acetylsalicylic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
74 50-78-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetylsalisylic acid
  • aspirin
  • acetylsalicylic acid
  • aspirin sodium
  • aspirin magnesium
  • aspirin potassium
  • aspirin calcium
  • aspirin anhydride
  • aspirin lysine
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
  • Molecular weight: 180.16
  • Formula: C9H8O4
  • CLOGP: 1.09
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -2.09
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 tablet O
30 mg O
3 g O
1 g P
3 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 4.60 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1.40 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 370.22 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.68 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.26 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 68 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -2.447 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.820 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.021 10^-6 cm/s High 1
herg hERG pIC50 4.213 pIC50 High 1
dh-clint Dog hepatocyte intrinsic clearance 7.031 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 63.580 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 59.660 % High 1
hh-clint Human hepatocyte intrinsic clearance 3.926 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 8.492 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 62.350 % High 1
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PAK4,PDK1,PDK2,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 65
kinase-selectivity-class ACVR2A,ACVR2B,AURKB,AXL,BRAF,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,JAK2,MAP2K3,MAP2K6,MAP3K14,MAPK1,MAPK7,MAPK8,MARK4,MTOR,PDK4,PIK3CD,PIK3CG,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK 33
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.525 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.439 High 1
mh-clint Mouse hepatocyte intrinsic clearance 135.831 High 1
mppb Mouse plasma protein binding (% unbound) 84.900 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.285 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 46.210 % High 1
rat-kpuu-brain Rat brain Kpuu 0.120 % High 1
rh-clint Rat hepatocyte intrinsic clearance 19.999 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 96.500 % High 1
rppb Rat plasma protein binding (% unbound) 46.150 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 790.679 uM High 1

Approvals:

DateAgencyCompanyOrphan
April 12, 1950 FDA ENDO PHARMS
Jan. 1, 1898 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2484.12 9.61 43 748690 326821 89552893
Myocardial infarction 2239.89 9.61 3507 745226 102465 89777249
Gastrointestinal haemorrhage 2228.70 9.61 3212 745521 87036 89792678
Hand deformity 2154.98 9.61 64 748669 296298 89583416
Systemic lupus erythematosus 2044.56 9.61 283 748450 361613 89518101
Glossodynia 2019.60 9.61 172 748561 321607 89558107
Anti-cyclic citrullinated peptide antibody positive 1813.19 9.61 27 748706 236406 89643308
Cerebrovascular accident 1791.33 9.61 3462 745271 120071 89759643
Synovitis 1666.01 9.61 347 748386 329405 89550309
Pericarditis 1549.77 9.61 201 748532 269950 89609764
Wound 1491.47 9.61 338 748395 302642 89577072
Duodenal ulcer perforation 1448.36 9.61 97 748636 221191 89658523
Folliculitis 1423.18 9.61 62 748671 204291 89675423
Helicobacter infection 1404.64 9.61 128 748605 226722 89652992
Infusion related reaction 1371.23 9.61 877 747856 415903 89463811
Cardiac failure congestive 1288.75 9.61 2648 746085 96046 89783668
Coronary artery disease 1286.48 9.61 1487 747246 32136 89847578
Acute myocardial infarction 1283.20 9.61 1512 747221 33378 89846336
Drug ineffective 1252.04 9.61 6550 742183 1377748 88501966
Treatment failure 1237.81 9.61 481 748252 303447 89576267
Muscle injury 1222.17 9.61 56 748677 176598 89703116
Alopecia 1126.59 9.61 1464 747269 493607 89386107
Arthropathy 1094.60 9.61 854 747879 365388 89514326
Swelling 1087.46 9.61 1115 747618 417943 89461771
Rheumatic fever 1074.24 9.61 44 748689 153077 89726637
Drug intolerance 1054.25 9.61 1289 747444 446302 89433412
Contraindicated product administered 1053.37 9.61 673 748060 319466 89560248
Irritable bowel syndrome 1037.56 9.61 223 748510 207225 89672489
Labelled drug-drug interaction medication error 1034.80 9.61 902 747831 13680 89866034
Discomfort 1017.40 9.61 497 748236 273838 89605876
Psoriatic arthropathy 1011.05 9.61 314 748419 228021 89651693
Hepatic enzyme increased 971.17 9.61 929 747804 359807 89519907
Sleep disorder due to general medical condition, insomnia type 968.48 9.61 19 748714 128675 89751039
Joint swelling 966.05 9.61 1673 747060 501627 89378087
Impaired healing 904.32 9.61 401 748332 233798 89645916
Fall 903.73 9.61 6939 741794 474871 89404843
Rheumatoid factor positive 892.78 9.61 168 748565 171482 89708232
Fibromyalgia 865.39 9.61 311 748422 205958 89673756
Therapeutic product effect decreased 839.50 9.61 639 748094 276932 89602782
Ill-defined disorder 831.55 9.61 247 748486 184644 89695070
Swollen joint count increased 793.52 9.61 28 748705 111178 89768536
Anaemia 772.63 9.61 5275 743458 347527 89532187
Lower respiratory tract infection 767.00 9.61 570 748163 250089 89629625
Type 2 diabetes mellitus 764.37 9.61 361 748372 202883 89676831
Blister 762.22 9.61 594 748139 254404 89625310
Angina pectoris 743.43 9.61 1235 747498 37925 89841789
Acute kidney injury 743.36 9.61 4860 743873 315527 89564187
Hypersensitivity 715.38 9.61 1695 747038 452982 89426732
Melaena 703.36 9.61 1129 747604 33668 89846046
Product use issue 697.19 9.61 1028 747705 328891 89550823
Abdominal discomfort 689.38 9.61 1859 746874 475469 89404245
Stomatitis 665.41 9.61 773 747960 273925 89605789
Syncope 663.01 9.61 2505 746228 130158 89749556
Facet joint syndrome 661.93 9.61 37 748696 98352 89781362
Transient ischaemic attack 641.14 9.61 1223 747510 41953 89837761
Liver injury 638.19 9.61 305 748428 170262 89709452
Atrial fibrillation 618.85 9.61 2463 746270 131148 89748566
Lip dry 616.53 9.61 60 748673 100895 89778819
C-reactive protein abnormal 595.64 9.61 158 748575 127271 89752443
Musculoskeletal stiffness 589.13 9.61 963 747770 295569 89584145
Joint range of motion decreased 588.72 9.61 193 748540 135450 89744264
Rhabdomyolysis 585.52 9.61 1303 747430 49953 89829761
Off label use 585.01 9.61 6059 742674 1096193 88783521
Breast cancer stage III 576.73 9.61 29 748704 84418 89795296
Plasma cell myeloma 571.46 9.61 1128 747605 39700 89840014
Upper gastrointestinal haemorrhage 545.23 9.61 803 747930 22173 89857541
Drug interaction 519.63 9.61 3986 744747 272467 89607247
Haemoglobin decreased 517.36 9.61 2675 746058 159281 89720433
Grip strength decreased 509.07 9.61 78 748655 92498 89787216
Blood cholesterol increased 505.05 9.61 584 748149 207428 89672286
Injury 502.29 9.61 533 748200 196816 89682898
Infection 495.15 9.61 1447 747286 360647 89519067
Cerebral haemorrhage 493.12 9.61 962 747771 33560 89846154
Aspirin-exacerbated respiratory disease 492.50 9.61 193 748540 497 89879217
Hypotension 472.58 9.61 4429 744304 320968 89558746
Deep vein thrombosis postoperative 451.63 9.61 35 748698 70774 89808940
Bursitis 450.34 9.61 264 748469 131390 89748324
Peripheral venous disease 440.81 9.61 80 748653 83841 89795873
Premature delivery 440.02 9.61 983 747750 37779 89841935
Angina unstable 439.97 9.61 408 748325 6735 89872979
Sleep disorder 422.96 9.61 612 748121 197418 89682296
Rheumatoid arthritis 420.53 9.61 1558 747175 361056 89518658
Intentional product use issue 419.83 9.61 716 748017 216176 89663538
Haematoma 418.54 9.61 968 747765 38080 89841634
Wound infection 409.18 9.61 183 748550 106219 89773495
Inflammation 396.28 9.61 537 748196 178055 89701659
Autoimmune disorder 384.51 9.61 82 748651 76662 89803052
Hyponatraemia 383.16 9.61 2142 746591 131396 89748318
Prescribed overdose 379.99 9.61 165 748568 97460 89782254
Condition aggravated 377.95 9.61 3127 745606 592418 89287296
Haematemesis 376.90 9.61 850 747883 32876 89846838
Epistaxis 369.22 9.61 1538 747195 83587 89796127
Haemorrhage 363.18 9.61 1330 747403 68039 89811675
Hypoglycaemia 360.49 9.61 1333 747400 68515 89811199
Mobility decreased 357.27 9.61 982 747751 249752 89629962
Dislocation of vertebra 353.21 9.61 29 748704 55939 89823775
Dehydration 353.10 9.61 2782 745951 191665 89688049
Adjustment disorder with depressed mood 351.09 9.61 32 748701 56721 89822993
Vascular stent thrombosis 349.34 9.61 175 748558 941 89878773
Haematochezia 341.73 9.61 1324 747409 69589 89810125
Gastrointestinal disorder 339.71 9.61 1041 747692 255646 89624068
Obesity 339.52 9.61 227 748506 105280 89774434
Rash 339.01 9.61 4589 744144 791511 89088203
Haemorrhage intracranial 334.22 9.61 512 748221 14650 89865064
Blepharospasm 333.17 9.61 35 748698 55410 89824304
Hypercholesterolaemia 332.91 9.61 211 748522 100681 89779033
Coronary artery occlusion 331.64 9.61 381 748352 8173 89871541
X-ray abnormal 329.11 9.61 10 748723 45414 89834300
Lower gastrointestinal haemorrhage 326.27 9.61 385 748348 8507 89871207
Pain 321.81 9.61 6050 742683 990291 88889423
Coronary arterial stent insertion 316.22 9.61 229 748504 2611 89877103
Bradycardia 314.96 9.61 1451 747282 82396 89797318
Arthralgia 314.56 9.61 4535 744198 773987 89105727
Constipation 309.64 9.61 3611 745122 276784 89602930
Completed suicide 299.27 9.61 459 748274 144599 89735115
Thrombosis 297.20 9.61 1297 747436 71954 89807760
Night sweats 286.80 9.61 386 748347 128380 89751334
Chest pain 286.43 9.61 3960 744773 315685 89564029
Lupus vulgaris 285.31 9.61 23 748710 45036 89834678
Angioedema 284.33 9.61 1176 747557 63700 89816014
Lower limb fracture 281.57 9.61 177 748556 84836 89794878
Urinary tract infection 279.79 9.61 3801 744932 301831 89577883
Pulmonary fibrosis 278.31 9.61 286 748447 107217 89772497
Myocardial ischaemia 276.11 9.61 446 748287 13368 89866346
Lung disorder 275.34 9.61 511 748222 149372 89730342
Cerebral infarction 274.84 9.61 650 748083 25946 89853768
Blood loss anaemia 273.89 9.61 377 748356 9763 89869951
Migraine 270.90 9.61 746 747987 189646 89690068
Gastric ulcer 268.79 9.61 657 748076 26791 89852923
Full blood count decreased 267.01 9.61 688 748045 29001 89850713
Nail disorder 265.25 9.61 79 748654 58988 89820726
Hyperkalaemia 264.10 9.61 1151 747582 63813 89815901
Hip arthroplasty 263.15 9.61 151 748582 76057 89803657
Sinusitis 259.62 9.61 1713 747020 341375 89538339
Coronary artery stenosis 257.35 9.61 265 748468 5001 89874713
Onychomadesis 254.59 9.61 38 748695 45960 89833754
Weight increased 251.94 9.61 2223 746510 415704 89464010
Renal failure 249.73 9.61 1896 746837 129111 89750603
Acute coronary syndrome 249.48 9.61 373 748360 10440 89869274
Hemiparesis 246.63 9.61 698 748035 31121 89848593
Coronary artery bypass 244.81 9.61 182 748551 2167 89877547
Product use in unapproved indication 242.86 9.61 1702 747031 334534 89545180
Subdural haematoma 241.54 9.61 467 748266 16178 89863536
Breast cancer stage II 238.52 9.61 13 748720 35321 89844393
C-reactive protein 238.50 9.61 4 748729 31363 89848351
Device expulsion 237.65 9.61 29 748704 40857 89838857
Lactic acidosis 237.28 9.61 935 747798 49528 89830186
Retinitis 234.39 9.61 23 748710 38435 89841279
Cardiac failure 232.40 9.61 1626 747107 107870 89771844
Gait inability 230.59 9.61 545 748188 145911 89733803
Mitral valve incompetence 230.06 9.61 548 748185 21976 89857738
Sciatica 214.71 9.61 315 748418 101067 89778647
Asthenia 214.25 9.61 5849 742884 527902 89351812
Blood glucose increased 213.17 9.61 1433 747300 93813 89785901
Pregnancy 212.72 9.61 124 748609 61923 89817791
Duodenal ulcer 212.57 9.61 324 748409 9228 89870486
Maternal exposure during pregnancy 211.77 9.61 1927 746806 358136 89521578
Road traffic accident 211.17 9.61 352 748381 107274 89772440
Knee arthroplasty 211.13 9.61 225 748508 82957 89796757
C-reactive protein increased 210.25 9.61 779 747954 180610 89699104
Chronic obstructive pulmonary disease 209.51 9.61 1181 747552 72648 89807066
Diarrhoea 208.86 9.61 9617 739116 929573 88950141
Osteoarthritis 206.90 9.61 872 747861 194858 89684856
Dizziness 205.93 9.61 6346 742387 582938 89296776
Ischaemic stroke 205.90 9.61 520 748213 21646 89858068
Injection site reaction 204.04 9.61 277 748456 91803 89787911
Therapeutic product effect incomplete 203.61 9.61 866 747867 193030 89686684
Hemiplegia 201.85 9.61 426 748307 15734 89863980
Product prescribing error 200.14 9.61 626 748107 29519 89850195
Dyspnoea 198.67 9.61 9034 739699 871921 89007793
Liver function test increased 195.47 9.61 248 748485 84607 89795107
Nasopharyngitis 194.26 9.61 2289 746444 404815 89474899
Adverse event 192.87 9.61 427 748306 116991 89762723
Dyspnoea exertional 189.92 9.61 1133 747600 71155 89808559
Therapy non-responder 189.70 9.61 542 748191 136162 89743552
Urticaria 188.98 9.61 1662 747071 311072 89568642
Myalgia 187.69 9.61 2243 746490 172882 89706832
Product administration error 185.94 9.61 560 748173 25863 89853851
Blood pressure increased 182.89 9.61 2459 746274 194758 89684956
Renal impairment 181.80 9.61 1491 747242 103930 89775784
Thrombosis in device 178.57 9.61 170 748563 2905 89876809
Subarachnoid haemorrhage 177.91 9.61 431 748302 17473 89862241
Sinus bradycardia 176.99 9.61 416 748317 16536 89863178
Carotid artery stenosis 176.22 9.61 219 748514 5115 89874599
Cataract 176.19 9.61 1109 747624 70983 89808731
Coeliac disease 175.80 9.61 74 748659 44536 89835178
Neuropathy peripheral 174.90 9.61 1816 746917 135154 89744560
Wheezing 173.84 9.61 1201 747532 236879 89642835
Product label confusion 173.37 9.61 3 748730 22847 89856867
Cardiac disorder 172.24 9.61 926 747807 55946 89823768
Palpitations 169.04 9.61 1801 746932 134927 89744787
Dry mouth 167.92 9.61 865 747868 183194 89696520
Diverticulum intestinal haemorrhagic 167.08 9.61 129 748604 1632 89878082
Dysarthria 162.91 9.61 884 747849 53598 89826116
Onychomycosis 162.42 9.61 53 748680 37323 89842391
Arteriosclerosis 161.78 9.61 308 748425 10545 89869169
Hepatic cirrhosis 161.75 9.61 170 748563 63083 89816631
Aphasia 160.81 9.61 741 747992 42071 89837643
Deafness transitory 160.51 9.61 134 748599 1909 89877805
Pyrexia 160.47 9.61 4192 744541 656293 89223421
Live birth 159.60 9.61 254 748479 78853 89800861
Balance disorder 159.39 9.61 1358 747375 95722 89783992
Arteriosclerosis coronary artery 156.27 9.61 283 748450 9320 89870394
Epilepsy 155.64 9.61 275 748458 81931 89797783
Blood creatine phosphokinase increased 154.80 9.61 624 748109 33399 89846315
Lupus-like syndrome 154.57 9.61 107 748626 48739 89830975
Pericardial haemorrhage 151.45 9.61 125 748608 1751 89877963
Coordination abnormal 149.70 9.61 452 748281 20904 89858810
Anti-cyclic citrullinated peptide antibody 149.47 9.61 23 748710 27198 89852516
Vascular stent stenosis 149.29 9.61 84 748649 592 89879122
Low birth weight baby 147.75 9.61 274 748459 9193 89870521
Orthostatic hypotension 146.20 9.61 709 748024 41118 89838596
Haematuria 145.81 9.61 624 748109 34313 89845401
Faeces discoloured 145.48 9.61 447 748286 20873 89858841
Myelosuppression 143.94 9.61 138 748595 53453 89826261
Presyncope 143.65 9.61 582 748151 31223 89848491
Oedema peripheral 142.88 9.61 2956 745777 254959 89624755
Vascular pseudoaneurysm 141.60 9.61 116 748617 1607 89878107
Blood creatinine increased 141.37 9.61 1369 747364 100017 89779697
Gastric ulcer haemorrhage 141.25 9.61 196 748537 5115 89874599
Rectal haemorrhage 140.89 9.61 1167 747566 81577 89798137
International normalised ratio increased 139.63 9.61 765 747968 46551 89833163
Febrile neutropenia 139.50 9.61 753 747980 157596 89722118
Back injury 138.63 9.61 109 748624 46513 89833201
Red blood cell sedimentation rate increased 136.75 9.61 299 748434 82296 89797418
Incorrect route of product administration 136.40 9.61 130 748603 50496 89829218
Laryngitis 134.79 9.61 132 748601 50621 89829093
Porphyria acute 133.81 9.61 3 748730 17972 89861742
Hypophagia 132.03 9.61 618 748115 35319 89844395
Taste disorder 131.50 9.61 190 748543 61356 89818358
Deep vein thrombosis 130.14 9.61 1242 747491 90378 89789336
Shock haemorrhagic 129.49 9.61 302 748431 11943 89867771
Gastritis erosive 128.12 9.61 213 748520 6542 89873172
Internal haemorrhage 127.29 9.61 203 748530 6017 89873697
Eating disorder 126.23 9.61 513 748220 27560 89852154
Retroperitoneal haemorrhage 125.88 9.61 141 748592 2939 89876775
Gastritis 125.86 9.61 679 748054 41074 89838640
Product monitoring error 125.83 9.61 171 748562 4373 89875341
Blood glucose decreased 125.79 9.61 453 748280 22976 89856738
Carotid artery thrombosis 125.75 9.61 250 748483 8842 89870872
Head injury 125.53 9.61 551 748182 30637 89849077
Loss of consciousness 124.41 9.61 1735 746998 138503 89741211
Product quality issue 124.17 9.61 296 748437 79029 89800685
Bone erosion 124.16 9.61 153 748580 52868 89826846
Hip fracture 123.86 9.61 572 748161 32505 89847209
Malignant neoplasm progression 123.77 9.61 459 748274 106411 89773303
Foot deformity 123.70 9.61 188 748545 59463 89820251
Prescribed underdose 123.03 9.61 273 748460 74746 89804968
Haemorrhagic stroke 122.09 9.61 204 748529 6292 89873422
Haemoptysis 121.68 9.61 572 748161 32748 89846966
Neurologic neglect syndrome 120.84 9.61 242 748491 8605 89871109
Liver disorder 118.60 9.61 556 748177 120713 89759001
Hypoaesthesia 118.56 9.61 1853 746880 312357 89567357
Duodenal ulcer haemorrhage 118.41 9.61 125 748608 2431 89877283
Chronic kidney disease 118.24 9.61 765 747968 49426 89830288
Finger deformity 118.18 9.61 62 748671 32835 89846879
Peripheral arterial occlusive disease 117.64 9.61 167 748566 4454 89875260
Lacunar infarction 116.97 9.61 142 748591 3235 89876479
Joint stiffness 116.84 9.61 298 748435 77744 89801970
Haemorrhagic transformation stroke 114.26 9.61 91 748642 1208 89878506
Retroperitoneal haematoma 114.03 9.61 140 748593 3228 89876486
Coronary artery thrombosis 113.49 9.61 86 748647 1056 89878658
Hyperlipidaemia 112.93 9.61 431 748302 22485 89857229
Maternal exposure timing unspecified 112.65 9.61 24 748709 22459 89857255
Cough 112.48 9.61 3911 744822 365051 89514663
Dysphagia 112.42 9.61 1420 747313 110858 89768856
Exostosis 111.59 9.61 166 748567 52968 89826746
Ecchymosis 111.24 9.61 286 748447 12037 89867677
Foetal growth restriction 109.95 9.61 241 748492 9139 89870575
Stent placement 108.64 9.61 153 748580 4050 89875664
Nasal oedema 108.37 9.61 195 748538 6389 89873325
Myopathy 107.16 9.61 299 748434 13219 89866495
Blood urea increased 106.63 9.61 516 748217 29897 89849817
White blood cell count decreased 106.62 9.61 1957 746776 165152 89714562
Adjustment disorder 105.48 9.61 241 748492 9401 89870313
Pulmonary oedema 104.84 9.61 874 747859 61206 89818508
Premature baby 104.72 9.61 448 748285 24629 89855085
General physical health deterioration 104.12 9.61 2189 746544 352926 89526788
Disability 103.62 9.61 110 748623 40635 89839079
Tricuspid valve incompetence 103.38 9.61 339 748394 16392 89863322
Blood potassium decreased 103.14 9.61 712 748021 47015 89832699
Atrioventricular block 101.65 9.61 225 748508 8590 89871124
Arrhythmia 100.82 9.61 647 748086 41685 89838029
Feeling abnormal 100.66 9.61 1941 746792 165294 89714420
Musculoskeletal pain 99.02 9.61 920 747813 170331 89709383
Blood pressure decreased 98.42 9.61 999 747734 73896 89805818
Immunodeficiency 97.86 9.61 128 748605 43106 89836608
Cognitive disorder 96.15 9.61 936 747797 68471 89811243
Cardiac arrest 95.40 9.61 1304 747429 103631 89776083
Pneumonia 95.30 9.61 6301 742432 631758 89247956
Post procedural haemorrhage 95.24 9.61 219 748514 8579 89871135
Cardiogenic shock 94.49 9.61 427 748306 24041 89855673
Platelet count decreased 92.66 9.61 1619 747114 135350 89744364
Arterial occlusive disease 92.54 9.61 269 748464 12177 89867537
Cardiovascular disorder 92.17 9.61 283 748450 13209 89866505
Drug tolerance decreased 91.94 9.61 78 748655 32052 89847662
Diverticulum 91.22 9.61 263 748470 11850 89867864
Disorientation 91.16 9.61 651 748082 43463 89836251
Gastrointestinal pain 89.95 9.61 249 748484 10957 89868757
Abdominal wall haematoma 89.59 9.61 124 748609 3228 89876486
Loss of personal independence in daily activities 89.04 9.61 708 748025 135397 89744317
Drug abuse 88.74 9.61 364 748369 81983 89797731
Personality disorder 87.80 9.61 264 748469 12180 89867534
Electrolyte imbalance 87.71 9.61 409 748324 23336 89856378
Flatulence 87.55 9.61 614 748119 40753 89838961
Oesophageal intramural haematoma 86.53 9.61 36 748697 114 89879600
Peripheral ischaemia 85.92 9.61 162 748571 5505 89874209
Intraventricular haemorrhage 85.82 9.61 104 748629 2365 89877349
Hyperglycaemia 85.76 9.61 717 748016 50253 89829461
Colitis microscopic 85.69 9.61 244 748489 10915 89868799
Ear pain 85.09 9.61 222 748511 57480 89822234
Ischaemic cardiomyopathy 84.27 9.61 106 748627 2507 89877207
Sinus node dysfunction 83.66 9.61 156 748577 5256 89874458
Ventricular fibrillation 83.60 9.61 281 748452 13763 89865951
Cerebral ischaemia 83.34 9.61 184 748549 7012 89872702
Cardiomegaly 82.85 9.61 343 748390 18582 89861132
Aortic valve stenosis 82.16 9.61 135 748598 4105 89875609
Systemic infection 81.91 9.61 144 748589 4631 89875083
Post procedural haematoma 81.86 9.61 77 748656 1295 89878419
Ageusia 81.40 9.61 305 748428 15771 89863943
Peripheral vascular disorder 80.86 9.61 170 748563 6261 89873453
Coronary artery restenosis 80.48 9.61 44 748689 291 89879423
Peripheral swelling 80.13 9.61 2702 746031 410404 89469310
Extradural haematoma 79.98 9.61 92 748641 1976 89877738
Vascular graft 79.87 9.61 62 748671 791 89878923
Gastric haemorrhage 79.32 9.61 179 748554 6924 89872790
Infusion site reaction 79.27 9.61 29 748704 19010 89860704
Swollen tongue 79.21 9.61 650 748083 45306 89834408
Iron deficiency anaemia 79.06 9.61 396 748337 23266 89856448
Ventricular tachycardia 78.71 9.61 408 748325 24300 89855414
Mental status changes 78.12 9.61 634 748099 44045 89835669
Walking aid user 77.45 9.61 108 748625 35398 89844316
Seronegative arthritis 77.24 9.61 27 748706 18207 89861507
Sensory loss 77.10 9.61 325 748408 17750 89861964
Cerebellar haemorrhage 76.86 9.61 81 748652 1572 89878142
Pulmonary hypertension 76.85 9.61 608 748125 41915 89837799
Electrocardiogram ST segment elevation 76.66 9.61 127 748606 3889 89875825
Tremor 76.56 9.61 1730 747003 151443 89728271
Vertigo 76.42 9.61 898 747835 68913 89810801
Pulmonary embolism 76.22 9.61 1511 747222 129309 89750405
Ventricular extrasystoles 76.14 9.61 262 748471 12988 89866726
Deafness 76.08 9.61 378 748355 22136 89857578
Subdural haemorrhage 76.01 9.61 116 748617 3307 89876407
Joint destruction 75.82 9.61 10 748723 13277 89866437
Atrioventricular block complete 75.80 9.61 215 748518 9596 89870118
Metabolic acidosis 75.73 9.61 748 747985 54928 89824786
Body height decreased 75.53 9.61 244 748489 11705 89868009
Cystitis 75.17 9.61 863 747870 65855 89813859
Circulatory collapse 74.38 9.61 404 748329 24500 89855214
Pallor 74.00 9.61 510 748223 33655 89846059
HELLP syndrome 73.96 9.61 69 748664 1148 89878566
Therapeutic response decreased 73.95 9.61 436 748297 89293 89790421
Haemorrhagic arteriovenous malformation 73.69 9.61 32 748701 116 89879598
Glycosylated haemoglobin increased 73.67 9.61 289 748444 15273 89864441
Abnormal loss of weight 72.94 9.61 169 748564 6654 89873060
Urinary incontinence 72.83 9.61 546 748187 37020 89842694
Gangrene 72.59 9.61 253 748480 12623 89867091
Vision blurred 72.56 9.61 1298 747435 108995 89770719
Pre-eclampsia 72.02 9.61 228 748505 10820 89868894
Drug tolerance 71.75 9.61 29 748704 17887 89861827
Haematocrit decreased 71.73 9.61 591 748142 41241 89838473
Chest discomfort 71.43 9.61 1570 747163 136795 89742919
Spinal epidural haematoma 70.43 9.61 70 748663 1264 89878450
Sopor 70.40 9.61 395 748338 24249 89855465
Skin discolouration 70.14 9.61 615 748118 43700 89836014
Coagulopathy 69.69 9.61 378 748355 22911 89856803
Skin haemorrhage 69.46 9.61 355 748378 21025 89858689
Lip swelling 68.11 9.61 549 748184 38061 89841653
Blood calcium decreased 68.03 9.61 455 748278 29727 89849987
Ischaemia 67.78 9.61 141 748592 5154 89874560
Hiatus hernia 67.56 9.61 399 748334 24962 89854752
Ventricular hypertrophy 67.11 9.61 109 748624 3282 89876432
Motor dysfunction 66.50 9.61 325 748408 18905 89860809
Joint dislocation 66.14 9.61 171 748562 44411 89835303
Creatinine renal clearance decreased 65.79 9.61 320 748413 18579 89861135
Intermittent claudication 65.34 9.61 78 748655 1745 89877969
Blood pressure inadequately controlled 65.26 9.61 153 748580 6071 89873643
Respiratory tract infection 64.69 9.61 760 747973 58318 89821396
Gastrointestinal vascular malformation haemorrhagic 63.79 9.61 33 748700 192 89879522
Hypokalaemia 63.68 9.61 1475 747258 129641 89750073
Diverticulum intestinal 63.61 9.61 193 748540 8949 89870765
Atrioventricular block second degree 63.48 9.61 124 748609 4328 89875386
Diabetes mellitus inadequate control 63.35 9.61 314 748419 18370 89861344
Sinus disorder 63.06 9.61 494 748239 33953 89845761
Heparin-induced thrombocytopenia 62.85 9.61 137 748596 5175 89874539
Visual acuity reduced 62.81 9.61 369 748364 23041 89856673
Lethargy 62.53 9.61 797 747936 62342 89817372
Multiple injuries 62.30 9.61 77 748656 1788 89877926
Hypochromic anaemia 62.10 9.61 83 748650 2088 89877626
Food allergy 61.26 9.61 72 748661 25406 89854308
Bundle branch block left 61.12 9.61 173 748560 7712 89872002
Retinal haemorrhage 60.77 9.61 142 748591 5622 89874092
Cardiac tamponade 60.75 9.61 140 748593 5492 89874222
Left ventricular hypertrophy 60.08 9.61 147 748586 5997 89873717
Hyperhidrosis 60.04 9.61 1513 747220 134792 89744922
Aneurysm 59.74 9.61 107 748626 3493 89876221
Labile blood pressure 59.26 9.61 76 748657 1834 89877880
Nausea 59.01 9.61 10226 738507 1100090 88779624
Hypertensive crisis 58.97 9.61 297 748436 17487 89862227
Hypovolaemia 58.96 9.61 231 748502 12200 89867514
Dementia 58.86 9.61 368 748365 23493 89856221
Hypoacusis 58.71 9.61 413 748320 27437 89852277
Arterial haemorrhage 58.16 9.61 87 748646 2436 89877278
Overlap syndrome 58.15 9.61 3 748730 8545 89871169
Aortic valve incompetence 58.01 9.61 152 748581 6472 89873242
Back pain 57.88 9.61 3189 745544 313986 89565728
Spinal cord haemorrhage 57.35 9.61 33 748700 244 89879470
Affect lability 57.34 9.61 298 748435 17765 89861949
Acute respiratory failure 57.11 9.61 574 748159 42344 89837370
Nervousness 56.72 9.61 478 748255 33578 89846136
Angiopathy 56.69 9.61 134 748599 5346 89874368
Pharyngitis 56.36 9.61 342 748391 21605 89858109
Carotid arteriosclerosis 56.30 9.61 60 748673 1180 89878534
Small intestinal haemorrhage 56.24 9.61 81 748652 2190 89877524
Occult blood positive 56.09 9.61 111 748622 3912 89875802
Anuria 56.03 9.61 257 748476 14561 89865153
Pulmonary alveolar haemorrhage 56.01 9.61 141 748592 5857 89873857
Swollen joint count 55.96 9.61 4 748729 8649 89871065
Renal artery stenosis 55.90 9.61 79 748654 2098 89877616
Eructation 55.55 9.61 207 748526 10675 89869039
Large intestine polyp 55.16 9.61 187 748546 9199 89870515
Haemorrhage subcutaneous 55.16 9.61 100 748633 3296 89876418
Colitis ischaemic 55.02 9.61 225 748508 12121 89867593
Shoulder arthroplasty 54.57 9.61 112 748621 4054 89875660
Cardiac failure chronic 54.06 9.61 134 748599 5512 89874202
Coronary artery dissection 53.99 9.61 52 748681 902 89878812
Weight decreased 53.96 9.61 3737 744996 376173 89503541
Diverticulitis 53.85 9.61 591 748142 44596 89835118
Sinus arrest 53.81 9.61 77 748656 2069 89877645
Infective pulmonary exacerbation of cystic fibrosis 53.53 9.61 10 748723 10269 89869445
Rash vesicular 53.52 9.61 43 748690 18154 89861560
Troponin increased 52.96 9.61 234 748499 13047 89866667
Feeding disorder 52.92 9.61 285 748448 17227 89862487
Cerebrovascular disorder 52.57 9.61 88 748645 2718 89876996
Hallucination 52.52 9.61 801 747932 65158 89814556
Diastolic dysfunction 52.14 9.61 156 748577 7177 89872537
Eye disorder 51.91 9.61 396 748337 26994 89852720
Potentiating drug interaction 51.72 9.61 132 748601 5530 89874184
Pharyngeal haemorrhage 51.48 9.61 43 748690 613 89879101
Therapy partial responder 51.19 9.61 64 748669 21979 89857735
Muscle haemorrhage 51.16 9.61 96 748637 3250 89876464
Arterial stenosis 50.89 9.61 45 748688 696 89879018
Cardiac valve disease 50.86 9.61 116 748617 4519 89875195
Aortic aneurysm 50.82 9.61 112 748621 4263 89875451
Cytokine release syndrome 50.78 9.61 96 748637 27877 89851837
Respiratory disorder 50.76 9.61 320 748413 64496 89815218
Large intestinal haemorrhage 50.55 9.61 64 748669 1524 89878190
Tooth disorder 50.53 9.61 434 748299 30656 89849058
Urogenital haemorrhage 50.51 9.61 30 748703 237 89879477
Cardiac operation 50.36 9.61 105 748628 3844 89875870
Suicidal ideation 50.25 9.61 380 748353 73475 89806239
Diabetes mellitus 50.19 9.61 784 747949 64091 89815623
Drug ineffective for unapproved indication 50.17 9.61 333 748400 66311 89813403
Temperature regulation disorder 50.16 9.61 29 748704 14550 89865164
Ankylosing spondylitis 49.83 9.61 23 748710 13110 89866604
Blood potassium increased 49.32 9.61 317 748416 20432 89859282
Embolic stroke 49.30 9.61 106 748627 3966 89875748
Microcytic anaemia 49.26 9.61 102 748631 3716 89875998
Aortic stenosis 49.10 9.61 139 748594 6197 89873517
Carotid artery occlusion 49.02 9.61 139 748594 6203 89873511
Hypersensitivity myocarditis 48.60 9.61 30 748703 256 89879458
Exercise tolerance decreased 48.46 9.61 155 748578 7396 89872318
Injection site pain 48.44 9.61 1079 747654 172620 89707094
Tachyarrhythmia 48.32 9.61 125 748608 5281 89874433
Electric shock 47.98 9.61 65 748668 1657 89878057
Respiratory failure 47.96 9.61 1300 747433 117118 89762596
Unresponsive to stimuli 47.94 9.61 504 748229 37617 89842097
Non-cardiac chest pain 47.81 9.61 143 748590 6578 89873136
Traumatic haemorrhage 46.58 9.61 39 748694 558 89879156
Duodenitis 46.56 9.61 108 748625 4255 89875459
Tinnitus 46.53 9.61 553 748180 42549 89837165
Blood alkaline phosphatase increased 46.38 9.61 604 748129 47475 89832239
Speech disorder 46.24 9.61 578 748155 45007 89834707
Femoral neck fracture 46.00 9.61 187 748546 10046 89869668
Mucosal inflammation 45.90 9.61 283 748450 57342 89822372
Seasonal allergy 45.66 9.61 336 748397 22647 89857067
Adverse reaction 45.60 9.61 112 748621 29600 89850114
Cerebral haematoma 45.59 9.61 106 748627 4183 89875531
Hepatic cytolysis 45.54 9.61 119 748614 30797 89848917
Essential hypertension 45.53 9.61 135 748598 6180 89873534
Immune-mediated myositis 45.46 9.61 76 748657 2345 89877369
Hypomagnesaemia 45.46 9.61 472 748261 35116 89844598
Haemorrhoidal haemorrhage 45.45 9.61 121 748612 5202 89874512
Osteoporosis 45.44 9.61 544 748189 95987 89783727
Supraventricular extrasystoles 45.39 9.61 120 748613 5137 89874577
Peripheral artery stenosis 45.29 9.61 39 748694 581 89879133
Dilatation atrial 45.22 9.61 68 748665 1913 89877801
Intestinal haemorrhage 45.20 9.61 108 748625 4339 89875375
Labile hypertension 45.13 9.61 36 748697 479 89879235
Breast cancer stage I 44.82 9.61 12 748721 9612 89870102
Blood pressure abnormal 44.79 9.61 297 748436 19348 89860366
Petechiae 44.77 9.61 252 748481 15489 89864225
Catheterisation cardiac 44.71 9.61 115 748618 4841 89874873
Hepatotoxicity 44.32 9.61 211 748522 45631 89834083
Functional gastrointestinal disorder 44.17 9.61 116 748617 4946 89874768
Blood sodium decreased 44.11 9.61 384 748349 27229 89852485
Gout 44.11 9.61 264 748469 16595 89863119
Peripheral coldness 43.97 9.61 229 748504 13663 89866051
Ischaemic cerebral infarction 43.73 9.61 58 748675 1448 89878266
Mitral valve stenosis 43.62 9.61 55 748678 1304 89878410
Disease progression 43.34 9.61 974 747759 155641 89724073
Aortic arteriosclerosis 43.33 9.61 151 748582 7533 89872181
Exposure to toxic agent 43.14 9.61 7 748726 7960 89871754
Hypervolaemia 43.05 9.61 437 748296 32320 89847394
Dyspepsia 42.97 9.61 1277 747456 196883 89682831
Intracranial aneurysm 42.76 9.61 105 748628 4293 89875421
Platelet count increased 42.62 9.61 307 748426 20552 89859162
Extremity contracture 42.57 9.61 53 748680 1240 89878474
Atrial flutter 42.48 9.61 189 748544 10569 89869145
Atrioventricular block first degree 41.87 9.61 160 748573 8351 89871363
Increased tendency to bruise 41.87 9.61 202 748531 11688 89868026
Polyarthritis 41.86 9.61 54 748679 18296 89861418
Orthopnoea 41.79 9.61 138 748595 6697 89873017
Haematotoxicity 41.63 9.61 26 748707 12509 89867205
Drug dependence 41.60 9.61 115 748618 29212 89850502
Cardiac failure acute 41.53 9.61 202 748531 11727 89867987
Foetal exposure during pregnancy 41.51 9.61 540 748193 42435 89837279
Urosepsis 41.38 9.61 309 748424 20923 89858791
Poisoning deliberate 41.37 9.61 45 748688 16441 89863273
Inappropriate antidiuretic hormone secretion 40.97 9.61 289 748444 19216 89860498
Oesophagitis haemorrhagic 40.89 9.61 33 748700 447 89879267
Vomiting 40.85 9.61 7252 741481 781041 89098673
Burning sensation 40.75 9.61 744 747989 62708 89817006
Chromaturia 40.72 9.61 285 748448 18902 89860812
Renal haemorrhage 40.69 9.61 48 748685 1060 89878654
Subcutaneous haematoma 40.67 9.61 63 748670 1820 89877894
Renal cyst 40.66 9.61 213 748520 12737 89866977
Injection site swelling 40.65 9.61 308 748425 59531 89820183
Febrile bone marrow aplasia 40.26 9.61 15 748718 9723 89869991
Haemophagocytic lymphohistiocytosis 40.14 9.61 41 748692 15418 89864296
Bezoar 40.02 9.61 77 748656 2657 89877057
Accidental exposure to product 39.80 9.61 197 748536 42169 89837545
Heart rate irregular 39.56 9.61 339 748394 23929 89855785
Myoglobin blood increased 39.38 9.61 56 748677 1496 89878218
Heart rate decreased 39.28 9.61 641 748092 52864 89826850
Pulmonary renal syndrome 39.13 9.61 35 748698 550 89879164
Dysgeusia 39.08 9.61 631 748102 51929 89827785
Pericardial effusion 39.07 9.61 471 748262 36362 89843352
Haemodialysis 38.65 9.61 159 748574 8588 89871126
Unintended pregnancy 38.57 9.61 8 748725 7629 89872085
Depressed level of consciousness 38.55 9.61 829 747904 71955 89807759
Coronary artery aneurysm 38.31 9.61 13 748720 18 89879696
Graft versus host disease 38.22 9.61 10 748723 8134 89871580
Diabetic retinopathy 38.22 9.61 75 748658 2627 89877087
Subchorionic haematoma 38.16 9.61 20 748713 120 89879594
Low density lipoprotein increased 38.15 9.61 150 748583 7935 89871779
Neuroleptic malignant syndrome 38.11 9.61 41 748692 15055 89864659
Carotid artery disease 38.00 9.61 57 748676 1600 89878114
Haemothorax 37.75 9.61 70 748663 2348 89877366
Drug use disorder 37.74 9.61 11 748722 8332 89871382
Multiple-drug resistance 37.56 9.61 9 748724 7767 89871947
Skin exfoliation 37.42 9.61 778 747955 67135 89812579
Haemarthrosis 37.41 9.61 94 748639 3900 89875814
Brain stem haemorrhage 37.36 9.61 40 748693 791 89878923
Left ventricular failure 37.21 9.61 131 748602 6569 89873145
General symptom 36.85 9.61 40 748693 14628 89865086
Gastrointestinal toxicity 36.83 9.61 16 748717 9451 89870263
Glomerular filtration rate decreased 36.81 9.61 253 748480 16679 89863035
Hypocholesterolaemia 36.45 9.61 5 748728 6444 89873270
Epstein-Barr virus infection 36.42 9.61 20 748713 10324 89869390
Aortic valve replacement 36.33 9.61 42 748691 907 89878807
Pollakiuria 36.31 9.61 425 748308 32580 89847134
Neoplasm progression 36.20 9.61 217 748516 44269 89835445
Neurotoxicity 36.12 9.61 77 748656 21390 89858324
Mucosal erosion 36.10 9.61 59 748674 1786 89877928
Diabetic neuropathy 36.09 9.61 101 748632 4473 89875241
Schizophrenia 36.02 9.61 42 748691 14872 89864842
Diverticulitis intestinal haemorrhagic 35.99 9.61 19 748714 116 89879598
Bundle branch block right 35.97 9.61 113 748620 5340 89874374
Spontaneous haematoma 35.80 9.61 46 748687 1112 89878602
Retinal artery occlusion 35.78 9.61 66 748667 2205 89877509
Eye swelling 35.78 9.61 386 748347 29000 89850714
Injection site erythema 35.72 9.61 585 748148 97917 89781797
Bradyarrhythmia 35.65 9.61 69 748664 2392 89877322
Brain herniation 35.38 9.61 95 748638 4105 89875609
Diabetic ketoacidosis 35.20 9.61 332 748401 24075 89855639
Thalamus haemorrhage 35.19 9.61 37 748696 716 89878998
Laboratory test abnormal 35.16 9.61 513 748220 41341 89838373
Red blood cell count decreased 35.04 9.61 558 748175 45793 89833921
Rhinorrhoea 35.03 9.61 967 747766 87349 89792365
Skin laceration 34.54 9.61 348 748385 25687 89854027
Tachypnoea 34.38 9.61 297 748436 21012 89858702
Sleep disorder due to a general medical condition 33.95 9.61 223 748510 44515 89835199
Liver function test abnormal 33.65 9.61 599 748134 50246 89829468
Coronary angioplasty 33.51 9.61 16 748717 76 89879638
Electrocardiogram ST segment depression 33.34 9.61 80 748653 3223 89876491
Linear IgA disease 33.24 9.61 64 748669 2210 89877504
Facial paralysis 33.12 9.61 231 748502 15303 89864411
Faecaloma 33.05 9.61 172 748561 10259 89869455
Eye haemorrhage 33.05 9.61 169 748564 10011 89869703
Normochromic normocytic anaemia 32.99 9.61 105 748628 4997 89874717
No adverse event 32.81 9.61 381 748352 67601 89812113
Angioplasty 32.72 9.61 50 748683 1427 89878287
Splenic rupture 32.64 9.61 48 748685 1323 89878391
Transplant dysfunction 32.61 9.61 3 748730 5279 89874435
Renal disorder 32.59 9.61 466 748267 37393 89842321
Metastases to liver 32.51 9.61 125 748608 28682 89851032
Oesophageal haemorrhage 32.50 9.61 31 748702 531 89879183
Pharyngeal oedema 32.49 9.61 210 748523 13561 89866153
Acute pulmonary oedema 32.48 9.61 161 748572 9419 89870295
Acidosis 32.41 9.61 198 748535 12538 89867176
Delirium 32.40 9.61 637 748096 103722 89775992
Uterine perforation 32.32 9.61 11 748722 7543 89872171
Hospitalisation 32.30 9.61 808 747925 127292 89752422
Subacute cutaneous lupus erythematosus 32.19 9.61 83 748650 3499 89876215
Hepatic ischaemia 32.19 9.61 36 748697 749 89878965
Peptic ulcer 32.11 9.61 109 748624 5366 89874348
Peripheral artery thrombosis 32.06 9.61 62 748671 2148 89877566
Metastases to central nervous system 32.02 9.61 60 748673 17482 89862232
Haemoperitoneum 31.97 9.61 82 748651 3446 89876268
Dysuria 31.95 9.61 480 748253 38921 89840793
Metastases to bone 31.89 9.61 106 748627 25399 89854315
Gastrointestinal ulcer haemorrhage 31.77 9.61 39 748694 899 89878815
Memory impairment 31.74 9.61 1319 747414 195925 89683789
Oesophageal mucosal dissection 31.70 9.61 10 748723 9 89879705
Full blood count increased 31.62 9.61 45 748688 1203 89878511
Thrombocytosis 31.52 9.61 128 748605 6873 89872841
Infarction 31.52 9.61 74 748659 2939 89876775
Pruritus 31.50 9.61 3955 744778 537570 89342144
Small intestinal ulcer haemorrhage 31.39 9.61 14 748719 55 89879659
Nasal disorder 31.38 9.61 78 748655 3214 89876500
Unevaluable event 31.09 9.61 631 748102 54217 89825497
Prothrombin time prolonged 30.87 9.61 161 748572 9611 89870103
Jaundice 30.74 9.61 407 748326 32110 89847604
Electrocardiogram abnormal 30.71 9.61 167 748566 10131 89869583
Dry gangrene 30.69 9.61 32 748701 613 89879101
Colitis ulcerative 30.56 9.61 334 748399 59932 89819782
Adverse drug reaction 30.54 9.61 732 748001 115969 89763745
Platelet dysfunction 30.53 9.61 16 748717 96 89879618
Unintentional medical device removal 30.49 9.61 10 748723 7020 89872694
Cerebral thrombosis 30.44 9.61 54 748679 1749 89877965
Lupus vasculitis 30.44 9.61 31 748702 577 89879137
Multiple allergies 30.41 9.61 222 748511 14924 89864790
Mouth haemorrhage 30.35 9.61 145 748588 8356 89871358
Thrombotic thrombocytopenic purpura 30.34 9.61 89 748644 4049 89875665
Drug-induced liver injury 30.29 9.61 544 748189 89774 89789940
Giant cell arteritis 30.18 9.61 73 748660 2956 89876758
Hypomania 30.18 9.61 18 748715 8879 89870835
Arteriospasm coronary 30.02 9.61 101 748632 4949 89874765
Acute myeloid leukaemia 29.98 9.61 80 748653 20560 89859154
Sneezing 29.98 9.61 378 748355 29491 89850223
Pleural effusion 29.89 9.61 1170 747563 110821 89768893
Brain contusion 29.88 9.61 32 748701 633 89879081
Ulcer haemorrhage 29.84 9.61 114 748619 26207 89853507
Hypovolaemic shock 29.82 9.61 127 748606 6967 89872747
Vascular dementia 29.82 9.61 30 748703 550 89879164
Facial paresis 29.80 9.61 86 748647 3877 89875837
Cholecystitis acute 29.75 9.61 155 748578 9249 89870465
Cardiac pacemaker insertion 29.69 9.61 92 748641 4315 89875399
Underdose 29.59 9.61 294 748439 53723 89825991
Blood triglycerides increased 29.55 9.61 205 748528 13556 89866158
Percutaneous coronary intervention 29.47 9.61 21 748712 233 89879481
Blood pressure systolic increased 29.45 9.61 660 748073 57685 89822029
Humerus fracture 29.40 9.61 159 748574 9626 89870088
Sedation complication 29.38 9.61 240 748493 16704 89863010
Gastrointestinal ulcer 29.36 9.61 69 748664 2742 89876972
Hypokinesia 29.22 9.61 226 748507 15471 89864243
Acute graft versus host disease 29.17 9.61 5 748728 5463 89874251
Blood creatine phosphokinase MB increased 29.14 9.61 43 748690 1189 89878525
Brain stem infarction 29.06 9.61 36 748697 838 89878876
Exposure during pregnancy 28.97 9.61 1642 747091 236768 89642946
Renal function test abnormal 28.90 9.61 127 748606 7064 89872650
Hypertensive heart disease 28.89 9.61 66 748667 2574 89877140
Cardiomyopathy 28.72 9.61 274 748459 19932 89859782
Hepatic cyst 28.72 9.61 119 748614 6449 89873265
Electrocardiogram ST-T change 28.70 9.61 38 748695 947 89878767
Mitral valve calcification 28.61 9.61 42 748691 1156 89878558
Extremity necrosis 28.51 9.61 55 748678 1902 89877812
Throat clearing 28.46 9.61 83 748650 3764 89875950
Cytomegalovirus infection 28.40 9.61 118 748615 26484 89853230
Pulmonary toxicity 28.36 9.61 32 748701 11499 89868215
Hypertensive emergency 28.33 9.61 59 748674 2158 89877556
Vascular graft occlusion 28.13 9.61 19 748714 192 89879522
Mallory-Weiss syndrome 28.07 9.61 50 748683 1625 89878089
Cerebral artery occlusion 28.04 9.61 39 748694 1020 89878694
Rectal polyp 28.00 9.61 40 748693 1073 89878641
Premature labour 27.98 9.61 198 748535 13178 89866536
Gingival bleeding 27.98 9.61 215 748518 14688 89865026
Gastritis haemorrhagic 27.97 9.61 52 748681 1748 89877966
Product dose omission issue 27.90 9.61 2785 745948 288902 89590812
Electrocardiogram T wave inversion 27.76 9.61 80 748653 3603 89876111
Eye injury 27.74 9.61 30 748703 10990 89868724
Aortic occlusion 27.73 9.61 16 748717 119 89879595
Cellulitis 27.71 9.61 968 747765 90369 89789345
International normalised ratio decreased 27.66 9.61 94 748639 4630 89875084
Nodal rhythm 27.60 9.61 52 748681 1766 89877948
Supraventricular tachycardia 27.58 9.61 230 748503 16106 89863608
Gestational hypertension 27.57 9.61 71 748662 2991 89876723
Adenovirus infection 27.55 9.61 3 748730 4619 89875095
Anti-neutrophil cytoplasmic antibody positive vasculitis 27.50 9.61 84 748649 3909 89875805
Sinus congestion 27.50 9.61 347 748386 27077 89852637
Traumatic intracranial haemorrhage 27.46 9.61 31 748702 652 89879062
Peripheral artery occlusion 27.45 9.61 47 748686 1479 89878235
Ocular retrobulbar haemorrhage 27.34 9.61 15 748718 100 89879614
Periorbital oedema 27.27 9.61 120 748613 6679 89873035
Bleeding time prolonged 27.25 9.61 30 748703 613 89879101
Blindness transient 27.13 9.61 91 748642 4452 89875262
Puncture site haemorrhage 26.99 9.61 24 748709 374 89879340
Device difficult to use 26.94 9.61 66 748667 17459 89862255
Swelling face 26.92 9.61 871 747862 80481 89799233
Abortion early 26.90 9.61 10 748723 21 89879693
Aortic valve sclerosis 26.86 9.61 41 748692 1169 89878545
Hyperprolactinaemia 26.81 9.61 6 748727 5427 89874287
Limb injury 26.79 9.61 387 748346 31121 89848593
Therapeutic drug monitoring analysis not performed 26.68 9.61 43 748690 1286 89878428
Injection site pruritus 26.65 9.61 300 748433 53534 89826180
Femoral artery aneurysm 26.63 9.61 7 748726 0 89879714
Monoclonal immunoglobulin present 26.53 9.61 56 748677 2068 89877646
Oral herpes 26.51 9.61 165 748568 33359 89846355
Rheumatoid nodule 26.48 9.61 82 748651 20084 89859630
Hyperventilation 26.42 9.61 118 748615 6610 89873104
Gastrointestinal angiodysplasia 26.40 9.61 29 748704 591 89879123
Basal ganglia haemorrhage 26.36 9.61 32 748701 729 89878985
Human chorionic gonadotropin increased 26.30 9.61 53 748680 1893 89877821
Groin pain 26.26 9.61 182 748551 12031 89867683
Cytomegalovirus viraemia 26.23 9.61 15 748718 7571 89872143
Abdominal pain lower 26.19 9.61 372 748361 29805 89849909
Cerebral microinfarction 26.01 9.61 8 748725 6 89879708
Electrocardiogram T wave abnormal 25.95 9.61 64 748669 2624 89877090
Respiratory tract congestion 25.88 9.61 343 748390 27067 89852647
Vitreous haemorrhage 25.86 9.61 63 748670 2563 89877151
Cerebral artery stenosis 25.79 9.61 28 748705 563 89879151
Spinal subdural haematoma 25.78 9.61 16 748717 138 89879576
Sudden cardiac death 25.77 9.61 57 748676 2175 89877539
Thrombotic stroke 25.66 9.61 27 748706 523 89879191
Procedural haemorrhage 25.65 9.61 70 748663 3054 89876660
Complication of device insertion 25.62 9.61 29 748704 10407 89869307
Tuberculosis 25.58 9.61 40 748693 12509 89867205
Pneumocystis jirovecii pneumonia 25.57 9.61 92 748641 21524 89858190
Paresis 25.55 9.61 64 748669 2650 89877064
Capillary fragility test 25.45 9.61 10 748723 26 89879688
Anal haemorrhage 25.33 9.61 61 748672 2463 89877251
Ventricular dysfunction 25.24 9.61 78 748655 3653 89876061
Dizziness postural 25.13 9.61 144 748589 8909 89870805
Metastases to lymph nodes 25.05 9.61 36 748697 11653 89868061
Menstruation irregular 25.04 9.61 18 748715 8042 89871672
Asthma-chronic obstructive pulmonary disease overlap syndrome 25.02 9.61 5 748728 4894 89874820
Cardiac murmur 25.01 9.61 245 748488 17949 89861765
Aortic valve disease 24.94 9.61 42 748691 1304 89878410
Hernia 24.90 9.61 202 748531 14029 89865685
Hypocalvaria 24.90 9.61 11 748722 42 89879672
Device dislocation 24.87 9.61 155 748578 31327 89848387
Conjunctival haemorrhage 24.86 9.61 81 748652 3903 89875811
Brain natriuretic peptide increased 24.86 9.61 107 748626 5898 89873816
Retinal vein occlusion 24.83 9.61 61 748672 2495 89877219
Treatment noncompliance 24.82 9.61 581 748152 51146 89828568
Sarcoidosis 24.77 9.61 31 748702 10642 89869072
Dermatitis exfoliative 24.75 9.61 101 748632 5435 89874279
Cold sweat 24.71 9.61 200 748533 13881 89865833
Mediastinal haematoma 24.67 9.61 13 748720 79 89879635
Endocarditis enterococcal 24.63 9.61 19 748714 240 89879474
Dystonia 24.57 9.61 65 748668 16754 89862960
Carotid bruit 24.56 9.61 30 748703 688 89879026
Blood glucose fluctuation 24.55 9.61 95 748638 4988 89874726
Orbital haematoma 24.50 9.61 9 748724 18 89879696
Placental insufficiency 24.31 9.61 47 748686 1628 89878086
Disturbance in social behaviour 24.26 9.61 3 748730 4185 89875529
Amenorrhoea 24.24 9.61 37 748696 11685 89868029
Respiratory alkalosis 24.18 9.61 73 748660 3375 89876339
Adenocarcinoma of colon 24.18 9.61 64 748669 2742 89876972
Influenza 24.15 9.61 1394 747339 137870 89741844
Left atrial dilatation 24.13 9.61 51 748682 1885 89877829
Vitamin B12 deficiency 24.11 9.61 124 748609 7362 89872352
Pulmonary arterial hypertension 24.02 9.61 326 748407 25861 89853853
Product blister packaging issue 23.95 9.61 21 748712 321 89879393
Joint effusion 23.91 9.61 83 748650 19627 89860087
Arterial intramural haematoma 23.83 9.61 16 748717 160 89879554
Oesophageal ulcer haemorrhage 23.77 9.61 24 748709 442 89879272
Dyslipidaemia 23.77 9.61 154 748579 9953 89869761
Ejection fraction decreased 23.75 9.61 326 748407 25927 89853787
Respiratory depression 23.67 9.61 59 748674 15516 89864198
Restrictive pulmonary disease 23.62 9.61 57 748676 2305 89877409
Dissociation 23.62 9.61 13 748720 6702 89873012
Hypothermia 23.54 9.61 214 748519 15361 89864353
Nail ridging 23.53 9.61 25 748708 490 89879224
Cholelithiasis 23.46 9.61 584 748149 51922 89827792
Placental infarction 23.44 9.61 20 748713 294 89879420
Hypercoagulation 23.38 9.61 55 748678 2187 89877527
Hepatorenal syndrome 23.30 9.61 52 748681 1996 89877718
Periorbital haematoma 23.19 9.61 31 748702 780 89878934
Urinary bladder haemorrhage 23.17 9.61 39 748694 1210 89878504
Akinesia 23.13 9.61 47 748686 1689 89878025
Cerebellar infarction 23.12 9.61 55 748678 2203 89877511
Spinal fracture 23.12 9.61 281 748452 21735 89857979
Haemorrhoids 23.11 9.61 329 748404 26373 89853341
Oesophagitis 23.09 9.61 231 748502 17018 89862696
Occult blood 23.09 9.61 40 748693 1271 89878443
Euglycaemic diabetic ketoacidosis 23.04 9.61 107 748626 6094 89873620
Coronary artery dilatation 23.01 9.61 9 748724 23 89879691
Diarrhoea haemorrhagic 22.99 9.61 159 748574 10504 89869210
Premature rupture of membranes 22.98 9.61 99 748634 5459 89874255
Pulmonary thrombosis 22.97 9.61 149 748584 9633 89870081
Diverticular perforation 22.92 9.61 76 748657 3696 89876018
Intentional self-injury 22.88 9.61 145 748588 29189 89850525
Transfusion 22.84 9.61 233 748500 17255 89862459
Reye's syndrome 22.83 9.61 6 748727 0 89879714
Extrasystoles 22.80 9.61 100 748633 5557 89874157
Intra-abdominal haematoma 22.80 9.61 53 748680 2091 89877623
Insomnia 22.78 9.61 2409 746324 331065 89548649
Deformity 22.77 9.61 41 748692 12129 89867585
Respiratory rate increased 22.75 9.61 217 748516 15784 89863930
Congenital anomaly 22.74 9.61 12 748721 6335 89873379
Postoperative wound infection 22.65 9.61 189 748544 13237 89866477
Urine odour abnormal 22.64 9.61 119 748614 7125 89872589
Wound infection pseudomonas 22.61 9.61 51 748682 1972 89877742
Oral allergy syndrome 22.61 9.61 13 748720 96 89879618
Pustular psoriasis 22.60 9.61 78 748655 18478 89861236
Heart valve incompetence 22.48 9.61 70 748663 3292 89876422
Vascular stent occlusion 22.44 9.61 11 748722 56 89879658
Haemorrhagic erosive gastritis 22.40 9.61 24 748709 475 89879239
Intracardiac thrombus 22.37 9.61 56 748677 2318 89877396
Neck pain 22.37 9.61 744 747989 113219 89766495
Device inappropriate shock delivery 22.35 9.61 7 748726 6 89879708
Platelet aggregation increased 22.35 9.61 7 748726 6 89879708
Shock 22.34 9.61 348 748385 28430 89851284
Haemorrhagic cerebral infarction 22.28 9.61 27 748706 614 89879100
Orthostatic intolerance 22.16 9.61 40 748693 1314 89878400
Cerebral atrophy 22.15 9.61 99 748634 5547 89874167
Large intestinal ulcer 22.11 9.61 77 748656 3840 89875874
Androgenetic alopecia 22.05 9.61 16 748717 183 89879531
Aortic aneurysm rupture 21.99 9.61 25 748708 530 89879184
Depression 21.97 9.61 2161 746572 298440 89581274
Agitation 21.84 9.61 717 748016 66381 89813333
Pancreatitis acute 21.84 9.61 380 748353 31735 89847979
Ventricular internal diameter abnormal 21.75 9.61 9 748724 28 89879686
Heart rate increased 21.72 9.61 1141 747592 111761 89767953
Spinal compression fracture 21.66 9.61 206 748527 14972 89864742
Fear of injection 21.64 9.61 23 748710 8492 89871222
Hypoglycaemic coma 21.63 9.61 64 748669 2926 89876788
Wound haematoma 21.54 9.61 11 748722 62 89879652
Nonreassuring foetal heart rate pattern 21.54 9.61 11 748722 62 89879652
Neovascular age-related macular degeneration 21.54 9.61 22 748711 411 89879303
Device issue 21.52 9.61 149 748584 29388 89850326
Premature separation of placenta 21.51 9.61 55 748678 2307 89877407
Electrocardiogram PR prolongation 21.50 9.61 31 748702 839 89878875
Influenza like illness 21.47 9.61 842 747891 79769 89799945
Placenta accreta 21.45 9.61 17 748716 224 89879490
High density lipoprotein decreased 21.37 9.61 59 748674 2592 89877122
Frequent bowel movements 21.35 9.61 336 748397 56599 89823115
Essential thrombocythaemia 21.28 9.61 16 748717 194 89879520
Prinzmetal angina 21.24 9.61 34 748699 1011 89878703
Mitral valve prolapse 21.22 9.61 58 748675 2533 89877181
Upper limb fracture 21.20 9.61 272 748461 21306 89858408
Intracranial haematoma 21.14 9.61 21 748712 379 89879335
Therapeutic response shortened 21.14 9.61 107 748626 22772 89856942
Truncus arteriosus persistent 21.09 9.61 21 748712 380 89879334
Pregnancy with implant contraceptive 21.06 9.61 3 748730 3758 89875956
Cardiac flutter 21.04 9.61 85 748648 4553 89875161
Alanine aminotransferase increased 21.00 9.61 1187 747546 117151 89762563
Pelvic haematoma 20.96 9.61 28 748705 704 89879010
Nasal obstruction 20.93 9.61 58 748675 2554 89877160
Foetal exposure timing unspecified 20.87 9.61 22 748711 427 89879287
Muscle spasms 20.86 9.61 2382 746351 249501 89630213
Intervertebral discitis 20.64 9.61 83 748650 4437 89875277
Vascular occlusion 20.60 9.61 36 748697 1152 89878562
Artery dissection 20.58 9.61 13 748720 116 89879598
Complications of intestinal transplant 20.58 9.61 8 748725 20 89879694
Lactose intolerance 20.58 9.61 68 748665 3301 89876413
Ocular icterus 20.56 9.61 76 748657 3904 89875810
Choroidal haemorrhage 20.54 9.61 10 748723 50 89879664
Face injury 20.53 9.61 75 748658 3830 89875884
Feeling cold 20.52 9.61 330 748403 27135 89852579
Infected skin ulcer 20.51 9.61 58 748675 2584 89877130
Aortic thrombosis 20.51 9.61 38 748695 1274 89878440
Platelet aggregation inhibition 20.50 9.61 15 748718 174 89879540
Light chain analysis increased 20.47 9.61 42 748691 1520 89878194
Stress cardiomyopathy 20.44 9.61 184 748549 13171 89866543
Hyper IgE syndrome 20.44 9.61 23 748710 482 89879232
Wound haemorrhage 20.39 9.61 61 748672 2806 89876908
Anal abscess 20.15 9.61 11 748722 5697 89874017
Blood sodium increased 20.13 9.61 65 748668 3117 89876597
Activated partial thromboplastin time prolonged 20.13 9.61 122 748611 7703 89872011
Infantile haemangioma 20.08 9.61 12 748721 96 89879618
Muscle strain 20.04 9.61 143 748590 9544 89870170
Postpartum haemorrhage 19.92 9.61 54 748679 2347 89877367
Ultrasound Doppler abnormal 19.90 9.61 14 748719 152 89879562
Compartment syndrome 19.81 9.61 61 748672 2851 89876863
Gravitational oedema 19.72 9.61 36 748697 1193 89878521
Urinary retention 19.69 9.61 429 748304 37315 89842399
Congenital acrochordon 19.68 9.61 9 748724 38 89879676
Necrotising myositis 19.65 9.61 29 748704 802 89878912
Photopsia 19.64 9.61 88 748645 4936 89874778
Plasma cell myeloma recurrent 19.59 9.61 78 748655 4150 89875564
Dementia Alzheimer's type 19.57 9.61 32 748701 969 89878745
Skin wrinkling 19.54 9.61 39 748694 1383 89878331
Rectourethral fistula 19.54 9.61 8 748725 24 89879690
Congenital ureterocele 19.54 9.61 8 748725 24 89879690
Intentional product misuse 19.52 9.61 577 748156 89027 89790687
Hypertensive nephropathy 19.51 9.61 26 748707 652 89879062
Blindness unilateral 19.51 9.61 120 748613 7616 89872098
Coronary artery insufficiency 19.50 9.61 11 748722 78 89879636
Plasmacytoma 19.47 9.61 59 748674 2734 89876980
Cardiac septal defect 19.44 9.61 28 748705 757 89878957
Arteriovenous malformation 19.43 9.61 41 748692 1514 89878200
Upper respiratory tract infection 19.40 9.61 864 747869 127454 89752260
Cerebrovascular insufficiency 19.38 9.61 11 748722 79 89879635
Troponin T increased 19.36 9.61 42 748691 1581 89878133
Psoriasis 19.36 9.61 1010 747723 146744 89732970
Polycythaemia vera 19.35 9.61 15 748718 191 89879523
Hepatic infarction 19.28 9.61 26 748707 660 89879054
Uveitis 19.27 9.61 67 748666 15836 89863878
Nodule 19.26 9.61 135 748598 26551 89853163
Bronchitis 19.24 9.61 1490 747243 151437 89728277
Post-traumatic stress disorder 19.21 9.61 109 748624 6719 89872995
Long QT syndrome 19.13 9.61 75 748658 3962 89875752
Femoral hernia incarcerated 19.12 9.61 40 748693 1468 89878246
Chronic gastrointestinal bleeding 19.11 9.61 13 748720 133 89879581
Otitis media staphylococcal 19.02 9.61 5 748728 0 89879714
Otitis media bacterial 19.02 9.61 5 748728 0 89879714
Lip haematoma 19.02 9.61 5 748728 0 89879714
Myocardial rupture 18.95 9.61 10 748723 61 89879653
Paraesthesia 18.93 9.61 1795 746938 248531 89631183
Emotional distress 18.90 9.61 416 748317 36246 89843468
Coronary artery reocclusion 18.85 9.61 8 748725 27 89879687
Cardiac aneurysm 18.85 9.61 32 748701 1000 89878714
Leg amputation 18.83 9.61 52 748681 2285 89877429
Lymphatic fistula 18.81 9.61 39 748694 1422 89878292
Full blood count abnormal 18.79 9.61 415 748318 36182 89843532
Cerebral microhaemorrhage 18.77 9.61 16 748717 235 89879479
Antiphospholipid syndrome 18.72 9.61 51 748682 2223 89877491
Hot flush 18.68 9.61 633 748100 58855 89820859
Lacunar stroke 18.66 9.61 16 748717 237 89879477
Arterial injury 18.64 9.61 19 748714 354 89879360
Lung neoplasm malignant 18.64 9.61 293 748440 23980 89855734
Blood immunoglobulin A increased 18.62 9.61 36 748697 1247 89878467
Stroke in evolution 18.61 9.61 11 748722 86 89879628
Gastrointestinal tract mucosal pigmentation 18.61 9.61 26 748707 683 89879031
Caesarean section 18.60 9.61 235 748498 18342 89861372
Diplopia 18.55 9.61 337 748396 28377 89851337
Gastroenteritis 18.51 9.61 342 748391 28887 89850827
Cardiac stress test abnormal 18.50 9.61 24 748709 586 89879128
Blood uric acid increased 18.49 9.61 118 748615 7586 89872128
Hyperkeratosis 18.45 9.61 109 748624 6819 89872895
Disturbance in attention 18.45 9.61 515 748218 46594 89833120
Atrial tachycardia 18.45 9.61 98 748635 5892 89873822
Infective exacerbation of chronic obstructive airways disease 18.36 9.61 39 748694 1447 89878267
Bone pain 18.33 9.61 655 748078 61328 89818386
Haemorrhage urinary tract 18.28 9.61 33 748700 1084 89878630
Interventricular septum rupture 18.25 9.61 6 748727 7 89879707
Lumbar spinal stenosis 18.23 9.61 93 748640 5504 89874210
Cerebral mass effect 18.09 9.61 32 748701 1034 89878680
Helicobacter gastritis 18.05 9.61 42 748691 1658 89878056
Arterial stent insertion 18.02 9.61 8 748725 31 89879683
Anticoagulation drug level below therapeutic 18.00 9.61 26 748707 705 89879009
Spontaneous haemorrhage 17.94 9.61 26 748707 707 89879007
Muscle necrosis 17.90 9.61 28 748705 816 89878898
Cerebral hyperperfusion syndrome 17.87 9.61 7 748726 18 89879696
Sinus arrhythmia 17.87 9.61 38 748695 1411 89878303
Somnolence 17.82 9.61 1981 746752 207103 89672611
Haematoma muscle 17.81 9.61 44 748689 1806 89877908
Paradoxical drug reaction 17.76 9.61 13 748720 5753 89873961
Compression fracture 17.75 9.61 129 748604 8660 89871054
Chronic left ventricular failure 17.65 9.61 24 748709 614 89879100
Pelvic fracture 17.65 9.61 198 748535 15021 89864693
Respiratory distress 17.64 9.61 434 748299 38512 89841202
Cerebrovascular stenosis 17.64 9.61 8 748725 33 89879681
Nephrogenic systemic fibrosis 17.62 9.61 74 748659 4034 89875680
Inappropriate schedule of product administration 17.60 9.61 1036 747697 148897 89730817
Ventricular hypokinesia 17.57 9.61 89 748644 5252 89874462
Postmenopausal haemorrhage 17.57 9.61 52 748681 2378 89877336
Drop attacks 17.55 9.61 25 748708 669 89879045
Renal pain 17.50 9.61 117 748616 7642 89872072
Diabetic nephropathy 17.50 9.61 42 748691 1692 89878022
Dermatitis allergic 17.27 9.61 219 748514 17108 89862606
Aneurysm ruptured 17.25 9.61 24 748709 628 89879086
Multiple drug therapy 17.23 9.61 108 748625 6901 89872813
Blindness 17.22 9.61 312 748421 26256 89853458
Platelet function test abnormal 17.15 9.61 10 748723 76 89879638
Vaginal haemorrhage 17.14 9.61 358 748375 30913 89848801
Oliguria 17.10 9.61 148 748585 10476 89869238
Myocardial necrosis marker increased 17.09 9.61 48 748685 2130 89877584
Erosive oesophagitis 17.05 9.61 43 748690 1788 89877926
Nodal arrhythmia 17.03 9.61 35 748698 1268 89878446
Multiple sclerosis 17.03 9.61 324 748409 27516 89852198
Brown-Sequard syndrome 17.02 9.61 6 748727 10 89879704
Capillary fragility increased 17.02 9.61 6 748727 10 89879704
Macular oedema 17.00 9.61 83 748650 4826 89874888
Spondylitis 17.00 9.61 60 748673 14118 89865596
Thyroid disorder 16.97 9.61 223 748510 17562 89862152
Altered state of consciousness 16.97 9.61 360 748373 31172 89848542
Urinary straining 16.92 9.61 8 748725 37 89879677
Vitello-intestinal duct remnant 16.92 9.61 8 748725 37 89879677
Tongue haemorrhage 16.91 9.61 21 748712 490 89879224
Contrast media reaction 16.82 9.61 34 748699 1217 89878497
Paronychia 16.82 9.61 25 748708 7981 89871733
Subclavian artery stenosis 16.81 9.61 15 748718 235 89879479
Suicide attempt 16.80 9.61 484 748249 74915 89804799
Bladder disorder 16.79 9.61 149 748584 10623 89869091
Drug-disease interaction 16.75 9.61 29 748704 921 89878793
Peritonitis 16.74 9.61 242 748491 19463 89860251
Visual field defect 16.74 9.61 109 748624 7057 89872657
Meniscus injury 16.69 9.61 121 748612 8116 89871598
Sprue-like enteropathy 16.68 9.61 29 748704 924 89878790
Cerebral artery embolism 16.67 9.61 30 748703 983 89878731
Schizoaffective disorder 16.65 9.61 11 748722 5136 89874578
Myocarditis 16.64 9.61 181 748552 13625 89866089
Tongue oedema 16.64 9.61 89 748644 5365 89874349
Ductus arteriosus premature closure 16.63 9.61 19 748714 405 89879309
Platelet disorder 16.60 9.61 50 748683 2309 89877405
Intestinal ischaemia 16.59 9.61 128 748605 8755 89870959
Hypocapnia 16.59 9.61 21 748712 500 89879214
Injection site scab 16.58 9.61 24 748709 652 89879062
Aortic dilatation 16.57 9.61 31 748702 1047 89878667
Cardiac valve replacement complication 16.56 9.61 12 748721 137 89879577
Traumatic haematoma 16.55 9.61 42 748691 1753 89877961
Heart transplant rejection 16.53 9.61 27 748706 817 89878897
Tenosynovitis stenosans 16.49 9.61 6 748727 3947 89875767
Aspergillus infection 16.45 9.61 41 748692 10782 89868932
Coronary artery surgery 16.43 9.61 8 748725 40 89879674
Ventricle rupture 16.43 9.61 8 748725 40 89879674
Depressed mood 16.43 9.61 537 748196 49685 89830029
Erosive duodenitis 16.43 9.61 21 748712 505 89879209
Stenosis 16.42 9.61 46 748687 2038 89877676
Palmar-plantar erythrodysaesthesia syndrome 16.42 9.61 150 748583 27873 89851841
Pathogen resistance 16.42 9.61 26 748707 8089 89871625
Cystic fibrosis 16.41 9.61 6 748727 3935 89875779
Contrast encephalopathy 16.36 9.61 13 748720 172 89879542
Umbilical haemorrhage 16.33 9.61 6 748727 12 89879702
Angiogram 16.33 9.61 10 748723 84 89879630
Rib fracture 16.29 9.61 308 748425 26127 89853587
Iliac artery occlusion 16.25 9.61 15 748718 246 89879468
Inguinal hernia 16.23 9.61 46 748687 2052 89877662
Tubulointerstitial nephritis 16.21 9.61 297 748436 25046 89854668
Rotator cuff syndrome 16.21 9.61 202 748531 15717 89863997
Venous occlusion 16.20 9.61 28 748705 888 89878826
Dysaesthesia 16.20 9.61 86 748647 5169 89874545
Skin cancer 16.19 9.61 177 748556 13342 89866372
Restlessness 16.16 9.61 398 748335 35322 89844392
Drug resistance 16.15 9.61 167 748566 30282 89849432
Leukocytosis 16.09 9.61 352 748381 30638 89849076
Arthritis 16.09 9.61 1177 747556 166138 89713576
Hypochloraemia 16.08 9.61 53 748680 2569 89877145
Blood prolactin increased 16.08 9.61 5 748728 3632 89876082
Deafness unilateral 16.07 9.61 63 748670 3328 89876386
Body temperature increased 16.05 9.61 266 748467 44444 89835270
Otolithiasis 16.02 9.61 6 748727 13 89879701
Acute left ventricular failure 15.99 9.61 34 748699 1262 89878452
Metabolic encephalopathy 15.95 9.61 103 748630 6649 89873065
Oesophageal ulcer 15.94 9.61 84 748649 5035 89874679
Hallucination, gustatory 15.93 9.61 9 748724 64 89879650
Coagulation time abnormal 15.93 9.61 9 748724 64 89879650
Diabetic foot 15.92 9.61 39 748694 1592 89878122
PCO2 decreased 15.92 9.61 34 748699 1266 89878448
Blood magnesium decreased 15.92 9.61 199 748534 15494 89864220
Cardiorenal syndrome 15.89 9.61 31 748702 1081 89878633
Defaecation urgency 15.85 9.61 97 748636 6145 89873569
Subretinal fluid 15.83 9.61 24 748709 680 89879034
Hypotensive transfusion reaction 15.82 9.61 8 748725 44 89879670
Presbyacusis 15.76 9.61 3 748730 3039 89876675
Hypoosmolar state 15.70 9.61 14 748719 219 89879495
Macular degeneration 15.70 9.61 418 748315 37552 89842162
Catheter site haemorrhage 15.68 9.61 66 748667 3602 89876112
Post cholecystectomy syndrome 15.67 9.61 27 748706 854 89878860
Mucormycosis 15.61 9.61 6 748727 3815 89875899
Lung infiltration 15.59 9.61 194 748539 15088 89864626
Tongue haematoma 15.59 9.61 11 748722 120 89879594
Amyloid related imaging abnormality-oedema/effusion 15.59 9.61 28 748705 916 89878798
Cerebral amyloid angiopathy 15.55 9.61 14 748719 222 89879492
Arthrodesis 15.54 9.61 3 748730 3009 89876705
Campylobacter gastroenteritis 15.53 9.61 26 748707 803 89878911
Dysstasia 15.48 9.61 292 748441 24760 89854954
Pulmonary congestion 15.47 9.61 236 748497 19197 89860517
Pigmentation disorder 15.46 9.61 93 748640 5856 89873858
Dilatation ventricular 15.46 9.61 49 748684 2327 89877387
Squamous cell carcinoma of skin 15.43 9.61 110 748623 7339 89872375
Spinal osteoarthritis 15.42 9.61 233 748500 18915 89860799
Central nervous system inflammation 15.41 9.61 13 748720 188 89879526
Ear haemorrhage 15.41 9.61 38 748695 1558 89878156
Pancreatitis necrotising 15.39 9.61 49 748684 2332 89877382
Asphyxia 15.36 9.61 106 748627 6997 89872717
Immune effector cell-associated neurotoxicity syndrome 15.32 9.61 15 748718 5753 89873961
Tongue discomfort 15.30 9.61 54 748679 2711 89877003
Post transplant lymphoproliferative disorder 15.29 9.61 21 748712 6928 89872786
Nephrogenic anaemia 15.26 9.61 50 748683 2416 89877298
Left-to-right cardiac shunt 15.26 9.61 15 748718 267 89879447
Anaesthesia 15.25 9.61 19 748714 445 89879269
Metastases to lung 15.22 9.61 74 748659 15917 89863797
Embolism 15.22 9.61 132 748601 9349 89870365
Radical hysterectomy 15.22 9.61 4 748729 0 89879714
Emergency care examination abnormal 15.22 9.61 4 748729 0 89879714
Blood zinc decreased 15.22 9.61 4 748729 0 89879714
Cardiac procedure complication 15.21 9.61 12 748721 157 89879557
Mitral valve replacement 15.21 9.61 20 748713 495 89879219
Gallbladder disorder 15.19 9.61 239 748494 19564 89860150
Arteriovenous fistula occlusion 15.19 9.61 17 748716 354 89879360
Vascular resistance pulmonary decreased 15.16 9.61 9 748724 71 89879643
Blood glucose abnormal 15.16 9.61 132 748601 9360 89870354
Vertebral artery stenosis 15.14 9.61 10 748723 97 89879617
Lateral medullary syndrome 15.13 9.61 5 748728 6 89879708
Aplasia 15.12 9.61 7 748726 3984 89875730
Haemorrhagic infarction 15.12 9.61 16 748717 312 89879402
Subcapsular renal haematoma 15.11 9.61 17 748716 356 89879358
Galactorrhoea 15.09 9.61 10 748723 4662 89875052
Diabetic retinal oedema 15.03 9.61 18 748715 404 89879310
Juvenile idiopathic arthritis 15.03 9.61 7 748726 3970 89875744
Hepatitis B reactivation 15.01 9.61 7 748726 3967 89875747
Chronic gastritis 14.98 9.61 66 748667 3675 89876039
Blood calcium increased 14.96 9.61 159 748574 11899 89867815
Muscle relaxant therapy 14.96 9.61 12 748721 161 89879553
Graft thrombosis 14.95 9.61 14 748719 234 89879480
Thrombotic microangiopathy 14.90 9.61 73 748660 15670 89864044
Eye excision 14.87 9.61 7 748726 32 89879682
Venous stenosis 14.79 9.61 11 748722 131 89879583
Arteriovenous fistula 14.78 9.61 17 748716 365 89879349
Change of bowel habit 14.78 9.61 47 748686 2236 89877478
Haptoglobin increased 14.76 9.61 9 748724 75 89879639
Sleep apnoea syndrome 14.75 9.61 355 748378 31392 89848322
Device use error 14.74 9.61 23 748710 7198 89872516
QRS axis abnormal 14.73 9.61 32 748701 1206 89878508
Subclavian steal syndrome 14.70 9.61 7 748726 33 89879681
Subcapsular hepatic haematoma 14.70 9.61 5 748728 7 89879707
Postoperative thoracic procedure complication 14.70 9.61 5 748728 7 89879707
Electrocardiogram QT prolonged 14.70 9.61 736 747997 71720 89807994
Adenocarcinoma pancreas 14.68 9.61 31 748702 1145 89878569
Forced vital capacity decreased 14.65 9.61 31 748702 1147 89878567
Rash papulosquamous 14.65 9.61 10 748723 103 89879611
Glaucoma 14.62 9.61 247 748486 20508 89859206
Chronic fatigue syndrome 14.62 9.61 37 748696 1542 89878172
Craniocerebral injury 14.61 9.61 60 748673 3238 89876476
Accelerated hypertension 14.61 9.61 19 748714 465 89879249
Heart disease congenital 14.60 9.61 38 748695 1611 89878103
Monocytosis 14.56 9.61 28 748705 966 89878748
Catheter site haematoma 14.55 9.61 13 748720 204 89879510
Blue toe syndrome 14.55 9.61 19 748714 467 89879247
Putamen haemorrhage 14.55 9.61 13 748720 204 89879510
Alanine aminotransferase abnormal 14.54 9.61 14 748719 5412 89874302
Enlarged uvula 14.50 9.61 13 748720 205 89879509
Abortion incomplete 14.46 9.61 4 748729 3136 89876578
Acne 14.45 9.61 158 748575 28349 89851365
Left ventricular dysfunction 14.45 9.61 185 748548 14484 89865230
Retinal vascular occlusion 14.40 9.61 18 748715 423 89879291
Post procedural stroke 14.38 9.61 8 748725 55 89879659
Faeces hard 14.38 9.61 59 748674 3183 89876531
Laryngotracheal oedema 14.38 9.61 7 748726 35 89879679
Adrenal insufficiency 14.32 9.61 168 748565 29753 89849961
Malignant melanoma 14.31 9.61 163 748570 12413 89867301
Product used for unknown indication 14.30 9.61 24 748709 743 89878971
Blood iron decreased 14.26 9.61 218 748515 17741 89861973
Musculoskeletal disorder 14.24 9.61 256 748477 21513 89858201
Type V hyperlipidaemia 14.23 9.61 26 748707 862 89878852
Hypertensive angiopathy 14.19 9.61 9 748724 81 89879633
Congenital cardiovascular anomaly 14.18 9.61 19 748714 479 89879235
Urine output decreased 14.18 9.61 163 748570 12440 89867274
Vertigo positional 14.16 9.61 60 748673 3284 89876430
Autoimmune myositis 14.15 9.61 16 748717 337 89879377
Pulseless electrical activity 14.15 9.61 124 748609 8808 89870906
Azotaemia 14.15 9.61 84 748649 5264 89874450
Nephroangiosclerosis 14.14 9.61 13 748720 212 89879502
Musculoskeletal discomfort 14.14 9.61 248 748485 20743 89858971
Face oedema 14.13 9.61 271 748462 23047 89856667
Arterial disorder 14.13 9.61 34 748699 1372 89878342
Jejunal ulcer 14.10 9.61 10 748723 110 89879604
Embolic cerebral infarction 14.09 9.61 21 748712 586 89879128
Jaundice hepatocellular 14.07 9.61 7 748726 37 89879677
Anal incontinence 14.06 9.61 200 748533 16030 89863684
Vascular device infection 14.05 9.61 51 748682 11901 89867813
Contusion 14.05 9.61 1839 746894 249377 89630337
Ligament pain 14.05 9.61 13 748720 214 89879500
Electrocardiogram Q wave abnormal 14.03 9.61 12 748721 177 89879537
Glomerular filtration rate abnormal 14.03 9.61 33 748700 1312 89878402
Muscle atrophy 14.03 9.61 118 748615 8283 89871431
Therapy interrupted 14.03 9.61 311 748422 49797 89829917
Anion gap increased 14.03 9.61 46 748687 2224 89877490
Vasodilatation 14.01 9.61 54 748679 2830 89876884
Asthma 13.99 9.61 1769 746964 240391 89639323
Iliac vein occlusion 13.98 9.61 6 748727 21 89879693
Lacrimal haemorrhage 13.98 9.61 6 748727 21 89879693
Device breakage 13.95 9.61 64 748669 13980 89865734
Vascular wall hypertrophy 13.95 9.61 5 748728 9 89879705
Lymphoproliferative disorder 13.93 9.61 9 748724 4253 89875461
Cardiac perforation 13.92 9.61 8 748725 59 89879655
Stent malfunction 13.92 9.61 9 748724 84 89879630
Gastroduodenal haemorrhage 13.92 9.61 9 748724 84 89879630
Myopathy toxic 13.91 9.61 21 748712 593 89879121
Fracture 13.88 9.61 258 748475 21818 89857896
Glomerular filtration rate increased 13.88 9.61 43 748690 2017 89877697
Oesophageal adenocarcinoma 13.87 9.61 12 748721 180 89879534
Drug dose omission by device 13.86 9.61 41 748692 10190 89869524
Vasculitis 13.85 9.61 264 748469 22429 89857285
Eyelid oedema 13.81 9.61 151 748582 11383 89868331
Histrionic personality disorder 13.77 9.61 7 748726 39 89879675
Microalbuminuria 13.77 9.61 20 748713 545 89879169
Cervicobrachial syndrome 13.73 9.61 30 748703 1135 89878579
Hypergammaglobulinaemia 13.73 9.61 21 748712 600 89879114
Pancreatic steatosis 13.69 9.61 37 748696 1605 89878109
Dry skin 13.66 9.61 873 747860 87200 89792514
Lymphocytosis 13.66 9.61 55 748678 2942 89876772
Peripartum haemorrhage 13.61 9.61 5 748728 10 89879704
Arterial restenosis 13.61 9.61 5 748728 10 89879704
Hepatitis 13.60 9.61 463 748270 70276 89809438
Silent myocardial infarction 13.58 9.61 16 748717 353 89879361
Anaemia macrocytic 13.54 9.61 74 748659 4498 89875216
Fluid intake reduced 13.53 9.61 69 748664 4083 89875631
Obstructive shock 13.49 9.61 8 748725 63 89879651
Lipoprotein (a) increased 13.49 9.61 8 748725 63 89879651
Loose tooth 13.48 9.61 64 748669 3679 89876035
Incontinence 13.47 9.61 170 748563 13265 89866449
Left ventricular end-diastolic pressure increased 13.45 9.61 17 748716 404 89879310
Vessel puncture site haematoma 13.39 9.61 11 748722 153 89879561
Troponin I increased 13.37 9.61 49 748684 2506 89877208
Arterial repair 13.36 9.61 7 748726 42 89879672
Muscular weakness 13.35 9.61 1925 746808 204741 89674973
Hypocalcaemia 13.34 9.61 451 748282 41917 89837797
Headache 13.34 9.61 6698 742035 856048 89023666
Polymyositis 13.33 9.61 44 748689 2135 89877579
Kidney duplex 13.32 9.61 10 748723 121 89879593
Bradyphrenia 13.29 9.61 108 748625 7504 89872210
Cardiolipin antibody positive 13.27 9.61 11 748722 155 89879559
Hypoglycaemic unconsciousness 13.26 9.61 24 748709 790 89878924
N-terminal prohormone brain natriuretic peptide increased 13.21 9.61 54 748679 2908 89876806
Implantable defibrillator insertion 13.21 9.61 20 748713 566 89879148
Aortic dissection 13.20 9.61 47 748686 2370 89877344
Post procedural complication 13.19 9.61 226 748507 18816 89860898
Hand-eye coordination impaired 13.18 9.61 6 748727 25 89879689
Emphysema 13.14 9.61 156 748577 11999 89867715
Blood cholesterol abnormal 13.14 9.61 53 748680 2837 89876877
Vitamin B12 increased 13.13 9.61 39 748694 1787 89877927
Brain compression 13.13 9.61 19 748714 516 89879198
Pleurothotonus 13.12 9.61 32 748701 1303 89878411
Abdominal pain upper 13.09 9.61 2485 746248 330189 89549525
Claudication of jaw muscles 13.08 9.61 8 748725 67 89879647
Vitamin D decreased 13.06 9.61 154 748579 11825 89867889
Exposure via ingestion 13.05 9.61 3 748730 2664 89877050
Haemorrhagic disorder 13.01 9.61 27 748706 985 89878729
Aneurysm recanalisation 13.00 9.61 4 748729 3 89879711
Cardiac perfusion defect 13.00 9.61 6 748727 26 89879688
Congenital hydronephrosis 12.98 9.61 17 748716 419 89879295
Colon cancer 12.97 9.61 143 748590 10801 89868913
Infective aneurysm 12.92 9.61 17 748716 421 89879293
Localised infection 12.89 9.61 366 748367 33196 89846518
Amaurosis fugax 12.89 9.61 21 748712 634 89879080
Nail discolouration 12.83 9.61 57 748676 3185 89876529
Periorbital haemorrhage 12.82 9.61 11 748722 163 89879551
Clostridium difficile colitis 12.82 9.61 300 748433 26406 89853308
Device deployment issue 12.77 9.61 13 748720 4896 89874818
Polyuria 12.75 9.61 133 748600 9907 89869807
Bladder neoplasm surgery 12.73 9.61 5 748728 13 89879701
Mass 12.72 9.61 190 748543 15387 89864327
Spinal epidural haemorrhage 12.68 9.61 14 748719 287 89879427
Catatonia 12.64 9.61 19 748714 6037 89873677
Skin ulcer 12.63 9.61 520 748213 49555 89830159
Congenital multiplex arthrogryposis 12.61 9.61 8 748725 72 89879642
Collagen disorder 12.60 9.61 13 748720 246 89879468
Cystitis noninfective 12.59 9.61 32 748701 1337 89878377
Traumatic liver injury 12.57 9.61 14 748719 290 89879424
End stage renal disease 12.57 9.61 117 748616 8454 89871260
Sepsis syndrome 12.56 9.61 26 748707 947 89878767
Oesophageal disorder 12.53 9.61 50 748683 2663 89877051
Urine albumin/creatinine ratio increased 12.52 9.61 19 748714 539 89879175
Basal ganglia infarction 12.52 9.61 18 748715 486 89879228
Overweight 12.51 9.61 88 748645 5846 89873868
Catheterisation cardiac abnormal 12.49 9.61 14 748719 292 89879422
Blood pressure diastolic decreased 12.47 9.61 300 748433 26526 89853188
Graft haemorrhage 12.46 9.61 5 748728 14 89879700
Haemoglobin increased 12.45 9.61 105 748628 7376 89872338
Wrong product administered 12.45 9.61 107 748626 7558 89872156
Blood blister 12.45 9.61 44 748689 2211 89877503
Twin pregnancy 12.43 9.61 30 748703 1213 89878501
Iliac artery stenosis 12.43 9.61 8 748725 74 89879640
Nasal congestion 12.42 9.61 824 747909 82590 89797124
Rash macular 12.42 9.61 333 748400 29947 89849767
Diabetic metabolic decompensation 12.40 9.61 40 748693 1917 89877797
Vitamin D deficiency 12.40 9.61 209 748524 17347 89862367
Retinal vascular disorder 12.39 9.61 13 748720 251 89879463
Urinary tract stoma complication 12.36 9.61 7 748726 50 89879664
Barotrauma 12.34 9.61 11 748722 172 89879542
Aquagenic pruritus 12.32 9.61 6 748727 30 89879684
Stevens-Johnson syndrome 12.32 9.61 324 748409 29052 89850662
Thalamic infarction 12.30 9.61 18 748715 494 89879220
Drug dispensed to wrong patient 12.28 9.61 15 748718 344 89879370
Renal tubular dysfunction 12.27 9.61 18 748715 495 89879219
Seroma 12.27 9.61 54 748679 3006 89876708
Angiocardiogram 12.25 9.61 7 748726 51 89879663
Intra-abdominal haemorrhage 12.25 9.61 49 748684 2613 89877101
Hypereosinophilic syndrome 12.25 9.61 15 748718 345 89879369
Injection site rash 12.24 9.61 134 748599 24039 89855675
Cerebral arteriosclerosis 12.23 9.61 14 748719 299 89879415
Gastrointestinal tract mucosal discolouration 12.21 9.61 5 748728 15 89879699
Coronary artery perforation 12.21 9.61 5 748728 15 89879699
Hypertension neonatal 12.21 9.61 5 748728 15 89879699
Heart valve replacement 12.21 9.61 23 748710 781 89878933
Foetal hypokinesia 12.20 9.61 20 748713 607 89879107
Genital erosion 12.18 9.61 17 748716 446 89879268
Sexual dysfunction 12.18 9.61 13 748720 4791 89874923
Autoimmune hepatitis 12.16 9.61 135 748598 10216 89869498
Obstructive defaecation 12.15 9.61 13 748720 257 89879457
Pelvic haemorrhage 12.12 9.61 10 748723 140 89879574
Invasive ductal breast carcinoma 12.11 9.61 108 748625 7710 89872004
Musculoskeletal chest pain 12.09 9.61 269 748464 23481 89856233
Gastrointestinal arteriovenous malformation 12.09 9.61 19 748714 556 89879158
Wound dehiscence 12.07 9.61 86 748647 5736 89873978
Coagulation time prolonged 12.06 9.61 36 748697 1654 89878060
Nephropathy 12.04 9.61 123 748610 9112 89870602
Bronchiectasis 12.03 9.61 122 748611 22208 89857506
Tooth socket haemorrhage 12.03 9.61 7 748726 53 89879661
Spinal subarachnoid haemorrhage 12.02 9.61 4 748729 5 89879709
Pericarditis constrictive 12.01 9.61 19 748714 559 89879155
Haemoglobin abnormal 12.00 9.61 100 748633 7000 89872714
Trifascicular block 11.98 9.61 9 748724 109 89879605
Amnesia 11.98 9.61 754 747979 107751 89771963
Brain stem ischaemia 11.98 9.61 9 748724 109 89879605
Immune reconstitution inflammatory syndrome 11.96 9.61 25 748708 6994 89872720
Retinal exudates 11.95 9.61 21 748712 675 89879039
Cheyne-Stokes respiration 11.91 9.61 9 748724 110 89879604
Gastric mucosal lesion 11.90 9.61 20 748713 620 89879094
Hepatitis acute 11.89 9.61 140 748593 10747 89868967
Cardioactive drug level increased 11.88 9.61 45 748688 2339 89877375
Vertebral artery dissection 11.83 9.61 10 748723 145 89879569
Dyspnoea paroxysmal nocturnal 11.82 9.61 27 748706 1053 89878661
Terminal insomnia 11.81 9.61 29 748704 1186 89878528
Oxygen consumption decreased 11.80 9.61 14 748719 311 89879403
Spinal stenosis 11.79 9.61 206 748527 17218 89862496
Cardiac death 11.77 9.61 19 748714 569 89879145
Complication of device removal 11.77 9.61 21 748712 6234 89873480
Atheroembolism 11.75 9.61 5 748728 17 89879697
Rectal ulcer 11.74 9.61 33 748700 1465 89878249
Daydreaming 11.74 9.61 17 748716 462 89879252
Refusal of treatment by relative 11.74 9.61 14 748719 313 89879401
Pulse absent 11.73 9.61 88 748645 5967 89873747
Cholecystitis 11.72 9.61 202 748531 16838 89862876
Death 11.70 9.61 4072 744661 452479 89427235
Peripheral embolism 11.70 9.61 31 748702 1329 89878385
Polycythaemia 11.68 9.61 29 748704 1194 89878520
Vascular stenosis 11.67 9.61 18 748715 518 89879196
Radius fracture 11.67 9.61 65 748668 3979 89875735
Hysterosalpingo-oophorectomy 11.67 9.61 8 748725 83 89879631
Parkinsonism 11.66 9.61 172 748561 13893 89865821
Ulcer 11.65 9.61 355 748378 32527 89847187
Parainfluenzae virus infection 11.64 9.61 50 748683 2753 89876961
Decubitus ulcer 11.64 9.61 149 748584 11664 89868050
Chest wall haematoma 11.63 9.61 12 748721 227 89879487
Mood swings 11.62 9.61 112 748621 20590 89859124
Hypogammaglobulinaemia 11.61 9.61 47 748686 10627 89869087
Soft tissue haemorrhage 11.60 9.61 13 748720 271 89879443
Laryngeal haemorrhage 11.60 9.61 4 748729 6 89879708
Benign soft tissue neoplasm 11.60 9.61 4 748729 6 89879708
Neurofibroma 11.60 9.61 4 748729 6 89879708
ADAMTS13 activity decreased 11.60 9.61 11 748722 187 89879527
Nail discomfort 11.59 9.61 8 748725 84 89879630
Rectal ulcer haemorrhage 11.59 9.61 12 748721 228 89879486
Renal haematoma 11.59 9.61 12 748721 228 89879486
Colonic haematoma 11.59 9.61 6 748727 35 89879679
Cardiac function disturbance postoperative 11.59 9.61 6 748727 35 89879679
Acute lymphocytic leukaemia recurrent 11.58 9.61 4 748729 2717 89876997
Blood immunoglobulin G increased 11.57 9.61 52 748681 2920 89876794
Retinal pigment epitheliopathy 11.57 9.61 13 748720 272 89879442
Blood creatine phosphokinase abnormal 11.56 9.61 14 748719 318 89879396
Ascites 11.53 9.61 303 748430 47437 89832277
Cytomegalovirus infection reactivation 11.51 9.61 30 748703 7770 89871944
Bone disorder 11.50 9.61 261 748472 22859 89856855
Foot amputation 11.50 9.61 14 748719 320 89879394
Blood thyroid stimulating hormone increased 11.49 9.61 121 748612 9034 89870680
Poisoning 11.47 9.61 76 748657 15141 89864573
Pregnancy with contraceptive device 11.46 9.61 15 748718 5051 89874663
Jaw disorder 11.46 9.61 82 748651 5477 89874237
Gamma-glutamyltransferase increased 11.45 9.61 402 748331 37550 89842164
Postictal paralysis 11.42 9.61 13 748720 276 89879438
Urethral stenosis 11.42 9.61 13 748720 276 89879438
Oral mucosa atrophy 11.41 9.61 3 748730 0 89879714
Cholecystostomy 11.41 9.61 3 748730 0 89879714
Incision site ulcer 11.41 9.61 3 748730 0 89879714
Sternotomy 11.41 9.61 3 748730 0 89879714
Fallopian tube cancer metastatic 11.41 9.61 3 748730 0 89879714
Oesophageal mucosal hyperplasia 11.41 9.61 3 748730 0 89879714
Plasma cell disorder 11.41 9.61 3 748730 0 89879714
Blepharal papilloma 11.41 9.61 3 748730 0 89879714
Acid-base balance disorder mixed 11.41 9.61 3 748730 0 89879714
Puncture site reaction 11.41 9.61 3 748730 0 89879714
Meralgia paraesthetica 11.40 9.61 18 748715 529 89879185
Breast cancer female 11.39 9.61 74 748659 14812 89864902
Diet refusal 11.39 9.61 19 748714 585 89879129
Retching 11.39 9.61 222 748511 18937 89860777
Anosmia 11.36 9.61 128 748605 9720 89869994
Pulmonary valve disease 11.34 9.61 5 748728 19 89879695
Complications of transplanted heart 11.33 9.61 9 748724 119 89879595
Accidental overdose 11.33 9.61 310 748423 27963 89851751
Clostridium test positive 11.33 9.61 80 748653 5321 89874393
Pharyngeal haematoma 11.32 9.61 7 748726 60 89879654
Developmental glaucoma 11.32 9.61 7 748726 60 89879654
Incarcerated hernia 11.29 9.61 10 748723 155 89879559
Aortic intramural haematoma 11.27 9.61 9 748724 120 89879594
Dermatitis exfoliative generalised 11.24 9.61 18 748715 5575 89874139
Coronary artery embolism 11.23 9.61 11 748722 195 89879519
Arteriogram coronary abnormal 11.23 9.61 4 748729 7 89879707
Leukocoria 11.23 9.61 4 748729 7 89879707
Gastric ulcer helicobacter 11.23 9.61 4 748729 7 89879707
Blood chloride decreased 11.22 9.61 90 748643 6229 89873485
Anaemia postoperative 11.22 9.61 42 748691 2171 89877543
Transient global amnesia 11.21 9.61 21 748712 710 89879004
Dialysis 11.21 9.61 143 748590 11186 89868528
Gastric fistula 11.21 9.61 9 748724 121 89879593
Heart transplant 11.19 9.61 19 748714 594 89879120
Small intestine ulcer 11.17 9.61 15 748718 379 89879335
Hypercalcaemia 11.17 9.61 366 748367 33874 89845840
Pulmonary arteriovenous fistula 11.14 9.61 5 748728 20 89879694
Urea renal clearance decreased 11.14 9.61 5 748728 20 89879694
Choking sensation 11.14 9.61 63 748670 3879 89875835
Sodium retention 11.14 9.61 10 748723 158 89879556
Ruptured cerebral aneurysm 11.13 9.61 18 748715 540 89879174
Idiopathic intracranial hypertension 11.12 9.61 8 748725 3573 89876141
Peptic ulcer haemorrhage 11.10 9.61 27 748706 1097 89878617
Intention tremor 11.10 9.61 16 748717 433 89879281
Blood aldosterone increased 11.10 9.61 11 748722 198 89879516
Oral pain 11.09 9.61 351 748382 32332 89847382
Accident at home 11.09 9.61 10 748723 159 89879555
Productive cough 11.08 9.61 759 747974 76304 89803410
Coma scale abnormal 11.03 9.61 82 748651 5544 89874170
Lumbar vertebral fracture 11.03 9.61 102 748631 7356 89872358
Diabetic macroangiopathy 11.03 9.61 9 748724 124 89879590
Breech presentation 11.02 9.61 29 748704 1238 89878476
Cerebral artery thrombosis 10.96 9.61 16 748717 438 89879276
Aneurysm repair 10.95 9.61 5 748728 21 89879693
Hepatic embolisation 10.95 9.61 5 748728 21 89879693
Arterial rupture 10.94 9.61 15 748718 387 89879327
Hypoxia 10.93 9.61 716 748017 71683 89808031
Blood erythropoietin increased 10.89 9.61 4 748729 8 89879706
Haemorrhagic cholecystitis 10.89 9.61 4 748729 8 89879706
Basilar artery thrombosis 10.88 9.61 10 748723 163 89879551
Tracheal injury 10.88 9.61 10 748723 163 89879551
Malignant hypertension 10.88 9.61 28 748705 1179 89878535
Bundle branch block 10.86 9.61 24 748709 915 89878799
Peptic ulcer perforation 10.85 9.61 16 748717 442 89879272
Moyamoya disease 10.85 9.61 8 748725 94 89879620
Cystitis haemorrhagic 10.84 9.61 18 748715 5495 89874219
Extraocular muscle disorder 10.83 9.61 10 748723 164 89879550
Myelofibrosis 10.83 9.61 33 748700 1534 89878180
Saliva altered 10.82 9.61 15 748718 391 89879323
Preterm premature rupture of membranes 10.82 9.61 34 748699 1607 89878107
Product packaging issue 10.82 9.61 34 748699 1607 89878107
Nocturia 10.82 9.61 131 748602 10124 89869590
External ear disorder 10.82 9.61 6 748727 41 89879673
Product impurity 10.82 9.61 6 748727 41 89879673
Arterial insufficiency 10.79 9.61 11 748722 205 89879509
Arterial bypass operation 10.77 9.61 5 748728 22 89879692
Radiation overdose 10.77 9.61 5 748728 22 89879692
Morbid thoughts 10.75 9.61 21 748712 733 89878981
Pemphigoid 10.73 9.61 118 748615 8908 89870806
Tuberculin test positive 10.71 9.61 9 748724 3716 89875998
Urine viscosity increased 10.70 9.61 6 748727 42 89879672
Sinonasal obstruction 10.68 9.61 12 748721 251 89879463
Impaired quality of life 10.67 9.61 131 748602 23013 89856701
Facial bones fracture 10.66 9.61 60 748673 3687 89876027
Ketoacidosis 10.66 9.61 81 748652 5514 89874200
Head discomfort 10.66 9.61 192 748541 16141 89863573
Myxoedema coma 10.65 9.61 15 748718 397 89879317
Stridor 10.65 9.61 72 748661 4721 89874993
Blood homocysteine increased 10.64 9.61 12 748721 252 89879462
Oesophageal stenosis 10.64 9.61 61 748672 3775 89875939
Paraplegia 10.63 9.61 56 748677 3356 89876358
Decreased activity 10.63 9.61 109 748624 8083 89871631
Therapeutic response increased 10.59 9.61 16 748717 452 89879262
Ischaemic skin ulcer 10.58 9.61 6 748727 43 89879671
Vasoplegia syndrome 10.56 9.61 5 748728 2809 89876905
Haemorrhagic diathesis 10.54 9.61 80 748653 5444 89874270
Flank pain 10.52 9.61 220 748513 19002 89860712
Peritoneal haematoma 10.51 9.61 8 748725 99 89879615
Autoimmune myocarditis 10.50 9.61 12 748721 256 89879458
Second primary malignancy 10.49 9.61 47 748686 10331 89869383
Ovarian cyst 10.45 9.61 92 748641 17226 89862488
Mesenteric arterial occlusion 10.45 9.61 10 748723 172 89879542
Blood albumin decreased 10.43 9.61 196 748537 16607 89863107
Akathisia 10.42 9.61 52 748681 11107 89868607
Mucosal haemorrhage 10.42 9.61 31 748702 1422 89878292
Fibromuscular dysplasia 10.42 9.61 13 748720 305 89879409
Optic ischaemic neuropathy 10.38 9.61 35 748698 1717 89877997
Hypersomnia 10.38 9.61 242 748491 21289 89858425
Exfoliative rash 10.37 9.61 53 748680 3139 89876575
Stoma site inflammation 10.37 9.61 21 748712 753 89878961
Eye contusion 10.36 9.61 46 748687 2570 89877144
Bone deformity 10.35 9.61 18 748715 574 89879140
Haemodialysis complication 10.34 9.61 11 748722 216 89879498
Pulmonary valve incompetence 10.33 9.61 34 748699 1647 89878067
Temperature intolerance 10.32 9.61 148 748585 11882 89867832
Congestive hepatopathy 10.30 9.61 51 748682 2982 89876732
Injection site urticaria 10.30 9.61 97 748636 17914 89861800
Hypoxic-ischaemic encephalopathy 10.30 9.61 70 748663 4598 89875116
Malignant peritoneal neoplasm 10.29 9.61 21 748712 757 89878957
Mediastinal haemorrhage 10.29 9.61 4 748729 10 89879704
Postpericardiotomy syndrome 10.29 9.61 4 748729 10 89879704
Cutaneous lupus erythematosus 10.29 9.61 52 748681 3066 89876648
Central nervous system vasculitis 10.28 9.61 26 748707 1083 89878631
Retinal degeneration 10.28 9.61 26 748707 1083 89878631
Red blood cell abnormality 10.27 9.61 17 748716 520 89879194
Pulmonary artery dilatation 10.27 9.61 14 748719 359 89879355
Mouth swelling 10.25 9.61 81 748652 5581 89874133
Pulmonary tuberculosis 10.25 9.61 15 748718 4819 89874895
Limb discomfort 10.24 9.61 398 748335 37662 89842052
Iron deficiency 10.23 9.61 123 748610 9489 89870225
Hepatitis cholestatic 10.21 9.61 112 748621 8449 89871265
Hepatic haematoma 10.20 9.61 17 748716 523 89879191
Hyporesponsive to stimuli 10.20 9.61 33 748700 1584 89878130
Rectal adenocarcinoma 10.18 9.61 20 748713 701 89879013
Vascular graft infection 10.14 9.61 6 748727 47 89879667
Pyogenic granuloma 10.13 9.61 13 748720 314 89879400
Philadelphia positive acute lymphocytic leukaemia 10.11 9.61 5 748728 26 89879688
Fear of eating 10.11 9.61 15 748718 417 89879297
Vertebrobasilar insufficiency 10.10 9.61 11 748722 222 89879492
Dental caries 10.09 9.61 141 748592 11256 89868458
Cardioactive drug level above therapeutic 10.08 9.61 9 748724 141 89879573
Labyrinthitis 10.07 9.61 47 748686 2682 89877032
Dyspnoea at rest 10.07 9.61 71 748662 4720 89874994
Sickle cell anaemia with crisis 10.06 9.61 29 748704 7268 89872446
Procedural complication 10.05 9.61 83 748650 5795 89873919
Idiopathic pulmonary fibrosis 10.05 9.61 33 748700 1597 89878117
Vascular stent insertion 10.02 9.61 4 748729 11 89879703
Poor feeding infant 10.02 9.61 17 748716 531 89879183
Hypoperfusion 10.01 9.61 35 748698 1749 89877965
Essential tremor 10.00 9.61 30 748703 1382 89878332
Degenerative aortic valve disease 10.00 9.61 10 748723 182 89879532
Sepsis 10.00 9.61 1661 747072 178153 89701561
Intestinal haematoma 10.00 9.61 8 748725 107 89879607
Aspartate aminotransferase increased 9.99 9.61 984 747749 101953 89777761
Aortic surgery 9.96 9.61 5 748728 27 89879687
Abdominal rebound tenderness 9.96 9.61 5 748728 27 89879687
Virologic failure 9.94 9.61 3 748730 2221 89877493
Peritonitis bacterial 9.93 9.61 75 748658 5096 89874618
Gastric disorder 9.92 9.61 353 748380 33031 89846683
Intracranial mass 9.91 9.61 28 748705 1247 89878467
Lip haemorrhage 9.87 9.61 18 748715 596 89879118
Otitis externa 9.86 9.61 37 748696 1914 89877800
Stoma site dermatitis 9.86 9.61 12 748721 274 89879440
Stress ulcer 9.84 9.61 6 748727 50 89879664
Blood urea abnormal 9.84 9.61 23 748710 911 89878803
Sciatic nerve palsy 9.82 9.61 5 748728 28 89879686
Protein-losing gastroenteropathy 9.79 9.61 13 748720 325 89879389
Prerenal failure 9.79 9.61 39 748694 2076 89877638
Blood osmolarity abnormal 9.77 9.61 4 748729 12 89879702
Yellow skin 9.77 9.61 46 748687 2635 89877079
Bronchopulmonary aspergillosis allergic 9.76 9.61 10 748723 3756 89875958
Pancreatic neoplasm 9.76 9.61 24 748709 982 89878732
Faeces pale 9.74 9.61 37 748696 1926 89877788
Enterocolitis haemorrhagic 9.74 9.61 34 748699 1698 89878016
Drug hypersensitivity 9.73 9.61 3561 745172 460048 89419666
Aspartate aminotransferase 9.73 9.61 20 748713 725 89878989
Implant site haematoma 9.72 9.61 7 748726 79 89879635
Hidradenitis 9.70 9.61 13 748720 4334 89875380
Carbuncle 9.70 9.61 30 748703 1406 89878308
Neck deformity 9.70 9.61 3 748730 2186 89877528
Aldolase increased 9.68 9.61 9 748724 149 89879565
Coronary ostial stenosis 9.65 9.61 7 748726 80 89879634
Creatinine renal clearance increased 9.65 9.61 53 748680 3228 89876486

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2342.82 12.85 5867 702347 118142 41794979
Gastrointestinal haemorrhage 1989.94 12.85 4760 703454 92966 41820155
Coronary artery disease 1608.33 12.85 3062 705152 50658 41862463
Off label use 1449.16 12.85 5598 702616 632737 41280384
Acute myocardial infarction 1372.04 12.85 3004 705210 55161 41857960
Drug ineffective 1326.07 12.85 5692 702522 624505 41288616
Labelled drug-drug interaction medication error 1083.32 12.85 1316 706898 14266 41898855
Cardiac failure congestive 903.79 12.85 3302 704912 82300 41830821
Drug abuse 855.22 12.85 335 707879 104436 41808685
Melaena 822.88 12.85 1920 706294 36826 41876295
Angina pectoris 820.05 12.85 1738 706476 31158 41881963
Upper gastrointestinal haemorrhage 771.75 12.85 1615 706599 28684 41884437
Cerebrovascular accident 713.43 12.85 3352 704862 93808 41819313
Febrile neutropenia 708.56 12.85 1250 706964 184453 41728668
Vascular stent thrombosis 690.41 12.85 510 707704 2732 41910389
Toxicity to various agents 688.44 12.85 1765 706449 227371 41685750
Completed suicide 651.47 12.85 398 707816 96067 41817054
Angina unstable 607.03 12.85 846 707368 10602 41902519
Gastric haemorrhage 587.57 12.85 797 707417 9718 41903403
Product use in unapproved indication 517.41 12.85 1469 706745 182987 41730134
Chest pain 504.20 12.85 4004 704210 135526 41777595
Syncope 468.18 12.85 3041 705173 96365 41816756
Cerebral haemorrhage 438.05 12.85 1535 706679 37431 41875690
Haemorrhage 415.01 12.85 2049 706165 58514 41854607
Coronary artery bypass 414.63 12.85 454 707760 4356 41908765
Coronary arterial stent insertion 391.12 12.85 403 707811 3582 41909539
Haematuria 390.72 12.85 1948 706266 55851 41857270
Lower gastrointestinal haemorrhage 387.94 12.85 667 707547 10141 41902980
Disease progression 386.69 12.85 1166 707048 142490 41770631
Haematemesis 373.16 12.85 1228 706986 28971 41884150
Coronary artery occlusion 369.20 12.85 659 707555 10338 41902783
Coronary artery stenosis 367.91 12.85 637 707577 9742 41903379
Dizziness 365.83 12.85 5994 702220 243260 41669861
Treatment failure 334.26 12.85 328 707886 62296 41850825
Thrombosis in device 334.07 12.85 332 707882 2814 41910307
Subdural haematoma 319.82 12.85 978 707236 22160 41890961
Myelosuppression 319.18 12.85 136 708078 40325 41872796
Haemorrhage intracranial 291.33 12.85 782 707432 16410 41896711
Neutropenia 283.32 12.85 2044 706170 197387 41715734
Myocardial ischaemia 279.20 12.85 786 707428 16976 41896145
Haematoma 276.21 12.85 1058 707156 26965 41886156
Gastric ulcer 274.31 12.85 795 707419 17467 41895654
Rhabdomyolysis 273.88 12.85 2225 705989 75794 41837327
Rectal haemorrhage 273.40 12.85 1581 706633 48025 41865096
Death 270.82 12.85 5872 702342 465313 41447808
Condition aggravated 270.71 12.85 2898 705316 257856 41655265
Transient ischaemic attack 261.32 12.85 1183 707031 32556 41880565
Malignant neoplasm progression 258.99 12.85 927 707287 107473 41805648
Atrial fibrillation 258.76 12.85 3496 704718 136097 41777024
Epistaxis 247.77 12.85 1930 706284 64896 41848225
Blood loss anaemia 245.53 12.85 517 707697 9219 41903902
Cytokine release syndrome 242.50 12.85 229 707985 44298 41868823
Pyrexia 240.45 12.85 4862 703352 389180 41523941
Acute coronary syndrome 226.04 12.85 650 707564 14215 41898906
Anaemia 224.91 12.85 6172 702042 274106 41639015
Plasma cell myeloma 224.66 12.85 1457 706757 46121 41867000
Intentional product misuse 216.03 12.85 439 707775 61461 41851660
Fall 210.26 12.85 5241 702973 229279 41683842
Dyspnoea 209.47 12.85 9168 699046 433453 41479668
Haematochezia 208.54 12.85 1673 706541 56763 41856358
Faeces discoloured 206.71 12.85 688 707526 16326 41896795
Drug ineffective for unapproved indication 205.05 12.85 280 707934 45883 41867238
Mucosal inflammation 203.11 12.85 316 707898 49058 41864063
Duodenal ulcer 195.56 12.85 546 707668 11733 41901388
Drug dependence 192.18 12.85 123 708091 28971 41884150
Aspirin-exacerbated respiratory disease 186.19 12.85 95 708119 218 41912903
Gastritis erosive 180.14 12.85 359 707855 6144 41906977
Vascular stent stenosis 180.03 12.85 151 708063 1001 41912120
Post procedural haemorrhage 177.77 12.85 443 707771 8869 41904252
Haemoglobin decreased 176.15 12.85 3137 705077 129334 41783787
Hepatic cytolysis 168.57 12.85 120 708094 26724 41886397
Multiple organ dysfunction syndrome 166.03 12.85 939 707275 96096 41817025
Subarachnoid haemorrhage 165.08 12.85 573 707641 13899 41899222
Sepsis 163.68 12.85 2329 705885 197005 41716116
Therapeutic product effect incomplete 161.27 12.85 619 707595 70320 41842801
Therapy partial responder 156.77 12.85 68 708146 19953 41893168
Cytomegalovirus infection 155.89 12.85 184 708030 32122 41880999
Gastric ulcer haemorrhage 154.08 12.85 325 707889 5802 41907319
Asthenia 153.48 12.85 5908 702306 274885 41638236
Bronchopulmonary aspergillosis 150.53 12.85 67 708147 19362 41893759
Angioedema 149.83 12.85 1213 707001 41264 41871857
Mitral valve incompetence 149.11 12.85 606 707608 15883 41897238
Drug use disorder 149.04 12.85 5 708209 10328 41902793
Sedation 146.59 12.85 174 708040 30301 41882820
Neurotoxicity 140.46 12.85 112 708102 23539 41889582
Intentional product use issue 139.81 12.85 665 707549 71168 41841953
Carotid artery stenosis 139.79 12.85 291 707923 5145 41907976
Bradycardia 138.69 12.85 2092 706122 83392 41829729
Infusion related reaction 136.65 12.85 533 707681 60273 41852848
Coronary artery thrombosis 136.48 12.85 179 708035 2107 41911014
Cardiac failure 136.21 12.85 2514 705700 104342 41808779
Pancytopenia 135.42 12.85 1276 706938 116467 41796654
Haemophagocytic lymphohistiocytosis 134.77 12.85 67 708147 18155 41894966
Incorrect route of product administration 134.68 12.85 123 708091 24182 41888939
Septic shock 134.63 12.85 930 707284 90742 41822379
Dyspnoea exertional 131.94 12.85 1344 706870 48804 41864317
Ascites 131.78 12.85 490 707724 56188 41856933
Respiratory depression 131.28 12.85 75 708139 18793 41894328
Coronary artery restenosis 130.13 12.85 114 708100 808 41912313
Ischaemic cardiomyopathy 129.51 12.85 315 707899 6207 41906914
Haemorrhagic stroke 128.74 12.85 340 707874 7062 41906059
Myalgia 127.91 12.85 2276 705938 93804 41819317
Graft versus host disease 127.73 12.85 29 708185 12896 41900225
Drug intolerance 127.64 12.85 797 707417 79627 41833494
Cerebral infarction 127.20 12.85 921 707293 30248 41882873
Appendicitis 125.73 12.85 95 708119 20518 41892603
Bone marrow failure 124.80 12.85 224 707990 32869 41880252
Vascular graft 124.04 12.85 141 708073 1415 41911706
Somnolence 123.15 12.85 1628 706586 139477 41773644
Injection site pain 122.74 12.85 518 707696 57280 41855841
Respiratory symptom 122.37 12.85 19 708195 11087 41902034
Product administration error 122.29 12.85 616 707598 17727 41895394
Product use issue 121.59 12.85 761 707453 75990 41837131
Psychotic disorder 121.01 12.85 186 708028 29022 41884099
Serotonin syndrome 120.68 12.85 151 708063 25694 41887427
Ischaemic stroke 120.10 12.85 705 707509 21528 41891593
Bacterial infection 118.93 12.85 174 708040 27705 41885416
Hyperphosphataemia 117.39 12.85 35 708179 12969 41900152
Diverticulum intestinal haemorrhagic 117.22 12.85 193 708021 2826 41910295
Haemorrhagic arteriovenous malformation 116.74 12.85 75 708139 306 41912815
Duodenal ulcer haemorrhage 115.84 12.85 281 707933 5527 41907594
Acute graft versus host disease 114.98 12.85 5 708209 8210 41904911
Pathogen resistance 114.54 12.85 25 708189 11425 41901696
Small intestinal haemorrhage 114.49 12.85 166 708048 2162 41910959
Fatigue 112.89 12.85 8547 699667 427094 41486027
Pneumocystis jirovecii pneumonia 112.55 12.85 152 708062 25029 41888092
Poisoning 111.83 12.85 52 708162 14647 41898474
Hospitalisation 111.64 12.85 749 707465 73581 41839540
C-reactive protein abnormal 111.28 12.85 12 708202 9249 41903872
Cytomegalovirus infection reactivation 110.62 12.85 25 708189 11153 41901968
Acute graft versus host disease in skin 109.22 12.85 3 708211 7421 41905700
Infective pulmonary exacerbation of cystic fibrosis 108.63 12.85 5 708209 7813 41905308
Shock haemorrhagic 106.56 12.85 543 707671 15699 41897422
Overdose 105.30 12.85 1179 707035 104085 41809036
Drug resistance 104.70 12.85 261 707953 33987 41879134
Suicide attempt 104.28 12.85 403 707811 45697 41867424
Akathisia 104.18 12.85 23 708191 10428 41902693
Poisoning deliberate 103.69 12.85 21 708193 10113 41903008
Cardiac disorder 103.40 12.85 1256 706958 47676 41865445
Seizure 102.62 12.85 1398 706816 119163 41793958
Status epilepticus 99.98 12.85 68 708146 15510 41897611
Intraventricular haemorrhage 99.97 12.85 208 708006 3676 41909445
Neuroleptic malignant syndrome 99.68 12.85 126 708088 21346 41891775
COVID-19 99.59 12.85 1342 706872 114606 41798515
Suicidal ideation 99.58 12.85 436 707778 47725 41865396
Occult blood positive 99.25 12.85 219 707995 4038 41909083
Neoplasm progression 97.51 12.85 210 708004 28790 41884331
Stomatitis 97.29 12.85 467 707747 49862 41863259
Haematotoxicity 96.59 12.85 31 708183 10954 41902167
Immune reconstitution inflammatory syndrome 95.85 12.85 25 708189 10118 41903003
Inappropriate schedule of product administration 95.57 12.85 1075 707139 94827 41818294
Gastritis 95.07 12.85 703 707511 23244 41889877
Retroperitoneal haematoma 95.01 12.85 177 708037 2874 41910247
Hypotension 94.84 12.85 5210 703004 252421 41660700
Multiple-drug resistance 94.69 12.85 7 708207 7315 41905806
Presyncope 94.53 12.85 667 707547 21720 41891401
Haemorrhagic transformation stroke 94.40 12.85 132 708082 1659 41911462
Iron deficiency anaemia 94.15 12.85 448 707766 12591 41900530
Aspergillus infection 94.04 12.85 75 708139 15762 41897359
Venoocclusive liver disease 92.50 12.85 28 708186 10274 41902847
Drug reaction with eosinophilia and systemic symptoms 92.50 12.85 372 707842 41703 41871418
Subdural haemorrhage 91.89 12.85 189 708025 3312 41909809
Diastolic dysfunction 91.70 12.85 290 707924 6693 41906428
Lymphopenia 90.59 12.85 136 708078 21427 41891694
Pericardial haemorrhage 89.38 12.85 189 708025 3380 41909741
No adverse event 88.97 12.85 340 707874 38681 41874440
Ventricular tachycardia 86.97 12.85 824 707390 29336 41883785
Adenovirus infection 86.67 12.85 7 708207 6802 41906319
BK virus infection 86.22 12.85 20 708194 8764 41904357
Accidental exposure to product 85.31 12.85 129 708085 20264 41892857
Intercepted product preparation error 85.25 12.85 11 708203 7378 41905743
Diverticulum 84.63 12.85 297 707917 7244 41905877
Muscle spasms 84.47 12.85 1948 706266 84096 41829025
Infection 84.07 12.85 1332 706882 110736 41802385
Aplastic anaemia 83.65 12.85 51 708163 12333 41900788
Coma 83.26 12.85 534 707680 53020 41860101
Product monitoring error 82.94 12.85 209 708005 4214 41908907
Hypoglycaemia 81.80 12.85 1424 706790 58430 41854691
Vascular pseudoaneurysm 81.55 12.85 155 708059 2557 41910564
Immune effector cell-associated neurotoxicity syndrome 80.91 12.85 28 708186 9433 41903688
Intentional self-injury 79.50 12.85 81 708133 15121 41898000
Leukopenia 79.21 12.85 826 707388 73920 41839201
Febrile bone marrow aplasia 79.04 12.85 35 708179 10146 41902975
Chest discomfort 78.68 12.85 1490 706724 62126 41850995
Suspected suicide 77.19 12.85 7 708207 6192 41906929
Hypophosphataemia 76.98 12.85 144 708070 20801 41892320
Cytomegalovirus viraemia 76.97 12.85 38 708176 10339 41902782
Gastrointestinal vascular malformation haemorrhagic 76.60 12.85 81 708133 744 41912377
Electrocardiogram abnormal 76.50 12.85 353 707861 9792 41903329
Tumour lysis syndrome 76.40 12.85 159 708055 22072 41891049
Hiatus hernia 76.12 12.85 313 707901 8247 41904874
Blood phosphorus increased 76.03 12.85 58 708156 12467 41900654
Miosis 75.75 12.85 67 708147 13379 41899742
Internal haemorrhage 75.70 12.85 230 707984 5191 41907930
Contusion 75.38 12.85 1046 707168 40939 41872182
Therapeutic response decreased 74.74 12.85 338 707876 36674 41876447
Post transplant lymphoproliferative disorder 74.60 12.85 29 708185 9091 41904030
Stent placement 73.52 12.85 226 707988 5134 41907987
Hemiplegia 73.17 12.85 292 707922 7587 41905534
Peripheral vascular disorder 72.76 12.85 224 707990 5093 41908028
Graft versus host disease in gastrointestinal tract 72.42 12.85 3 708211 5140 41907981
Intermittent claudication 72.27 12.85 141 708073 2374 41910747
Peripheral arterial occlusive disease 72.21 12.85 264 707950 6574 41906547
Post procedural haematoma 71.51 12.85 110 708104 1515 41911606
Graft versus host disease in skin 70.31 12.85 4 708210 5208 41907913
Pseudomonas infection 70.27 12.85 97 708117 15826 41897295
Neuralgia 69.72 12.85 207 708007 25440 41887681
Oedema peripheral 69.64 12.85 2844 705370 133232 41779889
Product dose omission issue 69.62 12.85 1992 706222 152373 41760748
Ventricular extrasystoles 69.37 12.85 420 707794 12970 41900151
Neutrophil count decreased 68.75 12.85 697 707517 62718 41850403
Substance abuse 68.53 12.85 31 708183 8874 41904247
Tricuspid valve incompetence 68.39 12.85 365 707849 10748 41902373
International normalised ratio increased 68.35 12.85 1153 707061 47015 41866106
Muscle haemorrhage 68.23 12.85 186 708028 3939 41909182
Mite allergy 67.68 12.85 4 708210 5042 41908079
Posterior reversible encephalopathy syndrome 67.40 12.85 68 708146 12753 41900368
Chronic graft versus host disease 67.08 12.85 10 708204 6015 41907106
Hemiparesis 66.65 12.85 506 707708 16870 41896251
Gastrooesophageal reflux disease 66.57 12.85 1085 707129 43938 41869183
Aortic aneurysm 66.02 12.85 279 707935 7444 41905677
Cardiac failure chronic 65.81 12.85 325 707889 9276 41903845
Vomiting 65.60 12.85 4044 704170 285679 41627442
Therapeutic response shortened 65.59 12.85 77 708137 13477 41899644
Retroperitoneal haemorrhage 65.46 12.85 155 708059 3000 41910121
Arterial haemorrhage 65.40 12.85 91 708123 1138 41911983
Therapy non-responder 64.88 12.85 570 707644 52789 41860332
Spinal epidural haematoma 64.73 12.85 55 708159 372 41912749
Mallory-Weiss syndrome 64.20 12.85 101 708113 1420 41911701
Exposure to toxic agent 64.10 12.85 5 708209 4999 41908122
Stress 63.65 12.85 451 707763 43761 41869360
Spirometry abnormal 63.57 12.85 6 708208 5140 41907981
Thrombotic microangiopathy 63.30 12.85 92 708122 14690 41898431
Syringe issue 62.46 12.85 32 708182 8524 41904597
Aggression 61.40 12.85 455 707759 43708 41869413
Neuritis 61.37 12.85 14 708200 6206 41906915
Drug withdrawal syndrome 60.71 12.85 171 708043 21378 41891743
Ventricular hypokinesia 60.65 12.85 251 707963 6633 41906488
Epstein-Barr virus infection 60.28 12.85 44 708170 9674 41903447
Acute myeloid leukaemia 60.23 12.85 180 708034 22076 41891045
Exposure during pregnancy 59.44 12.85 34 708180 8514 41904607
Sleep disorder 59.26 12.85 512 707702 47583 41865538
Hypogammaglobulinaemia 59.23 12.85 66 708148 11825 41901296
Blood glucose increased 59.13 12.85 1624 706590 72075 41841046
Abdominal wall haematoma 58.19 12.85 123 708091 2199 41910922
Percutaneous coronary intervention 57.83 12.85 43 708171 233 41912888
Extradural haematoma 57.42 12.85 90 708124 1261 41911860
Thrombocytopenia 57.38 12.85 2580 705634 187699 41725422
Loss of consciousness 57.27 12.85 1972 706242 90382 41822739
Rash maculo-papular 57.25 12.85 376 707838 37127 41875994
Product prescribing error 57.23 12.85 675 707539 25437 41887684
Device leakage 57.04 12.85 52 708162 10233 41902888
Thalamus haemorrhage 56.80 12.85 81 708133 1038 41912083
Blood creatine phosphokinase increased 56.65 12.85 1123 707091 47215 41865906
Drug hypersensitivity 56.56 12.85 1239 706975 98150 41814971
Encephalopathy 56.44 12.85 428 707786 40905 41872216
Intentional overdose 56.41 12.85 564 707650 50892 41862229
Multiple injuries 56.32 12.85 108 708106 1794 41911327
Generalised tonic-clonic seizure 56.24 12.85 236 707978 26143 41886978
Enthesopathy 56.16 12.85 7 708207 4821 41908300
Thrombosis 55.33 12.85 1511 706703 67000 41846121
Conjunctivitis allergic 55.04 12.85 15 708199 5896 41907225
Myocardial rupture 54.78 12.85 38 708176 181 41912940
Cystitis haemorrhagic 54.12 12.85 27 708187 7302 41905819
Psoriatic arthropathy 54.08 12.85 222 707992 24745 41888376
Muscular weakness 54.08 12.85 1792 706422 81706 41831415
Virologic failure 54.08 12.85 3 708211 3991 41909130
Withdrawal syndrome 53.93 12.85 102 708112 14673 41898448
Peptic ulcer 53.62 12.85 151 708063 3261 41909860
Embolic stroke 53.57 12.85 195 708019 4845 41908276
Acute graft versus host disease in intestine 53.40 12.85 3 708211 3948 41909173
Mucormycosis 53.22 12.85 26 708188 7117 41906004
Traumatic intracranial haemorrhage 53.18 12.85 64 708150 686 41912435
Respiratory arrest 53.04 12.85 267 707947 28157 41884964
Venoocclusive disease 52.83 12.85 3 708211 3912 41909209
Vascular graft occlusion 52.74 12.85 57 708157 538 41912583
Musculoskeletal stiffness 52.72 12.85 660 707554 57105 41856016
Hyperkalaemia 51.91 12.85 1726 706488 78732 41834389
Agranulocytosis 51.89 12.85 297 707917 30315 41882806
Nocturia 51.79 12.85 362 707852 11750 41901371
Gastrointestinal arteriovenous malformation 51.79 12.85 45 708169 315 41912806
Myasthenia gravis 51.67 12.85 120 708094 16017 41897104
Red blood cell sedimentation rate abnormal 51.58 12.85 3 708211 3833 41909288
Haemorrhagic cholecystitis 51.40 12.85 32 708182 122 41912999
Arterial occlusive disease 51.38 12.85 177 708037 4276 41908845
Chromaturia 51.26 12.85 447 707767 15542 41897579
Interstitial lung disease 50.94 12.85 957 707257 77505 41835616
Lymphocyte count decreased 50.89 12.85 263 707951 27546 41885575
Ecchymosis 50.73 12.85 259 707955 7493 41905628
Drug withdrawal syndrome neonatal 50.61 12.85 7 708207 4454 41908667
Eye haemorrhage 50.60 12.85 186 708028 4644 41908477
Behaviour disorder 50.58 12.85 27 708187 7027 41906094
Blood pressure decreased 50.41 12.85 1298 706916 57034 41856087
Gingival bleeding 50.40 12.85 276 707938 8209 41904912
Bronchopulmonary aspergillosis allergic 50.35 12.85 8 708206 4590 41908531
Duodenitis 50.07 12.85 204 708010 5352 41907769
Bundle branch block left 50.06 12.85 227 707987 6249 41906872
Systemic infection 50.03 12.85 195 708019 5010 41908111
Orthostatic hypotension 49.86 12.85 749 707465 29821 41883300
Nodule 49.85 12.85 82 708132 12452 41900669
Cerebellar haemorrhage 49.69 12.85 96 708118 1604 41911517
Enterococcal infection 49.54 12.85 77 708137 11962 41901159
Methaemoglobinaemia 49.53 12.85 17 708197 5757 41907364
Fungal infection 49.51 12.85 165 708049 19557 41893564
C-reactive protein increased 49.48 12.85 750 707464 62810 41850311
Oesophageal intramural haematoma 49.24 12.85 20 708194 19 41913102
Progressive multifocal leukoencephalopathy 49.20 12.85 72 708142 11464 41901657
Synovitis 48.86 12.85 117 708097 15450 41897671
Chronic kidney disease 48.67 12.85 1077 707137 46164 41866957
Angiocardiogram 48.56 12.85 36 708178 194 41912927
Gastrointestinal ulcer 48.39 12.85 101 708113 1789 41911332
Haemorrhage urinary tract 48.28 12.85 107 708107 1979 41911142
Obsessive-compulsive disorder 48.07 12.85 26 708188 6717 41906404
Klebsiella infection 48.06 12.85 71 708143 11261 41901860
Toxic epidermal necrolysis 47.82 12.85 255 707959 26495 41886626
Sinus node dysfunction 47.66 12.85 182 708032 4630 41908491
Cardiac tamponade 47.43 12.85 225 707989 6315 41906806
Pain 47.41 12.85 3465 704749 241383 41671738
Blood bilirubin increased 47.20 12.85 461 707753 41791 41871330
Mediastinal haematoma 47.12 12.85 28 708186 96 41913025
Gastritis haemorrhagic 47.07 12.85 93 708121 1581 41911540
Stenotrophomonas infection 46.62 12.85 4 708210 3700 41909421
Hepatojugular reflux 46.61 12.85 57 708157 622 41912499
Coronary artery perforation 46.49 12.85 24 708190 57 41913064
Acute lymphocytic leukaemia recurrent 46.41 12.85 4 708210 3687 41909434
Agitation 46.34 12.85 770 707444 63544 41849577
Large intestinal haemorrhage 46.16 12.85 94 708120 1635 41911486
Cerebral haematoma 45.90 12.85 200 708014 5410 41907711
Euphoric mood 45.83 12.85 25 708189 6428 41906693
Ejection fraction decreased 45.80 12.85 565 707649 21522 41891599
Candida infection 45.66 12.85 194 708020 21416 41891705
Vascular stent occlusion 45.40 12.85 35 708179 202 41912919
Basal ganglia haemorrhage 45.19 12.85 71 708143 997 41912124
Ventricular hypertrophy 45.14 12.85 179 708035 4637 41908484
High density lipoprotein decreased 45.05 12.85 155 708059 3742 41909379
Hyperbilirubinaemia 44.99 12.85 183 708031 20452 41892669
Rheumatoid arthritis 44.95 12.85 469 707745 41971 41871150
Acute respiratory distress syndrome 44.88 12.85 304 707910 29804 41883317
Schizophrenia 44.84 12.85 66 708148 10484 41902637
Bacteraemia 44.60 12.85 239 707975 24801 41888320
Transplant rejection 44.35 12.85 100 708114 13488 41899633
Iron deficiency 44.33 12.85 72 708142 10989 41902132
Heparin-induced thrombocytopenia 44.29 12.85 222 707992 6375 41906746
Drug interaction 44.17 12.85 5075 703139 261924 41651197
Injection site reaction 44.11 12.85 125 708089 15596 41897525
Procedural haemorrhage 43.93 12.85 125 708089 2716 41910405
Electrocardiogram ST segment depression 43.87 12.85 122 708092 2615 41910506
Helicobacter gastritis 43.86 12.85 80 708134 1277 41911844
Basilar artery thrombosis 43.63 12.85 35 708179 216 41912905
Vitreous haemorrhage 43.59 12.85 122 708092 2625 41910496
Electrocardiogram ST segment elevation 43.56 12.85 205 708009 5734 41907387
Carotid artery disease 43.53 12.85 63 708151 819 41912302
Lacunar infarction 43.37 12.85 136 708078 3124 41909997
Hyperthermia 43.15 12.85 90 708124 12484 41900637
Aortic valve incompetence 43.01 12.85 219 707995 6329 41906792
Neutrophil count increased 42.95 12.85 176 708038 19628 41893493
Cerebral artery occlusion 42.92 12.85 61 708153 779 41912342
Skin toxicity 42.82 12.85 28 708186 6521 41906600
Left ventricular failure 42.66 12.85 206 708008 5825 41907296
Drug effective for unapproved indication 42.50 12.85 29 708185 6604 41906517
Hepatic failure 42.43 12.85 416 707798 37684 41875437
Foetal exposure during pregnancy 42.26 12.85 543 707671 46768 41866353
Full blood count decreased 42.23 12.85 525 707689 20035 41893086
Coronary artery aneurysm 41.98 12.85 26 708188 98 41913023
Dystonia 41.85 12.85 94 708120 12696 41900425
Gastrointestinal ulcer haemorrhage 41.71 12.85 59 708155 750 41912371
Ulcer haemorrhage 41.53 12.85 131 708083 3019 41910102
Loss of personal independence in daily activities 41.50 12.85 580 707634 49236 41863885
Large intestine polyp 41.45 12.85 280 707934 8985 41904136
Anal fistula 41.39 12.85 26 708188 6187 41906934
Myopathy 41.19 12.85 379 707835 13382 41899739
Colitis 41.05 12.85 536 707678 46036 41867085
Occult blood 40.96 12.85 65 708149 921 41912200
Irritability 40.94 12.85 286 707928 27842 41885279
Sickle cell anaemia with crisis 40.91 12.85 15 708199 4875 41908246
Atrioventricular block complete 40.86 12.85 326 707888 11038 41902083
Fat embolism 40.85 12.85 30 708184 159 41912962
Cardiac aneurysm 40.80 12.85 69 708145 1034 41912087
Arteriosclerosis 40.75 12.85 468 707746 17521 41895600
Hypertensive crisis 40.72 12.85 300 707914 9906 41903215
Haemobilia 40.58 12.85 44 708170 417 41912704
Hypoxia 40.54 12.85 867 707347 68919 41844202
Splenic haematoma 40.46 12.85 29 708185 147 41912974
Device related infection 40.45 12.85 186 708028 20093 41893028
Tongue haematoma 40.41 12.85 25 708189 94 41913027
Aplasia 40.28 12.85 15 708199 4828 41908293
Haematocrit decreased 40.23 12.85 809 707405 34099 41879022
Cytopenia 40.17 12.85 152 708062 17345 41895776
Disinhibition 40.00 12.85 8 708206 3887 41909234
Sinus bradycardia 39.97 12.85 400 707814 14453 41898668
Abnormal behaviour 39.96 12.85 266 707948 26185 41886936
Lung disorder 39.91 12.85 558 707656 47365 41865756
Sleep disorder due to a general medical condition 39.82 12.85 152 708062 17301 41895820
Glomerular filtration rate decreased 39.59 12.85 431 707783 15920 41897201
Polyomavirus-associated nephropathy 39.52 12.85 22 708192 5593 41907528
Arthralgia 39.46 12.85 2906 705308 202332 41710789
Peripheral artery stenosis 39.36 12.85 61 708153 846 41912275
Cerebrovascular disorder 39.23 12.85 92 708122 1769 41911352
Peptic ulcer haemorrhage 39.19 12.85 53 708161 644 41912477
Head injury 39.08 12.85 518 707696 20064 41893057
Eosinophilic granulomatosis with polyangiitis 38.74 12.85 52 708162 8586 41904535
Splenic rupture 38.70 12.85 85 708129 1562 41911559
Systemic candida 38.67 12.85 20 708194 5299 41907822
Urinary bladder haemorrhage 38.60 12.85 91 708123 1756 41911365
Swelling 38.28 12.85 661 707553 54224 41858897
Left ventricular dysfunction 38.16 12.85 324 707890 11177 41901944
Joint swelling 38.10 12.85 850 707364 67172 41845949
Erythema 38.09 12.85 1450 706764 107343 41805778
Swollen tongue 37.72 12.85 528 707686 20703 41892418
Epilepsy 37.65 12.85 267 707947 25904 41887217
Bradypnoea 37.57 12.85 13 708201 4380 41908741
Coronary angioplasty 37.54 12.85 40 708174 371 41912750
Pneumonia cytomegaloviral 37.43 12.85 11 708203 4115 41909006
Haemorrhagic cerebral infarction 37.38 12.85 59 708155 832 41912289
Drug dose omission by device 37.36 12.85 26 708188 5860 41907261
Nausea 37.26 12.85 5908 702306 390891 41522230
Ventricular dysfunction 37.20 12.85 161 708053 4342 41908779
Oesophageal ulcer 37.09 12.85 142 708072 3617 41909504
Hepatocellular injury 36.84 12.85 236 707978 23442 41889679
Low density lipoprotein increased 36.51 12.85 181 708033 5174 41907947
Sudden cardiac death 36.10 12.85 145 708069 3779 41909342
Viral mutation identified 36.02 12.85 6 708208 3325 41909796
Increased tendency to bruise 35.91 12.85 156 708058 4214 41908907
Blood creatinine increased 35.83 12.85 2201 706013 107802 41805319
Haemoptysis 35.80 12.85 1013 707201 45154 41867967
Psychomotor skills impaired 35.75 12.85 21 708193 5183 41907938
Adrenal insufficiency 35.75 12.85 177 708037 18747 41894374
Body height decreased 35.74 12.85 149 708065 3951 41909170
Cardio-respiratory arrest 35.67 12.85 723 707491 57913 41855208
Atrial flutter 35.64 12.85 441 707773 16810 41896311
Hyperammonaemia 35.64 12.85 47 708167 7819 41905302
Autism spectrum disorder 35.58 12.85 4 708210 2984 41910137
Sinus arrest 35.45 12.85 97 708117 2059 41911062
Forced expiratory volume decreased 35.18 12.85 45 708169 7585 41905536
Respiratory distress 35.16 12.85 486 707728 41334 41871787
Hepatitis B reactivation 35.13 12.85 16 708198 4562 41908559
Colorectal cancer 35.08 12.85 20 708194 5018 41908103
Wrong technique in product usage process 34.94 12.85 498 707716 42137 41870984
Ageusia 34.92 12.85 320 707894 11285 41901836
Haemorrhage subcutaneous 34.85 12.85 110 708104 2536 41910585
Paranoia 34.76 12.85 118 708096 13908 41899213
Product storage error 34.74 12.85 84 708130 11056 41902065
Escherichia infection 34.70 12.85 87 708127 11309 41901812
Peripheral ischaemia 34.61 12.85 205 708009 6280 41906841
Blood test abnormal 34.48 12.85 105 708109 12801 41900320
Lymphoma 34.47 12.85 122 708092 14199 41898922
Angioplasty 34.32 12.85 62 708152 982 41912139
Cytomegalovirus chorioretinitis 34.03 12.85 17 708197 4594 41908527
Haemorrhagic erosive gastritis 33.89 12.85 30 708184 216 41912905
Bladder tamponade 33.59 12.85 47 708167 591 41912530
Rebound effect 33.52 12.85 44 708170 7335 41905786
Therapeutic product effect decreased 33.26 12.85 454 707760 38696 41874425
Idiopathic pulmonary fibrosis 33.10 12.85 158 708056 4446 41908675
Blood urine present 33.05 12.85 319 707895 11414 41901707
Haemorrhagic diathesis 32.73 12.85 122 708092 3067 41910054
Haemorrhagic infarction 32.67 12.85 42 708172 484 41912637
Hepatitis B 32.61 12.85 38 708176 6673 41906448
Ventricular arrhythmia 32.55 12.85 197 708017 6082 41907039
Balance disorder 32.51 12.85 1029 707185 46616 41866505
Arterial restenosis 32.48 12.85 17 708197 42 41913079
Extrapyramidal disorder 32.46 12.85 151 708063 16261 41896860
Drug screen positive 32.39 12.85 14 708200 4117 41909004
Accidental death 32.36 12.85 6 708208 3077 41910044
Antineutrophil cytoplasmic antibody positive 32.35 12.85 16 708198 4349 41908772
Inflammation 32.29 12.85 383 707831 33464 41879657
Incorrect dose administered 32.28 12.85 653 707561 52321 41860800
Subcutaneous haematoma 32.21 12.85 62 708152 1033 41912088
Ankylosing spondylitis 32.13 12.85 42 708172 7014 41906107
Hyphaema 32.05 12.85 49 708165 671 41912450
Psychiatric decompensation 32.02 12.85 15 708199 4207 41908914
Hyperaesthesia 31.94 12.85 31 708183 5921 41907200
Oesophageal carcinoma 31.94 12.85 71 708143 9625 41903496
Renal haemorrhage 31.94 12.85 78 708136 1541 41911580
Intracardiac thrombus 31.93 12.85 101 708113 2331 41910790
Puncture site haemorrhage 31.85 12.85 34 708180 316 41912805
Pneumonia aspiration 31.81 12.85 613 707601 49465 41863656
Cholestasis 31.77 12.85 371 707843 32508 41880613
Blood creatine phosphokinase MB increased 31.76 12.85 88 708126 1882 41911239
Hallucination, auditory 31.67 12.85 133 708081 14731 41898390
Apparent death 31.66 12.85 11 708203 3697 41909424
Electrocardiogram T wave inversion 31.63 12.85 98 708116 2236 41910885
Arteriovenous malformation 31.54 12.85 53 708161 790 41912331
Total lung capacity decreased 31.52 12.85 10 708204 3560 41909561
Colonic haematoma 31.51 12.85 14 708200 20 41913101
Kounis syndrome 31.42 12.85 125 708089 3243 41909878
Coagulation time abnormal 31.41 12.85 21 708193 93 41913028
Transaminases increased 31.41 12.85 372 707842 32513 41880608
Bleeding time prolonged 31.40 12.85 47 708167 631 41912490
Gastrointestinal angiodysplasia 31.40 12.85 47 708167 631 41912490
Vertigo 31.36 12.85 770 707444 33577 41879544
Injection site swelling 31.35 12.85 160 708054 16813 41896308
Diffuse large B-cell lymphoma 31.33 12.85 69 708145 9385 41903736
Lymphadenopathy 31.27 12.85 379 707835 32986 41880135
Alanine aminotransferase increased 31.22 12.85 1177 707037 87229 41825892
Alanine aminotransferase abnormal 31.17 12.85 22 708192 4922 41908199
Acute kidney injury 31.16 12.85 6728 701486 360609 41552512
Stenosis 31.10 12.85 91 708123 2010 41911111
Coronary artery dissection 31.09 12.85 32 708182 284 41912837
Chronic obstructive pulmonary disease 31.08 12.85 1314 706900 61800 41851321
Palmar-plantar erythrodysaesthesia syndrome 31.08 12.85 207 708007 20375 41892746
Aspartate aminotransferase increased 30.76 12.85 1012 707202 76151 41836970
Hypoalbuminaemia 30.65 12.85 144 708070 15466 41897655
Electrocardiogram Q wave abnormal 30.63 12.85 41 708173 493 41912628
Respiratory failure 30.41 12.85 1780 706434 126352 41786769
Scrotal haematoma 30.41 12.85 19 708195 73 41913048
Abdominal pain upper 30.36 12.85 1671 706543 80938 41832183
Cataract 30.35 12.85 694 707520 29910 41883211
Haemorrhoidal haemorrhage 30.31 12.85 144 708070 4044 41909077
Aortic valve stenosis 30.30 12.85 115 708099 2917 41910204
Arrhythmia 30.26 12.85 881 707333 39436 41873685
Sleep terror 30.07 12.85 6 708208 2920 41910201
Prostate cancer stage I 30.00 12.85 4 708210 2617 41910504
Cardiac ventricular thrombosis 29.98 12.85 82 708132 1740 41911381
Paradoxical drug reaction 29.98 12.85 21 708193 4717 41908404
Ischaemia 29.86 12.85 164 708050 4883 41908238
Hepatic function abnormal 29.85 12.85 641 707573 50926 41862195
Arterial stenosis 29.82 12.85 63 708151 1126 41911995
Anxiety 29.78 12.85 1638 706576 116922 41796199
Developmental delay 29.77 12.85 8 708206 3174 41909947
Osteonecrosis 29.62 12.85 149 708065 15716 41897405
Aspiration 29.53 12.85 175 708039 17711 41895410
Venous pressure jugular increased 29.50 12.85 49 708165 723 41912398
Pharyngeal haemorrhage 29.35 12.85 50 708164 754 41912367
Tachycardia 29.34 12.85 1376 706838 99711 41813410
Meningitis cryptococcal 29.34 12.85 9 708205 3274 41909847
Pneumonia fungal 29.29 12.85 68 708146 9078 41904043
Blood urea increased 29.29 12.85 733 707481 32060 41881061
Pulmonary tuberculosis 29.12 12.85 29 708185 5472 41907649
Clostridium difficile colitis 29.04 12.85 220 707994 21032 41892089
Circulatory collapse 29.00 12.85 553 707661 23083 41890038
Drug level decreased 28.98 12.85 78 708136 9899 41903222
Atrioventricular block 28.87 12.85 265 707949 9350 41903771
Mania 28.76 12.85 85 708129 10462 41902659
Precancerous skin lesion 28.74 12.85 43 708171 577 41912544
Platelet dysfunction 28.73 12.85 31 708183 292 41912829
Device issue 28.71 12.85 121 708093 13388 41899733
Subcapsular renal haematoma 28.55 12.85 41 708173 529 41912592
Hyperthermia malignant 28.28 12.85 5 708209 2653 41910468
Nephropathy toxic 28.19 12.85 164 708050 16674 41896447
Cardiovascular disorder 28.19 12.85 343 707871 13022 41900099
Exercise tolerance decreased 28.14 12.85 185 708029 5881 41907240
Unintentional medical device removal 28.06 12.85 9 708205 3182 41909939
Pulmonary haematoma 28.05 12.85 17 708197 61 41913060
Juvenile idiopathic arthritis 28.00 12.85 5 708209 2634 41910487
Haemorrhage coronary artery 27.89 12.85 12 708202 15 41913106
Tongue oedema 27.85 12.85 119 708095 3191 41909930
Carotid bruit 27.82 12.85 23 708191 149 41912972
Platelet function test abnormal 27.81 12.85 20 708194 102 41913019
Extrasystoles 27.80 12.85 141 708073 4068 41909053
Tooth disorder 27.74 12.85 313 707901 11666 41901455
Arterial spasm 27.74 12.85 18 708196 75 41913046
Fistula 27.68 12.85 56 708158 7856 41905265
Staphylococcal infection 27.66 12.85 449 707765 37194 41875927
Hepatic encephalopathy 27.61 12.85 160 708054 16282 41896839
Aortic aneurysm rupture 27.58 12.85 59 708155 1064 41912057
Blood potassium increased 27.50 12.85 447 707767 18089 41895032
Abdominal pain 27.48 12.85 2758 705456 187713 41725408
Atrioventricular block second degree 27.47 12.85 140 708074 4047 41909074
Aortic intramural haematoma 27.38 12.85 15 708199 42 41913079
Lipoprotein (a) increased 27.36 12.85 32 708182 332 41912789
Myocarditis 27.34 12.85 193 708021 18745 41894376
Gait disturbance 27.27 12.85 1935 706279 96065 41817056
Uveitis 27.18 12.85 72 708142 9186 41903935
Growth retardation 27.16 12.85 4 708210 2428 41910693
Salivary hypersecretion 27.16 12.85 92 708122 10851 41902270
Neurological symptom 26.89 12.85 81 708133 9910 41903211
Malignant melanoma in situ 26.87 12.85 104 708110 2663 41910458
Nocardiosis 26.74 12.85 28 708186 5162 41907959
Non-cardiac chest pain 26.68 12.85 147 708067 4382 41908739
Affective disorder 26.61 12.85 36 708178 5924 41907197
Polycythaemia vera 26.56 12.85 34 708180 390 41912731
Brain natriuretic peptide increased 26.44 12.85 198 708016 6572 41906549
Drug specific antibody present 26.36 12.85 17 708197 3989 41909132
Lower respiratory tract infection 26.29 12.85 504 707710 40702 41872419
Diabetic foot 26.26 12.85 111 708103 2962 41910159
Device interaction 26.26 12.85 40 708174 546 41912575
Labelled drug-disease interaction medication error 26.25 12.85 21 708193 129 41912992
Injection site erythema 26.22 12.85 212 708002 19983 41893138
Bundle branch block right 26.18 12.85 227 707987 7879 41905242
Brain stem infarction 26.15 12.85 64 708150 1266 41911855
Arteriosclerosis coronary artery 26.09 12.85 446 707768 18231 41894890
Intestinal diaphragm disease 26.04 12.85 29 708185 284 41912837
Erosive duodenitis 26.01 12.85 77 708137 1712 41911409
Vertebral artery stenosis 26.00 12.85 21 708193 131 41912990
Hypercholesterolaemia 25.92 12.85 327 707887 12522 41900599
Helicobacter test positive 25.90 12.85 48 708166 776 41912345
Mydriasis 25.90 12.85 68 708146 8702 41904419
Herpes simplex 25.88 12.85 49 708165 7046 41906075
Respiratory tract haemorrhage 25.82 12.85 66 708148 1343 41911778
Metastases to central nervous system 25.74 12.85 87 708127 10268 41902853
Haemothorax 25.71 12.85 162 708052 5074 41908047
Tuberculosis 25.69 12.85 84 708130 10015 41903106
Hyperammonaemic encephalopathy 25.68 12.85 7 708207 2751 41910370
Orthopnoea 25.62 12.85 166 708048 5251 41907870
Diffuse large B-cell lymphoma recurrent 25.59 12.85 26 708188 4860 41908261
Mouth haemorrhage 25.53 12.85 185 708029 6076 41907045
Needle issue 25.52 12.85 68 708146 8659 41904462
JC virus infection 25.50 12.85 9 708205 2995 41910126
Page kidney 25.43 12.85 13 708201 30 41913091
Catheter site haematoma 25.32 12.85 23 708191 172 41912949
Conjunctival haemorrhage 25.22 12.85 121 708093 3412 41909709
Colitis microscopic 25.11 12.85 111 708103 3022 41910099
Hypertensive heart disease 25.08 12.85 97 708117 2483 41910638
Exposure via skin contact 25.05 12.85 28 708186 5010 41908111
Dementia 25.04 12.85 399 707815 16081 41897040
Lipodystrophy acquired 25.04 12.85 13 708201 3437 41909684
Gastrointestinal disorder 24.98 12.85 587 707627 46066 41867055
Traumatic haematoma 24.98 12.85 46 708168 740 41912381
Choroidal haemorrhage 24.85 12.85 18 708196 93 41913028
Encephalitis 24.83 12.85 74 708140 9084 41904037
Device use error 24.80 12.85 11 708203 3186 41909935
Dehydration 24.80 12.85 2705 705509 139062 41774059
Amyloid related imaging abnormality-oedema/effusion 24.77 12.85 43 708171 659 41912462
Cerebral ischaemia 24.67 12.85 199 708015 6760 41906361
Cerebral artery stenosis 24.51 12.85 31 708183 351 41912770
Prostate cancer stage IV 24.50 12.85 6 708208 2534 41910587
Brain stem haemorrhage 24.41 12.85 53 708161 966 41912155
Histoplasmosis disseminated 24.40 12.85 3 708211 2088 41911033
Dyspepsia 24.38 12.85 878 707336 40474 41872647
Atrioventricular block first degree 24.32 12.85 188 708026 6303 41906818
Erosive oesophagitis 24.30 12.85 68 708146 1463 41911658
Wound haemorrhage 24.21 12.85 89 708125 2222 41910899
Incision site haemorrhage 24.19 12.85 37 708177 507 41912614
Thrombotic stroke 23.93 12.85 26 708188 247 41912874
Eczema 23.93 12.85 410 707804 33676 41879445
Intra-abdominal haematoma 23.90 12.85 69 708145 1512 41911609
Pallor 23.85 12.85 639 707575 28247 41884874
Dilatation atrial 23.84 12.85 85 708129 2090 41911031
Basal ganglia infarction 23.83 12.85 24 708190 207 41912914
Myelodysplastic syndrome 23.81 12.85 252 707962 22493 41890628
End stage renal disease 23.78 12.85 169 708045 16389 41896732
Diverticulum intestinal 23.76 12.85 156 708058 4957 41908164
Carotid arteriosclerosis 23.76 12.85 89 708125 2243 41910878
Pneumonitis 23.73 12.85 520 707694 41198 41871923
Periorbital haemorrhage 23.71 12.85 19 708195 117 41913004
Bone erosion 23.55 12.85 23 708191 4380 41908741
Aortic bypass 23.53 12.85 9 708205 6 41913115
Hypothyroidism 23.47 12.85 383 707831 31701 41881420
Basilar artery stenosis 23.46 12.85 10 708204 12 41913109
Antipsychotic drug level below therapeutic 23.36 12.85 12 708202 3192 41909929
Strongyloidiasis 23.35 12.85 14 708200 3417 41909704
Inspiratory capacity decreased 23.35 12.85 10 708204 2957 41910164
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits 23.34 12.85 42 708172 663 41912458
Cerebral ventricular rupture 23.22 12.85 23 708191 194 41912927
Peripheral artery occlusion 23.22 12.85 75 708139 1751 41911370
Disseminated intravascular coagulation 23.10 12.85 282 707932 24512 41888609
Illness 23.05 12.85 284 707930 24646 41888475
Retinal artery occlusion 22.95 12.85 85 708129 2130 41910991
Aneurysm 22.93 12.85 82 708132 2019 41911102
Aphasia 22.92 12.85 543 707671 23540 41889581
Haemoperitoneum 22.87 12.85 81 708133 1985 41911136
Gastrointestinal polyp haemorrhage 22.86 12.85 35 708179 480 41912641
Coronary artery insufficiency 22.85 12.85 15 708199 64 41913057
Metastases to liver 22.78 12.85 168 708046 16158 41896963
Cardiac valve disease 22.71 12.85 115 708099 3316 41909805
Haematoma muscle 22.69 12.85 83 708131 2067 41911054
Small intestine ulcer 22.69 12.85 36 708178 510 41912611
Blood pressure diastolic abnormal 22.63 12.85 42 708172 6086 41907035
Fungaemia 22.49 12.85 12 708202 3124 41909997
Coronary ostial stenosis 22.47 12.85 17 708197 95 41913026
Vascular device infection 22.46 12.85 42 708172 6068 41907053
Silent myocardial infarction 22.45 12.85 30 708184 360 41912761
Human herpesvirus 6 infection 22.42 12.85 7 708207 2518 41910603
Diverticulum oesophageal 22.41 12.85 8 708206 3 41913118
Orthostatic intolerance 22.39 12.85 47 708167 836 41912285
Epigastric discomfort 22.38 12.85 93 708121 2462 41910659
Incision site haematoma 22.33 12.85 17 708197 96 41913025
Benign prostatic hyperplasia 22.33 12.85 482 707732 20570 41892551
Hyperlipidaemia 22.30 12.85 491 707723 21025 41892096
Migraine 22.20 12.85 293 707921 25121 41888000
Blood uric acid increased 22.17 12.85 159 708055 15388 41897733
Second primary malignancy 22.10 12.85 83 708131 9492 41903629
Leukoencephalopathy 22.04 12.85 30 708184 4924 41908197
Essential hypertension 22.00 12.85 122 708092 3646 41909475
Subclavian artery stenosis 21.99 12.85 14 708200 56 41913065
Aortic valve sclerosis 21.98 12.85 54 708160 1071 41912050
Pneumocystis jirovecii infection 21.94 12.85 10 708204 2850 41910271
Abdominal distension 21.92 12.85 971 707243 70764 41842357
Supraventricular tachycardia 21.81 12.85 308 707906 12100 41901021
Flap necrosis 21.80 12.85 7 708207 0 41913121
Reye's syndrome 21.80 12.85 7 708207 0 41913121
Infarction 21.71 12.85 104 708110 2931 41910190
Arteriospasm coronary 21.68 12.85 144 708070 4594 41908527
Anal abscess 21.59 12.85 63 708151 7787 41905334
International normalised ratio decreased 21.56 12.85 140 708074 4432 41908689
Asthma 21.47 12.85 832 707382 61482 41851639
Atrial thrombosis 21.44 12.85 89 708125 2355 41910766
Haemorrhoids 21.31 12.85 401 707813 16696 41896425
Social avoidant behaviour 21.17 12.85 15 708199 3349 41909772
Faeces pale 21.16 12.85 67 708147 1547 41911574
Eosinophil count decreased 21.15 12.85 17 708197 3559 41909562
Drug level increased 21.13 12.85 307 707907 25893 41887228
Dust allergy 21.09 12.85 35 708179 5297 41907824
Cold sweat 21.03 12.85 284 707930 11046 41902075
Small intestine polyp 21.02 12.85 9 708205 11 41913110
Antipsychotic drug level increased 21.02 12.85 28 708186 4638 41908483
Microcytic anaemia 20.99 12.85 103 708111 2932 41910189
Cerebral mass effect 20.93 12.85 59 708155 1275 41911846
Bacterial sepsis 20.92 12.85 48 708166 6434 41906687
Compartment syndrome 20.90 12.85 109 708105 3180 41909941
Catheterisation cardiac 20.90 12.85 97 708117 2697 41910424
Product dose omission in error 20.89 12.85 70 708144 8284 41904837
Chronic gastritis 20.87 12.85 82 708132 2115 41911006
Angiopathy 20.85 12.85 157 708057 5220 41907901
Viral haemorrhagic cystitis 20.82 12.85 3 708211 1851 41911270
Viral load increased 20.72 12.85 12 708202 2985 41910136
Immune-mediated hepatic disorder 20.55 12.85 8 708206 2506 41910615
Hyperprolactinaemia 20.51 12.85 5 708209 2118 41911003
Exposure via ingestion 20.49 12.85 5 708209 2117 41911004
Deep vein thrombosis 20.46 12.85 1514 706700 75443 41837678
Glycosylated haemoglobin increased 20.43 12.85 315 707899 12609 41900512
Polyomavirus viraemia 20.35 12.85 5 708209 2107 41911014
Craniocerebral injury 20.33 12.85 121 708093 3713 41909408
Alopecia 20.27 12.85 353 707861 28923 41884198
Diabetes mellitus inadequate control 20.24 12.85 364 707850 15026 41898095
Pharyngitis streptococcal 20.14 12.85 21 708193 3879 41909242
Vessel puncture site haemorrhage 20.13 12.85 14 708200 67 41913054
Carotid artery occlusion 20.13 12.85 129 708085 4065 41909056
Anal inflammation 20.12 12.85 6 708208 2223 41910898
Depression 20.07 12.85 1585 706629 109778 41803343
Cardiac valve replacement complication 20.03 12.85 11 708203 31 41913090
Spontaneous haematoma 19.99 12.85 41 708173 717 41912404
Neutropenic colitis 19.96 12.85 27 708187 4443 41908678
Neoplasm malignant 19.95 12.85 262 707952 22481 41890640
Prostatic adenoma 19.90 12.85 20 708194 172 41912949
Cerebellar infarction 19.90 12.85 81 708133 2124 41910997
Splenic injury 19.87 12.85 10 708204 22 41913099
Oesophageal ulcer haemorrhage 19.85 12.85 28 708186 355 41912766
Oropharyngeal pain 19.78 12.85 546 707668 41964 41871157
Computerised tomogram coronary artery abnormal 19.77 12.85 18 708196 135 41912986
Muscle injury 19.76 12.85 67 708147 1605 41911516
Echocardiogram abnormal 19.76 12.85 56 708158 1214 41911907
Oral candidiasis 19.74 12.85 149 708065 14256 41898865
Granulocytopenia 19.64 12.85 57 708157 7057 41906064
Dizziness postural 19.58 12.85 207 708007 7588 41905533
Diverticulitis intestinal haemorrhagic 19.56 12.85 27 708187 335 41912786
Blindness transient 19.54 12.85 95 708119 2694 41910427
Headache 19.52 12.85 3591 704623 235778 41677343
Anaphylactic shock 19.51 12.85 274 707940 23243 41889878
Thrombotic thrombocytopenic purpura 19.50 12.85 119 708095 3685 41909436
Cardiac stress test abnormal 19.50 12.85 27 708187 336 41912785
Blood pressure systolic abnormal 19.45 12.85 39 708175 5489 41907632
Oesophagitis haemorrhagic 19.41 12.85 22 708192 220 41912901
Blue toe syndrome 19.38 12.85 18 708196 139 41912982
Tenosynovitis 19.35 12.85 30 708184 4665 41908456
Gallbladder disorder 19.33 12.85 196 708018 7106 41906015
Pharyngeal haematoma 19.23 12.85 14 708200 73 41913048
Foetal exposure timing unspecified 19.22 12.85 24 708190 268 41912853
Post procedural complication 19.20 12.85 305 707909 12285 41900836
Spinal cord haematoma 19.20 12.85 16 708198 105 41913016
Liver function test increased 19.18 12.85 226 707988 19772 41893349
Degenerative mitral valve disease 19.16 12.85 24 708190 269 41912852
Weight increased 19.14 12.85 1539 706675 106444 41806677
Drug level below therapeutic 19.14 12.85 51 708163 6494 41906627
Coronary artery reocclusion 19.09 12.85 14 708200 74 41913047
Brain contusion 18.92 12.85 47 708167 939 41912182
Pollakiuria 18.91 12.85 499 707715 22006 41891115
Cerebral microhaemorrhage 18.89 12.85 20 708194 184 41912937
Hypomania 18.88 12.85 9 708205 2499 41910622
Systemic mycosis 18.86 12.85 8 708206 2379 41910742
Wound 18.83 12.85 394 707820 16723 41896398
Blood pressure fluctuation 18.77 12.85 324 707890 26584 41886537
Platelet aggregation test 18.76 12.85 10 708204 26 41913095
Mitochondrial toxicity 18.76 12.85 10 708204 2605 41910516
Abscess 18.76 12.85 149 708065 14099 41899022
Catatonia 18.71 12.85 48 708166 6191 41906930
Delusion of grandeur 18.71 12.85 5 708209 1991 41911130
Type V hyperlipidaemia 18.67 12.85 46 708168 914 41912207
Tendon rupture 18.62 12.85 211 708003 7872 41905249
Persecutory delusion 18.62 12.85 19 708195 3545 41909576
Limb discomfort 18.61 12.85 307 707907 12460 41900661
Hypovolaemic shock 18.60 12.85 223 707991 8436 41904685
Atheroembolism 18.58 12.85 26 708188 327 41912794
Rhythm idioventricular 18.58 12.85 26 708188 327 41912794
Mouth ulceration 18.55 12.85 159 708055 14804 41898317
Gastrointestinal tract mucosal pigmentation 18.54 12.85 34 708180 545 41912576
Alcohol abuse 18.54 12.85 24 708190 4025 41909096
Blood lactate dehydrogenase increased 18.53 12.85 313 707901 25768 41887353
Urogenital haemorrhage 18.53 12.85 39 708175 695 41912426
Stent-graft endoleak 18.51 12.85 10 708204 27 41913094
Gastric ulcer perforation 18.48 12.85 49 708165 1020 41912101
Pericardial disease 18.45 12.85 32 708182 490 41912631
Gastroduodenal haemorrhage 18.43 12.85 19 708195 169 41912952
Systolic dysfunction 18.32 12.85 99 708115 2929 41910192
Intestinal obstruction 18.31 12.85 329 707885 26829 41886292
Splenic haemorrhage 18.29 12.85 33 708181 522 41912599
Electrocardiogram PR prolongation 18.24 12.85 47 708167 961 41912160
Ear infection 18.23 12.85 131 708083 12673 41900448
Blood pressure inadequately controlled 18.20 12.85 95 708119 2773 41910348
Palpitations 18.16 12.85 1025 707189 49772 41863349
Facial bones fracture 18.15 12.85 83 708131 2293 41910828
Arterial intramural haematoma 18.14 12.85 12 708202 52 41913069
Clostridium difficile infection 18.10 12.85 266 707948 22393 41890728
Dermatitis exfoliative generalised 18.10 12.85 44 708170 5780 41907341
Oxygen saturation decreased 18.08 12.85 884 707330 63803 41849318
Drug level above therapeutic 18.05 12.85 45 708169 5861 41907260
Ocular retrobulbar haemorrhage 18.05 12.85 11 708203 40 41913081
Acute myeloid leukaemia recurrent 18.04 12.85 19 708195 3493 41909628
Finger amputation 18.02 12.85 21 708193 217 41912904
Brain abscess 18.01 12.85 27 708187 4257 41908864
Actinic elastosis 17.98 12.85 12 708202 53 41913068
Dermatitis acneiform 17.92 12.85 67 708147 7672 41905449
Blood pressure diastolic increased 17.91 12.85 51 708163 6354 41906767
Hepatotoxicity 17.90 12.85 302 707912 24865 41888256
Renal cancer 17.89 12.85 73 708141 8151 41904970
Asbestosis 17.87 12.85 21 708193 219 41912902
Crying 17.82 12.85 51 708163 6343 41906778
Inferior vena cava dilatation 17.79 12.85 41 708173 779 41912342
Maternal exposure during pregnancy 17.78 12.85 58 708156 6920 41906201
Ruptured cerebral aneurysm 17.77 12.85 19 708195 177 41912944
Barrett's oesophagus 17.75 12.85 27 708187 368 41912753
Prostate cancer stage III 17.75 12.85 4 708210 1788 41911333
Implant site haematoma 17.71 12.85 15 708199 101 41913020
Blood prolactin increased 17.68 12.85 8 708206 2290 41910831
Myocardial necrosis marker increased 17.68 12.85 70 708144 1812 41911309
Anal fissure 17.56 12.85 38 708176 5201 41907920
Labelled drug-drug interaction issue 17.55 12.85 67 708147 1704 41911417
Device embolisation 17.55 12.85 10 708204 31 41913090
SARS-CoV-2 test negative 17.50 12.85 4 708210 1771 41911350
Thalamic infarction 17.50 12.85 41 708173 788 41912333
Myocardial haemorrhage 17.47 12.85 11 708203 43 41913078
Mitral valve disease 17.40 12.85 60 708154 1450 41911671
Brain stem stroke 17.33 12.85 25 708189 324 41912797
Prostate cancer stage II 17.31 12.85 8 708206 2262 41910859
Bronchial haemorrhage 17.30 12.85 37 708177 667 41912454
Ill-defined disorder 17.28 12.85 180 708034 16116 41897005
Shone complex 17.27 12.85 13 708201 72 41913049
Tic 17.26 12.85 9 708205 2374 41910747
Hypertension 17.25 12.85 3093 705121 164111 41749010
Varicella zoster virus infection 17.17 12.85 11 708203 2590 41910531
Hernia 17.17 12.85 269 707945 10804 41902317
Hepatosplenomegaly 17.16 12.85 32 708182 4628 41908493
Acute hepatic failure 17.14 12.85 191 708023 16882 41896239
Pharyngeal oedema 17.10 12.85 165 708049 5903 41907218
Chronic coronary syndrome 17.09 12.85 23 708191 278 41912843
Naevus flammeus 17.06 12.85 19 708195 186 41912935
Vitamin B12 deficiency 17.04 12.85 140 708074 4782 41908339
Infective exacerbation of chronic obstructive airways disease 17.03 12.85 73 708141 1960 41911161
Clonus 17.03 12.85 20 708194 3500 41909621
Coronary artery embolism 17.02 12.85 17 708197 145 41912976
Duodenitis haemorrhagic 17.02 12.85 14 708200 90 41913031
Neutropenic sepsis 16.97 12.85 176 708038 15770 41897351
Tooth socket haemorrhage 16.92 12.85 11 708203 46 41913075
Implant site haemorrhage 16.90 12.85 14 708200 91 41913030
Lymphoproliferative disorder 16.86 12.85 18 708196 3289 41909832
Altered state of consciousness 16.84 12.85 364 707850 28895 41884226
Type 2 diabetes mellitus 16.83 12.85 414 707800 18057 41895064
Prostatic disorder 16.81 12.85 112 708102 3577 41909544
Haemarthrosis 16.80 12.85 119 708095 3879 41909242
Staphylococcal bacteraemia 16.71 12.85 112 708102 11009 41902112
Metastases to lung 16.70 12.85 116 708098 11308 41901813
Tardive dyskinesia 16.65 12.85 59 708155 6865 41906256
Putamen haemorrhage 16.65 12.85 22 708192 261 41912860
Implantable defibrillator insertion 16.64 12.85 40 708174 782 41912339
Urine flow decreased 16.62 12.85 56 708158 1337 41911784
Skin flap necrosis 16.60 12.85 7 708207 8 41913113
Cerebral small vessel ischaemic disease 16.59 12.85 32 708182 534 41912587
Diabetic nephropathy 16.59 12.85 80 708134 2261 41910860
Arterial stent insertion 16.56 12.85 14 708200 94 41913027
Medical device site thrombosis 16.48 12.85 9 708205 25 41913096
Thrombolysis 16.44 12.85 14 708200 95 41913026
Scedosporium infection 16.42 12.85 3 708211 1555 41911566
Periorbital oedema 16.42 12.85 133 708081 4524 41908597
Philadelphia positive acute lymphocytic leukaemia 16.41 12.85 11 708203 49 41913072
Maternal exposure during breast feeding 16.38 12.85 3 708211 1552 41911569
Arterial disorder 16.37 12.85 53 708161 1239 41911882
Reversible airways obstruction 16.36 12.85 33 708181 570 41912551
Retinal haemorrhage 16.31 12.85 157 708057 5613 41907508
Cerebral arteriosclerosis 16.27 12.85 32 708182 542 41912579
Myxoedema coma 16.27 12.85 21 708193 243 41912878
Haemorrhagic ascites 16.25 12.85 17 708197 154 41912967
Cardiotoxicity 16.25 12.85 66 708148 7379 41905742
Hypertriglyceridaemia 16.23 12.85 100 708114 10026 41903095
Vascular occlusion 16.16 12.85 44 708170 931 41912190
Cardiac discomfort 16.16 12.85 37 708177 700 41912421
Accidental overdose 16.14 12.85 353 707861 27977 41885144
Graft thrombosis 16.11 12.85 22 708192 270 41912851
Mental disorder 16.07 12.85 207 708007 17822 41895299
Cystic fibrosis 16.05 12.85 7 708207 2048 41911073
Fractional exhaled nitric oxide increased 16.05 12.85 61 708153 1548 41911573
Intestinal haematoma 16.04 12.85 19 708195 200 41912921
Prescribed underdose 16.02 12.85 250 707964 10032 41903089
Disturbance in social behaviour 16.01 12.85 5 708209 1798 41911323
Carcinoma in situ of skin 15.99 12.85 13 708201 82 41913039
Peripheral artery aneurysm 15.96 12.85 31 708183 520 41912601
Kidney transplant rejection 15.95 12.85 82 708132 8601 41904520
Metastases to bone 15.94 12.85 163 708051 14646 41898475
Psychotic symptom 15.92 12.85 10 708204 2380 41910741
Hemiataxia 15.90 12.85 10 708204 39 41913082
Helicobacter infection 15.89 12.85 86 708128 2546 41910575
Acute generalised exanthematous pustulosis 15.88 12.85 81 708133 8514 41904607
Laboratory test abnormal 15.86 12.85 497 707717 22481 41890640
Vertigo positional 15.85 12.85 44 708170 942 41912179
Hepatocellular carcinoma 15.85 12.85 76 708138 8118 41905003
Prostate cancer 15.83 12.85 594 707620 44049 41869072
Priapism 15.81 12.85 54 708160 6353 41906768
Platelet aggregation inhibition 15.78 12.85 8 708206 18 41913103
Extraocular muscle disorder 15.78 12.85 20 708194 227 41912894
Anti-cyclic citrullinated peptide antibody positive 15.77 12.85 6 708208 1906 41911215
Tearfulness 15.77 12.85 21 708193 3479 41909642
Intestinal stenosis 15.76 12.85 14 708200 2790 41910331
Vertebrobasilar insufficiency 15.75 12.85 15 708199 120 41913001
Supravalvular aortic stenosis 15.71 12.85 10 708204 40 41913081
Prinzmetal angina 15.71 12.85 54 708160 1303 41911818
Intestinal haemorrhage 15.68 12.85 116 708098 3835 41909286
Prostatic haemorrhage 15.66 12.85 21 708193 253 41912868
Cerebral aspergillosis 15.65 12.85 5 708209 1772 41911349
Anaemia macrocytic 15.64 12.85 107 708107 3448 41909673
Wrong patient received product 15.64 12.85 22 708192 3561 41909560
Palmoplantar keratoderma 15.62 12.85 9 708205 2245 41910876
Hyponatraemia 15.61 12.85 1462 706752 100000 41813121
Vessel puncture site haematoma 15.60 12.85 12 708202 69 41913052
Faecal calprotectin increased 15.60 12.85 17 708197 3077 41910044
Dilatation ventricular 15.60 12.85 84 708130 2482 41910639
Bleeding time abnormal 15.57 12.85 5 708209 0 41913121
Presbyoesophagus 15.57 12.85 5 708209 0 41913121
Dysgeusia 15.54 12.85 706 707508 33483 41879638
Ileus 15.52 12.85 224 707990 18915 41894206
Depressive symptom 15.52 12.85 25 708189 3828 41909293
Spinal cord haemorrhage 15.51 12.85 23 708191 306 41912815
Frequent bowel movements 15.51 12.85 256 707958 21151 41891970
Factor V deficiency 15.50 12.85 8 708206 19 41913102
Pneumatosis intestinalis 15.49 12.85 35 708179 4717 41908404
Hypoparathyroidism secondary 15.44 12.85 18 708196 186 41912935
Amputation 15.39 12.85 39 708175 789 41912332
Vascular procedure complication 15.37 12.85 7 708207 11 41913110
Hypotonia neonatal 15.34 12.85 3 708211 1481 41911640
Dyspnoea at rest 15.33 12.85 122 708092 4127 41908994
Genitourinary tract infection 15.28 12.85 14 708200 106 41913015
Oesophageal haemorrhage 15.28 12.85 55 708159 1359 41911762
Ocular icterus 15.26 12.85 96 708118 3005 41910116
Hepatitis C 15.25 12.85 102 708112 10031 41903090
Fusarium infection 15.24 12.85 4 708210 1612 41911509
Endoscopy upper gastrointestinal tract 15.18 12.85 10 708204 43 41913078
Anaemia of malignant disease 15.14 12.85 30 708184 511 41912610
Mitral valve thickening 15.14 12.85 28 708186 452 41912669
Haematocoele 15.13 12.85 6 708208 5 41913116
Intestinal perforation 15.12 12.85 112 708102 10762 41902359
Liver abscess 15.09 12.85 38 708176 4932 41908189
Carcinogenicity 15.09 12.85 12 708202 73 41913048
Arterial thrombosis 15.06 12.85 64 708150 1712 41911409
Platelet aggregation increased 15.01 12.85 7 708207 12 41913109
Musculoskeletal discomfort 15.00 12.85 231 707983 9245 41903876
Tongue disorder 14.95 12.85 43 708171 5340 41907781
Bladder neoplasm 14.93 12.85 57 708157 1450 41911671
Hyperreflexia 14.91 12.85 23 708191 3584 41909537
Pain in extremity 14.90 12.85 2780 705434 147824 41765297
Mitral valve calcification 14.90 12.85 33 708181 610 41912511
Blood calcium increased 14.88 12.85 81 708133 8373 41904748
Creatinine renal clearance decreased 14.87 12.85 107 708107 3506 41909615
Renal cyst 14.86 12.85 242 707972 9797 41903324
Immune-mediated myositis 14.85 12.85 111 708103 3682 41909439
Groin pain 14.82 12.85 161 708053 5943 41907178
Pneumomediastinum 14.76 12.85 18 708196 3098 41910023
Lip oedema 14.71 12.85 97 708117 3087 41910034
Hypoaesthesia 14.71 12.85 1379 706835 70084 41843037
Hyperleukocytosis 14.68 12.85 13 708201 2595 41910526
Complications of transplanted kidney 14.67 12.85 43 708171 5307 41907814
Macular degeneration 14.65 12.85 82 708132 2459 41910662
Urethral haemorrhage 14.64 12.85 29 708185 494 41912627
Vascular access site haematoma 14.63 12.85 6 708208 6 41913115
Immune-mediated enterocolitis 14.59 12.85 47 708167 5630 41907491
Laryngeal haematoma 14.49 12.85 16 708198 155 41912966
Drop attacks 14.46 12.85 31 708183 560 41912561
Differentiation syndrome 14.44 12.85 6 708208 1807 41911314
Patellofemoral pain syndrome 14.41 12.85 15 708199 135 41912986
Device malfunction 14.40 12.85 133 708081 12194 41900927
Dysarthria 14.38 12.85 804 707410 39003 41874118
Cardiac death 14.36 12.85 47 708167 1105 41912016
Disseminated cryptococcosis 14.35 12.85 7 708207 1918 41911203
Toxic anterior segment syndrome 14.35 12.85 3 708211 1413 41911708
Sensation of foreign body 14.30 12.85 106 708108 3507 41909614
Enteritis 14.29 12.85 113 708101 10703 41902418
Low density lipoprotein abnormal 14.27 12.85 25 708189 386 41912735
Epidural lipomatosis 14.27 12.85 6 708208 1794 41911327
Increased appetite 14.25 12.85 88 708126 8818 41904303
Blood pressure systolic decreased 14.25 12.85 136 708078 4851 41908270
Colitis ischaemic 14.19 12.85 183 708031 7043 41906078
Poor venous access 14.18 12.85 67 708147 7185 41905936
Eye injury 14.14 12.85 43 708171 971 41912150
Lactose intolerance 14.13 12.85 56 708158 1450 41911671
Autoimmune myocarditis 14.10 12.85 20 708194 255 41912866
Vascular graft complication 14.09 12.85 15 708199 139 41912982
Disturbance in attention 14.05 12.85 383 707831 29483 41883638
Thromboangiitis obliterans 14.03 12.85 7 708207 15 41913106
Steroid diabetes 14.02 12.85 16 708198 2836 41910285
Myoglobin blood increased 13.99 12.85 107 708107 3575 41909546
Large intestinal ulcer haemorrhage 13.97 12.85 14 708200 120 41913001
Coronary artery surgery 13.97 12.85 14 708200 120 41913001
Enterocolitis 13.94 12.85 102 708112 9827 41903294
Arteriovenous fistula site haemorrhage 13.93 12.85 13 708201 101 41913020
Lymph node calcification 13.93 12.85 15 708199 141 41912980
Pneumonia klebsiella 13.90 12.85 31 708183 4198 41908923
Myopathy toxic 13.88 12.85 35 708179 706 41912415
Affect lability 13.83 12.85 29 708185 4015 41909106
Transplant failure 13.83 12.85 29 708185 4015 41909106
Blood parathyroid hormone decreased 13.81 12.85 5 708209 1638 41911483
Cerebral hyperperfusion syndrome 13.81 12.85 12 708202 84 41913037
Gastric mucosal lesion 13.79 12.85 34 708180 676 41912445
Aortic valve disease 13.78 12.85 52 708162 1315 41911806
Musculoskeletal pain 13.78 12.85 682 707532 32658 41880463
Choroidal dystrophy 13.77 12.85 8 708206 26 41913095
Prescription drug used without a prescription 13.76 12.85 15 708199 2715 41910406
Rectal ulcer 13.74 12.85 47 708167 1131 41911990
Abdominal strangulated hernia 13.73 12.85 6 708208 8 41913113
Necrotising myositis 13.73 12.85 46 708168 1095 41912026
Cardiac murmur 13.71 12.85 293 707921 12482 41900639
Large intestinal polypectomy 13.70 12.85 12 708202 85 41913036
Heart valve stenosis 13.70 12.85 11 708203 68 41913053
Cardiac procedure complication 13.68 12.85 16 708198 166 41912955
Cerebral toxoplasmosis 13.67 12.85 9 708205 2089 41911032
Dysuria 13.67 12.85 640 707574 30456 41882665
Blood albumin decreased 13.66 12.85 177 708037 15225 41897896
Aortic valve replacement 13.66 12.85 41 708173 919 41912202
Blood glucose decreased 13.65 12.85 321 707893 13898 41899223
Mediastinal haemorrhage 13.61 12.85 9 708205 39 41913082
Maternal drugs affecting foetus 13.58 12.85 27 708187 3812 41909309
Left ventricular hypertrophy 13.55 12.85 224 707990 9095 41904026
Prothrombin time prolonged 13.55 12.85 227 707987 9242 41903879
Hypomagnesaemia 13.55 12.85 591 707623 27897 41885224
Left ventricular end-diastolic pressure increased 13.54 12.85 17 708197 191 41912930
Autoimmune myositis 13.52 12.85 32 708182 619 41912502
Sinus rhythm 13.50 12.85 25 708189 404 41912717
Hidradenitis 13.49 12.85 6 708208 1735 41911386
Gouty arthritis 13.49 12.85 48 708166 1179 41911942
Brain stem ischaemia 13.47 12.85 16 708198 169 41912952
Pancreatic fistula 13.46 12.85 11 708203 70 41913051
Coronary revascularisation 13.46 12.85 11 708203 70 41913051
Viral infection 13.44 12.85 278 707936 22205 41890916
Physical examination abnormal 13.43 12.85 26 708188 435 41912686
Pulmonary vascular disorder 13.42 12.85 33 708181 655 41912466
Right atrial enlargement 13.39 12.85 20 708194 268 41912853
Renal impairment neonatal 13.34 12.85 6 708208 9 41913112
Vascular encephalopathy 13.31 12.85 15 708199 149 41912972
Cardiomegaly 13.31 12.85 369 707845 16397 41896724
Bronchitis 13.30 12.85 933 707281 46268 41866853
Low birth weight baby 13.29 12.85 236 707978 9719 41903402
Conjunctivitis 13.29 12.85 144 708070 12795 41900326
Angiogram abnormal 13.27 12.85 9 708205 41 41913080
Coronary bypass thrombosis 13.27 12.85 5 708209 3 41913118
Subclavian steal syndrome 13.27 12.85 5 708209 3 41913118
Full blood count increased 13.26 12.85 42 708172 970 41912151
Carotid artery dissection 13.26 12.85 16 708198 172 41912949
Left ventricular enlargement 13.25 12.85 37 708177 795 41912326
Hypocoagulable state 13.24 12.85 42 708172 971 41912150
Chest wall haematoma 13.23 12.85 18 708196 220 41912901
Anastomotic haemorrhage 13.23 12.85 18 708196 220 41912901
Ventricular hyperkinesia 13.23 12.85 18 708196 220 41912901
Pituitary haemorrhage 13.22 12.85 17 708197 196 41912925
Trigger finger 13.19 12.85 43 708171 1009 41912112
Normal tension glaucoma 13.19 12.85 7 708207 18 41913103
Exposure via breast milk 13.18 12.85 13 708201 2464 41910657
Hypertensive nephropathy 13.17 12.85 27 708187 472 41912649
Thrombotic cerebral infarction 13.12 12.85 26 708188 443 41912678
Cardiac perforation 13.11 12.85 11 708203 73 41913048
Optic ischaemic neuropathy 13.10 12.85 85 708129 2690 41910431
Paranasal sinus mucosal hypertrophy 13.07 12.85 10 708204 57 41913064
Type 1 diabetes mellitus 13.03 12.85 47 708167 5440 41907681
Varicose vein 13.02 12.85 56 708158 1506 41911615
Intestinal pseudo-obstruction 12.99 12.85 11 708203 2244 41910877
Streptococcal infection 12.98 12.85 55 708159 6077 41907044
Hepatomegaly 12.98 12.85 129 708085 11656 41901465
Monoparesis 12.97 12.85 89 708125 2871 41910250
Gastrointestinal vascular malformation 12.97 12.85 6 708208 10 41913111
Angiodysplasia 12.96 12.85 36 708178 771 41912350
Intracranial aneurysm 12.95 12.85 61 708153 1707 41911414
Volume blood decreased 12.94 12.85 18 708196 225 41912896
Lung diffusion test decreased 12.94 12.85 38 708176 841 41912280
Carotid endarterectomy 12.93 12.85 10 708204 58 41913063
Intellectual disability 12.93 12.85 8 708206 1919 41911202
Polyneuropathy 12.92 12.85 225 707989 18436 41894685
Dysmorphism 12.90 12.85 22 708192 3294 41909827
Pulmonary nocardiosis 12.90 12.85 7 708207 1805 41911316
Diabetic retinopathy 12.86 12.85 68 708146 1995 41911126

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 5306.74 10.62 8373 1203958 183710 109193258
Gastrointestinal haemorrhage 4658.37 10.62 7278 1205053 158240 109218728
Coronary artery disease 3142.14 10.62 3903 1208428 67787 109309181
Acute myocardial infarction 3050.01 10.62 4162 1208169 79615 109297353
Cerebrovascular accident 2499.66 10.62 5887 1206444 175397 109201571
Cardiac failure congestive 2420.78 10.62 5207 1207124 145793 109231175
Labelled drug-drug interaction medication error 2271.37 10.62 2156 1210175 27146 109349822
Pemphigus 2077.94 10.62 59 1212272 214511 109162457
Hand deformity 2062.80 10.62 75 1212256 218431 109158537
Anti-cyclic citrullinated peptide antibody positive 1939.01 10.62 9 1212322 181975 109194993
Synovitis 1866.85 10.62 368 1211963 273724 109103244
Glossodynia 1826.78 10.62 165 1212166 221839 109155129
Melaena 1756.40 10.62 2895 1209436 65862 109311106
Systemic lupus erythematosus 1710.16 10.62 352 1211979 253986 109122982
Drug ineffective 1709.62 10.62 9751 1202580 1510789 107866179
Upper gastrointestinal haemorrhage 1551.78 10.62 2305 1210026 47791 109329177
Duodenal ulcer perforation 1506.18 10.62 116 1212215 177584 109199384
Folliculitis 1505.29 10.62 81 1212250 167572 109209396
Pericarditis 1475.61 10.62 302 1212029 218812 109158156
Angina pectoris 1475.52 10.62 2536 1209795 59759 109317209
Infusion related reaction 1424.73 10.62 1249 1211082 379913 108997055
Helicobacter infection 1404.19 10.62 171 1212160 181706 109195262
Off label use 1358.51 10.62 10265 1202066 1489920 107887048
Treatment failure 1343.34 10.62 680 1211651 276554 109100414
Drug intolerance 1303.91 10.62 1521 1210810 404991 108971977
Syncope 1234.00 10.62 4940 1207391 197596 109179372
Rheumatic fever 1211.98 10.62 27 1212304 122552 109254416
Irritable bowel syndrome 1211.42 10.62 178 1212153 164037 109212931
Alopecia 1205.32 10.62 1332 1210999 363421 109013547
Muscle injury 1187.39 10.62 94 1212237 140713 109236255
Angina unstable 1167.97 10.62 1153 1211178 15279 109361689
Anaemia 1153.94 10.62 10072 1202259 537014 108839954
Joint swelling 1144.24 10.62 1934 1210397 440911 108936057
Psoriatic arthropathy 1137.77 10.62 369 1211962 196392 109180576
Fibromyalgia 1135.34 10.62 243 1212088 170666 109206302
Wound 1110.47 10.62 592 1211739 233845 109143123
Vascular stent thrombosis 1109.38 10.62 645 1211686 3516 109373452
Cerebral haemorrhage 1095.47 10.62 2288 1210043 62680 109314288
Rhabdomyolysis 1092.75 10.62 3351 1208980 117050 109259918
Arthropathy 1071.83 10.62 944 1211387 286578 109090390
Swelling 1050.42 10.62 1385 1210946 349656 109027312
Sleep disorder due to general medical condition, insomnia type 1001.16 10.62 35 1212296 105608 109271360
Rheumatoid factor positive 945.20 10.62 154 1212177 131486 109245482
Atrial fibrillation 944.09 10.62 4990 1207341 224652 109152316
Hepatic enzyme increased 933.70 10.62 1292 1211039 319600 109057368
Facet joint syndrome 917.86 10.62 32 1212299 96796 109280172
C-reactive protein abnormal 910.73 10.62 161 1212170 129534 109247434
Impaired healing 905.10 10.62 515 1211816 196202 109180766
Acute kidney injury 902.29 10.62 10787 1201544 624643 108752325
Ill-defined disorder 889.56 10.62 304 1212027 156549 109220419
Fall 887.41 10.62 10314 1202017 593168 108783800
Therapeutic product effect decreased 871.51 10.62 835 1211496 243481 109133487
Haemorrhage 868.07 10.62 2860 1209471 103832 109273136
Lip dry 863.23 10.62 60 1212271 100023 109276945
Stomatitis 862.94 10.62 1014 1211317 269228 109107740
Swollen joint count increased 862.28 10.62 10 1212321 83651 109293317
Haematuria 856.03 10.62 2418 1209913 80587 109296381
Haematemesis 844.86 10.62 1948 1210383 57160 109319808
Transient ischaemic attack 833.69 10.62 2034 1210297 61948 109315020
Breast cancer stage III 831.78 10.62 6 1212325 79111 109297857
Discomfort 804.76 10.62 701 1211630 214006 109162962
Lower gastrointestinal haemorrhage 791.21 10.62 995 1211336 17491 109359477
Gastric haemorrhage 779.34 10.62 917 1211414 14998 109361970
Lower respiratory tract infection 775.27 10.62 913 1211418 242193 109134775
Coronary arterial stent insertion 764.55 10.62 584 1211747 5331 109371637
Completed suicide 761.51 10.62 921 1211410 241460 109135508
Drug interaction 757.39 10.62 8599 1203732 491584 108885384
Coronary artery bypass 740.50 10.62 578 1211753 5464 109371504
Blister 728.17 10.62 851 1211480 226525 109150443
Haemoglobin decreased 727.45 10.62 4945 1207386 243782 109133186
Haematoma 727.06 10.62 1826 1210505 56650 109320318
Chest pain 722.83 10.62 6793 1205538 369582 109007386
Joint range of motion decreased 710.36 10.62 225 1212106 121607 109255361
Hypersensitivity 701.45 10.62 2186 1210145 401812 108975156
Musculoskeletal stiffness 696.74 10.62 1250 1211081 278572 109098396
Subdural haematoma 690.96 10.62 1348 1210983 35106 109341862
Coronary artery occlusion 689.52 10.62 858 1211473 14914 109362054
Contraindicated product administered 689.07 10.62 1033 1211298 247234 109129734
Haemorrhage intracranial 681.46 10.62 1176 1211155 27793 109349175
Coronary artery stenosis 677.48 10.62 795 1211536 12963 109364005
Epistaxis 659.18 10.62 3006 1209325 127366 109249602
Haematochezia 655.91 10.62 2758 1209573 112766 109264202
Myocardial ischaemia 651.09 10.62 1101 1211230 25583 109351385
Bursitis 642.04 10.62 310 1212021 129608 109247360
Hypotension 635.81 10.62 8641 1203690 515208 108861760
Aspirin-exacerbated respiratory disease 632.96 10.62 274 1212057 674 109376294
Type 2 diabetes mellitus 621.18 10.62 615 1211716 176617 109200351
Grip strength decreased 609.84 10.62 79 1212252 80095 109296873
Product use issue 609.66 10.62 1593 1210738 310102 109066866
Plasma cell myeloma 595.56 10.62 1778 1210553 61158 109315810
Product use in unapproved indication 581.14 10.62 2723 1209608 444654 108932314
Drug abuse 576.62 10.62 656 1211675 176755 109200213
Deep vein thrombosis postoperative 574.87 10.62 16 1212315 59275 109317693
Inflammation 569.87 10.62 770 1211561 192468 109184500
Blood loss anaemia 569.05 10.62 837 1211494 17188 109359780
Gastric ulcer 556.43 10.62 1301 1211030 38526 109338442
Rheumatoid arthritis 555.36 10.62 1572 1210759 298041 109078927
Bradycardia 553.31 10.62 3251 1209080 152266 109224702
Infection 549.85 10.62 2076 1210255 360124 109016844
Angioedema 537.82 10.62 2324 1210007 96176 109280792
Peripheral venous disease 528.00 10.62 135 1212196 83982 109292986
Sleep disorder 526.83 10.62 852 1211479 197792 109179176
Liver injury 525.87 10.62 523 1211808 149890 109227078
Abdominal discomfort 520.46 10.62 2382 1209949 391476 108985492
Intentional product use issue 519.06 10.62 1223 1211108 246683 109130285
Acute coronary syndrome 510.93 10.62 913 1211418 22199 109354769
Cardiac failure 503.09 10.62 3653 1208678 183973 109192995
Gastrointestinal disorder 485.00 10.62 1221 1211110 240731 109136237
Wound infection 484.58 10.62 225 1212106 96240 109280728
Duodenal ulcer 482.52 10.62 810 1211521 18704 109358264
Condition aggravated 478.43 10.62 5451 1206880 729385 108647583
Hypoglycaemia 467.90 10.62 2510 1209821 113594 109263374
Thrombosis in device 467.11 10.62 420 1211911 4907 109372061
Blepharospasm 461.27 10.62 37 1212294 54814 109322154
Arthralgia 455.31 10.62 5921 1206410 773711 108603257
Febrile neutropenia 453.65 10.62 1858 1210473 314909 109062059
Autoimmune disorder 451.66 10.62 85 1212246 65398 109311570
Mobility decreased 447.08 10.62 1236 1211095 236186 109140782
Blood cholesterol increased 445.09 10.62 842 1211489 183943 109193025
Cerebral infarction 440.80 10.62 1411 1210920 50427 109326541
Dyspnoea 439.77 10.62 15525 1196806 1091347 108285621
Myelosuppression 432.32 10.62 248 1212083 94092 109282876
Sinusitis 429.38 10.62 1733 1210598 294955 109082013
Injury 424.09 10.62 811 1211520 176454 109200514
Rectal haemorrhage 415.86 10.62 2489 1209842 117344 109259624
Lung disorder 415.83 10.62 841 1211490 179206 109197762
Adjustment disorder with depressed mood 414.14 10.62 15 1212316 43868 109333100
Dislocation of vertebra 412.42 10.62 15 1212316 43706 109333262
Obesity 397.50 10.62 393 1211938 112958 109264010
Dizziness 395.35 10.62 10233 1202098 687960 108689008
Pain 394.40 10.62 7740 1204591 947215 108429753
Faeces discoloured 390.88 10.62 1030 1211301 32918 109344050
Hyperkalaemia 390.84 10.62 2690 1209641 133106 109243862
Lower limb fracture 387.44 10.62 170 1212161 75178 109301790
Mitral valve incompetence 385.57 10.62 1013 1211318 32316 109344652
Weight increased 385.55 10.62 2853 1209478 416791 108960177
Migraine 380.24 10.62 821 1211510 170831 109206137
Night sweats 379.87 10.62 549 1211782 133434 109243534
Nail disorder 377.28 10.62 86 1212245 57849 109319119
Subarachnoid haemorrhage 374.94 10.62 933 1211398 28769 109348199
Ischaemic stroke 372.78 10.62 1147 1211184 40116 109336852
Nasopharyngitis 371.96 10.62 2661 1209670 391700 108985268
Product administration error 360.23 10.62 1060 1211271 36157 109340811
Gastritis erosive 359.86 10.62 544 1211787 11456 109365512
Lupus vulgaris 349.37 10.62 4 1212327 33879 109343089
Maternal exposure during pregnancy 348.20 10.62 1522 1210809 253361 109123607
Carotid artery stenosis 347.16 10.62 467 1211864 8796 109368172
X-ray abnormal 346.49 10.62 17 1212314 38100 109338868
Onychomadesis 344.86 10.62 46 1212285 45617 109331351
Dehydration 338.55 10.62 4611 1207720 274900 109102068
Myalgia 334.79 10.62 3821 1208510 218560 109158408
Post procedural haemorrhage 330.42 10.62 603 1211728 14909 109362059
Dyspnoea exertional 324.49 10.62 2103 1210228 101957 109275011
Gastric ulcer haemorrhage 323.37 10.62 472 1211859 9622 109367346
Therapeutic product effect incomplete 322.01 10.62 1310 1211021 222495 109154473
Dry mouth 313.03 10.62 1131 1211200 198817 109178151
Retinitis 308.75 10.62 10 1212321 32317 109344651
C-reactive protein 306.56 10.62 5 1212326 30326 109346642
Osteoarthritis 306.19 10.62 1003 1211328 181620 109195348
Pregnancy 303.59 10.62 91 1212240 50976 109325992
Hemiparesis 299.03 10.62 1110 1211221 42793 109334175
Vascular stent stenosis 295.39 10.62 193 1212138 1336 109375632
Diverticulum intestinal haemorrhagic 290.86 10.62 308 1212023 4455 109372513
Asthenia 290.77 10.62 9736 1202595 679263 108697705
Injection site reaction 288.61 10.62 330 1212001 88740 109288228
Blood creatine phosphokinase increased 287.71 10.62 1570 1210761 71507 109305461
Coeliac disease 287.51 10.62 61 1212270 43126 109333842
Product prescribing error 286.97 10.62 1220 1211111 50111 109326857
Shock haemorrhagic 284.98 10.62 798 1211533 26449 109350519
C-reactive protein increased 281.63 10.62 1328 1211003 216591 109160377
Sciatica 277.59 10.62 363 1211968 92036 109284932
Prescribed overdose 276.78 10.62 331 1212000 87250 109289718
International normalised ratio increased 272.60 10.62 1757 1210574 85015 109291953
Breast cancer stage II 270.66 10.62 6 1212325 27369 109349599
Hemiplegia 268.19 10.62 697 1211634 22085 109354883
Duodenal ulcer haemorrhage 265.03 10.62 381 1211950 7656 109369312
Rash 264.43 10.62 6915 1205416 814049 108562919
Live birth 263.68 10.62 224 1212107 69260 109307708
Premature delivery 262.43 10.62 836 1211495 29796 109347172
Ischaemic cardiomyopathy 260.13 10.62 377 1211954 7634 109369334
Presyncope 254.28 10.62 1137 1211194 47750 109329218
Haemorrhagic stroke 254.14 10.62 504 1211827 13285 109363683
Therapy non-responder 247.39 10.62 888 1211443 156419 109220549
Cardiac disorder 246.06 10.62 1555 1210776 74725 109302243
Hip arthroplasty 242.74 10.62 156 1212175 55657 109321311
Thrombosis 242.56 10.62 2028 1210303 106634 109270334
Coronary artery thrombosis 242.44 10.62 234 1212097 3010 109373958
Blood creatinine increased 242.16 10.62 3067 1209264 179822 109197146
Renal failure 242.09 10.62 3657 1208674 222917 109154051
Intraventricular haemorrhage 241.38 10.62 300 1212031 5207 109371761
Road traffic accident 239.19 10.62 512 1211819 106886 109270082
Incorrect route of product administration 238.85 10.62 210 1212121 63851 109313117
Pericardial haemorrhage 238.02 10.62 290 1212041 4927 109372041
Device expulsion 233.56 10.62 31 1212300 30860 109346108
Gait inability 233.45 10.62 742 1211589 135634 109241334
Pyrexia 231.99 10.62 7796 1204535 890469 108486499
Gastritis 231.48 10.62 1183 1211148 52516 109324452
Product monitoring error 229.35 10.62 377 1211954 8550 109368418
Chronic obstructive pulmonary disease 226.74 10.62 2005 1210326 107153 109269815
Product label confusion 220.28 10.62 6 1212325 22671 109354297
Ventricular tachycardia 218.57 10.62 1106 1211225 48903 109328065
Vascular graft 217.51 10.62 183 1212148 1942 109375026
Vascular pseudoaneurysm 216.14 10.62 248 1212083 3942 109373026
Epilepsy 215.53 10.62 487 1211844 99722 109277246
Loss of consciousness 214.96 10.62 3182 1209149 193124 109183844
Pulmonary fibrosis 213.76 10.62 503 1211828 101539 109275429
Liver function test increased 210.07 10.62 407 1211924 88141 109288827
Orthostatic hypotension 209.65 10.62 1344 1210987 64905 109312063
Renal impairment 209.25 10.62 3062 1209269 185383 109191585
Haemoptysis 208.51 10.62 1419 1210912 69935 109307033
Retroperitoneal haematoma 207.10 10.62 294 1212037 5837 109371131
Lactic acidosis 207.06 10.62 1732 1210599 91079 109285889
Internal haemorrhage 206.34 10.62 385 1211946 9686 109367282
Drug ineffective for unapproved indication 205.91 10.62 519 1211812 102319 109274649
Sinus bradycardia 205.46 10.62 751 1211580 28732 109348236
Blood glucose increased 203.99 10.62 2287 1210044 130209 109246759
Wheezing 202.62 10.62 1804 1210527 253426 109123542
Haemorrhagic transformation stroke 200.93 10.62 205 1212126 2832 109374136
Chronic kidney disease 200.67 10.62 1479 1210852 74812 109302156
Subdural haemorrhage 200.50 10.62 300 1212031 6258 109370710
Toxicity to various agents 199.50 10.62 3889 1208442 476666 108900302
Oedema peripheral 195.75 10.62 4852 1207479 323808 109053160
Coronary artery restenosis 195.66 10.62 136 1212195 1056 109375912
Arteriosclerosis 194.27 10.62 656 1211675 24111 109352857
Hypercholesterolaemia 193.30 10.62 444 1211887 90393 109286575
Bone erosion 193.08 10.62 136 1212195 46235 109330733
Haemorrhagic arteriovenous malformation 192.67 10.62 104 1212227 478 109376490
Malignant neoplasm progression 192.35 10.62 1123 1211208 173444 109203524
Laryngitis 192.14 10.62 113 1212218 42298 109334670
Onychomycosis 190.22 10.62 92 1212239 38439 109338529
Arteriosclerosis coronary artery 188.02 10.62 655 1211676 24463 109352505
Peripheral arterial occlusive disease 186.69 10.62 352 1211979 8928 109368040
Red blood cell sedimentation rate increased 186.54 10.62 359 1211972 77943 109299025
Knee arthroplasty 184.18 10.62 266 1212065 64682 109312286
Small intestinal haemorrhage 184.13 10.62 240 1212091 4378 109372590
Retroperitoneal haemorrhage 183.36 10.62 276 1212055 5789 109371179
Taste disorder 180.35 10.62 273 1212058 65114 109311854
Myopathy 176.65 10.62 639 1211692 24321 109352647
Disease progression 175.28 10.62 1768 1210563 242266 109134702
Hepatic cytolysis 174.01 10.62 208 1212123 54845 109322123
Urticaria 173.11 10.62 2456 1209875 316401 109060567
Cytokine release syndrome 173.07 10.62 316 1212015 69990 109306978
Occult blood positive 172.16 10.62 300 1212031 7145 109369823
Diverticulum 171.58 10.62 464 1211867 15062 109361906
Foot deformity 171.19 10.62 167 1212164 48313 109328655
Iron deficiency anaemia 170.19 10.62 742 1211589 30817 109346151
Adverse event 166.60 10.62 621 1211710 108188 109268780
Maternal exposure timing unspecified 166.49 10.62 18 1212313 20995 109355973
Product quality issue 164.33 10.62 378 1211953 76921 109300047
Dysarthria 163.92 10.62 1524 1210807 82597 109294371
Finger deformity 163.38 10.62 79 1212252 33013 109343955
Ecchymosis 163.20 10.62 489 1211842 16849 109360119
Porphyria acute 162.67 10.62 11 1212320 18769 109358199
Deep vein thrombosis 161.22 10.62 2288 1210043 137599 109239369
Stent placement 160.18 10.62 286 1212045 6948 109370020
Cardiac failure chronic 159.96 10.62 420 1211911 13391 109363577
Hyponatraemia 159.48 10.62 3309 1209022 214344 109162624
Head injury 157.89 10.62 907 1211424 42110 109334858
Back injury 157.50 10.62 172 1212159 47227 109329741
Aphasia 157.02 10.62 1147 1211184 57850 109319118
Hypoaesthesia 154.85 10.62 2466 1209865 311757 109065211
Gastrointestinal vascular malformation haemorrhagic 154.11 10.62 109 1212222 873 109376095
Injection site pain 153.58 10.62 1230 1211101 176692 109200276
Post procedural haematoma 152.96 10.62 166 1212165 2473 109374495
Drug use disorder 152.50 10.62 12 1212319 18062 109358906
Blood pressure decreased 152.26 10.62 1930 1210401 113161 109263807
Systemic infection 151.87 10.62 334 1211997 9485 109367483
Lupus-like syndrome 150.53 10.62 135 1212196 40657 109336311
Blood urea increased 149.45 10.62 1074 1211257 53883 109323085
Drug dependence 147.69 10.62 199 1212132 49821 109327147
Ventricular extrasystoles 147.18 10.62 564 1211767 22077 109354891
Arrhythmia 146.56 10.62 1282 1211049 68293 109308675
Liver disorder 145.76 10.62 936 1211395 141307 109235661
Tricuspid valve incompetence 145.71 10.62 583 1211748 23290 109353678
Abdominal wall haematoma 145.31 10.62 240 1212091 5465 109371503
Extradural haematoma 145.22 10.62 182 1212149 3187 109373781
Therapy partial responder 144.91 10.62 116 1212215 36945 109340023
Diastolic dysfunction 143.45 10.62 377 1211954 12027 109364941
Lacunar infarction 142.38 10.62 251 1212080 6035 109370933
Joint stiffness 142.00 10.62 330 1212001 66913 109310055
Mucosal inflammation 139.92 10.62 560 1211771 95581 109281387
Aortic aneurysm 137.74 10.62 323 1212008 9581 109367387
Full blood count decreased 136.84 10.62 705 1211626 31394 109345574
Intermittent claudication 136.28 10.62 185 1212146 3516 109373452
Peripheral vascular disorder 135.23 10.62 294 1212037 8282 109368686
Suspected suicide 134.34 10.62 8 1212323 15191 109361777
Electrocardiogram abnormal 132.43 10.62 479 1211852 18230 109358738
Therapeutic response decreased 131.81 10.62 576 1211755 95923 109281045
Peripheral swelling 131.60 10.62 3396 1208935 400638 108976330
Atrioventricular block complete 131.16 10.62 501 1211830 19581 109357387
Spinal epidural haematoma 129.99 10.62 125 1212206 1600 109375368
Poisoning deliberate 129.78 10.62 63 1212268 26268 109350700
Haemophagocytic lymphohistiocytosis 129.51 10.62 94 1212237 31465 109345503
Hyperlipidaemia 129.06 10.62 752 1211579 35096 109341872
Oesophageal intramural haematoma 128.47 10.62 56 1212275 141 109376827
Duodenitis 127.99 10.62 300 1212031 8896 109368072
Haematocrit decreased 127.90 10.62 1196 1211135 64921 109312047
Cerebellar haemorrhage 127.32 10.62 168 1212163 3103 109373865
Balance disorder 126.61 10.62 1887 1210444 114673 109262295
Electrocardiogram ST segment elevation 126.59 10.62 298 1212033 8862 109368106
Muscle haemorrhage 126.51 10.62 251 1212080 6618 109370350
Multiple injuries 126.08 10.62 176 1212155 3438 109373530
Sinus node dysfunction 125.76 10.62 295 1212036 8752 109368216
Cardiac tamponade 125.04 10.62 338 1211993 10969 109365999
Intentional product misuse 125.00 10.62 897 1211434 132007 109244961
Heparin-induced thrombocytopenia 124.83 10.62 340 1211991 11084 109365884
Immunodeficiency 124.61 10.62 145 1212186 38693 109338275
Atrioventricular block 124.50 10.62 438 1211893 16439 109360529
Infective pulmonary exacerbation of cystic fibrosis 124.09 10.62 10 1212321 14761 109362207
Ventricular hypertrophy 123.27 10.62 252 1212079 6793 109370175
Loss of personal independence in daily activities 123.15 10.62 1051 1211280 148969 109227999
Hepatic cirrhosis 122.81 10.62 358 1211973 67268 109309700
Pallor 120.77 10.62 1044 1211287 55423 109321545
Exostosis 119.99 10.62 199 1212132 45757 109331211
Hiatus hernia 119.55 10.62 609 1211722 26997 109349971
Osteoporosis 117.95 10.62 522 1211809 86630 109290338
Musculoskeletal pain 117.72 10.62 1360 1210971 181663 109195305
Cytomegalovirus infection 117.54 10.62 264 1212067 54180 109322788
Drug hypersensitivity 117.31 10.62 3939 1208392 450151 108926817
Peripheral ischaemia 116.75 10.62 325 1212006 10733 109366235
Cardiovascular disorder 116.59 10.62 527 1211804 22233 109354735
Acute graft versus host disease 116.26 10.62 6 1212325 12875 109364093
Urinary tract infection 116.21 10.62 4525 1207806 321757 109055211
Cardiac arrest 115.64 10.62 2900 1209431 193853 109183115
Palpitations 115.44 10.62 2417 1209914 156795 109220173
Neurotoxicity 114.69 10.62 178 1212153 42029 109334939
Bundle branch block left 113.38 10.62 355 1211976 12533 109364435
Chest discomfort 113.27 10.62 2599 1209732 171249 109205719
Embolic stroke 111.78 10.62 276 1212055 8467 109368501
Cerebral ischaemia 111.69 10.62 339 1211992 11765 109365203
Drug tolerance decreased 110.47 10.62 84 1212247 27456 109349512
Exposure to toxic agent 110.01 10.62 8 1212323 12850 109364118
Blood pressure increased 109.60 10.62 3655 1208676 254718 109122250
Atrial flutter 109.13 10.62 541 1211790 23721 109353247
Chromaturia 109.03 10.62 621 1211710 28739 109348229
Bronchopulmonary aspergillosis 107.62 10.62 101 1212230 29762 109347206
Injection site erythema 107.39 10.62 599 1211732 93577 109283391
Graft versus host disease 107.35 10.62 36 1212295 18770 109358198
Cerebral haematoma 106.58 10.62 288 1212043 9344 109367624
Circulatory collapse 106.58 10.62 822 1211509 42171 109334797
Haematotoxicity 106.12 10.62 49 1212282 21033 109355935
Aortic valve incompetence 105.53 10.62 312 1212019 10669 109366299
Coordination abnormal 105.40 10.62 551 1211780 24677 109352291
Adverse drug reaction 104.90 10.62 701 1211630 104858 109272110
Glomerular filtration rate decreased 103.97 10.62 607 1211724 28349 109348619
Aortic valve stenosis 103.93 10.62 221 1212110 6129 109370839
Large intestinal haemorrhage 103.79 10.62 149 1212182 2990 109373978
Acute graft versus host disease in skin 103.73 10.62 3 1212328 10737 109366231
Respiratory depression 103.18 10.62 119 1212212 31882 109345086
Arterial occlusive disease 102.53 10.62 385 1211946 14923 109362045
Ear pain 102.41 10.62 274 1212057 52952 109324016
Arterial haemorrhage 101.80 10.62 164 1212167 3655 109373313
Swollen tongue 101.71 10.62 1061 1211270 59301 109317667
Ejection fraction decreased 101.56 10.62 782 1211549 40098 109336870
Sleep disorder due to a general medical condition 101.23 10.62 267 1212064 51845 109325123
Large intestine polyp 100.26 10.62 379 1211952 14738 109362230
Hypertensive crisis 100.24 10.62 530 1211801 23842 109353126
Vertigo 98.92 10.62 1418 1210913 85452 109291516
Neoplasm progression 98.65 10.62 369 1211962 64226 109312742
Blood glucose decreased 98.12 10.62 606 1211725 28882 109348086
Ischaemia 97.92 10.62 269 1212062 8814 109368154
Infusion site reaction 97.24 10.62 36 1212295 17646 109359322
Electrolyte imbalance 96.88 10.62 717 1211614 36311 109340657
Disability 96.79 10.62 113 1212218 30110 109346858
Adenovirus infection 96.53 10.62 6 1212325 10988 109365980
Constipation 96.45 10.62 4822 1207509 352964 109024004
Hyperglycaemia 96.12 10.62 1387 1210944 83703 109293265
Thalamus haemorrhage 94.23 10.62 112 1212219 1852 109375116
Headache 93.14 10.62 8367 1203964 874010 108502958
Adverse reaction 92.27 10.62 113 1212218 29481 109347487
Pulmonary oedema 91.81 10.62 1583 1210748 99076 109277892
Multiple-drug resistance 91.65 10.62 17 1212314 13218 109363750
Ear infection 90.27 10.62 367 1211964 62365 109314603
Diverticulum intestinal 89.80 10.62 308 1212023 11411 109365557
Benign prostatic hyperplasia 89.54 10.62 417 1211914 17817 109359151
Exposure during pregnancy 89.23 10.62 1294 1211037 166130 109210838
Pathogen resistance 89.07 10.62 41 1212290 17631 109359337
Atrioventricular block second degree 88.91 10.62 243 1212088 7938 109369030
Cytomegalovirus infection reactivation 88.64 10.62 45 1212286 18288 109358680
Peptic ulcer 88.55 10.62 232 1212099 7387 109369581
Ventricular hypokinesia 87.93 10.62 297 1212034 10917 109366051
Suicidal ideation 87.84 10.62 635 1211696 93302 109283666
Cerebrovascular disorder 87.72 10.62 151 1212180 3560 109373408
Neuroleptic malignant syndrome 87.52 10.62 149 1212182 33910 109343058
Venoocclusive liver disease 87.00 10.62 29 1212302 15178 109361790
Diabetes mellitus inadequate control 86.89 10.62 592 1211739 29183 109347785
Glycosylated haemoglobin increased 86.67 10.62 498 1211833 23121 109353847
Walking aid user 86.67 10.62 88 1212243 24987 109351981
Injection site swelling 86.11 10.62 366 1211965 61424 109315544
Cardiomegaly 86.10 10.62 581 1211750 28549 109348419
Mallory-Weiss syndrome 85.98 10.62 137 1212194 3024 109373944
Poisoning 85.71 10.62 116 1212215 28989 109347979
Sinus arrest 85.45 10.62 161 1212170 4081 109372887
Pharyngeal haemorrhage 84.18 10.62 90 1212241 1317 109375651
Carotid artery thrombosis 83.43 10.62 264 1212067 9374 109367594
Procedural haemorrhage 83.25 10.62 184 1212147 5243 109371725
Pneumocystis jirovecii pneumonia 82.97 10.62 219 1212112 42516 109334452
Seronegative arthritis 82.96 10.62 21 1212310 13156 109363812
Colitis microscopic 82.47 10.62 328 1212003 13066 109363902
Cytomegalovirus viraemia 82.37 10.62 46 1212285 17718 109359250
Cataract 82.14 10.62 1276 1211055 78209 109298759
Adjustment disorder 82.10 10.62 283 1212048 10512 109366456
Graft versus host disease in gastrointestinal tract 81.51 10.62 4 1212327 8964 109368004
Febrile bone marrow aplasia 81.31 10.62 45 1212286 17420 109359548
Memory impairment 80.91 10.62 1596 1210735 195348 109181620
Accidental exposure to product 80.79 10.62 279 1212052 49729 109327239
Neurologic neglect syndrome 80.77 10.62 255 1212076 9043 109367925
Haemorrhage subcutaneous 80.72 10.62 184 1212147 5355 109371613
Traumatic intracranial haemorrhage 80.62 10.62 90 1212241 1386 109375582
Low density lipoprotein increased 80.58 10.62 279 1212052 10387 109366581
Bundle branch block right 80.57 10.62 307 1212024 11984 109364984
Arterial stenosis 80.45 10.62 94 1212237 1525 109375443
Microcytic anaemia 80.24 10.62 197 1212134 6021 109370947
Suicide attempt 80.15 10.62 735 1211596 102659 109274309
Ventricular dysfunction 79.54 10.62 221 1212110 7290 109369678
Vascular graft occlusion 79.08 10.62 65 1212266 666 109376302
Aspergillus infection 78.61 10.62 99 1212232 25517 109351451
Splenic rupture 78.30 10.62 119 1212212 2518 109374450
High density lipoprotein decreased 77.59 10.62 185 1212146 5548 109371420
Electrocardiogram ST segment depression 76.93 10.62 179 1212152 5282 109371686
Drug tolerance 76.82 10.62 43 1212288 16542 109360426
Epstein-Barr virus infection 76.64 10.62 56 1212275 18682 109358286
Hypomagnesaemia 76.30 10.62 1004 1211327 59366 109317602
Haemorrhoidal haemorrhage 75.93 10.62 228 1212103 7865 109369103
Nocturia 75.81 10.62 378 1211953 16612 109360356
Haemothorax 75.57 10.62 208 1212123 6823 109370145
Exercise tolerance decreased 75.50 10.62 297 1212034 11770 109365198
Blood potassium increased 75.47 10.62 623 1211708 32626 109344342
Vitreous haemorrhage 74.70 10.62 160 1212171 4460 109372508
Hip fracture 74.70 10.62 649 1211682 34502 109342466
Angiopathy 74.54 10.62 238 1212093 8492 109368476
Left ventricular failure 74.27 10.62 284 1212047 11105 109365863
Paraesthesia 73.62 10.62 2389 1209942 274132 109102836
Basal ganglia haemorrhage 73.54 10.62 97 1212234 1791 109375177
Gastrointestinal ulcer 72.91 10.62 151 1212180 4109 109372859
Metabolic acidosis 72.86 10.62 1516 1210815 98228 109278740
Dementia 72.72 10.62 595 1211736 31078 109345890
Haemorrhagic cholecystitis 72.66 10.62 36 1212295 133 109376835
Swollen joint count 72.51 10.62 6 1212325 8668 109368300
Potentiating drug interaction 72.39 10.62 286 1212045 11357 109365611
Gastritis haemorrhagic 72.26 10.62 127 1212204 3046 109373922
Joint destruction 71.73 10.62 16 1212315 10927 109366041
Percutaneous coronary intervention 71.36 10.62 51 1212280 416 109376552
Mediastinal haematoma 71.34 10.62 40 1212291 201 109376767
Peripheral artery stenosis 71.30 10.62 81 1212250 1273 109375695
Carotid artery disease 71.28 10.62 104 1212227 2119 109374849
Renal haemorrhage 70.84 10.62 111 1212220 2414 109374554
Helicobacter gastritis 70.63 10.62 113 1212218 2503 109374465
Blood pressure inadequately controlled 70.63 10.62 214 1212117 7419 109369549
Bone marrow failure 70.36 10.62 360 1211971 57488 109319480
Atrioventricular block first degree 70.35 10.62 326 1212005 13899 109363069
Disorientation 70.18 10.62 1127 1211204 69544 109307424
Peptic ulcer haemorrhage 70.12 10.62 75 1212256 1098 109375870
Dilatation atrial 70.03 10.62 140 1212191 3712 109373256
Immune reconstitution inflammatory syndrome 69.67 10.62 46 1212285 16180 109360788
Vascular stent occlusion 69.59 10.62 42 1212289 248 109376720
Insomnia 69.56 10.62 3236 1209095 357354 109019614
Intentional self-injury 69.53 10.62 196 1212135 37233 109339735
Ageusia 69.36 10.62 410 1211921 19235 109357733
Pruritus 69.29 10.62 5461 1206870 576099 108800869
Nasal oedema 69.27 10.62 198 1212133 6641 109370327
Erectile dysfunction 68.58 10.62 392 1211939 18164 109358804
Ventricular fibrillation 68.58 10.62 724 1211607 40589 109336379
Subcutaneous haematoma 68.47 10.62 121 1212210 2915 109374053
Schizophrenia 68.40 10.62 83 1212248 21743 109355225
Urinary bladder haemorrhage 68.25 10.62 116 1212215 2706 109374262
Hospitalisation 68.22 10.62 1124 1211207 141369 109235599
Graft versus host disease in skin 68.21 10.62 6 1212325 8248 109368720
Arthritis 67.95 10.62 1361 1210970 166225 109210743
Carotid arteriosclerosis 67.87 10.62 121 1212210 2936 109374032
Dysuria 67.71 10.62 981 1211350 59250 109317718
Haemorrhage urinary tract 67.49 10.62 118 1212213 2818 109374150
Dysphagia 67.44 10.62 2182 1210149 151418 109225550
Intestinal haemorrhage 67.17 10.62 205 1212126 7136 109369832
Blood creatine phosphokinase MB increased 67.16 10.62 117 1212214 2786 109374182
Bacterial infection 67.07 10.62 268 1212063 45768 109331200
Cerebral artery occlusion 66.96 10.62 95 1212236 1885 109375083
Neutropenia 66.95 10.62 3389 1208942 371231 109005737
Inappropriate schedule of product administration 66.91 10.62 1709 1210622 201928 109175040
Sudden cardiac death 66.90 10.62 173 1212158 5464 109371504
Hypovolaemic shock 66.89 10.62 327 1212004 14256 109362712
Gastrointestinal angiodysplasia 66.79 10.62 75 1212256 1163 109375805
Myocardial rupture 66.63 10.62 41 1212290 252 109376716
Orthopnoea 66.34 10.62 268 1212063 10753 109366215
Coronary artery dissection 66.29 10.62 75 1212256 1173 109375795
Aneurysm 66.25 10.62 149 1212182 4297 109372671
Coronary artery aneurysm 66.03 10.62 34 1212297 139 109376829
Chronic graft versus host disease 65.80 10.62 12 1212319 9445 109367523
Immune-mediated myositis 65.50 10.62 182 1212149 6004 109370964
Non-cardiac chest pain 65.43 10.62 253 1212078 9945 109367023
Bleeding time prolonged 65.37 10.62 76 1212255 1226 109375742
International normalised ratio decreased 65.35 10.62 219 1212112 8017 109368951
Retinal haemorrhage 65.34 10.62 241 1212090 9260 109367708
Left ventricular hypertrophy 65.12 10.62 303 1212028 12941 109364027
Pulmonary alveolar haemorrhage 65.10 10.62 411 1211920 19739 109357229
Depression 65.03 10.62 2829 1209502 314506 109062462
Therapeutic response shortened 64.22 10.62 143 1212188 29440 109347528
Coronary angioplasty 64.19 10.62 46 1212285 377 109376591
Cardiac aneurysm 63.91 10.62 87 1212244 1658 109375310
Gastrointestinal ulcer haemorrhage 63.08 10.62 84 1212247 1566 109375402
Temperature regulation disorder 62.74 10.62 31 1212300 12795 109364173
Hepatojugular reflux 62.58 10.62 57 1212274 678 109376290
Cough 62.08 10.62 5872 1206459 455769 108921199
Nodule 62.01 10.62 169 1212162 32462 109344506
Immune effector cell-associated neurotoxicity syndrome 62.01 10.62 43 1212288 14739 109362229
Psychotic disorder 61.95 10.62 317 1212014 50620 109326348
Urogenital haemorrhage 61.84 10.62 64 1212267 900 109376068
Injection site pruritus 61.77 10.62 320 1212011 50938 109326030
Cardiogenic shock 61.75 10.62 927 1211404 56411 109320557
Rheumatoid nodule 61.70 10.62 79 1212252 20217 109356751
Haemorrhagic cerebral infarction 61.65 10.62 79 1212252 1416 109375552
Brain stem infarction 61.53 10.62 95 1212236 2039 109374929
Akathisia 61.52 10.62 58 1212273 17055 109359913
Spinal cord haemorrhage 61.49 10.62 52 1212279 556 109376412
Coronary artery perforation 61.39 10.62 27 1212304 70 109376898
Idiopathic pulmonary fibrosis 60.86 10.62 155 1212176 4849 109372119
Mouth haemorrhage 60.83 10.62 301 1212030 13187 109363781
Cross sensitivity reaction 60.14 10.62 165 1212166 5402 109371566
Dystonia 59.99 10.62 120 1212211 25685 109351283
Essential hypertension 59.92 10.62 206 1212125 7641 109369327
Overlap syndrome 59.88 10.62 13 1212318 9046 109367922
Appendicitis 59.84 10.62 140 1212191 28324 109348644
Post transplant lymphoproliferative disorder 59.64 10.62 50 1212281 15563 109361405
Hyperhidrosis 59.61 10.62 2567 1209764 184731 109192237
Cardiac failure acute 59.48 10.62 460 1211871 23618 109353350
Gingival bleeding 59.42 10.62 397 1211934 19442 109357526
Cardiac valve disease 59.40 10.62 180 1212151 6241 109370727
Food allergy 59.25 10.62 79 1212252 19869 109357099
Acute myeloid leukaemia 58.65 10.62 217 1212114 37893 109339075
Angiocardiogram 58.39 10.62 38 1212293 261 109376707
Ascites 58.35 10.62 693 1211638 92115 109284853
Occult blood 58.31 10.62 86 1212245 1770 109375198
Haemarthrosis 58.25 10.62 195 1212136 7134 109369834
Lip swelling 58.05 10.62 828 1211503 49839 109327129
Basilar artery thrombosis 57.86 10.62 43 1212288 375 109376593
Erosive duodenitis 57.84 10.62 96 1212235 2195 109374773
Tongue haematoma 57.77 10.62 36 1212295 227 109376741
Drug resistance 57.71 10.62 371 1211960 56003 109320965
Hypertensive heart disease 57.61 10.62 144 1212187 4452 109372516
Haemoperitoneum 57.52 10.62 159 1212172 5229 109371739
Oesophagitis haemorrhagic 57.46 10.62 52 1212279 613 109376355
Diabetic foot 57.44 10.62 134 1212197 3961 109373007
Prescribed underdose 57.40 10.62 448 1211883 64726 109312242
Oesophageal ulcer 57.30 10.62 205 1212126 7759 109369209
Mental status changes 57.25 10.62 1162 1211169 74960 109302008
Ankylosing spondylitis 57.21 10.62 52 1212279 15560 109361408
Sopor 57.20 10.62 633 1211698 35913 109341055
Haemorrhagic infarction 56.99 10.62 59 1212272 830 109376138
Puncture site haemorrhage 56.98 10.62 54 1212277 678 109376290
Hypophagia 56.75 10.62 851 1211480 51775 109325193
Unintentional medical device removal 56.60 10.62 14 1212317 8909 109368059
Brain stem haemorrhage 56.49 10.62 84 1212247 1742 109375226
Retinal artery occlusion 56.31 10.62 136 1212195 4113 109372855
Haemobilia 56.30 10.62 51 1212280 602 109376366
Pneumonia 56.26 10.62 10665 1201666 866049 108510919
Abnormal loss of weight 55.94 10.62 242 1212089 10015 109366953
Platelet dysfunction 55.83 10.62 46 1212285 473 109376495
Gangrene 55.74 10.62 338 1211993 16003 109360965
Electrocardiogram T wave inversion 55.17 10.62 162 1212169 5518 109371450
Joint dislocation 55.06 10.62 191 1212140 33999 109342969
Conjunctival haemorrhage 54.97 10.62 179 1212152 6454 109370514
Serotonin syndrome 54.75 10.62 401 1211930 58752 109318216
Posterior reversible encephalopathy syndrome 54.64 10.62 189 1212142 33672 109343296
Arteriospasm coronary 54.55 10.62 221 1212110 8879 109368089
Status epilepticus 54.55 10.62 171 1212160 31400 109345568
Haemorrhoids 54.53 10.62 615 1211716 35057 109341911
Asthma 54.49 10.62 2216 1210115 248075 109128893
Cold sweat 54.48 10.62 421 1211910 21610 109355358
Breast cancer stage I 54.46 10.62 8 1212323 7379 109369589
Frequent bowel movements 54.25 10.62 510 1211821 70880 109306088
Coagulopathy 54.06 10.62 686 1211645 40225 109336743
Carotid artery occlusion 53.96 10.62 228 1212103 9337 109367631
Left ventricular dysfunction 53.75 10.62 441 1211890 23052 109353916
Pulmonary vasculitis 53.59 10.62 5 1212326 6555 109370413
Supraventricular tachycardia 53.51 10.62 454 1211877 23968 109353000
Coagulation time abnormal 53.46 10.62 31 1212300 168 109376800
Respiratory symptom 53.32 10.62 51 1212280 14894 109362074
Eructation 53.30 10.62 299 1212032 13758 109363210
Eating disorder 53.22 10.62 545 1211786 30313 109346655
Pulmonary hypertension 53.12 10.62 876 1211455 54344 109322624
Urinary retention 52.83 10.62 1065 1211266 68618 109308350
Creatinine renal clearance decreased 52.36 10.62 414 1211917 21401 109355567
Acute respiratory failure 52.10 10.62 1135 1211196 74125 109302843
Ventricular arrhythmia 51.99 10.62 234 1212097 9853 109367115
Eye haemorrhage 51.86 10.62 261 1212070 11513 109365455
Colitis ischaemic 51.84 10.62 353 1211978 17397 109359571
Dizziness postural 51.64 10.62 305 1212026 14304 109362664
Blindness transient 51.42 10.62 163 1212168 5793 109371175
Oral herpes 51.33 10.62 212 1212119 35868 109341100
Gastrointestinal arteriovenous malformation 51.27 10.62 58 1212273 907 109376061
Gout 51.27 10.62 620 1211711 35946 109341022
BK virus infection 51.27 10.62 41 1212290 13065 109363903
Polycythaemia vera 51.26 10.62 44 1212287 481 109376487
Peripheral coldness 50.79 10.62 363 1211968 18177 109358791
Hypochromic anaemia 50.77 10.62 110 1212221 3091 109373877
Urosepsis 50.65 10.62 537 1211794 30138 109346830
Electrocardiogram Q wave abnormal 50.64 10.62 51 1212280 693 109376275
Haemorrhagic erosive gastritis 50.31 10.62 52 1212279 730 109376238
Angioplasty 50.31 10.62 83 1212248 1888 109375080
Thrombotic thrombocytopenic purpura 50.27 10.62 182 1212149 6929 109370039
Haematoma muscle 50.07 10.62 127 1212204 3963 109373005
Skin haemorrhage 49.98 10.62 453 1211878 24374 109352594
Blood triglycerides increased 49.93 10.62 440 1211891 23486 109353482
Renal cyst 49.90 10.62 356 1211975 17816 109359152
Intracranial aneurysm 49.20 10.62 144 1212187 4896 109372072
Haemodialysis 49.17 10.62 348 1211983 17371 109359597
Troponin increased 49.10 10.62 521 1211810 29245 109347723
Brain natriuretic peptide increased 49.04 10.62 248 1212083 10961 109366007
Cardiac operation 48.98 10.62 161 1212170 5834 109371134
Post procedural complication 48.96 10.62 477 1211854 26181 109350787
Venoocclusive disease 48.91 10.62 6 1212325 6344 109370624
HELLP syndrome 48.86 10.62 54 1212277 822 109376146
Pericardial effusion 48.67 10.62 890 1211441 56327 109320641
Intracardiac thrombus 48.62 10.62 129 1212202 4139 109372829
Aortic aneurysm rupture 48.57 10.62 68 1212263 1332 109375636
Increased tendency to bruise 48.56 10.62 256 1212075 11502 109365466
Compartment syndrome 48.54 10.62 159 1212172 5751 109371217
Metastases to liver 48.45 10.62 211 1212120 35175 109341793
Cardiac murmur 48.37 10.62 447 1211884 24181 109352787
Bronchopulmonary aspergillosis allergic 48.32 10.62 16 1212315 8410 109368558
Tongue oedema 48.30 10.62 199 1212132 8057 109368911
Hyphaema 48.03 10.62 60 1212271 1047 109375921
Pseudomonas infection 48.02 10.62 151 1212180 27702 109349266
Vitamin B12 deficiency 47.94 10.62 228 1212103 9827 109367141
Prothrombin time prolonged 47.89 10.62 339 1211992 16922 109360046
Liver function test abnormal 47.78 10.62 1040 1211291 67910 109309058
Brain contusion 47.68 10.62 73 1212258 1555 109375413
Thrombotic microangiopathy 47.51 10.62 162 1212169 28987 109347981
Bladder tamponade 47.46 10.62 49 1212282 687 109376281
Foetal growth restriction 47.45 10.62 104 1212227 2946 109374022
Peripheral artery occlusion 47.42 10.62 101 1212230 2804 109374164
Anuria 47.41 10.62 441 1211890 23900 109353068
Kounis syndrome 47.41 10.62 158 1212173 5767 109371201
Splenic haematoma 47.39 10.62 35 1212296 302 109376666
No adverse event 47.33 10.62 549 1211782 73290 109303678
Personality disorder 47.32 10.62 271 1212060 12566 109364402
Diabetic ketoacidosis 47.27 10.62 685 1211646 41373 109335595
Device issue 47.24 10.62 206 1212125 34329 109342639
Hypovolaemia 47.01 10.62 402 1211929 21272 109355696
Acute graft versus host disease in intestine 46.87 10.62 4 1212327 5635 109371333
Wound haemorrhage 46.85 10.62 136 1212195 4602 109372366
Flatulence 46.78 10.62 818 1211513 51331 109325637
Lymphopenia 46.61 10.62 254 1212077 39916 109337052
Underdose 46.60 10.62 458 1211873 63096 109313872
Metastases to central nervous system 46.56 10.62 114 1212217 22703 109354265
Human herpesvirus 6 infection 46.55 10.62 8 1212323 6573 109370395
Hypomania 46.54 10.62 27 1212304 10183 109366785
Thrombotic stroke 46.43 10.62 50 1212281 738 109376230
Aortic stenosis 46.39 10.62 273 1212058 12786 109364182
Labile blood pressure 46.36 10.62 91 1212240 2380 109374588
Speech disorder 46.35 10.62 940 1211391 60629 109316339
Electrocardiogram PR prolongation 46.23 10.62 77 1212254 1766 109375202
Subcapsular renal haematoma 46.20 10.62 55 1212276 911 109376057
Lethargy 46.04 10.62 1348 1210983 92228 109284740
Brain herniation 45.98 10.62 206 1212125 8657 109368311
Helicobacter test positive 45.88 10.62 65 1212266 1288 109375680
Pollakiuria 45.85 10.62 710 1211621 43485 109333483
Mucormycosis 45.81 10.62 30 1212301 10598 109366370
Oesophageal haemorrhage 45.73 10.62 78 1212253 1825 109375143
Choroidal haemorrhage 45.64 10.62 28 1212303 171 109376797
Cystitis haemorrhagic 45.53 10.62 40 1212291 12169 109364799
Malignant melanoma in situ 45.48 10.62 112 1212219 3430 109373538
Hypokinesia 45.35 10.62 401 1211930 21425 109355543
Facial paralysis 45.32 10.62 435 1211896 23779 109353189
Pharyngeal oedema 45.21 10.62 322 1212009 16106 109360862
Supraventricular extrasystoles 45.21 10.62 192 1212139 7881 109369087
Stenosis 45.20 10.62 108 1212223 3243 109373725
Inguinal hernia 45.04 10.62 186 1212145 7539 109369429
Pulmonary embolism 44.92 10.62 2825 1209506 211649 109165319
Respiratory disorder 44.88 10.62 533 1211798 70849 109306119
Intra-abdominal haematoma 44.80 10.62 110 1212221 3362 109373606
Jaundice 44.80 10.62 905 1211426 58331 109318637
Aplastic anaemia 44.63 10.62 128 1212203 24180 109352788
Facial paresis 44.53 10.62 158 1212173 5955 109371013
Sensory loss 44.47 10.62 394 1211937 21063 109355905
Bradyarrhythmia 44.41 10.62 137 1212194 4797 109372171
Aortic arteriosclerosis 44.39 10.62 237 1212094 10701 109366267
Diabetic neuropathy 44.39 10.62 173 1212158 6826 109370142
Diverticulitis intestinal haemorrhagic 44.30 10.62 40 1212291 470 109376498
Orthostatic intolerance 44.05 10.62 82 1212249 2059 109374909
Spontaneous haematoma 44.02 10.62 78 1212253 1883 109375085
Cerebral artery stenosis 43.97 10.62 52 1212279 855 109376113
Deafness transitory 43.88 10.62 57 1212274 1036 109375932
Feeling hot 43.82 10.62 718 1211613 90388 109286580
Respiratory tract haemorrhage 43.79 10.62 79 1212252 1935 109375033
Dyspepsia 43.67 10.62 1681 1210650 189284 109187684
Aortic valve replacement 43.58 10.62 70 1212261 1556 109375412
Mite allergy 43.45 10.62 6 1212325 5797 109371171
Reye's syndrome 43.15 10.62 13 1212318 3 109376965
Aortic valve sclerosis 43.12 10.62 76 1212255 1827 109375141
Arteriovenous malformation 43.03 10.62 77 1212254 1874 109375094
Extrasystoles 42.90 10.62 193 1212138 8125 109368843
Cerebral mass effect 42.88 10.62 87 1212244 2332 109374636
Uterine perforation 42.87 10.62 11 1212320 6829 109370139
Periorbital oedema 42.85 10.62 223 1212108 9969 109366999
Cardiomyopathy 42.55 10.62 558 1211773 32967 109344001
Fungal infection 42.55 10.62 354 1211977 50452 109326516
Drug reaction with eosinophilia and systemic symptoms 42.51 10.62 638 1211693 81457 109295511
Labile hypertension 42.51 10.62 42 1212289 557 109376411
Platelet count decreased 42.50 10.62 3003 1209328 227440 109149528
Device difficult to use 42.40 10.62 89 1212242 18716 109358252
Hyperprolactinaemia 42.33 10.62 10 1212321 6565 109370403
Dyslipidaemia 42.25 10.62 310 1212021 15655 109361313
Cerebellar infarction 42.19 10.62 121 1212210 4066 109372902
Infective exacerbation of chronic obstructive airways disease 42.16 10.62 102 1212229 3088 109373880
Carotid bruit 42.09 10.62 46 1212285 691 109376277
Renal artery stenosis 41.82 10.62 112 1212219 3614 109373354
Dysgeusia 41.82 10.62 1034 1211297 68951 109308017
Hepatotoxicity 41.57 10.62 469 1211862 62931 109314037
Sarcoidosis 41.40 10.62 46 1212285 12533 109364435
Amyloid related imaging abnormality-oedema/effusion 41.12 10.62 67 1212264 1508 109375460
Acute lymphocytic leukaemia recurrent 41.01 10.62 7 1212324 5780 109371188
Ischaemic cerebral infarction 40.90 10.62 96 1212235 2849 109374119
Intercepted product preparation error 40.81 10.62 12 1212319 6808 109370160
Prinzmetal angina 40.69 10.62 82 1212249 2187 109374781
Enthesopathy 40.66 10.62 46 1212285 12432 109364536
Naevus flammeus 40.54 10.62 19 1212312 60 109376908
Neck pain 40.53 10.62 1033 1211298 122097 109254871
Nasal disorder 40.40 10.62 120 1212211 4114 109372854
Oesophagitis 40.31 10.62 487 1211844 28228 109348740
Body height decreased 40.26 10.62 225 1212106 10338 109366630
Asthma-chronic obstructive pulmonary disease overlap syndrome 40.15 10.62 10 1212321 6334 109370634
Aplasia 40.09 10.62 18 1212313 7855 109369113
Hyperphosphataemia 39.98 10.62 74 1212257 16307 109360661
Cerebral thrombosis 39.83 10.62 85 1212246 2363 109374605
Ocular retrobulbar haemorrhage 39.82 10.62 25 1212306 160 109376808
Diffuse large B-cell lymphoma recurrent 39.73 10.62 10 1212321 6289 109370679
Gastrointestinal polyp haemorrhage 39.71 10.62 46 1212285 739 109376229
Craniocerebral injury 39.54 10.62 149 1212182 5785 109371183
Paresis 39.50 10.62 130 1212201 4714 109372254
Hypoacusis 39.48 10.62 573 1211758 34618 109342350
Diverticulitis 39.25 10.62 814 1211517 52708 109324260
Infarction 39.09 10.62 137 1212194 5132 109371836
Arterial intramural haematoma 39.02 10.62 28 1212303 230 109376738
Hernia 38.84 10.62 355 1211976 19145 109357823
Type V hyperlipidaemia 38.63 10.62 63 1212268 1419 109375549
Traumatic haemorrhage 38.41 10.62 71 1212260 1773 109375195
Unintended pregnancy 38.40 10.62 4 1212327 4804 109372164
Peripheral artery thrombosis 38.35 10.62 114 1212217 3910 109373058
Erosive oesophagitis 38.30 10.62 96 1212235 2973 109373995
Small intestinal ulcer haemorrhage 38.26 10.62 22 1212309 117 109376851
Spirometry abnormal 38.19 10.62 7 1212324 5490 109371478
Vertebral artery stenosis 38.10 10.62 27 1212304 217 109376751
Diabetic retinopathy 37.88 10.62 105 1212226 3459 109373509
Mitral valve calcification 37.85 10.62 68 1212263 1660 109375308
Catheterisation cardiac 37.63 10.62 151 1212180 6040 109370928
Overdose 37.43 10.62 2138 1210193 231656 109145312
Pulmonary renal syndrome 37.16 10.62 46 1212285 795 109376173
Cerebral microhaemorrhage 37.15 10.62 35 1212296 436 109376532
Gastrointestinal tract mucosal pigmentation 37.03 10.62 57 1212274 1220 109375748
Petechiae 37.01 10.62 405 1211926 22912 109354056
Chronic gastritis 37.00 10.62 137 1212194 5274 109371694
Electrocardiogram T wave abnormal 36.95 10.62 116 1212215 4101 109372867
Drug dose omission by device 36.84 10.62 64 1212267 14452 109362516
Urinary incontinence 36.64 10.62 742 1211589 47845 109329123
Heart rate irregular 36.47 10.62 553 1211778 33721 109343247
Colitis ulcerative 36.45 10.62 612 1211719 76751 109300217
Aortic intramural haematoma 36.29 10.62 24 1212307 170 109376798
Ocular icterus 36.28 10.62 147 1212184 5906 109371062
Blood sodium decreased 36.16 10.62 606 1211725 37713 109339255
Catheter site haematoma 36.13 10.62 33 1212298 394 109376574
Fear of injection 35.97 10.62 27 1212304 8884 109368084
Hypogammaglobulinaemia 35.92 10.62 107 1212224 19969 109356999
Arterial restenosis 35.72 10.62 16 1212315 44 109376924
Hypophosphataemia 35.71 10.62 215 1212116 32967 109344001
Pulmonary haemorrhage 35.57 10.62 305 1212026 16151 109360817
Vision blurred 35.56 10.62 1743 1210588 127279 109249689
Cognitive disorder 35.56 10.62 1232 1211099 86279 109290689
Rectal polyp 35.54 10.62 62 1212269 1478 109375490
Pre-eclampsia 35.50 10.62 188 1212143 8462 109368506
Hypersensitivity myocarditis 35.31 10.62 30 1212301 323 109376645
Muscular weakness 35.24 10.62 3173 1209158 245295 109131673
Platelet function test abnormal 35.11 10.62 23 1212308 160 109376808
Upper respiratory tract infection 35.07 10.62 1134 1211197 130194 109246774
Akinesia 35.06 10.62 104 1212227 3563 109373405
Metastases to bone 34.97 10.62 201 1212130 31171 109345797
Pemphigoid 34.91 10.62 350 1211981 19357 109357611
Cholecystitis acute 34.90 10.62 294 1212037 15488 109361480
Haemorrhagic diathesis 34.90 10.62 169 1212162 7339 109369629
Colonic haematoma 34.88 10.62 18 1212313 74 109376894
Sickle cell anaemia with crisis 34.73 10.62 32 1212299 9513 109367455
Incision site haemorrhage 34.67 10.62 51 1212280 1047 109375921
Lymphocyte count decreased 34.63 10.62 431 1211900 56812 109320156
Respiratory arrest 34.50 10.62 441 1211890 57858 109319110
Hypoglycaemic coma 34.47 10.62 136 1212195 5397 109371571
Euglycaemic diabetic ketoacidosis 34.45 10.62 232 1212099 11391 109365577
Gastroduodenal haemorrhage 34.45 10.62 28 1212303 282 109376686
Paradoxical drug reaction 34.45 10.62 34 1212297 9783 109367185
Silent myocardial infarction 34.40 10.62 41 1212290 680 109376288
Cerebral hyperperfusion syndrome 34.40 10.62 20 1212311 109 109376859
Coronary artery dilatation 34.34 10.62 18 1212313 77 109376891
Necrotising myositis 34.31 10.62 71 1212260 1931 109375037
Cardiac stress test abnormal 34.19 10.62 44 1212287 792 109376176
Weight decreased 34.15 10.62 5733 1206598 462324 108914644
Atrial thrombosis 33.98 10.62 115 1212216 4231 109372737
Dyspnoea at rest 33.98 10.62 181 1212150 8165 109368803
Disturbance in social behaviour 33.96 10.62 7 1212324 5051 109371917
Transplant dysfunction 33.92 10.62 25 1212306 8303 109368665
Electric shock 33.91 10.62 67 1212264 1761 109375207
Dilatation ventricular 33.80 10.62 110 1212221 3965 109373003
Coronary artery insufficiency 33.70 10.62 22 1212309 152 109376816
Scrotal haematoma 33.68 10.62 17 1212314 66 109376902
Anaemia macrocytic 33.67 10.62 164 1212167 7139 109369829
Anti-neutrophil cytoplasmic antibody positive vasculitis 33.63 10.62 133 1212198 5284 109371684
Aortic valve disease 33.59 10.62 75 1212256 2152 109374816
Amenorrhoea 33.52 10.62 31 1212300 9200 109367768
Myositis 33.48 10.62 503 1211828 30613 109346355
Blood glucose fluctuation 33.45 10.62 170 1212161 7528 109369440
Juvenile idiopathic arthritis 33.42 10.62 12 1212319 5995 109370973
Rash vesicular 33.32 10.62 69 1212262 14583 109362385
Vascular device infection 33.30 10.62 83 1212248 16429 109360539
Gastrointestinal toxicity 33.26 10.62 44 1212287 11104 109365864
Femoral neck fracture 33.24 10.62 244 1212087 12323 109364645
Drug-induced liver injury 33.21 10.62 1032 1211299 119035 109257933
Ventricle rupture 33.05 10.62 19 1212312 101 109376867
Virologic failure 32.95 10.62 7 1212324 4945 109372023
Withdrawal syndrome 32.89 10.62 205 1212126 31175 109345793
Tachypnoea 32.89 10.62 611 1211720 38784 109338184
Faeces pale 32.85 10.62 96 1212235 3261 109373707
Oesophageal mucosal dissection 32.83 10.62 13 1212318 23 109376945
Small intestine ulcer 32.77 10.62 44 1212287 827 109376141
Visual acuity reduced 32.67 10.62 515 1211816 31658 109345310
Motor dysfunction 32.57 10.62 410 1211921 23996 109352972
Substance abuse 32.50 10.62 54 1212277 12409 109364559
Device use error 32.45 10.62 31 1212300 9058 109367910
Myocardial necrosis marker increased 32.42 10.62 105 1212226 3775 109373193
Labelled drug-disease interaction medication error 32.37 10.62 29 1212302 337 109376631
Myoglobin blood increased 32.23 10.62 111 1212220 4121 109372847
Subclavian artery stenosis 32.22 10.62 26 1212305 259 109376709
Hypocholesterolaemia 32.20 10.62 15 1212316 6406 109370562
Basilar artery stenosis 32.18 10.62 14 1212317 35 109376933
Tachyarrhythmia 32.18 10.62 177 1212154 8084 109368884
Gravitational oedema 32.16 10.62 67 1212264 1831 109375137
Dermatitis exfoliative 32.16 10.62 224 1212107 11123 109365845
Inferior vena cava dilatation 32.12 10.62 46 1212285 921 109376047
Pancytopenia 32.09 10.62 1925 1210406 207688 109169280
Spinal cord haematoma 32.06 10.62 27 1212304 287 109376681
Unresponsive to stimuli 31.95 10.62 921 1211410 62869 109314099
Thalamic infarction 31.94 10.62 55 1212276 1297 109375671
Basal ganglia infarction 31.93 10.62 40 1212291 700 109376268
Groin pain 31.82 10.62 283 1212048 15145 109361823
Feeling abnormal 31.61 10.62 2345 1209986 178366 109198602
Traumatic haematoma 31.56 10.62 77 1212254 2344 109374624
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits 31.53 10.62 55 1212276 1311 109375657
Haemorrhage coronary artery 31.49 10.62 12 1212319 18 109376950
Large intestinal ulcer 31.48 10.62 136 1212195 5625 109371343
Hypervolaemia 31.44 10.62 737 1211594 48723 109328245
Atheroembolism 31.37 10.62 29 1212302 352 109376616
Uveitis 31.24 10.62 127 1212204 21583 109355385
Hepatitis B reactivation 31.09 10.62 22 1212309 7462 109369506
Hypertensive nephropathy 31.04 10.62 47 1212284 991 109375977
Transplant rejection 30.95 10.62 151 1212180 24416 109352552
Tuberculosis 30.90 10.62 96 1212235 17678 109359290
Periorbital haemorrhage 30.89 10.62 27 1212304 303 109376665
Tumour lysis syndrome 30.87 10.62 204 1212127 30597 109346371
Cardiac pacemaker insertion 30.86 10.62 144 1212187 6157 109370811
Pneumonia cytomegaloviral 30.84 10.62 19 1212312 6935 109370033
Deafness 30.80 10.62 437 1211894 26272 109350696
Device interaction 30.80 10.62 40 1212291 727 109376241
Poor venous access 30.74 10.62 151 1212180 24371 109352597
Ovarian cyst 30.51 10.62 67 1212264 13863 109363105
Exposure via ingestion 30.48 10.62 8 1212323 4892 109372076
Adrenal insufficiency 30.45 10.62 307 1212024 42083 109334885
Coronary artery surgery 30.32 10.62 20 1212311 141 109376827
Diabetic nephropathy 30.28 10.62 96 1212235 3412 109373556
Lymphoproliferative disorder 30.27 10.62 21 1212310 7197 109369771
Troponin T increased 30.27 10.62 110 1212221 4196 109372772
Adenocarcinoma of colon 30.24 10.62 141 1212190 6027 109370941
Blood alkaline phosphatase increased 30.17 10.62 1004 1211327 69931 109307037
Miosis 30.14 10.62 131 1212200 21852 109355116
Orbital haematoma 30.04 10.62 12 1212319 22 109376946
Sleep apnoea syndrome 29.94 10.62 616 1211715 39831 109337137
Product dose omission in error 29.92 10.62 144 1212187 23368 109353600
Intra-abdominal haemorrhage 29.88 10.62 127 1212204 5215 109371753
Implant site haematoma 29.87 10.62 22 1212309 189 109376779
Alanine aminotransferase abnormal 29.78 10.62 35 1212296 9299 109367669
Acute pulmonary oedema 29.70 10.62 301 1212030 16695 109360273
Herpes simplex 29.69 10.62 82 1212249 15682 109361286
Accidental death 29.64 10.62 9 1212322 5000 109371968
Colon cancer 29.60 10.62 293 1212038 16150 109360818
Faecaloma 29.49 10.62 271 1212060 14637 109362331
Autoimmune myositis 29.48 10.62 45 1212286 956 109376012
Drop attacks 29.47 10.62 48 1212283 1080 109375888
Left atrial dilatation 29.44 10.62 96 1212235 3464 109373504
Complication of device insertion 29.44 10.62 32 1212299 8806 109368162
Arterial disorder 29.38 10.62 71 1212260 2148 109374820
Conjunctivitis allergic 29.29 10.62 20 1212311 6911 109370057
Agranulocytosis 29.28 10.62 488 1211843 61272 109315696
Blood potassium decreased 29.26 10.62 789 1211542 53325 109323643
Mitral valve stenosis 29.23 10.62 54 1212277 1348 109375620
Coronary artery reocclusion 29.14 10.62 19 1212312 131 109376837
Pharyngeal haematoma 29.12 10.62 20 1212311 152 109376816
Sedation 29.11 10.62 563 1211768 69120 109307848
Device leakage 29.10 10.62 85 1212246 15963 109361005
Subchorionic haematoma 29.08 10.62 18 1212313 112 109376856
Skin laceration 29.05 10.62 526 1211805 33227 109343741
Joint effusion 29.02 10.62 124 1212207 20781 109356187
Leg amputation 29.01 10.62 107 1212224 4111 109372857
Arterial spasm 29.01 10.62 20 1212311 153 109376815
Philadelphia positive acute lymphocytic leukaemia 29.01 10.62 15 1212316 62 109376906
Hyperaesthesia 28.95 10.62 75 1212256 14652 109362316
Fat embolism 28.88 10.62 33 1212298 522 109376446
Cerebral amyloid angiopathy 28.88 10.62 33 1212298 522 109376446
Coma 28.85 10.62 1029 1211302 116840 109260128
Mucosal erosion 28.83 10.62 82 1212249 2742 109374226
Gastric mucosal lesion 28.75 10.62 50 1212281 1189 109375779
N-terminal prohormone brain natriuretic peptide increased 28.61 10.62 138 1212193 5983 109370985
Periorbital haematoma 28.45 10.62 45 1212286 987 109375981
Eye swelling 28.44 10.62 515 1211816 32533 109344435
Abortion early 28.42 10.62 10 1212321 10 109376958
Low density lipoprotein abnormal 28.40 10.62 33 1212298 532 109376436
Intracranial haematoma 28.38 10.62 45 1212286 989 109375979
Optic ischaemic neuropathy 28.36 10.62 105 1212226 4042 109372926
Cytomegalovirus chorioretinitis 28.26 10.62 22 1212309 7106 109369862
Respiratory alkalosis 28.21 10.62 131 1212200 5590 109371378
Blood prolactin increased 28.09 10.62 8 1212323 4634 109372334
Illness 27.95 10.62 686 1211645 81485 109295483
Azotaemia 27.94 10.62 198 1212133 9887 109367081
Dyspnoea paroxysmal nocturnal 27.87 10.62 75 1212256 2427 109374541
Diarrhoea 27.87 10.62 13331 1199000 1126174 108250794
Spondylitis 27.86 10.62 51 1212280 11287 109365681
Barrett's oesophagus 27.81 10.62 36 1212295 652 109376316
Hypocalcaemia 27.76 10.62 925 1211406 64441 109312527
Cerebral ventricular rupture 27.74 10.62 30 1212301 445 109376523
Candida infection 27.73 10.62 365 1211966 47644 109329324
Blood test abnormal 27.67 10.62 191 1212140 28363 109348605
Facial bones fracture 27.66 10.62 118 1212213 4853 109372115
Myopathy toxic 27.58 10.62 51 1212280 1274 109375694
Tenosynovitis 27.56 10.62 89 1212242 16194 109360774
Cerebral arteriosclerosis 27.52 10.62 40 1212291 812 109376156
Arterial thrombosis 27.52 10.62 86 1212245 3033 109373935
Transfusion 27.50 10.62 412 1211919 25060 109351908
Linear IgA disease 27.44 10.62 108 1212223 4281 109372687
Incision site haematoma 27.42 10.62 20 1212311 169 109376799
Labelled drug-drug interaction issue 27.35 10.62 103 1212228 3998 109372970
Graft thrombosis 27.30 10.62 31 1212300 487 109376481
Blood urine present 27.29 10.62 395 1211936 23850 109353118
Myxoedema coma 27.24 10.62 36 1212295 666 109376302
Chronic coronary syndrome 27.20 10.62 24 1212307 273 109376695
Brain stem stroke 27.19 10.62 38 1212293 743 109376225
Flap necrosis 27.19 10.62 9 1212322 6 109376962
Bezoar 27.18 10.62 102 1212229 3952 109373016
Dust allergy 27.17 10.62 16 1212315 5985 109370983
Palmar-plantar erythrodysaesthesia syndrome 27.08 10.62 303 1212028 40722 109336246
Skin discolouration 27.06 10.62 717 1211614 48329 109328639
Dry eye 27.06 10.62 439 1211892 55354 109321614
Spontaneous haemorrhage 27.06 10.62 48 1212283 1160 109375808
Cardiac ventricular thrombosis 27.05 10.62 86 1212245 3061 109373907
Pulmonary haematoma 26.94 10.62 18 1212313 130 109376838
Gastric ulcer perforation 26.93 10.62 70 1212261 2218 109374750
Oesophageal ulcer haemorrhage 26.92 10.62 42 1212289 910 109376058
Procedural complication 26.88 10.62 171 1212160 8234 109368734
Anal fistula 26.79 10.62 32 1212299 8441 109368527
Hyperventilation 26.77 10.62 179 1212152 8768 109368200
Cushingoid 26.77 10.62 55 1212276 11657 109365311
Viral haemorrhagic cystitis 26.70 10.62 3 1212328 3396 109373572
Hepatitis 26.64 10.62 767 1211564 89287 109287681
Subacute cutaneous lupus erythematosus 26.61 10.62 117 1212214 4877 109372091
Functional gastrointestinal disorder 26.58 10.62 134 1212197 5915 109371053
Acne 26.53 10.62 237 1212094 33283 109343685
Spinal subdural haematoma 26.49 10.62 22 1212309 229 109376739
Intestinal diaphragm disease 26.46 10.62 29 1212302 437 109376531
Drug effective for unapproved indication 26.45 10.62 74 1212257 14093 109362875
Lip oedema 26.43 10.62 158 1212173 7442 109369526
Vessel puncture site haematoma 26.41 10.62 22 1212309 230 109376738
Abdominal pain lower 26.35 10.62 564 1211767 36719 109340249
Computerised tomogram coronary artery abnormal 26.29 10.62 18 1212313 136 109376832
Blue toe syndrome 26.26 10.62 35 1212296 653 109376315
Heart valve incompetence 26.17 10.62 100 1212231 3909 109373059
Viral mutation identified 26.04 10.62 8 1212323 4411 109372557
Putamen haemorrhage 26.02 10.62 31 1212300 514 109376454
COVID-19 25.98 10.62 2322 1210009 242738 109134230
Hemiataxia 25.81 10.62 12 1212319 37 109376931
Neovascular age-related macular degeneration 25.76 10.62 32 1212299 555 109376413
Rebound effect 25.71 10.62 80 1212251 14726 109362242
Venous pressure jugular increased 25.62 10.62 50 1212281 1302 109375666
Rib fracture 25.55 10.62 516 1211815 33254 109343714
Platelet aggregation inhibition 25.54 10.62 20 1212311 190 109376778
Menstruation irregular 25.48 10.62 16 1212315 5781 109371187
Spinal fusion surgery 25.47 10.62 38 1212293 9118 109367850
Sinus rhythm 25.39 10.62 43 1212288 1000 109375968
Degenerative mitral valve disease 25.34 10.62 24 1212307 301 109376667
Coagulation time prolonged 25.34 10.62 80 1212251 2837 109374131
Embolic cerebral infarction 25.33 10.62 53 1212278 1453 109375515
Device related infection 25.26 10.62 294 1212037 39225 109337743
Psoriasis 25.25 10.62 1265 1211066 138728 109238240
Aneurysm ruptured 25.15 10.62 45 1212286 1095 109375873
Vascular procedure complication 25.14 10.62 10 1212321 18 109376950
Chronic gastrointestinal bleeding 24.98 10.62 29 1212302 467 109376501
Vascular occlusion 24.98 10.62 58 1212273 1709 109375259
Dementia Alzheimer's type 24.91 10.62 40 1212291 889 109376079
Vascular dementia 24.91 10.62 40 1212291 889 109376079
Breast cancer female 24.89 10.62 63 1212268 12405 109364563
Toxic anterior segment syndrome 24.87 10.62 4 1212327 3450 109373518
Metastases to lymph nodes 24.87 10.62 83 1212248 14949 109362019
Chest wall haematoma 24.83 10.62 30 1212301 505 109376463
Diffuse large B-cell lymphoma 24.81 10.62 90 1212241 15808 109361160
Neuropathy peripheral 24.74 10.62 2285 1210046 176992 109199976
Therapeutic drug monitoring analysis not performed 24.73 10.62 61 1212270 1870 109375098
Rectal ulcer 24.73 10.62 73 1212258 2494 109374474
Systolic dysfunction 24.72 10.62 105 1212226 4310 109372658
Otitis media staphylococcal 24.67 10.62 7 1212324 0 109376968
Bladder neoplasm 24.67 10.62 61 1212270 1873 109375095
Klebsiella infection 24.63 10.62 124 1212207 19885 109357083
QRS axis abnormal 24.56 10.62 71 1212260 2397 109374571
Heart rate decreased 24.51 10.62 1126 1211205 81630 109295338
Platelet aggregation test 24.49 10.62 12 1212319 43 109376925
Lupus vasculitis 24.46 10.62 32 1212299 586 109376382
Arterial stent insertion 24.40 10.62 15 1212316 92 109376876
Systemic candida 24.39 10.62 45 1212286 9929 109367039
Coronary ostial stenosis 24.31 10.62 18 1212313 156 109376812
Blood calcium decreased 24.30 10.62 539 1211792 35306 109341662
Prostate cancer metastatic 24.24 10.62 113 1212218 4830 109372138
Extravasation blood 24.19 10.62 29 1212302 484 109376484
Abdominal pain upper 24.14 10.62 3406 1208925 345705 109031263
Endocarditis enterococcal 24.13 10.62 25 1212306 352 109376616
Stent-graft endoleak 24.12 10.62 11 1212320 32 109376936
Page kidney 24.04 10.62 13 1212318 60 109376908
Electrocardiogram ST-T change 24.04 10.62 54 1212277 1556 109375412
Leukaemia recurrent 24.01 10.62 3 1212328 3128 109373840
Affect lability 23.98 10.62 311 1212020 18326 109358642
Vertebrobasilar insufficiency 23.91 10.62 25 1212306 356 109376612
Nodal arrhythmia 23.86 10.62 65 1212266 2119 109374849
Bacteraemia 23.86 10.62 324 1212007 42066 109334902
Contrast encephalopathy 23.86 10.62 25 1212306 357 109376611
Duodenitis haemorrhagic 23.85 10.62 17 1212314 138 109376830
Mania 23.85 10.62 132 1212199 20664 109356304
Cystic fibrosis 23.81 10.62 11 1212320 4720 109372248
Thrombolysis 23.80 10.62 22 1212309 267 109376701
Hyperkinesia 23.80 10.62 83 1212248 3101 109373867
Leukopenia 23.74 10.62 1361 1210970 147430 109229538
Musculoskeletal toxicity 23.64 10.62 20 1212311 214 109376754
Spinal osteoarthritis 23.59 10.62 331 1212000 19852 109357116
Extraocular muscle disorder 23.54 10.62 27 1212304 429 109376539
Septic shock 23.52 10.62 1450 1210881 156078 109220890
Hemianopia homonymous 23.50 10.62 52 1212279 1483 109375485
Dry gangrene 23.47 10.62 42 1212289 1022 109375946
Hallucination 23.47 10.62 1348 1210983 100084 109276884
Mood swings 23.41 10.62 150 1212181 22662 109354306
Post procedural stroke 23.41 10.62 15 1212316 100 109376868
Intestinal haematoma 23.33 10.62 24 1212307 335 109376633
Colorectal cancer 23.30 10.62 40 1212291 9074 109367894
Pulmonary vascular disorder 23.27 10.62 42 1212289 1029 109375939
Syringe issue 23.27 10.62 43 1212288 9482 109367486
Giant cell arteritis 23.24 10.62 92 1212239 3657 109373311
Red blood cell sedimentation rate abnormal 23.23 10.62 165 1212166 24344 109352624
Hidradenitis 23.18 10.62 14 1212317 5166 109371802
Anxiety 23.13 10.62 3373 1208958 341705 109035263
Blindness unilateral 23.09 10.62 185 1212146 9601 109367367
Polyarthritis 23.06 10.62 118 1212213 18845 109358123
Weight fluctuation 23.04 10.62 145 1212186 22000 109354968
Ruptured cerebral aneurysm 23.03 10.62 33 1212298 661 109376307
Skin flap necrosis 22.99 10.62 10 1212321 25 109376943
Post procedural myocardial infarction 22.99 10.62 10 1212321 25 109376943
Eye disorder 22.99 10.62 445 1211886 28461 109348507
Subclavian steal syndrome 22.97 10.62 11 1212320 37 109376931
Extremity contracture 22.95 10.62 56 1212275 1705 109375263
Haemorrhagic disorder 22.93 10.62 57 1212274 1756 109375212
Tooth socket haemorrhage 22.90 10.62 18 1212313 172 109376796
Asbestosis 22.90 10.62 17 1212314 148 109376820
Erythema 22.85 10.62 2821 1209510 288626 109088342
Nodal rhythm 22.85 10.62 86 1212245 3337 109373631
Device breakage 22.80 10.62 76 1212255 13693 109363275
Second primary malignancy 22.79 10.62 111 1212220 17957 109359011
Cerebral artery thrombosis 22.76 10.62 54 1212277 1614 109375354
Capillary fragility test 22.72 10.62 10 1212321 26 109376942
Dissociation 22.68 10.62 46 1212285 9796 109367172
Left ventricular enlargement 22.67 10.62 37 1212294 834 109376134
Delirium 22.66 10.62 1229 1211102 133796 109243172
Pancreatitis acute 22.63 10.62 841 1211490 59433 109317535
Brain stem ischaemia 22.58 10.62 23 1212308 317 109376651
Hyperammonaemic encephalopathy 22.54 10.62 16 1212315 5418 109371550
Essential thrombocythaemia 22.50 10.62 25 1212306 383 109376585
Oculogyric crisis 22.47 10.62 7 1212324 3825 109373143
Anticoagulation drug level below therapeutic 22.44 10.62 55 1212276 1679 109375289
Skin toxicity 22.41 10.62 61 1212270 11722 109365246
Cardiac valve replacement complication 22.33 10.62 19 1212312 205 109376763
Cerebral microinfarction 22.26 10.62 8 1212323 9 109376959
Catheter site haemorrhage 22.25 10.62 125 1212206 5755 109371213
Cerebral artery embolism 22.23 10.62 62 1212269 2050 109374918
Gallbladder rupture 22.21 10.62 45 1212286 1205 109375763
Tenosynovitis stenosans 22.19 10.62 6 1212325 3597 109373371
Platelet aggregation increased 22.13 10.62 14 1212317 91 109376877
Cerebrovascular stenosis 22.09 10.62 17 1212314 157 109376811
Myocardial haemorrhage 22.09 10.62 12 1212319 56 109376912
Injection site rash 22.04 10.62 158 1212173 23261 109353707
Blood pressure abnormal 22.03 10.62 357 1211974 22067 109354901
Blood phosphorus increased 22.02 10.62 98 1212233 16242 109360726
Actinic keratosis 22.01 10.62 142 1212189 6871 109370097
Ear haemorrhage 22.01 10.62 68 1212263 2383 109374585
Body temperature increased 21.97 10.62 445 1211886 54268 109322700
Shock 21.91 10.62 755 1211576 52833 109324135
Arterial rupture 21.89 10.62 37 1212294 859 109376109
Toe amputation 21.88 10.62 100 1212231 4238 109372730
Multiple organ dysfunction syndrome 21.86 10.62 1401 1210930 150309 109226659
Restrictive pulmonary disease 21.86 10.62 82 1212249 3177 109373791
Platelet count increased 21.83 10.62 408 1211923 25926 109351042
Anaemia postoperative 21.82 10.62 58 1212273 1863 109375105
Haematocoele 21.82 10.62 8 1212323 10 109376958
Granuloma skin 21.77 10.62 58 1212273 11225 109365743
Extremity necrosis 21.74 10.62 91 1212240 3711 109373257
Pulseless electrical activity 21.72 10.62 280 1212051 16477 109360491
Autoimmune myocarditis 21.67 10.62 31 1212300 620 109376348
Transient global amnesia 21.63 10.62 41 1212290 1044 109375924
Amputation 21.63 10.62 38 1212293 911 109376057
Low density lipoprotein decreased 21.57 10.62 48 1212283 1374 109375594
Drug specific antibody present 21.57 10.62 37 1212294 8397 109368571
Pituitary haemorrhage 21.56 10.62 22 1212309 304 109376664
Pulmonary valve disease 21.54 10.62 23 1212308 336 109376632
Pancreatitis necrotising 21.52 10.62 118 1212213 5383 109371585
Haemorrhagic ascites 21.50 10.62 22 1212309 305 109376663
Cholelithiasis 21.47 10.62 875 1211456 62547 109314421
Blood creatinine abnormal 21.47 10.62 124 1212207 5768 109371200
Cystitis 21.43 10.62 907 1211424 65129 109311839
Prostatic adenoma 21.42 10.62 15 1212316 118 109376850
Polymyositis 21.40 10.62 89 1212242 3619 109373349
Hypertensive emergency 21.39 10.62 83 1212248 3268 109373700
Psychiatric decompensation 21.36 10.62 19 1212312 5746 109371222
Glomerular filtration rate increased 21.36 10.62 58 1212273 1887 109375081
Paronychia 21.35 10.62 57 1212274 11024 109365944
Histoplasmosis disseminated 21.34 10.62 8 1212323 3891 109373077
Postictal paralysis 21.30 10.62 30 1212301 591 109376377
Varicella zoster virus infection 21.27 10.62 23 1212308 6345 109370623
Lumbar spinal stenosis 21.27 10.62 132 1212199 6301 109370667
Respiratory failure 21.25 10.62 2684 1209647 212648 109164320
Abortion incomplete 21.16 10.62 4 1212327 3068 109373900
Lip haematoma 21.15 10.62 6 1212325 0 109376968
Meningitis cryptococcal 21.13 10.62 13 1212318 4749 109372219
Cardiac procedure complication 21.12 10.62 23 1212308 344 109376624
Cardiac death 21.11 10.62 53 1212278 1643 109375325
Coronary revascularisation 21.11 10.62 13 1212318 80 109376888
Sprue-like enteropathy 21.11 10.62 53 1212278 1643 109375325
Implantable defibrillator insertion 21.11 10.62 43 1212288 1156 109375812
Blood pressure diastolic abnormal 21.11 10.62 181 1212150 25634 109351334
Fistula 21.08 10.62 91 1212240 15208 109361760
Microalbuminuria 21.06 10.62 44 1212287 1205 109375763
Prostatic disorder 21.06 10.62 68 1212263 2441 109374527
Aortic bypass 21.02 10.62 10 1212321 33 109376935
Hepatic ischaemia 21.01 10.62 44 1212287 1207 109375761
Polyomavirus viraemia 21.00 10.62 6 1212325 3468 109373500
Gait spastic 20.98 10.62 50 1212281 1499 109375469
Phimosis 20.97 10.62 35 1212296 804 109376164
Hypokalaemia 20.92 10.62 2296 1210035 180152 109196816
Presbyacusis 20.91 10.62 3 1212328 2816 109374152
Hyperkeratosis 20.91 10.62 173 1212158 9066 109367902
Peripheral artery aneurysm 20.90 10.62 27 1212304 488 109376480
Wrong technique in device usage process 20.84 10.62 27 1212304 6874 109370094
Stroke in evolution 20.83 10.62 15 1212316 124 109376844
Pharyngitis streptococcal 20.82 10.62 75 1212256 13202 109363766
Pulmonary tuberculosis 20.82 10.62 43 1212288 9096 109367872
Monoparesis 20.81 10.62 102 1212229 4451 109372517
Trifascicular block 20.81 10.62 18 1212313 199 109376769
Exposure via skin contact 20.80 10.62 74 1212257 13073 109363895
Injection site warmth 20.78 10.62 109 1212222 17296 109359672
Needle fatigue 20.70 10.62 44 1212287 1220 109375748
Behaviour disorder 20.64 10.62 47 1212284 9600 109367368
Diabetic metabolic decompensation 20.63 10.62 91 1212240 3798 109373170
Hyperammonaemia 20.60 10.62 79 1212252 13653 109363315
Hepatic cyst 20.52 10.62 151 1212180 7632 109369336
Respiratory tract infection 20.47 10.62 971 1211360 70646 109306322
Fusarium infection 20.43 10.62 3 1212328 2768 109374200
Choroidal dystrophy 20.38 10.62 10 1212321 36 109376932
Polyuria 20.37 10.62 290 1212041 17448 109359520
Dialysis 20.28 10.62 315 1212016 19304 109357664
Precancerous skin lesion 20.28 10.62 51 1212280 1583 109375385
Mucosal haemorrhage 20.26 10.62 76 1212255 2944 109374024
Anastomotic haemorrhage 20.26 10.62 22 1212309 328 109376640
Coronary artery embolism 20.26 10.62 22 1212309 328 109376640
Vascular access site haematoma 20.26 10.62 8 1212323 14 109376954
Echocardiogram abnormal 20.25 10.62 70 1212261 2604 109374364
Femoral artery aneurysm 20.24 10.62 18 1212313 207 109376761
Thrombocytosis 20.23 10.62 189 1212142 10255 109366713
Back pain 20.17 10.62 4478 1207853 366518 109010450
Diarrhoea haemorrhagic 20.14 10.62 261 1212070 15378 109361590
Mediastinal haemorrhage 20.13 10.62 12 1212319 69 109376899
Hypercoagulation 20.12 10.62 81 1212250 3245 109373723
Panniculitis 20.08 10.62 95 1212236 15487 109361481
Squamous cell carcinoma of skin 20.05 10.62 282 1212049 16921 109360047
Hypoparathyroidism secondary 20.02 10.62 20 1212311 269 109376699
Laryngeal haematoma 20.01 10.62 17 1212314 183 109376785
Product blister packaging issue 19.85 10.62 22 1212309 336 109376632
Heart disease congenital 19.83 10.62 30 1212301 632 109376336
Arterial injury 19.80 10.62 34 1212297 800 109376168
Vascular graft complication 19.79 10.62 17 1212314 186 109376782
Encephalitis 19.78 10.62 123 1212208 18716 109358252
Gouty arthritis 19.78 10.62 51 1212280 1608 109375360
Ileal ulcer 19.78 10.62 54 1212277 1763 109375205
Tremor 19.74 10.62 2519 1209812 199713 109177255
Endoscopy upper gastrointestinal tract 19.72 10.62 15 1212316 136 109376832
Prostatic specific antigen increased 19.72 10.62 217 1212114 12294 109364674
Sinus disorder 19.68 10.62 484 1211847 32244 109344724
Depressive symptom 19.67 10.62 39 1212292 8375 109368593
Catatonia 19.67 10.62 61 1212270 11239 109365729
Obstructive shock 19.63 10.62 15 1212316 137 109376831
Metastases to lung 19.63 10.62 160 1212171 22903 109354065
Actinic elastosis 19.51 10.62 11 1212320 56 109376912
Renal function test abnormal 19.44 10.62 166 1212165 8780 109368188
Muscle strain 19.39 10.62 198 1212133 11004 109365964
Left ventricular end-diastolic pressure increased 19.37 10.62 31 1212300 687 109376281
Total lung capacity decreased 19.33 10.62 30 1212301 7084 109369884
Sinus arrhythmia 19.30 10.62 60 1212271 2110 109374858
Cardiac perforation 19.28 10.62 15 1212316 141 109376827
Neuralgia 19.25 10.62 395 1211936 48083 109328885
Pericardial disease 19.21 10.62 31 1212300 692 109376276
Gestational hypertension 19.16 10.62 61 1212270 2173 109374795
Heart valve stenosis 19.08 10.62 16 1212315 169 109376799
Nephrogenic systemic fibrosis 19.08 10.62 114 1212217 5369 109371599
Laryngotracheal oedema 19.04 10.62 10 1212321 43 109376925
Congestive cardiomyopathy 19.03 10.62 239 1212092 13980 109362988
Strongyloidiasis 19.00 10.62 16 1212315 4970 109371998
Venous stenosis 18.99 10.62 19 1212312 256 109376712
Pleural effusion 18.97 10.62 2226 1210105 175483 109201485
Transitional cell carcinoma 18.95 10.62 77 1212254 3098 109373870
Galactorrhoea 18.92 10.62 11 1212320 4144 109372824
Splenic haemorrhage 18.91 10.62 33 1212298 787 109376181
Rash maculo-papular 18.84 10.62 645 1211686 73577 109303391
Drug specific antibody 18.81 10.62 4 1212327 2824 109374144
Neutrophil count decreased 18.80 10.62 1109 1211222 119832 109257136
Atrial enlargement 18.77 10.62 40 1212291 1111 109375857
Otitis media bacterial 18.75 10.62 6 1212325 3 109376965
Cerebral small vessel ischaemic disease 18.70 10.62 48 1212283 1509 109375459
Metal poisoning 18.59 10.62 13 1212318 102 109376866
Immune-mediated hepatic disorder 18.59 10.62 13 1212318 4437 109372531
Pituitary apoplexy 18.58 10.62 20 1212311 295 109376673
Blood parathyroid hormone decreased 18.56 10.62 77 1212254 13012 109363956
Dermatitis exfoliative generalised 18.55 10.62 60 1212271 10912 109366056
Hypocoagulable state 18.55 10.62 67 1212264 2548 109374420
Urine albumin/creatinine ratio increased 18.52 10.62 39 1212292 1074 109375894
Antineutrophil cytoplasmic antibody positive 18.49 10.62 17 1212314 5059 109371909
Neuritis 18.44 10.62 33 1212298 7366 109369602
Brain scan abnormal 18.42 10.62 48 1212283 1523 109375445
Therapeutic response increased 18.37 10.62 28 1212303 594 109376374
Thrombotic cerebral infarction 18.37 10.62 32 1212299 762 109376206
Muscle rupture 18.35 10.62 97 1212234 4363 109372605
Polyomavirus-associated nephropathy 18.33 10.62 39 1212292 8162 109368806
Aphthous ulcer 18.28 10.62 146 1212185 20990 109355978
Ventricular asystole 18.21 10.62 23 1212308 406 109376562
Fungaemia 18.18 10.62 24 1212307 6062 109370906
Placenta accreta 18.16 10.62 17 1212314 210 109376758
Tendon rupture 18.15 10.62 235 1212096 13843 109363125
Oral allergy syndrome 18.15 10.62 12 1212319 85 109376883
Oesophageal carcinoma 18.14 10.62 65 1212266 11459 109365509
Myoglobinuria 18.12 10.62 41 1212290 1187 109375781
Complications of intestinal transplant 18.12 10.62 8 1212323 21 109376947
Loss of control of legs 18.09 10.62 58 1212273 2074 109374894
Catheterisation cardiac abnormal 18.07 10.62 20 1212311 305 109376663
Arteriovenous fistula 18.06 10.62 46 1212285 1439 109375529
Rales 18.06 10.62 376 1211955 24363 109352605
Lacunar stroke 17.99 10.62 26 1212305 525 109376443
Tinnitus 17.98 10.62 824 1211507 59716 109317252
Acidosis 17.96 10.62 347 1211984 22184 109354784
Affective disorder 17.96 10.62 63 1212268 11178 109365790
Cerebral atrophy 17.90 10.62 165 1212166 8920 109368048
Renal tubular necrosis 17.83 10.62 449 1211882 30026 109346942
Interventricular septum rupture 17.82 10.62 9 1212322 35 109376933
Presbyoesophagus 17.81 10.62 7 1212324 12 109376956
Mitral valve thickening 17.80 10.62 31 1212300 738 109376230
Mitral valve prolapse 17.79 10.62 62 1212269 2316 109374652
Electrocardiogram P wave abnormal 17.78 10.62 22 1212309 380 109376588
Injection site urticaria 17.77 10.62 113 1212218 17102 109359866
Wound haematoma 17.77 10.62 15 1212316 160 109376808
Arthrodesis 17.76 10.62 4 1212327 2714 109374254
Joint ankylosis 17.74 10.62 3 1212328 2494 109374474
Heart valve replacement 17.73 10.62 40 1212291 1156 109375812
Peripartum haemorrhage 17.62 10.62 5 1212326 0 109376968
Eye excision 17.57 10.62 11 1212320 70 109376898
Urine flow decreased 17.57 10.62 44 1212287 1362 109375606
Vascular graft thrombosis 17.57 10.62 18 1212313 250 109376718
Laryngeal pain 17.55 10.62 119 1212212 5856 109371112
Blood triglycerides decreased 17.53 10.62 17 1212314 220 109376748
Fracture 17.53 10.62 375 1211956 24413 109352555
Lung opacity 17.50 10.62 67 1212264 11585 109365383
Nonreassuring foetal heart rate pattern 17.46 10.62 7 1212324 13 109376955
Enterococcal infection 17.46 10.62 141 1212190 20225 109356743
Acquired diaphragmatic eventration 17.42 10.62 31 1212300 751 109376217
Red blood cell count decreased 17.42 10.62 887 1211444 65036 109311932
Hypersensitivity vasculitis 17.40 10.62 133 1212198 6804 109370164
Vessel puncture site haemorrhage 17.39 10.62 16 1212315 193 109376775
Mydriasis 17.39 10.62 157 1212174 22000 109354968
Dieulafoy's vascular malformation 17.37 10.62 8 1212323 24 109376944
Ketoacidosis 17.32 10.62 178 1212153 9909 109367059
Diabetic gangrene 17.29 10.62 17 1212314 224 109376744
Urethral haemorrhage 17.26 10.62 25 1212306 506 109376462
Mycobacterium chelonae infection 17.22 10.62 6 1212325 3054 109373914
Cholestatic liver injury 17.17 10.62 139 1212192 7237 109369731
Diabetic foot infection 17.13 10.62 33 1212298 851 109376117
Cardiac discomfort 17.13 10.62 44 1212287 1384 109375584
Haemodynamic instability 17.08 10.62 349 1211982 22539 109354429
Pericardial rub 17.05 10.62 6 1212325 6 109376962
Anaemia vitamin B12 deficiency 17.04 10.62 40 1212291 1187 109375781
Drug withdrawal syndrome 16.97 10.62 304 1212027 37750 109339218
Micturition urgency 16.95 10.62 302 1212029 19018 109357950
Infection reactivation 16.95 10.62 12 1212319 4069 109372899
Ventricular internal diameter abnormal 16.94 10.62 17 1212314 230 109376738
Somnolence 16.89 10.62 2935 1209396 294514 109082454
Pulmonary thrombosis 16.87 10.62 229 1212102 13634 109363334
Limb injury 16.86 10.62 536 1211795 37100 109339868
Prostate cancer stage I 16.86 10.62 4 1212327 2618 109374350
Spur cell anaemia 16.81 10.62 13 1212318 121 109376847
Aortic dissection 16.80 10.62 102 1212229 4831 109372137
Retinal vascular occlusion 16.78 10.62 27 1212304 601 109376367
Aortic valve calcification 16.76 10.62 33 1212298 865 109376103
Amaurosis fugax 16.75 10.62 61 1212270 2329 109374639
Skin wrinkling 16.75 10.62 46 1212285 1507 109375461
Haemoglobin abnormal 16.73 10.62 162 1212169 8876 109368092
Pneumonia fungal 16.73 10.62 94 1212237 14660 109362308
Cheyne-Stokes respiration 16.72 10.62 25 1212306 521 109376447
Cervicobrachial syndrome 16.71 10.62 39 1212292 1153 109375815
Device inappropriate shock delivery 16.71 10.62 10 1212321 58 109376910
Angiodysplasia 16.71 10.62 45 1212286 1457 109375511
JC virus infection 16.70 10.62 20 1212311 5270 109371698
Acute myeloid leukaemia recurrent 16.69 10.62 19 1212312 5120 109371848
Chronic left ventricular failure 16.66 10.62 41 1212290 1255 109375713
Therapy interrupted 16.65 10.62 417 1211914 49405 109327563
Shoulder arthroplasty 16.63 10.62 81 1212250 3526 109373442
Nephropathy 16.61 10.62 223 1212108 13244 109363724
Mitral valve disease 16.58 10.62 78 1212253 3347 109373621
Bladder transitional cell carcinoma 16.57 10.62 68 1212263 2748 109374220
Ventricular hyperkinesia 16.56 10.62 19 1212312 302 109376666
Vascular calcification 16.53 10.62 38 1212293 1112 109375856
Carcinogenicity 16.53 10.62 14 1212317 150 109376818
Inspiratory capacity abnormal 16.49 10.62 12 1212319 101 109376867
Electrocardiogram ST segment abnormal 16.48 10.62 50 1212281 1735 109375233
Gastric ulcer helicobacter 16.47 10.62 8 1212323 28 109376940
Left atrial enlargement 16.46 10.62 49 1212282 1682 109375286
Low cardiac output syndrome 16.41 10.62 37 1212294 1069 109375899
Angiogram 16.39 10.62 13 1212318 126 109376842
Eosinophilic granulomatosis with polyangiitis 16.34 10.62 61 1212270 10625 109366343
Tumour haemorrhage 16.34 10.62 106 1212225 5139 109371829
Spinal subarachnoid haemorrhage 16.31 10.62 10 1212321 61 109376907
Muscle necrosis 16.27 10.62 50 1212281 1747 109375221
Diabetes mellitus 16.27 10.62 1283 1211048 98098 109278870
Embolism 16.26 10.62 260 1212071 16029 109360939
Systemic mycosis 16.25 10.62 11 1212320 3818 109373150
Localised infection 16.24 10.62 601 1211730 42447 109334521
Arteriovenous fistula operation 16.23 10.62 20 1212311 344 109376624
Finger amputation 16.20 10.62 32 1212299 841 109376127
Dementia with Lewy bodies 16.19 10.62 36 1212295 1030 109375938
Multiple sclerosis relapse 16.12 10.62 423 1211908 49817 109327151
Face injury 16.02 10.62 94 1212237 4398 109372570
Visual field defect 16.01 10.62 175 1212156 9897 109367071
Left-to-right cardiac shunt 15.97 10.62 15 1212316 186 109376782
Vasospasm 15.96 10.62 46 1212285 1550 109375418
Vessel perforation 15.96 10.62 7 1212324 18 109376950
Scan myocardial perfusion abnormal 15.95 10.62 14 1212317 158 109376810
Blood pressure systolic decreased 15.94 10.62 221 1212110 13220 109363748
Gastrointestinal mucosal disorder 15.93 10.62 40 1212291 1240 109375728
Lateral medullary syndrome 15.93 10.62 10 1212321 64 109376904
Blood viscosity decreased 15.93 10.62 10 1212321 64 109376904
Fluid intake reduced 15.91 10.62 131 1212200 6855 109370113
Rhinitis perennial 15.85 10.62 16 1212315 218 109376750
Anastomotic infection 15.83 10.62 13 1212318 133 109376835
Interstitial lung disease 15.83 10.62 1313 1211018 138021 109238947
Blood pressure systolic abnormal 15.83 10.62 185 1212146 24665 109352303
Euphoric mood 15.83 10.62 47 1212284 8780 109368188
Contrast media reaction 15.80 10.62 60 1212271 2338 109374630
Coronary vascular graft occlusion 15.75 10.62 6 1212325 9 109376959
Androgenetic alopecia 15.73 10.62 17 1212314 252 109376716
Aortic aneurysm repair 15.69 10.62 7 1212324 19 109376949
Aortic bruit 15.68 10.62 17 1212314 253 109376715
Bladder neoplasm surgery 15.67 10.62 8 1212323 32 109376936
Urethral fistula 15.67 10.62 8 1212323 32 109376936
Medical device site haemorrhage 15.66 10.62 15 1212316 191 109376777
Musculoskeletal discomfort 15.66 10.62 353 1211978 23185 109353783
Nail ridging 15.65 10.62 25 1212306 553 109376415
Urinary straining 15.63 10.62 9 1212322 48 109376920
Anal abscess 15.56 10.62 70 1212261 11568 109365400
Prostatitis 15.56 10.62 98 1212233 4703 109372265
Anaemia of malignant disease 15.54 10.62 34 1212297 962 109376006
Mouth ulceration 15.53 10.62 405 1211926 47733 109329235
Acute generalised exanthematous pustulosis 15.51 10.62 157 1212174 21507 109355461
Eyelid haematoma 15.49 10.62 12 1212319 112 109376856
Lipoprotein (a) increased 15.49 10.62 12 1212319 112 109376856
Angiogram abnormal 15.49 10.62 9 1212322 49 109376919
Oropharyngeal pain 15.48 10.62 1274 1211057 134002 109242966
Mesenteric arterial occlusion 15.47 10.62 17 1212314 257 109376711
Bile duct stone 15.45 10.62 120 1212211 6169 109370799
Obliterative bronchiolitis 15.39 10.62 11 1212320 3712 109373256
Cholestasis 15.39 10.62 565 1211766 63953 109313015
Yellow skin 15.39 10.62 87 1212244 4015 109372953
Genital erosion 15.38 10.62 30 1212301 781 109376187
Anal haemorrhage 15.38 10.62 100 1212231 4852 109372116
Feeding disorder 15.37 10.62 324 1212007 21038 109355930
Reocclusion 15.37 10.62 6 1212325 10 109376958
Capillary fragility increased 15.37 10.62 6 1212325 10 109376958
Generalised tonic-clonic seizure 15.36 10.62 469 1211862 54211 109322757
Carotid endarterectomy 15.34 10.62 14 1212317 167 109376801
Blood pressure diastolic increased 15.31 10.62 132 1212199 18675 109358293
Anticoagulation drug level above therapeutic 15.31 10.62 95 1212236 4535 109372433
Cardiac stress test 15.30 10.62 5 1212326 3 109376965
Coronary bypass thrombosis 15.30 10.62 5 1212326 3 109376965
Decompressive craniectomy 15.30 10.62 5 1212326 3 109376965
Arteriogram coronary abnormal 15.30 10.62 5 1212326 3 109376965
Cardiac perfusion defect 15.30 10.62 8 1212323 34 109376934
Tracheal haemorrhage 15.30 10.62 30 1212301 784 109376184
Anastomotic ulcer haemorrhage 15.30 10.62 13 1212318 140 109376828
Large intestinal ulcer haemorrhage 15.28 10.62 19 1212312 330 109376638
Prostatomegaly 15.28 10.62 89 1212242 4153 109372815
Pelvic pain 15.27 10.62 107 1212224 15835 109361133
Rotator cuff syndrome 15.27 10.62 264 1212067 16530 109360438
Tonsillitis 15.26 10.62 43 1212288 8170 109368798
Abortion spontaneous 15.24 10.62 274 1212057 34008 109342960
Blood homocysteine increased 15.23 10.62 22 1212309 444 109376524
Wrong technique in product usage process 15.23 10.62 792 1211539 86556 109290412
Cerebrovascular insufficiency 15.23 10.62 13 1212318 141 109376827
Atrial septal defect 15.22 10.62 56 1212275 2149 109374819
Irritability 15.22 10.62 403 1211928 47406 109329562
Carotid artery dissection 15.20 10.62 21 1212310 406 109376562
Concomitant disease progression 15.19 10.62 79 1212252 3531 109373437
Sinonasal obstruction 15.17 10.62 20 1212311 369 109376599
ECG signs of myocardial ischaemia 15.16 10.62 21 1212310 407 109376561
Neutropenic colitis 15.15 10.62 42 1212289 8023 109368945
Inappropriate antidiuretic hormone secretion 15.14 10.62 482 1211849 33369 109343599
Haptoglobin increased 15.13 10.62 16 1212315 231 109376737
Dysstasia 15.10 10.62 471 1211860 32515 109344453
Troponin I increased 15.08 10.62 107 1212224 5345 109371623
Hypertensive angiopathy 15.08 10.62 11 1212320 93 109376875
Parkinson's disease 15.05 10.62 44 1212287 1495 109375473
Renal disorder 15.03 10.62 675 1211656 48804 109328164
Breast cancer 15.02 10.62 315 1212016 38227 109338741
Metabolic alkalosis 15.01 10.62 109 1212222 5486 109371482
Meniere's disease 15.01 10.62 13 1212318 144 109376824
Vascular resistance pulmonary decreased 14.99 10.62 10 1212321 72 109376896
Rectosigmoid cancer 14.98 10.62 19 1212312 337 109376631
Platelet count normal 14.96 10.62 7 1212324 22 109376946
Middle ear effusion 14.94 10.62 64 1212267 2637 109374331
Antiphospholipid syndrome 14.91 10.62 61 1212270 2462 109374506
Oesophagitis ulcerative 14.85 10.62 45 1212286 1560 109375408
Blood lactic acid increased 14.85 10.62 250 1212081 15571 109361397
Rhythm idioventricular 14.84 10.62 29 1212302 756 109376212
Postpericardiotomy syndrome 14.78 10.62 8 1212323 37 109376931
Polyp 14.78 10.62 171 1212160 9809 109367159
Lung diffusion test decreased 14.77 10.62 46 1212285 1619 109375349
Testicular oedema 14.77 10.62 10 1212321 74 109376894
Light chain analysis increased 14.76 10.62 58 1212273 2297 109374671
Oliguria 14.76 10.62 287 1212044 18370 109358598
Cholecystitis 14.75 10.62 380 1211951 25502 109351466
Anal fissure 14.73 10.62 57 1212274 9824 109367144
Gait disturbance 14.72 10.62 3354 1208977 274854 109102114
Stenotrophomonas infection 14.71 10.62 26 1212305 5832 109371136
Acute left ventricular failure 14.69 10.62 57 1212274 2244 109374724
Biopsy intestine abnormal 14.69 10.62 6 1212325 12 109376956
Otolithiasis 14.69 10.62 6 1212325 12 109376956
Malignant atrophic papulosis 14.69 10.62 6 1212325 12 109376956
Sternal injury 14.69 10.62 6 1212325 12 109376956
Monoclonal immunoglobulin present 14.68 10.62 61 1212270 2479 109374489
Aortic occlusion 14.68 10.62 19 1212312 344 109376624
Idiopathic intracranial hypertension 14.68 10.62 13 1212318 3939 109373029
Urethral injury 14.67 10.62 9 1212322 55 109376913
Hyperbilirubinaemia 14.65 10.62 242 1212089 30429 109346539
Device occlusion 14.64 10.62 241 1212090 14944 109362024
Growth retardation 14.64 10.62 5 1212326 2577 109374391
Placental insufficiency 14.63 10.62 39 1212292 1255 109375713
Premature rupture of membranes 14.62 10.62 94 1212237 4543 109372425
Device deployment issue 14.61 10.62 15 1212316 4238 109372730
Anti factor VIII antibody positive 14.61 10.62 11 1212320 98 109376870
Hydrocephalus 14.58 10.62 176 1212155 10199 109366769
Amnesia 14.58 10.62 977 1211354 104431 109272537
Skin infection 14.56 10.62 167 1212164 22342 109354626
Retinal disorder 14.56 10.62 58 1212273 2312 109374656
Cerebellar stroke 14.55 10.62 31 1212300 861 109376107
Vertebral artery dissection 14.55 10.62 15 1212316 210 109376758
Accelerated hypertension 14.53 10.62 29 1212302 768 109376200
Umbilical haemorrhage 14.52 10.62 7 1212324 24 109376944
Dressler's syndrome 14.52 10.62 7 1212324 24 109376944
Platelet disorder 14.49 10.62 79 1212252 3596 109373372
Hallucination, auditory 14.41 10.62 203 1212128 26194 109350774
Throat irritation 14.39 10.62 462 1211869 53090 109323878
Conjunctival pallor 14.39 10.62 14 1212317 182 109376786
Retinal vein occlusion 14.38 10.62 84 1212247 3923 109373045
Throat clearing 14.38 10.62 89 1212242 4244 109372724
Eye contusion 14.36 10.62 67 1212264 2865 109374103
Vertigo positional 14.33 10.62 83 1212248 3865 109373103
Intracranial mass 14.32 10.62 58 1212273 2330 109374638
Drug level decreased 14.31 10.62 132 1212199 18416 109358552
Intervertebral discitis 14.30 10.62 128 1212203 6862 109370106
Cholangitis sclerosing 14.27 10.62 11 1212320 3571 109373397
Deformity 14.26 10.62 60 1212271 10100 109366868
Brain compression 14.25 10.62 28 1212303 733 109376235
Benign gastrointestinal neoplasm 14.21 10.62 12 1212319 128 109376840
Placental infarction 14.21 10.62 12 1212319 128 109376840
Butterfly rash 14.20 10.62 3 1212328 2128 109374840
Hypoxic-ischaemic encephalopathy 14.20 10.62 154 1212177 8693 109368275
Cutaneous vasculitis 14.18 10.62 207 1212124 12522 109364446
Pneumatosis intestinalis 14.17 10.62 47 1212284 8482 109368486
Contusion 14.17 10.62 2294 1210037 231067 109145901
Spinal epidural haemorrhage 14.16 10.62 18 1212313 320 109376648
Heart sounds abnormal 14.14 10.62 42 1212289 1440 109375528
Post-traumatic stress disorder 14.13 10.62 122 1212209 6474 109370494
Malignant melanoma 14.11 10.62 262 1212069 16629 109360339
Endometriosis 14.10 10.62 16 1212315 4318 109372650
SARS-CoV-2 test false negative 14.10 10.62 4 1212327 0 109376968
Anginal equivalent 14.10 10.62 4 1212327 0 109376968
Peripheral endarterectomy 14.10 10.62 4 1212327 0 109376968
Emergency care examination abnormal 14.10 10.62 4 1212327 0 109376968
Incision site ulcer 14.10 10.62 4 1212327 0 109376968
Face lift 14.10 10.62 4 1212327 0 109376968
Traumatic arthropathy 14.10 10.62 4 1212327 0 109376968
Mood altered 14.06 10.62 158 1212173 21217 109355751
Macular fibrosis 13.99 10.62 27 1212304 697 109376271
Hepatitis B 13.97 10.62 56 1212275 9556 109367412
Cerebellar haematoma 13.95 10.62 25 1212306 609 109376359
Normal newborn 13.95 10.62 163 1212168 21733 109355235
Pulse absent 13.93 10.62 187 1212144 11105 109365863
Total cholesterol/HDL ratio decreased 13.93 10.62 9 1212322 61 109376907
Subclavian artery occlusion 13.92 10.62 13 1212318 160 109376808
Carcinoma in situ of skin 13.92 10.62 14 1212317 190 109376778
Prostatic haemorrhage 13.92 10.62 14 1212317 190 109376778
Aspiration 13.91 10.62 243 1212088 30290 109346678
Bronchial haemorrhage 13.90 10.62 40 1212291 1347 109375621
Fractional exhaled nitric oxide increased 13.86 10.62 28 1212303 748 109376220
Vascular encephalopathy 13.86 10.62 29 1212302 795 109376173
Venous occlusion 13.85 10.62 37 1212294 1192 109375776
Electrocardiogram change 13.82 10.62 40 1212291 1351 109375617
Pulmonary toxicity 13.81 10.62 126 1212205 17620 109359348
Arteriovenous fistula site haemorrhage 13.81 10.62 19 1212312 366 109376602
Dermatitis acneiform 13.80 10.62 82 1212249 12613 109364355
Flushing 13.78 10.62 975 1211356 103761 109273207
Muscle atrophy 13.77 10.62 213 1212118 13041 109363927
Puncture site haematoma 13.77 10.62 16 1212315 258 109376710
Cutaneous lupus erythematosus 13.76 10.62 75 1212256 3413 109373555
Malignant neoplasm of unknown primary site 13.74 10.62 28 1212303 753 109376215
Acute febrile neutrophilic dermatosis 13.73 10.62 97 1212234 4839 109372129
Postresuscitation encephalopathy 13.70 10.62 8 1212323 44 109376924
Pustular psoriasis 13.69 10.62 90 1212241 13515 109363453
Genitourinary tract infection 13.68 10.62 17 1212314 295 109376673
Heart transplant rejection 13.68 10.62 51 1212280 1970 109374998
Myocardial necrosis 13.67 10.62 23 1212308 532 109376436
Scleritis 13.66 10.62 24 1212307 5396 109371572
Right atrial hypertrophy 13.64 10.62 26 1212305 665 109376303
Change of bowel habit 13.64 10.62 65 1212266 2804 109374164
Pulmonary valve incompetence 13.61 10.62 62 1212269 2624 109374344
Complications of transplanted heart 13.59 10.62 21 1212310 451 109376517
Antipsychotic drug level increased 13.58 10.62 36 1212295 6979 109369989
Acquired haemophilia 13.53 10.62 61 1212270 2570 109374398
Borderline glaucoma 13.53 10.62 6 1212325 16 109376952
Lacrimal haemorrhage 13.52 10.62 7 1212324 29 109376939
Scedosporium infection 13.52 10.62 5 1212326 2453 109374515
Allergy to chemicals 13.52 10.62 10 1212321 3315 109373653
Essential tremor 13.52 10.62 48 1212283 1810 109375158
Pneumocystis jirovecii infection 13.51 10.62 17 1212314 4383 109372585
Ear pruritus 13.50 10.62 38 1212293 7222 109369746
Product dose omission issue 13.49 10.62 3224 1209107 318558 109058410
Hallucination, gustatory 13.47 10.62 9 1212322 65 109376903
Feeling cold 13.43 10.62 477 1211854 33510 109343458
Lumbar radiculopathy 13.43 10.62 60 1212271 2518 109374450
Plasma cell myeloma recurrent 13.42 10.62 127 1212204 6915 109370053
Paralysis 13.39 10.62 243 1212088 15357 109361611
Monoplegia 13.38 10.62 96 1212235 4813 109372155
Expiratory reserve volume decreased 13.36 10.62 12 1212319 140 109376828
Congenital aortic valve stenosis 13.34 10.62 7 1212324 30 109376938
Bone density decreased 13.33 10.62 112 1212219 15930 109361038
Hyperreflexia 13.33 10.62 56 1212275 9429 109367539
Carotid artery stent insertion 13.32 10.62 5 1212326 7 109376961
Nocardiosis 13.32 10.62 40 1212291 7446 109369522
Nervousness 13.31 10.62 512 1211819 36339 109340629
Lymphoma 13.30 10.62 149 1212182 20022 109356946
Tongue haemorrhage 13.30 10.62 36 1212295 1169 109375799
Cytopenia 13.30 10.62 241 1212090 29875 109347093
Pelvic haematoma 13.29 10.62 33 1212298 1016 109375952
Subgaleal haematoma 13.28 10.62 11 1212320 114 109376854
Left ventricular dilatation 13.28 10.62 40 1212291 1382 109375586
Iridocele 13.27 10.62 6 1212325 17 109376951
Gastrointestinal pain 13.26 10.62 193 1212138 11667 109365301
Abdominal tenderness 13.26 10.62 201 1212130 12256 109364712
Optic discs blurred 13.25 10.62 9 1212322 67 109376901
Treatment noncompliance 13.24 10.62 950 1211381 72040 109304928
Factor V inhibition 13.21 10.62 19 1212312 382 109376586
Product impurity 13.20 10.62 10 1212321 90 109376878
General symptom 13.20 10.62 51 1212280 8795 109368173
Nasal obstruction 13.20 10.62 72 1212259 3278 109373690
Blood creatine phosphokinase abnormal 13.17 10.62 26 1212305 683 109376285
Enlarged uvula 13.13 10.62 21 1212310 465 109376503
Diabetic retinal oedema 13.13 10.62 20 1212311 424 109376544
Attention deficit hyperactivity disorder 13.12 10.62 18 1212313 4473 109372495
Metastases to peritoneum 13.12 10.62 26 1212305 5584 109371384
Graft haemorrhage 13.12 10.62 10 1212321 91 109376877
Retinal pigment epitheliopathy 13.10 10.62 22 1212309 508 109376460
Leukoencephalopathy 13.10 10.62 54 1212277 9141 109367827
Jejunal ulcer 13.09 10.62 15 1212316 238 109376730
Epididymitis 13.09 10.62 58 1212273 2426 109374542
Product preparation error 13.06 10.62 68 1212263 10811 109366157
Propofol infusion syndrome 13.06 10.62 6 1212325 2583 109374385
Medical device site thrombosis 13.05 10.62 11 1212320 117 109376851
Muscle enzyme increased 13.04 10.62 22 1212309 510 109376458
Hypoglycaemic unconsciousness 13.02 10.62 36 1212295 1184 109375784
Complication of device removal 13.02 10.62 19 1212312 4601 109372367
Normocytic anaemia 13.02 10.62 118 1212213 6349 109370619
Myelofibrosis 13.00 10.62 67 1212264 2984 109373984
Adrenal haemorrhage 12.99 10.62 28 1212303 784 109376184
Product storage error 12.99 10.62 164 1212167 21564 109355404
Pneumomediastinum 12.97 10.62 22 1212309 5014 109371954
Soft tissue haemorrhage 12.96 10.62 20 1212311 429 109376539
Methaemoglobinaemia 12.96 10.62 54 1212277 9114 109367854
Gastrooesophageal cancer 12.93 10.62 5 1212326 8 109376960
Systolic hypertension 12.93 10.62 31 1212300 933 109376035
Physical examination abnormal 12.92 10.62 22 1212309 514 109376454
Herbal interaction 12.91 10.62 24 1212307 602 109376366
Lung neoplasm malignant 12.90 10.62 473 1211858 33369 109343599
Small intestine polyp 12.89 10.62 8 1212323 50 109376918
Thromboangiitis obliterans 12.89 10.62 8 1212323 50 109376918
Psychotic symptom 12.88 10.62 14 1212317 3853 109373115
Normochromic normocytic anaemia 12.88 10.62 208 1212123 12849 109364119
Eyelid oedema 12.84 10.62 237 1212094 15025 109361943
Aorta hypoplasia 12.83 10.62 7 1212324 33 109376935
Relapsing-remitting multiple sclerosis 12.83 10.62 51 1212280 2031 109374937
Procedural hypotension 12.83 10.62 58 1212273 2447 109374521
Encephalopathy 12.82 10.62 742 1211589 80313 109296655
Cardioversion 12.82 10.62 55 1212276 2268 109374700
Adenocarcinoma pancreas 12.81 10.62 54 1212277 2209 109374759
Urine odour abnormal 12.80 10.62 131 1212200 7284 109369684
Ventricular enlargement 12.79 10.62 26 1212305 698 109376270
Bladder disorder 12.76 10.62 182 1212149 10955 109366013
Scrotal oedema 12.72 10.62 44 1212287 1637 109375331
Skin ulcer 12.71 10.62 835 1211496 62810 109314158
Hypothermia 12.69 10.62 378 1211953 25924 109351044
Neutropenic sepsis 12.66 10.62 249 1212082 30497 109346471
Conduction disorder 12.66 10.62 82 1212249 3973 109372995
Cardiotoxicity 12.65 10.62 121 1212210 16760 109360208
Shunt thrombosis 12.64 10.62 12 1212319 151 109376817
Cardiac fibrillation 12.63 10.62 33 1212298 1049 109375919
Mycobacterial infection 12.61 10.62 18 1212313 4399 109372569
Thyroid haemorrhage 12.60 10.62 10 1212321 97 109376871
Parvovirus B19 infection 12.60 10.62 8 1212323 2873 109374095
Burning sensation 12.58 10.62 901 1211430 68311 109308657
Urine output decreased 12.58 10.62 296 1212035 19580 109357388
Neurofibroma 12.57 10.62 6 1212325 20 109376948
Sinoatrial block 12.56 10.62 40 1212291 1425 109375543
Skin cancer 12.56 10.62 269 1212062 17515 109359453
Arteriovenous fistula occlusion 12.54 10.62 22 1212309 527 109376441
Wound infection pseudomonas 12.48 10.62 56 1212275 2355 109374613
Macular oedema 12.48 10.62 124 1212207 6842 109370126
Diffuse large B-cell lymphoma refractory 12.47 10.62 6 1212325 2515 109374453
Malignant spinal cord compression 12.45 10.62 12 1212319 154 109376814
Ventricular failure 12.42 10.62 22 1212309 531 109376437
Cholecystitis infective 12.41 10.62 76 1212255 3611 109373357
Jaundice hepatocellular 12.41 10.62 11 1212320 126 109376842
Moyamoya disease 12.41 10.62 11 1212320 126 109376842
Arterial insufficiency 12.40 10.62 18 1212313 365 109376603
Peritoneal haematoma 12.39 10.62 15 1212316 253 109376715
Human chorionic gonadotropin increased 12.39 10.62 41 1212290 1491 109375477
Injection site scab 12.38 10.62 24 1212307 622 109376346
Dermatitis atopic 12.37 10.62 201 1212130 25340 109351628
Daydreaming 12.37 10.62 35 1212296 1167 109375801
Lipodystrophy acquired 12.37 10.62 19 1212312 4505 109372463
Choroidal effusion 12.35 10.62 29 1212302 861 109376107
Epstein-Barr virus associated lymphoproliferative disorder 12.34 10.62 21 1212310 4781 109372187
Lumbar hernia 12.33 10.62 12 1212319 156 109376812
Ischaemic skin ulcer 12.33 10.62 13 1212318 187 109376781
Humerus fracture 12.30 10.62 176 1212155 10600 109366368
Urinary tract obstruction 12.29 10.62 98 1212233 5079 109371889
Breech presentation 12.28 10.62 26 1212305 719 109376249
Anaesthesia 12.26 10.62 23 1212308 581 109376387
Intestinal polyp 12.26 10.62 56 1212275 2373 109374595
Infected skin ulcer 12.25 10.62 80 1212251 3887 109373081
Bladder obstruction 12.25 10.62 22 1212309 537 109376431
Hemianaesthesia 12.25 10.62 20 1212311 451 109376517
Albumin urine 12.24 10.62 5 1212326 10 109376958
Puncture site reaction 12.24 10.62 5 1212326 10 109376958
Right atrial enlargement 12.20 10.62 21 1212310 495 109376473
Prostate cancer stage IV 12.19 10.62 6 1212325 2482 109374486
Pancreatic carcinoma 12.18 10.62 230 1212101 14642 109362326
Nephrogenic anaemia 12.18 10.62 89 1212242 4488 109372480
Tympanic membrane perforation 12.17 10.62 51 1212280 2081 109374887
Arterial repair 12.16 10.62 9 1212322 78 109376890
Symptom recurrence 12.15 10.62 21 1212310 4751 109372217
Blood pressure difference of extremities 12.14 10.62 6 1212325 22 109376946
Cerebral aspergillosis 12.14 10.62 5 1212326 2297 109374671
Fibrin D dimer increased 12.13 10.62 163 1212168 9682 109367286
Decreased immune responsiveness 12.13 10.62 59 1212272 9547 109367421
Consciousness fluctuating 12.12 10.62 52 1212279 2144 109374824
Rectal ulcer haemorrhage 12.11 10.62 17 1212314 334 109376634
Deafness unilateral 12.10 10.62 88 1212243 4431 109372537
Muscle relaxant therapy 12.09 10.62 12 1212319 160 109376808
Pregnancy with contraceptive device 12.09 10.62 15 1212316 3892 109373076
Stress 12.08 10.62 992 1211339 104356 109272612
Procedural pain 12.07 10.62 297 1212034 35268 109341700
Vasoplegia syndrome 12.05 10.62 26 1212305 5413 109371555
Hypereosinophilic syndrome 12.04 10.62 28 1212303 826 109376142
Systemic mastocytosis 12.03 10.62 17 1212314 336 109376632
Skin fissures 12.01 10.62 192 1212139 24266 109352702
Splenic injury 12.00 10.62 15 1212316 262 109376706
Stress ulcer 11.99 10.62 17 1212314 337 109376631
Respiratory rate increased 11.97 10.62 360 1211971 24723 109352245
Albuminuria 11.97 10.62 31 1212300 980 109375988
Carboxyhaemoglobin increased 11.95 10.62 8 1212323 58 109376910
Subcapsular hepatic haematoma 11.94 10.62 6 1212325 23 109376945
Haematoma evacuation 11.94 10.62 18 1212313 378 109376590
Anaphylactic shock 11.94 10.62 453 1211878 51093 109325875
Urine protein/creatinine ratio decreased 11.93 10.62 5 1212326 11 109376957
Congenital heart valve disorder 11.92 10.62 7 1212324 39 109376929
Prothrombin time abnormal 11.92 10.62 36 1212295 1246 109375722
Collagen disorder 11.91 10.62 16 1212315 301 109376667
Lung infiltration 11.90 10.62 354 1211977 24274 109352694
Pulmonary venous hypertension 11.89 10.62 4 1212327 3 109376965
Gastric occult blood positive 11.89 10.62 4 1212327 3 109376965
Vessel puncture site swelling 11.89 10.62 4 1212327 3 109376965
Electrocardiogram 11.89 10.62 4 1212327 3 109376965
Homocystinaemia 11.89 10.62 4 1212327 3 109376965
Epstein-Barr viraemia 11.88 10.62 13 1212318 3566 109373402
Femoral hernia incarcerated 11.86 10.62 40 1212291 1469 109375499
Hepatic haematoma 11.85 10.62 30 1212301 935 109376033
Hypertonic bladder 11.85 10.62 99 1212232 5203 109371765
Cardiorenal syndrome 11.83 10.62 47 1212284 1871 109375097
Labelled drug-food interaction medication error 11.81 10.62 13 1212318 197 109376771
Bundle branch block 11.79 10.62 45 1212286 1758 109375210
Acute respiratory distress syndrome 11.78 10.62 470 1211861 52728 109324240
Capillaritis 11.77 10.62 6 1212325 2433 109374535
Diabetic gastroparesis 11.77 10.62 18 1212313 383 109376585
Photophobia 11.77 10.62 205 1212126 25566 109351402
Sodium retention 11.76 10.62 14 1212317 232 109376736
Hypervitaminosis D 11.74 10.62 11 1212320 136 109376832
Optic disc haemorrhage 11.71 10.62 14 1212317 233 109376735
Cataract nuclear 11.70 10.62 38 1212293 1368 109375600
Mitral valve replacement 11.68 10.62 23 1212308 603 109376365
Mucosal discolouration 11.67 10.62 30 1212301 944 109376024
Pleural thickening 11.67 10.62 12 1212319 3387 109373581
Intrapericardial thrombosis 11.63 10.62 8 1212323 61 109376907
Electrocardiogram Q waves 11.62 10.62 9 1212322 84 109376884
Laryngeal ulceration 11.61 10.62 11 1212320 138 109376830
Neutrophil count increased 11.59 10.62 290 1212041 34362 109342606
Myocardial bridging 11.57 10.62 6 1212325 25 109376943
Ultrasound Doppler abnormal 11.55 10.62 11 1212320 139 109376829
Unmasking of previously unidentified disease 11.54 10.62 62 1212269 2806 109374162
Myasthenia gravis 11.54 10.62 166 1212165 21345 109355623
Laryngeal oedema 11.53 10.62 161 1212170 9646 109367322
Pancreatic steatosis 11.53 10.62 45 1212286 1777 109375191
Aortic thrombosis 11.52 10.62 51 1212280 2132 109374836
Electrocardiogram QT prolonged 11.51 10.62 1364 1210967 107596 109269372
Haemoglobin increased 11.50 10.62 152 1212179 8995 109367973
Encephalitis autoimmune 11.50 10.62 13 1212318 3515 109373453
Gastroenteritis 11.50 10.62 528 1211803 38272 109338696
Nasal polyps 11.50 10.62 91 1212240 13109 109363859
Renal haematoma 11.49 10.62 30 1212301 953 109376015
Bladder diverticulum 11.49 10.62 11 1212320 140 109376828
Gallbladder disorder 11.48 10.62 307 1212024 20722 109356246
Autoimmune hepatitis 11.47 10.62 227 1212104 14577 109362391
Nail discomfort 11.45 10.62 9 1212322 86 109376882
Musculoskeletal chest pain 11.44 10.62 405 1211926 28442 109348526
Productive cough 11.43 10.62 1426 1210905 112879 109264089
Myelitis 11.42 10.62 11 1212320 3202 109373766
Hepatic infiltration eosinophilic 11.39 10.62 6 1212325 26 109376942
Iliac vein occlusion 11.39 10.62 6 1212325 26 109376942
Urethral stenosis 11.37 10.62 34 1212297 1170 109375798
Anti-SRP antibody positive 11.37 10.62 4 1212327 4 109376964
Metabolic disorder 11.36 10.62 68 1212263 10442 109366526
Peripheral artery angioplasty 11.36 10.62 5 1212326 13 109376955
Blood urea abnormal 11.36 10.62 46 1212285 1848 109375120
Right ventricular hypertrophy 11.32 10.62 43 1212288 1676 109375292
Helicobacter test false negative 11.32 10.62 8 1212323 64 109376904
Vertebral artery occlusion 11.31 10.62 20 1212311 482 109376486
Accidental exposure to product by child 11.31 10.62 11 1212320 3187 109373781
Rectal tenesmus 11.30 10.62 52 1212279 2210 109374758
Meniscus injury 11.30 10.62 133 1212198 7660 109369308
Mycobacterium test positive 11.30 10.62 23 1212308 618 109376350
Acquired oesophageal web 11.29 10.62 16 1212315 317 109376651
Depressed level of consciousness 11.27 10.62 1401 1210930 110877 109266091
Cardiolipin antibody positive 11.26 10.62 12 1212319 175 109376793
Scrotal swelling 11.25 10.62 34 1212297 1177 109375791
Gynaecomastia 11.24 10.62 156 1212175 9334 109367634
Cardioactive drug level increased 11.22 10.62 77 1212254 3805 109373163
Bladder adenocarcinoma stage unspecified 11.21 10.62 6 1212325 27 109376941
Pulmonary contusion 11.20 10.62 12 1212319 176 109376792
Lymphatic fistula 11.20 10.62 39 1212292 1456 109375512
Faecal calprotectin increased 11.18 10.62 37 1212294 6682 109370286
Hypoosmolar state 11.18 10.62 18 1212313 401 109376567
Patent ductus arteriosus 11.15 10.62 12 1212319 177 109376791
Total cholesterol/HDL ratio increased 11.15 10.62 18 1212313 402 109376566
Encephalitis toxic 11.13 10.62 15 1212316 283 109376685
Hyperthermia 11.12 10.62 165 1212166 21107 109355861
Retinal vein thrombosis 11.11 10.62 25 1212306 721 109376247
Duodenal vascular ectasia 11.10 10.62 5 1212326 14 109376954
Human polyomavirus infection 11.10 10.62 3 1212328 1799 109375169
Choking sensation 11.10 10.62 85 1212246 4351 109372617
Obstruction 11.10 10.62 104 1212227 5648 109371320
Peripheral embolism 11.09 10.62 48 1212283 1987 109374981
Sudden death 11.08 10.62 348 1211983 24047 109352921
Haemostasis 11.07 10.62 21 1212310 535 109376433
Cardiac flutter 11.06 10.62 104 1212227 5653 109371315
Mesenteric artery thrombosis 11.06 10.62 29 1212302 924 109376044
Supravalvular aortic stenosis 11.05 10.62 6 1212325 28 109376940
Type IIa hyperlipidaemia 11.03 10.62 20 1212311 492 109376476
Menstruation delayed 11.03 10.62 3 1212328 1791 109375177
Atrial conduction time prolongation 11.02 10.62 8 1212323 67 109376901
Coarctation of the aorta 11.02 10.62 8 1212323 67 109376901
Radiation overdose 11.02 10.62 8 1212323 67 109376901
Bronchoscopy abnormal 11.02 10.62 8 1212323 67 109376901
Blood bicarbonate abnormal 11.01 10.62 11 1212320 148 109376820
Paresis cranial nerve 11.00 10.62 7 1212324 46 109376922
Platelet aggregation decreased 11.00 10.62 7 1212324 46 109376922
Blepharal pigmentation 11.00 10.62 7 1212324 46 109376922
Cholelithiasis obstructive 11.00 10.62 7 1212324 46 109376922
Abdominal distension 10.99 10.62 1718 1210613 173385 109203583
Volume blood decreased 10.99 10.62 18 1212313 407 109376561
Bone cyst 10.98 10.62 14 1212317 3589 109373379
Salivary gland enlargement 10.98 10.62 19 1212312 450 109376518
Prosthetic cardiac valve thrombosis 10.97 10.62 9 1212322 92 109376876
Twin pregnancy 10.96 10.62 29 1212302 929 109376039
Albumin urine present 10.96 10.62 25 1212306 728 109376240
Emphysema 10.95 10.62 289 1212042 19467 109357501
Traumatic liver injury 10.93 10.62 23 1212308 633 109376335
Diplopia 10.93 10.62 563 1211768 41331 109335637
Prostate cancer stage III 10.91 10.62 3 1212328 1779 109375189
Intestinal stenosis 10.90 10.62 22 1212309 4693 109372275
Immune-mediated adrenal insuficiency 10.90 10.62 3 1212328 1777 109375191
Rash erythematous 10.89 10.62 761 1211570 81071 109295897
Biopsy site unspecified abnormal 10.88 10.62 6 1212325 29 109376939
Colon neoplasm 10.88 10.62 29 1212302 933 109376035
Coronary no-reflow phenomenon 10.85 10.62 5 1212326 15 109376953
Epididymal cyst 10.85 10.62 5 1212326 15 109376953
Stent malfunction 10.84 10.62 8 1212323 69 109376899
Blood blister 10.83 10.62 76 1212255 3783 109373185
Eosinophil count decreased 10.82 10.62 32 1212299 5986 109370982
Neoplasm malignant 10.82 10.62 317 1212014 36826 109340142
Anal inflammation 10.82 10.62 7 1212324 2489 109374479
Social avoidant behaviour 10.82 10.62 27 1212304 5342 109371626
Premature separation of placenta 10.80 10.62 40 1212291 1540 109375428
Aldolase increased 10.80 10.62 13 1212318 218 109376750
Eosinophilic pneumonia chronic 10.78 10.62 21 1212310 546 109376422
Bicuspid aortic valve 10.77 10.62 7 1212324 48 109376920
Hypochromasia 10.76 10.62 24 1212307 688 109376280
Pulmonary mucormycosis 10.76 10.62 5 1212326 2138 109374830
Parotid gland haemorrhage 10.72 10.62 6 1212325 30 109376938
Mitral valve hypoplasia 10.72 10.62 6 1212325 30 109376938
Blood sodium increased 10.72 10.62 100 1212231 5423 109371545
Shone complex 10.72 10.62 6 1212325 30 109376938
Polycythaemia 10.70 10.62 67 1212264 3208 109373760
Squamous cell carcinoma of lung 10.67 10.62 59 1212272 2700 109374268
Superficial siderosis of central nervous system 10.67 10.62 11 1212320 154 109376814
Accident at home 10.66 10.62 13 1212318 221 109376747
Vasodilatation 10.66 10.62 74 1212257 3670 109373298
Diabetic microangiopathy 10.65 10.62 7 1212324 49 109376919
Blood cholesterol abnormal 10.64 10.62 74 1212257 3672 109373296
Wound necrosis 10.63 10.62 25 1212306 743 109376225
Hysterosalpingo-oophorectomy 10.62 10.62 5 1212326 16 109376952

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gene mutation 29.42 27.59 15 1019 76 112843

Pharmacologic Action:

SourceCodeDescription
ATC A01AD05 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Other agents for local oral treatment
ATC B01AC06 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC B01AC56 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC B01AF51 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Direct factor Xa inhibitors
ATC C07FX02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX04 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C10BX01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC M01BA03 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY/ANTIRHEUMATIC AGENTS IN COMBINATION
Antiinflammatory/antirheumatic agents in combination with corticosteroids
ATC N02AJ02 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ07 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ18 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02BA01 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA51 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA71 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
FDA PE N0000008832 Decreased Platelet Aggregation
FDA PE N0000008836 Decreased Prostaglandin Production
FDA EPC N0000175578 Platelet Aggregation Inhibitor
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D058633 Antipyretics
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35493 antipyretic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:49023 prostaglandin antagonist
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:50427 platelet aggregation inhibitor
CHEBI has role CHEBI:50629 cyclooxygenase 2 inhibitor
CHEBI has role CHEBI:50630 cyclooxygenase 1 inhibitor
CHEBI has role CHEBI:50905 teratogenic agent
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73182 plant activator
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77425 EC 1.1.1.188 (prostaglandin-F synthase) inhibitor
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:176497 geroprotector

Related Drugs by ATC class:

A01AD Other agents for local oral treatment 5 drugs
adrenaloneamlexanoxbecaplerminbenzydamineepinephrine
B01AC Platelet aggregation inhibitors excl. heparin 24 drugs
abciximabaloxiprinberaprostcangrelorcarbasalate calciumcilostazolclopidogrelcloricromendipyridamoleditazoleepoprostenoleptifibatide show all 24 →
B01AF Direct factor Xa inhibitors 4 drugs
apixabanbetrixabanedoxabanrivaroxaban
C07FX Beta blocking agents, other combinations 6 drugs
bisoprololcarvedilolivabradinemetoprololpropranololsotalol
C10BX Lipid modifying agents in combination with other drugs 14 drugs
amlodipineatorvastatincandesartan cilexetilfimasartanindapamidelisinoprilnebivololperindoprilpravastatinramiprilrosuvastatinsimvastatin show all 14 →
M01BA Antiinflammatory/antirheumatic agents in combination with corticosteroids 2 drugs
dipyrocetylphenylbutazone
N02AJ Opioids in combination with non-opioid analgesics 9 drugs
celecoxibcodeinedexketoprofendihydrocodeinehydrocodoneibuprofenoxycodoneparacetamoltramadol
N02BA Salicylic acid and derivatives 11 drugs
aloxiprinbenorilatecarbasalate calciumdiflunisaldipyrocetylethenzamideguacetisalmagnesium salicylatesalicylamidesalicylic acidsalsalate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Pain indication 22253000
Myocardial infarction indication 22298006 DOID:5844
Toothache indication 27355003
Migraine indication 37796009 DOID:6364
Joint pain indication 57676002
Rheumatoid arthritis indication 69896004 DOID:7148
Common cold indication 82272006 DOID:10459
Backache indication 161891005
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Osteoarthritis indication 396275006
Arthritic Pain indication




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Pain Indication
Dogs Inflammation Indication

🐶 Veterinary products

ProductApplicantIngredients
Cortaba Tablets Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.57 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 10786444 Sept. 29, 2032 A METHOD OF TARGETING RELEASE OF A NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) TO THE SMALL INTESTINE OF THE SUBJECT WHEN ADMINISTERED ORALLY
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TEMPORARY REDUCTION OF FEVER
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TEMPORARY RELIEF OF MINOR ACHES AND PAINS
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TREATMENT/PREVENTION OF CARDIOVASCULAR DISEASE
81MG VAZALORE PLX PHARMA N203697 Feb. 26, 2021 OTC CAPSULE ORAL 10786444 Sept. 29, 2032 A METHOD OF TARGETING RELEASE OF A NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) TO THE SMALL INTESTINE OF THE SUBJECT WHEN ADMINISTERED ORALLY
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5.12 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.77 WOMBAT-PK CHEMBL
Gamma-glutamyltranspeptidase 1 Enzyme IC50 4.44 CHEMBL
Acid-sensing ion channel 3 Ion channel BLOCKER IC50 4 IUPHAR
High mobility group protein B1 Nuclear other Kd 6 CHEMBL
Nicotinate phosphoribosyltransferase Enzyme Ki 9.30 CHEMBL
Acidic phospholipase A2 3 Enzyme Kd 5.20 WOMBAT-PK
Prostaglandin G/H synthase 1 Enzyme IC50 6.52 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.62 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.46 CHEMBL

External reference:

IDSource
4017536 VUID
N0000145918 NUI
D00109 KEGG_DRUG
1191 RXNORM
C0004057 UMLSCUI
CHEBI:15365 CHEBI
AIN PDB_CHEM_ID
CHEMBL25 ChEMBL_ID
DB00945 DRUGBANK_ID
2244 PUBCHEM_CID
493-53-8 SECONDARY_CAS_RN
244 MMSL
34512 MMSL
4223 MMSL
d00170 MMSL
D001241 MESH_DESCRIPTOR_UI
CHEMBL1697753 ChEMBL_ID
132-49-0 SECONDARY_CAS_RN
25817-25-8 SECONDARY_CAS_RN
69-46-5 SECONDARY_CAS_RN
1466-82-6 SECONDARY_CAS_RN
37933-78-1 SECONDARY_CAS_RN
4139 IUPHAR_LIGAND_ID
4017536 VANDF
R16CO5Y76E UNII
001587 NDDF
387458008 SNOMEDCT_US
7947003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 13 sections
Excedrin Extra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 15 sections
Excedrin Extra Strength Headache HUMAN OTC DRUG LABEL 3 0067-2002 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 15 sections
Excedrin Extra Strength Headache HUMAN OTC DRUG LABEL 3 0067-2003 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 15 sections
ExcedrinExtra Strength Geltabs HUMAN OTC DRUG LABEL 3 0067-2021 TABLET, COATED 250 mg ORAL OTC Monograph Drug 14 sections
Excedrin Migraine Geltabs HUMAN OTC DRUG LABEL 3 0067-2035 TABLET, COATED 250 mg ORAL NDA 14 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
ExcedrinMigraine HUMAN OTC DRUG LABEL 3 0067-2040 TABLET, FILM COATED 250 mg ORAL NDA 16 sections
ExcedrinMigraine Relief HUMAN OTC DRUG LABEL 3 0067-2042 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
Excedrin PM Triple Action Caplets HUMAN OTC DRUG LABEL 3 0067-2056 TABLET, COATED 250 mg ORAL OTC Monograph Drug 16 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-8201 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8202 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 15 sections
Excedrin Extra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8203 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 15 sections
Good Sense aspirin HUMAN OTC DRUG LABEL 1 0113-0274 TABLET, CHEWABLE 81 mg ORAL OTC Monograph Drug 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-0374 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0467 TABLET, CHEWABLE 81 mg ORAL OTC Monograph Drug 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-1619 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-1619 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
good sense headache relief HUMAN OTC DRUG LABEL 3 0113-1855 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 15 sections
Alka-Seltzer Plus Severe Cold PowerFast FizzOrange Zest HUMAN OTC DRUG LABEL 3 0280-0020 TABLET, EFFERVESCENT 325 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Plus Severe Cold Powerfast Fizz Night HUMAN OTC DRUG LABEL 4 0280-0021 TABLET, EFFERVESCENT 500 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0023 TABLET, EFFERVESCENT 325 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Plus Severe Cold PowerFast Fizz Non Drowsy HUMAN OTC DRUG LABEL 3 0280-0024 TABLET, EFFERVESCENT 325 mg ORAL OTC Monograph Drug 16 sections
BAYER 500 mg HUMAN OTC DRUG LABEL 1 0280-0029 POWDER 500 mg ORAL Export only 2 sections
Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz HUMAN OTC DRUG LABEL 3 0280-0060 TABLET, EFFERVESCENT 325 mg ORAL OTC Monograph Drug 15 sections
Bayer Headache HUMAN OTC DRUG LABEL 2 0280-0064 TABLET 500 mg ORAL OTC Monograph Drug 14 sections
Alka-Seltzer Plus Severe Cold Night PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0068 TABLET, EFFERVESCENT 325 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Hangover Relief HUMAN OTC DRUG LABEL 2 0280-0084 TABLET, EFFERVESCENT 500 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Hangover Relief HUMAN OTC DRUG LABEL 2 0280-0084 TABLET, EFFERVESCENT 500 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Original Flavor HUMAN OTC DRUG LABEL 1 0280-0087 TABLET, EFFERVESCENT 325 mg ORAL OTC Monograph Drug 15 sections