acetylsalicylic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
74 50-78-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetylsalisylic acid
  • aspirin
  • acetylsalicylic acid
  • aspirin sodium
  • aspirin magnesium
  • aspirin potassium
  • aspirin calcium
  • aspirin anhydride
  • aspirin lysine
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
  • Molecular weight: 180.16
  • Formula: C9H8O4
  • CLOGP: 1.02
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -2.09
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 tablet O
30 mg O
3 g O
1 g P
3 g R

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 370.22 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.40 % Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution) 0.22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.68 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.26 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 12, 1950 FDA ENDO PHARMS
Jan. 1, 1898 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 9982.15 27.42 2684 18310 18350 2318741
Toxicity to various agents 9876.37 27.42 2928 18066 29826 2307265
Overdose 3393.04 27.42 1165 19829 18742 2318349
Gastrointestinal haemorrhage 2770.44 27.42 892 20102 11543 2325548
Drug hypersensitivity 2246.77 27.42 1104 19890 45539 2291552
Intentional overdose 2120.33 27.42 713 20281 10608 2326483
Intentional product misuse 1769.17 27.42 596 20398 8893 2328198
Death 1620.49 27.42 1083 19911 80385 2256706
Anaemia 1468.55 27.42 755 20239 34037 2303054
Acute hepatic failure 1379.63 27.42 368 20626 2274 2334817
Cardiac arrest 1311.78 27.42 540 20454 14390 2322701
Metabolic acidosis 1201.04 27.42 398 20596 5600 2331491
Melaena 1189.05 27.42 361 20633 3745 2333346
Hypotension 1183.08 27.42 639 20355 31797 2305294
Vomiting 1150.81 27.42 837 20157 70765 2266326
Suicide attempt 1065.29 27.42 430 20564 10852 2326239
Haemoglobin decreased 999.34 27.42 473 20521 17678 2319413
Cardio-respiratory arrest 962.18 27.42 377 20617 8769 2328322
Haematemesis 951.20 27.42 304 20690 3778 2333313
Respiratory arrest 928.98 27.42 331 20663 5847 2331244
Coma 919.99 27.42 364 20630 8692 2328399
International normalised ratio increased 891.65 27.42 336 20658 7000 2330091
Acute kidney injury 846.72 27.42 489 20505 27633 2309458
Drug abuse 839.71 27.42 370 20624 11656 2325435
Upper gastrointestinal haemorrhage 836.77 27.42 236 20758 1838 2335253
Hepatic failure 829.56 27.42 298 20696 5391 2331700
Coagulopathy 812.92 27.42 249 20745 2660 2334431
Nausea 797.42 27.42 823 20171 111366 2225725
Cerebral haemorrhage 778.83 27.42 282 20712 5222 2331869
Rectal haemorrhage 754.41 27.42 280 20714 5576 2331515
Gastric ulcer 724.63 27.42 230 20764 2786 2334305
Aspirin-exacerbated respiratory disease 713.88 27.42 134 20860 62 2337029
Haematoma 708.17 27.42 258 20736 4863 2332228
Hepatotoxicity 692.21 27.42 230 20764 3251 2333840
Exposure during pregnancy 688.86 27.42 412 20582 24807 2312284
Poisoning 668.97 27.42 213 20781 2607 2334484
Maternal exposure during pregnancy 631.48 27.42 325 20669 14538 2322553
Haemorrhage 616.85 27.42 291 20703 10748 2326343
Angioedema 604.04 27.42 264 20730 8132 2328959
Alanine aminotransferase increased 587.88 27.42 304 20690 13728 2323363
Drug interaction 537.35 27.42 372 20622 28791 2308300
Depressed level of consciousness 530.40 27.42 234 20760 7370 2329721
Tachycardia 529.58 27.42 299 20695 16110 2320981
Drug ineffective 529.39 27.42 635 20359 100989 2236102
Aspartate aminotransferase increased 527.52 27.42 273 20721 12339 2324752
Haematochezia 513.41 27.42 206 20788 5089 2332002
Headache 501.43 27.42 551 20443 79628 2257463
Liver injury 496.51 27.42 162 20832 2152 2334939
Medication error 494.20 27.42 209 20785 5922 2331169
Dizziness 493.18 27.42 473 20521 58192 2278899
Epistaxis 489.13 27.42 239 20755 9540 2327551
Somnolence 481.08 27.42 320 20674 23165 2313926
Duodenal ulcer 461.68 27.42 130 20864 1003 2336088
Toxic epidermal necrolysis 455.37 27.42 164 20830 2980 2334111
Accidental overdose 453.57 27.42 174 20820 3798 2333293
Confusional state 451.65 27.42 312 20682 24032 2313059
Dyspnoea 447.50 27.42 515 20479 78218 2258873
Abdominal pain 430.68 27.42 348 20646 34026 2303065
Pharyngitis 429.54 27.42 144 20850 2091 2335000
Premature delivery 397.16 27.42 149 20845 3051 2334040
Haemorrhage intracranial 397.10 27.42 141 20853 2453 2334638
Deafness transitory 390.40 27.42 80 20914 103 2336988
Labelled drug-drug interaction medication error 369.59 27.42 113 20881 1195 2335896
Decreased appetite 364.88 27.42 294 20700 28597 2308494
Abdominal pain upper 362.88 27.42 263 20731 21837 2315254
Gastritis erosive 354.96 27.42 99 20895 734 2336357
Fall 352.87 27.42 357 20637 46742 2290349
Hepatic necrosis 339.79 27.42 102 20892 1008 2336083
Urticaria 338.78 27.42 262 20732 23999 2313092
Multiple organ dysfunction syndrome 338.35 27.42 172 20822 7469 2329622
Ear infection 337.34 27.42 135 20859 3306 2333785
Stevens-Johnson syndrome 335.84 27.42 143 20851 4116 2332975
Subdural haematoma 332.11 27.42 119 20875 2127 2334964
Gastrointestinal pain 322.94 27.42 98 20896 1008 2336083
Thrombocytopenia 312.45 27.42 227 20767 18904 2318187
Exposure via ingestion 310.08 27.42 88 20906 700 2336391
Renal failure 308.94 27.42 217 20777 17132 2319959
Prothrombin time prolonged 302.31 27.42 103 20891 1574 2335517
Gastritis 296.92 27.42 134 20860 4447 2332644
Blood loss anaemia 294.29 27.42 92 20902 1053 2336038
Faeces discoloured 282.38 27.42 107 20887 2252 2334839
Hypophagia 281.64 27.42 124 20870 3876 2333215
Product administration error 280.11 27.42 123 20871 3820 2333271
Lower gastrointestinal haemorrhage 270.39 27.42 84 20910 940 2336151
Weight decreased 268.85 27.42 245 20749 28126 2308965
Cerebrovascular accident 268.69 27.42 212 20782 19974 2317117
Asthenia 267.47 27.42 308 20686 46618 2290473
Loss of consciousness 264.74 27.42 204 20790 18563 2318528
Anion gap 264.50 27.42 55 20939 80 2337011
Syncope 261.41 27.42 194 20800 16681 2320410
Atrial fibrillation 260.97 27.42 179 20815 13589 2323502
Pyrexia 257.78 27.42 323 20671 53385 2283706
Acidosis 255.83 27.42 90 20904 1520 2335571
Brain oedema 255.79 27.42 99 20895 2211 2334880
Product use in unapproved indication 254.35 27.42 163 20831 11037 2326054
Haematocrit decreased 253.74 27.42 118 20876 4200 2332891
Hepatitis 252.73 27.42 133 20861 6204 2330887
Gastric ulcer haemorrhage 247.67 27.42 75 20919 765 2336326
Abdominal discomfort 246.75 27.42 190 20804 17266 2319825
Subarachnoid haemorrhage 243.24 27.42 93 20901 2007 2335084
Acute myocardial infarction 241.97 27.42 120 20874 4935 2332156
Contraindicated product administered 240.00 27.42 102 20892 2919 2334172
Encephalopathy 238.46 27.42 115 20879 4446 2332645
Shock haemorrhagic 235.95 27.42 80 20914 1203 2335888
Drug-induced liver injury 235.88 27.42 107 20887 3592 2333499
Haematuria 232.20 27.42 111 20883 4207 2332884
Agitation 231.73 27.42 153 20841 10898 2326193
Deafness 230.63 27.42 96 20898 2605 2334486
Shoulder arthroplasty 229.81 27.42 60 20934 334 2336757
Hypertension 222.26 27.42 217 20777 27144 2309947
Hypoglycaemia 220.23 27.42 134 20860 8273 2328818
Retroperitoneal haematoma 219.83 27.42 60 20934 406 2336685
Bradycardia 216.12 27.42 141 20853 9840 2327251
Haemoptysis 212.25 27.42 98 20896 3429 2333662
Respiratory depression 212.17 27.42 85 20909 2085 2335006
Hyperkalaemia 210.62 27.42 115 20879 5778 2331313
Lethargy 210.52 27.42 132 20862 8598 2328493
Hemiplegia 209.78 27.42 75 20919 1330 2335761
Myocardial infarction 209.58 27.42 179 20815 18834 2318257
Ulcer 206.11 27.42 80 20914 1800 2335291
Condition aggravated 204.43 27.42 223 20771 31756 2305335
Extradural haematoma 200.06 27.42 51 20943 254 2336837
Premature baby 198.98 27.42 91 20903 3113 2333978
Hiatus hernia 198.12 27.42 80 20914 2004 2335087
Hemiparesis 195.63 27.42 92 20902 3358 2333733
Vascular stent thrombosis 191.62 27.42 45 20949 147 2336944
Mental status changes 191.41 27.42 106 20888 5476 2331615
Blood bilirubin increased 190.16 27.42 104 20890 5241 2331850
Cardiac failure 189.37 27.42 140 20854 11954 2325137
Blood creatinine increased 187.94 27.42 132 20862 10401 2326690
Rash 186.62 27.42 292 20702 59266 2277825
Contusion 186.59 27.42 142 20852 12668 2324423
Asthma 186.26 27.42 135 20859 11179 2325912
Foetal exposure during pregnancy 183.56 27.42 101 20893 5151 2331940
Chest pain 181.17 27.42 197 20797 27940 2309151
Pain 181.07 27.42 294 20700 61563 2275528
Hepatic function abnormal 180.11 27.42 105 20889 5987 2331104
Pyroglutamate increased 179.69 27.42 35 20959 27 2337064
Dysarthria 179.43 27.42 106 20888 6196 2330895
Off label use 178.87 27.42 322 20672 73276 2263815
Dysphagia 177.87 27.42 138 20856 12667 2324424
Renal impairment 176.63 27.42 125 20869 9967 2327124
Unresponsive to stimuli 176.58 27.42 96 20898 4780 2332311
Pruritus 175.61 27.42 240 20754 43100 2293991
Seizure 174.69 27.42 181 20813 24285 2312806
Pulmonary oedema 174.17 27.42 110 20884 7253 2329838
Rhabdomyolysis 173.36 27.42 106 20888 6598 2330493
Ischaemic stroke 172.57 27.42 84 20910 3313 2333778
Anaphylactic reaction 171.69 27.42 121 20873 9584 2327507
Substance abuse 170.38 27.42 51 20943 498 2336593
Dyspepsia 170.14 27.42 121 20873 9723 2327368
Anuria 169.88 27.42 69 20925 1755 2335336
Transient ischaemic attack 168.75 27.42 100 20894 5878 2331213
Drug screen positive 163.81 27.42 56 20938 864 2336227
Fatigue 162.91 27.42 336 20658 84537 2252554
Activated partial thromboplastin time prolonged 159.97 27.42 60 20934 1225 2335866
Vascular pseudoaneurysm 159.48 27.42 42 20952 243 2336848
Respiratory failure 156.49 27.42 131 20863 13397 2323694
Diarrhoea 155.89 27.42 327 20667 83237 2253854
Retroperitoneal haemorrhage 154.40 27.42 48 20946 538 2336553
Hepatic encephalopathy 153.82 27.42 62 20932 1545 2335546
Analgesic drug level increased 153.72 27.42 41 20953 251 2336840
Sinus tachycardia 153.38 27.42 77 20917 3248 2333843
Tinnitus 153.10 27.42 89 20905 5046 2332045
Gastric haemorrhage 151.64 27.42 55 20939 1018 2336073
Premature labour 150.51 27.42 66 20928 2040 2335051
Poisoning deliberate 149.68 27.42 56 20938 1135 2335956
General physical health deterioration 149.42 27.42 130 20864 14009 2323082
Arterial haemorrhage 149.03 27.42 37 20957 162 2336929
Transaminases increased 148.79 27.42 84 20910 4503 2332588
Angina pectoris 148.55 27.42 80 20914 3907 2333184
Rheumatoid arthritis 148.25 27.42 148 20846 18992 2318099
Colitis microscopic 147.45 27.42 52 20942 884 2336207
Nasal disorder 147.42 27.42 41 20953 300 2336791
Hyponatraemia 145.85 27.42 125 20869 13200 2323891
Gastrointestinal disorder 145.83 27.42 106 20888 8811 2328280
Acute respiratory distress syndrome 145.32 27.42 74 20920 3218 2333873
Liver function test abnormal 143.29 27.42 98 20896 7392 2329699
Cardiogenic shock 142.98 27.42 67 20927 2424 2334667
Blood pH decreased 141.15 27.42 43 20951 448 2336643
Hepatic enzyme increased 139.07 27.42 107 20887 9695 2327396
Drug level increased 138.81 27.42 68 20926 2719 2334372
Pneumonia 136.96 27.42 229 20765 49067 2288024
Hypothermia 136.49 27.42 62 20932 2086 2335005
Drug intolerance 134.73 27.42 121 20873 13596 2323495
Respiratory alkalosis 132.90 27.42 38 20956 311 2336780
Peripheral swelling 132.46 27.42 134 20860 17463 2319628
Eye disorder 132.39 27.42 69 20925 3150 2333941
Mucosal erosion 132.25 27.42 35 20959 207 2336884
Urinary retention 132.21 27.42 72 20922 3595 2333496
Diverticulum intestinal 131.20 27.42 44 20950 638 2336453
Leukocytosis 131.12 27.42 71 20923 3505 2333586
Oesophagitis 130.94 27.42 59 20935 1947 2335144
Liver transplant 129.51 27.42 42 20952 545 2336546
Heart rate increased 129.37 27.42 108 20886 10997 2326094
Abdominal wall haematoma 129.18 27.42 40 20954 442 2336649
Feeding disorder 128.43 27.42 53 20941 1405 2335686
Thrombosis 127.93 27.42 99 20895 9045 2328046
Erythema 127.92 27.42 156 20838 25003 2312088
Pericardial haemorrhage 127.91 27.42 37 20957 317 2336774
Foetal death 127.24 27.42 57 20937 1855 2335236
Post procedural haemorrhage 126.25 27.42 51 20943 1278 2335813
Muscle spasticity 125.29 27.42 54 20940 1599 2335492
Shock 123.62 27.42 71 20923 3933 2333158
Oedema peripheral 123.50 27.42 149 20845 23614 2313477
Brain death 122.58 27.42 40 20954 530 2336561
Tachypnoea 121.93 27.42 58 20936 2171 2334920
Hyperhidrosis 120.78 27.42 120 20874 15302 2321789
Lower respiratory tract infection 120.73 27.42 78 20916 5346 2331745
Acute lung injury 120.51 27.42 31 20963 161 2336930
Pallor 119.94 27.42 68 20926 3674 2333417
Foot operation 119.25 27.42 42 20952 711 2336380
Platelet count decreased 118.25 27.42 120 20874 15693 2321398
Duodenal ulcer haemorrhage 117.91 27.42 36 20958 378 2336713
Lymphatic fistula 117.89 27.42 21 20973 2 2337089
Jaundice 117.19 27.42 77 20917 5431 2331660
Peritonitis 116.93 27.42 59 20935 2515 2334576
Haemarthrosis 116.90 27.42 36 20958 390 2336701
Intentional self-injury 116.36 27.42 69 20925 4058 2333033
Blood pressure decreased 116.33 27.42 94 20900 9142 2327949
Cough 115.72 27.42 171 20823 32946 2304145
Diverticulum intestinal haemorrhagic 115.10 27.42 31 20963 198 2336893
Circulatory collapse 114.94 27.42 66 20928 3654 2333437
Abortion spontaneous 113.47 27.42 109 20885 13336 2323755
Femoral hernia incarcerated 113.03 27.42 21 20973 8 2337083
Occult blood positive 112.71 27.42 37 20957 500 2336591
Gait disturbance 111.69 27.42 138 20856 22407 2314684
Hepatocellular injury 109.66 27.42 66 20928 3989 2333102
Cerebral infarction 109.21 27.42 68 20926 4369 2332722
Incorrect dose administered 108.21 27.42 92 20902 9603 2327488
Urinary tract infection 108.06 27.42 157 20837 29785 2307306
Arteriosclerosis coronary artery 107.95 27.42 44 20950 1129 2335962
Duodenal ulcer perforation 107.77 27.42 32 20962 303 2336788
Asphyxia 107.48 27.42 42 20952 962 2336129
Live birth 107.21 27.42 45 20949 1246 2335845
Dehydration 106.49 27.42 134 20860 22161 2314930
Blood urea increased 106.17 27.42 62 20932 3543 2333548
Respiratory distress 104.99 27.42 70 20924 5059 2332032
Lactic acidosis 104.93 27.42 71 20923 5259 2331832
Gamma-glutamyltransferase increased 104.54 27.42 72 20922 5490 2331601
Mydriasis 104.14 27.42 52 20942 2167 2334924
Swelling face 103.74 27.42 89 20905 9404 2327687
Product use issue 103.34 27.42 99 20895 12070 2325021
Respiratory disorder 102.70 27.42 63 20931 3941 2333150
Muscle haemorrhage 102.56 27.42 36 20958 603 2336488
Blood creatine phosphokinase increased 102.50 27.42 69 20925 5067 2332024
Sepsis 101.10 27.42 119 20875 18369 2318722
Haemodynamic instability 100.94 27.42 42 20952 1137 2335954
Aphasia 100.26 27.42 67 20927 4861 2332230
Anion gap increased 99.68 27.42 29 20965 254 2336837
Pancreatic steatosis 99.62 27.42 21 20973 34 2337057
Delirium 99.08 27.42 68 20926 5155 2331936
Hypersensitivity 98.96 27.42 133 20861 23460 2313631
Ecchymosis 98.39 27.42 45 20949 1538 2335553
Haemorrhagic stroke 98.29 27.42 40 20954 1022 2336069
Coronary artery disease 97.99 27.42 71 20923 5868 2331223
Treatment noncompliance 97.84 27.42 69 20925 5465 2331626
Musculoskeletal disorder 97.74 27.42 52 20942 2476 2334615
Foetal growth restriction 95.55 27.42 40 20954 1100 2335991
Cardiovascular disorder 95.47 27.42 50 20944 2305 2334786
Muscular weakness 95.24 27.42 104 20890 14793 2322298
Subdural haemorrhage 94.36 27.42 32 20962 481 2336610
Ulcer haemorrhage 94.05 27.42 33 20961 552 2336539
Dermatitis exfoliative 92.28 27.42 40 20954 1201 2335890
Intraventricular haemorrhage 92.10 27.42 30 20964 395 2336696
Conjunctivitis 91.89 27.42 49 20945 2344 2334747
Aortic arteriosclerosis 91.66 27.42 33 20961 597 2336494
Malaise 91.42 27.42 207 20787 55378 2281713
Septic shock 91.38 27.42 73 20921 6981 2330110
Pneumonia aspiration 91.21 27.42 57 20937 3685 2333406
Hypokalaemia 91.07 27.42 87 20907 10567 2326524
Cardiac tamponade 90.70 27.42 35 20959 774 2336317
Wound infection pseudomonas 90.27 27.42 21 20973 65 2337026
Blood pressure increased 89.02 27.42 107 20887 16879 2320212
Blood lactic acid increased 88.98 27.42 35 20959 816 2336275
Mitral valve incompetence 88.96 27.42 49 20945 2501 2334590
Drug reaction with eosinophilia and systemic symptoms 88.84 27.42 65 20929 5453 2331638
Personality disorder 87.80 27.42 28 20966 343 2336748
Tachyarrhythmia 87.24 27.42 32 20962 612 2336479
Arthropathy 86.95 27.42 72 20922 7244 2329847
Coordination abnormal 85.73 27.42 44 20950 1944 2335147
Wheezing 84.69 27.42 67 20927 6317 2330774
Respiratory rate increased 84.51 27.42 40 20954 1480 2335611
Electrocardiogram QRS complex prolonged 83.51 27.42 36 20958 1066 2336025
Microcytic anaemia 83.33 27.42 29 20965 473 2336618
Myocardial ischaemia 83.16 27.42 45 20949 2217 2334874
Thrombosis in device 83.13 27.42 31 20963 622 2336469
White blood cell count increased 82.75 27.42 69 20925 7009 2330082
Oliguria 82.53 27.42 38 20956 1319 2335772
Diverticulum 82.47 27.42 39 20955 1440 2335651
Blood glucose increased 82.40 27.42 88 20906 12202 2324889
Visual impairment 82.07 27.42 86 20908 11669 2325422
Body temperature increased 81.59 27.42 50 20944 3121 2333970
Functional gastrointestinal disorder 81.30 27.42 28 20966 442 2336649
Blood alkaline phosphatase increased 81.11 27.42 66 20928 6479 2330612
Spinal epidural haematoma 80.84 27.42 20 20974 86 2337005
Nasal polyps 79.93 27.42 23 20971 193 2336898
Swollen tongue 79.44 27.42 60 20934 5283 2331808
Left ventricular dysfunction 79.43 27.42 36 20958 1204 2335887
Blister 79.14 27.42 66 20928 6705 2330386
Brain herniation 78.89 27.42 29 20965 558 2336533
Disorientation 78.42 27.42 64 20930 6308 2330783
Haemodialysis 78.41 27.42 42 20952 2027 2335064
Haemolysis 78.33 27.42 34 20960 1024 2336067
Aortic valve stenosis 77.60 27.42 25 20969 317 2336774
Electric shock 77.31 27.42 19 20975 79 2337012
Agranulocytosis 77.29 27.42 50 20944 3432 2333659
Adverse reaction 76.93 27.42 38 20956 1546 2335545
Face oedema 76.30 27.42 52 20942 3896 2333195
Angina unstable 76.10 27.42 36 20958 1330 2335761
Drug abuser 74.82 27.42 32 20962 929 2336162
Generalised tonic-clonic seizure 74.76 27.42 58 20936 5314 2331777
Pharyngeal oedema 74.70 27.42 49 20945 3444 2333647
Cognitive disorder 74.68 27.42 58 20936 5323 2331768
Constipation 74.50 27.42 111 20883 21518 2315573
Anxiety 74.32 27.42 131 20863 29228 2307863
Low birth weight baby 72.55 27.42 30 20964 799 2336292
Iron deficiency anaemia 72.31 27.42 40 20954 2059 2335032
Gastrointestinal sounds abnormal 72.12 27.42 27 20967 548 2336543
Body temperature decreased 71.06 27.42 34 20960 1289 2335802
Sopor 71.05 27.42 50 20944 3945 2333146
Arthralgia 70.87 27.42 185 20809 54100 2282991
Drug dependence 70.74 27.42 45 20949 3000 2334091
Caesarean section 70.09 27.42 50 20944 4031 2333060
Pre-eclampsia 69.85 27.42 35 20959 1469 2335622
Analgesic drug level above therapeutic 69.80 27.42 15 20979 28 2337063
Liver disorder 69.79 27.42 60 20934 6354 2330737
Cholestasis 69.52 27.42 48 20946 3673 2333418
Balance disorder 69.27 27.42 72 20922 9675 2327416
Normochromic normocytic anaemia 69.21 27.42 28 20966 704 2336387
Oligohydramnios 68.31 27.42 30 20964 930 2336161
Blood pressure systolic increased 68.27 27.42 40 20954 2299 2334792
Blood bicarbonate decreased 68.16 27.42 25 20969 478 2336613
Orthostatic hypotension 68.02 27.42 43 20951 2836 2334255
Self-medication 67.46 27.42 26 20968 573 2336518
Hyperventilation 67.28 27.42 32 20962 1197 2335894
Hypoxia 67.24 27.42 58 20936 6169 2330922
Post procedural haematoma 66.96 27.42 22 20972 298 2336793
Renal papillary necrosis 66.40 27.42 15 20979 39 2337052
Seroma 66.16 27.42 21 20973 253 2336838
Abdominal tenderness 65.81 27.42 30 20964 1017 2336074
Electrocardiogram QT prolonged 65.24 27.42 63 20931 7751 2329340
Gastrointestinal ulcer 65.21 27.42 22 20972 325 2336766
Cerebral ischaemia 65.19 27.42 31 20963 1159 2335932
Blood sodium decreased 65.11 27.42 43 20951 3057 2334034
Intestinal ischaemia 64.63 27.42 30 20964 1061 2336030
Cerebellar haemorrhage 64.57 27.42 21 20973 275 2336816
Groin pain 64.42 27.42 32 20962 1318 2335773
Head injury 63.76 27.42 47 20947 3987 2333104
Mouth haemorrhage 63.68 27.42 29 20965 981 2336110
Hepatitis acute 63.38 27.42 33 20961 1502 2335589
Faecaloma 63.19 27.42 28 20966 887 2336204
Small intestinal haemorrhage 62.96 27.42 21 20973 299 2336792
Drug dispensed to wrong patient 62.95 27.42 14 20980 33 2337058
Blood lactate dehydrogenase increased 62.88 27.42 44 20950 3440 2333651
Acute coronary syndrome 62.55 27.42 33 20961 1544 2335547
Gastritis haemorrhagic 62.34 27.42 20 20974 250 2336841
PCO2 decreased 61.21 27.42 20 20974 266 2336825
Tricuspid valve incompetence 61.03 27.42 33 20961 1623 2335468
Purpura 61.00 27.42 34 20960 1776 2335315
Night sweats 60.38 27.42 43 20951 3457 2333634
Oesophageal intramural haematoma 60.10 27.42 11 20983 3 2337088
Back pain 60.07 27.42 125 20869 31534 2305557
Ventricular fibrillation 59.95 27.42 36 20958 2165 2334926
Intervertebral discitis 59.69 27.42 20 20974 289 2336802
Gingival bleeding 59.60 27.42 35 20959 2020 2335071
Lip erosion 59.35 27.42 17 20977 140 2336951
C-reactive protein increased 59.06 27.42 54 20940 6201 2330890
Eating disorder 58.77 27.42 36 20958 2245 2334846
Oesophageal ulcer 58.70 27.42 25 20969 718 2336373
Neurologic neglect syndrome 58.62 27.42 15 20979 76 2337015
Immune thrombocytopenic purpura 58.31 27.42 31 20963 1473 2335618
Hepatitis fulminant 58.25 27.42 24 20970 633 2336458
Therapeutic product effect decreased 58.21 27.42 69 20925 10720 2326371
Alcohol use 58.15 27.42 22 20972 460 2336631
Hepatic cyst 58.04 27.42 24 20970 639 2336452
Inflammatory marker increased 57.89 27.42 23 20971 551 2336540
Pericardial effusion 57.35 27.42 44 20950 3965 2333126
Aplastic anaemia 57.13 27.42 26 20968 878 2336213
Large intestinal ulcer 57.07 27.42 22 20972 485 2336606
Pleural effusion 57.06 27.42 71 20923 11597 2325494
Hepatitis cholestatic 56.91 27.42 28 20966 1129 2335962
Eructation 56.80 27.42 28 20966 1134 2335957
Petechiae 56.72 27.42 34 20960 2038 2335053
Stillbirth 56.71 27.42 30 20964 1411 2335680
Wound dehiscence 56.69 27.42 24 20970 679 2336412
Pancreatitis acute 56.68 27.42 43 20951 3810 2333281
Adjustment disorder 56.42 27.42 17 20977 170 2336921
Photophobia 56.11 27.42 35 20959 2254 2334837
Troponin increased 55.86 27.42 27 20967 1047 2336044
Colitis ischaemic 55.85 27.42 31 20963 1606 2335485
Pulmonary alveolar haemorrhage 55.85 27.42 24 20970 705 2336386
Arteriosclerosis 55.81 27.42 30 20964 1458 2335633
Escherichia infection 55.72 27.42 29 20965 1319 2335772
Otitis media 55.64 27.42 23 20971 612 2336479
Impaired work ability 55.60 27.42 32 20962 1778 2335313
Toxicologic test abnormal 55.52 27.42 16 20978 135 2336956
Accidental death 55.16 27.42 19 20975 300 2336791
Disseminated intravascular coagulation 55.14 27.42 40 20954 3310 2333781
Blood pressure systolic decreased 55.04 27.42 24 20970 731 2336360
Intracranial pressure increased 54.97 27.42 26 20968 960 2336131
Electrolyte imbalance 54.66 27.42 33 20961 2004 2335087
Therapeutic product effect incomplete 54.59 27.42 66 20928 10465 2326626
Pancreatitis 54.41 27.42 58 20936 8021 2329070
Pulseless electrical activity 54.25 27.42 26 20968 989 2336102
Dilatation intrahepatic duct acquired 54.21 27.42 14 20980 74 2337017
Bronchospasm 54.13 27.42 38 20956 2986 2334105
Disease recurrence 54.07 27.42 40 20954 3411 2333680
Renal tubular necrosis 53.94 27.42 30 20964 1560 2335531
Pulmonary hypertension 53.90 27.42 47 20947 5071 2332020
Normal newborn 53.83 27.42 28 20966 1272 2335819
Brain injury 53.60 27.42 25 20969 894 2336197
Embolism 53.56 27.42 28 20966 1285 2335806
Spinal cord compression 53.48 27.42 22 20972 578 2336513
Hyperthermia 53.39 27.42 29 20965 1439 2335652
Drug level above therapeutic 52.97 27.42 21 20973 500 2336591
Cholelithiasis 52.66 27.42 49 20945 5754 2331337
Obstructive airways disorder 52.39 27.42 28 20966 1345 2335746
Gastrooesophageal reflux disease 52.12 27.42 60 20934 9035 2328056
Ventricular tachycardia 51.96 27.42 37 20957 2974 2334117
Chest discomfort 51.82 27.42 76 20918 14519 2322572
Pancytopenia 51.75 27.42 67 20927 11385 2325706
Pain in extremity 51.46 27.42 141 20853 42399 2294692
Synovial fluid analysis 51.37 27.42 11 20983 20 2337071
Anal incontinence 50.92 27.42 30 20964 1742 2335349
Vascular stent stenosis 50.62 27.42 14 20980 100 2336991
Pulmonary congestion 50.59 27.42 31 20963 1934 2335157
Peptic ulcer 50.14 27.42 21 20973 578 2336513
Coma scale abnormal 50.04 27.42 23 20971 795 2336296
Adverse drug reaction 49.76 27.42 56 20938 8227 2328864
Intestinal haemorrhage 49.57 27.42 21 20973 595 2336496
Ventricular arrhythmia 49.54 27.42 21 20973 596 2336495
Aspiration 49.48 27.42 28 20966 1506 2335585
Tubulointerstitial nephritis 49.22 27.42 33 20961 2405 2334686
Palpitations 49.02 27.42 79 20915 16377 2320714
Reye's syndrome 48.86 27.42 11 20983 28 2337063
Serotonin syndrome 48.77 27.42 38 20956 3502 2333589
Ammonia increased 48.50 27.42 22 20972 737 2336354
Loss of personal independence in daily activities 48.49 27.42 45 20949 5266 2331825
Inflammation 47.96 27.42 48 20946 6165 2330926
Blood albumin decreased 47.96 27.42 29 20965 1766 2335325
Insomnia 47.95 27.42 101 20893 25686 2311405
Product prescribing error 47.94 27.42 35 20959 2925 2334166
Chromaturia 47.90 27.42 34 20960 2719 2334372
Premature rupture of membranes 47.79 27.42 23 20971 883 2336208
Post-traumatic stress disorder 47.63 27.42 19 20975 460 2336631
Abnormal loss of weight 47.43 27.42 21 20973 664 2336427
Traumatic intracranial haemorrhage 47.39 27.42 14 20980 130 2336961
Postoperative wound infection 47.35 27.42 25 20969 1171 2335920
Coma hepatic 47.16 27.42 15 20979 182 2336909
Vaginal haemorrhage 47.03 27.42 43 20951 4937 2332154
Tremor 46.93 27.42 88 20906 20573 2316518
Thalamus haemorrhage 46.92 27.42 14 20980 135 2336956
Cushingoid 46.46 27.42 20 20974 590 2336501
Carotid artery thrombosis 46.40 27.42 13 20981 98 2336993
Impaired healing 45.87 27.42 44 20950 5367 2331724
Traumatic haematoma 45.47 27.42 15 20979 206 2336885
Labile blood pressure 45.33 27.42 15 20979 208 2336883
Depression 45.30 27.42 104 20890 28028 2309063
Interleukin level increased 45.10 27.42 11 20983 44 2337047
Crepitations 44.77 27.42 20 20974 646 2336445
Suicidal ideation 44.17 27.42 61 20933 11026 2326065
Intentional product use issue 43.94 27.42 36 20958 3566 2333525
Antinuclear antibody positive 43.93 27.42 23 20971 1059 2336032
Hyperbilirubinaemia 43.92 27.42 26 20968 1523 2335568
Altered state of consciousness 43.81 27.42 37 20957 3823 2333268
Hypotonia 43.79 27.42 27 20967 1703 2335388
Coronary artery stenosis 43.79 27.42 21 20973 800 2336291
Hallucination 43.76 27.42 52 20942 8096 2328995
Affect lability 43.76 27.42 29 20965 2073 2335018
HELLP syndrome 43.71 27.42 15 20979 234 2336857
Procedural haemorrhage 43.50 27.42 18 20976 480 2336611
Arteriovenous malformation 43.49 27.42 14 20980 177 2336914
Electrocardiogram ST segment elevation 43.41 27.42 19 20975 584 2336507
Oxygen saturation decreased 43.39 27.42 50 20944 7536 2329555
Eosinophilia 43.36 27.42 33 20961 2937 2334154
Haemorrhagic transformation stroke 43.02 27.42 15 20979 246 2336845
Basilar artery thrombosis 42.97 27.42 10 20984 31 2337060
Myalgia 42.93 27.42 91 20903 23242 2313849
Tympanic membrane perforation 42.91 27.42 15 20979 248 2336843
PO2 increased 42.88 27.42 13 20981 133 2336958
Antidepressant drug level above therapeutic 42.78 27.42 11 20983 57 2337034
Rash maculo-papular 42.68 27.42 38 20956 4214 2332877
Blood potassium increased 42.61 27.42 29 20965 2167 2334924
Haemorrhage subcutaneous 42.21 27.42 19 20975 625 2336466
Rash erythematous 42.19 27.42 44 20950 5932 2331159
Cholecystitis 42.08 27.42 29 20965 2211 2334880
Oesophageal haemorrhage 41.86 27.42 13 20981 145 2336946
Wound haemorrhage 41.75 27.42 16 20978 347 2336744
Haemothorax 41.74 27.42 17 20977 435 2336656
Creatinine renal clearance decreased 41.61 27.42 21 20973 895 2336196
Pupil fixed 41.52 27.42 17 20977 441 2336650
Diverticulitis 41.37 27.42 37 20957 4128 2332963
Infection 41.21 27.42 77 20917 17952 2319139
Abortion induced 41.20 27.42 34 20960 3402 2333689
Joint swelling 41.18 27.42 74 20920 16745 2320346
Motor dysfunction 40.99 27.42 23 20971 1217 2335874
Aggression 40.72 27.42 39 20955 4747 2332344
Device occlusion 40.59 27.42 20 20974 809 2336282
Acute respiratory failure 40.53 27.42 32 20962 3006 2334085
Erythema multiforme 40.49 27.42 28 20966 2147 2334944
Oedema 40.44 27.42 56 20938 10147 2326944
Left ventricular hypertrophy 40.41 27.42 19 20975 692 2336399
Disturbance in attention 40.39 27.42 42 20952 5643 2331448
Restlessness 40.38 27.42 38 20956 4525 2332566
Hypochromic anaemia 40.36 27.42 14 20980 226 2336865
Joint dislocation 40.14 27.42 24 20970 1432 2335659
Gastrointestinal arteriovenous malformation 40.05 27.42 10 20984 45 2337046
Adenocarcinoma of colon 39.85 27.42 15 20979 309 2336782
Nervous system disorder 39.82 27.42 32 20962 3084 2334007
Peripheral ischaemia 39.56 27.42 19 20975 726 2336365
Tenosynovitis stenosans 39.56 27.42 12 20982 123 2336968
Haemorrhoids 39.11 27.42 28 20966 2269 2334822
Hyperreflexia 39.01 27.42 20 20974 881 2336210
Large intestinal haemorrhage 39.00 27.42 14 20980 251 2336840
Bradypnoea 38.97 27.42 16 20978 418 2336673
Eye haemorrhage 38.96 27.42 23 20971 1340 2335751
Hepatic steatosis 38.96 27.42 32 20962 3181 2333910
Haemorrhagic diathesis 38.76 27.42 17 20977 525 2336566
Atrioventricular block 38.68 27.42 22 20972 1195 2335896
Osteopenia 38.61 27.42 26 20968 1909 2335182
Ejection fraction decreased 38.44 27.42 30 20964 2771 2334320
Dry mouth 38.40 27.42 49 20945 8204 2328887
Dialysis 38.25 27.42 27 20967 2140 2334951
Drug resistance 37.97 27.42 29 20965 2595 2334496
Hypovolaemic shock 37.97 27.42 19 20975 795 2336296
Chills 37.53 27.42 68 20926 15484 2321607
Laryngeal oedema 37.52 27.42 22 20972 1266 2335825
Cerebral haematoma 37.46 27.42 17 20977 570 2336521
Interstitial lung disease 37.33 27.42 47 20947 7765 2329326
Demyelination 37.31 27.42 20 20974 966 2336125
Puncture site haemorrhage 37.15 27.42 11 20983 103 2336988
Muscle abscess 37.06 27.42 11 20983 104 2336987
Spontaneous haematoma 36.76 27.42 12 20982 159 2336932
Periorbital oedema 36.72 27.42 20 20974 998 2336093
Bleeding time prolonged 36.70 27.42 12 20982 160 2336931
Internal haemorrhage 36.65 27.42 17 20977 600 2336491
Abdominal distension 36.64 27.42 54 20940 10357 2326734
Vasculitis 36.61 27.42 27 20967 2291 2334800
Bursitis 36.55 27.42 25 20969 1883 2335208
Duodenitis 36.43 27.42 16 20978 496 2336595
Paraplegia 36.31 27.42 16 20978 500 2336591
Flank pain 36.30 27.42 23 20971 1522 2335569
Feeling jittery 36.27 27.42 25 20969 1907 2335184
Monoclonal B-cell lymphocytosis 36.16 27.42 7 20987 5 2337086
Atelectasis 35.88 27.42 25 20969 1940 2335151
Adrenal insufficiency 35.82 27.42 22 20972 1378 2335713
Acid base balance abnormal 35.78 27.42 9 20985 42 2337049
International normalised ratio decreased 35.58 27.42 18 20976 771 2336320
Emphysema 35.52 27.42 20 20974 1065 2336026
Ischaemia 35.51 27.42 18 20976 774 2336317
Haemorrhage urinary tract 35.40 27.42 12 20982 180 2336911
Blood pressure diastolic decreased 35.35 27.42 20 20974 1075 2336016
Heart rate decreased 35.21 27.42 32 20962 3644 2333447
Swelling 35.10 27.42 68 20926 16282 2320809
Anal stenosis 35.06 27.42 10 20984 81 2337010
Cyanosis 35.06 27.42 30 20964 3155 2333936
Post procedural complication 34.94 27.42 29 20965 2925 2334166
Prothrombin level increased 34.84 27.42 10 20984 83 2337008
Blood glucose decreased 34.52 27.42 30 20964 3222 2333869
Feeling abnormal 34.51 27.42 84 20910 23497 2313594
Eye pain 34.51 27.42 36 20958 4855 2332236
Drug eruption 34.46 27.42 30 20964 3229 2333862
Deep vein thrombosis 34.37 27.42 59 20935 12873 2324218
Temperature intolerance 34.34 27.42 19 20975 978 2336113
Speech disorder 34.30 27.42 41 20953 6423 2330668
Bezoar 34.18 27.42 12 20982 201 2336890
Blood calcium decreased 33.78 27.42 25 20969 2133 2334958
Diarrhoea haemorrhagic 33.67 27.42 21 20973 1352 2335739
Sedation 33.65 27.42 30 20964 3332 2333759
Haemophilus infection 33.62 27.42 11 20983 147 2336944
Cardiomegaly 33.61 27.42 26 20968 2370 2334721
Gastrointestinal ulcer haemorrhage 33.55 27.42 11 20983 148 2336943
Sinusitis 33.39 27.42 67 20927 16459 2320632
Scleritis 33.37 27.42 13 20981 295 2336796
Anal haemorrhage 33.33 27.42 13 20981 296 2336795
Hydrocephalus 33.29 27.42 18 20976 885 2336206
Pulmonary haemorrhage 33.27 27.42 20 20974 1205 2335886
Arrhythmia 33.25 27.42 39 20955 5989 2331102
Dyspnoea exertional 33.21 27.42 38 20956 5682 2331409
Troponin I increased 33.01 27.42 13 20981 304 2336787
Intermittent claudication 32.89 27.42 13 20981 307 2336784
Acute pulmonary oedema 32.70 27.42 20 20974 1243 2335848
Large intestine polyp 32.63 27.42 19 20975 1079 2336012
Neurological symptom 32.61 27.42 18 20976 922 2336169
Paralysis 32.60 27.42 23 20971 1821 2335270
Gastric ulcer perforation 32.40 27.42 12 20982 236 2336855
Presyncope 32.37 27.42 31 20963 3772 2333319
Stridor 32.29 27.42 16 20978 655 2336436
Myelodysplastic syndrome 32.09 27.42 26 20968 2534 2334557
Rales 32.07 27.42 19 20975 1114 2335977
Rash papulosquamous 32.04 27.42 8 20986 36 2337055
Alcohol poisoning 31.98 27.42 13 20981 331 2336760
Placental insufficiency 31.94 27.42 12 20982 246 2336845
Capillary fragility test 31.80 27.42 6 20988 3 2337088
Kounis syndrome 31.76 27.42 12 20982 250 2336841
Embolic stroke 31.65 27.42 16 20978 684 2336407
Perforated ulcer 31.62 27.42 10 20984 119 2336972
Product monitoring error 31.62 27.42 10 20984 119 2336972
Left atrial dilatation 31.58 27.42 12 20982 254 2336837
Migraine 31.52 27.42 51 20943 10602 2326489
Necrosis 31.52 27.42 18 20976 985 2336106
Bundle branch block right 31.49 27.42 17 20977 833 2336258
Myopathy 31.42 27.42 21 20973 1522 2335569
Musculoskeletal stiffness 31.41 27.42 55 20939 12192 2324899
Cerebellar infarction 31.37 27.42 13 20981 348 2336743
Haemorrhoidal haemorrhage 31.33 27.42 15 20979 569 2336522
Hepatorenal failure 31.17 27.42 10 20984 125 2336966
Stent placement 31.04 27.42 16 20978 713 2336378
Facial paresis 30.71 27.42 15 20979 595 2336496
Status epilepticus 30.71 27.42 25 20969 2453 2334638
Diabetic macroangiopathy 30.59 27.42 6 20988 5 2337086
Hypertensive crisis 30.41 27.42 25 20969 2488 2334603
Blood potassium decreased 30.39 27.42 35 20959 5270 2331821
Peptic ulcer haemorrhage 30.33 27.42 9 20985 85 2337006
Thrombocytosis 30.11 27.42 17 20977 910 2336181
Renal haemorrhage 30.05 27.42 11 20983 209 2336882
Blood pressure fluctuation 29.97 27.42 22 20972 1853 2335238
Menorrhagia 29.95 27.42 29 20965 3577 2333514
Pleuritic pain 29.79 27.42 15 20979 636 2336455
Intra-abdominal haematoma 29.61 27.42 12 20982 303 2336788
Red blood cell sedimentation rate increased 29.57 27.42 23 20971 2114 2334977
Mediastinal haematoma 29.54 27.42 7 20987 24 2337067
Tenderness 29.53 27.42 22 20972 1896 2335195
Sensory loss 29.33 27.42 18 20976 1126 2335965
Pulmonary embolism 29.26 27.42 67 20927 18016 2319075
Gastric disorder 29.25 27.42 29 20965 3681 2333410
Amylase increased 29.25 27.42 18 20976 1131 2335960
Electroencephalogram abnormal 29.14 27.42 16 20978 811 2336280
Lung disorder 29.08 27.42 37 20957 6175 2330916
Hepatitis toxic 28.98 27.42 15 20979 674 2336417
Anion gap abnormal 28.94 27.42 8 20986 57 2337034
Skin ulcer 28.85 27.42 30 20964 4029 2333062
Drug ineffective for unapproved indication 28.77 27.42 26 20968 2940 2334151
Diverticulitis intestinal haemorrhagic 28.70 27.42 8 20986 59 2337032
Anticoagulation drug level above therapeutic 28.68 27.42 10 20984 164 2336927
Acute left ventricular failure 28.62 27.42 9 20985 105 2336986
Gastrointestinal oedema 28.51 27.42 11 20983 243 2336848
Ear pain 28.45 27.42 25 20969 2724 2334367
Catheter site haemorrhage 28.40 27.42 13 20981 445 2336646
Chronic obstructive pulmonary disease 28.28 27.42 39 20955 7038 2330053
Erosive duodenitis 28.24 27.42 9 20985 110 2336981
Mouth ulceration 27.96 27.42 29 20965 3883 2333208
Sudden death 27.89 27.42 21 20973 1839 2335252
Urinary incontinence 27.81 27.42 30 20964 4203 2332888
Bradycardia foetal 27.80 27.42 9 20985 116 2336975
Helicobacter infection 27.79 27.42 14 20980 594 2336497
Hyperthyroidism 27.78 27.42 22 20972 2075 2335016
Nephrolithiasis 27.77 27.42 31 20963 4512 2332579
Pharyngeal haemorrhage 27.73 27.42 9 20985 117 2336974
Haemolytic anaemia 27.68 27.42 21 20973 1860 2335231
Lipase increased 27.63 27.42 19 20975 1443 2335648
Rheumatoid nodule 27.58 27.42 14 20980 604 2336487
Jaundice cholestatic 27.47 27.42 14 20980 609 2336482
Ischaemic hepatitis 27.43 27.42 11 20983 270 2336821

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal haemorrhage 4555.99 27.69 1483 17893 12784 1714621
Toxicity to various agents 4030.45 27.69 1631 17745 27510 1699895
Completed suicide 3949.16 27.69 1378 17998 14934 1712471
Melaena 2253.01 27.69 686 18690 4524 1722881
Anaemia 2124.48 27.69 1050 18326 28407 1698998
Gastric haemorrhage 1773.36 27.69 503 18873 2475 1724930
Overdose 1768.06 27.69 778 18598 15923 1711482
Upper gastrointestinal haemorrhage 1384.77 27.69 416 18960 2583 1724822
Haemorrhage 1344.08 27.69 550 18826 9279 1718126
Haemoglobin decreased 1284.63 27.69 629 18747 16485 1710920
Haematemesis 1249.78 27.69 421 18955 3956 1723449
Rectal haemorrhage 1020.12 27.69 385 18991 5157 1722248
Intentional overdose 1019.66 27.69 421 18955 7249 1720156
Cerebral haemorrhage 1019.35 27.69 398 18978 5879 1721526
Hypotension 1016.09 27.69 651 18725 29003 1698402
International normalised ratio increased 994.27 27.69 423 18953 7876 1719529
Gastric ulcer 987.45 27.69 313 19063 2372 1725033
Epistaxis 934.49 27.69 405 18971 7901 1719504
Haematuria 924.26 27.69 391 18985 7169 1720236
Haematochezia 840.39 27.69 324 19052 4608 1722797
Subdural haematoma 802.05 27.69 285 19091 3172 1724233
Intentional product misuse 766.41 27.69 340 19036 7018 1720387
Acute kidney injury 687.96 27.69 548 18828 34396 1693009
Duodenal ulcer 650.15 27.69 206 19170 1554 1725851
Haemorrhage intracranial 645.06 27.69 240 19136 3070 1724335
Haematoma 642.79 27.69 251 19125 3694 1723711
Dyspnoea 637.10 27.69 623 18753 51436 1675969
Faeces discoloured 633.46 27.69 218 19158 2186 1725219
Cardiac arrest 619.86 27.69 380 18996 15550 1711855
Dizziness 598.48 27.69 502 18874 33859 1693546
Acute hepatic failure 584.19 27.69 197 19179 1846 1725559
Drug abuse 554.03 27.69 335 19041 13354 1714051
Cardio-respiratory arrest 550.75 27.69 292 19084 9001 1718404
Gastritis 527.79 27.69 204 19172 2913 1724492
Angioedema 515.00 27.69 283 19093 9381 1718024
Drug interaction 495.63 27.69 413 18963 27545 1699860
Suicide attempt 486.09 27.69 249 19127 7132 1720273
Metabolic acidosis 477.97 27.69 223 19153 5179 1722226
Drug hypersensitivity 473.97 27.69 315 19061 14820 1712585
Coagulopathy 460.10 27.69 179 19197 2602 1724803
Fall 441.19 27.69 382 18994 26832 1700573
Chest pain 437.74 27.69 334 19042 19580 1707825
Haemoptysis 427.34 27.69 200 19176 4676 1722729
Lower gastrointestinal haemorrhage 421.28 27.69 134 19242 1023 1726382
Death 417.32 27.69 651 18725 86792 1640613
Vomiting 416.75 27.69 431 18945 37884 1689521
Blood loss anaemia 404.93 27.69 124 19252 822 1726583
Respiratory arrest 404.79 27.69 204 19172 5635 1721770
Haematocrit decreased 392.23 27.69 181 19195 4092 1723313
Gastric ulcer haemorrhage 381.53 27.69 120 19256 879 1726526
Duodenal ulcer haemorrhage 380.56 27.69 113 19263 664 1726741
Gastritis erosive 377.00 27.69 118 19258 849 1726556
Coma 360.22 27.69 203 19173 7059 1720346
Shock haemorrhagic 359.64 27.69 125 19251 1291 1726114
Asthenia 358.85 27.69 380 18996 34290 1693115
Post procedural haemorrhage 358.44 27.69 125 19251 1305 1726100
Labelled drug-drug interaction medication error 357.60 27.69 123 19253 1228 1726177
Hepatotoxicity 354.65 27.69 153 19223 2931 1724474
Acute myocardial infarction 346.59 27.69 210 19166 8377 1719028
Subarachnoid haemorrhage 343.07 27.69 128 19248 1646 1725759
Abdominal pain 316.59 27.69 286 19090 21204 1706201
Thrombosis in device 312.89 27.69 102 19274 849 1726556
Thrombocytopenia 311.46 27.69 282 19094 20967 1706438
Accidental overdose 307.74 27.69 152 19224 4012 1723393
Iron deficiency anaemia 303.04 27.69 105 19271 1073 1726332
Tachycardia 293.03 27.69 219 19157 12409 1714996
Coronary artery disease 291.24 27.69 198 19178 9648 1717757
Prothrombin time prolonged 284.62 27.69 109 19267 1512 1725893
Aspirin-exacerbated respiratory disease 277.21 27.69 61 19315 67 1727338
Atrial fibrillation 274.91 27.69 227 19149 14884 1712521
Depressed level of consciousness 270.51 27.69 163 19213 6429 1720976
Alanine aminotransferase increased 262.92 27.69 203 19173 12075 1715330
Loss of consciousness 261.33 27.69 219 19157 14656 1712749
Blood creatinine increased 261.00 27.69 213 19163 13733 1713672
Toxic epidermal necrolysis 260.71 27.69 114 19262 2257 1725148
Hepatic failure 257.93 27.69 152 19224 5751 1721654
Syncope 253.85 27.69 211 19165 13958 1713447
Renal failure 253.48 27.69 245 19131 19772 1707633
Aspartate aminotransferase increased 252.74 27.69 188 19188 10568 1716837
Medication error 236.18 27.69 133 19243 4610 1722795
Angina pectoris 234.53 27.69 135 19241 4883 1722522
Oesophagitis 230.93 27.69 95 19281 1606 1725799
Stevens-Johnson syndrome 222.90 27.69 114 19262 3243 1724162
Retroperitoneal haematoma 222.89 27.69 66 19310 383 1727022
Intraventricular haemorrhage 222.80 27.69 70 19306 510 1726895
Contraindicated product administered 221.33 27.69 88 19288 1356 1726049
Cerebrovascular accident 221.11 27.69 216 19160 17650 1709755
Poisoning 219.03 27.69 103 19273 2429 1724976
Multiple organ dysfunction syndrome 215.87 27.69 161 19215 9081 1718324
Hepatic necrosis 213.83 27.69 72 19304 669 1726736
Nausea 207.27 27.69 355 19021 50841 1676564
Occult blood positive 203.25 27.69 65 19311 505 1726900
Duodenitis 202.95 27.69 67 19309 582 1726823
Pallor 201.19 27.69 107 19269 3304 1724101
Blood urea increased 199.72 27.69 119 19257 4592 1722813
Liver injury 198.84 27.69 88 19288 1794 1725611
Muscle haemorrhage 197.68 27.69 70 19306 766 1726639
Contusion 194.12 27.69 122 19254 5187 1722218
Blood pressure decreased 193.90 27.69 140 19236 7506 1719899
Abdominal pain upper 193.16 27.69 162 19214 10839 1716566
Bradycardia 190.92 27.69 158 19218 10376 1717029
Diverticulum 188.67 27.69 71 19305 935 1726470
Headache 188.32 27.69 274 19102 34102 1693303
Confusional state 187.99 27.69 215 19161 21063 1706342
Myocardial infarction 185.56 27.69 241 19135 26933 1700472
Subdural haemorrhage 184.99 27.69 62 19314 567 1726838
Hypertension 182.86 27.69 203 19173 19245 1708160
Condition aggravated 182.29 27.69 211 19165 20939 1706466
Cardiac failure 181.91 27.69 166 19210 12436 1714969
Fatigue 180.83 27.69 333 19043 50448 1676957
Peptic ulcer 176.98 27.69 57 19319 454 1726951
Hemiparesis 176.16 27.69 91 19285 2643 1724762
Hiatus hernia 173.04 27.69 67 19309 958 1726447
Foetal exposure during pregnancy 171.73 27.69 121 19255 6238 1721167
Brain oedema 170.65 27.69 83 19293 2113 1725292
Transient ischaemic attack 169.90 27.69 108 19268 4683 1722722
Substance abuse 167.32 27.69 65 19311 938 1726467
Erosive duodenitis 166.09 27.69 46 19330 201 1727204
Gastrointestinal ulcer 165.95 27.69 49 19327 281 1727124
Mallory-Weiss syndrome 165.36 27.69 49 19327 285 1727120
Pyrexia 164.77 27.69 304 19072 46096 1681309
Cerebral infarction 164.06 27.69 109 19267 5100 1722305
Renal impairment 163.80 27.69 155 19221 12159 1715246
Shock 163.19 27.69 100 19276 4061 1723344
Seizure 162.98 27.69 196 19180 20245 1707160
Haemorrhagic stroke 162.95 27.69 68 19308 1193 1726212
Vascular stent thrombosis 162.01 27.69 53 19323 446 1726959
Oesophageal ulcer 160.54 27.69 56 19320 584 1726821
Drug ineffective 160.22 27.69 362 19014 63439 1663966
Dyspnoea exertional 158.10 27.69 98 19278 4063 1723342
Rhabdomyolysis 157.91 27.69 145 19231 10945 1716460
General physical health deterioration 155.49 27.69 155 19221 12963 1714442
Hyperkalaemia 154.42 27.69 128 19248 8419 1718986
Hepatic function abnormal 151.36 27.69 117 19259 6957 1720448
Ventricular tachycardia 148.23 27.69 91 19285 3707 1723698
Vascular pseudoaneurysm 147.60 27.69 46 19330 325 1727080
Aphasia 145.56 27.69 87 19289 3374 1724031
Premature baby 145.06 27.69 82 19294 2860 1724545
Urticaria 143.89 27.69 144 19232 12097 1715308
Agitation 141.32 27.69 136 19240 10890 1716515
Somnolence 140.81 27.69 165 19211 16574 1710831
Respiratory failure 139.01 27.69 153 19223 14352 1713053
Unresponsive to stimuli 138.89 27.69 94 19282 4535 1722870
Thrombosis 138.70 27.69 114 19262 7407 1719998
Jaundice 137.90 27.69 104 19272 5958 1721447
Post procedural haematoma 137.90 27.69 42 19334 272 1727133
Diverticulum intestinal haemorrhagic 136.35 27.69 42 19334 284 1727121
Small intestinal haemorrhage 135.46 27.69 43 19333 325 1727080
Respiratory depression 133.93 27.69 71 19305 2176 1725229
Haemothorax 133.70 27.69 50 19326 646 1726759
Therapy non-responder 130.49 27.69 102 19274 6164 1721241
Ischaemic stroke 127.77 27.69 78 19298 3144 1724261
Pulmonary congestion 127.68 27.69 64 19312 1741 1725664
Product administration error 126.18 27.69 75 19301 2878 1724527
Mental status changes 124.58 27.69 98 19278 5977 1721428
Procedural haemorrhage 124.25 27.69 42 19334 395 1727010
Mouth haemorrhage 123.71 27.69 51 19325 866 1726539
Ventricular fibrillation 123.01 27.69 72 19304 2684 1724721
Product use in unapproved indication 122.21 27.69 117 19259 9305 1718100
Pulmonary alveolar haemorrhage 121.52 27.69 54 19322 1111 1726294
Haemorrhoids 121.30 27.69 62 19314 1759 1725646
Extradural haematoma 121.17 27.69 37 19339 242 1727163
Anion gap 121.12 27.69 29 19347 59 1727346
Gingival bleeding 119.12 27.69 55 19321 1241 1726164
Hemiplegia 117.25 27.69 55 19321 1288 1726117
Pneumonia 115.63 27.69 262 19114 45920 1681485
Hydrocephalus 114.90 27.69 48 19328 844 1726561
Acidosis 114.55 27.69 56 19320 1441 1725964
Heart rate increased 114.46 27.69 96 19280 6414 1720991
Gastrointestinal arteriovenous malformation 113.40 27.69 27 19349 53 1727352
Diarrhoea 112.76 27.69 285 19091 53567 1673838
Pneumonia aspiration 112.41 27.69 87 19289 5179 1722226
Coronary artery stenosis 111.62 27.69 56 19320 1526 1725879
Venous pressure jugular increased 111.58 27.69 28 19348 75 1727330
Anaphylactic reaction 111.32 27.69 92 19284 6021 1721384
Large intestine polyp 111.12 27.69 48 19328 920 1726485
Hyperhidrosis 109.83 27.69 126 19250 12362 1715043
Pulmonary oedema 109.39 27.69 94 19282 6492 1720913
Blood pH decreased 108.49 27.69 39 19337 447 1726958
Alcohol use 106.96 27.69 45 19331 806 1726599
Muscular weakness 106.72 27.69 113 19263 10136 1717269
Exposure via ingestion 106.13 27.69 42 19334 638 1726767
Blood bicarbonate decreased 105.96 27.69 37 19339 387 1727018
Cerebral haematoma 105.84 27.69 43 19333 702 1726703
Platelet count decreased 105.59 27.69 142 19234 16381 1711024
Ulcer 105.46 27.69 49 19327 1122 1726283
Hypovolaemic shock 104.15 27.69 45 19331 863 1726542
Retroperitoneal haemorrhage 103.32 27.69 38 19338 467 1726938
Vascular stent stenosis 103.23 27.69 31 19345 190 1727215
Activated partial thromboplastin time prolonged 102.51 27.69 50 19326 1280 1726125
Ecchymosis 101.23 27.69 46 19330 999 1726406
Tachypnoea 101.03 27.69 60 19316 2298 1725107
Oedema peripheral 99.91 27.69 134 19242 15416 1711989
Head injury 99.36 27.69 65 19311 2959 1724446
Pulmonary haemorrhage 99.31 27.69 53 19323 1646 1725759
Gastrooesophageal reflux disease 97.50 27.69 76 19300 4571 1722834
Incorrect dose administered 94.16 27.69 91 19285 7318 1720087
Cardiogenic shock 93.70 27.69 58 19318 2396 1725009
Ulcer haemorrhage 93.70 27.69 34 19342 401 1727004
Haemodynamic instability 93.36 27.69 47 19329 1290 1726115
Hypoglycaemia 93.15 27.69 96 19280 8342 1719063
Abdominal wall haematoma 93.01 27.69 31 19345 278 1727127
Off label use 92.23 27.69 215 19161 38356 1689049
Lactic acidosis 90.90 27.69 76 19300 5053 1722352
Liver disorder 90.67 27.69 79 19297 5557 1721848
Cardiac tamponade 90.57 27.69 42 19334 957 1726448
Pericardial haemorrhage 89.58 27.69 35 19341 513 1726892
Circulatory collapse 89.01 27.69 64 19312 3403 1724002
Angina unstable 87.50 27.69 53 19323 2105 1725300
Respiratory tract haemorrhage 86.99 27.69 24 19352 103 1727302
Transaminases increased 86.41 27.69 66 19310 3851 1723554
Chest discomfort 85.64 27.69 86 19290 7245 1720160
Acute respiratory distress syndrome 85.37 27.69 63 19313 3488 1723917
Dysarthria 85.18 27.69 74 19302 5185 1722220
Haemorrhoidal haemorrhage 85.11 27.69 34 19342 530 1726875
Disseminated intravascular coagulation 84.38 27.69 63 19313 3551 1723854
Colitis microscopic 84.07 27.69 30 19346 336 1727069
Actinic keratosis 84.02 27.69 34 19342 549 1726856
Acute coronary syndrome 83.23 27.69 53 19323 2302 1725103
Hepatitis 82.84 27.69 71 19305 4884 1722521
Cardiac ventricular thrombosis 82.57 27.69 24 19352 129 1727276
Myocardial ischaemia 82.10 27.69 59 19317 3134 1724271
Coronary artery occlusion 81.93 27.69 50 19326 2013 1725392
Traumatic intracranial haemorrhage 81.41 27.69 25 19351 167 1727238
Eye haemorrhage 80.85 27.69 37 19339 817 1726588
Gastritis haemorrhagic 80.53 27.69 27 19349 247 1727158
Haemorrhagic transformation stroke 80.16 27.69 28 19348 293 1727112
Nasal disorder 80.16 27.69 25 19351 177 1727228
Lethargy 79.77 27.69 82 19294 7102 1720303
Haemorrhage urinary tract 79.47 27.69 29 19347 348 1727057
Sleep disorder due to general medical condition, insomnia type 79.38 27.69 23 19353 122 1727283
Compartment syndrome 79.06 27.69 32 19344 517 1726888
Kounis syndrome 78.88 27.69 30 19346 407 1726998
Haemodialysis 78.15 27.69 53 19323 2563 1724842
Arteriosclerosis coronary artery 78.08 27.69 47 19329 1845 1725560
Hepatic encephalopathy 77.09 27.69 50 19326 2242 1725163
Encephalopathy 76.89 27.69 65 19311 4387 1723018
Drug-induced liver injury 76.85 27.69 57 19319 3180 1724225
Bowen's disease 76.59 27.69 27 19349 291 1727114
International normalised ratio decreased 76.38 27.69 36 19340 852 1726553
Hepatic enzyme increased 76.10 27.69 77 19299 6544 1720861
Erosive oesophagitis 74.96 27.69 26 19350 266 1727139
Leukocytosis 74.58 27.69 58 19318 3475 1723930
Tongue haematoma 74.10 27.69 18 19358 40 1727365
Troponin increased 73.99 27.69 40 19336 1275 1726130
Cardiac murmur 73.90 27.69 39 19337 1183 1726222
Intestinal haemorrhage 73.13 27.69 31 19345 566 1726839
Dyspepsia 72.49 27.69 66 19310 4919 1722486
Pericardial effusion 72.32 27.69 56 19320 3334 1724071
Petechiae 72.28 27.69 42 19334 1543 1725862
Liver function test abnormal 72.12 27.69 70 19306 5656 1721749
Brain death 71.79 27.69 29 19347 466 1726939
Oesophageal haemorrhage 71.34 27.69 24 19352 222 1727183
Reye's syndrome 71.14 27.69 16 19360 21 1727384
Large intestinal haemorrhage 71.03 27.69 25 19351 268 1727137
Urinary bladder haemorrhage 71.02 27.69 26 19350 315 1727090
Cholestasis 70.57 27.69 57 19319 3608 1723797
Blood alkaline phosphatase increased 70.16 27.69 66 19310 5129 1722276
Treatment noncompliance 70.09 27.69 66 19310 5135 1722270
Precancerous skin lesion 69.89 27.69 21 19355 129 1727276
Septic shock 69.88 27.69 81 19295 8028 1719377
Bezoar 69.75 27.69 21 19355 130 1727275
Speech disorder 69.65 27.69 62 19314 4486 1722919
Coronary artery restenosis 69.24 27.69 24 19352 245 1727160
Pancreatitis acute 69.21 27.69 59 19317 4028 1723377
Helicobacter infection 69.08 27.69 27 19349 396 1727009
Electrocardiogram QRS complex prolonged 68.45 27.69 32 19344 743 1726662
Haemobilia 68.23 27.69 19 19357 85 1727320
Cough 68.16 27.69 126 19250 19071 1708334
Analgesic drug level increased 68.05 27.69 19 19357 86 1727319
Rash 67.89 27.69 192 19184 38501 1688904
Brain herniation 67.41 27.69 30 19346 619 1726786
Blood urine present 66.76 27.69 43 19333 1905 1725500
Respiratory distress 66.75 27.69 64 19312 5093 1722312
Decreased appetite 65.88 27.69 141 19235 23730 1703675
Left ventricular dysfunction 65.82 27.69 36 19340 1175 1726230
Sepsis 65.79 27.69 125 19251 19313 1708092
Asthma 65.64 27.69 62 19314 4842 1722563
Haemorrhagic arteriovenous malformation 65.60 27.69 17 19359 54 1727351
Urine output decreased 64.76 27.69 38 19338 1422 1725983
Low birth weight baby 64.34 27.69 32 19344 855 1726550
Drug eruption 63.87 27.69 49 19327 2877 1724528
Chromaturia 63.66 27.69 47 19329 2603 1724802
Prescribed underdose 63.62 27.69 38 19338 1470 1725935
Ejection fraction decreased 63.55 27.69 44 19332 2201 1725204
Naevus flammeus 62.81 27.69 15 19361 30 1727375
Gastrointestinal ulcer haemorrhage 62.65 27.69 19 19357 121 1727284
Nervous system disorder 62.30 27.69 45 19331 2409 1724996
Basilar artery thrombosis 62.16 27.69 15 19361 32 1727373
Arrhythmia 62.01 27.69 66 19310 5950 1721455
Anion gap increased 61.60 27.69 22 19354 247 1727158
Diverticulum intestinal 61.47 27.69 26 19350 472 1726933
Hypoxic-ischaemic encephalopathy 61.23 27.69 31 19345 861 1726544
Blood potassium increased 61.07 27.69 45 19331 2485 1724920
Embolic stroke 60.96 27.69 30 19346 783 1726622
Pulseless electrical activity 60.12 27.69 32 19344 988 1726417
Pleural effusion 59.81 27.69 88 19288 11022 1716383
Abdominal tenderness 59.80 27.69 27 19349 577 1726828
Oedema 59.19 27.69 69 19307 6879 1720526
Oesophageal obstruction 59.01 27.69 17 19359 88 1727317
Duodenal ulcer perforation 58.55 27.69 22 19354 288 1727117
Milk-alkali syndrome 58.30 27.69 16 19360 67 1727338
Arterial haemorrhage 58.26 27.69 19 19357 158 1727247
Blood creatine phosphokinase increased 57.88 27.69 77 19299 8779 1718626
Pulmonary haematoma 57.83 27.69 13 19363 17 1727388
Thalamus haemorrhage 57.37 27.69 20 19356 208 1727197
Vitreous haemorrhage 57.07 27.69 25 19351 496 1726909
White blood cell count decreased 56.65 27.69 94 19282 13055 1714350
Ammonia increased 56.65 27.69 29 19347 825 1726580
Arteriosclerosis 56.55 27.69 38 19338 1809 1725596
Renal tubular necrosis 56.41 27.69 40 19336 2079 1725326
Oxygen saturation decreased 56.27 27.69 61 19315 5614 1721791
Product prescribing error 56.23 27.69 42 19334 2368 1725037
Nasal polyps 55.61 27.69 19 19357 185 1727220
Hypoxia 55.50 27.69 62 19314 5901 1721504
Blood bilirubin increased 55.13 27.69 63 19313 6147 1721258
Immune thrombocytopenic purpura 55.12 27.69 34 19342 1395 1726010
Coronary artery thrombosis 55.00 27.69 25 19351 543 1726862
Orthostatic hypotension 54.98 27.69 48 19328 3383 1724022
Tubulointerstitial nephritis 54.83 27.69 45 19331 2913 1724492
Post procedural complication 54.46 27.69 41 19335 2339 1725066
Microcytic anaemia 54.32 27.69 22 19354 356 1727049
Atrioventricular block first degree 54.14 27.69 29 19347 907 1726498
Dizziness postural 53.89 27.69 28 19348 822 1726583
Self-medication 53.64 27.69 26 19350 656 1726749
Lymphocyte stimulation test positive 53.49 27.69 20 19356 258 1727147
Drug level increased 53.06 27.69 43 19333 2734 1724671
Wheezing 52.72 27.69 51 19325 4102 1723303
Intestinal diaphragm disease 52.55 27.69 14 19362 51 1727354
Delirium 52.23 27.69 62 19314 6300 1721105
Transfusion 51.95 27.69 30 19346 1089 1726316
Spinal epidural haematoma 51.72 27.69 14 19362 55 1727350
Haemolytic anaemia 51.55 27.69 36 19340 1826 1725579
Benign gastrointestinal neoplasm 51.55 27.69 11 19365 9 1727396
Blood glucose increased 51.52 27.69 80 19296 10504 1716901
Carcinoma in situ of skin 51.49 27.69 13 19363 36 1727369
Respiratory alkalosis 51.47 27.69 19 19357 236 1727169
Hepatocellular injury 51.37 27.69 45 19331 3186 1724219
Chronic kidney disease 51.06 27.69 51 19325 4266 1723139
Hyphaema 50.94 27.69 15 19361 85 1727320
Conjunctival haemorrhage 50.71 27.69 23 19353 497 1726908
Helicobacter test positive 50.50 27.69 16 19360 120 1727285
Respiratory rate increased 50.45 27.69 31 19345 1263 1726142
International normalised ratio abnormal 50.36 27.69 27 19349 846 1726559
Dysphagia 49.69 27.69 77 19299 10091 1717314
Blood lactic acid increased 49.62 27.69 27 19349 872 1726533
Subcutaneous haematoma 49.55 27.69 18 19358 213 1727192
Drug resistance 49.39 27.69 44 19332 3186 1724219
Acute respiratory failure 48.87 27.69 42 19334 2898 1724507
Urinary tract infection 48.39 27.69 76 19300 10077 1717328
Drug screen positive 48.17 27.69 28 19348 1029 1726376
Back pain 47.97 27.69 100 19276 16513 1710892
Blood pressure increased 47.83 27.69 78 19298 10675 1716730
Cerebellar haemorrhage 47.80 27.69 19 19357 292 1727113
C-reactive protein increased 47.73 27.69 57 19319 5828 1721577
Disorientation 47.73 27.69 55 19321 5414 1721991
Neurological symptom 47.03 27.69 24 19352 678 1726727
White blood cell count increased 46.89 27.69 63 19313 7249 1720156
Paraesthesia 46.74 27.69 76 19300 10375 1717030
Urinary retention 46.65 27.69 54 19322 5341 1722064
Haemorrhagic diathesis 46.43 27.69 22 19354 527 1726878
Arteriovenous malformation 46.27 27.69 16 19360 162 1727243
Hepatitis acute 46.19 27.69 29 19347 1228 1726177
Dissociation 46.05 27.69 18 19358 264 1727141
Gait disturbance 46.00 27.69 84 19292 12586 1714819
Oesophageal perforation 45.86 27.69 15 19361 126 1727279
Gamma-glutamyltransferase increased 45.72 27.69 52 19324 5046 1722359
Gastrointestinal injury 45.65 27.69 14 19362 93 1727312
Deep vein thrombosis 45.54 27.69 73 19303 9847 1717558
Cardiovascular disorder 45.52 27.69 38 19338 2519 1724886
Intracranial pressure increased 45.44 27.69 24 19352 729 1726676
Alveolitis 45.42 27.69 19 19357 335 1727070
Skin laceration 45.36 27.69 34 19342 1927 1725478
Dieulafoy's vascular malformation 45.20 27.69 12 19364 43 1727362
Electrocardiogram ST segment depression 44.98 27.69 21 19355 486 1726919
Normochromic normocytic anaemia 44.96 27.69 23 19353 653 1726752
Dehydration 44.94 27.69 101 19275 17557 1709848
Pancytopenia 44.70 27.69 78 19298 11279 1716126
Coma scale abnormal 44.60 27.69 22 19354 577 1726828
Gastric ulcer perforation 44.45 27.69 16 19360 184 1727221
Heart rate decreased 44.41 27.69 39 19337 2770 1724635
Liver transplant 44.36 27.69 22 19354 584 1726821
Paralysis 44.25 27.69 29 19347 1323 1726082
Constipation 44.14 27.69 91 19285 14909 1712496
Intentional self-injury 44.05 27.69 38 19338 2635 1724770
Facial asymmetry 43.77 27.69 12 19364 50 1727355
Ventricular hypokinesia 43.69 27.69 23 19353 694 1726711
Product use issue 43.42 27.69 66 19310 8505 1718900
Intra-abdominal haemorrhage 43.42 27.69 19 19357 376 1727029
Dermatomyositis 43.39 27.69 17 19359 251 1727154
Colonic haematoma 43.30 27.69 10 19366 16 1727389
Electrocardiogram ST segment elevation 43.20 27.69 25 19351 911 1726494
Oesophagitis haemorrhagic 43.17 27.69 11 19365 32 1727373
Bleeding time prolonged 43.02 27.69 15 19361 156 1727249
Diabetes mellitus inadequate control 42.74 27.69 32 19344 1810 1725595
Obstructive airways disorder 42.56 27.69 26 19350 1048 1726357
Brain stem haemorrhage 42.27 27.69 16 19360 214 1727191
Patent ductus arteriosus 41.99 27.69 22 19354 657 1726748
Stent placement 41.95 27.69 25 19351 963 1726442
Hyperglycaemia 41.84 27.69 50 19326 5115 1722290
Polypectomy 41.81 27.69 13 19363 91 1727314
Methaemoglobinaemia 41.61 27.69 18 19358 346 1727059
Fat embolism 41.44 27.69 13 19363 94 1727311
Ventricular extrasystoles 41.33 27.69 32 19344 1904 1725501
Brain midline shift 41.32 27.69 15 19361 177 1727228
Non-cardiac chest pain 41.31 27.69 20 19356 503 1726902
Peptic ulcer haemorrhage 41.09 27.69 13 19363 97 1727308
Red blood cell count decreased 40.77 27.69 42 19334 3644 1723761
Pupil fixed 40.59 27.69 18 19358 368 1727037
Dermatitis exfoliative 40.48 27.69 29 19347 1532 1725873
Infarction 40.47 27.69 22 19354 709 1726696
Pharyngeal haematoma 40.37 27.69 9 19367 11 1727394
Vasculitis 40.24 27.69 29 19347 1546 1725859
Gastrointestinal vascular malformation haemorrhagic 40.09 27.69 11 19365 46 1727359
Barrett's oesophagus 39.92 27.69 17 19359 314 1727091
Anuria 39.85 27.69 31 19345 1857 1725548
Environmental exposure 39.72 27.69 11 19365 48 1727357
Spinal cord haemorrhage 39.62 27.69 12 19364 76 1727329
Tumour haemorrhage 39.38 27.69 20 19356 559 1726846
Diverticulitis intestinal haemorrhagic 39.22 27.69 12 19364 79 1727326
Internal haemorrhage 39.00 27.69 20 19356 571 1726834
Laryngeal oedema 38.90 27.69 23 19353 873 1726532
Hepatomegaly 38.49 27.69 29 19347 1656 1725749
Malaise 38.18 27.69 132 19244 29433 1697972
Pulmonary embolism 38.15 27.69 79 19297 12980 1714425
Cardiomegaly 38.09 27.69 33 19343 2301 1725104
Skin necrosis 38.01 27.69 22 19354 802 1726603
Hypokalaemia 37.97 27.69 53 19323 6321 1721084
Presyncope 37.81 27.69 35 19341 2663 1724742
Hepatitis cholestatic 37.64 27.69 26 19350 1295 1726110
Glomerular filtration rate decreased 37.62 27.69 27 19349 1430 1725975
Drug abuser 37.62 27.69 27 19349 1430 1725975
Poisoning deliberate 37.57 27.69 22 19354 820 1726585
Hypothermia 37.54 27.69 29 19347 1719 1725686
Lichen planus 37.53 27.69 15 19361 234 1727171
Inguinal hernia 37.46 27.69 24 19352 1053 1726352
Platelet dysfunction 37.42 27.69 10 19366 37 1727368
Facial paralysis 37.31 27.69 30 19346 1886 1725519
Dialysis 37.25 27.69 33 19343 2371 1725034
Cerebral ischaemia 37.03 27.69 24 19352 1074 1726331
Mitral valve incompetence 36.95 27.69 30 19346 1912 1725493
Lichenoid keratosis 36.75 27.69 17 19359 385 1727020
Brain natriuretic peptide increased 36.74 27.69 19 19357 552 1726853
Perirenal haematoma 36.68 27.69 11 19365 67 1727338
Small intestine ulcer 36.67 27.69 12 19364 101 1727304
Cholecystitis acute 36.67 27.69 22 19354 858 1726547
Peripheral artery stenosis 36.39 27.69 13 19363 146 1727259
Drug reaction with eosinophilia and systemic symptoms 36.10 27.69 46 19330 5024 1722381
Blood pressure systolic increased 36.00 27.69 28 19348 1677 1725728
Haemolysis 35.93 27.69 24 19352 1131 1726274
Brain injury 35.92 27.69 23 19353 1008 1726397
Haemorrhage subcutaneous 35.91 27.69 18 19358 489 1726916
Eye disorder 35.83 27.69 27 19349 1542 1725863
Gastric disorder 35.71 27.69 29 19347 1849 1725556
Pruritus 35.66 27.69 110 19266 23112 1704293
Large intestinal ulcer 35.60 27.69 16 19360 338 1727067
Diastolic dysfunction 35.58 27.69 18 19358 499 1726906
Apnoea 35.48 27.69 26 19350 1423 1725982
Splenic rupture 35.26 27.69 16 19360 346 1727059
Hypersensitivity 35.10 27.69 67 19309 10377 1717028
Craniocerebral injury 34.99 27.69 17 19359 431 1726974
Shone complex 34.95 27.69 8 19368 12 1727393
Anion gap abnormal 34.87 27.69 9 19367 28 1727377
Systemic inflammatory response syndrome 34.86 27.69 21 19355 825 1726580
Swollen tongue 34.73 27.69 34 19342 2774 1724631
Spontaneous haematoma 34.49 27.69 12 19364 124 1727281
PO2 increased 34.49 27.69 12 19364 124 1727281
Peripheral ischaemia 34.36 27.69 21 19355 847 1726558
Haemarthrosis 34.27 27.69 19 19357 637 1726768
Inflammation 34.05 27.69 37 19339 3413 1723992
Polymerase chain reaction 33.84 27.69 8 19368 15 1727390
Hyperkinetic heart syndrome 33.82 27.69 7 19369 4 1727401
Supravalvular aortic stenosis 33.82 27.69 7 19369 4 1727401
Haemorrhagic ascites 33.76 27.69 10 19366 58 1727347
Renal haemorrhage 33.72 27.69 14 19362 242 1727163
Pain in extremity 33.64 27.69 93 19283 18379 1709026
Therapeutic product cross-reactivity 33.41 27.69 14 19362 248 1727157
Rectal ulcer 33.36 27.69 13 19363 189 1727216
Blood ethanol increased 33.34 27.69 10 19366 61 1727344
Cardiac failure congestive 33.04 27.69 82 19294 15188 1712217
Incorrect product administration duration 33.00 27.69 22 19354 1033 1726372
Agranulocytosis 32.96 27.69 37 19339 3539 1723866
Skin haemorrhage 32.90 27.69 20 19356 799 1726606
Cardiotoxicity 32.70 27.69 20 19356 808 1726597
Lip oedema 32.69 27.69 18 19358 595 1726810
Gastric polyps 32.69 27.69 13 19363 200 1727205
Thrombotic thrombocytopenic purpura 32.69 27.69 19 19357 698 1726707
Tongue oedema 32.67 27.69 18 19358 596 1726809
Mucosal haemorrhage 32.63 27.69 13 19363 201 1727204
Erythema 32.62 27.69 78 19298 14110 1713295
Retinal haemorrhage 32.59 27.69 23 19353 1186 1726219
Gastrointestinal necrosis 32.42 27.69 18 19358 605 1726800
Weight decreased 32.39 27.69 105 19271 22648 1704757
Cyanosis 32.37 27.69 32 19344 2642 1724763
Periorbital oedema 32.28 27.69 19 19357 715 1726690
Rheumatoid nodule 32.22 27.69 12 19364 153 1727252
Dysuria 32.15 27.69 37 19339 3635 1723770
Ventricular dysfunction 32.15 27.69 18 19358 615 1726790
Sudden cardiac death 32.08 27.69 20 19356 836 1726569
Hypovolaemia 32.07 27.69 23 19353 1217 1726188
Gastrointestinal polyp haemorrhage 31.92 27.69 10 19366 72 1727333
Creatinine renal clearance decreased 31.80 27.69 19 19357 735 1726670
Rheumatoid arthritis 31.70 27.69 41 19335 4544 1722861
Renal tubular disorder 31.68 27.69 20 19356 855 1726550
Eosinophilia 31.66 27.69 36 19340 3491 1723914
Conjunctival oedema 31.53 27.69 12 19364 163 1727242
Metabolic alkalosis 31.51 27.69 13 19363 221 1727184
Genitalia external ambiguous 31.46 27.69 8 19368 23 1727382
Disease recurrence 31.44 27.69 31 19345 2551 1724854
Abdominal discomfort 31.43 27.69 59 19317 9022 1718383
Hepatic steatosis 31.42 27.69 31 19345 2553 1724852
Colitis ischaemic 31.41 27.69 20 19356 868 1726537
Nephropathy toxic 31.37 27.69 26 19350 1706 1725699
Atrial tachycardia 31.36 27.69 14 19362 291 1727114
Acquired Von Willebrand's disease 31.21 27.69 7 19369 9 1727396
Drug intolerance 31.15 27.69 47 19329 6015 1721390
Haemorrhagic cerebral infarction 31.14 27.69 12 19364 169 1727236
Palpitations 31.07 27.69 50 19326 6764 1720641
Urinary tract discomfort 30.78 27.69 7 19369 10 1727395
Blood chloride decreased 30.71 27.69 17 19359 568 1726837
Drug withdrawal syndrome 30.57 27.69 40 19336 4485 1722920
Body temperature increased 30.50 27.69 31 19345 2646 1724759
Accidental exposure to product 30.46 27.69 38 19338 4063 1723342
Pharyngeal haemorrhage 30.44 27.69 11 19365 128 1727277
Abdominal pain lower 30.33 27.69 22 19354 1185 1726220
Congenital bladder anomaly 30.28 27.69 8 19368 28 1727377
Pain 30.15 27.69 114 19262 26543 1700862
Multiple injuries 29.90 27.69 14 19362 326 1727079
Puncture site haemorrhage 29.77 27.69 10 19366 92 1727313
Prothrombin time abnormal 29.77 27.69 11 19365 137 1727268
Cholestatic liver injury 29.72 27.69 13 19363 257 1727148
Benign prostatic hyperplasia 29.60 27.69 23 19353 1375 1726030
Oesophagitis ulcerative 29.55 27.69 11 19365 140 1727265
Concomitant disease progression 29.42 27.69 16 19360 516 1726889
Amaurosis 29.41 27.69 11 19365 142 1727263
Wound haemorrhage 29.40 27.69 14 19362 339 1727066
Tinnitus 29.34 27.69 33 19343 3162 1724243
Hyponatraemia 29.34 27.69 57 19319 8943 1718462
Subarachnoid haematoma 28.99 27.69 7 19369 15 1727390
Actinic elastosis 28.99 27.69 7 19369 15 1727390
Basal cell carcinoma 28.74 27.69 29 19347 2454 1724951
Acute right ventricular failure 28.68 27.69 7 19369 16 1727389
Neonatal respiratory depression 28.58 27.69 9 19367 66 1727339
Diverticulitis 28.47 27.69 28 19348 2297 1725108
Oesophageal ulcer haemorrhage 28.35 27.69 9 19367 68 1727337
Ischaemic cerebral infarction 28.31 27.69 12 19364 219 1727186
Sinus tachycardia 28.27 27.69 29 19347 2503 1724902
Supraventricular tachycardia 28.13 27.69 24 19352 1639 1725766
Cardiac failure acute 28.04 27.69 21 19355 1188 1726217
Intracardiac thrombus 27.97 27.69 16 19360 570 1726835
Polyp 27.94 27.69 15 19361 471 1726934
Injury 27.92 27.69 31 19345 2929 1724476
Left ventricular failure 27.88 27.69 17 19359 683 1726722
Nephropathy 27.85 27.69 19 19357 927 1726478
Conduction disorder 27.81 27.69 14 19362 384 1727021
Aneurysm ruptured 27.79 27.69 11 19365 167 1727238
Sensory loss 27.78 27.69 18 19358 805 1726600

Pharmacologic Action:

SourceCodeDescription
ATC A01AD05 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Other agents for local oral treatment
ATC B01AC06 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC N02BA01 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC B01AC56 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC C07FX02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX04 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C10BX01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC M01BA03 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY/ANTIRHEUMATIC AGENTS IN COMBINATION
Antiinflammatory/antirheumatic agents in combination with corticosteroids
ATC N02AJ02 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ07 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ18 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02BA51 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA71 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
FDA PE N0000008836 Decreased Prostaglandin Production
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
FDA PE N0000008832 Decreased Platelet Aggregation
FDA Chemical/Ingredient N0000175721 Nonsteroidal Anti-inflammatory Compounds
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:73182 plant activator
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:50427 platelet aggregation inhibitor
CHEBI has role CHEBI:35493 antipyretic
CHEBI has role CHEBI:49023 prostaglandin antagonist
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D058633 Antipyretics
MeSH PA D018501 Antirheumatic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Pain indication 22253000
Myocardial infarction indication 22298006 DOID:5844
Toothache indication 27355003
Migraine indication 37796009 DOID:6364
Joint pain indication 57676002
Rheumatoid arthritis indication 69896004 DOID:7148
Common cold indication 82272006 DOID:10459
Backache indication 161891005
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Osteoarthritis indication 396275006
Arthritic Pain indication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.57 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9101637 March 23, 2022 TEMPORARY REDUCTION OF FEVER
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9101637 March 23, 2022 TEMPORARY RELIEF OF MINOR ACHES AND PAINS
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9101637 March 23, 2022 TREATMENT/PREVENTION OF CARDIOVASCULAR DISEASE
325MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 9364439 May 31, 2022 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 9364439 May 31, 2022 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 6926907 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 8206741 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 6926907 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 8206741 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TEMPORARY REDUCTION OF FEVER
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TEMPORARY RELIEF OF MINOR ACHES AND PAINS
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TREATMENT/PREVENTION OF CARDIOVASCULAR DISEASE
325MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 RX TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.77 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5.12 WOMBAT-PK CHEMBL
Gamma-glutamyltranspeptidase 1 Enzyme IC50 4.44 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.62 CHEMBL
Acidic phospholipase A2 3 Enzyme Kd 5.20 WOMBAT-PK
Prostaglandin G/H synthase 1 Enzyme IC50 6.52 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.46 CHEMBL

External reference:

IDSource
D001241 MESH_DESCRIPTOR_UI
4017536 VUID
N0000145918 NUI
C0004057 UMLSCUI
D00109 KEGG_DRUG
4995924SMK UNII
132-49-0 SECONDARY_CAS_RN
7947003 SNOMEDCT_US
4017536 VANDF
34512 MMSL
001587 NDDF
244 MMSL
1191 RXNORM
387458008 SNOMEDCT_US
4223 MMSL
d00170 MMSL
2244 PUBCHEM_CID
CHEBI:15365 CHEBI
CHEMBL25 ChEMBL_ID
DB00945 DRUGBANK_ID
AIN PDB_CHEM_ID
4139 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fiorinal with Codeine HUMAN PRESCRIPTION DRUG LABEL 4 0023-6010 CAPSULE 325 mg ORAL NDA 20 sections
Fiorinal HUMAN PRESCRIPTION DRUG LABEL 3 0023-6146 CAPSULE 325 mg ORAL NDA 12 sections
Excedrin HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 9 sections
Excedrin HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 9 sections
Excedrin HUMAN OTC DRUG LABEL 3 0067-2021 TABLET, COATED 250 mg ORAL OTC monograph not final 9 sections
Excedrin HUMAN OTC DRUG LABEL 3 0067-2035 TABLET, COATED 250 mg ORAL NDA 10 sections
EXCEDRIN HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 250 mg ORAL NDA 9 sections
Excedrin PM Triple Action Caplets HUMAN OTC DRUG LABEL 3 0067-2056 TABLET, COATED 250 mg ORAL OTC monograph not final 9 sections
Excedrin PM Triple Action Caplets and Excedrin Tension Headache HUMAN OTC DRUG LABEL 5 0067-8147 KIT 250 mg None OTC monograph not final 9 sections
Excedrin PM Triple Action Caplets and Excedrin Extra Strength Pain Reliever HUMAN OTC DRUG LABEL 6 0067-8148 KIT 250 mg None OTC monograph not final 9 sections
Excedrin PM Triple Action Caplets and Excedrin Extra Strength Pain Reliever HUMAN OTC DRUG LABEL 6 0067-8148 KIT 250 mg None OTC monograph not final 9 sections
Excedrin Extra Strength and Excedrin Tension Headache HUMAN OTC DRUG LABEL 5 0067-8151 KIT 250 mg None OTC monograph not final 9 sections
EXCEDRIN HUMAN OTC DRUG LABEL 3 0067-8201 TABLET, FILM COATED 250 mg ORAL NDA 9 sections
Excedrin HUMAN OTC DRUG LABEL 3 0067-8202 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 9 sections
Aspirin and Dipyridamole HUMAN PRESCRIPTION DRUG LABEL 2 0093-3064 CAPSULE, EXTENDED RELEASE 25 mg ORAL ANDA 18 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0259 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 9 sections
Good Sense aspirin HUMAN OTC DRUG LABEL 1 0113-0274 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 9 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-0374 TABLET, FILM COATED 250 mg ORAL ANDA 9 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0416 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 9 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0467 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 9 sections
Basic Care Aspirin HUMAN OTC DRUG LABEL 1 0113-0773 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 9 sections
basic care migraine relief HUMAN OTC DRUG LABEL 3 0113-7374 TABLET, FILM COATED 250 mg ORAL ANDA 9 sections
basic care aspirin HUMAN OTC DRUG LABEL 1 0113-7467 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 9 sections
Alka-Seltzer Plus Severe Cold Powerfast Fizz Night HUMAN OTC DRUG LABEL 4 0280-0021 TABLET, EFFERVESCENT 500 mg ORAL OTC monograph final 9 sections
Alka-Seltzer Plus Severe Cold PowerFast Fizz Non Drowsy HUMAN OTC DRUG LABEL 3 0280-0024 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 9 sections
BAYER 500 mg HUMAN OTC DRUG LABEL 1 0280-0029 POWDER 500 mg ORAL Export only 2 sections
Alka-Seltzer Extra Strength HUMAN OTC DRUG LABEL 3 0280-0211 GRANULE, EFFERVESCENT 500 mg ORAL OTC monograph not final 9 sections
Alka-Seltzer Plus Cold Medicine Sparkling Original HUMAN OTC DRUG LABEL 3 0280-1400 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph not final 9 sections
Alka-Seltzer Plus Cold Orange Zest HUMAN OTC DRUG LABEL 3 0280-1510 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 17 sections
Alka-Seltzer Plus Cold Sparkling Original HUMAN OTC DRUG LABEL 3 0280-1520 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 17 sections