celecoxib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
selective cyclo-oxygenase inhibitors	568	169590-42-5

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: celecoxib celebrex celecox celocoxib onsenal

A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN. Molecular weight: 381.37 Formula: C17H14F3N3O2S CLOGP: 4.37 LIPINSKI: 0 HAC: 5 HDO: 1 TPSA: 77.98 ALOGS: -4.88 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.01 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	2 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	17.49 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Dec. 31, 1998	FDA	GD SEARLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	6894.59	22.90	1971	7159	44672	2304283
Drug ineffective	2726.64	22.90	1225	7905	100399	2248556
Rheumatoid arthritis	1464.91	22.90	499	8631	18641	2330314
Pain	993.64	22.90	532	8598	61325	2287630
Condition aggravated	870.89	22.90	395	8735	31584	2317371
Arthralgia	806.37	22.90	444	8686	53841	2295114
Rash	738.53	22.90	433	8697	59125	2289830
Drug intolerance	689.79	22.90	263	8867	13454	2335501
Therapeutic product effect decreased	589.70	22.90	220	8910	10569	2338386
Nausea	586.65	22.90	479	8651	111710	2237245
Loss of personal independence in daily activities	509.81	22.90	165	8965	5146	2343809
Therapeutic product effect incomplete	507.70	22.90	196	8934	10335	2338620
Pain in extremity	470.18	22.90	288	8842	42252	2306703
Arthropathy	424.42	22.90	156	8974	7160	2341795
Gastrointestinal haemorrhage	422.31	22.90	180	8950	12255	2336700
Myocardial infarction	408.31	22.90	200	8930	18813	2330142
Contraindicated product administered	399.53	22.90	120	9010	2901	2346054
Joint swelling	379.33	22.90	183	8947	16636	2332319
Hypersensitivity	367.54	22.90	200	8930	23393	2325562
Swelling	365.98	22.90	177	8953	16173	2332782
Abdominal discomfort	363.89	22.90	180	8950	17276	2331679
Vomiting	353.87	22.90	297	8833	71305	2277650
Pruritus	340.08	22.90	237	8893	43103	2305852
Urticaria	326.89	22.90	187	8943	24074	2324881
Diarrhoea	323.85	22.90	302	8828	83262	2265693
Arthritis	314.29	22.90	137	8993	9831	2339124
Malaise	306.57	22.90	246	8884	55339	2293616
Osteoarthritis	301.69	22.90	120	9010	6826	2342129
Anaphylactic reaction	291.74	22.90	129	9001	9576	2339379
Infection	283.76	22.90	154	8976	17875	2331080
Musculoskeletal stiffness	281.18	22.90	135	8995	12112	2336843
Gait disturbance	280.31	22.90	165	8965	22380	2326575
Dyspnoea	277.12	22.90	270	8860	78463	2270492
Drug interaction	255.69	22.90	171	8959	28992	2319963
Abdominal pain upper	254.54	22.90	154	8976	21946	2327009
Acute kidney injury	244.36	22.90	164	8966	27958	2320997
International normalised ratio fluctuation	243.92	22.90	52	9078	279	2348676
Renal impairment	243.04	22.90	115	9015	9977	2338978
Gastric disorder	236.90	22.90	85	9045	3625	2345330
Hypertension	236.36	22.90	159	8971	27202	2321753
Mobility decreased	235.75	22.90	108	9022	8702	2340253
Atrial fibrillation	234.47	22.90	124	9006	13644	2335311
Osteoporosis	233.34	22.90	88	9042	4326	2344629
Chest pain	229.95	22.90	158	8972	27979	2320976
Treatment failure	229.71	22.90	100	9030	7139	2341816
Gastric ulcer	222.72	22.90	77	9053	2939	2346016
Fall	220.91	22.90	190	8940	46909	2302046
Drug eruption	220.69	22.90	78	9052	3181	2345774
Dizziness	216.95	22.90	207	8923	58458	2290497
Erythema	216.76	22.90	146	8984	25013	2323942
Bedridden	211.50	22.90	62	9068	1370	2347585
Back pain	208.68	22.90	156	8974	31503	2317452
Hypoaesthesia	205.11	22.90	130	9000	20085	2328870
Insomnia	204.04	22.90	142	8988	25645	2323310
Presbyacusis	196.03	22.90	33	9097	27	2348928
Headache	191.35	22.90	224	8906	79955	2269000
Asthenia	185.61	22.90	172	8958	46754	2302201
Stress	182.26	22.90	84	9046	6854	2342101
Oedema peripheral	181.30	22.90	128	9002	23635	2325320
Gastrooesophageal reflux disease	180.96	22.90	91	9039	9004	2339951
Muscle spasms	178.17	22.90	122	9008	21444	2327511
Renal failure	169.54	22.90	109	9021	17240	2331715
Fatigue	160.42	22.90	211	8919	84662	2264293
Anaemia	158.12	22.90	138	8992	34654	2314301
Cerebrovascular accident	156.86	22.90	110	9020	20076	2328879
Pleural fibrosis	156.21	22.90	33	9097	168	2348787
Peripheral swelling	155.93	22.90	104	9026	17493	2331462
Nasopharyngitis	154.88	22.90	113	9017	21943	2327012
Immobile	152.91	22.90	40	9090	569	2348386
Gastrointestinal disorder	150.81	22.90	80	9050	8837	2340118
Pneumonia	148.87	22.90	156	8974	49140	2299815
Gastric ulcer haemorrhage	144.68	22.90	41	9089	799	2348156
Weight decreased	144.12	22.90	120	9010	28251	2320704
Abdominal pain	143.56	22.90	130	9000	34244	2314711
Fibromyalgia	143.11	22.90	57	9073	3243	2345712
Feeling abnormal	141.56	22.90	110	9020	23471	2325484
Intentional product misuse	137.89	22.90	77	9053	9412	2339543
Blood cholesterol increased	136.20	22.90	63	9067	5178	2343777
Nerve injury	133.47	22.90	41	9089	1067	2347888
Dyspepsia	132.57	22.90	76	9054	9768	2339187
Pleural thickening	131.72	22.90	25	9105	64	2348891
Deafness neurosensory	128.47	22.90	34	9096	507	2348448
Blood creatinine increased	127.79	22.90	76	9054	10457	2338498
Weight increased	127.15	22.90	101	9029	22236	2326719
Swelling face	127.05	22.90	73	9057	9420	2339535
Depression	126.56	22.90	111	9019	28021	2320934
Lower limb fracture	126.50	22.90	46	9084	2035	2346920
Pharyngeal oedema	126.41	22.90	53	9077	3440	2345515
Blood pressure increased	125.98	22.90	90	9040	16896	2332059
Nephrolithiasis	125.54	22.90	57	9073	4486	2344469
Loss of consciousness	124.62	22.90	93	9037	18674	2330281
Gait inability	122.57	22.90	61	9069	5894	2343061
Deformity	121.68	22.90	32	9098	465	2348490
Haematemesis	121.67	22.90	54	9076	4028	2344927
Sleep disorder	120.50	22.90	62	9068	6427	2342528
Foot fracture	119.51	22.90	48	9082	2790	2346165
Pyrexia	117.81	22.90	144	8986	53564	2295391
Arrhythmia	116.01	22.90	59	9071	5969	2342986
Paraesthesia	115.39	22.90	95	9035	21993	2326962
Cough	114.79	22.90	113	9017	33004	2315951
Osteopenia	114.74	22.90	42	9088	1893	2347062
Oedema	114.42	22.90	70	9060	10133	2338822
Swollen tongue	113.73	22.90	56	9074	5287	2343668
Dry eye	113.64	22.90	51	9079	3905	2345050
Anaphylactic shock	112.85	22.90	52	9078	4234	2344721
Interstitial lung disease	112.41	22.90	63	9067	7749	2341206
General physical health deterioration	111.98	22.90	78	9052	14061	2334894
Blood magnesium increased	109.71	22.90	24	9106	148	2348807
Cardiac disorder	109.54	22.90	62	9068	7771	2341184
Gastritis	109.54	22.90	52	9078	4529	2344426
Stevens-Johnson syndrome	106.93	22.90	50	9080	4209	2344746
Blood potassium increased	106.00	22.90	41	9089	2155	2346800
Body height decreased	104.57	22.90	35	9095	1206	2347749
Epigastric discomfort	104.32	22.90	29	9101	525	2348430
Epicondylitis	103.80	22.90	25	9105	248	2348707
Foot deformity	102.68	22.90	39	9091	1950	2347005
Renal disorder	101.40	22.90	49	9081	4439	2344516
Confusional state	99.44	22.90	91	9039	24253	2324702
Melaena	99.37	22.90	47	9083	4059	2344896
Erythema multiforme	99.29	22.90	39	9091	2136	2346819
Palpitations	99.19	22.90	77	9053	16379	2332576
Impaired work ability	98.91	22.90	37	9093	1773	2347182
Inflammation	97.33	22.90	53	9077	6160	2342795
Contusion	95.24	22.90	68	9062	12742	2336213
Upper limb fracture	94.13	22.90	40	9090	2683	2346272
Back disorder	91.72	22.90	34	9096	1588	2347367
Haemorrhage	89.97	22.90	62	9068	10977	2337978
Fine motor skill dysfunction	89.96	22.90	23	9107	297	2348658
Migraine	89.59	22.90	61	9069	10592	2338363
Cyst	88.64	22.90	33	9097	1560	2347395
Haemoglobin decreased	88.41	22.90	75	9055	18076	2330879
Hypotension	87.81	22.90	97	9033	32339	2316616
Musculoskeletal pain	86.32	22.90	60	9070	10770	2338185
Pulmonary fibrosis	85.39	22.90	37	9093	2603	2346352
Alanine aminotransferase increased	85.29	22.90	66	9064	13966	2334989
Bloody discharge	85.14	22.90	19	9111	130	2348825
Completed suicide	84.65	22.90	78	9052	20956	2327999
Fracture	84.18	22.90	37	9093	2694	2346261
Aspartate aminotransferase increased	82.55	22.90	62	9068	12550	2336405
Skin lesion	82.13	22.90	41	9089	3984	2344971
Exostosis	82.03	22.90	30	9100	1348	2347607
Disease recurrence	81.97	22.90	39	9091	3412	2345543
Anxiety	81.53	22.90	89	9041	29270	2319685
Ankylosing spondylitis	80.56	22.90	25	9105	673	2348282
Ulcer	79.84	22.90	32	9098	1848	2347107
Neck pain	79.17	22.90	50	9080	7647	2341308
Cataract	77.86	22.90	45	9085	5863	2343092
Off label use	77.74	22.90	140	8990	73458	2275497
Thyroid neoplasm	77.55	22.90	24	9106	640	2348315
Toxic skin eruption	77.45	22.90	33	9097	2227	2346728
Bone erosion	76.97	22.90	23	9107	543	2348412
Movement disorder	76.59	22.90	35	9095	2793	2346162
Bone cyst	76.50	22.90	18	9112	160	2348795
Drug-induced liver injury	76.42	22.90	38	9092	3661	2345294
Hypermobility syndrome	75.82	22.90	14	9116	29	2348926
Rectal haemorrhage	75.57	22.90	44	9086	5812	2343143
C-reactive protein increased	75.48	22.90	45	9085	6210	2342745
Constipation	75.23	22.90	74	9056	21555	2327400
Lyme disease	74.78	22.90	21	9109	395	2348560
Transient ischaemic attack	74.73	22.90	44	9086	5934	2343021
Gastric haemorrhage	73.81	22.90	26	9104	1047	2347908
Upper gastrointestinal haemorrhage	73.45	22.90	31	9099	2043	2346912
Product use issue	71.26	22.90	56	9074	12113	2336842
Face oedema	71.19	22.90	37	9093	3911	2345044
Asthma	70.46	22.90	54	9076	11260	2337695
Hyperkalaemia	70.07	22.90	42	9088	5851	2343104
Joint range of motion decreased	69.95	22.90	29	9101	1827	2347128
Osteosclerosis	69.18	22.90	19	9111	328	2348627
Dehydration	67.90	22.90	71	9059	22224	2326731
Rotator cuff syndrome	67.05	22.90	28	9102	1797	2347158
Rash erythematous	66.96	22.90	41	9089	5935	2343020
Somnolence	66.58	22.90	72	9058	23413	2325542
Diverticulitis	66.53	22.90	36	9094	4129	2344826
Respiratory tract congestion	66.24	22.90	30	9100	2344	2346611
Dermatitis	66.17	22.90	30	9100	2350	2346605
Cardiac arrest	65.22	22.90	58	9072	14872	2334083
C-reactive protein abnormal	65.20	22.90	22	9108	777	2348178
Cerebral infarction	64.39	22.90	36	9094	4401	2344554
Red blood cell sedimentation rate increased	62.79	22.90	28	9102	2109	2346846
Coronary artery occlusion	62.53	22.90	24	9106	1234	2347721
Angina pectoris	62.40	22.90	34	9096	3953	2345002
Burning sensation	61.50	22.90	43	9087	7785	2341170
Neuralgia	61.29	22.90	30	9100	2792	2346163
Crohn's disease	60.47	22.90	40	9090	6615	2342340
Chest discomfort	60.40	22.90	55	9075	14540	2334415
Intervertebral disc degeneration	60.16	22.90	25	9105	1584	2347371
Shock	59.51	22.90	33	9097	3971	2344984
Intervertebral disc protrusion	59.17	22.90	30	9100	3011	2345944
Dysphagia	58.43	22.90	51	9079	12754	2336201
Bone swelling	58.01	22.90	15	9115	203	2348752
Tremor	57.96	22.90	63	9067	20598	2328357
Therapeutic response decreased	57.64	22.90	40	9090	7155	2341800
Bunion operation	57.23	22.90	14	9116	149	2348806
Neoplasm malignant	57.21	22.90	35	9095	5058	2343897
Glaucoma	56.95	22.90	26	9104	2069	2346886
Synovitis	56.29	22.90	28	9102	2698	2346257
Purpura senile	56.21	22.90	10	9120	15	2348940
Haematochezia	55.95	22.90	35	9095	5260	2343695
Coma	55.89	22.90	43	9087	9013	2339942
Diverticulum	55.37	22.90	23	9107	1456	2347499
Blister	55.08	22.90	38	9092	6733	2342222
Hepatic enzyme increased	55.00	22.90	44	9086	9758	2339197
Myalgia	55.00	22.90	65	9065	23268	2325687
Toxicity to various agents	54.83	22.90	77	9053	32677	2316278
Vertigo	54.53	22.90	43	9087	9341	2339614
Dysstasia	54.30	22.90	28	9102	2911	2346044
Urinary retention	53.88	22.90	30	9100	3637	2345318
Photosensitivity reaction	53.31	22.90	26	9104	2401	2346554
Herpes zoster	53.18	22.90	43	9087	9682	2339273
White blood cell count abnormal	51.76	22.90	18	9112	697	2348258
Discomfort	51.76	22.90	33	9097	5126	2343829
Diabetes mellitus	51.60	22.90	38	9092	7457	2341498
Urinary tract infection	51.02	22.90	71	9059	29871	2319084
Purpura	50.90	22.90	23	9107	1787	2347168
Cardiac failure	50.87	22.90	46	9084	12048	2336907
Blood pressure decreased	50.84	22.90	41	9089	9195	2339760
Rheumatoid nodule	50.36	22.90	17	9113	601	2348354
Tachycardia	49.48	22.90	52	9078	16357	2332598
Road traffic accident	49.39	22.90	30	9100	4278	2344677
Chronic obstructive pulmonary disease	48.99	22.90	36	9094	7041	2341914
Knee arthroplasty	48.63	22.90	26	9104	2909	2346046
Abdominal distension	48.57	22.90	42	9088	10369	2338586
Product prescribing error	48.43	22.90	26	9104	2934	2346021
Product use in unapproved indication	47.89	22.90	43	9087	11157	2337798
Lower respiratory tract infection	47.82	22.90	32	9098	5392	2343563
Embolism	47.74	22.90	20	9110	1293	2347662
Liver disorder	47.52	22.90	34	9096	6380	2342575
Heart rate irregular	47.38	22.90	24	9106	2403	2346552
Rash maculo-papular	47.19	22.90	29	9101	4223	2344732
Agranulocytosis	47.14	22.90	27	9103	3455	2345500
Cardiac failure congestive	46.73	22.90	50	9080	16051	2332904
Cystitis	46.68	22.90	32	9098	5610	2343345
Musculoskeletal disorder	46.46	22.90	24	9106	2504	2346451
Eye disorder	46.38	22.90	26	9104	3193	2345762
Memory impairment	46.37	22.90	45	9085	12878	2336077
Candida infection	46.34	22.90	25	9105	2848	2346107
Muscular weakness	46.33	22.90	48	9082	14849	2334106
Kounis syndrome	46.07	22.90	13	9117	249	2348706
Procedural haemorrhage	45.77	22.90	15	9115	483	2348472
Angioedema	45.64	22.90	37	9093	8359	2340596
Red blood cell sedimentation rate abnormal	45.05	22.90	15	9115	508	2348447
Treatment noncompliance	44.87	22.90	31	9099	5503	2343452
Hiatus hernia	44.79	22.90	22	9108	2062	2346893
Tarsal tunnel syndrome	44.77	22.90	9	9121	34	2348921
Pancreatitis	44.76	22.90	36	9094	8043	2340912
Mouth ulceration	44.23	22.90	27	9103	3885	2345070
Colitis	44.09	22.90	30	9100	5196	2343759
Dry mouth	44.08	22.90	36	9094	8217	2340738
Hepatic steatosis	43.73	22.90	25	9105	3188	2345767
Duodenal ulcer	43.70	22.90	18	9112	1115	2347840
Impaired healing	43.14	22.90	30	9100	5381	2343574
Spinal stenosis	43.01	22.90	19	9111	1399	2347556
Pulmonary congestion	43.00	22.90	21	9109	1944	2347011
Cardio-respiratory arrest	42.87	22.90	37	9093	9109	2339846
Blood alkaline phosphatase increased	42.41	22.90	32	9098	6513	2342442
Faeces discoloured	42.21	22.90	22	9108	2337	2346618
Dermatitis allergic	42.15	22.90	21	9109	2030	2346925
Coronary artery stenosis	42.01	22.90	16	9114	805	2348150
Metabolic surgery	41.93	22.90	11	9119	158	2348797
Hepatitis	41.10	22.90	31	9099	6306	2342649
Post procedural haemorrhage	40.93	22.90	18	9112	1311	2347644
Groin pain	40.66	22.90	18	9112	1332	2347623
Speech disorder	40.55	22.90	31	9099	6433	2342522
Rash pruritic	40.52	22.90	33	9097	7502	2341453
Platelet count decreased	40.51	22.90	46	9084	15767	2333188
Scar	40.50	22.90	20	9110	1897	2347058
Peritonitis	40.41	22.90	22	9108	2552	2346403
Ventricular extrasystoles	40.02	22.90	20	9110	1946	2347009
Substance-induced psychotic disorder	39.58	22.90	12	9118	298	2348657
International normalised ratio increased	39.18	22.90	32	9098	7304	2341651
Spinal osteoarthritis	39.12	22.90	19	9111	1738	2347217
Dysarthria	39.04	22.90	30	9100	6272	2342683
Deep vein thrombosis	39.01	22.90	41	9089	12891	2336064
Throat tightness	38.69	22.90	26	9104	4410	2344545
Joint stiffness	38.54	22.90	25	9105	3998	2344957
Gallbladder disorder	38.43	22.90	22	9108	2812	2346143
Product substitution issue	37.85	22.90	27	9103	5042	2343913
Emphysema	37.69	22.90	16	9114	1069	2347886
Hand deformity	37.68	22.90	16	9114	1070	2347885
Frequent bowel movements	37.20	22.90	19	9111	1935	2347020
Alopecia	37.20	22.90	52	9078	21949	2327006
Influenza	37.12	22.90	40	9090	12938	2336017
Oral candidiasis	37.10	22.90	19	9111	1946	2347009
Hypoacusis	37.09	22.90	23	9107	3402	2345553
Liver function test abnormal	36.53	22.90	31	9099	7459	2341496
Hyperhidrosis	36.38	22.90	43	9087	15379	2333576
Toxic epidermal necrolysis	36.31	22.90	22	9108	3122	2345833
Generalised oedema	36.24	22.90	20	9110	2383	2346572
Blood urea increased	36.01	22.90	23	9107	3582	2345373
Adverse drug reaction	35.80	22.90	32	9098	8251	2340704
Ulcer haemorrhage	35.79	22.90	13	9117	572	2348383
Stomatitis	35.18	22.90	34	9096	9676	2339279
Disturbance in attention	35.08	22.90	27	9103	5658	2343297
Thrombocytopenia	35.03	22.90	47	9083	19084	2329871
Haemorrhage subcutaneous	34.58	22.90	13	9117	631	2348324
Lactic acidosis	34.40	22.90	26	9104	5304	2343651
Colitis ischaemic	34.34	22.90	17	9113	1620	2347335
Vasculitis	34.15	22.90	19	9111	2299	2346656
Malignant polyp	34.14	22.90	6	9124	8	2348947
Cardiovascular disorder	33.87	22.90	19	9111	2336	2346619
Jaundice	33.64	22.90	26	9104	5482	2343473
Hepatitis cholestatic	33.48	22.90	15	9115	1142	2347813
Eczema	33.39	22.90	21	9109	3184	2345771
Thrombosis	33.09	22.90	32	9098	9112	2339843
Gastrointestinal ulcer haemorrhage	33.06	22.90	9	9121	150	2348805
Decreased appetite	33.03	22.90	57	9073	28834	2320121
Lung disorder	32.97	22.90	27	9103	6185	2342770
Cholestasis	32.91	22.90	22	9108	3699	2345256
Back injury	32.90	22.90	14	9116	941	2348014
Musculoskeletal discomfort	32.80	22.90	18	9112	2120	2346835
Limb injury	32.74	22.90	19	9111	2491	2346464
Delirium	32.65	22.90	25	9105	5198	2343757
Hallucination	32.32	22.90	30	9100	8118	2340837
Bursitis	31.88	22.90	17	9113	1891	2347064
Gastroenteritis	31.75	22.90	20	9110	3040	2345915
Vision blurred	31.50	22.90	39	9091	14629	2334326
Visual impairment	31.48	22.90	35	9095	11720	2337235
Heart rate increased	31.36	22.90	34	9096	11071	2337884
Hepatic function abnormal	31.33	22.90	26	9104	6066	2342889
Disease progression	31.30	22.90	42	9088	17053	2331902
Blood pressure systolic increased	31.29	22.90	18	9112	2321	2346634
Gastric perforation	31.25	22.90	10	9120	298	2348657
Antinuclear antibody positive	31.22	22.90	14	9116	1068	2347887
Skin ulcer	31.18	22.90	22	9108	4037	2344918
Acute myocardial infarction	31.17	22.90	24	9106	5031	2343924
Meniscus injury	31.02	22.90	14	9116	1084	2347871
Respiratory arrest	31.01	22.90	26	9104	6152	2342803
Heart rate decreased	30.76	22.90	21	9109	3655	2345300
Spinal fracture	30.70	22.90	19	9111	2800	2346155
Neuropathy peripheral	30.54	22.90	34	9096	11398	2337557
Therapy non-responder	30.53	22.90	29	9101	8075	2340880
Joint destruction	30.36	22.90	10	9120	327	2348628
Syncope	30.20	22.90	41	9089	16834	2332121
Haematocrit decreased	29.96	22.90	22	9108	4296	2344659
Post procedural complication	29.88	22.90	19	9111	2935	2346020
Vestibular disorder	29.78	22.90	9	9121	221	2348734
Type 2 diabetes mellitus	29.66	22.90	17	9113	2177	2346778
Balance disorder	29.56	22.90	31	9099	9716	2339239
Loss of employment	29.46	22.90	8	9122	132	2348823
Nerve compression	29.37	22.90	13	9117	961	2347994
Resorption bone increased	29.33	22.90	9	9121	233	2348722
Hip arthroplasty	29.21	22.90	16	9114	1878	2347077
Ankle fracture	29.16	22.90	17	9113	2248	2346707
Hyperlipidaemia	29.06	22.90	18	9112	2656	2346299
Economic problem	28.88	22.90	10	9120	382	2348573
Liver injury	28.82	22.90	17	9113	2297	2346658
Ulcerative keratitis	28.74	22.90	11	9119	561	2348394
Tinnitus	28.69	22.90	23	9107	5112	2343843
Chronic kidney disease	28.61	22.90	21	9109	4097	2344858
Chromaturia	28.58	22.90	18	9112	2735	2346220
Duodenal ulcer haemorrhage	28.35	22.90	10	9120	404	2348551
Hysterectomy	28.33	22.90	15	9115	1645	2347310
Pleural effusion	28.29	22.90	33	9097	11635	2337320
Cholelithiasis	28.26	22.90	24	9106	5779	2343176
Joint injury	28.09	22.90	17	9113	2407	2346548
Iron deficiency	28.07	22.90	11	9119	598	2348357
Pruritus allergic	28.07	22.90	8	9122	159	2348796
Sinusitis	27.84	22.90	39	9091	16487	2332468
Wrist fracture	27.81	22.90	15	9115	1708	2347247
Coronary artery disease	27.77	22.90	24	9106	5915	2343040
Disseminated intravascular coagulation	27.70	22.90	19	9111	3331	2345624
Infusion related reaction	27.67	22.90	30	9100	9766	2339189
Seizure	27.60	22.90	48	9082	24418	2324537
Limb discomfort	27.56	22.90	19	9111	3360	2345595
Erosive oesophagitis	27.51	22.90	9	9121	288	2348667
Livedo reticularis	27.43	22.90	10	9120	445	2348510
Drug ineffective for unapproved indication	27.35	22.90	18	9112	2948	2346007
Influenza like illness	27.29	22.90	33	9097	12081	2336874
Kidney infection	27.18	22.90	17	9113	2552	2346403
Rib fracture	27.08	22.90	17	9113	2568	2346387
Hepatotoxicity	27.05	22.90	19	9111	3462	2345493
Miliaria	26.68	22.90	8	9122	191	2348764
Hepatocellular injury	26.65	22.90	20	9110	4035	2344920
Bone marrow failure	26.64	22.90	23	9107	5663	2343292
Haematoma	26.63	22.90	22	9108	5099	2343856
Transaminases increased	26.60	22.90	21	9109	4566	2344389
Dementia	26.51	22.90	17	9113	2664	2346291
Overdose	26.40	22.90	42	9088	19865	2329090
Gastrointestinal ulcer	26.14	22.90	9	9121	338	2348617
Scoliosis	26.08	22.90	12	9118	972	2347983
Sepsis	25.90	22.90	40	9090	18448	2330507
Urinary incontinence	25.89	22.90	20	9110	4213	2344742
Cardiac murmur	25.61	22.90	14	9116	1637	2347318
Diverticulum intestinal haemorrhagic	25.57	22.90	8	9122	221	2348734
Carpal tunnel syndrome	25.54	22.90	15	9115	2010	2346945
Amnesia	25.52	22.90	25	9105	7228	2341727
Pancytopenia	25.48	22.90	31	9099	11421	2337534
Vertigo positional	25.41	22.90	9	9121	368	2348587
Vitreous detachment	25.25	22.90	9	9121	375	2348580
Vitamin D decreased	25.21	22.90	12	9118	1049	2347906
Pulmonary oedema	25.21	22.90	25	9105	7338	2341617
Erythema nodosum	25.17	22.90	11	9119	789	2348166
Chills	25.16	22.90	36	9094	15516	2333439
Surgery	25.14	22.90	22	9108	5513	2343442
Iron deficiency anaemia	25.04	22.90	15	9115	2084	2346871
Inflammatory bowel disease	25.01	22.90	10	9120	573	2348382
Product dispensing error	24.85	22.90	16	9114	2525	2346430
Lung neoplasm malignant	24.56	22.90	17	9113	3025	2345930
Pain in jaw	24.38	22.90	23	9107	6349	2342606
Irritable bowel syndrome	24.18	22.90	14	9116	1827	2347128
Blood triglycerides increased	24.13	22.90	15	9115	2228	2346727
Dermatitis bullous	24.01	22.90	13	9117	1491	2347464
Urine output decreased	23.89	22.90	13	9117	1506	2347449
Cyanosis	23.85	22.90	17	9113	3168	2345787
Pulmonary embolism	23.77	22.90	38	9092	18045	2330910
Adrenal suppression	23.68	22.90	7	9123	159	2348796
Enthesopathy	23.64	22.90	7	9123	160	2348795
Colitis microscopic	23.51	22.90	11	9119	925	2348030
Colitis ulcerative	23.43	22.90	16	9114	2786	2346169
Haematuria	23.40	22.90	19	9111	4299	2344656
Poor quality sleep	23.32	22.90	14	9116	1953	2347002
Encephalitis brain stem	23.26	22.90	5	9125	28	2348927
Medication error	23.21	22.90	22	9108	6109	2342846
No adverse event	23.18	22.90	27	9103	9501	2339454
Pancreatitis acute	23.12	22.90	18	9112	3835	2345120
Flushing	23.01	22.90	30	9100	11841	2337114
Tubulointerstitial nephritis	22.98	22.90	15	9115	2423	2346532

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	1339.96	22.81	407	3652	14728	1727994
Drug ineffective	409.60	22.81	272	3787	63529	1679193
Myocardial infarction	317.38	22.81	171	3888	27003	1715719
Gastrointestinal haemorrhage	302.36	22.81	135	3924	14132	1728590
Rash	253.94	22.81	168	3891	38525	1704197
Pain	204.75	22.81	128	3931	26529	1716193
Pruritus	164.38	22.81	106	3953	23116	1719606
Chest pain	163.79	22.81	100	3959	19814	1722908
Rheumatoid arthritis	163.28	22.81	63	3996	4522	1738200
Acute kidney injury	159.83	22.81	122	3937	34822	1707900
Ankylosing spondylitis	149.90	22.81	39	4020	754	1741968
Cerebrovascular accident	142.45	22.81	88	3971	17778	1724944
Arthralgia	139.27	22.81	96	3963	23348	1719374
Asthenia	134.67	22.81	110	3949	34560	1708162
Condition aggravated	114.80	22.81	82	3977	21068	1721654
Dyspnoea	112.34	22.81	119	3940	51940	1690782
Loss of personal independence in daily activities	111.10	22.81	40	4019	2359	1740363
Nausea	110.41	22.81	117	3942	51079	1691643
Atrial fibrillation	106.76	22.81	69	3990	15042	1727680
Dizziness	102.82	22.81	94	3965	34267	1708455
Erythema	100.74	22.81	65	3994	14123	1728599
Abdominal discomfort	99.40	22.81	55	4004	9026	1733696
Urticaria	99.23	22.81	61	3998	12180	1730542
Hypersensitivity	97.49	22.81	57	4002	10387	1732335
Anaemia	94.81	22.81	84	3975	29373	1713349
Arthritis	94.78	22.81	41	4018	3934	1738788
Gastric ulcer	88.80	22.81	35	4024	2650	1740072
Pneumonia	88.04	22.81	99	3960	46083	1696639
Hypertension	84.44	22.81	66	3993	19382	1723340
Oedema peripheral	81.31	22.81	59	4000	15491	1727231
Melaena	81.17	22.81	40	4019	5170	1737552
Drug eruption	79.10	22.81	33	4026	2893	1739829
Pain in extremity	78.69	22.81	62	3997	18410	1724312
Osteoarthritis	76.17	22.81	30	4029	2266	1740456
Vomiting	76.14	22.81	84	3975	38231	1704491
Pyrexia	75.92	22.81	92	3967	46308	1696414
Renal failure	74.31	22.81	62	3997	19955	1722767
Drug interaction	73.00	22.81	71	3988	27887	1714835
Anaphylactic reaction	72.32	22.81	39	4020	6074	1736648
Infection	71.75	22.81	50	4009	12310	1730412
Blood pressure increased	70.73	22.81	47	4012	10706	1732016
Knee arthroplasty	68.65	22.81	22	4037	906	1741816
Abdominal pain	68.48	22.81	61	3998	21429	1721293
Therapeutic product effect incomplete	67.93	22.81	36	4023	5412	1737310
Fatigue	67.76	22.81	91	3968	50690	1692032
Renal impairment	67.27	22.81	48	4011	12266	1730456
Haemorrhage	67.16	22.81	44	4015	9785	1732937
Back pain	66.97	22.81	54	4005	16559	1726163
Haematemesis	66.37	22.81	33	4026	4344	1738378
Joint swelling	65.44	22.81	37	4022	6316	1736406
Therapeutic product effect decreased	63.05	22.81	36	4023	6261	1736461
Gastric ulcer haemorrhage	63.04	22.81	21	4038	978	1741744
Transposition of the great vessels	62.69	22.81	14	4045	136	1742586
Abdominal pain upper	62.66	22.81	44	4015	10957	1731765
Acute myocardial infarction	62.50	22.81	40	4019	8547	1734175
Fracture	61.48	22.81	21	4038	1057	1741665
Hypotension	60.55	22.81	66	3993	29588	1713134
Anaphylactic shock	59.73	22.81	27	4032	2872	1739850
Cardiac disorder	58.89	22.81	37	4022	7654	1735068
Malaise	57.24	22.81	64	3995	29501	1713221
Urinary retention	57.13	22.81	32	4027	5363	1737359
Haematochezia	57.02	22.81	31	4028	4901	1737821
Swelling face	56.95	22.81	30	4029	4453	1738269
Diarrhoea	56.36	22.81	86	3973	53766	1688956
Disease recurrence	56.23	22.81	25	4034	2557	1740165
Pulmonary embolism	55.92	22.81	44	4015	13015	1729707
Ependymoma	55.65	22.81	10	4049	26	1742696
Gait disturbance	54.92	22.81	43	4016	12627	1730095
Peptic ulcer	54.30	22.81	16	4043	495	1742227
Interstitial lung disease	53.40	22.81	38	4021	9658	1733064
Cardiac failure	52.96	22.81	42	4017	12560	1730162
Hepatic cirrhosis	52.41	22.81	24	4035	2629	1740093
Transient ischaemic attack	52.31	22.81	29	4030	4762	1737960
Face oedema	52.09	22.81	23	4036	2313	1740409
Swelling	51.92	22.81	33	4026	6963	1735759
Dyspepsia	51.24	22.81	29	4030	4956	1737766
Angina pectoris	51.06	22.81	29	4030	4989	1737733
Loss of consciousness	50.89	22.81	44	4015	14831	1727891
Syncope	50.69	22.81	43	4016	14126	1728596
Arthropathy	50.63	22.81	24	4035	2843	1739879
Hypoaesthesia	50.63	22.81	37	4022	9798	1732924
Stevens-Johnson syndrome	49.97	22.81	25	4034	3332	1739390
Impaired work ability	49.41	22.81	18	4041	1095	1741627
Disease progression	49.08	22.81	46	4013	17217	1725505
Contraindicated product administered	48.35	22.81	19	4040	1425	1741297
Renal disorder	48.11	22.81	26	4033	4060	1738662
Palpitations	47.74	22.81	31	4028	6783	1735939
Product use in unapproved indication	47.49	22.81	35	4024	9387	1733335
Weight decreased	47.02	22.81	51	4008	22702	1720020
Blood pressure fluctuation	46.53	22.81	18	4041	1294	1741428
Coronary artery disease	46.11	22.81	35	4024	9811	1732911
Musculoskeletal pain	45.46	22.81	27	4032	5047	1737675
Faeces discoloured	45.15	22.81	21	4038	2383	1740339
Erythema multiforme	44.85	22.81	19	4040	1727	1740995
Constipation	44.62	22.81	41	4018	14959	1727763
Haemoglobin decreased	43.72	22.81	43	4016	17071	1725651
Upper gastrointestinal haemorrhage	43.65	22.81	22	4037	2977	1739745
Blood creatinine increased	43.20	22.81	39	4020	13907	1728815
Coronary artery occlusion	41.81	22.81	19	4040	2044	1740678
Duodenal ulcer	41.42	22.81	18	4041	1742	1740980
Fall	41.20	22.81	52	4007	27162	1715560
Depression	40.94	22.81	41	4018	16628	1726094
Dehydration	40.76	22.81	42	4017	17616	1725106
Rectal haemorrhage	40.76	22.81	26	4033	5516	1737206
Flushing	40.18	22.81	27	4032	6252	1736470
Ventricular septal defect	39.89	22.81	14	4045	764	1741958
Gastrooesophageal reflux disease	39.74	22.81	24	4035	4623	1738099
Chest expansion decreased	39.29	22.81	7	4052	17	1742705
Headache	38.87	22.81	57	4002	34319	1708403
Arrhythmia	38.81	22.81	26	4033	5990	1736732
Feeling abnormal	38.11	22.81	33	4026	11133	1731589
Paraesthesia	37.94	22.81	32	4027	10419	1732303
Rash erythematous	37.88	22.81	22	4037	3943	1738779
Blood cholesterol increased	37.71	22.81	20	4039	3006	1739716
Hepatic function abnormal	37.27	22.81	27	4032	7047	1735675
Synovitis	36.64	22.81	13	4046	732	1741990
Diverticulitis	36.63	22.81	18	4041	2307	1740415
Osteopenia	36.43	22.81	12	4047	539	1742183
Duodenal ulcer haemorrhage	36.11	22.81	13	4046	764	1741958
Joint range of motion decreased	35.64	22.81	13	4046	793	1741929
C-reactive protein increased	34.55	22.81	24	4035	5861	1736861
Gastrointestinal disorder	34.23	22.81	22	4037	4726	1737996
Inflammatory bowel disease	34.08	22.81	11	4048	463	1742259
Toxic skin eruption	33.97	22.81	16	4043	1867	1740855
Tinnitus	33.94	22.81	19	4040	3176	1739546
Eczema	33.67	22.81	17	4042	2307	1740415
International normalised ratio increased	33.43	22.81	27	4032	8272	1734450
Confusional state	32.73	22.81	41	4018	21237	1721485
Respiratory failure	32.56	22.81	34	4025	14471	1728251
Sepsis	32.39	22.81	39	4020	19399	1723323
Blood urea increased	31.93	22.81	21	4038	4690	1738032
Benign abdominal neoplasm	31.87	22.81	5	4054	3	1742719
Thrombosis	31.43	22.81	25	4034	7496	1735226
Rash maculo-papular	31.33	22.81	19	4040	3684	1739038
Insomnia	31.03	22.81	35	4024	16241	1726481
Neutropenia	31.02	22.81	37	4022	18223	1724499
Liver disorder	30.80	22.81	22	4037	5614	1737108
Lip swelling	30.72	22.81	17	4042	2778	1739944
Coronary artery stenosis	30.26	22.81	14	4045	1568	1741154
Peripheral swelling	30.15	22.81	25	4034	7946	1734776
Cerebral infarction	30.01	22.81	21	4038	5188	1737534
Rhinitis	29.89	22.81	11	4048	688	1742034
Back disorder	29.64	22.81	12	4047	972	1741750
Jaundice	29.36	22.81	22	4037	6040	1736682
Enthesopathy	29.19	22.81	7	4052	95	1742627
Blood pressure decreased	28.96	22.81	24	4035	7622	1735100
Asthma	28.79	22.81	20	4039	4884	1737838
Drug-induced liver injury	28.40	22.81	17	4042	3220	1739502
Drug ineffective for unapproved indication	28.33	22.81	14	4045	1815	1740907
Acute generalised exanthematous pustulosis	28.12	22.81	12	4047	1110	1741612
Malignant neoplasm progression	27.93	22.81	31	4028	14127	1728595
Intentional product misuse	27.67	22.81	23	4036	7335	1735387
Axial spondyloarthritis	27.30	22.81	5	4054	15	1742707
Sudden death	27.25	22.81	16	4043	2924	1739798
Metabolic acidosis	27.05	22.81	20	4039	5382	1737340
Intermittent claudication	26.99	22.81	9	4050	420	1742302
Neuropathy peripheral	26.92	22.81	25	4034	9228	1733494
Hernia	26.85	22.81	12	4047	1240	1741482
Diabetes mellitus	26.82	22.81	22	4037	6886	1735836
Visual impairment	26.69	22.81	21	4038	6197	1736525
Decreased activity	26.44	22.81	10	4049	675	1742047
Gastritis	26.39	22.81	16	4043	3101	1739621
Sacroiliitis	25.94	22.81	7	4052	156	1742566
Lung disorder	25.74	22.81	19	4040	5100	1737622
Duodenal ulcer perforation	25.62	22.81	8	4051	302	1742420
Respiratory distress	25.61	22.81	19	4040	5138	1737584
Crohn's disease	25.28	22.81	18	4041	4569	1738153
Arachnoiditis	24.85	22.81	6	4053	84	1742638
Mitral valve incompetence	24.66	22.81	13	4046	1929	1740793
Anxiety	23.99	22.81	30	4029	15497	1727225
Somnolence	23.74	22.81	31	4028	16708	1726014
Deep vein thrombosis	23.60	22.81	24	4035	9896	1732826
Cardiac arrest	23.37	22.81	30	4029	15900	1726822
Cough	23.36	22.81	33	4026	19164	1723558
Influenza	23.07	22.81	20	4039	6747	1735975
Drug intolerance	22.89	22.81	19	4040	6043	1736679

Pharmacologic Action:

Source	Code	Description
ATC	C08CA51	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives
ATC	L01XX33	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Other antineoplastic agents
ATC	M01AH01	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Coxibs
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D052246	Cyclooxygenase 2 Inhibitors
MeSH PA	D016861	Cyclooxygenase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35481	non-narcotic analgesic
FDA EPC	N0000175722	Nonsteroidal Anti-inflammatory Drug
FDA Chemical/Ingredient	N0000175721	Nonsteroidal Anti-inflammatory Compounds

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Ankylosing spondylitis	indication	9631008	DOID:7147
Rheumatoid arthritis	indication	69896004	DOID:7148
Dysmenorrhea	indication	266599000
Osteoarthritis	indication	396275006
Juvenile rheumatoid arthritis	indication	410795001
Acute postoperative pain	indication	107401000119105
Alcoholism	contraindication	7200002
Peptic ulcer	contraindication	13200003	DOID:750
Myocardial infarction	contraindication	22298006	DOID:5844
Dehydration	contraindication	34095006
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Body fluid retention	contraindication	43498006
Chronic heart failure	contraindication	48447003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Gastrointestinal perforation	contraindication	51875005
Acute nephropathy	contraindication	58574008
Gastrointestinal hemorrhage	contraindication	74474003
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001
Asthma	contraindication	195967001	DOID:2841
Cerebrovascular accident	contraindication	230690007
Coronary artery bypass graft	contraindication	232717009
Disease of liver	contraindication	235856003	DOID:409
Edema	contraindication	267038008
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thromboembolic disorder	contraindication	371039008
Cardiovascular event risk	contraindication	395112001
Smokes tobacco daily	contraindication	449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.79	acidic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
200MG	CONSENSI	COEPTIS	N210045	May 31, 2018	RX	TABLET	ORAL	9662315	May 22, 2029	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
200MG	CONSENSI	COEPTIS	N210045	May 31, 2018	RX	TABLET	ORAL	May 31, 2021	NEW COMBINATION

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	7.24		WOMBAT-PK	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	5.48		DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.14		DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.16		DRUG MATRIX
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN		Ki	4.92		DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6		DRUG MATRIX
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	4.86		DRUG MATRIX
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Enzyme	P27815	PDE4A_HUMAN		IC50	5.03		DRUG MATRIX
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		IC50	7.68		WOMBAT-PK
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	6.18		WOMBAT-PK
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	7.74		CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	6.06		CHEMBL
Carbonic anhydrase 13	Enzyme	Q8N1Q1	CAH13_HUMAN		Ki	7.01		CHEMBL
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	7.30		CHEMBL
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN		Ki	5.13		CHEMBL
3-phosphoinositide-dependent protein kinase 1	Kinase	O15530	PDPK1_HUMAN		IC50	4.32		CHEMBL
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	6.10		CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN		Ki	6.16		CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN		Ki	5.66		CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	4.80		CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	4.30		CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	7.03		CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Ki	7.03		CHEMBL
Mitogen-activated protein kinase 14	Kinase	Q16539	MK14_HUMAN		IC50	6.09		CHEMBL
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	4.85		DRUG MATRIX
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	5.63		DRUG MATRIX
Cytochrome c oxidase subunit 2	Enzyme		COX2_SHEEP		IC50	7.22		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_SHEEP		IC50	8.43		CHEMBL
Carbonic anhydrase	Enzyme		Q50565_METTH		Ki	4.41		CHEMBL
Alpha carbonic anhydrase	Unclassified		B5SU02_9CNID		Ki	7.47		CHEMBL
Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase	Enzyme		P96878_MYCTU		Ki	5.11		CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_SHEEP		IC50	7.40		CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_BOVIN		IC50	7.24		CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_MOUSE		IC50	9.29		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_MOUSE		IC50	9.15		CHEMBL
Astrosclerin-3	Unclassified		A6YCJ1_9METZ		Ki	6.14		CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_RAT		IC50	5.96		CHEMBL
Beta-carbonic anhydrase 1	Enzyme		MTCA1_MYCTU		Ki	4.99		CHEMBL
Carbonic anhydrase	Unclassified		C0IX24_9CNID		Ki	6.16		CHEMBL
Delta carbonic anhydrase	Unclassified		Q5U9J1_THAWE		Ki	6.58		CHEMBL
Carbonic anhydrase	Enzyme		CAN_YEAST		Ki	6.97		CHEMBL
Cyclooxygenase 2; Prostaglandin G/H synthase-2; Uncharacterized protein	Enzyme		Q8SPQ9_CANFA		IC50	6.05		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_CANFA		IC50	5.25		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_RAT		IC50	4.85		CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE		Ki	7.35		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_BOVIN		IC50	5.11		CHEMBL
Cytochrome c oxidase subunit 1	Unclassified		COX1_SHEEP		IC50	4.61		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	7.68		CHEMBL
Carbonic anhydrase	Enzyme		CAH_METTE		Ki	6.85		CHEMBL
Carbonic anhydrase 2	Enzyme		MTCA2_MYCTU		Ki	6.15		CHEMBL
Carbonic anhydrase 4	Enzyme		CAH4_BOVIN		Ki	6.54		CHEMBL
Carbonic anhydrase	Unclassified		Q5TU56_ANOGA		Ki	6.76		CHEMBL
Carbonic anhydrase	Enzyme		Q6FTL6_CANGA		Ki	6.94		CHEMBL

External reference:

ID	Source
D000068579	MESH_DESCRIPTOR_UI
4021143	VUID
N0000148596	NUI
C0538927	UMLSCUI
D00567	KEGG_DRUG
370187009	SNOMEDCT_US
4021143	VANDF
007731	NDDF
174627	MMSL
d04380	MMSL
7872	MMSL
140587	RXNORM
116081000	SNOMEDCT_US
CHEMBL118	ChEMBL_ID
DB00482	DRUGBANK_ID
JCX84Q7J1L	UNII
7767	INN_ID
CEL	PDB_CHEM_ID
CHEBI:41423	CHEBI
2892	IUPHAR_LIGAND_ID
2662	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CELEBREX	HUMAN PRESCRIPTION DRUG LABEL	1	0025-1515	CAPSULE	50 mg	ORAL	NDA	20 sections
CELEBREX	HUMAN PRESCRIPTION DRUG LABEL	1	0025-1520	CAPSULE	100 mg	ORAL	NDA	20 sections
CELEBREX	HUMAN PRESCRIPTION DRUG LABEL	1	0025-1525	CAPSULE	200 mg	ORAL	NDA	20 sections
CELEBREX	HUMAN PRESCRIPTION DRUG LABEL	1	0025-1530	CAPSULE	400 mg	ORAL	NDA	20 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7165	CAPSULE	100 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7166	CAPSULE	200 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7170	CAPSULE	400 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7306	CAPSULE	50 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0378-7150	CAPSULE	200 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0378-7160	CAPSULE	100 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0378-7165	CAPSULE	50 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0378-7170	CAPSULE	400 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3982	CAPSULE	50 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3983	CAPSULE	100 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3984	CAPSULE	200 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3985	CAPSULE	400 mg	ORAL	ANDA	19 sections
celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8297	CAPSULE	200 mg	ORAL	ANDA	19 sections
celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8338	CAPSULE	200 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6502	CAPSULE	100 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6503	CAPSULE	200 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	10544-917	CAPSULE	200 mg	ORAL	NDA authorized generic	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	10544-918	CAPSULE	200 mg	ORAL	NDA authorized generic	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	10544-929	CAPSULE	200 mg	ORAL	NDA authorized generic	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	10544-953	CAPSULE	200 mg	ORAL	ANDA	19 sections
Celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	10544-967	CAPSULE	200 mg	ORAL	NDA authorized generic	19 sections
celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	13668-307	CAPSULE	50 mg	ORAL	ANDA	19 sections
celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	13668-310	CAPSULE	400 mg	ORAL	ANDA	19 sections
celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	13668-441	CAPSULE	100 mg	ORAL	ANDA	19 sections
celecoxib	HUMAN PRESCRIPTION DRUG LABEL	1	13668-442	CAPSULE	200 mg	ORAL	ANDA	19 sections
CELEBREX	HUMAN PRESCRIPTION DRUG LABEL	1	16590-045	CAPSULE	100 mg	ORAL	NDA	19 sections