celecoxib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 568 169590-42-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • celecoxib
  • celebrex
  • celecox
  • celocoxib
  • onsenal
A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN.
  • Molecular weight: 381.37
  • Formula: C17H14F3N3O2S
  • CLOGP: 4.37
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 77.98
  • ALOGS: -4.88
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 17.49 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1998 FDA GD SEARLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 6894.59 22.90 1971 7159 44672 2304283
Drug ineffective 2726.64 22.90 1225 7905 100399 2248556
Rheumatoid arthritis 1464.91 22.90 499 8631 18641 2330314
Pain 993.64 22.90 532 8598 61325 2287630
Condition aggravated 870.89 22.90 395 8735 31584 2317371
Arthralgia 806.37 22.90 444 8686 53841 2295114
Rash 738.53 22.90 433 8697 59125 2289830
Drug intolerance 689.79 22.90 263 8867 13454 2335501
Therapeutic product effect decreased 589.70 22.90 220 8910 10569 2338386
Nausea 586.65 22.90 479 8651 111710 2237245
Loss of personal independence in daily activities 509.81 22.90 165 8965 5146 2343809
Therapeutic product effect incomplete 507.70 22.90 196 8934 10335 2338620
Pain in extremity 470.18 22.90 288 8842 42252 2306703
Arthropathy 424.42 22.90 156 8974 7160 2341795
Gastrointestinal haemorrhage 422.31 22.90 180 8950 12255 2336700
Myocardial infarction 408.31 22.90 200 8930 18813 2330142
Contraindicated product administered 399.53 22.90 120 9010 2901 2346054
Joint swelling 379.33 22.90 183 8947 16636 2332319
Hypersensitivity 367.54 22.90 200 8930 23393 2325562
Swelling 365.98 22.90 177 8953 16173 2332782
Abdominal discomfort 363.89 22.90 180 8950 17276 2331679
Vomiting 353.87 22.90 297 8833 71305 2277650
Pruritus 340.08 22.90 237 8893 43103 2305852
Urticaria 326.89 22.90 187 8943 24074 2324881
Diarrhoea 323.85 22.90 302 8828 83262 2265693
Arthritis 314.29 22.90 137 8993 9831 2339124
Malaise 306.57 22.90 246 8884 55339 2293616
Osteoarthritis 301.69 22.90 120 9010 6826 2342129
Anaphylactic reaction 291.74 22.90 129 9001 9576 2339379
Infection 283.76 22.90 154 8976 17875 2331080
Musculoskeletal stiffness 281.18 22.90 135 8995 12112 2336843
Gait disturbance 280.31 22.90 165 8965 22380 2326575
Dyspnoea 277.12 22.90 270 8860 78463 2270492
Drug interaction 255.69 22.90 171 8959 28992 2319963
Abdominal pain upper 254.54 22.90 154 8976 21946 2327009
Acute kidney injury 244.36 22.90 164 8966 27958 2320997
International normalised ratio fluctuation 243.92 22.90 52 9078 279 2348676
Renal impairment 243.04 22.90 115 9015 9977 2338978
Gastric disorder 236.90 22.90 85 9045 3625 2345330
Hypertension 236.36 22.90 159 8971 27202 2321753
Mobility decreased 235.75 22.90 108 9022 8702 2340253
Atrial fibrillation 234.47 22.90 124 9006 13644 2335311
Osteoporosis 233.34 22.90 88 9042 4326 2344629
Chest pain 229.95 22.90 158 8972 27979 2320976
Treatment failure 229.71 22.90 100 9030 7139 2341816
Gastric ulcer 222.72 22.90 77 9053 2939 2346016
Fall 220.91 22.90 190 8940 46909 2302046
Drug eruption 220.69 22.90 78 9052 3181 2345774
Dizziness 216.95 22.90 207 8923 58458 2290497
Erythema 216.76 22.90 146 8984 25013 2323942
Bedridden 211.50 22.90 62 9068 1370 2347585
Back pain 208.68 22.90 156 8974 31503 2317452
Hypoaesthesia 205.11 22.90 130 9000 20085 2328870
Insomnia 204.04 22.90 142 8988 25645 2323310
Presbyacusis 196.03 22.90 33 9097 27 2348928
Headache 191.35 22.90 224 8906 79955 2269000
Asthenia 185.61 22.90 172 8958 46754 2302201
Stress 182.26 22.90 84 9046 6854 2342101
Oedema peripheral 181.30 22.90 128 9002 23635 2325320
Gastrooesophageal reflux disease 180.96 22.90 91 9039 9004 2339951
Muscle spasms 178.17 22.90 122 9008 21444 2327511
Renal failure 169.54 22.90 109 9021 17240 2331715
Fatigue 160.42 22.90 211 8919 84662 2264293
Anaemia 158.12 22.90 138 8992 34654 2314301
Cerebrovascular accident 156.86 22.90 110 9020 20076 2328879
Pleural fibrosis 156.21 22.90 33 9097 168 2348787
Peripheral swelling 155.93 22.90 104 9026 17493 2331462
Nasopharyngitis 154.88 22.90 113 9017 21943 2327012
Immobile 152.91 22.90 40 9090 569 2348386
Gastrointestinal disorder 150.81 22.90 80 9050 8837 2340118
Pneumonia 148.87 22.90 156 8974 49140 2299815
Gastric ulcer haemorrhage 144.68 22.90 41 9089 799 2348156
Weight decreased 144.12 22.90 120 9010 28251 2320704
Abdominal pain 143.56 22.90 130 9000 34244 2314711
Fibromyalgia 143.11 22.90 57 9073 3243 2345712
Feeling abnormal 141.56 22.90 110 9020 23471 2325484
Intentional product misuse 137.89 22.90 77 9053 9412 2339543
Blood cholesterol increased 136.20 22.90 63 9067 5178 2343777
Nerve injury 133.47 22.90 41 9089 1067 2347888
Dyspepsia 132.57 22.90 76 9054 9768 2339187
Pleural thickening 131.72 22.90 25 9105 64 2348891
Deafness neurosensory 128.47 22.90 34 9096 507 2348448
Blood creatinine increased 127.79 22.90 76 9054 10457 2338498
Weight increased 127.15 22.90 101 9029 22236 2326719
Swelling face 127.05 22.90 73 9057 9420 2339535
Depression 126.56 22.90 111 9019 28021 2320934
Lower limb fracture 126.50 22.90 46 9084 2035 2346920
Pharyngeal oedema 126.41 22.90 53 9077 3440 2345515
Blood pressure increased 125.98 22.90 90 9040 16896 2332059
Nephrolithiasis 125.54 22.90 57 9073 4486 2344469
Loss of consciousness 124.62 22.90 93 9037 18674 2330281
Gait inability 122.57 22.90 61 9069 5894 2343061
Deformity 121.68 22.90 32 9098 465 2348490
Haematemesis 121.67 22.90 54 9076 4028 2344927
Sleep disorder 120.50 22.90 62 9068 6427 2342528
Foot fracture 119.51 22.90 48 9082 2790 2346165
Pyrexia 117.81 22.90 144 8986 53564 2295391
Arrhythmia 116.01 22.90 59 9071 5969 2342986
Paraesthesia 115.39 22.90 95 9035 21993 2326962
Cough 114.79 22.90 113 9017 33004 2315951
Osteopenia 114.74 22.90 42 9088 1893 2347062
Oedema 114.42 22.90 70 9060 10133 2338822
Swollen tongue 113.73 22.90 56 9074 5287 2343668
Dry eye 113.64 22.90 51 9079 3905 2345050
Anaphylactic shock 112.85 22.90 52 9078 4234 2344721
Interstitial lung disease 112.41 22.90 63 9067 7749 2341206
General physical health deterioration 111.98 22.90 78 9052 14061 2334894
Blood magnesium increased 109.71 22.90 24 9106 148 2348807
Cardiac disorder 109.54 22.90 62 9068 7771 2341184
Gastritis 109.54 22.90 52 9078 4529 2344426
Stevens-Johnson syndrome 106.93 22.90 50 9080 4209 2344746
Blood potassium increased 106.00 22.90 41 9089 2155 2346800
Body height decreased 104.57 22.90 35 9095 1206 2347749
Epigastric discomfort 104.32 22.90 29 9101 525 2348430
Epicondylitis 103.80 22.90 25 9105 248 2348707
Foot deformity 102.68 22.90 39 9091 1950 2347005
Renal disorder 101.40 22.90 49 9081 4439 2344516
Confusional state 99.44 22.90 91 9039 24253 2324702
Melaena 99.37 22.90 47 9083 4059 2344896
Erythema multiforme 99.29 22.90 39 9091 2136 2346819
Palpitations 99.19 22.90 77 9053 16379 2332576
Impaired work ability 98.91 22.90 37 9093 1773 2347182
Inflammation 97.33 22.90 53 9077 6160 2342795
Contusion 95.24 22.90 68 9062 12742 2336213
Upper limb fracture 94.13 22.90 40 9090 2683 2346272
Back disorder 91.72 22.90 34 9096 1588 2347367
Haemorrhage 89.97 22.90 62 9068 10977 2337978
Fine motor skill dysfunction 89.96 22.90 23 9107 297 2348658
Migraine 89.59 22.90 61 9069 10592 2338363
Cyst 88.64 22.90 33 9097 1560 2347395
Haemoglobin decreased 88.41 22.90 75 9055 18076 2330879
Hypotension 87.81 22.90 97 9033 32339 2316616
Musculoskeletal pain 86.32 22.90 60 9070 10770 2338185
Pulmonary fibrosis 85.39 22.90 37 9093 2603 2346352
Alanine aminotransferase increased 85.29 22.90 66 9064 13966 2334989
Bloody discharge 85.14 22.90 19 9111 130 2348825
Completed suicide 84.65 22.90 78 9052 20956 2327999
Fracture 84.18 22.90 37 9093 2694 2346261
Aspartate aminotransferase increased 82.55 22.90 62 9068 12550 2336405
Skin lesion 82.13 22.90 41 9089 3984 2344971
Exostosis 82.03 22.90 30 9100 1348 2347607
Disease recurrence 81.97 22.90 39 9091 3412 2345543
Anxiety 81.53 22.90 89 9041 29270 2319685
Ankylosing spondylitis 80.56 22.90 25 9105 673 2348282
Ulcer 79.84 22.90 32 9098 1848 2347107
Neck pain 79.17 22.90 50 9080 7647 2341308
Cataract 77.86 22.90 45 9085 5863 2343092
Off label use 77.74 22.90 140 8990 73458 2275497
Thyroid neoplasm 77.55 22.90 24 9106 640 2348315
Toxic skin eruption 77.45 22.90 33 9097 2227 2346728
Bone erosion 76.97 22.90 23 9107 543 2348412
Movement disorder 76.59 22.90 35 9095 2793 2346162
Bone cyst 76.50 22.90 18 9112 160 2348795
Drug-induced liver injury 76.42 22.90 38 9092 3661 2345294
Hypermobility syndrome 75.82 22.90 14 9116 29 2348926
Rectal haemorrhage 75.57 22.90 44 9086 5812 2343143
C-reactive protein increased 75.48 22.90 45 9085 6210 2342745
Constipation 75.23 22.90 74 9056 21555 2327400
Lyme disease 74.78 22.90 21 9109 395 2348560
Transient ischaemic attack 74.73 22.90 44 9086 5934 2343021
Gastric haemorrhage 73.81 22.90 26 9104 1047 2347908
Upper gastrointestinal haemorrhage 73.45 22.90 31 9099 2043 2346912
Product use issue 71.26 22.90 56 9074 12113 2336842
Face oedema 71.19 22.90 37 9093 3911 2345044
Asthma 70.46 22.90 54 9076 11260 2337695
Hyperkalaemia 70.07 22.90 42 9088 5851 2343104
Joint range of motion decreased 69.95 22.90 29 9101 1827 2347128
Osteosclerosis 69.18 22.90 19 9111 328 2348627
Dehydration 67.90 22.90 71 9059 22224 2326731
Rotator cuff syndrome 67.05 22.90 28 9102 1797 2347158
Rash erythematous 66.96 22.90 41 9089 5935 2343020
Somnolence 66.58 22.90 72 9058 23413 2325542
Diverticulitis 66.53 22.90 36 9094 4129 2344826
Respiratory tract congestion 66.24 22.90 30 9100 2344 2346611
Dermatitis 66.17 22.90 30 9100 2350 2346605
Cardiac arrest 65.22 22.90 58 9072 14872 2334083
C-reactive protein abnormal 65.20 22.90 22 9108 777 2348178
Cerebral infarction 64.39 22.90 36 9094 4401 2344554
Red blood cell sedimentation rate increased 62.79 22.90 28 9102 2109 2346846
Coronary artery occlusion 62.53 22.90 24 9106 1234 2347721
Angina pectoris 62.40 22.90 34 9096 3953 2345002
Burning sensation 61.50 22.90 43 9087 7785 2341170
Neuralgia 61.29 22.90 30 9100 2792 2346163
Crohn's disease 60.47 22.90 40 9090 6615 2342340
Chest discomfort 60.40 22.90 55 9075 14540 2334415
Intervertebral disc degeneration 60.16 22.90 25 9105 1584 2347371
Shock 59.51 22.90 33 9097 3971 2344984
Intervertebral disc protrusion 59.17 22.90 30 9100 3011 2345944
Dysphagia 58.43 22.90 51 9079 12754 2336201
Bone swelling 58.01 22.90 15 9115 203 2348752
Tremor 57.96 22.90 63 9067 20598 2328357
Therapeutic response decreased 57.64 22.90 40 9090 7155 2341800
Bunion operation 57.23 22.90 14 9116 149 2348806
Neoplasm malignant 57.21 22.90 35 9095 5058 2343897
Glaucoma 56.95 22.90 26 9104 2069 2346886
Synovitis 56.29 22.90 28 9102 2698 2346257
Purpura senile 56.21 22.90 10 9120 15 2348940
Haematochezia 55.95 22.90 35 9095 5260 2343695
Coma 55.89 22.90 43 9087 9013 2339942
Diverticulum 55.37 22.90 23 9107 1456 2347499
Blister 55.08 22.90 38 9092 6733 2342222
Hepatic enzyme increased 55.00 22.90 44 9086 9758 2339197
Myalgia 55.00 22.90 65 9065 23268 2325687
Toxicity to various agents 54.83 22.90 77 9053 32677 2316278
Vertigo 54.53 22.90 43 9087 9341 2339614
Dysstasia 54.30 22.90 28 9102 2911 2346044
Urinary retention 53.88 22.90 30 9100 3637 2345318
Photosensitivity reaction 53.31 22.90 26 9104 2401 2346554
Herpes zoster 53.18 22.90 43 9087 9682 2339273
White blood cell count abnormal 51.76 22.90 18 9112 697 2348258
Discomfort 51.76 22.90 33 9097 5126 2343829
Diabetes mellitus 51.60 22.90 38 9092 7457 2341498
Urinary tract infection 51.02 22.90 71 9059 29871 2319084
Purpura 50.90 22.90 23 9107 1787 2347168
Cardiac failure 50.87 22.90 46 9084 12048 2336907
Blood pressure decreased 50.84 22.90 41 9089 9195 2339760
Rheumatoid nodule 50.36 22.90 17 9113 601 2348354
Tachycardia 49.48 22.90 52 9078 16357 2332598
Road traffic accident 49.39 22.90 30 9100 4278 2344677
Chronic obstructive pulmonary disease 48.99 22.90 36 9094 7041 2341914
Knee arthroplasty 48.63 22.90 26 9104 2909 2346046
Abdominal distension 48.57 22.90 42 9088 10369 2338586
Product prescribing error 48.43 22.90 26 9104 2934 2346021
Product use in unapproved indication 47.89 22.90 43 9087 11157 2337798
Lower respiratory tract infection 47.82 22.90 32 9098 5392 2343563
Embolism 47.74 22.90 20 9110 1293 2347662
Liver disorder 47.52 22.90 34 9096 6380 2342575
Heart rate irregular 47.38 22.90 24 9106 2403 2346552
Rash maculo-papular 47.19 22.90 29 9101 4223 2344732
Agranulocytosis 47.14 22.90 27 9103 3455 2345500
Cardiac failure congestive 46.73 22.90 50 9080 16051 2332904
Cystitis 46.68 22.90 32 9098 5610 2343345
Musculoskeletal disorder 46.46 22.90 24 9106 2504 2346451
Eye disorder 46.38 22.90 26 9104 3193 2345762
Memory impairment 46.37 22.90 45 9085 12878 2336077
Candida infection 46.34 22.90 25 9105 2848 2346107
Muscular weakness 46.33 22.90 48 9082 14849 2334106
Kounis syndrome 46.07 22.90 13 9117 249 2348706
Procedural haemorrhage 45.77 22.90 15 9115 483 2348472
Angioedema 45.64 22.90 37 9093 8359 2340596
Red blood cell sedimentation rate abnormal 45.05 22.90 15 9115 508 2348447
Treatment noncompliance 44.87 22.90 31 9099 5503 2343452
Hiatus hernia 44.79 22.90 22 9108 2062 2346893
Tarsal tunnel syndrome 44.77 22.90 9 9121 34 2348921
Pancreatitis 44.76 22.90 36 9094 8043 2340912
Mouth ulceration 44.23 22.90 27 9103 3885 2345070
Colitis 44.09 22.90 30 9100 5196 2343759
Dry mouth 44.08 22.90 36 9094 8217 2340738
Hepatic steatosis 43.73 22.90 25 9105 3188 2345767
Duodenal ulcer 43.70 22.90 18 9112 1115 2347840
Impaired healing 43.14 22.90 30 9100 5381 2343574
Spinal stenosis 43.01 22.90 19 9111 1399 2347556
Pulmonary congestion 43.00 22.90 21 9109 1944 2347011
Cardio-respiratory arrest 42.87 22.90 37 9093 9109 2339846
Blood alkaline phosphatase increased 42.41 22.90 32 9098 6513 2342442
Faeces discoloured 42.21 22.90 22 9108 2337 2346618
Dermatitis allergic 42.15 22.90 21 9109 2030 2346925
Coronary artery stenosis 42.01 22.90 16 9114 805 2348150
Metabolic surgery 41.93 22.90 11 9119 158 2348797
Hepatitis 41.10 22.90 31 9099 6306 2342649
Post procedural haemorrhage 40.93 22.90 18 9112 1311 2347644
Groin pain 40.66 22.90 18 9112 1332 2347623
Speech disorder 40.55 22.90 31 9099 6433 2342522
Rash pruritic 40.52 22.90 33 9097 7502 2341453
Platelet count decreased 40.51 22.90 46 9084 15767 2333188
Scar 40.50 22.90 20 9110 1897 2347058
Peritonitis 40.41 22.90 22 9108 2552 2346403
Ventricular extrasystoles 40.02 22.90 20 9110 1946 2347009
Substance-induced psychotic disorder 39.58 22.90 12 9118 298 2348657
International normalised ratio increased 39.18 22.90 32 9098 7304 2341651
Spinal osteoarthritis 39.12 22.90 19 9111 1738 2347217
Dysarthria 39.04 22.90 30 9100 6272 2342683
Deep vein thrombosis 39.01 22.90 41 9089 12891 2336064
Throat tightness 38.69 22.90 26 9104 4410 2344545
Joint stiffness 38.54 22.90 25 9105 3998 2344957
Gallbladder disorder 38.43 22.90 22 9108 2812 2346143
Product substitution issue 37.85 22.90 27 9103 5042 2343913
Emphysema 37.69 22.90 16 9114 1069 2347886
Hand deformity 37.68 22.90 16 9114 1070 2347885
Frequent bowel movements 37.20 22.90 19 9111 1935 2347020
Alopecia 37.20 22.90 52 9078 21949 2327006
Influenza 37.12 22.90 40 9090 12938 2336017
Oral candidiasis 37.10 22.90 19 9111 1946 2347009
Hypoacusis 37.09 22.90 23 9107 3402 2345553
Liver function test abnormal 36.53 22.90 31 9099 7459 2341496
Hyperhidrosis 36.38 22.90 43 9087 15379 2333576
Toxic epidermal necrolysis 36.31 22.90 22 9108 3122 2345833
Generalised oedema 36.24 22.90 20 9110 2383 2346572
Blood urea increased 36.01 22.90 23 9107 3582 2345373
Adverse drug reaction 35.80 22.90 32 9098 8251 2340704
Ulcer haemorrhage 35.79 22.90 13 9117 572 2348383
Stomatitis 35.18 22.90 34 9096 9676 2339279
Disturbance in attention 35.08 22.90 27 9103 5658 2343297
Thrombocytopenia 35.03 22.90 47 9083 19084 2329871
Haemorrhage subcutaneous 34.58 22.90 13 9117 631 2348324
Lactic acidosis 34.40 22.90 26 9104 5304 2343651
Colitis ischaemic 34.34 22.90 17 9113 1620 2347335
Vasculitis 34.15 22.90 19 9111 2299 2346656
Malignant polyp 34.14 22.90 6 9124 8 2348947
Cardiovascular disorder 33.87 22.90 19 9111 2336 2346619
Jaundice 33.64 22.90 26 9104 5482 2343473
Hepatitis cholestatic 33.48 22.90 15 9115 1142 2347813
Eczema 33.39 22.90 21 9109 3184 2345771
Thrombosis 33.09 22.90 32 9098 9112 2339843
Gastrointestinal ulcer haemorrhage 33.06 22.90 9 9121 150 2348805
Decreased appetite 33.03 22.90 57 9073 28834 2320121
Lung disorder 32.97 22.90 27 9103 6185 2342770
Cholestasis 32.91 22.90 22 9108 3699 2345256
Back injury 32.90 22.90 14 9116 941 2348014
Musculoskeletal discomfort 32.80 22.90 18 9112 2120 2346835
Limb injury 32.74 22.90 19 9111 2491 2346464
Delirium 32.65 22.90 25 9105 5198 2343757
Hallucination 32.32 22.90 30 9100 8118 2340837
Bursitis 31.88 22.90 17 9113 1891 2347064
Gastroenteritis 31.75 22.90 20 9110 3040 2345915
Vision blurred 31.50 22.90 39 9091 14629 2334326
Visual impairment 31.48 22.90 35 9095 11720 2337235
Heart rate increased 31.36 22.90 34 9096 11071 2337884
Hepatic function abnormal 31.33 22.90 26 9104 6066 2342889
Disease progression 31.30 22.90 42 9088 17053 2331902
Blood pressure systolic increased 31.29 22.90 18 9112 2321 2346634
Gastric perforation 31.25 22.90 10 9120 298 2348657
Antinuclear antibody positive 31.22 22.90 14 9116 1068 2347887
Skin ulcer 31.18 22.90 22 9108 4037 2344918
Acute myocardial infarction 31.17 22.90 24 9106 5031 2343924
Meniscus injury 31.02 22.90 14 9116 1084 2347871
Respiratory arrest 31.01 22.90 26 9104 6152 2342803
Heart rate decreased 30.76 22.90 21 9109 3655 2345300
Spinal fracture 30.70 22.90 19 9111 2800 2346155
Neuropathy peripheral 30.54 22.90 34 9096 11398 2337557
Therapy non-responder 30.53 22.90 29 9101 8075 2340880
Joint destruction 30.36 22.90 10 9120 327 2348628
Syncope 30.20 22.90 41 9089 16834 2332121
Haematocrit decreased 29.96 22.90 22 9108 4296 2344659
Post procedural complication 29.88 22.90 19 9111 2935 2346020
Vestibular disorder 29.78 22.90 9 9121 221 2348734
Type 2 diabetes mellitus 29.66 22.90 17 9113 2177 2346778
Balance disorder 29.56 22.90 31 9099 9716 2339239
Loss of employment 29.46 22.90 8 9122 132 2348823
Nerve compression 29.37 22.90 13 9117 961 2347994
Resorption bone increased 29.33 22.90 9 9121 233 2348722
Hip arthroplasty 29.21 22.90 16 9114 1878 2347077
Ankle fracture 29.16 22.90 17 9113 2248 2346707
Hyperlipidaemia 29.06 22.90 18 9112 2656 2346299
Economic problem 28.88 22.90 10 9120 382 2348573
Liver injury 28.82 22.90 17 9113 2297 2346658
Ulcerative keratitis 28.74 22.90 11 9119 561 2348394
Tinnitus 28.69 22.90 23 9107 5112 2343843
Chronic kidney disease 28.61 22.90 21 9109 4097 2344858
Chromaturia 28.58 22.90 18 9112 2735 2346220
Duodenal ulcer haemorrhage 28.35 22.90 10 9120 404 2348551
Hysterectomy 28.33 22.90 15 9115 1645 2347310
Pleural effusion 28.29 22.90 33 9097 11635 2337320
Cholelithiasis 28.26 22.90 24 9106 5779 2343176
Joint injury 28.09 22.90 17 9113 2407 2346548
Iron deficiency 28.07 22.90 11 9119 598 2348357
Pruritus allergic 28.07 22.90 8 9122 159 2348796
Sinusitis 27.84 22.90 39 9091 16487 2332468
Wrist fracture 27.81 22.90 15 9115 1708 2347247
Coronary artery disease 27.77 22.90 24 9106 5915 2343040
Disseminated intravascular coagulation 27.70 22.90 19 9111 3331 2345624
Infusion related reaction 27.67 22.90 30 9100 9766 2339189
Seizure 27.60 22.90 48 9082 24418 2324537
Limb discomfort 27.56 22.90 19 9111 3360 2345595
Erosive oesophagitis 27.51 22.90 9 9121 288 2348667
Livedo reticularis 27.43 22.90 10 9120 445 2348510
Drug ineffective for unapproved indication 27.35 22.90 18 9112 2948 2346007
Influenza like illness 27.29 22.90 33 9097 12081 2336874
Kidney infection 27.18 22.90 17 9113 2552 2346403
Rib fracture 27.08 22.90 17 9113 2568 2346387
Hepatotoxicity 27.05 22.90 19 9111 3462 2345493
Miliaria 26.68 22.90 8 9122 191 2348764
Hepatocellular injury 26.65 22.90 20 9110 4035 2344920
Bone marrow failure 26.64 22.90 23 9107 5663 2343292
Haematoma 26.63 22.90 22 9108 5099 2343856
Transaminases increased 26.60 22.90 21 9109 4566 2344389
Dementia 26.51 22.90 17 9113 2664 2346291
Overdose 26.40 22.90 42 9088 19865 2329090
Gastrointestinal ulcer 26.14 22.90 9 9121 338 2348617
Scoliosis 26.08 22.90 12 9118 972 2347983
Sepsis 25.90 22.90 40 9090 18448 2330507
Urinary incontinence 25.89 22.90 20 9110 4213 2344742
Cardiac murmur 25.61 22.90 14 9116 1637 2347318
Diverticulum intestinal haemorrhagic 25.57 22.90 8 9122 221 2348734
Carpal tunnel syndrome 25.54 22.90 15 9115 2010 2346945
Amnesia 25.52 22.90 25 9105 7228 2341727
Pancytopenia 25.48 22.90 31 9099 11421 2337534
Vertigo positional 25.41 22.90 9 9121 368 2348587
Vitreous detachment 25.25 22.90 9 9121 375 2348580
Vitamin D decreased 25.21 22.90 12 9118 1049 2347906
Pulmonary oedema 25.21 22.90 25 9105 7338 2341617
Erythema nodosum 25.17 22.90 11 9119 789 2348166
Chills 25.16 22.90 36 9094 15516 2333439
Surgery 25.14 22.90 22 9108 5513 2343442
Iron deficiency anaemia 25.04 22.90 15 9115 2084 2346871
Inflammatory bowel disease 25.01 22.90 10 9120 573 2348382
Product dispensing error 24.85 22.90 16 9114 2525 2346430
Lung neoplasm malignant 24.56 22.90 17 9113 3025 2345930
Pain in jaw 24.38 22.90 23 9107 6349 2342606
Irritable bowel syndrome 24.18 22.90 14 9116 1827 2347128
Blood triglycerides increased 24.13 22.90 15 9115 2228 2346727
Dermatitis bullous 24.01 22.90 13 9117 1491 2347464
Urine output decreased 23.89 22.90 13 9117 1506 2347449
Cyanosis 23.85 22.90 17 9113 3168 2345787
Pulmonary embolism 23.77 22.90 38 9092 18045 2330910
Adrenal suppression 23.68 22.90 7 9123 159 2348796
Enthesopathy 23.64 22.90 7 9123 160 2348795
Colitis microscopic 23.51 22.90 11 9119 925 2348030
Colitis ulcerative 23.43 22.90 16 9114 2786 2346169
Haematuria 23.40 22.90 19 9111 4299 2344656
Poor quality sleep 23.32 22.90 14 9116 1953 2347002
Encephalitis brain stem 23.26 22.90 5 9125 28 2348927
Medication error 23.21 22.90 22 9108 6109 2342846
No adverse event 23.18 22.90 27 9103 9501 2339454
Pancreatitis acute 23.12 22.90 18 9112 3835 2345120
Flushing 23.01 22.90 30 9100 11841 2337114
Tubulointerstitial nephritis 22.98 22.90 15 9115 2423 2346532

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1339.96 22.81 407 3652 14728 1727994
Drug ineffective 409.60 22.81 272 3787 63529 1679193
Myocardial infarction 317.38 22.81 171 3888 27003 1715719
Gastrointestinal haemorrhage 302.36 22.81 135 3924 14132 1728590
Rash 253.94 22.81 168 3891 38525 1704197
Pain 204.75 22.81 128 3931 26529 1716193
Pruritus 164.38 22.81 106 3953 23116 1719606
Chest pain 163.79 22.81 100 3959 19814 1722908
Rheumatoid arthritis 163.28 22.81 63 3996 4522 1738200
Acute kidney injury 159.83 22.81 122 3937 34822 1707900
Ankylosing spondylitis 149.90 22.81 39 4020 754 1741968
Cerebrovascular accident 142.45 22.81 88 3971 17778 1724944
Arthralgia 139.27 22.81 96 3963 23348 1719374
Asthenia 134.67 22.81 110 3949 34560 1708162
Condition aggravated 114.80 22.81 82 3977 21068 1721654
Dyspnoea 112.34 22.81 119 3940 51940 1690782
Loss of personal independence in daily activities 111.10 22.81 40 4019 2359 1740363
Nausea 110.41 22.81 117 3942 51079 1691643
Atrial fibrillation 106.76 22.81 69 3990 15042 1727680
Dizziness 102.82 22.81 94 3965 34267 1708455
Erythema 100.74 22.81 65 3994 14123 1728599
Abdominal discomfort 99.40 22.81 55 4004 9026 1733696
Urticaria 99.23 22.81 61 3998 12180 1730542
Hypersensitivity 97.49 22.81 57 4002 10387 1732335
Anaemia 94.81 22.81 84 3975 29373 1713349
Arthritis 94.78 22.81 41 4018 3934 1738788
Gastric ulcer 88.80 22.81 35 4024 2650 1740072
Pneumonia 88.04 22.81 99 3960 46083 1696639
Hypertension 84.44 22.81 66 3993 19382 1723340
Oedema peripheral 81.31 22.81 59 4000 15491 1727231
Melaena 81.17 22.81 40 4019 5170 1737552
Drug eruption 79.10 22.81 33 4026 2893 1739829
Pain in extremity 78.69 22.81 62 3997 18410 1724312
Osteoarthritis 76.17 22.81 30 4029 2266 1740456
Vomiting 76.14 22.81 84 3975 38231 1704491
Pyrexia 75.92 22.81 92 3967 46308 1696414
Renal failure 74.31 22.81 62 3997 19955 1722767
Drug interaction 73.00 22.81 71 3988 27887 1714835
Anaphylactic reaction 72.32 22.81 39 4020 6074 1736648
Infection 71.75 22.81 50 4009 12310 1730412
Blood pressure increased 70.73 22.81 47 4012 10706 1732016
Knee arthroplasty 68.65 22.81 22 4037 906 1741816
Abdominal pain 68.48 22.81 61 3998 21429 1721293
Therapeutic product effect incomplete 67.93 22.81 36 4023 5412 1737310
Fatigue 67.76 22.81 91 3968 50690 1692032
Renal impairment 67.27 22.81 48 4011 12266 1730456
Haemorrhage 67.16 22.81 44 4015 9785 1732937
Back pain 66.97 22.81 54 4005 16559 1726163
Haematemesis 66.37 22.81 33 4026 4344 1738378
Joint swelling 65.44 22.81 37 4022 6316 1736406
Therapeutic product effect decreased 63.05 22.81 36 4023 6261 1736461
Gastric ulcer haemorrhage 63.04 22.81 21 4038 978 1741744
Transposition of the great vessels 62.69 22.81 14 4045 136 1742586
Abdominal pain upper 62.66 22.81 44 4015 10957 1731765
Acute myocardial infarction 62.50 22.81 40 4019 8547 1734175
Fracture 61.48 22.81 21 4038 1057 1741665
Hypotension 60.55 22.81 66 3993 29588 1713134
Anaphylactic shock 59.73 22.81 27 4032 2872 1739850
Cardiac disorder 58.89 22.81 37 4022 7654 1735068
Malaise 57.24 22.81 64 3995 29501 1713221
Urinary retention 57.13 22.81 32 4027 5363 1737359
Haematochezia 57.02 22.81 31 4028 4901 1737821
Swelling face 56.95 22.81 30 4029 4453 1738269
Diarrhoea 56.36 22.81 86 3973 53766 1688956
Disease recurrence 56.23 22.81 25 4034 2557 1740165
Pulmonary embolism 55.92 22.81 44 4015 13015 1729707
Ependymoma 55.65 22.81 10 4049 26 1742696
Gait disturbance 54.92 22.81 43 4016 12627 1730095
Peptic ulcer 54.30 22.81 16 4043 495 1742227
Interstitial lung disease 53.40 22.81 38 4021 9658 1733064
Cardiac failure 52.96 22.81 42 4017 12560 1730162
Hepatic cirrhosis 52.41 22.81 24 4035 2629 1740093
Transient ischaemic attack 52.31 22.81 29 4030 4762 1737960
Face oedema 52.09 22.81 23 4036 2313 1740409
Swelling 51.92 22.81 33 4026 6963 1735759
Dyspepsia 51.24 22.81 29 4030 4956 1737766
Angina pectoris 51.06 22.81 29 4030 4989 1737733
Loss of consciousness 50.89 22.81 44 4015 14831 1727891
Syncope 50.69 22.81 43 4016 14126 1728596
Arthropathy 50.63 22.81 24 4035 2843 1739879
Hypoaesthesia 50.63 22.81 37 4022 9798 1732924
Stevens-Johnson syndrome 49.97 22.81 25 4034 3332 1739390
Impaired work ability 49.41 22.81 18 4041 1095 1741627
Disease progression 49.08 22.81 46 4013 17217 1725505
Contraindicated product administered 48.35 22.81 19 4040 1425 1741297
Renal disorder 48.11 22.81 26 4033 4060 1738662
Palpitations 47.74 22.81 31 4028 6783 1735939
Product use in unapproved indication 47.49 22.81 35 4024 9387 1733335
Weight decreased 47.02 22.81 51 4008 22702 1720020
Blood pressure fluctuation 46.53 22.81 18 4041 1294 1741428
Coronary artery disease 46.11 22.81 35 4024 9811 1732911
Musculoskeletal pain 45.46 22.81 27 4032 5047 1737675
Faeces discoloured 45.15 22.81 21 4038 2383 1740339
Erythema multiforme 44.85 22.81 19 4040 1727 1740995
Constipation 44.62 22.81 41 4018 14959 1727763
Haemoglobin decreased 43.72 22.81 43 4016 17071 1725651
Upper gastrointestinal haemorrhage 43.65 22.81 22 4037 2977 1739745
Blood creatinine increased 43.20 22.81 39 4020 13907 1728815
Coronary artery occlusion 41.81 22.81 19 4040 2044 1740678
Duodenal ulcer 41.42 22.81 18 4041 1742 1740980
Fall 41.20 22.81 52 4007 27162 1715560
Depression 40.94 22.81 41 4018 16628 1726094
Dehydration 40.76 22.81 42 4017 17616 1725106
Rectal haemorrhage 40.76 22.81 26 4033 5516 1737206
Flushing 40.18 22.81 27 4032 6252 1736470
Ventricular septal defect 39.89 22.81 14 4045 764 1741958
Gastrooesophageal reflux disease 39.74 22.81 24 4035 4623 1738099
Chest expansion decreased 39.29 22.81 7 4052 17 1742705
Headache 38.87 22.81 57 4002 34319 1708403
Arrhythmia 38.81 22.81 26 4033 5990 1736732
Feeling abnormal 38.11 22.81 33 4026 11133 1731589
Paraesthesia 37.94 22.81 32 4027 10419 1732303
Rash erythematous 37.88 22.81 22 4037 3943 1738779
Blood cholesterol increased 37.71 22.81 20 4039 3006 1739716
Hepatic function abnormal 37.27 22.81 27 4032 7047 1735675
Synovitis 36.64 22.81 13 4046 732 1741990
Diverticulitis 36.63 22.81 18 4041 2307 1740415
Osteopenia 36.43 22.81 12 4047 539 1742183
Duodenal ulcer haemorrhage 36.11 22.81 13 4046 764 1741958
Joint range of motion decreased 35.64 22.81 13 4046 793 1741929
C-reactive protein increased 34.55 22.81 24 4035 5861 1736861
Gastrointestinal disorder 34.23 22.81 22 4037 4726 1737996
Inflammatory bowel disease 34.08 22.81 11 4048 463 1742259
Toxic skin eruption 33.97 22.81 16 4043 1867 1740855
Tinnitus 33.94 22.81 19 4040 3176 1739546
Eczema 33.67 22.81 17 4042 2307 1740415
International normalised ratio increased 33.43 22.81 27 4032 8272 1734450
Confusional state 32.73 22.81 41 4018 21237 1721485
Respiratory failure 32.56 22.81 34 4025 14471 1728251
Sepsis 32.39 22.81 39 4020 19399 1723323
Blood urea increased 31.93 22.81 21 4038 4690 1738032
Benign abdominal neoplasm 31.87 22.81 5 4054 3 1742719
Thrombosis 31.43 22.81 25 4034 7496 1735226
Rash maculo-papular 31.33 22.81 19 4040 3684 1739038
Insomnia 31.03 22.81 35 4024 16241 1726481
Neutropenia 31.02 22.81 37 4022 18223 1724499
Liver disorder 30.80 22.81 22 4037 5614 1737108
Lip swelling 30.72 22.81 17 4042 2778 1739944
Coronary artery stenosis 30.26 22.81 14 4045 1568 1741154
Peripheral swelling 30.15 22.81 25 4034 7946 1734776
Cerebral infarction 30.01 22.81 21 4038 5188 1737534
Rhinitis 29.89 22.81 11 4048 688 1742034
Back disorder 29.64 22.81 12 4047 972 1741750
Jaundice 29.36 22.81 22 4037 6040 1736682
Enthesopathy 29.19 22.81 7 4052 95 1742627
Blood pressure decreased 28.96 22.81 24 4035 7622 1735100
Asthma 28.79 22.81 20 4039 4884 1737838
Drug-induced liver injury 28.40 22.81 17 4042 3220 1739502
Drug ineffective for unapproved indication 28.33 22.81 14 4045 1815 1740907
Acute generalised exanthematous pustulosis 28.12 22.81 12 4047 1110 1741612
Malignant neoplasm progression 27.93 22.81 31 4028 14127 1728595
Intentional product misuse 27.67 22.81 23 4036 7335 1735387
Axial spondyloarthritis 27.30 22.81 5 4054 15 1742707
Sudden death 27.25 22.81 16 4043 2924 1739798
Metabolic acidosis 27.05 22.81 20 4039 5382 1737340
Intermittent claudication 26.99 22.81 9 4050 420 1742302
Neuropathy peripheral 26.92 22.81 25 4034 9228 1733494
Hernia 26.85 22.81 12 4047 1240 1741482
Diabetes mellitus 26.82 22.81 22 4037 6886 1735836
Visual impairment 26.69 22.81 21 4038 6197 1736525
Decreased activity 26.44 22.81 10 4049 675 1742047
Gastritis 26.39 22.81 16 4043 3101 1739621
Sacroiliitis 25.94 22.81 7 4052 156 1742566
Lung disorder 25.74 22.81 19 4040 5100 1737622
Duodenal ulcer perforation 25.62 22.81 8 4051 302 1742420
Respiratory distress 25.61 22.81 19 4040 5138 1737584
Crohn's disease 25.28 22.81 18 4041 4569 1738153
Arachnoiditis 24.85 22.81 6 4053 84 1742638
Mitral valve incompetence 24.66 22.81 13 4046 1929 1740793
Anxiety 23.99 22.81 30 4029 15497 1727225
Somnolence 23.74 22.81 31 4028 16708 1726014
Deep vein thrombosis 23.60 22.81 24 4035 9896 1732826
Cardiac arrest 23.37 22.81 30 4029 15900 1726822
Cough 23.36 22.81 33 4026 19164 1723558
Influenza 23.07 22.81 20 4039 6747 1735975
Drug intolerance 22.89 22.81 19 4040 6043 1736679

Pharmacologic Action:

SourceCodeDescription
ATC C08CA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC L01XX33 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Other antineoplastic agents
ATC M01AH01 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D052246 Cyclooxygenase 2 Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35481 non-narcotic analgesic
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
FDA Chemical/Ingredient N0000175721 Nonsteroidal Anti-inflammatory Compounds

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatoid arthritis indication 69896004 DOID:7148
Dysmenorrhea indication 266599000
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001
Acute postoperative pain indication 107401000119105
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Gastrointestinal hemorrhage contraindication 74474003
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.79 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
200MG CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
200MG CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.24 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 5.48 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.14 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 6.16 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 4.92 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 4.86 DRUG MATRIX
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Enzyme IC50 5.03 DRUG MATRIX
Carbonic anhydrase 2 Enzyme IC50 7.68 WOMBAT-PK
Sodium-dependent dopamine transporter Transporter Ki 6.18 WOMBAT-PK
Carbonic anhydrase 12 Enzyme Ki 7.74 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.06 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 7.01 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 7.30 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.13 CHEMBL
3-phosphoinositide-dependent protein kinase 1 Kinase IC50 4.32 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.10 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 6.16 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 5.66 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.80 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 4.30 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 7.03 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 7.03 CHEMBL
Mitogen-activated protein kinase 14 Kinase IC50 6.09 CHEMBL
D(1A) dopamine receptor GPCR Ki 4.85 DRUG MATRIX
Progesterone receptor Transcription factor Ki 5.63 DRUG MATRIX
Cytochrome c oxidase subunit 2 Enzyme IC50 7.22 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 8.43 CHEMBL
Carbonic anhydrase Enzyme Ki 4.41 CHEMBL
Alpha carbonic anhydrase Unclassified Ki 7.47 CHEMBL
Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase Enzyme Ki 5.11 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.40 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.24 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 9.29 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 9.15 CHEMBL
Astrosclerin-3 Unclassified Ki 6.14 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.96 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 4.99 CHEMBL
Carbonic anhydrase Unclassified Ki 6.16 CHEMBL
Delta carbonic anhydrase Unclassified Ki 6.58 CHEMBL
Carbonic anhydrase Enzyme Ki 6.97 CHEMBL
Cyclooxygenase 2; Prostaglandin G/H synthase-2; Uncharacterized protein Enzyme IC50 6.05 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.25 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.85 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 7.35 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.11 CHEMBL
Cytochrome c oxidase subunit 1 Unclassified IC50 4.61 CHEMBL
Carbonic anhydrase Enzyme Ki 7.68 CHEMBL
Carbonic anhydrase Enzyme Ki 6.85 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 6.15 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.54 CHEMBL
Carbonic anhydrase Unclassified Ki 6.76 CHEMBL
Carbonic anhydrase Enzyme Ki 6.94 CHEMBL

External reference:

IDSource
D000068579 MESH_DESCRIPTOR_UI
4021143 VUID
N0000148596 NUI
C0538927 UMLSCUI
D00567 KEGG_DRUG
370187009 SNOMEDCT_US
4021143 VANDF
007731 NDDF
174627 MMSL
d04380 MMSL
7872 MMSL
140587 RXNORM
116081000 SNOMEDCT_US
CHEMBL118 ChEMBL_ID
DB00482 DRUGBANK_ID
JCX84Q7J1L UNII
7767 INN_ID
CEL PDB_CHEM_ID
CHEBI:41423 CHEBI
2892 IUPHAR_LIGAND_ID
2662 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1515 CAPSULE 50 mg ORAL NDA 20 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1520 CAPSULE 100 mg ORAL NDA 20 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1525 CAPSULE 200 mg ORAL NDA 20 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1530 CAPSULE 400 mg ORAL NDA 20 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7165 CAPSULE 100 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7166 CAPSULE 200 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7170 CAPSULE 400 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7306 CAPSULE 50 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7150 CAPSULE 200 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7160 CAPSULE 100 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7165 CAPSULE 50 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7170 CAPSULE 400 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3982 CAPSULE 50 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3983 CAPSULE 100 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3984 CAPSULE 200 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3985 CAPSULE 400 mg ORAL ANDA 19 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0615-8297 CAPSULE 200 mg ORAL ANDA 19 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0615-8338 CAPSULE 200 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0904-6502 CAPSULE 100 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0904-6503 CAPSULE 200 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-917 CAPSULE 200 mg ORAL NDA authorized generic 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-918 CAPSULE 200 mg ORAL NDA authorized generic 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-929 CAPSULE 200 mg ORAL NDA authorized generic 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-953 CAPSULE 200 mg ORAL ANDA 19 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-967 CAPSULE 200 mg ORAL NDA authorized generic 19 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-307 CAPSULE 50 mg ORAL ANDA 19 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-310 CAPSULE 400 mg ORAL ANDA 19 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-441 CAPSULE 100 mg ORAL ANDA 19 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-442 CAPSULE 200 mg ORAL ANDA 19 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 16590-045 CAPSULE 100 mg ORAL NDA 19 sections