celecoxib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 568 169590-42-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • celecoxib
  • celebrex
  • celecox
  • celocoxib
  • onsenal
A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN.
  • Molecular weight: 381.37
  • Formula: C17H14F3N3O2S
  • CLOGP: 4.37
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 77.98
  • ALOGS: -4.88
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 17.49 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1998 FDA GD SEARLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1528.67 9.70 2699 140320 241126 46301917
Rheumatoid arthritis 651.52 9.70 1909 141110 238306 46304737
Drug ineffective 570.60 9.70 3779 139240 674059 45868984
Arthralgia 402.16 9.70 2185 140834 362418 46180625
Death 291.78 9.70 360 142659 335188 46207855
Therapeutic product effect decreased 227.32 9.70 661 142358 81940 46461103
Toxicity to various agents 220.06 9.70 195 142824 211571 46331472
Musculoskeletal stiffness 219.53 9.70 730 142289 97263 46445780
Loss of personal independence in daily activities 219.20 9.70 518 142501 56665 46486378
Completed suicide 202.24 9.70 97 142922 145823 46397220
Pain 182.54 9.70 2245 140774 474703 46068340
Maternal exposure during pregnancy 181.96 9.70 45 142974 102504 46440539
Osteoarthritis 161.68 9.70 487 142532 61538 46481505
Drug intolerance 159.72 9.70 879 142140 146170 46396873
Therapeutic product effect incomplete 156.48 9.70 561 142458 77592 46465451
Pain in extremity 152.15 9.70 1330 141689 257350 46285693
Exposure during pregnancy 148.27 9.70 73 142946 108139 46434904
Neutropenia 141.41 9.70 138 142881 143066 46399977
Drug abuse 133.54 9.70 18 143001 63390 46479653
Febrile neutropenia 129.38 9.70 64 142955 94563 46448480
Condition aggravated 129.34 9.70 1231 141788 243821 46299222
Arthropathy 128.28 9.70 557 142462 84143 46458900
Joint swelling 123.26 9.70 901 142118 165172 46377871
Contraindicated product administered 112.95 9.70 515 142504 79432 46463611
Bedridden 111.53 9.70 139 142880 9020 46534023
Arthritis 111.43 9.70 501 142518 76815 46466228
Gait inability 110.84 9.70 296 142723 34907 46508136
Pharyngitis 108.52 9.70 194 142825 17389 46525654
Ankylosing spondylitis 108.41 9.70 118 142901 6619 46536424
Toothache 101.04 9.70 182 142837 16410 46526633
Intentional overdose 98.13 9.70 38 142981 64906 46478137
Fibromyalgia 91.89 9.70 283 142736 36180 46506863
Thrombocytopenia 91.75 9.70 154 142865 126427 46416616
Gait disturbance 90.53 9.70 757 142262 144506 46398537
Foot deformity 88.62 9.70 165 142854 15260 46527783
Pemphigus 88.19 9.70 16 143003 45258 46497785
Hyponatraemia 84.38 9.70 112 142907 101220 46441823
Pleural fibrosis 84.25 9.70 77 142942 3492 46539551
Immobile 83.57 9.70 86 142933 4520 46538523
Acute kidney injury 83.44 9.70 405 142614 235450 46307593
Presbyacusis 82.98 9.70 69 142950 2753 46540290
International normalised ratio fluctuation 82.51 9.70 62 142957 2131 46540912
C-reactive protein abnormal 80.70 9.70 192 142827 21078 46521965
Hypotension 77.93 9.70 407 142612 232182 46310861
Osteoporosis 76.58 9.70 286 142733 40322 46502721
Thyroid neoplasm 74.84 9.70 73 142946 3596 46539447
Hypoaesthesia 73.25 9.70 618 142401 118251 46424792
Blood magnesium increased 72.81 9.70 66 142953 2961 46540082
White blood cell count abnormal 72.50 9.70 84 142935 5048 46537995
Overdose 72.12 9.70 126 142893 101853 46441190
Pleural thickening 71.26 9.70 61 142958 2534 46540509
Myocardial infarction 71.04 9.70 527 142492 97001 46446042
Electrocardiogram QT prolonged 69.70 9.70 35 142984 51290 46491753
Red blood cell sedimentation rate increased 69.57 9.70 190 142829 22699 46520344
Foot fracture 68.16 9.70 171 142848 19411 46523632
Bone swelling 67.98 9.70 44 142975 1184 46541859
Lower limb fracture 65.52 9.70 128 142891 12270 46530773
Dyspnoea 64.20 9.70 1153 141866 514395 46028648
Deafness neurosensory 62.56 9.70 73 142946 4421 46538622
Psoriatic arthropathy 61.89 9.70 248 142771 36131 46506912
Neoplasm malignant 61.65 9.70 185 142834 23314 46519729
Mobility decreased 58.97 9.70 352 142667 60242 46482801
Interstitial lung disease 57.46 9.70 321 142698 53628 46489415
Anaemia 56.55 9.70 506 142513 255273 46287770
Epigastric discomfort 56.39 9.70 78 142941 5606 46537437
Hypermobility syndrome 54.83 9.70 31 142988 648 46542395
Deformity 53.95 9.70 87 142932 7170 46535873
Pulmonary toxicity 53.61 9.70 69 142950 4624 46538419
Hypokalaemia 53.39 9.70 119 142900 87905 46455138
Suicide attempt 53.16 9.70 54 142965 54982 46488061
Confusional state 52.27 9.70 282 142737 159610 46383433
Seizure 52.24 9.70 197 142822 122857 46420186
Abortion spontaneous 50.50 9.70 36 142983 43610 46499433
Dry eye 50.21 9.70 205 142814 30117 46512926
Cardio-respiratory arrest 50.00 9.70 66 142953 59803 46483240
Plasma cell myeloma 49.77 9.70 38 142981 44440 46498603
Osteopenia 49.77 9.70 139 142880 16822 46526221
Drug eruption 49.56 9.70 161 142858 21168 46521875
Nerve injury 48.81 9.70 86 142933 7619 46535424
Burning mouth syndrome 48.17 9.70 24 142995 384 46542659
Hypoglycaemia 47.37 9.70 58 142961 54291 46488752
Bone cyst 45.99 9.70 43 142976 2008 46541035
Premature delivery 44.75 9.70 7 143012 22062 46520981
Intervertebral disc protrusion 44.71 9.70 151 142868 20254 46522789
Dehydration 44.43 9.70 296 142723 159244 46383799
Sepsis 44.38 9.70 240 142779 135774 46407269
Joint stiffness 43.88 9.70 182 142837 26926 46516117
Syncope 43.69 9.70 169 142850 104634 46438409
Glossodynia 43.47 9.70 43 142976 44330 46498713
Gastric disorder 43.00 9.70 179 142840 26526 46516517
Rheumatoid nodule 42.75 9.70 89 142930 8931 46534112
Disease progression 42.18 9.70 141 142878 91159 46451884
Intentional self-injury 42.07 9.70 11 143008 24155 46518888
Epicondylitis 41.94 9.70 38 142981 1704 46541339
Sopor 40.86 9.70 6 143013 19822 46523221
Osteosclerosis 40.65 9.70 52 142967 3464 46539579
Musculoskeletal pain 40.24 9.70 359 142660 69769 46473274
Nephrolithiasis 40.20 9.70 204 142815 32847 46510196
Red blood cell sedimentation rate abnormal 40.18 9.70 112 142907 13537 46529506
Fine motor skill dysfunction 40.09 9.70 53 142966 3647 46539396
Bloody discharge 39.49 9.70 29 142990 962 46542081
Pulmonary arterial hypertension 39.44 9.70 15 143004 25913 46517130
Exostosis 39.31 9.70 93 142926 10170 46532873
Vomiting 38.95 9.70 1073 141946 451721 46091322
Cyst 38.33 9.70 102 142917 11998 46531045
Pyrexia 38.12 9.70 797 142222 348005 46195038
Rotator cuff syndrome 38.08 9.70 99 142920 11484 46531559
Multiple sclerosis relapse 37.73 9.70 44 142975 42081 46500962
Disability 37.73 9.70 91 142928 10076 46532967
Nasopharyngitis 37.65 9.70 672 142347 153326 46389717
Cardiac arrest 37.53 9.70 146 142873 90253 46452790
Impaired work ability 37.51 9.70 104 142915 12532 46530511
Ulcer 37.49 9.70 128 142891 17264 46525779
Spinal stenosis 37.00 9.70 103 142916 12440 46530603
Metabolic acidosis 36.38 9.70 39 142980 38741 46504302
Premature baby 36.15 9.70 6 143013 18106 46524937
Off label use 36.12 9.70 887 142132 378954 46164089
Hospitalisation 35.78 9.70 89 142930 63296 46479747
Tachycardia 35.78 9.70 170 142849 99452 46443591
Mucosal inflammation 35.68 9.70 40 142979 38936 46504107
Intervertebral disc degeneration 35.39 9.70 105 142914 13147 46529896
Right ventricular failure 35.26 9.70 4 143015 16089 46526954
Decreased appetite 35.11 9.70 402 142617 193434 46349609
Leukopenia 34.78 9.70 101 142918 68242 46474801
Pharyngeal oedema 34.31 9.70 110 142909 14361 46528682
Infection 34.09 9.70 587 142432 133005 46410038
Anaphylactic reaction 33.67 9.70 278 142741 52834 46490209
Investigation abnormal 33.66 9.70 27 142992 1023 46542020
Fracture 33.58 9.70 119 142900 16352 46526691
Encephalopathy 33.54 9.70 32 142987 33557 46509486
Respiratory failure 33.35 9.70 163 142856 94653 46448390
Asthenia 33.33 9.70 713 142306 310362 46232681
Treatment failure 33.09 9.70 433 142586 92654 46450389
Joint injury 32.70 9.70 131 142888 19078 46523965
Pancytopenia 32.42 9.70 142 142877 84916 46458127
Bradycardia 32.28 9.70 100 142919 66198 46476845
Multiple organ dysfunction syndrome 32.09 9.70 69 142950 51641 46491402
Diarrhoea 31.31 9.70 1399 141620 558203 45984840
Antinuclear antibody positive 30.98 9.70 63 142956 6217 46536826
Product dose omission issue 30.71 9.70 349 142670 168171 46374872
Stress 30.65 9.70 266 142753 51285 46491758
Pregnancy 30.59 9.70 23 142996 27114 46515929
Product use in unapproved indication 30.15 9.70 158 142861 90115 46452928
Movement disorder 29.56 9.70 116 142903 16733 46526310
Fluid overload 29.43 9.70 24 142995 27161 46515882
Device dislocation 29.40 9.70 15 143004 21787 46521256
Systemic lupus erythematosus 29.19 9.70 102 142917 65078 46477965
Hypoxia 29.09 9.70 73 142946 51765 46491278
Lyme disease 28.99 9.70 36 142983 2327 46540716
Spinal osteoarthritis 28.64 9.70 102 142917 14049 46528994
Gastric ulcer 28.04 9.70 137 142882 21726 46521317
Acute myeloid leukaemia 27.82 9.70 7 143012 15771 46527272
Upper limb fracture 27.42 9.70 108 142911 15605 46527438
Neck pain 27.18 9.70 274 142745 55032 46488011
Fatigue 26.70 9.70 1560 141459 607137 45935906
Torsade de pointes 26.68 9.70 3 143016 12151 46530892
Somnolence 26.65 9.70 329 142690 156192 46386851
Gastric ulcer haemorrhage 26.63 9.70 51 142968 4817 46538226
Malignant neoplasm progression 26.22 9.70 106 142913 64820 46478223
Bunion operation 26.15 9.70 21 142998 797 46542246
Anti-cyclic citrullinated peptide antibody positive 26.07 9.70 13 143006 19132 46523911
Meniscus injury 25.92 9.70 57 142962 5939 46537104
Back disorder 25.92 9.70 74 142945 9067 46533976
Septic shock 25.66 9.70 91 142928 57802 46485241
Peripheral swelling 25.40 9.70 649 142370 157422 46385621
Epistaxis 25.33 9.70 106 142913 64199 46478844
Cytomegalovirus infection 25.19 9.70 12 143007 18132 46524911
Musculoskeletal disorder 24.87 9.70 104 142915 15441 46527602
Paranasal sinus inflammation 24.63 9.70 13 143006 236 46542807
Mental status changes 24.33 9.70 50 142969 38038 46505005
White blood cell count decreased 24.32 9.70 223 142796 112008 46431035
Platelet count decreased 24.25 9.70 193 142826 99831 46443212
Dermatitis allergic 23.95 9.70 89 142930 12514 46530529
Impaired healing 23.65 9.70 193 142826 36550 46506493
Cholestasis 23.12 9.70 29 142990 26864 46516179
Bursitis 23.10 9.70 121 142898 19721 46523322
C-reactive protein increased 22.72 9.70 277 142742 58313 46484730
Neuropathy peripheral 22.67 9.70 174 142845 90719 46452324
Neutropenic sepsis 22.65 9.70 5 143014 12319 46530724
Epilepsy 22.12 9.70 24 142995 23714 46519329
Premature labour 21.99 9.70 4 143015 11295 46531748
Loss of employment 21.97 9.70 23 142996 1233 46541810
Respiratory arrest 21.93 9.70 44 142975 33772 46509271
International normalised ratio increased 21.92 9.70 72 142947 46811 46496232
Enthesopathy 21.90 9.70 46 142973 4644 46538399
Clostridium difficile colitis 21.86 9.70 15 143004 18538 46524505
Malignant melanoma 21.78 9.70 75 142944 10159 46532884
Pruritus allergic 21.60 9.70 21 142998 1030 46542013
Blood potassium increased 21.53 9.70 106 142913 16861 46526182
Alopecia 21.45 9.70 359 142660 162055 46380988
Poisoning 21.44 9.70 8 143011 13986 46529057
Hepatocellular injury 21.29 9.70 36 142983 29486 46513557
Joint prosthesis user 21.27 9.70 7 143012 34 46543009
Radiculopathy 21.11 9.70 47 142972 4938 46538105
Joint range of motion decreased 21.01 9.70 97 142922 15027 46528016
Agitation 20.81 9.70 93 142926 55322 46487721
Infective pulmonary exacerbation of cystic fibrosis 20.66 9.70 4 143015 10803 46532240
Cardiac failure 20.44 9.70 152 142867 79796 46463247
Drug reaction with eosinophilia and systemic symptoms 20.43 9.70 37 142982 29511 46513532
Breast cyst excision 20.43 9.70 8 143011 69 46542974
Ascites 20.15 9.70 52 142967 36532 46506511
Hyperglycaemia 19.98 9.70 49 142970 35022 46508021
Swelling 19.93 9.70 511 142508 124000 46419043
Palmar-plantar erythrodysaesthesia syndrome 19.82 9.70 20 142999 20431 46522612
Amblyopia 19.80 9.70 11 143008 222 46542821
Joint effusion 19.78 9.70 81 142938 11914 46531129
Tuberculin test positive 19.64 9.70 34 142985 2970 46540073
Neutrophil count decreased 19.41 9.70 68 142951 43358 46499685
COVID-19 19.37 9.70 17 143002 18558 46524485
Metabolic surgery 19.22 9.70 19 143000 951 46542092
Bone erosion 19.05 9.70 68 142951 9375 46533668
Limb injury 19.03 9.70 112 142907 19062 46523981
Device issue 18.84 9.70 20 142999 19960 46523083
Lower respiratory tract infection 18.64 9.70 254 142765 54835 46488208
Diabetic ketoacidosis 18.59 9.70 17 143002 18193 46524850
Acute hepatic failure 18.58 9.70 11 143008 14710 46528333
Synovial cyst 18.48 9.70 57 142962 7289 46535754
Sedation 18.37 9.70 26 142993 22884 46520159
Gamma-glutamyltransferase increased 18.35 9.70 44 142975 31696 46511347
Tuberculosis 18.27 9.70 71 142948 10194 46532849
Body height decreased 18.20 9.70 68 142951 9584 46533459
Lactic acidosis 18.07 9.70 49 142970 33860 46509183
Injection related reaction 18.07 9.70 14 143005 504 46542539
Drug resistance 17.99 9.70 16 143003 17352 46525691
Lethargy 17.97 9.70 88 142931 51083 46491960
Oral herpes 17.81 9.70 111 142908 19279 46523764
Hyperbilirubinaemia 17.70 9.70 5 143014 10433 46532610
Transplant rejection 17.42 9.70 4 143015 9592 46533451
Gastrointestinal toxicity 17.41 9.70 40 142979 4291 46538752
Hepatic failure 17.28 9.70 49 142970 33367 46509676
Peritonitis bacterial 16.97 9.70 3 143016 8650 46534393
Constipation 16.91 9.70 405 142614 173692 46369351
Spondylitis 16.33 9.70 25 142994 1970 46541073
Bronchitis 16.10 9.70 432 142587 105547 46437496
Glomerulonephritis minimal lesion 16.10 9.70 9 143010 184 46542859
Full blood count decreased 16.09 9.70 27 142992 22184 46520859
Nodule 16.04 9.70 92 142927 15513 46527530
Clostridium difficile infection 15.99 9.70 33 142986 25070 46517973
Carpal tunnel syndrome 15.98 9.70 93 142926 15766 46527277
Malignant polyp 15.97 9.70 9 143010 187 46542856
Cardiogenic shock 15.90 9.70 16 143003 16368 46526675
Finger deformity 15.83 9.70 43 142976 5119 46537924
Tremor 15.79 9.70 254 142765 115385 46427658
Myofascial pain syndrome 15.62 9.70 24 142995 1897 46541146
Abortion induced 15.50 9.70 6 143013 10254 46532789
Blood cholesterol increased 15.43 9.70 189 142830 39824 46503219
Neoplasm progression 15.42 9.70 37 142982 26646 46516397
Pleural effusion 15.40 9.70 171 142848 82781 46460262
Oculomucocutaneous syndrome 15.27 9.70 8 143011 143 46542900
Muscle spasticity 15.23 9.70 8 143011 11432 46531611
Foetal death 15.18 9.70 4 143015 8739 46534304
Chondropathy 15.17 9.70 24 142995 1946 46541097
Product quality issue 15.15 9.70 57 142962 35591 46507452
Abdominal pain upper 15.15 9.70 566 142453 144739 46398304
Vitamin K deficiency 15.02 9.70 12 143007 452 46542591
Progressive multifocal leukoencephalopathy 15.01 9.70 8 143011 11338 46531705
Insomnia 15.00 9.70 633 142386 164291 46378752
Hip surgery 14.99 9.70 27 142992 2433 46540610
Respiratory distress 14.93 9.70 49 142970 31867 46511176
Angina unstable 14.93 9.70 54 142965 7494 46535549
Coma 14.88 9.70 111 142908 58238 46484805
Emphysema 14.82 9.70 61 142958 8993 46534050
Erythema multiforme 14.81 9.70 64 142955 9640 46533403
Post procedural haemorrhage 14.58 9.70 53 142966 7373 46535670
Fracture pain 14.57 9.70 11 143008 381 46542662
Myelodysplastic syndrome 14.51 9.70 16 143003 15695 46527348
Migraine 14.50 9.70 298 142721 69728 46473315
Toe operation 14.42 9.70 13 143006 579 46542464
Dressler's syndrome 14.37 9.70 3 143016 0 46543043
Synovitis 14.37 9.70 265 142754 60810 46482233
Gluten sensitivity 14.19 9.70 12 143007 490 46542553
Lithotripsy 14.19 9.70 4 143015 10 46543033
Caesarean section 14.17 9.70 18 143001 16585 46526458
Spondylolisthesis 14.15 9.70 30 142989 3048 46539995
Tubo-ovarian abscess 14.15 9.70 10 143009 312 46542731
Neuralgia 14.13 9.70 113 142906 21270 46521773
Blood parathyroid hormone decreased 13.95 9.70 37 142982 4344 46538699
Immunoglobulins decreased 13.93 9.70 15 143004 831 46542212
Back pain 13.82 9.70 781 142238 209258 46333785
Therapeutic response decreased 13.81 9.70 197 142822 42948 46500095
Cognitive disorder 13.79 9.70 62 142957 36821 46506222
Pulmonary hypertension 13.76 9.70 60 142959 35933 46507110
Walking aid user 13.75 9.70 39 142980 4761 46538282
Nail injury 13.69 9.70 11 143008 418 46542625
Orthostatic hypotension 13.62 9.70 35 142984 24623 46518420
Ligament sprain 13.55 9.70 66 142953 10453 46532590
Cell marker increased 13.48 9.70 10 143009 337 46542706
Joint noise 13.44 9.70 30 142989 3157 46539886
Surgery 13.37 9.70 141 142878 28644 46514399
Pulmonary embolism 13.37 9.70 243 142776 108342 46434701
Blood calcium decreased 13.37 9.70 17 143002 15656 46527387
Psychotic disorder 13.37 9.70 31 142988 22590 46520453
Posterior reversible encephalopathy syndrome 13.36 9.70 16 143003 15125 46527918
Uterine perforation 13.25 9.70 3 143016 7264 46535779
Drug tolerance 13.25 9.70 30 142989 3188 46539855
Fear of injection 13.18 9.70 35 142984 4112 46538931
Status epilepticus 13.17 9.70 14 143005 13965 46529078
Blood bilirubin increased 13.06 9.70 57 142962 34127 46508916
Cartilage injury 13.06 9.70 20 142999 1577 46541466
Respiratory tract congestion 12.96 9.70 75 142944 12689 46530354
Tongue cancer recurrent 12.78 9.70 4 143015 16 46543027
Meningitis streptococcal 12.61 9.70 7 143012 141 46542902
Bronchomalacia 12.61 9.70 7 143012 141 46542902
Haemodynamic instability 12.56 9.70 4 143015 7721 46535322
Adrenal suppression 12.50 9.70 15 143004 936 46542107
Circulatory collapse 12.48 9.70 30 142989 21594 46521449
Eosinophilia 12.46 9.70 25 142994 19192 46523851
Electrolyte imbalance 12.42 9.70 21 142998 17205 46525838
Stenosis 12.33 9.70 14 143005 823 46542220
Neuroma 12.31 9.70 10 143009 386 46542657
Neuroprosthesis implantation 12.30 9.70 3 143016 3 46543040
Inflammation 12.30 9.70 214 142805 48567 46494476
Spinal deformity 12.29 9.70 15 143004 952 46542091
Periarticular disorder 12.21 9.70 5 143014 49 46542994
Pulmonary oedema 12.20 9.70 99 142920 51006 46492037
Lymphocyte count decreased 12.17 9.70 39 142980 25550 46517493
Rheumatoid factor positive 12.12 9.70 28 142991 20433 46522610
Dystonia 12.11 9.70 10 143009 11247 46531796
Flushing 12.07 9.70 133 142886 64481 46478562
Eye disorder 12.06 9.70 96 142923 18045 46524998
Wrist fracture 11.94 9.70 68 142951 11435 46531608
Haemorrhage subcutaneous 11.86 9.70 27 142992 2879 46540164
Tenosynovitis 11.80 9.70 50 142969 7465 46535578
Suicidal ideation 11.79 9.70 113 142906 56269 46486774
Small intestine ulcer 11.79 9.70 9 143010 317 46542726
Generalised tonic-clonic seizure 11.77 9.70 43 142976 27079 46515964
Transfusion 11.65 9.70 14 143005 13217 46529826
Miosis 11.64 9.70 3 143016 6654 46536389
Vertebral foraminal stenosis 11.64 9.70 14 143005 875 46542168
Gastric perforation 11.64 9.70 17 143002 1285 46541758
Accidental exposure to product 11.58 9.70 30 142989 21051 46521992
Joint dislocation 11.53 9.70 66 142953 11120 46531923
Device related infection 11.52 9.70 30 142989 21011 46522032
Acute respiratory failure 11.49 9.70 48 142971 29090 46513953
Spinal cord injury cervical 11.46 9.70 4 143015 24 46543019
Genital haemorrhage 11.41 9.70 3 143016 6563 46536480
Underdose 11.40 9.70 27 142992 19531 46523512
Coronary artery surgery 11.39 9.70 5 143014 59 46542984
Pulmonary congestion 11.35 9.70 81 142938 14718 46528325
Synovial rupture 11.34 9.70 7 143012 173 46542870
Coronary artery stenosis 11.33 9.70 36 142983 4677 46538366
Live birth 11.33 9.70 9 143010 10321 46532722
Disease risk factor 11.32 9.70 5 143014 60 46542983
Psoriasis 11.25 9.70 318 142701 78286 46464757
Parotid gland enlargement 11.22 9.70 13 143006 781 46542262
Brain oedema 11.21 9.70 13 143006 12465 46530578
Perseveration 11.17 9.70 8 143011 255 46542788
Axial spondyloarthritis 11.17 9.70 6 143013 113 46542930
Urinary tract pain 11.16 9.70 7 143012 178 46542865
Presyncope 11.13 9.70 38 142981 24416 46518627
Groin pain 11.05 9.70 56 142963 9009 46534034
Renal tubular necrosis 11.03 9.70 10 143009 10749 46532294
Rhabdomyolysis 11.03 9.70 79 142940 41830 46501213
Drug interaction 11.02 9.70 509 142510 202585 46340458
Hallucination, visual 10.96 9.70 24 142995 17849 46525194
Hepatic encephalopathy 10.95 9.70 9 143010 10148 46532895
Tendon rupture 10.95 9.70 50 142969 7709 46535334
Medication error 10.94 9.70 53 142966 30858 46512185
Back injury 10.83 9.70 46 142973 6875 46536168
Urinary tract infection 10.79 9.70 558 142461 219708 46323335
General physical health deterioration 10.77 9.70 271 142748 115498 46427545
Granuloma skin 10.74 9.70 29 142990 3441 46539602
Femur fracture 10.70 9.70 166 142853 36831 46506212
Mass excision 10.70 9.70 8 143011 273 46542770
Prescription drug used without a prescription 10.68 9.70 17 143002 1385 46541658
Dyspepsia 10.65 9.70 280 142739 68192 46474851
Panniculitis 10.60 9.70 40 142979 5664 46537379
Wrong technique in product usage process 10.58 9.70 111 142908 54311 46488732
Respiratory depression 10.51 9.70 12 143007 11588 46531455
Weight fluctuation 10.49 9.70 44 142975 6540 46536503
Interferon gamma release assay positive 10.47 9.70 4 143015 32 46543011
Unevaluable event 10.32 9.70 91 142928 46084 46496959
Necrotising fasciitis 10.30 9.70 24 142995 2599 46540444
Tendonitis 10.29 9.70 77 142942 14200 46528843
Ejection fraction decreased 10.26 9.70 25 142994 17912 46525131
Cervical spinal stenosis 10.25 9.70 20 142999 1915 46541128
Knee operation 10.20 9.70 35 142984 4731 46538312
Coeliac artery compression syndrome 10.18 9.70 6 143013 136 46542907
Wound 10.18 9.70 83 142936 42719 46500324
Anuria 10.17 9.70 12 143007 11419 46531624
Pneumonia aspiration 10.17 9.70 56 142963 31549 46511494
Inflammatory bowel disease 10.13 9.70 27 142992 3178 46539865
Compression fracture 10.12 9.70 42 142977 6215 46536828
Pathogen resistance 10.10 9.70 3 143016 6057 46536986
Mania 10.07 9.70 11 143008 10835 46532208
Road traffic accident 10.06 9.70 114 142905 23577 46519466
Laryngeal papilloma 10.01 9.70 3 143016 10 46543033
Respiratory papilloma 10.01 9.70 3 143016 10 46543033
Dyskinesia 10.00 9.70 50 142969 28875 46514168
Purpura senile 10.00 9.70 11 143008 624 46542419
Accidental overdose 9.95 9.70 30 142989 20036 46523007
Metastases to liver 9.92 9.70 29 142990 19556 46523487
Cutaneous symptom 9.91 9.70 6 143013 143 46542900
Aggression 9.91 9.70 36 142983 22708 46520335
Patellofemoral pain syndrome 9.90 9.70 10 143009 514 46542529
Medulloblastoma 9.88 9.70 4 143015 38 46543005
Oesophageal spasm 9.87 9.70 20 142999 1969 46541074
Tooth infection 9.86 9.70 68 142951 12218 46530825
Limb discomfort 9.86 9.70 110 142909 22666 46520377
Blood pressure systolic increased 9.84 9.70 133 142886 28654 46514389
Gastritis 9.84 9.70 154 142865 34224 46508819
No adverse event 9.77 9.70 63 142956 34168 46508875
Breast cyst 9.76 9.70 17 143002 1492 46541551
Asthma 9.71 9.70 210 142809 91332 46451711

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 312.77 10.33 484 51899 68035 29832060
Ankylosing spondylitis 230.54 10.33 126 52257 4408 29895687
Psoriatic arthropathy 149.12 10.33 160 52223 15601 29884494
Arthralgia 147.80 10.33 547 51836 135244 29764851
Death 135.52 10.33 263 52120 357020 29543075
Toxicity to various agents 129.00 10.33 75 52308 177108 29722987
Rheumatoid arthritis 123.53 10.33 242 52141 40955 29859140
Arthritis 116.22 10.33 176 52207 24225 29875870
Pain 114.83 10.33 600 51783 172041 29728054
Osteoarthritis 94.04 10.33 137 52246 18212 29881883
Drug abuse 84.26 10.33 20 52363 82052 29818043
Myocardial infarction 82.97 10.33 436 51947 125189 29774906
Back pain 73.95 10.33 365 52018 102231 29797864
Completed suicide 65.64 10.33 47 52336 99445 29800650
Arthropathy 64.83 10.33 124 52259 20603 29879492
Therapeutic product effect incomplete 57.43 10.33 159 52224 33675 29866420
Neck pain 55.57 10.33 117 52266 20827 29879268
Knee arthroplasty 52.96 10.33 57 52326 5573 29894522
Febrile neutropenia 50.09 10.33 68 52315 106625 29793470
Acute kidney injury 49.55 10.33 279 52104 273563 29626532
Drug ineffective 48.68 10.33 850 51533 339537 29560558
Joint swelling 46.68 10.33 184 52199 46762 29853333
Drug interaction 44.96 10.33 188 52195 199380 29700715
Intervertebral disc protrusion 44.30 10.33 67 52316 9204 29890891
Musculoskeletal stiffness 43.54 10.33 150 52233 35731 29864364
Coronary artery disease 39.49 10.33 182 52201 49530 29850565
Hypotension 39.19 10.33 199 52184 200366 29699729
Muscle swelling 39.00 10.33 17 52366 358 29899737
Thrombocytopenia 37.49 10.33 119 52264 136925 29763170
Ependymoma 37.29 10.33 11 52372 68 29900027
Psoriasis 37.06 10.33 160 52223 42346 29857749
Off label use 36.87 10.33 270 52113 249020 29651075
Exostosis 36.10 10.33 37 52346 3418 29896677
General physical health deterioration 35.59 10.33 76 52307 99868 29800227
Sacroiliitis 33.26 10.33 20 52363 840 29899255
Fibromyalgia 32.88 10.33 31 52352 2587 29897508
Cardio-respiratory arrest 31.73 10.33 32 52351 57274 29842821
Sepsis 31.04 10.33 141 52242 146254 29753841
Cerebral artery thrombosis 30.76 10.33 16 52367 505 29899590
Pain in extremity 30.18 10.33 310 52073 109911 29790184
Brain scan abnormal 30.05 10.33 17 52366 636 29899459
Lactic acidosis 29.38 10.33 9 52374 31204 29868891
Axial spondyloarthritis 29.15 10.33 11 52372 157 29899938
Therapeutic product effect decreased 28.92 10.33 114 52269 28962 29871133
Transposition of the great vessels 28.74 10.33 15 52368 477 29899618
Interstitial lung disease 28.72 10.33 192 52191 60005 29840090
Coronary artery stenosis 28.03 10.33 54 52329 9016 29891079
Hypoglycaemia 27.62 10.33 29 52354 50952 29849143
Anxiety 27.14 10.33 258 52125 89613 29810482
Neutropenia 27.13 10.33 124 52259 128416 29771679
Synovitis 26.35 10.33 55 52328 9728 29890367
Multiple organ dysfunction syndrome 26.35 10.33 44 52339 63443 29836652
Joint range of motion decreased 26.18 10.33 41 52342 5804 29894291
Pancytopenia 26.04 10.33 70 52313 84982 29815113
Cytomegalovirus infection 25.85 10.33 5 52378 23669 29876426
Intentional overdose 25.54 10.33 21 52362 41460 29858635
Overdose 25.38 10.33 70 52313 84267 29815828
Hypoaesthesia 25.29 10.33 172 52211 54058 29846037
Blood cholesterol increased 25.16 10.33 76 52307 16894 29883201
Intervertebral disc degeneration 25.16 10.33 38 52345 5213 29894882
Plasma cell myeloma 25.14 10.33 34 52349 53428 29846667
Hernia 24.77 10.33 50 52333 8636 29891459
Loss of personal independence in daily activities 24.37 10.33 88 52295 21447 29878648
Emotional distress 23.75 10.33 71 52312 15694 29884401
Gastric ulcer haemorrhage 23.42 10.33 37 52346 5277 29894818
Leukopenia 23.23 10.33 39 52344 56120 29843975
Foetal exposure during pregnancy 22.29 10.33 19 52364 36852 29863243
Grip strength decreased 22.26 10.33 23 52360 2145 29897950
Blood pressure increased 21.96 10.33 207 52176 71721 29828374
Blood pressure fluctuation 21.95 10.33 74 52309 17429 29882666
Epstein-Barr virus infection reactivation 21.74 10.33 10 52373 240 29899855
Xyphoid retraction 21.69 10.33 9 52374 167 29899928
Arachnoiditis 21.60 10.33 11 52372 332 29899763
Coronary artery occlusion 21.52 10.33 55 52328 11102 29888993
Osteopenia 21.37 10.33 33 52350 4615 29895480
Hyperkalaemia 21.22 10.33 53 52330 65957 29834138
Nasopharyngitis 20.87 10.33 175 52208 58674 29841421
Drug resistance 20.46 10.33 5 52378 20128 29879967
Victim of child abuse 20.32 10.33 10 52373 280 29899815
Spinal stenosis 20.28 10.33 31 52352 4298 29895797
Mass 20.24 10.33 41 52342 7099 29892996
Rotator cuff syndrome 20.24 10.33 35 52348 5378 29894717
Chest expansion decreased 19.76 10.33 8 52375 139 29899956
Hypokalaemia 19.72 10.33 36 52347 50156 29849939
Diarrhoea 19.42 10.33 441 51942 333662 29566433
Benign abdominal neoplasm 19.28 10.33 7 52376 89 29900006
Carpal tunnel syndrome 19.12 10.33 30 52353 4253 29895842
Abdominal discomfort 18.87 10.33 148 52235 48643 29851452
Fracture 18.85 10.33 36 52347 5970 29894125
Road traffic accident 18.68 10.33 69 52314 17002 29883093
Bradycardia 18.53 10.33 56 52327 65470 29834625
Inflammation 18.49 10.33 82 52301 21944 29878151
Hyperhidrosis 18.49 10.33 189 52194 66901 29833194
Joint space narrowing 18.38 10.33 6 52377 54 29900041
Depression 18.31 10.33 240 52143 90197 29809898
Heart rate decreased 18.27 10.33 79 52304 20915 29879180
Chest pain 18.24 10.33 298 52085 117329 29782766
Cardiac arrest 18.16 10.33 92 52291 92758 29807337
Gastric ulcer 18.15 10.33 63 52320 15058 29885037
Angina unstable 18.13 10.33 55 52328 12255 29887840
Foot deformity 18.09 10.33 26 52357 3411 29896684
Investigation abnormal 18.03 10.33 10 52373 360 29899735
Hip arthroplasty 17.83 10.33 27 52356 3713 29896382
Energy increased 17.75 10.33 16 52367 1260 29898835
Agitation 17.70 10.33 43 52340 54030 29846065
Peptic ulcer 17.69 10.33 23 52360 2745 29897350
Transient ischaemic attack 17.64 10.33 89 52294 25111 29874984
Musculoskeletal pain 17.44 10.33 103 52280 30837 29869258
Premature baby 17.25 10.33 4 52379 16687 29883408
Intervertebral disc disorder 16.95 10.33 18 52365 1733 29898362
Hepatic calcification 16.94 10.33 5 52378 31 29900064
Septic shock 16.83 10.33 56 52327 63551 29836544
Knee operation 16.82 10.33 16 52367 1350 29898745
Coma 16.81 10.33 28 52355 40421 29859674
Nervousness 16.74 10.33 52 52331 11736 29888359
Impaired work ability 16.71 10.33 33 52350 5610 29894485
Cerebrovascular accident 16.68 10.33 221 52162 83256 29816839
Oesophageal infection 16.26 10.33 8 52375 224 29899871
Gait disturbance 16.22 10.33 201 52182 74576 29825519
Small intestine ulcer 16.19 10.33 10 52373 441 29899654
Drug dependence 16.19 10.33 77 52306 21218 29878877
Spinal osteoarthritis 16.11 10.33 35 52348 6364 29893731
Gastrooesophageal reflux disease 16.05 10.33 104 52279 32151 29867944
Scoliosis 16.02 10.33 17 52366 1635 29898460
Lumbar spinal stenosis 15.87 10.33 21 52362 2549 29897546
Electrocardiogram QT prolonged 15.65 10.33 24 52359 35811 29864284
Suicide attempt 15.62 10.33 25 52358 36672 29863423
Platelet count decreased 15.60 10.33 115 52268 106014 29794081
Arteriosclerosis 15.58 10.33 48 52335 10785 29889310
Spinal disorder 15.52 10.33 24 52359 3361 29896734
Ankle fracture 15.51 10.33 25 52358 3626 29896469
Drug tolerance 15.46 10.33 19 52364 2143 29897952
Hepatic cirrhosis 15.32 10.33 62 52321 15937 29884158
Seizure 15.31 10.33 105 52278 98370 29801725
Hypomagnesaemia 15.24 10.33 5 52378 16593 29883502
Joint injury 15.10 10.33 35 52348 6642 29893453
Anaemia 14.91 10.33 265 52118 207727 29692368
Mucosal inflammation 14.73 10.33 19 52364 30475 29869620
Injury 14.69 10.33 76 52307 21655 29878440
Diverticulitis 14.68 10.33 65 52318 17380 29882715
Gastrointestinal haemorrhage 14.68 10.33 216 52167 83230 29816865
Orchitis noninfective 14.62 10.33 4 52379 18 29900077
Confusional state 14.60 10.33 158 52225 134676 29765419
Periarthritis 14.53 10.33 13 52370 1014 29899081
Spinal compression fracture 14.46 10.33 33 52350 6201 29893894
Brain neoplasm malignant 14.36 10.33 10 52373 541 29899554
Rhabdomyolysis 14.20 10.33 60 52323 63520 29836575
Myoclonus 14.14 10.33 3 52380 13309 29886786
Hyperbilirubinaemia 14.05 10.33 6 52377 16936 29883159
Blood creatinine increased 13.92 10.33 98 52285 91277 29808818
Iritis 13.71 10.33 14 52369 1288 29898807
Child abuse 13.66 10.33 7 52376 214 29899881
Renal failure 13.61 10.33 152 52231 128814 29771281
Facet joint syndrome 13.57 10.33 7 52376 217 29899878
Inadequate analgesia 13.55 10.33 20 52363 2688 29897407
Medulloblastoma 13.53 10.33 5 52378 67 29900028
Myalgia intercostal 13.52 10.33 4 52379 25 29900070
Hypoxia 13.45 10.33 41 52342 47813 29852282
Intermittent claudication 13.41 10.33 18 52365 2216 29897879
Drug withdrawal syndrome 13.20 10.33 69 52314 19740 29880355
Gingival ulceration 13.18 10.33 8 52375 342 29899753
Neuroleptic malignant syndrome 13.15 10.33 6 52377 16289 29883806
Mobility decreased 13.04 10.33 84 52299 25915 29874180
Nerve compression 13.03 10.33 20 52363 2782 29897313
Rebound psychosis 13.00 10.33 6 52377 145 29899950
Metabolic acidosis 12.89 10.33 29 52354 37432 29862663
Myofascial pain syndrome 12.85 10.33 8 52375 358 29899737
Amoebic dysentery 12.78 10.33 4 52379 31 29900064
Hepatitis chronic persistent 12.77 10.33 3 52380 6 29900089
Pulmonary tuberculosis 12.72 10.33 27 52356 4830 29895265
Fluid overload 12.60 10.33 9 52374 19083 29881012
Osteomyelitis 12.58 10.33 55 52328 14626 29885469
Duodenal ulcer 12.54 10.33 42 52341 9859 29890236
Mitral valve incompetence 12.45 10.33 51 52332 13183 29886912
Agranulocytosis 12.43 10.33 12 52371 21930 29878165
Cardiogenic shock 12.43 10.33 7 52376 16854 29883241
Aggression 12.36 10.33 29 52354 36878 29863217
Hypercholesterolaemia 12.21 10.33 35 52348 7557 29892538
Drug abuser 12.15 10.33 25 52358 4376 29895719
Stab wound 12.06 10.33 6 52377 172 29899923
Back disorder 12.03 10.33 30 52353 5964 29894131
Sciatica 11.97 10.33 27 52356 5034 29895061
Generalised tonic-clonic seizure 11.90 10.33 10 52373 19541 29880554
Dyspepsia 11.72 10.33 92 52291 30237 29869858
Haematochezia 11.72 10.33 101 52282 34121 29865974
Herpes zoster 11.67 10.33 91 52292 29852 29870243
Drug level increased 11.66 10.33 9 52374 18345 29881750
Pyrexia 11.63 10.33 410 51973 294079 29606016
Drug reaction with eosinophilia and systemic symptoms 11.58 10.33 20 52363 28468 29871627
Inflammatory bowel disease 11.57 10.33 17 52366 2276 29897819
Hyperglycaemia 11.51 10.33 28 52355 35172 29864923
Blood bilirubin increased 11.32 10.33 30 52353 36606 29863489
Chronic idiopathic pain syndrome 11.24 10.33 3 52380 12 29900083
Erythema multiforme 11.13 10.33 35 52348 7950 29892145
Hyperlipidaemia 11.09 10.33 51 52332 13856 29886239
Cardiac failure 11.04 10.33 93 52290 83325 29816770
Adhesion 11.03 10.33 9 52374 619 29899476
Therapy non-responder 10.80 10.33 22 52361 29431 29870664
Status epilepticus 10.77 10.33 3 52380 11069 29889026
Application site rash 10.76 10.33 10 52373 819 29899276
Oesophagogastric fundoplasty 10.70 10.33 3 52380 15 29900080
Ascites 10.66 10.33 30 52353 35891 29864204
Skin irritation 10.63 10.33 23 52360 4169 29895926
Inflammatory pain 10.60 10.33 4 52379 57 29900038
Prostate cancer 10.58 10.33 75 52308 23882 29876213
Retro-orbital neoplasm 10.54 10.33 3 52380 16 29900079
Atypical teratoid/rhabdoid tumour of CNS 10.54 10.33 3 52380 16 29900079
Ankle operation 10.43 10.33 6 52377 232 29899863
Cyst 10.42 10.33 22 52361 3921 29896174

Pharmacologic Action:

SourceCodeDescription
ATC C08CA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC L01XX33 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Other antineoplastic agents
ATC M01AH01 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D052246 Cyclooxygenase 2 Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:50629 cyclooxygenase-2 inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatoid arthritis indication 69896004 DOID:7148
Dysmenorrhea indication 266599000
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001
Acute postoperative pain indication 107401000119105
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Gastrointestinal hemorrhage contraindication 74474003
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.79 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 10MG BASE;200MG CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINULLTION
EQ 2.5MG BASE;200MG CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINULLTION
EQ 5MG BASE;200MG CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINULLTION
25MG/ML ELYXYB DR REDDYS N212157 May 5, 2020 DISCN SOLUTION ORAL May 5, 2023 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.24 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 5.48 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.14 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 6.16 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 4.92 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 4.86 DRUG MATRIX
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Enzyme IC50 5.03 DRUG MATRIX
Carbonic anhydrase 2 Enzyme IC50 7.68 WOMBAT-PK
Sodium-dependent dopamine transporter Transporter Ki 6.18 WOMBAT-PK
Carbonic anhydrase 12 Enzyme Ki 7.74 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.06 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 7.01 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 7.30 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.13 CHEMBL
3-phosphoinositide-dependent protein kinase 1 Kinase IC50 4.32 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.10 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 6.16 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 5.66 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.80 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 4.30 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 7.03 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 7.03 CHEMBL
Mitogen-activated protein kinase 14 Kinase IC50 6.09 CHEMBL
D(1A) dopamine receptor GPCR Ki 4.85 DRUG MATRIX
Progesterone receptor Transcription factor Ki 5.63 DRUG MATRIX
Prostaglandin G/H synthase 2 Enzyme IC50 7.40 CHEMBL
Cytochrome c oxidase subunit 2 Enzyme IC50 7.22 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 8.43 CHEMBL
Carbonic anhydrase Enzyme Ki 4.41 CHEMBL
Alpha carbonic anhydrase Unclassified Ki 7.47 CHEMBL
Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase Enzyme Ki 5.11 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.24 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 9.29 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 9.15 CHEMBL
Astrosclerin-3 Unclassified Ki 6.14 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.96 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 4.99 CHEMBL
Carbonic anhydrase Unclassified Ki 6.16 CHEMBL
Delta carbonic anhydrase Unclassified Ki 6.58 CHEMBL
Carbonic anhydrase Enzyme Ki 6.97 CHEMBL
Cyclooxygenase 2; Prostaglandin G/H synthase-2; Uncharacterized protein Enzyme IC50 6.05 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.25 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.85 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 7.35 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.11 CHEMBL
Cytochrome c oxidase subunit 1 Unclassified IC50 4.61 CHEMBL
Carbonic anhydrase Enzyme Ki 7.68 CHEMBL
Carbonic anhydrase Enzyme Ki 6.85 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 6.15 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.54 CHEMBL
Carbonic anhydrase Unclassified Ki 6.76 CHEMBL
Carbonic anhydrase Enzyme Ki 6.94 CHEMBL

External reference:

IDSource
4021143 VUID
N0000148596 NUI
D00567 KEGG_DRUG
4021143 VANDF
C0719198 UMLSCUI
CHEBI:41423 CHEBI
CEL PDB_CHEM_ID
CHEMBL118 ChEMBL_ID
DB00482 DRUGBANK_ID
D000068579 MESH_DESCRIPTOR_UI
2662 PUBCHEM_CID
2892 IUPHAR_LIGAND_ID
7767 INN_ID
JCX84Q7J1L UNII
140587 RXNORM
14020 MMSL
174627 MMSL
7872 MMSL
d04380 MMSL
007731 NDDF
116081000 SNOMEDCT_US
370187009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1515 CAPSULE 50 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1520 CAPSULE 100 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1525 CAPSULE 200 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1530 CAPSULE 400 mg ORAL NDA 31 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7165 CAPSULE 100 mg ORAL ANDA 29 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7166 CAPSULE 200 mg ORAL ANDA 29 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7170 CAPSULE 400 mg ORAL ANDA 29 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7306 CAPSULE 50 mg ORAL ANDA 29 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7150 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7160 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7165 CAPSULE 50 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7170 CAPSULE 400 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3982 CAPSULE 50 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3983 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3984 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3985 CAPSULE 400 mg ORAL ANDA 30 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0615-8297 CAPSULE 200 mg ORAL ANDA 26 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0615-8338 CAPSULE 200 mg ORAL ANDA 26 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0904-6502 CAPSULE 100 mg ORAL ANDA 31 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0904-6503 CAPSULE 200 mg ORAL ANDA 31 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-917 CAPSULE 200 mg ORAL NDA authorized generic 33 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-918 CAPSULE 200 mg ORAL NDA authorized generic 33 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-929 CAPSULE 200 mg ORAL NDA authorized generic 33 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-953 CAPSULE 200 mg ORAL ANDA 33 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-967 CAPSULE 200 mg ORAL NDA authorized generic 33 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-307 CAPSULE 50 mg ORAL ANDA 27 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-310 CAPSULE 400 mg ORAL ANDA 27 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-441 CAPSULE 100 mg ORAL ANDA 27 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-442 CAPSULE 200 mg ORAL ANDA 27 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 16590-045 CAPSULE 100 mg ORAL NDA 33 sections