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ethenzamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| analgesic anti-inflammatory | 1080 | 938-73-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 3 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.135 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.332 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 115.080 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 40.551 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 51.440 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 74.950 | % | High | 1 |
| herg | hERG pIC50 | 3.846 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 9.354 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 38.194 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 54.930 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,MAP3K21,MAP3K7,MAPK7,MARK4,MTOR,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK,ULK1 | 36 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CDK9,GRK2,JAK1,MAP3K21,MAPK7,SIK2,SIK3 | 10 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.590 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 97.051 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 72.450 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.231 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 49.710 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 18.750 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 96.160 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 62.670 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 839.460 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N02BA07 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Salicylic acid and derivatives |
| ATC | N02BA57 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Salicylic acid and derivatives |
| ATC | N02BA77 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Salicylic acid and derivatives |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| CHEBI has role | CHEBI:35480 | analgesic |
Related Drugs by ATC class:
N02BA Salicylic acid and derivatives 11 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.73 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D01466 | KEGG_DRUG |
| C0059708 | UMLSCUI |
| CHEBI:31564 | CHEBI |
| CHEMBL1483877 | ChEMBL_ID |
| DB13544 | DRUGBANK_ID |
| 3282 | PUBCHEM_CID |
| 903 | INN_ID |
| C018935 | MESH_SUPPLEMENTAL_RECORD_UI |
| L929ZCK4BF | UNII |
| 24468 | RXNORM |
| 005662 | NDDF |
| 712687008 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Penzal Q | HUMAN OTC DRUG LABEL | 3 | 72689-0034 | TABLET | 200 mg | ORAL | OTC monograph not final | 7 sections |