paracetamol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
52 103-90-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetaminophen
  • acetaminofen
  • aminofen
  • panadol
  • paracetamol
  • neopap
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
  • Molecular weight: 151.17
  • Formula: C8H9NO2
  • CLOGP: 0.49
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 49.33
  • ALOGS: -1.56
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g O
3 g P
3 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 23.70 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 330.76 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.52 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,JAK3,KIT,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 60
kinase-selectivity-class ACVR2A,ACVR2B,AURKA,AXL,CAMK2D,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,MAP2K3,MAP2K6,MAPK7,MARK4,PIK3CB,SIK2,STK33,TEK,TTK,ULK1 21
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.774 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.474 % High 1

Approvals:

DateAgencyCompanyOrphan
Nov. 7, 1968 FDA POLYMEDICA
Feb. 24, 2023 PMDA AYUMI PHARMACEUTICAL CORPORATION

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 4687.34 10.26 11678 1275932 276168 89064669
Intentional overdose 2679.26 10.26 4794 1282816 89040 89251797
Completed suicide 2293.65 10.26 5825 1281785 139233 89201604
Acute hepatic failure 1754.88 10.26 1873 1285737 20688 89320149
Exposure to toxic agent 1485.46 10.26 1087 1286523 6880 89333957
Overdose 1394.13 10.26 5167 1282443 152542 89188295
Analgesic drug level increased 1152.94 10.26 640 1286970 2279 89338558
Suicide attempt 1072.63 10.26 2912 1284698 72487 89268350
Poisoning deliberate 1018.10 10.26 1214 1286396 15272 89325565
Drug ineffective 903.60 10.26 14052 1273558 1370246 87970591
Hepatocellular injury 743.48 10.26 1414 1286196 27544 89313293
Metabolic acidosis 695.70 10.26 2052 1285558 53624 89287213
Hepatic cytolysis 586.37 10.26 1333 1286277 29583 89311254
Intentional product misuse 468.28 10.26 2511 1285099 87093 89253744
Injection site pain 462.94 10.26 1121 1286489 172578 89168259
Blood pressure fluctuation 391.92 10.26 1630 1285980 50783 89290054
Device expulsion 380.28 10.26 62 1287548 40824 89300013
Cholestasis 377.04 10.26 1255 1286355 35044 89305793
Myelosuppression 319.06 10.26 182 1287428 53409 89287428
Coma 314.37 10.26 1936 1285674 70696 89270141
Somnolence 300.30 10.26 4401 1283209 204683 89136154
Product dose omission issue 299.46 10.26 2674 1284936 289013 89051824
Infusion related reaction 275.96 10.26 7814 1279796 408966 88931871
Hepatic failure 271.20 10.26 1202 1286408 38526 89302311
Throat irritation 253.93 10.26 1364 1286246 47331 89293506
Injection site erythema 246.64 10.26 656 1286954 97846 89242991
Pyroglutamic acidosis 239.42 10.26 175 1287435 1105 89339732
Suspected suicide attempt 239.39 10.26 153 1287457 748 89340089
Depressed level of consciousness 233.67 10.26 1803 1285807 70981 89269856
Prothrombin time ratio decreased 230.32 10.26 155 1287455 840 89339997
Anion gap 224.70 10.26 161 1287449 981 89339856
Coagulopathy 218.98 10.26 779 1286831 22510 89318327
Hepatotoxicity 197.14 10.26 1220 1286390 44622 89296215
Disease progression 192.41 10.26 1367 1286243 155248 89185589
Drug resistance 183.27 10.26 102 1287508 30347 89310490
Accidental overdose 177.77 10.26 835 1286775 27438 89313399
Blood pressure diastolic abnormal 177.59 10.26 654 1286956 19227 89321610
Hepatitis fulminant 176.89 10.26 248 1287362 3697 89337140
Hepatitis acute 175.75 10.26 441 1287169 10446 89330391
Blood pressure systolic abnormal 168.36 10.26 634 1286976 18844 89321993
Drug hypersensitivity 164.70 10.26 5173 1282437 458436 88882401
Suspected suicide 163.37 10.26 396 1287214 9172 89331665
Therapeutic product effect incomplete 160.65 10.26 1870 1285740 192026 89148811
Alopecia 158.93 10.26 5596 1282014 489475 88851362
Body temperature increased 156.20 10.26 1130 1286480 43580 89297257
Prothrombin time shortened 154.41 10.26 176 1287434 2102 89338735
Oxygen saturation decreased 154.41 10.26 2263 1285347 105220 89235617
Therapy interrupted 151.86 10.26 301 1287309 49807 89291030
Wrong technique in product usage process 151.59 10.26 515 1287095 71056 89269781
Hospitalisation 148.76 10.26 1136 1286474 126964 89213873
Heart rate increased 148.26 10.26 2341 1285269 110561 89230276
Blood pressure systolic increased 145.86 10.26 1367 1286243 56978 89283859
Injection site swelling 145.66 10.26 404 1287206 59435 89281402
Injection site reaction 144.45 10.26 744 1286866 91336 89249501
Sinusitis 141.58 10.26 6093 1281517 336995 89003842
International normalised ratio increased 138.15 10.26 1147 1286463 46169 89294668
Medication error 135.99 10.26 1818 1285792 82834 89258003
Heart rate decreased 134.96 10.26 1256 1286354 52249 89288588
Ear pruritus 134.20 10.26 298 1287312 6505 89334332
Malignant neoplasm progression 134.09 10.26 927 1286683 105943 89234894
Pyroglutamate increased 132.10 10.26 75 1287535 282 89340555
Vomiting 130.76 10.26 12946 1274664 775347 88565490
Treatment failure 129.00 10.26 3308 1284302 300620 89040217
Injection site pruritus 128.42 10.26 367 1287243 53467 89287370
Blood pressure increased 125.13 10.26 3679 1283931 193538 89147299
Product use in unapproved indication 123.64 10.26 3734 1283876 332502 89008335
Poisoning 121.47 10.26 483 1287127 14734 89326103
Intentional self-injury 121.34 10.26 773 1286837 28561 89312276
Red blood cell sedimentation rate abnormal 119.16 10.26 101 1287509 24103 89316734
Cardiac failure congestive 118.98 10.26 866 1286744 97828 89243009
Maternal exposure during pregnancy 116.34 10.26 4066 1283544 355997 88984840
Injection site bruising 115.17 10.26 370 1287240 51937 89288900
Therapy non-responder 112.20 10.26 1321 1286289 135383 89205454
Off label use 110.95 10.26 13844 1273766 1088408 88252429
Rheumatoid arthritis 110.76 10.26 6254 1281356 356360 88984477
Lower respiratory tract infection 109.56 10.26 4479 1283131 246180 89094657
Drug abuse 108.68 10.26 1709 1285901 80638 89260199
Transaminases increased 104.56 10.26 894 1286716 36298 89304539
Urine abnormality 104.19 10.26 293 1287317 7444 89333393
Respiratory depression 103.85 10.26 468 1287142 15107 89325730
Confusional state 102.01 10.26 6576 1281034 379629 88961208
Mixed liver injury 101.99 10.26 288 1287322 7335 89333502
Hepatic encephalopathy 101.91 10.26 427 1287183 13345 89327492
Acute generalised exanthematous pustulosis 101.50 10.26 425 1287185 13278 89327559
Accidental exposure to product 100.92 10.26 289 1287321 42077 89298760
Blood pressure diastolic decreased 99.53 10.26 688 1286922 26138 89314699
Psoriasis 98.61 10.26 1490 1286120 146264 89194573
Cardio-respiratory arrest 95.68 10.26 1342 1286268 61798 89279039
Therapy cessation 94.96 10.26 237 1287373 36124 89304713
Condition aggravated 94.71 10.26 7231 1280379 588314 88752523
Cholecystitis chronic 94.37 10.26 331 1287279 9495 89331342
Device dislocation 93.78 10.26 191 1287419 31291 89309546
Hepatic necrosis 92.85 10.26 250 1287360 6188 89334649
Hepatitis cholestatic 92.48 10.26 300 1287310 8261 89332576
Miosis 92.41 10.26 321 1287289 9163 89331674
Cytokine release syndrome 92.02 10.26 697 1286913 27276 89313561
Hypocoagulable state 91 10.26 113 1287497 1486 89339351
Abdominal pain 90.45 10.26 6658 1280952 389063 88951774
Ductus arteriosus premature closure 88.57 10.26 62 1287548 362 89340475
Urine leukocyte esterase positive 85.14 10.26 161 1287449 3121 89337716
Device difficult to use 84.01 10.26 75 1287535 17450 89323387
Abdominal discomfort 83.70 10.26 5747 1281863 471581 88869256
Therapeutic response decreased 83.65 10.26 842 1286768 88887 89251950
Hypotension 82.36 10.26 5521 1282089 319876 89020961
Drug level increased 82.12 10.26 675 1286935 27087 89313750
Surgery 82.04 10.26 343 1287267 44544 89296293
Systemic lupus erythematosus 81.39 10.26 4256 1283354 357640 88983197
Haematotoxicity 79.87 10.26 39 1287571 12496 89328341
Acute kidney injury 79.84 10.26 5429 1282181 314958 89025879
Neoplasm progression 78.81 10.26 344 1287266 44142 89296695
Alanine aminotransferase increased 77.33 10.26 2216 1285394 116122 89224715
Multiple-drug resistance 76.46 10.26 10 1287600 7766 89333071
Transplant rejection 76.40 10.26 43 1287567 12715 89328122
Post transplant lymphoproliferative disorder 75.93 10.26 6 1287604 6943 89333894
Metastases to liver 75.04 10.26 188 1287422 28619 89312218
Infusion site pruritus 74.83 10.26 239 1287371 6526 89334311
Hepatitis 74.53 10.26 1416 1286194 69323 89271514
Encephalopathy 73.98 10.26 996 1286614 45448 89295389
Bradypnoea 73.43 10.26 187 1287423 4471 89336366
Product storage error 72.84 10.26 109 1287501 20132 89320705
Diarrhoea 72.26 10.26 11986 1275624 927204 88413633
Psoriatic arthropathy 71.95 10.26 2586 1285024 225749 89115088
Infusion site erythema 71.31 10.26 383 1287227 13287 89327550
Abortion spontaneous 71.24 10.26 462 1287148 53594 89287243
Bone marrow failure 70.88 10.26 228 1287382 31993 89308844
Pemphigus 70.30 10.26 3861 1283749 323003 89017834
Lymphocyte count decreased 70.29 10.26 785 1286825 34265 89306572
Infusion site swelling 69.24 10.26 340 1287270 11380 89329457
Blood parathyroid hormone decreased 69.18 10.26 44 1287566 12172 89328665
Prothrombin time prolonged 68.46 10.26 298 1287312 9474 89331363
Device malfunction 67.97 10.26 121 1287489 20856 89319981
White blood cells urine positive 67.77 10.26 225 1287385 6273 89334564
Nasopharyngitis 67.26 10.26 6686 1280924 400418 88940419
Posterior reversible encephalopathy syndrome 66.99 10.26 135 1287475 22204 89318633
Brain oedema 66.95 10.26 450 1287160 16935 89323902
Infusion site pain 66.72 10.26 495 1287115 19243 89321594
Drug dose omission by device 66.46 10.26 31 1287579 10200 89330637
Fixed eruption 66.32 10.26 101 1287509 1629 89339208
Pathogen resistance 65.76 10.26 17 1287593 8098 89332739
Drug ineffective for unapproved indication 65.65 10.26 617 1286993 66027 89274810
Acute lung injury 65.43 10.26 93 1287517 1405 89339432
Blood pressure diastolic increased 64.90 10.26 358 1287252 12548 89328289
Renal impairment 64.66 10.26 1080 1286530 104341 89236496
Unintentional medical device removal 64.62 10.26 11 1287599 7019 89333818
Toxic epidermal necrolysis 64.54 10.26 727 1286883 31801 89309036
Cytomegalovirus infection 64.44 10.26 180 1287430 26422 89314415
Pyrexia 64.15 10.26 10498 1277112 649987 88690850
Tachycardia 63.55 10.26 2794 1284816 154879 89185958
Injection site haemorrhage 63.26 10.26 199 1287411 28119 89312718
Device issue 62.91 10.26 212 1287398 29325 89311512
Crystal urine present 62.88 10.26 91 1287519 1399 89339438
Unevaluable event 62.43 10.26 489 1287121 54359 89286478
Muscle spasticity 62.37 10.26 772 1286838 34550 89306287
Therapy partial responder 62.10 10.26 138 1287472 21905 89318932
Myocardial infarction 61.98 10.26 1095 1286515 104877 89235960
Breast cancer female 61.92 10.26 72 1287538 14814 89326023
Cardiac failure 61.65 10.26 1139 1286471 108357 89232480
Palmar-plantar erythrodysaesthesia syndrome 60.46 10.26 200 1287410 27823 89313014
Drug tolerance 60.19 10.26 101 1287509 17815 89323022
Urinary sediment present 59.34 10.26 109 1287501 2065 89338772
Metastases to bone 59.28 10.26 176 1287434 25329 89315508
Rheumatoid nodule 58.67 10.26 124 1287486 20042 89320795
Breast cancer stage I 56.83 10.26 33 1287577 9591 89331246
Loss of personal independence in daily activities 56.71 10.26 1485 1286125 134620 89206217
Granuloma skin 55.79 10.26 42 1287568 10638 89330199
Thrombotic microangiopathy 55.48 10.26 86 1287524 15657 89325180
Pharyngeal paraesthesia 53.80 10.26 131 1287479 3043 89337794
Joint destruction 53.42 10.26 66 1287544 13221 89327616
Full blood count abnormal 53.35 10.26 303 1287307 36294 89304543
Injection site warmth 53.25 10.26 105 1287505 17410 89323427
Respiratory arrest 52.90 10.26 714 1286896 32597 89308240
Rash maculo-papular 52.67 10.26 846 1286764 40087 89300750
Genital haemorrhage 52.59 10.26 29 1287581 8673 89332164
Orthostatic hypotension 52.53 10.26 861 1286749 40966 89299871
Injection site urticaria 52.19 10.26 111 1287499 17900 89322937
Skin necrosis 51.99 10.26 101 1287509 16840 89323997
Neutropenia 51.83 10.26 2638 1284972 222266 89118571
Respiratory rate increased 51.68 10.26 397 1287213 15604 89325233
No adverse event 51.58 10.26 668 1286942 67314 89273523
Acidosis 51.07 10.26 333 1287277 12403 89328434
Panniculitis 50.93 10.26 79 1287531 14379 89326458
Ill-defined disorder 50.89 10.26 3160 1284450 181731 89159106
Contraindicated product administered 49.99 10.26 3892 1283718 316247 89024590
Red blood cells urine positive 49.32 10.26 128 1287482 3097 89337740
Brain death 49.07 10.26 147 1287463 3874 89336963
Analgesic drug level above therapeutic 48.65 10.26 30 1287580 136 89340701
Infusion site extravasation 48.31 10.26 281 1287329 10047 89330790
Ovarian hyperstimulation syndrome 48.04 10.26 12 1287598 5850 89334987
Myelodysplastic syndrome 48.03 10.26 145 1287465 20758 89320079
Metastases to lung 47.64 10.26 97 1287513 15894 89324943
Disturbance in social behaviour 47.54 10.26 3 1287607 4185 89336652
Anaemia 47.30 10.26 4341 1283269 348461 88992376
Diabetes mellitus 47.21 10.26 643 1286967 64232 89276605
Oligohydramnios 46.98 10.26 215 1287395 6986 89333851
Product quality issue 46.91 10.26 818 1286792 78507 89262330
Renal papillary necrosis 46.82 10.26 36 1287574 248 89340589
Anion gap abnormal 45.87 10.26 40 1287570 336 89340501
Blister 45.78 10.26 4213 1283397 250785 89090052
Folliculitis 45.56 10.26 3432 1284178 200921 89139916
Premature delivery 45.33 10.26 343 1287267 38419 89302418
Basal cell carcinoma 45.21 10.26 283 1287327 33106 89307731
Hypothermia 45.16 10.26 377 1287233 15198 89325639
Poor venous access 45.10 10.26 450 1287160 19077 89321760
Injection site rash 44.62 10.26 184 1287426 23989 89316848
Injection site mass 44.07 10.26 163 1287447 21927 89318910
Chills 43.71 10.26 2294 1285316 129687 89211150
Cardiotoxicity 43.29 10.26 59 1287551 11330 89329507
Sleep disorder due to general medical condition, insomnia type 43.26 10.26 2240 1285370 126454 89214383
Exposure via ingestion 43.01 10.26 108 1287502 2559 89338278
Jaundice 42.95 10.26 675 1286935 31842 89308995
Sleep disorder due to a general medical condition 42.45 10.26 418 1287192 44320 89296517
Schizoaffective disorder 42.40 10.26 165 1287445 4982 89335855
Glossodynia 42.17 10.26 3966 1283644 317813 89023024
Bronchial secretion retention 42.09 10.26 130 1287480 3485 89337352
Sensitisation 41.95 10.26 5 1287605 4170 89336667
Wrong patient received product 41.38 10.26 126 1287484 3351 89337486
Flushing 41.35 10.26 1593 1286017 86898 89253939
Muscle injury 41.26 10.26 2978 1284632 173676 89167161
Osteonecrosis 41.15 10.26 212 1287398 26029 89314808
Coagulation factor V level decreased 41.15 10.26 37 1287573 325 89340512
Dry skin 41.03 10.26 945 1286665 87128 89253709
Systemic infection 40.66 10.26 9 1287601 4766 89336071
Cholelithiasis 40.54 10.26 1005 1286605 51501 89289336
Depression 40.38 10.26 3698 1283912 296903 89043934
Disease recurrence 39.97 10.26 342 1287268 37311 89303526
Blood urine present 39.82 10.26 398 1287212 16880 89323957
Ear pain 39.77 10.26 1088 1286522 56614 89284223
Oedema 39.57 10.26 2385 1285225 197910 89142927
Mucosal inflammation 39.50 10.26 578 1287032 57047 89283790
Stevens-Johnson syndrome 39.26 10.26 611 1286999 28765 89312072
Hypothyroidism 39.22 10.26 525 1287085 52602 89288235
Second primary malignancy 39.21 10.26 54 1287556 10324 89330513
Injection site induration 39.02 10.26 55 1287555 10413 89330424
Seizure 38.95 10.26 1771 1285839 150858 89189979
Jaundice cholestatic 38.70 10.26 260 1287350 9783 89331054
Creatinine renal clearance decreased 38.68 10.26 425 1287185 18474 89322363
Tardive dyskinesia 38.24 10.26 60 1287550 10870 89329967
Irritable bowel syndrome 38.23 10.26 3434 1284176 204014 89136823
Medication overuse headache 38.16 10.26 73 1287537 1428 89339409
Haemophagocytic lymphohistiocytosis 37.89 10.26 104 1287506 15355 89325482
Lymphocyte percentage decreased 37.86 10.26 114 1287496 3013 89337824
Complication of device insertion 37.75 10.26 56 1287554 10380 89330457
Drug use disorder 37.74 10.26 225 1287385 8118 89332719
Neuropathy peripheral 37.70 10.26 1576 1286034 135394 89205443
Blood iron abnormal 37.60 10.26 6 1287604 4014 89336823
Neurotoxicity 37.42 10.26 167 1287443 21300 89319537
Mucormycosis 37.36 10.26 5 1287605 3816 89337021
Hepatitis toxic 37.09 10.26 127 1287483 3598 89337239
Product prescribing error 37.05 10.26 263 1287347 29882 89310955
Aspartate aminotransferase increased 36.93 10.26 1803 1285807 101134 89239703
White blood cell count decreased 36.61 10.26 1970 1285640 165139 89175698
Product substitution issue 36.50 10.26 132 1287478 17876 89322961
Blood calcium decreased 36.32 10.26 617 1286993 29565 89311272
Drug-induced liver injury 36.05 10.26 1599 1286011 88719 89252118
Heart rate irregular 36.04 10.26 514 1287096 23754 89317083
Sedation complication 35.59 10.26 383 1287227 16561 89324276
Aspergillus infection 35.46 10.26 62 1287548 10761 89330076
Underdose 35.24 10.26 547 1287063 53470 89287367
Breast cancer 35.21 10.26 544 1287066 53217 89287620
Mydriasis 35.18 10.26 347 1287263 14665 89326172
Respiratory failure 34.85 10.26 1352 1286258 117066 89223771
Chronic graft versus host disease 34.85 10.26 8 1287602 4131 89336706
Acute graft versus host disease in skin 34.83 10.26 12 1287598 4744 89336093
Hypertransaminasaemia 34.78 10.26 361 1287249 15464 89325373
Ductus arteriosus stenosis foetal 34.68 10.26 28 1287582 209 89340628
Back pain 34.47 10.26 5074 1282536 312101 89028736
Rheumatoid lung 34.41 10.26 8 1287602 4095 89336742
Transplant dysfunction 34.32 10.26 16 1287594 5266 89335571
Urticaria 34.23 10.26 5005 1282605 307729 89033108
Drug intolerance 34.06 10.26 5714 1281896 441877 88898960
Coagulation factor decreased 34.06 10.26 26 1287584 177 89340660
Oropharyngeal pain 33.99 10.26 1981 1285629 113206 89227631
Interstitial lung disease 33.60 10.26 827 1286783 75578 89265259
Leukopenia 33.44 10.26 1133 1286477 99577 89241260
Foot deformity 33.41 10.26 621 1286989 59030 89281807
Cytopenia 33.35 10.26 131 1287479 17318 89323519
Graft versus host disease in skin 33.35 10.26 7 1287603 3846 89336991
Eosinophilia 33.15 10.26 580 1287030 27953 89312884
Polyarthritis 33.05 10.26 141 1287469 18209 89322628
Headache 32.97 10.26 13163 1274447 849583 88491254
Chest discomfort 32.73 10.26 2335 1285275 136030 89204807
Infusion site rash 32.43 10.26 93 1287517 2390 89338447
Neoplasm malignant 32.37 10.26 316 1287294 33564 89307273
Product monitoring error 32.37 10.26 12 1287598 4532 89336305
Device use error 32.16 10.26 33 1287577 7188 89333649
Haemoglobin urine present 31.90 10.26 47 1287563 735 89340102
Upper gastrointestinal haemorrhage 31.90 10.26 481 1287129 22495 89318342
Blood alkaline phosphatase increased 31.86 10.26 902 1286708 47177 89293660
Blood bilirubin increased 31.78 10.26 826 1286784 42644 89298193
Unintended pregnancy 31.70 10.26 37 1287573 7600 89333237
Meningitis aseptic 31.50 10.26 184 1287426 6589 89334248
Toxic skin eruption 31.50 10.26 353 1287257 15421 89325416
Visceral congestion 31.43 10.26 33 1287577 357 89340480
Memory impairment 31.38 10.26 2394 1285216 194850 89145987
Neutrophil percentage increased 31.33 10.26 104 1287506 2899 89337938
Gastrointestinal toxicity 31.23 10.26 54 1287556 9413 89331424
Complication associated with device 31.14 10.26 156 1287454 19293 89321544
Pruritus 31.13 10.26 8394 1279216 533131 88807706
Coagulation factor VII level decreased 30.88 10.26 18 1287592 72 89340765
Musculoskeletal disorder 30.78 10.26 182 1287428 21587 89319250
Lupus-like syndrome 30.74 10.26 498 1287112 48348 89292489
Acute graft versus host disease 30.55 10.26 20 1287590 5448 89335389
Septic shock 30.28 10.26 937 1286673 83223 89257614
Exposure via skin contact 30.17 10.26 67 1287543 10638 89330199
Serotonin syndrome 30.09 10.26 728 1286882 37159 89303678
Cytomegalovirus infection reactivation 30.06 10.26 40 1287570 7760 89333077
Nasal necrosis 30.06 10.26 20 1287590 106 89340731
Clostridium test positive 30.01 10.26 154 1287456 5247 89335590
Product preparation error 29.93 10.26 63 1287547 10198 89330639
Enthesopathy 29.79 10.26 55 1287555 9349 89331488
Varicella zoster virus infection 29.78 10.26 9 1287601 3868 89336969
Hypercalcaemia 29.59 10.26 327 1287283 33913 89306924
Diabetic ketoacidosis 29.48 10.26 214 1287396 24193 89316644
Specific gravity urine decreased 29.46 10.26 46 1287564 759 89340078
Visual acuity reduced 29.38 10.26 203 1287407 23207 89317630
Pneumocystis jirovecii pneumonia 29.37 10.26 183 1287427 21433 89319404
Type I hypersensitivity 29.33 10.26 127 1287483 4028 89336809
Diffuse large B-cell lymphoma recurrent 29.32 10.26 7 1287603 3519 89337318
Throat tightness 29.29 10.26 585 1287025 28899 89311938
Anosognosia 29.27 10.26 7 1287603 3515 89337322
Hepatitis B reactivation 29.15 10.26 10 1287600 3964 89336873
Electric shock 29.11 10.26 71 1287539 1651 89339186
Foot operation 29.09 10.26 52 1287558 8949 89331888
Abdominal pain upper 29.04 10.26 5259 1282351 327415 89013422
Urine ketone body present 29.00 10.26 91 1287519 2461 89338376
Arthropathy 28.98 10.26 4665 1282945 361577 88979260
Dermatitis atopic 28.74 10.26 205 1287405 23267 89317570
Anion gap increased 28.66 10.26 84 1287526 2186 89338651
Gastrointestinal disorder 28.56 10.26 4112 1283498 252575 89088262
Body temperature fluctuation 28.55 10.26 84 1287526 2191 89338646
Temperature regulation disorder 28.54 10.26 325 1287285 14254 89326583
Red cell distribution width increased 28.52 10.26 282 1287328 11925 89328912
Lip oedema 28.43 10.26 136 1287474 4503 89336334
Urine analysis abnormal 28.41 10.26 148 1287462 5073 89335764
Cerebrovascular accident 28.05 10.26 1451 1286159 122082 89218755
Dyspnoea exertional 27.96 10.26 797 1286813 71491 89269346
Intracranial pressure increased 27.87 10.26 179 1287431 6632 89334205
Gallbladder injury 27.81 10.26 59 1287551 1247 89339590
Device breakage 27.77 10.26 104 1287506 13940 89326897
Endophthalmitis 27.76 10.26 16 1287594 4669 89336168
Gamma-glutamyltransferase increased 27.70 10.26 721 1286889 37231 89303606
Hyperprolactinaemia 27.58 10.26 22 1287588 5411 89335426
Lymphoproliferative disorder 27.55 10.26 13 1287597 4249 89336588
Complication of device removal 27.39 10.26 29 1287581 6226 89334611
Cytomegalovirus viraemia 27.15 10.26 41 1287569 7545 89333292
Product dose omission in error 27.13 10.26 175 1287435 20328 89320509
Body temperature decreased 26.91 10.26 482 1287128 23334 89317503
Unresponsive to stimuli 26.90 10.26 721 1286889 37400 89303437
Renal failure neonatal 26.86 10.26 23 1287587 188 89340649
Pulmonary hypertension 26.60 10.26 434 1287176 42089 89298748
Hypertensive crisis 26.60 10.26 146 1287464 17638 89323199
Obesity 26.55 10.26 1226 1286384 104281 89236556
Coronary artery disease 26.39 10.26 328 1287282 33295 89307542
Acute myeloid leukaemia 26.39 10.26 178 1287432 20462 89320375
Schizophrenia 26.35 10.26 326 1287284 14588 89326249
Hypocalcaemia 26.31 10.26 433 1287177 41935 89298902
Oral pruritus 26.29 10.26 97 1287513 2854 89337983
Sputum culture positive 26.21 10.26 81 1287529 2172 89338665
Metastases to lymph nodes 26.21 10.26 82 1287528 11607 89329230
Product administration error 26.16 10.26 524 1287086 25899 89314938
Cholestatic liver injury 26.00 10.26 115 1287495 3682 89337155
Graft versus host disease in gastrointestinal tract 25.98 10.26 15 1287595 4373 89336464
Ventricular tachycardia 25.97 10.26 225 1287385 24483 89316354
Angioedema 25.76 10.26 1148 1286462 63728 89277109
BK virus infection 25.75 10.26 16 1287594 4482 89336355
Cerebral haematoma 25.75 10.26 125 1287485 4164 89336673
Hepatic cirrhosis 25.59 10.26 693 1286917 62560 89278277
JC virus infection 25.56 10.26 4 1287606 2715 89338122
Osteonecrosis of jaw 25.50 10.26 396 1287214 38707 89302130
Pulmonary arterial hypertension 25.12 10.26 244 1287366 25943 89314894
Impaired quality of life 25.11 10.26 209 1287401 22935 89317902
Superinfection 25.02 10.26 99 1287511 3013 89337824
Polycystic ovaries 25.00 10.26 26 1287584 5628 89335209
Colorectal cancer 24.97 10.26 12 1287598 3881 89336956
Cognitive disorder 24.95 10.26 1216 1286394 68191 89272646
Liver transplant 24.85 10.26 81 1287529 2236 89338601
Adverse event 24.82 10.26 1389 1286221 116029 89224808
Device deployment issue 24.76 10.26 20 1287590 4889 89335948
Hypoprothrombinaemia 24.70 10.26 30 1287580 385 89340452
Brain stem glioma 24.69 10.26 21 1287589 170 89340667
Polyneuropathy 24.63 10.26 167 1287443 19174 89321663
Granuloma 24.58 10.26 31 1287579 6154 89334683
Infusion site bruising 24.53 10.26 125 1287485 4247 89336590
Prothrombin level decreased 24.49 10.26 39 1287571 655 89340182
Anaphylactic reaction 24.45 10.26 1498 1286112 86026 89254811
Ascites 24.31 10.26 505 1287105 47235 89293602
Fear of injection 24.24 10.26 53 1287557 8462 89332375
Postnatal growth restriction 24.16 10.26 15 1287595 69 89340768
Injection site discolouration 24.14 10.26 61 1287549 9259 89331578
Gastrooesophageal reflux disease 24.12 10.26 2034 1285576 164303 89176534
Systemic candida 24.04 10.26 21 1287589 4938 89335899
Gait disturbance 24.02 10.26 3288 1284322 257208 89083629
Drug reaction with eosinophilia and systemic symptoms 23.99 10.26 786 1286824 41972 89298865
Bacterial test 23.91 10.26 51 1287559 1082 89339755
Food allergy 23.82 10.26 501 1287109 24977 89315860
Hyperthermia 23.78 10.26 238 1287372 10097 89330740
Asthma 23.72 10.26 3045 1284565 239115 89101722
Incorrect drug administration rate 23.72 10.26 141 1287469 5082 89335755
Muscle spasms 23.62 10.26 3176 1284434 248707 89092130
Epstein-Barr virus infection 23.59 10.26 72 1287538 10272 89330565
Incorrect dose administered by device 23.59 10.26 28 1287582 5709 89335128
Product adhesion issue 23.48 10.26 23 1287587 5119 89335718
Dissociation 23.36 10.26 37 1287573 6678 89334159
Feeling abnormal 23.36 10.26 2051 1285559 165184 89175653
Epilepsy 23.23 10.26 943 1286667 81263 89259574
Pancytopenia 23.22 10.26 1435 1286175 118828 89222009
Anti-neutrophil cytoplasmic antibody positive vasculitis 23.14 10.26 14 1287596 3979 89336858
Decreased appetite 23.13 10.26 4861 1282749 371679 88969158
Cardiomyopathy 23.06 10.26 180 1287430 20026 89320811
Vasoplegia syndrome 23.01 10.26 90 1287520 2724 89338113
Joint stiffness 22.96 10.26 891 1286719 77151 89263686
Chronic kidney disease 22.96 10.26 540 1287070 49651 89291186
Hepatic enzyme increased 22.88 10.26 5616 1281994 355120 88985717
Eye irritation 22.87 10.26 342 1287268 33636 89307201
Drug abuser 22.79 10.26 87 1287523 2603 89338234
Blood glucose increased 22.73 10.26 1113 1286497 94133 89246704
Constipation 22.72 10.26 4416 1283194 275979 89064858
Vital capacity decreased 22.67 10.26 67 1287543 1752 89339085
Polyomavirus-associated nephropathy 22.66 10.26 4 1287606 2486 89338351
Bone erosion 22.47 10.26 577 1287033 52444 89288393
Galactorrhoea 22.39 10.26 20 1287590 4652 89336185
Immune reconstitution inflammatory syndrome 22.28 10.26 41 1287569 6978 89333859
Balance disorder 22.22 10.26 1634 1285976 95446 89245391
Pulmonary fibrosis 22.13 10.26 1275 1286335 106228 89234609
Intentional product use issue 22.06 10.26 3457 1284153 213435 89127402
Hypomania 22.00 10.26 208 1287402 8689 89332148
Platelet count decreased 21.84 10.26 1662 1285948 135307 89205530
Bradycardia 21.76 10.26 1426 1286184 82421 89258416
Device leakage 21.76 10.26 71 1287539 9920 89330917
Joint dislocation 21.71 10.26 475 1287135 44107 89296730
Asphyxia 21.71 10.26 174 1287436 6929 89333908
Pregnancy with contraceptive device 21.62 10.26 24 1287586 5042 89335795
Drug eruption 21.62 10.26 363 1287247 35044 89305793
C-reactive protein increased 21.60 10.26 2251 1285359 179138 89161699
Adverse drug reaction 21.58 10.26 1398 1286212 115303 89225534
Biliary sepsis 21.52 10.26 45 1287565 941 89339896
Substance abuse 21.46 10.26 141 1287469 5265 89335572
Visual impairment 21.45 10.26 1604 1286006 130761 89210076
Cell death 21.28 10.26 93 1287517 2962 89337875
Culture urine positive 21.21 10.26 109 1287501 3716 89337121
Accidental poisoning 21.17 10.26 44 1287566 916 89339921
Lethargy 21.01 10.26 1098 1286512 62041 89278796
Osmolar gap 20.99 10.26 15 1287595 91 89340746
Stress cardiomyopathy 20.88 10.26 108 1287502 13247 89327590
Treatment noncompliance 20.59 10.26 568 1287042 51159 89289678
Wheezing 20.56 10.26 3017 1284593 235063 89105774
Glycosylated haemoglobin increased 20.50 10.26 133 1287477 15429 89325408
Accidental exposure to product by child 20.48 10.26 53 1287557 1280 89339557
Femur fracture 20.47 10.26 498 1287112 45584 89295253
Bezoar 20.41 10.26 85 1287525 2649 89338188
Abortion induced 20.41 10.26 93 1287517 11795 89329042
Congenital pulmonary hypertension 20.28 10.26 16 1287594 115 89340722
Forced expiratory volume decreased 20.21 10.26 32 1287578 5776 89335061
Adrenal insufficiency 20.20 10.26 301 1287309 29620 89311217
Nephropathy toxic 20.18 10.26 102 1287508 12586 89328251
Prescribed underdose 20.04 10.26 866 1286744 74153 89266684
Glutathione decreased 19.98 10.26 10 1287600 27 89340810
Anticipatory anxiety 19.96 10.26 50 1287560 1183 89339654
Hyperglycaemia 19.95 10.26 561 1287049 50409 89290428
Human herpesvirus 6 infection 19.94 10.26 12 1287598 3420 89337417
Graft versus host disease 19.80 10.26 55 1287555 8089 89332748
Haematochezia 19.70 10.26 815 1286795 70098 89270739
Nocardiosis 19.68 10.26 6 1287604 2564 89338273
Toxic anterior segment syndrome 19.65 10.26 4 1287606 2246 89338591
Loss of employment 19.48 10.26 9 1287601 2978 89337859
Blood pH decreased 19.47 10.26 80 1287530 2478 89338359
Breast cancer recurrent 19.45 10.26 30 1287580 5473 89335364
Hyperbilirubinaemia 19.44 10.26 292 1287318 13644 89327193
Administration site swelling 19.44 10.26 56 1287554 1443 89339394
Paraesthesia ear 19.42 10.26 28 1287582 429 89340408
Acute myeloid leukaemia recurrent 19.40 10.26 3 1287607 2054 89338783
Bacterial test positive 19.35 10.26 140 1287470 5399 89335438
Right ventricular failure 19.26 10.26 177 1287433 19028 89321809
Feeling cold 19.25 10.26 519 1287091 26946 89313891
Myopathy 19.12 10.26 113 1287497 13405 89327432
Macular oedema 19.10 10.26 25 1287585 4884 89335953
SJS-TEN overlap 19.07 10.26 46 1287564 1062 89339775
Liver function test abnormal 18.95 10.26 894 1286716 49951 89290886
Carpal tunnel syndrome 18.94 10.26 233 1287377 23695 89317142
Blood immunoglobulin E increased 18.84 10.26 21 1287589 4404 89336433
Hyperleukocytosis 18.80 10.26 40 1287570 847 89339990
Biliary dyskinesia 18.78 10.26 80 1287530 2519 89338318
Breast cancer stage III 18.77 10.26 994 1286616 83453 89257384
Drug screen positive 18.75 10.26 104 1287506 3653 89337184
Coagulation factor X level decreased 18.72 10.26 12 1287598 59 89340778
Dizziness 18.68 10.26 7821 1279789 581463 88759374
Weight fluctuation 18.68 10.26 389 1287221 19360 89321477
Liver injury 18.55 10.26 2729 1284881 167838 89172999
Prothrombin level increased 18.49 10.26 23 1287587 303 89340534
Pancreatitis acute 18.45 10.26 592 1287018 31523 89309314
Abnormal dreams 18.19 10.26 90 1287520 11167 89329670
Injury associated with device 18.13 10.26 22 1287588 4442 89336395
Osteoporosis 18.08 10.26 1155 1286455 95376 89245461
Bacterial disease carrier 18.04 10.26 63 1287547 1803 89339034
Self-medication 18.02 10.26 92 1287518 3128 89337709
Red blood cell sedimentation rate increased 18.02 10.26 974 1286636 81621 89259216
Local anaesthetic systemic toxicity 17.98 10.26 14 1287596 3486 89337351
Impaired healing 17.90 10.26 3678 1283932 230521 89110316
Needle issue 17.90 10.26 120 1287490 13814 89327023
Skin burning sensation 17.87 10.26 185 1287425 19426 89321411
Specific gravity urine increased 17.86 10.26 20 1287590 234 89340603
Emotional distress 17.84 10.26 663 1286947 35999 89304838
Catatonia 17.82 10.26 37 1287573 6019 89334818
Cerebral infarction 17.80 10.26 268 1287342 26328 89314509
Ankle arthroplasty 17.75 10.26 9 1287601 2822 89338015
Nitrite urine present 17.72 10.26 44 1287566 1035 89339802
Cardiac disorder 17.69 10.26 645 1286965 56227 89284610
Arthritis 17.61 10.26 2094 1285516 165221 89175616
Peptic ulcer haemorrhage 17.59 10.26 45 1287565 1079 89339758
Nephrotic syndrome 17.52 10.26 50 1287560 7289 89333548
Reversible airways obstruction 17.51 10.26 65 1287545 1918 89338919
Blood creatinine decreased 17.47 10.26 155 1287455 6360 89334477
Thrombosis 17.47 10.26 856 1286754 72395 89268442
C-reactive protein abnormal 17.47 10.26 1565 1286045 125864 89214973
Cryopyrin associated periodic syndrome 17.46 10.26 30 1287580 538 89340299
Metastases to central nervous system 17.45 10.26 162 1287448 17380 89323457
Osteoarthritis 17.39 10.26 2476 1285134 193254 89147583
Diffuse axonal injury 17.32 10.26 13 1287597 86 89340751
Vitamin K deficiency 17.30 10.26 28 1287582 477 89340360
Infusion site discomfort 17.29 10.26 61 1287549 1755 89339082
Oropharyngeal discomfort 17.26 10.26 177 1287433 7558 89333279
Coagulation factor V level increased 17.22 10.26 6 1287604 3 89340834
Cyanosis neonatal 17.18 10.26 26 1287584 417 89340420
Sexual dysfunction 17.16 10.26 26 1287584 4778 89336059
Face oedema 17.02 10.26 443 1287167 22875 89317962
Hallucination 16.98 10.26 1121 1286489 64838 89275999
Impaired work ability 16.93 10.26 184 1287426 19142 89321695
Mycobacterium avium complex infection 16.85 10.26 20 1287590 4078 89336759
Gallbladder disorder 16.79 10.26 384 1287226 19419 89321418
Infusion site haemorrhage 16.78 10.26 133 1287477 5278 89335559
Hypersensitivity 16.72 10.26 6929 1280681 447748 88893089
Hyponatraemia 16.66 10.26 2154 1285456 131384 89209453
Open globe injury 16.62 10.26 10 1287600 43 89340794
Sphincter of Oddi dysfunction 16.61 10.26 26 1287584 430 89340407
Respiratory disorder 16.58 10.26 1101 1286509 63715 89277122
Intentional dose omission 16.51 10.26 167 1287443 17616 89323221
Device use issue 16.50 10.26 17 1287593 3696 89337141
Knee arthroplasty 16.50 10.26 990 1286620 82192 89258645
Incorrect route of product administration 16.47 10.26 571 1287039 50055 89290782
Coma hepatic 16.45 10.26 32 1287578 634 89340203
Migraine with aura 16.43 10.26 90 1287520 3146 89337691
Truncus coeliacus thrombosis 16.42 10.26 7 1287603 11 89340826
Hyperlipidaemia 16.36 10.26 228 1287382 22688 89318149
Analgesic drug level therapeutic 16.34 10.26 5 1287605 0 89340837
Specific gravity urine abnormal 16.15 10.26 12 1287598 78 89340759
Agranulocytosis 16.08 10.26 629 1286981 34373 89306464
Amenorrhoea 16.05 10.26 99 1287511 11623 89329214
Bone pain 16.05 10.26 718 1286892 61265 89279572
Granulocytopenia 16.04 10.26 43 1287567 6398 89334439
Cystitis haemorrhagic 15.95 10.26 34 1287576 5479 89335358
Eczema 15.91 10.26 602 1287008 52268 89288569
Dyskinesia 15.91 10.26 396 1287214 36138 89304699
Dermatitis 15.89 10.26 221 1287389 21999 89318838
Kidney transplant rejection 15.75 10.26 28 1287582 4829 89336008
Bronchopulmonary aspergillosis 15.75 10.26 96 1287514 11302 89329535
Acute haemorrhagic oedema of infancy 15.71 10.26 7 1287603 13 89340824
Haemorrhage 15.70 10.26 815 1286795 68554 89272283
Transient ischaemic attack 15.70 10.26 480 1287130 42696 89298141
Gallbladder adenocarcinoma 15.70 10.26 13 1287597 101 89340736
Pneumonia 15.69 10.26 8539 1279071 629520 88711317
Metabolic disorder 15.65 10.26 54 1287556 7416 89333421
Pain 15.59 10.26 13500 1274110 982841 88357996
Mania 15.57 10.26 127 1287483 13997 89326840
Foetal heart rate abnormal 15.56 10.26 39 1287571 923 89339914
Physical deconditioning 15.54 10.26 68 1287542 2167 89338670
Taste disorder 15.52 10.26 715 1286895 60831 89280006
Tuberculin test positive 15.51 10.26 18 1287592 3707 89337130
Toxicologic test abnormal 15.51 10.26 33 1287577 699 89340138
Haemolysis 15.46 10.26 187 1287423 8323 89332514
Blepharospasm 15.45 10.26 637 1286973 54808 89286029
Shoulder arthroplasty 15.42 10.26 22 1287588 4144 89336693
Cystic fibrosis 15.40 10.26 20 1287590 3921 89336916
Dysphoria 15.39 10.26 41 1287569 6113 89334724
Staphylococcal infection 15.37 10.26 548 1287062 47891 89292946
Gingival hypertrophy 15.35 10.26 6 1287604 2194 89338643
Eosinophil percentage increased 15.26 10.26 40 1287570 974 89339863
Pancreatic fibrosis 15.24 10.26 12 1287598 86 89340751
Blood phosphorus decreased 15.21 10.26 123 1287487 4911 89335926
Injection site haematoma 15.21 10.26 49 1287561 6873 89333964
Nodule 15.20 10.26 277 1287333 26409 89314428
Rash erythematous 15.10 10.26 1097 1286513 64007 89276830
Adulterated product 15.10 10.26 23 1287587 371 89340466
Paraesthesia 15.03 10.26 3235 1284375 247091 89093746
Administration site pain 15.01 10.26 44 1287566 1145 89339692
Bladder cancer 15.00 10.26 38 1287572 5763 89335074
Pulmonary toxicity 14.96 10.26 99 1287511 11432 89329405
Product tampering 14.96 10.26 25 1287585 438 89340399
Syncope 14.90 10.26 1653 1285957 131010 89209827
Blood creatine increased 14.87 10.26 158 1287452 6809 89334028
Brain compression 14.83 10.26 27 1287583 508 89340329
Agitation 14.79 10.26 1126 1286484 65972 89274865
Drug effective for unapproved indication 14.78 10.26 60 1287550 7858 89332979
Body tinea 14.76 10.26 6 1287604 2142 89338695
Acute myocardial infarction 14.70 10.26 380 1287230 34510 89306327
Hepatitis B 14.70 10.26 26 1287584 4493 89336344
Weight increased 14.67 10.26 6359 1281251 411568 88929269
Congenital tricuspid valve incompetence 14.64 10.26 14 1287596 134 89340703
Epstein-Barr virus associated lymphoproliferative disorder 14.57 10.26 10 1287600 2657 89338180
Sensitivity to weather change 14.56 10.26 71 1287539 8843 89331994
Nephrectomy 14.51 10.26 5 1287605 1976 89338861
Rash pruritic 14.50 10.26 989 1286621 81225 89259612
Prothrombin time ratio increased 14.48 10.26 13 1287597 114 89340723
Oedema peripheral 14.47 10.26 3344 1284266 254571 89086266
Respiratory alkalosis 14.34 10.26 91 1287519 3357 89337480
Laboratory test abnormal 14.33 10.26 469 1287141 41385 89299452
Administration site bruise 14.26 10.26 25 1287585 456 89340381
Kussmaul respiration 14.21 10.26 19 1287591 270 89340567
Haematoma muscle 14.19 10.26 58 1287552 1792 89339045
Leukocyturia 14.19 10.26 53 1287557 1569 89339268
Subacute cutaneous lupus erythematosus 14.18 10.26 18 1287592 3564 89337273
Venoocclusive liver disease 14.18 10.26 41 1287569 5952 89334885
Vaginal haemorrhage 14.15 10.26 337 1287273 30934 89309903
Cardiovascular disorder 14.12 10.26 123 1287487 13369 89327468
Myocardial fibrosis 14.08 10.26 37 1287573 902 89339935
Rebound effect 14.05 10.26 77 1287533 9307 89331530
Autonomic dysreflexia 14.05 10.26 22 1287588 364 89340473
Spleen congestion 14.02 10.26 12 1287598 98 89340739
Infusion site mass 14.02 10.26 65 1287545 2124 89338713
Allodynia 14.01 10.26 39 1287571 985 89339852
Renal disorder 13.99 10.26 420 1287190 37439 89303398
Exostosis 13.86 10.26 615 1286995 52519 89288318
Peptic ulcer perforation 13.83 10.26 24 1287586 434 89340403
Vitritis 13.83 10.26 3 1287607 1611 89339226
Glomerular filtration rate increased 13.81 10.26 62 1287548 1998 89338839
Breast cancer stage II 13.80 10.26 389 1287221 34945 89305892
Respiratory acidosis 13.71 10.26 176 1287434 7943 89332894
Amniotic cavity disorder 13.70 10.26 10 1287600 63 89340774
Stoma site cellulitis 13.70 10.26 10 1287600 63 89340774
Strongyloidiasis 13.68 10.26 3 1287607 1599 89339238
Monocyte percentage increased 13.66 10.26 43 1287567 1165 89339672
Uterine perforation 13.63 10.26 58 1287552 7496 89333341
Disability 13.61 10.26 458 1287152 40287 89300550
Caesarean section 13.56 10.26 184 1287426 18393 89322444
Feeling hot 13.55 10.26 1286 1286324 76722 89264115
Adrenergic syndrome 13.47 10.26 12 1287598 104 89340733
Hypotonic-hyporesponsive episode 13.47 10.26 7 1287603 21 89340816
Tenosynovitis 13.44 10.26 137 1287473 14430 89326407
Foetal arrhythmia 13.43 10.26 16 1287594 201 89340636
Akathisia 13.40 10.26 98 1287512 11061 89329776
Skin cancer 13.38 10.26 125 1287485 13394 89327443
Activated partial thromboplastin time prolonged 13.38 10.26 170 1287440 7655 89333182
Aspirin-exacerbated respiratory disease 13.36 10.26 30 1287580 660 89340177
Infusion site urticaria 13.34 10.26 54 1287556 1661 89339176
Blood folate decreased 13.32 10.26 53 1287557 1617 89339220
Substance use disorder 13.31 10.26 6 1287604 2014 89338823
Agonal respiration 13.30 10.26 15 1287595 177 89340660
Vulvar erosion 13.30 10.26 15 1287595 177 89340660
Fracture 13.26 10.26 227 1287383 21849 89318988
Accidental death 13.25 10.26 61 1287549 1987 89338850
Intestinal haemorrhage 13.23 10.26 27 1287583 4420 89336417
Neovascularisation 13.22 10.26 52 1287558 1578 89339259
Congestive hepatopathy 13.21 10.26 81 1287529 2952 89337885
Hyperprolinaemia 13.19 10.26 6 1287604 12 89340825
Skin ulcer 13.18 10.26 579 1287031 49496 89291341
Creatinine urine decreased 13.18 10.26 19 1287591 291 89340546
Arthrodesis 13.15 10.26 14 1287596 2998 89337839
Full blood count decreased 13.14 10.26 321 1287289 29368 89311469
Cells in urine 13.11 10.26 15 1287595 180 89340657
Suicidal ideation 13.10 10.26 888 1286722 72967 89267870
Eustachian tube patulous 13.07 10.26 4 1287606 0 89340837
Fibrin D dimer decreased 13.07 10.26 4 1287606 0 89340837
Type 2 diabetes mellitus 13.03 10.26 2618 1284992 200626 89140211
Vaccination site swelling 13.02 10.26 8 1287602 36 89340801
White coat hypertension 13.01 10.26 38 1287572 987 89339850
Gastric cancer 13.01 10.26 34 1287576 5102 89335735
Squamous cell carcinoma 12.97 10.26 87 1287523 10014 89330823
Scoliosis 12.96 10.26 188 1287422 8719 89332118
Hypoglycaemic coma 12.94 10.26 14 1287596 2976 89337861
Injection site irritation 12.93 10.26 43 1287567 5972 89334865
Anaphylactoid reaction 12.87 10.26 108 1287502 4360 89336477
Low density lipoprotein increased 12.86 10.26 65 1287545 8020 89332817
Tumour marker increased 12.83 10.26 41 1287569 5766 89335071
Neutropenic sepsis 12.82 10.26 343 1287267 17787 89323050
Pulmonary alveolar haemorrhage 12.81 10.26 43 1287567 5955 89334882
Frostbite 12.80 10.26 16 1287594 212 89340625
Dose calculation error 12.77 10.26 20 1287590 331 89340506
Ejection fraction abnormal 12.75 10.26 10 1287600 2481 89338356
Acute fatty liver of pregnancy 12.69 10.26 8 1287602 38 89340799
Coma scale abnormal 12.68 10.26 129 1287481 5497 89335340
Blood lactic acid increased 12.67 10.26 185 1287425 8593 89332244
Activated partial thromboplastin time abnormal 12.64 10.26 13 1287597 137 89340700
Coronary arterial stent insertion 12.63 10.26 13 1287597 2827 89338010
Osteomyelitis 12.62 10.26 300 1287310 27546 89313291
Injection site nodule 12.60 10.26 28 1287582 4445 89336392
Gallbladder hypofunction 12.60 10.26 24 1287586 468 89340369
Renal tubular necrosis 12.58 10.26 283 1287327 14272 89326565
Hip arthroplasty 12.58 10.26 922 1286688 75286 89265551
Fibromyalgia 12.54 10.26 2664 1284946 203605 89137232
Lymphoma 12.47 10.26 128 1287482 13463 89327374
Embedded device 12.46 10.26 26 1287584 4222 89336615
Vein collapse 12.44 10.26 40 1287570 1096 89339741
Renal cancer 12.43 10.26 43 1287567 5902 89334935
Infusion site nodule 12.42 10.26 53 1287557 1670 89339167
Lupus vasculitis 12.41 10.26 27 1287583 581 89340256
Catheterisation cardiac 12.40 10.26 33 1287577 4923 89335914
Injection site discomfort 12.40 10.26 43 1287567 5897 89334940
Cardiac steatosis 12.38 10.26 8 1287602 40 89340797
Alpha 1 microglobulin increased 12.38 10.26 8 1287602 40 89340797
Lip pruritus 12.37 10.26 45 1287565 1315 89339522
Intervertebral discitis 12.36 10.26 108 1287502 4412 89336425
Device defective 12.32 10.26 19 1287591 3467 89337370
Dysmorphism 12.30 10.26 11 1287599 2557 89338280
Limb mass 12.22 10.26 89 1287521 3439 89337398
Mediastinal abscess 12.20 10.26 7 1287603 27 89340810
White blood cells urine 12.19 10.26 23 1287587 445 89340392
Eosinophil count increased 12.16 10.26 257 1287353 12824 89328013
Histoplasmosis disseminated 12.12 10.26 9 1287601 2296 89338541
Hepatic cyst 12.12 10.26 50 1287560 6518 89334319
Stent placement 12.10 10.26 26 1287584 4177 89336660
Sinus tachycardia 12.09 10.26 508 1287102 28005 89312832
Clonus 12.09 10.26 130 1287480 5620 89335217
Atypical mycobacterial infection 12.09 10.26 4 1287606 1622 89339215
Neuroblastoma recurrent 12.05 10.26 14 1287596 171 89340666
Nail operation 12.04 10.26 6 1287604 1900 89338937
Continuous haemodiafiltration 12.01 10.26 35 1287575 908 89339929
Regurgitation 12.00 10.26 8 1287602 2158 89338679
Juvenile idiopathic arthritis 11.95 10.26 24 1287586 3953 89336884
Neonatal respiratory acidosis 11.95 10.26 17 1287593 257 89340580
Nutritional supplementation 11.94 10.26 8 1287602 43 89340794
Occupational exposure to product 11.93 10.26 11 1287599 2520 89338317
Epigastric discomfort 11.93 10.26 162 1287448 7406 89333431
Complications of transplanted kidney 11.88 10.26 14 1287596 2864 89337973
Bone lesion 11.88 10.26 49 1287561 6388 89334449
Congenital central hypoventilation syndrome 11.83 10.26 7 1287603 29 89340808
Drug provocation test 11.83 10.26 7 1287603 29 89340808
Skin exfoliation 11.80 10.26 818 1286792 67095 89273742
Alcohol use 11.75 10.26 52 1287558 1665 89339172
Lyme disease 11.75 10.26 27 1287583 4235 89336602
Eye pruritus 11.74 10.26 318 1287292 28709 89312128
Rhinorrhoea 11.72 10.26 1430 1286180 86886 89253951
Hypertriglyceridaemia 11.67 10.26 65 1287545 7824 89333013
Altered state of consciousness 11.66 10.26 554 1287056 30978 89309859
Infusion site irritation 11.66 10.26 44 1287566 1309 89339528
Osmolar gap abnormal 11.65 10.26 7 1287603 30 89340807
Disseminated tuberculosis 11.65 10.26 18 1287592 3281 89337556
Lip infection 11.63 10.26 12 1287598 127 89340710
Impulsive behaviour 11.62 10.26 5 1287605 1725 89339112
Tuberculosis 11.59 10.26 118 1287492 12431 89328406
Inadequate analgesia 11.56 10.26 82 1287528 3142 89337695
Therapy change 11.54 10.26 70 1287540 8252 89332585
Atelectasis 11.54 10.26 440 1287170 23969 89316868
General physical health deterioration 11.51 10.26 4709 1282901 350406 88990431
Thyroid cancer 11.49 10.26 48 1287562 6236 89334601
Pleural fibrosis 11.49 10.26 89 1287521 3507 89337330
SARS-CoV-2 test positive 11.46 10.26 222 1287388 10906 89329931
Antidepressant drug level above therapeutic 11.45 10.26 23 1287587 467 89340370
Urinary casts 11.42 10.26 31 1287579 771 89340066
Inappropriate schedule of product administration 11.39 10.26 2354 1285256 147579 89193258
Transplant failure 11.28 10.26 7 1287603 1962 89338875
Cerebral toxoplasmosis 11.28 10.26 3 1287607 1402 89339435
Neoplasm 11.27 10.26 77 1287533 8826 89332011
Arrhythmia neonatal 11.27 10.26 9 1287601 66 89340771
Neuropathy, ataxia, retinitis pigmentosa syndrome 11.26 10.26 8 1287602 48 89340789
Focal dyscognitive seizures 11.25 10.26 17 1287593 3127 89337710
Bladder sphincter atony 11.23 10.26 15 1287595 213 89340624
Non-pitting oedema 11.21 10.26 12 1287598 133 89340704
COVID-19 11.19 10.26 2634 1284976 166209 89174628
Leukocytosis 11.15 10.26 543 1287067 30447 89310390
Premature rupture of membranes 11.09 10.26 41 1287569 5517 89335320
Peritonitis bacterial 11.09 10.26 37 1287573 5134 89335703
Immunosuppressant drug level increased 11.09 10.26 32 1287578 4648 89336189
Spinal meningioma benign 11.06 10.26 11 1287599 111 89340726
Secretion discharge 11.05 10.26 159 1287451 15737 89325100
Cholesterosis 11.04 10.26 22 1287588 444 89340393
Urobilinogen urine increased 11.04 10.26 17 1287593 277 89340560
Human chorionic gonadotropin increased 11.03 10.26 7 1287603 1939 89338898
Cholangitis acute 11.01 10.26 26 1287584 592 89340245
Allergy to immunoglobulin therapy 11.00 10.26 14 1287596 189 89340648
Stomatitis 11.00 10.26 4199 1283411 270499 89070338
Harlequin syndrome 10.98 10.26 15 1287595 218 89340619
Post procedural pulmonary embolism 10.98 10.26 15 1287595 218 89340619
Infection reactivation 10.97 10.26 7 1287603 1933 89338904
Soft tissue disorder 10.96 10.26 101 1287509 4189 89336648
Splenic vein thrombosis 10.94 10.26 21 1287589 412 89340425
Tongue disorder 10.93 10.26 100 1287510 10760 89330077
Thymus disorder 10.90 10.26 18 1287592 312 89340525
Blood prolactin increased 10.89 10.26 22 1287588 3615 89337222
Base excess 10.89 10.26 8 1287602 51 89340786
Catheter site bruise 10.87 10.26 25 1287585 559 89340278
Cholecystitis acute 10.87 10.26 191 1287419 9213 89331624
Infectious thyroiditis 10.86 10.26 9 1287601 70 89340767
Hyperhidrosis 10.85 10.26 2145 1285465 134160 89206677
Pregnancy 10.84 10.26 747 1286863 61300 89279537
pH urine increased 10.81 10.26 20 1287590 381 89340456
Left ventricular dysfunction 10.81 10.26 145 1287465 14524 89326313
Contusion 10.80 10.26 3850 1283760 247366 89093471
Herpes zoster 10.79 10.26 1178 1286432 93466 89247371
Pulmonary tuberculosis 10.78 10.26 34 1287576 4800 89336037
Gallbladder cholesterolosis 10.77 10.26 30 1287580 758 89340079
Concomitant disease aggravated 10.76 10.26 108 1287502 11410 89329427
Infusion site reaction 10.72 10.26 198 1287412 18841 89321996
Toxoplasmosis 10.71 10.26 6 1287604 1779 89339058
Spondyloarthropathy 10.71 10.26 40 1287570 1184 89339653
Growth retardation 10.69 10.26 6 1287604 1777 89339060
Tonsillar inflammation 10.69 10.26 11 1287599 116 89340721
Presbyacusis 10.69 10.26 77 1287533 2965 89337872
Bronchospasm 10.69 10.26 377 1287233 20332 89320505
Sinus operation 10.68 10.26 76 1287534 2915 89337922
Breast cancer stage IV 10.67 10.26 8 1287602 2030 89338807
Gait inability 10.65 10.26 1874 1285736 144582 89196255
Pineal gland cyst 10.63 10.26 14 1287596 196 89340641
Retinal haemorrhage 10.56 10.26 44 1287566 5720 89335117
Post cholecystectomy syndrome 10.55 10.26 32 1287578 849 89339988
Postmortem blood drug level increased 10.55 10.26 28 1287582 687 89340150
Viral haemorrhagic cystitis 10.54 10.26 4 1287606 1489 89339348
Torsade de pointes 10.50 10.26 152 1287458 15030 89325807
Lupus hepatitis 10.48 10.26 6 1287604 23 89340814
Metastases to skin 10.45 10.26 9 1287601 2131 89338706
Cardiogenic shock 10.44 10.26 266 1287344 24202 89316635
Acute lymphocytic leukaemia recurrent 10.44 10.26 14 1287596 2707 89338130
Duodenal ulcer perforation 10.42 10.26 3403 1284207 217885 89122952
Clostridium difficile infection 10.40 10.26 415 1287195 35830 89305007
Wound infection 10.40 10.26 1338 1286272 105064 89235773
Neurone-specific enolase increased 10.39 10.26 5 1287605 12 89340825
Neoplasm recurrence 10.38 10.26 19 1287591 3240 89337597
Corticosteroid binding globulin increased 10.36 10.26 4 1287606 4 89340833
Manufacturing production issue 10.36 10.26 4 1287606 4 89340833
Transfusion-related acute lung injury 10.35 10.26 13 1287597 173 89340664
Fear of disease 10.33 10.26 45 1287565 1431 89339406
Catheter management 10.31 10.26 17 1287593 3019 89337818
Fungal rhinitis 10.29 10.26 6 1287604 24 89340813
Strawberry tongue 10.29 10.26 6 1287604 24 89340813
Restrictive pulmonary disease 10.29 10.26 11 1287599 2351 89338486
Sinus rhythm 10.28 10.26 43 1287567 1343 89339494

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1756.90 11.72 6390 505661 222746 41886538
Intentional overdose 1001.42 11.72 2028 510023 49428 42059856
Completed suicide 869.92 11.72 2843 509208 93622 42015662
Drug ineffective 867.53 11.72 4268 507783 625929 41483355
Exposure to toxic agent 856.93 11.72 607 511444 4397 42104887
Acute hepatic failure 775.69 11.72 991 511060 16082 42093202
Overdose 716.58 11.72 2830 509221 102434 42006850
Infusion related reaction 630.82 11.72 1882 510169 58924 42050360
Analgesic drug level increased 484.87 11.72 246 511805 862 42108422
Hepatocellular injury 407.68 11.72 888 511163 22790 42086494
Suicide attempt 359.33 11.72 1295 510756 44805 42064479
Poisoning deliberate 352.52 11.72 517 511534 9617 42099667
Blood pressure fluctuation 278.05 11.72 832 511219 26076 42083208
Hepatic cytolysis 272.65 11.72 825 511226 26019 42083265
Intentional product misuse 265.71 11.72 1455 510596 60445 42048839
Drug resistance 237.99 11.72 59 511992 34189 42075095
Myelosuppression 228.12 11.72 100 511951 40361 42068923
Treatment failure 203.85 11.72 272 511779 62352 42046932
Liver injury 190.24 11.72 584 511467 18564 42090720
Therapeutic product effect incomplete 179.68 11.72 363 511688 70576 42038708
Heart rate decreased 179.00 11.72 891 511160 35641 42073643
Chills 177.37 11.72 1819 510232 92247 42017037
Cholestasis 177.05 11.72 824 511227 32055 42077229
Metabolic acidosis 176.95 11.72 1148 510903 50710 42058574
Cytokine release syndrome 170.90 11.72 1016 511035 43511 42065773
Hepatitis acute 168.80 11.72 349 511702 8626 42100658
Accidental overdose 160.72 11.72 721 511330 27609 42081675
Vomiting 156.45 11.72 4571 507480 285152 41824132
Product dose omission issue 153.56 11.72 1154 510897 153211 41956073
Pyroglutamic acidosis 150.30 11.72 102 511949 683 42108601
Myocardial infarction 134.04 11.72 905 511146 123104 41986180
Toxic epidermal necrolysis 130.73 11.72 652 511399 26098 42083186
Disease progression 128.99 11.72 1104 510947 142552 41966732
Fixed eruption 126.79 11.72 152 511899 2302 42106982
Blood pressure diastolic abnormal 124.42 11.72 246 511805 5882 42103402
Injection site pain 118.27 11.72 331 511720 57467 42051817
Urticaria 118.03 11.72 1385 510666 72651 42036633
Hepatitis 117.27 11.72 642 511409 26658 42082626
Blood pressure increased 115.95 11.72 1794 510257 100134 42009150
Coagulopathy 113.89 11.72 548 511503 21614 42087670
Drug ineffective for unapproved indication 112.00 11.72 242 511809 45921 42063363
Hepatitis fulminant 111.65 11.72 208 511843 4751 42104533
Cardiac failure congestive 110.22 11.72 591 511460 85011 42024273
Oxygen saturation decreased 108.89 11.72 1223 510828 63464 42045820
Blood pressure systolic increased 108.47 11.72 640 511411 27328 42081956
Mixed liver injury 104.94 11.72 191 511860 4283 42105001
Blood pressure systolic abnormal 101.66 11.72 213 511838 5315 42103969
Cardiac failure 101.43 11.72 809 511242 106047 42003237
Coma 100.58 11.72 1035 511016 52519 42056765
Sleep disorder due to a general medical condition 100.18 11.72 42 512009 17411 42091873
Medication error 95.36 11.72 704 511347 32450 42076834
Anion gap 92.17 11.72 78 511973 755 42108529
Suspected suicide 91.71 11.72 219 511832 5980 42103304
Anaphylactic reaction 90.48 11.72 847 511204 41896 42067388
Prothrombin time shortened 89.71 11.72 103 511948 1486 42107798
Therapy partial responder 87.92 11.72 67 511984 19954 42089330
Suspected suicide attempt 86.06 11.72 55 511996 328 42108956
Somnolence 85.98 11.72 2262 509789 138843 41970441
Renal impairment 85.64 11.72 878 511173 109350 41999934
Prothrombin time ratio decreased 81.82 11.72 63 511988 526 42108758
Product use in unapproved indication 77.35 11.72 1658 510393 182798 41926486
Hospitalisation 75.58 11.72 552 511499 73778 42035506
Therapy non-responder 75.15 11.72 357 511694 53002 42056282
Haematotoxicity 74.25 11.72 20 512031 10965 42098319
Obstructive airways disorder 73.20 11.72 115 511936 24644 42084640
Drug interaction 72.54 11.72 2552 509499 264447 41844837
Intercepted product preparation error 72.38 11.72 4 512047 7385 42101899
Multiple-drug resistance 71.61 11.72 4 512047 7318 42101966
Abdominal pain 70.76 11.72 2879 509172 187592 41921692
Hepatitis cholestatic 69.01 11.72 267 511784 9557 42099727
Pathogen resistance 66.61 11.72 27 512024 11423 42097861
BK virus infection 65.32 11.72 13 512038 8771 42100513
Methaemoglobinaemia 64.87 11.72 184 511867 5590 42103694
Wrong technique in product usage process 64.38 11.72 278 511773 42357 42066927
Full blood count abnormal 64.19 11.72 167 511884 29709 42079575
Eosinophilic granulomatosis with polyangiitis 63.78 11.72 13 512038 8625 42100659
Post transplant lymphoproliferative disorder 62.79 11.72 16 512035 9104 42100180
Diarrhoea 62.48 11.72 4730 507321 456119 41653165
Ductus arteriosus premature closure 61.30 11.72 38 512013 213 42109071
Cytomegalovirus infection 60.32 11.72 193 511858 32113 42077171
Pulmonary alveolar haemorrhage 59.60 11.72 54 511997 14762 42094522
Pulmonary vasculitis 59.55 11.72 4 512047 6262 42103022
Prostate cancer 58.67 11.72 306 511745 44337 42064947
Hepatic failure 58.60 11.72 708 511343 37392 42071892
Hepatotoxicity 58.51 11.72 509 511542 24658 42084626
Graft versus host disease 58.38 11.72 42 512009 12883 42096401
Blood pressure diastolic increased 57.80 11.72 189 511862 6216 42103068
Stevens-Johnson syndrome 56.58 11.72 458 511593 21720 42087564
Immune reconstitution inflammatory syndrome 55.70 11.72 26 512025 10117 42099167
Throat irritation 55.60 11.72 306 511745 12730 42096554
Hepatic necrosis 55.49 11.72 136 511915 3777 42105507
Depressed level of consciousness 55.14 11.72 846 511205 47124 42062160
Loss of personal independence in daily activities 54.54 11.72 362 511689 49454 42059830
Drug-induced liver injury 54.48 11.72 701 511350 37572 42071712
Transaminases increased 54.07 11.72 619 511432 32266 42077018
Bladder cancer 53.48 11.72 76 511975 16971 42092313
Body temperature increased 53.34 11.72 423 511628 19935 42089349
Respiratory depression 53.31 11.72 399 511652 18469 42090815
Progressive multifocal leukoencephalopathy 52.74 11.72 37 512014 11499 42097785
Syringe issue 51.72 11.72 19 512032 8537 42100747
Body temperature decreased 51.55 11.72 323 511728 14090 42095194
Alanine aminotransferase increased 51.44 11.72 1409 510642 86997 42022287
Tachycardia 51.39 11.72 1584 510467 99503 42009781
Neuritis 51.16 11.72 7 512044 6213 42103071
Cardio-respiratory arrest 51.07 11.72 989 511062 57647 42051637
Inspiratory capacity decreased 50.74 11.72 111 511940 2856 42106428
Postnatal growth restriction 50.68 11.72 31 512020 169 42109115
International normalised ratio increased 50.66 11.72 837 511214 47331 42061953
Infusion site extravasation 50.60 11.72 163 511888 5318 42103966
Febrile neutropenia 49.89 11.72 2718 509333 182985 41926299
Poisoning 49.86 11.72 325 511726 14374 42094910
Spirometry abnormal 49.75 11.72 3 512048 5143 42104141
Device leakage 49.71 11.72 31 512020 10254 42099030
Therapeutic response decreased 49.02 11.72 253 511798 36759 42072525
Pyrexia 47.79 11.72 5419 506632 388623 41720661
Cell death 47.57 11.72 108 511943 2851 42106433
Therapeutic product effect decreased 47.26 11.72 276 511775 38874 42070410
Treatment noncompliance 46.86 11.72 263 511788 37409 42071875
Mycotic allergy 46.84 11.72 3 512048 4888 42104396
Chronic graft versus host disease 46.77 11.72 8 512043 6017 42103267
Pyroglutamate increased 46.64 11.72 35 512016 280 42109004
Contraindicated product administered 46.47 11.72 152 511899 25120 42084164
Hypotension 45.98 11.72 3642 508409 253989 41855295
Oesophageal carcinoma 45.80 11.72 30 512021 9666 42099618
Mite allergy 45.75 11.72 4 512047 5042 42104242
Acute graft versus host disease in skin 45.71 11.72 16 512035 7408 42101876
Venoocclusive liver disease 44.57 11.72 35 512016 10267 42099017
Off label use 44.45 11.72 6864 505187 631471 41477813
Dust allergy 43.85 11.72 6 512045 5326 42103958
Rebound effect 43.58 11.72 17 512034 7362 42101922
C-reactive protein abnormal 43.28 11.72 29 512022 9232 42100052
Inadequate analgesia 43.11 11.72 109 511942 3088 42106196
Flushing 42.92 11.72 654 511397 36374 42072910
Coronary artery disease 42.89 11.72 425 511626 53295 42055989
Cerebral infarction 42.45 11.72 211 511840 30958 42078326
Nocardiosis 42.31 11.72 6 512045 5184 42104100
Rash maculo-papular 42.18 11.72 659 511392 36844 42072440
Aspergillus infection 41.84 11.72 79 511972 15758 42093526
Pharyngeal paraesthesia 41.64 11.72 53 511998 856 42108428
Cholestatic liver injury 41.48 11.72 118 511933 3591 42105693
Back pain 40.85 11.72 2089 509962 139687 41969597
Blood pressure diastolic decreased 40.60 11.72 238 511813 10137 42099147
Acute generalised exanthematous pustulosis 40.23 11.72 207 511844 8388 42100896
Generalised bullous fixed drug eruption 39.78 11.72 37 512014 410 42108874
Forced expiratory volume decreased 39.73 11.72 21 512030 7609 42101675
Intentional product use issue 39.31 11.72 1136 510915 70697 42038587
Bronchopulmonary aspergillosis 39.19 11.72 112 511939 19317 42089967
Condition aggravated 38.49 11.72 2656 509395 258098 41851186
Death 38.13 11.72 5020 507031 466165 41643119
Confusional state 37.76 11.72 2415 509636 165182 41944102
Drug dose omission by device 37.43 11.72 12 512039 5874 42103410
Heart rate increased 37.23 11.72 870 511181 52385 42056899
Aspartate aminotransferase increased 37.07 11.72 1201 510850 75962 42033322
Hyperthermia 36.72 11.72 268 511783 12306 42096978
Transplant rejection 36.59 11.72 67 511984 13521 42095763
Infusion site pain 36.57 11.72 145 511906 5250 42104034
Myopathy 36.04 11.72 69 511982 13692 42095592
Oedematous pancreatitis 35.86 11.72 45 512006 716 42108568
Poor venous access 35.59 11.72 177 511874 7075 42102209
Acute graft versus host disease 35.42 11.72 28 512023 8187 42101097
Lymphocyte count abnormal 35.35 11.72 80 511971 2107 42107177
Asthma 35.29 11.72 531 511520 61783 42047501
Psoriatic arthropathy 34.59 11.72 168 511883 24799 42084485
Glycosylated haemoglobin increased 34.56 11.72 64 511987 12860 42096424
Respiratory symptom 34.36 11.72 50 512001 11056 42098228
Conjunctivitis allergic 34.28 11.72 14 512037 5897 42103387
Endophthalmitis 34.16 11.72 6 512045 4427 42104857
Virologic failure 34.05 11.72 4 512047 3990 42105294
Acute myocardial infarction 33.85 11.72 493 511558 57672 42051612
Rhinalgia 33.85 11.72 71 511980 1773 42107511
Therapy interrupted 33.02 11.72 146 511905 22104 42087180
Cardiac failure chronic 32.99 11.72 40 512011 9561 42099723
Diabetes mellitus 32.67 11.72 516 511535 59571 42049713
Infusion site pruritus 32.64 11.72 54 511997 1119 42108165
Psoriasis 32.64 11.72 400 511651 48204 42061080
Blood glucose increased 32.44 11.72 657 511394 73042 42036242
Throat tightness 32.41 11.72 212 511839 9387 42099897
Drug abuse 32.29 11.72 1554 510497 103217 42006067
Labelled drug-drug interaction medication error 32.04 11.72 89 511962 15493 42093791
Cerebrovascular accident 32.03 11.72 905 511146 96255 42013029
Pemphigus 32.00 11.72 73 511978 1933 42107351
Liver function test abnormal 31.92 11.72 557 511494 31834 42077450
Neurological symptom 31.88 11.72 44 512007 9947 42099337
Disease recurrence 31.81 11.72 217 511834 29461 42079823
Graft versus host disease in gastrointestinal tract 31.81 11.72 11 512040 5132 42104152
Injection site bruising 31.77 11.72 56 511995 11469 42097815
Sinusitis 31.66 11.72 768 511283 46524 42062760
Visual acuity reduced 31.28 11.72 107 511944 17443 42091841
Acidosis 31.01 11.72 253 511798 12026 42097258
Diffuse large B-cell lymphoma recurrent 31.00 11.72 10 512041 4876 42104408
Apparent death 30.91 11.72 4 512047 3704 42105580
Dry skin 30.89 11.72 402 511649 47936 42061348
Renal cortical necrosis 30.85 11.72 23 512028 182 42109102
Lipodystrophy acquired 30.57 11.72 3 512048 3447 42105837
Cystitis haemorrhagic 30.34 11.72 26 512025 7303 42101981
Bone marrow failure 30.24 11.72 253 511798 32840 42076444
Pulmonary fibrosis 30.16 11.72 192 511859 26489 42082795
Livedo reticularis 30.00 11.72 87 511964 2677 42106607
Cytomegalovirus viraemia 29.92 11.72 49 512002 10328 42098956
Injection site swelling 29.90 11.72 104 511947 16869 42092415
Drug reaction with eosinophilia and systemic symptoms 29.61 11.72 688 511363 41387 42067897
Infusion site swelling 29.58 11.72 97 511954 3195 42106089
Hypothermia 29.55 11.72 254 511797 12261 42097023
Akathisia 29.53 11.72 50 512001 10401 42098883
Drug intolerance 28.88 11.72 740 511311 79684 42029600
Ventricular tachycardia 28.28 11.72 229 511822 29931 42079353
Bezoar 28.08 11.72 53 511998 1223 42108061
Jaundice 27.97 11.72 577 511474 34012 42075272
Cardiac disorder 27.69 11.72 417 511634 48515 42060769
Ear pruritus 27.68 11.72 39 512012 698 42108586
Intraocular pressure increased 27.65 11.72 22 512029 6411 42102873
Erythema multiforme 27.63 11.72 210 511841 9767 42099517
Cytomegalovirus infection reactivation 27.60 11.72 58 511993 11120 42098164
Coagulation factor VII level decreased 27.44 11.72 18 512033 113 42109171
Constipation 27.09 11.72 2283 509768 160008 41949276
Viral mutation identified 26.81 11.72 4 512047 3327 42105957
Atrial fibrillation 26.37 11.72 1389 510662 138204 41971080
Intentional self-injury 26.28 11.72 289 511762 14913 42094371
Respiratory arrest 25.97 11.72 483 511568 27941 42081343
Neuropathy peripheral 25.89 11.72 981 511070 100872 42008412
Respiratory rate increased 25.85 11.72 224 511827 10838 42098446
Asphyxia 25.79 11.72 180 511871 8146 42101138
Hyperhidrosis 25.10 11.72 1329 510722 89183 42020101
Thrombotic microangiopathy 25.09 11.72 92 511959 14690 42094594
Blood alkaline phosphatase increased 24.77 11.72 553 511498 33044 42076240
Paradoxical drug reaction 24.73 11.72 13 512038 4725 42104559
Immunosuppressant drug level increased 24.72 11.72 34 512017 7697 42101587
Nasal necrosis 24.53 11.72 13 512038 51 42109233
Mydriasis 24.51 11.72 185 511866 8585 42100699
Physical deconditioning 24.49 11.72 74 511977 2331 42106953
Lip oedema 24.41 11.72 89 511962 3095 42106189
Vanishing bile duct syndrome 24.41 11.72 63 511988 1808 42107476
Hypothyroidism 24.30 11.72 257 511794 31827 42077457
Low birth weight baby 24.29 11.72 52 511999 9903 42099381
Infusion site erythema 24.27 11.72 97 511954 3525 42105759
Injection site haemorrhage 24.15 11.72 67 511984 11669 42097615
Glucose-6-phosphate dehydrogenase deficiency 24.14 11.72 22 512029 237 42109047
Anion gap abnormal 24.12 11.72 28 512023 409 42108875
Acute kidney injury 23.88 11.72 4878 507173 362459 41746825
Unresponsive to stimuli 23.82 11.72 519 511532 30884 42078400
Hepatic encephalopathy 23.75 11.72 302 511749 16140 42093144
Therapy cessation 23.71 11.72 146 511905 20304 42088980
Agranulocytosis 23.56 11.72 507 511544 30105 42079179
Skin exfoliation 23.55 11.72 354 511697 41199 42068085
Torsade de pointes 23.47 11.72 42 512009 8552 42100732
Depression 23.38 11.72 1096 510955 110267 41999017
Prostatic specific antigen increased 23.38 11.72 114 511937 16811 42092473
Body temperature fluctuation 23.10 11.72 57 511994 1590 42107694
Hepatorenal failure 23.04 11.72 33 512018 600 42108684
Miosis 22.96 11.72 255 511796 13191 42096093
Symmetrical drug-related intertriginous and flexural exanthema 22.87 11.72 39 512012 829 42108455
Oral pruritus 22.69 11.72 30 512021 504 42108780
Coagulation factor V level decreased 22.42 11.72 21 512030 235 42109049
Prothrombin time abnormal 22.38 11.72 39 512012 844 42108440
Injection site reaction 22.23 11.72 105 511946 15616 42093668
Graft versus host disease in skin 22.18 11.72 18 512033 5194 42104090
Nightmare 22.15 11.72 423 511628 24589 42084695
Electrocardiogram QT prolonged 22.12 11.72 424 511627 47521 42061763
Periportal oedema 21.82 11.72 13 512038 67 42109217
Vascular stent thrombosis 21.73 11.72 6 512045 3236 42106048
Angina pectoris 21.60 11.72 272 511779 32624 42076660
COVID-19 treatment 21.53 11.72 21 512030 248 42109036
Underdose 21.46 11.72 115 511936 16551 42092733
Psychiatric decompensation 21.43 11.72 12 512039 4210 42105074
Prothrombin time prolonged 21.22 11.72 190 511861 9279 42100005
Unintentional medical device removal 21.21 11.72 6 512045 3185 42106099
JC virus infection 21.21 11.72 5 512046 2999 42106285
Cryopyrin associated periodic syndrome 21.20 11.72 14 512037 89 42109195
Heart rate irregular 21.18 11.72 290 511761 15760 42093524
Anaemia 21.16 11.72 2998 509053 277280 41832004
Head discomfort 21.06 11.72 120 511931 5057 42104227
Prescription form tampering 20.96 11.72 31 512020 581 42108703
Failure to suspend medication 20.93 11.72 25 512026 377 42108907
Blood ethanol increased 20.90 11.72 27 512024 443 42108841
Polyomavirus-associated nephropathy 20.81 11.72 22 512029 5593 42103691
Infection 20.81 11.72 1117 510934 110951 41998333
Cytomegalovirus chorioretinitis 20.80 11.72 15 512036 4596 42104688
Candida infection 20.76 11.72 163 511888 21447 42087837
Substance abuse 20.64 11.72 180 511871 8725 42100559
Analgesic therapy 20.55 11.72 29 512022 6495 42102789
Reversible cerebral vasoconstriction syndrome 20.50 11.72 34 512017 706 42108578
Therapeutic product effect variable 20.38 11.72 6 512045 3103 42106181
Infusion site bruising 20.28 11.72 39 512012 913 42108371
Hand deformity 20.17 11.72 10 512041 3758 42105526
Ejection fraction decreased 20.12 11.72 169 511882 21918 42087366
Mucocutaneous disorder 20.05 11.72 17 512034 165 42109119
Use of accessory respiratory muscles 20 11.72 28 512023 498 42108786
Nodule 19.99 11.72 80 511971 12454 42096830
Kidney transplant rejection 19.85 11.72 47 512004 8636 42100648
Hypertransaminasaemia 19.59 11.72 183 511868 9044 42100240
Antipsychotic drug level below therapeutic 19.56 11.72 7 512044 3197 42106087
Faeces discoloured 19.52 11.72 300 511751 16714 42092570
Mucormycosis 19.43 11.72 35 512016 7108 42102176
Metastases to liver 19.22 11.72 116 511935 16210 42093074
Cytopenia 19.22 11.72 127 511924 17370 42091914
Synovitis 19.18 11.72 109 511942 15458 42093826
Injection site mass 19.14 11.72 47 512004 8528 42100756
Cardiotoxicity 18.92 11.72 38 512013 7407 42101877
Hepatitis E 18.88 11.72 7 512044 3127 42106157
Blood immunoglobulin G decreased 18.87 11.72 66 511985 2248 42107036
Memory impairment 18.86 11.72 459 511592 49763 42059521
Incorrect drug administration rate 18.83 11.72 63 511988 2097 42107187
Skin toxicity 18.81 11.72 31 512020 6518 42102766
Intracranial pressure increased 18.79 11.72 108 511943 4566 42104718
Thrombosis 18.73 11.72 654 511397 67857 42041427
Accidental exposure to product by child 18.65 11.72 51 512000 1516 42107768
No adverse event 18.65 11.72 343 511708 38678 42070606
Accidental death 18.65 11.72 80 511971 3003 42106281
Drug abuser 18.64 11.72 88 511963 3443 42105841
Hyperbilirubinaemia 18.63 11.72 350 511701 20285 42088999
Mucosal inflammation 18.61 11.72 451 511600 48923 42060361
Serum sickness 18.61 11.72 64 511987 2161 42107123
Posterior reversible encephalopathy syndrome 18.50 11.72 85 511966 12736 42096548
Drug effective for unapproved indication 18.49 11.72 32 512019 6601 42102683
Disinhibition 18.47 11.72 12 512039 3883 42105401
Carotid artery occlusion 18.46 11.72 14 512037 4180 42105104
Feeling hot 18.42 11.72 390 511661 23092 42086192
Factor VIII inhibition 18.39 11.72 21 512030 301 42108983
Prostate cancer stage IV 18.39 11.72 4 512047 2536 42106748
Hyper IgE syndrome 18.34 11.72 16 512035 162 42109122
Periorbital oedema 18.33 11.72 107 511944 4550 42104734
Sphincter of Oddi dysfunction 18.30 11.72 18 512033 215 42109069
Product administration error 18.28 11.72 316 511735 18027 42091257
Product prescribing error 18.25 11.72 213 511838 25899 42083385
Dose calculation error 18.21 11.72 12 512039 76 42109208
Device difficult to use 18.19 11.72 17 512034 4579 42104705
Parvimonas micra infection 18.12 11.72 11 512040 59 42109225
Dyspnoea exertional 18.11 11.72 461 511590 49687 42059597
Delusion of grandeur 18.10 11.72 59 511992 1937 42107347
Hyperaesthesia 18.04 11.72 128 511923 5824 42103460
Fibrin D dimer increased 18.00 11.72 112 511939 4873 42104411
Patent ductus arteriosus 17.89 11.72 86 511965 3390 42105894
Device use error 17.86 11.72 8 512043 3189 42106095
Aplasia pure red cell 17.85 11.72 37 512014 7129 42102155
Leukaemia 17.84 11.72 26 512025 5746 42103538
Brain death 17.79 11.72 78 511973 2956 42106328
Bone erosion 17.77 11.72 16 512035 4387 42104897
Injection site erythema 17.73 11.72 156 511895 20039 42089245
Infusion site discomfort 17.73 11.72 23 512028 379 42108905
Monocyte chemotactic protein-1 increased 17.72 11.72 22 512029 346 42108938
Lung neoplasm malignant 17.67 11.72 146 511905 19001 42090283
Complications of transplanted kidney 17.64 11.72 23 512028 5327 42103957
Headache 17.62 11.72 3199 508852 236170 41873114
Neck pain 17.62 11.72 479 511572 29535 42079749
Dizziness 17.56 11.72 2677 509374 246577 41862707
Viral load increased 17.54 11.72 7 512044 2990 42106294
Gamma-glutamyltransferase increased 17.51 11.72 513 511538 31984 42077300
Alpha tumour necrosis factor increased 17.49 11.72 22 512029 351 42108933
Patient uncooperative 17.49 11.72 30 512021 641 42108643
Oedema peripheral 17.33 11.72 1403 510648 134673 41974611
Cerebral artery thrombosis 17.28 11.72 43 512008 1206 42108078
Face oedema 17.26 11.72 245 511806 13421 42095863
Hypoxia 17.25 11.72 1014 511037 68772 42040512
Macrophages increased 17.18 11.72 15 512036 152 42109132
Transplant failure 17.17 11.72 14 512037 4030 42105254
Erythema 17.13 11.72 1524 510527 107269 42002015
Gastrointestinal haemorrhage 17.04 11.72 980 511071 96746 42012538
Dependent personality disorder 17.03 11.72 11 512040 67 42109217
Anaphylactic shock 16.99 11.72 386 511665 23131 42086153
Interstitial lung disease 16.90 11.72 770 511281 77692 42031592
Renal cancer 16.89 11.72 47 512004 8177 42101107
Incorrect dose administered by device 16.86 11.72 6 512045 2750 42106534
Metastasis 16.81 11.72 19 512032 4686 42104598
Transient ischaemic attack 16.62 11.72 295 511756 33444 42075840
Nipple inflammation 16.57 11.72 10 512041 53 42109231
Acute myeloid leukaemia 16.56 11.72 179 511872 22077 42087207
Systemic infection 16.53 11.72 23 512028 5182 42104102
Unevaluable event 16.51 11.72 301 511750 33987 42075297
Neurotoxicity 16.50 11.72 193 511858 23458 42085826
Incision site complication 16.43 11.72 20 512031 308 42108976
Acute graft versus host disease in intestine 16.38 11.72 14 512037 3937 42105347
Infusion site rash 16.35 11.72 29 512022 637 42108647
Injection site pruritus 16.32 11.72 58 511993 9347 42099937
Hemiparesis 16.26 11.72 132 511919 17244 42092040
Chronic obstructive pulmonary disease 16.22 11.72 607 511444 62507 42046777
Type I hypersensitivity 16.15 11.72 60 511991 2106 42107178
Specific gravity urine increased 16.14 11.72 15 512036 166 42109118
Dyspnoea 16.12 11.72 4911 507140 437710 41671574
Myelodysplastic syndrome 16.10 11.72 185 511866 22560 42086724
Haematemesis 16.08 11.72 476 511575 29723 42079561
Lymph node calcification 16.03 11.72 14 512037 142 42109142
Angular cheilitis 16.01 11.72 16 512035 195 42109089
Neutrophil percentage increased 15.98 11.72 56 511995 1909 42107375
Hyperlipasaemia 15.96 11.72 27 512024 570 42108714
Clostridium test positive 15.88 11.72 117 511934 5388 42103896
Postoperative delirium 15.87 11.72 27 512024 573 42108711
Aptyalism 15.85 11.72 22 512029 388 42108896
Platelet count decreased 15.83 11.72 1441 510610 137140 41972144
Hepatitis toxic 15.83 11.72 67 511984 2500 42106784
Arrhythmia 15.82 11.72 366 511685 39951 42069333
Blood pH decreased 15.77 11.72 62 511989 2236 42107048
Neuroblastoma recurrent 15.77 11.72 22 512029 390 42108894
Dermatitis atopic 15.75 11.72 86 511965 12318 42096966
Major depression 15.73 11.72 115 511936 5283 42104001
Epstein-Barr virus infection 15.51 11.72 62 511989 9656 42099628
Nasal septum perforation 15.47 11.72 17 512034 233 42109051
Product storage error 15.41 11.72 75 511976 11065 42098219
Dyspnoea at rest 15.36 11.72 17 512034 4232 42105052
Crystal urine present 15.32 11.72 23 512028 437 42108847
Type IIa hyperlipidaemia 15.30 11.72 19 512032 299 42108985
Embolic stroke 15.29 11.72 23 512028 5017 42104267
Angioedema 15.25 11.72 640 511411 41837 42067447
Urine sodium decreased 15.21 11.72 14 512037 153 42109131
Allergy test negative 15.21 11.72 14 512037 153 42109131
Haemarthrosis 15.18 11.72 91 511960 3907 42105377
Tooth injury 15.18 11.72 41 512010 1210 42108074
Acute myeloid leukaemia recurrent 15.11 11.72 12 512039 3500 42105784
Negative pressure pulmonary oedema 15.06 11.72 27 512024 598 42108686
Immune effector cell-associated neurotoxicity syndrome 15.06 11.72 177 511874 9284 42100000
Full blood count decreased 15.04 11.72 166 511885 20394 42088890
Psychotic symptom 14.97 11.72 5 512046 2385 42106899
Systemic mycosis 14.95 11.72 5 512046 2382 42106902
Fungal infection 14.92 11.72 158 511893 19564 42089720
Colour blindness acquired 14.87 11.72 12 512039 108 42109176
Cerebral palsy 14.82 11.72 21 512030 378 42108906
Maternal exposure before pregnancy 14.81 11.72 37 512014 1040 42108244
Hyperlactacidaemia 14.80 11.72 99 511952 4417 42104867
Sedation 14.80 11.72 475 511576 30000 42079284
Jaundice cholestatic 14.79 11.72 111 511940 5142 42104142
Neoplasm progression 14.78 11.72 252 511799 28748 42080536
Anion gap increased 14.78 11.72 57 511994 2037 42107247
Inappropriate schedule of product administration 14.73 11.72 1341 510710 94561 42014723
Pneumocystis jirovecii infection 14.70 11.72 8 512043 2852 42106432
Adulterated product 14.65 11.72 30 512021 736 42108548
Osteonecrosis 14.63 11.72 121 511930 15744 42093540
Cerebral atrophy congenital 14.61 11.72 10 512041 68 42109216
Beta haemolytic streptococcal infection 14.61 11.72 33 512018 868 42108416
Lymphoproliferative disorder 14.61 11.72 11 512040 3296 42105988
Fear 14.49 11.72 75 511976 10890 42098394
Blood creatine phosphokinase increased 14.49 11.72 456 511595 47882 42061402
Osteolysis 14.46 11.72 13 512038 3567 42105717
Ataxia 14.41 11.72 124 511927 16001 42093283
Mycobacterial infection 14.40 11.72 7 512044 2661 42106623
Meningitis cryptococcal 14.40 11.72 11 512040 3272 42106012
Ear infection 14.39 11.72 225 511826 12579 42096705
Syncope 14.38 11.72 1014 511037 98392 42010892
Lymphocyte count 14.30 11.72 16 512035 224 42109060
Diabetic ketoacidosis 14.29 11.72 186 511865 22181 42087103
Status epilepticus 14.27 11.72 119 511932 15459 42093825
Pneumonia 14.26 11.72 4698 507353 417451 41691833
Red blood cell sedimentation rate abnormal 14.25 11.72 15 512036 3821 42105463
Encephalopathy 14.22 11.72 620 511431 40713 42068571
Erectile dysfunction 14.20 11.72 212 511839 24701 42084583
Retinal haemorrhage 14.20 11.72 30 512021 5740 42103544
Hepatitis C 14.14 11.72 68 511983 10065 42099219
Pneumatosis intestinalis 14.11 11.72 22 512029 4730 42104554
Hepatitis B 14.04 11.72 38 512013 6673 42102611
Enterocolitis infectious 14.01 11.72 54 511997 1929 42107355
Pseudomonas infection 13.98 11.72 123 511928 15800 42093484
Epstein-Barr viraemia 13.98 11.72 5 512046 2284 42107000
Tuberculosis 13.96 11.72 68 511983 10031 42099253
Gastric ulcer perforation 13.95 11.72 36 512015 1033 42108251
Ear injury 13.93 11.72 8 512043 38 42109246
Hepatocellular carcinoma 13.91 11.72 51 512000 8143 42101141
Social avoidant behaviour 13.84 11.72 12 512039 3352 42105932
Band neutrophil percentage decreased 13.84 11.72 6 512045 13 42109271
Gingival hypertrophy 13.79 11.72 6 512045 2433 42106851
Varicella zoster virus infection 13.78 11.72 7 512044 2594 42106690
Malignant neoplasm progression 13.74 11.72 1118 510933 107282 42002002
Eyelid ptosis 13.73 11.72 38 512013 6623 42102661
Cardiomyopathy 13.70 11.72 156 511895 19054 42090230
Transplant dysfunction 13.67 11.72 12 512039 3331 42105953
PCO2 decreased 13.63 11.72 50 512001 1744 42107540
Acute phase reaction 13.57 11.72 13 512038 150 42109134
General physical health deterioration 13.56 11.72 1600 510451 149646 41959638
Testicular infarction 13.53 11.72 9 512042 58 42109226
Obsessive-compulsive disorder 13.50 11.72 39 512012 6704 42102580
Ductus arteriosus stenosis foetal 13.49 11.72 14 512037 179 42109105
Pallor 13.45 11.72 448 511603 28438 42080846
Renal papillary necrosis 13.37 11.72 13 512038 153 42109131
Nipple disorder 13.35 11.72 15 512036 211 42109073
Discoloured vomit 13.34 11.72 29 512022 743 42108541
Fragile X syndrome 13.31 11.72 8 512043 42 42109242
Interleukin level increased 13.30 11.72 32 512019 878 42108406
Parkinsonism 13.30 11.72 74 511977 10549 42098735
Hepatic cirrhosis 13.28 11.72 162 511889 19540 42089744
Coronary arterial stent insertion 13.28 11.72 17 512034 3968 42105316
Viral haemorrhagic cystitis 13.26 11.72 3 512048 1851 42107433
Cytomegalovirus colitis 13.24 11.72 17 512034 3964 42105320
Palmar-plantar erythrodysaesthesia syndrome 13.21 11.72 171 511880 20411 42088873
Drug screen positive 13.20 11.72 90 511961 4041 42105243
Asthenia 13.05 11.72 3082 508969 277711 41831573
Ureteric haemorrhage 13.03 11.72 15 512036 217 42109067
Myoglobin blood increased 13.01 11.72 15 512036 3667 42105617
Sexual dysfunction 12.98 11.72 40 512011 6735 42102549
Psychotic disorder 12.96 11.72 260 511791 28948 42080336
Brain natriuretic peptide increased 12.95 11.72 40 512011 6730 42102554
Second primary malignancy 12.93 11.72 65 511986 9510 42099774
Agitation 12.90 11.72 918 511133 63396 42045888
Feeling abnormal 12.86 11.72 696 511355 69090 42040194
Psychomotor skills impaired 12.85 11.72 27 512024 5177 42104107
Self-medication 12.83 11.72 75 511976 3191 42106093
Chronic gastrointestinal bleeding 12.82 11.72 18 512033 321 42108963
Nausea 12.80 11.72 5119 506932 391680 41717604
Carotid arteriosclerosis 12.77 11.72 6 512045 2326 42106958
Myocardial ischaemia 12.76 11.72 144 511907 17618 42091666
Feeling cold 12.75 11.72 223 511828 12750 42096534
Skin degenerative disorder 12.74 11.72 6 512045 17 42109267
Specific gravity urine decreased 12.72 11.72 9 512042 65 42109219
Cholangitis 12.63 11.72 190 511861 10537 42098747
Right ventricle outflow tract obstruction 12.61 11.72 8 512043 47 42109237
Visual impairment 12.61 11.72 408 511643 42705 42066579
Post concussion syndrome 12.60 11.72 13 512038 165 42109119
Cerebral haemorrhage 12.56 11.72 364 511687 38602 42070682
Tumour fistulisation 12.56 11.72 11 512040 112 42109172
Granulomatosis with polyangiitis 12.55 11.72 43 512008 1449 42107835
Blood lactic acid 12.54 11.72 18 512033 328 42108956
Stomatitis 12.50 11.72 486 511565 49843 42059441
Brain scan abnormal 12.50 11.72 38 512013 1201 42108083
Acquired epidermolysis bullosa 12.40 11.72 7 512044 32 42109252
Pneumonia cytomegaloviral 12.35 11.72 19 512032 4107 42105177
Allergic cough 12.35 11.72 8 512043 49 42109235
Incorrect dosage administered 12.32 11.72 47 512004 1671 42107613
Gastrointestinal toxicity 12.22 11.72 18 512033 3961 42105323
Salmonella bacteraemia 12.20 11.72 21 512030 450 42108834
Prostate cancer stage II 12.19 11.72 6 512045 2264 42107020
Substance use disorder 12.16 11.72 29 512022 5316 42103968
Intervertebral discitis 12.16 11.72 71 511980 3019 42106265
Sudden infant death syndrome 12.12 11.72 17 512034 303 42108981
Leukopenia 12.06 11.72 755 511296 73991 42035293
Consciousness fluctuating 12.04 11.72 39 512012 1276 42108008
Exposure via ingestion 12.02 11.72 54 511997 2068 42107216
Oesophageal obstruction 12.02 11.72 24 512027 578 42108706
Disseminated aspergillosis 11.98 11.72 3 512048 1727 42107557
Osteonecrosis of jaw 11.95 11.72 159 511892 18890 42090394
Red blood cell sedimentation rate increased 11.95 11.72 70 511981 9854 42099430
Respiratory failure 11.93 11.72 1352 510699 126780 41982504
Laboratory test abnormal 11.93 11.72 199 511852 22779 42086505
Sulphaemoglobinaemia 11.91 11.72 7 512044 35 42109249
Epilepsy 11.90 11.72 232 511819 25939 42083345
Tenosynovitis 11.90 11.72 24 512027 4671 42104613
Kussmaul respiration 11.88 11.72 10 512041 96 42109188
Diabetic bullosis 11.83 11.72 6 512045 21 42109263
Accidental exposure to product 11.81 11.72 173 511878 20220 42089064
Peritonitis bacterial 11.76 11.72 43 512008 6872 42102412
Melanoderma 11.73 11.72 13 512038 180 42109104

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 4964.50 11.03 16306 1519614 464249 108589130
Intentional overdose 3513.09 11.03 6471 1529449 126030 108927349
Completed suicide 3281.80 11.03 9055 1526865 233326 108820053
Exposure to toxic agent 2274.04 11.03 1684 1534236 11174 109042205
Acute hepatic failure 2213.50 11.03 2632 1533288 33836 109019543
Analgesic drug level increased 1562.74 11.03 860 1535060 3086 109050293
Overdose 1424.56 11.03 6728 1529192 227066 108826313
Suicide attempt 1368.08 11.03 3833 1532087 99561 108953818
Poisoning deliberate 1270.78 11.03 1695 1534225 24636 109028743
Drug ineffective 1163.35 11.03 14546 1521374 1505994 107547385
Hepatocellular injury 1085.69 11.03 2263 1533657 48379 109005000
Hepatic cytolysis 780.83 11.03 2094 1533826 52959 109000420
Intentional product misuse 762.93 11.03 3761 1532159 129143 108924236
Metabolic acidosis 679.65 11.03 2968 1532952 96776 108956603
Blood pressure fluctuation 657.05 11.03 2410 1533510 72414 108980965
Myelosuppression 622.07 11.03 265 1535655 94075 108959304
Infusion related reaction 594.48 11.03 7988 1527932 373174 108680205
Injection site pain 494.49 11.03 1084 1534836 176838 108876541
Cholestasis 491.05 11.03 1986 1533934 62532 108990847
Drug resistance 402.09 11.03 140 1535780 56234 108997145
Pyroglutamic acidosis 377.26 11.03 276 1535644 1792 109051587
Coma 374.90 11.03 2863 1533057 115006 108938373
Somnolence 343.92 11.03 5925 1529995 291524 108761855
Product dose omission issue 330.65 11.03 2866 1533054 318916 108734463
Throat irritation 323.36 11.03 1538 1534382 52014 109001365
Hepatitis acute 313.00 11.03 759 1535161 18007 109035372
Coagulopathy 311.02 11.03 1259 1534661 39652 109013727
Disease progression 300.18 11.03 2068 1533852 241966 108811413
Heart rate decreased 299.87 11.03 2074 1533846 80682 108972697
Accidental overdose 290.30 11.03 1457 1534463 50377 109003002
Anion gap 289.76 11.03 232 1535688 1753 109051626
Prothrombin time ratio decreased 289.36 11.03 212 1535708 1380 109051999
Vomiting 282.28 11.03 15400 1520520 895275 108158104
Blood pressure diastolic abnormal 274.19 11.03 886 1535034 24929 109028450
Hepatotoxicity 263.17 11.03 1644 1534276 61756 108991623
Device expulsion 261.10 11.03 55 1535865 30836 109022543
Hepatic failure 259.94 11.03 1741 1534179 66998 108986381
Hepatitis fulminant 257.33 11.03 442 1535478 8118 109045261
Depressed level of consciousness 253.55 11.03 2529 1533391 109749 108943630
Blood pressure increased 252.04 11.03 5013 1530907 253360 108800019
Blood pressure systolic abnormal 249.71 11.03 837 1535083 24013 109029366
Injection site erythema 246.84 11.03 592 1535328 93584 108959795
Blood pressure systolic increased 239.82 11.03 1972 1533948 81019 108972360
Suspected suicide 238.97 11.03 601 1535319 14598 109038781
Prothrombin time shortened 235.92 11.03 272 1535648 3374 109050005
Oxygen saturation decreased 234.51 11.03 3266 1532654 153716 108899663
Cardiac failure congestive 233.71 11.03 1189 1534731 149811 108903568
Therapeutic product effect incomplete 227.73 11.03 1998 1533922 221807 108831572
Medication error 220.16 11.03 2336 1533584 103030 108950349
Product use in unapproved indication 213.25 11.03 4661 1531259 442716 108610663
Cytokine release syndrome 203.90 11.03 1672 1534248 68634 108984745
Wrong technique in product usage process 189.43 11.03 602 1535318 86746 108966633
Heart rate increased 182.24 11.03 2909 1533011 140925 108912454
Mixed liver injury 181.98 11.03 470 1535450 11609 109041770
Myocardial infarction 181.88 11.03 1746 1534174 190337 108863042
Drug ineffective for unapproved indication 175.96 11.03 781 1535139 102057 108951322
Cardiac failure 169.07 11.03 1726 1534194 185900 108867479
Fixed eruption 166.39 11.03 247 1535673 3985 109049394
Renal impairment 166.34 11.03 1742 1534178 186703 108866676
Hepatitis 162.04 11.03 1939 1533981 88115 108965264
Injection site swelling 159.09 11.03 392 1535528 61398 108991981
Intentional self-injury 158.11 11.03 975 1534945 36454 109016925
Ear pruritus 157.39 11.03 326 1535594 6934 109046445
Pyroglutamate increased 156.78 11.03 103 1535817 547 109052832
Treatment failure 156.56 11.03 2807 1533113 274427 108778952
Cytomegalovirus infection 154.25 11.03 328 1535592 54116 108999263
Toxic epidermal necrolysis 153.32 11.03 1328 1534592 55399 108997980
Hepatic necrosis 152.51 11.03 389 1535531 9533 109043846
Body temperature increased 149.52 11.03 1284 1534636 53429 108999950
Therapy partial responder 147.75 11.03 178 1535742 36883 109016496
Therapy non-responder 146.75 11.03 1435 1534485 155872 108897507
Cardio-respiratory arrest 146.44 11.03 2342 1533578 113494 108939885
Poisoning 145.64 11.03 793 1535127 28312 109025067
Abdominal pain 142.95 11.03 8595 1527325 504394 108548985
Post transplant lymphoproliferative disorder 142.25 11.03 23 1535897 15590 109037789
Transaminases increased 141.71 11.03 1425 1534495 61965 108991414
International normalised ratio increased 140.54 11.03 1832 1534088 84940 108968439
Hepatitis cholestatic 140.27 11.03 549 1535371 17017 109036362
Blood pressure diastolic decreased 139.96 11.03 916 1535004 34969 109018410
Multiple-drug resistance 139.08 11.03 12 1535908 13223 109040156
Off label use 138.22 11.03 18497 1517423 1481688 107571691
Condition aggravated 135.58 11.03 8593 1527327 726243 108327136
Hospitalisation 135.40 11.03 1294 1534626 141199 108912180
Pathogen resistance 134.71 11.03 39 1535881 17633 109035746
Therapy interrupted 132.29 11.03 311 1535609 49511 109003868
Rheumatoid arthritis 132.06 11.03 5251 1530669 294362 108759017
Respiratory depression 131.66 11.03 828 1535092 31173 109022206
Haematotoxicity 131.50 11.03 64 1535856 21018 109032361
Injection site pruritus 126.70 11.03 332 1535588 50926 109002453
Urticaria 122.85 11.03 5510 1530410 313347 108740032
Chills 121.62 11.03 3488 1532432 187092 108866287
Acute generalised exanthematous pustulosis 117.81 11.03 604 1535316 21060 109032319
Injection site reaction 115.36 11.03 743 1535177 88327 108965052
Urine abnormality 115.14 11.03 332 1535588 8764 109044615
Red blood cell sedimentation rate abnormal 114.29 11.03 103 1535817 24406 109028973
Diarrhoea 113.99 11.03 13974 1521946 1125531 107927848
Injection site bruising 112.77 11.03 351 1535569 50912 109002467
Blood pressure diastolic increased 112.69 11.03 539 1535381 18268 109035111
Tachycardia 112.25 11.03 4024 1531896 222621 108830758
Full blood count abnormal 112.17 11.03 400 1535520 55652 108997727
Hepatic encephalopathy 111.86 11.03 724 1535196 27532 109025847
Drug interaction 111.19 11.03 5744 1530176 494439 108558940
Hypotension 107.47 11.03 8558 1527362 515291 108538088
Transplant rejection 106.70 11.03 110 1535810 24457 109028922
Bone marrow failure 105.93 11.03 428 1535492 57420 108995959
Alanine aminotransferase increased 105.54 11.03 3320 1532600 180453 108872926
BK virus infection 101.62 11.03 28 1535892 13078 109040301
Loss of personal independence in daily activities 99.18 11.03 1475 1534445 148545 108904834
Aspergillus infection 99.00 11.03 126 1535794 25490 109027889
Confusional state 97.62 11.03 7666 1528254 461014 108592365
Drug dose omission by device 95.31 11.03 41 1535879 14475 109038904
Therapeutic response decreased 94.80 11.03 869 1535051 95630 108957749
Therapy cessation 92.53 11.03 316 1535604 44541 109008838
Cholecystitis chronic 91.94 11.03 316 1535604 9184 109044195
Pulmonary alveolar haemorrhage 91.22 11.03 87 1535833 20063 109033316
Acute graft versus host disease in skin 91.02 11.03 19 1535901 10721 109042658
Graft versus host disease 90.15 11.03 77 1535843 18729 109034650
Device difficult to use 88.92 11.03 78 1535842 18727 109034652
Thrombotic microangiopathy 88.22 11.03 169 1535751 28980 109024399
Urine leukocyte esterase positive 88.01 11.03 175 1535745 3611 109049768
Posterior reversible encephalopathy syndrome 87.81 11.03 214 1535706 33647 109019732
Anaemia 87.21 11.03 6479 1529441 540607 108512772
Acute graft versus host disease 86.80 11.03 35 1535885 12846 109040533
Drug hypersensitivity 86.37 11.03 5294 1530626 448796 108604583
Immune reconstitution inflammatory syndrome 85.96 11.03 60 1535860 16166 109037213
Anaphylactic reaction 85.23 11.03 2135 1533785 112165 108941214
Hypocoagulable state 85.23 11.03 140 1535780 2475 109050904
Prostate cancer 84.74 11.03 255 1535665 37386 109015993
Pharyngeal paraesthesia 84.30 11.03 181 1535739 3951 109049428
Malignant neoplasm progression 82.95 11.03 1819 1534101 172748 108880631
Product monitoring error 81.67 11.03 13 1535907 8914 109044465
Chronic graft versus host disease 81.66 11.03 16 1535904 9441 109043938
Neoplasm progression 81.53 11.03 543 1535377 64052 108989327
Sleep disorder due to a general medical condition 81.36 11.03 409 1535511 51703 109001676
Prothrombin time prolonged 80.19 11.03 461 1535459 16800 109036579
Bladder cancer 79.27 11.03 99 1535821 20193 109033186
Flushing 79.17 11.03 1960 1533960 102776 108950603
Miosis 79.05 11.03 550 1535370 21433 109031946
Drug abuse 77.80 11.03 3108 1532812 174303 108879076
Drug-induced liver injury 77.27 11.03 2200 1533720 117867 108935512
Unintentional medical device removal 77.26 11.03 15 1535905 8908 109044471
Liver injury 77.03 11.03 2681 1533239 147732 108905647
Stevens-Johnson syndrome 76.68 11.03 992 1534928 45909 109007470
Infusion site pruritus 76.62 11.03 196 1535724 4812 109048567
Oesophageal carcinoma 76.54 11.03 32 1535888 11492 109041887
Crystal urine present 75.88 11.03 114 1535806 1860 109051519
White blood cells urine positive 75.21 11.03 253 1535667 7271 109046108
Injection site haemorrhage 74.17 11.03 224 1535696 32804 109020575
Acidosis 73.69 11.03 551 1535369 21980 109031399
Cytomegalovirus viraemia 73.30 11.03 83 1535837 17681 109035698
Angioedema 72.88 11.03 1838 1534082 96662 108956717
Intercepted product preparation error 72.17 11.03 6 1535914 6814 109046565
Eosinophilic granulomatosis with polyangiitis 72.07 11.03 29 1535891 10657 109042722
Rash maculo-papular 71.58 11.03 1438 1534482 72784 108980595
Blood parathyroid hormone decreased 71.22 11.03 47 1535873 13042 109040337
Bronchopulmonary aspergillosis 71.11 11.03 197 1535723 29666 109023713
Device issue 70.75 11.03 244 1535676 34291 109019088
Nocardiosis 70.56 11.03 10 1535910 7476 109045903
Metastases to liver 69.83 11.03 254 1535666 35132 109018247
Diabetes mellitus 69.58 11.03 966 1534954 98415 108954964
Cerebral infarction 69.39 11.03 428 1535492 51410 109001969
Lymphocyte count decreased 69.22 11.03 1149 1534771 56094 108997285
Respiratory arrest 68.59 11.03 1165 1534755 57134 108996245
Ventricular tachycardia 68.46 11.03 410 1535510 49599 109003780
Respiratory rate increased 68.19 11.03 588 1535332 24495 109028884
Psoriasis 68.16 11.03 1453 1534467 138540 108914839
Disease recurrence 67.98 11.03 529 1535391 60255 108993124
Cytomegalovirus infection reactivation 66.96 11.03 94 1535826 18239 109035140
Mucosal inflammation 66.78 11.03 936 1534984 95205 108958174
Septic shock 66.60 11.03 1671 1534249 155857 108897522
Device leakage 66.20 11.03 75 1535845 15973 109037406
Coronary artery disease 65.99 11.03 656 1535264 71034 108982345
Neutropenia 65.79 11.03 4399 1531521 370221 108683158
Forced expiratory volume decreased 65.57 11.03 52 1535868 13124 109040255
Cross sensitivity reaction 65.51 11.03 198 1535722 5369 109048010
Hypothyroidism 65.47 11.03 671 1535249 72228 108981151
Infusion site erythema 65.43 11.03 334 1535586 11625 109041754
Accidental exposure to product 65.34 11.03 416 1535504 49592 109003787
Myelodysplastic syndrome 65.12 11.03 283 1535637 37201 109016178
Product prescribing error 65.04 11.03 431 1535489 50900 109002479
Venoocclusive liver disease 65.02 11.03 69 1535851 15138 109038241
Product storage error 64.86 11.03 127 1535793 21601 109031778
Poor venous access 64.66 11.03 571 1535349 23951 109029428
Sinusitis 63.88 11.03 4866 1531054 291822 108761557
Anion gap abnormal 63.81 11.03 68 1535852 768 109052611
Acute myocardial infarction 63.52 11.03 801 1535119 82976 108970403
Heart rate irregular 62.97 11.03 741 1535179 33533 109019846
Palmar-plantar erythrodysaesthesia syndrome 62.90 11.03 324 1535596 40701 109012678
Unevaluable event 62.76 11.03 523 1535397 58704 108994675
Infusion site pain 62.75 11.03 436 1535484 16983 109036396
Neurotoxicity 62.66 11.03 337 1535583 41870 109011509
Interstitial lung disease 62.47 11.03 1465 1534455 137869 108915510
Respiratory failure 62.05 11.03 2403 1533517 212929 108840450
Urinary sediment present 61.37 11.03 119 1535801 2409 109050970
Pulmonary vasculitis 61.28 11.03 9 1535911 6551 109046828
Dry skin 61.02 11.03 1089 1534831 106564 108946815
Systemic infection 60.95 11.03 30 1535890 9789 109043590
Endophthalmitis 60.71 11.03 19 1535901 8168 109045211
Body temperature decreased 60.71 11.03 782 1535138 36153 109017226
Spirometry abnormal 60.55 11.03 4 1535916 5493 109047886
Cytopenia 59.54 11.03 216 1535704 29900 109023479
Jaundice 58.91 11.03 1153 1534767 58083 108995296
Injection site mass 58.13 11.03 163 1535757 24450 109028929
Mucormycosis 58.05 11.03 38 1535882 10590 109042789
Myopathy 57.70 11.03 167 1535753 24793 109028586
Aspartate aminotransferase increased 57.69 11.03 2746 1533174 157190 108896189
Device use error 57.59 11.03 27 1535893 9062 109044317
Acute lung injury 57.50 11.03 132 1535788 3019 109050360
Mydriasis 57.43 11.03 514 1535406 21643 109031736
Encephalopathy 57.19 11.03 1503 1534417 79552 108973827
Lower respiratory tract infection 56.87 11.03 4014 1531906 239092 108814287
Strongyloidiasis 56.83 11.03 3 1535917 4983 109048396
Nasopharyngitis 56.52 11.03 6281 1529639 388080 108665299
Infusion site extravasation 56.21 11.03 314 1535606 11320 109042059
Injection site warmth 56.17 11.03 97 1535823 17308 109036071
Rheumatoid nodule 56.06 11.03 124 1535796 20172 109033207
Obstructive airways disorder 55.73 11.03 393 1535527 45756 109007623
Granuloma skin 55.56 11.03 45 1535875 11238 109042141
Infusion site swelling 55.55 11.03 278 1535642 9599 109043780
Transplant dysfunction 55.52 11.03 23 1535897 8305 109045074
Device malfunction 55.50 11.03 176 1535744 25382 109027997
Back pain 55.26 11.03 5924 1529996 365072 108688307
Breast cancer stage I 55.04 11.03 17 1535903 7370 109046009
Graft versus host disease in gastrointestinal tract 54.77 11.03 28 1535892 8940 109044439
Brain death 54.58 11.03 208 1535712 6365 109047014
Second primary malignancy 54.46 11.03 105 1535815 17963 109035416
Red blood cell sedimentation rate 54.05 11.03 5 1535915 5209 109048170
Hypothermia 53.92 11.03 581 1535339 25721 109027658
Mycotic allergy 53.73 11.03 9 1535911 5945 109047434
Injection site urticaria 53.69 11.03 98 1535822 17117 109036262
Cardiotoxicity 53.64 11.03 95 1535825 16786 109036593
Treatment noncompliance 53.44 11.03 703 1535217 72287 108981092
Coagulation factor VII level decreased 53.26 11.03 35 1535885 186 109053193
Graft versus host disease in skin 53.11 11.03 24 1535896 8230 109045149
Cell death 52.91 11.03 189 1535731 5602 109047777
Acute myeloid leukaemia 52.40 11.03 312 1535608 37798 109015581
Epstein-Barr virus infection 52.15 11.03 114 1535806 18624 109034755
Neuropathy peripheral 52.01 11.03 1999 1533921 177278 108876101
Cystitis haemorrhagic 51.53 11.03 56 1535864 12153 109041226
Coagulation factor V level decreased 51.15 11.03 55 1535865 628 109052751
Virologic failure 50.67 11.03 5 1535915 4947 109048432
Surgery 50.62 11.03 350 1535570 40933 109012446
Liver function test abnormal 50.53 11.03 1285 1534635 67665 108985714
Immunosuppressant drug level increased 50.35 11.03 53 1535867 11671 109041708
Renal papillary necrosis 50.17 11.03 45 1535875 404 109052975
Panniculitis 50.14 11.03 87 1535833 15495 109037884
Neuritis 50.03 11.03 20 1535900 7379 109046000
Polyomavirus-associated nephropathy 49.49 11.03 26 1535894 8175 109045204
Intentional product use issue 49.11 11.03 4040 1531880 243866 108809513
Cholestatic liver injury 48.33 11.03 217 1535703 7159 109046220
Lymphocyte percentage decreased 48.26 11.03 173 1535747 5137 109048242
Blood alkaline phosphatase increased 48.22 11.03 1309 1534611 69626 108983753
Body temperature fluctuation 48.03 11.03 138 1535782 3635 109049744
Lymphoproliferative disorder 48.01 11.03 20 1535900 7198 109046181
JC virus infection 47.73 11.03 8 1535912 5282 109048097
Visual acuity reduced 47.70 11.03 257 1535663 31916 109021463
Throat tightness 47.67 11.03 691 1535229 32798 109020581
Breast cancer female 47.49 11.03 62 1535858 12406 109040973
Platelet count decreased 47.26 11.03 2667 1533253 227776 108825603
Constipation 47.15 11.03 5668 1530252 352118 108701261
Osteonecrosis 47.05 11.03 275 1535645 33466 109019913
Skin necrosis 46.81 11.03 148 1535772 21364 109032015
Underdose 46.57 11.03 612 1535308 62942 108990437
Metastases to lung 46.53 11.03 164 1535756 22899 109030480
Pancytopenia 46.51 11.03 2407 1533513 207206 108846173
Neutrophil percentage increased 46.31 11.03 162 1535758 4751 109048628
Labelled drug-drug interaction medication error 46.30 11.03 229 1535691 29073 109024306
Exposure via ingestion 45.70 11.03 161 1535759 4739 109048640
Dyspnoea exertional 45.57 11.03 1098 1534822 102962 108950417
Bradypnoea 45.55 11.03 239 1535681 8410 109044969
Pyrexia 45.54 11.03 13552 1522368 884713 108168666
Jaundice cholestatic 45.40 11.03 353 1535567 14255 109039124
Pulmonary hypertension 45.28 11.03 519 1535401 54701 108998678
Hyperthermia 45.06 11.03 473 1535447 20799 109032580
Blood calcium decreased 45.01 11.03 724 1535196 35121 109018258
Lip oedema 44.95 11.03 217 1535703 7383 109045996
Oedema 44.93 11.03 2420 1533500 207556 108845823
Medication overuse headache 44.76 11.03 79 1535841 1484 109051895
Renal cancer 44.52 11.03 70 1535850 12964 109040415
Diffuse large B-cell lymphoma recurrent 44.30 11.03 16 1535904 6283 109047096
Pneumocystis jirovecii pneumonia 44.10 11.03 380 1535540 42355 109011024
Cerebrovascular accident 43.86 11.03 2063 1533857 179221 108874158
Oropharyngeal pain 43.69 11.03 2298 1533622 132978 108920401
Ascites 43.51 11.03 969 1534951 91839 108961540
Basal cell carcinoma 43.45 11.03 410 1535510 44860 109008519
Diabetic ketoacidosis 43.39 11.03 374 1535546 41684 109011695
Intracranial pressure increased 42.97 11.03 272 1535648 10263 109043116
Rebound effect 42.95 11.03 88 1535832 14718 109038661
Thrombosis 42.92 11.03 1164 1534756 107498 108945881
Hypertransaminasaemia 42.63 11.03 520 1535400 23735 109029644
Local anaesthetic systemic toxicity 42.61 11.03 12 1535908 5525 109047854
Hepatitis toxic 42.47 11.03 179 1535741 5742 109047637
Ovarian hyperstimulation syndrome 42.41 11.03 11 1535909 5349 109048030
Nasal necrosis 42.33 11.03 29 1535891 167 109053212
Generalised bullous fixed drug eruption 42.28 11.03 54 1535866 750 109052629
Injection site induration 41.94 11.03 58 1535862 11325 109042054
Oral pruritus 41.85 11.03 121 1535799 3199 109050180
Device dislocation 41.79 11.03 263 1535657 31441 109021938
Colorectal cancer 41.67 11.03 39 1535881 9075 109044304
Glycosylated haemoglobin increased 41.22 11.03 178 1535742 23441 109029938
Syringe issue 40.97 11.03 43 1535877 9482 109043897
Enthesopathy 40.76 11.03 69 1535851 12409 109040970
Accidental exposure to product by child 40.74 11.03 117 1535803 3081 109050298
Kidney transplant rejection 40.35 11.03 65 1535855 11922 109041457
Asthma 40.30 11.03 2961 1532959 247330 108806049
Bezoar 40.24 11.03 136 1535784 3918 109049461
Exposure via skin contact 39.98 11.03 76 1535844 13071 109040308
Orthostatic hypotension 39.64 11.03 1203 1534717 65046 108988333
Drug effective for unapproved indication 39.59 11.03 86 1535834 14081 109039298
Pneumonia 39.45 11.03 11213 1524707 865501 108187878
Drug intolerance 39.43 11.03 4993 1530927 401519 108651860
Unresponsive to stimuli 39.15 11.03 1162 1534758 62628 108990751
Leukopenia 39.10 11.03 1678 1534242 147113 108906266
Headache 38.97 11.03 13241 1522679 869136 108184243
Blood glucose increased 38.50 11.03 1477 1534443 131019 108922360
General physical health deterioration 38.44 11.03 5247 1530673 420048 108633331
Cardiac disorder 38.21 11.03 788 1535132 75492 108977887
Specific gravity urine decreased 38.17 11.03 54 1535866 832 109052547
Acute myeloid leukaemia recurrent 37.98 11.03 12 1535908 5127 109048252
Chronic kidney disease 37.66 11.03 790 1535130 75501 108977878
Injection site rash 37.59 11.03 182 1535738 23237 109030142
Conjunctivitis allergic 37.56 11.03 25 1535895 6906 109046473
Brain oedema 37.52 11.03 624 1535296 30474 109022905
Dissociation 37.42 11.03 49 1535871 9793 109043586
Haematochezia 37.14 11.03 1272 1534648 114252 108939127
Acute graft versus host disease in intestine 36.91 11.03 16 1535904 5623 109047756
Acute kidney injury 36.91 11.03 9642 1526278 625788 108427591
Product administration error 36.87 11.03 724 1535196 36493 109016886
Drug abuser 36.85 11.03 161 1535759 5248 109048131
Accidental poisoning 36.67 11.03 96 1535824 2391 109050988
Clostridium test positive 36.54 11.03 268 1535652 10625 109042754
Anion gap increased 36.51 11.03 138 1535782 4206 109049173
Analgesic drug level above therapeutic 36.40 11.03 40 1535880 469 109052910
Incorrect dose administered by device 36.36 11.03 25 1535895 6789 109046590
Gastrointestinal toxicity 36.09 11.03 62 1535858 11086 109042293
Vascular stent thrombosis 36.02 11.03 7 1535913 4154 109049225
Gastric cancer 35.84 11.03 61 1535859 10947 109042432
Gamma-glutamyltransferase increased 35.80 11.03 1110 1534810 60199 108993180
Methaemoglobinaemia 35.73 11.03 234 1535686 8934 109044445
Seizure 35.23 11.03 2619 1533301 218566 108834813
Red blood cells urine positive 35.07 11.03 154 1535766 5031 109048348
Mycobacterial infection 35.07 11.03 9 1535911 4408 109048971
Complications of transplanted kidney 35.03 11.03 31 1535889 7411 109045968
Sphincter of Oddi dysfunction 34.95 11.03 42 1535878 546 109052833
Product substitution issue 34.86 11.03 183 1535737 22878 109030501
Pulmonary fibrosis 34.82 11.03 1115 1534805 100927 108952452
Analgesic therapy 34.70 11.03 30 1535890 7254 109046125
Muscle spasticity 34.68 11.03 696 1535224 35219 109018160
Needle issue 34.58 11.03 129 1535791 17711 109035668
Urine analysis abnormal 34.56 11.03 188 1535732 6709 109046670
Depression 34.53 11.03 3868 1532052 313467 108739912
Oedema peripheral 34.47 11.03 4016 1531904 324644 108728735
Lipodystrophy acquired 34.45 11.03 10 1535910 4514 109048865
Cytomegalovirus chorioretinitis 34.39 11.03 29 1535891 7099 109046280
Polyomavirus viraemia 34.29 11.03 4 1535916 3470 109049909
Cardiomyopathy 34.19 11.03 299 1535621 33226 109020153
Sedation complication 34.18 11.03 424 1535496 19431 109033948
Inspiratory capacity decreased 34.09 11.03 96 1535824 2499 109050880
Toxic anterior segment syndrome 34.03 11.03 4 1535916 3450 109049929
Human herpesvirus 6 infection 33.99 11.03 25 1535895 6556 109046823
Type I hypersensitivity 33.90 11.03 177 1535743 6216 109047163
Cryptococcosis 33.89 11.03 11 1535909 4620 109048759
Disturbance in social behaviour 33.67 11.03 14 1535906 5044 109048335
Transient ischaemic attack 33.53 11.03 656 1535264 63326 108990053
Specific gravity urine increased 33.39 11.03 39 1535881 491 109052888
Genital haemorrhage 33.19 11.03 31 1535889 7221 109046158
Varicella zoster virus infection 33.14 11.03 24 1535896 6344 109047035
Ductus arteriosus stenosis foetal 33.09 11.03 21 1535899 104 109053275
Abdominal pain upper 33.08 11.03 5425 1530495 343686 108709693
Hepatitis B reactivation 33.08 11.03 33 1535887 7451 109045928
Pulmonary arterial hypertension 32.98 11.03 291 1535629 32277 109021102
Blood urine present 32.84 11.03 496 1535424 23749 109029630
Hypocalcaemia 32.82 11.03 675 1535245 64691 108988688
Creatinine renal clearance decreased 32.60 11.03 454 1535466 21361 109032018
Dermatitis atopic 32.58 11.03 214 1535706 25327 109028052
Atrial fibrillation 32.57 11.03 2745 1533175 226897 108826482
Coronary arterial stent insertion 32.51 11.03 21 1535899 5894 109047485
Asphyxia 32.46 11.03 321 1535599 13894 109039485
Decreased appetite 32.36 11.03 5967 1529953 469879 108583500
Psoriatic arthropathy 32.27 11.03 2324 1533596 194437 108858942
Cardiac failure chronic 32.22 11.03 92 1535828 13719 109039660
Renal cortical necrosis 32.08 11.03 38 1535882 486 109052893
Dust allergy 32.04 11.03 22 1535898 5979 109047400
Maternal exposure during pregnancy 31.90 11.03 3076 1532844 251807 108801572
Progressive multifocal leukoencephalopathy 31.89 11.03 209 1535711 24747 109028632
Drug reaction with eosinophilia and systemic symptoms 31.86 11.03 1420 1534500 80675 108972704
Substance abuse 31.73 11.03 288 1535632 12175 109041204
Respiratory symptom 31.70 11.03 104 1535816 14841 109038538
Electric shock 31.63 11.03 75 1535845 1753 109051626
Status epilepticus 31.57 11.03 283 1535637 31288 109022091
Hepatic enzyme increased 31.48 11.03 4996 1530924 315896 108737483
Osteonecrosis of jaw 31.41 11.03 473 1535447 47544 109005835
Nephropathy toxic 31.26 11.03 238 1535682 27240 109026139
Red cell distribution width increased 31.21 11.03 378 1535542 17224 109036155
Infection reactivation 31.12 11.03 9 1535911 4072 109049307
Infusion site rash 31.10 11.03 87 1535833 2256 109051123
Torsade de pointes 31.08 11.03 185 1535735 22415 109030964
Systemic candida 30.91 11.03 57 1535863 9917 109043462
Inappropriate schedule of product administration 30.90 11.03 3256 1532664 200381 108852998
Sexual dysfunction 30.89 11.03 44 1535876 8486 109044893
Histoplasmosis disseminated 30.85 11.03 8 1535912 3891 109049488
Wrong patient received product 30.84 11.03 178 1535742 6496 109046883
Chest discomfort 30.81 11.03 2810 1533110 171038 108882341
Tardive dyskinesia 30.56 11.03 92 1535828 13487 109039892
Urine ketone body present 30.54 11.03 120 1535800 3726 109049653
Multiple organ dysfunction syndrome 30.33 11.03 1760 1534160 149950 108903429
Metastases to lymph nodes 30.26 11.03 107 1535813 14925 109038454
Ejection fraction 30.19 11.03 3 1535917 2952 109050427
Rheumatoid lung 30.16 11.03 11 1535909 4293 109049086
Mite allergy 30.03 11.03 22 1535898 5781 109047598
Product quality issue 30.01 11.03 830 1535090 76469 108976910
Product dose omission in error 29.99 11.03 197 1535723 23315 109030064
Ear pain 29.86 11.03 959 1534961 52267 109001112
Neoplasm malignant 29.72 11.03 351 1535569 36792 109016587
White blood cell count decreased 29.60 11.03 2762 1533158 226628 108826751
No adverse event 29.41 11.03 790 1535130 73049 108980330
Candida infection 29.36 11.03 479 1535441 47530 109005849
Inadequate analgesia 29.33 11.03 144 1535776 4933 109048446
Unmasking of previously unidentified disease 29.07 11.03 3 1535917 2865 109050514
Substance use disorder 29.07 11.03 35 1535885 7255 109046124
Pneumatosis intestinalis 28.95 11.03 46 1535874 8483 109044896
Drug tolerance 28.94 11.03 125 1535795 16460 109036919
Bacterial test 28.90 11.03 56 1535864 1133 109052246
Product preparation error 28.81 11.03 68 1535852 10811 109042568
Granulocytopenia 28.72 11.03 86 1535834 12629 109040750
Haemorrhage 28.70 11.03 1200 1534720 105492 108947887
Syncope 28.57 11.03 2422 1533498 200114 108853265
Dyspnoea 28.55 11.03 14450 1521470 1092422 107960957
Brain stem glioma 28.52 11.03 24 1535896 196 109053183
Metastases to bone 28.48 11.03 288 1535632 31084 109022295
Glutathione decreased 28.28 11.03 15 1535905 49 109053330
Systemic mycosis 28.19 11.03 9 1535911 3820 109049559
Incorrect drug administration rate 28.18 11.03 151 1535769 5357 109048022
Hypoprothrombinaemia 28.15 11.03 49 1535871 910 109052469
Stenotrophomonas infection 28.06 11.03 24 1535896 5834 109047545
Temperature regulation disorder 28.02 11.03 287 1535633 12539 109040840
Prostatic specific antigen increased 27.99 11.03 85 1535835 12426 109040953
Memory impairment 27.95 11.03 2354 1533566 194590 108858789
Enterococcal infection 27.86 11.03 167 1535753 20199 109033180
Haemoglobin urine present 27.85 11.03 48 1535872 884 109052495
Agranulocytosis 27.77 11.03 1085 1534835 60675 108992704
Lethargy 27.72 11.03 1577 1534343 91999 108961380
Oedematous pancreatitis 27.69 11.03 67 1535853 1587 109051792
Nodule 27.42 11.03 305 1535615 32326 109021053
Face oedema 27.31 11.03 633 1535287 32836 109020543
Gingival hypertrophy 27.24 11.03 13 1535907 4318 109049061
Hyperbilirubinaemia 27.20 11.03 587 1535333 30084 109023295
Upper gastrointestinal haemorrhage 27.17 11.03 899 1535021 49197 109004182
Drug screen positive 27.08 11.03 167 1535753 6243 109047136
Hepatic cirrhosis 27.07 11.03 723 1535197 66903 108986476
Stress cardiomyopathy 27.05 11.03 120 1535800 15686 109037693
Joint destruction 26.95 11.03 71 1535849 10872 109042507
Gallbladder injury 26.95 11.03 57 1535863 1231 109052148
Feeling cold 26.87 11.03 640 1535280 33347 109020032
Viral haemorrhagic cystitis 26.85 11.03 7 1535913 3392 109049987
Agitation 26.83 11.03 1869 1534051 111182 108942197
Feeling hot 26.72 11.03 1534 1534386 89572 108963807
Abortion spontaneous 26.65 11.03 326 1535594 33956 109019423
Skin toxicity 26.40 11.03 80 1535840 11703 109041676
Akathisia 26.32 11.03 135 1535785 16978 109036401
Retinal haemorrhage 26.28 11.03 58 1535862 9443 109043936
Culture urine positive 26.28 11.03 134 1535786 4662 109048717
Infusion site discomfort 26.17 11.03 70 1535850 1767 109051612
Blood bilirubin increased 26.04 11.03 1298 1534622 74674 108978705
Pulmonary nocardiosis 26.02 11.03 3 1535917 2626 109050753
Cytomegalovirus colitis 25.99 11.03 36 1535884 7025 109046354
Infusion site bruising 25.97 11.03 111 1535809 3583 109049796
Blood pH decreased 25.97 11.03 131 1535789 4538 109048841
Transplant failure 25.90 11.03 24 1535896 5611 109047768
Chronic graft versus host disease in skin 25.89 11.03 3 1535917 2616 109050763
Hyperprolactinaemia 25.76 11.03 32 1535888 6543 109046836
Symmetrical drug-related intertriginous and flexural exanthema 25.73 11.03 71 1535849 1826 109051553
Blood immunoglobulin E increased 25.73 11.03 40 1535880 7442 109045937
Cholelithiasis 25.71 11.03 1102 1534818 62320 108991059
Intraocular pressure increased 25.71 11.03 72 1535848 10804 109042575
Arteriosclerosis 25.65 11.03 220 1535700 24547 109028832
Epilepsy 25.52 11.03 1134 1534786 99075 108954304
Weight fluctuation 25.49 11.03 441 1535479 21704 109031675
Right ventricular failure 25.36 11.03 234 1535686 25720 109027659
Gene mutation 25.35 11.03 8 1535912 3421 109049958
Glucose-6-phosphate dehydrogenase deficiency 25.33 11.03 33 1535887 468 109052911
Sensitisation 25.29 11.03 13 1535907 4138 109049241
Acquired gene mutation 25.22 11.03 4 1535916 2750 109050629
Bronchial secretion retention 25.21 11.03 137 1535783 4887 109048492
Adulterated product 25.20 11.03 52 1535868 1103 109052276
Secondary immunodeficiency 25.16 11.03 17 1535903 4659 109048720
Dyspnoea at rest 24.73 11.03 49 1535871 8297 109045082
Obesity 24.68 11.03 1304 1534616 112047 108941332
Coagulation factor decreased 24.60 11.03 27 1535893 316 109053063
Meningitis aseptic 24.58 11.03 227 1535693 9643 109043736
Osmolar gap 24.38 11.03 20 1535900 157 109053222
Gait disturbance 24.33 11.03 3439 1532481 274769 108778610
Premature delivery 24.30 11.03 290 1535630 30342 109023037
Pulmonary tuberculosis 24.30 11.03 57 1535863 9082 109044297
Hypercalcaemia 24.26 11.03 479 1535441 46178 109007201
Self-medication 24.25 11.03 159 1535761 6073 109047306
Blood creatinine decreased 24.21 11.03 213 1535707 8924 109044455
COVID-19 treatment 24.19 11.03 31 1535889 432 109052947
Tenosynovitis 24.18 11.03 130 1535790 16153 109037226
Disseminated aspergillosis 24.12 11.03 3 1535917 2477 109050902
Hepatic cancer 24.10 11.03 77 1535843 11079 109042300
Drug eruption 24.09 11.03 564 1535356 53095 109000284
Hypertriglyceridaemia 23.97 11.03 129 1535791 16025 109037354
Nitrite urine present 23.95 11.03 53 1535867 1182 109052197
Cryopyrin associated periodic syndrome 23.89 11.03 36 1535884 589 109052790
Galactorrhoea 23.88 11.03 14 1535906 4141 109049238
Renal failure 23.82 11.03 2768 1533152 223806 108829573
Faeces discoloured 23.80 11.03 629 1535291 33319 109020060
Febrile neutropenia 23.78 11.03 4864 1531056 311903 108741476
Epstein-Barr viraemia 23.67 11.03 10 1535910 3569 109049810
Paraesthesia ear 23.63 11.03 33 1535887 502 109052877
Livedo reticularis 23.61 11.03 144 1535776 5362 109048017
Dose calculation error 23.58 11.03 30 1535890 415 109052964
Eyelid ptosis 23.53 11.03 100 1535820 13227 109040152
Neuroblastoma recurrent 23.39 11.03 33 1535887 507 109052872
Peritonitis bacterial 23.25 11.03 72 1535848 10461 109042918
Injection site discolouration 23.23 11.03 58 1535862 9045 109044334
Metabolic disorder 23.09 11.03 72 1535848 10438 109042941
Granuloma 23.05 11.03 62 1535858 9428 109043951
Anosognosia 23.03 11.03 14 1535906 4060 109049319
Mycobacterium chelonae infection 22.87 11.03 7 1535913 3053 109050326
Complication of device insertion 22.80 11.03 56 1535864 8782 109044597
Sleep disorder due to general medical condition, insomnia type 22.76 11.03 1733 1534187 103910 108949469
Impaired quality of life 22.75 11.03 287 1535633 29730 109023649
Bacterial test positive 22.74 11.03 189 1535731 7788 109045591
C-reactive protein abnormal 22.72 11.03 1523 1534397 128172 108925207
Acute graft versus host disease in liver 22.59 11.03 3 1535917 2356 109051023
Sudden infant death syndrome 22.52 11.03 26 1535894 323 109053056
Renal disorder 22.51 11.03 519 1535401 48960 109004419
Hepatitis B 22.45 11.03 64 1535856 9548 109043831
Intervertebral discitis 22.33 11.03 170 1535750 6820 109046559
Macular oedema 22.32 11.03 39 1535881 6927 109046452
Allergy test negative 22.29 11.03 28 1535892 382 109052997
Aplasia pure red cell 22.20 11.03 64 1535856 9514 109043865
Drug tolerance decreased 22.13 11.03 260 1535660 27280 109026099
Pleurothotonus 22.05 11.03 4 1535916 2494 109050885
Left ventricular dysfunction 22.02 11.03 214 1535706 23279 109030100
Pulmonary toxicity 21.98 11.03 150 1535770 17596 109035783
Vitritis 21.86 11.03 5 1535915 2648 109050731
Infusion site mass 21.80 11.03 63 1535857 1665 109051714
Hepatitis C 21.79 11.03 95 1535825 12478 109040901
Monocyte percentage increased 21.76 11.03 76 1535844 2227 109051152
Coagulation factor X level decreased 21.68 11.03 15 1535905 88 109053291
Visual impairment 21.67 11.03 1590 1534330 132838 108920541
Skin burning sensation 21.66 11.03 196 1535724 21629 109031750
Viral load increased 21.59 11.03 10 1535910 3380 109049999
Drug use disorder 21.56 11.03 362 1535558 17712 109035667
Prothrombin time abnormal 21.54 11.03 52 1535868 1230 109052149
Bilirubin urine present 21.51 11.03 25 1535895 313 109053066
Cardiac failure acute 21.46 11.03 222 1535698 23856 109029523
SJS-TEN overlap 21.44 11.03 66 1535854 1808 109051571
Alopecia 21.41 11.03 4608 1531312 360145 108693234
Device use issue 21.40 11.03 13 1535907 3771 109049608
Embolic stroke 21.32 11.03 57 1535863 8686 109044693
Biliary dyskinesia 21.26 11.03 78 1535842 2343 109051036
Anticipatory anxiety 21.16 11.03 51 1535869 1205 109052174
Skin ulcer 21.10 11.03 698 1535222 62947 108990432
Renal failure neonatal 21.07 11.03 14 1535906 76 109053303
Kussmaul respiration 21.06 11.03 29 1535891 435 109052944
Eye irritation 21.04 11.03 332 1535588 33120 109020259
Neonatal respiratory acidosis 21.02 11.03 13 1535907 61 109053318
Ill-defined disorder 20.92 11.03 2487 1533433 154366 108899013
Ductus arteriosus premature closure 20.92 11.03 15 1535905 94 109053285
Device deployment issue 20.90 11.03 17 1535903 4236 109049143
Psychotic symptom 20.89 11.03 14 1535906 3853 109049526
Accidental death 20.85 11.03 130 1535790 4879 109048500
Sputum culture positive 20.85 11.03 108 1535812 3781 109049598
Osteomyelitis 20.81 11.03 370 1535550 36230 109017149
Hypertensive crisis 20.80 11.03 227 1535693 24145 109029234
Cyanosis neonatal 20.70 11.03 13 1535907 63 109053316
Staphylococcal infection 20.69 11.03 778 1535142 69166 108984213
Serum sickness 20.68 11.03 118 1535802 4288 109049091
Blister 20.60 11.03 3525 1532395 223851 108829528
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.57 11.03 27 1535893 5390 109047989
Pseudomonas infection 20.48 11.03 268 1535652 27585 109025794
Hyperhidrosis 20.46 11.03 2934 1532986 184364 108869015
Dermatitis 20.41 11.03 268 1535652 27569 109025810
Full blood count decreased 20.38 11.03 318 1535602 31781 109021598
Pancreatic carcinoma 20.32 11.03 122 1535798 14750 109038629
Rhinalgia 20.30 11.03 108 1535812 3821 109049558
Polyarthritis 20.29 11.03 167 1535753 18796 109034583
White coat hypertension 20.27 11.03 52 1535868 1279 109052100
Polycystic ovaries 20.24 11.03 22 1535898 4774 109048605
Disseminated tuberculosis 20.21 11.03 25 1535895 5121 109048258
Hepatocellular carcinoma 20.10 11.03 70 1535850 9810 109043569
Vital capacity decreased 20.10 11.03 69 1535851 2004 109051375
Metastases to central nervous system 20.08 11.03 211 1535709 22606 109030773
Wheezing 20.04 11.03 3175 1532745 252055 108801324
Feeling abnormal 19.99 11.03 2200 1533720 178511 108874868
Catatonia 19.82 11.03 85 1535835 11215 109042164
Dizziness 19.78 11.03 9086 1526834 689107 108364272
Oropharyngeal discomfort 19.74 11.03 225 1535695 10102 109043277
Tuberculosis 19.72 11.03 155 1535765 17619 109035760
Mycobacterium avium complex infection 19.66 11.03 32 1535888 5845 109047534
Hyperglycaemia 19.65 11.03 973 1534947 84117 108969262
Pneumonia cytomegaloviral 19.61 11.03 42 1535878 6912 109046467
Electrolyte imbalance 19.60 11.03 379 1535541 36649 109016730
Granulocyte count decreased 19.38 11.03 16 1535904 3958 109049421
Polyneuropathy 19.37 11.03 320 1535600 31692 109021687
Intestinal haemorrhage 19.35 11.03 46 1535874 7295 109046084
Skin exfoliation 19.33 11.03 1007 1534913 86644 108966735
Erythema 19.31 11.03 4449 1531471 286998 108766381
Carotid artery occlusion 19.31 11.03 68 1535852 9497 109043882
Acute haemorrhagic oedema of infancy 19.29 11.03 11 1535909 43 109053336
Congestive cardiomyopathy 19.24 11.03 117 1535803 14102 109039277
Coronary artery bypass 19.20 11.03 34 1535886 6008 109047371
Body height below normal 19.14 11.03 3 1535917 2081 109051298
Parvovirus B19 infection 19.14 11.03 8 1535912 2873 109050506
Enterobacter infection 19.10 11.03 32 1535888 5779 109047600
Adenovirus infection 19.10 11.03 83 1535837 10911 109042468
Incorrect dosage administered 19.10 11.03 106 1535814 3812 109049567
Pancreatitis acute 19.07 11.03 1022 1534898 59252 108994127
Liver transplant 19.04 11.03 119 1535801 4470 109048909
Periportal oedema 18.84 11.03 17 1535903 154 109053225
Toxicologic test abnormal 18.81 11.03 50 1535870 1257 109052122
Hypomagnesaemia 18.65 11.03 668 1535252 59702 108993677
Hyperlipasaemia 18.51 11.03 54 1535866 1435 109051944
Histoplasmosis 18.36 11.03 9 1535911 2944 109050435
Bradycardia neonatal 18.31 11.03 13 1535907 80 109053299
Disseminated cryptococcosis 18.27 11.03 7 1535913 2650 109050729
Laboratory test abnormal 18.24 11.03 469 1535451 43610 109009769
Erythema annulare 18.19 11.03 22 1535898 288 109053091
Coma scale abnormal 18.19 11.03 211 1535709 9515 109043864
Hyperleukocytosis 18.09 11.03 95 1535825 3344 109050035
Nephrectomy 18.07 11.03 7 1535913 2633 109050746
Mania 18.02 11.03 193 1535727 20603 109032776
Device defective 17.89 11.03 16 1535904 3806 109049573
Erythema multiforme 17.83 11.03 401 1535519 20696 109032683
Sedation 17.77 11.03 1159 1534761 68524 108984855
Hyperlipidaemia 17.75 11.03 371 1535549 35477 109017902
Pulmonary mucormycosis 17.74 11.03 4 1535916 2139 109051240
Fibrin D dimer increased 17.71 11.03 212 1535708 9633 109043746
Pneumocystis jirovecii infection 17.68 11.03 21 1535899 4379 109049000
SARS-CoV-2 test positive 17.64 11.03 332 1535588 16603 109036776
Osteolysis 17.62 11.03 31 1535889 5492 109047887
Leukaemia 17.60 11.03 50 1535870 7468 109045911
Alpha tumour necrosis factor increased 17.59 11.03 25 1535895 387 109052992
Injury associated with device 17.58 11.03 21 1535899 4368 109049011
Hepatorenal failure 17.56 11.03 50 1535870 1310 109052069
Fear of injection 17.56 11.03 64 1535856 8847 109044532
Contraindicated product administered 17.49 11.03 3107 1532813 245160 108808219
Therapeutic product effect decreased 17.48 11.03 3055 1532865 241261 108812118
Chondrocalcinosis 17.47 11.03 64 1535856 1921 109051458
Bundle branch block left 17.46 11.03 106 1535814 12782 109040597
Foot deformity 17.45 11.03 526 1535394 47954 109005425
Food allergy 17.44 11.03 381 1535539 19567 109033812
C-reactive protein increased 17.42 11.03 2708 1533212 215211 108838168
Pruritus 17.37 11.03 8611 1527309 572949 108480430
Diffuse axonal injury 17.36 11.03 14 1535906 107 109053272
Epstein-Barr virus associated lymphoproliferative disorder 17.16 11.03 25 1535895 4777 109048602
Diffuse large B-cell lymphoma refractory 17.15 11.03 75 1535845 2446 109050933
Lung neoplasm malignant 17.13 11.03 349 1535571 33493 109019886
Muscle spasms 17.09 11.03 3506 1532414 274651 108778728
Eosinophilia 17.08 11.03 976 1534944 56960 108996419
Adverse event 17.06 11.03 1290 1534630 107519 108945860
Folliculitis 16.98 11.03 2615 1533305 165038 108888341
Squamous cell carcinoma 16.97 11.03 169 1535751 18294 109035085
Muscle injury 16.89 11.03 2218 1533702 138589 108914790
Foot operation 16.85 11.03 49 1535871 7264 109046115
Proteinuria 16.77 11.03 425 1535495 39593 109013786
Adrenal insufficiency 16.76 11.03 454 1535466 41936 109011443
Prostate cancer stage II 16.68 11.03 5 1535915 2210 109051169
Dehydration 16.60 11.03 3529 1532391 275982 108777397
Blood ethanol increased 16.58 11.03 31 1535889 610 109052769
Failure of child resistant product closure 16.52 11.03 11 1535909 60 109053319
Analgesic drug level therapeutic 16.45 11.03 5 1535915 0 109053379
Dyskinesia 16.41 11.03 567 1535353 50879 109002500
Gallbladder adenocarcinoma 16.39 11.03 14 1535906 117 109053262
Cardiovascular disorder 16.37 11.03 220 1535700 22540 109030839
Apparent death 16.37 11.03 10 1535910 2892 109050487
Schizophrenia 16.35 11.03 408 1535512 21418 109031961
Impaired work ability 16.35 11.03 263 1535657 26156 109027223
Hypomania 16.29 11.03 215 1535705 9995 109043384
Stent placement 16.29 11.03 49 1535871 7185 109046194
Leukoencephalopathy 16.23 11.03 69 1535851 9126 109044253
Sopor 16.16 11.03 385 1535535 36161 109017218
Hepatitis E 16.15 11.03 23 1535897 4436 109048943
Hyperaesthesia 16.14 11.03 291 1535629 14436 109038943
Type IIa hyperlipidaemia 16.14 11.03 27 1535893 485 109052894
Neoplasm recurrence 16.13 11.03 30 1535890 5202 109048177
Product tampering 16.09 11.03 26 1535894 453 109052926
Leukocyturia 16.08 11.03 69 1535851 2231 109051148
Viraemia 16.04 11.03 20 1535900 4082 109049297
Neurological symptom 16.01 11.03 139 1535781 15469 109037910
Fracture 15.93 11.03 245 1535675 24543 109028836
Therapy change 15.87 11.03 78 1535842 9919 109043460
Truncus coeliacus thrombosis 15.87 11.03 7 1535913 13 109053366
Growth retardation 15.86 11.03 8 1535912 2574 109050805
Toxoplasmosis 15.85 11.03 13 1535907 3226 109050153
Atypical mycobacterial infection 15.85 11.03 9 1535911 2709 109050670
Catheter site bruise 15.81 11.03 29 1535891 562 109052817
Postnatal growth restriction 15.81 11.03 8 1535912 23 109053356
Vascular purpura 15.78 11.03 98 1535822 3673 109049706
Toxic skin eruption 15.76 11.03 497 1535423 27018 109026361
Angina unstable 15.69 11.03 149 1535771 16283 109037096
Nipple inflammation 15.68 11.03 10 1535910 50 109053329
Klebsiella infection 15.66 11.03 190 1535730 19819 109033560
Loss of employment 15.66 11.03 14 1535906 3330 109050049
Paresis 15.63 11.03 27 1535893 4817 109048562
Periorbital oedema 15.59 11.03 213 1535707 9979 109043400
Ejection fraction abnormal 15.59 11.03 15 1535905 3445 109049934
Beta haemolytic streptococcal infection 15.58 11.03 82 1535838 2889 109050490
Irritable bowel syndrome 15.56 11.03 2552 1533368 161663 108891716
Gastrointestinal haemorrhage 15.53 11.03 2037 1533883 163481 108889898
Bone erosion 15.51 11.03 508 1535412 45863 109007516
Ischaemic cardiomyopathy 15.48 11.03 58 1535862 7953 109045426
Consciousness fluctuating 15.45 11.03 66 1535854 2130 109051249
Angina pectoris 15.44 11.03 707 1535213 61588 108991791
Immune-mediated myositis 15.34 11.03 40 1535880 6146 109047233
Scoliosis 15.25 11.03 187 1535733 8546 109044833
Lymphoma 15.23 11.03 193 1535727 19978 109033401
Monocyte chemotactic protein-1 increased 15.22 11.03 22 1535898 346 109053033
Corneal oedema 15.20 11.03 13 1535907 3160 109050219
Mucocutaneous disorder 15.17 11.03 17 1535903 204 109053175
Osmolar gap abnormal 15.16 11.03 12 1535908 89 109053290
Starvation ketoacidosis 15.16 11.03 21 1535899 317 109053062
Visceral leishmaniasis 15.10 11.03 3 1535917 1753 109051626
Post-traumatic stress disorder 15.09 11.03 149 1535771 6447 109046932
Aortic valve stenosis 15.04 11.03 42 1535878 6308 109047071
Fusarium infection 15.01 11.03 10 1535910 2761 109050618
Urine bilirubin decreased 15.00 11.03 14 1535906 133 109053246
Rash erythematous 15.00 11.03 1326 1534594 80506 108972873
Diplopia 14.96 11.03 455 1535465 41439 109011940
Concomitant disease aggravated 14.95 11.03 150 1535770 16214 109037165
Rhinorrhoea 14.93 11.03 1637 1534283 101029 108952350
Lyme disease 14.91 11.03 23 1535897 4293 109049086
Epstein-Barr virus infection reactivation 14.86 11.03 21 1535899 4063 109049316
Gallbladder disorder 14.85 11.03 390 1535530 20639 109032740
Arrhythmia 14.84 11.03 802 1535118 68773 108984606
Prescribed underdose 14.71 11.03 747 1535173 64427 108988952
Frostbite 14.71 11.03 19 1535901 267 109053112
Pleural thickening 14.64 11.03 89 1535831 3310 109050069
Skin cancer 14.64 11.03 167 1535753 17617 109035762
Dystonia 14.63 11.03 261 1535659 25544 109027835
Duodenal ulcer perforation 14.60 11.03 2741 1533179 174959 108878420
Cells in urine 14.60 11.03 16 1535904 187 109053192
Pancreatic fibrosis 14.55 11.03 12 1535908 95 109053284
Ataxia 14.50 11.03 313 1535607 29795 109023584
Mycobacterium abscessus infection 14.49 11.03 3 1535917 1703 109051676
Failure to suspend medication 14.48 11.03 25 1535895 461 109052918
Discoloured vomit 14.48 11.03 61 1535859 1956 109051423
pH urine increased 14.42 11.03 24 1535896 429 109052950
Acinetobacter infection 14.41 11.03 17 1535903 3556 109049823
PCO2 decreased 14.41 11.03 84 1535836 3077 109050302
Device breakage 14.40 11.03 122 1535798 13647 109039732
Cognitive disorder 14.38 11.03 1407 1534513 86104 108967275
Parkinsonism 14.36 11.03 219 1535701 21968 109031411
Pericardial haemorrhage 14.31 11.03 32 1535888 5185 109048194
Parvimonas micra infection 14.28 11.03 11 1535909 78 109053301
Rebound eczema 14.28 11.03 4 1535916 1848 109051531
Abortion induced 14.26 11.03 60 1535860 7959 109045420
Administration site bruise 14.26 11.03 17 1535903 219 109053160
Biliary sepsis 14.23 11.03 57 1535863 1786 109051593
Use of accessory respiratory muscles 14.19 11.03 31 1535889 685 109052694
Allodynia 14.19 11.03 62 1535858 2021 109051358
Neonatal respiratory distress syndrome 14.17 11.03 22 1535898 370 109053009
Delirium febrile 14.15 11.03 10 1535910 61 109053318
Colon cancer 14.09 11.03 153 1535767 16290 109037089
Disability 14.04 11.03 316 1535604 29907 109023472
Polydipsia 14.00 11.03 57 1535863 7631 109045748
Tachyarrhythmia 13.97 11.03 63 1535857 8198 109045181
Respiratory alkalosis 13.96 11.03 131 1535789 5590 109047789
Vascular graft 13.96 11.03 6 1535914 2119 109051260
Nephrogenic systemic fibrosis 13.94 11.03 35 1535885 5448 109047931
Pancreatic steatosis 13.93 11.03 4 1535916 1818 109051561
Eosinophil percentage increased 13.92 11.03 51 1535869 1531 109051848
Spontaneous haematoma 13.84 11.03 59 1535861 1902 109051477
Urobilinogen urine increased 13.84 11.03 29 1535891 622 109052757
Vulvar erosion 13.84 11.03 15 1535905 173 109053206
Complication of device removal 13.79 11.03 27 1535893 4593 109048786
Bronchospasm 13.77 11.03 532 1535388 29707 109023672
Plasma cell myeloma recurrent 13.60 11.03 51 1535869 6991 109046388
Fluid retention 13.55 11.03 1126 1534794 93181 108960198
Delusion 13.55 11.03 240 1535680 23515 109029864
Hypoglycaemic coma 13.55 11.03 36 1535884 5497 109047882
Nausea 13.53 11.03 17844 1518076 1217846 107835533
Migraine with aura 13.53 11.03 89 1535831 3403 109049976
Dependent personality disorder 13.53 11.03 12 1535908 106 109053273
Renal injury 13.42 11.03 181 1535739 18532 109034847
Cerebral haematoma 13.41 11.03 198 1535722 9434 109043945
Pleural effusion 13.36 11.03 2216 1533704 175493 108877886
Fungal rhinitis 13.35 11.03 11 1535909 87 109053292
Sleep terror 13.34 11.03 47 1535873 6563 109046816
Prothrombin level increased 13.32 11.03 26 1535894 529 109052850
Gestational diabetes 13.32 11.03 55 1535865 7334 109046045
Hyperprolinaemia 13.32 11.03 6 1535914 12 109053367
Febrile infection 13.28 11.03 26 1535894 4422 109048957
Contusion 13.24 11.03 3538 1532382 229823 108823556
Cardiac operation 13.22 11.03 41 1535879 5954 109047425
Tooth injury 13.19 11.03 64 1535856 2182 109051197
Acute lymphocytic leukaemia recurrent 13.17 11.03 39 1535881 5748 109047631
Strawberry tongue 13.17 11.03 7 1535913 23 109053356
Hepatitis non-A non-B 13.16 11.03 4 1535916 0 109053379
Procalcitonin increased 13.16 11.03 99 1535821 3957 109049422
Infusion site urticaria 13.15 11.03 42 1535878 1174 109052205
Haemolysis 13.14 11.03 297 1535623 15342 109038037
Erectile dysfunction 13.12 11.03 180 1535740 18376 109035003
B-cell lymphoma 13.05 11.03 53 1535867 7101 109046278
Acute promyelocytic leukaemia 13.03 11.03 5 1535915 1891 109051488
Transfusion-related circulatory overload 13.02 11.03 35 1535885 886 109052493
Band neutrophil percentage decreased 13.01 11.03 6 1535914 13 109053366
Immunisation 13.00 11.03 15 1535905 3168 109050211
Hyponatraemia 12.89 11.03 3306 1532614 214347 108839032
Acute fatty liver of pregnancy 12.86 11.03 8 1535912 38 109053341
Neovascularisation 12.84 11.03 53 1535867 1684 109051695
Focal dyscognitive seizures 12.84 11.03 21 1535899 3828 109049551
Ventricular hypokinesia 12.82 11.03 97 1535823 11117 109042262
Lip pruritus 12.82 11.03 44 1535876 1278 109052101
Pleural fibrosis 12.78 11.03 103 1535817 4205 109049174
Ankle arthroplasty 12.78 11.03 10 1535910 2541 109050838
Stoma site cellulitis 12.76 11.03 10 1535910 73 109053306
Nipple disorder 12.75 11.03 21 1535899 372 109053007
Cerebral haemorrhage 12.75 11.03 755 1535165 64213 108989166
Testicular infarction 12.72 11.03 9 1535911 55 109053324
Respiratory tract infection bacterial 12.71 11.03 9 1535911 2407 109050972
N-terminal prohormone brain natriuretic peptide increased 12.70 11.03 43 1535877 6078 109047301
Hallucination 12.70 11.03 1602 1534318 99830 108953549
Tongue disorder 12.67 11.03 132 1535788 14166 109039213
Paradoxical drug reaction 12.65 11.03 82 1535838 9735 109043644
Dermatitis bullous 12.64 11.03 326 1535594 17203 109036176
White blood cells urine 12.57 11.03 24 1535896 480 109052899
Ureaplasma infection 12.57 11.03 3 1535917 1543 109051836
Suspected suicide attempt 12.56 11.03 20 1535900 344 109053035
Catheterisation cardiac 12.51 11.03 44 1535876 6147 109047232
COVID-19 12.50 11.03 3699 1532221 241361 108812018
Liver transplant rejection 12.49 11.03 22 1535898 3896 109049483
Lung transplant 12.49 11.03 35 1535885 5251 109048128
Haemophagocytic lymphohistiocytosis 12.47 11.03 338 1535582 31221 109022158
Blindness 12.47 11.03 397 1535523 35962 109017417
Breast cancer 12.47 11.03 424 1535496 38118 109015261
Mycoplasma test positive 12.45 11.03 17 1535903 253 109053126
Allergic transfusion reaction 12.43 11.03 16 1535904 224 109053155
Meningitis cryptococcal 12.42 11.03 30 1535890 4732 109048647
Cardiospasm 12.40 11.03 32 1535888 4935 109048444
Limb mass 12.38 11.03 96 1535824 3873 109049506
Cardiac tamponade 12.36 11.03 99 1535821 11208 109042171
Mean cell haemoglobin concentration decreased 12.35 11.03 127 1535793 5555 109047824
Suspected COVID-19 12.33 11.03 87 1535833 3406 109049973
Leukocytosis 12.27 11.03 887 1535033 52941 109000438
Glucose tolerance impaired 12.26 11.03 83 1535837 9754 109043625
Glutathione synthetase deficiency 12.23 11.03 9 1535911 59 109053320
Rhinocerebral mucormycosis 12.22 11.03 3 1535917 1514 109051865
Long QT syndrome 12.21 11.03 54 1535866 7064 109046315
Jaundice neonatal 12.20 11.03 15 1535905 200 109053179
Eye pruritus 12.19 11.03 354 1535566 32421 109020958
Gastrooesophageal reflux disease 12.19 11.03 2257 1533663 177719 108875660
Postoperative delirium 12.17 11.03 34 1535886 881 109052498
Bacterial disease carrier 12.16 11.03 63 1535857 2206 109051173
Choluria 12.15 11.03 23 1535897 457 109052922
Administration site swelling 12.15 11.03 27 1535893 604 109052775
Hypervolaemia 12.12 11.03 562 1535358 48898 109004481
Pericardial effusion 12.12 11.03 660 1535260 56557 108996822
Adrenergic syndrome 12.11 11.03 17 1535903 260 109053119
Malabsorption 12.10 11.03 47 1535873 6378 109047001
Hypercholesterolaemia 12.10 11.03 1091 1534829 89746 108963633
Type 2 diabetes mellitus 12.07 11.03 2222 1533698 175010 108878369
Complication associated with device 12.03 11.03 201 1535719 19872 109033507
Tendonitis 12.03 11.03 273 1535647 25810 109027569
Vitamin K deficiency 12.03 11.03 34 1535886 887 109052492
Noninfective encephalitis 11.98 11.03 29 1535891 687 109052692
Haemoptysis 11.98 11.03 841 1535079 70513 108982866
Drug provocation test 11.97 11.03 7 1535913 29 109053350
Congenital central hypoventilation syndrome 11.97 11.03 7 1535913 29 109053350
Nasal septum perforation 11.96 11.03 34 1535886 890 109052489
Blood folate decreased 11.94 11.03 64 1535856 2271 109051108
Urine bilirubin increased 11.93 11.03 12 1535908 126 109053253
Alveolar rhabdomyosarcoma 11.92 11.03 6 1535914 17 109053362
Catheter management 11.88 11.03 21 1535899 3714 109049665
Coronary artery occlusion 11.88 11.03 151 1535769 15621 109037758
Brain natriuretic peptide increased 11.86 11.03 99 1535821 11110 109042269
Gynaecomastia 11.86 11.03 80 1535840 9410 109043969
IgA nephropathy 11.86 11.03 16 1535904 3157 109050222
Abdominal discomfort 11.83 11.03 5115 1530805 388743 108664636
Sensitivity to weather change 11.82 11.03 86 1535834 9942 109043437
Cholesterosis 11.81 11.03 20 1535900 363 109053016
Haematuria 11.79 11.03 992 1534928 82013 108971366
Hypertonia 11.79 11.03 173 1535747 8233 109045146
Anisocytosis 11.76 11.03 40 1535880 1156 109052223
Specific gravity urine abnormal 11.76 11.03 10 1535910 83 109053296
Respiratory acidosis 11.75 11.03 263 1535657 13563 109039816
Neutropenic sepsis 11.75 11.03 531 1535389 30215 109023164
Blood triglycerides increased 11.73 11.03 248 1535672 23678 109029701
Abnormal dreams 11.73 11.03 117 1535803 12663 109040716
Metastasis 11.73 11.03 67 1535853 8200 109045179
Alpha 1 microglobulin increased 11.69 11.03 8 1535912 46 109053333
Nutritional supplementation 11.69 11.03 8 1535912 46 109053333
Musculoskeletal disorder 11.69 11.03 233 1535687 22431 109030948
Prothrombin level decreased 11.67 11.03 53 1535867 1757 109051622
Triple negative breast cancer 11.66 11.03 24 1535896 508 109052871
Mitral valve incompetence 11.65 11.03 363 1535557 32966 109020413
Presbyacusis 11.63 11.03 73 1535847 2746 109050633
Rhabdomyolysis 11.63 11.03 1479 1534441 118922 108934457
Pneumonia fungal 11.58 11.03 140 1535780 14614 109038765
Alcoholic coma 11.57 11.03 10 1535910 85 109053294
Cerebral aspergillosis 11.56 11.03 9 1535911 2293 109051086
Myocardial ischaemia 11.56 11.03 282 1535638 26402 109026977
Injection site nodule 11.55 11.03 30 1535890 4616 109048763
Red blood cell sedimentation rate increased 11.54 11.03 933 1534987 77369 108976010
Metastases to skin 11.53 11.03 9 1535911 2290 109051089
Autonomic dysreflexia 11.52 11.03 23 1535897 476 109052903
Sepsis 11.52 11.03 4227 1531693 323119 108730260
Pregnancy with contraceptive device 11.52 11.03 23 1535897 3884 109049495
Peritoneal dialysis complication 11.52 11.03 11 1535909 2535 109050844
Herpes zoster 11.52 11.03 1323 1534597 107056 108946323
Loss of libido 11.51 11.03 16 1535904 3117 109050262
Electrocardiogram QT prolonged 11.46 11.03 1331 1534589 107629 108945750
Amniotic cavity disorder 11.42 11.03 8 1535912 48 109053331
Neuropathy, ataxia, retinitis pigmentosa syndrome 11.42 11.03 8 1535912 48 109053331
Secretion discharge 11.40 11.03 205 1535715 20039 109033340
Lupus vasculitis 11.40 11.03 26 1535894 592 109052787
Alcohol use 11.40 11.03 97 1535823 4025 109049354
Vein collapse 11.39 11.03 42 1535878 1265 109052114
Mixed dementia 11.38 11.03 17 1535903 276 109053103
Lupus-like syndrome 11.35 11.03 457 1535463 40335 109013044
Injection site irritation 11.34 11.03 33 1535887 4891 109048488
Drug level increased 11.33 11.03 789 1535131 46930 109006449
Balance disorder 11.33 11.03 1814 1534106 114746 108938633
Electrocardiogram abnormal 11.33 11.03 187 1535733 18522 109034857
Vaccination site swelling 11.30 11.03 8 1535912 49 109053330
Anal ulcer 11.24 11.03 6 1535914 1870 109051509
Anti-erythrocyte antibody positive 11.24 11.03 9 1535911 68 109053311
Infection masked 11.23 11.03 12 1535908 136 109053243
Hypotonic-hyporesponsive episode 11.22 11.03 6 1535914 20 109053359
Calciphylaxis 11.22 11.03 26 1535894 4161 109049218
Acute respiratory failure 11.21 11.03 896 1535024 74364 108979015
Transferrin decreased 11.17 11.03 24 1535896 524 109052855
Breast cancer stage IV 11.16 11.03 7 1535913 1996 109051383
Tri-iodothyronine free increased 11.15 11.03 16 1535904 250 109053129
Reversible airways obstruction 11.13 11.03 66 1535854 2433 109050946
Subacute cutaneous lupus erythematosus 11.12 11.03 34 1535886 4960 109048419
Prostatic pain 11.11 11.03 17 1535903 282 109053097
Macrophages increased 11.10 11.03 16 1535904 251 109053128
Low density lipoprotein decreased 11.10 11.03 3 1535917 1419 109051960
Lip swelling 11.05 11.03 832 1535088 49835 109003544
Eyelid oedema 11.05 11.03 284 1535636 14978 109038401
Skin disorder 11.05 11.03 485 1535435 42428 109010951

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental overdose 41.47 15.03 23 1118 127 112685
Analgesic drug level increased 25.05 15.03 9 1132 12 112800
Overdose 19.89 15.03 11 1130 60 112752
Drug level increased 17.45 15.03 10 1131 59 112753
Incorrect dosage administered 15.23 15.03 6 1135 12 112800

Pharmacologic Action:

SourceCodeDescription
ATC N02AJ01 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ06 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ13 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ17 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ22 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02BE01 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Anilides
ATC N02BE51 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Anilides
ATC N02BE71 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Anilides
MeSH PA D000700 Analgesics
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D058633 Antipyretics
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35493 antipyretic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50629 cyclooxygenase 2 inhibitor
CHEBI has role CHEBI:50630 cyclooxygenase 1 inhibitor
CHEBI has role CHEBI:50908 hepatotoxic agent
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64951 anti-HBV agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73263 cyclooxygenase 3 inhibitor
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:85234 human blood serum metabolite
CHEBI has role CHEBI:173085 ferroptosis inducer
CHEBI has role CHEBI:176497 geroprotector
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

N02AJ Opioids in combination with non-opioid analgesics 9 drugs
acetylsalicylic acidcelecoxibcodeinedexketoprofendihydrocodeinehydrocodoneibuprofenoxycodonetramadol
N02BE Anilides 3 drugs
bucetinphenacetinpropacetamol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Pain indication 22253000
Toothache indication 27355003
Migraine indication 37796009 DOID:6364
Joint pain indication 57676002
Allergic rhinitis indication 61582004
Common cold indication 82272006 DOID:10459
Backache indication 161891005
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Fever indication 386661006
Tension-type headache indication 398057008
Arthritic Pain indication
Pain Treatment Adjunct indication
Vascular headache off-label use 128187005
Fibromyalgia off-label use 203082005 DOID:631
Hepatic encephalopathy contraindication 13920009 DOID:13413
Cirrhosis of liver contraindication 19943007 DOID:5082
Hepatic failure contraindication 59927004
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.69 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 7976870 June 1, 2027 METHOD OF TREATING PATIENTS WITH GASTRIC RETENTIVE DOSAGE FORM
1GM/100ML (10MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** OFIRMEV MALLINCKRODT HOSP N022450 Nov. 2, 2010 DISCN SOLUTION INTRAVENOUS 10383834 Nov. 13, 2028 MODIFIED DOSING REGIMEN FOR THE MANAGEMENT OF MILD TO MODERATE PAIN
1GM/100ML (10MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** OFIRMEV MALLINCKRODT HOSP N022450 Nov. 2, 2010 DISCN SOLUTION INTRAVENOUS 10383834 Nov. 13, 2028 MODIFIED DOSING REGIMEN FOR THE REDUCTION OF FEVER
1GM/100ML (10MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** OFIRMEV MALLINCKRODT HOSP N022450 Nov. 2, 2010 DISCN SOLUTION INTRAVENOUS 9610265 Nov. 13, 2028 MODIFIED DOSING REGIMEN FOR THE MANAGEMENT OF MODERATE TO SEVERE PAIN WITH ADJUNCTIVE OPIOID ANALGESICS
1GM/100ML (10MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** OFIRMEV MALLINCKRODT HOSP N022450 Nov. 2, 2010 DISCN SOLUTION INTRAVENOUS 9987238 Nov. 13, 2028 MODIFIED DOSING REGIMEN FOR THE MANAGEMENT OF MILD TO MODERATE PAIN OR MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 8372432 March 11, 2029 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 8668929 March 11, 2029 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 8377453 Nov. 19, 2029 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
325MG;EQ 4.08MG BASE APADAZ ZEVRA THERAP N208653 Jan. 4, 2019 DISCN TABLET ORAL 9132125 July 1, 2030 MANAGEMENT OF ACUTE PAIN SEVERE ENOUGH TO REQUIRE AN OPIOID ANALGESIC AND FOR WHICH ALTERNATIVE TREATMENTS ARE INADEQUATE
325MG;EQ 6.12MG BASE APADAZ ZEVRA THERAP N208653 Feb. 23, 2018 DISCN TABLET ORAL 9132125 July 1, 2030 MANAGEMENT OF ACUTE PAIN SEVERE ENOUGH TO REQUIRE AN OPIOID ANALGESIC AND FOR WHICH ALTERNATIVE TREATMENTS ARE INADEQUATE
325MG;EQ 8.16MG BASE APADAZ ZEVRA THERAP N208653 Jan. 4, 2019 DISCN TABLET ORAL 9132125 July 1, 2030 MANAGEMENT OF ACUTE PAIN SEVERE ENOUGH TO REQUIRE AN OPIOID ANALGESIC AND FOR WHICH ALTERNATIVE TREATMENTS ARE INADEQUATE
1GM/100ML (10MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** OFIRMEV MALLINCKRODT HOSP N022450 Nov. 2, 2010 DISCN SOLUTION INTRAVENOUS 9399012 Sept. 11, 2031 MODIFIED DOSING REGIMEN FOR THE MANAGEMENT OF MILD TO MODERATE PAIN OR MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS
1GM/100ML (10MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** OFIRMEV MALLINCKRODT HOSP N022450 Nov. 2, 2010 DISCN SOLUTION INTRAVENOUS 9399012 Sept. 11, 2031 MODIFIED DOSING REGIMEN FOR THE REDUCTION OF FEVER
1GM/100ML (10MG/ML);EQ 300MG BASE/100ML (EQ 3MG BASE/ML) COMBOGESIC IV HIKMA N215320 Oct. 17, 2023 RX SOLUTION INTRAVENOUS 11446266 Oct. 26, 2031 METHOD OF TREATING MILD TO MODERATE PAIN IN ADULTS
1GM/100ML (10MG/ML);EQ 300MG BASE/100ML (EQ 3MG BASE/ML) COMBOGESIC IV HIKMA N215320 Oct. 17, 2023 RX SOLUTION INTRAVENOUS 11446266 Oct. 26, 2031 METHOD OF TREATING MODERATE TO SEVERE PAIN IN ADULTS AS AN ADJUNCT TO OPIOID ANALGESICS
1GM/100ML (10MG/ML);EQ 300MG BASE/100ML (EQ 3MG BASE/ML) COMBOGESIC IV HIKMA N215320 Oct. 17, 2023 RX SOLUTION INTRAVENOUS 11896567 Oct. 26, 2031 METHOD OF TREATING MILD TO MODERATE PAIN IN ADULTS
1GM/100ML (10MG/ML);EQ 300MG BASE/100ML (EQ 3MG BASE/ML) COMBOGESIC IV HIKMA N215320 Oct. 17, 2023 RX SOLUTION INTRAVENOUS 11896567 Oct. 26, 2031 METHOD OF TREATING MODERATE TO SEVERE PAIN IN ADULTS AS AN ADJUNCT TO OPIOID ANALGESICS
1GM/100ML (10MG/ML);EQ 300MG BASE/100ML (EQ 3MG BASE/ML) COMBOGESIC IV HIKMA N215320 Oct. 17, 2023 RX SOLUTION INTRAVENOUS 12220392 Oct. 26, 2031 METHOD OF TREATING MILD TO MODERATE PAIN (SURGICAL) IN ADULTS
1GM/100ML (10MG/ML);EQ 300MG BASE/100ML (EQ 3MG BASE/ML) COMBOGESIC IV HIKMA N215320 Oct. 17, 2023 RX SOLUTION INTRAVENOUS 12220392 Oct. 26, 2031 METHOD OF TREATING MODERATE TO SEVERE PAIN (SURGICAL) IN ADULTS AS AN ADJUNCT TO OPIOID ANALGESICS
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 8741885 May 16, 2032 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 9468636 May 16, 2032 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
1GM/100ML (10MG/ML);EQ 300MG BASE/100ML (EQ 3MG BASE/ML) COMBOGESIC IV HIKMA N215320 Oct. 17, 2023 RX SOLUTION INTRAVENOUS 12083087 July 17, 2035 METHOD OF TREATING MILD TO MODERATE PAIN IN ADULTS
1GM/100ML (10MG/ML);EQ 300MG BASE/100ML (EQ 3MG BASE/ML) COMBOGESIC IV HIKMA N215320 Oct. 17, 2023 RX SOLUTION INTRAVENOUS 12083087 July 17, 2035 METHOD OF TREATING MODERATE TO SEVERE PAIN IN ADULTS AS AN ADJUNCT TO OPIOID ANALGESICS
325MG;97.5MG COMBOGESIC AFT PHARMS US N209471 March 1, 2023 RX TABLET ORAL 11197830 Feb. 27, 2039 A METHOD OF TREATING MILD TO MODERATE ACUTE PAIN IN ADULTS BY ADMINISTERING 975-1000 MG OF ACETAMINOPHEN AND 292.5-300 MG OF IBUPROFEN IN A SINGLE ADMINISTRATION
325MG;97.5MG COMBOGESIC AFT PHARMS US N209471 March 1, 2023 RX TABLET ORAL 11534407 Feb. 27, 2039 A METHOD OF TREATING MILD TO MODERATE ACUTE PAIN IN ADULTS BY ADMINISTERING 975-1000 MG OF ACETAMINOPHEN AND 292.5-300 MG OF IBUPROFEN IN A SINGLE ADMINISTRATION

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
650MG/65ML (10MG/ML) ACETAMINOPHEN BAXTER HLTHCARE CORP A214331 May 21, 2025 RX SOLUTION INTRAVENOUS Jan. 7, 2026 PATENT CHALLENGE
325MG;97.5MG COMBOGESIC AFT PHARMS US N209471 March 1, 2023 RX TABLET ORAL March 1, 2026 NEW PRODUCT
1GM/100ML (10MG/ML);EQ 300MG BASE/100ML (EQ 3MG BASE/ML) COMBOGESIC IV HIKMA N215320 Oct. 17, 2023 RX SOLUTION INTRAVENOUS Oct. 17, 2026 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 4.31 WOMBAT-PK CHEMBL
Transient receptor potential cation channel subfamily V member 1 Ion channel OPENER WOMBAT-PK CHEMBL
Cannabinoid receptor 1 GPCR AGONIST WOMBAT-PK SCIENTIFIC LITERATURE
Carbonic anhydrase 2 Enzyme Ki 5.21 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 4.94 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.15 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.39 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 5.04 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.15 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 4.97 CHEMBL
Arachidonate 5-lipoxygenase-activating protein Cytosolic other IC50 4.36 CHEMBL
Transient receptor potential cation channel subfamily V member 4 Ion channel INHIBITOR IC50 6.52 IUPHAR
Myoglobin Cytosolic other IC50 5.64 CHEMBL
Transient receptor potential cation channel subfamily V member 4 Ion channel INHIBITOR IC50 6.52 IUPHAR
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
Arachidonate 15-lipoxygenase Enzyme IC50 4.55 DRUG MATRIX
Carbonic anhydrase 13 Enzyme Ki 4.52 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 5.03 CHEMBL

External reference:

IDSource
4017513 VUID
N0000145898 NUI
D00217 KEGG_DRUG
161 RXNORM
C0000970 UMLSCUI
CHEBI:46195 CHEBI
NNS PDB_CHEM_ID
CHEMBL112 ChEMBL_ID
DB00316 DRUGBANK_ID
5239 IUPHAR_LIGAND_ID
1983 PUBCHEM_CID
4119 MMSL
4973 MMSL
4992 MMSL
5005 MMSL
52845 MMSL
97317 MMSL
d00049 MMSL
D000082 MESH_DESCRIPTOR_UI
626 INN_ID
4017513 VANDF
362O9ITL9D UNII
001605 NDDF
387517004 SNOMEDCT_US
90332006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Robitussin Maximum Strength Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 3 0031-0100 LIQUID 650 mg ORAL OTC Monograph Drug 16 sections
Robitussin Maximum Strength Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 2 0031-0101 LIQUID 650 mg ORAL OTC Monograph Drug 17 sections
Robitussin Maximum Strength Severe Multi-Symptom 7 in 1 Relief Nighttime HUMAN OTC DRUG LABEL 3 0031-8744 CAPSULE, LIQUID FILLED 325 mg ORAL OTC Monograph Drug 17 sections
Robitussin Maximum Strength Severe Cough Plus Sore Throat HUMAN OTC DRUG LABEL 2 0031-8750 LIQUID 650 mg ORAL OTC Monograph Drug 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 4 0031-8751 LIQUID 650 mg ORAL OTC Monograph Drug 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 3 0031-8752 SOLUTION 650 mg ORAL OTC Monograph Drug 17 sections
Robitussin Honey Severe Cough, Flu Plus Sore Throat Nighttime HUMAN OTC DRUG LABEL 2 0031-8770 SOLUTION 650 mg ORAL OTC Monograph Drug 17 sections
Robitussin Honey Severe Cough, Flu Plus Sore Throat HUMAN OTC DRUG LABEL 2 0031-8771 SOLUTION 650 mg ORAL OTC Monograph Drug 17 sections
Robitussin Direct Sore Throat Pain HUMAN OTC DRUG LABEL 1 0031-9301 TABLET, COATED 500 mg ORAL OTC Monograph Drug 15 sections
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0054-0650 CAPSULE 300 mg ORAL ANDA 33 sections
HYDROCODONE BITARTRATE AND ACETAMINOPHEN HUMAN PRESCRIPTION DRUG LABEL 2 0054-0843 LIQUID 300 mg ORAL ANDA 31 sections
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0054-3000 CAPSULE 325 mg ORAL ANDA 33 sections
Theraflu Severe Cold Relief Daytime HUMAN OTC DRUG LABEL 2 0067-0100 POWDER, FOR SOLUTION 500 mg ORAL OTC Monograph Drug 16 sections
Theraflu Severe Cold Relief Nighttime HUMAN OTC DRUG LABEL 2 0067-0101 POWDER, FOR SOLUTION 650 mg ORAL OTC Monograph Drug 17 sections
Theraflu Severe Cold Relief Daytime Honey Ginger HUMAN OTC DRUG LABEL 2 0067-0103 POWDER, FOR SOLUTION 650 mg ORAL OTC Monograph Drug 16 sections
Theraflu Severe Cold Relief Chest Congestion Daytime HUMAN OTC DRUG LABEL 3 0067-0104 SYRUP 650 mg ORAL OTC Monograph Drug 15 sections
Theraflu Severe Cold Relief Nighttime HUMAN OTC DRUG LABEL 2 0067-0105 SYRUP 650 mg ORAL OTC Monograph Drug 16 sections
Theraflu Severe Cold Relief Daytime Berry Burst HUMAN OTC DRUG LABEL 2 0067-0106 POWDER, FOR SOLUTION 650 mg ORAL OTC Monograph Drug 16 sections
TherafluSevere Cold Relief Soft Chews HUMAN OTC DRUG LABEL 2 0067-0111 TABLET, CHEWABLE 325 mg ORAL OTC Monograph Drug 15 sections
Theraflu Severe Cold Relief Nighttime Soft Chews HUMAN OTC DRUG LABEL 2 0067-0112 TABLET, CHEWABLE 325 mg ORAL OTC Monograph Drug 16 sections
Theraflu-D Flu Relief Max Strength plus Nasal Decongestant Nighttime HUMAN OTC DRUG LABEL 4 0067-0114 SYRUP 1000 mg ORAL OTC Monograph Drug 17 sections
Theraflu-D Flu Relief Max Strength plus Nasal Decongestant HUMAN OTC DRUG LABEL 3 0067-0115 SYRUP 1000 mg ORAL OTC Monograph Drug 17 sections
TheraFlu Cold and Flu HUMAN OTC DRUG LABEL 3 0067-0924 POWDER 325 mg ORAL Export only 10 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 13 sections
Excedrin Extra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 15 sections
Excedrin Extra Strength Headache HUMAN OTC DRUG LABEL 3 0067-2002 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 15 sections
Excedrin Extra Strength Headache HUMAN OTC DRUG LABEL 3 0067-2003 TABLET, FILM COATED 250 mg ORAL OTC Monograph Drug 15 sections
ExcedrinExtra Strength Geltabs HUMAN OTC DRUG LABEL 3 0067-2021 TABLET, COATED 250 mg ORAL OTC Monograph Drug 14 sections
Excedrin Migraine Geltabs HUMAN OTC DRUG LABEL 3 0067-2035 TABLET, COATED 250 mg ORAL NDA 14 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 250 mg ORAL NDA 15 sections