ramipril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 2356 87333-19-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • HOE498
  • HOE-498
  • ramipril
A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.
  • Molecular weight: 416.52
  • Formula: C23H32N2O5
  • CLOGP: 1.54
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -4.03
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.69 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 28 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 28, 1991 FDA KING PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 2113.70 35.87 639 4983 27483 2324980
Hyperkalaemia 1439.80 35.87 342 5280 5551 2346912
Hypotension 1327.81 35.87 467 5155 31969 2320494
Hyponatraemia 1075.31 35.87 322 5300 13003 2339460
Fall 844.21 35.87 374 5248 46725 2305738
Angioedema 812.57 35.87 234 5388 8162 2344301
Drug interaction 636.86 35.87 267 5355 28896 2323567
Bradycardia 591.70 35.87 191 5431 9790 2342673
Confusional state 558.27 35.87 231 5391 24113 2328350
Dehydration 550.15 35.87 223 5399 22072 2330391
Orthostatic hypotension 517.33 35.87 131 5491 2748 2349715
Dizziness 505.50 35.87 284 5338 58381 2294082
Vomiting 470.82 35.87 291 5331 71311 2281152
Lactic acidosis 454.85 35.87 135 5487 5195 2347268
Syncope 440.62 35.87 176 5446 16699 2335764
Asthenia 383.87 35.87 220 5402 46706 2305757
Cough 355.56 35.87 186 5436 32931 2319532
Nausea 329.85 35.87 280 5342 111909 2240554
Dyspnoea 324.54 35.87 240 5382 78493 2273970
Swollen tongue 319.04 35.87 103 5519 5240 2347223
Diarrhoea 313.98 35.87 241 5381 83323 2269140
Blood pressure increased 305.33 35.87 136 5486 16850 2335613
Cardiac failure 263.56 35.87 111 5511 11983 2340480
Hypertension 249.32 35.87 138 5484 27223 2325240
Malaise 247.77 35.87 178 5444 55407 2297056
Toxicity to various agents 247.05 35.87 146 5476 32608 2319855
Chest pain 245.71 35.87 138 5484 27999 2324464
Renal failure 234.21 35.87 114 5508 17235 2335228
Renal impairment 227.76 35.87 95 5527 9997 2342466
Blood creatinine increased 223.84 35.87 95 5527 10438 2342025
Patent ductus arteriosus 210.58 35.87 48 5574 626 2351837
Circulatory collapse 194.84 35.87 65 5557 3655 2348808
Presyncope 193.44 35.87 65 5557 3738 2348725
Intentional overdose 191.55 35.87 87 5535 11234 2341229
Drug hypersensitivity 190.84 35.87 142 5480 46501 2305962
Drug intolerance 187.61 35.87 91 5531 13626 2338837
Sopor 182.50 35.87 63 5559 3932 2348531
Electrolyte imbalance 179.60 35.87 53 5569 1984 2350479
Atrial septal defect 177.67 35.87 48 5574 1296 2351167
General physical health deterioration 176.07 35.87 88 5534 14051 2338412
Condition aggravated 171.61 35.87 115 5507 31864 2320599
Overdose 169.10 35.87 96 5526 19811 2332652
Hypokalaemia 168.06 35.87 78 5544 10576 2341887
Headache 167.60 35.87 166 5456 80013 2272450
Premature delivery 159.97 35.87 54 5568 3146 2349317
Somnolence 159.48 35.87 98 5524 23387 2329076
Hypertensive crisis 156.20 35.87 50 5572 2463 2350000
Oedema peripheral 155.88 35.87 97 5525 23666 2328797
Lip swelling 149.07 35.87 57 5565 4764 2347699
Intentional self-injury 146.54 35.87 54 5568 4073 2348390
Decreased appetite 140.93 35.87 98 5524 28793 2323670
Asphyxia 138.07 35.87 37 5585 967 2351496
Anaphylactic reaction 137.49 35.87 66 5556 9639 2342824
Loss of consciousness 136.83 35.87 82 5540 18685 2333778
Ischaemic stroke 133.83 35.87 48 5574 3349 2349114
Rhabdomyolysis 130.89 35.87 57 5565 6647 2345816
Tongue oedema 129.63 35.87 34 5588 816 2351647
Palpitations 125.41 35.87 74 5548 16382 2336081
Swelling face 120.79 35.87 60 5562 9433 2343030
Foetal exposure during pregnancy 120.23 35.87 50 5572 5202 2347261
Suicide attempt 119.47 35.87 63 5559 11219 2341244
Hypoglycaemia 118.54 35.87 57 5565 8350 2344113
Dysmorphism 116.36 35.87 27 5595 382 2352081
Maternal exposure during pregnancy 116.30 35.87 68 5554 14795 2337668
Agitation 115.00 35.87 61 5561 10990 2341473
Jaundice 108.05 35.87 47 5575 5461 2347002
Erythema 108.00 35.87 79 5543 25080 2327383
Exposure during pregnancy 107.83 35.87 79 5543 25140 2327323
Pruritus 107.81 35.87 99 5523 43241 2309222
Renin increased 105.66 35.87 18 5604 39 2352424
Arteriosclerosis coronary artery 105.46 35.87 31 5591 1142 2351321
Shock 101.45 35.87 41 5581 3963 2348500
Abdominal pain upper 100.78 35.87 72 5550 22028 2330435
Blood sodium decreased 100.65 35.87 38 5584 3062 2349401
Rash 100.18 35.87 110 5512 59448 2293015
Tachycardia 100.01 35.87 64 5558 16345 2336118
Anuria 99.96 35.87 33 5589 1791 2350672
Limb reduction defect 99.80 35.87 18 5604 61 2352402
Drug abuse 99.31 35.87 57 5565 11969 2340494
Blister 98.76 35.87 47 5575 6724 2345739
Labelled drug-drug interaction medication error 97.86 35.87 30 5592 1278 2351185
Inappropriate antidiuretic hormone secretion 96.13 35.87 34 5588 2275 2350188
Premature baby 95.85 35.87 37 5585 3167 2349296
Drug ineffective 93.59 35.87 139 5483 101485 2250978
Dysphagia 93.38 35.87 56 5566 12749 2339714
Restlessness 92.97 35.87 40 5582 4523 2347940
Drug reaction with eosinophilia and systemic symptoms 91.93 35.87 42 5580 5476 2346987
Tinnitus 91.62 35.87 41 5581 5094 2347369
Toxic epidermal necrolysis 89.42 35.87 35 5587 3109 2349354
Coma scale abnormal 88.63 35.87 25 5597 793 2351670
Cardiac arrest 87.93 35.87 57 5565 14873 2337590
Fatigue 86.69 35.87 122 5500 84751 2267712
Product prescribing error 80.84 35.87 32 5590 2928 2349535
Blood potassium increased 78.90 35.87 29 5593 2167 2350296
Renal artery stenosis 77.87 35.87 18 5604 250 2352213
Glomerular filtration rate decreased 77.76 35.87 26 5596 1467 2350996
Atrial fibrillation 77.24 35.87 51 5571 13717 2338746
Rash pruritic 76.68 35.87 41 5581 7494 2344969
Metabolic acidosis 76.52 35.87 38 5584 5960 2346503
Stoma site haemorrhage 75.34 35.87 15 5607 96 2352367
Disorientation 74.34 35.87 38 5584 6334 2346129
Dermatitis exfoliative 74.25 35.87 24 5598 1217 2351246
Labile hypertension 74.10 35.87 14 5608 65 2352398
Transient ischaemic attack 73.68 35.87 37 5585 5941 2346522
Vertigo 73.52 35.87 43 5579 9341 2343122
Contusion 73.19 35.87 48 5574 12762 2339701
Abdominal pain 72.97 35.87 72 5550 34302 2318161
Medication error 72.80 35.87 37 5585 6094 2346369
Cholelithiasis 71.77 35.87 36 5586 5767 2346696
Respiratory disorder 71.51 35.87 32 5590 3972 2348491
Pneumonia 70.84 35.87 84 5538 49212 2303251
Chest discomfort 69.83 35.87 49 5573 14546 2337917
Discomfort 69.73 35.87 34 5588 5125 2347338
Orthostatic intolerance 68.96 35.87 15 5607 155 2352308
Dysarthria 68.96 35.87 36 5586 6266 2346197
Lower respiratory tract infection 68.11 35.87 34 5588 5390 2347073
Hepatocellular injury 67.95 35.87 31 5591 4024 2348439
Obstructive airways disorder 67.91 35.87 23 5599 1350 2351113
Multiple organ dysfunction syndrome 67.85 35.87 38 5584 7603 2344860
Caesarean section 67.77 35.87 31 5591 4050 2348413
Contraindicated product administered 66.55 35.87 28 5594 2993 2349470
Congenital choroid plexus cyst 66.01 35.87 12 5610 43 2352420
Hypoaesthesia 65.98 35.87 54 5568 20161 2332302
Hyperthyroidism 65.51 35.87 25 5597 2072 2350391
Myalgia 65.21 35.87 57 5565 23276 2329187
Blood urea increased 64.98 35.87 29 5593 3576 2348887
Gait disturbance 64.87 35.87 56 5566 22489 2329974
Electrocardiogram QT prolonged 64.37 35.87 37 5585 7777 2344686
Cholestasis 64.10 35.87 29 5593 3692 2348771
Cleft palate 63.94 35.87 15 5607 223 2352240
Retrognathia 63.82 35.87 12 5610 54 2352409
Depression 63.56 35.87 61 5561 28071 2324392
Stevens-Johnson syndrome 63.41 35.87 30 5592 4229 2348234
Delirium 63.40 35.87 32 5590 5191 2347272
Blood pressure abnormal 63.04 35.87 23 5599 1682 2350781
Hyperhidrosis 62.89 35.87 47 5575 15375 2337088
Arrhythmia 61.88 35.87 33 5589 5995 2346468
Urine output decreased 61.82 35.87 22 5600 1497 2350966
Product monitoring error 61.49 35.87 13 5609 116 2352347
Talipes 61.15 35.87 15 5607 272 2352191
Tension 60.42 35.87 17 5605 534 2351929
Cholecystitis 60.40 35.87 24 5598 2216 2350247
Thrombocytosis 59.86 35.87 19 5603 908 2351555
Weight decreased 59.38 35.87 59 5563 28312 2324151
Limb hypoplasia congenital 59.24 35.87 10 5612 20 2352443
Muscle spasms 58.89 35.87 52 5570 21514 2330949
Anal incontinence 58.52 35.87 22 5600 1750 2350713
Ejection fraction decreased 58.51 35.87 25 5597 2776 2349687
International normalised ratio increased 58.47 35.87 34 5588 7302 2345161
Lethargy 58.02 35.87 36 5586 8694 2343769
Cardiogenic shock 57.94 35.87 24 5598 2467 2349996
Paraesthesia 57.81 35.87 52 5570 22036 2330427
Speech disorder 56.99 35.87 32 5590 6432 2346031
Pharyngeal oedema 56.32 35.87 26 5596 3467 2348996
Basilar artery thrombosis 56.12 35.87 10 5612 31 2352432
Vision blurred 56.04 35.87 43 5579 14625 2337838
Haematoma 55.30 35.87 29 5593 5092 2347371
Eczema 55.27 35.87 25 5597 3180 2349283
Myocardial infarction 54.22 35.87 47 5575 18966 2333497
Congenital oral malformation 53.31 35.87 9 5613 18 2352445
Acidosis 53.20 35.87 20 5602 1590 2350873
Liver injury 52.82 35.87 22 5600 2292 2350171
Anaemia 52.77 35.87 61 5561 34731 2317732
Chronic kidney disease 52.24 35.87 26 5596 4092 2348371
Depressed level of consciousness 52.16 35.87 32 5590 7572 2344891
Wheezing 51.97 35.87 30 5592 6354 2346109
Constipation 50.92 35.87 48 5574 21581 2330882
Pemphigoid 50.73 35.87 17 5605 965 2351498
Eosinophilia 50.69 35.87 23 5599 2947 2349516
Agranulocytosis 50.22 35.87 24 5598 3458 2349005
Pulmonary fibrosis 50.03 35.87 22 5600 2618 2349845
Hypertelorism of orbit 49.96 35.87 10 5612 66 2352397
Cerebrovascular accident 49.84 35.87 46 5576 20140 2332323
Ventricular septal defect 49.78 35.87 16 5606 796 2351667
Hypersensitivity 49.23 35.87 49 5573 23544 2328919
Blood pressure decreased 48.85 35.87 33 5589 9203 2343260
Abnormal clotting factor 48.14 35.87 9 5613 39 2352424
Sciatica 47.82 35.87 20 5602 2105 2350358
Placental insufficiency 47.52 35.87 12 5610 246 2352217
Feeling abnormal 47.41 35.87 48 5574 23533 2328930
Balance disorder 47.24 35.87 33 5589 9714 2342749
Atrioventricular block 47.16 35.87 17 5605 1200 2351263
Hypophagia 47.06 35.87 24 5598 3976 2348487
Muscular weakness 46.92 35.87 39 5583 14858 2337605
Hepatitis acute 46.87 35.87 18 5604 1517 2350946
Dysphonia 46.79 35.87 28 5594 6336 2346127
Rheumatoid arthritis 46.06 35.87 43 5579 19097 2333366
Developmental hip dysplasia 46.01 35.87 11 5611 178 2352285
Blood pressure systolic increased 45.97 35.87 20 5602 2319 2350144
Insomnia 45.59 35.87 49 5573 25738 2326725
Hand deformity 45.22 35.87 16 5606 1070 2351393
Treatment noncompliance 45.02 35.87 26 5596 5508 2346955
Hypertensive angiopathy 44.82 35.87 7 5615 6 2352457
Aplasia 44.34 35.87 13 5609 474 2351989
Pyrexia 44.32 35.87 70 5552 53638 2298825
Mitral valve incompetence 44.31 35.87 20 5602 2530 2349933
Haemoglobin decreased 44.10 35.87 41 5581 18110 2334353
Brain stem stroke 44.01 35.87 9 5613 67 2352396
Transaminases increased 43.97 35.87 24 5598 4563 2347900
Poisoning deliberate 43.78 35.87 16 5606 1175 2351288
Sleep disorder 43.72 35.87 27 5595 6462 2346001
Neck deformity 43.33 35.87 9 5613 73 2352390
Mobility decreased 43.10 35.87 30 5592 8780 2343683
Mucosal dryness 43.07 35.87 12 5610 363 2352100
HELLP syndrome 43.00 35.87 11 5611 238 2352225
Vitiligo 42.78 35.87 11 5611 243 2352220
Alanine aminotransferase increased 42.67 35.87 36 5586 13996 2338467
Laryngeal oedema 42.56 35.87 16 5606 1272 2351191
Oliguria 41.75 35.87 16 5606 1341 2351122
Visual impairment 41.72 35.87 33 5589 11722 2340741
Troponin increased 41.61 35.87 15 5607 1059 2351404
Low birth weight baby 41.44 35.87 14 5608 815 2351648
Blood creatine phosphokinase increased 41.44 35.87 24 5598 5112 2347351
Angina pectoris 41.40 35.87 22 5600 3965 2348498
Cutaneous lupus erythematosus 41.30 35.87 13 5609 604 2351859
Urticaria 40.96 35.87 45 5577 24216 2328247
Dry mouth 40.13 35.87 28 5594 8225 2344238
Cerebral ischaemia 40.11 35.87 15 5607 1175 2351288
C-reactive protein increased 39.55 35.87 25 5597 6230 2346233
Tooth injury 39.46 35.87 10 5612 208 2352255
Oligohydramnios 39.43 35.87 14 5608 946 2351517
Atrioventricular block first degree 39.33 35.87 14 5608 953 2351510
Anxiety 38.78 35.87 48 5574 29311 2323152
Accidental overdose 38.67 35.87 21 5601 3951 2348512
Hepatic enzyme increased 38.00 35.87 29 5593 9773 2342690
Atrioventricular block complete 37.60 35.87 15 5607 1399 2351064
Subacute cutaneous lupus erythematosus 37.54 35.87 11 5611 400 2352063
Lip oedema 37.20 35.87 13 5609 838 2351625
Pallor 37.03 35.87 20 5602 3722 2348741
Deep vein thrombosis 36.91 35.87 32 5590 12900 2339563
Wound 36.91 35.87 18 5604 2710 2349753
Skin exfoliation 36.26 35.87 23 5599 5767 2346696
Suspiciousness 36.24 35.87 8 5614 89 2352374
Euphoric mood 36.19 35.87 13 5609 908 2351555
Abnormal loss of weight 35.95 35.87 12 5610 673 2351790

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 2613.52 31.77 905 5149 34039 1706688
Hypotension 1314.79 31.77 528 5526 29126 1711601
Hyperkalaemia 1203.73 31.77 362 5692 8185 1732542
Angioedema 928.43 31.77 306 5748 9358 1731369
Syncope 737.79 31.77 285 5769 13884 1726843
Fall 722.36 31.77 339 5715 26875 1713852
Dehydration 597.37 31.77 261 5793 17397 1723330
Dizziness 548.49 31.77 304 5750 34057 1706670
Bradycardia 540.55 31.77 210 5844 10324 1730403
Drug interaction 531.57 31.77 278 5776 27680 1713047
Dyspnoea 516.25 31.77 339 5715 51720 1689007
Cough 470.46 31.77 227 5827 18970 1721757
Hyponatraemia 435.16 31.77 172 5882 8828 1731899
Orthostatic hypotension 353.56 31.77 115 5939 3316 1737411
Loss of consciousness 340.09 31.77 168 5886 14707 1726020
Swollen tongue 338.21 31.77 106 5948 2702 1738025
Overdose 293.29 31.77 158 5896 16543 1724184
Presyncope 284.23 31.77 92 5962 2606 1738121
Blood creatinine increased 273.25 31.77 142 5912 13804 1726923
Product prescribing error 261.27 31.77 84 5970 2326 1738401
Confusional state 249.97 31.77 155 5899 21123 1719604
Chest pain 246.48 31.77 150 5904 19764 1720963
General physical health deterioration 224.18 31.77 122 5932 12996 1727731
Asthenia 219.99 31.77 173 5881 34497 1706230
Somnolence 219.72 31.77 131 5923 16608 1724119
Lactic acidosis 216.27 31.77 89 5965 5040 1735687
Renal failure 212.91 31.77 137 5917 19880 1720847
Malaise 212.64 31.77 159 5895 29406 1711321
Blood pressure increased 209.02 31.77 109 5945 10644 1730083
Intentional overdose 194.02 31.77 93 5961 7577 1733150
Lip swelling 191.20 31.77 69 5985 2726 1738001
Cardiac failure 190.08 31.77 108 5946 12494 1728233
Atrial fibrillation 182.07 31.77 112 5942 14999 1725728
Hypertension 179.78 31.77 122 5932 19326 1721401
Metabolic acidosis 166.07 31.77 75 5979 5327 1735400
Wound 165.00 31.77 54 6000 1580 1739147
Tongue oedema 163.25 31.77 43 6011 571 1740156
Sopor 161.99 31.77 56 5998 1945 1738782
Foetal exposure during pregnancy 160.45 31.77 77 5977 6282 1734445
Atrial septal defect 153.94 31.77 49 6005 1309 1739418
Hypertensive crisis 152.31 31.77 50 6004 1477 1739250
Diarrhoea 146.20 31.77 168 5886 53684 1687043
Condition aggravated 136.91 31.77 107 5947 21043 1719684
Vomiting 134.46 31.77 137 5917 38178 1702549
Toxicity to various agents 130.09 31.77 119 5935 29022 1711705
Hypoglycaemia 128.94 31.77 73 5981 8365 1732362
Oedema peripheral 128.18 31.77 91 5963 15459 1725268
Oliguria 126.65 31.77 41 6013 1157 1739570
Shock 122.25 31.77 56 5998 4105 1736622
Circulatory collapse 122.16 31.77 53 6001 3414 1737313
Renal impairment 120.20 31.77 80 5974 12234 1728493
Cholestasis 116.13 31.77 52 6002 3613 1737114
Pharyngeal oedema 113.71 31.77 41 6013 1612 1739115
Lethargy 109.32 31.77 62 5992 7122 1733605
Arrhythmia 108.26 31.77 58 5996 5958 1734769
Pruritus 107.80 31.77 97 5957 23125 1717602
Swelling face 106.13 31.77 52 6002 4431 1736296
Patent ductus arteriosus 104.53 31.77 31 6023 648 1740079
Balance disorder 104.49 31.77 56 5998 5756 1734971
Suicide attempt 102.44 31.77 60 5994 7321 1733406
Nausea 102.16 31.77 137 5917 51059 1689668
Cardiogenic shock 101.35 31.77 42 6012 2412 1738315
Intentional self-injury 97.88 31.77 42 6012 2631 1738096
Fatigue 96.91 31.77 133 5921 50648 1690079
Lichenoid keratosis 96.62 31.77 26 6028 376 1740351
International normalised ratio increased 95.94 31.77 60 5994 8239 1732488
Heart rate decreased 95.88 31.77 42 6012 2767 1737960
Drug ineffective 95.57 31.77 149 5905 63652 1677075
Anaemia 95.38 31.77 101 5953 29356 1711371
Vertigo 95.02 31.77 48 6006 4365 1736362
Hypokalaemia 94.25 31.77 54 6000 6320 1734407
Rhabdomyolysis 93.86 31.77 66 5988 11024 1729703
Naevus flammeus 93.04 31.77 17 6037 28 1740699
Premature baby 90.82 31.77 41 6013 2901 1737826
Erythema 89.99 31.77 71 5983 14117 1726610
Speech disorder 87.90 31.77 46 6008 4502 1736225
Blood potassium increased 86.90 31.77 38 6016 2492 1738235
Drug abuse 85.73 31.77 68 5986 13621 1727106
Poisoning deliberate 85.67 31.77 28 6026 814 1739913
Anuria 83.70 31.77 34 6020 1854 1738873
Depressed mood 83.60 31.77 39 6015 2977 1737750
Foetal disorder 83.49 31.77 17 6037 62 1740665
Actinic keratosis 82.74 31.77 25 6029 558 1740169
Contraindicated product administered 81.59 31.77 31 6023 1413 1739314
Eczema 80.12 31.77 35 6019 2289 1738438
Asthma 79.12 31.77 44 6010 4860 1735867
Shone complex 78.19 31.77 13 6041 7 1740720
Blood sodium decreased 77.17 31.77 34 6020 2270 1738457
Gout 76.15 31.77 35 6019 2581 1738146
Pyrexia 75.88 31.77 113 5941 46287 1694440
Ventricular septal defect 75.64 31.77 25 6029 753 1739974
Eosinophilia 74.86 31.77 38 6016 3489 1737238
Headache 74.61 31.77 96 5958 34280 1706447
Neutropenia neonatal 73.30 31.77 14 6040 33 1740694
Tachycardia 73.27 31.77 60 5994 12568 1728159
Haematuria 71.01 31.77 48 6006 7512 1733215
Lung disorder 69.38 31.77 41 6013 5078 1735649
Depression 68.28 31.77 65 5989 16604 1724123
Cranial sutures widening 67.48 31.77 11 6043 4 1740723
Gamma-glutamyltransferase increased 66.92 31.77 40 6014 5058 1735669
Nephroangiosclerosis 66.56 31.77 13 6041 36 1740691
Paralysis 65.64 31.77 26 6028 1326 1739401
Hyperhidrosis 65.53 31.77 56 5998 12432 1728295
Jaundice 65.46 31.77 42 6012 6020 1734707
Rash erythematous 65.11 31.77 36 6018 3929 1736798
Tricuspid valve incompetence 64.14 31.77 25 6029 1221 1739506
Oropharyngeal pain 63.76 31.77 38 6016 4780 1735947
Palpitations 63.36 31.77 43 6011 6771 1733956
Large for dates baby 63.35 31.77 15 6039 124 1740603
Precancerous skin lesion 62.22 31.77 15 6039 135 1740592
Aorta hypoplasia 61.77 31.77 12 6042 32 1740695
Basilar artery thrombosis 60.98 31.77 12 6042 35 1740692
Diabetic foetopathy 60.63 31.77 11 6043 17 1740710
Bowen's disease 59.96 31.77 17 6037 301 1740426
Angina pectoris 59.77 31.77 37 6017 4981 1735746
Cardiac failure chronic 59.72 31.77 20 6034 628 1740099
Chronic kidney disease 59.61 31.77 35 6019 4282 1736445
Medication error 59.12 31.77 36 6018 4707 1736020
Pallor 58.85 31.77 32 6022 3379 1737348
Throat tightness 58.07 31.77 25 6029 1577 1739150
Laryngeal oedema 57.05 31.77 21 6033 875 1739852
Fallot's tetralogy 56.39 31.77 14 6040 144 1740583
Coma 56.29 31.77 41 6013 7221 1733506
Supravalvular aortic stenosis 56.20 31.77 9 6045 2 1740725
Ejection fraction decreased 55.98 31.77 27 6027 2218 1738509
Inflammation 55.76 31.77 31 6023 3419 1737308
Diabetes mellitus inadequate control 54.72 31.77 25 6029 1817 1738910
Epiglottic oedema 54.47 31.77 12 6042 69 1740658
Renal tubular necrosis 54.40 31.77 26 6028 2093 1738634
Mouth breathing 54.26 31.77 11 6043 39 1740688
Interstitial lung disease 53.98 31.77 45 6009 9651 1731076
Glomerular filtration rate decreased 53.67 31.77 23 6031 1434 1739293
Salivary hypersecretion 53.55 31.77 23 6031 1442 1739285
Swelling 53.10 31.77 39 6015 6957 1733770
Myalgia 52.90 31.77 55 5999 15603 1725124
Oesophageal perforation 52.87 31.77 13 6041 128 1740599
Product monitoring error 52.44 31.77 12 6042 84 1740643
Agranulocytosis 52.04 31.77 30 6024 3546 1737181
Face oedema 52.00 31.77 26 6028 2310 1738417
Macrophages increased 51.77 31.77 9 6045 9 1740718
Weight decreased 51.59 31.77 65 5989 22688 1718039
Gait disturbance 51.08 31.77 49 6005 12621 1728106
Pain 50.92 31.77 70 5984 26587 1714140
Dysarthria 50.83 31.77 34 6020 5225 1735502
Blood pressure decreased 50.01 31.77 39 6015 7607 1733120
Actinic elastosis 49.97 31.77 9 6045 13 1740714
Musculoskeletal pain 49.51 31.77 33 6021 5041 1735686
Cold sweat 49.43 31.77 23 6031 1743 1738984
Melanoderma 49.21 31.77 10 6044 36 1740691
Blood creatine phosphokinase increased 49.08 31.77 41 6013 8815 1731912
Drug hypersensitivity 49.05 31.77 52 6002 15083 1725644
Paraesthesia oral 48.80 31.77 18 6036 754 1739973
Raynaud's phenomenon 47.80 31.77 15 6039 381 1740346
Pulmonary fibrosis 47.43 31.77 25 6029 2479 1738248
Mitral valve hypoplasia 47.08 31.77 8 6046 6 1740721
Agitation 47.03 31.77 44 6010 10982 1729745
Atrioventricular block complete 46.97 31.77 21 6033 1450 1739277
Haematoma 46.75 31.77 29 6025 3916 1736811
Hepatocellular injury 46.73 31.77 27 6027 3204 1737523
Coarctation of the aorta 46.72 31.77 12 6042 143 1740584
Oral neoplasm 46.60 31.77 9 6045 23 1740704
Abdominal pain 46.51 31.77 60 5994 21430 1719297
Discomfort 46.22 31.77 25 6029 2611 1738116
Hepatitis cholestatic 45.86 31.77 20 6034 1301 1739426
Erectile dysfunction 45.70 31.77 30 6024 4467 1736260
Palatal oedema 45.39 31.77 13 6041 239 1740488
Hypersensitivity 45.17 31.77 42 6012 10402 1730325
Chest discomfort 44.95 31.77 36 6018 7295 1733432
Aortic valve stenosis 44.55 31.77 13 6041 256 1740471
Vertebral osteophyte 43.47 31.77 8 6046 14 1740713
Arteriosclerotic gangrene 43.35 31.77 7 6047 2 1740725
Fracture displacement 43.12 31.77 8 6046 15 1740712
Wheezing 42.92 31.77 28 6026 4125 1736602
Low birth weight baby 42.85 31.77 17 6037 870 1739857
Cardiac septal hypertrophy 42.77 31.77 9 6045 40 1740687
Pemphigoid 41.90 31.77 18 6036 1129 1739598
Proteinuria 41.75 31.77 24 6030 2820 1737907
Memory impairment 41.44 31.77 33 6021 6630 1734097
Mitral valve incompetence 41.41 31.77 21 6033 1921 1738806
Hallucination, visual 41.09 31.77 23 6031 2569 1738158
Therapy non-responder 41.05 31.77 32 6022 6234 1734493
Product administration error 40.91 31.77 24 6030 2929 1737798
Ventricular dysfunction 40.90 31.77 15 6039 618 1740109
Skin exfoliation 40.68 31.77 28 6026 4507 1736220
Haemoglobin decreased 40.54 31.77 50 6004 17064 1723663
Inappropriate antidiuretic hormone secretion 40.51 31.77 20 6034 1728 1738999
Head injury 40.38 31.77 24 6030 3000 1737727
Dysphagia 40.36 31.77 39 6015 10129 1730598
Toxic epidermal necrolysis 40.22 31.77 22 6032 2349 1738378
Drug withdrawal convulsions 39.70 31.77 12 6042 268 1740459
Hypophagia 39.66 31.77 25 6029 3472 1737255
Dermatitis exfoliative 39.60 31.77 19 6035 1542 1739185
Dysphonia 39.28 31.77 25 6029 3530 1737197
Completed suicide 39.19 31.77 48 6006 16264 1724463
Hemiplegia 39.17 31.77 18 6036 1325 1739402
Vasoplegia syndrome 38.99 31.77 11 6043 191 1740536
Cardiac arrest 38.47 31.77 47 6007 15883 1724844
Muscle spasms 37.76 31.77 40 6014 11581 1729146
Pulmonary oedema 37.54 31.77 31 6023 6555 1734172
Lower respiratory tract infection 37.45 31.77 25 6029 3826 1736901
Chronotropic incompetence 37.43 31.77 7 6047 14 1740713
Blood urea increased 37.41 31.77 27 6027 4684 1736043
Bronchospasm 37.21 31.77 20 6034 2062 1738665
Intervertebral disc displacement 37.08 31.77 8 6046 41 1740686
Laryngeal cleft 36.94 31.77 6 6048 2 1740725
Vision blurred 36.66 31.77 34 6020 8389 1732338
Congenital heart valve disorder 36.50 31.77 7 6047 17 1740710
Renal artery stenosis 36.37 31.77 11 6043 246 1740481
Petechiae 36.33 31.77 18 6036 1567 1739160
Alcohol poisoning 36.32 31.77 13 6041 499 1740228
C-reactive protein increased 36.28 31.77 29 6025 5856 1734871
Pancreatitis acute 36.10 31.77 25 6029 4062 1736665
Oedema 36.09 31.77 31 6023 6917 1733810
Musculoskeletal chest pain 35.98 31.77 17 6037 1333 1739394
Lymphadenopathy 35.95 31.77 25 6029 4089 1736638
Rash maculo-papular 35.92 31.77 24 6030 3679 1737048
Hypoaesthesia 35.83 31.77 36 6018 9799 1730928
Stress 35.37 31.77 21 6033 2620 1738107
Nephrotic syndrome 35.21 31.77 17 6037 1399 1739328
Immune thrombocytopenic purpura 35.06 31.77 17 6037 1412 1739315
Hirsutism 34.95 31.77 8 6046 56 1740671
Acute hepatic failure 34.77 31.77 19 6035 2024 1738703
Mouth ulceration 34.59 31.77 18 6036 1737 1738990
Hypercholesterolaemia 34.58 31.77 16 6038 1196 1739531
Arterial intramural haematoma 34.51 31.77 6 6048 6 1740721
Intervertebral disc space narrowing 34.36 31.77 8 6046 61 1740666
Serotonin syndrome 34.31 31.77 21 6033 2767 1737960
Illusion 34.31 31.77 10 6044 196 1740531
Drooling 34.28 31.77 14 6040 773 1739954
Blood ethanol increased 34.13 31.77 8 6046 63 1740664
Blood pressure inadequately controlled 34.04 31.77 13 6041 600 1740127
Lip oedema 34.04 31.77 13 6041 600 1740127
Resuscitation 33.87 31.77 11 6043 313 1740414
Arteriosclerosis 33.73 31.77 18 6036 1829 1738898
Anaphylactoid reaction 33.66 31.77 13 6041 619 1740108
Squamous cell carcinoma 33.51 31.77 18 6036 1853 1738874
Rectal haemorrhage 33.51 31.77 27 6027 5515 1735212
Congenital aortic anomaly 33.47 31.77 7 6047 30 1740697
Polyuria 33.40 31.77 16 6038 1294 1739433
Inguinal hernia 33.19 31.77 15 6039 1062 1739665
Carcinogenicity 33.17 31.77 6 6048 9 1740718
Body temperature decreased 33.16 31.77 15 6039 1064 1739663
Decreased appetite 33.11 31.77 54 6000 23817 1716910
Oesophageal discomfort 32.76 31.77 7 6047 34 1740693
Crepitations 32.75 31.77 12 6042 493 1740234
Heart disease congenital 32.58 31.77 11 6043 354 1740373
Hyperthermia 32.35 31.77 17 6037 1674 1739053
Oedema mouth 32.23 31.77 11 6043 366 1740361
Dialysis 31.89 31.77 19 6035 2385 1738342

Pharmacologic Action:

SourceCodeDescription
ATC C09AA05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
ATC C09BB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX17 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
FDA EPC N0000175562 Angiotensin Converting Enzyme Inhibitor
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:77307 cardioprotective agent
CHEBI has role CHEBI:35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Cerebrovascular accident indication 230690007
Left ventricular cardiac dysfunction indication 429589006
Myocardial Infarction Prevention indication
Atrial fibrillation off-label use 49436004 DOID:0060224
Diabetic renal disease off-label use 127013003
Acute scleroderma renal crisis off-label use 236503001
Diastolic heart failure off-label use 418304008 DOID:9775
Hypertension due to Scleroderma off-label use
Nondiabetic Proteinuric Nephropathy off-label use
Hyperkalemia contraindication 14140009
Acute vomiting contraindication 23971007
Dehydration contraindication 34095006
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Oliguria contraindication 83128009
Systemic sclerosis contraindication 89155008 DOID:418
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Hyposensitization to allergens contraindication 182678001
Disease of liver contraindication 235856003 DOID:409
Renal dialysis contraindication 265764009
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Severe diarrhea contraindication 409587002
Azotemia contraindication 445009001
Head and Neck Angioedema contraindication
Intestinal Angioedema contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.21 acidic
pKa2 5.77 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1.25MG ALTACE KING PHARMS LLC N019901 Jan. 28, 1991 RX CAPSULE ORAL 7368469 Aug. 30, 2020 METHOD OF REDUCING RISK OF MYOCARDIAL INFARCTION, STROKE AND DEATH
10MG ALTACE KING PHARMS LLC N019901 Jan. 28, 1991 RX CAPSULE ORAL 7368469 Aug. 30, 2020 METHOD OF REDUCING RISK OF MYOCARDIAL INFARCTION, STROKE AND DEATH
2.5MG ALTACE KING PHARMS LLC N019901 Jan. 28, 1991 RX CAPSULE ORAL 7368469 Aug. 30, 2020 METHOD OF REDUCING RISK OF MYOCARDIAL INFARCTION, STROKE AND DEATH
5MG ALTACE KING PHARMS LLC N019901 Jan. 28, 1991 RX CAPSULE ORAL 7368469 Aug. 30, 2020 METHOD OF REDUCING RISK OF MYOCARDIAL INFARCTION, STROKE AND DEATH
1.25MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons** ALTACE KING PFIZER N022021 Feb. 27, 2007 DISCN TABLET ORAL 7368469 Aug. 30, 2020 METHOD OF REDUCING RISK OF MYOCARDIAL INFARCTION, STROKE AND DEATH
10MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons** ALTACE KING PFIZER N022021 Feb. 27, 2007 DISCN TABLET ORAL 7368469 Aug. 30, 2020 METHOD OF REDUCING RISK OF MYOCARDIAL INFARCTION, STROKE AND DEATH
2.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons** ALTACE KING PFIZER N022021 Feb. 27, 2007 DISCN TABLET ORAL 7368469 Aug. 30, 2020 METHOD OF REDUCING RISK OF MYOCARDIAL INFARCTION, STROKE AND DEATH
5MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons** ALTACE KING PFIZER N022021 Feb. 27, 2007 DISCN TABLET ORAL 7368469 Aug. 30, 2020 METHOD OF REDUCING RISK OF MYOCARDIAL INFARCTION, STROKE AND DEATH

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR Ki 8.34 WOMBAT-PK CHEMBL
Angiotensin-converting enzyme Enzyme IC50 6.60 CHEMBL

External reference:

IDSource
4019562 VUID
N0000147662 NUI
C0072973 UMLSCUI
D00421 KEGG_DRUG
6N5U4QFC3G UNII
5713 INN_ID
87269-97-4 SECONDARY_CAS_RN
108564000 SNOMEDCT_US
4019562 VANDF
130231 MMSL
003585 NDDF
35296 RXNORM
386872004 SNOMEDCT_US
5411 MMSL
d00728 MMSL
CHEMBL1168 ChEMBL_ID
DB00178 DRUGBANK_ID
X92 PDB_CHEM_ID
CHEBI:8774 CHEBI
CHEMBL1201365 ChEMBL_ID
D017257 MESH_DESCRIPTOR_UI
C052549 MESH_SUPPLEMENTAL_RECORD_UI
5362129 PUBCHEM_CID
6339 IUPHAR_LIGAND_ID
DB14208 DRUGBANK_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0106 CAPSULE 1.25 mg ORAL ANDA 17 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0107 CAPSULE 2.50 mg ORAL ANDA 17 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0108 CAPSULE 5 mg ORAL ANDA 17 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0109 CAPSULE 10 mg ORAL ANDA 17 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 10544-588 CAPSULE 10 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-152 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-153 CAPSULE 2.50 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-154 CAPSULE 5 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-155 CAPSULE 10 mg ORAL ANDA 18 sections
RAMIPRIL HUMAN PRESCRIPTION DRUG LABEL 1 17856-0108 CAPSULE 5 mg ORAL ANDA 16 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-821 CAPSULE 2.50 mg ORAL ANDA 13 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-822 CAPSULE 5 mg ORAL ANDA 13 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-823 CAPSULE 10 mg ORAL ANDA 13 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-271 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-272 CAPSULE 2.50 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-273 CAPSULE 5 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-274 CAPSULE 10 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 33261-903 CAPSULE 5 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 33261-967 CAPSULE 10 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 42291-692 CAPSULE 5 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 45865-441 CAPSULE 10 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 45865-443 CAPSULE 5 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-3873 CAPSULE 2.50 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-4597 CAPSULE 5 mg ORAL ANDA 19 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-4691 CAPSULE 10 mg ORAL ANDA 19 sections
RAMIPRIL HUMAN PRESCRIPTION DRUG LABEL 1 51655-117 TABLET 5 mg ORAL ANDA 15 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 51655-301 CAPSULE 10 mg ORAL ANDA 1 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 54868-5842 CAPSULE 5 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 54868-5843 CAPSULE 10 mg ORAL ANDA 18 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 54868-5856 CAPSULE 2.50 mg ORAL ANDA 18 sections