ramipril ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 2356 87333-19-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • HOE498
  • HOE-498
  • ramipril
A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.
  • Molecular weight: 416.52
  • Formula: C23H32N2O5
  • CLOGP: 1.54
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -4.03
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.69 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 28 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 28, 1991 FDA KING PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 894.23 10.14 2021 145811 226037 50231255
Hyperkalaemia 637.94 10.14 744 147088 47345 50409947
Hyponatraemia 625.48 10.14 1056 146776 95083 50362209
Drug interaction 460.15 10.14 1454 146378 198167 50259125
General physical health deterioration 427.87 10.14 1141 146691 141293 50315999
Angioedema 384.16 10.14 511 147321 37165 50420127
Drug ineffective 367.77 10.14 1203 146629 818130 49639162
Bradycardia 322.45 10.14 632 147200 63794 50393498
Hypotension 310.69 10.14 1436 146396 234033 50223259
Lactic acidosis 282.69 10.14 414 147418 32941 50424351
Syncope 278.15 10.14 794 147038 102208 50355084
Completed suicide 262.00 10.14 37 147795 131852 50325440
Product prescribing error 257.48 10.14 312 147520 20649 50436643
Hypertensive crisis 253.02 10.14 248 147584 12906 50444386
Product dose omission issue 224.62 10.14 129 147703 183709 50273583
Cardiac failure 189.69 10.14 570 147262 75470 50381822
Hypoglycaemia 179.92 10.14 448 147384 53133 50404159
Swollen tongue 177.32 10.14 308 147524 28322 50428970
Confusional state 176.31 10.14 1035 146797 184893 50272399
Pain 157.99 10.14 1018 146814 577885 49879407
Sopor 157.31 10.14 239 147593 19640 50437652
Death 150.30 10.14 470 147362 324909 50132383
Liver injury 149.90 10.14 264 147568 24542 50432750
Fall 140.33 10.14 1545 146287 333387 50123905
Dehydration 137.62 10.14 838 146994 151611 50305681
Eosinophilic bronchitis 133.38 10.14 51 147781 432 50456860
Atrial fibrillation 131.95 10.14 618 147214 101127 50356165
Rhabdomyolysis 128.57 10.14 324 147508 38703 50418589
Sinusitis 117.83 10.14 198 147634 170360 50286932
Off label use 112.21 10.14 869 146963 473557 49983735
Synovitis 111.82 10.14 118 147714 123747 50333545
Myocardial infarction 110.51 10.14 534 147298 88493 50368799
Melaena 110.22 10.14 243 147589 26621 50430671
Product monitoring error 109.27 10.14 79 147753 2685 50454607
Injection site pain 109.22 10.14 98 147734 110926 50346366
Lip swelling 108.64 10.14 230 147602 24506 50432786
Angina pectoris 107.57 10.14 237 147595 25951 50431341
Presyncope 103.97 10.14 223 147609 23975 50433317
Drug hypersensitivity 101.94 10.14 383 147449 250627 50206665
White blood cell count decreased 101.16 10.14 115 147717 116607 50340685
Tongue oedema 100.43 10.14 86 147746 3753 50453539
Labelled drug-drug interaction medication error 97.48 10.14 136 147696 10341 50446951
Orthostatic hypotension 93.20 10.14 241 147591 29240 50428052
International normalised ratio increased 91.54 10.14 306 147526 42846 50414446
Dizziness 89.71 10.14 1465 146367 344904 50112388
Ejection fraction decreased 88.14 10.14 178 147654 18342 50438950
Injection site erythema 88.03 10.14 55 147777 74881 50382411
Electrolyte imbalance 86.50 10.14 169 147663 17000 50440292
Blood pressure increased 83.61 10.14 670 147162 132462 50324830
Circulatory collapse 82.14 10.14 181 147651 19819 50437473
Treatment failure 80.85 10.14 176 147656 137461 50319831
Jaundice 78.40 10.14 211 147621 26218 50431074
Hospitalisation 78.24 10.14 51 147781 67886 50389406
Ischaemic stroke 77.95 10.14 155 147677 15793 50441499
Infection 76.10 10.14 255 147577 172699 50284593
Haematemesis 75.95 10.14 215 147617 27510 50429782
Acute myocardial infarction 75.36 10.14 222 147610 29051 50428241
Rash 74.38 10.14 869 146963 436602 50020690
Abdominal discomfort 72.05 10.14 390 147442 231251 50226041
Asphyxia 71.93 10.14 84 147748 5343 50451949
Device expulsion 71.22 10.14 3 147829 28819 50428473
Alopecia 70.08 10.14 424 147408 244623 50212669
Swelling 68.83 10.14 327 147505 200545 50256747
Glomerular filtration rate decreased 67.80 10.14 122 147710 11530 50445762
Stomatitis 66.89 10.14 121 147711 101223 50356069
Renal failure 64.41 10.14 532 147300 106101 50351191
Renin increased 63.34 10.14 22 147810 137 50457155
Therapeutic product effect decreased 61.61 10.14 198 147634 135852 50321440
Maternal exposure during pregnancy 61.46 10.14 249 147583 159529 50297763
Pallor 60.73 10.14 177 147655 23022 50434270
Orthostatic intolerance 60.62 10.14 37 147795 941 50456351
Arrhythmia 59.97 10.14 223 147609 32909 50424383
Sleep disorder due to general medical condition, insomnia type 59.71 10.14 10 147822 31437 50425855
Exposure during pregnancy 59.17 10.14 170 147662 120845 50336447
Haematoma 59.15 10.14 210 147622 30300 50426992
Injection site pruritus 59.12 10.14 22 147810 40389 50416903
Infusion related reaction 58.08 10.14 276 147556 169281 50288011
Abortion spontaneous 57.43 10.14 25 147807 41747 50415545
Hypersensitivity 56.52 10.14 382 147450 214779 50242513
Polyp 55.97 10.14 75 147757 5487 50451805
Haematochezia 55.92 10.14 248 147584 39634 50417658
Wrong technique in product usage process 55.77 10.14 48 147784 55462 50401830
Anuria 53.42 10.14 108 147724 11136 50446156
Pyrexia 53.26 10.14 786 147046 379417 50077875
Blood creatinine increased 53.18 10.14 393 147439 75767 50381525
Injection site swelling 51.39 10.14 29 147803 41744 50415548
Neutrophilia 50.18 10.14 57 147775 3518 50453774
Systemic lupus erythematosus 49.27 10.14 227 147605 140395 50316897
Platelet count decreased 48.87 10.14 142 147690 100584 50356708
Arteriosclerosis coronary artery 48.38 10.14 83 147749 7553 50449739
Therapeutic product effect incomplete 48.15 10.14 124 147708 91391 50365901
Drug intolerance 48.07 10.14 409 147423 218695 50238597
Pancreatitis acute 47.98 10.14 166 147666 23646 50433646
Migraine 47.80 10.14 92 147740 75188 50382104
Mitral valve incompetence 47.38 10.14 135 147697 17336 50439956
Medication error 47.26 10.14 220 147612 35884 50421408
Cerebral ischaemia 46.69 10.14 71 147761 5837 50451455
Fatigue 45.15 10.14 1653 146179 705948 49751344
Anti-cyclic citrullinated peptide antibody positive 45.05 10.14 86 147746 70501 50386791
Pneumonia 44.48 10.14 808 147024 377593 50079699
Bronchitis 44.13 10.14 156 147676 104003 50353289
Ill-defined disorder 43.99 10.14 57 147775 54597 50402695
Pemphigus 43.88 10.14 191 147641 119975 50337317
Urosepsis 43.41 10.14 121 147711 15344 50441948
Disorientation 43.38 10.14 212 147620 35272 50422020
Gastrointestinal disorder 43.07 10.14 137 147695 94319 50362973
Bradyarrhythmia 42.77 10.14 39 147793 1851 50455441
Pericarditis 42.65 10.14 105 147727 78584 50378708
Patent ductus arteriosus 42.31 10.14 54 147778 3766 50453526
Arthralgia 42.28 10.14 968 146864 437734 50019558
Asthenia 42.16 10.14 1225 146607 317817 50139475
Joint swelling 42.05 10.14 486 147346 244800 50212492
Blood creatine increased 41.87 10.14 61 147771 4826 50452466
Abnormal loss of weight 41.64 10.14 62 147770 5002 50452290
Cerebral haemorrhage 41.60 10.14 173 147659 26879 50430413
Febrile neutropenia 41.56 10.14 146 147686 97521 50359771
Therapy interrupted 41.55 10.14 5 147827 20147 50437145
Muscle injury 41.19 10.14 29 147803 37082 50420210
Renal impairment 40.71 10.14 368 147464 75293 50381999
Bradyphrenia 40.47 10.14 68 147764 6084 50451208
Labile hypertension 40.36 10.14 22 147810 449 50456843
Anaemia 40.11 10.14 993 146839 251463 50205829
Rectal haemorrhage 39.96 10.14 220 147612 38338 50418954
Pemphigoid 39.80 10.14 66 147766 5841 50451451
Hemiparesis 39.73 10.14 139 147693 19909 50437383
Left ventricular dysfunction 39.70 10.14 92 147740 10414 50446878
Disease progression 39.67 10.14 145 147687 95721 50361571
Tachyarrhythmia 39.26 10.14 54 147778 4051 50453241
Weight increased 39.03 10.14 389 147443 201502 50255790
Hypokalaemia 39.02 10.14 411 147421 87581 50369711
Vomiting 38.99 10.14 1681 146151 459077 49998215
No adverse event 38.93 10.14 25 147807 33553 50423739
Limb reduction defect 38.59 10.14 20 147812 367 50456925
Diabetic metabolic decompensation 38.40 10.14 33 147799 1447 50455845
Lip oedema 38.34 10.14 47 147785 3146 50454146
Electrocardiogram QT prolonged 38.09 10.14 271 147561 51615 50405677
Headache 37.94 10.14 1159 146673 505376 49951916
Irritable bowel syndrome 37.09 10.14 58 147774 51383 50405909
Blood creatine phosphokinase increased 36.99 10.14 164 147668 26203 50431089
Skin weeping 36.87 10.14 20 147812 404 50456888
Change of bowel habit 36.87 10.14 35 147797 1749 50455543
Obstructive airways disorder 36.81 10.14 115 147717 15537 50441755
Troponin I increased 36.45 10.14 36 147796 1890 50455402
Gingival hypertrophy 36.15 10.14 31 147801 1355 50455937
Inappropriate antidiuretic hormone secretion 36.07 10.14 102 147730 13041 50444251
Folliculitis 35.78 10.14 37 147795 39188 50418104
Unevaluable event 35.09 10.14 50 147782 46016 50411276
Congestive cardiomyopathy 34.98 10.14 60 147772 5458 50451834
Atrioventricular block first degree 34.90 10.14 64 147768 6137 50451155
Cholestasis 34.89 10.14 157 147675 25244 50432048
Bicuspid aortic valve 34.86 10.14 13 147819 102 50457190
Dysmorphism 34.66 10.14 37 147795 2130 50455162
Hyperglycaemia 34.62 10.14 203 147629 36202 50421090
Injection site reaction 34.58 10.14 58 147774 49974 50407318
Therapeutic drug monitoring analysis not performed 34.56 10.14 23 147809 682 50456610
Feeling abnormal 34.33 10.14 220 147612 125272 50332020
Surgery 34.33 10.14 23 147809 30182 50427110
Arterial occlusive disease 34.13 10.14 55 147777 4753 50452539
Coronary artery disease 33.80 10.14 174 147658 29552 50427740
Bundle branch block left 33.44 10.14 63 147769 6167 50451125
Chest pain 33.42 10.14 713 147119 176169 50281123
Neuropathy peripheral 33.40 10.14 157 147675 96600 50360692
Multiple sclerosis relapse 33.36 10.14 46 147786 42918 50414374
Dyspnoea 33.29 10.14 1935 145897 545673 49911619
Pancreatitis necrotising 32.75 10.14 29 147803 1324 50455968
Upper respiratory tract infection 32.61 10.14 92 147740 65806 50391486
Hand deformity 32.61 10.14 166 147666 100033 50357259
Device issue 32.53 10.14 9 147823 19963 50437329
Atrioventricular block complete 32.48 10.14 68 147764 7187 50450105
Gangrene 32.39 10.14 53 147779 4639 50452653
Arthropathy 32.30 10.14 300 147532 157606 50299686
Liver function test abnormal 32.20 10.14 231 147601 44108 50413184
Nasopharyngitis 31.98 10.14 385 147447 192542 50264750
COVID-19 31.42 10.14 55 147777 46607 50410685
Systemic infection 31.37 10.14 36 147796 2247 50455045
Gamma-glutamyltransferase increased 31.35 10.14 170 147662 29453 50427839
Cerebrovascular accident 31.27 10.14 418 147414 94262 50363030
Impaired healing 31.27 10.14 102 147730 69684 50387608
Duodenal ulcer 30.91 10.14 64 147768 6711 50450581
Glossodynia 30.90 10.14 204 147628 115365 50341927
Intestinal haemorrhage 30.66 10.14 42 147790 3138 50454154
Hypercreatininaemia 30.46 10.14 17 147815 364 50456928
Dysarthria 30.20 10.14 200 147632 37203 50420089
Bundle branch block right 30.10 10.14 51 147781 4594 50452698
Mucosal dryness 29.71 10.14 36 147796 2381 50454911
Atrioventricular block 29.33 10.14 61 147771 6417 50450875
Gastroenteritis clostridial 29.17 10.14 19 147813 543 50456749
Angina unstable 29.03 10.14 62 147770 6644 50450648
Injection site rash 28.88 10.14 6 147826 16171 50441121
Parkinsonism 28.65 10.14 73 147759 8774 50448518
Accidental exposure to product 28.37 10.14 16 147816 23041 50434251
Influenza 28.20 10.14 150 147682 89388 50367904
Tachycardia 27.98 10.14 428 147404 99335 50357957
Injection site bruising 27.91 10.14 40 147792 36728 50420564
Respiratory tract inflammation 27.40 10.14 18 147814 522 50456770
Drug ineffective for unapproved indication 27.31 10.14 14 147818 21267 50436025
Reduced facial expression 26.89 10.14 28 147804 1566 50455726
Agitation 26.87 10.14 256 147576 53128 50404164
Diabetes mellitus inadequate control 26.79 10.14 92 147740 13053 50444239
Palpitations 26.72 10.14 406 147426 94100 50363192
Eosinophil count increased 26.69 10.14 71 147761 8759 50448533
Respiratory arrest 26.60 10.14 29 147803 29980 50427312
Fungal infection 26.51 10.14 29 147803 29936 50427356
Hypothermia 26.17 10.14 86 147746 11930 50445362
Eosinophilia 26.15 10.14 116 147716 18536 50438756
Oedema peripheral 26.15 10.14 625 147207 157336 50299956
Hypovolaemic shock 26.05 10.14 51 147781 5137 50452155
Acute coronary syndrome 25.97 10.14 73 147759 9301 50447991
Product use in unapproved indication 25.91 10.14 215 147617 115604 50341688
Hypoglycaemic coma 25.87 10.14 33 147799 2300 50454992
Swelling face 25.87 10.14 251 147581 52344 50404948
Pregnancy 25.75 10.14 29 147803 29548 50427744
Device stimulation issue 25.52 10.14 9 147823 59 50457233
Adverse drug reaction 25.23 10.14 80 147752 55142 50402150
Limb hypoplasia congenital 25.08 10.14 12 147820 184 50457108
Electrocardiogram abnormal 24.89 10.14 63 147769 7542 50449750
Drug withdrawal syndrome 24.81 10.14 22 147810 25059 50432233
Heat stroke 24.56 10.14 18 147814 625 50456667
Atrial septal defect 24.48 10.14 56 147776 6285 50451007
Peripheral arterial occlusive disease 24.48 10.14 40 147792 3497 50453795
Delirium 24.36 10.14 193 147639 37999 50419293
Restlessness 24.34 10.14 141 147691 25032 50432260
Herpes zoster 24.34 10.14 115 147717 70671 50386621
Gastrointestinal haemorrhage 24.33 10.14 324 147508 72997 50384295
Loss of consciousness 24.21 10.14 434 147398 103919 50353373
Talipes 24.14 10.14 25 147807 1389 50455903
Renal artery stenosis 24.05 10.14 27 147805 1645 50455647
Hepatitis acute 24.05 10.14 64 147768 7897 50449395
Loss of personal independence in daily activities 23.97 10.14 114 147718 69936 50387356
Dermatitis exfoliative 23.96 10.14 49 147783 5093 50452199
Fracture 23.84 10.14 105 147727 16728 50440564
Electrocardiogram repolarisation abnormality 23.77 10.14 23 147809 1177 50456115
Drug resistance 23.62 10.14 13 147819 18976 50438316
Abdominal pain upper 23.60 10.14 621 147211 158688 50298604
Acute pulmonary oedema 23.57 10.14 60 147772 7207 50450085
Left ventricular hypertrophy 23.57 10.14 47 147785 4798 50452494
Flushing 23.56 10.14 108 147724 66907 50390385
Sedation 23.54 10.14 33 147799 30577 50426715
Inappropriate schedule of product administration 23.37 10.14 119 147713 71712 50385580
Hepatorenal failure 23.30 10.14 17 147815 586 50456706
Urine output decreased 23.07 10.14 75 147757 10346 50446946
Hypertensive angiopathy 23.06 10.14 9 147823 81 50457211
Erysipelas 22.95 10.14 56 147776 6552 50450740
Thrombocytosis 22.56 10.14 47 147785 4949 50452343
Device malfunction 22.51 10.14 8 147824 15113 50442179
Brain stem stroke 22.50 10.14 12 147820 234 50457058
Mental status changes 22.44 10.14 45 147787 36227 50421065
Colitis microscopic 22.38 10.14 55 147777 6465 50450827
Chest wall haematoma 22.35 10.14 11 147821 180 50457112
Faecaloma 22.35 10.14 58 147774 7050 50450242
Product use issue 22.27 10.14 305 147527 149170 50308122
Myelosuppression 22.19 10.14 6 147826 13511 50443781
Basilar artery thrombosis 22.17 10.14 10 147822 133 50457159
Congenital oral malformation 22.14 10.14 11 147821 184 50457108
Therapy cessation 22.11 10.14 26 147806 25985 50431307
Nephritic syndrome 22.08 10.14 11 147821 185 50457107
Congenital choroid plexus cyst 21.97 10.14 13 147819 312 50456980
Cerebral artery occlusion 21.96 10.14 19 147813 841 50456451
Cardiovascular insufficiency 21.93 10.14 23 147809 1297 50455995
Cardioactive drug level increased 21.90 10.14 28 147804 1956 50455336
Joint injury 21.69 10.14 19 147813 21770 50435522
Cardiac failure chronic 21.62 10.14 38 147794 3525 50453767
Vertigo 21.53 10.14 239 147593 51593 50405699
Myopathy 21.35 10.14 67 147765 9072 50448220
Congenital aortic valve stenosis 21.21 10.14 8 147824 65 50457227
Retrognathia 21.19 10.14 14 147818 410 50456882
Therapeutic response unexpected 21.13 10.14 10 147822 15905 50441387
Product quality issue 21.11 10.14 36 147796 30822 50426470
Blood glucose fluctuation 21.11 10.14 41 147791 4105 50453187
Ear infection 20.98 10.14 27 147805 25943 50431349
Discomfort 20.84 10.14 209 147623 108171 50349121
Fluid retention 20.69 10.14 77 147755 50572 50406720
Hypomagnesaemia 20.66 10.14 127 147705 23029 50434263
Frontotemporal dementia 20.62 10.14 12 147820 279 50457013
Oral dysaesthesia 20.50 10.14 8 147824 72 50457220
Chills 20.50 10.14 182 147650 96505 50360787
Abnormal clotting factor 20.42 10.14 9 147823 113 50457179
Viral diarrhoea 20.21 10.14 9 147823 116 50457176
Psoriatic arthropathy 20.05 10.14 218 147614 46814 50410478
Irregular sleep wake rhythm disorder 20.03 10.14 10 147822 169 50457123
Urinary retention 19.92 10.14 138 147694 26052 50431240
Dilatation ventricular 19.89 10.14 29 147803 2296 50454996
Peripheral swelling 19.87 10.14 454 147378 205482 50251810
Psychogenic tremor 19.85 10.14 6 147826 22 50457270
Visceral congestion 19.84 10.14 12 147820 300 50456992
Congenital renal cyst 19.84 10.14 5 147827 7 50457285
Abdominal pain 19.71 10.14 861 146971 235367 50221925
Arterial stenosis 19.66 10.14 15 147817 554 50456738
Bone erosion 19.54 10.14 5 147827 11682 50445610
Coma scale abnormal 19.39 10.14 43 147789 4728 50452564
Psoriasis 19.36 10.14 120 147712 68880 50388412
Macrophage activation 19.36 10.14 4 147828 0 50457292
Hallucination 19.32 10.14 215 147617 46442 50410850
Listless 19.28 10.14 29 147803 2361 50454931
Tooth dislocation 19.06 10.14 6 147826 26 50457266
Chronic cutaneous lupus erythematosus 18.99 10.14 9 147823 135 50457157
Laboratory test abnormal 18.88 10.14 24 147808 23184 50434108
Rhinorrhoea 18.81 10.14 82 147750 51501 50405791
Nephrosclerosis 18.79 10.14 18 147814 910 50456382
Lethargy 18.77 10.14 224 147608 49208 50408084
Stoma site haemorrhage 18.58 10.14 18 147814 923 50456369
Blood lactic acid 18.55 10.14 8 147824 95 50457197
Transient ischaemic attack 18.52 10.14 159 147673 32051 50425241
C-reactive protein abnormal 18.52 10.14 33 147799 27776 50429516
Excessive eye blinking 18.49 10.14 18 147814 928 50456364
Kidney fibrosis 18.45 10.14 23 147809 1566 50455726
Ear pain 18.44 10.14 34 147798 28249 50429043
Plasma cell myeloma 18.41 10.14 40 147792 31282 50426010
Jaundice hepatocellular 18.37 10.14 6 147826 30 50457262
Transplant rejection 18.36 10.14 3 147829 9606 50447686
Blood pressure systolic increased 18.34 10.14 171 147661 35278 50422014
Complication associated with device 18.27 10.14 10 147822 14645 50442647
Polyneuropathy 18.20 10.14 77 147755 12054 50445238
Neutrophil count decreased 18.13 10.14 71 147761 45955 50411337
Hyponatraemic syndrome 18.05 10.14 14 147818 530 50456762
Bronchomalacia 18.01 10.14 10 147822 212 50457080
Thirst 17.88 10.14 70 147762 10580 50446712
Device dislocation 17.82 10.14 22 147810 21524 50435768
Bacteraemia 17.78 10.14 10 147822 14423 50442869
Contraindicated product administered 17.78 10.14 317 147515 148641 50308651
Sinus bradycardia 17.74 10.14 81 147751 13102 50444190
Seizure 17.74 10.14 240 147592 117634 50339658
Shock haemorrhagic 17.53 10.14 59 147773 8285 50449007
Brain stem infarction 17.52 10.14 16 147816 761 50456531
Hepatic enzyme increased 17.48 10.14 289 147543 137091 50320201
Tension 17.47 10.14 30 147802 2732 50454560
Prescription drug used without a prescription 17.22 10.14 23 147809 1677 50455615
Intentional product misuse 17.22 10.14 74 147758 46660 50410632
Hypertensive emergency 17.16 10.14 22 147810 1541 50455751
Malaise 17.06 10.14 1168 146664 334364 50122928
Oropharyngeal swelling 17.02 10.14 16 147816 790 50456502
Back pain 17.00 10.14 501 147331 219529 50237763
Congestive hepatopathy 16.98 10.14 28 147804 2466 50454826
Cardiomyopathy 16.87 10.14 90 147742 15496 50441796
Mitral valve atresia 16.84 10.14 5 147827 17 50457275
Electrocardiogram QT shortened 16.82 10.14 8 147824 121 50457171
Thrombosis 16.77 10.14 95 147737 55738 50401554
Abdominal pain lower 16.76 10.14 115 147717 21641 50435651
Colitis erosive 16.70 10.14 7 147825 77 50457215
Superinfection 16.66 10.14 25 147807 2031 50455261
Tongue biting 16.66 10.14 20 147812 1310 50455982
Pain in jaw 16.64 10.14 57 147775 38371 50418921
Blood potassium increased 16.61 10.14 93 147739 16305 50440987
Mitral valve disease 16.57 10.14 25 147807 2041 50455251
Fracture blisters 16.54 10.14 7 147825 79 50457213
Sciatica 16.46 10.14 113 147719 21269 50436023
Cleft palate 16.40 10.14 17 147815 946 50456346
Multiple drug therapy 16.34 10.14 24 147808 1913 50455379
Adverse event 16.30 10.14 69 147763 43694 50413598
Pharyngitis streptococcal 16.29 10.14 3 147829 8805 50448487
Prescribed overdose 16.27 10.14 85 147747 14515 50442777
Sinus arrhythmia 16.19 10.14 20 147812 1349 50455943
Sedation complication 16.18 10.14 3 147829 8763 50448529
Heavy menstrual bleeding 16.14 10.14 13 147819 15524 50441768
Vasodilatation 16.08 10.14 26 147806 2253 50455039
Hemianopia 15.80 10.14 16 147816 866 50456426
Injection site urticaria 15.73 10.14 8 147824 12209 50445083
Ketoacidosis 15.71 10.14 35 147797 3860 50453432
Idiopathic angioedema 15.71 10.14 4 147828 6 50457286
Cardiac valve sclerosis 15.65 10.14 5 147827 23 50457269
Coronary artery stenosis 15.60 10.14 37 147795 4252 50453040
Pulmonary mass 15.58 10.14 19 147813 18686 50438606
Illness 15.56 10.14 30 147802 24510 50432782
Apathy 15.53 10.14 53 147779 7495 50449797
Arteriosclerosis 15.52 10.14 60 147772 9017 50448275
Amenorrhoea 15.45 10.14 3 147829 8481 50448811
Stupor 15.36 10.14 33 147799 3550 50453742
Blood sodium decreased 15.25 10.14 110 147722 21037 50436255
Faecal vomiting 15.24 10.14 13 147819 564 50456728
Gastritis erosive 15.23 10.14 41 147791 5093 50452199
Cytomegalovirus infection 15.22 10.14 18 147814 17944 50439348
Acute abdomen 15.22 10.14 20 147812 1436 50455856
Traumatic haemorrhage 15.21 10.14 12 147820 466 50456826
Disturbance in social behaviour 15.20 10.14 29 147803 2865 50454427
Hypersensitivity vasculitis 15.00 10.14 35 147797 3980 50453312
Retinal artery occlusion 14.88 10.14 20 147812 1467 50455825
Subdural haematoma 14.86 10.14 76 147756 12871 50444421
Hypoxia 14.81 10.14 88 147744 51035 50406257
Osmotic demyelination syndrome 14.80 10.14 13 147819 587 50456705
Gastrointestinal angiodysplasia 14.66 10.14 11 147821 396 50456896
Rabbit syndrome 14.64 10.14 10 147822 310 50456982
Neck pain 14.61 10.14 102 147730 56965 50400327
Splenic vein thrombosis 14.61 10.14 10 147822 311 50456981
Aortic valve incompetence 14.54 10.14 42 147790 5434 50451858
Malignant neoplasm progression 14.54 10.14 128 147704 67996 50389296
Euglycaemic diabetic ketoacidosis 14.50 10.14 28 147804 2791 50454501
Mouth swelling 14.48 10.14 34 147798 3882 50453410
Intestinal obstruction 14.45 10.14 35 147797 26348 50430944
Full blood count decreased 14.45 10.14 27 147805 22319 50434973
Dementia 14.43 10.14 88 147744 15909 50441383
Hypertelorism 14.42 10.14 11 147821 406 50456886
Sensory level abnormal 14.37 10.14 7 147825 112 50457180
Seasonal allergy 14.36 10.14 13 147819 14663 50442629
Rheumatoid factor positive 14.35 10.14 86 147746 49773 50407519
Oral herpes 14.34 10.14 24 147808 20701 50436591
Insulin-requiring type 2 diabetes mellitus 14.32 10.14 6 147826 66 50457226
Accidental overdose 14.31 10.14 102 147730 19431 50437861
Gastrointestinal ischaemia 14.30 10.14 8 147824 172 50457120
Paranoia 14.24 10.14 64 147768 10284 50447008
Acne 14.21 10.14 22 147810 19573 50437719
Hallucination, visual 14.20 10.14 90 147742 16492 50440800
Helicobacter infection 14.17 10.14 86 147746 49616 50407676
Eyelid bleeding 14.15 10.14 5 147827 33 50457259
Agranulocytosis 14.07 10.14 109 147723 21312 50435980
Anxiety 14.06 10.14 403 147429 177203 50280089
Hyperparathyroidism primary 14.06 10.14 10 147822 331 50456961
Insomnia 14.04 10.14 396 147436 174469 50282823
Duodenal ulcer perforation 14.03 10.14 77 147755 45534 50411758
Haematuria 13.98 10.14 125 147707 25488 50431804
Skin irritation 13.97 10.14 52 147780 7675 50449617
Disturbance in attention 13.97 10.14 146 147686 31040 50426252
Therapeutic response decreased 13.84 10.14 81 147751 47150 50410142
Respiratory depression 13.84 10.14 9 147823 12001 50445291
Hepatic function abnormal 13.80 10.14 49 147783 32632 50424660
Malignant neoplasm of unknown primary site 13.79 10.14 9 147823 258 50457034
Epistaxis 13.79 10.14 263 147569 63691 50393601
Nasal congestion 13.77 10.14 90 147742 51030 50406262
Gastric ulcer 13.77 10.14 108 147724 21197 50436095
Laryngeal oedema 13.65 10.14 39 147793 5014 50452278
Wound 13.63 10.14 222 147610 105572 50351720
Injection site haemorrhage 13.62 10.14 26 147806 21320 50435972
Diabetes mellitus 13.60 10.14 210 147622 48823 50408469
Hypoaesthesia 13.58 10.14 276 147556 126981 50330311
Exercise tolerance decreased 13.54 10.14 38 147794 4836 50452456
Skin candida 13.53 10.14 18 147814 1308 50455984
Peripartum cardiomyopathy 13.48 10.14 7 147825 129 50457163
Erythrodermic psoriasis 13.47 10.14 15 147817 906 50456386
Aortic valve stenosis 13.45 10.14 28 147804 2947 50454345
Multiple allergies 13.44 10.14 4 147828 8459 50448833
Pneumonia herpes viral 13.43 10.14 5 147827 39 50457253
Vulval cancer 13.36 10.14 13 147819 670 50456622
Neoplasm malignant 13.36 10.14 31 147801 23684 50433608
Neurotoxicity 13.33 10.14 14 147818 14726 50442566
Adrenocortical carcinoma 13.32 10.14 5 147827 40 50457252
Eye infarction 13.32 10.14 5 147827 40 50457252
Ureteric stenosis 13.20 10.14 12 147820 567 50456725
Pancreatic neuroendocrine tumour 13.17 10.14 9 147823 279 50457013
Red blood cell sedimentation rate increased 13.17 10.14 43 147789 29373 50427919
Acidosis 13.14 10.14 62 147770 10165 50447127
Productive cough 13.09 10.14 95 147737 52599 50404693
Aortic arteriosclerosis 13.08 10.14 40 147792 5342 50451950
Paradoxical psoriasis 13.06 10.14 7 147825 138 50457154
Toxic neuropathy 13.05 10.14 10 147822 372 50456920
Multiple sclerosis 13.04 10.14 25 147807 20468 50436824
Gingival swelling 13.01 10.14 32 147800 3763 50453529
Psychomotor retardation 12.99 10.14 30 147802 3388 50453904
Suffocation feeling 12.95 10.14 17 147815 1219 50456073
Cardiogenic shock 12.95 10.14 84 147748 15515 50441777
Diabetic ketoacidosis 12.91 10.14 93 147739 17779 50439513
Decreased appetite 12.91 10.14 714 147118 200209 50257083
Thyroxine decreased 12.90 10.14 11 147821 477 50456815
Intracardiac thrombus 12.84 10.14 23 147809 2166 50455126
Pulmonary arterial hypertension 12.74 10.14 25 147807 20294 50436998
Apnoea 12.70 10.14 47 147785 6919 50450373
Continuous haemodiafiltration 12.68 10.14 15 147817 967 50456325
Periorbital haematoma 12.68 10.14 13 147819 714 50456578
Underdose 12.68 10.14 25 147807 20253 50437039
Orthopnoea 12.65 10.14 41 147791 5648 50451644
Metabolic acidosis 12.64 10.14 171 147661 38654 50418638
Nodal arrhythmia 12.62 10.14 16 147816 1108 50456184
Duodenogastric reflux 12.53 10.14 5 147827 48 50457244
Myocardial ischaemia 12.53 10.14 67 147765 11546 50445746
Bacterial infection 12.51 10.14 86 147746 16195 50441097
Facet joint syndrome 12.45 10.14 24 147808 2389 50454903
Jaundice cholestatic 12.43 10.14 38 147794 5073 50452219
Acquired diaphragmatic eventration 12.40 10.14 10 147822 401 50456891
Genital infection female 12.37 10.14 6 147826 95 50457197
Anaphylactoid shock 12.37 10.14 9 147823 309 50456983
Pharyngitis 12.36 10.14 20 147812 17483 50439809
Dystonia 12.36 10.14 10 147822 11916 50445376
Vaginal haemorrhage 12.35 10.14 34 147798 24517 50432775
Oral discharge 12.29 10.14 7 147825 156 50457136
Oral candidiasis 12.26 10.14 19 147813 16896 50440396
Myoglobinaemia 12.25 10.14 4 147828 20 50457272
Anal paraesthesia 12.25 10.14 4 147828 20 50457272
Genital paraesthesia 12.25 10.14 4 147828 20 50457272
Ultrasound liver abnormal 12.25 10.14 4 147828 20 50457272
Influenza like illness 12.24 10.14 108 147724 57351 50399941
Red blood cell count decreased 12.20 10.14 54 147778 33781 50423511
International normalised ratio decreased 12.18 10.14 33 147799 4115 50453177
Muscle discomfort 12.15 10.14 6 147826 99 50457193
Sleep-related eating disorder 12.08 10.14 13 147819 755 50456537
Hysterectomy 12.05 10.14 4 147828 7886 50449406
Toxicity to various agents 12.00 10.14 503 147329 211996 50245296
Sweat gland tumour 11.99 10.14 6 147826 102 50457190
Transfusion 11.97 10.14 12 147820 12893 50444399
Norovirus infection 11.94 10.14 8 147824 240 50457052
Gastric cyst 11.94 10.14 6 147826 103 50457189
Pseudomyopia 11.93 10.14 5 147827 55 50457237
Neutropenia 11.90 10.14 335 147497 147630 50309662
Miosis 11.86 10.14 43 147789 6267 50451025
Drop attacks 11.84 10.14 12 147820 650 50456642
Brain compression 11.83 10.14 9 147823 331 50456961
Hepatic steatosis 11.81 10.14 116 147716 24268 50433024
Irritability 11.75 10.14 43 147789 28383 50428909
Prothrombin time shortened 11.74 10.14 19 147813 1648 50455644
Foot deformity 11.74 10.14 24 147808 19186 50438106
Euphoric mood 11.65 10.14 32 147800 4023 50453269
Diarrhoea infectious 11.65 10.14 14 147818 918 50456374
Injection site warmth 11.64 10.14 14 147818 13852 50443440
Left ventricular enlargement 11.62 10.14 5 147827 59 50457233
Vascular pseudoaneurysm ruptured 11.62 10.14 5 147827 59 50457233
Cardio-respiratory arrest 11.61 10.14 101 147731 53791 50403501
Coma acidotic 11.53 10.14 6 147826 111 50457181
Clostridium difficile infection 11.52 10.14 37 147795 25402 50431890
Cholecystitis chronic 11.48 10.14 7 147825 9662 50447630
Tubulointerstitial nephritis 11.48 10.14 80 147752 15131 50442161
Cystitis noninfective 11.46 10.14 13 147819 801 50456491
Troponin T increased 11.43 10.14 14 147818 936 50456356
Memory impairment 11.43 10.14 163 147669 79197 50378095
Tricuspid valve incompetence 11.37 10.14 70 147762 12700 50444592
Abnormal behaviour 11.28 10.14 97 147735 19561 50437731
Pneumonia viral 11.28 10.14 3 147829 6831 50450461
Bacteriuria 11.27 10.14 12 147820 689 50456603
Oral contusion 11.26 10.14 5 147827 64 50457228
Fibrinous bronchitis 11.24 10.14 3 147829 6 50457286
Oedema due to hepatic disease 11.24 10.14 3 147829 6 50457286
Device breakage 11.22 10.14 7 147825 9540 50447752
Respiratory failure 11.20 10.14 193 147639 90988 50366304
Temperature intolerance 11.20 10.14 4 147828 7535 50449757
Invasive breast carcinoma 11.19 10.14 11 147821 574 50456718
Diffuse vasculitis 11.12 10.14 4 147828 28 50457264
Cardiovascular disorder 11.06 10.14 60 147772 10394 50446898
Hepatic fibrosis 10.98 10.14 27 147805 3175 50454117
Cerebral haematoma 10.93 10.14 27 147805 3184 50454108
Urethral prolapse 10.93 10.14 3 147829 7 50457285
Mydriasis 10.90 10.14 9 147823 10618 50446674
Infusion site pain 10.86 10.14 12 147820 12334 50444958
Brain stem ischaemia 10.86 10.14 5 147827 70 50457222
Head discomfort 10.83 10.14 62 147770 10957 50446335
Foetal growth restriction 10.77 10.14 3 147829 6624 50450668
Skin infection 10.76 10.14 12 147820 12279 50445013
Monoparesis 10.74 10.14 17 147815 1447 50455845
Neuroleptic malignant syndrome 10.73 10.14 10 147822 11120 50446172
Asthma 10.69 10.14 190 147642 89147 50368145
Lip blister 10.68 10.14 20 147812 1949 50455343
Glutamate dehydrogenase increased 10.66 10.14 4 147828 32 50457260
Gravitational oedema 10.65 10.14 15 147817 1150 50456142
Blood osmolarity abnormal 10.64 10.14 3 147829 8 50457284
Product storage error 10.63 10.14 12 147820 12212 50445080
Contusion 10.62 10.14 248 147584 111935 50345357
Nodule 10.60 10.14 21 147811 16982 50440310
Chorioretinal scar 10.55 10.14 4 147828 33 50457259
Refeeding syndrome 10.55 10.14 4 147828 33 50457259
Prothrombin time abnormal 10.54 10.14 9 147823 391 50456901
Soft tissue necrosis 10.48 10.14 9 147823 394 50456898
Cerebral ventricle collapse 10.45 10.14 4 147828 34 50457258
Drug reaction with eosinophilia and systemic symptoms 10.44 10.14 128 147704 28296 50428996
Carotid artery stenosis 10.43 10.14 34 147798 4697 50452595
Metabolic syndrome 10.38 10.14 16 147816 1331 50455961
Peripheral paralysis 10.37 10.14 5 147827 78 50457214
Hyperthyroidism 10.37 10.14 66 147766 12109 50445183
Congenital mitral valve incompetence 10.35 10.14 4 147828 35 50457257
Genital lesion 10.33 10.14 7 147825 214 50457078
Spasmodic dysphonia 10.32 10.14 5 147827 79 50457213
Ankylosing spondylitis 10.31 10.14 4 147828 7161 50450131
Subdural haemorrhage 10.31 10.14 24 147808 2725 50454567
Blood cholesterol decreased 10.27 10.14 12 147820 764 50456528
Arthritis 10.20 10.14 185 147647 86536 50370756
HELLP syndrome 10.19 10.14 13 147819 906 50456386
Vascular purpura 10.18 10.14 15 147817 1199 50456093
Intraventricular haemorrhage 10.15 10.14 19 147813 1851 50455441
Blood copper increased 10.15 10.14 3 147829 10 50457282
Food interaction 10.14 10.14 11 147821 645 50456647
Micturition disorder 10.14 10.14 19 147813 1852 50455440

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 552.13 10.53 2715 146296 262552 29162964
Death 510.85 10.53 585 148426 341499 29084017
General physical health deterioration 394.81 10.53 1277 147734 101580 29323936
Angioedema 344.92 10.53 595 148416 31320 29394196
Hyperkalaemia 336.95 10.53 867 148144 60525 29364991
Drug ineffective 300.62 10.53 891 148120 362279 29063237
Hypertensive crisis 278.84 10.53 265 148746 7583 29417933
Syncope 260.13 10.53 951 148060 80420 29345096
Off label use 224.00 10.53 773 148238 300027 29125489
Completed suicide 217.75 10.53 91 148920 90155 29335361
Bradycardia 216.43 10.53 775 148236 64854 29360662
Hypotension 187.46 10.53 1642 147369 192712 29232804
Product dose omission issue 180.80 10.53 133 148878 96250 29329266
Toxicity to various agents 178.04 10.53 381 148630 173280 29252236
Cardiac failure 177.04 10.53 830 148181 78457 29347059
Febrile neutropenia 174.29 10.53 185 148826 112055 29313461
Product prescribing error 173.38 10.53 319 148692 17657 29407859
Presyncope 162.13 10.53 291 148720 15798 29409718
Angina pectoris 150.22 10.53 391 148620 27459 29398057
Drug interaction 146.16 10.53 1578 147433 195807 29229709
Dyspnoea 139.07 10.53 2363 146648 324369 29101147
Swollen tongue 138.12 10.53 233 148778 12033 29413483
Myocardial infarction 133.41 10.53 982 148029 109314 29316202
Neutropenia 133.19 10.53 291 148720 131420 29294096
Platelet count decreased 132.86 10.53 201 148810 104471 29321045
Pneumonia 129.59 10.53 1014 147997 319158 29106358
Lip swelling 128.30 10.53 227 148784 12183 29413333
Atrial fibrillation 118.41 10.53 924 148087 104722 29320794
White blood cell count decreased 115.81 10.53 150 148861 83212 29342304
Coronary artery disease 115.48 10.53 485 148526 43705 29381811
Dizziness 112.25 10.53 1453 147558 188231 29237285
Disease progression 109.13 10.53 152 148859 81764 29343752
Orthostatic hypotension 106.31 10.53 302 148709 22327 29403189
Neuropathy peripheral 105.85 10.53 121 148890 70906 29354610
Tongue oedema 105.43 10.53 94 148917 2472 29423044
Drug abuse 101.71 10.53 153 148858 79730 29345786
Acute myocardial infarction 98.61 10.53 494 148517 47944 29377572
Lactic acidosis 96.89 10.53 354 148657 29893 29395623
Haematochezia 92.82 10.53 401 148610 36582 29388934
Pyrexia 91.36 10.53 968 148043 286654 29138862
Hypoglycaemia 90.73 10.53 482 148529 47864 29377652
Acute coronary syndrome 88.01 10.53 193 148818 12132 29413384
Sopor 83.56 10.53 176 148835 10758 29414758
Circulatory collapse 82.69 10.53 244 148767 18429 29407087
Product use in unapproved indication 82.04 10.53 199 148812 86676 29338840
Hyponatraemia 81.00 10.53 601 148410 67032 29358484
Ejection fraction decreased 78.74 10.53 217 148794 15761 29409755
Hospitalisation 75.64 10.53 72 148939 45916 29379600
Cardiac failure chronic 74.33 10.53 124 148887 6343 29419173
Melaena 72.90 10.53 331 148680 30845 29394671
Oedema peripheral 71.87 10.53 818 148193 102739 29322777
Product monitoring error 71.40 10.53 77 148934 2568 29422948
Treatment failure 70.46 10.53 50 148961 36889 29388627
Drug hypersensitivity 70.00 10.53 150 148861 68256 29357260
Malignant neoplasm progression 69.87 10.53 169 148842 73690 29351826
Pallor 69.81 10.53 249 148762 20775 29404741
Respiratory failure 69.66 10.53 253 148758 96878 29328638
Palatal oedema 68.83 10.53 44 148967 687 29424829
Hepatic function abnormal 68.72 10.53 58 148953 39201 29386315
Vertigo 67.60 10.53 253 148758 21608 29403908
Cytomegalovirus infection 67.21 10.53 17 148994 23198 29402318
Plasma cell myeloma 65.99 10.53 54 148957 37061 29388455
Fall 65.99 10.53 1256 147755 175922 29249594
Electrolyte imbalance 65.67 10.53 163 148848 11111 29414405
Drug dependence 65.50 10.53 13 148998 20968 29404548
Electrocardiogram abnormal 64.46 10.53 125 148886 7197 29418319
Loss of consciousness 63.65 10.53 611 148400 73445 29352071
Arrhythmia 62.05 10.53 317 148694 30996 29394520
Myalgia 61.31 10.53 606 148405 73413 29352103
Hepatojugular reflux 61.09 10.53 35 148976 443 29425073
Ventricular arrhythmia 57.97 10.53 92 148919 4512 29421004
Neutrophil count decreased 57.82 10.53 81 148930 43486 29382030
Mitral valve incompetence 56.30 10.53 171 148840 13122 29412394
Rash 55.30 10.53 651 148360 189168 29236348
Hypoxia 54.43 10.53 97 148914 47282 29378234
Exercise tolerance decreased 53.90 10.53 85 148926 4146 29421370
Glomerular filtration rate decreased 53.53 10.53 151 148860 11115 29414401
Left ventricular dysfunction 53.22 10.53 130 148881 8772 29416744
Labelled drug-drug interaction medication error 52.04 10.53 157 148854 12002 29413514
Full blood count decreased 51.87 10.53 9 149002 15983 29409533
Sepsis 51.52 10.53 465 148546 142217 29283299
Rhabdomyolysis 49.93 10.53 497 148514 60311 29365205
Urogenital haemorrhage 49.91 10.53 31 148980 459 29425057
Haematuria 49.87 10.53 387 148624 43752 29381764
Sinusitis 49.55 10.53 60 148951 34290 29391226
Drug intolerance 49.55 10.53 106 148905 48273 29377243
Computerised tomogram coronary artery abnormal 49.09 10.53 23 148988 185 29425331
Intentional product use issue 47.04 10.53 89 148922 42409 29383107
Cerebral haemorrhage 45.11 10.53 292 148719 31134 29394382
Tricuspid valve incompetence 44.37 10.53 117 148894 8277 29417239
Dyspnoea at rest 44.35 10.53 67 148944 3147 29422369
Mental status changes 44.32 10.53 67 148944 34860 29390656
Ventricular hypokinesia 43.99 10.53 81 148930 4484 29421032
Ischaemic stroke 43.78 10.53 178 148833 15799 29409717
International normalised ratio increased 43.12 10.53 376 148635 43996 29381520
Therapeutic product effect decreased 42.95 10.53 51 148960 29400 29396116
Dyspnoea exertional 42.93 10.53 323 148688 36167 29389349
Therapeutic drug monitoring analysis not performed 42.47 10.53 28 148983 462 29425054
Therapeutic product effect incomplete 42.04 10.53 84 148927 39221 29386295
Naevus flammeus 41.96 10.53 19 148992 140 29425376
Product use issue 40.95 10.53 128 148883 51316 29374200
Inferior vena cava dilatation 40.83 10.53 31 148980 646 29424870
Potentiating drug interaction 40.58 10.53 77 148934 4361 29421155
Drug withdrawal syndrome 40.41 10.53 20 148991 17964 29407552
Sinus bradycardia 39.87 10.53 139 148872 11464 29414052
Erectile dysfunction 39.72 10.53 188 148823 17821 29407695
Palpitations 39.72 10.53 291 148720 32313 29393203
Chest pain 39.64 10.53 788 148223 111185 29314331
Dehydration 39.45 10.53 804 148207 113944 29311572
Respiratory depression 38.96 10.53 10 149001 13513 29412003
Congestive cardiomyopathy 38.76 10.53 96 148915 6534 29418982
Drug resistance 38.71 10.53 31 148980 21509 29404007
Degenerative mitral valve disease 38.63 10.53 20 148991 204 29425312
Hyponatraemic syndrome 38.26 10.53 19 148992 176 29425340
Cardio-respiratory arrest 38.12 10.53 129 148882 50472 29375044
Bundle branch block left 38.08 10.53 83 148928 5194 29420322
Lip oedema 37.86 10.53 51 148960 2153 29423363
COVID-19 37.64 10.53 78 148933 35936 29389580
Bradyarrhythmia 37.29 10.53 48 148963 1937 29423579
Blood creatinine increased 37.17 10.53 619 148392 84483 29341033
Bacteraemia 36.91 10.53 18 148993 16305 29409211
Systolic dysfunction 36.80 10.53 50 148961 2128 29423388
Wrong technique in product usage process 36.40 10.53 64 148947 31364 29394152
Occult blood 36.38 10.53 27 148984 543 29424973
Stomatitis 35.81 10.53 84 148927 37029 29388487
Ventricular tachycardia 35.67 10.53 215 148796 22359 29403157
Adverse drug reaction 35.67 10.53 41 148970 23979 29401537
Hemiparesis 35.50 10.53 156 148855 14330 29411186
N-terminal prohormone brain natriuretic peptide increased 35.18 10.53 46 148965 1886 29423630
Rectal haemorrhage 34.73 10.53 295 148716 34254 29391262
Graft versus host disease 34.54 10.53 4 149007 9624 29415892
Back pain 34.47 10.53 339 148672 101945 29323571
Infusion related reaction 34.36 10.53 110 148901 43776 29381740
Aspergillus infection 34.21 10.53 6 149005 10575 29414941
Pancytopenia 33.61 10.53 263 148748 82905 29342611
Haemodialysis complication 33.60 10.53 14 148997 82 29425434
Bone marrow failure 33.54 10.53 54 148957 27395 29398121
Decreased appetite 33.40 10.53 523 148488 144819 29280697
Deep vein thrombosis 33.37 10.53 162 148849 57237 29368279
Anaemia 33.30 10.53 1282 147729 199669 29225847
Cardiovascular insufficiency 33.21 10.53 38 148973 1355 29424161
Congenital hiatus hernia 32.93 10.53 23 148988 419 29425097
Jaundice 32.61 10.53 256 148755 29040 29396476
Cholestasis 32.45 10.53 216 148795 23246 29402270
Coronary artery stenosis 32.37 10.53 106 148905 8467 29417049
Wound 31.95 10.53 133 148878 11930 29413586
Hemiplegia 31.93 10.53 89 148922 6505 29419011
Blood creatine phosphokinase increased 31.82 10.53 329 148682 40315 29385201
Shone complex 31.80 10.53 13 148998 72 29425444
Pain 31.74 10.53 641 148370 170791 29254725
Neurotoxicity 31.72 10.53 17 148994 14596 29410920
Pulmonary vascular disorder 31.70 10.53 25 148986 552 29424964
Abnormal behaviour 31.69 10.53 42 148969 23085 29402431
Pancreatitis acute 31.64 10.53 221 148790 24164 29401352
Tachyarrhythmia 31.58 10.53 55 148956 2914 29422602
Cerebral haematoma 31.49 10.53 68 148943 4228 29421288
Pharyngeal oedema 31.41 10.53 81 148930 5653 29419863
Atrioventricular block complete 31.10 10.53 100 148911 7911 29417605
Nasopharyngitis 30.99 10.53 175 148836 59490 29366026
Disseminated intravascular coagulation 30.88 10.53 33 148978 19947 29405569
Bronchopulmonary aspergillosis 30.46 10.53 12 148999 12332 29413184
Cytokine release syndrome 30.38 10.53 14 148997 13105 29412411
Drug ineffective for unapproved indication 30.18 10.53 17 148994 14197 29411319
Acute respiratory distress syndrome 30.07 10.53 43 148968 22892 29402624
Pathogen resistance 30.06 10.53 3 149008 8113 29417403
Carotid artery stenosis 29.68 10.53 68 148943 4401 29421115
Infective exacerbation of chronic obstructive airways disease 29.60 10.53 39 148972 1611 29423905
Insomnia 29.56 10.53 295 148716 88466 29337050
Liver disorder 29.08 10.53 60 148951 27689 29397827
Helicobacter gastritis 28.81 10.53 31 148980 1031 29424485
Influenza 28.74 10.53 111 148900 41770 29383746
Haematoma 28.74 10.53 208 148803 23004 29402512
Immune reconstitution inflammatory syndrome 28.60 10.53 3 149008 7799 29417717
Constipation 28.56 10.53 404 148607 113756 29311760
Intentional product misuse 28.46 10.53 85 148926 34576 29390940
Normocytic anaemia 28.16 10.53 42 148969 1950 29423566
Failure to thrive 28.05 10.53 3 149008 7681 29417835
Confusional state 28.03 10.53 843 148168 127034 29298482
Antidepressant drug level above therapeutic 27.92 10.53 15 148996 166 29425350
Thrombocytopenia 27.75 10.53 495 148516 134328 29291188
Aorta hypoplasia 27.64 10.53 12 148999 79 29425437
Aspartate aminotransferase increased 26.95 10.53 183 148828 59542 29365974
Actinic elastosis 26.87 10.53 10 149001 41 29425475
Cardiac septal hypertrophy 26.84 10.53 17 148994 261 29425255
Chronotropic incompetence 26.71 10.53 8 149003 13 29425503
Musculoskeletal pain 26.40 10.53 242 148769 28711 29396805
Adverse event 26.25 10.53 23 148988 15268 29410248
Cold sweat 26.23 10.53 101 148910 8741 29416775
Mouth breathing 25.91 10.53 11 149000 68 29425448
Mucosal haemorrhage 25.83 10.53 35 148976 1486 29424030
Pharyngeal swelling 25.65 10.53 35 148976 1496 29424020
Blood pressure increased 25.63 10.53 518 148493 73285 29352231
Injection site pain 25.62 10.53 81 148930 32365 29393151
Basilar artery thrombosis 25.37 10.53 14 148997 164 29425352
Diabetic foetopathy 25.31 10.53 15 148996 203 29425313
Nephroangiosclerosis 25.30 10.53 14 148997 165 29425351
Respiratory arrest 25.29 10.53 58 148953 25775 29399741
Vertebral osteophyte 25.29 10.53 10 149001 50 29425466
Exposure during pregnancy 25.27 10.53 6 149005 8548 29416968
Low density lipoprotein abnormal 25.24 10.53 16 148995 246 29425270
Seizure 24.93 10.53 325 148686 92798 29332718
Electrocardiogram Q wave abnormal 24.90 10.53 17 148994 298 29425218
Blood pressure diastolic decreased 24.89 10.53 85 148926 6937 29418579
Dermatitis allergic 24.86 10.53 74 148937 5614 29419902
Ocular myasthenia 24.81 10.53 15 148996 211 29425305
Cranial sutures widening 24.77 10.53 11 149000 77 29425439
Hypoaesthesia eye 24.44 10.53 8 149003 20 29425496
Nicotine dependence 24.42 10.53 20 148991 467 29425049
Carotid arteriosclerosis 24.28 10.53 33 148978 1405 29424111
Post procedural haematoma 24.23 10.53 33 148978 1408 29424108
Thrombosis 24.15 10.53 123 148888 42922 29382594
Cardiac aneurysm 24.09 10.53 25 148986 797 29424719
Laboratory test abnormal 23.93 10.53 34 148977 18151 29407365
Blood pressure systolic decreased 23.90 10.53 57 148954 3787 29421729
Infection 23.55 10.53 260 148751 76491 29349025
Mouth swelling 23.39 10.53 34 148977 1542 29423974
Brain scan abnormal 23.39 10.53 25 148986 825 29424691
Vasculitic rash 23.13 10.53 25 148986 836 29424680
Depressed mood 23.09 10.53 152 148859 16296 29409220
Pancreatitis necrotising 23.06 10.53 42 148969 2305 29423211
Analgesic drug level above therapeutic 22.99 10.53 15 148996 243 29425273
Immune-mediated myositis 22.95 10.53 34 148977 1569 29423947
Angina unstable 22.93 10.53 112 148899 10753 29414763
Helicobacter test positive 22.84 10.53 22 148989 640 29424876
Anxiety 22.82 10.53 298 148713 85067 29340449
Cough 22.76 10.53 816 148195 125911 29299605
Sinus arrest 22.63 10.53 32 148979 1415 29424101
Supravalvular aortic stenosis 22.60 10.53 9 149002 46 29425470
Cerebral artery thrombosis 22.53 10.53 23 148988 719 29424797
Gastritis erosive 22.48 10.53 69 148942 5324 29420192
Pneumocystis jirovecii pneumonia 22.45 10.53 31 148980 16748 29408768
Mitral valve disease 22.33 10.53 29 148982 1181 29424335
Medication error 22.32 10.53 183 148828 21028 29404488
Mucosal inflammation 22.16 10.53 83 148928 31512 29394004
Gamma-glutamyltransferase increased 22.15 10.53 219 148792 26518 29398998
Euglycaemic diabetic ketoacidosis 22.06 10.53 44 148967 2586 29422930
Pemphigoid 22.00 10.53 86 148925 7495 29418021
Eye injury 22.00 10.53 21 148990 604 29424912
Therapeutic response unexpected 21.98 10.53 8 149003 8630 29416886
Oral neoplasm 21.85 10.53 8 149003 31 29425485
Polyuria 21.76 10.53 84 148927 7278 29418238
Cytomegalovirus viraemia 21.76 10.53 3 149008 6317 29419199
No adverse event 21.72 10.53 34 148977 17444 29408072
Rales 21.64 10.53 85 148926 7425 29418091
Blood potassium increased 21.55 10.53 137 148874 14514 29411002
Left atrial dilatation 21.55 10.53 34 148977 1659 29423857
Hypertrophy 21.53 10.53 18 148993 433 29425083
Upper motor neurone lesion 21.52 10.53 11 149000 109 29425407
Akathisia 21.42 10.53 4 149007 6738 29418778
Tendon rupture 21.27 10.53 75 148936 6220 29419296
Hypersomnia 21.24 10.53 14 148997 10740 29414776
Haematotoxicity 21.23 10.53 4 149007 6695 29418821
Patent ductus arteriosus 21.19 10.53 48 148963 3083 29422433
Carcinogenicity 21.15 10.53 9 149002 56 29425460
Mucosal dryness 21.11 10.53 26 148985 1003 29424513
Myositis 20.99 10.53 105 148906 10178 29415338
Therapy interrupted 20.94 10.53 8 149003 8378 29417138
Eczema nummular 20.77 10.53 11 149000 118 29425398
Hiatus hernia 20.75 10.53 78 148933 6674 29418842
Camptocormia 20.73 10.53 12 148999 155 29425361
Jealous delusion 20.67 10.53 13 148998 197 29425319
Cytopenia 20.63 10.53 12 148999 9847 29415669
Type 2 diabetes mellitus 20.60 10.53 128 148883 13453 29412063
Pneumonia aspiration 20.59 10.53 105 148906 36632 29388884
Orthopnoea 20.58 10.53 60 148951 4500 29421016
Mitral valve hypoplasia 20.56 10.53 8 149003 38 29425478
Contraindicated product administered 20.53 10.53 160 148851 18106 29407410
Diabetic ketoacidosis 20.46 10.53 145 148866 15928 29409588
Cardiogenic shock 20.43 10.53 166 148845 19024 29406492
Dysarthria 20.42 10.53 242 148769 30669 29394847
Staphylococcal infection 20.38 10.53 77 148934 29163 29396353
Abnormal weight gain 20.38 10.53 24 148987 883 29424633
Duodenal ulcer perforation 20.22 10.53 31 148980 1475 29424041
Epiglottic oedema 20.21 10.53 12 148999 163 29425353
Macrophages increased 20.21 10.53 12 148999 163 29425353
Duodenitis 20.21 10.53 56 148955 4079 29421437
Phalangeal hypoplasia 20.15 10.53 9 149002 64 29425452
Heart rate decreased 20.13 10.53 203 148808 24709 29400807
Hypercholesterolaemia 20.11 10.53 81 148930 7157 29418359
Loss of proprioception 20.11 10.53 16 148995 358 29425158
Swelling face 20.05 10.53 173 148838 20177 29405339
Foetal exposure during pregnancy 20.02 10.53 95 148916 33772 29391744
Unevaluable event 19.92 10.53 80 148931 29771 29395745
Systemic infection 19.89 10.53 37 148974 2064 29423452
Ascites 19.78 10.53 106 148905 36513 29389003
Discharge 19.72 10.53 12 148999 171 29425345
Encephalopathy 19.59 10.53 85 148926 30958 29394558
Hypoalbuminaemia 19.58 10.53 14 148997 10291 29415225
Interstitial lung disease 19.55 10.53 191 148820 57527 29367989
Appendicitis 19.37 10.53 10 149001 8769 29416747
Stenosis 19.29 10.53 25 148986 1016 29424500
Fatigue 19.27 10.53 1356 147655 315465 29110051
Laryngeal cleft 19.24 10.53 6 149005 12 29425504
Therapy cessation 19.07 10.53 27 148984 14435 29411081
Ventricular enlargement 19.07 10.53 17 148994 447 29425069
Loss of personal independence in daily activities 19.06 10.53 65 148946 25375 29400141
Haemophagocytic lymphohistiocytosis 19.02 10.53 15 148996 10489 29415027
Band neutrophil percentage decreased 18.92 10.53 6 149005 13 29425503
Epstein-Barr virus infection 18.91 10.53 5 149006 6624 29418892
Pneumonia bacterial 18.68 10.53 12 148999 9331 29416185
Blood pressure systolic increased 18.63 10.53 147 148864 16698 29408818
Gastrointestinal disorder 18.49 10.53 78 148933 28628 29396888
Anuria 18.48 10.53 96 148915 9445 29416071
Vocal cord inflammation 18.38 10.53 8 149003 53 29425463
Hyperthyroidism 18.36 10.53 89 148922 8519 29416997
Myocardial ischaemia 18.35 10.53 141 148870 15887 29409629
Type V hyperlipidaemia 18.31 10.53 20 148991 677 29424839
Melanoderma 18.24 10.53 11 149000 154 29425362
Product storage error 18.23 10.53 5 149006 6465 29419051
Cerebrovascular accident 18.20 10.53 512 148499 76399 29349117
Genital herpes simplex 17.98 10.53 10 149001 119 29425397
Full blood count abnormal 17.91 10.53 30 148981 14983 29410533
Precancerous skin lesion 17.86 10.53 18 148993 554 29424962
Pulmonary alveolar haemorrhage 17.84 10.53 5 149006 6375 29419141
Fracture displacement 17.78 10.53 8 149003 58 29425458
Xyphoid retraction 17.76 10.53 11 149000 162 29425354
Heart rate irregular 17.68 10.53 120 148891 12997 29412519
Arterial spasm 17.45 10.53 9 149002 91 29425425
Gastritis haemorrhagic 17.27 10.53 26 148985 1217 29424299
Septic shock 17.23 10.53 217 148794 62343 29363173
Arthralgia 17.21 10.53 554 148457 139063 29286453
Sudden cardiac death 17.12 10.53 45 148966 3177 29422339
Bleeding time prolonged 16.99 10.53 18 148993 588 29424928
Diabetes mellitus inadequate control 16.95 10.53 112 148899 12022 29413494
Nephrotic syndrome 16.94 10.53 70 148941 6258 29419258
Face oedema 16.92 10.53 99 148912 10184 29415332
Transplant rejection 16.87 10.53 13 148998 9199 29416317
Oxygen consumption decreased 16.87 10.53 11 149000 178 29425338
Nocturia 16.80 10.53 85 148926 8277 29417239
Injection site reaction 16.71 10.53 19 148992 11169 29414347
Lichenoid keratosis 16.66 10.53 35 148976 2135 29423381
Erysipelas 16.64 10.53 53 148958 4172 29421344
Trigger finger 16.61 10.53 19 148992 677 29424839
Muscle enzyme increased 16.53 10.53 12 148999 233 29425283
Oesophageal discomfort 16.52 10.53 7 149004 43 29425473
Neoplasm progression 16.49 10.53 44 148967 18568 29406948
Dry skin 16.49 10.53 61 148950 23246 29402270
Metabolic acidosis 16.44 10.53 274 148737 37388 29388128
Perineal pain 16.43 10.53 20 148991 762 29424754
Foetal disorder 16.41 10.53 20 148991 763 29424753
Arteriosclerotic gangrene 16.40 10.53 8 149003 71 29425445
Akinesia 16.34 10.53 33 148978 1957 29423559
Granulocytopenia 16.21 10.53 5 149006 5989 29419527
Chills 16.20 10.53 257 148754 71043 29354473
Obstructive pancreatitis 16.19 10.53 15 148996 415 29425101
Monoparesis 16.16 10.53 32 148979 1871 29423645
Respiratory tract haemorrhage 16.09 10.53 22 148989 942 29424574
Low cardiac output syndrome 16.07 10.53 16 148995 485 29425031
Intracranial haematoma 15.96 10.53 14 148997 360 29425156
Left ventricular enlargement 15.90 10.53 18 148993 634 29424882
Allergy to animal 15.89 10.53 12 148999 248 29425268
Carcinoma in situ of skin 15.85 10.53 8 149003 77 29425439
Cellulitis 15.81 10.53 151 148860 45689 29379827
Underdose 15.81 10.53 22 148989 11847 29413669
Post-traumatic amnestic disorder 15.76 10.53 7 149004 49 29425467
Transient ischaemic attack 15.73 10.53 183 148828 23087 29402429
Faeces pale 15.63 10.53 25 148986 1234 29424282
Diarrhoea 15.61 10.53 1454 147557 331244 29094272
Blood pressure inadequately controlled 15.51 10.53 36 148975 2350 29423166
Upper respiratory tract infection 15.42 10.53 78 148933 27271 29398245
Therapeutic response decreased 15.39 10.53 68 148943 24643 29400873
Gingival hypertrophy 15.36 10.53 29 148982 1636 29423880
Multiple organ dysfunction syndrome 15.19 10.53 225 148786 62891 29362625
Dystonia 15.18 10.53 16 148995 9733 29415783
Diastolic dysfunction 15.15 10.53 58 148953 5006 29420510
Blood product transfusion dependent 15.13 10.53 13 148998 325 29425191
Oedema mouth 15.12 10.53 24 148987 1177 29424339
Progressive multifocal leukoencephalopathy 15.10 10.53 13 148998 8706 29416810
Pulmonary fibrosis 15.10 10.53 132 148879 15450 29410066
Congenital heart valve disorder 15.08 10.53 7 149004 55 29425461
Myelosuppression 14.99 10.53 24 148987 12203 29413313
Colitis 14.97 10.53 94 148917 31154 29394362
Intrapericardial thrombosis 14.97 10.53 7 149004 56 29425460
Derailment 14.96 10.53 4 149007 3 29425513
Peripheral pulse decreased 14.96 10.53 4 149007 3 29425513
Resuscitation 14.96 10.53 24 148987 1188 29424328
Intervertebral disc displacement 14.86 10.53 9 149002 127 29425389
Hyperammonaemia 14.83 10.53 5 149006 5658 29419858
Brain natriuretic peptide increased 14.81 10.53 51 148960 4179 29421337
Raynaud's phenomenon 14.80 10.53 12 148999 276 29425240
Injection site erythema 14.77 10.53 30 148981 13926 29411590
Atrioventricular block 14.75 10.53 72 148939 6910 29418606
Therapy partial responder 14.68 10.53 4 149007 5195 29420321
Haematemesis 14.63 10.53 189 148822 24437 29401079
Vitamin B12 decreased 14.61 10.53 22 148989 1030 29424486
Pseudomonas infection 14.57 10.53 20 148991 10832 29414684
Surgery 14.55 10.53 23 148988 11756 29413760
Right ventricular enlargement 14.47 10.53 10 149001 179 29425337
Ventricular tachyarrhythmia 14.44 10.53 12 148999 286 29425230
Bacterial infection 14.42 10.53 27 148984 12921 29412595
Atrial septal defect 14.34 10.53 70 148941 6719 29418797
Clostridium difficile colitis 14.33 10.53 28 148983 13184 29412332
Nasal congestion 14.30 10.53 48 148963 18831 29406685
Accidental exposure to product 14.25 10.53 20 148991 10733 29414783
Tongue disorder 14.20 10.53 3 149008 4633 29420883
Hypogammaglobulinaemia 14.16 10.53 6 149005 5901 29419615
Neutropenia neonatal 14.13 10.53 17 148994 640 29424876
Ischaemia 14.07 10.53 50 148961 4162 29421354
Sinoatrial block 14.02 10.53 14 148997 426 29425090
Glomerular filtration rate abnormal 13.99 10.53 18 148993 726 29424790
Cardiac output decreased 13.98 10.53 19 148992 809 29424707
Thyroiditis acute 13.91 10.53 8 149003 102 29425414
Accessory spleen 13.89 10.53 9 149002 144 29425372
Malnutrition 13.86 10.53 21 148990 10920 29414596
Eczema 13.86 10.53 118 148893 13708 29411808
Neonatal respiratory distress 13.84 10.53 15 148996 503 29425013
Glomerulonephritis acute 13.81 10.53 7 149004 68 29425448
Cutaneous vasculitis 13.80 10.53 42 148969 3226 29422290
Irritability 13.77 10.53 61 148950 22091 29403425
Dyspnoea paroxysmal nocturnal 13.77 10.53 25 148986 1369 29424147
Venous pressure jugular decreased 13.63 10.53 6 149005 41 29425475
C-reactive protein abnormal 13.61 10.53 8 149003 6528 29418988
Liver function test abnormal 13.60 10.53 213 148798 28705 29396811
Electrocardiogram ambulatory abnormal 13.55 10.53 4 149007 6 29425510
Pleural effusion 13.53 10.53 268 148743 71640 29353876
Coronary artery bypass 13.48 10.53 53 148958 4632 29420884
Enlarged uvula 13.47 10.53 9 149002 152 29425364
Brain stem infarction 13.43 10.53 22 148989 1108 29424408
Mitral valve calcification 13.42 10.53 15 148996 521 29424995
Oliguria 13.28 10.53 73 148938 7339 29418177
Malaise 13.24 10.53 954 148057 158648 29266868
Base excess decreased 13.19 10.53 10 149001 208 29425308
Peritonitis 13.17 10.53 35 148976 14789 29410727
Vascular access site occlusion 13.16 10.53 6 149005 45 29425471
Feeling abnormal 13.13 10.53 194 148817 54251 29371265
Euphoric mood 13.09 10.53 4 149007 4821 29420695
Basal ganglia haemorrhage 13.04 10.53 18 148993 778 29424738
Agitation 13.01 10.53 181 148830 51123 29374393
Cerebral calcification 12.99 10.53 7 149004 78 29425438
Necrotising myositis 12.98 10.53 14 148997 467 29425049
Large for dates baby 12.97 10.53 19 148992 868 29424648
Headache 12.92 10.53 731 148280 173276 29252240
Breast hyperplasia 12.89 10.53 3 149008 0 29425516
Delusion 12.84 10.53 23 148988 11193 29414323
Arterial intramural haematoma 12.83 10.53 6 149005 48 29425468
Gout 12.81 10.53 136 148875 16775 29408741
Compartment syndrome 12.78 10.53 34 148977 2418 29423098
Illness 12.77 10.53 9 149002 6665 29418851
Subclavian artery occlusion 12.73 10.53 8 149003 121 29425395
Paraesthesia oral 12.70 10.53 43 148968 3494 29422022
Congenital aortic anomaly 12.68 10.53 7 149004 82 29425434
Lymphocyte count decreased 12.63 10.53 52 148959 19219 29406297
Facial bones fracture 12.60 10.53 33 148978 2324 29423192
BK virus infection 12.60 10.53 4 149007 4703 29420813
Prostatic haemorrhage 12.60 10.53 10 149001 223 29425293
Ischaemic cardiomyopathy 12.53 10.53 59 148952 5579 29419937
Sex hormone binding globulin increased 12.51 10.53 4 149007 9 29425507
Strangury 12.40 10.53 8 149003 127 29425389
Pulmonary thrombosis 12.37 10.53 9 149002 6556 29418960
Thirst 12.36 10.53 65 148946 6426 29419090
Oesophageal perforation 12.26 10.53 17 148994 738 29424778
Palmar-plantar erythrodysaesthesia syndrome 12.25 10.53 36 148975 14723 29410793
Abdominal pain lower 12.23 10.53 80 148931 8558 29416958
Fasciotomy 12.22 10.53 4 149007 10 29425506
Altered state of consciousness 12.22 10.53 55 148956 19834 29405682
Embolic stroke 12.22 10.53 43 148968 3563 29421953
Tumour lysis syndrome 12.17 10.53 33 148978 13851 29411665
Mitral valve thickening 12.13 10.53 12 148999 361 29425155
Arthritis 12.12 10.53 75 148936 24944 29400572
Migraine 12.09 10.53 28 148983 12402 29413114
Necrotising retinitis 12.03 10.53 17 148994 751 29424765
Hydrothorax 12.02 10.53 13 148998 435 29425081
Left ventricular hypertrophy 12.00 10.53 66 148945 6637 29418879
Blood creatine phosphokinase MB increased 11.96 10.53 27 148984 1730 29423786
Intraventricular haemorrhage 11.94 10.53 37 148974 2869 29422647
Urticarial vasculitis 11.90 10.53 5 149006 30 29425486
Epistaxis 11.89 10.53 343 148668 51361 29374155
Faeces discoloured 11.87 10.53 111 148900 13240 29412276
Arthropathy 11.85 10.53 62 148949 21492 29404024
Device issue 11.85 10.53 13 148998 7767 29417749
Hot flush 11.82 10.53 37 148974 14833 29410683
Atrial thrombosis 11.80 10.53 29 148982 1964 29423552
Echocardiogram abnormal 11.79 10.53 18 148993 853 29424663
Haemarthrosis 11.79 10.53 36 148975 2770 29422746
Acute stress disorder 11.78 10.53 8 149003 139 29425377
Benign prostatic hyperplasia 11.77 10.53 100 148911 11610 29413906
N-terminal prohormone brain natriuretic peptide abnormal 11.75 10.53 9 149002 190 29425326
Angiocardiogram 11.71 10.53 9 149002 191 29425325
Osteomyelitis 11.70 10.53 33 148978 13676 29411840
Lividity 11.68 10.53 8 149003 141 29425375
Myelodysplastic syndrome 11.67 10.53 48 148963 17746 29407770
Pyelitis 11.67 10.53 7 149004 97 29425419
Implant site extravasation 11.63 10.53 12 148999 380 29425136
Oropharyngeal swelling 11.62 10.53 13 148998 452 29425064
Ventricular internal diameter abnormal 11.61 10.53 7 149004 98 29425418
Oxygen saturation decreased 11.59 10.53 158 148853 44779 29380737
Tardive dyskinesia 11.58 10.53 6 149005 5252 29420264
Clostridium difficile infection 11.58 10.53 42 148969 16099 29409417
Ammonia increased 11.57 10.53 3 149008 4028 29421488
Thalamic infarction 11.56 10.53 15 148996 610 29424906
Back disorder 11.50 10.53 8 149003 5965 29419551
Immunodeficiency 11.49 10.53 4 149007 4436 29421080
Cystitis haemorrhagic 11.47 10.53 5 149006 4837 29420679
Sinus rhythm 11.47 10.53 10 149001 255 29425261
Fibrinolysis increased 11.46 10.53 4 149007 13 29425503
Gastric ulcer haemorrhage 11.35 10.53 52 148959 4862 29420654
Left ventricular failure 11.32 10.53 50 148961 4603 29420913
Product administration error 11.27 10.53 116 148895 14194 29411322
Venous pressure jugular increased 11.22 10.53 16 148995 713 29424803
Osteonecrosis 11.21 10.53 33 148978 13486 29412030
Implant site inflammation 11.19 10.53 7 149004 105 29425411
Hypersensitivity vasculitis 11.17 10.53 39 148972 3218 29422298
Oesophageal infection 11.06 10.53 10 149001 268 29425248
Blood ethanol increased 11.04 10.53 13 148998 478 29425038
Electrocardiogram QRS complex shortened 11.03 10.53 8 149003 155 29425361
Actinic keratosis 11.03 10.53 43 148968 3743 29421773
Mean cell haemoglobin concentration 11.02 10.53 5 149006 37 29425479
Device related infection 11.01 10.53 41 148970 15595 29409921
Poisoning 10.99 10.53 21 148990 9972 29415544
Dermatitis exfoliative generalised 10.96 10.53 36 148975 2880 29422636
Neuroleptic malignant syndrome 10.95 10.53 43 148968 16105 29409411
Psychotic disorder 10.94 10.53 59 148952 20295 29405221
Fluid intake reduced 10.91 10.53 36 148975 2886 29422630
Alanine aminotransferase increased 10.89 10.53 273 148738 70671 29354845
Acute respiratory failure 10.88 10.53 83 148928 26319 29399197
Gastrointestinal mucosal necrosis 10.82 10.53 8 149003 160 29425356
Megakaryocytes increased 10.80 10.53 5 149006 39 29425477
Skin swelling 10.74 10.53 19 148992 1019 29424497
Mean cell volume abnormal 10.72 10.53 10 149001 279 29425237
Blood osmolarity increased 10.72 10.53 11 149000 346 29425170
Posterior reversible encephalopathy syndrome 10.65 10.53 18 148993 8958 29416558
Epiglottitis 10.64 10.53 11 149000 349 29425167
Pulmonary haemorrhage 10.62 10.53 19 148992 9251 29416265
Drug reaction with eosinophilia and systemic symptoms 10.62 10.53 90 148921 27902 29397614
Hypernatraemia 10.54 10.53 13 148998 7373 29418143

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 1438.71 10.04 4533 256684 444707 63792808
Hyperkalaemia 930.32 10.04 1554 259663 99575 64137940
General physical health deterioration 761.07 10.04 2179 259038 202246 64035269
Angioedema 650.18 10.04 1010 260207 60811 64176704
Bradycardia 541.15 10.04 1361 259856 116858 64120657
Drug interaction 532.14 10.04 2877 258340 359206 63878309
Hyponatraemia 526.36 10.04 1555 259662 146784 64090731
Completed suicide 523.34 10.04 132 261085 224282 64013233
Syncope 516.70 10.04 1607 259610 156028 64081487
Drug ineffective 508.67 10.04 1729 259488 838518 63398997
Hypotension 465.07 10.04 2882 258335 378092 63859423
Hypertensive crisis 464.46 10.04 465 260752 17783 64219732
Product prescribing error 434.91 10.04 621 260596 34648 64202867
Death 427.62 10.04 817 260400 481888 63755627
Cardiac failure 330.97 10.04 1233 259984 131140 64106375
Lactic acidosis 328.14 10.04 751 260466 60659 64176856
Off label use 303.94 10.04 1425 259792 631381 63606134
Product dose omission issue 294.90 10.04 215 261002 194532 64042983
Swollen tongue 291.92 10.04 515 260702 34439 64203076
Presyncope 262.60 10.04 493 260724 34596 64202919
Angina pectoris 238.25 10.04 549 260668 44532 64192983
Hypoglycaemia 236.10 10.04 851 260366 89041 64148474
Atrial fibrillation 234.18 10.04 1335 259882 169754 64067761
Myocardial infarction 225.70 10.04 1292 259925 164529 64072986
Lip swelling 211.57 10.04 426 260791 31481 64206034
Dizziness 209.08 10.04 2659 258558 427504 63810011
Pain 204.55 10.04 1358 259859 552153 63685362
Dehydration 199.19 10.04 1531 259686 215232 64022283
Sopor 195.46 10.04 395 260822 29266 64208249
Fall 190.95 10.04 2549 258668 414277 63823238
Febrile neutropenia 188.15 10.04 293 260924 187364 64050151
White blood cell count decreased 181.72 10.04 223 260994 157614 64079901
Melaena 180.80 10.04 552 260665 52996 64184519
Confusional state 180.32 10.04 1731 259486 259413 63978102
Acute myocardial infarction 177.94 10.04 654 260563 69064 64168451
Orthostatic hypotension 172.24 10.04 497 260720 46241 64191274
Tongue oedema 171.80 10.04 163 261054 5827 64231688
Product monitoring error 171.07 10.04 156 261061 5298 64232217
Haematochezia 167.19 10.04 620 260597 65753 64171762
Rhabdomyolysis 160.84 10.04 767 260450 90959 64146556
Drug hypersensitivity 159.29 10.04 466 260751 237349 64000166
Sinusitis 158.87 10.04 215 261002 145713 64091802
Dyspnoea 153.41 10.04 3899 257318 714775 63522740
Toxicity to various agents 151.69 10.04 858 260359 362655 63874860
Electrolyte imbalance 150.91 10.04 323 260894 24920 64212595
Circulatory collapse 142.41 10.04 377 260840 33355 64204160
Platelet count decreased 139.32 10.04 294 260923 167417 64070098
Pallor 138.67 10.04 408 260809 38373 64199142
Coronary artery disease 136.22 10.04 545 260672 59888 64177627
Labelled drug-drug interaction medication error 135.00 10.04 285 260932 21777 64215738
Pyrexia 133.42 10.04 1534 259683 557110 63680405
Pneumonia 131.91 10.04 1541 259676 558035 63679480
Synovitis 131.83 10.04 124 261093 98966 64138549
Maternal exposure during pregnancy 127.54 10.04 120 261097 95764 64141751
Ejection fraction decreased 126.47 10.04 326 260891 28381 64209134
Injection site pain 124.45 10.04 161 261056 111247 64126268
Disease progression 123.95 10.04 241 260976 141439 64096076
Arrhythmia 122.17 10.04 481 260736 52463 64185052
International normalised ratio increased 120.43 10.04 636 260581 78531 64158984
Arthropathy 110.00 10.04 201 261016 120766 64116749
Hospitalisation 108.66 10.04 87 261130 75120 64162395
Injection site erythema 108.59 10.04 77 261140 70723 64166792
Treatment failure 108.10 10.04 192 261025 116624 64120891
Infusion related reaction 107.37 10.04 326 260891 164141 64073374
Product use in unapproved indication 104.96 10.04 365 260852 176253 64061262
Neutropenia 103.99 10.04 558 260659 239066 63998449
Abdominal discomfort 102.91 10.04 385 260832 181937 64055578
Jaundice 102.60 10.04 429 260788 48083 64189432
Therapeutic product effect decreased 99.34 10.04 198 261019 115153 64122362
Acute coronary syndrome 98.53 10.04 232 260985 19078 64218437
Infection 98.21 10.04 400 260817 184480 64053035
Stomatitis 97.99 10.04 184 261033 109421 64128094
Electrocardiogram abnormal 97.85 10.04 187 261030 13294 64224221
Ischaemic stroke 97.69 10.04 299 260918 28736 64208779
Alopecia 97.39 10.04 344 260873 165346 64072169
Anaemia 95.55 10.04 2104 259113 376576 63860939
Product use issue 95.30 10.04 306 260911 151409 64086106
Exposure during pregnancy 94.45 10.04 105 261112 77570 64159945
Drug intolerance 94.15 10.04 416 260801 187576 64049939
Loss of consciousness 93.29 10.04 965 260252 147400 64090115
Systemic lupus erythematosus 93.19 10.04 106 261111 77506 64160009
Oedema peripheral 92.65 10.04 1278 259939 209039 64028476
Haematuria 91.41 10.04 485 260732 59986 64177529
Neuropathy peripheral 91.04 10.04 214 261003 117311 64120204
Wrong technique in product usage process 90.36 10.04 78 261139 64896 64172619
Glomerular filtration rate decreased 90.09 10.04 226 260991 19346 64218169
Rash 89.45 10.04 1313 259904 457236 63780279
Cardiac failure chronic 87.10 10.04 142 261075 8899 64228616
Cerebral haemorrhage 85.77 10.04 422 260795 50668 64186847
Haematemesis 83.07 10.04 394 260823 46605 64190910
Therapeutic product effect incomplete 82.10 10.04 186 261031 103296 64134219
Blood pressure increased 81.11 10.04 1061 260156 171491 64066024
Rectal haemorrhage 80.30 10.04 476 260741 61341 64176174
Mitral valve incompetence 79.49 10.04 256 260961 25282 64212233
Blood creatine phosphokinase increased 79.37 10.04 456 260761 58102 64179413
Left ventricular dysfunction 79.33 10.04 197 261020 16757 64220758
Bradyarrhythmia 78.16 10.04 86 261131 3672 64233843
Sleep disorder due to general medical condition, insomnia type 77.71 10.04 8 261209 26262 64211253
Pemphigus 77.21 10.04 79 261138 60622 64176893
Neutrophil count decreased 76.85 10.04 121 261096 77075 64160440
Blood creatinine increased 73.33 10.04 857 260360 134925 64102590
Therapeutic drug monitoring analysis not performed 73.30 10.04 51 261166 1161 64236354
Device expulsion 72.56 10.04 3 261214 21133 64216382
Chest pain 72.31 10.04 1350 259867 234630 64002885
Nasopharyngitis 72.14 10.04 481 260736 195592 64041923
Glossodynia 71.71 10.04 94 261123 64602 64172913
Injection site pruritus 71.11 10.04 32 261185 37794 64199721
Cytomegalovirus infection 70.67 10.04 31 261186 37168 64200347
Pancreatitis acute 70.52 10.04 352 260865 42503 64195012
Ventricular arrhythmia 68.12 10.04 114 261103 7301 64230214
Hepatojugular reflux 67.85 10.04 36 261181 491 64237024
Arthralgia 67.76 10.04 1323 259894 440937 63796578
Haematoma 67.21 10.04 367 260850 45883 64191632
Lip oedema 66.35 10.04 93 261124 5096 64232419
Erectile dysfunction 65.83 10.04 153 261064 12474 64225041
Respiratory arrest 65.10 10.04 71 261146 52914 64184601
Exercise tolerance decreased 64.87 10.04 114 261103 7596 64229919
Hepatic function abnormal 64.78 10.04 100 261117 64213 64173302
Bundle branch block left 64.17 10.04 132 261085 9902 64227613
Malignant neoplasm progression 63.23 10.04 239 260978 112632 64124883
Hypoxia 63.19 10.04 167 261050 87982 64149533
Medication error 63.13 10.04 382 260835 49584 64187931
Migraine 62.62 10.04 98 261119 62579 64174936
Anti-cyclic citrullinated peptide antibody positive 62.47 10.04 65 261152 49497 64188018
Palatal oedema 60.12 10.04 45 261172 1152 64236363
Hand deformity 60.03 10.04 101 261116 62670 64174845
Cardio-respiratory arrest 60.00 10.04 201 261016 98192 64139323
Respiratory failure 59.48 10.04 395 260822 160788 64076727
Swelling 59.44 10.04 392 260825 159826 64077689
Vertigo 59.29 10.04 426 260791 58585 64178930
Injection site reaction 59.04 10.04 61 261156 46603 64190912
Mental status changes 58.87 10.04 98 261119 61064 64176451
Cholestasis 58.58 10.04 346 260871 44526 64192989
Drug abuse 56.95 10.04 309 260908 132065 64105450
Pemphigoid 56.70 10.04 147 261070 12839 64224676
Naevus flammeus 56.69 10.04 19 261198 70 64237445
Influenza 56.21 10.04 231 260986 106300 64131215
Congestive cardiomyopathy 55.76 10.04 127 261090 10217 64227298
Hemiparesis 55.61 10.04 254 260963 29573 64207942
Angina unstable 55.54 10.04 163 261054 15304 64222211
Anuria 55.34 10.04 186 261031 18778 64218737
Hypersensitivity 55.04 10.04 519 260698 195933 64041582
Tachyarrhythmia 54.50 10.04 92 261125 5934 64231581
Drug ineffective for unapproved indication 54.49 10.04 29 261188 31104 64206411
Respiratory depression 54.16 10.04 14 261203 23429 64214086
Computerised tomogram coronary artery abnormal 53.90 10.04 23 261194 185 64237330
Gastrointestinal disorder 53.52 10.04 185 261032 89524 64147991
Flushing 52.66 10.04 154 261063 78494 64159021
Renin increased 52.27 10.04 23 261194 201 64237314
Sinus bradycardia 52.00 10.04 207 261010 22686 64214829
Urogenital haemorrhage 51.71 10.04 33 261184 647 64236868
Renal failure 51.06 10.04 1026 260191 180662 64056853
Pancreatitis necrotising 50.90 10.04 64 261153 3153 64234362
Irritable bowel syndrome 50.58 10.04 46 261171 37323 64200192
Renal impairment 50.58 10.04 798 260419 134219 64103296
Headache 50.20 10.04 1699 259518 527768 63709747
Cardiovascular insufficiency 49.37 10.04 57 261160 2567 64234948
COVID-19 49.32 10.04 120 261097 65020 64172495
Upper respiratory tract infection 49.11 10.04 142 261075 72643 64164872
Systemic infection 48.77 10.04 73 261144 4248 64233267
Asthenia 48.74 10.04 2159 259058 425885 63811630
Hyponatraemic syndrome 48.25 10.04 33 261184 730 64236785
Therapy interrupted 48.17 10.04 11 261206 20025 64217490
Myalgia 48.05 10.04 906 260311 157711 64079804
Basilar artery thrombosis 48.00 10.04 24 261193 287 64237228
Fatigue 47.96 10.04 2512 258705 746218 63491297
Drug resistance 47.76 10.04 43 261174 35059 64202456
Back pain 47.74 10.04 719 260498 249452 63988063
Bacteraemia 47.19 10.04 25 261192 26886 64210629
Atrioventricular block complete 47.13 10.04 147 261070 14271 64223244
Intentional product misuse 46.65 10.04 144 261073 72151 64165364
Mucosal dryness 46.37 10.04 59 261158 2942 64234573
Abortion spontaneous 46.13 10.04 22 261195 25121 64212394
Pericarditis 44.38 10.04 119 261098 62397 64175118
Therapy cessation 43.97 10.04 40 261177 32449 64205066
Injection site swelling 43.89 10.04 62 261155 41291 64196224
Coronary artery stenosis 43.75 10.04 122 261095 11126 64226389
Liver function test abnormal 43.49 10.04 399 260818 59002 64178513
Plasma cell myeloma 43.26 10.04 75 261142 46000 64191515
Potentiating drug interaction 42.99 10.04 97 261120 7755 64229760
Drug withdrawal syndrome 42.97 10.04 38 261179 31253 64206262
Cerebrovascular accident 42.75 10.04 789 260428 136794 64100721
Atrioventricular block 42.55 10.04 126 261091 11889 64225626
Dysarthria 42.47 10.04 397 260820 59009 64178506
Neurotoxicity 41.75 10.04 30 261187 27374 64210141
Inferior vena cava dilatation 41.60 10.04 30 261187 724 64236791
Surgery 41.55 10.04 32 261185 28181 64209334
Dyspnoea at rest 41.34 10.04 84 261133 6245 64231270
Device issue 41.27 10.04 20 261197 22628 64214887
Swelling face 41.10 10.04 393 260824 58773 64178742
Ventricular tachycardia 40.79 10.04 258 260959 34007 64203508
Cerebral haematoma 40.73 10.04 90 261127 7095 64230420
Atrioventricular block first degree 40.36 10.04 115 261102 10619 64226896
Degenerative mitral valve disease 40.16 10.04 20 261197 237 64237278
Diabetes mellitus inadequate control 40.07 10.04 182 261035 21139 64216376
Joint swelling 40.06 10.04 622 260595 214760 64022755
Diabetic metabolic decompensation 39.60 10.04 52 261165 2676 64234839
Gastritis erosive 39.24 10.04 106 261111 9489 64228026
Transplant rejection 39.05 10.04 11 261206 17390 64220125
Gamma-glutamyltransferase increased 38.69 10.04 332 260885 48178 64189337
Asphyxia 38.44 10.04 105 261112 9461 64228054
Ill-defined disorder 38.44 10.04 75 261142 43977 64193538
Drug dependence 38.37 10.04 47 261170 33265 64204250
Blood creatine increased 38.13 10.04 95 261122 8097 64229418
Palpitations 37.78 10.04 614 260603 103874 64133641
Bronchopulmonary aspergillosis 37.71 10.04 15 261202 19070 64218445
Multiple sclerosis relapse 37.68 10.04 68 261149 41067 64196448
Orthostatic intolerance 37.48 10.04 39 261178 1561 64235954
Bronchitis 37.38 10.04 272 260945 108471 64129044
Bone marrow failure 37.37 10.04 87 261130 47865 64189650
N-terminal prohormone brain natriuretic peptide increased 37.17 10.04 58 261159 3501 64234014
Pregnancy 37.16 10.04 19 261198 20846 64216669
Skin weeping 37.13 10.04 26 261191 598 64236917
Dystonia 36.99 10.04 15 261202 18850 64218665
Feeling abnormal 36.96 10.04 354 260863 133248 64104267
Haemodialysis complication 36.93 10.04 20 261197 285 64237230
Graft versus host disease 36.55 10.04 6 261211 13807 64223708
Intentional product use issue 36.54 10.04 231 260986 95133 64142382
Orthopnoea 36.45 10.04 100 261117 9034 64228481
Low density lipoprotein abnormal 36.38 10.04 20 261197 294 64237221
Gingival hypertrophy 36.27 10.04 50 261167 2697 64234818
Injection site bruising 36.20 10.04 57 261160 36316 64201199
Congenital hiatus hernia 35.92 10.04 22 261195 400 64237115
Carotid artery stenosis 35.82 10.04 91 261126 7850 64229665
Erysipelas 35.82 10.04 99 261118 8982 64228533
Tricuspid valve incompetence 35.66 10.04 150 261067 16853 64220662
Blood potassium increased 35.64 10.04 203 261014 25777 64211738
Herpes zoster 35.64 10.04 182 261035 79005 64158510
C-reactive protein abnormal 35.59 10.04 39 261178 29008 64208507
Cytokine release syndrome 35.58 10.04 20 261197 20809 64216706
Chills 35.35 10.04 370 260847 136894 64100621
Accidental exposure to product 35.04 10.04 33 261184 26331 64211184
Ventricular hypokinesia 35.01 10.04 89 261128 7680 64229835
Nasal congestion 34.92 10.04 124 261093 59534 64177981
Fluid retention 34.82 10.04 124 261093 59482 64178033
Anxiety 34.78 10.04 594 260623 202055 64035460
Euglycaemic diabetic ketoacidosis 34.39 10.04 71 261146 5339 64232176
Rhinorrhoea 34.21 10.04 126 261091 59843 64177672
Arteriosclerosis coronary artery 34.14 10.04 139 261078 15390 64222125
Loss of personal independence in daily activities 34.05 10.04 164 261053 72290 64165225
Full blood count decreased 34.04 10.04 25 261192 22557 64214958
Liver disorder 33.90 10.04 107 261110 53244 64184271
Cerebral ischaemia 33.89 10.04 103 261114 9859 64227656
Hyperglycaemia 33.86 10.04 387 260830 60581 64176934
Fungal infection 33.78 10.04 54 261163 34197 64203318
Labile hypertension 33.54 10.04 23 261194 511 64237004
Diabetic ketoacidosis 33.25 10.04 221 260996 29624 64207891
Folliculitis 33.02 10.04 44 261173 30033 64207482
Hypokalaemia 32.77 10.04 684 260533 121219 64116296
Hypomagnesaemia 32.58 10.04 261 260956 37115 64200400
Therapeutic response unexpected 32.56 10.04 14 261203 16987 64220528
Duodenal ulcer 32.36 10.04 130 261087 14305 64223210
Duodenitis 32.25 10.04 79 261138 6662 64230853
Thirst 32.24 10.04 128 261089 14009 64223506
Hypovolaemic shock 32.02 10.04 103 261114 10163 64227352
Muscle injury 31.84 10.04 36 261181 26401 64211114
Systolic dysfunction 31.81 10.04 51 261166 3151 64234364
Transient ischaemic attack 31.45 10.04 295 260922 43887 64193628
Metabolic acidosis 31.11 10.04 431 260786 70527 64166988
Acute respiratory distress syndrome 30.85 10.04 70 261147 38865 64198650
Cardiogenic shock 30.80 10.04 231 260986 32196 64205319
Occult blood 30.76 10.04 33 261184 1369 64236146
Cold sweat 30.58 10.04 140 261077 16315 64221200
Abnormal loss of weight 30.51 10.04 82 261135 7318 64230197
Adverse drug reaction 30.44 10.04 89 261128 45375 64192140
Cytomegalovirus viraemia 30.28 10.04 4 261213 10824 64226691
Mouth swelling 30.12 10.04 65 261152 5042 64232473
Fracture 30.11 10.04 153 261064 18602 64218913
Arterial occlusive disease 30.08 10.04 79 261138 6954 64230561
Malaise 29.66 10.04 1922 259295 394325 63843190
Encephalopathy 29.50 10.04 130 261087 58689 64178826
Hypoglycaemic coma 29.45 10.04 58 261159 4216 64233299
Myositis 29.44 10.04 138 261079 16239 64221276
Sepsis 29.41 10.04 709 260508 229632 64007883
Weight increased 29.40 10.04 649 260568 212699 64024816
Pain in jaw 29.36 10.04 77 261140 40678 64196837
Cardiac aneurysm 29.25 10.04 31 261186 1268 64236247
Dermatitis allergic 29.16 10.04 130 261087 14979 64222536
Disorientation 29.06 10.04 350 260867 55478 64182037
Device difficult to use 28.94 10.04 3 261214 9795 64227720
Adverse event 28.91 10.04 74 261143 39415 64198100
Actinic elastosis 28.82 10.04 10 261207 42 64237473
Lethargy 28.68 10.04 433 260784 72161 64165354
Epiglottic oedema 28.42 10.04 16 261201 247 64237268
Hypersomnia 28.23 10.04 23 261194 19694 64217821
Unevaluable event 28.20 10.04 107 261110 50382 64187133
Myelosuppression 28.10 10.04 33 261184 23797 64213718
Eosinophilic bronchitis 28.02 10.04 18 261199 357 64237158
Pulmonary vascular disorder 28.02 10.04 26 261191 903 64236612
Oral herpes 27.97 10.04 29 261188 22123 64215392
Pulmonary arterial hypertension 27.96 10.04 37 261180 25330 64212185
Inappropriate antidiuretic hormone secretion 27.89 10.04 170 261047 22119 64215396
Mucosal haemorrhage 27.86 10.04 40 261177 2241 64235274
Vomiting 27.84 10.04 2592 258625 548525 63688990
Epstein-Barr virus infection 27.83 10.04 8 261209 12480 64225035
Pneumocystis jirovecii pneumonia 27.79 10.04 43 261174 27591 64209924
Insomnia 27.78 10.04 600 260617 197236 64040279
Rheumatoid factor positive 27.53 10.04 63 261154 34875 64202640
Myopathy 27.53 10.04 143 261074 17537 64219978
Pharyngeal oedema 27.29 10.04 130 261087 15401 64222114
Arteriosclerosis 27.25 10.04 132 261085 15745 64221770
Impaired healing 27.20 10.04 139 261078 60334 64177181
Liver injury 27.18 10.04 211 261006 29721 64207794
Sedation 27.16 10.04 82 261135 41380 64196135
Dermatitis exfoliative 27.14 10.04 98 261119 10254 64227261
Injection site rash 27.05 10.04 15 261202 15727 64221788
Brain stem infarction 26.85 10.04 35 261182 1788 64235727
Therapeutic response decreased 26.39 10.04 115 261102 52073 64185442
No adverse event 26.35 10.04 47 261170 28514 64209001
Seizure 26.16 10.04 497 260720 166395 64071120
Oropharyngeal swelling 26.07 10.04 28 261189 1163 64236352
Multiple sclerosis 26.01 10.04 23 261194 18918 64218597
Enthesopathy 25.92 10.04 4 261213 9634 64227881
Brain stem stroke 25.90 10.04 18 261199 409 64237106
Intraventricular haemorrhage 25.81 10.04 54 261163 4099 64233416
Left ventricular hypertrophy 25.79 10.04 91 261126 9415 64228100
Disseminated intravascular coagulation 25.76 10.04 58 261159 32290 64205225
Mydriasis 25.73 10.04 15 261202 15297 64222218
Haematotoxicity 25.70 10.04 10 261207 12886 64224629
Mouth breathing 25.61 10.04 12 261205 123 64237392
Thrombosis 25.60 10.04 174 261043 70468 64167047
Laryngeal oedema 25.58 10.04 75 261142 7038 64230477
Urosepsis 25.46 10.04 165 261052 21929 64215586
Cough 25.27 10.04 1480 259737 300668 63936847
Lichenoid keratosis 25.13 10.04 47 261170 3287 64234228
Jealous delusion 25.04 10.04 14 261203 213 64237302
Hepatitis acute 24.94 10.04 114 261103 13275 64224240
Bone erosion 24.80 10.04 8 261209 11587 64225928
Electrocardiogram QT prolonged 24.80 10.04 456 260761 78992 64158523
Posterior reversible encephalopathy syndrome 24.75 10.04 34 261183 22912 64214603
Carotid arteriosclerosis 24.73 10.04 36 261181 2043 64235472
Pathogen resistance 24.55 10.04 10 261207 12533 64224982
Infective exacerbation of chronic obstructive airways disease 24.45 10.04 39 261178 2399 64235116
Sedation complication 24.27 10.04 6 261211 10348 64227167
Hepatic enzyme increased 24.23 10.04 375 260842 129568 64107947
Hypogammaglobulinaemia 24.08 10.04 6 261211 10293 64227222
Neoplasm progression 24.07 10.04 85 261132 40879 64196636
Hypersensitivity vasculitis 24.03 10.04 71 261146 6690 64230825
Dyspnoea exertional 24.00 10.04 426 260791 73304 64164211
Tenosynovitis 23.88 10.04 9 261208 11824 64225691
Gastroenteritis clostridial 23.81 10.04 22 261195 760 64236755
Nephrotic syndrome 23.76 10.04 89 261128 9478 64228037
Blood pressure systolic decreased 23.55 10.04 84 261133 8736 64228779
Bundle branch block right 23.44 10.04 93 261124 10176 64227339
Underdose 23.39 10.04 43 261174 25786 64211729
Ventricular tachyarrhythmia 23.38 10.04 14 261203 244 64237271
Cerebral artery thrombosis 23.36 10.04 25 261192 1034 64236481
Hot flush 23.30 10.04 102 261115 46133 64191382
Aspartate aminotransferase increased 23.26 10.04 343 260874 119445 64118070
Ocular myasthenia 23.16 10.04 16 261201 360 64237155
Change of bowel habit 23.09 10.04 38 261179 2400 64235115
Acute pulmonary oedema 23.08 10.04 108 261109 12701 64224814
Nocturia 23.02 10.04 98 261119 11067 64226448
Epistaxis 23.01 10.04 540 260677 97591 64139924
Normocytic anaemia 23.01 10.04 45 261172 3254 64234261
Ear infection 22.99 10.04 37 261180 23367 64214148
Gastrointestinal haemorrhage 22.96 10.04 700 260517 131612 64105903
Immune reconstitution inflammatory syndrome 22.74 10.04 11 261206 12459 64225056
Pulmonary mass 22.63 10.04 39 261178 23977 64213538
Benign prostatic hyperplasia 22.55 10.04 85 261132 9080 64228435
Hemiplegia 22.52 10.04 107 261110 12661 64224854
Hypoalbuminaemia 22.47 10.04 23 261194 17651 64219864
Coma scale abnormal 22.46 10.04 76 261141 7698 64229817
Musculoskeletal pain 22.45 10.04 458 260759 80836 64156679
Hypertrophy 22.40 10.04 21 261196 739 64236776
Haemophagocytic lymphohistiocytosis 22.29 10.04 23 261194 17586 64219929
Oxygen saturation decreased 22.18 10.04 303 260914 106873 64130642
Depressed mood 22.18 10.04 259 260958 40753 64196762
Cardiac septal hypertrophy 22.09 10.04 13 261204 219 64237296
Abdominal pain lower 22.08 10.04 183 261034 26286 64211229
Clostridium difficile infection 21.95 10.04 74 261143 36089 64201426
Rheumatoid nodule 21.82 10.04 12 261205 12639 64224876
Troponin I increased 21.81 10.04 48 261169 3773 64233742
Helicobacter test positive 21.71 10.04 24 261193 1030 64236485
Upper motor neurone lesion 21.64 10.04 13 261204 228 64237287
Helicobacter infection 21.62 10.04 81 261136 38281 64199234
Ketoacidosis 21.54 10.04 69 261148 6794 64230721
Heavy menstrual bleeding 21.50 10.04 11 261206 12066 64225449
Brain scan abnormal 21.35 10.04 25 261192 1143 64236372
Pharyngeal swelling 21.33 10.04 60 261157 5499 64232016
Renal artery stenosis 21.32 10.04 41 261176 2928 64234587
Eosinophilia 21.28 10.04 242 260975 37834 64199681
Melanoderma 21.27 10.04 15 261202 349 64237166
Myocardial ischaemia 21.16 10.04 164 261053 23087 64214428
Cellulitis 21.14 10.04 260 260957 93397 64144118
Arthritis 21.13 10.04 227 260990 83587 64153928
Product storage error 21.06 10.04 14 261203 13304 64224211
Abnormal clotting factor 21.05 10.04 10 261207 106 64237409
Granulocytopenia 20.97 10.04 8 261209 10432 64227083
Macrophages increased 20.88 10.04 12 261205 193 64237322
Nephroangiosclerosis 20.81 10.04 14 261203 301 64237214
Basal ganglia haemorrhage 20.72 10.04 27 261190 1379 64236136
Blood sodium decreased 20.56 10.04 196 261021 29286 64208229
Vaginal haemorrhage 20.53 10.04 29 261188 19315 64218200
Ventricular enlargement 20.52 10.04 17 261200 506 64237009
Carcinogenicity 20.52 10.04 9 261208 78 64237437
Appendicitis 20.48 10.04 15 261202 13554 64223961
Acne 20.39 10.04 39 261178 23042 64214473
Lymphocyte count decreased 20.38 10.04 90 261127 40609 64196906
Pharyngitis streptococcal 20.36 10.04 5 261212 8663 64228852
Therapy partial responder 20.34 10.04 8 261209 10240 64227275
Abnormal weight gain 20.30 10.04 34 261183 2179 64235336
Pancytopenia 20.29 10.04 434 260783 142875 64094640
Band neutrophil percentage decreased 20.22 10.04 6 261211 13 64237502
Injection site urticaria 20.18 10.04 10 261207 11171 64226344
Xyphoid retraction 19.99 10.04 11 261206 162 64237353
Faeces discoloured 19.94 10.04 175 261042 25554 64211961
Respiratory tract inflammation 19.86 10.04 20 261197 770 64236745
Injection site haemorrhage 19.77 10.04 43 261174 24235 64213280
Faecaloma 19.76 10.04 85 261132 9643 64227872
Neuroleptic malignant syndrome 19.76 10.04 45 261172 24951 64212564
Gastritis haemorrhagic 19.75 10.04 34 261183 2228 64235287
Antidepressant drug level above therapeutic 19.72 10.04 17 261200 535 64236980
Electrocardiogram Q wave abnormal 19.68 10.04 15 261202 395 64237120
Left atrial dilatation 19.62 10.04 38 261179 2728 64234787
Pulmonary thrombosis 19.61 10.04 9 261208 10509 64227006
Respiratory tract haemorrhage 19.58 10.04 27 261190 1457 64236058
Listless 19.55 10.04 42 261175 3248 64234267
Arterial stenosis 19.49 10.04 26 261191 1359 64236156
Illness 19.44 10.04 37 261180 21901 64215614
Hallucination 19.42 10.04 408 260809 72380 64165135
Nicotine dependence 19.35 10.04 20 261197 794 64236721
Hypercreatininaemia 19.33 10.04 20 261197 795 64236720
Subdural haematoma 19.31 10.04 186 261031 27868 64209647
Immune-mediated myositis 19.25 10.04 37 261180 2641 64234874
Dilatation ventricular 19.20 10.04 46 261171 3824 64233691
Ischaemia 19.17 10.04 69 261148 7209 64230306
ECG signs of myocardial ischaemia 19.16 10.04 14 261203 345 64237170
Peripheral swelling 19.08 10.04 674 260543 208479 64029036
Faeces pale 19.07 10.04 36 261181 2535 64234980
Muscle enzyme increased 19.02 10.04 14 261203 349 64237166
Ischaemic cardiomyopathy 19.01 10.04 66 261151 6772 64230743
Type V hyperlipidaemia 19.00 10.04 21 261196 901 64236614
Device leakage 18.97 10.04 5 261212 8261 64229254
Analgesic drug level above therapeutic 18.92 10.04 15 261202 419 64237096
Patent ductus arteriosus 18.90 10.04 9 261208 96 64237419
Discomfort 18.84 10.04 223 260994 80655 64156860
Reduced facial expression 18.76 10.04 32 261185 2081 64235434
Hypertensive angiopathy 18.73 10.04 9 261208 98 64237417
Hospice care 18.71 10.04 4 261213 7621 64229894
Pulmonary alveolar haemorrhage 18.68 10.04 8 261209 9730 64227785
Full blood count abnormal 18.68 10.04 60 261157 29697 64207818
Pneumonia bacterial 18.63 10.04 20 261197 15015 64222500
Premature delivery 18.62 10.04 29 261188 18560 64218955
Pulmonary fibrosis 18.59 10.04 194 261023 29684 64207831
Gravitational oedema 18.52 10.04 28 261189 1644 64235871
Fibromyalgia 18.51 10.04 78 261139 35653 64201862
Left ventricular enlargement 18.46 10.04 18 261199 666 64236849
Hypercholesterolaemia 18.45 10.04 116 261101 15257 64222258
Eczema nummular 18.42 10.04 13 261204 303 64237212
Genitourinary symptom 18.34 10.04 12 261205 246 64237269
Heart rate decreased 18.22 10.04 319 260898 54748 64182767
Infusion site erythema 18.15 10.04 3 261214 6870 64230645
Polyuria 18.14 10.04 100 261117 12543 64224972
Irregular sleep wake rhythm disorder 18.13 10.04 13 261204 311 64237204
Cardiac output decreased 18.12 10.04 28 261189 1676 64235839
Acute graft versus host disease in skin 18.09 10.04 3 261214 6852 64230663
Post procedural haematoma 18.08 10.04 33 261184 2265 64235250
Monoparesis 18.06 10.04 38 261179 2896 64234619
Eczema 18.03 10.04 192 261025 29528 64207987
Femur fracture 18.01 10.04 74 261143 34061 64203454
Nephritic syndrome 18.00 10.04 12 261205 254 64237261
Low cardiac output syndrome 17.95 10.04 19 261198 776 64236739
Psychogenic tremor 17.93 10.04 6 261211 22 64237493
Fluid intake reduced 17.91 10.04 54 261163 5146 64232369
Arteriosclerotic gangrene 17.88 10.04 8 261209 73 64237442
Deep vein thrombosis 17.80 10.04 309 260908 104873 64132642
Hyperammonaemia 17.66 10.04 9 261208 9895 64227620
Inappropriate schedule of product administration 17.65 10.04 265 260952 92021 64145494
Unintentional medical device removal 17.65 10.04 3 261214 6731 64230784
Cytopenia 17.63 10.04 22 261195 15449 64222066
Chromaturia 17.63 10.04 154 261063 22457 64215058
Poisoning 17.61 10.04 39 261178 21840 64215675
Oral neoplasm 17.60 10.04 8 261209 76 64237439
Gynaecomastia 17.55 10.04 59 261158 5957 64231558
Hyperthyroidism 17.54 10.04 130 261087 18049 64219466
Tachycardia 17.52 10.04 757 260460 148822 64088693
Shock 17.46 10.04 234 260983 38006 64199509
Septic shock 17.45 10.04 311 260906 105126 64132389
Oedema mouth 17.44 10.04 37 261180 2836 64234679
Adenovirus infection 17.41 10.04 4 261213 7251 64230264
Product quality issue 17.40 10.04 62 261155 29737 64207778
Skin turgor decreased 17.37 10.04 17 261200 632 64236883
Drop attacks 17.36 10.04 21 261196 994 64236521
Tooth dislocation 17.33 10.04 6 261211 25 64237490
Foot deformity 17.26 10.04 25 261192 16479 64221036
Hip arthroplasty 17.23 10.04 38 261179 21313 64216202
Mitral valve disease 17.22 10.04 35 261182 2603 64234912
Transfusion 17.16 10.04 29 261188 17965 64219550
Temperature intolerance 17.13 10.04 6 261211 8249 64229266
Electrocardiogram ambulatory abnormal 17.11 10.04 5 261212 10 64237505
Dry skin 17.08 10.04 129 261088 51032 64186483
Nodule 17.04 10.04 29 261188 17918 64219597
Blood glucose fluctuation 17.02 10.04 58 261159 5897 64231618
Frequent bowel movements 17.00 10.04 30 261187 18275 64219240
Post-traumatic amnestic disorder 17.00 10.04 7 261210 51 64237464
Cardioactive drug level increased 16.99 10.04 41 261176 3424 64234091
Ear pain 16.98 10.04 49 261168 25087 64212428
Aspergillus infection 16.94 10.04 25 261192 16354 64221161
Suspiciousness 16.79 10.04 16 261201 575 64236940
Gout 16.78 10.04 146 261071 21267 64216248
Coronary arterial stent insertion 16.76 10.04 56 261161 5636 64231879
Bradyphrenia 16.72 10.04 79 261138 9327 64228188
Device use error 16.71 10.04 3 261214 6468 64231047
Megakaryocytes increased 16.66 10.04 8 261209 87 64237428
Loss of proprioception 16.66 10.04 17 261200 665 64236850
Complication associated with device 16.61 10.04 22 261195 15058 64222457
Eye irritation 16.60 10.04 24 261193 15832 64221683
Injection site warmth 16.58 10.04 18 261199 13444 64224071
Helicobacter gastritis 16.56 10.04 31 261186 2169 64235346
Cerebral artery occlusion 16.47 10.04 26 261191 1585 64235930
Frontotemporal dementia 16.46 10.04 15 261202 509 64237006
Mitral valve hypoplasia 16.45 10.04 6 261211 30 64237485
Shone complex 16.45 10.04 6 261211 30 64237485
Hypoaesthesia 16.44 10.04 433 260784 138675 64098840
Intrapericardial thrombosis 16.44 10.04 7 261210 56 64237459
Ammonia increased 16.44 10.04 4 261213 6973 64230542
Gangrene 16.38 10.04 66 261151 7272 64230243
Osteomyelitis 16.37 10.04 57 261160 27530 64209985
Failure to thrive 16.37 10.04 11 261206 10393 64227122
Malnutrition 16.30 10.04 33 261184 19092 64218423
Troponin T increased 16.29 10.04 32 261185 2321 64235194
Congenital aortic valve stenosis 16.29 10.04 6 261211 31 64237484
Constipation 16.22 10.04 761 260456 228576 64008939
Blood pressure systolic increased 16.19 10.04 286 260931 49167 64188348
Lividity 16.16 10.04 13 261204 371 64237144
Sudden cardiac death 16.14 10.04 48 261169 4539 64232976
Cystitis haemorrhagic 16.14 10.04 6 261211 7950 64229565
Aorta hypoplasia 16.13 10.04 6 261211 32 64237483
Thyroiditis acute 16.13 10.04 10 261207 186 64237329
Tongue biting 16.09 10.04 27 261190 1733 64235782
Injection site discolouration 16.08 10.04 4 261213 6871 64230644
Coronary artery bypass 16.06 10.04 56 261161 5759 64231756
BK virus infection 16.06 10.04 5 261212 7407 64230108
Ascites 16.00 10.04 167 261050 61834 64175681
Perineal pain 15.94 10.04 20 261197 983 64236532
Abdominal pain upper 15.90 10.04 864 260353 174166 64063349
Staphylococcal infection 15.89 10.04 130 261087 50548 64186967
Ventricular dysfunction 15.65 10.04 52 261165 5218 64232297
Camptocormia 15.56 10.04 14 261203 467 64237048
Cardiomyopathy 15.47 10.04 164 261053 25192 64212323
Laboratory test abnormal 15.47 10.04 48 261169 24015 64213500
Lymphadenopathy 15.45 10.04 118 261099 46568 64190947
Ankylosing spondylitis 15.42 10.04 7 261210 8227 64229288
Hepatitis cholestatic 15.39 10.04 93 261124 12062 64225453
Troponin increased 15.36 10.04 111 261106 15288 64222227
Pneumothorax 15.24 10.04 49 261168 24249 64213266
Arterial spasm 15.22 10.04 9 261208 153 64237362
Red blood cell count decreased 15.22 10.04 124 261093 48262 64189253
Intestinal haemorrhage 15.14 10.04 53 261164 5461 64232054
Petechiae 15.12 10.04 128 261089 18498 64219017
Tongue disorder 15.04 10.04 16 261201 12064 64225451
Congenital heart valve disorder 15.02 10.04 6 261211 40 64237475
Hepatorenal failure 14.98 10.04 21 261196 1151 64236364
Atrial thrombosis 14.92 10.04 36 261181 3006 64234509
Rhinitis allergic 14.92 10.04 7 261210 8071 64229444
Multiple drug therapy 14.82 10.04 30 261187 2224 64235291
Oesophagitis haemorrhagic 14.82 10.04 15 261202 581 64236934
Dyspnoea paroxysmal nocturnal 14.79 10.04 28 261189 1976 64235539
Vulval cancer 14.77 10.04 13 261204 421 64237094
Rales 14.75 10.04 109 261108 15120 64222395
Protein urine present 14.73 10.04 9 261208 8947 64228568
Akinesia 14.64 10.04 36 261181 3043 64234472
Drug eruption 14.63 10.04 86 261131 36050 64201465
Brain stem ischaemia 14.63 10.04 10 261207 221 64237294
Prerenal failure 14.61 10.04 37 261180 3185 64234330
Incorrect route of product administration 14.61 10.04 47 261170 23251 64214264
Brain compression 14.60 10.04 14 261203 507 64237008
Irritability 14.59 10.04 88 261129 36658 64200857
Knee arthroplasty 14.57 10.04 58 261159 26941 64210574
Parkinsonism 14.57 10.04 104 261113 14269 64223246
Urticaria 14.54 10.04 470 260747 146847 64090668
Acute abdomen 14.48 10.04 34 261183 2790 64234725
Fracture blisters 14.35 10.04 7 261210 79 64237436
Hypoaesthesia eye 14.35 10.04 7 261210 79 64237436
Spinal cord haemorrhage 14.29 10.04 14 261203 521 64236994
Chronic kidney disease 14.28 10.04 321 260896 57598 64179917
Muscle discomfort 14.24 10.04 8 261209 123 64237392
Coronary artery dissection 14.23 10.04 18 261199 892 64236623
Disability 14.20 10.04 17 261200 12155 64225360
Stenosis 14.20 10.04 26 261191 1789 64235726
Gastric ulcer haemorrhage 14.19 10.04 68 261149 8075 64229440
Accessory spleen 14.12 10.04 9 261208 176 64237339
Pelvic pain 14.10 10.04 14 261203 10896 64226619
Seasonal allergy 14.09 10.04 16 261201 11710 64225805
Strangury 14.03 10.04 9 261208 178 64237337
Tendon rupture 14.03 10.04 83 261134 10684 64226831
Ocular icterus 14.00 10.04 49 261168 5049 64232466
Neoplasm malignant 13.99 10.04 52 261165 24636 64212879
Incorrect dose administered 13.97 10.04 168 261049 60597 64176918
Shock hypoglycaemic 13.91 10.04 10 261207 240 64237275
Precancerous skin lesion 13.90 10.04 20 261197 1123 64236392
Pseudocyst 13.88 10.04 11 261206 307 64237208
Febrile infection 13.88 10.04 34 261183 2867 64234648
Back disorder 13.88 10.04 12 261205 9978 64227537
Upper gastrointestinal haemorrhage 13.87 10.04 210 261007 35010 64202505
Amyloidosis 13.87 10.04 31 261186 2463 64235052
Hypercapnic coma 13.86 10.04 12 261205 380 64237135
N-terminal prohormone brain natriuretic peptide abnormal 13.77 10.04 10 261207 244 64237271
Anal haemorrhage 13.76 10.04 37 261180 3303 64234212
Left ventricular failure 13.75 10.04 69 261148 8348 64229167
Restlessness 13.71 10.04 232 260985 39553 64197962
Supravalvular aortic stenosis 13.71 10.04 5 261212 25 64237490
Congenital aortic stenosis 13.71 10.04 5 261212 25 64237490
Congenital aortic anomaly 13.71 10.04 5 261212 25 64237490
Vasculitic rash 13.69 10.04 27 261190 1964 64235551
Sex hormone binding globulin increased 13.69 10.04 4 261213 8 64237507
Breast cancer 13.68 10.04 66 261151 29082 64208433
Adrenal insufficiency 13.66 10.04 46 261171 22441 64215074
Sinus arrhythmia 13.64 10.04 26 261191 1844 64235671
Mitral valve thickening 13.62 10.04 12 261205 389 64237126
Chronotropic incompetence 13.62 10.04 7 261210 89 64237426
Joint stiffness 13.61 10.04 70 261147 30334 64207181
Viral diarrhoea 13.60 10.04 10 261207 249 64237266
Hypercreatinaemia 13.60 10.04 10 261207 249 64237266
Sinoatrial block 13.59 10.04 20 261197 1146 64236369
Urinary hesitation 13.58 10.04 38 261179 3472 64234043
Obstructive pancreatitis 13.49 10.04 15 261202 648 64236867
Brain natriuretic peptide increased 13.49 10.04 64 261153 7569 64229946
Visual field defect 13.46 10.04 67 261150 8079 64229436
Night sweats 13.45 10.04 88 261129 35958 64201557
Cushingoid 13.42 10.04 7 261210 7596 64229919
Product administration error 13.39 10.04 171 261046 27472 64210043
Fibrinolysis increased 13.39 10.04 5 261212 27 64237488
Hypothermia 13.35 10.04 131 261086 19725 64217790
Prostatic haemorrhage 13.28 10.04 8 261209 141 64237374
Diastolic dysfunction 13.28 10.04 71 261146 8804 64228711
Hemianopia 13.26 10.04 23 261194 1516 64235999
Nitritoid reaction 13.24 10.04 5 261212 28 64237487
Facial bones fracture 13.21 10.04 43 261174 4269 64233246
Urinary retention 13.19 10.04 276 260941 48925 64188590
Contraindicated product administered 13.17 10.04 334 260883 107495 64130020
Throat irritation 13.17 10.04 78 261139 32633 64204882
Haemorrhagic stroke 13.16 10.04 77 261140 9874 64227641
Embolic stroke 13.14 10.04 58 261159 6653 64230862
Resuscitation 13.14 10.04 27 261190 2024 64235491
Endoscopy upper gastrointestinal tract 13.10 10.04 7 261210 97 64237418
Macrophage activation 13.08 10.04 4 261213 10 64237505
Speech disorder 13.07 10.04 272 260945 48169 64189346
Hypochloraemia 13.04 10.04 27 261190 2034 64235481
Vasodilatation 13.01 10.04 34 261183 2984 64234531
Depression 13.00 10.04 608 260609 182683 64054832
Colitis erosive 12.97 10.04 7 261210 99 64237416
Coarctation of the aorta 12.93 10.04 6 261211 60 64237455
Vascular access site occlusion 12.93 10.04 6 261211 60 64237455
Impaired quality of life 12.93 10.04 5 261212 6466 64231049
Heat stroke 12.87 10.04 22 261195 1433 64236082
Toxic neuropathy 12.86 10.04 16 261201 780 64236735
Blood product transfusion dependent 12.85 10.04 11 261206 343 64237172
Foetal death 12.85 10.04 4 261213 5926 64231589
Endoscopy upper gastrointestinal tract abnormal 12.81 10.04 4 261213 11 64237504
Device breakage 12.80 10.04 10 261207 8745 64228770
Urinary tract infection 12.73 10.04 788 260429 230808 64006707
Anaemia macrocytic 12.71 10.04 43 261174 4355 64233160
International normalised ratio decreased 12.71 10.04 62 261155 7416 64230099
Nodal arrhythmia 12.68 10.04 25 261192 1818 64235697
Pneumonia viral 12.67 10.04 8 261209 7814 64229701
Supine hypertension 12.66 10.04 11 261206 350 64237165
Peripheral arterial occlusive disease 12.65 10.04 59 261158 6928 64230587
Bronchomalacia 12.63 10.04 9 261208 213 64237302
Oral dysaesthesia 12.62 10.04 8 261209 155 64237360
Sinus node dysfunction 12.62 10.04 58 261159 6770 64230745
Hiatus hernia 12.61 10.04 130 261087 19827 64217688
Gastrooesophageal reflux disease 12.59 10.04 249 260968 82894 64154621
Tooth injury 12.58 10.04 21 261196 1342 64236173
Immobile 12.56 10.04 53 261164 5962 64231553
Sleep disorder due to a general medical condition 12.56 10.04 9 261208 8225 64229290
Mean cell haemoglobin concentration 12.56 10.04 5 261212 33 64237482
Subclavian artery occlusion 12.53 10.04 8 261209 157 64237358
Sinus arrest 12.50 10.04 34 261183 3056 64234459
Normochromic normocytic anaemia 12.49 10.04 57 261160 6633 64230882
Akathisia 12.47 10.04 17 261200 11493 64226022
Multiple allergies 12.46 10.04 4 261213 5810 64231705
Base excess decreased 12.45 10.04 11 261206 358 64237157
Glomerular filtration rate abnormal 12.43 10.04 20 261197 1239 64236276
Acute myeloid leukaemia 12.42 10.04 63 261154 27400 64210115
Apathy 12.41 10.04 83 261134 11149 64226366
Peritonitis bacterial 12.39 10.04 11 261206 9032 64228483
Respiratory syncytial virus infection 12.38 10.04 7 261210 7261 64230254
Thrombocytopenia 12.38 10.04 761 260456 223040 64014475
Genital infection female 12.36 10.04 6 261211 67 64237448
Hip fracture 12.35 10.04 62 261155 27037 64210478
Gastrointestinal angiodysplasia 12.35 10.04 17 261200 916 64236599
Chronic cutaneous lupus erythematosus 12.35 10.04 9 261208 221 64237294
Withdrawal syndrome 12.35 10.04 51 261166 23441 64214074
Tumour lysis syndrome 12.34 10.04 39 261178 19401 64218114
Bladder neoplasm 12.32 10.04 22 261195 1484 64236031
Pneumatosis intestinalis 12.32 10.04 3 261214 5226 64232289
Pulmonary tuberculosis 12.31 10.04 7 261210 7237 64230278
Red blood cell sedimentation rate increased 12.30 10.04 75 261142 31160 64206355
Oliguria 12.28 10.04 101 261116 14475 64223040
Delusion 12.25 10.04 35 261182 17979 64219536
Gastroenteritis eosinophilic 12.21 10.04 9 261208 225 64237290
Angiopathy 12.16 10.04 54 261163 6211 64231304
Blood pressure decreased 12.13 10.04 445 260772 85754 64151761
Injection site extravasation 12.12 10.04 9 261208 8077 64229438
Micturition disorder 12.10 10.04 34 261183 3114 64234401
Chest wall haematoma 12.10 10.04 11 261206 372 64237143
Osteonecrosis 12.07 10.04 66 261151 28163 64209352
Dysgeusia 12.03 10.04 127 261090 46920 64190595
Grip strength decreased 12.02 10.04 18 261199 11706 64225809
Neck pain 12.00 10.04 176 261041 61357 64176158
Herpes simplex 11.99 10.04 15 261202 10521 64226994
Nightmare 11.99 10.04 134 261083 20859 64216656
Genital herpes simplex 11.98 10.04 10 261207 301 64237214
Joint injury 11.94 10.04 50 261167 22897 64214618
Panniculitis 11.93 10.04 11 261206 8868 64228647
Bleeding time prolonged 11.93 10.04 19 261198 1167 64236348
Oxygen consumption decreased 11.93 10.04 11 261206 379 64237136
Cholecystitis chronic 11.90 10.04 12 261205 9275 64228240
Asthma 11.89 10.04 294 260923 94931 64142584
Lymphoproliferative disorder 11.88 10.04 3 261214 5100 64232415
Contusion 11.87 10.04 361 260856 113604 64123911
Disturbance in attention 11.87 10.04 233 260984 40841 64196674
Body height decreased 11.86 10.04 8 261209 7546 64229969
Arterial intramural haematoma 11.84 10.04 6 261211 74 64237441
Polyp 11.83 10.04 56 261161 6617 64230898
Spinal operation 11.82 10.04 5 261212 6128 64231387
Hyperparathyroidism primary 11.79 10.04 11 261206 385 64237130
Cerebellar haemorrhage 11.67 10.04 30 261187 2607 64234908
Hypervolaemia 11.64 10.04 99 261118 38186 64199329
Interstitial lung disease 11.60 10.04 304 260913 97428 64140087
Peripartum cardiomyopathy 11.59 10.04 7 261210 124 64237391
Aortic valve sclerosis 11.58 10.04 22 261195 1557 64235958
Blood lactic acid increased 11.57 10.04 77 261140 10324 64227191
Bone pain 11.53 10.04 130 261087 47442 64190073
Haematocrit decreased 11.49 10.04 154 261063 54501 64183014
Lymphostasis 11.49 10.04 4 261213 17 64237498
Metastases to lymph nodes 11.48 10.04 11 261206 8706 64228809
Aortic valve incompetence 11.48 10.04 65 261152 8236 64229279
Pacemaker generated arrhythmia 11.47 10.04 3 261214 3 64237512
Food interaction 11.47 10.04 21 261196 1445 64236070
Physical examination abnormal 11.46 10.04 9 261208 248 64237267
Osmotic demyelination syndrome 11.41 10.04 19 261198 1212 64236303
Microcytic anaemia 11.40 10.04 43 261174 4595 64232920
Osteoarthritis 11.39 10.04 184 261033 63152 64174363
Hypovolaemia 11.32 10.04 104 261113 15382 64222133
Blood parathyroid hormone decreased 11.30 10.04 8 261209 7358 64230157
Vascular purpura 11.23 10.04 29 261188 2527 64234988
Type 2 diabetes mellitus 11.22 10.04 197 261020 33823 64203692
Purpura 11.21 10.04 113 261104 17133 64220382
Sensory level abnormal 11.21 10.04 7 261210 132 64237383
Gastrointestinal perforation 11.16 10.04 4 261213 5420 64232095
Venous pressure jugular decreased 11.11 10.04 6 261211 85 64237430
Toothache 11.10 10.04 35 261182 17424 64220091
Gastrointestinal mucosal necrosis 11.10 10.04 8 261209 193 64237322
Lymphoma 11.10 10.04 25 261192 13916 64223599
Ulcerative gastritis 11.05 10.04 6 261211 86 64237429
Gingival swelling 11.04 10.04 38 261179 3882 64233633
Rabbit syndrome 11.00 10.04 10 261207 338 64237177
Phimosis 11.00 10.04 11 261206 420 64237095
Apheresis related complication 10.97 10.04 4 261213 20 64237495
Alveolitis necrotising 10.97 10.04 4 261213 20 64237495
Intracardiac thrombus 10.96 10.04 37 261180 3744 64233771
Glycosylated haemoglobin increased 10.92 10.04 106 261111 15913 64221602
Drug monitoring procedure not performed 10.91 10.04 15 261202 807 64236708
Hepatic encephalopathy 10.90 10.04 46 261171 21020 64216495
Blood pressure inadequately controlled 10.90 10.04 47 261170 5337 64232178
Genital paraesthesia 10.87 10.04 5 261212 49 64237466
Mucosal inflammation 10.86 10.04 183 261034 62401 64175114
Rheumatoid arthritis 10.86 10.04 549 260668 163745 64073770
Paradoxical psoriasis 10.85 10.04 7 261210 140 64237375
Idiopathic angioedema 10.81 10.04 4 261213 21 64237494
Anal paraesthesia 10.81 10.04 4 261213 21 64237494
Skin irritation 10.80 10.04 69 261148 9125 64228390
SARS-CoV-2 test positive 10.79 10.04 6 261211 6280 64231235
Duodenogastric reflux 10.78 10.04 5 261212 50 64237465
Premature labour 10.77 10.04 9 261208 7611 64229904
Blood creatine phosphokinase MB increased 10.76 10.04 29 261188 2592 64234923
Central nervous system mass 10.75 10.04 6 261211 91 64237424
Pre-existing condition improved 10.70 10.04 3 261214 4759 64232756
Sinus disorder 10.67 10.04 34 261183 16874 64220641
Retinal vein thrombosis 10.67 10.04 13 261204 620 64236895
Necrotising retinitis 10.65 10.04 17 261200 1046 64236469
Tenderness 10.65 10.04 42 261175 19560 64217955
Gastrointestinal pain 10.64 10.04 9 261208 7565 64229950
Infusion site pain 10.63 10.04 16 261201 10381 64227134
Urine analysis abnormal 10.62 10.04 5 261212 5751 64231764
Nervousness 10.60 10.04 73 261144 29483 64208032
Hepatotoxicity 10.57 10.04 107 261110 39855 64197660
Emotional disorder 10.54 10.04 22 261195 12585 64224930
Cerebellar stroke 10.54 10.04 11 261206 442 64237073
Mesenteric artery thrombosis 10.53 10.04 12 261205 533 64236982
Sputum discoloured 10.52 10.04 37 261180 17819 64219696
Electrocardiogram QT shortened 10.52 10.04 8 261209 210 64237305
Implant site extravasation 10.49 10.04 14 261203 732 64236783
Bundle branch block 10.48 10.04 20 261197 1420 64236095
Granuloma 10.47 10.04 7 261210 6634 64230881
On and off phenomenon 10.47 10.04 28 261189 2491 64235024
Joint dislocation 10.46 10.04 19 261198 11446 64226069
Prostatic disorder 10.45 10.04 22 261195 1677 64235838
Foot fracture 10.45 10.04 38 261179 18119 64219396
Duodenal ulcer haemorrhage 10.44 10.04 52 261165 6273 64231242
Nephritis allergic 10.43 10.04 13 261204 635 64236880
Skin candida 10.42 10.04 22 261195 1681 64235834
Wall motion score index abnormal 10.41 10.04 6 261211 97 64237418
Wheelchair user 10.40 10.04 3 261214 4669 64232846
Brain oedema 10.35 10.04 50 261167 22025 64215490
Cardiac discomfort 10.35 10.04 17 261200 1072 64236443
Middle insomnia 10.32 10.04 23 261194 12854 64224661
Lip blister 10.31 10.04 26 261191 2233 64235282
Hypomania 10.29 10.04 5 261212 5649 64231866
Implant site inflammation 10.29 10.04 8 261209 217 64237298
Diabetic ketoacidotic hyperglycaemic coma 10.29 10.04 8 261209 217 64237298
Fasciotomy 10.27 10.04 3 261214 6 64237509
Blood ethanol increased 10.27 10.04 13 261204 645 64236870
Gastroenteritis viral 10.26 10.04 43 261174 19686 64217829
Metastases to liver 10.22 10.04 56 261161 23885 64213630
Prothrombin time shortened 10.21 10.04 30 261187 2819 64234696
Hypertensive emergency 10.18 10.04 26 261191 2250 64235265
Normal newborn 10.17 10.04 5 261212 5612 64231903
Sensitisation 10.17 10.04 22 261195 1709 64235806
Drug tolerance 10.17 10.04 6 261211 6079 64231436
Granuloma skin 10.13 10.04 6 261211 6068 64231447
Invasive breast carcinoma 10.12 10.04 11 261206 463 64237052
Candida infection 10.12 10.04 80 261137 31339 64206176
Leptospirosis 10.10 10.04 4 261213 26 64237489
Computerised tomogram head abnormal 10.10 10.04 6 261211 103 64237412
Supraventricular tachyarrhythmia 10.10 10.04 6 261211 103 64237412
Haemarthrosis 10.10 10.04 45 261172 5184 64232331
Squamous cell carcinoma 10.07 10.04 93 261124 13776 64223739
Stoma site haemorrhage 10.06 10.04 21 261196 1592 64235923
Cyst 10.04 10.04 21 261196 12006 64225509
Hysterectomy 10.04 10.04 4 261213 5081 64232434

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
ATC C09BB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX17 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000181 Angiotensin-converting Enzyme Inhibitors
FDA EPC N0000175562 Angiotensin Converting Enzyme Inhibitor
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:35457 ACE inhibitor
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:50664 matrix metalloproteinase inhibitors
CHEBI has role CHEBI:77307 cardioprotective agents
CHEBI has role CHEBI:77496 bradykinin receptor B2 agonists
CHEBI has role CHEBI:49103 drug metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Cerebrovascular accident indication 230690007
Left ventricular cardiac dysfunction indication 429589006
Myocardial Infarction Prevention indication
Atrial fibrillation off-label use 49436004 DOID:0060224
Diabetic renal disease off-label use 127013003
Acute scleroderma renal crisis off-label use 236503001
Diastolic heart failure off-label use 418304008 DOID:9775
Hypertension due to Scleroderma off-label use
Nondiabetic Proteinuric Nephropathy off-label use
Hyperkalemia contraindication 14140009
Acute vomiting contraindication 23971007
Dehydration contraindication 34095006
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Oliguria contraindication 83128009
Systemic sclerosis contraindication 89155008 DOID:418
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Hyposensitization to allergens contraindication 182678001
Disease of liver contraindication 235856003 DOID:409
Renal dialysis contraindication 265764009
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Severe diarrhea contraindication 409587002
Azotemia contraindication 445009001
Head and Neck Angioedema contraindication
Intestinal Angioedema contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.21 acidic
pKa2 5.77 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR Ki 8.34 WOMBAT-PK CHEMBL
Angiotensin-converting enzyme Enzyme IC50 6.60 CHEMBL

External reference:

IDSource
4019562 VUID
N0000147662 NUI
D00421 KEGG_DRUG
4019562 VANDF
C0072973 UMLSCUI
CHEBI:8774 CHEBI
CHEBI:77363 CHEBI
X92 PDB_CHEM_ID
CHEMBL1168 ChEMBL_ID
D017257 MESH_DESCRIPTOR_UI
DB00178 DRUGBANK_ID
5362129 PUBCHEM_CID
6339 IUPHAR_LIGAND_ID
C052549 MESH_SUPPLEMENTAL_RECORD_UI
6344 IUPHAR_LIGAND_ID
5561 INN_ID
87269-97-4 SECONDARY_CAS_RN
L35JN3I7SJ UNII
5464096 PUBCHEM_CID
DB14208 DRUGBANK_ID
1546377 RXNORM
130231 MMSL
5411 MMSL
d00728 MMSL
003585 NDDF
108564000 SNOMEDCT_US
386872004 SNOMEDCT_US
C0072970 UMLSCUI
CHEMBL1201365 ChEMBL_ID
5713 INN_ID
6N5U4QFC3G UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0106 CAPSULE 1.25 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0107 CAPSULE 2.50 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0108 CAPSULE 5 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0109 CAPSULE 10 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 10544-588 CAPSULE 10 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-152 CAPSULE 1.25 mg ORAL ANDA 28 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-153 CAPSULE 2.50 mg ORAL ANDA 28 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-154 CAPSULE 5 mg ORAL ANDA 28 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-155 CAPSULE 10 mg ORAL ANDA 28 sections
RAMIPRIL HUMAN PRESCRIPTION DRUG LABEL 1 17856-0108 CAPSULE 5 mg ORAL ANDA 25 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-821 CAPSULE 2.50 mg ORAL ANDA 20 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-822 CAPSULE 5 mg ORAL ANDA 20 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-823 CAPSULE 10 mg ORAL ANDA 20 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-271 CAPSULE 1.25 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-272 CAPSULE 2.50 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-273 CAPSULE 5 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-274 CAPSULE 10 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 33261-903 CAPSULE 5 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 33261-967 CAPSULE 10 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 45865-441 CAPSULE 10 mg ORAL ANDA 28 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 45865-443 CAPSULE 5 mg ORAL ANDA 27 sections
Ramipril Human Prescription Drug Label 1 50090-1118 CAPSULE 5 mg ORAL ANDA 27 sections
Ramipril Human Prescription Drug Label 1 50090-1120 CAPSULE 10 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-3059 CAPSULE 2.50 mg ORAL ANDA 23 sections
Ramipril Human Prescription Drug Label 1 50090-3873 CAPSULE 2.50 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-4597 CAPSULE 5 mg ORAL ANDA 23 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-4691 CAPSULE 10 mg ORAL ANDA 23 sections
Ramipril Human Prescription Drug Label 1 50090-5673 CAPSULE 5 mg ORAL ANDA 26 sections
Ramipril Human Prescription Drug Label 1 50090-5730 CAPSULE 10 mg ORAL ANDA 26 sections
Ramipril Human Prescription Drug Label 1 50090-5947 CAPSULE 2.50 mg ORAL ANDA 26 sections