ramipril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
angiotensin-converting enzyme inhibitors	2356	87333-19-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: HOE498 HOE-498 ramipril	A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat. Molecular weight: 416.52 Formula: C23H32N2O5 CLOGP: 1.54 LIPINSKI: 0 HAC: 7 HDO: 2 TPSA: 95.94 ALOGS: -4.03 ROTB: 10 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

HOE498
HOE-498
ramipril

A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.

Molecular weight: 416.52
Formula: C23H32N2O5
CLOGP: 1.54
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 95.94
ALOGS: -4.03
ROTB: 10

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
2.50	mg	O

ADMET properties:

Show entries

Search:

Property	Value	Reference
BA (Bioavailability)	28 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
EoM (Fraction excreted unchanged in urine)	1.50 %	Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.69 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
S (Water solubility)	0.09 mg/mL	Bocci G, Oprea TI, Benet LZ

Showing 1 to 5 of 5 entries

Previous1Next

Approvals:

Date	Agency	Company	Orphan
Jan. 28, 1991	FDA	KING PHARMS

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	833.09	10.20	2284	201959	261131	63023648
Hyperkalaemia	637.30	10.20	828	203415	53375	63231404
Hyponatraemia	630.88	10.20	1220	203023	110680	63174099
General physical health deterioration	576.03	10.20	1685	202558	199717	63085062
Liver injury	520.49	10.20	796	203447	59724	63225055
Product dose omission issue	357.68	10.20	153	204090	234160	63050619
Angioedema	338.76	10.20	577	203666	47388	63237391
Drug interaction	337.08	10.20	1545	202698	227586	63057193
Completed suicide	333.12	10.20	39	204204	145634	63139145
Drug ineffective	328.47	10.20	1998	202245	1042767	62242012

Showing 1 to 10 of 637 entries

Previous1 2 3 4 5…64Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	641.21	10.69	3038	165829	301950	34486114
Death	537.50	10.69	683	168184	397366	34390698
General physical health deterioration	441.87	10.69	1493	167374	126776	34661288
Angioedema	392.46	10.69	672	168195	36702	34751362
Hyperkalaemia	385.43	10.69	959	167908	68430	34719634
Drug ineffective	371.80	10.69	1062	167805	455689	34332375
Off label use	325.54	10.69	997	167870	418527	34369537
Syncope	297.57	10.69	1045	167822	90406	34697658
Hypertensive crisis	274.94	10.69	271	168596	8480	34779584
Bradycardia	247.16	10.69	864	168003	74554	34713510

Showing 1 to 10 of 599 entries

Previous1 2 3 4 5…60Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	1493.79	9.61	5116	323741	514288	78901243
Hyperkalaemia	984.33	9.61	1724	327133	112674	79302857
General physical health deterioration	957.28	9.61	2897	325960	272341	79143190
Angioedema	653.88	9.61	1146	327711	74889	79340642
Completed suicide	605.53	9.61	136	328721	245631	79169900
Drug ineffective	552.25	9.61	2442	326415	1078471	78337060
Hyponatraemia	543.14	9.61	1791	327066	176057	79239474
Syncope	533.67	9.61	1791	327066	177658	79237873
Bradycardia	527.13	9.61	1486	327371	134071	79281460
Death	519.12	9.61	967	327890	565547	78849984

Showing 1 to 10 of 938 entries

Previous1 2 3 4 5…94Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	C09AA05	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain
ATC	C09BA05	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics
ATC	C09BB05	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers
ATC	C09BB07	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers
ATC	C09BX03	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations
ATC	C09BX05	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations
ATC	C10BX04	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
ATC	C10BX06	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
ATC	C10BX17	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
ATC	C10BX18	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs

Showing 1 to 10 of 23 entries

Previous1 2 3Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Chronic heart failure	indication	48447003
Cerebrovascular accident	indication	230690007
Left ventricular cardiac dysfunction	indication	429589006
Myocardial Infarction Prevention	indication
Atrial fibrillation	off-label use	49436004	DOID:0060224
Diabetic renal disease	off-label use	127013003
Acute scleroderma renal crisis	off-label use	236503001
Diastolic heart failure	off-label use	418304008	DOID:9775
Hypertension due to Scleroderma	off-label use

Showing 1 to 10 of 33 entries

Previous1 2 3 4Next

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.21	acidic
pKa2	5.77	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Angiotensin-converting enzyme	Enzyme	P12821	ACE_HUMAN	INHIBITOR	Ki	8.34		WOMBAT-PK	CHEMBL
Angiotensin-converting enzyme	Enzyme		ACE_RABIT		IC50	6.60		CHEMBL

Showing 1 to 2 of 2 entries

Previous1Next

External reference:

Show entries

Search:

ID	Source
X92	PDB_CHEM_ID
003585	NDDF
108564000	SNOMEDCT_US
130231	MMSL
1546377	RXNORM
386872004	SNOMEDCT_US
4019562	VUID
4019562	VANDF
5362129	PUBCHEM_CID
5411	MMSL

Showing 1 to 10 of 31 entries

Previous1 2 3 4Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ramipril	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0106	CAPSULE	1.25 mg	ORAL	ANDA	26 sections
Ramipril	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0107	CAPSULE	2.50 mg	ORAL	ANDA	26 sections
Ramipril	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0108	CAPSULE	5 mg	ORAL	ANDA	26 sections
Ramipril	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0109	CAPSULE	10 mg	ORAL	ANDA	26 sections
Ramipril	HUMAN PRESCRIPTION DRUG LABEL	1	10544-588	CAPSULE	10 mg	ORAL	ANDA	27 sections
Ramipril	HUMAN PRESCRIPTION DRUG LABEL	1	16729-152	CAPSULE	1.25 mg	ORAL	ANDA	28 sections
Ramipril	HUMAN PRESCRIPTION DRUG LABEL	1	16729-153	CAPSULE	2.50 mg	ORAL	ANDA	28 sections
Ramipril	HUMAN PRESCRIPTION DRUG LABEL	1	16729-154	CAPSULE	5 mg	ORAL	ANDA	28 sections
Ramipril	HUMAN PRESCRIPTION DRUG LABEL	1	16729-155	CAPSULE	10 mg	ORAL	ANDA	28 sections
RAMIPRIL	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0108	CAPSULE	5 mg	ORAL	ANDA	25 sections

Showing 1 to 10 of 30 entries

Previous1 2 3Next