carvedilol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
vasodilators	522	72956-09-3

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: carvedilol carvedilol phosphate carvediol carvedilol hydrochloride carvedilol HCl BM 14,190

A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION. Molecular weight: 406.48 Formula: C24H26N2O4 CLOGP: 4.04 LIPINSKI: 0 HAC: 6 HDO: 3 TPSA: 75.74 ALOGS: -4.96 ROTB: 10 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
37.50	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.01 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.03 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	1.30 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	7.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	2.40 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Sept. 14, 1995	FDA	SMITHKLINE BEECHAM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure congestive	1070.07	10.10	1042	80846	90708	46513466
Myocardial infarction	320.10	10.10	596	81292	96932	46507242
Cardiac failure	271.60	10.10	496	81392	79452	46524722
Rheumatoid arthritis	215.91	10.10	76	81812	240139	46364035
Hypotension	198.90	10.10	871	81017	231718	46372456
Bradycardia	191.44	10.10	384	81504	65914	46538260
Drug ineffective	176.63	10.10	606	81282	677232	45926942
Acute myocardial infarction	144.11	10.10	225	81663	31699	46572475
Cardiomyopathy	130.70	10.10	151	81737	15922	46588252
Hyperkalaemia	114.54	10.10	266	81622	50443	46553731
Acute kidney injury	111.20	10.10	751	81137	235104	46369070
Ejection fraction decreased	106.57	10.10	144	81744	17793	46586381
Gastrointestinal haemorrhage	100.06	10.10	331	81557	77042	46527132
Treatment failure	97.30	10.10	22	81866	93065	46511109
Chronic kidney disease	96.27	10.10	218	81670	40653	46563521
Coronary artery disease	93.21	10.10	192	81696	33560	46570614
Atrial fibrillation	89.08	10.10	389	81499	103201	46500973
Renal failure	79.67	10.10	402	81486	113192	46490982
Dyspnoea	77.49	10.10	1301	80587	514247	46089927
Cardiac disorder	71.98	10.10	204	81684	43654	46560520
Joint swelling	71.48	10.10	113	81775	165960	46438214
Maternal exposure during pregnancy	71.26	10.10	46	81842	102503	46501671
International normalised ratio increased	71.11	10.10	212	81676	46671	46557503
Syncope	69.38	10.10	365	81523	104438	46499736
Infusion related reaction	66.84	10.10	48	81840	101160	46503014
Synovitis	66.76	10.10	13	81875	61062	46543112
Contraindicated product administered	65.60	10.10	29	81859	79918	46524256
Cerebrovascular accident	64.91	10.10	349	81539	100690	46503484
Oedema peripheral	63.83	10.10	489	81399	159217	46444957
Pain	62.51	10.10	536	81352	476412	46127762
Exposure during pregnancy	61.97	10.10	59	81829	108153	46496021
Arthralgia	61.08	10.10	382	81506	364221	46239953
Renal impairment	60.67	10.10	275	81613	74097	46530077
Chest pain	57.15	10.10	515	81373	175809	46428365
Hypoglycaemia	56.92	10.10	217	81671	54132	46550042
Off label use	56.62	10.10	412	81476	379429	46224745
Drug intolerance	56.05	10.10	108	81780	146941	46457233
Drug hypersensitivity	54.01	10.10	232	81656	243593	46360581
Lower respiratory tract infection	53.73	10.10	15	81873	55074	46549100
Atrioventricular block	53.71	10.10	63	81825	6748	46597426
Musculoskeletal stiffness	53.16	10.10	56	81832	97937	46506237
Hypertensive crisis	50.68	10.10	88	81800	13527	46590647
Drug abuse	50.46	10.10	24	81864	63384	46540790
Cardioactive drug level increased	50.40	10.10	36	81852	2023	46602151
Systemic lupus erythematosus	49.87	10.10	26	81862	65154	46539020
Pulmonary oedema	49.42	10.10	199	81689	50906	46553268
Anaemia	48.87	10.10	673	81215	255106	46349068
Congestive cardiomyopathy	48.68	10.10	55	81833	5658	46598516
Injection site pain	46.95	10.10	72	81816	107080	46497094
Mental status changes	46.60	10.10	160	81728	37928	46566246
Blood glucose increased	46.40	10.10	249	81639	71764	46532410
Full blood count decreased	46.33	10.10	113	81775	22098	46582076
Abortion spontaneous	46.23	10.10	10	81878	43636	46560538
Death	45.28	10.10	833	81055	334715	46269459
Therapeutic product effect decreased	45.03	10.10	47	81841	82554	46521620
Fluid retention	44.84	10.10	193	81695	50853	46553321
Gastrointestinal tract mucosal pigmentation	43.59	10.10	21	81867	559	46603615
Cardiomegaly	41.99	10.10	94	81794	17388	46586786
Febrile neutropenia	41.05	10.10	64	81824	94563	46509611
Cardiac failure chronic	40.88	10.10	40	81848	3484	46600690
Ischaemic cardiomyopathy	40.78	10.10	35	81853	2575	46601599
Haemoglobin decreased	39.91	10.10	373	81515	128576	46475598
Pyrexia	39.58	10.10	406	81482	348396	46255778
Cardiac arrest	39.02	10.10	282	81606	90117	46514057
Unresponsive to stimuli	38.35	10.10	134	81754	32040	46572134
Dehydration	37.77	10.10	437	81451	159103	46445071
Blood loss anaemia	36.79	10.10	59	81829	8498	46595676
Cardiac failure acute	36.52	10.10	57	81831	8021	46596153
Rash	36.45	10.10	425	81463	356087	46248087
Ventricular arrhythmia	36.31	10.10	37	81851	3384	46600790
Coronary arterial stent insertion	36.16	10.10	34	81854	2819	46601355
Blood creatinine increased	35.11	10.10	242	81646	76161	46528013
Hepatic enzyme increased	34.83	10.10	56	81832	81731	46522443
Blood pressure decreased	34.37	10.10	194	81694	56965	46547209
Sinus bradycardia	34.11	10.10	75	81813	13707	46590467
Glycosylated haemoglobin increased	33.77	10.10	65	81823	10811	46593363
Pregnancy	33.70	10.10	4	81884	27133	46577041
Hypersensitivity	33.26	10.10	143	81745	150178	46453996
Fluid overload	33.08	10.10	114	81774	27071	46577103
Dizziness	32.87	10.10	805	81083	339609	46264565
Hand deformity	32.64	10.10	10	81878	34564	46569610
Arrhythmia	32.35	10.10	134	81754	34707	46569467
Mitral valve incompetence	32.21	10.10	89	81799	18763	46585411
Hypertension	32.08	10.10	503	81385	195853	46408321
Isosthenuria	31.78	10.10	11	81877	120	46604054
Orthopnoea	31.62	10.10	45	81843	5835	46598339
Renal disorder	30.82	10.10	110	81778	26576	46577598
Arthropathy	30.71	10.10	64	81824	84636	46519538
Glossodynia	30.68	10.10	20	81868	44353	46559821
Angina pectoris	30.61	10.10	110	81778	26665	46577509
Therapeutic product effect incomplete	30.10	10.10	57	81831	78096	46526078
Spinal epidural haematoma	29.59	10.10	18	81870	770	46603404
Injection site erythema	28.91	10.10	54	81834	74373	46529801
Myocardial ischaemia	28.90	10.10	67	81821	12682	46591492
Asthenia	28.35	10.10	730	81158	310345	46293829
Pyelitis	28.32	10.10	11	81877	170	46604004
Alopecia	28.24	10.10	168	81720	162246	46441928
Pulse absent	28.24	10.10	39	81849	4917	46599257
Glomerular filtration rate decreased	28.22	10.10	63	81825	11631	46592543
Electrocardiogram PR shortened	28.14	10.10	11	81877	173	46604001
Myxoedema coma	28.12	10.10	14	81874	401	46603773
Blood potassium increased	27.90	10.10	79	81809	16888	46587286
Asthma	27.76	10.10	76	81812	91466	46512708
Pericardial effusion	27.57	10.10	103	81785	25440	46578734
Drug interaction	27.25	10.10	504	81384	202590	46401584
Erythema	26.85	10.10	144	81744	142676	46461498
Bladder hypertrophy	26.14	10.10	11	81877	211	46603963
End stage renal disease	25.87	10.10	41	81847	5845	46598329
Suicidal ideation	25.54	10.10	37	81851	56345	46547829
Angina unstable	24.54	10.10	46	81842	7502	46596672
Neutropenia	23.91	10.10	150	81738	143054	46461120
Left ventricular hypertrophy	23.82	10.10	36	81852	4927	46599247
Migraine	23.67	10.10	55	81833	69971	46534203
Peritonitis bacterial	23.61	10.10	49	81839	8604	46595570
Ventricular hypokinesia	23.10	10.10	32	81856	4046	46600128
Headache	23.07	10.10	651	81237	477701	46126473
Atrioventricular block first degree	23.04	10.10	40	81848	6146	46598028
Infection	22.79	10.10	139	81749	133453	46470721
Intracardiac thrombus	22.77	10.10	24	81864	2284	46601890
Blood pressure inadequately controlled	22.64	10.10	33	81855	4373	46599801
Vessel puncture site haemorrhage	22.36	10.10	8	81880	97	46604077
Implantable defibrillator insertion	22.33	10.10	12	81876	404	46603770
Left ventricular dysfunction	22.27	10.10	53	81835	10202	46593972
Arterial stenosis	22.23	10.10	14	81874	637	46603537
Medication error	21.36	10.10	109	81779	30802	46573372
Injection site reaction	21.09	10.10	32	81856	47817	46556357
Blood glucose decreased	21.07	10.10	77	81811	18815	46585359
Dialysis	20.60	10.10	51	81837	10065	46594109
Leukopenia	20.53	10.10	57	81831	68286	46535888
Ventricular tachycardia	20.51	10.10	71	81817	16896	46587278
Acute respiratory failure	20.31	10.10	103	81785	29035	46575139
Ischaemic stroke	20.23	10.10	70	81818	16652	46587522
Fall	20.22	10.10	736	81152	328361	46275813
Blood pressure abnormal	20.20	10.10	57	81831	12160	46592014
Coronary artery occlusion	19.94	10.10	44	81844	8058	46596116
Brain natriuretic peptide increased	19.90	10.10	32	81856	4618	46599556
Tricuspid valve incompetence	19.82	10.10	61	81827	13656	46590518
Device expulsion	19.61	10.10	12	81876	27530	46576644
Diastolic dysfunction	19.43	10.10	34	81854	5258	46598916
Upper gastrointestinal haemorrhage	19.33	10.10	69	81819	16669	46587505
Respiratory failure	18.67	10.10	251	81637	94565	46509609
Urine albumin/creatinine ratio increased	18.57	10.10	8	81880	163	46604011
Atrial flutter	18.50	10.10	46	81842	9102	46595072
Urticaria	18.41	10.10	126	81762	117766	46486408
Basal ganglia haemorrhage	18.22	10.10	12	81876	590	46603584
Creatinine renal clearance increased	17.92	10.10	11	81877	478	46603696
Aortic valve incompetence	17.71	10.10	35	81853	5935	46598239
Red blood cell sedimentation rate increased	17.70	10.10	9	81879	22880	46581294
Arteriosclerosis	17.68	10.10	47	81841	9686	46594488
Pericarditis	17.63	10.10	10	81878	23917	46580257
Foetal exposure during pregnancy	17.31	10.10	17	81871	30730	46573444
Electrocardiogram QT shortened	17.20	10.10	7	81881	123	46604051
Atrioventricular block complete	17.19	10.10	40	81848	7587	46596587
Melaena	17.18	10.10	95	81793	27677	46576497
Lower gastrointestinal haemorrhage	17.17	10.10	39	81849	7281	46596893
Renal hypoplasia	16.92	10.10	5	81883	31	46604143
Femoral artery dissection	16.92	10.10	5	81883	31	46604143
Injection site swelling	16.80	10.10	28	81860	40299	46563875
Cardiogenic shock	16.80	10.10	65	81823	16319	46587855
Genotype drug resistance test positive	16.74	10.10	11	81877	539	46603635
Pulseless electrical activity	16.61	10.10	38	81850	7129	46597045
Intentional self-injury	16.56	10.10	11	81877	24155	46580019
Blood urea increased	16.55	10.10	88	81800	25264	46578910
Hypertensive emergency	16.27	10.10	17	81871	1601	46602573
Oropharyngeal pain	16.12	10.10	71	81817	74097	46530077
Electrocardiogram ST segment	16.04	10.10	3	81885	0	46604174
Vena cava injury	16.04	10.10	3	81885	0	46604174
Product use in unapproved indication	15.88	10.10	93	81795	90180	46513994
Tendonitis	15.68	10.10	3	81885	14274	46589900
Pleural effusion	15.67	10.10	218	81670	82734	46521440
Nephropathy	15.65	10.10	30	81858	4975	46599199
Nephrogenic anaemia	15.59	10.10	18	81870	1895	46602279
Hypouricaemia	15.59	10.10	7	81881	158	46604016
Chronic obstructive pulmonary disease	15.51	10.10	162	81726	57471	46546703
Platelet dysfunction	15.37	10.10	6	81882	94	46604080
Renal injury	15.27	10.10	44	81844	9497	46594677
Hypovolaemia	15.25	10.10	45	81843	9843	46594331
Cerebral infarction	15.18	10.10	81	81807	23285	46580889
Toxic neuropathy	14.96	10.10	9	81879	377	46603797
Impaired healing	14.86	10.10	26	81862	36717	46567457
Product use issue	14.85	10.10	101	81787	94543	46509631
Mucocutaneous haemorrhage	14.41	10.10	5	81883	55	46604119
Pernicious anaemia	14.36	10.10	11	81877	688	46603486
Haematocrit decreased	14.34	10.10	108	81780	34949	46569225
Vascular stent stenosis	14.25	10.10	10	81878	546	46603628
Calcium deficiency	14.24	10.10	12	81876	861	46603313
Embolic stroke	14.17	10.10	24	81864	3615	46600559
Left ventricular dilatation	14.13	10.10	8	81880	299	46603875
Bone marrow failure	13.90	10.10	19	81869	29650	46574524
Blood pressure increased	13.86	10.10	305	81583	126361	46477813
Pulmonary congestion	13.80	10.10	57	81831	14742	46589432
Insulin-requiring type 2 diabetes mellitus	13.80	10.10	5	81883	63	46604111
Anti-neutrophil cytoplasmic antibody positive vasculitis	13.79	10.10	17	81871	1918	46602256
Abdominal pain	13.76	10.10	303	81585	229728	46374446
Herbal interaction	13.73	10.10	5	81883	64	46604110
Hypervolaemia	13.70	10.10	16	81872	1706	46602468
Suicide attempt	13.65	10.10	50	81838	54986	46549188
Carbohydrate antigen 15-3 increased	13.65	10.10	12	81876	912	46603262
Injection site pruritus	13.60	10.10	31	81857	39712	46564462
Urinary tract infection	13.60	10.10	493	81395	219773	46384401
Coronary artery bypass	13.57	10.10	19	81869	2426	46601748
Wound	13.38	10.10	35	81853	42767	46561407
Tremor	13.31	10.10	134	81754	115505	46488669
Therapy cessation	13.22	10.10	86	81802	26543	46577631
Renal artery stenosis	13.21	10.10	16	81872	1772	46602402
Shock	13.03	10.10	74	81814	21771	46582403
Malignant neoplasm progression	13.02	10.10	64	81824	64862	46539312
Unevaluable event	13.00	10.10	131	81757	46044	46558130
Renal tubular injury	12.99	10.10	8	81880	350	46603824
Herpes zoster	12.98	10.10	68	81820	67804	46536370
Cytomegalovirus infection	12.78	10.10	8	81880	18136	46586038
Psoriatic arthropathy	12.75	10.10	28	81860	36351	46567823
Cholestatic liver injury	12.75	10.10	17	81871	2073	46602101
Sinusitis	12.71	10.10	156	81732	129612	46474562
Condition aggravated	12.67	10.10	330	81558	244722	46359452
Hypertensive encephalopathy	12.57	10.10	10	81878	661	46603513
Abdominal discomfort	12.54	10.10	188	81700	150977	46453197
Decreased appetite	12.49	10.10	436	81452	193400	46410774
Cognitive disorder	12.43	10.10	29	81859	36854	46567320
Plasma cell myeloma	12.43	10.10	126	81762	44352	46559822
Transfusion	12.37	10.10	51	81837	13180	46590994
Catheterisation cardiac	12.34	10.10	24	81864	4023	46600151
Cardiac operation	12.32	10.10	19	81869	2647	46601527
Nasopharyngitis	12.27	10.10	193	81695	153805	46450369
Renal atrophy	12.10	10.10	13	81875	1264	46602910
Agitation	12.07	10.10	53	81835	55362	46548812
Glomerulonephritis rapidly progressive	12.07	10.10	10	81878	701	46603473
Anaphylactic reaction	12.06	10.10	50	81838	53062	46551112
Foot deformity	12.02	10.10	6	81882	15419	46588755
Basal cell carcinoma	11.92	10.10	11	81877	20476	46583698
Occult blood positive	11.91	10.10	22	81866	3548	46600626
Traumatic renal injury	11.90	10.10	3	81885	9	46604165
Electrocardiogram abnormal	11.87	10.10	33	81855	6979	46597195
Haemorrhage intracranial	11.86	10.10	49	81839	12675	46591499
Oral herpes	11.77	10.10	10	81878	19380	46584794
Bradyarrhythmia	11.75	10.10	16	81872	1990	46602184
Phaeochromocytoma crisis	11.74	10.10	6	81882	182	46603992
Arterial occlusive disease	11.72	10.10	26	81862	4778	46599396
Bundle branch block left	11.72	10.10	31	81857	6368	46597806
Peripheral coldness	11.70	10.10	41	81847	9814	46594360
Breast cancer recurrent	11.69	10.10	23	81865	3888	46600286
Gastrointestinal arteriovenous malformation	11.65	10.10	9	81879	570	46603604
Gout	11.60	10.10	45	81843	11311	46592863
Refractory anaemia with an excess of blasts	11.56	10.10	8	81880	427	46603747
Hypovolaemic shock	11.48	10.10	27	81861	5156	46599018
Intercepted product dispensing error	11.42	10.10	5	81883	106	46604068
Pneumonia	11.41	10.10	786	81102	375534	46228640
Chronic left ventricular failure	11.37	10.10	7	81881	306	46603868
Multiple sclerosis relapse	11.31	10.10	37	81851	42088	46562086
Subdural haematoma	11.30	10.10	49	81839	12948	46591226
Drug dependence	11.21	10.10	11	81877	19890	46584284
Bursitis	11.14	10.10	11	81877	19831	46584343
Extrapyramidal disorder	11.11	10.10	3	81885	11265	46592909
Carcinoembryonic antigen increased	11.05	10.10	13	81875	1396	46602778
Aortic stenosis	11.02	10.10	24	81864	4358	46599816
Loss of consciousness	11.01	10.10	258	81630	107980	46496194
Arthritis	10.92	10.10	85	81803	77231	46526943
Arteriovenous fistula thrombosis	10.90	10.10	6	81882	212	46603962
Epinephrine increased	10.86	10.10	3	81885	14	46604160
Photophobia	10.83	10.10	6	81882	14538	46589636
Supraventricular extrasystoles	10.82	10.10	23	81865	4106	46600068
Breath sounds	10.70	10.10	5	81883	124	46604050
Metabolic acidosis	10.43	10.10	109	81779	38671	46565503
Neutrophil count decreased	10.41	10.10	40	81848	43386	46560788
Quadriplegia	10.40	10.10	14	81874	1723	46602451
Injection site urticaria	10.36	10.10	4	81884	11963	46592211
Post procedural hypothyroidism	10.35	10.10	5	81883	134	46604040
Long QT syndrome	10.30	10.10	19	81869	3061	46601113
Hepatic vein dilatation	10.24	10.10	3	81885	18	46604156
Premature baby	10.21	10.10	10	81878	18102	46586072
Cardiac pacemaker insertion	10.16	10.10	21	81867	3678	46600496
Retinopathy hypertensive	10.14	10.10	6	81882	244	46603930

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure congestive	1092.36	10.53	1332	92489	83075	29775582
Cardiac failure	384.22	10.53	823	92998	82595	29776062
Myocardial infarction	356.78	10.53	1030	92791	124595	29734062
Hypotension	298.41	10.53	1330	92491	199235	29659422
Bradycardia	231.64	10.53	583	93238	64943	29793714
Coronary artery disease	147.88	10.53	415	93406	49297	29809360
Drug abuse	141.06	10.53	41	93780	82031	29776626
Acute myocardial infarction	135.56	10.53	419	93402	52520	29806137
Ejection fraction decreased	123.69	10.53	192	93629	14983	29843674
Syncope	123.41	10.53	560	93261	84343	29774314
Hyperkalaemia	121.43	10.53	468	93353	65542	29793115
Cardiac failure chronic	114.38	10.53	115	93706	5748	29852909
Ischaemic cardiomyopathy	111.07	10.53	117	93704	6180	29852477
Dizziness	109.30	10.53	1009	92812	193900	29664757
Atrial fibrillation	97.67	10.53	626	93195	107498	29751159
Cardiac failure acute	94.63	10.53	130	93691	9079	29849578
Off label use	93.19	10.53	433	93388	248857	29609800
Dyspnoea	91.70	10.53	1508	92313	331787	29526870
Gastrointestinal haemorrhage	89.94	10.53	506	93315	82940	29775717
Foetal exposure during pregnancy	86.20	10.53	8	93813	36863	29821794
Cardiac disorder	86.11	10.53	298	93523	39595	29819062
Pyrexia	85.68	10.53	556	93265	293933	29564724
Cardiomyopathy	79.62	10.53	158	93663	14985	29843672
Neutropenia	77.98	10.53	180	93641	128360	29730297
Ventricular tachycardia	73.66	10.53	202	93619	23660	29834997
Rheumatoid arthritis	71.82	10.53	20	93801	41177	29817480
Mitral valve incompetence	68.27	10.53	137	93684	13097	29845560
International normalised ratio increased	67.88	10.53	313	93508	47426	29811231
Febrile neutropenia	66.65	10.53	147	93674	106546	29752111
Drug ineffective	65.77	10.53	716	93105	339671	29518986
Chronic kidney disease	62.88	10.53	260	93561	37578	29821079
Left ventricular dilatation	59.04	10.53	32	93789	600	29858057
Blood pressure decreased	51.02	10.53	286	93535	46789	29811868
Blood potassium increased	49.78	10.53	137	93684	16076	29842581
Cerebrovascular accident	49.60	10.53	438	93383	83039	29775618
Treatment failure	48.43	10.53	24	93797	34655	29824002
Cardiomegaly	47.97	10.53	126	93695	14383	29844274
Hypoglycaemia	45.84	10.53	295	93526	50686	29807971
Toxicity to various agents	44.79	10.53	348	93473	176835	29681822
Pulmonary oedema	44.28	10.53	262	93559	43713	29814944
Renal impairment	43.62	10.53	429	93392	83755	29774902
Coronary artery bypass	43.02	10.53	66	93755	5096	29853561
Ventricular hypokinesia	42.46	10.53	59	93762	4164	29854493
Drug reaction with eosinophilia and systemic symptoms	42.45	10.53	18	93803	28470	29830187
Angina pectoris	42.29	10.53	194	93627	29324	29829333
Blood creatinine increased	41.82	10.53	454	93367	90921	29767736
Coronary arterial stent insertion	41.28	10.53	58	93763	4136	29854521
Cardiogenic shock	40.85	10.53	131	93690	16730	29841927
Orthopnoea	40.61	10.53	60	93761	4480	29854177
Blood loss anaemia	40.59	10.53	80	93741	7547	29851110
Chest pain	38.97	10.53	550	93271	117077	29741580
Product use in unapproved indication	38.64	10.53	111	93710	73582	29785075
Acute kidney injury	38.26	10.53	1125	92696	272717	29585940
Presyncope	38.22	10.53	124	93697	15932	29842725
N-terminal prohormone brain natriuretic peptide abnormal	37.72	10.53	14	93807	100	29858557
Agitation	37.57	10.53	70	93751	54003	29804654
Suicidal ideation	35.94	10.53	36	93785	36078	29822579
Atrioventricular block	35.91	10.53	74	93747	7208	29851449
Premature baby	35.56	10.53	5	93816	16686	29841971
Completed suicide	35.30	10.53	471	93350	99021	29759636
Carotid sinus syndrome	34.43	10.53	10	93811	28	29858629
Aggression	34.26	10.53	39	93782	36868	29821789
Fluid retention	34.12	10.53	162	93659	24836	29833821
Hepatocellular injury	33.54	10.53	19	93802	25452	29833205
Fractured coccyx	33.21	10.53	14	93807	145	29858512
Depression	33.12	10.53	158	93663	90279	29768378
Leukopenia	32.92	10.53	80	93741	56079	29802578
Malignant neoplasm progression	32.91	10.53	116	93705	72171	29786486
Suicide attempt	32.75	10.53	40	93781	36657	29822000
Drug dependence	32.46	10.53	13	93808	21282	29837375
Cardiac arrest	32.30	10.53	438	93383	92412	29766245
Bradyarrhythmia	32.18	10.53	35	93786	1917	29856740
Blood thyroid stimulating hormone abnormal	31.99	10.53	14	93807	160	29858497
Cardioactive drug level increased	31.69	10.53	32	93789	1607	29857050
Intentional overdose	31.27	10.53	51	93770	41430	29817227
Asthenia	30.83	10.53	909	92912	220381	29638276
Mouth breathing	29.35	10.53	11	93810	81	29858576
Heart rate decreased	29.34	10.53	137	93684	20857	29837800
Congestive cardiomyopathy	28.83	10.53	64	93757	6563	29852094
Brain natriuretic peptide abnormal	28.71	10.53	13	93808	162	29858495
Mucosal inflammation	28.54	10.53	32	93789	30462	29828195
Electrocardiogram QRS complex abnormal	28.32	10.53	15	93806	268	29858389
Cholestasis	28.28	10.53	22	93799	24928	29833729
Bundle branch block left	28.20	10.53	55	93766	5149	29853508
Sinus arrest	28.16	10.53	29	93792	1491	29857166
Nodal rhythm	27.92	10.53	28	93793	1395	29857262
Renal failure	27.00	10.53	560	93261	128406	29730251
Nodal arrhythmia	26.97	10.53	22	93799	835	29857822
Arrhythmia	26.84	10.53	187	93634	32982	29825675
Generalised tonic-clonic seizure	26.59	10.53	14	93807	19537	29839120
Alanine aminotransferase increased	26.47	10.53	131	93690	74145	29784512
Shock	26.18	10.53	141	93680	22718	29835939
Ventricular fibrillation	25.91	10.53	105	93716	15033	29843624
Sudden cardiac death	25.84	10.53	44	93777	3708	29854949
Oxygen saturation increased	25.76	10.53	13	93808	209	29858448
Pulmonary arterial pressure abnormal	25.26	10.53	12	93809	168	29858489
Infusion related reaction	25.21	10.53	56	93765	40508	29818149
Blood glucose decreased	25.16	10.53	94	93727	12959	29845698
Lower respiratory tract infection	25.04	10.53	28	93793	26686	29831971
Arthralgia	24.75	10.53	289	93532	135502	29723155
Rash maculo-papular	24.54	10.53	26	93795	25392	29833265
Blood pressure inadequately controlled	24.49	10.53	35	93786	2535	29856122
Oedema peripheral	24.30	10.53	466	93355	105366	29753291
Haemorrhage intracranial	23.95	10.53	102	93719	14930	29843727
Pancytopenia	23.88	10.53	162	93659	84890	29773767
Thrombocytopenia	23.71	10.53	295	93526	136749	29721908
Blood urea increased	23.69	10.53	174	93647	31207	29827450
Seizure	23.65	10.53	196	93625	98279	29760378
Pulmonary hypertension	23.57	10.53	120	93701	18916	29839741
Orthostatic hypotension	23.57	10.53	142	93679	23837	29834820
Hypertensive crisis	23.10	10.53	68	93753	8289	29850368
Cytomegalovirus infection	23.09	10.53	24	93797	23650	29835007
Rash	23.02	10.53	443	93378	191446	29667211
End stage renal disease	22.99	10.53	63	93758	7372	29851285
Neutrophil count decreased	22.94	10.53	63	93758	42391	29816266
Agranulocytosis	22.84	10.53	21	93800	21921	29836736
Ventricular internal diameter abnormal	22.74	10.53	8	93813	48	29858609
Fluid overload	22.70	10.53	119	93702	18973	29839684
Oesophageal discomfort	22.46	10.53	8	93813	50	29858607
Tricuspid valve incompetence	21.80	10.53	68	93753	8555	29850102
Jugular vein distension	21.65	10.53	16	93805	524	29858133
Full blood count decreased	21.55	10.53	102	93719	15615	29843042
Osteonecrosis	21.29	10.53	12	93809	16123	29842534
Drug resistance	21.28	10.53	19	93802	20114	29838543
Coma	21.14	10.53	61	93760	40388	29818269
Conjunctival scar	21.00	10.53	8	93813	62	29858595
C-reactive protein increased	20.98	10.53	68	93753	43405	29815252
Candida infection	20.89	10.53	11	93810	15351	29843306
Blood glucose increased	20.86	10.53	289	93532	61241	29797416
Neutrophil count increased	20.80	10.53	11	93810	15312	29843345
Angina unstable	20.76	10.53	85	93736	12225	29846432
Drug withdrawal syndrome	20.57	10.53	19	93802	19790	29838867
Suspected suicide	20.38	10.53	36	93785	3125	29855532
Bundle branch block	20.27	10.53	19	93802	870	29857787
Neuroleptic malignant syndrome	20.27	10.53	13	93808	16282	29842375
Epilepsy	20.18	10.53	20	93801	20149	29838508
Eosinophilia	19.94	10.53	24	93797	22136	29836521
Sinus bradycardia	19.92	10.53	81	93740	11614	29847043
Gingival hypertrophy	19.78	10.53	25	93796	1608	29857049
Cerebral infarction	19.78	10.53	146	93675	26227	29832430
Psychotic disorder	19.68	10.53	23	93798	21492	29837165
Graft versus host disease	19.51	10.53	4	93817	10146	29848511
Upper gastrointestinal haemorrhage	19.50	10.53	127	93694	21901	29836756
Bone marrow failure	19.44	10.53	40	93781	29745	29828912
Diastolic dysfunction	19.43	10.53	42	93779	4229	29854428
Cardiac pacemaker insertion	19.08	10.53	31	93790	2514	29856143
Abnormal behaviour	18.85	10.53	32	93789	25591	29833066
Immune reconstitution inflammatory syndrome	18.76	10.53	3	93818	9098	29849559
Nephrogenic anaemia	18.75	10.53	28	93793	2111	29856546
Fall	18.64	10.53	721	93100	181151	29677506
Dyspnoea exertional	18.54	10.53	181	93640	35249	29823408
Musculoskeletal stiffness	18.10	10.53	55	93766	35826	29822831
Overdose	17.98	10.53	173	93648	84164	29774493
Bronchopulmonary aspergillosis	17.92	10.53	8	93813	12276	29846381
Injection site pain	17.90	10.53	43	93778	30267	29828390
Sedation	17.85	10.53	15	93806	16358	29842299
Erythema	17.76	10.53	156	93665	77295	29781362
Serotonin syndrome	17.61	10.53	18	93803	17873	29840784
Torsade de pointes	17.54	10.53	56	93765	7134	29851523
Periodontitis	17.39	10.53	24	93797	1683	29856974
Implantable defibrillator insertion	17.38	10.53	16	93805	716	29857941
Neutropenic sepsis	17.33	10.53	7	93814	11402	29847255
Hepatitis	17.30	10.53	27	93794	22329	29836328
Atrioventricular block complete	17.14	10.53	62	93759	8415	29850242
Lymphopenia	17.07	10.53	10	93811	13153	29845504
Atrioventricular block second degree	16.79	10.53	33	93788	3107	29855550
Pulmonary renal syndrome	16.78	10.53	9	93812	165	29858492
Intentional self-injury	16.55	10.53	11	93810	13521	29845136
Schizophrenia	16.51	10.53	4	93817	9044	29849613
Brain natriuretic peptide increased	16.47	10.53	38	93783	3997	29854660
Progressive multifocal leukoencephalopathy	16.42	10.53	4	93817	9009	29849648
Arterial spasm	16.35	10.53	8	93813	120	29858537
Left atrial dilatation	16.29	10.53	24	93797	1787	29856870
Therapeutic product effect incomplete	16.27	10.53	53	93768	33781	29824876
Cardio-respiratory arrest	16.24	10.53	261	93560	57045	29801612
Tachycardia induced cardiomyopathy	16.15	10.53	7	93814	78	29858579
Oedema	15.84	10.53	205	93616	42788	29815869
Gallbladder oedema	15.70	10.53	9	93812	189	29858468
Lymphadenopathy	15.68	10.53	33	93788	24343	29834314
Vascular graft	15.64	10.53	21	93800	1434	29857223
Concomitant disease progression	15.35	10.53	28	93793	2492	29856165
Shunt occlusion	15.25	10.53	14	93807	624	29858033
Infective pulmonary exacerbation of cystic fibrosis	15.24	10.53	4	93817	8568	29850089
Pulmonary arterial pressure increased	15.15	10.53	18	93803	1086	29857571
Cardioversion	15.11	10.53	16	93805	850	29857807
Hallucination	15.01	10.53	91	93730	48968	29809689
Hypovolaemia	14.97	10.53	60	93761	8545	29850112
Haemophagocytic lymphohistiocytosis	14.88	10.53	6	93815	9785	29848872
Aspartate aminotransferase increased	14.87	10.53	127	93694	63295	29795362
Vomiting	14.86	10.53	551	93270	219267	29639390
Pathogen resistance	14.81	10.53	4	93817	8406	29850251
Subdural haematoma	14.78	10.53	106	93715	18866	29839791
Pulmonary embolism	14.72	10.53	165	93656	77970	29780687
Death	14.68	10.53	1304	92517	355979	29502678
Embolic stroke	14.67	10.53	34	93787	3588	29855069
Respiratory depression	14.55	10.53	9	93812	11494	29847163
Liver palpable	14.50	10.53	6	93815	59	29858598
Cerebral haemorrhage	14.38	10.53	162	93659	32725	29825932
Aspergillus infection	14.36	10.53	7	93814	10207	29848450
Intentional product use issue	14.32	10.53	62	93759	36378	29822279
Pulse waveform abnormal	14.31	10.53	3	93818	0	29858657
Cardioactive drug level above therapeutic	14.24	10.53	6	93815	62	29858595
Gastrointestinal endoscopic therapy	14.10	10.53	4	93817	10	29858647
Osteonecrosis of jaw	13.93	10.53	23	93798	18595	29840062
Pneumocystis jirovecii pneumonia	13.91	10.53	20	93801	17100	29841557
Left ventricular dysfunction	13.86	10.53	59	93762	8632	29850025
Symblepharon	13.85	10.53	7	93814	113	29858544
Gravitational oedema	13.84	10.53	13	93808	597	29858060
Tumour lysis syndrome	13.81	10.53	12	93809	12873	29845784
Myocardial ischaemia	13.63	10.53	97	93724	17220	29841437
Anti-neutrophil cytoplasmic antibody positive vasculitis	13.61	10.53	13	93808	610	29858047
Conduction disorder	13.60	10.53	23	93798	1928	29856729
Drug hypersensitivity	13.59	10.53	143	93678	68376	29790281
Acute pulmonary oedema	13.56	10.53	53	93768	7462	29851195
Tremor	13.48	10.53	161	93660	75202	29783455
Urticaria	13.41	10.53	108	93713	54498	29804159
Ventricular extrasystoles	13.29	10.53	71	93750	11403	29847254
Cardiac aneurysm	13.21	10.53	13	93808	633	29858024
Cerebellar haemorrhage	13.20	10.53	19	93802	1385	29857272
Heart rate abnormal	13.19	10.53	20	93801	1528	29857129
Substance abuse	13.07	10.53	3	93818	7037	29851620
Dyspnoea paroxysmal nocturnal	12.81	10.53	17	93804	1148	29857509
Extrapyramidal disorder	12.67	10.53	9	93812	10684	29847973
Cholangitis sclerosing	12.63	10.53	15	93806	905	29857752
Disturbance in attention	12.59	10.53	32	93789	22097	29836560
Dizziness postural	12.53	10.53	42	93779	5488	29853169
Arteriosclerosis	12.52	10.53	67	93754	10766	29847891
Confusional state	12.51	10.53	324	93497	134510	29724147
Human ehrlichiosis	12.51	10.53	8	93813	206	29858451
Mouth ulceration	12.48	10.53	9	93812	10600	29848057
Cardiac dysfunction	12.45	10.53	17	93804	1180	29857477
Thyroiditis	12.42	10.53	20	93801	1609	29857048
Hypoglycaemic unconsciousness	12.37	10.53	14	93807	802	29857855
Anger	12.36	10.53	10	93811	11110	29847547
Oral candidiasis	12.25	10.53	10	93811	11061	29847596
Internal haemorrhage	12.24	10.53	36	93785	4386	29854271
Dilatation atrial	12.22	10.53	23	93798	2096	29856561
Intracardiac thrombus	12.22	10.53	25	93796	2423	29856234
Chronic left ventricular failure	12.20	10.53	10	93811	382	29858275
Asthma	12.20	10.53	65	93756	36109	29822548
Epstein-Barr virus infection	12.17	10.53	3	93818	6703	29851954
Hydrothorax	12.16	10.53	11	93810	481	29858176
Toxic skin eruption	12.12	10.53	10	93811	11005	29847652
Ejection fraction abnormal	12.04	10.53	13	93808	706	29857951
Troponin I increased	11.98	10.53	21	93800	1812	29856845
Chills	11.65	10.53	158	93663	72180	29786477
Cogwheel rigidity	11.61	10.53	16	93805	1120	29857537
Cardiac output decreased	11.61	10.53	14	93807	858	29857799
Colitis ulcerative	11.59	10.53	17	93804	14417	29844240
Ventricular dyskinesia	11.57	10.53	7	93814	163	29858494
Coronary artery occlusion	11.56	10.53	67	93754	11090	29847567
Peripheral arterial occlusive disease	11.48	10.53	39	93782	5129	29853528
Eczema	11.48	10.53	15	93806	13354	29845303
Toxic goitre	11.38	10.53	3	93818	5	29858652
Lower gastrointestinal haemorrhage	11.35	10.53	52	93769	7852	29850805
Procedural hypotension	11.34	10.53	15	93806	1010	29857647
Haematochezia	11.29	10.53	160	93661	34062	29824595
Melaena	11.25	10.53	153	93668	32284	29826373
Inspiratory capacity decreased	11.19	10.53	6	93815	110	29858547
Periorbital haemorrhage	11.19	10.53	6	93815	110	29858547
Haemorrhagic cerebral infarction	11.09	10.53	13	93808	773	29857884
Incarcerated hernia	11.06	10.53	7	93814	177	29858480
Fatigue	11.02	10.53	1156	92665	319517	29539140
Atrioventricular block first degree	10.99	10.53	41	93780	5647	29853010
Peritonitis bacterial	10.94	10.53	67	93754	11311	29847346
Loss of personal independence in daily activities	10.87	10.53	33	93788	21502	29837155
Gout	10.86	10.53	92	93729	17223	29841434
Posterior reversible encephalopathy syndrome	10.76	10.53	7	93814	8700	29849957
Breath odour	10.71	10.53	13	93808	802	29857855
Dilatation ventricular	10.68	10.53	25	93796	2655	29856002
Blood pressure increased	10.67	10.53	298	93523	71630	29787027
Dyskinesia	10.64	10.53	34	93787	21800	29836857
Jaundice	10.61	10.53	59	93762	32427	29826230
Bronchostenosis	10.59	10.53	8	93813	271	29858386
Goitre	10.56	10.53	18	93803	1518	29857139
Acute generalised exanthematous pustulosis	10.55	10.53	3	93818	6095	29852562

Pharmacologic Action:

Source	Code	Description
ATC	C07AG02	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Alpha and beta blocking agents
ATC	C07FX06	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations
FDA MoA	N0000000099	Adrenergic alpha-Antagonists
FDA MoA	N0000009923	Adrenergic beta1-Antagonists
FDA MoA	N0000009924	Adrenergic beta2-Antagonists
FDA EPC	N0000175553	alpha-Adrenergic Blocker
FDA EPC	N0000175556	beta-Adrenergic Blocker
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D058668	Adrenergic alpha-1 Receptor Antagonists
MeSH PA	D000317	Adrenergic alpha-Antagonists
MeSH PA	D018674	Adrenergic Antagonists
MeSH PA	D000319	Adrenergic beta-Antagonists
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D000975	Antioxidants
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D014665	Vasodilator Agents
CHEBI has role	CHEBI:35530	beta-adrenoceptor antagonists
CHEBI has role	CHEBI:35554	cardiovascular drugs
CHEBI has role	CHEBI:35620	vasodilator
CHEBI has role	CHEBI:35674	antihypertensive
CHEBI has role	CHEBI:37890	alpha-adrenoceptor antagonists

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Chronic heart failure	indication	48447003
Left ventricular cardiac dysfunction	indication	429589006
Atrial fibrillation	off-label use	49436004	DOID:0060224
Diastolic heart failure	off-label use	418304008	DOID:9775
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation	off-label use
Bronchospasm	contraindication	4386001
Complete atrioventricular block	contraindication	27885002
Sick sinus syndrome	contraindication	36083008	DOID:13884
Anaphylaxis	contraindication	39579001
Low blood pressure	contraindication	45007003
Sinus bradycardia	contraindication	49710005
Hepatic failure	contraindication	59927004
Chronic bronchitis	contraindication	63480004	DOID:6132
Diabetes mellitus	contraindication	73211009	DOID:9351
Prinzmetal angina	contraindication	87343002
Pulmonary emphysema	contraindication	87433001
Cardiogenic shock	contraindication	89138009
Second degree atrioventricular block	contraindication	195042002
Asthma	contraindication	195967001	DOID:2841
Pregnancy, function	contraindication	289908002
Peripheral vascular disease	contraindication	400047006
Intraoperative floppy iris syndrome	contraindication	418801006
Acutely Decompensated HF Requiring Parenteral Inotropic Therapy	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.13	acidic
pKa2	7.88	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN	ANTAGONIST	Ki	9.90		IUPHAR	CHEMBL
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN	ANTAGONIST	Ki	9.50		IUPHAR	CHEMBL
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN	ANTAGONIST	Ki	9.40		IUPHAR
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	6.13		DRUG MATRIX
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	7.31		DRUG MATRIX
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	7.40		DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	6.93		DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	6.27		DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	8.48		DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.93		DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	7.82		DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	7.22		DRUG MATRIX
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	6.15		DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	7.37		DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.71		DRUG MATRIX
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	7.89		DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	6.17		DRUG MATRIX
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN	ANTAGONIST	Ki	9.05		DRUG MATRIX
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN	ANTAGONIST	Ki	8.66		WOMBAT-PK
Solute carrier family 22 member 2	Transporter	O15244	S22A2_HUMAN		IC50	5.12		CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	6.46		CHEMBL
Multidrug and toxin extrusion protein 1	Transporter	Q96FL8	S47A1_HUMAN		IC50	4.03		CHEMBL
Amyloid beta A4 protein	Unclassified	P05067	A4_HUMAN		IC50	4.52		CHEMBL
5-hydroxytryptamine receptor 4	GPCR		5HT4R_CAVPO		Ki	6.74		DRUG MATRIX
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	8.71		DRUG MATRIX
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT		Ki	6.23		DRUG MATRIX
Beta-1 adrenergic receptor	GPCR		ADRB1_RAT		Ki	9.09		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	8.50		CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	8.11		CHEMBL

External reference:

ID	Source
4021041	VUID
N0000148505	NUI
D00255	KEGG_DRUG
374779-41-6	SECONDARY_CAS_RN
4021041	VANDF
4026028	VANDF
C0054836	UMLSCUI
CHEBI:3441	CHEBI
CVD	PDB_CHEM_ID
CHEMBL723	ChEMBL_ID
CHEMBL1201167	ChEMBL_ID
DB01136	DRUGBANK_ID
D000077261	MESH_DESCRIPTOR_UI
5333	INN_ID
2585	PUBCHEM_CID
551	IUPHAR_LIGAND_ID
0K47UL67F2	UNII
20352	RXNORM
119032	MMSL
22339	MMSL
265288	MMSL
4363	MMSL
d03847	MMSL
004167	NDDF
011844	NDDF
108551001	SNOMEDCT_US
386870007	SNOMEDCT_US
426471008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-4139	TABLET, FILM COATED	3.13 mg	ORAL	NDA	26 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-4140	TABLET, FILM COATED	6.25 mg	ORAL	NDA	26 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-4141	TABLET, FILM COATED	12.50 mg	ORAL	NDA	26 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-4142	TABLET, FILM COATED	25 mg	ORAL	NDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0051	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0135	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7295	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7296	TABLET, FILM COATED	25 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3631	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3632	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3633	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3634	TABLET, FILM COATED	25 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7944	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	27 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7945	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	27 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7946	TABLET, FILM COATED	25 mg	ORAL	ANDA	27 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8018	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	27 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8387	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8388	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8389	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8390	TABLET, FILM COATED	25 mg	ORAL	ANDA	26 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5221	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	25 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5222	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	25 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5223	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	25 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5224	TABLET, FILM COATED	25 mg	ORAL	ANDA	25 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6300	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	25 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6301	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	25 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6302	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	25 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6303	TABLET, FILM COATED	25 mg	ORAL	ANDA	25 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	10135-633	TABLET	3.13 mg	ORAL	ANDA	25 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	10135-634	TABLET	6.25 mg	ORAL	ANDA	25 sections