carvedilol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| vasodilators | 522 | 72956-09-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 37.50 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.01 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 1 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.03 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 7.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.40 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 14, 1995 | FDA | SMITHKLINE BEECHAM |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cardiac failure congestive | 1156.38 | 9.94 | 1061 | 86456 | 91696 | 53169853 |
| Myocardial infarction | 371.20 | 9.94 | 619 | 86898 | 98735 | 53162814 |
| Cardiac failure | 323.49 | 9.94 | 537 | 86980 | 85307 | 53176242 |
| Rheumatoid arthritis | 280.57 | 9.94 | 84 | 87433 | 314447 | 52947102 |
| Hypotension | 262.82 | 9.94 | 964 | 86553 | 253112 | 53008437 |
| Drug ineffective | 223.59 | 9.94 | 649 | 86868 | 816596 | 52444953 |
| Bradycardia | 216.45 | 9.94 | 405 | 87112 | 70651 | 53190898 |
| Acute myocardial infarction | 160.13 | 9.94 | 233 | 87284 | 33002 | 53228547 |
| Cardiomyopathy | 146.82 | 9.94 | 160 | 87357 | 16928 | 53244621 |
| Hyperkalaemia | 144.16 | 9.94 | 292 | 87225 | 53964 | 53207585 |
| Acute kidney injury | 136.94 | 9.94 | 796 | 86721 | 253072 | 53008477 |
| Treatment failure | 136.90 | 9.94 | 23 | 87494 | 128380 | 53133169 |
| Synovitis | 130.20 | 9.94 | 13 | 87504 | 107880 | 53153669 |
| Joint swelling | 126.63 | 9.94 | 119 | 87398 | 234519 | 53027030 |
| Maternal exposure during pregnancy | 122.41 | 9.94 | 51 | 87466 | 155588 | 53105961 |
| Systemic lupus erythematosus | 122.07 | 9.94 | 28 | 87489 | 125386 | 53136163 |
| Infusion related reaction | 119.64 | 9.94 | 53 | 87464 | 155904 | 53105645 |
| Ejection fraction decreased | 117.94 | 9.94 | 154 | 87363 | 19694 | 53241855 |
| Gastrointestinal haemorrhage | 115.24 | 9.94 | 341 | 87176 | 79989 | 53181560 |
| Chronic kidney disease | 114.70 | 9.94 | 233 | 87284 | 43137 | 53218412 |
| Contraindicated product administered | 114.04 | 9.94 | 40 | 87477 | 135589 | 53125960 |
| Coronary artery disease | 108.57 | 9.94 | 196 | 87321 | 33241 | 53228308 |
| Atrial fibrillation | 104.64 | 9.94 | 411 | 87106 | 111241 | 53150308 |
| Hand deformity | 102.95 | 9.94 | 10 | 87507 | 84839 | 53176710 |
| Glossodynia | 102.50 | 9.94 | 20 | 87497 | 100271 | 53161278 |
| Lower respiratory tract infection | 99.89 | 9.94 | 15 | 87502 | 90966 | 53170583 |
| Renal failure | 97.56 | 9.94 | 419 | 87098 | 118033 | 53143516 |
| Pain | 92.74 | 9.94 | 576 | 86941 | 587822 | 52673727 |
| Drug intolerance | 89.35 | 9.94 | 124 | 87393 | 205369 | 53056180 |
| Dyspnoea | 88.55 | 9.94 | 1400 | 86117 | 584832 | 52676717 |
| Syncope | 86.78 | 9.94 | 389 | 87128 | 111604 | 53149945 |
| Therapeutic product effect decreased | 84.04 | 9.94 | 51 | 87466 | 125604 | 53135945 |
| Oedema peripheral | 82.71 | 9.94 | 521 | 86996 | 170266 | 53091283 |
| Cardiac disorder | 80.75 | 9.94 | 213 | 87304 | 46753 | 53214796 |
| Cerebrovascular accident | 79.75 | 9.94 | 363 | 87154 | 104811 | 53156738 |
| Arthropathy | 79.51 | 9.94 | 69 | 87448 | 141384 | 53120165 |
| International normalised ratio increased | 79.48 | 9.94 | 214 | 87303 | 47547 | 53214002 |
| Arthralgia | 79.18 | 9.94 | 412 | 87105 | 439371 | 52822178 |
| Renal impairment | 76.66 | 9.94 | 305 | 87212 | 83013 | 53178536 |
| Death | 75.78 | 9.94 | 907 | 86610 | 356325 | 52905224 |
| Off label use | 72.88 | 9.94 | 465 | 87052 | 471747 | 52789802 |
| Hepatic enzyme increased | 72.83 | 9.94 | 60 | 87457 | 126135 | 53135414 |
| Pericarditis | 72.13 | 9.94 | 10 | 87507 | 64396 | 53197153 |
| Musculoskeletal stiffness | 72.02 | 9.94 | 58 | 87459 | 123310 | 53138239 |
| Hypoglycaemia | 71.22 | 9.94 | 236 | 87281 | 58777 | 53202772 |
| Hypersensitivity | 70.62 | 9.94 | 150 | 87367 | 210515 | 53051034 |
| Chest pain | 69.64 | 9.94 | 542 | 86975 | 189643 | 53071906 |
| Alopecia | 67.54 | 9.94 | 181 | 87336 | 234402 | 53027147 |
| Wound | 64.29 | 9.94 | 35 | 87482 | 91522 | 53170027 |
| Pulmonary oedema | 64.07 | 9.94 | 214 | 87303 | 53509 | 53208040 |
| Rash | 63.50 | 9.94 | 450 | 87067 | 445741 | 52815808 |
| Hypertensive crisis | 63.13 | 9.94 | 97 | 87420 | 14409 | 53247140 |
| Exposure during pregnancy | 61.95 | 9.94 | 68 | 87449 | 124792 | 53136757 |
| Anaemia | 61.90 | 9.94 | 710 | 86807 | 276008 | 52985541 |
| Atrioventricular block | 58.12 | 9.94 | 65 | 87452 | 7075 | 53254474 |
| Mental status changes | 55.78 | 9.94 | 167 | 87350 | 39404 | 53222145 |
| Blood glucose increased | 55.66 | 9.94 | 263 | 87254 | 77098 | 53184451 |
| Congestive cardiomyopathy | 55.40 | 9.94 | 59 | 87458 | 6079 | 53255470 |
| Dehydration | 54.63 | 9.94 | 467 | 87050 | 167943 | 53093606 |
| Cardiomegaly | 53.57 | 9.94 | 101 | 87416 | 17699 | 53243850 |
| Fluid retention | 52.33 | 9.94 | 202 | 87315 | 54199 | 53207350 |
| Cardiac failure chronic | 51.81 | 9.94 | 47 | 87470 | 3983 | 53257566 |
| Cardioactive drug level increased | 51.48 | 9.94 | 36 | 87481 | 2093 | 53259456 |
| Cardiogenic shock | 51.13 | 9.94 | 98 | 87419 | 17384 | 53244165 |
| Blood creatinine increased | 50.96 | 9.94 | 269 | 87248 | 82393 | 53179156 |
| Full blood count decreased | 50.84 | 9.94 | 118 | 87399 | 23911 | 53237638 |
| Discomfort | 49.59 | 9.94 | 50 | 87467 | 95422 | 53166127 |
| Cardiac arrest | 47.96 | 9.94 | 290 | 87227 | 93377 | 53168172 |
| Blood pressure decreased | 47.96 | 9.94 | 215 | 87302 | 61654 | 53199895 |
| Haemoglobin decreased | 46.77 | 9.94 | 385 | 87132 | 136922 | 53124627 |
| Drug hypersensitivity | 46.22 | 9.94 | 251 | 87266 | 264991 | 52996558 |
| Abortion spontaneous | 46.18 | 9.94 | 10 | 87507 | 46625 | 53214924 |
| Dizziness | 46.16 | 9.94 | 862 | 86655 | 371397 | 52890152 |
| Helicobacter infection | 43.90 | 9.94 | 6 | 87511 | 39063 | 53222486 |
| Impaired healing | 42.99 | 9.94 | 26 | 87491 | 64179 | 53197370 |
| Gastrointestinal tract mucosal pigmentation | 42.97 | 9.94 | 21 | 87496 | 619 | 53260930 |
| Blood loss anaemia | 42.68 | 9.94 | 62 | 87455 | 8761 | 53252788 |
| Pyrexia | 41.94 | 9.94 | 441 | 87076 | 402752 | 52858797 |
| Drug abuse | 41.86 | 9.94 | 28 | 87489 | 65498 | 53196051 |
| Glomerular filtration rate decreased | 41.63 | 9.94 | 75 | 87442 | 12692 | 53248857 |
| Unresponsive to stimuli | 41.50 | 9.94 | 135 | 87382 | 33291 | 53228258 |
| Ischaemic cardiomyopathy | 40.76 | 9.94 | 34 | 87483 | 2574 | 53258975 |
| Folliculitis | 40.47 | 9.94 | 3 | 87514 | 31706 | 53229843 |
| Abdominal discomfort | 39.72 | 9.94 | 207 | 87310 | 220855 | 53040694 |
| Infection | 39.58 | 9.94 | 147 | 87370 | 172058 | 53089491 |
| Injection site pain | 39.43 | 9.94 | 79 | 87438 | 113312 | 53148237 |
| Drug interaction | 39.24 | 9.94 | 540 | 86977 | 218789 | 53042760 |
| Mitral valve incompetence | 39.17 | 9.94 | 94 | 87423 | 19457 | 53242092 |
| Hypertension | 39.11 | 9.94 | 552 | 86965 | 224879 | 53036670 |
| Asthenia | 38.30 | 9.94 | 783 | 86734 | 342807 | 52918742 |
| Coronary arterial stent insertion | 38.10 | 9.94 | 34 | 87483 | 2820 | 53258729 |
| Arrhythmia | 37.38 | 9.94 | 139 | 87378 | 36640 | 53224909 |
| Pregnancy | 37.36 | 9.94 | 4 | 87513 | 31437 | 53230112 |
| Cardiac failure acute | 37.06 | 9.94 | 59 | 87458 | 9033 | 53252516 |
| Fluid overload | 36.92 | 9.94 | 115 | 87402 | 27716 | 53233833 |
| Sinus bradycardia | 36.88 | 9.94 | 77 | 87440 | 14524 | 53247025 |
| Spinal epidural haematoma | 36.65 | 9.94 | 21 | 87496 | 860 | 53260689 |
| Febrile neutropenia | 36.58 | 9.94 | 73 | 87444 | 104863 | 53156686 |
| Renal disorder | 36.46 | 9.94 | 118 | 87399 | 29021 | 53232528 |
| Ventricular arrhythmia | 36.29 | 9.94 | 37 | 87480 | 3623 | 53257926 |
| Product use issue | 35.55 | 9.94 | 114 | 87403 | 139470 | 53122079 |
| End stage renal disease | 35.29 | 9.94 | 47 | 87470 | 6124 | 53255425 |
| Myocardial ischaemia | 35.13 | 9.94 | 70 | 87447 | 12774 | 53248775 |
| Glycosylated haemoglobin increased | 34.90 | 9.94 | 66 | 87451 | 11589 | 53249960 |
| Angina pectoris | 33.86 | 9.94 | 114 | 87403 | 28611 | 53232938 |
| Blood potassium increased | 33.85 | 9.94 | 84 | 87433 | 17757 | 53243792 |
| Distributive shock | 33.23 | 9.94 | 20 | 87497 | 898 | 53260651 |
| Atrioventricular block first degree | 33.19 | 9.94 | 47 | 87470 | 6488 | 53255061 |
| Orthopnoea | 32.64 | 9.94 | 45 | 87472 | 6059 | 53255490 |
| Isosthenuria | 32.51 | 9.94 | 11 | 87506 | 120 | 53261429 |
| Extradural haematoma | 32.26 | 9.94 | 25 | 87492 | 1703 | 53259846 |
| Therapeutic product effect incomplete | 31.86 | 9.94 | 64 | 87453 | 91720 | 53169829 |
| Calcium deficiency | 31.75 | 9.94 | 20 | 87497 | 975 | 53260574 |
| Swelling | 31.55 | 9.94 | 184 | 87333 | 190921 | 53070628 |
| Pericardial effusion | 31.05 | 9.94 | 107 | 87410 | 27171 | 53234378 |
| Asthma | 29.89 | 9.94 | 86 | 87431 | 108886 | 53152663 |
| Pulse absent | 29.71 | 9.94 | 40 | 87477 | 5266 | 53256283 |
| Left ventricular dysfunction | 29.25 | 9.94 | 60 | 87457 | 11177 | 53250372 |
| Myxoedema coma | 28.29 | 9.94 | 14 | 87503 | 424 | 53261125 |
| Sinusitis | 27.44 | 9.94 | 163 | 87354 | 168401 | 53093148 |
| Coronary artery occlusion | 27.43 | 9.94 | 49 | 87468 | 8238 | 53253311 |
| Ventricular hypokinesia | 27.40 | 9.94 | 35 | 87482 | 4377 | 53257172 |
| Angina unstable | 27.12 | 9.94 | 46 | 87471 | 7422 | 53254127 |
| Pyelitis | 26.85 | 9.94 | 11 | 87506 | 211 | 53261338 |
| Bladder hypertrophy | 26.25 | 9.94 | 11 | 87506 | 224 | 53261325 |
| Erythema | 25.97 | 9.94 | 151 | 87366 | 156818 | 53104731 |
| Injection site erythema | 25.85 | 9.94 | 55 | 87462 | 77194 | 53184355 |
| Fall | 25.83 | 9.94 | 770 | 86747 | 357670 | 52903879 |
| Suicidal ideation | 25.77 | 9.94 | 37 | 87480 | 60474 | 53201075 |
| Left ventricular hypertrophy | 25.70 | 9.94 | 37 | 87480 | 5186 | 53256363 |
| Dialysis | 25.49 | 9.94 | 54 | 87463 | 10288 | 53251261 |
| Vessel puncture site haemorrhage | 25.45 | 9.94 | 9 | 87508 | 113 | 53261436 |
| Electrocardiogram PR shortened | 25.42 | 9.94 | 11 | 87506 | 243 | 53261306 |
| Ventricular tachycardia | 25.06 | 9.94 | 75 | 87442 | 17687 | 53243862 |
| Blood urea increased | 24.89 | 9.94 | 97 | 87420 | 26134 | 53235415 |
| Nasopharyngitis | 24.85 | 9.94 | 199 | 87318 | 192096 | 53069453 |
| Sleep disorder due to general medical condition, insomnia type | 24.56 | 9.94 | 5 | 87512 | 24344 | 53237205 |
| Blood pressure inadequately controlled | 24.47 | 9.94 | 35 | 87482 | 4876 | 53256673 |
| Blood glucose decreased | 24.09 | 9.94 | 80 | 87437 | 19936 | 53241613 |
| Blister | 23.98 | 9.94 | 59 | 87458 | 78694 | 53182855 |
| Gastrointestinal disorder | 23.97 | 9.94 | 72 | 87445 | 89932 | 53171617 |
| Diastolic dysfunction | 23.93 | 9.94 | 38 | 87479 | 5806 | 53255743 |
| Irritable bowel syndrome | 23.64 | 9.94 | 22 | 87495 | 43610 | 53217939 |
| Ill-defined disorder | 23.35 | 9.94 | 28 | 87489 | 49416 | 53212133 |
| Implantable defibrillator insertion | 23.31 | 9.94 | 12 | 87505 | 396 | 53261153 |
| Melaena | 23.14 | 9.94 | 102 | 87415 | 29027 | 53232522 |
| Migraine | 23.14 | 9.94 | 62 | 87455 | 80355 | 53181194 |
| Stomatitis | 23.05 | 9.94 | 83 | 87434 | 98075 | 53163474 |
| Acute respiratory failure | 23.00 | 9.94 | 107 | 87410 | 31151 | 53230398 |
| Respiratory failure | 22.89 | 9.94 | 259 | 87258 | 100253 | 53161296 |
| Arterial stenosis | 22.76 | 9.94 | 14 | 87503 | 654 | 53260895 |
| Peritonitis bacterial | 22.71 | 9.94 | 49 | 87468 | 9456 | 53252093 |
| Intracardiac thrombus | 22.59 | 9.94 | 24 | 87493 | 2465 | 53259084 |
| Tricuspid valve incompetence | 22.44 | 9.94 | 63 | 87454 | 14333 | 53247216 |
| Red blood cell sedimentation rate increased | 22.35 | 9.94 | 9 | 87508 | 28048 | 53233501 |
| Upper gastrointestinal haemorrhage | 22.18 | 9.94 | 71 | 87446 | 17359 | 53244190 |
| Blood pressure abnormal | 22.00 | 9.94 | 60 | 87457 | 13423 | 53248126 |
| Ischaemic stroke | 21.73 | 9.94 | 72 | 87445 | 17921 | 53243628 |
| Brain natriuretic peptide increased | 21.52 | 9.94 | 33 | 87484 | 4892 | 53256657 |
| Haemorrhage intracranial | 21.37 | 9.94 | 59 | 87458 | 13293 | 53248256 |
| Atrial flutter | 21.28 | 9.94 | 48 | 87469 | 9543 | 53252006 |
| Urticaria | 21.27 | 9.94 | 133 | 87384 | 135752 | 53125797 |
| Blood pressure increased | 21.21 | 9.94 | 336 | 87181 | 140143 | 53121406 |
| Subdural haematoma | 21.09 | 9.94 | 60 | 87457 | 13753 | 53247796 |
| Injection site reaction | 21.09 | 9.94 | 32 | 87485 | 51134 | 53210415 |
| Aortic valve incompetence | 20.94 | 9.94 | 37 | 87480 | 6168 | 53255381 |
| Hypovolaemia | 20.82 | 9.94 | 50 | 87467 | 10352 | 53251197 |
| Foetal exposure during pregnancy | 20.65 | 9.94 | 16 | 87501 | 34699 | 53226850 |
| Condition aggravated | 20.31 | 9.94 | 354 | 87163 | 296780 | 52964769 |
| Leukopenia | 20.12 | 9.94 | 58 | 87459 | 73405 | 53188144 |
| Neutropenia | 19.98 | 9.94 | 166 | 87351 | 159019 | 53102530 |
| Loss of consciousness | 19.90 | 9.94 | 280 | 87237 | 113932 | 53147617 |
| Headache | 19.90 | 9.94 | 701 | 86816 | 536120 | 52725429 |
| Cerebral infarction | 19.73 | 9.94 | 86 | 87431 | 24358 | 53237191 |
| Completed suicide | 19.54 | 9.94 | 327 | 87190 | 137874 | 53123675 |
| Pneumonia | 19.50 | 9.94 | 835 | 86682 | 406334 | 52855215 |
| Decreased appetite | 19.21 | 9.94 | 475 | 87042 | 214499 | 53047050 |
| Pleural effusion | 19.16 | 9.94 | 226 | 87291 | 88353 | 53173196 |
| Chronic obstructive pulmonary disease | 19.06 | 9.94 | 168 | 87349 | 60905 | 53200644 |
| Platelet dysfunction | 18.98 | 9.94 | 7 | 87510 | 100 | 53261449 |
| Arteriosclerosis | 18.55 | 9.94 | 47 | 87470 | 10064 | 53251485 |
| Urinary tract infection | 18.52 | 9.94 | 520 | 86997 | 239383 | 53022166 |
| Basal ganglia haemorrhage | 18.48 | 9.94 | 12 | 87505 | 617 | 53260932 |
| Lower gastrointestinal haemorrhage | 18.07 | 9.94 | 39 | 87478 | 7527 | 53254022 |
| Hypervolaemia | 18.06 | 9.94 | 20 | 87497 | 2153 | 53259396 |
| Hip arthroplasty | 17.67 | 9.94 | 12 | 87505 | 27850 | 53233699 |
| Atrioventricular block complete | 17.66 | 9.94 | 40 | 87477 | 7975 | 53253574 |
| Electrocardiogram QT shortened | 17.65 | 9.94 | 7 | 87510 | 123 | 53261426 |
| Oropharyngeal pain | 17.61 | 9.94 | 71 | 87446 | 81197 | 53180352 |
| Medication error | 17.60 | 9.94 | 111 | 87406 | 36254 | 53225295 |
| Device expulsion | 17.40 | 9.94 | 14 | 87503 | 29799 | 53231750 |
| Pulseless electrical activity | 17.32 | 9.94 | 38 | 87479 | 7416 | 53254133 |
| Mucocutaneous haemorrhage | 17.29 | 9.94 | 6 | 87511 | 71 | 53261478 |
| Renal hypoplasia | 17.25 | 9.94 | 5 | 87512 | 31 | 53261518 |
| Femoral artery dissection | 17.25 | 9.94 | 5 | 87512 | 31 | 53261518 |
| Pulmonary congestion | 17.20 | 9.94 | 62 | 87455 | 16094 | 53245455 |
| Gout | 17.16 | 9.94 | 52 | 87465 | 12347 | 53249202 |
| Peripheral coldness | 17.07 | 9.94 | 48 | 87469 | 10931 | 53250618 |
| Genotype drug resistance test positive | 16.81 | 9.94 | 11 | 87506 | 573 | 53260976 |
| Left ventricular dilatation | 16.68 | 9.94 | 10 | 87507 | 446 | 53261103 |
| Nephropathy | 16.62 | 9.94 | 31 | 87486 | 5386 | 53256163 |
| Hydrothorax | 16.55 | 9.94 | 12 | 87505 | 739 | 53260810 |
| Hypertensive emergency | 16.35 | 9.94 | 17 | 87500 | 1704 | 53259845 |
| Mobility decreased | 16.29 | 9.94 | 67 | 87450 | 76204 | 53185345 |
| Vena cava injury | 16.24 | 9.94 | 3 | 87514 | 0 | 53261549 |
| Electrocardiogram ST segment | 16.24 | 9.94 | 3 | 87514 | 0 | 53261549 |
| Nephrogenic anaemia | 16.23 | 9.94 | 18 | 87499 | 1941 | 53259608 |
| Urine albumin/creatinine ratio increased | 16.21 | 9.94 | 8 | 87509 | 241 | 53261308 |
| Tendonitis | 16.13 | 9.94 | 4 | 87513 | 17002 | 53244547 |
| Electrocardiogram abnormal | 16.12 | 9.94 | 39 | 87478 | 8114 | 53253435 |
| Renal injury | 16.09 | 9.94 | 44 | 87473 | 9860 | 53251689 |
| Creatinine renal clearance increased | 16.02 | 9.94 | 11 | 87506 | 621 | 53260928 |
| Coronary artery bypass | 15.93 | 9.94 | 20 | 87497 | 2458 | 53259091 |
| Hypouricaemia | 15.92 | 9.94 | 7 | 87510 | 161 | 53261388 |
| Therapy cessation | 15.78 | 9.94 | 89 | 87428 | 27936 | 53233613 |
| Shock | 15.43 | 9.94 | 77 | 87440 | 23062 | 53238487 |
| Injection site swelling | 15.41 | 9.94 | 29 | 87488 | 42599 | 53218950 |
| Cardiac operation | 15.21 | 9.94 | 21 | 87496 | 2832 | 53258717 |
| Toxic neuropathy | 15.16 | 9.94 | 9 | 87508 | 394 | 53261155 |
| Renal artery stenosis | 15.13 | 9.94 | 17 | 87500 | 1859 | 53259690 |
| Haematocrit decreased | 15.10 | 9.94 | 109 | 87408 | 37222 | 53224327 |
| Plasma cell myeloma | 15.09 | 9.94 | 132 | 87385 | 47742 | 53213807 |
| Hypertensive encephalopathy | 15.09 | 9.94 | 11 | 87506 | 683 | 53260866 |
| Vascular stent stenosis | 14.89 | 9.94 | 10 | 87507 | 544 | 53261005 |
| Psoriatic arthropathy | 14.75 | 9.94 | 36 | 87481 | 48154 | 53213395 |
| Pernicious anaemia | 14.66 | 9.94 | 11 | 87506 | 714 | 53260835 |
| Intentional self-injury | 14.60 | 9.94 | 12 | 87505 | 25272 | 53236277 |
| Embolic stroke | 14.59 | 9.94 | 24 | 87493 | 3775 | 53257774 |
| Cardio-respiratory arrest | 14.57 | 9.94 | 154 | 87363 | 58604 | 53202945 |
| Bundle branch block left | 14.35 | 9.94 | 34 | 87483 | 6979 | 53254570 |
| Unevaluable event | 14.34 | 9.94 | 134 | 87383 | 49364 | 53212185 |
| Subdural haemorrhage | 14.33 | 9.94 | 21 | 87496 | 2991 | 53258558 |
| Transfusion | 14.13 | 9.94 | 52 | 87465 | 13635 | 53247914 |
| Chronic left ventricular failure | 14.04 | 9.94 | 8 | 87509 | 324 | 53261225 |
| Occult blood positive | 13.98 | 9.94 | 23 | 87494 | 3619 | 53257930 |
| Malignant neoplasm progression | 13.97 | 9.94 | 65 | 87452 | 71476 | 53190073 |
| Renal atrophy | 13.67 | 9.94 | 14 | 87503 | 1378 | 53260171 |
| Heart injury | 13.67 | 9.94 | 13 | 87504 | 1170 | 53260379 |
| Metabolic acidosis | 13.59 | 9.94 | 117 | 87400 | 42125 | 53219424 |
| Oral herpes | 13.59 | 9.94 | 9 | 87508 | 21170 | 53240379 |
| Paraplegia | 13.39 | 9.94 | 19 | 87498 | 2628 | 53258921 |
| Supraventricular extrasystoles | 13.28 | 9.94 | 25 | 87492 | 4375 | 53257174 |
| Pulmonary arterial pressure increased | 13.24 | 9.94 | 22 | 87495 | 3490 | 53258059 |
| Product use in unapproved indication | 13.24 | 9.94 | 119 | 87398 | 112170 | 53149379 |
| Insulin-requiring type 2 diabetes mellitus | 13.21 | 9.94 | 5 | 87512 | 77 | 53261472 |
| Arterial occlusive disease | 13.19 | 9.94 | 27 | 87490 | 5022 | 53256527 |
| Herbal interaction | 13.10 | 9.94 | 5 | 87512 | 79 | 53261470 |
| Cytomegalovirus infection | 12.95 | 9.94 | 8 | 87509 | 19531 | 53242018 |
| Lethargy | 12.91 | 9.94 | 140 | 87377 | 53620 | 53207929 |
| Ventricular fibrillation | 12.90 | 9.94 | 46 | 87471 | 11879 | 53249670 |
| Catheterisation cardiac | 12.79 | 9.94 | 24 | 87493 | 4190 | 53257359 |
| Injection site pruritus | 12.78 | 9.94 | 31 | 87486 | 41558 | 53219991 |
| Urine output decreased | 12.71 | 9.94 | 45 | 87472 | 11578 | 53249971 |
| Presyncope | 12.70 | 9.94 | 80 | 87437 | 26114 | 53235435 |
| Drug dependence | 12.64 | 9.94 | 10 | 87507 | 21462 | 53240087 |
| Cognitive disorder | 12.52 | 9.94 | 35 | 87482 | 44743 | 53216806 |
| Basal cell carcinoma | 12.52 | 9.94 | 12 | 87505 | 23457 | 53238092 |
| Diarrhoea | 12.44 | 9.94 | 1189 | 86328 | 624357 | 52637192 |
| Renal tubular injury | 12.43 | 9.94 | 8 | 87509 | 405 | 53261144 |
| Gastritis erosive | 12.37 | 9.94 | 28 | 87489 | 5578 | 53255971 |
| Hyperglycaemia | 12.37 | 9.94 | 110 | 87407 | 39974 | 53221575 |
| Bradyarrhythmia | 12.36 | 9.94 | 16 | 87501 | 2027 | 53259522 |
| Inflammation | 12.32 | 9.94 | 50 | 87467 | 57086 | 53204463 |
| Muscle spasticity | 12.25 | 9.94 | 7 | 87510 | 17831 | 53243718 |
| Bone marrow failure | 12.25 | 9.94 | 19 | 87498 | 30096 | 53231453 |
| Loss of personal independence in daily activities | 12.17 | 9.94 | 66 | 87451 | 69749 | 53191800 |
| Body temperature increased | 12.14 | 9.94 | 22 | 87495 | 32777 | 53228772 |
| Subarachnoid haemorrhage | 12.12 | 9.94 | 45 | 87472 | 11848 | 53249701 |
| Traumatic renal injury | 12.10 | 9.94 | 3 | 87514 | 9 | 53261540 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 12.08 | 9.94 | 17 | 87500 | 2334 | 53259215 |
| Renin increased | 12.03 | 9.94 | 6 | 87511 | 185 | 53261364 |
| Gastrointestinal arteriovenous malformation | 11.98 | 9.94 | 9 | 87508 | 585 | 53260964 |
| C-reactive protein increased | 11.93 | 9.94 | 64 | 87453 | 67822 | 53193727 |
| Hospitalisation | 11.93 | 9.94 | 173 | 87344 | 70839 | 53190710 |
| Refractory anaemia with an excess of blasts | 11.92 | 9.94 | 8 | 87509 | 435 | 53261114 |
| Peripheral vascular disorder | 11.84 | 9.94 | 29 | 87488 | 6079 | 53255470 |
| Cardiac pacemaker insertion | 11.83 | 9.94 | 22 | 87495 | 3815 | 53257734 |
| Foot deformity | 11.77 | 9.94 | 8 | 87509 | 18560 | 53242989 |
| Breast cancer recurrent | 11.75 | 9.94 | 23 | 87494 | 4142 | 53257407 |
| Blood aldosterone abnormal | 11.71 | 9.94 | 4 | 87513 | 45 | 53261504 |
| Carbohydrate antigen 15-3 increased | 11.69 | 9.94 | 12 | 87505 | 1184 | 53260365 |
| N-terminal prohormone brain natriuretic peptide increased | 11.66 | 9.94 | 15 | 87502 | 1889 | 53259660 |
| Azotaemia | 11.63 | 9.94 | 24 | 87493 | 4489 | 53257060 |
| Extrapyramidal disorder | 11.60 | 9.94 | 3 | 87514 | 12399 | 53249150 |
| Long QT syndrome | 11.57 | 9.94 | 20 | 87497 | 3276 | 53258273 |
| Premature labour | 11.55 | 9.94 | 3 | 87514 | 12359 | 53249190 |
| Cholestatic liver injury | 11.53 | 9.94 | 17 | 87500 | 2434 | 53259115 |
| Torsade de pointes | 11.46 | 9.94 | 47 | 87470 | 12958 | 53248591 |
| Intercepted product dispensing error | 11.45 | 9.94 | 5 | 87512 | 113 | 53261436 |
| Aortic stenosis | 11.45 | 9.94 | 24 | 87493 | 4539 | 53257010 |
| Bursitis | 11.42 | 9.94 | 12 | 87505 | 22480 | 53239069 |
| Electrocardiogram QRS complex shortened | 11.40 | 9.94 | 8 | 87509 | 468 | 53261081 |
| Electrocardiogram T wave inversion | 11.39 | 9.94 | 21 | 87496 | 3618 | 53257931 |
| Glomerulonephritis rapidly progressive | 11.35 | 9.94 | 10 | 87507 | 815 | 53260734 |
| Hypovolaemic shock | 11.31 | 9.94 | 27 | 87490 | 5570 | 53255979 |
| Palpitations | 11.27 | 9.94 | 233 | 87284 | 102115 | 53159434 |
| Aortic dissection | 11.25 | 9.94 | 14 | 87503 | 1706 | 53259843 |
| Multiple sclerosis relapse | 11.15 | 9.94 | 37 | 87480 | 44816 | 53216733 |
| Arteriovenous fistula thrombosis | 11.10 | 9.94 | 6 | 87511 | 219 | 53261330 |
| Diarrhoea infectious | 11.08 | 9.94 | 11 | 87506 | 1043 | 53260506 |
| Epinephrine increased | 11.06 | 9.94 | 3 | 87514 | 14 | 53261535 |
| Hypophagia | 11.05 | 9.94 | 88 | 87429 | 30974 | 53230575 |
| Vascular pseudoaneurysm | 11.00 | 9.94 | 13 | 87504 | 1501 | 53260048 |
| Atrial tachycardia | 10.98 | 9.94 | 16 | 87501 | 2268 | 53259281 |
| Haematuria | 10.97 | 9.94 | 82 | 87435 | 28307 | 53233242 |
| Breath sounds | 10.95 | 9.94 | 5 | 87512 | 126 | 53261423 |
| Ischaemia | 10.94 | 9.94 | 24 | 87493 | 4684 | 53256865 |
| Blood blister | 10.92 | 9.94 | 14 | 87503 | 1757 | 53259792 |
| Left ventricular enlargement | 10.92 | 9.94 | 4 | 87513 | 56 | 53261493 |
| Phaeochromocytoma crisis | 10.81 | 9.94 | 6 | 87511 | 231 | 53261318 |
| Carcinoembryonic antigen increased | 10.71 | 9.94 | 13 | 87504 | 1544 | 53260005 |
| Premature baby | 10.70 | 9.94 | 10 | 87507 | 19791 | 53241758 |
| Fibromyalgia | 10.52 | 9.94 | 37 | 87480 | 44038 | 53217511 |
| Sinus arrest | 10.48 | 9.94 | 14 | 87503 | 1830 | 53259719 |
| Oral cavity fistula | 10.47 | 9.94 | 9 | 87508 | 710 | 53260839 |
| Cardiac murmur | 10.46 | 9.94 | 43 | 87474 | 11870 | 53249679 |
| Agitation | 10.45 | 9.94 | 55 | 87462 | 58571 | 53202978 |
| Hepatic vein dilatation | 10.44 | 9.94 | 3 | 87514 | 18 | 53261531 |
| Abdominal pain | 10.42 | 9.94 | 330 | 87187 | 255573 | 53005976 |
| Obstructive airways disorder | 10.41 | 9.94 | 8 | 87509 | 17421 | 53244128 |
| Post procedural hypothyroidism | 10.34 | 9.94 | 5 | 87512 | 144 | 53261405 |
| Photophobia | 10.31 | 9.94 | 7 | 87510 | 16251 | 53245298 |
| Angioedema | 10.30 | 9.94 | 110 | 87407 | 41966 | 53219583 |
| Quadriplegia | 10.28 | 9.94 | 14 | 87503 | 1864 | 53259685 |
| Anaphylactic reaction | 10.24 | 9.94 | 55 | 87462 | 58271 | 53203278 |
| Retinopathy hypertensive | 10.21 | 9.94 | 6 | 87511 | 258 | 53261291 |
| Heart rate decreased | 10.19 | 9.94 | 99 | 87418 | 36848 | 53224701 |
| Thrombosis | 10.17 | 9.94 | 148 | 87369 | 60645 | 53200904 |
| Fear | 10.14 | 9.94 | 54 | 87463 | 16587 | 53244962 |
| Injection site urticaria | 10.11 | 9.94 | 4 | 87513 | 12603 | 53248946 |
| Arthritis | 10.08 | 9.94 | 93 | 87424 | 87205 | 53174344 |
| Ventricular extrasystoles | 10.04 | 9.94 | 42 | 87475 | 11682 | 53249867 |
| Hip fracture | 10.02 | 9.94 | 80 | 87437 | 28177 | 53233372 |
| Sudden cardiac death | 9.96 | 9.94 | 15 | 87502 | 2189 | 53259360 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cardiac failure congestive | 1142.21 | 10.91 | 1359 | 99394 | 83493 | 32329280 |
| Cardiac failure | 467.46 | 10.91 | 937 | 99816 | 90736 | 32322037 |
| Myocardial infarction | 385.04 | 10.91 | 1052 | 99701 | 124624 | 32288149 |
| Hypotension | 367.40 | 10.91 | 1481 | 99272 | 214629 | 32198144 |
| Bradycardia | 272.76 | 10.91 | 651 | 100102 | 70911 | 32341862 |
| Ejection fraction decreased | 178.67 | 10.91 | 246 | 100507 | 17412 | 32395361 |
| Coronary artery disease | 156.70 | 10.91 | 421 | 100332 | 49285 | 32363488 |
| Cardiac failure chronic | 138.85 | 10.91 | 140 | 100613 | 7100 | 32405673 |
| Hyperkalaemia | 136.72 | 10.91 | 501 | 100252 | 69249 | 32343524 |
| Acute myocardial infarction | 134.32 | 10.91 | 426 | 100327 | 54723 | 32358050 |
| Syncope | 131.78 | 10.91 | 591 | 100162 | 89533 | 32323240 |
| Ischaemic cardiomyopathy | 124.46 | 10.91 | 125 | 100628 | 6309 | 32406464 |
| Off label use | 120.87 | 10.91 | 514 | 100239 | 305806 | 32106967 |
| Mitral valve incompetence | 118.32 | 10.91 | 185 | 100568 | 14686 | 32398087 |
| Drug abuse | 115.48 | 10.91 | 52 | 100701 | 80191 | 32332582 |
| Dizziness | 112.99 | 10.91 | 1067 | 99686 | 208551 | 32204222 |
| Atrial fibrillation | 109.63 | 10.91 | 677 | 100076 | 116027 | 32296746 |
| Dyspnoea | 105.14 | 10.91 | 1638 | 99115 | 360407 | 32052366 |
| Ventricular tachycardia | 104.31 | 10.91 | 239 | 100514 | 25317 | 32387456 |
| Cardiac failure acute | 103.19 | 10.91 | 142 | 100611 | 10042 | 32402731 |
| Foetal exposure during pregnancy | 97.88 | 10.91 | 8 | 100745 | 41293 | 32371480 |
| Gastrointestinal haemorrhage | 97.19 | 10.91 | 528 | 100225 | 86354 | 32326419 |
| Cardiac disorder | 97.02 | 10.91 | 318 | 100435 | 41548 | 32371225 |
| Pyrexia | 95.00 | 10.91 | 592 | 100161 | 319376 | 32093397 |
| Blood pressure decreased | 91.84 | 10.91 | 357 | 100396 | 50723 | 32362050 |
| Cardiomyopathy | 87.80 | 10.91 | 169 | 100584 | 15844 | 32396929 |
| Neutropenia | 87.75 | 10.91 | 194 | 100559 | 141981 | 32270792 |
| Febrile neutropenia | 81.54 | 10.91 | 154 | 100599 | 119412 | 32293361 |
| International normalised ratio increased | 78.04 | 10.91 | 330 | 100423 | 48705 | 32364068 |
| Drug ineffective | 74.54 | 10.91 | 795 | 99958 | 382682 | 32030091 |
| Rheumatoid arthritis | 73.88 | 10.91 | 23 | 100730 | 44521 | 32368252 |
| Cardiomegaly | 70.62 | 10.91 | 149 | 100604 | 14922 | 32397851 |
| Chronic kidney disease | 65.92 | 10.91 | 272 | 100481 | 39703 | 32373070 |
| Cerebrovascular accident | 61.48 | 10.91 | 468 | 100285 | 85852 | 32326921 |
| Left ventricular dilatation | 58.53 | 10.91 | 33 | 100720 | 678 | 32412095 |
| Pulmonary oedema | 52.23 | 10.91 | 282 | 100471 | 45985 | 32366788 |
| Blood potassium increased | 51.57 | 10.91 | 141 | 100612 | 16663 | 32396110 |
| Completed suicide | 51.19 | 10.91 | 474 | 100279 | 92043 | 32320730 |
| Treatment failure | 50.89 | 10.91 | 29 | 100724 | 39134 | 32373639 |
| Bundle branch block left | 50.34 | 10.91 | 75 | 100678 | 5704 | 32407069 |
| Orthopnoea | 48.65 | 10.91 | 69 | 100684 | 5018 | 32407755 |
| Tricuspid valve incompetence | 47.25 | 10.91 | 95 | 100658 | 9192 | 32403581 |
| Congestive cardiomyopathy | 47.05 | 10.91 | 82 | 100671 | 7120 | 32405653 |
| Angina pectoris | 46.54 | 10.91 | 207 | 100546 | 31219 | 32381554 |
| Blood creatinine increased | 46.09 | 10.91 | 478 | 100275 | 95654 | 32317119 |
| N-terminal prohormone brain natriuretic peptide abnormal | 45.41 | 10.91 | 19 | 100734 | 195 | 32412578 |
| Coronary artery bypass | 44.39 | 10.91 | 66 | 100687 | 5010 | 32407763 |
| Drug reaction with eosinophilia and systemic symptoms | 43.74 | 10.91 | 23 | 100730 | 32462 | 32380311 |
| Renal impairment | 43.47 | 10.91 | 456 | 100297 | 91516 | 32321257 |
| Coronary arterial stent insertion | 42.74 | 10.91 | 59 | 100694 | 4183 | 32408590 |
| Computerised tomogram coronary artery abnormal | 42.21 | 10.91 | 17 | 100736 | 157 | 32412616 |
| Ventricular hypokinesia | 41.84 | 10.91 | 63 | 100690 | 4837 | 32407936 |
| Chest pain | 41.80 | 10.91 | 577 | 100176 | 123560 | 32289213 |
| Heart rate decreased | 41.16 | 10.91 | 171 | 100582 | 25029 | 32387744 |
| Hypoglycaemia | 41.05 | 10.91 | 299 | 100454 | 54083 | 32358690 |
| Suicidal ideation | 40.51 | 10.91 | 35 | 100718 | 38048 | 32374725 |
| Premature baby | 40.20 | 10.91 | 5 | 100748 | 18513 | 32394260 |
| Blood loss anaemia | 39.98 | 10.91 | 81 | 100672 | 7881 | 32404892 |
| Leukopenia | 39.59 | 10.91 | 79 | 100674 | 60043 | 32352730 |
| Fluid retention | 38.64 | 10.91 | 174 | 100579 | 26376 | 32386397 |
| Cardiac arrest | 38.55 | 10.91 | 464 | 100289 | 96312 | 32316461 |
| Toxicity to various agents | 38.20 | 10.91 | 360 | 100393 | 177681 | 32235092 |
| Product use in unapproved indication | 37.59 | 10.91 | 141 | 100612 | 87063 | 32325710 |
| Presyncope | 37.03 | 10.91 | 128 | 100625 | 17173 | 32395600 |
| Agitation | 37.01 | 10.91 | 76 | 100677 | 57160 | 32355613 |
| Acute kidney injury | 36.09 | 10.91 | 1176 | 99577 | 292292 | 32120481 |
| Malignant neoplasm progression | 35.77 | 10.91 | 124 | 100629 | 78372 | 32334401 |
| Sinus bradycardia | 35.25 | 10.91 | 104 | 100649 | 12834 | 32399939 |
| Suicide attempt | 35.10 | 10.91 | 40 | 100713 | 38204 | 32374569 |
| Depression | 35.02 | 10.91 | 168 | 100585 | 96892 | 32315881 |
| Diastolic dysfunction | 34.80 | 10.91 | 60 | 100693 | 5164 | 32407609 |
| Carotid sinus syndrome | 34.54 | 10.91 | 10 | 100743 | 28 | 32412745 |
| Drug dependence | 34.10 | 10.91 | 15 | 100738 | 23469 | 32389304 |
| Atrioventricular block | 33.92 | 10.91 | 74 | 100679 | 7581 | 32405192 |
| Oedema peripheral | 33.54 | 10.91 | 518 | 100235 | 113573 | 32299200 |
| Aggression | 33.20 | 10.91 | 44 | 100709 | 39345 | 32373428 |
| Fractured coccyx | 32.69 | 10.91 | 14 | 100739 | 153 | 32412620 |
| Hepatocellular injury | 32.53 | 10.91 | 19 | 100734 | 25299 | 32387474 |
| Left ventricular dysfunction | 32.43 | 10.91 | 84 | 100669 | 9611 | 32403162 |
| Blood pressure inadequately controlled | 32.27 | 10.91 | 41 | 100712 | 2681 | 32410092 |
| Mucosal inflammation | 31.75 | 10.91 | 34 | 100719 | 33400 | 32379373 |
| Renal failure | 31.32 | 10.91 | 588 | 100165 | 133890 | 32278883 |
| Cardiogenic shock | 31.27 | 10.91 | 137 | 100616 | 20525 | 32392248 |
| Cholestasis | 31.06 | 10.91 | 23 | 100730 | 27010 | 32385763 |
| Asthenia | 30.67 | 10.91 | 952 | 99801 | 234992 | 32177781 |
| Brain natriuretic peptide abnormal | 30.47 | 10.91 | 17 | 100736 | 342 | 32412431 |
| Ventricular internal diameter abnormal | 30.46 | 10.91 | 12 | 100741 | 104 | 32412669 |
| Cardioactive drug level increased | 30.14 | 10.91 | 32 | 100721 | 1724 | 32411049 |
| Arthralgia | 29.79 | 10.91 | 305 | 100448 | 148143 | 32264630 |
| Rales | 29.68 | 10.91 | 71 | 100682 | 7730 | 32405043 |
| Bradyarrhythmia | 29.67 | 10.91 | 35 | 100718 | 2119 | 32410654 |
| N-terminal prohormone brain natriuretic peptide increased | 29.64 | 10.91 | 34 | 100719 | 1998 | 32410775 |
| Mouth breathing | 29.58 | 10.91 | 11 | 100742 | 80 | 32412693 |
| Suspected suicide | 28.85 | 10.91 | 41 | 100712 | 2987 | 32409786 |
| Generalised tonic-clonic seizure | 28.70 | 10.91 | 14 | 100739 | 20625 | 32392148 |
| Nodal rhythm | 28.50 | 10.91 | 29 | 100724 | 1486 | 32411287 |
| Arrhythmia | 27.73 | 10.91 | 196 | 100557 | 35107 | 32377666 |
| Lower respiratory tract infection | 27.47 | 10.91 | 30 | 100723 | 29213 | 32383560 |
| Jugular vein distension | 27.31 | 10.91 | 19 | 100734 | 571 | 32412202 |
| Nodal arrhythmia | 27.24 | 10.91 | 22 | 100731 | 832 | 32411941 |
| Seizure | 27.24 | 10.91 | 199 | 100554 | 103655 | 32309118 |
| Sudden cardiac death | 27.16 | 10.91 | 45 | 100708 | 3749 | 32409024 |
| Alanine aminotransferase increased | 27.06 | 10.91 | 138 | 100615 | 78341 | 32334432 |
| Thrombocytopenia | 26.84 | 10.91 | 312 | 100441 | 147987 | 32264786 |
| Blood thyroid stimulating hormone abnormal | 26.83 | 10.91 | 14 | 100739 | 245 | 32412528 |
| Rash | 26.76 | 10.91 | 472 | 100281 | 208861 | 32203912 |
| Pulmonary arterial pressure abnormal | 26.64 | 10.91 | 13 | 100740 | 196 | 32412577 |
| Therapeutic product effect incomplete | 26.63 | 10.91 | 55 | 100698 | 41286 | 32371487 |
| Sinus arrest | 26.53 | 10.91 | 29 | 100724 | 1615 | 32411158 |
| Electrocardiogram QRS complex abnormal | 26.48 | 10.91 | 15 | 100738 | 311 | 32412462 |
| Blood glucose decreased | 26.29 | 10.91 | 97 | 100656 | 13437 | 32399336 |
| Infusion related reaction | 25.86 | 10.91 | 65 | 100688 | 45534 | 32367239 |
| Pancytopenia | 25.80 | 10.91 | 171 | 100582 | 91064 | 32321709 |
| Agranulocytosis | 25.67 | 10.91 | 21 | 100732 | 23456 | 32389317 |
| Neutrophil count decreased | 25.35 | 10.91 | 69 | 100684 | 47070 | 32365703 |
| Electrocardiogram abnormal | 25.33 | 10.91 | 67 | 100686 | 7763 | 32405010 |
| Rash maculo-papular | 24.97 | 10.91 | 30 | 100723 | 27992 | 32384781 |
| Blood urea increased | 24.66 | 10.91 | 178 | 100575 | 32095 | 32380678 |
| Shock | 24.56 | 10.91 | 143 | 100610 | 23971 | 32388802 |
| Pulmonary hypertension | 24.54 | 10.91 | 127 | 100626 | 20367 | 32392406 |
| Brain natriuretic peptide increased | 24.33 | 10.91 | 46 | 100707 | 4254 | 32408519 |
| Dyspnoea exertional | 24.30 | 10.91 | 205 | 100548 | 38756 | 32374017 |
| Fall | 24.25 | 10.91 | 787 | 99966 | 195414 | 32217359 |
| Orthostatic hypotension | 24.14 | 10.91 | 149 | 100604 | 25501 | 32387272 |
| Cytomegalovirus infection | 24.06 | 10.91 | 26 | 100727 | 25438 | 32387335 |
| Candida infection | 23.98 | 10.91 | 11 | 100742 | 16792 | 32395981 |
| Intentional overdose | 23.82 | 10.91 | 59 | 100694 | 41542 | 32371231 |
| Haemorrhage intracranial | 23.78 | 10.91 | 105 | 100648 | 15782 | 32396991 |
| Ventricular arrhythmia | 23.54 | 10.91 | 50 | 100703 | 5029 | 32407744 |
| Oxygen saturation increased | 23.46 | 10.91 | 13 | 100740 | 258 | 32412515 |
| Drug resistance | 23.35 | 10.91 | 22 | 100731 | 22943 | 32389830 |
| Nonalcoholic fatty liver disease | 23.31 | 10.91 | 14 | 100739 | 325 | 32412448 |
| Coma | 23.20 | 10.91 | 62 | 100691 | 42550 | 32370223 |
| Pericardial disease | 23.12 | 10.91 | 14 | 100739 | 330 | 32412443 |
| Pulmonary valve disease | 22.97 | 10.91 | 13 | 100740 | 269 | 32412504 |
| Oesophageal discomfort | 22.68 | 10.91 | 8 | 100745 | 49 | 32412724 |
| Neuroleptic malignant syndrome | 22.66 | 10.91 | 13 | 100740 | 17482 | 32395291 |
| Blood glucose increased | 22.64 | 10.91 | 305 | 100448 | 64936 | 32347837 |
| Glomerular filtration rate decreased | 22.56 | 10.91 | 89 | 100664 | 12722 | 32400051 |
| Neutrophil count increased | 22.30 | 10.91 | 11 | 100742 | 16103 | 32396670 |
| Sedation | 22.29 | 10.91 | 15 | 100738 | 18511 | 32394262 |
| End stage renal disease | 22.27 | 10.91 | 65 | 100688 | 7972 | 32404801 |
| Hypertensive crisis | 22.25 | 10.91 | 69 | 100684 | 8748 | 32404025 |
| Erythema | 21.90 | 10.91 | 159 | 100594 | 82946 | 32329827 |
| Cerebral infarction | 21.50 | 10.91 | 153 | 100600 | 27461 | 32385312 |
| Musculoskeletal stiffness | 21.47 | 10.91 | 57 | 100696 | 39207 | 32373566 |
| Conjunctival scar | 21.30 | 10.91 | 8 | 100745 | 60 | 32412713 |
| Ventricular fibrillation | 21.24 | 10.91 | 108 | 100645 | 17202 | 32395571 |
| Cardio-respiratory arrest | 21.21 | 10.91 | 266 | 100487 | 55723 | 32357050 |
| Angina unstable | 21.09 | 10.91 | 85 | 100668 | 12270 | 32400503 |
| Fluid overload | 21.06 | 10.91 | 118 | 100635 | 19503 | 32393270 |
| Death | 21.02 | 10.91 | 1414 | 99339 | 381103 | 32031670 |
| Drug withdrawal syndrome | 21.02 | 10.91 | 19 | 100734 | 20212 | 32392561 |
| Graft versus host disease | 20.99 | 10.91 | 4 | 100749 | 10802 | 32401971 |
| Full blood count decreased | 20.78 | 10.91 | 106 | 100647 | 16904 | 32395869 |
| Osteonecrosis | 20.62 | 10.91 | 13 | 100740 | 16609 | 32396164 |
| Epilepsy | 20.42 | 10.91 | 23 | 100730 | 22086 | 32390687 |
| Neutropenic sepsis | 20.27 | 10.91 | 7 | 100746 | 12692 | 32400081 |
| Mitral valve calcification | 20.02 | 10.91 | 16 | 100737 | 596 | 32412177 |
| Bone marrow failure | 19.96 | 10.91 | 40 | 100713 | 30364 | 32382409 |
| C-reactive protein increased | 19.93 | 10.91 | 79 | 100674 | 48023 | 32364750 |
| Serotonin syndrome | 19.81 | 10.91 | 18 | 100735 | 19099 | 32393674 |
| Injection site pain | 19.63 | 10.91 | 46 | 100707 | 33012 | 32379761 |
| Hepatitis | 19.42 | 10.91 | 27 | 100726 | 23666 | 32389107 |
| Type V hyperlipidaemia | 19.31 | 10.91 | 17 | 100736 | 725 | 32412048 |
| Bundle branch block | 19.27 | 10.91 | 19 | 100734 | 937 | 32411836 |
| Lymphadenopathy | 19.21 | 10.91 | 34 | 100719 | 27048 | 32385725 |
| Gingival hypertrophy | 19.21 | 10.91 | 25 | 100728 | 1674 | 32411099 |
| Nephrogenic anaemia | 19.09 | 10.91 | 29 | 100724 | 2244 | 32410529 |
| Intentional product use issue | 19.00 | 10.91 | 67 | 100686 | 42144 | 32370629 |
| Schizophrenia | 18.76 | 10.91 | 4 | 100749 | 9980 | 32402793 |
| Torsade de pointes | 18.69 | 10.91 | 58 | 100695 | 7357 | 32405416 |
| Myocardial ischaemia | 18.53 | 10.91 | 106 | 100647 | 17653 | 32395120 |
| Lymphopenia | 18.36 | 10.91 | 11 | 100742 | 14445 | 32398328 |
| Cardiac pacemaker insertion | 18.27 | 10.91 | 31 | 100722 | 2634 | 32410139 |
| Oedema | 18.19 | 10.91 | 217 | 100536 | 44930 | 32367843 |
| Vomiting | 18.11 | 10.91 | 574 | 100179 | 234983 | 32177790 |
| Abnormal behaviour | 18.09 | 10.91 | 34 | 100719 | 26432 | 32386341 |
| Loss of personal independence in daily activities | 17.88 | 10.91 | 35 | 100718 | 26798 | 32385975 |
| Concomitant disease progression | 17.69 | 10.91 | 30 | 100723 | 2548 | 32410225 |
| Gallbladder oedema | 17.62 | 10.91 | 10 | 100743 | 208 | 32412565 |
| Immune reconstitution inflammatory syndrome | 17.62 | 10.91 | 4 | 100749 | 9555 | 32403218 |
| Ejection fraction abnormal | 17.58 | 10.91 | 18 | 100735 | 929 | 32411844 |
| Conduction disorder | 17.58 | 10.91 | 26 | 100727 | 1964 | 32410809 |
| Progressive multifocal leukoencephalopathy | 17.54 | 10.91 | 4 | 100749 | 9527 | 32403246 |
| Implantable defibrillator insertion | 17.53 | 10.91 | 16 | 100737 | 716 | 32412057 |
| Pathogen resistance | 17.49 | 10.91 | 4 | 100749 | 9506 | 32403267 |
| Aspergillus infection | 17.43 | 10.91 | 7 | 100746 | 11567 | 32401206 |
| Atrioventricular block second degree | 17.34 | 10.91 | 35 | 100718 | 3395 | 32409378 |
| Left atrial dilatation | 17.32 | 10.91 | 25 | 100728 | 1847 | 32410926 |
| Atrioventricular block complete | 17.28 | 10.91 | 64 | 100689 | 8880 | 32403893 |
| Acute pulmonary oedema | 17.20 | 10.91 | 58 | 100695 | 7683 | 32405090 |
| Pulmonary embolism | 17.13 | 10.91 | 171 | 100582 | 83488 | 32329285 |
| Fatigue | 17.10 | 10.91 | 1284 | 99469 | 349417 | 32063356 |
| Intentional self-injury | 17.06 | 10.91 | 11 | 100742 | 13889 | 32398884 |
| Vascular graft | 17.05 | 10.91 | 22 | 100731 | 1461 | 32411312 |
| Pneumocystis jirovecii pneumonia | 17.03 | 10.91 | 20 | 100733 | 18850 | 32393923 |
| Haemophagocytic lymphohistiocytosis | 16.84 | 10.91 | 7 | 100746 | 11328 | 32401445 |
| Upper gastrointestinal haemorrhage | 16.78 | 10.91 | 129 | 100624 | 23720 | 32389053 |
| Hallucination | 16.76 | 10.91 | 95 | 100658 | 52524 | 32360249 |
| Cardiac discomfort | 16.70 | 10.91 | 13 | 100740 | 466 | 32412307 |
| Tremor | 16.69 | 10.91 | 166 | 100587 | 81111 | 32331662 |
| Bronchopulmonary aspergillosis | 16.57 | 10.91 | 11 | 100742 | 13676 | 32399097 |
| Arterial spasm | 16.43 | 10.91 | 8 | 100745 | 120 | 32412653 |
| Psychotic disorder | 16.24 | 10.91 | 29 | 100724 | 22991 | 32389782 |
| Pulmonary renal syndrome | 16.22 | 10.91 | 9 | 100744 | 179 | 32412594 |
| Asthma | 16.04 | 10.91 | 76 | 100677 | 43989 | 32368784 |
| Hypovolaemia | 15.90 | 10.91 | 62 | 100691 | 8815 | 32403958 |
| Urticaria | 15.73 | 10.91 | 114 | 100639 | 59500 | 32353273 |
| Mitral valve thickening | 15.71 | 10.91 | 12 | 100741 | 418 | 32412355 |
| Osteonecrosis of jaw | 15.55 | 10.91 | 22 | 100731 | 19144 | 32393629 |
| Periodontitis | 15.51 | 10.91 | 24 | 100729 | 1887 | 32410886 |
| Respiratory depression | 15.49 | 10.91 | 11 | 100742 | 13200 | 32399573 |
| Drug hypersensitivity | 15.46 | 10.91 | 149 | 100604 | 73251 | 32339522 |
| Ventricular extrasystoles | 15.44 | 10.91 | 76 | 100677 | 11950 | 32400823 |
| Extrapyramidal disorder | 15.18 | 10.91 | 9 | 100744 | 11886 | 32400887 |
| Overdose | 15.04 | 10.91 | 185 | 100568 | 86892 | 32325881 |
| Dizziness postural | 14.86 | 10.91 | 46 | 100707 | 5826 | 32406947 |
| Tumour lysis syndrome | 14.71 | 10.91 | 14 | 100739 | 14533 | 32398240 |
| Subdural haematoma | 14.64 | 10.91 | 109 | 100644 | 19844 | 32392929 |
| Cardioversion | 14.52 | 10.91 | 16 | 100737 | 899 | 32411874 |
| Mitral valve disease | 14.45 | 10.91 | 19 | 100734 | 1285 | 32411488 |
| Pulse waveform abnormal | 14.43 | 10.91 | 4 | 100749 | 9 | 32412764 |
| Colitis ulcerative | 14.41 | 10.91 | 19 | 100734 | 17032 | 32395741 |
| Physical examination abnormal | 14.39 | 10.91 | 9 | 100744 | 225 | 32412548 |
| Arteriosclerosis | 14.35 | 10.91 | 70 | 100683 | 10964 | 32401809 |
| Dyspnoea at rest | 14.35 | 10.91 | 32 | 100721 | 3327 | 32409446 |
| Cardioactive drug level above therapeutic | 14.31 | 10.91 | 6 | 100747 | 62 | 32412711 |
| Intracardiac thrombus | 14.30 | 10.91 | 27 | 100726 | 2494 | 32410279 |
| Pulmonary arterial pressure increased | 14.26 | 10.91 | 18 | 100735 | 1169 | 32411604 |
| Stenosis | 14.23 | 10.91 | 17 | 100736 | 1043 | 32411730 |
| Disturbance in attention | 14.14 | 10.91 | 33 | 100720 | 23720 | 32389053 |
| Gastrointestinal endoscopic therapy | 14.14 | 10.91 | 4 | 100749 | 10 | 32412763 |
| Oral candidiasis | 14.12 | 10.91 | 10 | 100743 | 12017 | 32400756 |
| Mouth ulceration | 14.03 | 10.91 | 9 | 100744 | 11392 | 32401381 |
| Embolic stroke | 13.98 | 10.91 | 34 | 100719 | 3740 | 32409033 |
| Aspartate aminotransferase increased | 13.92 | 10.91 | 135 | 100618 | 66294 | 32346479 |
| Anger | 13.84 | 10.91 | 10 | 100743 | 11894 | 32400879 |
| Infective pulmonary exacerbation of cystic fibrosis | 13.74 | 10.91 | 5 | 100748 | 8774 | 32403999 |
| Tachycardia induced cardiomyopathy | 13.65 | 10.91 | 7 | 100746 | 118 | 32412655 |
| Cerebral haemorrhage | 13.55 | 10.91 | 166 | 100587 | 34581 | 32378192 |
| Shunt occlusion | 13.54 | 10.91 | 14 | 100739 | 731 | 32412042 |
| Gravitational oedema | 13.43 | 10.91 | 13 | 100740 | 627 | 32412146 |
| Toxic skin eruption | 13.19 | 10.91 | 10 | 100743 | 11604 | 32401169 |
| Haematochezia | 13.06 | 10.91 | 182 | 100571 | 39026 | 32373747 |
| Substance abuse | 13.05 | 10.91 | 3 | 100750 | 7104 | 32405669 |
| Epstein-Barr virus infection | 13.00 | 10.91 | 3 | 100750 | 7087 | 32405686 |
| Lower gastrointestinal haemorrhage | 12.99 | 10.91 | 58 | 100695 | 8759 | 32404014 |
| Heart rate abnormal | 12.97 | 10.91 | 21 | 100732 | 1716 | 32411057 |
| Symblepharon | 12.95 | 10.91 | 7 | 100746 | 132 | 32412641 |
| Atrial flutter | 12.93 | 10.91 | 86 | 100667 | 15097 | 32397676 |
| Cardiac output decreased | 12.89 | 10.91 | 15 | 100738 | 895 | 32411878 |
| Azotaemia | 12.60 | 10.91 | 41 | 100712 | 5333 | 32407440 |
| Dyskinesia | 12.35 | 10.91 | 35 | 100718 | 23568 | 32389205 |
| Eosinophilia | 12.34 | 10.91 | 38 | 100715 | 24920 | 32387853 |
| Cerebellar haemorrhage | 12.32 | 10.91 | 19 | 100734 | 1489 | 32411284 |
| Human ehrlichiosis | 12.28 | 10.91 | 8 | 100745 | 215 | 32412558 |
| Coronary artery occlusion | 12.28 | 10.91 | 69 | 100684 | 11416 | 32401357 |
| Headache | 12.12 | 10.91 | 491 | 100262 | 195706 | 32217067 |
| Acute respiratory distress syndrome | 12.10 | 10.91 | 39 | 100714 | 25214 | 32387559 |
| Stomatitis | 12.08 | 10.91 | 74 | 100679 | 40155 | 32372618 |
| Dilatation atrial | 12.08 | 10.91 | 23 | 100730 | 2138 | 32410635 |
| Hypoglycaemic unconsciousness | 12.08 | 10.91 | 14 | 100739 | 832 | 32411941 |
| Blood pressure abnormal | 12.03 | 10.91 | 51 | 100702 | 7529 | 32405244 |
| Miosis | 11.96 | 10.91 | 6 | 100747 | 8698 | 32404075 |
| Supraventricular tachycardia | 11.95 | 10.91 | 66 | 100687 | 10850 | 32401923 |
| Tubulointerstitial nephritis | 11.81 | 10.91 | 27 | 100726 | 19550 | 32393223 |
| Acute generalised exanthematous pustulosis | 11.73 | 10.91 | 3 | 100750 | 6610 | 32406163 |
| Internal haemorrhage | 11.72 | 10.91 | 37 | 100716 | 4735 | 32408038 |
| Delusion | 11.71 | 10.91 | 14 | 100739 | 13094 | 32399679 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 11.66 | 10.91 | 13 | 100740 | 740 | 32412033 |
| Hypertension | 11.57 | 10.91 | 509 | 100244 | 131241 | 32281532 |
| Colitis | 11.52 | 10.91 | 60 | 100693 | 33891 | 32378882 |
| Glycosylated haemoglobin increased | 11.50 | 10.91 | 63 | 100690 | 10326 | 32402447 |
| Sepsis | 11.48 | 10.91 | 390 | 100363 | 158444 | 32254329 |
| Goitre | 11.45 | 10.91 | 19 | 100734 | 1585 | 32411188 |
| Toxic goitre | 11.41 | 10.91 | 3 | 100750 | 5 | 32412768 |
| Large intestinal haemorrhage | 11.41 | 10.91 | 19 | 100734 | 1590 | 32411183 |
| Somnolence | 11.40 | 10.91 | 240 | 100513 | 103557 | 32309216 |
| Confusional state | 11.40 | 10.91 | 347 | 100406 | 142768 | 32270005 |
| Eczema | 11.37 | 10.91 | 18 | 100735 | 14962 | 32397811 |
| Blood pressure systolic decreased | 11.36 | 10.91 | 34 | 100719 | 4229 | 32408544 |
| Hydrothorax | 11.30 | 10.91 | 11 | 100742 | 534 | 32412239 |
| Chills | 11.29 | 10.91 | 172 | 100581 | 77912 | 32334861 |
| Inspiratory capacity decreased | 11.25 | 10.91 | 6 | 100747 | 110 | 32412663 |
| Jaundice | 11.24 | 10.91 | 61 | 100692 | 34097 | 32378676 |
| Injection site swelling | 11.21 | 10.91 | 8 | 100745 | 9576 | 32403197 |
| Procedural hypotension | 11.20 | 10.91 | 15 | 100738 | 1033 | 32411740 |
| Posterior reversible encephalopathy syndrome | 11.19 | 10.91 | 8 | 100745 | 9568 | 32403205 |
| Labile blood pressure | 11.14 | 10.91 | 12 | 100741 | 657 | 32412116 |
| Cholangitis sclerosing | 11.13 | 10.91 | 15 | 100738 | 1039 | 32411734 |
| Multiple organ dysfunction syndrome | 11.10 | 10.91 | 151 | 100602 | 69703 | 32343070 |
| Blood pressure increased | 11.02 | 10.91 | 323 | 100430 | 79031 | 32333742 |
| Hepatitis B | 11.01 | 10.91 | 3 | 100750 | 6338 | 32406435 |
| Atrial septal defect | 10.99 | 10.91 | 4 | 100749 | 7021 | 32405752 |
| Thyroiditis | 10.98 | 10.91 | 21 | 100732 | 1959 | 32410814 |
| Periorbital haemorrhage | 10.97 | 10.91 | 6 | 100747 | 116 | 32412657 |
| Myelosuppression | 10.94 | 10.91 | 12 | 100741 | 11664 | 32401109 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C07AG02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Alpha and beta blocking agents |
| ATC | C07FX06 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations |
| FDA MoA | N0000000099 | Adrenergic alpha-Antagonists |
| FDA MoA | N0000009923 | Adrenergic beta1-Antagonists |
| FDA MoA | N0000009924 | Adrenergic beta2-Antagonists |
| FDA EPC | N0000175553 | alpha-Adrenergic Blocker |
| FDA EPC | N0000175556 | beta-Adrenergic Blocker |
| CHEBI has role | CHEBI:35530 | beta-adrenoceptor antagonists |
| CHEBI has role | CHEBI:35554 | cardiovascular drugs |
| CHEBI has role | CHEBI:35620 | vasodilator |
| CHEBI has role | CHEBI:35674 | antihypertensive |
| CHEBI has role | CHEBI:37890 | alpha-adrenoceptor antagonists |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D058668 | Adrenergic alpha-1 Receptor Antagonists |
| MeSH PA | D000317 | Adrenergic alpha-Antagonists |
| MeSH PA | D018674 | Adrenergic Antagonists |
| MeSH PA | D000319 | Adrenergic beta-Antagonists |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D000975 | Antioxidants |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D014665 | Vasodilator Agents |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Chronic heart failure | indication | 48447003 | |
| Left ventricular cardiac dysfunction | indication | 429589006 | |
| Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
| Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
| Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation | off-label use | ||
| Bronchospasm | contraindication | 4386001 | |
| Complete atrioventricular block | contraindication | 27885002 | |
| Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
| Anaphylaxis | contraindication | 39579001 | |
| Low blood pressure | contraindication | 45007003 | |
| Sinus bradycardia | contraindication | 49710005 | |
| Hepatic failure | contraindication | 59927004 | |
| Chronic bronchitis | contraindication | 63480004 | DOID:6132 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Prinzmetal angina | contraindication | 87343002 | |
| Pulmonary emphysema | contraindication | 87433001 | |
| Cardiogenic shock | contraindication | 89138009 | |
| Second degree atrioventricular block | contraindication | 195042002 | |
| Asthma | contraindication | 195967001 | DOID:2841 |
| Pregnancy, function | contraindication | 289908002 | |
| Peripheral vascular disease | contraindication | 400047006 | |
| Intraoperative floppy iris syndrome | contraindication | 418801006 | |
| Acutely Decompensated HF Requiring Parenteral Inotropic Therapy | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.13 | acidic |
| pKa2 | 7.88 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 10MG | COREG CR | WOODWARD | N022012 | Oct. 20, 2006 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7268156 | June 27, 2023 | TREATMENT OF CONGESTIVE HEART FAILURE |
| 10MG | COREG CR | WOODWARD | N022012 | Oct. 20, 2006 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7268156 | June 27, 2023 | TREATMENT OF HYPERTENSION |
| 20MG | COREG CR | WOODWARD | N022012 | Oct. 20, 2006 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7268156 | June 27, 2023 | TREATMENT OF CONGESTIVE HEART FAILURE |
| 20MG | COREG CR | WOODWARD | N022012 | Oct. 20, 2006 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7268156 | June 27, 2023 | TREATMENT OF HYPERTENSION |
| 40MG | COREG CR | WOODWARD | N022012 | Oct. 20, 2006 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7268156 | June 27, 2023 | TREATMENT OF CONGESTIVE HEART FAILURE |
| 40MG | COREG CR | WOODWARD | N022012 | Oct. 20, 2006 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7268156 | June 27, 2023 | TREATMENT OF HYPERTENSION |
| 80MG | COREG CR | WOODWARD | N022012 | Oct. 20, 2006 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7268156 | June 27, 2023 | TREATMENT OF CONGESTIVE HEART FAILURE |
| 80MG | COREG CR | WOODWARD | N022012 | Oct. 20, 2006 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7268156 | June 27, 2023 | TREATMENT OF HYPERTENSION |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | GPCR | ANTAGONIST | Ki | 9.90 | IUPHAR | CHEMBL | |||
| Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Ki | 9.50 | IUPHAR | CHEMBL | |||
| D(1A) dopamine receptor | GPCR | Ki | 6.13 | DRUG MATRIX | |||||
| D(2) dopamine receptor | GPCR | Ki | 7.31 | DRUG MATRIX | |||||
| Alpha-2A adrenergic receptor | GPCR | Ki | 7.40 | DRUG MATRIX | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.46 | CHEMBL | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 6.93 | DRUG MATRIX | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Ki | 6.27 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 8.48 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.93 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.82 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 7.22 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 6 | GPCR | Ki | 6.15 | DRUG MATRIX | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 7.37 | DRUG MATRIX | |||||
| D(3) dopamine receptor | GPCR | Ki | 6.71 | DRUG MATRIX | |||||
| Beta-3 adrenergic receptor | GPCR | ANTAGONIST | Ki | 9.40 | IUPHAR | ||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 7.89 | DRUG MATRIX | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 6.17 | DRUG MATRIX | |||||
| Alpha-1D adrenergic receptor | GPCR | ANTAGONIST | Ki | 9.05 | DRUG MATRIX | ||||
| Potassium channel subfamily K member 2 | Ion channel | IC50 | 5.80 | CHEMBL | |||||
| Solute carrier family 22 member 1 | Transporter | IC50 | 5.47 | CHEMBL | |||||
| Potassium channel subfamily K member 10 | Ion channel | IC50 | 5.12 | CHEMBL | |||||
| Solute carrier family 22 member 2 | Transporter | IC50 | 5.12 | CHEMBL | |||||
| Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 4.03 | CHEMBL | |||||
| Toll-like receptor 4 | Membrane receptor | IC50 | 4.49 | CHEMBL | |||||
| Alpha-1A adrenergic receptor | GPCR | ANTAGONIST | Ki | 8.66 | WOMBAT-PK | ||||
| Amyloid beta A4 protein | Unclassified | IC50 | 4.52 | CHEMBL | |||||
| Ryanodine receptor 2 | Ion channel | INHIBITOR | IC50 | 4.80 | IUPHAR | ||||
| 5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.74 | DRUG MATRIX | |||||
| Alpha-1B adrenergic receptor | GPCR | Ki | 8.71 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 1B | GPCR | Ki | 6.23 | DRUG MATRIX | |||||
| Alpha-1A adrenergic receptor | GPCR | IC50 | 8.11 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 8.50 | CHEMBL | |||||
| Beta-1 adrenergic receptor | GPCR | Ki | 9.09 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021041 | VUID |
| N0000148505 | NUI |
| D00255 | KEGG_DRUG |
| 610309-89-2 | SECONDARY_CAS_RN |
| C0054836 | UMLSCUI |
| CHEBI:3441 | CHEBI |
| CVD | PDB_CHEM_ID |
| CHEMBL723 | ChEMBL_ID |
| CHEMBL1201167 | ChEMBL_ID |
| D000077261 | MESH_DESCRIPTOR_UI |
| DB01136 | DRUGBANK_ID |
| 2585 | PUBCHEM_CID |
| 551 | IUPHAR_LIGAND_ID |
| 5333 | INN_ID |
| 0K47UL67F2 | UNII |
| 20352 | RXNORM |
| 119032 | MMSL |
| 22339 | MMSL |
| 265288 | MMSL |
| 4363 | MMSL |
| d03847 | MMSL |
| 004167 | NDDF |
| 011844 | NDDF |
| 108551001 | SNOMEDCT_US |
| 386870007 | SNOMEDCT_US |
| 426471008 | SNOMEDCT_US |
| 4021041 | VANDF |
| 4026028 | VANDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| COREGCR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-3370 | CAPSULE, EXTENDED RELEASE | 10 mg | ORAL | NDA | 26 sections |
| COREGCR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-3371 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | NDA | 26 sections |
| COREGCR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-3372 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | NDA | 26 sections |
| COREGCR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-3373 | CAPSULE, EXTENDED RELEASE | 80 mg | ORAL | NDA | 26 sections |
| COREGCR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-3383 | CAPSULE, EXTENDED RELEASE | 10 mg | ORAL | NDA | 26 sections |
| COREGCR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-3385 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | NDA | 26 sections |
| COREGCR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-3387 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | NDA | 26 sections |
| COREGCR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-3388 | CAPSULE, EXTENDED RELEASE | 80 mg | ORAL | NDA | 26 sections |
| COREG | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-4139 | TABLET, FILM COATED | 3.13 mg | ORAL | NDA | 26 sections |
| COREG | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-4140 | TABLET, FILM COATED | 6.25 mg | ORAL | NDA | 26 sections |
| COREG | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-4141 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 26 sections |
| COREG | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0007-4142 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0051 | TABLET, FILM COATED | 3.13 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0135 | TABLET, FILM COATED | 6.25 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7295 | TABLET, FILM COATED | 12.50 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7296 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3631 | TABLET, FILM COATED | 3.13 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3632 | TABLET, FILM COATED | 6.25 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3633 | TABLET, FILM COATED | 12.50 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3634 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7944 | TABLET, FILM COATED | 3.13 mg | ORAL | ANDA | 27 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7945 | TABLET, FILM COATED | 12.50 mg | ORAL | ANDA | 27 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7946 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 27 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8018 | TABLET, FILM COATED | 6.25 mg | ORAL | ANDA | 27 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8387 | TABLET, FILM COATED | 3.13 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8388 | TABLET, FILM COATED | 6.25 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8389 | TABLET, FILM COATED | 12.50 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8390 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 26 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5221 | TABLET, FILM COATED | 3.13 mg | ORAL | ANDA | 25 sections |
| Carvedilol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5222 | TABLET, FILM COATED | 6.25 mg | ORAL | ANDA | 25 sections |