carvedilol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
vasodilators	522	72956-09-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: carvedilol carvedilol phosphate carvediol carvedilol hydrochloride carvedilol HCl BM 14,190	A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION. Molecular weight: 406.48 Formula: C24H26N2O4 CLOGP: 4.04 LIPINSKI: 0 HAC: 6 HDO: 3 TPSA: 75.74 ALOGS: -4.96 ROTB: 10 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

carvedilol
carvedilol phosphate
carvediol
carvedilol hydrochloride
carvedilol HCl
BM 14,190

A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.

Molecular weight: 406.48
Formula: C24H26N2O4
CLOGP: 4.04
LIPINSKI: 0
HAC: 6
HDO: 3
TPSA: 75.74
ALOGS: -4.96
ROTB: 10

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
37.50	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.01 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.03 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	1.30 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	7.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	2.40 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Sept. 14, 1995	FDA	SMITHKLINE BEECHAM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	863.62	33.20	231	1543	20803	2335508
Hypotension	577.57	33.20	187	1587	32249	2324062
Bradycardia	499.21	33.20	129	1645	9852	2346459
Toxicity to various agents	435.54	33.20	152	1622	32602	2323709
Syncope	272.58	33.20	91	1683	16784	2339527
Drug interaction	259.11	33.20	101	1673	29062	2327249
Medication error	214.46	33.20	60	1714	6071	2350240
Dizziness	182.87	33.20	98	1676	58567	2297744
Cardiac failure	174.30	33.20	60	1714	12034	2344277
Sinus bradycardia	163.67	33.20	39	1735	2077	2354234
Overdose	152.02	33.20	62	1712	19845	2336466
Metabolic acidosis	140.27	33.20	43	1731	5955	2350356
Oedema peripheral	134.94	33.20	60	1714	23703	2332608
Drug hypersensitivity	128.54	33.20	72	1702	46571	2309740
Death	119.00	33.20	84	1690	81384	2274927
Nausea	118.11	33.20	95	1679	112094	2244217
Blood pressure increased	116.34	33.20	49	1725	16937	2339374
Dyspnoea	114.53	33.20	81	1693	78652	2277659
Fatigue	109.06	33.20	81	1693	84792	2271519
Hypertension	105.69	33.20	53	1721	27308	2329003
Atrial fibrillation	105.33	33.20	43	1731	13725	2342586
Cardiac arrest	105.32	33.20	44	1730	14886	2341425
Intentional overdose	102.73	33.20	40	1734	11281	2345030
Hyperkalaemia	99.54	33.20	33	1741	5860	2350451
Acute kidney injury	95.62	33.20	50	1724	28072	2328239
Loss of consciousness	89.41	33.20	42	1732	18725	2337586
Atrioventricular block complete	88.51	33.20	22	1752	1392	2354919
Chest pain	87.09	33.20	47	1727	28090	2328221
Headache	86.36	33.20	69	1705	80110	2276201
Palpitations	85.13	33.20	39	1735	16417	2339894
Fall	83.76	33.20	55	1719	47044	2309267
Drug ineffective	79.93	33.20	73	1701	101551	2254760
Asthenia	76.67	33.20	52	1722	46874	2309437
Blood glucose increased	69.45	33.20	31	1743	12259	2344052
Glycosylated haemoglobin increased	68.76	33.20	19	1755	1815	2354496
Dehydration	68.24	33.20	37	1737	22258	2334053
Renal impairment	65.27	33.20	28	1746	10064	2346247
Blood pressure decreased	64.30	33.20	27	1747	9209	2347102
Hypoglycaemia	63.32	33.20	26	1748	8381	2347930
Cardiac failure congestive	61.47	33.20	31	1743	16070	2340241
Orthostatic hypotension	60.30	33.20	19	1755	2860	2353451
Presyncope	59.02	33.20	20	1754	3783	2352528
Chest discomfort	58.35	33.20	29	1745	14566	2341745
Ischaemic stroke	57.21	33.20	19	1755	3378	2352933
Heart rate decreased	55.74	33.20	19	1755	3657	2352654
Weight decreased	49.96	33.20	33	1741	28338	2327973
Left ventricular hypertrophy	49.22	33.20	12	1762	699	2355612
Depressed level of consciousness	48.82	33.20	21	1753	7583	2348728
Blood creatinine increased	48.31	33.20	23	1751	10510	2345801
Hyperhidrosis	48.26	33.20	26	1748	15396	2340915
Left ventricular dysfunction	47.18	33.20	13	1761	1227	2355084
Cardiogenic shock	46.24	33.20	15	1759	2476	2353835
Acute respiratory distress syndrome	45.96	33.20	16	1758	3276	2353035
Stress cardiomyopathy	45.07	33.20	13	1761	1448	2354863
Electrocardiogram QT prolonged	45.03	33.20	20	1754	7794	2348517
Diarrhoea	45.01	33.20	49	1725	83515	2272796
Pulseless electrical activity	44.98	33.20	12	1762	1003	2355308
Urine albumin/creatinine ratio increased	44.21	33.20	7	1767	38	2356273
Circulatory collapse	44.05	33.20	16	1758	3704	2352607
Shock	42.90	33.20	16	1758	3988	2352323
Hypokalaemia	42.05	33.20	21	1753	10633	2345678
Angina unstable	41.45	33.20	12	1762	1354	2354957
Drug-induced liver injury	40.43	33.20	15	1759	3684	2352627
Diastolic dysfunction	40.24	33.20	10	1764	630	2355681
Bradyarrhythmia	40.23	33.20	9	1765	359	2355952
Torsade de pointes	39.56	33.20	13	1761	2233	2354078
Hepatic necrosis	39.30	33.20	11	1763	1099	2355212
Haemoglobin decreased	39.11	33.20	24	1750	18127	2338184
Mental status changes	37.75	33.20	16	1758	5566	2350745
Poisoning	36.66	33.20	13	1761	2807	2353504
Cough	36.48	33.20	29	1745	33088	2323223
Right aortic arch	36.46	33.20	6	1768	43	2356268
Electrocardiogram QT shortened	35.99	33.20	6	1768	47	2356264
Hepatitis	35.80	33.20	16	1758	6321	2349990
Somnolence	35.79	33.20	25	1749	23460	2332851
Mixed liver injury	35.73	33.20	8	1766	320	2355991
Heart rate increased	35.50	33.20	19	1755	11086	2345225
Suicide attempt	35.22	33.20	19	1755	11263	2345048
Condition aggravated	35.22	33.20	28	1746	31951	2324360
Exercise tolerance decreased	35.15	33.20	9	1765	640	2355671
Dry mouth	34.74	33.20	17	1757	8236	2348075
Blood pressure abnormal	34.64	33.20	11	1763	1694	2354617
Respiratory failure	34.64	33.20	20	1754	13508	2342803
Electrocardiogram repolarisation abnormality	34.60	33.20	7	1767	171	2356140
Lethargy	33.83	33.20	17	1757	8713	2347598
Arrhythmia	33.35	33.20	15	1759	6013	2350298

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1235.05	36.78	346	2125	15966	1728344
Hypotension	1043.12	36.78	349	2122	29305	1715005
Bradycardia	896.23	36.78	246	2225	10288	1734022
Syncope	504.94	36.78	170	2301	13999	1730311
Dizziness	334.27	36.78	162	2309	34199	1710111
Cardiac failure	298.49	36.78	112	2359	12490	1731820
Hyperkalaemia	289.22	36.78	99	2372	8448	1735862
Toxicity to various agents	278.63	36.78	136	2335	29005	1715305
Dyspnoea	252.68	36.78	155	2316	51904	1692406
Drug interaction	215.62	36.78	113	2358	27845	1716465
Acute kidney injury	200.00	36.78	116	2355	34828	1709482
Orthostatic hypotension	199.13	36.78	60	2411	3371	1740939
Asthenia	174.47	36.78	106	2365	34564	1709746
Presyncope	168.70	36.78	50	2421	2648	1741662
Atrial fibrillation	142.05	36.78	70	2401	15041	1729269
Oedema peripheral	134.25	36.78	68	2403	15482	1728828
Blood pressure increased	129.13	36.78	59	2412	10694	1733616
Heart rate decreased	124.50	36.78	40	2431	2769	1741541
Drug ineffective	116.52	36.78	106	2365	63695	1680615
Atrioventricular block	110.57	36.78	31	2440	1340	1742970
Fatigue	105.78	36.78	91	2380	50690	1693620
Cardiogenic shock	104.87	36.78	34	2437	2420	1741890
Cardiac failure chronic	102.39	36.78	25	2446	623	1743687
Blood pressure decreased	98.19	36.78	44	2427	7602	1736708
Overdose	93.82	36.78	55	2416	16646	1727664
Cardio-respiratory arrest	93.00	36.78	45	2426	9248	1735062
Pulmonary oedema	91.30	36.78	40	2431	6546	1737764
Atrioventricular block complete	90.72	36.78	27	2444	1444	1742866
Ejection fraction decreased	87.42	36.78	29	2442	2216	1742094
Cardiomegaly	86.31	36.78	29	2442	2305	1742005
Cardiac failure congestive	82.35	36.78	49	2422	15221	1729089
Cardiac arrest	80.43	36.78	49	2422	15881	1728429
Chest pain	79.99	36.78	53	2418	19861	1724449
Nausea	77.76	36.78	77	2394	51119	1693191
Bradyarrhythmia	77.28	36.78	18	2453	364	1743946
Chronic kidney disease	75.71	36.78	31	2440	4286	1740024
Condition aggravated	74.73	36.78	52	2419	21098	1723212
Cough	72.06	36.78	49	2422	19148	1725162
Sinus bradycardia	71.39	36.78	24	2447	1909	1742401
Mitral valve incompetence	71.28	36.78	24	2447	1918	1742392
Nodal arrhythmia	70.96	36.78	15	2456	190	1744120
Blood creatinine increased	70.64	36.78	43	2428	13903	1730407
Loss of consciousness	70.60	36.78	44	2427	14831	1729479
Hypertension	69.12	36.78	48	2423	19400	1724910
Bundle branch block left	68.03	36.78	19	2452	808	1743502
Sinus arrest	67.58	36.78	16	2455	348	1743962
Cardioactive drug level increased	67.47	36.78	15	2456	244	1744066
Arrhythmia	65.83	36.78	31	2440	5985	1738325
Angina pectoris	64.75	36.78	29	2442	4989	1739321
Shock	63.28	36.78	27	2444	4134	1740176
Intentional product misuse	62.80	36.78	32	2439	7326	1736984
Renal impairment	62.42	36.78	38	2433	12276	1732034
Hypoglycaemia	61.46	36.78	33	2438	8405	1735905
Mouth breathing	57.33	36.78	10	2461	40	1744270
Hypovolaemia	56.29	36.78	18	2453	1222	1743088
Vertigo	55.32	36.78	25	2446	4388	1739922
Hyperhidrosis	54.37	36.78	35	2436	12453	1731857
Atrioventricular block second degree	54.13	36.78	15	2456	619	1743691
Medication error	53.60	36.78	25	2446	4718	1739592
Nodal rhythm	53.02	36.78	13	2458	329	1743981
Fall	52.81	36.78	47	2424	27167	1717143
Hypertensive crisis	52.61	36.78	18	2453	1509	1742801
Rales	52.33	36.78	16	2455	936	1743374
Dehydration	52.21	36.78	39	2432	17619	1726691
Oedema	50.10	36.78	27	2444	6921	1737389
Contraindicated product administered	49.66	36.78	17	2454	1427	1742883
Tachycardia	49.15	36.78	33	2438	12595	1731715
Troponin I increased	48.74	36.78	12	2459	309	1744001
Blood urea increased	47.62	36.78	23	2448	4688	1739622
Blood glucose increased	46.89	36.78	30	2441	10554	1733756
Somnolence	45.12	36.78	35	2436	16704	1727606
Peripheral coldness	44.96	36.78	15	2456	1163	1743147
Cardiac failure acute	44.58	36.78	15	2456	1194	1743116
Decreased appetite	43.86	36.78	40	2431	23831	1720479
Drug hypersensitivity	43.76	36.78	33	2438	15102	1729208
Respiratory arrest	42.95	36.78	23	2448	5816	1738494
Anaemia	42.13	36.78	43	2428	29414	1714896
Left ventricular dilatation	41.74	36.78	8	2463	59	1744251
Death	41.07	36.78	74	2397	87369	1656941
Blood pressure inadequately controlled	41.05	36.78	12	2459	601	1743709
Orthopnoea	40.80	36.78	12	2459	614	1743696
Blood lactic acid increased	40.59	36.78	13	2458	886	1743424
Poisoning	40.37	36.78	17	2454	2515	1741795
Arterial spasm	39.93	36.78	7	2464	29	1744281
Oesophageal discomfort	39.02	36.78	7	2464	34	1744276
Headache	38.33	36.78	44	2427	34332	1709978
Prinzmetal angina	38.30	36.78	9	2462	189	1744121
Dizziness postural	37.18	36.78	12	2459	838	1743472
Conjunctival scar	37.13	36.78	6	2465	13	1744297

Pharmacologic Action:

Source	Code	Description
ATC	C07AG02	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Alpha and beta blocking agents
ATC	C07FX06	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D058668	Adrenergic alpha-1 Receptor Antagonists
FDA MoA	N0000009923	Adrenergic beta1-Antagonists
FDA MoA	N0000009924	Adrenergic beta2-Antagonists
FDA EPC	N0000175553	alpha-Adrenergic Blocker
FDA EPC	N0000175556	beta-Adrenergic Blocker
MeSH PA	D000317	Adrenergic alpha-Antagonists
MeSH PA	D018674	Adrenergic Antagonists
MeSH PA	D000319	Adrenergic beta-Antagonists
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D000975	Antioxidants
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D020011	Protective Agents
CHEBI has role	CHEBI:35620	vasodilator agent
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35530	beta-adrenergic antagonist
CHEBI has role	CHEBI:35674	antihypertensive agent
CHEBI has role	CHEBI:37890	alpha-adrenergic antagonist
MeSH PA	D014665	Vasodilator Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Chronic heart failure	indication	48447003
Left ventricular cardiac dysfunction	indication	429589006
Atrial fibrillation	off-label use	49436004	DOID:0060224
Diastolic heart failure	off-label use	418304008	DOID:9775
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation	off-label use
Bronchospasm	contraindication	4386001
Complete atrioventricular block	contraindication	27885002
Sick sinus syndrome	contraindication	36083008	DOID:13884
Anaphylaxis	contraindication	39579001
Low blood pressure	contraindication	45007003
Sinus bradycardia	contraindication	49710005
Hepatic failure	contraindication	59927004
Chronic bronchitis	contraindication	63480004	DOID:6132
Diabetes mellitus	contraindication	73211009	DOID:9351
Prinzmetal angina	contraindication	87343002
Pulmonary emphysema	contraindication	87433001
Cardiogenic shock	contraindication	89138009
Second degree atrioventricular block	contraindication	195042002
Asthma	contraindication	195967001	DOID:2841
Pregnancy, function	contraindication	289908002
Peripheral vascular disease	contraindication	400047006
Intraoperative floppy iris syndrome	contraindication	418801006
Acutely Decompensated HF Requiring Parenteral Inotropic Therapy	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.13	acidic
pKa2	7.88	Basic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
10MG	COREG CR	SMITHKLINE BEECHAM	N022012	Oct. 20, 2006	RX	CAPSULE, EXTENDED RELEASE	ORAL	7268156	June 27, 2023	TREATMENT OF CONGESTIVE HEART FAILURE
10MG	COREG CR	SMITHKLINE BEECHAM	N022012	Oct. 20, 2006	RX	CAPSULE, EXTENDED RELEASE	ORAL	7268156	June 27, 2023	TREATMENT OF HYPERTENSION
20MG	COREG CR	SMITHKLINE BEECHAM	N022012	Oct. 20, 2006	RX	CAPSULE, EXTENDED RELEASE	ORAL	7268156	June 27, 2023	TREATMENT OF CONGESTIVE HEART FAILURE
20MG	COREG CR	SMITHKLINE BEECHAM	N022012	Oct. 20, 2006	RX	CAPSULE, EXTENDED RELEASE	ORAL	7268156	June 27, 2023	TREATMENT OF HYPERTENSION
40MG	COREG CR	SMITHKLINE BEECHAM	N022012	Oct. 20, 2006	RX	CAPSULE, EXTENDED RELEASE	ORAL	7268156	June 27, 2023	TREATMENT OF CONGESTIVE HEART FAILURE
40MG	COREG CR	SMITHKLINE BEECHAM	N022012	Oct. 20, 2006	RX	CAPSULE, EXTENDED RELEASE	ORAL	7268156	June 27, 2023	TREATMENT OF HYPERTENSION
80MG	COREG CR	SMITHKLINE BEECHAM	N022012	Oct. 20, 2006	RX	CAPSULE, EXTENDED RELEASE	ORAL	7268156	June 27, 2023	TREATMENT OF CONGESTIVE HEART FAILURE
80MG	COREG CR	SMITHKLINE BEECHAM	N022012	Oct. 20, 2006	RX	CAPSULE, EXTENDED RELEASE	ORAL	7268156	June 27, 2023	TREATMENT OF HYPERTENSION

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN	ANTAGONIST	Ki	9.90	IUPHAR	CHEMBL
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN	ANTAGONIST	Ki	9.50	IUPHAR	CHEMBL
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN	ANTAGONIST	Ki	9.40	IUPHAR
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	6.13	DRUG MATRIX
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	7.31	DRUG MATRIX
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	7.40	DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	6.93	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	6.27	DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	8.48	DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.93	DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	7.82	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	7.22	DRUG MATRIX
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	6.15	DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	7.37	DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.71	DRUG MATRIX
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	7.89	DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	6.17	DRUG MATRIX
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN	ANTAGONIST	Ki	9.05	DRUG MATRIX
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN	ANTAGONIST	Ki	8.66	WOMBAT-PK
Solute carrier family 22 member 2	Transporter	O15244	S22A2_HUMAN		IC50	5.12	CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	6.46	CHEMBL
Multidrug and toxin extrusion protein 1	Transporter	Q96FL8	S47A1_HUMAN		IC50	4.03	CHEMBL
Amyloid beta A4 protein	Unclassified	P05067	A4_HUMAN		IC50	4.52	CHEMBL
5-hydroxytryptamine receptor 4	GPCR		5HT4R_CAVPO		Ki	6.74	DRUG MATRIX
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	8.71	DRUG MATRIX
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT		Ki	6.23	DRUG MATRIX
Beta-1 adrenergic receptor	GPCR		ADRB1_RAT		Ki	9.09	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	8.50	CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	8.11	CHEMBL

External reference:

ID	Source
D000077261	MESH_DESCRIPTOR_UI
4021041	VUID
N0000148505	NUI
C0054836	UMLSCUI
D00255	KEGG_DRUG
0K47UL67F2	UNII
5333	INN_ID
108551001	SNOMEDCT_US
4021041	VANDF
119032	MMSL
004167	NDDF
d03847	MMSL
4363	MMSL
20352	RXNORM
386870007	SNOMEDCT_US
CHEMBL723	ChEMBL_ID
610309-89-2	SECONDARY_CAS_RN
CVD	PDB_CHEM_ID
DB01136	DRUGBANK_ID
CHEBI:3441	CHEBI
551	IUPHAR_LIGAND_ID
CHEMBL1201167	ChEMBL_ID
2585	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-3370	CAPSULE, EXTENDED RELEASE	10 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-3371	CAPSULE, EXTENDED RELEASE	20 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-3372	CAPSULE, EXTENDED RELEASE	40 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-3373	CAPSULE, EXTENDED RELEASE	80 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-3383	CAPSULE, EXTENDED RELEASE	10 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-3385	CAPSULE, EXTENDED RELEASE	20 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-3387	CAPSULE, EXTENDED RELEASE	40 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-3388	CAPSULE, EXTENDED RELEASE	80 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-4139	TABLET, FILM COATED	3.13 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-4140	TABLET, FILM COATED	6.25 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-4141	TABLET, FILM COATED	12.50 mg	ORAL	NDA	17 sections
COREG	HUMAN PRESCRIPTION DRUG LABEL	1	0007-4142	TABLET, FILM COATED	25 mg	ORAL	NDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0051	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0135	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7295	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7296	TABLET, FILM COATED	25 mg	ORAL	ANDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3631	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3632	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3633	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3634	TABLET, FILM COATED	25 mg	ORAL	ANDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-6583	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	18 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-6584	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	18 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-6585	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	18 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-6586	TABLET, FILM COATED	25 mg	ORAL	ANDA	18 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7944	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	18 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7945	TABLET, FILM COATED	12.50 mg	ORAL	ANDA	18 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7946	TABLET, FILM COATED	25 mg	ORAL	ANDA	18 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8018	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	18 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5221	TABLET, FILM COATED	3.13 mg	ORAL	ANDA	17 sections
Carvedilol	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5222	TABLET, FILM COATED	6.25 mg	ORAL	ANDA	17 sections