carvedilol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vasodilators 522 72956-09-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carvedilol
  • carvedilol phosphate
  • carvediol
  • carvedilol hydrochloride
  • carvedilol HCl
  • BM 14,190
A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.
  • Molecular weight: 406.48
  • Formula: C24H26N2O4
  • CLOGP: 4.04
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 75.74
  • ALOGS: -4.96
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
37.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.03 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 14, 1995 FDA SMITHKLINE BEECHAM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1070.07 10.10 1042 80846 90708 46513466
Myocardial infarction 320.10 10.10 596 81292 96932 46507242
Cardiac failure 271.60 10.10 496 81392 79452 46524722
Rheumatoid arthritis 215.91 10.10 76 81812 240139 46364035
Hypotension 198.90 10.10 871 81017 231718 46372456
Bradycardia 191.44 10.10 384 81504 65914 46538260
Drug ineffective 176.63 10.10 606 81282 677232 45926942
Acute myocardial infarction 144.11 10.10 225 81663 31699 46572475
Cardiomyopathy 130.70 10.10 151 81737 15922 46588252
Hyperkalaemia 114.54 10.10 266 81622 50443 46553731
Acute kidney injury 111.20 10.10 751 81137 235104 46369070
Ejection fraction decreased 106.57 10.10 144 81744 17793 46586381
Gastrointestinal haemorrhage 100.06 10.10 331 81557 77042 46527132
Treatment failure 97.30 10.10 22 81866 93065 46511109
Chronic kidney disease 96.27 10.10 218 81670 40653 46563521
Coronary artery disease 93.21 10.10 192 81696 33560 46570614
Atrial fibrillation 89.08 10.10 389 81499 103201 46500973
Renal failure 79.67 10.10 402 81486 113192 46490982
Dyspnoea 77.49 10.10 1301 80587 514247 46089927
Cardiac disorder 71.98 10.10 204 81684 43654 46560520
Joint swelling 71.48 10.10 113 81775 165960 46438214
Maternal exposure during pregnancy 71.26 10.10 46 81842 102503 46501671
International normalised ratio increased 71.11 10.10 212 81676 46671 46557503
Syncope 69.38 10.10 365 81523 104438 46499736
Infusion related reaction 66.84 10.10 48 81840 101160 46503014
Synovitis 66.76 10.10 13 81875 61062 46543112
Contraindicated product administered 65.60 10.10 29 81859 79918 46524256
Cerebrovascular accident 64.91 10.10 349 81539 100690 46503484
Oedema peripheral 63.83 10.10 489 81399 159217 46444957
Pain 62.51 10.10 536 81352 476412 46127762
Exposure during pregnancy 61.97 10.10 59 81829 108153 46496021
Arthralgia 61.08 10.10 382 81506 364221 46239953
Renal impairment 60.67 10.10 275 81613 74097 46530077
Chest pain 57.15 10.10 515 81373 175809 46428365
Hypoglycaemia 56.92 10.10 217 81671 54132 46550042
Off label use 56.62 10.10 412 81476 379429 46224745
Drug intolerance 56.05 10.10 108 81780 146941 46457233
Drug hypersensitivity 54.01 10.10 232 81656 243593 46360581
Lower respiratory tract infection 53.73 10.10 15 81873 55074 46549100
Atrioventricular block 53.71 10.10 63 81825 6748 46597426
Musculoskeletal stiffness 53.16 10.10 56 81832 97937 46506237
Hypertensive crisis 50.68 10.10 88 81800 13527 46590647
Drug abuse 50.46 10.10 24 81864 63384 46540790
Cardioactive drug level increased 50.40 10.10 36 81852 2023 46602151
Systemic lupus erythematosus 49.87 10.10 26 81862 65154 46539020
Pulmonary oedema 49.42 10.10 199 81689 50906 46553268
Anaemia 48.87 10.10 673 81215 255106 46349068
Congestive cardiomyopathy 48.68 10.10 55 81833 5658 46598516
Injection site pain 46.95 10.10 72 81816 107080 46497094
Mental status changes 46.60 10.10 160 81728 37928 46566246
Blood glucose increased 46.40 10.10 249 81639 71764 46532410
Full blood count decreased 46.33 10.10 113 81775 22098 46582076
Abortion spontaneous 46.23 10.10 10 81878 43636 46560538
Death 45.28 10.10 833 81055 334715 46269459
Therapeutic product effect decreased 45.03 10.10 47 81841 82554 46521620
Fluid retention 44.84 10.10 193 81695 50853 46553321
Gastrointestinal tract mucosal pigmentation 43.59 10.10 21 81867 559 46603615
Cardiomegaly 41.99 10.10 94 81794 17388 46586786
Febrile neutropenia 41.05 10.10 64 81824 94563 46509611
Cardiac failure chronic 40.88 10.10 40 81848 3484 46600690
Ischaemic cardiomyopathy 40.78 10.10 35 81853 2575 46601599
Haemoglobin decreased 39.91 10.10 373 81515 128576 46475598
Pyrexia 39.58 10.10 406 81482 348396 46255778
Cardiac arrest 39.02 10.10 282 81606 90117 46514057
Unresponsive to stimuli 38.35 10.10 134 81754 32040 46572134
Dehydration 37.77 10.10 437 81451 159103 46445071
Blood loss anaemia 36.79 10.10 59 81829 8498 46595676
Cardiac failure acute 36.52 10.10 57 81831 8021 46596153
Rash 36.45 10.10 425 81463 356087 46248087
Ventricular arrhythmia 36.31 10.10 37 81851 3384 46600790
Coronary arterial stent insertion 36.16 10.10 34 81854 2819 46601355
Blood creatinine increased 35.11 10.10 242 81646 76161 46528013
Hepatic enzyme increased 34.83 10.10 56 81832 81731 46522443
Blood pressure decreased 34.37 10.10 194 81694 56965 46547209
Sinus bradycardia 34.11 10.10 75 81813 13707 46590467
Glycosylated haemoglobin increased 33.77 10.10 65 81823 10811 46593363
Pregnancy 33.70 10.10 4 81884 27133 46577041
Hypersensitivity 33.26 10.10 143 81745 150178 46453996
Fluid overload 33.08 10.10 114 81774 27071 46577103
Dizziness 32.87 10.10 805 81083 339609 46264565
Hand deformity 32.64 10.10 10 81878 34564 46569610
Arrhythmia 32.35 10.10 134 81754 34707 46569467
Mitral valve incompetence 32.21 10.10 89 81799 18763 46585411
Hypertension 32.08 10.10 503 81385 195853 46408321
Isosthenuria 31.78 10.10 11 81877 120 46604054
Orthopnoea 31.62 10.10 45 81843 5835 46598339
Renal disorder 30.82 10.10 110 81778 26576 46577598
Arthropathy 30.71 10.10 64 81824 84636 46519538
Glossodynia 30.68 10.10 20 81868 44353 46559821
Angina pectoris 30.61 10.10 110 81778 26665 46577509
Therapeutic product effect incomplete 30.10 10.10 57 81831 78096 46526078
Spinal epidural haematoma 29.59 10.10 18 81870 770 46603404
Injection site erythema 28.91 10.10 54 81834 74373 46529801
Myocardial ischaemia 28.90 10.10 67 81821 12682 46591492
Asthenia 28.35 10.10 730 81158 310345 46293829
Pyelitis 28.32 10.10 11 81877 170 46604004
Alopecia 28.24 10.10 168 81720 162246 46441928
Pulse absent 28.24 10.10 39 81849 4917 46599257
Glomerular filtration rate decreased 28.22 10.10 63 81825 11631 46592543
Electrocardiogram PR shortened 28.14 10.10 11 81877 173 46604001
Myxoedema coma 28.12 10.10 14 81874 401 46603773
Blood potassium increased 27.90 10.10 79 81809 16888 46587286
Asthma 27.76 10.10 76 81812 91466 46512708
Pericardial effusion 27.57 10.10 103 81785 25440 46578734
Drug interaction 27.25 10.10 504 81384 202590 46401584
Erythema 26.85 10.10 144 81744 142676 46461498
Bladder hypertrophy 26.14 10.10 11 81877 211 46603963
End stage renal disease 25.87 10.10 41 81847 5845 46598329
Suicidal ideation 25.54 10.10 37 81851 56345 46547829
Angina unstable 24.54 10.10 46 81842 7502 46596672
Neutropenia 23.91 10.10 150 81738 143054 46461120
Left ventricular hypertrophy 23.82 10.10 36 81852 4927 46599247
Migraine 23.67 10.10 55 81833 69971 46534203
Peritonitis bacterial 23.61 10.10 49 81839 8604 46595570
Ventricular hypokinesia 23.10 10.10 32 81856 4046 46600128
Headache 23.07 10.10 651 81237 477701 46126473
Atrioventricular block first degree 23.04 10.10 40 81848 6146 46598028
Infection 22.79 10.10 139 81749 133453 46470721
Intracardiac thrombus 22.77 10.10 24 81864 2284 46601890
Blood pressure inadequately controlled 22.64 10.10 33 81855 4373 46599801
Vessel puncture site haemorrhage 22.36 10.10 8 81880 97 46604077
Implantable defibrillator insertion 22.33 10.10 12 81876 404 46603770
Left ventricular dysfunction 22.27 10.10 53 81835 10202 46593972
Arterial stenosis 22.23 10.10 14 81874 637 46603537
Medication error 21.36 10.10 109 81779 30802 46573372
Injection site reaction 21.09 10.10 32 81856 47817 46556357
Blood glucose decreased 21.07 10.10 77 81811 18815 46585359
Dialysis 20.60 10.10 51 81837 10065 46594109
Leukopenia 20.53 10.10 57 81831 68286 46535888
Ventricular tachycardia 20.51 10.10 71 81817 16896 46587278
Acute respiratory failure 20.31 10.10 103 81785 29035 46575139
Ischaemic stroke 20.23 10.10 70 81818 16652 46587522
Fall 20.22 10.10 736 81152 328361 46275813
Blood pressure abnormal 20.20 10.10 57 81831 12160 46592014
Coronary artery occlusion 19.94 10.10 44 81844 8058 46596116
Brain natriuretic peptide increased 19.90 10.10 32 81856 4618 46599556
Tricuspid valve incompetence 19.82 10.10 61 81827 13656 46590518
Device expulsion 19.61 10.10 12 81876 27530 46576644
Diastolic dysfunction 19.43 10.10 34 81854 5258 46598916
Upper gastrointestinal haemorrhage 19.33 10.10 69 81819 16669 46587505
Respiratory failure 18.67 10.10 251 81637 94565 46509609
Urine albumin/creatinine ratio increased 18.57 10.10 8 81880 163 46604011
Atrial flutter 18.50 10.10 46 81842 9102 46595072
Urticaria 18.41 10.10 126 81762 117766 46486408
Basal ganglia haemorrhage 18.22 10.10 12 81876 590 46603584
Creatinine renal clearance increased 17.92 10.10 11 81877 478 46603696
Aortic valve incompetence 17.71 10.10 35 81853 5935 46598239
Red blood cell sedimentation rate increased 17.70 10.10 9 81879 22880 46581294
Arteriosclerosis 17.68 10.10 47 81841 9686 46594488
Pericarditis 17.63 10.10 10 81878 23917 46580257
Foetal exposure during pregnancy 17.31 10.10 17 81871 30730 46573444
Electrocardiogram QT shortened 17.20 10.10 7 81881 123 46604051
Atrioventricular block complete 17.19 10.10 40 81848 7587 46596587
Melaena 17.18 10.10 95 81793 27677 46576497
Lower gastrointestinal haemorrhage 17.17 10.10 39 81849 7281 46596893
Renal hypoplasia 16.92 10.10 5 81883 31 46604143
Femoral artery dissection 16.92 10.10 5 81883 31 46604143
Injection site swelling 16.80 10.10 28 81860 40299 46563875
Cardiogenic shock 16.80 10.10 65 81823 16319 46587855
Genotype drug resistance test positive 16.74 10.10 11 81877 539 46603635
Pulseless electrical activity 16.61 10.10 38 81850 7129 46597045
Intentional self-injury 16.56 10.10 11 81877 24155 46580019
Blood urea increased 16.55 10.10 88 81800 25264 46578910
Hypertensive emergency 16.27 10.10 17 81871 1601 46602573
Oropharyngeal pain 16.12 10.10 71 81817 74097 46530077
Electrocardiogram ST segment 16.04 10.10 3 81885 0 46604174
Vena cava injury 16.04 10.10 3 81885 0 46604174
Product use in unapproved indication 15.88 10.10 93 81795 90180 46513994
Tendonitis 15.68 10.10 3 81885 14274 46589900
Pleural effusion 15.67 10.10 218 81670 82734 46521440
Nephropathy 15.65 10.10 30 81858 4975 46599199
Nephrogenic anaemia 15.59 10.10 18 81870 1895 46602279
Hypouricaemia 15.59 10.10 7 81881 158 46604016
Chronic obstructive pulmonary disease 15.51 10.10 162 81726 57471 46546703
Platelet dysfunction 15.37 10.10 6 81882 94 46604080
Renal injury 15.27 10.10 44 81844 9497 46594677
Hypovolaemia 15.25 10.10 45 81843 9843 46594331
Cerebral infarction 15.18 10.10 81 81807 23285 46580889
Toxic neuropathy 14.96 10.10 9 81879 377 46603797
Impaired healing 14.86 10.10 26 81862 36717 46567457
Product use issue 14.85 10.10 101 81787 94543 46509631
Mucocutaneous haemorrhage 14.41 10.10 5 81883 55 46604119
Pernicious anaemia 14.36 10.10 11 81877 688 46603486
Haematocrit decreased 14.34 10.10 108 81780 34949 46569225
Vascular stent stenosis 14.25 10.10 10 81878 546 46603628
Calcium deficiency 14.24 10.10 12 81876 861 46603313
Embolic stroke 14.17 10.10 24 81864 3615 46600559
Left ventricular dilatation 14.13 10.10 8 81880 299 46603875
Bone marrow failure 13.90 10.10 19 81869 29650 46574524
Blood pressure increased 13.86 10.10 305 81583 126361 46477813
Pulmonary congestion 13.80 10.10 57 81831 14742 46589432
Insulin-requiring type 2 diabetes mellitus 13.80 10.10 5 81883 63 46604111
Anti-neutrophil cytoplasmic antibody positive vasculitis 13.79 10.10 17 81871 1918 46602256
Abdominal pain 13.76 10.10 303 81585 229728 46374446
Herbal interaction 13.73 10.10 5 81883 64 46604110
Hypervolaemia 13.70 10.10 16 81872 1706 46602468
Suicide attempt 13.65 10.10 50 81838 54986 46549188
Carbohydrate antigen 15-3 increased 13.65 10.10 12 81876 912 46603262
Injection site pruritus 13.60 10.10 31 81857 39712 46564462
Urinary tract infection 13.60 10.10 493 81395 219773 46384401
Coronary artery bypass 13.57 10.10 19 81869 2426 46601748
Wound 13.38 10.10 35 81853 42767 46561407
Tremor 13.31 10.10 134 81754 115505 46488669
Therapy cessation 13.22 10.10 86 81802 26543 46577631
Renal artery stenosis 13.21 10.10 16 81872 1772 46602402
Shock 13.03 10.10 74 81814 21771 46582403
Malignant neoplasm progression 13.02 10.10 64 81824 64862 46539312
Unevaluable event 13.00 10.10 131 81757 46044 46558130
Renal tubular injury 12.99 10.10 8 81880 350 46603824
Herpes zoster 12.98 10.10 68 81820 67804 46536370
Cytomegalovirus infection 12.78 10.10 8 81880 18136 46586038
Psoriatic arthropathy 12.75 10.10 28 81860 36351 46567823
Cholestatic liver injury 12.75 10.10 17 81871 2073 46602101
Sinusitis 12.71 10.10 156 81732 129612 46474562
Condition aggravated 12.67 10.10 330 81558 244722 46359452
Hypertensive encephalopathy 12.57 10.10 10 81878 661 46603513
Abdominal discomfort 12.54 10.10 188 81700 150977 46453197
Decreased appetite 12.49 10.10 436 81452 193400 46410774
Cognitive disorder 12.43 10.10 29 81859 36854 46567320
Plasma cell myeloma 12.43 10.10 126 81762 44352 46559822
Transfusion 12.37 10.10 51 81837 13180 46590994
Catheterisation cardiac 12.34 10.10 24 81864 4023 46600151
Cardiac operation 12.32 10.10 19 81869 2647 46601527
Nasopharyngitis 12.27 10.10 193 81695 153805 46450369
Renal atrophy 12.10 10.10 13 81875 1264 46602910
Agitation 12.07 10.10 53 81835 55362 46548812
Glomerulonephritis rapidly progressive 12.07 10.10 10 81878 701 46603473
Anaphylactic reaction 12.06 10.10 50 81838 53062 46551112
Foot deformity 12.02 10.10 6 81882 15419 46588755
Basal cell carcinoma 11.92 10.10 11 81877 20476 46583698
Occult blood positive 11.91 10.10 22 81866 3548 46600626
Traumatic renal injury 11.90 10.10 3 81885 9 46604165
Electrocardiogram abnormal 11.87 10.10 33 81855 6979 46597195
Haemorrhage intracranial 11.86 10.10 49 81839 12675 46591499
Oral herpes 11.77 10.10 10 81878 19380 46584794
Bradyarrhythmia 11.75 10.10 16 81872 1990 46602184
Phaeochromocytoma crisis 11.74 10.10 6 81882 182 46603992
Arterial occlusive disease 11.72 10.10 26 81862 4778 46599396
Bundle branch block left 11.72 10.10 31 81857 6368 46597806
Peripheral coldness 11.70 10.10 41 81847 9814 46594360
Breast cancer recurrent 11.69 10.10 23 81865 3888 46600286
Gastrointestinal arteriovenous malformation 11.65 10.10 9 81879 570 46603604
Gout 11.60 10.10 45 81843 11311 46592863
Refractory anaemia with an excess of blasts 11.56 10.10 8 81880 427 46603747
Hypovolaemic shock 11.48 10.10 27 81861 5156 46599018
Intercepted product dispensing error 11.42 10.10 5 81883 106 46604068
Pneumonia 11.41 10.10 786 81102 375534 46228640
Chronic left ventricular failure 11.37 10.10 7 81881 306 46603868
Multiple sclerosis relapse 11.31 10.10 37 81851 42088 46562086
Subdural haematoma 11.30 10.10 49 81839 12948 46591226
Drug dependence 11.21 10.10 11 81877 19890 46584284
Bursitis 11.14 10.10 11 81877 19831 46584343
Extrapyramidal disorder 11.11 10.10 3 81885 11265 46592909
Carcinoembryonic antigen increased 11.05 10.10 13 81875 1396 46602778
Aortic stenosis 11.02 10.10 24 81864 4358 46599816
Loss of consciousness 11.01 10.10 258 81630 107980 46496194
Arthritis 10.92 10.10 85 81803 77231 46526943
Arteriovenous fistula thrombosis 10.90 10.10 6 81882 212 46603962
Epinephrine increased 10.86 10.10 3 81885 14 46604160
Photophobia 10.83 10.10 6 81882 14538 46589636
Supraventricular extrasystoles 10.82 10.10 23 81865 4106 46600068
Breath sounds 10.70 10.10 5 81883 124 46604050
Metabolic acidosis 10.43 10.10 109 81779 38671 46565503
Neutrophil count decreased 10.41 10.10 40 81848 43386 46560788
Quadriplegia 10.40 10.10 14 81874 1723 46602451
Injection site urticaria 10.36 10.10 4 81884 11963 46592211
Post procedural hypothyroidism 10.35 10.10 5 81883 134 46604040
Long QT syndrome 10.30 10.10 19 81869 3061 46601113
Hepatic vein dilatation 10.24 10.10 3 81885 18 46604156
Premature baby 10.21 10.10 10 81878 18102 46586072
Cardiac pacemaker insertion 10.16 10.10 21 81867 3678 46600496
Retinopathy hypertensive 10.14 10.10 6 81882 244 46603930

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1092.36 10.53 1332 92489 83075 29775582
Cardiac failure 384.22 10.53 823 92998 82595 29776062
Myocardial infarction 356.78 10.53 1030 92791 124595 29734062
Hypotension 298.41 10.53 1330 92491 199235 29659422
Bradycardia 231.64 10.53 583 93238 64943 29793714
Coronary artery disease 147.88 10.53 415 93406 49297 29809360
Drug abuse 141.06 10.53 41 93780 82031 29776626
Acute myocardial infarction 135.56 10.53 419 93402 52520 29806137
Ejection fraction decreased 123.69 10.53 192 93629 14983 29843674
Syncope 123.41 10.53 560 93261 84343 29774314
Hyperkalaemia 121.43 10.53 468 93353 65542 29793115
Cardiac failure chronic 114.38 10.53 115 93706 5748 29852909
Ischaemic cardiomyopathy 111.07 10.53 117 93704 6180 29852477
Dizziness 109.30 10.53 1009 92812 193900 29664757
Atrial fibrillation 97.67 10.53 626 93195 107498 29751159
Cardiac failure acute 94.63 10.53 130 93691 9079 29849578
Off label use 93.19 10.53 433 93388 248857 29609800
Dyspnoea 91.70 10.53 1508 92313 331787 29526870
Gastrointestinal haemorrhage 89.94 10.53 506 93315 82940 29775717
Foetal exposure during pregnancy 86.20 10.53 8 93813 36863 29821794
Cardiac disorder 86.11 10.53 298 93523 39595 29819062
Pyrexia 85.68 10.53 556 93265 293933 29564724
Cardiomyopathy 79.62 10.53 158 93663 14985 29843672
Neutropenia 77.98 10.53 180 93641 128360 29730297
Ventricular tachycardia 73.66 10.53 202 93619 23660 29834997
Rheumatoid arthritis 71.82 10.53 20 93801 41177 29817480
Mitral valve incompetence 68.27 10.53 137 93684 13097 29845560
International normalised ratio increased 67.88 10.53 313 93508 47426 29811231
Febrile neutropenia 66.65 10.53 147 93674 106546 29752111
Drug ineffective 65.77 10.53 716 93105 339671 29518986
Chronic kidney disease 62.88 10.53 260 93561 37578 29821079
Left ventricular dilatation 59.04 10.53 32 93789 600 29858057
Blood pressure decreased 51.02 10.53 286 93535 46789 29811868
Blood potassium increased 49.78 10.53 137 93684 16076 29842581
Cerebrovascular accident 49.60 10.53 438 93383 83039 29775618
Treatment failure 48.43 10.53 24 93797 34655 29824002
Cardiomegaly 47.97 10.53 126 93695 14383 29844274
Hypoglycaemia 45.84 10.53 295 93526 50686 29807971
Toxicity to various agents 44.79 10.53 348 93473 176835 29681822
Pulmonary oedema 44.28 10.53 262 93559 43713 29814944
Renal impairment 43.62 10.53 429 93392 83755 29774902
Coronary artery bypass 43.02 10.53 66 93755 5096 29853561
Ventricular hypokinesia 42.46 10.53 59 93762 4164 29854493
Drug reaction with eosinophilia and systemic symptoms 42.45 10.53 18 93803 28470 29830187
Angina pectoris 42.29 10.53 194 93627 29324 29829333
Blood creatinine increased 41.82 10.53 454 93367 90921 29767736
Coronary arterial stent insertion 41.28 10.53 58 93763 4136 29854521
Cardiogenic shock 40.85 10.53 131 93690 16730 29841927
Orthopnoea 40.61 10.53 60 93761 4480 29854177
Blood loss anaemia 40.59 10.53 80 93741 7547 29851110
Chest pain 38.97 10.53 550 93271 117077 29741580
Product use in unapproved indication 38.64 10.53 111 93710 73582 29785075
Acute kidney injury 38.26 10.53 1125 92696 272717 29585940
Presyncope 38.22 10.53 124 93697 15932 29842725
N-terminal prohormone brain natriuretic peptide abnormal 37.72 10.53 14 93807 100 29858557
Agitation 37.57 10.53 70 93751 54003 29804654
Suicidal ideation 35.94 10.53 36 93785 36078 29822579
Atrioventricular block 35.91 10.53 74 93747 7208 29851449
Premature baby 35.56 10.53 5 93816 16686 29841971
Completed suicide 35.30 10.53 471 93350 99021 29759636
Carotid sinus syndrome 34.43 10.53 10 93811 28 29858629
Aggression 34.26 10.53 39 93782 36868 29821789
Fluid retention 34.12 10.53 162 93659 24836 29833821
Hepatocellular injury 33.54 10.53 19 93802 25452 29833205
Fractured coccyx 33.21 10.53 14 93807 145 29858512
Depression 33.12 10.53 158 93663 90279 29768378
Leukopenia 32.92 10.53 80 93741 56079 29802578
Malignant neoplasm progression 32.91 10.53 116 93705 72171 29786486
Suicide attempt 32.75 10.53 40 93781 36657 29822000
Drug dependence 32.46 10.53 13 93808 21282 29837375
Cardiac arrest 32.30 10.53 438 93383 92412 29766245
Bradyarrhythmia 32.18 10.53 35 93786 1917 29856740
Blood thyroid stimulating hormone abnormal 31.99 10.53 14 93807 160 29858497
Cardioactive drug level increased 31.69 10.53 32 93789 1607 29857050
Intentional overdose 31.27 10.53 51 93770 41430 29817227
Asthenia 30.83 10.53 909 92912 220381 29638276
Mouth breathing 29.35 10.53 11 93810 81 29858576
Heart rate decreased 29.34 10.53 137 93684 20857 29837800
Congestive cardiomyopathy 28.83 10.53 64 93757 6563 29852094
Brain natriuretic peptide abnormal 28.71 10.53 13 93808 162 29858495
Mucosal inflammation 28.54 10.53 32 93789 30462 29828195
Electrocardiogram QRS complex abnormal 28.32 10.53 15 93806 268 29858389
Cholestasis 28.28 10.53 22 93799 24928 29833729
Bundle branch block left 28.20 10.53 55 93766 5149 29853508
Sinus arrest 28.16 10.53 29 93792 1491 29857166
Nodal rhythm 27.92 10.53 28 93793 1395 29857262
Renal failure 27.00 10.53 560 93261 128406 29730251
Nodal arrhythmia 26.97 10.53 22 93799 835 29857822
Arrhythmia 26.84 10.53 187 93634 32982 29825675
Generalised tonic-clonic seizure 26.59 10.53 14 93807 19537 29839120
Alanine aminotransferase increased 26.47 10.53 131 93690 74145 29784512
Shock 26.18 10.53 141 93680 22718 29835939
Ventricular fibrillation 25.91 10.53 105 93716 15033 29843624
Sudden cardiac death 25.84 10.53 44 93777 3708 29854949
Oxygen saturation increased 25.76 10.53 13 93808 209 29858448
Pulmonary arterial pressure abnormal 25.26 10.53 12 93809 168 29858489
Infusion related reaction 25.21 10.53 56 93765 40508 29818149
Blood glucose decreased 25.16 10.53 94 93727 12959 29845698
Lower respiratory tract infection 25.04 10.53 28 93793 26686 29831971
Arthralgia 24.75 10.53 289 93532 135502 29723155
Rash maculo-papular 24.54 10.53 26 93795 25392 29833265
Blood pressure inadequately controlled 24.49 10.53 35 93786 2535 29856122
Oedema peripheral 24.30 10.53 466 93355 105366 29753291
Haemorrhage intracranial 23.95 10.53 102 93719 14930 29843727
Pancytopenia 23.88 10.53 162 93659 84890 29773767
Thrombocytopenia 23.71 10.53 295 93526 136749 29721908
Blood urea increased 23.69 10.53 174 93647 31207 29827450
Seizure 23.65 10.53 196 93625 98279 29760378
Pulmonary hypertension 23.57 10.53 120 93701 18916 29839741
Orthostatic hypotension 23.57 10.53 142 93679 23837 29834820
Hypertensive crisis 23.10 10.53 68 93753 8289 29850368
Cytomegalovirus infection 23.09 10.53 24 93797 23650 29835007
Rash 23.02 10.53 443 93378 191446 29667211
End stage renal disease 22.99 10.53 63 93758 7372 29851285
Neutrophil count decreased 22.94 10.53 63 93758 42391 29816266
Agranulocytosis 22.84 10.53 21 93800 21921 29836736
Ventricular internal diameter abnormal 22.74 10.53 8 93813 48 29858609
Fluid overload 22.70 10.53 119 93702 18973 29839684
Oesophageal discomfort 22.46 10.53 8 93813 50 29858607
Tricuspid valve incompetence 21.80 10.53 68 93753 8555 29850102
Jugular vein distension 21.65 10.53 16 93805 524 29858133
Full blood count decreased 21.55 10.53 102 93719 15615 29843042
Osteonecrosis 21.29 10.53 12 93809 16123 29842534
Drug resistance 21.28 10.53 19 93802 20114 29838543
Coma 21.14 10.53 61 93760 40388 29818269
Conjunctival scar 21.00 10.53 8 93813 62 29858595
C-reactive protein increased 20.98 10.53 68 93753 43405 29815252
Candida infection 20.89 10.53 11 93810 15351 29843306
Blood glucose increased 20.86 10.53 289 93532 61241 29797416
Neutrophil count increased 20.80 10.53 11 93810 15312 29843345
Angina unstable 20.76 10.53 85 93736 12225 29846432
Drug withdrawal syndrome 20.57 10.53 19 93802 19790 29838867
Suspected suicide 20.38 10.53 36 93785 3125 29855532
Bundle branch block 20.27 10.53 19 93802 870 29857787
Neuroleptic malignant syndrome 20.27 10.53 13 93808 16282 29842375
Epilepsy 20.18 10.53 20 93801 20149 29838508
Eosinophilia 19.94 10.53 24 93797 22136 29836521
Sinus bradycardia 19.92 10.53 81 93740 11614 29847043
Gingival hypertrophy 19.78 10.53 25 93796 1608 29857049
Cerebral infarction 19.78 10.53 146 93675 26227 29832430
Psychotic disorder 19.68 10.53 23 93798 21492 29837165
Graft versus host disease 19.51 10.53 4 93817 10146 29848511
Upper gastrointestinal haemorrhage 19.50 10.53 127 93694 21901 29836756
Bone marrow failure 19.44 10.53 40 93781 29745 29828912
Diastolic dysfunction 19.43 10.53 42 93779 4229 29854428
Cardiac pacemaker insertion 19.08 10.53 31 93790 2514 29856143
Abnormal behaviour 18.85 10.53 32 93789 25591 29833066
Immune reconstitution inflammatory syndrome 18.76 10.53 3 93818 9098 29849559
Nephrogenic anaemia 18.75 10.53 28 93793 2111 29856546
Fall 18.64 10.53 721 93100 181151 29677506
Dyspnoea exertional 18.54 10.53 181 93640 35249 29823408
Musculoskeletal stiffness 18.10 10.53 55 93766 35826 29822831
Overdose 17.98 10.53 173 93648 84164 29774493
Bronchopulmonary aspergillosis 17.92 10.53 8 93813 12276 29846381
Injection site pain 17.90 10.53 43 93778 30267 29828390
Sedation 17.85 10.53 15 93806 16358 29842299
Erythema 17.76 10.53 156 93665 77295 29781362
Serotonin syndrome 17.61 10.53 18 93803 17873 29840784
Torsade de pointes 17.54 10.53 56 93765 7134 29851523
Periodontitis 17.39 10.53 24 93797 1683 29856974
Implantable defibrillator insertion 17.38 10.53 16 93805 716 29857941
Neutropenic sepsis 17.33 10.53 7 93814 11402 29847255
Hepatitis 17.30 10.53 27 93794 22329 29836328
Atrioventricular block complete 17.14 10.53 62 93759 8415 29850242
Lymphopenia 17.07 10.53 10 93811 13153 29845504
Atrioventricular block second degree 16.79 10.53 33 93788 3107 29855550
Pulmonary renal syndrome 16.78 10.53 9 93812 165 29858492
Intentional self-injury 16.55 10.53 11 93810 13521 29845136
Schizophrenia 16.51 10.53 4 93817 9044 29849613
Brain natriuretic peptide increased 16.47 10.53 38 93783 3997 29854660
Progressive multifocal leukoencephalopathy 16.42 10.53 4 93817 9009 29849648
Arterial spasm 16.35 10.53 8 93813 120 29858537
Left atrial dilatation 16.29 10.53 24 93797 1787 29856870
Therapeutic product effect incomplete 16.27 10.53 53 93768 33781 29824876
Cardio-respiratory arrest 16.24 10.53 261 93560 57045 29801612
Tachycardia induced cardiomyopathy 16.15 10.53 7 93814 78 29858579
Oedema 15.84 10.53 205 93616 42788 29815869
Gallbladder oedema 15.70 10.53 9 93812 189 29858468
Lymphadenopathy 15.68 10.53 33 93788 24343 29834314
Vascular graft 15.64 10.53 21 93800 1434 29857223
Concomitant disease progression 15.35 10.53 28 93793 2492 29856165
Shunt occlusion 15.25 10.53 14 93807 624 29858033
Infective pulmonary exacerbation of cystic fibrosis 15.24 10.53 4 93817 8568 29850089
Pulmonary arterial pressure increased 15.15 10.53 18 93803 1086 29857571
Cardioversion 15.11 10.53 16 93805 850 29857807
Hallucination 15.01 10.53 91 93730 48968 29809689
Hypovolaemia 14.97 10.53 60 93761 8545 29850112
Haemophagocytic lymphohistiocytosis 14.88 10.53 6 93815 9785 29848872
Aspartate aminotransferase increased 14.87 10.53 127 93694 63295 29795362
Vomiting 14.86 10.53 551 93270 219267 29639390
Pathogen resistance 14.81 10.53 4 93817 8406 29850251
Subdural haematoma 14.78 10.53 106 93715 18866 29839791
Pulmonary embolism 14.72 10.53 165 93656 77970 29780687
Death 14.68 10.53 1304 92517 355979 29502678
Embolic stroke 14.67 10.53 34 93787 3588 29855069
Respiratory depression 14.55 10.53 9 93812 11494 29847163
Liver palpable 14.50 10.53 6 93815 59 29858598
Cerebral haemorrhage 14.38 10.53 162 93659 32725 29825932
Aspergillus infection 14.36 10.53 7 93814 10207 29848450
Intentional product use issue 14.32 10.53 62 93759 36378 29822279
Pulse waveform abnormal 14.31 10.53 3 93818 0 29858657
Cardioactive drug level above therapeutic 14.24 10.53 6 93815 62 29858595
Gastrointestinal endoscopic therapy 14.10 10.53 4 93817 10 29858647
Osteonecrosis of jaw 13.93 10.53 23 93798 18595 29840062
Pneumocystis jirovecii pneumonia 13.91 10.53 20 93801 17100 29841557
Left ventricular dysfunction 13.86 10.53 59 93762 8632 29850025
Symblepharon 13.85 10.53 7 93814 113 29858544
Gravitational oedema 13.84 10.53 13 93808 597 29858060
Tumour lysis syndrome 13.81 10.53 12 93809 12873 29845784
Myocardial ischaemia 13.63 10.53 97 93724 17220 29841437
Anti-neutrophil cytoplasmic antibody positive vasculitis 13.61 10.53 13 93808 610 29858047
Conduction disorder 13.60 10.53 23 93798 1928 29856729
Drug hypersensitivity 13.59 10.53 143 93678 68376 29790281
Acute pulmonary oedema 13.56 10.53 53 93768 7462 29851195
Tremor 13.48 10.53 161 93660 75202 29783455
Urticaria 13.41 10.53 108 93713 54498 29804159
Ventricular extrasystoles 13.29 10.53 71 93750 11403 29847254
Cardiac aneurysm 13.21 10.53 13 93808 633 29858024
Cerebellar haemorrhage 13.20 10.53 19 93802 1385 29857272
Heart rate abnormal 13.19 10.53 20 93801 1528 29857129
Substance abuse 13.07 10.53 3 93818 7037 29851620
Dyspnoea paroxysmal nocturnal 12.81 10.53 17 93804 1148 29857509
Extrapyramidal disorder 12.67 10.53 9 93812 10684 29847973
Cholangitis sclerosing 12.63 10.53 15 93806 905 29857752
Disturbance in attention 12.59 10.53 32 93789 22097 29836560
Dizziness postural 12.53 10.53 42 93779 5488 29853169
Arteriosclerosis 12.52 10.53 67 93754 10766 29847891
Confusional state 12.51 10.53 324 93497 134510 29724147
Human ehrlichiosis 12.51 10.53 8 93813 206 29858451
Mouth ulceration 12.48 10.53 9 93812 10600 29848057
Cardiac dysfunction 12.45 10.53 17 93804 1180 29857477
Thyroiditis 12.42 10.53 20 93801 1609 29857048
Hypoglycaemic unconsciousness 12.37 10.53 14 93807 802 29857855
Anger 12.36 10.53 10 93811 11110 29847547
Oral candidiasis 12.25 10.53 10 93811 11061 29847596
Internal haemorrhage 12.24 10.53 36 93785 4386 29854271
Dilatation atrial 12.22 10.53 23 93798 2096 29856561
Intracardiac thrombus 12.22 10.53 25 93796 2423 29856234
Chronic left ventricular failure 12.20 10.53 10 93811 382 29858275
Asthma 12.20 10.53 65 93756 36109 29822548
Epstein-Barr virus infection 12.17 10.53 3 93818 6703 29851954
Hydrothorax 12.16 10.53 11 93810 481 29858176
Toxic skin eruption 12.12 10.53 10 93811 11005 29847652
Ejection fraction abnormal 12.04 10.53 13 93808 706 29857951
Troponin I increased 11.98 10.53 21 93800 1812 29856845
Chills 11.65 10.53 158 93663 72180 29786477
Cogwheel rigidity 11.61 10.53 16 93805 1120 29857537
Cardiac output decreased 11.61 10.53 14 93807 858 29857799
Colitis ulcerative 11.59 10.53 17 93804 14417 29844240
Ventricular dyskinesia 11.57 10.53 7 93814 163 29858494
Coronary artery occlusion 11.56 10.53 67 93754 11090 29847567
Peripheral arterial occlusive disease 11.48 10.53 39 93782 5129 29853528
Eczema 11.48 10.53 15 93806 13354 29845303
Toxic goitre 11.38 10.53 3 93818 5 29858652
Lower gastrointestinal haemorrhage 11.35 10.53 52 93769 7852 29850805
Procedural hypotension 11.34 10.53 15 93806 1010 29857647
Haematochezia 11.29 10.53 160 93661 34062 29824595
Melaena 11.25 10.53 153 93668 32284 29826373
Inspiratory capacity decreased 11.19 10.53 6 93815 110 29858547
Periorbital haemorrhage 11.19 10.53 6 93815 110 29858547
Haemorrhagic cerebral infarction 11.09 10.53 13 93808 773 29857884
Incarcerated hernia 11.06 10.53 7 93814 177 29858480
Fatigue 11.02 10.53 1156 92665 319517 29539140
Atrioventricular block first degree 10.99 10.53 41 93780 5647 29853010
Peritonitis bacterial 10.94 10.53 67 93754 11311 29847346
Loss of personal independence in daily activities 10.87 10.53 33 93788 21502 29837155
Gout 10.86 10.53 92 93729 17223 29841434
Posterior reversible encephalopathy syndrome 10.76 10.53 7 93814 8700 29849957
Breath odour 10.71 10.53 13 93808 802 29857855
Dilatation ventricular 10.68 10.53 25 93796 2655 29856002
Blood pressure increased 10.67 10.53 298 93523 71630 29787027
Dyskinesia 10.64 10.53 34 93787 21800 29836857
Jaundice 10.61 10.53 59 93762 32427 29826230
Bronchostenosis 10.59 10.53 8 93813 271 29858386
Goitre 10.56 10.53 18 93803 1518 29857139
Acute generalised exanthematous pustulosis 10.55 10.53 3 93818 6095 29852562

Pharmacologic Action:

SourceCodeDescription
ATC C07AG02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Alpha and beta blocking agents
ATC C07FX06 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000099 Adrenergic alpha-Antagonists
FDA MoA N0000009923 Adrenergic beta1-Antagonists
FDA MoA N0000009924 Adrenergic beta2-Antagonists
FDA EPC N0000175553 alpha-Adrenergic Blocker
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018663 Adrenergic Agents
MeSH PA D058668 Adrenergic alpha-1 Receptor Antagonists
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D000975 Antioxidants
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D020011 Protective Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35530 beta-adrenoceptor antagonists
CHEBI has role CHEBI:35554 cardiovascular drugs
CHEBI has role CHEBI:35620 vasodilator
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:37890 alpha-adrenoceptor antagonists

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Left ventricular cardiac dysfunction indication 429589006
Atrial fibrillation off-label use 49436004 DOID:0060224
Diastolic heart failure off-label use 418304008 DOID:9775
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Bronchospasm contraindication 4386001
Complete atrioventricular block contraindication 27885002
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Low blood pressure contraindication 45007003
Sinus bradycardia contraindication 49710005
Hepatic failure contraindication 59927004
Chronic bronchitis contraindication 63480004 DOID:6132
Diabetes mellitus contraindication 73211009 DOID:9351
Prinzmetal angina contraindication 87343002
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Second degree atrioventricular block contraindication 195042002
Asthma contraindication 195967001 DOID:2841
Pregnancy, function contraindication 289908002
Peripheral vascular disease contraindication 400047006
Intraoperative floppy iris syndrome contraindication 418801006
Acutely Decompensated HF Requiring Parenteral Inotropic Therapy contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.13 acidic
pKa2 7.88 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 9.90 IUPHAR CHEMBL
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 9.50 IUPHAR CHEMBL
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 9.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 6.13 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 7.31 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 7.40 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 6.93 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 6.27 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 8.48 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.93 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 7.82 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 7.22 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 6.15 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 7.37 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.71 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 7.89 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 6.17 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 9.05 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR ANTAGONIST Ki 8.66 WOMBAT-PK
Solute carrier family 22 member 2 Transporter IC50 5.12 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.46 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 4.03 CHEMBL
Amyloid beta A4 protein Unclassified IC50 4.52 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 6.74 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 8.71 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 6.23 DRUG MATRIX
Beta-1 adrenergic receptor GPCR Ki 9.09 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 8.50 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 8.11 CHEMBL

External reference:

IDSource
4021041 VUID
N0000148505 NUI
D00255 KEGG_DRUG
374779-41-6 SECONDARY_CAS_RN
4021041 VANDF
4026028 VANDF
C0054836 UMLSCUI
CHEBI:3441 CHEBI
CVD PDB_CHEM_ID
CHEMBL723 ChEMBL_ID
CHEMBL1201167 ChEMBL_ID
DB01136 DRUGBANK_ID
D000077261 MESH_DESCRIPTOR_UI
5333 INN_ID
2585 PUBCHEM_CID
551 IUPHAR_LIGAND_ID
0K47UL67F2 UNII
20352 RXNORM
119032 MMSL
22339 MMSL
265288 MMSL
4363 MMSL
d03847 MMSL
004167 NDDF
011844 NDDF
108551001 SNOMEDCT_US
386870007 SNOMEDCT_US
426471008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
COREG HUMAN PRESCRIPTION DRUG LABEL 1 0007-4139 TABLET, FILM COATED 3.13 mg ORAL NDA 26 sections
COREG HUMAN PRESCRIPTION DRUG LABEL 1 0007-4140 TABLET, FILM COATED 6.25 mg ORAL NDA 26 sections
COREG HUMAN PRESCRIPTION DRUG LABEL 1 0007-4141 TABLET, FILM COATED 12.50 mg ORAL NDA 26 sections
COREG HUMAN PRESCRIPTION DRUG LABEL 1 0007-4142 TABLET, FILM COATED 25 mg ORAL NDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0051 TABLET, FILM COATED 3.13 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0135 TABLET, FILM COATED 6.25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7295 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7296 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0378-3631 TABLET, FILM COATED 3.13 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0378-3632 TABLET, FILM COATED 6.25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0378-3633 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0378-3634 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-7944 TABLET, FILM COATED 3.13 mg ORAL ANDA 27 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-7945 TABLET, FILM COATED 12.50 mg ORAL ANDA 27 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-7946 TABLET, FILM COATED 25 mg ORAL ANDA 27 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8018 TABLET, FILM COATED 6.25 mg ORAL ANDA 27 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8387 TABLET, FILM COATED 3.13 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8388 TABLET, FILM COATED 6.25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8389 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8390 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5221 TABLET, FILM COATED 3.13 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5222 TABLET, FILM COATED 6.25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5223 TABLET, FILM COATED 12.50 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5224 TABLET, FILM COATED 25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6300 TABLET, FILM COATED 3.13 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6301 TABLET, FILM COATED 6.25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6302 TABLET, FILM COATED 12.50 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6303 TABLET, FILM COATED 25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 10135-633 TABLET 3.13 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 10135-634 TABLET 6.25 mg ORAL ANDA 25 sections