pravastatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 2239 81093-37-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pravastatin
  • eptastatin
  • mevalothin
  • pravastatin acid
  • pravastatin sodium
  • pravachol
An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).
  • Molecular weight: 424.53
  • Formula: C23H36O7
  • CLOGP: 2.05
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 124.29
  • ALOGS: -3.24
  • ROTB: 11
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.57 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
S (Water solubility) 300 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 47 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 18 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.46 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 14 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.78 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.247 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.312 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 3.972 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 3.327 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 55.620 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 51.960 % High 1
herg hERG pIC50 4.533 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.972 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.483 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 52.880 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1 21
kinase-selectivity-class AXL,GRK2,MAP2K6,TGFBR1 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.400 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.977 High 1
mh-clint Mouse hepatocyte intrinsic clearance 26.002 High 1
mppb Mouse plasma protein binding (% unbound) 54.310 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 3.811 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 46.040 % High 1
rat-kpuu-brain Rat brain Kpuu 0.036 % High 1
rh-clint Rat hepatocyte intrinsic clearance 22.233 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 86.400 % High 1
rppb Rat plasma protein binding (% unbound) 48.040 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 901.571 uM High 1

Approvals:

DateAgencyCompanyOrphan
Oct. 31, 1991 FDA BRISTOL MYERS SQUIBB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 361.74 10.44 516 60991 174609 90392331
Hand deformity 185.84 10.44 3 61504 296359 90270581
Acute kidney injury 183.44 10.44 555 60952 319832 90247108
Systemic lupus erythematosus 173.38 10.44 21 61486 361875 90205065
Glossodynia 160.90 10.44 16 61491 321763 90245177
Synovitis 146.54 10.44 24 61483 329728 90237212
Contraindicated product administered 145.20 10.44 22 61485 320117 90246823
Pericarditis 144.50 10.44 10 61497 270141 90296799
Helicobacter infection 135.54 10.44 4 61503 226846 90340094
Duodenal ulcer perforation 128.34 10.44 5 61502 221283 90345657
Wound 128.21 10.44 25 61482 302955 90263985
Infusion related reaction 124.14 10.44 64 61443 416716 90150224
Maternal exposure during pregnancy 120.20 10.44 47 61460 360016 90206924
Folliculitis 117.22 10.44 5 61502 204348 90362592
Lower respiratory tract infection 116.49 10.44 16 61491 250643 90316297
Product dose omission issue 113.91 10.44 445 61062 291242 90275698
Treatment failure 109.42 10.44 35 61472 303893 90263047
Fall 103.72 10.44 619 60888 481191 90085749
Impaired healing 91.63 10.44 23 61484 234176 90332764
Arthropathy 88.85 10.44 71 61436 366171 90200769
Swelling 80.16 10.44 100 61407 418958 90147982
Hyperkalaemia 77.84 10.44 150 61357 64814 90502126
Lactic acidosis 73.76 10.44 127 61380 50336 90516604
Exposure during pregnancy 73.35 10.44 35 61472 238375 90328565
Hepatic enzyme increased 72.26 10.44 83 61424 360653 90206287
Diarrhoea 72.24 10.44 962 60545 938228 89628712
Atrioventricular block second degree 66.36 10.44 40 61467 4412 90562528
Muscle injury 65.97 10.44 19 61488 176635 90390305
Ill-defined disorder 65.26 10.44 22 61485 184869 90382071
Fibromyalgia 62.35 10.44 31 61476 206238 90360702
Type 2 diabetes mellitus 62.26 10.44 30 61477 203214 90363726
Discomfort 60.67 10.44 58 61449 274277 90292663
Drug ineffective 59.74 10.44 627 60880 1383671 89183269
Chronic kidney disease 59.04 10.44 115 61392 50076 90516864
Blister 58.66 10.44 52 61455 254946 90311994
Irritable bowel syndrome 57.16 10.44 35 61472 207413 90359527
Joint swelling 54.61 10.44 168 61339 503132 90063808
Myopathy 54.49 10.44 56 61451 13462 90553478
Therapeutic product effect decreased 54.34 10.44 65 61442 277506 90289434
Bursitis 51.34 10.44 13 61494 131641 90435299
Liver injury 51.00 10.44 26 61481 170541 90396399
Hyponatraemia 50.63 10.44 202 61305 133336 90433604
Colitis microscopic 50.08 10.44 49 61458 11110 90555830
Drug intolerance 49.55 10.44 148 61359 447443 90119497
Gastrointestinal disorder 49.30 10.44 61 61446 256626 90310314
Pulseless electrical activity 49.29 10.44 44 61463 8888 90558052
Atrial fibrillation 48.19 10.44 199 61308 133412 90433528
Lip dry 47.94 10.44 6 61501 100949 90465991
Full blood count decreased 47.75 10.44 78 61429 29611 90537329
Blood glucose increased 47.03 10.44 157 61350 95089 90471851
Injury 46.89 10.44 39 61468 197310 90369630
Alopecia 43.22 10.44 181 61326 494890 90072050
Drug interaction 43.00 10.44 328 61179 276125 90290815
Inflammation 42.79 10.44 35 61472 178557 90388383
Abdominal discomfort 42.61 10.44 173 61334 477155 90089785
Musculoskeletal stiffness 42.24 10.44 86 61421 296446 90270494
BRASH syndrome 41.93 10.44 22 61485 1857 90565083
Mobility decreased 41.75 10.44 66 61441 250668 90316272
Infection 41.31 10.44 118 61389 361976 90204964
Urinary tract infection 40.70 10.44 350 61157 305282 90261658
Immune-mediated myositis 39.34 10.44 23 61484 2398 90564542
Insulin autoimmune syndrome 39.25 10.44 11 61496 159 90566781
Joint range of motion decreased 38.61 10.44 22 61485 135621 90431319
Decreased bronchial secretion 38.12 10.44 9 61498 62 90566878
Rhabdomyolysis 37.29 10.44 97 61410 51159 90515781
Hypersensitivity 36.79 10.44 171 61336 454506 90112434
Bezoar 36.76 10.44 23 61484 2711 90564229
Muscle spasms 36.49 10.44 294 61213 251589 90315351
Psoriatic arthropathy 36.24 10.44 62 61445 228273 90338667
Congenital coronary artery malformation 35.40 10.44 10 61497 149 90566791
General physical health deterioration 34.05 10.44 125 61382 354990 90211950
Urinary incontinence 33.63 10.44 77 61430 37489 90529451
Blood thyroid stimulating hormone normal 33.21 10.44 9 61498 114 90566826
Autoimmune disorder 33.14 10.44 6 61501 76738 90490202
Wheezing 33.09 10.44 70 61437 238010 90328930
Pulmonary fibrosis 32.71 10.44 16 61491 107487 90459453
Grip strength decreased 32.68 10.44 11 61496 92565 90474375
Interstitial lung disease 32.58 10.44 120 61387 76285 90490655
Red blood cell sedimentation rate increased 32.50 10.44 8 61499 82587 90484353
Anaemia 32.38 10.44 374 61133 352428 90214512
Prescribed overdose 32.11 10.44 13 61494 97612 90469328
Acute interstitial pneumonitis 31.73 10.44 14 61493 805 90566135
Vitamin B12 decreased 30.98 10.44 27 61480 5283 90561657
Tubulointerstitial nephritis 30.94 10.44 59 61448 25284 90541656
Rheumatoid arthritis 30.74 10.44 134 61373 362480 90204460
Drug abuse 30.47 10.44 9 61498 82338 90484602
Vaccination site pain 30.24 10.44 11 61496 380 90566560
Vertigo 30.06 10.44 110 61397 69701 90497239
Pancreatitis acute 30.05 10.44 67 61440 32048 90534892
Peripheral venous disease 29.58 10.44 10 61497 83911 90483029
Cardiac failure congestive 28.78 10.44 138 61369 98556 90468384
Loss of consciousness 28.67 10.44 178 61329 140060 90426880
Live birth 28.63 10.44 9 61498 79098 90487842
Back pain 28.54 10.44 335 61172 316840 90250100
Haematoma 28.51 10.44 74 61433 38974 90527966
Wound infection 27.87 10.44 19 61488 106383 90460557
Cerebral haemorrhage 26.84 10.44 67 61440 34455 90532485
Product use issue 26.71 10.44 124 61383 329795 90237145
Allergic sinusitis 26.47 10.44 17 61490 2096 90564844
Hypercholesterolaemia 26.44 10.44 18 61489 100874 90466066
Renal disorder 25.87 10.44 70 61437 37789 90529151
Bone erosion 25.54 10.44 3 61504 53018 90513922
Off label use 25.34 10.44 563 60944 1101689 89465251
Hip arthroplasty 25.30 10.44 10 61497 76198 90490742
Diabetic ketoacidosis 25.22 10.44 53 61454 24354 90542586
Obesity 24.87 10.44 21 61486 105486 90461454
Asthenia 24.86 10.44 504 61003 533247 90033693
Electrocardiogram PR prolongation 24.73 10.44 12 61495 858 90566082
Feeling abnormal 24.63 10.44 196 61311 167039 90399901
Cerebral infarction 24.34 10.44 55 61452 26541 90540399
Cough 24.20 10.44 368 61139 368594 90198346
Gastrointestinal haemorrhage 24.04 10.44 123 61384 90125 90476815
Pain in extremity 23.90 10.44 434 61073 450095 90116845
Atrioventricular block first degree 23.57 10.44 29 61478 8482 90558458
Restless legs syndrome 23.46 10.44 49 61458 22421 90544519
Priapism 23.44 10.44 7 61500 128 90566812
Psoriasis 23.33 10.44 176 61331 147578 90419362
Transient ischaemic attack 22.95 10.44 73 61434 43103 90523837
Post viral fatigue syndrome 22.60 10.44 8 61499 255 90566685
Glycosylated haemoglobin increased 22.52 10.44 39 61468 15523 90551417
Nasal congestion 22.44 10.44 114 61393 83300 90483640
Stomatitis 22.37 10.44 103 61404 274595 90292345
Night sweats 22.28 10.44 33 61474 128733 90438207
Dysgeusia 21.94 10.44 82 61425 52478 90514462
Foreign body sensation in eyes 21.76 10.44 18 61489 3282 90563658
Metabolic acidosis 21.72 10.44 85 61422 55591 90511349
Therapeutic product effect incomplete 21.50 10.44 64 61443 193832 90373108
C-reactive protein increased 21.49 10.44 58 61449 181331 90385609
Axonal neuropathy 21.01 10.44 12 61495 1197 90565743
Blood uric acid increased 20.94 10.44 26 61481 7678 90559262
Therapy non-responder 20.88 10.44 38 61469 136666 90430274
Constipation 20.48 10.44 285 61222 280110 90286830
Muscle rupture 20.43 10.44 17 61490 3124 90563816
Human ehrlichiosis 20.40 10.44 7 61500 203 90566737
Decreased appetite 20.05 10.44 363 61144 376177 90190763
Diabetes mellitus 19.85 10.44 92 61415 64783 90502157
COVID-19 19.71 10.44 188 61319 168655 90398285
Blood loss anaemia 19.60 10.44 29 61478 10111 90556829
Melaena 19.57 10.44 60 61447 34737 90532203
Myelosuppression 19.57 10.44 6 61501 53585 90513355
Lower gastrointestinal haemorrhage 19.49 10.44 27 61480 8865 90558075
Intertrigo 19.44 10.44 10 61497 810 90566130
Dizziness 19.31 10.44 530 60977 588754 89978186
Sinus node dysfunction 19.29 10.44 21 61486 5391 90561549
Sinus arrhythmia 19.00 10.44 12 61495 1437 90565503
Cholestasis 18.96 10.44 61 61446 36238 90530702
Lower limb fracture 18.74 10.44 18 61489 84995 90481945
Inappropriate antidiuretic hormone secretion 18.60 10.44 41 61466 19464 90547476
Synovial disorder 18.49 10.44 16 61491 3102 90563838
Influenza 18.25 10.44 159 61348 139105 90427835
Postictal paralysis 18.22 10.44 7 61500 282 90566658
Renal tubular disorder 18.10 10.44 16 61491 3191 90563749
Device expulsion 18.08 10.44 3 61504 40883 90526057
Alexithymia 18.05 10.44 5 61502 69 90566871
Coronary artery disease 18.01 10.44 57 61450 33566 90533374
Epistaxis 17.99 10.44 109 61398 85016 90481924
Tinnitus 17.79 10.44 67 61440 43035 90523905
Death 17.70 10.44 420 61087 456131 90110809
Syncope 17.67 10.44 152 61355 132511 90434429
Hypoacusis 17.55 10.44 50 61457 27800 90539140
Sciatica 17.52 10.44 26 61481 101356 90465584
Bradycardia 17.49 10.44 107 61400 83740 90483200
Iron deficiency anaemia 17.43 10.44 45 61462 23617 90543323
Hyperlipidaemia 17.32 10.44 44 61463 22872 90544068
Hepatocellular injury 17.29 10.44 51 61456 28907 90538033
Intentional product use issue 17.26 10.44 82 61425 216810 90350130
Polymyalgia rheumatica 17.20 10.44 19 61488 4958 90561982
Fixed eruption 17.07 10.44 12 61495 1718 90565222
Viral infection 16.78 10.44 64 61443 41350 90525590
Product dispensing error 16.78 10.44 30 61477 12243 90554697
Foot deformity 16.51 10.44 10 61497 59641 90507299
Cardiac failure 16.49 10.44 129 61378 109367 90457573
Angina pectoris 16.27 10.44 61 61446 39099 90527841
Prothrombin time shortened 16.23 10.44 13 61494 2265 90564675
Adenocarcinoma metastatic 16.03 10.44 6 61501 225 90566715
Scratch 15.97 10.44 26 61481 9840 90557100
Dry gangrene 15.68 10.44 8 61499 637 90566303
Cardiac murmur functional 15.62 10.44 4 61503 40 90566900
Ear haemorrhage 15.58 10.44 11 61496 1585 90565355
Dehydration 15.58 10.44 201 61306 194246 90372694
Rhinorrhoea 15.55 10.44 108 61399 88208 90478732
Cutaneous T-cell lymphoma 15.43 10.44 11 61496 1609 90565331
Therapy cessation 15.40 10.44 57 61450 36304 90530636
Palpitations 15.34 10.44 151 61356 136577 90430363
Bronchitis 15.31 10.44 165 61342 152762 90414178
Pancreatic steatosis 15.30 10.44 11 61496 1631 90565309
Epilepsy 15.28 10.44 20 61487 82186 90484754
Erythematotelangiectatic rosacea 15.28 10.44 5 61502 125 90566815
Leukocytosis 15.21 10.44 51 61456 30939 90536001
Gastric infection 15.17 10.44 16 61491 3964 90562976
Vessel puncture site bruise 15.14 10.44 7 61500 449 90566491
Dysmetria 15.12 10.44 8 61499 687 90566253
Tooth disorder 15.12 10.44 51 61456 31039 90535901
Mixed liver injury 15.02 10.44 22 61485 7601 90559339
Dyspnoea exertional 14.92 10.44 92 61415 72196 90494744
Malaise 14.90 10.44 511 60996 585475 89981465
Dermatitis atopic 14.65 10.44 42 61465 23430 90543510
COVID-19 immunisation 14.57 10.44 11 61496 1758 90565182
Hepatitis cholestatic 14.46 10.44 23 61484 8538 90558402
Poor dental condition 14.40 10.44 7 61500 503 90566437
Gait inability 14.38 10.44 51 61456 146405 90420535
Drug hypersensitivity 14.34 10.44 414 61093 463195 90103745
Delirium 14.23 10.44 31 61476 104328 90462612
Toxic encephalopathy 14.18 10.44 23 61484 8676 90558264
Eye irritation 14.17 10.44 53 61454 33925 90533015
Ligament rupture 14.16 10.44 15 61492 3733 90563207
Peptic ulcer 14.12 10.44 18 61489 5457 90561483
Cholestatic liver injury 14 10.44 15 61492 3782 90563158
Pericardial haemorrhage 13.99 10.44 11 61496 1865 90565075
Onychomycosis 13.98 10.44 4 61503 37372 90529568
Hypokalaemia 13.85 10.44 143 61364 130973 90435967
Mammogram abnormal 13.69 10.44 8 61499 833 90566107
Skin depigmentation 13.62 10.44 9 61498 1164 90565776
Renal impairment 13.62 10.44 120 61387 105301 90461639
Essential hypertension 13.58 10.44 19 61488 6296 90560644
Pulmonary renal syndrome 13.49 10.44 7 61500 578 90566362
Enteritis infectious 13.44 10.44 12 61495 2423 90564517
Atrioventricular block complete 13.43 10.44 24 61483 9787 90557153
Tremor 13.41 10.44 161 61346 153012 90413928
Bacteriuria 13.40 10.44 9 61498 1197 90565743
Trigger finger 13.34 10.44 17 61490 5153 90561787
Potassium wasting nephropathy 13.30 10.44 4 61503 75 90566865
Hypovolaemic shock 13.30 10.44 20 61487 7074 90559866
Arterial thrombosis 13.29 10.44 10 61497 1590 90565350
Myopathy toxic 13.17 10.44 7 61500 607 90566333
Ligament sprain 13.15 10.44 30 61477 14569 90552371
Subarachnoid haemorrhage 13.14 10.44 34 61473 17870 90549070
Blood cholesterol increased 13.08 10.44 85 61422 207927 90359013
Blood iron decreased 13.07 10.44 34 61473 17925 90549015
Clostridium difficile infection 13.07 10.44 54 61453 36191 90530749
Coeliac disease 13.03 10.44 7 61500 44603 90522337
Colitis ischaemic 12.98 10.44 27 61480 12319 90554621
Vision blurred 12.96 10.44 123 61384 110170 90456770
Lung disorder 12.92 10.44 55 61452 149828 90417112
Knee arthroplasty 12.81 10.44 23 61484 83159 90483781
Eye haemorrhage 12.80 10.44 24 61483 10156 90556784
Alanine aminotransferase 12.70 10.44 4 61503 88 90566852
Oxygen saturation decreased 12.70 10.44 120 61387 107363 90459577
Hypochloraemia 12.68 10.44 12 61495 2610 90564330
Low density lipoprotein increased 12.67 10.44 21 61486 8064 90558876
Eczema 12.67 10.44 70 61437 52800 90514140
Uterine dilation and evacuation 12.66 10.44 3 61504 21 90566919
Hypoglycaemia 12.64 10.44 86 61421 69762 90497178
Cataract 12.60 10.44 88 61419 72004 90494936
Orthostatic hypotension 12.56 10.44 59 61448 41768 90525172
Blood creatine phosphokinase increased 12.51 10.44 51 61456 33972 90532968
Seborrhoeic keratosis 12.50 10.44 13 61494 3167 90563773
Head injury 12.47 10.44 48 61459 31140 90535800
Angular cheilitis 12.41 10.44 8 61499 993 90565947
Suicide attempt 12.39 10.44 20 61487 75379 90491561
Encephalopathy 12.16 10.44 63 61444 46381 90520559
Renal cyst 12.10 10.44 27 61480 12923 90554017
Small fibre neuropathy 12.09 10.44 7 61500 717 90566223
Peak expiratory flow rate abnormal 12.04 10.44 4 61503 105 90566835
Illness 12.02 10.44 96 61411 81873 90485067
Haematoma muscle 12.01 10.44 10 61497 1840 90565100
Platelet count decreased 12.00 10.44 144 61363 136825 90430115
Cerebral mass effect 11.95 10.44 8 61499 1058 90565882
Glycosuria 11.95 10.44 9 61498 1433 90565507
Ocular retrobulbar haemorrhage 11.83 10.44 4 61503 111 90566829
Nausea 11.82 10.44 890 60617 1109426 89457514
Symptom recurrence 11.80 10.44 14 61493 3945 90562995
Nightmare 11.79 10.44 37 61470 21688 90545252
Liver function test increased 11.74 10.44 25 61482 84830 90482110
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.70 10.44 14 61493 3979 90562961
Pancytopenia 11.69 10.44 129 61378 120134 90446806
Low density lipoprotein decreased 11.63 10.44 5 61502 270 90566670
Sinus congestion 11.63 10.44 43 61464 27381 90539559
Gastric ulcer 11.60 10.44 43 61464 27405 90539535
Fanconi syndrome 11.58 10.44 10 61497 1933 90565007
Adrenal insufficiency 11.57 10.44 3 61504 29918 90537022
Finger deformity 11.45 10.44 4 61503 32893 90534047
Heart rate abnormal 11.43 10.44 17 61490 5954 90560986
Upper-airway cough syndrome 11.37 10.44 29 61478 15106 90551834
Lipoma 11.37 10.44 12 61495 2974 90563966
Nail disorder 11.37 10.44 14 61493 59053 90507887
Hyperthermia 11.33 10.44 23 61484 10312 90556628
Back injury 11.33 10.44 9 61498 46613 90520327
Cerebrovascular accident 11.32 10.44 131 61376 123402 90443538
Left ventricular failure 11.31 10.44 18 61489 6682 90560258
Fatigue 11.30 10.44 919 60588 1153104 89413836
Hypersensitivity vasculitis 11.24 10.44 14 61493 4145 90562795
Immunosuppressant drug level decreased 11.24 10.44 8 61499 1168 90565772
Muscle discomfort 11.19 10.44 5 61502 296 90566644
Muscle spasticity 11.14 10.44 5 61502 35317 90531623
Plasma cell myeloma 11.12 10.44 56 61451 40772 90526168
Drug tolerance decreased 11.03 10.44 4 61503 32126 90534814
Blood glucose decreased 11.01 10.44 38 61469 23391 90543549
Blood triglycerides increased 11.01 10.44 27 61480 13734 90553206
Pyrexia 11.00 10.44 353 61154 660132 89906808
Sleep disorder 10.94 10.44 84 61423 197946 90368994
Limb discomfort 10.93 10.44 53 61454 38007 90528933
Skin test negative 10.93 10.44 3 61504 40 90566900
Paranasal sinus discomfort 10.93 10.44 17 61490 6193 90560747
Somnolence 10.91 10.44 201 61306 208883 90358057
Peripheral coldness 10.84 10.44 27 61480 13865 90553075
Pyuria 10.83 10.44 10 61497 2109 90564831
Acute abdomen 10.82 10.44 9 61498 1654 90565286
Dry skin 10.74 10.44 99 61408 87974 90478966
White blood cell count decreased 10.67 10.44 166 61341 166943 90399997
Hallucination 10.65 10.44 79 61428 65880 90501060
Arteriosclerosis 10.56 10.44 23 61484 10830 90556110
Throat clearing 10.48 10.44 13 61494 3834 90563106
Prescribed underdose 10.46 10.44 22 61485 74997 90491943

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 236.36 11.08 416 50331 95664 42474924
Burns second degree 105.13 11.08 74 50673 6022 42564566
Catarrh 104.01 11.08 73 50674 5913 42564675
Parosmia 100.44 11.08 79 50668 7612 42562976
Hypopnoea 96.61 11.08 78 50669 7804 42562784
Steroid dependence 96.42 11.08 73 50674 6649 42563939
Gingival pain 93.55 11.08 79 50668 8415 42562173
Systemic lupus erythematosus 89.14 11.08 80 50667 9244 42561344
Impaired work ability 85.76 11.08 88 50659 12003 42558585
Drug abuse 80.25 11.08 14 50733 104757 42465831
Dysgeusia 71.28 11.08 138 50609 34051 42536537
IgM nephropathy 70.49 11.08 19 50728 126 42570462
Rhinitis 68.84 11.08 78 50669 11899 42558689
Acute kidney injury 67.74 11.08 701 50046 366636 42203952
Cardiac murmur 66.40 11.08 79 50668 12696 42557892
Blood creatine phosphokinase increased 65.40 11.08 164 50583 48174 42522414
Alcohol poisoning 64.66 11.08 61 50686 7513 42563075
Eczema 64.35 11.08 132 50615 33954 42536634
Cerebrovascular accident 60.07 11.08 252 50495 96908 42473680
Swollen tongue 58.77 11.08 97 50650 21134 42549454
Vertigo 55.63 11.08 125 50622 34222 42536366
Impaired quality of life 52.28 11.08 74 50673 14103 42556485
Shone complex 50.23 11.08 13 50734 72 42570516
Rectal haemorrhage 48.95 11.08 150 50597 49456 42521132
Lactic acidosis 46.67 11.08 139 50608 45122 42525466
Tubulointerstitial nephritis 45.81 11.08 110 50637 31438 42539150
Bronchiectasis 45.47 11.08 79 50668 17940 42552648
Tinnitus 45.40 11.08 104 50643 28834 42541754
Febrile neutropenia 44.34 11.08 97 50650 185606 42384982
Drug ineffective 44.00 11.08 510 50237 629687 41940901
Nightmare 42.72 11.08 93 50654 24919 42545669
Gastritis fungal 38.36 11.08 12 50735 142 42570446
Myopathy 38.25 11.08 63 50684 13698 42556890
Frequent bowel movements 38.17 11.08 81 50666 21326 42549262
Colitis ulcerative 37.71 11.08 91 50656 26084 42544504
Migraine 37.31 11.08 89 50658 25325 42545263
Pericarditis fungal 37.18 11.08 13 50734 222 42570366
Fall 35.98 11.08 432 50315 234088 42336500
Accidental overdose 35.08 11.08 93 50654 28237 42542351
Loss of control of legs 34.85 11.08 18 50729 831 42569757
Angina pectoris 33.88 11.08 101 50646 32795 42537793
Puncture site haematoma 32.48 11.08 11 50736 170 42570418
Intraocular haematoma 32.47 11.08 7 50740 14 42570574
Treatment failure 32.46 11.08 17 50730 62607 42507981
Interstitial lung disease 32.21 11.08 181 50566 78281 42492307
Exercise lack of 31.99 11.08 10 50737 118 42570470
Supravalvular aortic stenosis 31.27 11.08 8 50739 42 42570546
Cholestasis 31.11 11.08 98 50649 32781 42537807
Abdominal discomfort 30.49 11.08 173 50574 75082 42495506
Intestinal atony 30.37 11.08 8 50739 48 42570540
Palpitations 30.01 11.08 130 50617 50667 42519921
Muscle rupture 29.59 11.08 24 50723 2416 42568172
Drug interaction 29.57 11.08 464 50283 266535 42304053
Off label use 29.39 11.08 560 50187 637775 41932813
Fatigue 29.16 11.08 701 50046 434940 42135648
Aorta hypoplasia 28.81 11.08 9 50738 106 42570482
Suicide attempt 27.88 11.08 10 50737 46090 42524498
Completed suicide 27.74 11.08 45 50702 96420 42474168
Disease progression 27.39 11.08 84 50663 143572 42427016
Meningitis fungal 27.09 11.08 10 50737 201 42570387
Toxicity to various agents 27.03 11.08 161 50586 228975 42341613
Diaphragmatic disorder 26.03 11.08 17 50730 1222 42569366
Foetal exposure during pregnancy 25.79 11.08 12 50735 47299 42523289
Muscle spasms 25.68 11.08 183 50564 85861 42484727
Congenital heart valve disorder 24.94 11.08 7 50740 55 42570533
Renal-limited thrombotic microangiopathy 24.55 11.08 10 50737 264 42570324
Hyperkinetic heart syndrome 23.84 11.08 8 50739 120 42570468
Phaeochromocytoma malignant 23.62 11.08 7 50740 68 42570520
Arthritis 23.59 11.08 106 50641 41959 42528629
Pemphigoid 23.54 11.08 46 50701 11421 42559167
Injection site hypersensitivity 23.40 11.08 11 50736 413 42570175
Adverse drug reaction 23.03 11.08 97 50650 37337 42533251
Sepsis 22.49 11.08 142 50605 199192 42371396
Tendon rupture 22.46 11.08 37 50710 8046 42562542
Necrotising myositis 22.39 11.08 15 50732 1126 42569462
Mitral valve hypoplasia 22.36 11.08 6 50741 39 42570549
Coma uraemic 22.11 11.08 6 50741 41 42570547
Vascular pseudoaneurysm 21.55 11.08 21 50726 2691 42567897
AST/ALT ratio abnormal 21.29 11.08 5 50742 17 42570571
Pseudolymphoma 21.08 11.08 12 50735 673 42569915
Rash 21.07 11.08 454 50293 276500 42294088
Rectal abscess 21.07 11.08 17 50730 1698 42568890
Hepatocellular injury 20.97 11.08 69 50678 23609 42546979
Nephrogenic anaemia 20.50 11.08 20 50727 2566 42568022
Thrombocytopenia 20.22 11.08 138 50609 190141 42380447
Pain in extremity 19.90 11.08 270 50477 150334 42420254
Multiple organ dysfunction syndrome 19.75 11.08 55 50692 96980 42473608
Toxic epidermal necrolysis 19.56 11.08 4 50743 26746 42543842
Coarctation of the aorta 19.29 11.08 10 50737 465 42570123
Neutropenia 19.09 11.08 149 50598 199282 42371306
Chest wall haematoma 19.01 11.08 8 50739 230 42570358
Rhabdomyolysis 18.86 11.08 158 50589 77861 42492727
Cerebral haematoma 18.81 11.08 28 50719 5582 42565006
Neutrophil count decreased 18.78 11.08 29 50718 63386 42507202
Congenital aortic anomaly 18.74 11.08 6 50741 77 42570511
Intraventricular haemorrhage 18.52 11.08 23 50724 3861 42566727
Gait disturbance 18.41 11.08 188 50559 97812 42472776
Drug resistance 18.19 11.08 9 50738 34239 42536349
Premature baby 17.92 11.08 3 50744 23150 42547438
Electrocardiogram ST segment depression 17.76 11.08 19 50728 2718 42567870
Left ventricular hypertrophy 17.47 11.08 36 50711 9283 42561305
Femoral artery aneurysm 17.22 11.08 7 50740 184 42570404
Myelosuppression 16.89 11.08 14 50733 40447 42530141
Subdural haematoma 16.67 11.08 63 50684 23075 42547513
Toxic optic neuropathy 16.49 11.08 12 50735 1028 42569560
Eosinophilic pleural effusion 16.30 11.08 8 50739 331 42570257
Carnitine palmitoyltransferase deficiency 15.96 11.08 4 50743 19 42570569
Peripheral swelling 15.93 11.08 171 50576 90099 42480489
Dependence on oxygen therapy 15.85 11.08 7 50740 227 42570361
Agitation 15.82 11.08 33 50714 64281 42506307
Lupus-like syndrome 15.56 11.08 19 50728 3135 42567453
Injection site discolouration 15.47 11.08 15 50732 1911 42568677
Medication error 15.30 11.08 79 50668 33075 42537513
Apolipoprotein increased 15.13 11.08 3 50744 3 42570585
Infusion related reaction 15.12 11.08 31 50716 60775 42509813
Congenital aortic valve stenosis 15 11.08 6 50741 151 42570437
Cell death 14.88 11.08 18 50729 2941 42567647
Thrombotic stroke 14.81 11.08 7 50740 266 42570322
Confusional state 14.80 11.08 281 50466 167316 42403272
Haemorrhagic transformation stroke 14.48 11.08 14 50733 1777 42568811
Heart transplant rejection 14.34 11.08 13 50734 1521 42569067
Intensive care unit acquired weakness 14.30 11.08 12 50735 1266 42569322
Weight decreased 14.26 11.08 336 50411 207612 42362976
Renal arteriosclerosis 14.05 11.08 7 50740 299 42570289
Akinesia 14.03 11.08 16 50731 2456 42568132
Hyperkalaemia 14.00 11.08 152 50595 80306 42490282
Myotonic dystrophy 13.96 11.08 6 50741 182 42570406
Congenital aortic stenosis 13.91 11.08 5 50742 93 42570495
Transaminases abnormal 13.84 11.08 7 50740 309 42570279
Drug ineffective for unapproved indication 13.77 11.08 21 50726 46142 42524446
Therapeutic drug monitoring analysis incorrectly performed 13.66 11.08 7 50740 318 42570270
Impatience 13.62 11.08 8 50739 476 42570112
Orthostatic tremor 13.60 11.08 3 50744 7 42570581
Disseminated mucormycosis 13.42 11.08 12 50735 1379 42569209
Sedation 13.40 11.08 10 50737 30465 42540123
Anti factor VIII antibody positive 13.30 11.08 5 50742 106 42570482
Arteriovenous fistula 13.27 11.08 11 50736 1141 42569447
Xerosis 13.25 11.08 10 50737 906 42569682
Lip discolouration 13.24 11.08 6 50741 207 42570381
Pancytopenia 13.20 11.08 84 50663 117659 42452929
Muscle discomfort 12.97 11.08 6 50741 217 42570371
Hypoparathyroidism 12.96 11.08 9 50738 716 42569872
Diarrhoea 12.86 11.08 671 50076 460178 42110410
Myocardial infarction 12.75 11.08 213 50534 123796 42446792
General physical health deterioration 12.67 11.08 117 50630 151129 42419459
Glycosylated haemoglobin increased 12.66 11.08 39 50708 12885 42557703
Loss of personal independence in daily activities 12.63 11.08 102 50645 49714 42520874
Bladder cyst 12.49 11.08 5 50742 126 42570462
Depression 12.46 11.08 194 50553 111169 42459419
Peripheral artery occlusion 12.42 11.08 13 50734 1813 42568775
Conjunctival haemorrhage 12.38 11.08 18 50729 3515 42567073
Drug eruption 12.08 11.08 57 50690 23018 42547570
Pleurisy 11.82 11.08 22 50725 5268 42565320
Vomiting 11.80 11.08 259 50488 289464 42281124
Acute respiratory failure 11.79 11.08 83 50664 38775 42531813
Low density lipoprotein increased 11.63 11.08 22 50725 5333 42565255
Heat stroke 11.58 11.08 10 50737 1098 42569490
Hepatitis fulminant 11.55 11.08 21 50726 4938 42565650
Product container seal issue 11.53 11.08 3 50744 17 42570571
Acquired haemophilia 11.53 11.08 12 50735 1663 42568925
Ketonuria 11.31 11.08 8 50739 656 42569932
Myoglobin urine 11.25 11.08 3 50744 19 42570569
Atrial hypertrophy 11.25 11.08 3 50744 19 42570569
Heart disease congenital 11.15 11.08 11 50736 1431 42569157
Blood urine present 11.12 11.08 35 50712 11698 42558890
Blood loss anaemia 11.09 11.08 31 50716 9705 42560883

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 469.60 10.21 759 96134 221622 110270784
Acute kidney injury 273.54 10.21 1191 95702 634239 109858167
Hand deformity 176.16 10.21 3 96890 218503 110273903
Synovitis 158.83 10.21 25 96868 274067 110218339
Glossodynia 141.24 10.21 15 96878 221989 110270417
Pericarditis 138.90 10.21 15 96878 219099 110273307
Infusion related reaction 138.55 10.21 81 96812 381081 110111325
Maternal exposure during pregnancy 131.30 10.21 31 96862 254852 110237554
Lactic acidosis 130.74 10.21 266 96627 92545 110399861
Catarrh 130.71 10.21 81 96812 7254 110485152
Duodenal ulcer perforation 130.27 10.21 6 96887 177694 110314712
Contraindicated product administered 128.27 10.21 30 96863 248237 110244169
Burns second degree 126.78 10.21 81 96812 7652 110484754
Helicobacter infection 124.60 10.21 9 96884 181868 110310538
Treatment failure 123.93 10.21 44 96849 277190 110215216
Fall 122.47 10.21 926 95967 602556 109889850
Steroid dependence 117.67 10.21 80 96813 8389 110484017
Folliculitis 115.71 10.21 8 96885 167645 110324761
Hypopnoea 111.47 10.21 87 96806 11293 110481113
Lower respiratory tract infection 106.26 10.21 40 96853 243066 110249340
Parosmia 104.33 10.21 89 96804 13091 110479315
Wound 103.43 10.21 38 96855 234399 110258007
Drug interaction 102.80 10.21 770 96123 499413 109992993
Gingival pain 94.55 10.21 91 96802 15645 110476761
Drug abuse 92.50 10.21 21 96872 177390 110315016
Hyperkalaemia 92.01 10.21 295 96598 135501 110356905
Arthropathy 91.17 10.21 71 96822 287451 110204955
Drug ineffective 90.48 10.21 875 96018 1519665 108972741
Dysgeusia 88.56 10.21 192 96701 69793 110422613
Exposure during pregnancy 86.92 10.21 20 96873 167404 110325002
Tubulointerstitial nephritis 86.64 10.21 164 96729 54120 110438286
Tinnitus 83.46 10.21 172 96721 60368 110432038
Eczema 83.24 10.21 191 96702 72102 110420304
Blood creatine phosphokinase increased 79.69 10.21 189 96704 72888 110419518
Swelling 79.63 10.21 115 96778 350926 110141480
Cerebrovascular accident 79.31 10.21 342 96551 180942 110311464
Myopathy 78.52 10.21 103 96790 24857 110467549
Fibromyalgia 78.30 10.21 26 96867 170883 110321523
Alcohol poisoning 77.79 10.21 64 96829 8956 110483450
Vertigo 77.31 10.21 208 96685 86662 110405744
Bursitis 77.18 10.21 11 96882 129907 110362499
IgM nephropathy 75.51 10.21 19 96874 132 110492274
Impaired healing 75.49 10.21 39 96854 196678 110295728
Joint swelling 73.10 10.21 176 96717 442669 110049737
Ill-defined disorder 71.61 10.21 24 96869 156829 110335577
Interstitial lung disease 71.35 10.21 276 96617 139058 110353348
Nightmare 70.36 10.21 124 96769 38739 110453667
Irritable bowel syndrome 68.50 10.21 29 96864 164186 110328220
Lip dry 68.40 10.21 5 96888 100078 110392328
Rhinitis 67.79 10.21 91 96802 22454 110469952
Muscle injury 67.04 10.21 20 96873 140787 110351619
Impaired work ability 65.16 10.21 97 96796 26322 110466084
Cardiac murmur 60.14 10.21 90 96803 24538 110467868
Therapeutic product effect decreased 59.46 10.21 76 96817 244240 110248166
Swollen tongue 59.31 10.21 150 96743 60212 110432194
Impaired quality of life 58.56 10.21 99 96794 29918 110462488
Inflammation 58.40 10.21 50 96843 193188 110299218
Cholestasis 57.93 10.21 155 96738 64363 110428043
Blister 57.14 10.21 69 96824 227307 110265099
Hepatic enzyme increased 55.77 10.21 124 96769 320768 110171638
Drug intolerance 54.87 10.21 178 96715 406334 110086072
Musculoskeletal stiffness 54.71 10.21 101 96792 279721 110212685
Rhabdomyolysis 54.07 10.21 229 96664 120172 110372234
Off label use 52.16 10.21 964 95929 1499221 108993185
Accidental overdose 50.08 10.21 128 96765 51706 110440700
Psoriatic arthropathy 49.13 10.21 60 96833 196701 110295705
Lipoprotein (a) decreased 48.79 10.21 11 96882 44 110492362
Diarrhoea 48.67 10.21 1324 95569 1138181 109354225
Alopecia 48.33 10.21 161 96732 364592 110127814
Mobility decreased 47.93 10.21 84 96809 237338 110255068
Gastrointestinal disorder 47.58 10.21 87 96806 241865 110250541
Injury 47.57 10.21 51 96842 177214 110315192
Hyponatraemia 47.42 10.21 340 96553 217313 110275093
Chronic kidney disease 47.42 10.21 161 96732 76130 110416276
Joint range of motion decreased 46.96 10.21 24 96869 121808 110370598
Hypersensitivity 46.52 10.21 189 96704 403809 110088597
Liver injury 45.34 10.21 39 96854 150374 110342032
Atrial fibrillation 44.53 10.21 349 96544 229293 110263113
Systemic lupus erythematosus 44.41 10.21 98 96795 254240 110238166
Type 2 diabetes mellitus 44.30 10.21 54 96839 177178 110315228
Therapy non-responder 43.63 10.21 44 96849 157263 110335143
Red blood cell sedimentation rate increased 43.43 10.21 8 96885 78294 110414112
Live birth 43.40 10.21 5 96888 69479 110422927
Bronchiectasis 42.65 10.21 97 96796 36396 110456010
Infection 42.61 10.21 168 96725 362032 110130374
Immune-mediated myositis 41.43 10.21 38 96855 6148 110486258
Atrioventricular block second degree 41.21 10.21 43 96850 8138 110484268
Wheezing 40.08 10.21 104 96789 255126 110237280
Peripheral venous disease 39.94 10.21 12 96881 84105 110408301
Hepatocellular injury 39.88 10.21 116 96777 50526 110441880
Rheumatoid arthritis 39.85 10.21 132 96761 299481 110192925
Pancreatitis acute 39.05 10.21 129 96764 60145 110432261
Product dose omission issue 38.81 10.21 442 96451 321340 110171066
Pericarditis fungal 37.40 10.21 13 96880 301 110492105
Grip strength decreased 37.06 10.21 12 96881 80162 110412244
Blepharospasm 36.75 10.21 3 96890 54848 110437558
General physical health deterioration 35.77 10.21 222 96671 425073 110067333
Myelosuppression 35.74 10.21 19 96874 94321 110398085
Discomfort 35.65 10.21 85 96808 214622 110277784
Decreased bronchial secretion 35.59 10.21 9 96884 64 110492342
Night sweats 35.45 10.21 39 96854 133944 110358462
Palpitations 35.42 10.21 250 96643 158962 110333444
Congenital coronary artery malformation 35.10 10.21 10 96883 117 110492289
Angina pectoris 34.86 10.21 127 96766 62168 110430238
Glycosylated haemoglobin increased 34.80 10.21 69 96824 23550 110468856
Loss of control of legs 34.13 10.21 22 96871 2110 110490296
Muscle spasms 33.50 10.21 382 96511 277775 110214631
Pemphigoid 33.27 10.21 61 96832 19646 110472760
Muscle rupture 33.04 10.21 29 96864 4431 110487975
Blood glucose increased 33.03 10.21 214 96679 132282 110360124
Gastritis fungal 33.00 10.21 12 96881 318 110492088
Full blood count decreased 32.82 10.21 81 96812 32018 110460388
Colitis microscopic 32.78 10.21 49 96844 13345 110479061
Cerebral haematoma 32.25 10.21 41 96852 9591 110482815
Suicide attempt 32.16 10.21 26 96867 103368 110389038
Intraocular haematoma 32.12 10.21 7 96886 23 110492383
Amaurosis fugax 31.84 10.21 22 96871 2368 110490038
Wound infection 31.60 10.21 23 96870 96442 110395964
COVID-19 31.54 10.21 341 96552 244719 110247687
Puncture site haematoma 31.31 10.21 11 96882 263 110492143
Subdural haematoma 31.14 10.21 86 96807 36368 110456038
Blood thyroid stimulating hormone normal 30.79 10.21 9 96884 116 110492290
Pain in extremity 30.65 10.21 598 96295 486520 110005886
Pulmonary fibrosis 30.10 10.21 27 96866 102015 110390391
Bone erosion 29.82 10.21 3 96890 46368 110446038
Product use issue 29.81 10.21 156 96737 311539 110180867
Cardiac failure congestive 29.54 10.21 230 96663 150770 110341636
Blood loss anaemia 29.43 10.21 55 96838 17970 110474436
Completed suicide 29.40 10.21 111 96782 242270 110250136
Haemorrhagic stroke 28.94 10.21 47 96846 13742 110478664
Haematoma 28.43 10.21 114 96779 58362 110434044
Febrile neutropenia 28.39 10.21 162 96731 316605 110175801
Pseudolymphoma 28.18 10.21 16 96877 1219 110491187
Sinusitis 28.09 10.21 149 96744 296539 110195867
Death 26.93 10.21 802 96091 698067 109794339
Obesity 26.80 10.21 36 96857 113315 110379091
Cerebral infarction 26.77 10.21 103 96790 51735 110440671
Autoimmune disorder 26.61 10.21 12 96881 65471 110426935
Sciatica 26.60 10.21 25 96868 92374 110400032
Stomatitis 26.55 10.21 134 96759 270108 110222298
Phaeochromocytoma malignant 25.75 10.21 7 96886 68 110492338
C-reactive protein increased 25.66 10.21 101 96792 217818 110274588
Shone complex 25.52 10.21 6 96887 30 110492376
Mitral valve hypoplasia 25.52 10.21 6 96887 30 110492376
Meningitis fungal 25.46 10.21 10 96883 329 110492077
Congenital aortic valve stenosis 25.36 10.21 6 96887 31 110492375
Hyperkinetic heart syndrome 25.11 10.21 8 96885 140 110492266
Gait disturbance 24.99 10.21 362 96531 277846 110214560
Aorta hypoplasia 24.89 10.21 6 96887 34 110492372
Urinary tract infection 24.53 10.21 412 96481 325870 110166536
Intraventricular haemorrhage 24.32 10.21 27 96866 5480 110486926
Diaphragmatic disorder 24.28 10.21 17 96876 1869 110490537
Rectal haemorrhage 24.26 10.21 184 96709 119649 110372757
Metabolic acidosis 24.18 10.21 160 96733 99584 110392822
Vaccination site pain 24.10 10.21 11 96882 528 110491878
Congenital heart valve disorder 24.06 10.21 6 96887 40 110492366
Coma uraemic 23.81 10.21 6 96887 42 110492364
Toxicity to various agents 23.38 10.21 289 96604 480266 110012140
BRASH syndrome 23.26 10.21 22 96871 3701 110488705
Heart transplant rejection 23.22 10.21 17 96876 2004 110490402
Foot deformity 22.86 10.21 7 96886 48473 110443933
Allergic sinusitis 22.80 10.21 16 96877 1765 110490641
Dermatitis atopic 22.56 10.21 61 96832 25480 110466926
Therapeutic product effect incomplete 21.96 10.21 111 96782 223694 110268712
Myocardial infarction 21.87 10.21 261 96632 191822 110300584
Tendon rupture 21.80 10.21 42 96851 14036 110478370
Bezoar 21.67 10.21 22 96871 4032 110488374
Intestinal atony 21.35 10.21 8 96885 231 110492175
Congenital aortic stenosis 21.27 10.21 5 96888 25 110492381
Congenital aortic anomaly 21.27 10.21 5 96888 25 110492381
Exercise lack of 21.25 10.21 10 96883 515 110491891
Pulseless electrical activity 21.22 10.21 46 96847 16711 110475695
Loss of consciousness 21.16 10.21 264 96629 196042 110296364
Coarctation of the aorta 21.15 10.21 6 96887 69 110492337
Insulin autoimmune syndrome 20.76 10.21 11 96882 731 110491675
Supravalvular aortic stenosis 20.65 10.21 5 96888 29 110492377
Epilepsy 20.62 10.21 35 96858 100174 110392232
Deep vein thrombosis 20.53 10.21 200 96693 139687 110352719
Hepatic cytolysis 20.43 10.21 99 96794 54954 110437452
Melaena 20.26 10.21 116 96777 68641 110423765
Drug ineffective for unapproved indication 20.19 10.21 37 96856 102801 110389605
Cerebral haemorrhage 20.07 10.21 111 96782 64857 110427549
Weight decreased 19.90 10.21 544 96349 467513 110024893
Inappropriate antidiuretic hormone secretion 19.78 10.21 70 96823 33781 110458625
Diabetic ketoacidosis 19.66 10.21 81 96812 41977 110450429
Myositis 19.62 10.21 66 96827 31050 110461356
Transient ischaemic attack 19.55 10.21 109 96784 63873 110428533
Toxic optic neuropathy 19.54 10.21 13 96880 1315 110491091
Prescribed overdose 19.53 10.21 29 96864 87552 110404854
Haematuria 19.43 10.21 132 96761 82873 110409533
Hypercholesterolaemia 19.37 10.21 31 96862 90806 110401600
Polymyalgia rheumatica 19.36 10.21 26 96867 6416 110485990
Vascular pseudoaneurysm 19.30 10.21 21 96872 4169 110488237
Glycosuria 19.28 10.21 17 96876 2613 110489793
Low density lipoprotein increased 19.26 10.21 34 96859 10632 110481774
Renal failure 19.24 10.21 292 96601 226282 110266124
Dry mouth 19.15 10.21 100 96793 199848 110292558
Coeliac disease 19.03 10.21 7 96886 43180 110449226
Acute respiratory failure 19.02 10.21 122 96771 75138 110417268
Restless legs syndrome 18.99 10.21 56 96837 24570 110467836
Rectal abscess 18.92 10.21 17 96876 2679 110489727
Left ventricular failure 18.90 10.21 35 96858 11354 110481052
Back injury 18.77 10.21 9 96884 47390 110445016
Hip arthroplasty 18.68 10.21 13 96880 55800 110436606
Hepatitis cholestatic 18.68 10.21 45 96848 17521 110474885
Acute interstitial pneumonitis 18.54 10.21 13 96880 1433 110490973
Femoral artery aneurysm 18.19 10.21 7 96886 218 110492188
Toxic epidermal necrolysis 17.97 10.21 14 96879 56713 110435693
Syncope 17.97 10.21 263 96630 202273 110290133
Atrioventricular block first degree 17.96 10.21 39 96854 14186 110478220
Eosinophilia 17.90 10.21 99 96794 57837 110434569
Electrocardiogram ST segment depression 17.90 10.21 23 96870 5438 110486968
Renal-limited thrombotic microangiopathy 17.86 10.21 9 96884 539 110491867
Hypokalaemia 17.83 10.21 241 96652 182207 110310199
Ocular discomfort 17.79 10.21 29 96864 8504 110483902
Feeling abnormal 17.78 10.21 239 96654 180472 110311934
Lower limb fracture 17.74 10.21 24 96869 75324 110417082
Sedation 17.65 10.21 21 96872 69662 110422744
Carnitine palmitoyltransferase deficiency 17.36 10.21 4 96889 18 110492388
Asthenia 17.23 10.21 753 96140 688246 109804160
Haemorrhagic transformation stroke 17.19 10.21 17 96876 3020 110489386
Vitamin B12 decreased 17.01 10.21 22 96871 5235 110487171
Renal disorder 16.96 10.21 87 96806 49392 110443014
Corneal dystrophy 16.92 10.21 7 96886 264 110492142
Therapy cessation 16.89 10.21 81 96812 44776 110447630
International normalised ratio increased 16.87 10.21 132 96761 86640 110405766
Hospice care 16.67 10.21 35 96858 12438 110479968
Intentional self-injury 16.61 10.21 6 96887 37423 110454983
Post viral fatigue syndrome 16.56 10.21 7 96886 279 110492127
Fatigue 16.48 10.21 1257 95636 1214701 109277705
Mixed liver injury 16.27 10.21 34 96859 12045 110480361
Heart disease congenital 16.26 10.21 9 96884 653 110491753
Coronary artery disease 16.18 10.21 113 96780 71577 110420829
Somnolence 16.01 10.21 357 96536 297092 110195314
Vision blurred 15.88 10.21 178 96715 128844 110363562
Foreign body sensation in eyes 15.86 10.21 17 96876 3317 110489089
Sinus arrhythmia 15.85 10.21 14 96879 2156 110490250
Onychomycosis 15.75 10.21 7 96886 38524 110453882
Patent ductus arteriosus 15.71 10.21 6 96887 183 110492223
Osteoporosis 15.68 10.21 33 96860 87119 110405287
Epistaxis 15.66 10.21 179 96714 130193 110362213
Alexithymia 15.51 10.21 4 96889 31 110492375
Device expulsion 15.42 10.21 4 96889 30887 110461519
Myotonic dystrophy 15.41 10.21 6 96887 193 110492213
Haemorrhage intracranial 15.32 10.21 58 96835 28911 110463495
Eosinophilic pleural effusion 15.27 10.21 8 96885 520 110491886
Finger deformity 15.21 10.21 5 96888 33087 110459319
Behaviour disorder 15.21 10.21 29 96864 9618 110482788
Lower gastrointestinal haemorrhage 15.19 10.21 43 96850 18443 110473963
Chest wall haematoma 15.17 10.21 8 96885 527 110491879
Axonal neuropathy 15.06 10.21 14 96879 2304 110490102
Head injury 15 10.21 76 96817 42941 110449465
Cough 14.94 10.21 519 96374 461122 110031284
Myopathy toxic 14.90 10.21 11 96882 1314 110491092
Anti factor VIII antibody positive 14.89 10.21 5 96888 104 110492302
Inappropriate schedule of product administration 14.88 10.21 256 96637 203381 110289025
Drug tolerance decreased 14.88 10.21 3 96890 27537 110464869
Necrotising myositis 14.79 10.21 13 96880 1989 110490417
Cardiac murmur functional 14.70 10.21 4 96889 39 110492367
Peptic ulcer 14.69 10.21 25 96868 7594 110484812
Gastrointestinal haemorrhage 14.31 10.21 214 96679 165304 110327102
Bradycardia 14.21 10.21 203 96690 155314 110337092
Anaemia 14.13 10.21 600 96293 546486 109945920
Squamous cell carcinoma of skin 14.12 10.21 40 96853 17163 110475243
Erythematotelangiectatic rosacea 13.99 10.21 5 96888 126 110492280
Cholestatic liver injury 13.95 10.21 24 96869 7352 110485054
Acute myocardial infarction 13.91 10.21 123 96770 83654 110408752
Mouth ulceration 13.88 10.21 13 96880 48125 110444281
Speech disorder 13.87 10.21 97 96796 61472 110430934
Dizziness 13.86 10.21 746 96147 697447 109794959
Pancreatic steatosis 13.80 10.21 12 96881 1810 110490596
Arteriovenous fistula 13.78 10.21 11 96882 1474 110490932
Back pain 13.78 10.21 424 96469 370572 110121834
Stress 13.73 10.21 147 96746 105201 110387205
Synovial disorder 13.73 10.21 15 96878 2992 110489414
Hypersensitivity vasculitis 13.69 10.21 23 96870 6914 110485492
Electrocardiogram PR prolongation 13.68 10.21 12 96881 1831 110490575
Bladder cyst 13.59 10.21 5 96888 137 110492269
Acquired haemophilia 13.56 10.21 14 96879 2617 110489789
Anti-neutrophil cytoplasmic antibody positive vasculitis 13.52 10.21 20 96873 5397 110487009
Dehydration 13.36 10.21 330 96563 279181 110213225
Atrial hypertrophy 13.32 10.21 4 96889 57 110492349
Subacute cutaneous lupus erythematosus 13.28 10.21 19 96874 4975 110487431
Ligament rupture 13.23 10.21 17 96876 4018 110488388
AST/ALT ratio abnormal 13.23 10.21 5 96888 148 110492258
Drug resistance 13.23 10.21 18 96875 56356 110436050
Erectile dysfunction 13.19 10.21 41 96852 18515 110473891
Knee arthroplasty 13.08 10.21 23 96870 64925 110427481
Urinary incontinence 13.05 10.21 80 96813 48507 110443899
Eye irritation 13.03 10.21 61 96832 33391 110459015
Electrocardiogram abnormal 12.98 10.21 41 96852 18668 110473738
Akinesia 12.90 10.21 16 96877 3651 110488755
Ligament sprain 12.83 10.21 37 96856 16031 110476375
Blood triglycerides increased 12.73 10.21 48 96845 23878 110468528
Blood glucose abnormal 12.58 10.21 32 96861 12884 110479522
Vessel puncture site bruise 12.56 10.21 7 96886 515 110491891
Diplopia 12.55 10.21 71 96822 41823 110450583
Muscle haemorrhage 12.54 10.21 22 96871 6847 110485559
Renal arteriosclerosis 12.53 10.21 7 96886 517 110491889
Nasopharyngitis 12.50 10.21 257 96636 394104 110098302
Gastric infection 12.49 10.21 17 96876 4249 110488157
Diabetic wound 12.40 10.21 4 96889 73 110492333
Dry gangrene 12.34 10.21 9 96884 1055 110491351
Cardiac failure 12.34 10.21 232 96661 187394 110305012
Disseminated mucormycosis 12.33 10.21 12 96881 2090 110490316
Mucosal inflammation 12.33 10.21 43 96850 96098 110396308
Thrombotic stroke 12.29 10.21 8 96885 780 110491626
Muscle strain 12.24 10.21 29 96864 11173 110481233
Nail disorder 12.14 10.21 20 96873 57915 110434491
Hypoxic-ischaemic encephalopathy 12.03 10.21 25 96868 8822 110483584
Mammogram abnormal 12.00 10.21 7 96886 561 110491845
Bacteriuria 11.98 10.21 10 96883 1428 110490978
Prostate cancer metastatic 11.98 10.21 18 96875 4925 110487481
Hyperlactacidaemia 11.96 10.21 24 96869 8262 110484144
Thyroiditis 11.93 10.21 21 96872 6552 110485854
Appendicitis 11.91 10.21 5 96888 28459 110463947
Uterine dilation and evacuation 11.90 10.21 3 96890 21 110492385
Tendon disorder 11.86 10.21 24 96869 8313 110484093
Liver function test increased 11.77 10.21 39 96854 88509 110403897
Intentional overdose 11.73 10.21 68 96825 132433 110359973
Dystonia 11.68 10.21 4 96889 25801 110466605
Pyuria 11.66 10.21 13 96880 2650 110489756
Sinus node dysfunction 11.65 10.21 25 96868 9022 110483384
Sopor 11.60 10.21 9 96884 36537 110455869
Adenocarcinoma of appendix 11.57 10.21 4 96889 91 110492315
Haematoma muscle 11.52 10.21 16 96877 4074 110488332
Feeling hot 11.52 10.21 41 96852 91065 110401341
Exostosis 11.48 10.21 14 96879 45942 110446464
Scratch 11.46 10.21 31 96862 12948 110479458
Renal tubular necrosis 11.45 10.21 55 96838 30420 110461986
Hypoparathyroidism 11.44 10.21 10 96883 1520 110490886
Postictal paralysis 11.43 10.21 7 96886 614 110491792
Decreased appetite 11.42 10.21 518 96375 475328 110017078
Sleep disorder 11.41 10.21 115 96778 198529 110293877
Adenocarcinoma metastatic 11.39 10.21 6 96887 394 110492012
Large intestine polyp 11.30 10.21 34 96859 15083 110477323
Plasma cell myeloma 11.29 10.21 94 96799 62842 110429564
Heat stroke 11.27 10.21 11 96882 1924 110490482
Pericardial haemorrhage 11.24 10.21 18 96875 5199 110487207
Immunosuppressant drug level decreased 11.24 10.21 13 96880 2758 110489648
Hypoglycaemia 11.19 10.21 153 96740 115951 110376455
Anti factor X activity increased 11.18 10.21 4 96889 101 110492305
Iron deficiency anaemia 11.17 10.21 56 96837 31503 110460903
Intensive care unit acquired weakness 11.17 10.21 12 96881 2347 110490059
Cell death 11.16 10.21 19 96874 5772 110486634
Fixed eruption 11.10 10.21 16 96877 4216 110488190
Hypovolaemic shock 11.09 10.21 33 96860 14550 110477856
Urinary tract disorder 11.04 10.21 19 96874 5825 110486581
Symptom recurrence 11.03 10.21 17 96876 4755 110487651
Blood cholesterol increased 11.02 10.21 106 96787 184679 110307727
Heart transplant 10.90 10.21 10 96883 1618 110490788
Dermatitis bullous 10.89 10.21 37 96856 17492 110474914
Brain herniation 10.85 10.21 24 96869 8839 110483567
Peak expiratory flow rate abnormal 10.79 10.21 4 96889 112 110492294
Xerosis 10.79 10.21 10 96883 1639 110490767
Poor dental condition 10.78 10.21 7 96886 680 110491726
Pre-existing condition improved 10.76 10.21 20 96873 6506 110485900
Pleurisy 10.76 10.21 29 96864 12087 110480319
Eye pain 10.74 10.21 78 96815 50021 110442385
Transaminases abnormal 10.66 10.21 8 96885 980 110491426
Splenic vein thrombosis 10.61 10.21 8 96885 987 110491419
Oropharyngeal pain 10.59 10.21 172 96721 135104 110357302
Schizophrenia 10.57 10.21 3 96890 21823 110470583
Therapeutic drug monitoring analysis incorrectly performed 10.55 10.21 7 96886 705 110491701
Conjunctival haemorrhage 10.53 10.21 20 96873 6613 110485793
Human ehrlichiosis 10.52 10.21 7 96886 708 110491698
Eosinophilic pneumonia 10.51 10.21 21 96872 7206 110485200
Dyspnoea 10.48 10.21 1115 95778 1105757 109386649
Essential hypertension 10.47 10.21 22 96871 7825 110484581
Muscle discomfort 10.44 10.21 6 96887 468 110491938
Neurotoxicity 10.39 10.21 13 96880 42194 110450212
Cutaneous lupus erythematosus 10.36 10.21 14 96879 3474 110488932
Eye haemorrhage 10.28 10.21 28 96865 11746 110480660
Hepatitis fulminant 10.28 10.21 23 96870 8537 110483869
Instillation site pain 10.25 10.21 7 96886 739 110491667

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AA03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D057847 Lipid Regulating Agents
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:25212 metabolite
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

C10AA HMG CoA reductase inhibitors 7 drugs
atorvastatincerivastatinfluvastatinlovastatinpitavastatinrosuvastatinsimvastatin
C10BA Combinations of various lipid modifying agents 9 drugs
atorvastatinbempedoic acidezetimibefenofibratelovastatinnicotinic acidpitavastatinrosuvastatinsimvastatin
C10BX Lipid modifying agents in combination with other drugs 14 drugs
acetylsalicylic acidamlodipineatorvastatincandesartan cilexetilfimasartanindapamidelisinoprilnebivololperindoprilramiprilrosuvastatinsimvastatin show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Primary Prevention of Coronary Heart Disease indication
Prevention of Transient Ischemic Attacks indication
Myocardial Infarction Prevention indication
Slow Progression of Coronary Artery Disease indication
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Gastrointestinal ulcer contraindication 40845000
Low blood pressure contraindication 45007003
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
von Willebrand disorder contraindication 128105004 DOID:12531
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Osteolysis contraindication 203522001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Acute erosive gastritis contraindication 444926003
Uncontrolled Epilepsy contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic
pKa2 13.74 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 7.52 CHEMBL CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.38 CHEMBL
Solute carrier family 22 member 6 Transporter Ki 4.28 CHEMBL

External reference:

IDSource
4020548 VUID
N0000148255 NUI
D00893 KEGG_DRUG
81131-70-6 SECONDARY_CAS_RN
4020369 VANDF
4020548 VANDF
C0085542 UMLSCUI
CHEBI:63618 CHEBI
CHEMBL1144 ChEMBL_ID
CHEMBL690 ChEMBL_ID
D017035 MESH_DESCRIPTOR_UI
DB00175 DRUGBANK_ID
54687 PUBCHEM_CID
2953 IUPHAR_LIGAND_ID
6070 INN_ID
KXO2KT9N0G UNII
203144 RXNORM
1884 MMSL
5343 MMSL
81574 MMSL
d00348 MMSL
003606 NDDF
003607 NDDF
373566006 SNOMEDCT_US
96305006 SNOMEDCT_US
96306007 SNOMEDCT_US
KXO2KT9N0G INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-0771 TABLET 10 mg ORAL ANDA 24 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7201 TABLET 20 mg ORAL ANDA 24 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7202 TABLET 40 mg ORAL ANDA 24 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0480-7270 TABLET 80 mg ORAL ANDA 25 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0615-8539 TABLET 10 mg ORAL ANDA 30 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0615-8540 TABLET 20 mg ORAL ANDA 30 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0615-8541 TABLET 40 mg ORAL ANDA 30 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0615-8542 TABLET 80 mg ORAL ANDA 30 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0615-8618 TABLET 10 mg ORAL ANDA 24 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0615-8619 TABLET 20 mg ORAL ANDA 24 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0615-8620 TABLET 40 mg ORAL ANDA 24 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0615-8621 TABLET 80 mg ORAL ANDA 24 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0904-5891 TABLET 10 mg ORAL ANDA 24 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0904-5892 TABLET 20 mg ORAL ANDA 24 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0904-5893 TABLET 40 mg ORAL ANDA 24 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-440 TABLET 10 mg ORAL ANDA 27 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-505 TABLET 20 mg ORAL ANDA 27 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-507 TABLET 40 mg ORAL ANDA 27 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16714-558 TABLET 10 mg ORAL ANDA 25 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16714-559 TABLET 20 mg ORAL ANDA 25 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16714-560 TABLET 40 mg ORAL ANDA 25 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16714-570 TABLET 80 mg ORAL ANDA 25 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 16729-008 TABLET 10 mg ORAL ANDA 24 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 16729-009 TABLET 20 mg ORAL ANDA 24 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 16729-010 TABLET 40 mg ORAL ANDA 24 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 16729-011 TABLET 80 mg ORAL ANDA 24 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-178 TABLET 10 mg ORAL ANDA 24 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-179 TABLET 20 mg ORAL ANDA 24 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-180 TABLET 40 mg ORAL ANDA 24 sections
pravastatin sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-867 TABLET 20 mg ORAL ANDA 26 sections