Stem definition | Drug id | CAS RN |
---|---|---|
prostaglandins | 343 | 88430-50-6 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 19 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.01 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 1, 1992 | YEAR INTRODUCED |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cardiac failure | 113.10 | 29.23 | 63 | 2701 | 75977 | 50526383 |
Pulmonary hypertension | 107.87 | 29.23 | 47 | 2717 | 33370 | 50568990 |
Concomitant disease aggravated | 101.38 | 29.23 | 31 | 2733 | 8060 | 50594300 |
Right ventricular failure | 95.47 | 29.23 | 35 | 2729 | 15858 | 50586502 |
Transfusion | 79.65 | 29.23 | 29 | 2735 | 12876 | 50589484 |
Brain natriuretic peptide increased | 68.18 | 29.23 | 20 | 2744 | 4507 | 50597853 |
Hepatic function abnormal | 65.23 | 29.23 | 33 | 2731 | 32648 | 50569712 |
Upper respiratory tract inflammation | 61.12 | 29.23 | 16 | 2748 | 2373 | 50599987 |
Anaemia | 56.45 | 29.23 | 69 | 2695 | 252387 | 50349973 |
Pulmonary arterial hypertension | 50.98 | 29.23 | 24 | 2740 | 20295 | 50582065 |
Gamma-glutamyltransferase increased | 50.73 | 29.23 | 27 | 2737 | 29596 | 50572764 |
Platelet count decreased | 49.12 | 29.23 | 42 | 2722 | 100684 | 50501676 |
Iron deficiency anaemia | 42.58 | 29.23 | 20 | 2744 | 16814 | 50585546 |
Blood pressure decreased | 41.73 | 29.23 | 30 | 2734 | 55879 | 50546481 |
Aspartate aminotransferase increased | 34.92 | 29.23 | 31 | 2733 | 77967 | 50524393 |
Pulmonary arterial pressure increased | 34.27 | 29.23 | 11 | 2753 | 3337 | 50599023 |
Red blood cell count decreased | 31.95 | 29.23 | 21 | 2743 | 33814 | 50568546 |
Haematocrit decreased | 31.32 | 29.23 | 21 | 2743 | 34955 | 50567405 |
Renal impairment | 29.81 | 29.23 | 28 | 2736 | 75633 | 50526727 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Right ventricular failure | 88.84 | 30.05 | 26 | 1178 | 7864 | 29565459 |
Concomitant disease aggravated | 76.84 | 30.05 | 21 | 1183 | 4957 | 29568366 |
Cardiac failure | 56.95 | 30.05 | 37 | 1167 | 79250 | 29494073 |
Brain natriuretic peptide increased | 47.83 | 30.05 | 14 | 1190 | 4216 | 29569107 |
Pulmonary hypertension | 36.75 | 30.05 | 17 | 1187 | 18591 | 29554732 |
Pulmonary arterial hypertension | 32.50 | 30.05 | 12 | 1192 | 7437 | 29565886 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Right ventricular failure | 170.40 | 27.09 | 61 | 4191 | 21410 | 64473070 |
Concomitant disease aggravated | 168.75 | 27.09 | 52 | 4200 | 11490 | 64482990 |
Cardiac failure | 146.26 | 27.09 | 97 | 4155 | 132276 | 64362204 |
Pulmonary hypertension | 135.44 | 27.09 | 63 | 4189 | 43076 | 64451404 |
Brain natriuretic peptide increased | 109.88 | 27.09 | 34 | 4218 | 7599 | 64486881 |
Transfusion | 81.40 | 27.09 | 34 | 4218 | 17960 | 64476520 |
Hepatic function abnormal | 75.40 | 27.09 | 49 | 4203 | 64264 | 64430216 |
Pulmonary arterial hypertension | 73.24 | 27.09 | 35 | 4217 | 25332 | 64469148 |
Upper respiratory tract inflammation | 72.40 | 27.09 | 21 | 4231 | 3761 | 64490719 |
Anaemia | 64.41 | 27.09 | 100 | 4152 | 378580 | 64115900 |
Platelet count decreased | 56.26 | 27.09 | 62 | 4190 | 167649 | 64326831 |
Iron deficiency anaemia | 50.69 | 27.09 | 26 | 4226 | 21863 | 64472617 |
Gamma-glutamyltransferase increased | 42.71 | 27.09 | 31 | 4221 | 48479 | 64446001 |
Blood pressure decreased | 38.12 | 27.09 | 37 | 4215 | 86162 | 64408318 |
Aspartate aminotransferase increased | 37.92 | 27.09 | 43 | 4209 | 119745 | 64374735 |
Pulmonary arterial pressure increased | 33.76 | 27.09 | 12 | 4240 | 4104 | 64490376 |
Alanine aminotransferase increased | 31.23 | 27.09 | 42 | 4210 | 138989 | 64355491 |
Red blood cell count decreased | 29.72 | 27.09 | 25 | 4227 | 48361 | 64446119 |
Haemoglobin decreased | 29.56 | 27.09 | 49 | 4203 | 195014 | 64299466 |
Fatigue | 28.90 | 27.09 | 7 | 4245 | 748723 | 63745757 |
None
Source | Code | Description |
---|---|---|
ATC | B01AC19 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Platelet aggregation inhibitors excl. heparin |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D010975 | Platelet Aggregation Inhibitors |
MeSH PA | D014665 | Vasodilator Agents |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:50427 | platelet aggregation inhibitors |
CHEBI has role | CHEBI:66900 | prostaglandin receptor agonists |
CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pulmonary arterial hypertension | indication | 11399002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.76 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostacyclin receptor | GPCR | AGONIST | IC50 | 8.37 | WOMBAT-PK | DRUG LABEL | |||
Prostaglandin E2 receptor EP3 subtype | GPCR | AGONIST | Ki | 6.17 | IUPHAR | ||||
Prostaglandin E2 receptor EP4 subtype | GPCR | AGONIST | Ki | 5.14 | IUPHAR | ||||
Prostacyclin receptor | GPCR | AGONIST | Ki | 7.80 | IUPHAR | ||||
Prostacyclin receptor | GPCR | AGONIST | Ki | 7.72 | IUPHAR |
ID | Source |
---|---|
D01551 | KEGG_DRUG |
88475-69-8 | SECONDARY_CAS_RN |
C0053336 | UMLSCUI |
CHEBI:135633 | CHEBI |
CHEMBL1207745 | ChEMBL_ID |
CHEMBL435883 | ChEMBL_ID |
DB05229 | DRUGBANK_ID |
C048081 | MESH_SUPPLEMENTAL_RECORD_UI |
6917951 | PUBCHEM_CID |
1967 | IUPHAR_LIGAND_ID |
6261 | INN_ID |
35E3NJJ4O6 | UNII |
010867 | NDDF |
010868 | NDDF |
None