Stem definition | Drug id | CAS RN |
---|---|---|
blood coagulation factor XA inhibitors, antithrombotics | 4897 | 480449-70-5 |
Dose | Unit | Route |
---|---|---|
60 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Hosey CM, Chan R, Benet LZ |
Vd (Volume of distribution) | 1.53 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.19 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.50 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 6.70 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 19, 2015 | EMA | Daiichi Sankyo Europe GmbH | |
Jan. 8, 2015 | FDA | DAIICHI SANKYO | |
April 22, 2011 | PMDA | DAIICHI SANKYO COMPANY, Limited |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 265.94 | 23.02 | 204 | 7983 | 142230 | 50454707 |
Anaemia | 141.20 | 23.02 | 188 | 7999 | 252268 | 50344669 |
Haematochezia | 118.19 | 23.02 | 76 | 8111 | 39806 | 50557131 |
Melaena | 104.68 | 23.02 | 61 | 8126 | 26803 | 50570134 |
Cardiac failure | 95.83 | 23.02 | 87 | 8100 | 75953 | 50520984 |
Labelled drug-drug interaction medication error | 88.23 | 23.02 | 40 | 8147 | 10437 | 50586500 |
Lymphatic fistula | 87.38 | 23.02 | 21 | 8166 | 729 | 50596208 |
Femoral hernia incarcerated | 87.07 | 23.02 | 21 | 8166 | 740 | 50596197 |
Arterial haemorrhage | 85.65 | 23.02 | 24 | 8163 | 1533 | 50595404 |
Pancreatic steatosis | 82.91 | 23.02 | 21 | 8166 | 908 | 50596029 |
Pallor | 80.77 | 23.02 | 49 | 8138 | 23150 | 50573787 |
Product monitoring error | 80.12 | 23.02 | 26 | 8161 | 2738 | 50594199 |
Wound infection pseudomonas | 76.35 | 23.02 | 21 | 8166 | 1252 | 50595685 |
Atrial fibrillation | 74.62 | 23.02 | 87 | 8100 | 101658 | 50495279 |
Arrhythmia | 73.94 | 23.02 | 53 | 8134 | 33079 | 50563858 |
Renal impairment | 73.44 | 23.02 | 75 | 8112 | 75586 | 50521351 |
Drug ineffective | 71.80 | 23.02 | 22 | 8165 | 819311 | 49777626 |
Haematuria | 71.40 | 23.02 | 47 | 8140 | 25566 | 50571371 |
Aortic valve stenosis | 70.34 | 23.02 | 24 | 8163 | 2951 | 50593986 |
Seroma | 68.69 | 23.02 | 21 | 8166 | 1820 | 50595117 |
Haemarthrosis | 66.96 | 23.02 | 23 | 8164 | 2885 | 50594052 |
Tachyarrhythmia | 66.41 | 23.02 | 25 | 8162 | 4080 | 50592857 |
Hyponatraemia | 60.35 | 23.02 | 76 | 8111 | 96063 | 50500874 |
Eructation | 56.22 | 23.02 | 26 | 8161 | 7095 | 50589842 |
Faecaloma | 53.16 | 23.02 | 25 | 8162 | 7083 | 50589854 |
Wound dehiscence | 51.14 | 23.02 | 21 | 8166 | 4309 | 50592628 |
Diverticulum intestinal | 51.05 | 23.02 | 23 | 8164 | 5910 | 50591027 |
Hyperkalaemia | 50.91 | 23.02 | 50 | 8137 | 48039 | 50548898 |
Hepatic cyst | 50.39 | 23.02 | 21 | 8166 | 4472 | 50592465 |
Aortic arteriosclerosis | 49.95 | 23.02 | 22 | 8165 | 5360 | 50591577 |
Gastrointestinal haemorrhage | 49.26 | 23.02 | 60 | 8127 | 73261 | 50523676 |
Inflammatory marker increased | 48.98 | 23.02 | 22 | 8165 | 5612 | 50591325 |
Cerebral infarction | 46.90 | 23.02 | 34 | 8153 | 21570 | 50575367 |
Anuria | 45.01 | 23.02 | 26 | 8161 | 11218 | 50585719 |
Internal haemorrhage | 44.06 | 23.02 | 19 | 8168 | 4398 | 50592539 |
Oedema peripheral | 42.93 | 23.02 | 85 | 8102 | 157876 | 50439061 |
Dyspnoea | 42.66 | 23.02 | 188 | 7999 | 547420 | 50049517 |
Aplastic anaemia | 42.43 | 23.02 | 22 | 8165 | 7681 | 50589256 |
Groin pain | 42.22 | 23.02 | 23 | 8164 | 8868 | 50588069 |
Bradycardia | 40.50 | 23.02 | 51 | 8136 | 64375 | 50532562 |
Postoperative wound infection | 40.46 | 23.02 | 22 | 8165 | 8453 | 50588484 |
Escherichia infection | 40.37 | 23.02 | 24 | 8163 | 10917 | 50586020 |
Chorea | 36.39 | 23.02 | 12 | 8175 | 1328 | 50595609 |
Cardiovascular disorder | 36.16 | 23.02 | 22 | 8165 | 10432 | 50586505 |
Myelodysplastic syndrome | 35.57 | 23.02 | 25 | 8162 | 15107 | 50581830 |
Embolic stroke | 34.80 | 23.02 | 15 | 8172 | 3469 | 50593468 |
Tricuspid valve incompetence | 34.52 | 23.02 | 23 | 8164 | 12747 | 50584190 |
Decreased appetite | 34.36 | 23.02 | 90 | 8097 | 200833 | 50396104 |
Syncope | 33.65 | 23.02 | 60 | 8127 | 102942 | 50493995 |
Angina pectoris | 33.00 | 23.02 | 30 | 8157 | 26158 | 50570779 |
Joint dislocation | 32.83 | 23.02 | 22 | 8165 | 12311 | 50584626 |
Cardiogenic shock | 32.61 | 23.02 | 24 | 8163 | 15575 | 50581362 |
Tachycardia | 32.44 | 23.02 | 58 | 8129 | 99705 | 50497232 |
Left ventricular dysfunction | 31.03 | 23.02 | 20 | 8167 | 10486 | 50586451 |
Pulmonary hypertension | 30.35 | 23.02 | 32 | 8155 | 33385 | 50563552 |
BRASH syndrome | 30.24 | 23.02 | 7 | 8180 | 206 | 50596731 |
Mitral valve incompetence | 30.19 | 23.02 | 24 | 8163 | 17447 | 50579490 |
Rhonchi | 30.03 | 23.02 | 12 | 8175 | 2295 | 50594642 |
Thrombophlebitis migrans | 28.94 | 23.02 | 6 | 8181 | 104 | 50596833 |
Pain | 28.62 | 23.02 | 31 | 8156 | 578872 | 50018065 |
Product prescribing error | 28.36 | 23.02 | 25 | 8162 | 20936 | 50576001 |
Gastroenteritis clostridial | 27.91 | 23.02 | 8 | 8179 | 554 | 50596383 |
Sopor | 27.48 | 23.02 | 24 | 8163 | 19855 | 50577082 |
Urinary retention | 27.27 | 23.02 | 27 | 8160 | 26163 | 50570774 |
Cerebral haemorrhage | 26.54 | 23.02 | 27 | 8160 | 27025 | 50569912 |
Osteopenia | 26.50 | 23.02 | 22 | 8165 | 16996 | 50579941 |
Electrolyte imbalance | 26.33 | 23.02 | 22 | 8165 | 17147 | 50579790 |
Streptococcal sepsis | 26.18 | 23.02 | 10 | 8177 | 1697 | 50595240 |
Hepatic function abnormal | 25.68 | 23.02 | 29 | 8158 | 32652 | 50564285 |
Hiatus hernia | 25.06 | 23.02 | 22 | 8165 | 18322 | 50578615 |
Oesophageal mucosal tear | 24.29 | 23.02 | 4 | 8183 | 17 | 50596920 |
Dysuria | 23.61 | 23.02 | 26 | 8161 | 28478 | 50568459 |
Ischaemic stroke | 23.56 | 23.02 | 20 | 8167 | 15928 | 50581009 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 107.01 | 19.93 | 124 | 6599 | 102733 | 29465071 |
Pelvic mass | 94.64 | 19.93 | 19 | 6704 | 193 | 29567611 |
Haematuria | 90.28 | 19.93 | 77 | 6646 | 44062 | 29523742 |
Cardiac failure | 83.05 | 19.93 | 96 | 6627 | 79191 | 29488613 |
Cerebral infarction | 71.81 | 19.93 | 53 | 6670 | 24622 | 29543182 |
Prostate cancer recurrent | 71.56 | 19.93 | 20 | 6703 | 895 | 29566909 |
Blood urea abnormal | 70.68 | 19.93 | 19 | 6704 | 734 | 29567070 |
Malignant transformation | 68.76 | 19.93 | 19 | 6704 | 815 | 29566989 |
Blood electrolytes abnormal | 67.39 | 19.93 | 19 | 6704 | 878 | 29566926 |
Melaena | 64.96 | 19.93 | 55 | 6668 | 31121 | 29536683 |
Anaemia | 64.28 | 19.93 | 141 | 6582 | 200810 | 29366994 |
Renal impairment | 63.49 | 19.93 | 85 | 6638 | 81248 | 29486556 |
Respiratory tract haemorrhage | 57.21 | 19.93 | 17 | 6706 | 947 | 29566857 |
Atrial fibrillation | 49.30 | 19.93 | 87 | 6636 | 105559 | 29462245 |
Oedema peripheral | 46.67 | 19.93 | 84 | 6639 | 103473 | 29464331 |
Haematochezia | 45.90 | 19.93 | 49 | 6674 | 36934 | 29530870 |
Dyspnoea | 44.89 | 19.93 | 169 | 6554 | 326563 | 29241241 |
Embolic stroke | 41.57 | 19.93 | 19 | 6704 | 3587 | 29564217 |
Drug ineffective | 35.95 | 19.93 | 19 | 6704 | 363151 | 29204653 |
Hydronephrosis | 35.37 | 19.93 | 23 | 6700 | 8707 | 29559097 |
Labelled drug-drug interaction medication error | 35.08 | 19.93 | 26 | 6697 | 12133 | 29555671 |
Interstitial lung disease | 34.23 | 19.93 | 53 | 6670 | 57665 | 29510139 |
Epistaxis | 29.99 | 19.93 | 47 | 6676 | 51657 | 29516147 |
Pallor | 29.93 | 19.93 | 30 | 6693 | 20994 | 29546810 |
Procedural failure | 29.36 | 19.93 | 6 | 6717 | 67 | 29567737 |
Pseudarthrosis | 28.81 | 19.93 | 6 | 6717 | 74 | 29567730 |
Cerebral haemorrhage | 26.24 | 19.93 | 34 | 6689 | 31392 | 29536412 |
Haemorrhage | 26.17 | 19.93 | 41 | 6682 | 45031 | 29522773 |
Tracheal pain | 25.45 | 19.93 | 5 | 6718 | 45 | 29567759 |
Pulmonary alveolar haemorrhage | 23.88 | 19.93 | 16 | 6707 | 6364 | 29561440 |
Skin irritation | 23.78 | 19.93 | 14 | 6709 | 4447 | 29563357 |
Duodenal ulcer haemorrhage | 23.73 | 19.93 | 14 | 6709 | 4465 | 29563339 |
Haematoma | 22.39 | 19.93 | 27 | 6696 | 23185 | 29544619 |
Subdural haematoma | 22.37 | 19.93 | 24 | 6699 | 18169 | 29549635 |
Stress urinary incontinence | 21.94 | 19.93 | 5 | 6718 | 96 | 29567708 |
Haemothorax | 21.57 | 19.93 | 12 | 6711 | 3424 | 29564380 |
Haemoptysis | 20.88 | 19.93 | 30 | 6693 | 30520 | 29537284 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 346.11 | 17.31 | 319 | 14260 | 204106 | 64280047 |
Anaemia | 185.49 | 17.31 | 317 | 14262 | 378363 | 64105790 |
Cardiac failure | 161.20 | 17.31 | 173 | 14406 | 132200 | 64351953 |
Haematochezia | 151.19 | 17.31 | 123 | 14456 | 66250 | 64417903 |
Melaena | 147.42 | 17.31 | 111 | 14468 | 53437 | 64430716 |
Haematuria | 143.95 | 17.31 | 115 | 14464 | 60356 | 64423797 |
Renal impairment | 139.54 | 17.31 | 162 | 14417 | 134855 | 64349298 |
Cerebral infarction | 124.00 | 17.31 | 90 | 14489 | 40954 | 64443199 |
Atrial fibrillation | 110.70 | 17.31 | 163 | 14416 | 170926 | 64313227 |
Labelled drug-drug interaction medication error | 109.58 | 17.31 | 66 | 14513 | 21996 | 64462157 |
Pallor | 97.07 | 17.31 | 76 | 14503 | 38705 | 64445448 |
Drug ineffective | 89.98 | 17.31 | 39 | 14540 | 840208 | 63643945 |
Oedema peripheral | 87.09 | 17.31 | 164 | 14415 | 210153 | 64274000 |
Product monitoring error | 86.75 | 17.31 | 36 | 14543 | 5418 | 64478735 |
Lymphatic fistula | 80.17 | 17.31 | 21 | 14558 | 737 | 64483416 |
Femoral hernia incarcerated | 80.09 | 17.31 | 21 | 14558 | 740 | 64483413 |
Dyspnoea | 80.00 | 17.31 | 347 | 14232 | 718327 | 63765826 |
Arterial haemorrhage | 77.04 | 17.31 | 26 | 14553 | 2205 | 64481948 |
Prostate cancer recurrent | 75.73 | 17.31 | 20 | 14559 | 725 | 64483428 |
Pancreatic steatosis | 74.24 | 17.31 | 21 | 14558 | 987 | 64483166 |
Embolic stroke | 73.28 | 17.31 | 34 | 14545 | 6677 | 64477476 |
Wound infection pseudomonas | 65.55 | 17.31 | 21 | 14558 | 1512 | 64482641 |
Pelvic mass | 63.65 | 17.31 | 19 | 14560 | 1081 | 64483072 |
Malignant transformation | 62.96 | 17.31 | 19 | 14560 | 1122 | 64483031 |
Arrhythmia | 62.21 | 17.31 | 68 | 14511 | 52876 | 64431277 |
Blood urea abnormal | 61.89 | 17.31 | 19 | 14560 | 1189 | 64482964 |
Seroma | 59.53 | 17.31 | 21 | 14558 | 2033 | 64482120 |
Aortic valve stenosis | 58.87 | 17.31 | 26 | 14553 | 4554 | 64479599 |
Tachyarrhythmia | 58.04 | 17.31 | 28 | 14551 | 5998 | 64478155 |
Blood electrolytes abnormal | 54.54 | 17.31 | 19 | 14560 | 1772 | 64482381 |
Gastrointestinal haemorrhage | 53.23 | 17.31 | 102 | 14477 | 132210 | 64351943 |
Cerebral haemorrhage | 52.16 | 17.31 | 61 | 14518 | 51029 | 64433124 |
Respiratory tract haemorrhage | 50.08 | 17.31 | 17 | 14562 | 1467 | 64482686 |
Haemarthrosis | 49.46 | 17.31 | 24 | 14555 | 5205 | 64478948 |
Internal haemorrhage | 48.90 | 17.31 | 27 | 14552 | 7640 | 64476513 |
Interstitial lung disease | 47.76 | 17.31 | 82 | 14497 | 97650 | 64386503 |
Angina pectoris | 46.31 | 17.31 | 54 | 14525 | 45027 | 64439126 |
Diverticulum intestinal | 44.24 | 17.31 | 25 | 14554 | 7395 | 64476758 |
Hepatic cyst | 43.48 | 17.31 | 22 | 14557 | 5218 | 64478935 |
Dysuria | 42.57 | 17.31 | 50 | 14529 | 42007 | 64442146 |
Subdural haematoma | 41.91 | 17.31 | 41 | 14538 | 28013 | 64456140 |
Eructation | 41.80 | 17.31 | 26 | 14553 | 9165 | 64474988 |
Aortic arteriosclerosis | 41.39 | 17.31 | 24 | 14555 | 7452 | 64476701 |
Tachycardia | 40.24 | 17.31 | 98 | 14481 | 149481 | 64334672 |
Thrombophlebitis migrans | 39.84 | 17.31 | 10 | 14569 | 295 | 64483858 |
Wound dehiscence | 38.32 | 17.31 | 21 | 14558 | 5853 | 64478300 |
Bradycardia | 36.77 | 17.31 | 82 | 14497 | 118137 | 64366016 |
Groin pain | 36.71 | 17.31 | 26 | 14553 | 11367 | 64472786 |
Faecaloma | 35.58 | 17.31 | 24 | 14555 | 9704 | 64474449 |
Gastric haemorrhage | 34.97 | 17.31 | 27 | 14552 | 13454 | 64470699 |
Decreased appetite | 34.29 | 17.31 | 140 | 14439 | 281149 | 64203004 |
Postoperative wound infection | 34.26 | 17.31 | 24 | 14555 | 10312 | 64473841 |
Inflammatory marker increased | 33.69 | 17.31 | 22 | 14557 | 8429 | 64475724 |
Syncope | 31.97 | 17.31 | 93 | 14486 | 157542 | 64326611 |
Ischaemic stroke | 31.87 | 17.31 | 36 | 14543 | 28999 | 64455154 |
Drug intolerance | 31.59 | 17.31 | 3 | 14576 | 187989 | 64296164 |
Chorea | 31.12 | 17.31 | 13 | 14566 | 1987 | 64482166 |
Cardiovascular disorder | 31.09 | 17.31 | 27 | 14552 | 15854 | 64468299 |
Pulmonary alveolar haemorrhage | 30.86 | 17.31 | 22 | 14557 | 9716 | 64474437 |
Hydronephrosis | 29.66 | 17.31 | 25 | 14554 | 14100 | 64470053 |
Pain | 29.45 | 17.31 | 50 | 14529 | 553461 | 63930692 |
Drug hypersensitivity | 28.74 | 17.31 | 9 | 14570 | 237806 | 64246347 |
Hyponatraemia | 28.63 | 17.31 | 86 | 14493 | 148253 | 64335900 |
Electrocardiogram abnormal | 28.59 | 17.31 | 24 | 14555 | 13457 | 64470696 |
Procedural failure | 28.41 | 17.31 | 6 | 14573 | 80 | 64484073 |
Product dose omission issue | 28.20 | 17.31 | 5 | 14574 | 194742 | 64289411 |
Aplastic anaemia | 27.92 | 17.31 | 24 | 14555 | 13896 | 64470257 |
Product prescribing error | 27.80 | 17.31 | 37 | 14542 | 35232 | 64448921 |
Colon cancer | 27.69 | 17.31 | 23 | 14556 | 12716 | 64471437 |
Joint dislocation | 27.66 | 17.31 | 22 | 14557 | 11443 | 64472710 |
Thirst | 27.60 | 17.31 | 24 | 14555 | 14113 | 64470040 |
Tricuspid valve incompetence | 27.57 | 17.31 | 26 | 14553 | 16977 | 64467176 |
Toxicity to various agents | 27.53 | 17.31 | 25 | 14554 | 363488 | 64120665 |
Anuria | 26.99 | 17.31 | 27 | 14552 | 18937 | 64465216 |
Haemorrhage subcutaneous | 26.83 | 17.31 | 15 | 14564 | 4346 | 64479807 |
Upper gastrointestinal haemorrhage | 26.31 | 17.31 | 36 | 14543 | 35184 | 64448969 |
Escherichia infection | 26.15 | 17.31 | 24 | 14555 | 15144 | 64469009 |
Epistaxis | 26.06 | 17.31 | 64 | 14515 | 98067 | 64386086 |
Product used for unknown indication | 26.03 | 17.31 | 9 | 14570 | 821 | 64483332 |
Hyperkalaemia | 25.85 | 17.31 | 65 | 14514 | 101064 | 64383089 |
Haematoma | 25.52 | 17.31 | 41 | 14538 | 46209 | 64437944 |
Tracheal pain | 25.47 | 17.31 | 5 | 14574 | 45 | 64484108 |
Nasopharyngitis | 24.45 | 17.31 | 7 | 14572 | 196066 | 64288087 |
Rheumatoid arthritis | 24.26 | 17.31 | 4 | 14575 | 164290 | 64319863 |
Duodenal ulcer haemorrhage | 24.08 | 17.31 | 16 | 14563 | 6309 | 64477844 |
BRASH syndrome | 23.95 | 17.31 | 7 | 14572 | 370 | 64483783 |
Hepatic function abnormal | 23.91 | 17.31 | 48 | 14531 | 64265 | 64419888 |
Left ventricular dysfunction | 23.88 | 17.31 | 24 | 14555 | 16930 | 64467223 |
Haemorrhage | 23.50 | 17.31 | 54 | 14525 | 79297 | 64404856 |
Oesophageal mucosal tear | 23.35 | 17.31 | 4 | 14575 | 15 | 64484138 |
Sinusitis | 22.82 | 17.31 | 3 | 14576 | 145925 | 64338228 |
Haemothorax | 22.78 | 17.31 | 14 | 14565 | 4828 | 64479325 |
Putamen haemorrhage | 22.71 | 17.31 | 7 | 14572 | 444 | 64483709 |
Haemoptysis | 22.44 | 17.31 | 40 | 14539 | 49008 | 64435145 |
Urinary retention | 22.35 | 17.31 | 40 | 14539 | 49161 | 64434992 |
Electrolyte imbalance | 22.26 | 17.31 | 28 | 14551 | 25215 | 64458938 |
Anxiety | 22.21 | 17.31 | 9 | 14570 | 202640 | 64281513 |
Mitral valve incompetence | 22.00 | 17.31 | 28 | 14551 | 25510 | 64458643 |
Osteopenia | 21.89 | 17.31 | 22 | 14557 | 15518 | 64468635 |
Rhonchi | 21.55 | 17.31 | 12 | 14567 | 3451 | 64480702 |
Joint swelling | 21.37 | 17.31 | 11 | 14568 | 215371 | 64268782 |
Cardiac failure chronic | 21.07 | 17.31 | 17 | 14562 | 9024 | 64475129 |
Pneumonia bacterial | 20.65 | 17.31 | 21 | 14558 | 15014 | 64469139 |
Alopecia | 20.50 | 17.31 | 6 | 14573 | 165684 | 64318469 |
Depression | 20.31 | 17.31 | 8 | 14571 | 183283 | 64300870 |
Feeling abnormal | 20.30 | 17.31 | 3 | 14576 | 133599 | 64350554 |
Sopor | 20.19 | 17.31 | 29 | 14550 | 29632 | 64454521 |
Thalamus haemorrhage | 20.19 | 17.31 | 9 | 14570 | 1610 | 64482543 |
Pulmonary hypertension | 19.50 | 17.31 | 35 | 14544 | 43104 | 64441049 |
Sacroiliac joint dysfunction | 19.49 | 17.31 | 4 | 14575 | 46 | 64484107 |
Gastroenteritis clostridial | 18.93 | 17.31 | 7 | 14572 | 775 | 64483378 |
Skin irritation | 18.74 | 17.31 | 16 | 14563 | 9178 | 64474975 |
Endocarditis noninfective | 18.53 | 17.31 | 5 | 14574 | 197 | 64483956 |
Infusion related reaction | 18.52 | 17.31 | 7 | 14572 | 164460 | 64319693 |
Arthralgia | 18.36 | 17.31 | 46 | 14533 | 442214 | 64041939 |
Drug abuse | 17.90 | 17.31 | 4 | 14575 | 132370 | 64351783 |
Small intestinal haemorrhage | 17.82 | 17.31 | 11 | 14568 | 3822 | 64480331 |
Swelling | 17.74 | 17.31 | 7 | 14572 | 160211 | 64323942 |
Ventricular arrhythmia | 17.40 | 17.31 | 14 | 14565 | 7401 | 64476752 |
Hiatus hernia | 17.38 | 17.31 | 22 | 14557 | 19935 | 64464218 |
Myelodysplastic syndrome | 17.38 | 17.31 | 26 | 14553 | 27553 | 64456600 |
None
Source | Code | Description |
---|---|---|
ATC | B01AF03 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Direct factor Xa inhibitors |
MeSH PA | D000925 | Anticoagulants |
MeSH PA | D000991 | Antithrombins |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D065427 | Factor Xa Inhibitors |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D011480 | Protease Inhibitors |
MeSH PA | D015842 | Serine Proteinase Inhibitors |
FDA MoA | N0000175635 | Factor Xa Inhibitors |
FDA EPC | N0000175637 | Factor Xa Inhibitor |
CHEBI has role | CHEBI:50249 | anticoagulants |
CHEBI has role | CHEBI:50427 | platelet aggregation inhibitors |
CHEBI has role | CHEBI:68581 | factor Xa inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pulmonary embolism | indication | 59282003 | DOID:9477 |
Embolism | indication | 414086009 | |
Ischemic stroke | indication | 422504002 | |
Prevention of deep vein thrombosis | indication | 439993001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.7 | acidic |
pKa2 | 12.4 | acidic |
pKa3 | 6.8 | Basic |
pKa4 | 3.01 | Basic |
pKa5 | 2.14 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 15MG BASE | SAVAYSA | DAIICHI SANKYO INC | N206316 | Jan. 8, 2015 | RX | TABLET | ORAL | Aug. 9, 2022 | INFORMATION ADDED TO LABELING FROM PROSPECTIVE, RANDOMIZED, OPEN-LABEL, BLIND EVALUATOR (PROBE) STUDY EVALUATING THE EFFICACY AND SAFETY OF LOW MOLECULAR WEIGHT HEPARIN/EDOXABAN VERSUS DALTEPARIN IN VENOUS THROMBOEMBOLISM ASSOCIATED WITH CANCER |
EQ 30MG BASE | SAVAYSA | DAIICHI SANKYO INC | N206316 | Jan. 8, 2015 | RX | TABLET | ORAL | Aug. 9, 2022 | INFORMATION ADDED TO LABELING FROM PROSPECTIVE, RANDOMIZED, OPEN-LABEL, BLIND EVALUATOR (PROBE) STUDY EVALUATING THE EFFICACY AND SAFETY OF LOW MOLECULAR WEIGHT HEPARIN/EDOXABAN VERSUS DALTEPARIN IN VENOUS THROMBOEMBOLISM ASSOCIATED WITH CANCER |
EQ 60MG BASE | SAVAYSA | DAIICHI SANKYO INC | N206316 | Jan. 8, 2015 | RX | TABLET | ORAL | Aug. 9, 2022 | INFORMATION ADDED TO LABELING FROM PROSPECTIVE, RANDOMIZED, OPEN-LABEL, BLIND EVALUATOR (PROBE) STUDY EVALUATING THE EFFICACY AND SAFETY OF LOW MOLECULAR WEIGHT HEPARIN/EDOXABAN VERSUS DALTEPARIN IN VENOUS THROMBOEMBOLISM ASSOCIATED WITH CANCER |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Coagulation factor X | Enzyme | INHIBITOR | Ki | 9.25 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
ID | Source |
---|---|
D09546 | KEGG_DRUG |
480449-71-6 | SECONDARY_CAS_RN |
4034081 | VANDF |
CHEBI:85974 | CHEBI |
CHEMBL1269025 | ChEMBL_ID |
CHEMBL2105682 | ChEMBL_ID |
C552171 | MESH_SUPPLEMENTAL_RECORD_UI |
7575 | IUPHAR_LIGAND_ID |
8982 | INN_ID |
DB09075 | DRUGBANK_ID |
NDU3J18APO | UNII |
10280735 | PUBCHEM_CID |
1599538 | RXNORM |
232451 | MMSL |
30841 | MMSL |
30865 | MMSL |
d08338 | MMSL |
015852 | NDDF |
015853 | NDDF |
1162278009 | SNOMEDCT_US |
712778008 | SNOMEDCT_US |
714687009 | SNOMEDCT_US |
C2975435 | UMLSCUI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
SAVAYSA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65597-201 | TABLET, FILM COATED | 15 mg | ORAL | NDA | 34 sections |
SAVAYSA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65597-202 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 34 sections |
SAVAYSA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65597-203 | TABLET, FILM COATED | 60 mg | ORAL | NDA | 34 sections |