Stem definition | Drug id | CAS RN |
---|---|---|
beta-adrenoreceptor antagonists | 1786 | 51384-51-1 |
Dose | Unit | Route |
---|---|---|
0.15 | g | O |
0.15 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 1000 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 24.95 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 38 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 13 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.88 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 3.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 7, 1978 | FDA | US PHARMS HOLDINGS I |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myocardial infarction | 889.78 | 9.79 | 1786 | 257450 | 95742 | 46331084 |
Cardiac failure congestive | 679.48 | 9.79 | 1544 | 257692 | 90206 | 46336620 |
Atrial fibrillation | 639.95 | 9.79 | 1625 | 257611 | 101965 | 46324861 |
Coronary artery disease | 483.65 | 9.79 | 754 | 258482 | 32998 | 46393828 |
Rheumatoid arthritis | 450.18 | 9.79 | 403 | 258833 | 239812 | 46187014 |
Drug ineffective | 402.65 | 9.79 | 2172 | 257064 | 675666 | 45751160 |
Bradycardia | 394.59 | 9.79 | 1026 | 258210 | 65272 | 46361554 |
Acute myocardial infarction | 367.06 | 9.79 | 646 | 258590 | 31278 | 46395548 |
Cerebrovascular accident | 245.06 | 9.79 | 1161 | 258075 | 99878 | 46326948 |
Completed suicide | 233.13 | 9.79 | 1497 | 257739 | 144423 | 46282403 |
Contraindicated product administered | 220.33 | 9.79 | 84 | 259152 | 79863 | 46346963 |
Synovitis | 213.81 | 9.79 | 40 | 259196 | 61035 | 46365791 |
Pemphigus | 197.07 | 9.79 | 14 | 259222 | 45260 | 46381566 |
Hypotension | 193.99 | 9.79 | 2059 | 257177 | 230530 | 46196296 |
Treatment failure | 186.58 | 9.79 | 146 | 259090 | 92941 | 46333885 |
Drug intolerance | 184.41 | 9.79 | 334 | 258902 | 146715 | 46280111 |
Systemic lupus erythematosus | 162.85 | 9.79 | 79 | 259157 | 65101 | 46361725 |
Off label use | 159.28 | 9.79 | 1347 | 257889 | 378494 | 46048332 |
Product prescribing error | 158.95 | 9.79 | 347 | 258889 | 19700 | 46407126 |
Coronary artery bypass | 157.28 | 9.79 | 121 | 259115 | 2324 | 46424502 |
Hand deformity | 149.59 | 9.79 | 11 | 259225 | 34563 | 46392263 |
Infusion related reaction | 145.51 | 9.79 | 210 | 259026 | 100998 | 46325828 |
Dizziness | 132.96 | 9.79 | 2639 | 256597 | 337775 | 46089051 |
Cardiogenic shock | 132.63 | 9.79 | 286 | 258950 | 16098 | 46410728 |
Syncope | 132.48 | 9.79 | 1016 | 258220 | 103787 | 46323039 |
Abortion spontaneous | 130.37 | 9.79 | 40 | 259196 | 43606 | 46383220 |
General physical health deterioration | 129.32 | 9.79 | 1091 | 258145 | 114678 | 46312148 |
Angina pectoris | 126.31 | 9.79 | 381 | 258855 | 26394 | 46400432 |
Gastrointestinal haemorrhage | 121.07 | 9.79 | 790 | 258446 | 76583 | 46350243 |
Coronary arterial stent insertion | 120.96 | 9.79 | 111 | 259125 | 2742 | 46424084 |
Lower respiratory tract infection | 112.14 | 9.79 | 85 | 259151 | 55004 | 46371822 |
Drug hypersensitivity | 111.54 | 9.79 | 844 | 258392 | 242981 | 46183845 |
Sinus bradycardia | 110.90 | 9.79 | 240 | 258996 | 13542 | 46413284 |
Glossodynia | 110.50 | 9.79 | 54 | 259182 | 44319 | 46382507 |
Joint swelling | 108.64 | 9.79 | 513 | 258723 | 165560 | 46261266 |
Angina unstable | 107.19 | 9.79 | 168 | 259068 | 7380 | 46419446 |
Cardiac disorder | 105.51 | 9.79 | 503 | 258733 | 43355 | 46383471 |
Pyrexia | 104.63 | 9.79 | 1338 | 257898 | 347464 | 46079362 |
Palpitations | 104.39 | 9.79 | 894 | 258342 | 94365 | 46332461 |
Exposure during pregnancy | 99.07 | 9.79 | 291 | 258945 | 107921 | 46318905 |
Arrhythmia | 98.36 | 9.79 | 419 | 258817 | 34422 | 46392404 |
Febrile neutropenia | 98.32 | 9.79 | 239 | 258997 | 94388 | 46332438 |
Therapeutic product effect decreased | 97.01 | 9.79 | 195 | 259041 | 82406 | 46344420 |
Rheumatoid factor positive | 96.25 | 9.79 | 4 | 259232 | 20457 | 46406369 |
Dyspnoea | 95.85 | 9.79 | 3630 | 255606 | 511918 | 45914908 |
Fall | 95.30 | 9.79 | 2446 | 256790 | 326651 | 46100175 |
International normalised ratio increased | 94.76 | 9.79 | 512 | 258724 | 46371 | 46380455 |
Hypertension | 92.83 | 9.79 | 1569 | 257667 | 194787 | 46232039 |
Drug abuse | 92.66 | 9.79 | 130 | 259106 | 63278 | 46363548 |
Rash | 91.48 | 9.79 | 1411 | 257825 | 355101 | 46071725 |
Arthropathy | 89.52 | 9.79 | 212 | 259024 | 84488 | 46342338 |
Maternal exposure during pregnancy | 88.72 | 9.79 | 283 | 258953 | 102266 | 46324560 |
Hypersensitivity | 85.53 | 9.79 | 487 | 258749 | 149834 | 46276992 |
Ventricular tachycardia | 85.32 | 9.79 | 247 | 258989 | 16720 | 46410106 |
Neutropenia | 85.27 | 9.79 | 457 | 258779 | 142747 | 46284079 |
Pregnancy | 84.48 | 9.79 | 23 | 259213 | 27114 | 46399712 |
Device expulsion | 79.14 | 9.79 | 27 | 259209 | 27515 | 46399311 |
Pain | 79.05 | 9.79 | 2031 | 257205 | 474917 | 45951909 |
C-reactive protein abnormal | 78.69 | 9.79 | 12 | 259224 | 21258 | 46405568 |
Blood pressure inadequately controlled | 78.34 | 9.79 | 109 | 259127 | 4297 | 46422529 |
Renal failure | 75.02 | 9.79 | 962 | 258274 | 112632 | 46314194 |
Asthma | 72.13 | 9.79 | 263 | 258973 | 91279 | 46335547 |
Blood pressure increased | 71.13 | 9.79 | 1042 | 258194 | 125624 | 46301202 |
Arthralgia | 70.81 | 9.79 | 1515 | 257721 | 363088 | 46063738 |
Interstitial lung disease | 70.77 | 9.79 | 119 | 259117 | 53830 | 46372996 |
Haematochezia | 68.82 | 9.79 | 399 | 258837 | 37094 | 46389732 |
Blood loss anaemia | 67.69 | 9.79 | 148 | 259088 | 8409 | 46418417 |
Medication error | 63.42 | 9.79 | 339 | 258897 | 30572 | 46396254 |
Asthenia | 62.86 | 9.79 | 2212 | 257024 | 308863 | 46117963 |
Therapeutic drug monitoring analysis not performed | 62.29 | 9.79 | 37 | 259199 | 453 | 46426373 |
Suicidal ideation | 62.09 | 9.79 | 138 | 259098 | 56244 | 46370582 |
Nodal rhythm | 61.52 | 9.79 | 61 | 259175 | 1664 | 46425162 |
Product monitoring error | 61.48 | 9.79 | 65 | 259171 | 1916 | 46424910 |
Pericarditis | 61.28 | 9.79 | 28 | 259208 | 23899 | 46402927 |
Dehydration | 59.78 | 9.79 | 1230 | 258006 | 158310 | 46268516 |
Oedema peripheral | 59.42 | 9.79 | 1230 | 258006 | 158476 | 46268350 |
Product use issue | 59.14 | 9.79 | 297 | 258939 | 94347 | 46332479 |
Hypertensive crisis | 58.89 | 9.79 | 188 | 259048 | 13427 | 46413399 |
Cardiac failure | 57.91 | 9.79 | 689 | 258547 | 79259 | 46347567 |
Chest pain | 57.65 | 9.79 | 1333 | 257903 | 174991 | 46251835 |
Cardiac arrest | 57.33 | 9.79 | 760 | 258476 | 89639 | 46337187 |
Hepatic function abnormal | 56.06 | 9.79 | 65 | 259171 | 34356 | 46392470 |
Drug resistance | 55.44 | 9.79 | 14 | 259222 | 17354 | 46409472 |
Swelling | 54.95 | 9.79 | 435 | 258801 | 124076 | 46302750 |
Pulmonary oedema | 54.05 | 9.79 | 476 | 258760 | 50629 | 46376197 |
Atrial flutter | 53.76 | 9.79 | 141 | 259095 | 9007 | 46417819 |
Hypertensive emergency | 53.64 | 9.79 | 55 | 259181 | 1563 | 46425263 |
Pulmonary renal syndrome | 53.52 | 9.79 | 31 | 259205 | 361 | 46426465 |
Drug reaction with eosinophilia and systemic symptoms | 53.51 | 9.79 | 51 | 259185 | 29497 | 46397329 |
Headache | 53.19 | 9.79 | 2145 | 257091 | 476207 | 45950619 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 52.23 | 9.79 | 59 | 259177 | 1876 | 46424950 |
Coronary artery occlusion | 50.84 | 9.79 | 128 | 259108 | 7974 | 46418852 |
Product substitution issue | 50.61 | 9.79 | 191 | 259045 | 14840 | 46411986 |
Blood creatinine increased | 49.98 | 9.79 | 646 | 258590 | 75757 | 46351069 |
Haemoglobin decreased | 48.89 | 9.79 | 996 | 258240 | 127953 | 46298873 |
Infection | 47.91 | 9.79 | 492 | 258744 | 133100 | 46293726 |
Hepatocellular injury | 47.80 | 9.79 | 56 | 259180 | 29466 | 46397360 |
C-reactive protein increased | 47.69 | 9.79 | 166 | 259070 | 58424 | 46368402 |
Erythema | 47.20 | 9.79 | 536 | 258700 | 142284 | 46284542 |
Myocardial ischaemia | 44.59 | 9.79 | 164 | 259072 | 12585 | 46414241 |
Product use in unapproved indication | 44.31 | 9.79 | 306 | 258930 | 89967 | 46336859 |
Lower gastrointestinal haemorrhage | 44.22 | 9.79 | 114 | 259122 | 7206 | 46419620 |
Ventricular fibrillation | 43.72 | 9.79 | 152 | 259084 | 11344 | 46415482 |
Orthostatic intolerance | 43.38 | 9.79 | 42 | 259194 | 1112 | 46425714 |
Injection site pain | 42.92 | 9.79 | 384 | 258852 | 106768 | 46320058 |
Chronic kidney disease | 42.87 | 9.79 | 380 | 258856 | 40491 | 46386335 |
Abortion induced | 42.35 | 9.79 | 4 | 259232 | 10256 | 46416570 |
Anaphylactic reaction | 40.90 | 9.79 | 154 | 259082 | 52958 | 46373868 |
BRASH syndrome | 40.76 | 9.79 | 17 | 259219 | 89 | 46426737 |
Infective pulmonary exacerbation of cystic fibrosis | 40.20 | 9.79 | 6 | 259230 | 10801 | 46416025 |
Mental status changes | 39.88 | 9.79 | 354 | 258882 | 37734 | 46389092 |
Sinusitis | 38.68 | 9.79 | 498 | 258738 | 129270 | 46297556 |
Toxicity to various agents | 38.37 | 9.79 | 1488 | 257748 | 210278 | 46216548 |
Hepatic enzyme increased | 38.31 | 9.79 | 281 | 258955 | 81506 | 46345320 |
Bone erosion | 38.15 | 9.79 | 4 | 259232 | 9439 | 46417387 |
Unresponsive to stimuli | 37.89 | 9.79 | 307 | 258929 | 31867 | 46394959 |
Peripheral arterial occlusive disease | 36.89 | 9.79 | 71 | 259165 | 3681 | 46423145 |
Duodenal ulcer perforation | 35.95 | 9.79 | 3 | 259233 | 8499 | 46418327 |
Pulmonary hypertension | 35.88 | 9.79 | 331 | 258905 | 35662 | 46391164 |
Intestinal malrotation | 35.84 | 9.79 | 23 | 259213 | 326 | 46426500 |
Pneumocystis jirovecii pneumonia | 35.82 | 9.79 | 20 | 259216 | 15228 | 46411598 |
Congenital hydronephrosis | 35.18 | 9.79 | 24 | 259212 | 379 | 46426447 |
Sopor | 35.00 | 9.79 | 35 | 259201 | 19793 | 46407033 |
Heart rate irregular | 34.86 | 9.79 | 199 | 259037 | 18392 | 46408434 |
Intentional self-injury | 34.84 | 9.79 | 50 | 259186 | 24116 | 46402710 |
Full blood count decreased | 34.84 | 9.79 | 227 | 259009 | 21984 | 46404842 |
Transient ischaemic attack | 34.81 | 9.79 | 321 | 258915 | 34582 | 46392244 |
Inflammation | 34.67 | 9.79 | 146 | 259090 | 48635 | 46378191 |
Red blood cell sedimentation rate increased | 34.36 | 9.79 | 46 | 259190 | 22843 | 46403983 |
Drug interaction | 34.21 | 9.79 | 1416 | 257820 | 201678 | 46225148 |
Atrioventricular block | 34.09 | 9.79 | 99 | 259137 | 6712 | 46420114 |
Alopecia | 34.05 | 9.79 | 666 | 258570 | 161748 | 46265078 |
Migraine | 34.05 | 9.79 | 238 | 258998 | 69788 | 46357038 |
Heart rate increased | 33.94 | 9.79 | 594 | 258642 | 74197 | 46352629 |
Nephrogenic systemic fibrosis | 33.80 | 9.79 | 79 | 259157 | 4693 | 46422133 |
Acute kidney injury | 33.51 | 9.79 | 1616 | 257620 | 234239 | 46192587 |
Heart rate decreased | 33.29 | 9.79 | 295 | 258941 | 31428 | 46395398 |
Bone marrow failure | 33.17 | 9.79 | 72 | 259164 | 29597 | 46397229 |
Decorticate posture | 32.77 | 9.79 | 22 | 259214 | 338 | 46426488 |
Haemophagocytic lymphohistiocytosis | 32.53 | 9.79 | 4 | 259232 | 8338 | 46418488 |
Myocardial depression | 32.37 | 9.79 | 25 | 259211 | 483 | 46426343 |
Therapeutic product effect incomplete | 32.21 | 9.79 | 278 | 258958 | 77875 | 46348951 |
Congenital aortic valve stenosis | 32.15 | 9.79 | 13 | 259223 | 62 | 46426764 |
Cardiac output decreased | 32.06 | 9.79 | 32 | 259204 | 880 | 46425946 |
Vascular graft | 32.00 | 9.79 | 30 | 259206 | 762 | 46426064 |
Suspected suicide | 31.75 | 9.79 | 76 | 259160 | 4585 | 46422241 |
Renal injury | 31.10 | 9.79 | 120 | 259116 | 9421 | 46417405 |
Ischaemic stroke | 30.70 | 9.79 | 178 | 259058 | 16544 | 46410282 |
Injection site erythema | 30.56 | 9.79 | 265 | 258971 | 74162 | 46352664 |
Coronary artery stenosis | 30.14 | 9.79 | 75 | 259161 | 4638 | 46422188 |
Anaemia | 29.98 | 9.79 | 1721 | 257515 | 254058 | 46172768 |
Injection site reaction | 29.96 | 9.79 | 150 | 259086 | 47699 | 46379127 |
Lactic acidosis | 29.95 | 9.79 | 304 | 258932 | 33605 | 46393221 |
Tachyarrhythmia | 29.93 | 9.79 | 74 | 259162 | 4558 | 46422268 |
Cytomegalovirus infection | 29.82 | 9.79 | 34 | 259202 | 18110 | 46408716 |
Acute coronary syndrome | 29.79 | 9.79 | 124 | 259112 | 10080 | 46416746 |
Thrombosis | 29.78 | 9.79 | 457 | 258779 | 55612 | 46371214 |
Device dislocation | 29.60 | 9.79 | 47 | 259189 | 21755 | 46405071 |
Atrioventricular block complete | 29.14 | 9.79 | 101 | 259135 | 7526 | 46419300 |
Death | 28.97 | 9.79 | 2200 | 257036 | 333348 | 46093478 |
Supraventricular tachycardia | 28.91 | 9.79 | 148 | 259088 | 13122 | 46413704 |
Hypothermia | 28.76 | 9.79 | 139 | 259097 | 12044 | 46414782 |
Lymphocyte count decreased | 28.68 | 9.79 | 62 | 259174 | 25527 | 46401299 |
Internal haemorrhage | 28.60 | 9.79 | 71 | 259165 | 4384 | 46422442 |
Mitral valve incompetence | 28.56 | 9.79 | 191 | 259045 | 18661 | 46408165 |
Cardiac failure acute | 28.32 | 9.79 | 104 | 259132 | 7974 | 46418852 |
Drug eruption | 28.01 | 9.79 | 47 | 259189 | 21282 | 46405544 |
Neutrophil count decreased | 27.85 | 9.79 | 135 | 259101 | 43291 | 46383535 |
Neutropenic sepsis | 27.76 | 9.79 | 17 | 259219 | 12307 | 46414519 |
Skin induration | 27.69 | 9.79 | 55 | 259181 | 2919 | 46423907 |
Hip arthroplasty | 27.60 | 9.79 | 36 | 259200 | 18076 | 46408750 |
Conjoined twins | 27.58 | 9.79 | 18 | 259218 | 263 | 46426563 |
Acute generalised exanthematous pustulosis | 27.40 | 9.79 | 9 | 259227 | 9396 | 46417430 |
Urticaria | 27.33 | 9.79 | 475 | 258761 | 117417 | 46309409 |
Abdominal discomfort | 27.27 | 9.79 | 635 | 258601 | 150530 | 46276296 |
Mucosal inflammation | 26.87 | 9.79 | 118 | 259118 | 38858 | 46387968 |
Presyncope | 26.49 | 9.79 | 229 | 259007 | 24225 | 46402601 |
Device difficult to use | 26.43 | 9.79 | 6 | 259230 | 7998 | 46418828 |
Hyperkalaemia | 26.43 | 9.79 | 412 | 258824 | 50297 | 46376529 |
Musculoskeletal stiffness | 26.34 | 9.79 | 384 | 258852 | 97609 | 46329217 |
Device capturing issue | 26.32 | 9.79 | 10 | 259226 | 39 | 46426787 |
Acute respiratory failure | 26.10 | 9.79 | 262 | 258974 | 28876 | 46397950 |
Ventricular extrasystoles | 25.95 | 9.79 | 126 | 259110 | 10937 | 46415889 |
Renal impairment neonatal | 25.58 | 9.79 | 8 | 259228 | 14 | 46426812 |
Acute left ventricular failure | 25.53 | 9.79 | 27 | 259209 | 796 | 46426030 |
Allergic reaction to excipient | 25.51 | 9.79 | 18 | 259218 | 301 | 46426525 |
Condition aggravated | 25.40 | 9.79 | 1107 | 258129 | 243945 | 46182881 |
Helicobacter infection | 25.33 | 9.79 | 17 | 259219 | 11719 | 46415107 |
Schizophrenia | 25.32 | 9.79 | 8 | 259228 | 8560 | 46418266 |
Electrocardiogram T wave abnormal | 25.06 | 9.79 | 46 | 259190 | 2300 | 46424526 |
Cholestasis | 24.82 | 9.79 | 72 | 259164 | 26821 | 46400005 |
Rash maculo-papular | 24.73 | 9.79 | 76 | 259160 | 27798 | 46399028 |
Dystonia | 24.71 | 9.79 | 16 | 259220 | 11241 | 46415585 |
Atrioventricular block first degree | 24.58 | 9.79 | 83 | 259153 | 6103 | 46420723 |
Listless | 24.44 | 9.79 | 42 | 259194 | 1993 | 46424833 |
Cerebral haemorrhage | 24.41 | 9.79 | 253 | 258983 | 28118 | 46398708 |
Colitis ulcerative | 24.29 | 9.79 | 38 | 259198 | 17694 | 46409132 |
Arterial haemorrhage | 24.06 | 9.79 | 38 | 259198 | 1680 | 46425146 |
Diverticulum intestinal haemorrhagic | 23.99 | 9.79 | 32 | 259204 | 1211 | 46425615 |
Renal impairment | 23.87 | 9.79 | 561 | 258675 | 73811 | 46353015 |
Product administration error | 23.83 | 9.79 | 189 | 259047 | 19492 | 46407334 |
Cardiac pacemaker insertion | 23.80 | 9.79 | 59 | 259177 | 3640 | 46423186 |
Bradyarrhythmia | 23.57 | 9.79 | 41 | 259195 | 1965 | 46424861 |
Gastrointestinal tract mucosal pigmentation | 23.49 | 9.79 | 22 | 259214 | 558 | 46426268 |
Amenorrhoea | 23.42 | 9.79 | 10 | 259226 | 8885 | 46417941 |
Phaeochromocytoma crisis | 23.39 | 9.79 | 14 | 259222 | 174 | 46426652 |
Nodal arrhythmia | 23.20 | 9.79 | 32 | 259204 | 1251 | 46425575 |
Atrial tachycardia | 23.20 | 9.79 | 42 | 259194 | 2078 | 46424748 |
Hypertensive heart disease | 23.19 | 9.79 | 47 | 259189 | 2531 | 46424295 |
Hepatitis | 23.15 | 9.79 | 96 | 259140 | 32119 | 46394707 |
Vitello-intestinal duct remnant | 22.94 | 9.79 | 9 | 259227 | 39 | 46426787 |
Arteriosclerosis | 22.94 | 9.79 | 111 | 259125 | 9622 | 46417204 |
Gout | 22.92 | 9.79 | 124 | 259112 | 11232 | 46415594 |
Ischaemic cardiomyopathy | 22.79 | 9.79 | 47 | 259189 | 2563 | 46424263 |
Lymphopenia | 22.69 | 9.79 | 31 | 259205 | 15262 | 46411564 |
Acne | 22.54 | 9.79 | 48 | 259188 | 19871 | 46406955 |
Coma | 22.53 | 9.79 | 211 | 259025 | 58138 | 46368688 |
Intraventricular haemorrhage | 22.47 | 9.79 | 39 | 259197 | 1866 | 46424960 |
Progressive multifocal leukoencephalopathy | 22.46 | 9.79 | 18 | 259218 | 11328 | 46415498 |
Aortic valve stenosis | 22.44 | 9.79 | 52 | 259184 | 3072 | 46423754 |
Loss of employment | 22.22 | 9.79 | 31 | 259205 | 1225 | 46425601 |
Non-cardiogenic pulmonary oedema | 22.09 | 9.79 | 21 | 259215 | 543 | 46426283 |
Torsade de pointes | 22.07 | 9.79 | 129 | 259107 | 12025 | 46414801 |
Liver disorder | 22.06 | 9.79 | 119 | 259117 | 37127 | 46389699 |
Troponin increased | 22.05 | 9.79 | 94 | 259142 | 7722 | 46419104 |
Labile hypertension | 22.00 | 9.79 | 20 | 259216 | 488 | 46426338 |
Hip fracture | 21.99 | 9.79 | 235 | 259001 | 26321 | 46400505 |
Loss of personal independence in daily activities | 21.99 | 9.79 | 207 | 259029 | 56976 | 46369850 |
Congenital choroid plexus cyst | 21.96 | 9.79 | 16 | 259220 | 282 | 46426544 |
Vascular resistance pulmonary decreased | 21.59 | 9.79 | 10 | 259226 | 70 | 46426756 |
Vomiting | 21.52 | 9.79 | 2194 | 257042 | 450600 | 45976226 |
Diarrhoea | 21.43 | 9.79 | 3477 | 255759 | 556125 | 45870701 |
Ventricular arrhythmia | 21.42 | 9.79 | 54 | 259182 | 3367 | 46423459 |
Product solubility abnormal | 21.35 | 9.79 | 25 | 259211 | 827 | 46425999 |
Myxoedema coma | 21.31 | 9.79 | 18 | 259218 | 397 | 46426429 |
CD30 expression | 21.29 | 9.79 | 8 | 259228 | 30 | 46426796 |
Hyperthermia | 21.12 | 9.79 | 9 | 259227 | 8005 | 46418821 |
Ventricular hypokinesia | 21.11 | 9.79 | 60 | 259176 | 4018 | 46422808 |
Haematoma | 21.04 | 9.79 | 270 | 258966 | 31602 | 46395224 |
Hypomagnesaemia | 21.01 | 9.79 | 202 | 259034 | 22008 | 46404818 |
Heparin-induced thrombocytopenia | 20.96 | 9.79 | 62 | 259174 | 4247 | 46422579 |
Rheumatoid nodule | 20.94 | 9.79 | 12 | 259224 | 9008 | 46417818 |
Atrial septal defect | 20.93 | 9.79 | 80 | 259156 | 6252 | 46420574 |
Chloropsia | 20.89 | 9.79 | 8 | 259228 | 32 | 46426794 |
Congenital bladder anomaly | 20.64 | 9.79 | 13 | 259223 | 178 | 46426648 |
Epistaxis | 20.62 | 9.79 | 485 | 258751 | 63820 | 46363006 |
Haemarthrosis | 20.60 | 9.79 | 49 | 259187 | 2944 | 46423882 |
Body height decreased | 20.58 | 9.79 | 107 | 259129 | 9545 | 46417281 |
Rectourethral fistula | 20.52 | 9.79 | 8 | 259228 | 34 | 46426792 |
Urachal abnormality | 20.39 | 9.79 | 13 | 259223 | 182 | 46426644 |
Osmolar gap increased | 20.31 | 9.79 | 7 | 259229 | 19 | 46426807 |
Subchondral insufficiency fracture | 20.31 | 9.79 | 9 | 259227 | 56 | 46426770 |
Atrial thrombosis | 20.31 | 9.79 | 32 | 259204 | 1412 | 46425414 |
Therapeutic response decreased | 20.31 | 9.79 | 148 | 259088 | 42997 | 46383829 |
Cerebrospinal fluid retention | 20.25 | 9.79 | 10 | 259226 | 82 | 46426744 |
Bicuspid aortic valve | 20.17 | 9.79 | 11 | 259225 | 113 | 46426713 |
Tendonitis | 20.13 | 9.79 | 30 | 259206 | 14247 | 46412579 |
Seizure | 19.99 | 9.79 | 525 | 258711 | 122529 | 46304297 |
Anuria | 19.90 | 9.79 | 120 | 259116 | 11311 | 46415515 |
Glomerular filtration rate decreased | 19.88 | 9.79 | 122 | 259114 | 11572 | 46415254 |
Sudden cardiac death | 19.73 | 9.79 | 40 | 259196 | 2155 | 46424671 |
Fryns syndrome | 19.55 | 9.79 | 9 | 259227 | 62 | 46426764 |
Blue toe syndrome | 19.48 | 9.79 | 16 | 259220 | 339 | 46426487 |
Mood swings | 19.38 | 9.79 | 38 | 259198 | 16214 | 46410612 |
Persistent cloaca | 19.35 | 9.79 | 13 | 259223 | 200 | 46426626 |
Mouth ulceration | 19.25 | 9.79 | 80 | 259156 | 26752 | 46400074 |
Cardiac ablation | 19.25 | 9.79 | 29 | 259207 | 1230 | 46425596 |
Alanine aminotransferase increased | 19.04 | 9.79 | 361 | 258875 | 88090 | 46338736 |
Dyspnoea exertional | 18.89 | 9.79 | 388 | 258848 | 49901 | 46376925 |
Splenic rupture | 18.74 | 9.79 | 28 | 259208 | 1179 | 46425647 |
Agranulocytosis | 18.63 | 9.79 | 62 | 259174 | 22123 | 46404703 |
Aortic valve incompetence | 18.58 | 9.79 | 74 | 259162 | 5896 | 46420930 |
Pharyngitis | 18.57 | 9.79 | 44 | 259192 | 17539 | 46409287 |
Wrong product administered | 18.51 | 9.79 | 71 | 259165 | 5559 | 46421267 |
Embolic cerebral infarction | 18.42 | 9.79 | 18 | 259218 | 482 | 46426344 |
Angioedema | 18.40 | 9.79 | 314 | 258922 | 39028 | 46387798 |
Embolic stroke | 18.32 | 9.79 | 53 | 259183 | 3586 | 46423240 |
Patent ductus arteriosus | 18.25 | 9.79 | 55 | 259181 | 3807 | 46423019 |
Neurotoxicity | 18.22 | 9.79 | 30 | 259206 | 13687 | 46413139 |
Cardiomegaly | 18.05 | 9.79 | 162 | 259074 | 17320 | 46409506 |
Device stimulation issue | 17.91 | 9.79 | 9 | 259227 | 77 | 46426749 |
Malignant polyp | 17.89 | 9.79 | 12 | 259224 | 184 | 46426642 |
Atrioventricular block second degree | 17.85 | 9.79 | 54 | 259182 | 3745 | 46423081 |
Ultrasound kidney abnormal | 17.72 | 9.79 | 7 | 259229 | 31 | 46426795 |
Hepatotoxicity | 17.67 | 9.79 | 75 | 259161 | 24934 | 46401892 |
Ovarian cyst | 17.62 | 9.79 | 32 | 259204 | 14055 | 46412771 |
Malignant neoplasm progression | 17.59 | 9.79 | 254 | 258982 | 64672 | 46362154 |
End stage renal disease | 17.55 | 9.79 | 72 | 259164 | 5814 | 46421012 |
Epilepsy | 17.52 | 9.79 | 70 | 259166 | 23668 | 46403158 |
Drug therapeutic incompatibility | 17.51 | 9.79 | 8 | 259228 | 54 | 46426772 |
Toxic skin eruption | 17.49 | 9.79 | 26 | 259210 | 12361 | 46414465 |
Neutrophil function disorder | 17.49 | 9.79 | 6 | 259230 | 16 | 46426810 |
Metastases to bone | 17.46 | 9.79 | 45 | 259191 | 17431 | 46409395 |
Blood pressure abnormal | 17.45 | 9.79 | 122 | 259114 | 12095 | 46414731 |
Live birth | 17.37 | 9.79 | 19 | 259217 | 10311 | 46416515 |
Left-to-right cardiac shunt | 17.22 | 9.79 | 10 | 259226 | 117 | 46426709 |
Blood potassium decreased | 17.15 | 9.79 | 302 | 258934 | 37761 | 46389065 |
Mobility decreased | 17.14 | 9.79 | 235 | 259001 | 60359 | 46366467 |
Tuberculosis | 17.13 | 9.79 | 19 | 259217 | 10246 | 46416580 |
Product dose omission issue | 17.12 | 9.79 | 1120 | 258116 | 167400 | 46259426 |
Immunodeficiency | 17.10 | 9.79 | 29 | 259207 | 13077 | 46413749 |
Post procedural haemorrhage | 17.01 | 9.79 | 84 | 259152 | 7342 | 46419484 |
Labelled drug-drug interaction medication error | 16.99 | 9.79 | 97 | 259139 | 8964 | 46417862 |
Serotonin syndrome | 16.89 | 9.79 | 73 | 259163 | 24147 | 46402679 |
Coronary artery dissection | 16.88 | 9.79 | 20 | 259216 | 670 | 46426156 |
Cardioversion | 16.86 | 9.79 | 26 | 259210 | 1126 | 46425700 |
Negative cardiac inotropic effect | 16.80 | 9.79 | 4 | 259232 | 0 | 46426826 |
Adrenalectomy | 16.80 | 9.79 | 4 | 259232 | 0 | 46426826 |
Pulmonary tuberculosis | 16.76 | 9.79 | 3 | 259233 | 4728 | 46422098 |
Cardioactive drug level increased | 16.73 | 9.79 | 36 | 259200 | 2023 | 46424803 |
Deep vein thrombosis | 16.72 | 9.79 | 570 | 258666 | 79203 | 46347623 |
Hyperammonaemia | 16.69 | 9.79 | 3 | 259233 | 4713 | 46422113 |
Abdominal pain | 16.68 | 9.79 | 1077 | 258159 | 228954 | 46197872 |
Fluid retention | 16.67 | 9.79 | 386 | 258850 | 50660 | 46376166 |
Congenital nail disorder | 16.63 | 9.79 | 9 | 259227 | 91 | 46426735 |
Bundle branch block left | 16.56 | 9.79 | 75 | 259161 | 6324 | 46420502 |
Diverticulum intestinal | 16.54 | 9.79 | 72 | 259164 | 5969 | 46420857 |
Coagulopathy | 16.40 | 9.79 | 166 | 259070 | 18333 | 46408493 |
Injection site swelling | 16.36 | 9.79 | 144 | 259092 | 40183 | 46386643 |
Eructation | 16.34 | 9.79 | 82 | 259154 | 7213 | 46419613 |
Arteriovenous fistula occlusion | 16.34 | 9.79 | 14 | 259222 | 315 | 46426511 |
Blood glucose increased | 16.23 | 9.79 | 519 | 258717 | 71494 | 46355332 |
Osteonecrosis of jaw | 16.19 | 9.79 | 118 | 259118 | 34284 | 46392542 |
Congenital acrochordon | 16.16 | 9.79 | 8 | 259228 | 66 | 46426760 |
Sinus arrest | 16.10 | 9.79 | 32 | 259204 | 1699 | 46425127 |
Septic shock | 15.85 | 9.79 | 226 | 259010 | 57667 | 46369159 |
Cardiovascular disorder | 15.85 | 9.79 | 119 | 259117 | 12068 | 46414758 |
Neonatal respiratory failure | 15.84 | 9.79 | 11 | 259225 | 179 | 46426647 |
Bronchiectasis | 15.81 | 9.79 | 17 | 259219 | 9299 | 46417527 |
Immune reconstitution inflammatory syndrome | 15.79 | 9.79 | 6 | 259230 | 5719 | 46421107 |
Photophobia | 15.68 | 9.79 | 36 | 259200 | 14508 | 46412318 |
Pathogen resistance | 15.66 | 9.79 | 7 | 259229 | 6053 | 46420773 |
Pregnancy with contraceptive device | 15.64 | 9.79 | 3 | 259233 | 4500 | 46422326 |
Cardiomyopathy | 15.61 | 9.79 | 147 | 259089 | 15926 | 46410900 |
Ageusia | 15.48 | 9.79 | 113 | 259123 | 11359 | 46415467 |
Gastrointestinal disorder | 15.47 | 9.79 | 235 | 259001 | 59341 | 46367485 |
Haematuria | 15.46 | 9.79 | 222 | 259014 | 26636 | 46400190 |
Traumatic haemorrhage | 15.40 | 9.79 | 15 | 259221 | 400 | 46426426 |
Skin hypertrophy | 15.36 | 9.79 | 45 | 259191 | 3066 | 46423760 |
Disseminated intravascular coagulation | 15.36 | 9.79 | 54 | 259182 | 18951 | 46407875 |
Leukopenia | 15.31 | 9.79 | 277 | 258959 | 68066 | 46358760 |
Orthopnoea | 15.28 | 9.79 | 69 | 259167 | 5811 | 46421015 |
Eosinophilia | 15.26 | 9.79 | 55 | 259181 | 19162 | 46407664 |
Pruritus | 15.21 | 9.79 | 1149 | 258087 | 241203 | 46185623 |
Respiratory disorder | 15.20 | 9.79 | 89 | 259147 | 27211 | 46399615 |
Blood pressure decreased | 15.06 | 9.79 | 420 | 258816 | 56739 | 46370087 |
Congenital diaphragmatic hernia | 15.00 | 9.79 | 11 | 259225 | 196 | 46426630 |
Tachycardia induced cardiomyopathy | 14.99 | 9.79 | 7 | 259229 | 50 | 46426776 |
Body temperature increased | 14.96 | 9.79 | 79 | 259157 | 24782 | 46402044 |
Renal dysplasia | 14.93 | 9.79 | 10 | 259226 | 153 | 46426673 |
Urogenital haemorrhage | 14.93 | 9.79 | 10 | 259226 | 153 | 46426673 |
International normalised ratio decreased | 14.85 | 9.79 | 57 | 259179 | 4463 | 46422363 |
Sinus node dysfunction | 14.85 | 9.79 | 55 | 259181 | 4234 | 46422592 |
Hypocapnia | 14.83 | 9.79 | 14 | 259222 | 359 | 46426467 |
Injection site pruritus | 14.80 | 9.79 | 145 | 259091 | 39598 | 46387228 |
Pleural effusion | 14.78 | 9.79 | 582 | 258654 | 82370 | 46344456 |
Optic neuritis | 14.76 | 9.79 | 10 | 259226 | 6861 | 46419965 |
Alpha hydroxybutyrate dehydrogenase increased | 14.66 | 9.79 | 5 | 259231 | 13 | 46426813 |
Palmar-plantar erythrodysaesthesia syndrome | 14.66 | 9.79 | 61 | 259175 | 20390 | 46406436 |
Femur fracture | 14.62 | 9.79 | 133 | 259103 | 36864 | 46389962 |
Enterocolitis | 14.62 | 9.79 | 8 | 259228 | 6160 | 46420666 |
Cardiac valve abscess | 14.57 | 9.79 | 4 | 259232 | 3 | 46426823 |
Ischaemic hepatitis | 14.56 | 9.79 | 34 | 259202 | 2019 | 46424807 |
Urinary tract infection | 14.54 | 9.79 | 1416 | 257820 | 218850 | 46207976 |
Electrocardiogram QRS complex shortened | 14.54 | 9.79 | 14 | 259222 | 368 | 46426458 |
Arteriosclerosis coronary artery | 14.44 | 9.79 | 86 | 259150 | 8070 | 46418756 |
Oral herpes | 14.42 | 9.79 | 57 | 259179 | 19333 | 46407493 |
Epstein-Barr virus infection | 14.41 | 9.79 | 10 | 259226 | 6774 | 46420052 |
Pulseless electrical activity | 14.29 | 9.79 | 78 | 259158 | 7089 | 46419737 |
Poor venous access | 14.28 | 9.79 | 15 | 259221 | 8293 | 46418533 |
Hypovolaemia | 14.27 | 9.79 | 99 | 259137 | 9789 | 46417037 |
Drug level increased | 14.26 | 9.79 | 161 | 259075 | 18280 | 46408546 |
Aortic valve disease | 14.26 | 9.79 | 22 | 259214 | 953 | 46425873 |
Aortic stenosis | 14.19 | 9.79 | 55 | 259181 | 4327 | 46422499 |
Lymphatic fistula | 14.18 | 9.79 | 21 | 259215 | 877 | 46425949 |
Mitral valve sclerosis | 14.18 | 9.79 | 9 | 259227 | 125 | 46426701 |
Thrombin time prolonged | 14.12 | 9.79 | 8 | 259228 | 89 | 46426737 |
Stent malfunction | 14.12 | 9.79 | 7 | 259229 | 58 | 46426768 |
Panniculitis | 14.11 | 9.79 | 7 | 259229 | 5697 | 46421129 |
Femoral hernia incarcerated | 13.99 | 9.79 | 21 | 259215 | 888 | 46425938 |
Poisoning deliberate | 13.98 | 9.79 | 14 | 259222 | 7912 | 46418914 |
Heart rate abnormal | 13.95 | 9.79 | 46 | 259190 | 3341 | 46423485 |
Pallor | 13.95 | 9.79 | 193 | 259043 | 22973 | 46403853 |
Complication of device insertion | 13.94 | 9.79 | 5 | 259231 | 4939 | 46421887 |
Electrocardiogram T wave inversion | 13.82 | 9.79 | 47 | 259189 | 3469 | 46423357 |
Calciphylaxis | 13.82 | 9.79 | 38 | 259198 | 2497 | 46424329 |
Uterine perforation | 13.80 | 9.79 | 12 | 259224 | 7255 | 46419571 |
Haemorrhagic erosive gastritis | 13.78 | 9.79 | 12 | 259224 | 276 | 46426550 |
Pancreatic steatosis | 13.76 | 9.79 | 22 | 259214 | 983 | 46425843 |
Lung disorder | 13.71 | 9.79 | 164 | 259072 | 43140 | 46383686 |
Graft versus host disease | 13.61 | 9.79 | 10 | 259226 | 6578 | 46420248 |
Tooth erosion | 13.61 | 9.79 | 15 | 259221 | 464 | 46426362 |
Pulmonary hypoplasia | 13.61 | 9.79 | 12 | 259224 | 281 | 46426545 |
Body tinea | 13.54 | 9.79 | 21 | 259215 | 914 | 46425912 |
Respiratory tract infection | 13.54 | 9.79 | 104 | 259132 | 29868 | 46396958 |
Stent placement | 13.51 | 9.79 | 47 | 259189 | 3509 | 46423317 |
Aortic aneurysm | 13.50 | 9.79 | 46 | 259190 | 3398 | 46423428 |
Bronchopulmonary aspergillosis | 13.50 | 9.79 | 13 | 259223 | 7483 | 46419343 |
Oesophagitis chemical | 13.47 | 9.79 | 5 | 259231 | 18 | 46426808 |
Subarachnoid haemorrhage | 13.44 | 9.79 | 107 | 259129 | 11046 | 46415780 |
Arrhythmia neonatal | 13.44 | 9.79 | 7 | 259229 | 65 | 46426761 |
Pseudolymphoma | 13.42 | 9.79 | 17 | 259219 | 611 | 46426215 |
Menstruation irregular | 13.42 | 9.79 | 10 | 259226 | 6529 | 46420297 |
Lymphadenopathy | 13.40 | 9.79 | 120 | 259116 | 33368 | 46393458 |
Myocardial necrosis marker increased | 13.32 | 9.79 | 28 | 259208 | 1548 | 46425278 |
Extrasystoles | 13.31 | 9.79 | 58 | 259178 | 4811 | 46422015 |
Disease recurrence | 13.30 | 9.79 | 55 | 259181 | 18416 | 46408410 |
Drug dependence | 13.26 | 9.79 | 61 | 259175 | 19840 | 46406986 |
Oropharyngeal pain | 13.24 | 9.79 | 312 | 258924 | 73856 | 46352970 |
Blood urea increased | 13.21 | 9.79 | 206 | 259030 | 25146 | 46401680 |
Haemorrhage intracranial | 13.18 | 9.79 | 118 | 259118 | 12606 | 46414220 |
Cerebral ventricular rupture | 13.13 | 9.79 | 10 | 259226 | 189 | 46426637 |
Breast cancer | 13.06 | 9.79 | 176 | 259060 | 45342 | 46381484 |
Device breakage | 13.06 | 9.79 | 21 | 259215 | 9671 | 46417155 |
QRS axis abnormal | 13 | 9.79 | 22 | 259214 | 1031 | 46425795 |
Hypogammaglobulinaemia | 12.96 | 9.79 | 7 | 259229 | 5431 | 46421395 |
Ankylosing spondylitis | 12.95 | 9.79 | 11 | 259225 | 6726 | 46420100 |
Renal function test abnormal | 12.94 | 9.79 | 39 | 259197 | 2700 | 46424126 |
Gouty arthritis | 12.91 | 9.79 | 15 | 259221 | 492 | 46426334 |
Gastrointestinal toxicity | 12.88 | 9.79 | 4 | 259232 | 4327 | 46422499 |
Wound | 12.83 | 9.79 | 164 | 259072 | 42638 | 46384188 |
Generalised tonic-clonic seizure | 12.78 | 9.79 | 93 | 259143 | 27029 | 46399797 |
Fibromyalgia | 12.76 | 9.79 | 135 | 259101 | 36328 | 46390498 |
Transplant rejection | 12.73 | 9.79 | 21 | 259215 | 9575 | 46417251 |
Electrocardiogram QT interval abnormal | 12.73 | 9.79 | 9 | 259227 | 151 | 46426675 |
Hypochromic anaemia | 12.72 | 9.79 | 26 | 259210 | 1409 | 46425417 |
Electrolyte imbalance | 12.70 | 9.79 | 149 | 259087 | 17077 | 46409749 |
Carotid artery occlusion | 12.69 | 9.79 | 38 | 259198 | 2621 | 46424205 |
Depressed mood | 12.64 | 9.79 | 121 | 259115 | 33198 | 46393628 |
Ejection fraction | 12.61 | 9.79 | 16 | 259220 | 576 | 46426250 |
Neonatal anuria | 12.60 | 9.79 | 6 | 259230 | 45 | 46426781 |
Foetal renal impairment | 12.60 | 9.79 | 3 | 259233 | 0 | 46426826 |
Aortic aneurysm repair | 12.60 | 9.79 | 3 | 259233 | 0 | 46426826 |
Diabetic enteropathy | 12.60 | 9.79 | 3 | 259233 | 0 | 46426826 |
Electrocardiogram RR interval prolonged | 12.60 | 9.79 | 3 | 259233 | 0 | 46426826 |
Occult blood positive | 12.55 | 9.79 | 46 | 259190 | 3524 | 46423302 |
Herpes zoster | 12.54 | 9.79 | 284 | 258952 | 67588 | 46359238 |
Vanishing bile duct syndrome | 12.47 | 9.79 | 17 | 259219 | 657 | 46426169 |
Pericardial haemorrhage | 12.46 | 9.79 | 27 | 259209 | 1524 | 46425302 |
Cyanopsia | 12.45 | 9.79 | 4 | 259232 | 8 | 46426818 |
Antithyroid arthritis syndrome | 12.45 | 9.79 | 4 | 259232 | 8 | 46426818 |
Ventricular tachyarrhythmia | 12.43 | 9.79 | 7 | 259229 | 77 | 46426749 |
Neuroleptic malignant syndrome | 12.42 | 9.79 | 27 | 259209 | 11095 | 46415731 |
Fear | 12.42 | 9.79 | 141 | 259095 | 16031 | 46410795 |
Blood albumin abnormal | 12.42 | 9.79 | 12 | 259224 | 317 | 46426509 |
Tracheo-oesophageal fistula | 12.40 | 9.79 | 15 | 259221 | 514 | 46426312 |
Limb malformation | 12.35 | 9.79 | 14 | 259222 | 447 | 46426379 |
Congenital uterine anomaly | 12.31 | 9.79 | 8 | 259228 | 116 | 46426710 |
Gastric ulcer | 12.30 | 9.79 | 180 | 259056 | 21683 | 46405143 |
Metastases to fallopian tube | 12.28 | 9.79 | 6 | 259230 | 48 | 46426778 |
Angiocardiogram | 12.28 | 9.79 | 6 | 259230 | 48 | 46426778 |
Haemorrhage | 12.25 | 9.79 | 395 | 258841 | 54474 | 46372352 |
Diet noncompliance | 12.25 | 9.79 | 11 | 259225 | 264 | 46426562 |
Hypertensive nephropathy | 12.22 | 9.79 | 13 | 259223 | 386 | 46426440 |
Renal aplasia | 12.21 | 9.79 | 10 | 259226 | 211 | 46426615 |
Capillary disorder | 12.20 | 9.79 | 7 | 259229 | 80 | 46426746 |
Peripartum cardiomyopathy | 12.14 | 9.79 | 8 | 259228 | 119 | 46426707 |
Renal disorder | 12.12 | 9.79 | 212 | 259024 | 26474 | 46400352 |
Rash erythematous | 12.09 | 9.79 | 127 | 259109 | 34223 | 46392603 |
Folliculitis | 12.08 | 9.79 | 10 | 259226 | 6193 | 46420633 |
Splenic haemorrhage | 12.05 | 9.79 | 10 | 259226 | 215 | 46426611 |
Glucose tolerance impaired | 12.04 | 9.79 | 56 | 259180 | 4775 | 46422051 |
Mitral valve stenosis | 12.03 | 9.79 | 22 | 259214 | 1097 | 46425729 |
Foreign body | 12.03 | 9.79 | 30 | 259206 | 1858 | 46424968 |
Left ventricular hypertrophy | 11.99 | 9.79 | 57 | 259179 | 4906 | 46421920 |
Flatulence | 11.92 | 9.79 | 226 | 259010 | 28652 | 46398174 |
Subclavian artery stenosis | 11.91 | 9.79 | 8 | 259228 | 123 | 46426703 |
Irritability | 11.90 | 9.79 | 103 | 259133 | 28843 | 46397983 |
Aortic valve sclerosis | 11.86 | 9.79 | 21 | 259215 | 1021 | 46425805 |
Non-high-density lipoprotein cholesterol increased | 11.85 | 9.79 | 8 | 259228 | 124 | 46426702 |
Blood test abnormal | 11.84 | 9.79 | 92 | 259144 | 9428 | 46417398 |
Brain contusion | 11.80 | 9.79 | 15 | 259221 | 541 | 46426285 |
Glomerulonephritis rapidly progressive | 11.77 | 9.79 | 17 | 259219 | 694 | 46426132 |
Tachycardia | 11.77 | 9.79 | 671 | 258565 | 98951 | 46327875 |
Pharyngitis streptococcal | 11.74 | 9.79 | 18 | 259218 | 8450 | 46418376 |
Optic ischaemic neuropathy | 11.73 | 9.79 | 20 | 259216 | 943 | 46425883 |
Genital labial adhesions | 11.72 | 9.79 | 5 | 259231 | 28 | 46426798 |
Spinal cord haematoma | 11.69 | 9.79 | 9 | 259227 | 173 | 46426653 |
Hiatus hernia | 11.64 | 9.79 | 154 | 259082 | 18148 | 46408678 |
Decreased appetite | 11.63 | 9.79 | 1238 | 257998 | 192598 | 46234228 |
Aneurysm | 11.56 | 9.79 | 36 | 259200 | 2537 | 46424289 |
Hypoglycaemia | 11.55 | 9.79 | 389 | 258847 | 53960 | 46372866 |
Positron emission tomogram abnormal | 11.53 | 9.79 | 8 | 259228 | 130 | 46426696 |
Lacunar infarction | 11.50 | 9.79 | 44 | 259192 | 3441 | 46423385 |
Nasopharyngitis | 11.49 | 9.79 | 719 | 258517 | 153279 | 46273547 |
Therapy non-responder | 11.49 | 9.79 | 160 | 259076 | 40992 | 46385834 |
Haemorrhoidal haemorrhage | 11.49 | 9.79 | 46 | 259190 | 3674 | 46423152 |
Mydriasis | 11.47 | 9.79 | 26 | 259210 | 10527 | 46416299 |
Malignant hypertension | 11.47 | 9.79 | 21 | 259215 | 1048 | 46425778 |
Drug withdrawal syndrome | 11.46 | 9.79 | 97 | 259139 | 27287 | 46399539 |
Device use error | 11.46 | 9.79 | 7 | 259229 | 5074 | 46421752 |
Wheezing | 11.45 | 9.79 | 218 | 259018 | 53168 | 46373658 |
Haematotoxicity | 11.39 | 9.79 | 13 | 259223 | 6920 | 46419906 |
Anaphylactic shock | 11.34 | 9.79 | 66 | 259170 | 20208 | 46406618 |
Gastrointestinal arteriovenous malformation | 11.32 | 9.79 | 15 | 259221 | 564 | 46426262 |
Osteonecrosis | 11.31 | 9.79 | 90 | 259146 | 25654 | 46401172 |
Pulse absent | 11.31 | 9.79 | 56 | 259180 | 4900 | 46421926 |
Hypoaldosteronism | 11.31 | 9.79 | 9 | 259227 | 182 | 46426644 |
Fluid overload | 11.30 | 9.79 | 213 | 259023 | 26972 | 46399854 |
Demyelination | 11.25 | 9.79 | 9 | 259227 | 5671 | 46421155 |
Conjunctival cyst | 11.23 | 9.79 | 6 | 259230 | 59 | 46426767 |
Plasma cell myeloma | 11.21 | 9.79 | 325 | 258911 | 44153 | 46382673 |
Product residue present | 11.19 | 9.79 | 47 | 259189 | 3835 | 46422991 |
Complication associated with device | 11.10 | 9.79 | 46 | 259190 | 15395 | 46411431 |
Epinephrine increased | 11.08 | 9.79 | 4 | 259232 | 13 | 46426813 |
Cystitis haemorrhagic | 11.05 | 9.79 | 3 | 259233 | 3544 | 46423282 |
Psoriatic arthropathy | 11.05 | 9.79 | 139 | 259097 | 36240 | 46390586 |
Dyskinesia | 10.99 | 9.79 | 105 | 259131 | 28820 | 46398006 |
Unevaluable event | 10.99 | 9.79 | 335 | 258901 | 45840 | 46380986 |
Hepatic cyst | 10.98 | 9.79 | 54 | 259182 | 4712 | 46422114 |
HELLP syndrome | 10.98 | 9.79 | 19 | 259217 | 907 | 46425919 |
Shock | 10.82 | 9.79 | 176 | 259060 | 21669 | 46405157 |
Foetal death | 10.81 | 9.79 | 20 | 259216 | 8723 | 46418103 |
Pancytopenia | 10.81 | 9.79 | 375 | 258861 | 84683 | 46342143 |
Cardiac operation | 10.80 | 9.79 | 36 | 259200 | 2630 | 46424196 |
Crohn's disease | 10.79 | 9.79 | 13 | 259223 | 6758 | 46420068 |
Hypertransaminasaemia | 10.77 | 9.79 | 3 | 259233 | 3485 | 46423341 |
Rabbit syndrome | 10.74 | 9.79 | 11 | 259225 | 312 | 46426514 |
Blood electrolytes decreased | 10.74 | 9.79 | 20 | 259216 | 1011 | 46425815 |
Microcephaly | 10.74 | 9.79 | 16 | 259220 | 672 | 46426154 |
Granuloma skin | 10.69 | 9.79 | 3 | 259233 | 3467 | 46423359 |
Somnolence | 10.63 | 9.79 | 737 | 258499 | 155784 | 46271042 |
Hyperaesthesia | 10.60 | 9.79 | 17 | 259219 | 7839 | 46418987 |
Blood pressure immeasurable | 10.60 | 9.79 | 22 | 259214 | 1205 | 46425621 |
Sensitisation | 10.58 | 9.79 | 16 | 259220 | 681 | 46426145 |
Cardiac discomfort | 10.58 | 9.79 | 17 | 259219 | 763 | 46426063 |
Muscle injury | 10.57 | 9.79 | 7 | 259229 | 4859 | 46421967 |
Cerebral artery occlusion | 10.57 | 9.79 | 19 | 259217 | 935 | 46425891 |
Central nervous system injury | 10.56 | 9.79 | 8 | 259228 | 150 | 46426676 |
Post-anoxic myoclonus | 10.56 | 9.79 | 5 | 259231 | 37 | 46426789 |
Cardiac valve disease | 10.54 | 9.79 | 47 | 259189 | 3937 | 46422889 |
Intra-aortic balloon placement | 10.53 | 9.79 | 3 | 259233 | 3 | 46426823 |
Vascular stent thrombosis | 10.49 | 9.79 | 18 | 259218 | 853 | 46425973 |
Eczema eyelids | 10.46 | 9.79 | 7 | 259229 | 107 | 46426719 |
Heart injury | 10.45 | 9.79 | 22 | 259214 | 1217 | 46425609 |
Lacrimal gland enlargement | 10.45 | 9.79 | 4 | 259232 | 16 | 46426810 |
Galactorrhoea | 10.44 | 9.79 | 4 | 259232 | 3793 | 46423033 |
Subclavian vein thrombosis | 10.39 | 9.79 | 28 | 259208 | 1818 | 46425008 |
Ischaemic cerebral infarction | 10.38 | 9.79 | 22 | 259214 | 1223 | 46425603 |
Splenic injury | 10.37 | 9.79 | 9 | 259227 | 206 | 46426620 |
Skin tightness | 10.36 | 9.79 | 46 | 259190 | 3847 | 46422979 |
Coarctation of the aorta | 10.35 | 9.79 | 14 | 259222 | 537 | 46426289 |
Ear infection | 10.32 | 9.79 | 80 | 259156 | 22933 | 46403893 |
Microtia | 10.28 | 9.79 | 11 | 259225 | 329 | 46426497 |
Thrombotic microangiopathy | 10.27 | 9.79 | 19 | 259217 | 8287 | 46418539 |
Aggression | 10.23 | 9.79 | 79 | 259157 | 22665 | 46404161 |
Aspergillus infection | 10.19 | 9.79 | 14 | 259222 | 6876 | 46419950 |
Therapeutic drug monitoring analysis incorrectly performed | 10.17 | 9.79 | 8 | 259228 | 159 | 46426667 |
Injection site bruising | 10.15 | 9.79 | 138 | 259098 | 35498 | 46391328 |
Haemorrhagic transformation stroke | 10.14 | 9.79 | 21 | 259215 | 1149 | 46425677 |
Urate nephropathy | 10.13 | 9.79 | 7 | 259229 | 113 | 46426713 |
Mucosal haemorrhage | 10.07 | 9.79 | 17 | 259219 | 795 | 46426031 |
Cerebral infarction | 10.03 | 9.79 | 184 | 259052 | 23182 | 46403644 |
Hyponatraemia | 10.02 | 9.79 | 672 | 258564 | 100660 | 46326166 |
Hypomania | 9.96 | 9.79 | 6 | 259230 | 4382 | 46422444 |
Cystic fibrosis | 9.95 | 9.79 | 4 | 259232 | 3684 | 46423142 |
Chest wall haematoma | 9.92 | 9.79 | 7 | 259229 | 117 | 46426709 |
Metabolic syndrome | 9.92 | 9.79 | 22 | 259214 | 1262 | 46425564 |
Discomfort | 9.88 | 9.79 | 191 | 259045 | 46479 | 46380347 |
Therapy partial responder | 9.81 | 9.79 | 7 | 259229 | 4675 | 46422151 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myocardial infarction | 1122.33 | 10.68 | 2772 | 227667 | 122853 | 29599186 |
Cardiac failure congestive | 603.35 | 10.68 | 1716 | 228723 | 82691 | 29639348 |
Coronary artery disease | 596.71 | 10.68 | 1235 | 229204 | 48477 | 29673562 |
Bradycardia | 506.41 | 10.68 | 1371 | 229068 | 64155 | 29657884 |
Atrial fibrillation | 487.15 | 10.68 | 1880 | 228559 | 106244 | 29615795 |
Acute myocardial infarction | 320.83 | 10.68 | 1016 | 229423 | 51923 | 29670116 |
Coronary artery bypass | 312.58 | 10.68 | 283 | 230156 | 4879 | 29717160 |
Drug abuse | 293.36 | 10.68 | 132 | 230307 | 81940 | 29640099 |
Dizziness | 250.84 | 10.68 | 2443 | 227996 | 192466 | 29529573 |
Hypotension | 234.60 | 10.68 | 2465 | 227974 | 198100 | 29523939 |
Syncope | 233.80 | 10.68 | 1278 | 229161 | 83625 | 29638414 |
Off label use | 195.76 | 10.68 | 1122 | 229317 | 248168 | 29473871 |
Product prescribing error | 192.69 | 10.68 | 409 | 230030 | 16324 | 29705715 |
Coronary arterial stent insertion | 175.65 | 10.68 | 188 | 230251 | 4006 | 29718033 |
Febrile neutropenia | 154.87 | 10.68 | 372 | 230067 | 106321 | 29615718 |
Neutropenia | 152.58 | 10.68 | 494 | 229945 | 128046 | 29593993 |
Pyrexia | 152.11 | 10.68 | 1491 | 228948 | 292998 | 29429041 |
Cerebrovascular accident | 141.17 | 10.68 | 1112 | 229327 | 82365 | 29639674 |
Dyspnoea | 139.03 | 10.68 | 3448 | 226991 | 329847 | 29392192 |
Drug ineffective | 136.46 | 10.68 | 1824 | 228615 | 338563 | 29383476 |
Angina unstable | 132.70 | 10.68 | 293 | 230146 | 12017 | 29710022 |
Hepatic function abnormal | 131.26 | 10.68 | 80 | 230359 | 41865 | 29680174 |
Drug reaction with eosinophilia and systemic symptoms | 127.62 | 10.68 | 31 | 230408 | 28457 | 29693582 |
Angina pectoris | 105.72 | 10.68 | 479 | 229960 | 29039 | 29693000 |
Product use in unapproved indication | 102.14 | 10.68 | 263 | 230176 | 73430 | 29648609 |
Cardiac disorder | 97.50 | 10.68 | 582 | 229857 | 39311 | 29682728 |
Atrial flutter | 89.08 | 10.68 | 277 | 230162 | 14004 | 29708035 |
Chest pain | 85.15 | 10.68 | 1324 | 229115 | 116303 | 29605736 |
Ventricular tachycardia | 83.79 | 10.68 | 385 | 230054 | 23477 | 29698562 |
Asthma | 83.44 | 10.68 | 93 | 230346 | 36081 | 29685958 |
Interstitial lung disease | 83.28 | 10.68 | 215 | 230224 | 59982 | 29662057 |
Vascular graft | 82.69 | 10.68 | 77 | 230362 | 1378 | 29720661 |
Treatment failure | 80.16 | 10.68 | 89 | 230350 | 34590 | 29687449 |
Asthenia | 76.36 | 10.68 | 2235 | 228204 | 219055 | 29502984 |
Fall | 74.40 | 10.68 | 1878 | 228561 | 179994 | 29542045 |
Rheumatoid arthritis | 73.88 | 10.68 | 127 | 230312 | 41070 | 29680969 |
Hypertensive emergency | 73.32 | 10.68 | 57 | 230382 | 787 | 29721252 |
Haematochezia | 68.08 | 10.68 | 474 | 229965 | 33748 | 29688291 |
Hepatocellular injury | 67.39 | 10.68 | 58 | 230381 | 25413 | 29696626 |
Neutrophil count decreased | 63.94 | 10.68 | 145 | 230294 | 42309 | 29679730 |
Coronary artery occlusion | 62.86 | 10.68 | 209 | 230230 | 10948 | 29711091 |
International normalised ratio increased | 61.88 | 10.68 | 600 | 229839 | 47139 | 29674900 |
Acute coronary syndrome | 60.89 | 10.68 | 236 | 230203 | 13337 | 29708702 |
Mucosal inflammation | 58.42 | 10.68 | 90 | 230349 | 30404 | 29691635 |
Eosinophilia | 57.97 | 10.68 | 51 | 230388 | 22109 | 29699930 |
Septic shock | 57.13 | 10.68 | 273 | 230166 | 63334 | 29658705 |
Completed suicide | 57.12 | 10.68 | 1079 | 229360 | 98413 | 29623626 |
Gastrointestinal haemorrhage | 56.84 | 10.68 | 930 | 229509 | 82516 | 29639523 |
General physical health deterioration | 56.72 | 10.68 | 1082 | 229357 | 98862 | 29623177 |
Bone marrow failure | 56.02 | 10.68 | 89 | 230350 | 29696 | 29692343 |
Immune reconstitution inflammatory syndrome | 54.58 | 10.68 | 4 | 230435 | 9097 | 29712942 |
Thrombocytopenia | 53.66 | 10.68 | 737 | 229702 | 136307 | 29585732 |
Drug resistance | 53.07 | 10.68 | 46 | 230393 | 20087 | 29701952 |
Arrhythmia | 52.80 | 10.68 | 436 | 230003 | 32733 | 29689306 |
Cytomegalovirus infection | 52.29 | 10.68 | 63 | 230376 | 23611 | 29698428 |
Drug dependence | 52.19 | 10.68 | 52 | 230387 | 21243 | 29700796 |
Lower respiratory tract infection | 51.99 | 10.68 | 78 | 230361 | 26636 | 29695403 |
Myocardial ischaemia | 51.88 | 10.68 | 267 | 230172 | 17050 | 29704989 |
Infective pulmonary exacerbation of cystic fibrosis | 50.75 | 10.68 | 4 | 230435 | 8568 | 29713471 |
Suicidal ideation | 50.69 | 10.68 | 128 | 230311 | 35986 | 29686053 |
Fatigue | 50.54 | 10.68 | 2980 | 227459 | 317693 | 29404346 |
Seizure | 50.39 | 10.68 | 499 | 229940 | 97976 | 29624063 |
Toxic skin eruption | 49.30 | 10.68 | 12 | 230427 | 11003 | 29711036 |
Pneumocystis jirovecii pneumonia | 49.04 | 10.68 | 36 | 230403 | 17084 | 29704955 |
Rash maculo-papular | 48.71 | 10.68 | 75 | 230364 | 25343 | 29696696 |
Sinus bradycardia | 48.17 | 10.68 | 198 | 230241 | 11497 | 29710542 |
Infusion related reaction | 47.96 | 10.68 | 156 | 230283 | 40408 | 29681631 |
Sopor | 47.23 | 10.68 | 13 | 230426 | 10978 | 29711061 |
Coronary artery stenosis | 45.94 | 10.68 | 164 | 230275 | 8906 | 29713133 |
Pathogen resistance | 44.44 | 10.68 | 6 | 230433 | 8404 | 29713635 |
Bronchopulmonary aspergillosis | 43.46 | 10.68 | 20 | 230419 | 12264 | 29709775 |
Palpitations | 42.54 | 10.68 | 420 | 230019 | 33153 | 29688886 |
Agitation | 42.43 | 10.68 | 243 | 230196 | 53830 | 29668209 |
Heart rate decreased | 41.87 | 10.68 | 291 | 230148 | 20703 | 29701336 |
Toxic epidermal necrolysis | 41.50 | 10.68 | 46 | 230393 | 17894 | 29704145 |
Therapeutic product effect incomplete | 41.48 | 10.68 | 128 | 230311 | 33706 | 29688333 |
Liver disorder | 41.20 | 10.68 | 106 | 230333 | 29616 | 29692423 |
Disseminated intravascular coagulation | 40.99 | 10.68 | 67 | 230372 | 22104 | 29699935 |
Aggression | 40.87 | 10.68 | 146 | 230293 | 36761 | 29685278 |
Abnormal behaviour | 38.99 | 10.68 | 87 | 230352 | 25536 | 29696503 |
Nodal arrhythmia | 38.71 | 10.68 | 40 | 230399 | 817 | 29721222 |
Lymphopenia | 38.59 | 10.68 | 27 | 230412 | 13136 | 29708903 |
Cholestasis | 38.56 | 10.68 | 84 | 230355 | 24866 | 29697173 |
Wound | 37.69 | 10.68 | 192 | 230247 | 12210 | 29709829 |
Transient ischaemic attack | 36.81 | 10.68 | 325 | 230114 | 24875 | 29697164 |
Haemorrhage intracranial | 36.51 | 10.68 | 219 | 230220 | 14813 | 29707226 |
Injury | 36.39 | 10.68 | 289 | 230150 | 21442 | 29700597 |
Atrioventricular block | 36.31 | 10.68 | 131 | 230308 | 7151 | 29714888 |
Agranulocytosis | 35.48 | 10.68 | 72 | 230367 | 21870 | 29700169 |
Hyperthermia | 34.87 | 10.68 | 17 | 230422 | 10082 | 29711957 |
Headache | 33.79 | 10.68 | 1107 | 229332 | 181199 | 29540840 |
Irritability | 33.67 | 10.68 | 80 | 230359 | 22970 | 29699069 |
Haematotoxicity | 33.58 | 10.68 | 4 | 230435 | 6166 | 29715873 |
Sinus node dysfunction | 33.28 | 10.68 | 84 | 230355 | 3759 | 29718280 |
Dehydration | 33.23 | 10.68 | 1212 | 229227 | 122327 | 29599712 |
Renal injury | 33.18 | 10.68 | 178 | 230261 | 11551 | 29710488 |
Acute generalised exanthematous pustulosis | 33.07 | 10.68 | 4 | 230435 | 6094 | 29715945 |
Substance abuse | 32.84 | 10.68 | 7 | 230432 | 7033 | 29715006 |
Drug eruption | 32.36 | 10.68 | 53 | 230386 | 17473 | 29704566 |
Cardiac arrest | 32.23 | 10.68 | 939 | 229500 | 91911 | 29630128 |
Hypertension | 31.29 | 10.68 | 1185 | 229254 | 120169 | 29601870 |
Urticaria | 31.24 | 10.68 | 269 | 230170 | 54337 | 29667702 |
Blood loss anaemia | 30.52 | 10.68 | 128 | 230311 | 7499 | 29714540 |
Anhedonia | 30.09 | 10.68 | 136 | 230303 | 8233 | 29713806 |
Overdose | 30.01 | 10.68 | 462 | 229977 | 83875 | 29638164 |
Pancytopenia | 29.90 | 10.68 | 467 | 229972 | 84585 | 29637454 |
Progressive multifocal leukoencephalopathy | 29.88 | 10.68 | 16 | 230423 | 8997 | 29713042 |
Oedema peripheral | 29.86 | 10.68 | 1044 | 229395 | 104788 | 29617251 |
Chronotropic incompetence | 29.75 | 10.68 | 9 | 230430 | 7 | 29722032 |
Mitral valve disease | 29.36 | 10.68 | 40 | 230399 | 1104 | 29720935 |
Acute graft versus host disease | 29.12 | 10.68 | 5 | 230434 | 5859 | 29716180 |
Device interaction | 28.97 | 10.68 | 25 | 230414 | 403 | 29721636 |
Hyperbilirubinaemia | 28.77 | 10.68 | 54 | 230385 | 16888 | 29705151 |
Synovitis | 28.77 | 10.68 | 20 | 230419 | 9763 | 29712276 |
Aspergillus infection | 28.58 | 10.68 | 22 | 230417 | 10192 | 29711847 |
Fear | 28.42 | 10.68 | 161 | 230278 | 10664 | 29711375 |
Altered state of consciousness | 28.41 | 10.68 | 70 | 230369 | 19849 | 29702190 |
Presyncope | 28.25 | 10.68 | 216 | 230223 | 15840 | 29706199 |
Myxoedema coma | 27.80 | 10.68 | 21 | 230418 | 277 | 29721762 |
Unevaluable event | 27.80 | 10.68 | 370 | 230069 | 31415 | 29690624 |
Peritonitis | 27.55 | 10.68 | 79 | 230360 | 21296 | 29700743 |
Haemophagocytic lymphohistiocytosis | 27.51 | 10.68 | 21 | 230418 | 9770 | 29712269 |
Sinus arrest | 27.34 | 10.68 | 45 | 230394 | 1475 | 29720564 |
BRASH syndrome | 27.16 | 10.68 | 11 | 230428 | 35 | 29722004 |
Supraventricular tachycardia | 27.12 | 10.68 | 153 | 230286 | 10119 | 29711920 |
Malignant neoplasm progression | 27.09 | 10.68 | 392 | 230047 | 71895 | 29650144 |
Shone complex | 26.96 | 10.68 | 13 | 230426 | 69 | 29721970 |
Intentional product use issue | 26.87 | 10.68 | 167 | 230272 | 36273 | 29685766 |
Mitral valve incompetence | 26.72 | 10.68 | 184 | 230255 | 13050 | 29708989 |
Hepatocellular carcinoma | 26.51 | 10.68 | 21 | 230418 | 9589 | 29712450 |
Epilepsy | 26.39 | 10.68 | 74 | 230365 | 20095 | 29701944 |
Alanine aminotransferase increased | 26.39 | 10.68 | 407 | 230032 | 73869 | 29648170 |
Anaphylactic shock | 26.13 | 10.68 | 42 | 230397 | 13951 | 29708088 |
Graft versus host disease | 25.78 | 10.68 | 24 | 230415 | 10126 | 29711913 |
Anaphylactic reaction | 25.76 | 10.68 | 119 | 230320 | 27863 | 29694176 |
Atrioventricular block complete | 25.60 | 10.68 | 131 | 230308 | 8346 | 29713693 |
Neuroleptic malignant syndrome | 25.06 | 10.68 | 55 | 230384 | 16240 | 29705799 |
Malaise | 25.04 | 10.68 | 1040 | 229399 | 165922 | 29556117 |
Haematoma | 24.90 | 10.68 | 288 | 230151 | 23665 | 29698374 |
Respiratory distress | 24.88 | 10.68 | 150 | 230289 | 32822 | 29689217 |
Product use issue | 24.43 | 10.68 | 231 | 230208 | 45785 | 29676254 |
Jaundice | 24.41 | 10.68 | 148 | 230291 | 32338 | 29689701 |
Drug withdrawal syndrome | 24.24 | 10.68 | 75 | 230364 | 19734 | 29702305 |
Rash | 24.19 | 10.68 | 1218 | 229221 | 190671 | 29531368 |
C-reactive protein increased | 24.05 | 10.68 | 216 | 230223 | 43257 | 29678782 |
Aortic stenosis | 23.85 | 10.68 | 77 | 230362 | 3971 | 29718068 |
Coma | 23.70 | 10.68 | 198 | 230241 | 40251 | 29681788 |
Osteonecrosis | 23.57 | 10.68 | 56 | 230383 | 16079 | 29705960 |
Ventricular fibrillation | 23.55 | 10.68 | 198 | 230241 | 14940 | 29707099 |
Pericardial haemorrhage | 23.44 | 10.68 | 62 | 230377 | 2856 | 29719183 |
Exposure during pregnancy | 23.40 | 10.68 | 22 | 230417 | 9239 | 29712800 |
Cardiac operation | 23.39 | 10.68 | 57 | 230382 | 2495 | 29719544 |
C-reactive protein abnormal | 23.32 | 10.68 | 7 | 230432 | 5586 | 29716453 |
Diffuse large B-cell lymphoma | 23.09 | 10.68 | 16 | 230423 | 7825 | 29714214 |
Aspartate aminotransferase increased | 23.04 | 10.68 | 346 | 230093 | 63076 | 29658963 |
Respiratory depression | 22.95 | 10.68 | 33 | 230406 | 11470 | 29710569 |
Nodular rash | 22.87 | 10.68 | 11 | 230428 | 58 | 29721981 |
Erythema multiforme | 22.60 | 10.68 | 17 | 230422 | 7968 | 29714071 |
Pneumonia aspiration | 22.56 | 10.68 | 184 | 230255 | 37596 | 29684443 |
Stomatitis | 22.51 | 10.68 | 181 | 230258 | 37098 | 29684941 |
Drug hypersensitivity | 22.49 | 10.68 | 381 | 230058 | 68138 | 29653901 |
Cardiogenic shock | 22.37 | 10.68 | 213 | 230226 | 16648 | 29705391 |
Suicide attempt | 22.24 | 10.68 | 178 | 230261 | 36519 | 29685520 |
Troponin increased | 22.12 | 10.68 | 130 | 230309 | 8727 | 29713312 |
Epstein-Barr virus infection | 22.09 | 10.68 | 12 | 230427 | 6694 | 29715345 |
Carcinoma in situ of skin | 22.08 | 10.68 | 12 | 230427 | 85 | 29721954 |
Peripheral vascular disorder | 22.00 | 10.68 | 89 | 230350 | 5130 | 29716909 |
Hypertriglyceridaemia | 21.96 | 10.68 | 18 | 230421 | 8080 | 29713959 |
Hepatitis | 21.83 | 10.68 | 93 | 230346 | 22263 | 29699776 |
Aorta hypoplasia | 21.62 | 10.68 | 12 | 230427 | 89 | 29721950 |
Chronic graft versus host disease | 21.62 | 10.68 | 3 | 230436 | 4116 | 29717923 |
Venoocclusive liver disease | 21.55 | 10.68 | 12 | 230427 | 6601 | 29715438 |
Arteriosclerosis | 21.50 | 10.68 | 150 | 230289 | 10683 | 29711356 |
Psychomotor hyperactivity | 21.42 | 10.68 | 19 | 230420 | 8205 | 29713834 |
Hyponatraemia | 21.31 | 10.68 | 376 | 230063 | 66826 | 29655213 |
Hepatitis B | 21.30 | 10.68 | 10 | 230429 | 6062 | 29715977 |
Neuropathy vitamin B12 deficiency | 21.13 | 10.68 | 8 | 230431 | 20 | 29722019 |
Blood pressure inadequately controlled | 21.04 | 10.68 | 55 | 230384 | 2515 | 29719524 |
Erythema | 21.00 | 10.68 | 445 | 229994 | 77006 | 29645033 |
Hypoalbuminaemia | 20.99 | 10.68 | 33 | 230406 | 11059 | 29710980 |
Blood glucose increased | 20.99 | 10.68 | 621 | 229818 | 60909 | 29661130 |
Ascites | 20.97 | 10.68 | 176 | 230263 | 35745 | 29686294 |
White blood cell count decreased | 20.86 | 10.68 | 489 | 229950 | 83458 | 29638581 |
Colitis | 20.82 | 10.68 | 145 | 230294 | 30675 | 29691364 |
Ejection fraction decreased | 20.78 | 10.68 | 193 | 230246 | 14982 | 29707057 |
Internal haemorrhage | 20.75 | 10.68 | 78 | 230361 | 4344 | 29717695 |
Pacemaker generated rhythm | 20.67 | 10.68 | 9 | 230430 | 36 | 29722003 |
Blood pressure increased | 20.63 | 10.68 | 711 | 229728 | 71217 | 29650822 |
Hepatojugular reflux | 20.59 | 10.68 | 19 | 230420 | 336 | 29721703 |
Product monitoring error | 20.55 | 10.68 | 43 | 230396 | 1698 | 29720341 |
Low density lipoprotein abnormal | 20.49 | 10.68 | 17 | 230422 | 259 | 29721780 |
Hypertensive crisis | 20.45 | 10.68 | 122 | 230317 | 8235 | 29713804 |
Stevens-Johnson syndrome | 20.41 | 10.68 | 68 | 230371 | 17488 | 29704551 |
Pancreatitis acute | 20.40 | 10.68 | 115 | 230324 | 25580 | 29696459 |
Therapeutic drug monitoring analysis not performed | 20.30 | 10.68 | 20 | 230419 | 385 | 29721654 |
Acute lung injury | 20.22 | 10.68 | 33 | 230406 | 1074 | 29720965 |
Rhabdomyolysis | 20.17 | 10.68 | 636 | 229803 | 62944 | 29659095 |
Nocturia | 20.12 | 10.68 | 121 | 230318 | 8191 | 29713848 |
Alcohol abuse | 20.08 | 10.68 | 8 | 230431 | 5345 | 29716694 |
Extrapyramidal disorder | 20.06 | 10.68 | 32 | 230407 | 10661 | 29711378 |
Coagulopathy | 19.99 | 10.68 | 224 | 230215 | 18263 | 29703776 |
Status epilepticus | 19.96 | 10.68 | 34 | 230405 | 11038 | 29711001 |
Heart rate irregular | 19.96 | 10.68 | 162 | 230277 | 12097 | 29709942 |
Upper motor neurone lesion | 19.61 | 10.68 | 12 | 230427 | 109 | 29721930 |
Contusion | 19.58 | 10.68 | 344 | 230095 | 30936 | 29691103 |
Oesophageal obstruction | 19.53 | 10.68 | 20 | 230419 | 404 | 29721635 |
Mental status changes | 19.51 | 10.68 | 397 | 230042 | 36682 | 29685357 |
Cardiac failure | 19.48 | 10.68 | 806 | 229633 | 82612 | 29639427 |
Dyskinesia | 19.42 | 10.68 | 94 | 230345 | 21740 | 29700299 |
Hepatic encephalopathy | 19.37 | 10.68 | 51 | 230388 | 14141 | 29707898 |
Immune thrombocytopenia | 19.22 | 10.68 | 18 | 230421 | 7573 | 29714466 |
Hepatitis C | 19.15 | 10.68 | 46 | 230393 | 13159 | 29708880 |
Infection | 19.06 | 10.68 | 456 | 229983 | 77618 | 29644421 |
Supravalvular aortic stenosis | 18.94 | 10.68 | 9 | 230430 | 46 | 29721993 |
Non-cardiac chest pain | 18.93 | 10.68 | 72 | 230367 | 4032 | 29718007 |
Leukopenia | 18.84 | 10.68 | 311 | 230128 | 55848 | 29666191 |
Nephrogenic systemic fibrosis | 18.79 | 10.68 | 75 | 230364 | 4296 | 29717743 |
Large for dates baby | 18.77 | 10.68 | 28 | 230411 | 842 | 29721197 |
Toxicity to various agents | 18.75 | 10.68 | 1144 | 229295 | 176039 | 29546000 |
Pulmonary tuberculosis | 18.65 | 10.68 | 7 | 230432 | 4850 | 29717189 |
Intracardiac thrombus | 18.64 | 10.68 | 51 | 230388 | 2397 | 29719642 |
Sedation | 18.64 | 10.68 | 64 | 230375 | 16309 | 29705730 |
Leukoencephalopathy | 18.63 | 10.68 | 4 | 230435 | 3998 | 29718041 |
Arteriosclerosis coronary artery | 18.37 | 10.68 | 148 | 230291 | 11028 | 29711011 |
Tuberculosis | 18.36 | 10.68 | 21 | 230418 | 8056 | 29713983 |
Multiple organ dysfunction syndrome | 18.33 | 10.68 | 361 | 230078 | 63126 | 29658913 |
Blood pressure abnormal | 18.31 | 10.68 | 104 | 230335 | 6895 | 29715144 |
Fracture | 18.26 | 10.68 | 93 | 230346 | 5913 | 29716126 |
Occult blood positive | 18.20 | 10.68 | 67 | 230372 | 3693 | 29718346 |
Cardiac valve disease | 18.20 | 10.68 | 57 | 230382 | 2892 | 29719147 |
Orthostatic hypotension | 18.10 | 10.68 | 272 | 230167 | 23707 | 29698332 |
Heart rate increased | 17.93 | 10.68 | 407 | 230032 | 38314 | 29683725 |
Pruritus genital | 17.89 | 10.68 | 20 | 230419 | 448 | 29721591 |
Macrophages increased | 17.89 | 10.68 | 13 | 230426 | 161 | 29721878 |
Dysgeusia | 17.83 | 10.68 | 279 | 230160 | 24522 | 29697517 |
Cornea verticillata | 17.82 | 10.68 | 8 | 230431 | 35 | 29722004 |
Face oedema | 17.64 | 10.68 | 38 | 230401 | 11296 | 29710743 |
Sepsis | 17.52 | 10.68 | 934 | 229505 | 145461 | 29576578 |
Stent placement | 17.52 | 10.68 | 76 | 230363 | 4520 | 29717519 |
Basal ganglia haemorrhage | 17.52 | 10.68 | 27 | 230412 | 836 | 29721203 |
Drug abuser | 17.48 | 10.68 | 6 | 230433 | 4395 | 29717644 |
Bundle branch block right | 17.36 | 10.68 | 103 | 230336 | 6939 | 29715100 |
Ventricular extrasystoles | 17.28 | 10.68 | 149 | 230290 | 11325 | 29710714 |
Full blood count decreased | 17.25 | 10.68 | 191 | 230248 | 15526 | 29706513 |
Lower gastrointestinal haemorrhage | 17.22 | 10.68 | 112 | 230327 | 7792 | 29714247 |
Gamma-glutamyltransferase increased | 17.04 | 10.68 | 144 | 230295 | 29206 | 29692833 |
Psoriatic arthropathy | 17.01 | 10.68 | 63 | 230376 | 15698 | 29706341 |
Diabetic foetopathy | 16.94 | 10.68 | 14 | 230425 | 212 | 29721827 |
Mitral valve hypoplasia | 16.66 | 10.68 | 8 | 230431 | 42 | 29721997 |
Nodal rhythm | 16.63 | 10.68 | 35 | 230404 | 1388 | 29720651 |
Sinusitis | 16.60 | 10.68 | 170 | 230269 | 33175 | 29688864 |
Gout | 16.59 | 10.68 | 205 | 230234 | 17110 | 29704929 |
Orthostatic intolerance | 16.58 | 10.68 | 24 | 230415 | 702 | 29721337 |
Atrioventricular block first degree | 16.55 | 10.68 | 87 | 230352 | 5601 | 29716438 |
Blood glucose decreased | 16.38 | 10.68 | 163 | 230276 | 12890 | 29709149 |
Foetal exposure during pregnancy | 16.36 | 10.68 | 193 | 230246 | 36678 | 29685361 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 16.32 | 10.68 | 22 | 230417 | 601 | 29721438 |
Vomiting | 16.25 | 10.68 | 1463 | 228976 | 218355 | 29503684 |
Ventricular hypokinesia | 16.22 | 10.68 | 70 | 230369 | 4153 | 29717886 |
Blood creatinine increased | 16.21 | 10.68 | 859 | 229580 | 90516 | 29631523 |
Atrial thrombosis | 16.17 | 10.68 | 41 | 230398 | 1840 | 29720199 |
Mouth ulceration | 16.16 | 10.68 | 36 | 230403 | 10573 | 29711466 |
Emotional distress | 16.14 | 10.68 | 189 | 230250 | 15576 | 29706463 |
Neonatal respiratory failure | 16.03 | 10.68 | 16 | 230423 | 313 | 29721726 |
Penis injury | 15.86 | 10.68 | 14 | 230425 | 233 | 29721806 |
Chronic kidney disease | 15.78 | 10.68 | 392 | 230047 | 37446 | 29684593 |
Cytomegalovirus chorioretinitis | 15.77 | 10.68 | 3 | 230436 | 3265 | 29718774 |
Withdrawal syndrome | 15.68 | 10.68 | 40 | 230399 | 11210 | 29710829 |
Dyspnoea exertional | 15.66 | 10.68 | 370 | 230069 | 35060 | 29686979 |
Pulmonary renal syndrome | 15.66 | 10.68 | 12 | 230427 | 162 | 29721877 |
Systemic infection | 15.53 | 10.68 | 23 | 230416 | 687 | 29721352 |
Nephropathy toxic | 15.48 | 10.68 | 37 | 230402 | 10602 | 29711437 |
Eczema | 15.39 | 10.68 | 52 | 230387 | 13317 | 29708722 |
Eosinophil count increased | 15.35 | 10.68 | 21 | 230418 | 7452 | 29714587 |
Cerebral haemorrhage | 15.33 | 10.68 | 346 | 230093 | 32541 | 29689498 |
Fluid retention | 15.32 | 10.68 | 274 | 230165 | 24724 | 29697315 |
Coronary angioplasty | 15.31 | 10.68 | 17 | 230422 | 378 | 29721661 |
Abdominal pain lower | 15.28 | 10.68 | 118 | 230321 | 8680 | 29713359 |
Blood urine present | 15.14 | 10.68 | 129 | 230310 | 9771 | 29712268 |
Vascular stent thrombosis | 15.12 | 10.68 | 46 | 230393 | 2297 | 29719742 |
Uveitis | 15.07 | 10.68 | 12 | 230427 | 5465 | 29716574 |
Congenital heart valve disorder | 15.04 | 10.68 | 8 | 230431 | 54 | 29721985 |
Haemodilution | 15.01 | 10.68 | 7 | 230432 | 34 | 29722005 |
Acute graft versus host disease in skin | 15.00 | 10.68 | 8 | 230431 | 4508 | 29717531 |
Product residue present | 14.93 | 10.68 | 50 | 230389 | 2628 | 29719411 |
Blood pressure orthostatic | 14.91 | 10.68 | 8 | 230431 | 55 | 29721984 |
Lymphoma | 14.88 | 10.68 | 35 | 230404 | 10086 | 29711953 |
Device related infection | 14.70 | 10.68 | 74 | 230365 | 16941 | 29705098 |
Peritonitis bacterial | 14.70 | 10.68 | 42 | 230397 | 11336 | 29710703 |
Intentional self-injury | 14.67 | 10.68 | 54 | 230385 | 13478 | 29708561 |
Renal failure | 14.63 | 10.68 | 1167 | 229272 | 127799 | 29594240 |
Myelosuppression | 14.61 | 10.68 | 21 | 230418 | 7301 | 29714738 |
Biopsy lymph gland | 14.57 | 10.68 | 8 | 230431 | 58 | 29721981 |
Obstructive airways disorder | 14.41 | 10.68 | 30 | 230409 | 9029 | 29713010 |
Ageusia | 14.41 | 10.68 | 118 | 230321 | 8835 | 29713204 |
Cardiovascular insufficiency | 14.34 | 10.68 | 34 | 230405 | 1462 | 29720577 |
Precancerous skin lesion | 14.31 | 10.68 | 20 | 230419 | 566 | 29721473 |
Electrocardiogram QRS complex prolonged | 14.27 | 10.68 | 68 | 230371 | 4209 | 29717830 |
Platelet count decreased | 14.25 | 10.68 | 669 | 229770 | 105460 | 29616579 |
Systolic anterior motion of mitral valve | 14.25 | 10.68 | 7 | 230432 | 39 | 29722000 |
Post procedural haemorrhage | 14.24 | 10.68 | 107 | 230332 | 7803 | 29714236 |
Lung disorder | 14.24 | 10.68 | 164 | 230275 | 31305 | 29690734 |
Tumour lysis syndrome | 14.24 | 10.68 | 51 | 230388 | 12834 | 29709205 |
Hyperkalaemia | 14.11 | 10.68 | 632 | 229807 | 65378 | 29656661 |
Neutropenic sepsis | 14.10 | 10.68 | 43 | 230396 | 11366 | 29710673 |
Heart valve incompetence | 13.83 | 10.68 | 28 | 230411 | 1080 | 29720959 |
Exercise tolerance decreased | 13.74 | 10.68 | 62 | 230377 | 3750 | 29718289 |
Neuropathy peripheral | 13.72 | 10.68 | 425 | 230014 | 70050 | 29651989 |
Pallor | 13.72 | 10.68 | 233 | 230206 | 20816 | 29701223 |
Haemoglobin decreased | 13.69 | 10.68 | 1037 | 229402 | 113061 | 29608978 |
Penile haemorrhage | 13.61 | 10.68 | 20 | 230419 | 593 | 29721446 |
Tenosynovitis | 13.60 | 10.68 | 5 | 230434 | 3510 | 29718529 |
Heart rate abnormal | 13.58 | 10.68 | 34 | 230405 | 1514 | 29720525 |
Multiple-drug resistance | 13.57 | 10.68 | 3 | 230436 | 2938 | 29719101 |
Priapism | 13.55 | 10.68 | 10 | 230429 | 4733 | 29717306 |
Increased tendency to bruise | 13.48 | 10.68 | 59 | 230380 | 3522 | 29718517 |
Essential hypertension | 13.48 | 10.68 | 46 | 230393 | 2442 | 29719597 |
Intracranial pressure increased | 13.45 | 10.68 | 5 | 230434 | 3485 | 29718554 |
Acoustic stimulation tests abnormal | 13.32 | 10.68 | 8 | 230431 | 70 | 29721969 |
Thrombotic microangiopathy | 13.29 | 10.68 | 29 | 230410 | 8581 | 29713458 |
Extrasystoles | 13.25 | 10.68 | 61 | 230378 | 3721 | 29718318 |
Drug intolerance | 13.23 | 10.68 | 257 | 230182 | 45034 | 29677005 |
Nocardiosis | 13.23 | 10.68 | 5 | 230434 | 3450 | 29718589 |
Arteriosclerotic gangrene | 13.23 | 10.68 | 8 | 230431 | 71 | 29721968 |
Somnolence | 13.19 | 10.68 | 609 | 229830 | 96154 | 29625885 |
Cardio-respiratory arrest | 13.09 | 10.68 | 338 | 230101 | 56968 | 29665071 |
Neonatal tachycardia | 13.07 | 10.68 | 5 | 230434 | 13 | 29722026 |
Pulseless electrical activity | 13.07 | 10.68 | 87 | 230352 | 6100 | 29715939 |
Orthopnoea | 12.91 | 10.68 | 69 | 230370 | 4471 | 29717568 |
Parathyroid hormone-related protein abnormal | 12.81 | 10.68 | 5 | 230434 | 14 | 29722025 |
Obsessive-compulsive disorder | 12.81 | 10.68 | 8 | 230431 | 4133 | 29717906 |
Pulmonary valve stenosis congenital | 12.75 | 10.68 | 10 | 230429 | 140 | 29721899 |
Cardiac function test abnormal | 12.73 | 10.68 | 6 | 230433 | 30 | 29722009 |
Cardiac failure chronic | 12.72 | 10.68 | 83 | 230356 | 5780 | 29716259 |
Peritoneal dialysis complication | 12.72 | 10.68 | 8 | 230431 | 4119 | 29717920 |
Carcinoid tumour of the gastrointestinal tract | 12.72 | 10.68 | 7 | 230432 | 51 | 29721988 |
Dermatitis acneiform | 12.71 | 10.68 | 15 | 230424 | 5674 | 29716365 |
Apallic syndrome | 12.68 | 10.68 | 13 | 230426 | 263 | 29721776 |
Pulse pressure decreased | 12.56 | 10.68 | 11 | 230428 | 181 | 29721858 |
Patent ductus arteriosus | 12.54 | 10.68 | 53 | 230386 | 3116 | 29718923 |
Acute lymphocytic leukaemia | 12.53 | 10.68 | 4 | 230435 | 3068 | 29718971 |
Hyperferritinaemia | 12.49 | 10.68 | 15 | 230424 | 364 | 29721675 |
Bradycardia neonatal | 12.46 | 10.68 | 24 | 230415 | 892 | 29721147 |
Asphyxia | 12.45 | 10.68 | 14 | 230425 | 5411 | 29716628 |
Glomerular filtration rate decreased | 12.43 | 10.68 | 138 | 230301 | 11224 | 29710815 |
Lymphomatoid papulosis | 12.37 | 10.68 | 11 | 230428 | 185 | 29721854 |
Euphoric mood | 12.31 | 10.68 | 9 | 230430 | 4281 | 29717758 |
Graft versus host disease in skin | 12.31 | 10.68 | 5 | 230434 | 3302 | 29718737 |
Psychotic disorder | 12.29 | 10.68 | 106 | 230333 | 21409 | 29700630 |
Generalised tonic-clonic seizure | 12.23 | 10.68 | 94 | 230345 | 19457 | 29702582 |
Hyperlipidaemia | 12.20 | 10.68 | 162 | 230277 | 13745 | 29708294 |
Depression | 12.16 | 10.68 | 570 | 229869 | 89867 | 29632172 |
Kidney rupture | 12.14 | 10.68 | 12 | 230427 | 232 | 29721807 |
Tricuspid valve incompetence | 11.97 | 10.68 | 110 | 230329 | 8513 | 29713526 |
Blood bilirubin increased | 11.92 | 10.68 | 204 | 230235 | 36432 | 29685607 |
Chest discomfort | 11.91 | 10.68 | 445 | 229994 | 45035 | 29677004 |
Tooth socket haemorrhage | 11.88 | 10.68 | 5 | 230434 | 18 | 29722021 |
Hyperammonaemia | 11.86 | 10.68 | 15 | 230424 | 5505 | 29716534 |
Circulatory collapse | 11.84 | 10.68 | 220 | 230219 | 19994 | 29702045 |
Dizziness postural | 11.83 | 10.68 | 78 | 230361 | 5452 | 29716587 |
Facial asymmetry | 11.82 | 10.68 | 13 | 230426 | 286 | 29721753 |
Actinic keratosis | 11.81 | 10.68 | 57 | 230382 | 3546 | 29718493 |
Dystonia | 11.78 | 10.68 | 37 | 230402 | 9690 | 29712349 |
No adverse event | 11.74 | 10.68 | 82 | 230357 | 17337 | 29704702 |
Torsade de pointes | 11.70 | 10.68 | 95 | 230344 | 7095 | 29714944 |
Blue toe syndrome | 11.65 | 10.68 | 10 | 230429 | 160 | 29721879 |
Venous pressure jugular abnormal | 11.63 | 10.68 | 3 | 230436 | 0 | 29722039 |
Non-small cell lung cancer stage IIIA | 11.63 | 10.68 | 3 | 230436 | 0 | 29722039 |
Paraganglion neoplasm | 11.63 | 10.68 | 3 | 230436 | 0 | 29722039 |
Haemorrhage | 11.62 | 10.68 | 449 | 229990 | 45630 | 29676409 |
Diverticulum intestinal haemorrhagic | 11.58 | 10.68 | 39 | 230400 | 2056 | 29719983 |
Balance disorder | 11.55 | 10.68 | 365 | 230074 | 36128 | 29685911 |
Diverticulum | 11.52 | 10.68 | 90 | 230349 | 6643 | 29715396 |
Therapeutic product effect decreased | 11.48 | 10.68 | 156 | 230283 | 28920 | 29693119 |
Blood cholinesterase decreased | 11.47 | 10.68 | 9 | 230430 | 126 | 29721913 |
Oral candidiasis | 11.47 | 10.68 | 45 | 230394 | 11026 | 29711013 |
Myelomalacia | 11.46 | 10.68 | 6 | 230433 | 39 | 29722000 |
Affect lability | 11.43 | 10.68 | 6 | 230433 | 3412 | 29718627 |
High density lipoprotein decreased | 11.42 | 10.68 | 52 | 230387 | 3158 | 29718881 |
Thoracic haemorrhage | 11.41 | 10.68 | 11 | 230428 | 206 | 29721833 |
Pleural mass | 11.40 | 10.68 | 7 | 230432 | 64 | 29721975 |
Halo vision | 11.40 | 10.68 | 10 | 230429 | 165 | 29721874 |
Cystitis haemorrhagic | 11.37 | 10.68 | 12 | 230427 | 4775 | 29717264 |
Aortic valve sclerosis | 11.31 | 10.68 | 23 | 230416 | 890 | 29721149 |
Folliculitis | 11.30 | 10.68 | 7 | 230432 | 3633 | 29718406 |
Urinary tract obstruction | 11.29 | 10.68 | 54 | 230385 | 3347 | 29718692 |
Schizophrenia | 11.25 | 10.68 | 34 | 230405 | 9014 | 29713025 |
Venoocclusive disease | 11.25 | 10.68 | 3 | 230436 | 2587 | 29719452 |
Arterial occlusive disease | 11.21 | 10.68 | 61 | 230378 | 3979 | 29718060 |
Blood ethanol increased | 11.18 | 10.68 | 14 | 230425 | 355 | 29721684 |
Atrial septal defect | 11.15 | 10.68 | 89 | 230350 | 6612 | 29715427 |
Iliac artery stenosis | 11.15 | 10.68 | 8 | 230431 | 97 | 29721942 |
Aortic aneurysm | 11.13 | 10.68 | 86 | 230353 | 6327 | 29715712 |
Acute myeloid leukaemia | 11.07 | 10.68 | 87 | 230352 | 17919 | 29704120 |
Blood ketone body increased | 11.03 | 10.68 | 14 | 230425 | 360 | 29721679 |
Disease progression | 11.02 | 10.68 | 502 | 229937 | 79372 | 29642667 |
Cytopenia | 11.02 | 10.68 | 30 | 230409 | 8226 | 29713813 |
Implantable defibrillator insertion | 10.98 | 10.68 | 20 | 230419 | 712 | 29721327 |
Aplasia | 10.91 | 10.68 | 9 | 230430 | 4028 | 29718011 |
Atrial tachycardia | 10.90 | 10.68 | 39 | 230400 | 2120 | 29719919 |
Central nervous system lesion | 10.89 | 10.68 | 13 | 230426 | 4893 | 29717146 |
Epidural haemorrhage | 10.86 | 10.68 | 4 | 230435 | 9 | 29722030 |
Graft versus host disease in gastrointestinal tract | 10.85 | 10.68 | 5 | 230434 | 3064 | 29718975 |
Electrocardiogram ST-T segment abnormal | 10.83 | 10.68 | 11 | 230428 | 220 | 29721819 |
Parkinsonism | 10.80 | 10.68 | 25 | 230414 | 7244 | 29714795 |
Dermatitis exfoliative | 10.79 | 10.68 | 26 | 230413 | 7430 | 29714609 |
Dermatitis bullous | 10.77 | 10.68 | 19 | 230420 | 6085 | 29715954 |
Akathisia | 10.76 | 10.68 | 18 | 230421 | 5886 | 29716153 |
Blood potassium increased | 10.76 | 10.68 | 180 | 230259 | 16033 | 29706006 |
Arterial intramural haematoma | 10.76 | 10.68 | 6 | 230433 | 45 | 29721994 |
Source | Code | Description |
---|---|---|
ATC | C07AB02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, selective |
ATC | C07BB02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND THIAZIDES Beta blocking agents, selective, and thiazides |
ATC | C07BB52 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND THIAZIDES Beta blocking agents, selective, and thiazides |
ATC | C07CB02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND OTHER DIURETICS Beta blocking agents, selective, and other diuretics |
ATC | C07FB02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FB13 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FX03 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations |
ATC | C07FX05 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations |
FDA MoA | N0000000161 | Adrenergic beta-Antagonists |
FDA EPC | N0000175556 | beta-Adrenergic Blocker |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D058671 | Adrenergic beta-1 Receptor Antagonists |
MeSH PA | D000319 | Adrenergic beta-Antagonists |
MeSH PA | D000889 | Anti-Arrhythmia Agents |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D013565 | Sympatholytics |
CHEBI has role | CHEBI:35530 | beta-adrenoceptor antagonists |
CHEBI has role | CHEBI:35674 | antihypertensive |
CHEBI has role | CHEBI:35703 | xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Myocardial infarction | indication | 22298006 | DOID:5844 |
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Angina pectoris | indication | 194828000 | |
Acute coronary syndrome | indication | 394659003 | |
Myocardial Reinfarction Prevention | indication | ||
Supraventricular tachycardia | off-label use | 6456007 | |
Ventricular tachycardia | off-label use | 25569003 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Multifocal atrial tachycardia | off-label use | 49982000 | |
Paroxysmal supraventricular tachycardia | off-label use | 67198005 | |
Thyrotoxicosis | off-label use | 90739004 | DOID:7997 |
Paroxysmal atrial tachycardia | off-label use | 195069001 | |
Ectopic atrial tachycardia | off-label use | 233892002 | |
Mitral valve prolapse | off-label use | 409712001 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Migraine Prevention | off-label use | ||
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia | off-label use | ||
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation | off-label use | ||
Pheochromocytoma Adjunct Therapy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Bronchospasm | contraindication | 4386001 | |
Psoriasis | contraindication | 9014002 | DOID:8893 |
Hypercholesterolemia | contraindication | 13644009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Hypovolemia | contraindication | 28560003 | |
Dehydration | contraindication | 34095006 | |
Depressive disorder | contraindication | 35489007 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
Anaphylaxis | contraindication | 39579001 | |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Sinus bradycardia | contraindication | 49710005 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Cardiogenic shock | contraindication | 89138009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Hypomagnesemia | contraindication | 190855004 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypoglycemic disorder | contraindication | 237630007 | |
Raynaud's phenomenon | contraindication | 266261006 | |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Pheochromocytoma | contraindication | 302835009 | |
Peripheral arterial occlusive disease | contraindication | 399957001 | |
Peripheral vascular disease | contraindication | 400047006 | |
Poor metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 423629005 | |
Azotemia | contraindication | 445009001 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
First Degree Atrioventricular Heart Block | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.19 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.60 | WOMBAT-PK | CHEMBL | |||
Beta-2 adrenergic receptor | GPCR | Ki | 6.30 | WOMBAT-PK | |||||
Adrenergic receptor beta | GPCR | IC50 | 6.30 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Kd | 6.79 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Kd | 7.83 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5 | CHEMBL |
ID | Source |
---|---|
D00601 | KEGG_DRUG |
80274-67-5 | SECONDARY_CAS_RN |
4018393 | VANDF |
4019836 | VANDF |
4020875 | VANDF |
C0025859 | UMLSCUI |
CHEBI:6904 | CHEBI |
CHEMBL13 | ChEMBL_ID |
CHEMBL3989566 | ChEMBL_ID |
CHEMBL1200337 | ChEMBL_ID |
CHEMBL2356097 | ChEMBL_ID |
CHEMBL2062335 | ChEMBL_ID |
D008790 | MESH_DESCRIPTOR_UI |
DB00264 | DRUGBANK_ID |
4171 | PUBCHEM_CID |
553 | IUPHAR_LIGAND_ID |
3471 | INN_ID |
GEB06NHM23 | UNII |
102313 | RXNORM |
1073 | MMSL |
5102 | MMSL |
5103 | MMSL |
d00134 | MMSL |
001853 | NDDF |
003627 | NDDF |
003628 | NDDF |
004135 | NDDF |
372826007 | SNOMEDCT_US |
412432007 | SNOMEDCT_US |
7092007 | SNOMEDCT_US |
72770009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9660 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 26 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9873 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 26 sections |
TOPROLXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-1088 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | NDA | 27 sections |
TOPROLXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-1090 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | NDA | 27 sections |
TOPROLXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-1092 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA | 27 sections |
TOPROLXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-1094 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | NDA | 27 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0018 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0032 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0047 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0424 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
Metoprolol Tartrate and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0434 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Metoprolol Tartrate and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0445 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4593 | TABLET, FILM COATED | 37.50 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4594 | TABLET, FILM COATED | 75 mg | ORAL | ANDA | 23 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4595 | TABLET, FILM COATED, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 27 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4596 | TABLET, FILM COATED, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 27 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4597 | TABLET, FILM COATED, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 27 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4598 | TABLET, FILM COATED, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 27 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1778 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 31 sections |
METOPROLOL SUCCINULLTE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2600 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | NDA authorized generic | 27 sections |
METOPROLOL SUCCINULLTE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2601 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | NDA authorized generic | 27 sections |
METOPROLOL SUCCINULLTE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2602 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA authorized generic | 27 sections |
METOPROLOL SUCCINULLTE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2603 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | NDA authorized generic | 27 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-6547 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 14 sections |
Metoprolol succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7823 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 26 sections |
Metoprolol succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7824 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 26 sections |
Metoprolol succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7825 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 26 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8016 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8017 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8322 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 23 sections |