metoprolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 1786 51384-51-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metoprolol fumarate
  • metoprolol
  • metoprolol succinate
  • beatrolol
  • metoprolol tartrate
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
  • Molecular weight: 267.37
  • Formula: C15H25NO3
  • CLOGP: 1.49
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 50.72
  • ALOGS: -2.82
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 24.95 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 13 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.88 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1978 FDA US PHARMS HOLDINGS I

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1148.02 9.87 1903 314890 97990 63074239
Cardiac failure congestive 925.61 9.87 1657 315136 90776 63081453
Atrial fibrillation 891.52 9.87 1865 314928 114771 63057458
Pemphigus 841.34 9.87 15 316778 183711 62988518
Systemic lupus erythematosus 726.12 9.87 93 316700 208825 62963404
Synovitis 712.01 9.87 59 316734 186859 62985370
Hand deformity 699.27 9.87 21 316772 159436 63012793
Glossodynia 668.96 9.87 61 316732 178815 62993414
Bradycardia 659.00 9.87 1254 315539 71973 63100256
Coronary artery disease 629.25 9.87 792 316001 31585 63140644
Contraindicated product administered 620.95 9.87 160 316633 217488 62954741
Drug ineffective 591.08 9.87 2951 313842 1041814 62130415
Anti-cyclic citrullinated peptide antibody positive 561.60 9.87 3 316790 116209 63056020
Drug intolerance 549.54 9.87 441 316352 308220 62864009
Arthropathy 542.96 9.87 246 316547 234546 62937683
Treatment failure 520.65 9.87 172 316621 198871 62973358
Pericarditis 513.74 9.87 37 316756 131542 63040687
Infusion related reaction 490.41 9.87 310 316483 245211 62927018
Completed suicide 470.20 9.87 1697 315096 143976 63028253
Acute myocardial infarction 464.84 9.87 681 316112 31443 63140786
Joint swelling 422.26 9.87 613 316180 327053 62845176
Duodenal ulcer perforation 412.69 9.87 4 316789 87205 63085024
Hypotension 407.45 9.87 2538 314255 270066 62902163
Rheumatoid factor positive 394.27 9.87 5 316788 84401 63087828
Helicobacter infection 380.44 9.87 20 316773 92765 63079464
Therapeutic product effect decreased 368.00 9.87 257 316536 192930 62979299
Cerebrovascular accident 358.29 9.87 1270 315523 106754 63065475
Swelling 356.80 9.87 513 316280 274865 62897364
Lower respiratory tract infection 346.43 9.87 114 316679 132193 63040036
Wound 335.76 9.87 199 316594 163064 63009165
Hypersensitivity 332.35 9.87 595 316198 292090 62880139
Rheumatoid arthritis 319.82 9.87 482 316311 253337 62918892
Product prescribing error 305.80 9.87 504 316289 25785 63146444
Folliculitis 301.96 9.87 11 316782 70306 63101923
Maternal exposure during pregnancy 301.01 9.87 394 316399 219668 62952561
Alopecia 287.66 9.87 803 315990 336733 62835496
Off label use 283.79 9.87 2087 314706 672375 62499854
Syncope 281.71 9.87 1247 315546 116138 63056091
Muscle injury 274.58 9.87 12 316781 65333 63106896
Cardiac disorder 271.87 9.87 707 316086 50109 63122120
Hepatic enzyme increased 268.82 9.87 370 316423 201958 62970271
Discomfort 265.33 9.87 266 316527 167108 63005121
Abdominal discomfort 249.16 9.87 797 315996 320088 62852141
Pain 239.31 9.87 2454 314339 738174 62434055
Product use issue 236.32 9.87 464 316329 220056 62952173
Dizziness 229.13 9.87 3206 313587 426719 62745510
Fall 223.88 9.87 2962 313831 389372 62782857
Rash 211.16 9.87 1788 315005 559083 62613146
Product monitoring error 200.16 9.87 172 316621 4344 63167885
Irritable bowel syndrome 197.17 9.87 82 316711 82330 63089899
Gastrointestinal haemorrhage 192.89 9.87 860 315933 80316 63091913
Dyspnoea 183.57 9.87 4453 312340 656860 62515369
Coronary artery bypass 176.95 9.87 123 316670 2246 63169983
Blister 175.76 9.87 234 316559 129580 63042649
Palpitations 175.64 9.87 1062 315731 111708 63060521
Angina pectoris 174.94 9.87 432 316361 29646 63142583
BRASH syndrome 173.63 9.87 71 316722 398 63171831
Death 172.34 9.87 2723 314070 371658 62800571
Suspected suicide 168.00 9.87 185 316608 6383 63165846
Cardiogenic shock 166.01 9.87 311 316482 17621 63154608
Sinus bradycardia 165.23 9.87 276 316517 14275 63157954
Cardiac failure 163.48 9.87 877 315916 88265 63083964
Arthralgia 162.40 9.87 1941 314852 567769 62604460
Pyrexia 162.33 9.87 1533 315260 468945 62703284
Sleep disorder due to general medical condition, insomnia type 161.53 9.87 32 316761 52185 63120044
C-reactive protein abnormal 158.81 9.87 21 316772 46075 63126154
Drug interaction 155.51 9.87 1788 315005 227343 62944886
Renal failure 153.77 9.87 1060 315733 116592 63055637
Dehydration 152.36 9.87 1426 315367 171928 63000301
Cardiac arrest 146.94 9.87 876 315917 91669 63080560
Musculoskeletal stiffness 142.78 9.87 459 316334 184159 62988070
International normalised ratio increased 142.11 9.87 532 316261 45893 63126336
Arrhythmia 140.86 9.87 465 316328 37675 63134554
Sensitisation 140.08 9.87 124 316669 3262 63168967
Coronary arterial stent insertion 136.18 9.87 113 316680 2716 63169513
Infection 134.80 9.87 636 316157 228537 62943692
Acute kidney injury 134.63 9.87 1951 314842 261464 62910765
Ejection fraction 132.56 9.87 104 316689 2302 63169927
Angina unstable 132.17 9.87 170 316623 6925 63165304
Ill-defined disorder 131.70 9.87 128 316665 81627 63090602
Exposure during pregnancy 131.55 9.87 371 316422 155176 63017053
Labelled drug-drug interaction medication error 131.09 9.87 238 316555 13161 63159068
Oedema peripheral 122.39 9.87 1465 315328 188046 62984183
Hip arthroplasty 121.27 9.87 43 316750 47603 63124626
Impaired healing 118.39 9.87 206 316587 102336 63069893
Haematochezia 115.86 9.87 552 316241 52992 63119237
Liver injury 115.79 9.87 80 316713 60440 63111789
Gastrointestinal disorder 113.96 9.87 309 316484 130930 63041299
Asthenia 113.62 9.87 2608 314185 380996 62791233
Abortion spontaneous 111.20 9.87 48 316745 47147 63125082
Polycystic ovaries 111.02 9.87 124 316669 4347 63167882
Pulmonary oedema 109.66 9.87 553 316240 54320 63117909
Pregnancy 108.97 9.87 25 316768 36811 63135418
Blood pressure increased 106.90 9.87 1258 315535 160804 63011425
Drug hypersensitivity 106.67 9.87 1013 315780 309674 62862555
General physical health deterioration 106.13 9.87 1500 315293 199902 62972327
Sinusitis 105.85 9.87 679 316114 225974 62946255
Toxicity to various agents 105.24 9.87 1776 315017 245474 62926755
C-reactive protein increased 105.08 9.87 195 316598 94512 63077717
Anaemia 100.97 9.87 2039 314754 291391 62880838
Chest pain 99.23 9.87 1571 315222 214388 62957841
Psoriatic arthropathy 98.41 9.87 192 316601 91328 63080901
Anti-neutrophil cytoplasmic antibody positive vasculitis 98.28 9.87 95 316698 2804 63169425
Red blood cell sedimentation rate increased 97.04 9.87 49 316744 43933 63128296
Haemoglobin decreased 93.59 9.87 1124 315669 144361 63027868
Atrioventricular block 93.52 9.87 150 316643 7497 63164732
Inflammation 92.51 9.87 168 316625 82105 63090124
Mobility decreased 91.71 9.87 304 316489 120855 63051374
Hypertensive crisis 90.42 9.87 221 316572 15065 63157164
Type 2 diabetes mellitus 88.59 9.87 113 316680 63755 63108474
Ventricular tachycardia 88.01 9.87 259 316534 19720 63152509
Blood pressure inadequately controlled 87.63 9.87 116 316677 4862 63167367
Blood test abnormal 86.18 9.87 220 316573 15409 63156820
Hyperkalaemia 85.95 9.87 513 316280 53690 63118539
Blood loss anaemia 85.68 9.87 158 316635 8843 63163386
Intentional product use issue 85.48 9.87 338 316455 127554 63044675
Atrioventricular block complete 83.84 9.87 149 316644 8102 63164127
Lactic acidosis 83.76 9.87 396 316397 37891 63134338
Diarrhoea 79.69 9.87 4345 312448 711021 62461208
Hyponatraemia 79.31 9.87 881 315912 111019 63061210
Febrile neutropenia 79.19 9.87 313 316480 118136 63054093
Product substitution issue 76.90 9.87 214 316579 15782 63156447
Blood creatinine increased 76.28 9.87 721 316072 87123 63085106
Plasma cell myeloma 76.11 9.87 368 316425 35537 63136692
Device expulsion 73.96 9.87 41 316752 34881 63137348
Renal disorder 73.56 9.87 343 316450 32631 63139598
Condition aggravated 73.29 9.87 1491 315302 400726 62771503
Nodal rhythm 72.44 9.87 64 316729 1679 63170550
Blood cholesterol increased 71.10 9.87 236 316557 93796 63078433
Stomatitis 70.79 9.87 404 316389 138321 63033908
Atrial flutter 70.74 9.87 153 316640 9619 63162610
Red blood cell sedimentation rate abnormal 70.62 9.87 8 316785 19774 63152455
Product administration error 70.48 9.87 259 316534 22138 63150091
Unresponsive to stimuli 69.82 9.87 344 316449 33472 63138757
Product use in unapproved indication 69.74 9.87 565 316228 178515 62993714
Nasopharyngitis 68.85 9.87 875 315918 253382 62918847
Coronary artery occlusion 68.39 9.87 136 316657 8055 63164174
Chronic kidney disease 68.38 9.87 424 316369 44974 63127255
Acute coronary syndrome 68.17 9.87 154 316639 9972 63162257
Myocardial ischaemia 67.81 9.87 178 316615 12681 63159548
Renal impairment 66.01 9.87 703 316090 87652 63084577
Ventricular fibrillation 65.39 9.87 167 316626 11700 63160529
Drug resistance 65.03 9.87 17 316776 22916 63149313
Hypertensive emergency 64.42 9.87 62 316731 1820 63170409
Hepatic cytolysis 64.16 9.87 3 316790 15404 63156825
Drug abuse 63.48 9.87 170 316623 72348 63099881
Pulmonary renal syndrome 63.08 9.87 35 316758 419 63171810
Presyncope 62.70 9.87 290 316503 27495 63144734
Drug tolerance decreased 62.54 9.87 7 316786 17466 63154763
Knee arthroplasty 62.45 9.87 109 316684 54097 63118132
Neutropenia 62.39 9.87 565 316228 174440 62997789
Interstitial lung disease 60.56 9.87 137 316656 61771 63110458
Mental status changes 59.12 9.87 369 316424 39230 63132999
Medication error 59.03 9.87 455 316338 51829 63120400
Blood pressure decreased 58.10 9.87 537 316256 64485 63107744
Rhinitis allergic 57.48 9.87 158 316635 11569 63160660
Ischaemic stroke 56.80 9.87 208 316585 17749 63154480
Atrioventricular block first degree 56.26 9.87 117 316676 7156 63165073
Dyspnoea exertional 54.38 9.87 499 316294 59803 63112426
Migraine 54.33 9.87 298 316495 103048 63069181
Pulmonary hypertension 54.22 9.87 344 316449 36779 63135450
Ejection fraction abnormal 54.04 9.87 55 316738 1730 63170499
Haematoma 53.57 9.87 327 316466 34493 63137736
Transient ischaemic attack 53.39 9.87 347 316446 37406 63134823
Drug reaction with eosinophilia and systemic symptoms 53.30 9.87 54 316739 33782 63138447
Heart rate irregular 52.81 9.87 237 316556 22184 63150045
Hypoglycaemia 52.63 9.87 494 316299 59571 63112658
Bone erosion 52.45 9.87 12 316781 17705 63154524
Sleep apnoea syndrome 52.27 9.87 285 316508 28848 63143381
Cerebral haemorrhage 52.06 9.87 296 316497 30433 63141796
Rhabdomyolysis 51.02 9.87 385 316408 43566 63128663
Therapeutic drug monitoring analysis not performed 50.98 9.87 47 316746 1305 63170924
Lower gastrointestinal haemorrhage 50.91 9.87 118 316675 7772 63164457
Peripheral arterial occlusive disease 50.82 9.87 82 316711 4119 63168110
Mitral valve incompetence 50.65 9.87 213 316580 19381 63152848
Full blood count decreased 50.39 9.87 260 316533 25764 63146465
Live birth 50.20 9.87 33 316760 25597 63146632
Urinary tract infection 49.61 9.87 1698 315095 262986 62909243
Tachycardia 49.55 9.87 847 315946 117309 63054920
Therapy non-responder 49.18 9.87 203 316590 75698 63096531
Loss of employment 48.60 9.87 58 316735 2186 63170043
Ventricular extrasystoles 48.17 9.87 148 316645 11539 63160690
Orthostatic intolerance 47.86 9.87 43 316750 1154 63171075
Grip strength decreased 47.43 9.87 26 316767 22261 63149968
Coronary artery stenosis 47.34 9.87 85 316708 4659 63167570
Urticaria 47.34 9.87 564 316229 165238 63006991
Thrombosis 46.86 9.87 512 316281 64243 63107986
Heart rate increased 46.45 9.87 694 316099 93544 63078685
Rheumatoid nodule 46.26 9.87 14 316779 17141 63155088
Product dose omission issue 46.15 9.87 1512 315281 232801 62939428
Tachyarrhythmia 46.04 9.87 81 316712 4369 63167860
Gout 45.63 9.87 158 316635 13113 63159116
Deep vein thrombosis 45.63 9.87 628 316165 83172 63089057
Hypertension 45.57 9.87 1764 315029 277539 62894690
Heart rate decreased 45.20 9.87 385 316408 45175 63127054
Torsade de pointes 45.08 9.87 158 316635 13193 63159036
Nephrectomy 44.81 9.87 46 316747 1462 63170767
Vascular graft 43.51 9.87 35 316758 804 63171425
Nephrogenic systemic fibrosis 43.39 9.87 80 316713 4476 63167753
Erythema 43.13 9.87 617 316176 175134 62997095
Cardiac failure acute 42.47 9.87 124 316669 9399 63162830
Suicidal ideation 42.31 9.87 164 316629 62257 63109972
Sedation complication 41.65 9.87 9 316784 13813 63158416
Facet joint syndrome 40.70 9.87 6 316787 12132 63160097
Supraventricular tachycardia 39.94 9.87 159 316634 14112 63158117
Bradyarrhythmia 39.90 9.87 51 316742 2064 63170165
Hypersensitivity myocarditis 39.50 9.87 20 316773 196 63172033
Adjustment disorder with depressed mood 39.42 9.87 3 316790 10201 63162028
Hip fracture 39.32 9.87 267 316526 29207 63143022
Neonatal respiratory failure 39.11 9.87 22 316771 271 63171958
Hypothyroidism 39.05 9.87 354 316439 42278 63129951
Cardiac output decreased 39.02 9.87 35 316758 937 63171292
Pruritus 38.70 9.87 1444 315349 360009 62812220
Sinus node dysfunction 38.17 9.87 77 316716 4608 63167621
Decorticate posture 38.15 9.87 22 316771 285 63171944
Epistaxis 37.98 9.87 541 316252 72184 63100045
Blood potassium decreased 37.50 9.87 347 316446 41679 63130550
Hypervolaemia 37.08 9.87 256 316537 28157 63144072
Abortion induced 36.92 9.87 4 316789 10238 63161991
Cardiovascular disorder 36.67 9.87 136 316657 11676 63160553
Acute respiratory failure 36.66 9.87 296 316497 34189 63138040
Renal injury 36.57 9.87 117 316676 9322 63162907
Congenital hydronephrosis 36.51 9.87 24 316769 398 63171831
Heart rate abnormal 36.43 9.87 78 316715 4869 63167360
Body tinea 36.43 9.87 46 316747 1839 63170390
Intestinal malrotation 36.30 9.87 23 316770 357 63171872
Carpal tunnel syndrome 36.24 9.87 202 316591 20615 63151614
Lip dry 36.02 9.87 16 316777 15454 63156775
Myelosuppression 36.01 9.87 39 316754 23664 63148565
Patent ductus arteriosus 36.01 9.87 71 316722 4179 63168050
Hepatic function abnormal 35.67 9.87 83 316710 37059 63135170
Bundle branch block left 35.48 9.87 96 316697 6963 63165266
Cardiac pacemaker insertion 35.04 9.87 69 316724 4057 63168172
Arterial haemorrhage 34.94 9.87 43 316750 1674 63170555
Myocardial depression 34.93 9.87 25 316768 479 63171750
Pleural effusion 34.77 9.87 656 316137 92554 63079675
Hiatus hernia 34.62 9.87 205 316588 21389 63150840
Hepatotoxicity 34.60 9.87 84 316709 36957 63135272
Sopor 34.20 9.87 36 316757 22128 63150101
Haemorrhage 33.91 9.87 459 316334 60563 63111666
Congenital aortic valve stenosis 33.84 9.87 13 316780 60 63172169
Therapeutic response decreased 33.66 9.87 175 316618 61350 63110879
Acute left ventricular failure 33.52 9.87 34 316759 1065 63171164
Listless 33.48 9.87 55 316738 2805 63169424
Anaphylactic reaction 33.43 9.87 193 316600 65907 63106322
Joint range of motion decreased 33.17 9.87 70 316723 32358 63139871
Dementia 33.14 9.87 183 316610 18611 63153618
Panniculitis 33.13 9.87 8 316785 11377 63160852
Hypothermia 33.07 9.87 145 316648 13436 63158793
Internal haemorrhage 33.05 9.87 77 316716 5088 63167141
Arteriosclerosis 33.02 9.87 118 316675 9948 63162281
Atrioventricular block second degree 32.69 9.87 65 316728 3849 63168380
Bronchiectasis 32.69 9.87 20 316773 16122 63156107
Ischaemic cardiomyopathy 32.24 9.87 50 316743 2427 63169802
Hypokalaemia 31.93 9.87 710 316083 103094 63069135
Sleep disorder due to a general medical condition 31.90 9.87 133 316660 12055 63160174
Haemophagocytic lymphohistiocytosis 31.86 9.87 7 316786 10620 63161609
Fibromyalgia 31.61 9.87 253 316540 80167 63092062
Glomerular filtration rate decreased 31.60 9.87 142 316651 13299 63158930
Blood glucose increased 31.42 9.87 590 316203 83166 63089063
Ventricular arrhythmia 31.29 9.87 63 316730 3765 63168464
Body height decreased 31.25 9.87 116 316677 9962 63162267
Granuloma skin 31.18 9.87 3 316790 8434 63163795
Injection site reaction 31.16 9.87 168 316625 58356 63113873
Neutropenic sepsis 31.08 9.87 22 316771 16416 63155813
Hyperlipidaemia 30.87 9.87 185 316608 19386 63152843
Cardiomegaly 30.72 9.87 171 316622 17443 63154786
Wrong product administered 30.35 9.87 83 316710 6058 63166171
Cytomegalovirus infection 30.17 9.87 36 316757 20916 63151313
Nodal arrhythmia 30.16 9.87 33 316760 1130 63171099
Weight increased 30.13 9.87 1032 315761 259760 62912469
Blood urea increased 30.01 9.87 230 316563 26149 63146080
Skin induration 29.95 9.87 56 316737 3167 63169062
Hypertensive heart disease 29.85 9.87 48 316745 2404 63169825
Aortic valve incompetence 29.67 9.87 81 316712 5907 63166322
Hypomagnesaemia 29.65 9.87 245 316548 28492 63143737
Conjoined twins 29.41 9.87 18 316775 262 63171967
Injection site pain 29.32 9.87 463 316330 129337 63042892
Ageusia 29.30 9.87 141 316652 13587 63158642
Drug eruption 29.30 9.87 62 316731 28632 63143597
Hepatitis 29.29 9.87 101 316692 39687 63132542
Coagulopathy 29.15 9.87 189 316604 20355 63151874
Arteriosclerosis coronary artery 29.06 9.87 100 316693 8273 63163956
Aortic valve stenosis 29.03 9.87 56 316737 3243 63168986
Mucosal inflammation 28.87 9.87 128 316665 46800 63125429
Poisoning deliberate 28.76 9.87 10 316783 11208 63161021
Liver disorder 28.65 9.87 154 316639 53533 63118696
Device capturing issue 28.63 9.87 10 316783 33 63172196
Diverticulum intestinal 28.59 9.87 86 316707 6627 63165602
Foot deformity 28.59 9.87 60 316733 27793 63144436
Electrocardiogram T wave abnormal 28.56 9.87 47 316746 2400 63169829
Fluid retention 28.42 9.87 437 316356 59249 63112980
Inhibitory drug interaction 28.37 9.87 51 316742 2798 63169431
Acute generalised exanthematous pustulosis 28.27 9.87 10 316783 11089 63161140
Lung disorder 28.26 9.87 188 316605 62073 63110156
Cardiomyopathy 28.23 9.87 167 316626 17417 63154812
Electrolyte imbalance 28.06 9.87 184 316609 19892 63152337
Pulmonary fibrosis 28.01 9.87 103 316690 39706 63132523
Immunodeficiency 27.91 9.87 36 316757 20218 63152011
Colitis ulcerative 27.81 9.87 55 316738 26036 63146193
Atrial septal defect 27.80 9.87 87 316706 6851 63165378
Glucose tolerance impaired 27.77 9.87 84 316709 6493 63165736
Anuria 27.58 9.87 130 316663 12421 63159808
Gouty arthritis 27.54 9.87 23 316770 558 63171671
Melaena 27.23 9.87 251 316542 30114 63142115
Electrocardiogram QRS complex prolonged 27.13 9.87 78 316715 5860 63166369
Haemarthrosis 27.01 9.87 53 316740 3108 63169121
Coronary artery dissection 26.90 9.87 27 316766 835 63171394
Labile hypertension 26.76 9.87 21 316772 465 63171764
Cardiac ablation 26.75 9.87 35 316758 1450 63170779
Cardiorenal syndrome 26.56 9.87 27 316766 848 63171381
Headache 26.54 9.87 2761 314032 630480 62541749
Mitral valve stenosis 26.45 9.87 31 316762 1146 63171083
Blood parathyroid hormone decreased 26.38 9.87 8 316785 9783 63162446
Ventricular hypokinesia 26.26 9.87 66 316727 4578 63167651
Decreased appetite 26.22 9.87 1517 315276 249535 62922694
Pallor 26.07 9.87 250 316543 30318 63141911
Hypovolaemia 26.03 9.87 114 316679 10559 63161670
End stage renal disease 25.96 9.87 83 316710 6610 63165619
Muscle spasticity 25.86 9.87 43 316750 21751 63150478
Heparin-induced thrombocytopenia 25.78 9.87 65 316728 4517 63167712
Myocardial hypoxia 25.73 9.87 8 316785 16 63172213
Venous pressure jugular increased 25.62 9.87 22 316771 555 63171674
Orthopnoea 25.54 9.87 79 316714 6182 63166047
Drug level increased 25.18 9.87 197 316596 22539 63149690
Intraventricular haemorrhage 25.13 9.87 41 316752 2079 63170150
Eructation 25.08 9.87 95 316698 8238 63163991
Therapeutic product effect incomplete 25.02 9.87 456 316337 124600 63047629
Maternal exposure timing unspecified 24.96 9.87 3 316790 7084 63165145
Lymphocyte count decreased 24.94 9.87 73 316720 30184 63142045
Prescribed overdose 24.93 9.87 87 316706 34066 63138163
Hepatocellular injury 24.86 9.87 63 316730 27318 63144911
Sudden cardiac death 24.84 9.87 41 316752 2099 63170130
Gastrointestinal tract mucosal pigmentation 24.81 9.87 22 316771 580 63171649
Allergic reaction to excipient 24.71 9.87 18 316775 355 63171874
Pneumocystis jirovecii pneumonia 24.42 9.87 29 316764 16885 63155344
Head injury 24.33 9.87 226 316567 27170 63145059
Angioedema 24.32 9.87 355 316438 47610 63124619
Cerebral infarction 24.28 9.87 203 316590 23690 63148539
Rash maculo-papular 24.14 9.87 80 316713 31816 63140413
Infective pulmonary exacerbation of cystic fibrosis 24.13 9.87 7 316786 8810 63163419
Urinary retention 23.99 9.87 244 316549 30057 63142172
Aortic stenosis 23.97 9.87 67 316726 4953 63167276
Progressive multifocal leukoencephalopathy 23.69 9.87 18 316775 12953 63159276
Schizophrenia 23.64 9.87 10 316783 9942 63162287
Product solubility abnormal 23.59 9.87 25 316768 825 63171404
Fear 23.58 9.87 147 316646 15619 63156610
Device dislocation 23.45 9.87 59 316734 25646 63146583
Gastrointestinal toxicity 23.41 9.87 5 316788 7736 63164493
Blue toe syndrome 23.31 9.87 18 316775 389 63171840
Dystonia 22.99 9.87 21 316772 13798 63158431
Pulseless electrical activity 22.85 9.87 86 316707 7435 63164794
Vitello-intestinal duct remnant 22.85 9.87 9 316784 45 63172184
Extrasystoles 22.83 9.87 67 316726 5093 63167136
Maternal exposure before pregnancy 22.81 9.87 5 316788 7598 63164631
Haemorrhage intracranial 22.56 9.87 129 316664 13290 63158939
Body temperature increased 22.54 9.87 102 316691 37090 63135139
Unevaluable event 22.49 9.87 371 316422 51015 63121214
Congenital bladder anomaly 22.37 9.87 13 316780 171 63172058
Troponin increased 22.36 9.87 105 316688 10016 63162213
Cardio-respiratory arrest 22.36 9.87 422 316371 59537 63112692
Electrocardiogram abnormal 22.35 9.87 98 316695 9081 63163148
Stress cardiomyopathy 22.34 9.87 100 316693 9350 63162879
Chronic obstructive pulmonary disease 22.29 9.87 438 316355 62248 63109981
Myxoedema coma 22.25 9.87 18 316775 417 63171812
Flatulence 22.23 9.87 268 316525 34434 63137795
Subchondral insufficiency fracture 22.22 9.87 9 316784 49 63172180
Vascular resistance pulmonary decreased 22.14 9.87 10 316783 74 63172155
Tendonitis 22.09 9.87 40 316753 19575 63152654
Incorrect route of product administration 22.07 9.87 67 316726 27385 63144844
Hyperthermia 22.07 9.87 9 316784 9147 63163082
Therapy partial responder 21.87 9.87 13 316780 10645 63161584
Urachal abnormality 21.86 9.87 13 316780 179 63172050
Haematuria 21.76 9.87 232 316561 28925 63143304
Embolic stroke 21.70 9.87 54 316739 3722 63168507
Blood pressure abnormal 21.67 9.87 140 316653 15058 63157171
Cardioversion 21.62 9.87 29 316764 1231 63170998
Bicuspid aortic valve 21.53 9.87 11 316782 110 63172119
Electrocardiogram RR interval prolonged 21.53 9.87 5 316788 0 63172229
Phaeochromocytoma 21.46 9.87 19 316774 500 63171729
International normalised ratio decreased 21.42 9.87 60 316733 4441 63167788
Rectourethral fistula 21.35 9.87 8 316785 34 63172195
Haemorrhoidal haemorrhage 21.32 9.87 58 316735 4221 63168008
Cerebrospinal fluid retention 21.27 9.87 10 316783 82 63172147
Chloropsia 21.16 9.87 8 316785 35 63172194
Persistent cloaca 21.07 9.87 13 316780 192 63172037
Embolic cerebral infarction 21.02 9.87 19 316774 514 63171715
Neutrophil count decreased 21.01 9.87 180 316613 56226 63116003
Diverticulum intestinal haemorrhagic 21.01 9.87 32 316761 1529 63170700
CD30 expression 20.99 9.87 8 316785 36 63172193
Phaeochromocytoma crisis 20.95 9.87 14 316779 239 63171990
Infection susceptibility increased 20.92 9.87 51 316742 3470 63168759
Post procedural haemorrhage 20.92 9.87 87 316706 7877 63164352
Respiratory disorder 20.91 9.87 112 316681 38970 63133259
Sinus arrest 20.84 9.87 36 316757 1913 63170316
Device stimulation issue 20.84 9.87 9 316784 59 63172170
Arrhythmia neonatal 20.81 9.87 8 316785 37 63172192
Fryns syndrome 20.72 9.87 9 316784 60 63172169
Coeliac disease 20.64 9.87 20 316773 12777 63159452
Occult blood positive 20.59 9.87 52 316741 3618 63168611
Shock 20.56 9.87 193 316600 23270 63148959
Unintentional medical device removal 20.56 9.87 3 316790 6112 63166117
Cardiac valve disease 20.55 9.87 57 316736 4195 63168034
Sleep disorder 20.47 9.87 285 316508 81281 63090948
Hypoacusis 20.34 9.87 197 316596 23954 63148275
Femoral hernia incarcerated 20.33 9.87 23 316770 818 63171411
Chromaturia 20.28 9.87 148 316645 16569 63155660
Splenic rupture 20.27 9.87 29 316764 1309 63170920
Mouth ulceration 20.27 9.87 90 316703 32894 63139335
Ischaemic cerebral infarction 20.14 9.87 29 316764 1317 63170912
Anhedonia 20.12 9.87 108 316685 10866 63161363
Congenital choroid plexus cyst 19.99 9.87 15 316778 310 63171919
Product residue present 19.89 9.87 54 316739 3925 63168304
Lymphatic fistula 19.86 9.87 22 316771 764 63171465
Supraventricular extrasystoles 19.74 9.87 59 316734 4530 63167699
Respiratory failure 19.69 9.87 656 316137 101202 63071027
Hospice care 19.55 9.87 85 316708 7847 63164382
HELLP syndrome 19.42 9.87 25 316768 1019 63171210
Non-cardiogenic pulmonary oedema 19.41 9.87 21 316772 710 63171519
Malignant polyp 19.35 9.87 12 316781 179 63172050
Hypoxia 19.35 9.87 412 316381 59380 63112849
Echocardiogram abnormal 19.30 9.87 29 316764 1369 63170860
Disability 19.27 9.87 39 316754 18308 63153921
Alveolitis 19.25 9.87 44 316749 2871 63169358
Bone marrow failure 19.18 9.87 78 316715 29212 63143017
Amenorrhoea 19.10 9.87 13 316780 9901 63162328
Congenital acrochordon 18.98 9.87 8 316785 49 63172180
Cardioactive drug level increased 18.94 9.87 37 316756 2163 63170066
Blood albumin abnormal 18.91 9.87 18 316775 521 63171708
Wound infection 18.87 9.87 50 316743 21360 63150869
Renal impairment neonatal 18.84 9.87 8 316785 50 63172179
Prothrombin time prolonged 18.83 9.87 96 316697 9468 63162761
Stent placement 18.81 9.87 51 316742 3704 63168525
Atrial thrombosis 18.69 9.87 33 316760 1785 63170444
Burning sensation 18.62 9.87 378 316415 54029 63118200
Pulse absent 18.49 9.87 64 316729 5310 63166919
Ultrasound kidney abnormal 18.45 9.87 7 316786 31 63172198
Ovarian cyst 18.42 9.87 32 316761 15913 63156316
Lupus-like syndrome 18.31 9.87 30 316763 15265 63156964
Electrocardiogram T wave inversion 18.16 9.87 48 316745 3433 63168796
Metabolic acidosis 18.13 9.87 321 316472 44748 63127481
Neutrophil function disorder 18.12 9.87 6 316787 16 63172213
Upper gastrointestinal haemorrhage 18.01 9.87 158 316635 18694 63153535
Arteriovenous fistula occlusion 17.96 9.87 15 316778 364 63171865
Breast cancer stage I 17.90 9.87 6 316787 6883 63165346
Vaginal discharge 17.80 9.87 12 316781 9186 63163043
Cardiac operation 17.74 9.87 46 316747 3252 63168977
Intentional self-injury 17.72 9.87 67 316726 25620 63146609
Autoimmune disorder 17.63 9.87 37 316756 17140 63155089
Faeces discoloured 17.62 9.87 155 316638 18354 63153875
Left-to-right cardiac shunt 17.58 9.87 10 316783 126 63172103
Subdural haematoma 17.47 9.87 127 316666 14201 63158028
Left ventricular dysfunction 17.45 9.87 111 316682 11877 63160352
Pericardial haemorrhage 17.44 9.87 30 316763 1589 63170640
Asthma 17.33 9.87 494 316299 127067 63045162
Product quality issue 17.23 9.87 263 316530 35602 63136627
Negative cardiac inotropic effect 17.22 9.87 4 316789 0 63172229
Adrenalectomy 17.22 9.87 4 316789 0 63172229
Congenital nail disorder 17.20 9.87 9 316784 95 63172134
Left ventricular hypertrophy 17.17 9.87 62 316731 5253 63166976
Cholestasis 17.08 9.87 82 316711 29352 63142877
Arteriospasm coronary 17.06 9.87 51 316742 3917 63168312
Joint destruction 17.04 9.87 5 316788 6247 63165982
Hypoaesthesia 17.04 9.87 677 316116 167716 63004513
Dysphagia 16.99 9.87 570 316223 88015 63084214
Enterocolitis 16.97 9.87 9 316784 7849 63164380
Pancreatic steatosis 16.85 9.87 23 316770 993 63171236
Joint stiffness 16.78 9.87 131 316662 41738 63130491
Aortic valve sclerosis 16.78 9.87 25 316768 1171 63171058
Bursitis 16.73 9.87 112 316681 36929 63135300
Sedation 16.71 9.87 119 316674 38690 63133539
International normalised ratio abnormal 16.67 9.87 45 316748 3259 63168970
Tachycardia induced cardiomyopathy 16.65 9.87 9 316784 102 63172127
Hyperammonaemia 16.62 9.87 3 316790 5229 63167000
Essential hypertension 16.51 9.87 59 316734 4974 63167255
Aortic arteriosclerosis 16.44 9.87 68 316725 6141 63166088
Computerised tomogram head abnormal 16.42 9.87 5 316788 9 63172220
Metastases to bone 16.40 9.87 52 316741 20967 63151262
Thrombin time prolonged 16.35 9.87 9 316784 106 63172123
Multiple-drug resistance 16.34 9.87 3 316790 5167 63167062
Ischaemic hepatitis 16.32 9.87 34 316759 2082 63170147
Exostosis 16.29 9.87 41 316752 17821 63154408
Blood sodium decreased 16.29 9.87 189 316604 24063 63148166
Foreign body 16.23 9.87 36 316757 2302 63169927
Aortic aneurysm 16.14 9.87 49 316744 3795 63168434
Circulatory collapse 16.11 9.87 174 316619 21764 63150465
Dialysis 16.08 9.87 98 316695 10329 63161900
Urosepsis 16.05 9.87 152 316641 18372 63153857
Lymphopenia 16.01 9.87 43 316750 18284 63153945
Skin hypertrophy 15.94 9.87 45 316748 3346 63168883
Stent malfunction 15.92 9.87 8 316785 77 63172152
Lacunar infarction 15.88 9.87 44 316749 3236 63168993
Gastritis erosive 15.88 9.87 66 316727 5973 63166256
Eye haemorrhage 15.84 9.87 84 316709 8412 63163817
Female genital tract fistula 15.82 9.87 9 316784 7550 63164679
Blood potassium increased 15.74 9.87 150 316643 18159 63154070
Glomerulonephritis rapidly progressive 15.72 9.87 22 316771 973 63171256
Myocardial necrosis marker increased 15.72 9.87 31 316762 1825 63170404
Hepatic cyst 15.71 9.87 59 316734 5095 63167134
Haemodialysis 15.69 9.87 87 316706 8860 63163369
Hypomania 15.62 9.87 6 316787 6324 63165905
Chronic sinusitis 15.55 9.87 25 316768 12818 63159411
Hypocapnia 15.54 9.87 14 316779 377 63171852
Congenital diaphragmatic hernia 15.54 9.87 11 316782 207 63172022
Feeling abnormal 15.53 9.87 897 315896 147495 63024734
Device difficult to use 15.41 9.87 25 316768 12771 63159458
Conjunctival haemorrhage 15.32 9.87 46 316747 3541 63168688
Electrocardiogram QRS complex shortened 15.21 9.87 15 316778 454 63171775
Mitral valve sclerosis 15.19 9.87 9 316784 123 63172106
Oesophagitis chemical 15.19 9.87 5 316788 13 63172216
Alpha hydroxybutyrate dehydrogenase increased 15.19 9.87 5 316788 13 63172216
Injection site erythema 15.18 9.87 308 316485 82866 63089363
Loss of consciousness 15.18 9.87 728 316065 117393 63054836
Dysgeusia 15.16 9.87 322 316471 46388 63125841
Metastases to fallopian tube 15.14 9.87 7 316786 55 63172174
Gastric ulcer 15.12 9.87 185 316608 23852 63148377
Tooth erosion 15.10 9.87 15 316778 458 63171771
Alanine aminotransferase increased 15.09 9.87 398 316395 103372 63068857
Procedural pain 15.04 9.87 56 316737 21513 63150716
Drug therapeutic incompatibility 15.04 9.87 7 316786 56 63172173
Cardiac valve abscess 15.00 9.87 4 316789 3 63172226
Haemorrhagic stroke 15.00 9.87 63 316730 5729 63166500
Peritonitis bacterial 15.00 9.87 56 316737 4823 63167406
Small for dates baby 14.99 9.87 47 316746 3704 63168525
Diverticulitis 14.95 9.87 279 316514 39278 63132951
Pseudolymphoma 14.86 9.87 17 316776 612 63171617
Newborn persistent pulmonary hypertension 14.80 9.87 11 316782 224 63172005
Carotid artery stenosis 14.79 9.87 58 316735 5112 63167117
Spinal cord haematoma 14.75 9.87 10 316783 175 63172054
Haematotoxicity 14.72 9.87 15 316778 9361 63162868
Malignant neoplasm progression 14.72 9.87 305 316488 81816 63090413
Bundle branch block bilateral 14.67 9.87 5 316788 15 63172214
Hallucination, visual 14.61 9.87 154 316639 19144 63153085
Sodium retention 14.59 9.87 9 316784 133 63172096
Vascular stent thrombosis 14.54 9.87 21 316772 956 63171273
Reduced facial expression 14.48 9.87 31 316762 1935 63170294
Cerebral artery occlusion 14.45 9.87 20 316773 875 63171354
Blood pressure systolic abnormal 14.45 9.87 28 316765 13358 63158871
Traumatic haemorrhage 14.39 9.87 16 316777 558 63171671
Tuberculosis 14.37 9.87 21 316772 11190 63161039
Hypertensive nephropathy 14.36 9.87 17 316776 635 63171594
Lower limb fracture 14.34 9.87 67 316726 24154 63148075
Fear of injection 14.34 9.87 9 316784 7155 63165074
Subarachnoid haemorrhage 14.32 9.87 121 316672 14162 63158067
Pathogen resistance 14.30 9.87 7 316786 6391 63165838
Cardiac fibrillation 14.28 9.87 15 316778 490 63171739
Kyphosis 14.26 9.87 36 316757 2504 63169725
Pregnancy with contraceptive device 14.26 9.87 3 316790 4691 63167538
Adverse event 14.25 9.87 244 316549 67315 63104914
Sepsis 14.24 9.87 916 315877 152207 63020022
Pneumonia 14.17 9.87 2537 314256 454230 62717999
Nephropathy 14.17 9.87 66 316727 6275 63165954
Subclavian vein thrombosis 14.15 9.87 30 316763 1860 63170369
Conjunctival cyst 14.15 9.87 7 316786 65 63172164
Brain contusion 14.14 9.87 16 316777 569 63171660
Poor quality sleep 14.13 9.87 157 316636 19778 63152451
Acne 14.04 9.87 64 316729 23229 63149000
Retroperitoneal haemorrhage 14.02 9.87 38 316755 2759 63169470
Pneumothorax spontaneous 14.02 9.87 19 316774 815 63171414
QRS axis abnormal 13.96 9.87 22 316771 1083 63171146
Multiple drug therapy 13.95 9.87 45 316748 3601 63168628
Deformity 13.91 9.87 23 316770 11661 63160568
Blood magnesium decreased 13.87 9.87 113 316680 13085 63159144
Degenerative aortic valve disease 13.86 9.87 9 316784 146 63172083
Ear infection 13.76 9.87 123 316670 38090 63134139
Malignant hypertension 13.76 9.87 23 316770 1190 63171039
Epilepsy 13.69 9.87 79 316714 26986 63145243
Nervousness 13.68 9.87 224 316569 30755 63141474
Epstein-Barr virus infection 13.67 9.87 12 316781 8038 63164191
Head discomfort 13.64 9.87 114 316679 13301 63158928
Peripheral artery stenosis 13.64 9.87 16 316777 592 63171637
Carcinoid tumour 13.61 9.87 13 316780 378 63171851
Jaundice cholestatic 13.59 9.87 10 316783 7314 63164915
Splenic haemorrhage 13.56 9.87 10 316783 201 63172028
Hallucination 13.56 9.87 364 316429 54453 63117776
Personality disorder 13.54 9.87 6 316787 5805 63166424
Macular degeneration 13.52 9.87 69 316724 24307 63147922
Aphthous ulcer 13.50 9.87 31 316762 13907 63158322
Pulmonary tuberculosis 13.49 9.87 3 316790 4514 63167715
Catheterisation cardiac 13.46 9.87 52 316741 4551 63167678
Poor venous access 13.44 9.87 34 316759 14751 63157478
Cardiac discomfort 13.44 9.87 20 316773 936 63171293
Paraesthesia oral 13.43 9.87 50 316743 19206 63153023
Metabolic encephalopathy 13.38 9.87 61 316732 5748 63166481
Cerebral ventricular rupture 13.36 9.87 10 316783 206 63172023
Myalgia 13.34 9.87 875 315918 145654 63026575
Gastrooesophageal reflux disease 13.27 9.87 594 316199 95045 63077184
Unwanted awareness during anaesthesia 13.23 9.87 12 316781 326 63171903
Capillary disorder 13.21 9.87 7 316786 76 63172153
Haemoptysis 13.17 9.87 209 316584 28517 63143712
Adverse drug reaction 13.15 9.87 300 316493 79414 63092815
Ear pain 13.12 9.87 116 316677 36002 63136227
Weight decreased 13.07 9.87 1575 315218 275223 62897006
Retroperitoneal haematoma 13.06 9.87 38 316755 2875 63169354
Blood creatine increased 13.03 9.87 59 316734 5542 63166687
Sciatica 13.02 9.87 109 316684 34215 63138014
Aortic valve disease 13.01 9.87 22 316771 1149 63171080
Renal function test abnormal 13.00 9.87 44 316749 3609 63168620
Hypogammaglobulinaemia 12.98 9.87 10 316783 7145 63165084
Fracture blisters 12.97 9.87 7 316786 79 63172150
Initial insomnia 12.97 9.87 63 316730 6094 63166135
Pharyngitis 12.96 9.87 54 316739 20089 63152140
Tethered cord syndrome 12.96 9.87 11 316782 273 63171956
Tooth disorder 12.96 9.87 205 316588 27952 63144277
Diabetic enteropathy 12.92 9.87 3 316790 0 63172229
Aortic aneurysm repair 12.92 9.87 3 316790 0 63172229
Foetal renal impairment 12.92 9.87 3 316790 0 63172229
Agranulocytosis 12.91 9.87 73 316720 25061 63147168
Peripheral vascular disorder 12.89 9.87 62 316731 5973 63166256
Cyanopsia 12.87 9.87 4 316789 8 63172221
Post-anoxic myoclonus 12.86 9.87 5 316788 24 63172205
Renal vasculitis 12.82 9.87 13 316780 407 63171822
Seroma 12.80 9.87 31 316762 2100 63170129
Vanishing bile duct syndrome 12.80 9.87 17 316776 715 63171514
Mitral valve calcification 12.79 9.87 20 316773 978 63171251
Congenital uterine anomaly 12.75 9.87 8 316785 122 63172107
Aneurysm 12.74 9.87 37 316756 2796 63169433
Gastrointestinal dysplasia 12.68 9.87 6 316787 50 63172179
Pulmonary hypoplasia 12.66 9.87 11 316782 282 63171947
Blood glucose decreased 12.64 9.87 160 316633 20792 63151437
Electrocardiogram QT interval abnormal 12.55 9.87 9 316784 173 63172056
Angiocardiogram 12.48 9.87 6 316787 52 63172177
Device adhesion issue 12.48 9.87 5 316788 5136 63167093
Basal cell carcinoma 12.46 9.87 85 316708 27906 63144323
Subdural haemorrhage 12.40 9.87 39 316754 3079 63169150
Thrombotic microangiopathy 12.38 9.87 21 316772 10540 63161689
Blood electrolytes decreased 12.37 9.87 22 316771 1197 63171032
Nausea 12.36 9.87 4590 312203 849881 62322348
Hypoaldosteronism 12.33 9.87 9 316784 178 63172051
Gastroenteritis clostridial 12.33 9.87 15 316778 577 63171652
Tracheo-oesophageal fistula 12.33 9.87 15 316778 577 63171652
Optic ischaemic neuropathy 12.33 9.87 22 316771 1200 63171029
Gastrointestinal arteriovenous malformation 12.33 9.87 15 316778 577 63171652
Peripheral venous disease 12.28 9.87 38 316755 15439 63156790
Ulcer 12.27 9.87 78 316715 26029 63146200
Antithyroid arthritis syndrome 12.26 9.87 4 316789 10 63172219
Epinephrine increased 12.26 9.87 4 316789 10 63172219
Wound infection pseudomonas 12.25 9.87 23 316770 1305 63170924
Genital labial adhesions 12.23 9.87 5 316788 28 63172201
Blood pressure immeasurable 12.20 9.87 22 316771 1210 63171019
Tricuspid valve incompetence 12.18 9.87 119 316674 14502 63157727
Arthritis 12.17 9.87 464 316329 115457 63056772
Haemorrhagic transformation stroke 12.16 9.87 22 316771 1213 63171016
Demyelination 12.14 9.87 10 316783 6910 63165319
Renal dysplasia 12.13 9.87 10 316783 238 63171991
Coronary artery thrombosis 12.13 9.87 21 316772 1118 63171111
Hyperglycaemia 12.13 9.87 284 316509 41583 63130646
Haemodynamic instability 12.11 9.87 83 316710 9107 63163122
Arterial stent insertion 12.09 9.87 5 316788 29 63172200
Skin tightness 12.01 9.87 48 316745 4268 63167961
Dyschromatopsia 12.00 9.87 13 316780 440 63171789
Complication of device insertion 11.99 9.87 12 316781 7552 63164677
Respiratory tract congestion 11.98 9.87 47 316746 17785 63154444
Intentional underdose 11.98 9.87 28 316765 1854 63170375
Skin necrosis 11.98 9.87 33 316760 13917 63158312
Defaecation disorder 11.94 9.87 17 316776 764 63171465
Coronary artery restenosis 11.93 9.87 12 316781 372 63171857
Amaurosis fugax 11.93 9.87 13 316780 443 63171786
Hospitalisation 11.93 9.87 529 316264 84552 63087677
Neonatal asphyxia 11.92 9.87 11 316782 306 63171923
Device use error 11.86 9.87 7 316786 5754 63166475
Drug use disorder 11.85 9.87 5 316788 4979 63167250
Prescribed underdose 11.85 9.87 93 316700 29596 63142633
Calciphylaxis 11.83 9.87 38 316755 3034 63169195
Hypoperfusion 11.82 9.87 24 316769 1443 63170786
Obstructive airways disorder 11.82 9.87 58 316735 20641 63151588
Postinfarction angina 11.81 9.87 5 316788 31 63172198
Diabetic neuropathy 11.77 9.87 45 316748 3919 63168310
Embolism arterial 11.77 9.87 19 316774 955 63171274
Night sweats 11.74 9.87 172 316621 48642 63123587
Chronic gastritis 11.73 9.87 36 316757 2805 63169424
Injury 11.71 9.87 277 316516 72970 63099259
Depressive symptom 11.71 9.87 3 316790 4099 63168130
Haematemesis 11.66 9.87 215 316578 30197 63142032
Laboratory test abnormal 11.66 9.87 194 316599 26718 63145511
Injection site swelling 11.66 9.87 167 316626 47405 63124824
Facial bones fracture 11.66 9.87 45 316748 3937 63168292
Central nervous system injury 11.65 9.87 8 316785 143 63172086
Optic neuritis 11.61 9.87 15 316778 8420 63163809
Graft versus host disease 11.58 9.87 10 316783 6753 63165476
Intracranial aneurysm 11.56 9.87 43 316750 3696 63168533
Polyhydramnios 11.53 9.87 31 316762 2240 63169989
Hyperparathyroidism 11.50 9.87 35 316758 2714 63169515
Vascular stent stenosis 11.50 9.87 14 316779 539 63171690
Anticoagulation drug level below therapeutic 11.49 9.87 16 316777 704 63171525
Rabbit syndrome 11.48 9.87 11 316782 321 63171908
Brain stem infarction 11.48 9.87 17 316776 792 63171437
Cerebellar haemorrhage 11.46 9.87 23 316770 1371 63170858
Myxoedema 11.43 9.87 7 316786 102 63172127
Gastric cyst 11.43 9.87 7 316786 102 63172127
Extra dose administered 11.31 9.87 62 316731 6288 63165941
Cyanosis neonatal 11.30 9.87 12 316781 397 63171832
Femoral pulse decreased 11.28 9.87 4 316789 14 63172215
Menstruation irregular 11.23 9.87 11 316782 6993 63165236
Gastrointestinal stromal tumour 11.23 9.87 20 316773 1089 63171140
Urinary tract infection bacterial 11.22 9.87 53 316740 5069 63167160
Pulmonary embolism 11.20 9.87 700 316093 115984 63056245
Osmolar gap increased 11.20 9.87 7 316786 106 63172123
Peptic ulcer 11.19 9.87 49 316744 4538 63167691
Arrhythmia supraventricular 11.19 9.87 19 316774 996 63171233
Chemical burn of oral cavity 11.17 9.87 6 316787 67 63172162
Urogenital haemorrhage 11.17 9.87 10 316783 267 63171962
Therapeutic product effect increased 11.15 9.87 21 316772 1194 63171035
Hypotonia 11.15 9.87 82 316711 9203 63163026
Positron emission tomogram abnormal 11.11 9.87 10 316783 269 63171960
Wheezing 11.08 9.87 378 316415 95217 63077012
Blood pressure systolic decreased 11.08 9.87 69 316724 7328 63164901
Full blood count abnormal 11.06 9.87 221 316572 31496 63140733
Dyspnoea at rest 11.06 9.87 45 316748 4034 63168195
Blood creatinine abnormal 11.05 9.87 37 316756 3019 63169210
Hypertransaminasaemia 11.05 9.87 10 316783 6599 63165630
Splenic injury 11.03 9.87 9 316784 211 63172018
Anticoagulation drug level above therapeutic 11 9.87 23 316770 1412 63170817
Coarctation of the aorta 10.98 9.87 14 316779 565 63171664
Serotonin syndrome 10.92 9.87 91 316702 28591 63143638
Ischaemia 10.91 9.87 50 316743 4722 63167507
Pulmonary toxicity 10.90 9.87 19 316774 9436 63162793
Pacemaker syndrome 10.85 9.87 3 316790 3 63172226
Intra-aortic balloon placement 10.85 9.87 3 316790 3 63172226
Rebound tachycardia 10.85 9.87 3 316790 3 63172226
Vaginal oedema 10.85 9.87 3 316790 3 63172226
Carbon dioxide abnormal 10.84 9.87 8 316785 161 63172068
Linear IgA disease 10.83 9.87 23 316770 1428 63170801
Activated partial thromboplastin time prolonged 10.77 9.87 65 316728 6828 63165401
Muscle spasms 10.76 9.87 912 315881 155238 63016991
Palmar-plantar erythrodysaesthesia syndrome 10.69 9.87 69 316724 22946 63149283
Diverticulum 10.69 9.87 99 316694 11892 63160337
Coma 10.68 9.87 242 316551 64122 63108107
Toxic skin eruption 10.68 9.87 31 316762 12854 63159375
Vasoconstriction 10.66 9.87 14 316779 582 63171647
Mesenteric haemorrhage 10.64 9.87 5 316788 41 63172188
Pyuria 10.61 9.87 27 316766 1887 63170342
Non-high-density lipoprotein cholesterol increased 10.59 9.87 8 316785 167 63172062
Aspiration pleural cavity 10.59 9.87 17 316776 850 63171379
Pulmonary thrombosis 10.53 9.87 77 316716 8625 63163604
Food allergy 10.53 9.87 26 316767 11375 63160854
Hypertrophic cardiomyopathy 10.53 9.87 24 316769 1563 63170666
Obesity 10.53 9.87 97 316696 29855 63142374
Product name confusion 10.52 9.87 6 316787 76 63172153
Tongue blistering 10.45 9.87 24 316769 1571 63170658
Urate nephropathy 10.45 9.87 7 316786 120 63172109
Immune reconstitution inflammatory syndrome 10.42 9.87 9 316784 6075 63166154
Anaphylactic shock 10.40 9.87 72 316721 23561 63148668
Embolism venous 10.37 9.87 37 316756 3117 63169112
Hypochromic anaemia 10.36 9.87 27 316766 1915 63170314
Pericardial effusion 10.34 9.87 209 316584 29849 63142380
Visual field defect 10.33 9.87 62 316731 6499 63165730
Peripheral artery thrombosis 10.32 9.87 27 316766 1919 63170310
Lacrimal gland enlargement 10.32 9.87 4 316789 19 63172210
Bronchopulmonary aspergillosis 10.28 9.87 17 316776 8618 63163611
Oral candidiasis 10.26 9.87 69 316724 22729 63149500
Blood glucose abnormal 10.23 9.87 71 316722 7821 63164408
Galactorrhoea 10.15 9.87 4 316789 4151 63168078
Polyglandular autoimmune syndrome type II 10.14 9.87 5 316788 46 63172183
Paradoxical drug reaction 10.14 9.87 4 316789 4148 63168081
Iliac artery occlusion 10.05 9.87 8 316785 181 63172048
Brugada syndrome 10.05 9.87 11 316782 377 63171852
Respiratory alkalosis 10.03 9.87 33 316760 2668 63169561
Uterine perforation 9.99 9.87 12 316781 6951 63165278
Renal aplasia 9.94 9.87 10 316783 310 63171919
Body mass index abnormal 9.94 9.87 6 316787 85 63172144
Diet noncompliance 9.93 9.87 11 316782 382 63171847
Blood creatine phosphokinase MB increased 9.92 9.87 20 316773 1196 63171033
Carotid artery disease 9.92 9.87 24 316769 1625 63170604
Glycosylated haemoglobin increased 9.89 9.87 100 316693 12298 63159931
Haemorrhagic erosive gastritis 9.88 9.87 12 316781 461 63171768
Implantable defibrillator insertion 9.88 9.87 12 316781 461 63171768
Neonatal anuria 9.87 9.87 5 316788 49 63172180

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1286.51 10.92 2889 270609 118196 34565237
Cardiac failure congestive 707.86 10.92 1824 271674 81446 34601987
Coronary artery disease 632.97 10.92 1257 272241 47048 34636385
Bradycardia 563.15 10.92 1575 271923 73843 34609590
Atrial fibrillation 551.58 10.92 2153 271345 120240 34563193
Off label use 432.84 10.92 1755 271743 417769 34265664
Acute myocardial infarction 366.06 10.92 1086 272412 52633 34630800
Drug abuse 351.07 10.92 168 273330 98928 34584505
Hypotension 333.54 10.92 2911 270587 218738 34464695
Coronary artery bypass 333.13 10.92 289 273209 4613 34678820
Dizziness 310.78 10.92 2835 270663 215686 34467747
Syncope 293.52 10.92 1454 272044 89997 34593436
Drug ineffective 256.42 10.92 2315 271183 454436 34228997
Product prescribing error 225.97 10.92 532 272966 22395 34661038
Febrile neutropenia 215.21 10.92 469 273029 136380 34547053
Dyspnoea 204.94 10.92 4106 269392 372676 34310757
Cerebrovascular accident 188.94 10.92 1223 272275 83588 34599845
Coronary arterial stent insertion 187.92 10.92 195 273303 3934 34679499
Neutropenia 178.17 10.92 629 272869 156149 34527284
BRASH syndrome 173.49 10.92 85 273413 461 34682972
Angina unstable 160.65 10.92 310 273188 11343 34672090
Completed suicide 135.71 10.92 1267 272231 96901 34586532
Angina pectoris 135.44 10.92 545 272953 30818 34652615
Drug reaction with eosinophilia and systemic symptoms 134.73 10.92 45 273453 32967 34650466
Pyrexia 132.91 10.92 1822 271676 331191 34352242
Fall 118.23 10.92 2236 271262 200649 34482784
Cardiac disorder 117.74 10.92 656 272842 42470 34640963
Product use in unapproved indication 113.90 10.92 502 272996 116997 34566436
Chest pain 112.01 10.92 1498 272000 125264 34558169
Asthenia 110.48 10.92 2603 270895 242648 34440785
Hepatic function abnormal 109.65 10.92 111 273387 44252 34639181
Hypertensive emergency 104.20 10.92 77 273421 963 34682470
Treatment failure 96.04 10.92 135 273363 46562 34636871
Suspected suicide 93.75 10.92 148 273350 4600 34678833
Atrial flutter 93.11 10.92 301 273197 15273 34668160
Interstitial lung disease 89.63 10.92 240 273258 65042 34618391
Mucosal inflammation 89.47 10.92 102 273396 38520 34644913
Vascular graft 88.14 10.92 82 273416 1440 34681993
Hepatic cytolysis 86.94 10.92 7 273491 14489 34668944
General physical health deterioration 84.97 10.92 1443 272055 126826 34556607
Coronary artery occlusion 84.67 10.92 232 273266 10730 34672703
Arrhythmia 80.02 10.92 517 272981 35291 34648142
Therapeutic product effect incomplete 79.50 10.92 173 273325 50368 34633065
Drug resistance 78.76 10.92 53 273445 25874 34657559
Eosinophilia 76.49 10.92 56 273442 26166 34657267
Sinus bradycardia 76.11 10.92 249 273249 12714 34670719
Fatigue 75.43 10.92 3582 269916 367071 34316362
Ventricular tachycardia 75.00 10.92 408 273090 26171 34657262
International normalised ratio increased 74.16 10.92 628 272870 46699 34636734
Haematochezia 73.73 10.92 619 272879 45915 34637518
Product monitoring error 73.63 10.92 127 273371 4254 34679179
Neutrophil count decreased 70.81 10.92 187 273311 50917 34632516
Gastrointestinal haemorrhage 67.82 10.92 1020 272478 87457 34595976
Acute coronary syndrome 67.18 10.92 246 273252 13299 34670134
Ejection fraction decreased 66.70 10.92 312 273186 18842 34664591
Lower respiratory tract infection 64.51 10.92 92 273406 31545 34651888
Septic shock 61.90 10.92 320 273178 71514 34611919
Infusion related reaction 58.73 10.92 215 273283 52842 34630591
Bronchopulmonary aspergillosis 58.05 10.92 21 273477 14638 34668795
Cardiac arrest 57.65 10.92 1065 272433 95094 34588339
Dehydration 57.59 10.92 1377 272121 128592 34554841
Drug dependence 57.13 10.92 63 273435 24154 34659279
Coronary artery stenosis 56.71 10.92 185 273313 9431 34674002
Myelosuppression 56.37 10.92 41 273457 19224 34664209
Myocardial ischaemia 55.88 10.92 277 273221 17131 34666302
Rash maculo-papular 55.80 10.92 85 273413 28366 34655067
Intentional product use issue 54.66 10.92 261 273237 59555 34623878
Cytomegalovirus infection 54.29 10.92 75 273423 26060 34657373
Product use issue 54.24 10.92 282 273216 62934 34620499
Bone marrow failure 53.98 10.92 91 273407 29162 34654271
Pathogen resistance 53.11 10.92 6 273492 9476 34673957
Pneumocystis jirovecii pneumonia 52.59 10.92 46 273452 19664 34663769
Sopor 52.28 10.92 15 273483 12121 34671312
Hepatocellular injury 52.16 10.92 58 273440 22153 34661280
Toxic epidermal necrolysis 51.41 10.92 56 273442 21590 34661843
Synovitis 51.06 10.92 23 273475 14043 34669390
Acute lung injury 50.96 10.92 61 273437 1449 34681984
Immune reconstitution inflammatory syndrome 50.45 10.92 5 273493 8754 34674679
Nodal arrhythmia 50.26 10.92 47 273451 831 34682602
Asthma 49.11 10.92 170 273328 42486 34640947
Suicidal ideation 48.52 10.92 158 273340 40230 34643203
Oedema peripheral 48.19 10.92 1253 272245 118559 34564874
Rhabdomyolysis 47.71 10.92 774 272724 67389 34616044
Lymphopenia 47.49 10.92 35 273463 16300 34667133
Palpitations 47.36 10.92 500 272998 39486 34643947
Thrombocytopenia 47.35 10.92 899 272599 155348 34528085
Device interaction 47.18 10.92 38 273460 544 34682889
Injury 47.02 10.92 300 273198 20387 34663046
Haematotoxicity 46.36 10.92 5 273493 8189 34675244
Seizure 46.30 10.92 561 272937 104296 34579137
Renal injury 45.52 10.92 191 273307 11004 34672429
Aggression 45.05 10.92 155 273343 38809 34644624
Atrioventricular block 44.77 10.92 152 273346 7911 34675522
C-reactive protein increased 44.37 10.92 245 273253 53853 34629580
Rheumatoid arthritis 44.29 10.92 152 273346 38086 34645347
Obstructive airways disorder 44.01 10.92 34 273464 15460 34667973
Liver disorder 44.00 10.92 123 273375 32874 34650559
Agitation 43.31 10.92 267 273231 57132 34626301
Haemophagocytic lymphohistiocytosis 42.90 10.92 24 273474 12949 34670484
Appendicitis 42.69 10.92 32 273466 14775 34668658
Atrioventricular block complete 42.68 10.92 165 273333 9154 34674279
Dyspnoea exertional 41.74 10.92 520 272978 42759 34640674
Malignant neoplasm progression 41.60 10.92 464 273034 87582 34595851
Toxic skin eruption 40.73 10.92 19 273479 11366 34672067
Anhedonia 40.38 10.92 141 273357 7444 34675989
Aspergillus infection 40.05 10.92 23 273475 12231 34671202
Cardiac failure chronic 39.83 10.92 144 273354 7735 34675698
Haematoma 39.17 10.92 338 273160 25267 34658166
Agranulocytosis 38.74 10.92 80 273418 23741 34659692
Anaphylactic reaction 38.36 10.92 127 273371 32174 34651259
Ascites 38.14 10.92 211 273287 46360 34637073
Transient ischaemic attack 37.89 10.92 356 273142 27257 34656176
Pancytopenia 37.26 10.92 522 272976 94635 34588798
C-reactive protein abnormal 37.09 10.92 11 273487 8699 34674734
Overdose 36.91 10.92 496 273002 90563 34592870
Disseminated intravascular coagulation 36.56 10.92 72 273426 21744 34661689
Infective pulmonary exacerbation of cystic fibrosis 36.39 10.92 5 273493 6796 34676637
Unevaluable event 36.04 10.92 402 273096 32188 34651245
Irritability 36.00 10.92 88 273410 24602 34658831
Substance abuse 35.70 10.92 8 273490 7633 34675800
Cholestasis 35.53 10.92 101 273397 26847 34656586
Drug hypersensitivity 35.48 10.92 431 273067 80098 34603335
Fear 35.27 10.92 169 273329 10307 34673126
Disease progression 35.18 10.92 614 272884 107463 34575970
Prostate cancer 35.06 10.92 175 273323 39474 34643959
Blood loss anaemia 35.05 10.92 142 273356 8052 34675381
Multiple organ dysfunction syndrome 34.80 10.92 407 273091 76159 34607274
Hyperthermia 34.36 10.92 20 273478 10557 34672876
Acute graft versus host disease 34.28 10.92 5 273493 6498 34676935
Haemorrhage intracranial 34.25 10.92 228 273270 15718 34667715
Orthostatic hypotension 34.00 10.92 331 273167 25588 34657845
Cytokine release syndrome 33.78 10.92 81 273417 22796 34660637
Abdominal pain lower 33.78 10.92 168 273330 10403 34673030
Mitral valve incompetence 33.52 10.92 216 273282 14727 34668706
Wound 33.43 10.92 215 273283 14649 34668784
Renal failure 33.16 10.92 1292 272206 129265 34554168
Troponin increased 32.92 10.92 176 273322 11213 34672220
Progressive multifocal leukoencephalopathy 32.38 10.92 18 273480 9746 34673687
Respiratory depression 32.37 10.92 48 273450 16197 34667236
Suicide attempt 32.15 10.92 177 273321 38939 34644494
Mitral valve disease 31.93 10.92 47 273451 1372 34682061
Sinus node dysfunction 31.89 10.92 89 273409 4160 34679273
Abnormal behaviour 31.88 10.92 95 273403 24874 34658559
Atrial thrombosis 31.87 10.92 60 273438 2154 34681279
Urticaria 31.36 10.92 324 273174 62053 34621380
Extrapyramidal disorder 30.94 10.92 33 273465 12847 34670586
Exercise tolerance decreased 30.65 10.92 100 273398 5098 34678335
Hyperkalaemia 30.64 10.92 735 272763 68654 34614779
Venoocclusive liver disease 30.56 10.92 12 273486 7954 34675479
Presyncope 30.42 10.92 254 273244 18805 34664628
Blood creatinine increased 30.35 10.92 965 272533 94011 34589422
Alanine aminotransferase increased 30.34 10.92 447 273051 80368 34603065
Multiple-drug resistance 30.15 10.92 3 273495 5236 34678197
Therapy partial responder 30.09 10.92 19 273479 9597 34673836
Aortic stenosis 29.54 10.92 88 273410 4270 34679163
Neuroleptic malignant syndrome 29.35 10.92 60 273438 17874 34665559
Cytomegalovirus infection reactivation 29.27 10.92 3 273495 5115 34678318
Pacemaker generated rhythm 28.72 10.92 13 273485 57 34683376
Catatonia 28.60 10.92 3 273495 5022 34678411
Malaise 28.57 10.92 1176 272322 184649 34498784
Respiratory distress 28.43 10.92 163 273335 35502 34647931
Colitis 28.27 10.92 176 273322 37574 34645859
Labelled drug-drug interaction medication error 28.21 10.92 207 273291 14732 34668701
Therapeutic drug monitoring analysis not performed 28.11 10.92 28 273470 537 34682896
Arteriosclerosis 28.09 10.92 175 273323 11793 34671640
Acute generalised exanthematous pustulosis 28.06 10.92 9 273489 6767 34676666
Myxoedema coma 28.00 10.92 21 273477 269 34683164
Hyponatraemia 27.80 10.92 467 273031 82224 34601209
Migraine 27.33 10.92 60 273438 17418 34666015
Heart rate increased 27.30 10.92 512 272986 45831 34637602
Anaphylactic shock 27.24 10.92 52 273446 15889 34667544
Chronotropic incompetence 27.19 10.92 9 273489 12 34683421
Stomatitis 27.00 10.92 208 273290 42306 34641127
Supraventricular tachycardia 27 10.92 164 273334 10953 34672480
Condition aggravated 26.92 10.92 1229 272269 190967 34492466
Epstein-Barr virus infection 26.87 10.92 13 273485 7615 34675818
Circulatory collapse 26.78 10.92 267 273231 20771 34662662
Sedation 26.76 10.92 80 273418 20926 34662507
Altered state of consciousness 26.51 10.92 91 273407 22802 34660631
Coma 26.49 10.92 229 273269 45449 34637984
Shone complex 26.31 10.92 13 273485 72 34683361
Blood glucose increased 26.29 10.92 696 272802 66022 34617411
Cardiac operation 26.26 10.92 68 273430 3039 34680394
Psychomotor hyperactivity 26.22 10.92 22 273476 9600 34673833
Systemic infection 26.13 10.92 95 273403 5117 34678316
Sinus arrest 26.10 10.92 48 273450 1692 34681741
Blood pressure increased 26.05 10.92 887 272611 87215 34596218
Ventricular extrasystoles 25.98 10.92 172 273326 11836 34671597
Gout 25.80 10.92 247 273251 19006 34664427
Graft versus host disease 25.48 10.92 27 273471 10542 34672891
Peripheral vascular disorder 25.42 10.92 92 273406 4944 34678489
Status epilepticus 25.40 10.92 37 273461 12577 34670856
Heart rate decreased 24.69 10.92 367 273131 31378 34652055
Erythema multiforme 24.54 10.92 19 273479 8630 34674803
Aplastic anaemia 24.35 10.92 24 273474 9692 34673741
Cardiac valve disease 24.09 10.92 66 273432 3052 34680381
Chronic graft versus host disease 23.91 10.92 3 273495 4370 34679063
Muscle necrosis 23.88 10.92 32 273466 854 34682579
Hyperbilirubinaemia 23.80 10.92 61 273437 16782 34666651
Intentional product misuse 23.71 10.92 235 273263 45376 34638057
Bronchiectasis 23.67 10.92 25 273473 9776 34673657
Cerebral haemorrhage 23.43 10.92 394 273104 34543 34648890
Hyperlipidaemia 23.38 10.92 194 273304 14335 34669098
Carcinoma in situ of skin 23.38 10.92 12 273486 73 34683360
Blood urine present 23.32 10.92 155 273343 10679 34672754
Headache 23.27 10.92 1308 272190 199327 34484106
Epilepsy 23.19 10.92 88 273410 21407 34662026
Tumour lysis syndrome 23.18 10.92 63 273435 16996 34666437
Somnolence 23.12 10.92 677 272821 110439 34572994
Coronary angioplasty 23.12 10.92 22 273476 398 34683035
Arteriosclerosis coronary artery 23.01 10.92 172 273326 12313 34671120
Low cardiac output syndrome 22.92 10.92 26 273472 582 34682851
Cardiac failure 22.91 10.92 902 272596 90346 34593087
Sepsis 22.72 10.92 1068 272430 165493 34517940
Fracture 22.70 10.92 110 273388 6739 34676694
Pericardial haemorrhage 22.58 10.92 65 273433 3093 34680340
Chronic kidney disease 22.48 10.92 450 273048 40760 34642673
Exposure during pregnancy 22.47 10.92 22 273476 8912 34674521
Drug eruption 22.43 10.92 80 273418 19818 34663615
Coagulopathy 22.29 10.92 245 273253 19544 34663889
Aorta hypoplasia 22.24 10.92 12 273486 82 34683351
Pancreatitis acute 22.22 10.92 129 273369 28012 34655421
Uveitis 22.09 10.92 16 273482 7519 34675914
Obsessive-compulsive disorder 21.98 10.92 8 273490 5556 34677877
Mental status changes 21.83 10.92 419 273079 37664 34645769
Nephrogenic systemic fibrosis 21.80 10.92 75 273423 3930 34679503
Aspartate aminotransferase increased 21.75 10.92 386 273112 67397 34616036
Pneumonia aspiration 21.32 10.92 217 273281 41686 34641747
Heart rate irregular 21.29 10.92 203 273295 15604 34667829
Therapeutic product effect decreased 21.13 10.92 172 273326 34571 34648862
Vomiting 21.02 10.92 1660 271838 245961 34437472
Hyperthyroidism 20.87 10.92 148 273350 10418 34673015
Incorrect route of product administration 20.80 10.92 54 273444 14791 34668642
Leukopenia 20.79 10.92 356 273142 62500 34620933
Hypogammaglobulinaemia 20.72 10.92 18 273480 7722 34675711
Upper gastrointestinal haemorrhage 20.63 10.92 297 273201 25221 34658212
Tuberculosis 20.57 10.92 22 273476 8555 34674878
Cardiovascular disorder 20.53 10.92 142 273356 9914 34673519
Blood pressure inadequately controlled 20.51 10.92 56 273442 2584 34680849
Hepatitis B reactivation 20.49 10.92 3 273495 3888 34679545
Haemoglobin decreased 20.49 10.92 1148 272350 119624 34563809
Intracardiac thrombus 20.46 10.92 54 273444 2442 34680991
Infection 20.42 10.92 548 272950 90367 34593066
Left atrial enlargement 20.40 10.92 30 273468 875 34682558
Lymphoma 20.34 10.92 42 273456 12465 34670968
Atrioventricular block first degree 20.31 10.92 98 273400 5994 34677439
Bundle branch block right 20.28 10.92 114 273384 7402 34676031
Erythema 20.24 10.92 534 272964 88246 34595187
Mouth ulceration 20.22 10.92 39 273459 11871 34671562
Nocturia 20.16 10.92 143 273355 10067 34673366
Blood pressure abnormal 19.95 10.92 120 273378 7986 34675447
Hypertriglyceridaemia 19.90 10.92 22 273476 8426 34675007
Hepatitis B 19.88 10.92 11 273487 5972 34677461
Basal ganglia haemorrhage 19.87 10.92 30 273468 896 34682537
Drug intolerance 19.83 10.92 337 273161 59233 34624200
Acute graft versus host disease in skin 19.68 10.92 8 273490 5193 34678240
Cytopenia 19.63 10.92 44 273454 12679 34670754
Psoriatic arthropathy 19.50 10.92 84 273414 19714 34663719
Contusion 19.47 10.92 396 273102 35968 34647465
Anastomotic infection 19.42 10.92 12 273486 109 34683324
Stent placement 19.38 10.92 85 273413 4993 34678440
Chest discomfort 19.27 10.92 561 272937 53969 34629464
Tachyarrhythmia 19.14 10.92 67 273431 3541 34679892
Intestinal atony 19.05 10.92 8 273490 28 34683405
Internal haemorrhage 18.95 10.92 84 273414 4957 34678476
Joint swelling 18.91 10.92 342 273156 59548 34623885
Tricuspid valve incompetence 18.86 10.92 136 273362 9624 34673809
Supravalvular aortic stenosis 18.80 10.92 9 273489 46 34683387
Emotional distress 18.78 10.92 190 273308 14836 34668597
Rash 18.78 10.92 1494 272004 221258 34462175
Hypertensive crisis 18.72 10.92 125 273373 8626 34674807
Increased tendency to bruise 18.68 10.92 72 273426 3989 34679444
Upper motor neurone lesion 18.63 10.92 12 273486 118 34683315
Neutropenic sepsis 18.59 10.92 51 273447 13716 34669717
Drug-disease interaction 18.58 10.92 21 273477 468 34682965
Colorectal cancer 18.55 10.92 7 273491 4754 34678679
Inspiratory capacity abnormal 18.47 10.92 12 273486 120 34683313
Hepatocellular carcinoma 18.30 10.92 19 273479 7490 34675943
Ventricular hypokinesia 18.28 10.92 89 273409 5463 34677970
Glomerular filtration rate decreased 18.23 10.92 168 273330 12793 34670640
Drug ineffective for unapproved indication 18.05 10.92 110 273388 23605 34659828
Secretion discharge 18.03 10.92 12 273486 5893 34677540
Arthralgia 18.02 10.92 1118 272380 168923 34514510
Non-cardiac chest pain 18.01 10.92 74 273424 4223 34679210
Fluid retention 17.94 10.92 303 273195 26584 34656849
Oesophageal obstruction 17.93 10.92 21 273477 487 34682946
Plasma cell myeloma 17.86 10.92 443 273055 41594 34641839
Drug withdrawal syndrome 17.84 10.92 87 273411 19747 34663686
Nodular rash 17.80 10.92 11 273487 100 34683333
Autoimmune myositis 17.67 10.92 12 273486 130 34683303
Neuropathy peripheral 17.64 10.92 506 272992 82757 34600676
Diffuse large B-cell lymphoma 17.57 10.92 19 273479 7351 34676082
Heart rate abnormal 17.50 10.92 42 273456 1789 34681644
Dysgeusia 17.46 10.92 298 273200 26199 34657234
Iliac artery stenosis 17.34 10.92 10 273488 79 34683354
Blood glucose decreased 17.33 10.92 169 273329 13068 34670365
Immune thrombocytopenia 17.32 10.92 28 273470 9124 34674309
Macrophages increased 17.30 10.92 13 273485 167 34683266
Large for dates baby 17.28 10.92 28 273470 890 34682543
Product residue present 17.26 10.92 54 273444 2692 34680741
Mitral valve hypoplasia 17.17 10.92 8 273490 38 34683395
Diabetic foetopathy 17.12 10.92 14 273484 205 34683228
Ventricular arrhythmia 17.06 10.92 87 273411 5441 34677992
Nodal rhythm 17.04 10.92 36 273462 1407 34682026
Thrombotic microangiopathy 17.03 10.92 36 273462 10594 34672839
Extrasystoles 16.95 10.92 67 273431 3756 34679677
Pulmonary tuberculosis 16.90 10.92 8 273490 4746 34678687
Cardioversion 16.90 10.92 28 273470 907 34682526
Full blood count decreased 16.86 10.92 216 273282 17872 34665561
Drug abuser 16.82 10.92 5 273493 3949 34679484
Nocardiosis 16.81 10.92 5 273493 3946 34679487
Leukoencephalopathy 16.75 10.92 6 273492 4209 34679224
Neoplasm progression 16.74 10.92 110 273388 23190 34660243
Foetal exposure during pregnancy 16.74 10.92 204 273294 37897 34645536
Orthostatic intolerance 16.73 10.92 26 273472 797 34682636
Osteonecrosis 16.69 10.92 60 273438 14830 34668603
Low density lipoprotein abnormal 16.66 10.92 17 273481 336 34683097
Hepatitis 16.60 10.92 114 273384 23790 34659643
Hypoalbuminaemia 16.51 10.92 45 273453 12129 34671304
Occult blood positive 16.40 10.92 69 273429 3979 34679454
Miosis 16.38 10.92 31 273467 9504 34673929
Autoimmune myocarditis 16.26 10.92 14 273484 221 34683212
Sinusitis 16.23 10.92 227 273271 41175 34642258
Type IIa hyperlipidaemia 16.20 10.92 13 273485 185 34683248
Oesophageal carcinoma 16.20 10.92 30 273468 9274 34674159
Akathisia 16.12 10.92 24 273474 8085 34675348
Torsade de pointes 16.04 10.92 104 273394 7105 34676328
Vascular stent thrombosis 16.01 10.92 55 273443 2880 34680553
Lung disorder 15.92 10.92 184 273314 34512 34648921
Left ventricular failure 15.90 10.92 81 273417 5063 34678370
Poisoning deliberate 15.80 10.92 23 273475 7821 34675612
Peripheral arterial occlusive disease 15.78 10.92 89 273409 5785 34677648
Intentional self-injury 15.77 10.92 55 273443 13716 34669717
End stage renal disease 15.72 10.92 121 273377 8740 34674693
Urinary tract obstruction 15.69 10.92 63 273435 3557 34679876
Essential hypertension 15.66 10.92 56 273442 2992 34680441
Dizziness postural 15.65 10.92 92 273406 6072 34677361
Neurotoxicity 15.63 10.92 80 273418 17930 34665503
Mitral valve prolapse 15.62 10.92 22 273476 616 34682817
Left ventricle outflow tract obstruction 15.54 10.92 12 273486 161 34683272
Musculoskeletal pain 15.47 10.92 343 273155 31620 34651813
Cystitis haemorrhagic 15.46 10.92 13 273485 5666 34677767
Electrocardiogram RR interval prolonged 15.43 10.92 4 273494 0 34683433
Kidney rupture 15.43 10.92 13 273485 199 34683234
Blood potassium increased 15.39 10.92 197 273301 16298 34667135
Dysmorphism 15.37 10.92 3 273495 3153 34680280
Catheterisation cardiac 15.33 10.92 51 273447 2626 34680807
Euphoric mood 15.25 10.92 13 273485 5628 34677805
Parathyroid hormone-related protein abnormal 15.22 10.92 6 273492 17 34683416
Anal fistula 15.14 10.92 12 273486 5387 34678046
Chromaturia 15.10 10.92 177 273321 14343 34669090
Lower gastrointestinal haemorrhage 15.10 10.92 126 273372 9326 34674107
Gastric cancer 15.07 10.92 17 273481 6452 34676981
Graft versus host disease in gastrointestinal tract 15.06 10.92 5 273493 3678 34679755
Central nervous system lesion 15.04 10.92 17 273481 6446 34676987
High density lipoprotein decreased 14.99 10.92 59 273439 3301 34680132
Pulmonary renal syndrome 14.94 10.92 12 273486 171 34683262
Graft versus host disease in skin 14.91 10.92 6 273492 3919 34679514
Atrioventricular block second degree 14.91 10.92 64 273434 3724 34679709
Congenital heart valve disorder 14.91 10.92 8 273490 54 34683379
Therapeutic response decreased 14.83 10.92 152 273346 29161 34654272
Exposure via ingestion 14.74 10.92 44 273454 2137 34681296
Drug withdrawal syndrome neonatal 14.65 10.92 5 273493 3614 34679819
No adverse event 14.64 10.92 112 273386 22815 34660618
Penis injury 14.63 10.92 14 273484 255 34683178
Therapeutic response shortened 14.63 10.92 22 273476 7382 34676051
Post procedural haemorrhage 14.60 10.92 113 273385 8176 34675257
Face oedema 14.57 10.92 44 273454 11472 34671961
Diverticulum 14.56 10.92 101 273397 7058 34676375
Cornea verticillata 14.55 10.92 8 273490 57 34683376
Antiacetylcholine receptor antibody positive 14.55 10.92 8 273490 57 34683376
Cytomegalovirus chorioretinitis 14.45 10.92 5 273493 3584 34679849
Aplasia 14.45 10.92 9 273489 4579 34678854
Psychotic disorder 14.43 10.92 122 273376 24330 34659103
Haemodilution 14.43 10.92 7 273491 37 34683396
Cardiovascular insufficiency 14.34 10.92 37 273461 1650 34681783
Neonatal respiratory failure 14.32 10.92 16 273482 352 34683081
Post transplant lymphoproliferative disorder 14.30 10.92 18 273480 6510 34676923
Medication error 14.22 10.92 280 273218 25285 34658148
Inferior vena cava syndrome 14.22 10.92 8 273490 60 34683373
Spinal epidural haemorrhage 14.14 10.92 7 273491 39 34683394
Bacterial infection 14.13 10.92 77 273421 16986 34666447
Priapism 14.13 10.92 11 273487 4983 34678450
Oral candidiasis 14.11 10.92 48 273450 12062 34671371
Dyskinesia 14.07 10.92 110 273388 22303 34661130
Loss of personal independence in daily activities 14.06 10.92 179 273319 33000 34650433
Postural orthostatic tachycardia syndrome 14.02 10.92 9 273489 88 34683345
Penile haemorrhage 13.94 10.92 21 273477 626 34682807
Arterial occlusive disease 13.93 10.92 69 273429 4265 34679168
Bone erosion 13.91 10.92 7 273491 4008 34679425
Portal fibrosis 13.86 10.92 15 273483 318 34683115
Coma scale abnormal 13.86 10.92 7 273491 4001 34679432
Electrocardiogram PR prolongation 13.82 10.92 25 273473 870 34682563
Pseudomonas infection 13.81 10.92 50 273448 12332 34671101
Biopsy lymph gland 13.69 10.92 8 273490 65 34683368
Gastrointestinal tract mucosal pigmentation 13.67 10.92 18 273480 472 34682961
Systemic candida 13.67 10.92 6 273492 3720 34679713
Haemorrhage 13.64 10.92 511 272987 50859 34632574
Herpes simplex 13.63 10.92 14 273484 5545 34677888
Implantable defibrillator insertion 13.51 10.92 23 273475 762 34682671
Ischaemic cardiomyopathy 13.51 10.92 91 273407 6298 34677135
Orthopnoea 13.50 10.92 77 273421 5026 34678407
Balance disorder 13.48 10.92 415 273083 40239 34643194
Blood lactate dehydrogenase increased 13.44 10.92 115 273383 22875 34660558
Gamma-glutamyltransferase increased 13.42 10.92 155 273343 29076 34654357
Venoocclusive disease 13.40 10.92 3 273495 2864 34680569
Blood pressure orthostatic 13.39 10.92 8 273490 68 34683365
Stevens-Johnson syndrome 13.39 10.92 88 273410 18551 34664882
Blood pressure decreased 13.34 10.92 511 272987 51004 34632429
Precancerous skin lesion 13.33 10.92 20 273478 594 34682839
Diverticulum intestinal haemorrhagic 13.31 10.92 47 273451 2495 34680938
Haematuria 13.29 10.92 498 273000 49568 34633865
Psychomotor skills impaired 13.25 10.92 7 273491 3899 34679534
Faeces pale 13.22 10.92 32 273466 1371 34682062
Acoustic stimulation tests abnormal 13.20 10.92 8 273490 70 34683363
Pallor 13.15 10.92 276 273222 25204 34658229
Apallic syndrome 13.15 10.92 13 273485 247 34683186
Pulmonary fibrosis 13.14 10.92 87 273411 18309 34665124
Immune-mediated myositis 13.12 10.92 41 273457 2042 34681391
Vestibular neuronitis 13.12 10.92 12 273486 206 34683227
Arteriosclerotic gangrene 13.10 10.92 8 273490 71 34683362
Pulseless electrical activity 13.09 10.92 99 273399 7112 34676321
Duodenal ulcer 13.08 10.92 131 273367 10201 34673232
Pulmonary valve stenosis congenital 13.08 10.92 10 273488 132 34683301
Conjunctivitis 13.07 10.92 36 273462 9669 34673764
Gait disturbance 13.04 10.92 802 272696 84338 34599095
Aortic valve incompetence 13.03 10.92 85 273413 5819 34677614
Tenosynovitis 13.02 10.92 10 273488 4560 34678873
Increased viscosity of bronchial secretion 12.93 10.92 12 273486 210 34683223
Cholelithiasis 12.92 10.92 235 273263 20913 34662520
Aphthous ulcer 12.91 10.92 12 273486 4983 34678450
Cytomegalovirus viraemia 12.90 10.92 24 273474 7406 34676027
Tongue discomfort 12.87 10.92 20 273478 613 34682820
Product solubility abnormal 12.86 10.92 18 273480 501 34682932
Asphyxia 12.85 10.92 21 273477 6814 34676619
Aortic aneurysm 12.84 10.92 94 273404 6685 34676748
Generalised tonic-clonic seizure 12.79 10.92 105 273393 21069 34662364
Nodule 12.77 10.92 21 273477 6798 34676635
Varicose vein 12.75 10.92 31 273467 1332 34682101
Sickle cell anaemia with crisis 12.69 10.92 8 273490 4045 34679388
Parkinsonism 12.67 10.92 28 273470 8110 34675323
Hypovolaemia 12.64 10.92 119 273379 9115 34674318
Posterior reversible encephalopathy syndrome 12.61 10.92 38 273460 9916 34673517
Acute lymphocytic leukaemia 12.58 10.92 4 273494 3025 34680408
Infantile apnoea 12.56 10.92 25 273473 936 34682497
Pulse pressure decreased 12.50 10.92 11 273487 179 34683254
Alcohol abuse 12.44 10.92 11 273487 4679 34678754
Vascular access site occlusion 12.39 10.92 7 273491 53 34683380
Retching 12.38 10.92 93 273405 6668 34676765
Blue toe syndrome 12.37 10.92 10 273488 144 34683289
Cardiogenic shock 12.37 10.92 284 273214 26334 34657099
Faeces discoloured 12.36 10.92 174 273324 14704 34668729
Heart valve incompetence 12.33 10.92 32 273466 1432 34682001
Thoracic haemorrhage 12.31 10.92 11 273487 183 34683250
Toxicity to various agents 12.29 10.92 1376 272122 198986 34484447
Ageusia 12.25 10.92 129 273369 10179 34673254
Neonatal tachycardia 12.24 10.92 5 273493 16 34683417
Hepatojugular reflux 12.24 10.92 19 273479 582 34682851
Cardiac function test abnormal 12.18 10.92 6 273492 33 34683400
Withdrawal syndrome 12.17 10.92 53 273445 12402 34671031
Mucosal haemorrhage 12.16 10.92 34 273464 1591 34681842
International normalised ratio decreased 12.14 10.92 69 273429 4498 34678935
Jaundice 12.07 10.92 176 273322 31706 34651727
Device related infection 12.07 10.92 82 273416 17155 34666278
COVID-19 12.05 10.92 490 273008 77060 34606373
Rheumatoid nodule 12.05 10.92 4 273494 2943 34680490
Hepatosplenomegaly 12.03 10.92 9 273489 4160 34679273
Ulcer haemorrhage 12.00 10.92 47 273451 2623 34680810
Blood bilirubin increased 11.99 10.92 219 273279 38077 34645356
Withdrawal hypertension 11.97 10.92 11 273487 190 34683243
Hepatitis acute 11.96 10.92 26 273472 7575 34675858
Ischaemic stroke 11.93 10.92 205 273293 18045 34665388
Bradyarrhythmia 11.90 10.92 41 273457 2150 34681283
Cardiovascular somatic symptom disorder 11.89 10.92 6 273492 35 34683398
Idiopathic pulmonary fibrosis 11.89 10.92 57 273441 3477 34679956
Alcohol interaction 11.83 10.92 4 273494 2909 34680524
Facial asymmetry 11.81 10.92 14 273484 329 34683104
Hyperferritinaemia 11.80 10.92 16 273482 432 34683001
Bacterial parotitis 11.76 10.92 6 273492 36 34683397
Lymphomatoid papulosis 11.74 10.92 11 273487 195 34683238
Blood phosphorus increased 11.67 10.92 27 273471 7694 34675739
White blood cell count decreased 11.64 10.92 619 272879 94826 34588607
Muscle rupture 11.62 10.92 42 273456 2256 34681177
Organising pneumonia 11.59 10.92 18 273480 5961 34677472
Non-small cell lung cancer stage IIIA 11.58 10.92 3 273495 0 34683433
Peroneal nerve injury 11.58 10.92 3 273495 0 34683433
Myofascial spasm 11.58 10.92 3 273495 0 34683433
Venous pressure jugular abnormal 11.58 10.92 3 273495 0 34683433
Cardiovascular symptom 11.58 10.92 3 273495 0 34683433
Urinary sediment 11.58 10.92 3 273495 0 34683433
Paraganglion neoplasm 11.58 10.92 3 273495 0 34683433
Carcinoid tumour of the gastrointestinal tract 11.57 10.92 7 273491 61 34683372
Hyperammonaemia 11.57 10.92 20 273478 6347 34677086
Fungal infection 11.56 10.92 75 273423 15860 34667573
Prostate cancer stage I 11.53 10.92 3 273495 2586 34680847
Intercepted product preparation error 11.52 10.92 9 273489 4069 34679364
Platelet count decreased 11.50 10.92 794 272704 118923 34564510
Anal fissure 11.46 10.92 10 273488 4280 34679153
Cardiac pacemaker insertion 11.44 10.92 49 273449 2849 34680584
Rhinitis 11.43 10.92 20 273478 6318 34677115
Cold sweat 11.41 10.92 124 273374 9863 34673570
Histology abnormal 11.39 10.92 13 273485 293 34683140
Product quality issue 11.38 10.92 192 273306 16843 34666590
Encephalitis 11.36 10.92 25 273473 7252 34676181
Electrolyte imbalance 11.35 10.92 167 273331 14245 34669188
Dystonia 11.31 10.92 45 273453 10800 34672633
Coronary artery restenosis 11.30 10.92 25 273473 1009 34682424
Pyonephrosis 11.29 10.92 7 273491 64 34683369
Alanine aminotransferase abnormal 11.27 10.92 12 273486 4676 34678757
Cardiac flutter 11.24 10.92 36 273462 1817 34681616
Hepatic encephalopathy 11.23 10.92 68 273430 14617 34668816
Patent ductus arteriosus 11.21 10.92 54 273444 3300 34680133
Chronic left ventricular failure 11.18 10.92 18 273480 569 34682864
Mitral valve sclerosis 11.17 10.92 9 273489 129 34683304
Bradycardia neonatal 11.12 10.92 24 273474 952 34682481
Pneumonia cytomegaloviral 11.07 10.92 5 273493 3049 34680384
Peripheral artery occlusion 11.07 10.92 34 273464 1678 34681755
Dermatitis exfoliative 11.04 10.92 22 273476 6617 34676816
Hyperpyrexia 11.03 10.92 4 273494 2784 34680649
Myocardial rupture 10.96 10.92 10 273488 171 34683262
Aortic valve calcification 10.93 10.92 14 273484 357 34683076
Carotid artery stenosis 10.92 10.92 72 273426 4947 34678486

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2597.25 9.92 4263 475935 179866 79084324
Cardiac failure congestive 1534.64 9.92 2932 477266 139470 79124720
Coronary artery disease 1300.85 9.92 1781 478417 63693 79200497
Bradycardia 1251.53 9.92 2617 477581 132940 79131250
Atrial fibrillation 1223.08 9.92 3266 476932 194620 79069570
Acute myocardial infarction 864.90 9.92 1615 478583 75421 79188769
Hypotension 745.66 9.92 4867 475331 435450 78828740
Synovitis 690.90 9.92 58 480140 150676 79113514
Off label use 639.64 9.92 3053 477145 904162 78360028
Completed suicide 621.48 9.92 3027 477171 242740 79021450
Syncope 606.35 9.92 2411 477787 177038 79087152
Drug ineffective 604.14 9.92 3928 476270 1076985 78187205
Product prescribing error 582.92 9.92 1002 479196 43811 79220379
Cerebrovascular accident 530.61 9.92 2094 478104 153198 79110992
Coronary artery bypass 521.26 9.92 369 479829 5693 79258497
Hand deformity 511.15 9.92 28 480170 103891 79160299
Pemphigus 468.41 9.92 34 480164 99548 79164642
Systemic lupus erythematosus 462.23 9.92 85 480113 121064 79143126
Drug intolerance 439.73 9.92 567 479631 263552 79000638
Infusion related reaction 434.37 9.92 447 479751 229790 79034400
Treatment failure 419.88 9.92 253 479945 170233 79093957
Arthropathy 414.04 9.92 279 479919 176832 79087358
Joint swelling 413.67 9.92 688 479510 287958 78976232
Dizziness 411.47 9.92 4910 475288 521531 78742659
Pericarditis 357.40 9.92 93 480105 104143 79160047
Glossodynia 356.61 9.92 91 480107 103246 79160944
Dyspnoea 355.34 9.92 7178 473020 849847 78414343
Lower respiratory tract infection 354.52 9.92 167 480031 129053 79135137
BRASH syndrome 351.98 9.92 155 480043 862 79263328
Rheumatoid factor positive 338.46 9.92 4 480194 59835 79204355
Duodenal ulcer perforation 337.97 9.92 14 480184 66197 79197993
Helicobacter infection 324.38 9.92 25 480173 69679 79194511
Coronary arterial stent insertion 313.56 9.92 273 479925 5771 79258419
Therapeutic product effect decreased 311.39 9.92 316 479882 163547 79100643
Angina unstable 307.73 9.92 436 479762 16091 79248099
Cardiac disorder 301.70 9.92 977 479221 64780 79199410
Rheumatoid arthritis 301.23 9.92 494 479704 207976 79056214
Drug abuse 298.74 9.92 323 479875 162368 79101822
Contraindicated product administered 294.60 9.92 308 479890 157230 79106960
Fall 294.08 9.92 4340 475858 483289 78780901
Hypersensitivity 282.01 9.92 736 479462 261503 79002687
Angina pectoris 281.56 9.92 816 479382 50916 79213274
Gastrointestinal haemorrhage 273.98 9.92 1673 478525 146046 79118144
Suspected suicide 271.73 9.92 327 479871 10249 79253941
Product monitoring error 266.76 9.92 298 479900 8608 79255582
General physical health deterioration 264 9.92 2675 477523 272563 78991627
Folliculitis 257.31 9.92 20 480178 55360 79208830
Muscle injury 235.95 9.92 14 480184 48547 79215643
Sinus bradycardia 226.31 9.92 482 479716 24765 79239425
Haematochezia 218.56 9.92 1076 479122 86569 79177621
Alopecia 214.65 9.92 696 479502 230659 79033531
Pyrexia 212.29 9.92 2847 477351 675862 78588328
Cardiac arrest 210.63 9.92 1763 478435 170333 79093857
International normalised ratio increased 208.34 9.92 1036 479162 83685 79180505
Swelling 205.90 9.92 645 479553 216066 79048124
Maternal exposure during pregnancy 203.34 9.92 317 479881 136221 79127969
Febrile neutropenia 197.34 9.92 720 479478 230279 79033911
Chest pain 195.02 9.92 2575 477623 279729 78984461
Arthralgia 194.50 9.92 2356 477842 569447 78694743
C-reactive protein abnormal 190.88 9.92 31 480167 48336 79215854
Irritable bowel syndrome 190.83 9.92 68 480130 62173 79202017
Asthenia 190.12 9.92 4221 475977 507468 78756722
Dehydration 189.78 9.92 2307 477891 245880 79018310
Product use issue 187.91 9.92 641 479557 209181 79055009
Hepatic enzyme increased 186.82 9.92 525 479673 182085 79082105
Rash 183.28 9.92 2419 477779 575939 78688251
Renal failure 176.90 9.92 1920 478278 199048 79065142
Drug hypersensitivity 176.11 9.92 1066 479132 297850 78966340
Arrhythmia 176.05 9.92 784 479414 60488 79203702
Neutropenia 174.81 9.92 1016 479182 286694 78977496
Ventricular tachycardia 173.64 9.92 602 479596 41333 79222857
Death 173.19 9.92 4550 475648 561964 78702226
Discomfort 165.68 9.92 315 479883 125302 79138888
Drug interaction 163.71 9.92 3455 476743 411728 78852462
Product use in unapproved indication 160.26 9.92 869 479329 249490 79014700
Blister 158.98 9.92 298 479900 119178 79145012
Sleep disorder due to general medical condition, insomnia type 158.87 9.92 34 480164 43522 79220668
Sinusitis 158.74 9.92 622 479576 194879 79069311
Drug reaction with eosinophilia and systemic symptoms 157.15 9.92 96 480102 64148 79200042
Hypertensive emergency 155.07 9.92 131 480067 2654 79261536
Labelled drug-drug interaction medication error 151.25 9.92 437 479761 27213 79236977
Musculoskeletal stiffness 149.74 9.92 545 479653 174463 79089727
Oedema peripheral 146.80 9.92 2233 477965 250055 79014135
Palpitations 144.34 9.92 1277 478921 125333 79138857
Cardiac failure 143.07 9.92 1494 478704 153348 79110842
Cardiogenic shock 141.99 9.92 564 479634 41350 79222840
Atrial flutter 141.47 9.92 365 479833 21260 79242930
Acute coronary syndrome 139.60 9.92 358 479840 20775 79243415
Rhabdomyolysis 137.20 9.92 1077 479121 102054 79162136
C-reactive protein increased 135.63 9.92 366 479832 128661 79135529
Vascular graft 133.00 9.92 105 480093 1926 79262264
Hepatic cytolysis 131.38 9.92 8 480190 27143 79237047
Intentional product use issue 127.29 9.92 478 479720 151634 79112556
Atrioventricular block 124.61 9.92 267 479931 13774 79250416
Hyperkalaemia 124.35 9.92 1142 479056 113256 79150934
Infection 122.71 9.92 901 479297 240811 79023379
Atrioventricular block complete 121.98 9.92 293 479905 16317 79247873
Myocardial ischaemia 121.41 9.92 384 479814 25135 79239055
Coronary artery occlusion 119.91 9.92 277 479921 15038 79249152
Blood loss anaemia 114.47 9.92 274 479924 15224 79248966
Psoriatic arthropathy 113.34 9.92 184 480014 77815 79186375
Abdominal discomfort 111.83 9.92 968 479230 249759 79014431
Pain 111.13 9.92 3309 476889 700493 78563697
Stomatitis 110.92 9.92 480 479718 146277 79117913
Ejection fraction 108.76 9.92 98 480100 2171 79262019
Nasopharyngitis 108.48 9.92 991 479207 252890 79011300
Acute kidney injury 108.31 9.92 3983 476215 515421 78748769
Wound 108.02 9.92 349 479849 115830 79148360
Exposure during pregnancy 107.69 9.92 285 479913 100847 79163343
Interstitial lung disease 107.67 9.92 334 479864 112266 79151924
Hepatic function abnormal 106.66 9.92 172 480026 72935 79191255
Pregnancy 106.42 9.92 17 480181 26834 79237356
Mucosal inflammation 104.56 9.92 184 480014 75396 79188794
Dyspnoea exertional 103.26 9.92 886 479312 86187 79178003
Sensitisation 102.98 9.92 113 480085 3198 79260992
Gastrointestinal disorder 102.90 9.92 383 479815 121822 79142368
Blood creatinine increased 102.25 9.92 1403 478795 153654 79110536
Drug resistance 101.96 9.92 64 480134 42149 79222041
Migraine 99.82 9.92 238 479960 87255 79176935
Coronary artery stenosis 97.96 9.92 226 479972 12258 79251932
Mobility decreased 97.04 9.92 392 479806 121783 79142407
Anti-neutrophil cytoplasmic antibody positive vasculitis 96.95 9.92 116 480082 3613 79260577
Inflammation 95.49 9.92 270 479928 93483 79170707
Haematoma 95.31 9.92 589 479609 51606 79212584
Ill-defined disorder 91.47 9.92 160 480038 65715 79198475
Red blood cell sedimentation rate increased 91.38 9.92 85 480113 45857 79218333
Anaemia 91.35 9.92 3407 476791 441608 78822582
Polycystic ovaries 90.85 9.92 113 480085 3666 79260524
Haemoglobin decreased 89.83 9.92 1856 478342 220263 79043927
Renal injury 89.20 9.92 264 479934 16663 79247527
Presyncope 88.44 9.92 484 479714 40570 79223620
Sopor 86.95 9.92 45 480153 32965 79231225
Hypertensive crisis 84.96 9.92 297 479901 20473 79243717
Pulmonary oedema 84.55 9.92 858 479340 87396 79176794
Urticaria 84.35 9.92 711 479487 184490 79079700
Mitral valve incompetence 83.17 9.92 367 479831 28198 79235992
Hip arthroplasty 82.58 9.92 57 480141 35699 79228491
Myelosuppression 82.00 9.92 73 480125 40223 79223967
Abortion spontaneous 79.56 9.92 39 480159 29468 79234722
Red blood cell sedimentation rate abnormal 79.30 9.92 15 480183 20948 79243242
Chronic kidney disease 77.83 9.92 672 479526 65482 79198708
Impaired healing 77.58 9.92 269 479929 87386 79176804
Neutrophil count decreased 77.45 9.92 297 479901 93662 79170528
Nodal arrhythmia 76.76 9.92 76 480122 1902 79262288
Nodal rhythm 75.78 9.92 94 480104 3041 79261149
Erythema 75.29 9.92 921 479277 222369 79041821
Transient ischaemic attack 74.91 9.92 559 479639 52136 79212054
Cerebral haemorrhage 74.87 9.92 599 479599 57074 79207116
Mental status changes 74.55 9.92 672 479526 66287 79197903
Therapeutic drug monitoring analysis not performed 72.58 9.92 73 480125 1863 79262327
Gout 72.07 9.92 318 479880 24431 79239759
Pulmonary renal syndrome 71.92 9.92 46 480152 594 79263596
Headache 70.98 9.92 3216 476982 650556 78613634
Atrioventricular block first degree 70.82 9.92 200 479998 12291 79251899
Cytomegalovirus infection 70.38 9.92 92 480106 42552 79221638
Medication error 69.95 9.92 676 479522 67966 79196224
Rash maculo-papular 69.30 9.92 146 480052 55932 79208258
Rheumatoid nodule 69.20 9.92 11 480187 17427 79246763
Bone marrow failure 68.38 9.92 127 480071 50980 79213210
Device expulsion 67.02 9.92 36 480162 25825 79238365
Ischaemic stroke 66.33 9.92 383 479815 32748 79231442
Pruritus 66.26 9.92 1839 478359 392809 78871381
Blood pressure increased 65.88 9.92 1703 478495 209657 79054533
Eosinophilia 65.84 9.92 107 480091 45238 79218952
Suicidal ideation 65.74 9.92 237 479961 76103 79188087
Hepatocellular injury 65.70 9.92 116 480082 47477 79216713
Sinus node dysfunction 65.55 9.92 144 480054 7557 79256633
Asthma 65.46 9.92 510 479688 134585 79129605
Bone erosion 64.95 9.92 14 480184 17833 79246357
Unresponsive to stimuli 64.22 9.92 564 479634 55224 79208966
Hypoglycaemia 64.01 9.92 912 479286 100682 79163508
Acute generalised exanthematous pustulosis 63.89 9.92 13 480185 17241 79246949
Arteriosclerosis 63.12 9.92 247 479951 17980 79246210
Lactic acidosis 62.65 9.92 674 479524 69685 79194505
Anhedonia 62.65 9.92 215 479983 14683 79249507
Febrile bone marrow aplasia 62.51 9.92 4 480194 13016 79251174
Blood test abnormal 62.15 9.92 241 479957 17469 79246721
Knee arthroplasty 60.99 9.92 104 480094 43144 79221046
Lower gastrointestinal haemorrhage 60.36 9.92 224 479974 15901 79248289
Liver disorder 60.27 9.92 228 479970 72189 79192001
Therapeutic product effect incomplete 59.97 9.92 554 479644 141091 79123099
Haemorrhage intracranial 59.95 9.92 314 479884 25879 79238311
Condition aggravated 59.33 9.92 2441 477757 498683 78765507
Haemophagocytic lymphohistiocytosis 58.67 9.92 29 480169 21808 79242382
Anaphylactic reaction 58.43 9.92 282 479916 83461 79180729
Pathogen resistance 57.02 9.92 9 480189 14333 79249857
Orthostatic intolerance 56.97 9.92 64 480134 1860 79262330
Fear 56.26 9.92 272 479926 21714 79242476
Pneumocystis jirovecii pneumonia 55.87 9.92 68 480130 32440 79231750
Arteriosclerosis coronary artery 55.79 9.92 234 479964 17582 79246608
Hyperlipidaemia 55.78 9.92 307 479891 25786 79238404
Troponin increased 55.76 9.92 247 479951 19008 79245182
Haematuria 55.64 9.92 647 479551 68189 79196001
Ventricular extrasystoles 54.99 9.92 250 479948 19454 79244736
Aortic stenosis 54.80 9.92 132 480066 7363 79256827
Coagulopathy 54.64 9.92 388 479810 35618 79228572
Torsade de pointes 54.62 9.92 246 479952 19066 79245124
Progressive multifocal leukoencephalopathy 54.38 9.92 28 480170 20572 79243618
Blood pressure inadequately controlled 54.28 9.92 117 480081 6060 79258130
Circulatory collapse 53.77 9.92 400 479798 37268 79226922
Atrial thrombosis 53.20 9.92 86 480112 3570 79260620
Drug eruption 52.95 9.92 116 480082 43819 79220371
Toxic skin eruption 52.20 9.92 35 480163 22258 79241932
Renal impairment 52.01 9.92 1281 478917 156502 79107688
Blood pressure decreased 51.59 9.92 864 479334 98602 79165588
Peripheral arterial occlusive disease 51.58 9.92 137 480061 8121 79256069
Haemorrhage 51.56 9.92 803 479395 90315 79173875
Blood glucose increased 51.22 9.92 975 479223 114000 79150190
Plasma cell myeloma 51.10 9.92 518 479680 52741 79211449
Cardiovascular disorder 50.53 9.92 229 479969 17796 79246394
Tachyarrhythmia 50.25 9.92 122 480076 6840 79257350
Myxoedema coma 50.20 9.92 39 480159 698 79263492
Blood cholesterol increased 50.04 9.92 297 479901 83423 79180767
Pallor 50.01 9.92 491 479707 49571 79214619
Sedation complication 49.97 9.92 16 480182 15653 79248537
Liver injury 49.25 9.92 175 480023 56439 79207751
Haematotoxicity 49.22 9.92 16 480182 15503 79248687
Glomerular filtration rate decreased 49.13 9.92 268 479930 22434 79241756
Therapeutic response decreased 49.07 9.92 221 479977 66632 79197558
Heart rate irregular 48.93 9.92 351 479847 32328 79231862
Supraventricular tachycardia 48.69 9.92 255 479943 21015 79243175
Panniculitis 48.65 9.92 8 480190 12363 79251827
Facet joint syndrome 47.49 9.92 6 480192 11296 79252894
Acute respiratory failure 47.40 9.92 558 479640 58983 79205207
Ventricular hypokinesia 47.26 9.92 143 480055 9136 79255054
Infective pulmonary exacerbation of cystic fibrosis 46.93 9.92 10 480188 12841 79251349
Ventricular arrhythmia 46.70 9.92 138 480060 8702 79255488
Malaise 46.55 9.92 2443 477755 487426 78776764
Injection site pain 46.25 9.92 529 479669 129309 79134881
Bronchiectasis 46.21 9.92 40 480158 22346 79241844
Cardiac failure chronic 46.21 9.92 160 480038 10975 79253215
Hyperthermia 45.45 9.92 26 480172 18011 79246179
Lymphopenia 45.41 9.92 71 480127 30486 79233704
Therapy partial responder 45.40 9.92 24 480174 17373 79246817
Upper gastrointestinal haemorrhage 45.39 9.92 414 479784 40966 79223224
Cholestasis 45.37 9.92 161 480037 51948 79212242
Product administration error 45.36 9.92 338 479860 31508 79232682
Ventricular fibrillation 44.99 9.92 338 479860 31588 79232602
Lung disorder 44.92 9.92 292 479906 80265 79183925
Bundle branch block left 44.83 9.92 162 480036 11351 79252839
Bronchopulmonary aspergillosis 44.63 9.92 41 480157 22253 79241937
Immune reconstitution inflammatory syndrome 44.38 9.92 14 480184 13827 79250363
Melaena 44.28 9.92 561 479637 60329 79203861
Septic shock 44.26 9.92 499 479699 122302 79141888
Grip strength decreased 44.04 9.92 40 480158 21829 79242361
Pericardial haemorrhage 44.01 9.92 89 480109 4406 79259784
Internal haemorrhage 43.94 9.92 135 480063 8698 79255492
Lip dry 43.71 9.92 19 480179 15399 79248791
Acute graft versus host disease 43.70 9.92 5 480193 10162 79254028
Granuloma skin 43.51 9.92 3 480195 9171 79255019
Epistaxis 43.47 9.92 927 479271 110588 79153602
Ejection fraction abnormal 43.41 9.92 63 480135 2377 79261813
Atrioventricular block second degree 43.35 9.92 119 480079 7193 79256997
Toxicity to various agents 43.29 9.92 3020 477178 418520 78845670
Sinus arrest 43.21 9.92 78 480120 3544 79260646
Unevaluable event 42.52 9.92 517 479681 55068 79209122
Acute lung injury 42.52 9.92 71 480127 3029 79261161
Heart rate abnormal 42.50 9.92 105 480093 5952 79258238
Aspergillus infection 42.35 9.92 32 480166 19129 79245061
Heart rate decreased 42.22 9.92 626 479572 69690 79194500
Bradyarrhythmia 41.68 9.92 83 480115 4063 79260127
Pleural effusion 41.39 9.92 1157 479041 144105 79120085
Agranulocytosis 41.33 9.92 136 480062 44894 79219296
Orthopnoea 41.16 9.92 144 480054 9929 79254261
Poisoning deliberate 40.90 9.92 32 480166 18796 79245394
Tendonitis 40.79 9.92 50 480148 23780 79240410
Fibromyalgia 40.73 9.92 224 479974 64116 79200074
Live birth 40.54 9.92 32 480166 18712 79245478
Nephrogenic systemic fibrosis 40.32 9.92 104 480094 6056 79258134
Adjustment disorder with depressed mood 40.25 9.92 4 480194 9082 79255108
Mouth ulceration 40.25 9.92 109 480089 38285 79225905
Drug tolerance decreased 40.08 9.92 14 480184 12964 79251226
Cardiac failure acute 39.99 9.92 222 479976 18707 79245483
Sedation 39.64 9.92 169 480029 51726 79212464
Tricuspid valve incompetence 39.54 9.92 228 479970 19484 79244706
Therapy non-responder 39.50 9.92 360 479838 91945 79172245
Hepatitis 39.25 9.92 187 480011 55540 79208650
Neutropenic sepsis 39.16 9.92 64 480134 27000 79237190
Device interaction 39.15 9.92 34 480164 716 79263474
Hypervolaemia 38.96 9.92 411 479787 42279 79221911
Post procedural haemorrhage 38.81 9.92 175 480023 13569 79250621
Multiple-drug resistance 38.70 9.92 4 480194 8804 79255386
Cardiac valve disease 38.69 9.92 98 480100 5643 79258547
Cardioversion 38.54 9.92 55 480143 2043 79262147
Pacemaker generated rhythm 38.39 9.92 15 480183 58 79264132
Cytomegalovirus infection reactivation 38.19 9.92 4 480194 8712 79255478
End stage renal disease 37.87 9.92 160 480038 12060 79252130
Occult blood positive 37.85 9.92 109 480089 6774 79257416
Foot deformity 37.65 9.92 54 480144 24020 79240170
Weight increased 37.42 9.92 1330 478868 276056 78988134
Ischaemic cardiomyopathy 36.79 9.92 116 480082 7579 79256611
Cardiac pacemaker insertion 36.78 9.92 97 480101 5725 79258465
Incorrect route of product administration 36.74 9.92 99 480099 34830 79229360
Peripheral vascular disorder 36.53 9.92 119 480079 7911 79256279
Anaphylactic shock 36.39 9.92 104 480094 35892 79228298
Essential hypertension 36.37 9.92 99 480099 5954 79258236
Tachycardia 36.37 9.92 1361 478837 176407 79087783
Chromaturia 35.95 9.92 272 479926 25474 79238716
Immunodeficiency 35.88 9.92 47 480151 21721 79242469
Venoocclusive liver disease 35.84 9.92 13 480185 11758 79252432
Pulmonary hypertension 35.83 9.92 445 479753 47635 79216555
Arterial haemorrhage 35.59 9.92 59 480139 2502 79261688
Renal disorder 35.48 9.92 399 479799 41706 79222484
Toxic epidermal necrolysis 35.40 9.92 143 480055 44438 79219752
Hypoaesthesia 35.35 9.92 816 479382 178536 79085654
Aortic valve incompetence 35.35 9.92 132 480066 9398 79254792
Unintentional medical device removal 35.22 9.92 3 480195 7709 79256481
Loss of employment 35.15 9.92 59 480139 2528 79261662
Aphthous ulcer 35.08 9.92 30 480168 16859 79247331
Hypovolaemia 35.08 9.92 204 479994 17487 79246703
Blood parathyroid hormone decreased 34.97 9.92 10 480188 10526 79253664
Electrolyte imbalance 34.91 9.92 311 479887 30570 79233620
Obstructive airways disorder 34.75 9.92 87 480111 31372 79232818
Electrocardiogram abnormal 34.50 9.92 195 480003 16542 79247648
Systemic infection 34.46 9.92 133 480065 9619 79254571
Thrombosis 34.36 9.92 704 479494 83396 79180794
Myocardial depression 33.89 9.92 27 480171 502 79263688
Malignant neoplasm progression 33.59 9.92 596 479602 135394 79128796
Vascular stent thrombosis 33.44 9.92 71 480127 3639 79260551
Full blood count decreased 33.42 9.92 276 479922 26543 79237647
Epstein-Barr virus infection 33.26 9.92 23 480175 14393 79249797
Body tinea 33.17 9.92 48 480150 1806 79262384
Ageusia 33.12 9.92 192 480006 16440 79247750
Drug level increased 33.08 9.92 375 479823 39276 79224914
Diverticulum intestinal haemorrhagic 33.01 9.92 74 480124 3937 79260253
Gastrointestinal tract mucosal pigmentation 32.94 9.92 36 480162 1014 79263176
Angioedema 32.57 9.92 641 479557 75394 79188796
Muscle necrosis 32.52 9.92 42 480156 1416 79262774
Nephrectomy 32.50 9.92 51 480147 2064 79262126
Acute graft versus host disease in skin 32.34 9.92 4 480194 7654 79256536
Rhinitis allergic 32.27 9.92 153 480045 12116 79252074
Decorticate posture 32.17 9.92 22 480176 320 79263870
Coronary artery dissection 32.09 9.92 37 480161 1107 79263083
Hypersensitivity myocarditis 31.96 9.92 20 480178 248 79263942
Pulseless electrical activity 31.89 9.92 169 480029 13991 79250199
Injection site reaction 31.87 9.92 196 480002 54589 79209601
Injection site erythema 31.74 9.92 309 479889 77888 79186302
Cardiomyopathy 31.62 9.92 288 479910 28486 79235704
Ejection fraction decreased 31.60 9.92 333 479865 34244 79229946
Electrocardiogram RR interval prolonged 31.39 9.92 9 480189 8 79264182
Hypertension 31.33 9.92 2356 477842 328636 78935554
Hiatus hernia 31.28 9.92 244 479954 23068 79241122
Blue toe syndrome 31.27 9.92 27 480171 564 79263626
Drug use disorder 31.05 9.92 7 480191 8644 79255546
Acute left ventricular failure 30.87 9.92 46 480152 1778 79262412
Fracture 30.83 9.92 231 479967 21570 79242620
Electrocardiogram QRS complex prolonged 30.64 9.92 138 480060 10695 79253495
Coma 30.63 9.92 424 479774 100225 79163965
Autoimmune disorder 30.44 9.92 33 480165 16579 79247611
Prescribed overdose 30.41 9.92 121 480077 37762 79226428
International normalised ratio decreased 30.12 9.92 112 480086 7958 79256232
Fluid retention 30.06 9.92 589 479609 69220 79194970
Chronic graft versus host disease 30.00 9.92 3 480195 6778 79257412
Breast cancer stage I 29.55 9.92 3 480195 6697 79257493
Hypogammaglobulinaemia 29.44 9.92 21 480177 12930 79251260
Appendicitis 29.32 9.92 50 480148 20744 79243446
Drug dependence 29.19 9.92 136 480062 40633 79223557
Device adhesion issue 29.14 9.92 4 480194 7071 79257119
Nodule 29.14 9.92 59 480139 22935 79241255
Heart rate increased 28.85 9.92 941 479257 119783 79144407
Low density lipoprotein abnormal 28.50 9.92 23 480175 436 79263754
Graft versus host disease 28.49 9.92 29 480169 14997 79249193
Hip fracture 28.46 9.92 297 479901 30464 79233726
Cardiac operation 28.17 9.92 80 480118 4932 79259258
Abdominal pain lower 28.07 9.92 304 479894 31478 79232712
Cardiomegaly 28.07 9.92 262 479936 26090 79238100
Tuberculosis 28.06 9.92 30 480168 15168 79249022
Cardiac output decreased 27.80 9.92 44 480154 1794 79262396
Diverticulum intestinal 27.71 9.92 114 480084 8491 79255699
Pulmonary fibrosis 27.69 9.92 154 480044 43958 79220232
Epilepsy 27.68 9.92 139 480059 40721 79223469
Blood pressure systolic abnormal 27.66 9.92 38 480160 17209 79246981
Chronotropic incompetence 27.54 9.92 13 480185 87 79264103
Exercise tolerance decreased 27.51 9.92 118 480080 8953 79255237
Type 2 diabetes mellitus 27.49 9.92 216 479982 56906 79207284
Product quality issue 27.42 9.92 319 479879 33621 79230569
Stent placement 27.33 9.92 94 480104 6426 79257764
Colorectal cancer 27.27 9.92 9 480189 8638 79255552
Disseminated intravascular coagulation 27.20 9.92 117 480081 35725 79228465
Body height decreased 27.10 9.92 113 480085 8467 79255723
Dystonia 27.04 9.92 55 480143 21344 79242846
Joint range of motion decreased 26.91 9.92 106 480092 33176 79231014
Extrasystoles 26.89 9.92 102 480096 7317 79256873
Ovarian cyst 26.88 9.92 22 480176 12633 79251557
Neuroleptic malignant syndrome 26.86 9.92 81 480117 27478 79236712
Alanine aminotransferase increased 26.85 9.92 759 479439 161811 79102379
Post transplant lymphoproliferative disorder 26.84 9.92 18 480180 11446 79252744
Blood potassium increased 26.78 9.92 282 479916 28993 79235197
Pulse absent 26.58 9.92 126 480072 9977 79254213
Lymphocyte count decreased 26.57 9.92 171 480027 47118 79217072
Bundle branch block right 26.52 9.92 136 480062 11115 79253075
Electrocardiogram T wave abnormal 26.44 9.92 65 480133 3673 79260517
Device capturing issue 26.14 9.92 10 480188 36 79264154
Uveitis 26.07 9.92 38 480160 16792 79247398
Product substitution issue 26.07 9.92 210 479988 20046 79244144
Colitis ulcerative 26.00 9.92 114 480084 34628 79229562
Carpal tunnel syndrome 25.98 9.92 204 479994 19324 79244866
Aggression 25.79 9.92 190 480008 50768 79213422
Device dislocation 25.55 9.92 76 480122 25894 79238296
Diarrhoea 25.46 9.92 5827 474371 874662 78389528
Blood albumin abnormal 25.40 9.92 26 480172 678 79263512
Hypomania 25.34 9.92 7 480191 7537 79256653
Idiopathic pulmonary fibrosis 25.26 9.92 69 480129 4159 79260031
Vomiting 25.21 9.92 3570 476628 662258 78601932
Pulmonary tuberculosis 25.14 9.92 8 480190 7857 79256333
Cardiac ablation 24.97 9.92 47 480151 2206 79261984
Fatigue 24.94 9.92 6132 474066 923595 78340595
Cystitis haemorrhagic 24.91 9.92 12 480186 9160 79255030
Product solubility abnormal 24.88 9.92 30 480168 942 79263248
Aortic valve sclerosis 24.73 9.92 41 480157 1739 79262451
X-ray abnormal 24.64 9.92 3 480195 5810 79258380
Gastrointestinal toxicity 24.61 9.92 9 480189 8100 79256090
Disability 24.29 9.92 41 480157 17079 79247111
Left atrial enlargement 24.28 9.92 33 480165 1170 79263020
Myocardial hypoxia 24.26 9.92 8 480190 16 79264174
Immune-mediated myositis 24.22 9.92 60 480138 3407 79260783
Oral candidiasis 24.18 9.92 94 480104 29534 79234656
Mitral valve stenosis 24.13 9.92 33 480165 1177 79263013
Sleep disorder due to a general medical condition 24.13 9.92 158 480040 14119 79250071
Echocardiogram abnormal 24.10 9.92 46 480152 2182 79262008
Prostatomegaly 24.04 9.92 60 480138 3423 79260767
Hepatitis B reactivation 23.91 9.92 4 480194 6104 79258086
Mucosal haemorrhage 23.90 9.92 50 480148 2536 79261654
Basal ganglia haemorrhage 23.90 9.92 39 480159 1632 79262558
Coeliac disease 23.78 9.92 20 480178 11331 79252859
Non-cardiac chest pain 23.77 9.92 117 480081 9407 79254783
Retinitis 23.70 9.92 3 480195 5640 79258550
Thrombotic microangiopathy 23.69 9.92 54 480144 20115 79244075
Carotid artery stenosis 23.61 9.92 110 480088 8648 79255542
Blood sodium decreased 23.59 9.92 305 479893 32950 79231240
Irritability 23.51 9.92 148 480050 40996 79223194
Hypertensive heart disease 23.51 9.92 67 480131 4139 79260051
Product residue present 23.45 9.92 60 480138 3476 79260714
Left ventricular failure 23.42 9.92 117 480081 9464 79254726
Penis injury 23.32 9.92 13 480185 128 79264062
Orthostatic hypotension 23.22 9.92 471 479727 55693 79208497
Blood glucose decreased 23.20 9.92 251 479947 25983 79238207
Wheezing 23.20 9.92 530 479668 116134 79148056
Blood urea increased 23.20 9.92 418 479780 48372 79215818
Coronary artery restenosis 23.19 9.92 34 480164 1295 79262895
Forced expiratory volume decreased 23.17 9.92 9 480189 7805 79256385
Graft versus host disease in gastrointestinal tract 23.10 9.92 5 480193 6351 79257839
Mitral valve disease 23.05 9.92 56 480142 3141 79261049
Labile hypertension 23.00 9.92 22 480176 527 79263663
Left ventricular dysfunction 22.93 9.92 197 480001 19164 79245026
Arthritis 22.81 9.92 522 479676 114358 79149832
Intraventricular haemorrhage 22.75 9.92 73 480125 4814 79259376
Paraesthesia 22.73 9.92 850 479348 175473 79088717
Substance abuse 22.73 9.92 18 480180 10508 79253682
Chronic sinusitis 22.65 9.92 27 480171 12999 79251191
Poor venous access 22.63 9.92 47 480151 18102 79246088
Amenorrhoea 22.58 9.92 9 480189 7683 79256507
Dialysis 22.47 9.92 189 480009 18273 79245917
Implantable defibrillator insertion 22.38 9.92 29 480169 981 79263209
Tooth erosion 22.32 9.92 19 480179 389 79263801
Dementia 22.31 9.92 237 479961 24422 79239768
Colitis 22.24 9.92 309 479889 72998 79191192
Human herpesvirus 6 infection 22.21 9.92 3 480195 5367 79258823
Bursitis 22.03 9.92 126 480072 35718 79228472
Aortic aneurysm 21.98 9.92 105 480093 8341 79255849
Haemarthrosis 21.97 9.92 81 480117 5731 79258459
Aplastic anaemia 21.80 9.92 47 480151 17858 79246332
Hyperthyroidism 21.78 9.92 217 479981 21992 79242198
Lacunar infarction 21.67 9.92 82 480116 5875 79258315
Haemorrhagic stroke 21.66 9.92 127 480071 10919 79253271
Aplasia 21.60 9.92 10 480188 7810 79256380
Blood potassium decreased 21.59 9.92 397 479801 46115 79218075
QRS axis abnormal 21.43 9.92 42 480156 2032 79262158
Blood creatine increased 21.40 9.92 113 480085 9342 79254848
Electrocardiogram PR prolongation 21.37 9.92 36 480162 1547 79262643
Diffuse large B-cell lymphoma 21.32 9.92 25 480173 12124 79252066
Lymphoproliferative disorder 21.28 9.92 4 480194 5611 79258579
High density lipoprotein decreased 21.19 9.92 69 480129 4586 79259604
Neuropathy peripheral 21.03 9.92 669 479529 140636 79123554
Urinary tract infection 21.01 9.92 1923 478275 272589 78991601
Thrombin time prolonged 20.94 9.92 17 480181 325 79263865
Joint destruction 20.85 9.92 5 480193 5920 79258270
Drug-disease interaction 20.71 9.92 29 480169 1058 79263132
Thrombocytopenia 20.62 9.92 1348 478850 263911 79000279
Faeces discoloured 20.60 9.92 267 479931 28860 79235330
CD30 expression 20.59 9.92 9 480189 49 79264141
Prothrombin time prolonged 20.57 9.92 173 480025 16726 79247464
Faeces pale 20.55 9.92 51 480147 2899 79261291
Hypertransaminasaemia 20.43 9.92 25 480173 11899 79252291
Anastomotic infection 20.40 9.92 12 480186 132 79264058
Hyperammonaemia 20.37 9.92 22 480176 11071 79253119
Shock 20.32 9.92 372 479826 43176 79221014
Abnormal behaviour 20.31 9.92 132 480066 36289 79227901
Muscle spasticity 20.31 9.92 64 480134 21411 79242779
Joint stiffness 20.30 9.92 153 480045 40677 79223513
Iliac artery stenosis 20.25 9.92 13 480185 169 79264021
Gastrointestinal arteriovenous malformation 20.22 9.92 27 480171 941 79263249
Duodenal ulcer 20.15 9.92 168 480030 16201 79247989
Coronary angioplasty 20.12 9.92 18 480180 395 79263795
Sleep disorder 20.05 9.92 379 479819 85298 79178892
Vascular resistance pulmonary decreased 20.02 9.92 10 480188 77 79264113
Type IIa hyperlipidaemia 20.01 9.92 15 480183 254 79263936
Carcinoma in situ of skin 19.99 9.92 13 480185 173 79264017
Vaginal discharge 19.91 9.92 10 480188 7453 79256737
Hypoperfusion 19.86 9.92 47 480151 2592 79261598
International normalised ratio abnormal 19.84 9.92 78 480120 5690 79258500
Extrapyramidal disorder 19.79 9.92 70 480128 22609 79241581
Mitral valve sclerosis 19.76 9.92 15 480183 259 79263931
Peripheral artery occlusion 19.74 9.92 46 480152 2511 79261679
Depressive symptom 19.71 9.92 7 480191 6416 79257774
Sleep apnoea syndrome 19.69 9.92 319 479879 36159 79228031
Penile haemorrhage 19.68 9.92 20 480178 517 79263673
Degenerative aortic valve disease 19.61 9.92 13 480185 179 79264011
Ear infection 19.60 9.92 124 480074 34308 79229882
Anticoagulation drug level above therapeutic 19.59 9.92 57 480141 3563 79260627
Nocardiosis 19.59 9.92 5 480193 5674 79258516
Pharyngitis 19.57 9.92 69 480129 22306 79241884
Diverticulum 19.48 9.92 155 480043 14741 79249449
Enterocolitis 19.46 9.92 36 480162 14476 79249714
Status epilepticus 19.46 9.92 81 480117 24960 79239230
Blood pressure abnormal 19.46 9.92 173 480025 16996 79247194
Chronic obstructive pulmonary disease 19.43 9.92 662 479536 84757 79179433
Phaeochromocytoma 19.43 9.92 22 480176 645 79263545
Gouty arthritis 19.43 9.92 33 480165 1428 79262762
Erectile dysfunction 19.41 9.92 153 480045 14511 79249679
Intentional self-injury 19.37 9.92 115 480083 32304 79231886
Intestinal atony 19.35 9.92 8 480190 37 79264153
Inspiratory capacity abnormal 19.34 9.92 11 480187 113 79264077
Myopathy 19.24 9.92 199 479999 20364 79243826
Schizophrenia 19.24 9.92 40 480158 15400 79248790
Carcinoid tumour 19.07 9.92 20 480178 537 79263653
Dysgeusia 19.06 9.92 465 479733 56712 79207478
Subchondral insufficiency fracture 18.85 9.92 9 480189 62 79264128
Non-cardiogenic pulmonary oedema 18.81 9.92 33 480165 1466 79262724
Skin induration 18.76 9.92 65 480133 4460 79259730
Pneumonia aspiration 18.66 9.92 287 479911 66680 79197510
Secretion discharge 18.65 9.92 39 480159 14983 79249207
Cytomegalovirus chorioretinitis 18.62 9.92 5 480193 5485 79258705
Catheterisation cardiac 18.53 9.92 76 480122 5652 79258538
Fear of injection 18.51 9.92 11 480187 7463 79256727
Allergic reaction to excipient 18.46 9.92 16 480182 336 79263854
Dizziness postural 18.43 9.92 126 480072 11423 79252767
Cerebrospinal fluid retention 18.33 9.92 10 480188 94 79264096
Cytokine release syndrome 18.32 9.92 134 480064 35864 79228326
Retching 18.27 9.92 173 480025 17294 79246896
Sudden cardiac death 18.25 9.92 71 480127 5154 79259036
Ischaemic hepatitis 18.23 9.92 56 480142 3608 79260582
Hypoxia 18.21 9.92 778 479420 102465 79161725
Therapeutic response shortened 18.20 9.92 43 480155 15820 79248370
Antiacetylcholine receptor antibody positive 18.16 9.92 9 480189 68 79264122
Dyskinesia 18.13 9.92 177 480021 44596 79219594
Retroperitoneal haemorrhage 18.03 9.92 73 480125 5397 79258793
Embolic stroke 18.03 9.92 94 480104 7732 79256458
Graft versus host disease in skin 18.00 9.92 7 480191 6066 79258124
Cerebral artery occlusion 17.95 9.92 35 480163 1687 79262503
Multiple injuries 17.93 9.92 54 480144 3441 79260749
Hospice care 17.91 9.92 115 480083 10209 79253981
Diastolic dysfunction 17.88 9.92 119 480079 10692 79253498
Glucose tolerance impaired 17.87 9.92 96 480102 7988 79256202
Coronary artery thrombosis 17.87 9.92 50 480148 3056 79261134
Dilatation atrial 17.86 9.92 56 480142 3648 79260542
Erythema multiforme 17.84 9.92 51 480147 17600 79246590
Lymphatic fistula 17.71 9.92 23 480175 780 79263410
Infection susceptibility increased 17.70 9.92 56 480142 3665 79260525
Conjunctivitis 17.69 9.92 87 480111 25628 79238562
Injection site pruritus 17.62 9.92 166 480032 42117 79222073
Blood urine present 17.57 9.92 201 479997 21096 79243094
Exostosis 17.57 9.92 48 480150 16810 79247380
Left-to-right cardiac shunt 17.56 9.92 10 480188 103 79264087
Chronic left ventricular failure 17.54 9.92 26 480172 1000 79263190
Female genital tract fistula 17.52 9.92 7 480191 5968 79258222
Cardiorenal syndrome 17.42 9.92 33 480165 1556 79262634
Serotonin syndrome 17.41 9.92 180 480018 44847 79219343
Patent ductus arteriosus 17.39 9.92 10 480188 105 79264085
Obsessive-compulsive disorder 17.29 9.92 7 480191 5920 79258270
Withdrawal hypertension 17.26 9.92 16 480182 368 79263822
Computerised tomogram head abnormal 17.23 9.92 10 480188 107 79264083
Low cardiac output syndrome 17.18 9.92 26 480172 1019 79263171
Albumin urine present 17.16 9.92 21 480177 670 79263520
Gastritis erosive 17.11 9.92 118 480080 10729 79253461
Hepatitis B 17.06 9.92 15 480183 8317 79255873
Heart valve incompetence 17.03 9.92 51 480147 3240 79260950
Exposure via ingestion 17.02 9.92 69 480129 5105 79259085
Transplant rejection 16.96 9.92 60 480138 19377 79244813
Flatulence 16.91 9.92 356 479842 42368 79221822
Heparin-induced thrombocytopenia 16.89 9.92 108 480090 9574 79254616
Immune thrombocytopenia 16.88 9.92 53 480145 17752 79246438
Prostate cancer 16.86 9.92 124 480074 33144 79231046
Hyperbilirubinaemia 16.84 9.92 83 480115 24435 79239755
Device use error 16.83 9.92 11 480187 7090 79257100
Maternal exposure before pregnancy 16.82 9.92 3 480195 4370 79259820
Emotional distress 16.79 9.92 336 479862 39633 79224557
Sciatica 16.75 9.92 124 480074 33098 79231092
Parathyroid hormone-related protein abnormal 16.75 9.92 6 480192 17 79264173
Lymphadenopathy 16.67 9.92 223 479975 53024 79211166
Oral herpes 16.61 9.92 97 480101 27357 79236833
Hepatojugular reflux 16.59 9.92 20 480178 628 79263562
Leukoencephalopathy 16.57 9.92 14 480184 7915 79256275
Renal atrophy 16.53 9.92 35 480163 1790 79262400
Acidosis 16.53 9.92 187 480011 19575 79244615
Cardiovascular somatic symptom disorder 16.50 9.92 7 480191 35 79264155
Catatonia 16.49 9.92 17 480181 8739 79255451
Acne 16.48 9.92 96 480102 27094 79237096
Listless 16.48 9.92 56 480142 3805 79260385
Systemic candida 16.43 9.92 10 480188 6696 79257494
Product dose omission issue 16.30 9.92 1716 478482 245821 79018369
Lower limb fracture 16.29 9.92 78 480120 23137 79241053
Oesophageal carcinoma 16.23 9.92 26 480172 11058 79253132
Eructation 16.23 9.92 117 480081 10792 79253398
Aortic valve stenosis 16.16 9.92 69 480129 5225 79258965
Oesophageal obstruction 16.13 9.92 25 480173 1001 79263189
Abdominal pain 16.11 9.92 2077 478121 387492 78876698
Hepatotoxicity 16.10 9.92 215 479983 51137 79213053
Adverse drug reaction 16.06 9.92 292 479906 66100 79198090
Metastases to bone 16.04 9.92 84 480114 24343 79239847
Ulcer 16.02 9.92 110 480088 29862 79234328
Head injury 15.99 9.92 315 479883 37054 79227136
Micturition disorder 15.96 9.92 57 480141 3971 79260219
Haemorrhoidal haemorrhage 15.92 9.92 82 480116 6713 79257477
Loss of personal independence in daily activities 15.91 9.92 483 479715 102097 79162093
Subdural haematoma 15.91 9.92 272 479926 31162 79233028
Respiratory disorder 15.87 9.92 183 480015 44673 79219517
Hypoalbuminaemia 15.87 9.92 70 480128 21227 79242963
Cerebellar haemorrhage 15.82 9.92 46 480152 2874 79261316
Upper motor neurone lesion 15.82 9.92 13 480185 253 79263937
Rectal haemorrhage 15.79 9.92 585 479613 75715 79188475
Anticoagulation drug level below therapeutic 15.79 9.92 31 480167 1502 79262688
Laryngitis 15.73 9.92 47 480151 15992 79248198
Acute myeloid leukaemia 15.70 9.92 115 480083 30770 79233420
Malignant polyp 15.69 9.92 11 480187 167 79264023
Ascites 15.67 9.92 341 479857 75221 79188969
Injection site swelling 15.64 9.92 195 480003 46937 79217253
Neurotoxicity 15.63 9.92 123 480075 32395 79231795
Carotid artery disease 15.63 9.92 39 480159 2225 79261965
Portal fibrosis 15.62 9.92 19 480179 602 79263588
Rash erythematous 15.62 9.92 249 479949 57520 79206670
Neutrophil function disorder 15.60 9.92 6 480192 22 79264168
Generalised tonic-clonic seizure 15.59 9.92 179 480019 43731 79220459
Calciphylaxis 15.50 9.92 54 480144 3716 79260474
Thoracic haemorrhage 15.48 9.92 12 480186 214 79263976
Dry eye 15.38 9.92 145 480053 36786 79227404
Femoral hernia incarcerated 15.36 9.92 22 480176 820 79263370
Disease progression 15.34 9.92 931 479267 183431 79080759
Peripheral venous disease 15.33 9.92 47 480151 15862 79248328
Cytomegalovirus viraemia 15.32 9.92 34 480164 12787 79251403
Conjunctival haemorrhage 15.32 9.92 73 480125 5792 79258398
Hypoaldosteronism 15.29 9.92 15 480183 371 79263819
Hypokalaemia 15.28 9.92 1035 479163 143005 79121185
Aortic arteriosclerosis 15.26 9.92 99 480099 8819 79255371
Pancytopenia 15.24 9.92 829 479369 164916 79099274
Haemodynamic instability 15.23 9.92 166 480032 17216 79246974
Macrophages increased 15.20 9.92 13 480185 268 79263922
Haemorrhagic transformation stroke 15.16 9.92 43 480155 2649 79261541
Haemoptysis 15.10 9.92 443 479755 55556 79208634
Phaeochromocytoma crisis 15.07 9.92 14 480184 323 79263867
Traumatic haemorrhage 15.01 9.92 28 480170 1305 79262885
Paranoia 15.01 9.92 63 480135 19369 79244821
Non-high-density lipoprotein cholesterol increased 14.93 9.92 14 480184 327 79263863
Actinic keratosis 14.92 9.92 74 480124 5968 79258222
Arteriosclerotic gangrene 14.87 9.92 8 480190 73 79264117
Deep vein thrombosis 14.86 9.92 880 479318 120039 79144151
Muscular weakness 14.83 9.92 1142 479056 159587 79104603
Herpes simplex 14.83 9.92 32 480166 12155 79252035
Pericardial effusion 14.80 9.92 374 479824 45863 79218327
Loss of consciousness 14.80 9.92 1189 479009 166754 79097436
Thalamus haemorrhage 14.80 9.92 33 480165 1749 79262441
Supraventricular extrasystoles 14.79 9.92 82 480116 6905 79257285
Haemodialysis 14.78 9.92 171 480027 17997 79246193
Acute lymphocytic leukaemia recurrent 14.75 9.92 5 480193 4719 79259471
Hypercalcaemia 14.70 9.92 154 480044 38276 79225914
Vasoconstriction 14.70 9.92 20 480178 710 79263480
Metabolic syndrome 14.69 9.92 43 480155 2697 79261493
Hemiparesis 14.65 9.92 285 479913 33448 79230742
Demyelination 14.63 9.92 16 480182 8007 79256183
Cell death 14.63 9.92 5 480193 4694 79259496
Skin tightness 14.62 9.92 69 480129 5453 79258737
Diabetic nephropathy 14.62 9.92 45 480153 2902 79261288
Seronegative arthritis 14.60 9.92 5 480193 4687 79259503
Hypomagnesaemia 14.59 9.92 378 479820 46533 79217657
Blood alkaline phosphatase abnormal 14.58 9.92 22 480176 860 79263330
Throat irritation 14.50 9.92 167 480031 40779 79223411
Electrocardiogram ST segment depression 14.45 9.92 63 480135 4815 79259375
Peripheral sensory neuropathy 14.43 9.92 36 480162 12997 79251193
Ventricular hypertrophy 14.41 9.92 81 480117 6857 79257333
Food allergy 14.39 9.92 27 480171 10797 79253393
Accidental exposure to product 14.35 9.92 120 480078 31202 79232988
Autoimmune myositis 14.35 9.92 13 480185 290 79263900
Flushing 14.34 9.92 413 479785 87855 79176335
Osteonecrosis 14.31 9.92 119 480079 30976 79233214
Cardiovascular insufficiency 14.31 9.92 45 480153 2936 79261254
Strongyloidiasis 14.30 9.92 3 480195 3895 79260295
Disturbance in social behaviour 14.29 9.92 6 480192 4964 79259226
Autoimmune myocarditis 14.26 9.92 15 480183 404 79263786
Jaundice cholestatic 14.26 9.92 29 480169 11255 79252935
Pleural mass 14.25 9.92 8 480190 80 79264110
Hepatitis acute 14.22 9.92 47 480151 15495 79248695
Peripheral coldness 14.22 9.92 153 480045 15817 79248373
Seroma 14.20 9.92 38 480160 2262 79261928
Multiple sclerosis relapse 14.16 9.92 196 480002 46337 79217853
Shone complex 14.14 9.92 6 480192 30 79264160
Mitral valve hypoplasia 14.14 9.92 6 480192 30 79264160
Oropharyngeal pain 14.12 9.92 527 479671 108826 79155364
Blood creatinine abnormal 14.10 9.92 62 480136 4755 79259435
Polyarthritis 14.06 9.92 33 480165 12169 79252021
Aortic valve replacement 14.04 9.92 27 480171 1288 79262902
Drug tolerance 14.02 9.92 19 480179 8656 79255534
Onychomadesis 14.02 9.92 7 480191 5235 79258955
Congenital aortic valve stenosis 13.98 9.92 6 480192 31 79264159
Alveolitis 13.95 9.92 56 480142 4124 79260066
Autoimmune haemolytic anaemia 13.91 9.92 18 480180 8362 79255828
Multiple drug therapy 13.91 9.92 55 480143 4023 79260167
Cold sweat 13.90 9.92 173 480025 18526 79245664
Metastases to fallopian tube 13.89 9.92 7 480191 55 79264135
Left ventricular hypertrophy 13.85 9.92 115 480083 11076 79253114
Disseminated tuberculosis 13.83 9.92 4 480194 4179 79260011
Aorta hypoplasia 13.83 9.92 6 480192 32 79264158
Renal cell carcinoma 13.79 9.92 77 480121 6501 79257689
Tumour lysis syndrome 13.74 9.92 86 480112 23853 79240337
Dermatitis exfoliative generalised 13.70 9.92 14 480184 7227 79256963
Neuropathy vitamin B12 deficiency 13.68 9.92 8 480190 87 79264103
Leukopenia 13.64 9.92 568 479630 115945 79148245
Nocturia 13.57 9.92 134 480064 13547 79250643
Osteoarthritis 13.56 9.92 411 479787 86898 79177292
Ultrasound kidney abnormal 13.53 9.92 6 480192 34 79264156
Total cholesterol/HDL ratio increased 13.50 9.92 12 480186 261 79263929
Embolic cerebral infarction 13.45 9.92 26 480172 1245 79262945
Cardioactive drug level increased 13.45 9.92 51 480147 3658 79260532
Osteoporosis 13.40 9.92 237 479961 53875 79210315
Bundle branch block bilateral 13.38 9.92 7 480191 60 79264130
Skin hypertrophy 13.36 9.92 62 480136 4866 79259324
Histology abnormal 13.31 9.92 13 480185 320 79263870
Posterior reversible encephalopathy syndrome 13.29 9.92 98 480100 26183 79238007
Myocardial bridging 13.29 9.92 5 480193 17 79264173
Encephalitis 13.25 9.92 45 480153 14715 79249475
Blood pressure immeasurable 13.24 9.92 35 480163 2069 79262121
Procedural pain 13.21 9.92 83 480115 23001 79241189
Clonus 13.20 9.92 13 480185 6827 79257363
Diabetic neuropathy 13.19 9.92 73 480125 6143 79258047
HELLP syndrome 13.17 9.92 20 480178 786 79263404
Intracardiac thrombus 13.14 9.92 56 480142 4237 79259953
Mydriasis 13.14 9.92 58 480140 17585 79246605
Drug dose omission by device 13.11 9.92 11 480187 6239 79257951
Hyperparathyroidism 13.10 9.92 46 480152 3178 79261012
Facial bones fracture 13.09 9.92 63 480135 5019 79259171
Heavy menstrual bleeding 13.08 9.92 42 480156 13969 79250221
Illness 13.07 9.92 199 479999 46312 79217878
Menstruation irregular 13.06 9.92 7 480191 5029 79259161
Arteriospasm coronary 13.03 9.92 77 480121 6639 79257551
Aspartate aminotransferase increased 13.01 9.92 692 479506 137949 79126241
Gastric cancer 13.00 9.92 26 480172 10153 79254037
Gastric ulcer 12.93 9.92 281 479917 33624 79230566
Cardiac function test abnormal 12.93 9.92 9 480189 135 79264055
Conjunctival cyst 12.91 9.92 7 480191 65 79264125
Ear pain 12.87 9.92 131 480067 32738 79231452
Ischaemia 12.83 9.92 88 480110 7987 79256203
Left atrial dilatation 12.82 9.92 45 480153 3108 79261082
Electrocardiogram ST-T segment abnormal 12.81 9.92 17 480181 589 79263601
Seizure 12.80 9.92 971 479227 187863 79076327
Alanine aminotransferase abnormal 12.80 9.92 21 480177 8846 79255344
Inferior vena cava syndrome 12.80 9.92 8 480190 99 79264091
Lipodystrophy acquired 12.79 9.92 5 480193 4320 79259870
Sprue-like enteropathy 12.79 9.92 26 480172 1292 79262898
Hypertriglyceridaemia 12.74 9.92 37 480161 12703 79251487
Congenital heart valve disorder 12.73 9.92 6 480192 40 79264150
Blepharospasm 12.64 9.92 10 480188 5841 79258349
Bacterial parotitis 12.61 9.92 6 480192 41 79264149
Palmar-plantar erythrodysaesthesia syndrome 12.59 9.92 133 480065 33001 79231189
Device difficult to use 12.58 9.92 40 480158 13345 79250845
Kidney rupture 12.58 9.92 11 480187 234 79263956
Central nervous system lesion 12.53 9.92 40 480158 13328 79250862
Sodium retention 12.50 9.92 10 480188 187 79264003
Mood altered 12.50 9.92 60 480138 17787 79246403
Venous pressure jugular increased 12.49 9.92 26 480172 1314 79262876
Arteriovenous fistula occlusion 12.47 9.92 16 480182 536 79263654
Finger deformity 12.46 9.92 16 480182 7458 79256732
Breast cancer female 12.42 9.92 32 480166 11429 79252761
Skin fibrosis 12.41 9.92 28 480170 1496 79262694
Rheumatoid lung 12.40 9.92 5 480193 4240 79259950
Eczema 12.40 9.92 172 480026 40646 79223544
Aspiration pleural cavity 12.39 9.92 29 480169 1588 79262602
Extra dose administered 12.37 9.92 90 480108 8325 79255865
Dermatitis acneiform 12.36 9.92 26 480172 9967 79254223
Venous pressure jugular abnormal 12.36 9.92 3 480195 0 79264190
Diabetic dermopathy 12.36 9.92 3 480195 0 79264190
Alveolar-arterial oxygen gradient increased 12.36 9.92 3 480195 0 79264190
Drug screen 12.36 9.92 3 480195 0 79264190
Defaecation disorder 12.33 9.92 18 480180 683 79263507
Fungal infection 12.30 9.92 177 480021 41571 79222619
Frequent bowel movements 12.29 9.92 116 480082 29423 79234767
Cerebral ischaemia 12.27 9.92 112 480086 11083 79253107
Dyschromatopsia 12.25 9.92 20 480178 837 79263353
Road traffic accident 12.21 9.92 187 480011 43477 79220713
Drug ineffective for unapproved indication 12.19 9.92 226 479972 51012 79213178
Hypoacusis 12.18 9.92 252 479946 29898 79234292
Sickle cell anaemia with crisis 12.16 9.92 18 480180 7904 79256286
Herpes zoster 12.15 9.92 448 479750 92635 79171555
Uterine perforation 12.14 9.92 12 480186 6291 79257899
Subarachnoid haemorrhage 12.13 9.92 211 479987 24254 79239936
Depression suicidal 12.12 9.92 4 480194 3838 79260352
Device related infection 12.10 9.92 140 480058 34154 79230036
Femur fracture 12.05 9.92 162 480036 38490 79225700
Tenderness 12.04 9.92 88 480110 23554 79240636
Paraesthesia oral 12.03 9.92 73 480125 20398 79243792
Disability assessment scale score increased 12.01 9.92 3 480195 3455 79260735
Needle issue 12.01 9.92 126 480072 12942 79251248
COVID-19 11.95 9.92 803 479395 156871 79107319
Aortic valve disease 11.92 9.92 32 480166 1909 79262281
Biopsy lymph gland 11.90 9.92 8 480190 113 79264077
Initial insomnia 11.86 9.92 77 480121 6861 79257329
Sleep terror 11.86 9.92 6 480192 4452 79259738
Adverse event 11.84 9.92 274 479924 59940 79204250
Left ventricular false tendon 11.82 9.92 6 480192 48 79264142
Joint effusion 11.80 9.92 62 480136 17952 79246238
Sarcoidosis 11.79 9.92 20 480178 8315 79255875
Supravalvular aortic stenosis 11.78 9.92 5 480193 25 79264165
Congenital aortic anomaly 11.78 9.92 5 480193 25 79264165
Congenital aortic stenosis 11.78 9.92 5 480193 25 79264165
Retroperitoneal haematoma 11.78 9.92 63 480135 5234 79258956
Electrocardiogram QRS complex shortened 11.77 9.92 18 480180 712 79263478
Vascular access site occlusion 11.75 9.92 7 480191 79 79264111
Fracture blisters 11.75 9.92 7 480191 79 79264111
Apallic syndrome 11.74 9.92 21 480177 947 79263243
Intracranial pressure increased 11.74 9.92 20 480178 8302 79255888
Metastatic renal cell carcinoma 11.72 9.92 36 480162 2319 79261871
White blood cell count decreased 11.71 9.92 975 479223 187313 79076877
Unwanted awareness during anaesthesia 11.69 9.92 12 480186 314 79263876
Muscle oedema 11.68 9.92 9 480189 159 79264031
Sacroiliitis 11.68 9.92 4 480194 3750 79260440
Vascular device infection 11.68 9.92 28 480170 10248 79253942
Spondylitis 11.66 9.92 7 480191 4724 79259466
Blood creatine phosphokinase MB abnormal 11.63 9.92 5 480193 26 79264164
Pancreatic steatosis 11.60 9.92 23 480175 1122 79263068
Erythema nodosum 11.60 9.92 9 480189 5308 79258882
Retinal vascular disorder 11.57 9.92 12 480186 318 79263872
Hyperlactacidaemia 11.55 9.92 10 480188 5585 79258605
Lupus pneumonitis 11.52 9.92 7 480191 82 79264108
Negative cardiac inotropic effect 11.52 9.92 4 480194 10 79264180
Antithyroid arthritis syndrome 11.52 9.92 4 480194 10 79264180
Brugada syndrome 11.52 9.92 24 480174 1214 79262976
Organising pneumonia 11.51 9.92 31 480167 10908 79253282
Amaurosis fugax 11.49 9.92 20 480178 883 79263307
Urinary retention 11.43 9.92 433 479765 56197 79207993
Eye haemorrhage 11.41 9.92 99 480099 9658 79254532
Electrocardiogram ST-T change 11.40 9.92 28 480170 1581 79262609
Pneumatosis intestinalis 11.40 9.92 13 480185 6384 79257806
Scleritis 11.38 9.92 6 480192 4350 79259840
Meningitis aseptic 11.38 9.92 15 480183 6913 79257277
Pneumonia cytomegaloviral 11.37 9.92 8 480190 4961 79259229
Paradoxical drug reaction 11.35 9.92 16 480182 7169 79257021
Electrocardiogram ST segment elevation 11.33 9.92 88 480110 8309 79255881
Scan gallium abnormal 11.33 9.92 5 480193 28 79264162
Cyanopsia 11.31 9.92 7 480191 85 79264105
Lupus-like syndrome 11.29 9.92 44 480154 13813 79250377
Blood cholinesterase decreased 11.28 9.92 11 480187 270 79263920
Hyperpyrexia 11.28 9.92 12 480186 6080 79258110
Psychomotor skills impaired 11.25 9.92 9 480189 5228 79258962
Poor peripheral circulation 11.24 9.92 48 480150 3635 79260555
Malignant neoplasm of eye 11.24 9.92 7 480191 86 79264104
Chromatopsia 11.24 9.92 17 480181 666 79263524
Coronary ostial stenosis 11.22 9.92 9 480189 169 79264021
Polymyositis 11.22 9.92 42 480156 2994 79261196
Complication of device insertion 11.21 9.92 13 480185 6337 79257853
Therapy cessation 11.20 9.92 301 479897 37261 79226929
Heart disease congenital 11.18 9.92 16 480182 596 79263594
Body temperature increased 11.18 9.92 194 480004 44226 79219964
Carcinoid tumour of the gastrointestinal tract 11.17 9.92 7 480191 87 79264103
Incision site pain 11.17 9.92 40 480158 2790 79261400
Activated partial thromboplastin time prolonged 11.17 9.92 133 480065 14095 79250095
Hypothyroidism 11.16 9.92 403 479795 51989 79212201
Galactorrhoea 11.15 9.92 4 480194 3642 79260548
Organ failure 11.13 9.92 51 480147 3982 79260208
Burning sensation 11.06 9.92 445 479753 58187 79206003
Hypertensive nephropathy 11.05 9.92 21 480177 993 79263197
Tricuspid valve sclerosis 11.04 9.92 5 480193 30 79264160
Psychomotor hyperactivity 11.03 9.92 58 480140 16791 79247399
Blood pressure diastolic abnormal 11.01 9.92 69 480129 19133 79245057
Lung opacity 10.98 9.92 9 480189 5165 79259025
Glomerular filtration rate abnormal 10.97 9.92 28 480170 1620 79262570
Oedema due to cardiac disease 10.95 9.92 6 480192 57 79264133
Lymphoma 10.93 9.92 61 480137 17399 79246791
Nail pitting 10.91 9.92 13 480185 403 79263787
Blood pressure orthostatic 10.90 9.92 7 480191 91 79264099
Stress cardiomyopathy 10.90 9.92 109 480089 11057 79253133
Chronic gastritis 10.90 9.92 51 480147 4017 79260173
Accelerated hypertension 10.89 9.92 17 480181 685 79263505
Somnolence 10.88 9.92 1266 478932 237715 79026475
Akathisia 10.86 9.92 42 480156 13217 79250973
Hypothermia 10.86 9.92 195 480003 22551 79241639
Chest discomfort 10.85 9.92 969 479229 137075 79127115
Neutropenic colitis 10.84 9.92 11 480187 5696 79258494
Altered state of consciousness 10.83 9.92 192 480006 43630 79220560
Splenic haemorrhage 10.81 9.92 17 480181 689 79263501
Osteonecrosis of jaw 10.81 9.92 189 480009 43037 79221153
Hypertensive urgency 10.80 9.92 15 480183 543 79263647
Gastric polyps 10.80 9.92 48 480150 3699 79260491
Sinus tachycardia 10.79 9.92 295 479903 36613 79227577
Optic neuritis 10.77 9.92 26 480172 9494 79254696
Blood pressure systolic decreased 10.75 9.92 108 480090 10968 79253222
Soft tissue haemorrhage 10.74 9.92 13 480185 410 79263780
Ulcer haemorrhage 10.73 9.92 66 480132 5772 79258418
Diffuse large B-cell lymphoma recurrent 10.69 9.92 6 480192 4201 79259989
Social avoidant behaviour 10.69 9.92 8 480190 4806 79259384
JC virus infection 10.66 9.92 5 480193 3876 79260314
Agitation 10.66 9.92 491 479707 99224 79164966
Cystic fibrosis 10.66 9.92 5 480193 3875 79260315
Gastric cyst 10.65 9.92 7 480191 95 79264095
Inhibitory drug interaction 10.62 9.92 54 480144 4399 79259791
Angiocardiogram 10.61 9.92 10 480188 235 79263955
Respiratory symptom 10.59 9.92 8 480190 4783 79259407
Coronary artery insufficiency 10.59 9.92 9 480189 184 79264006
Eosinophil count increased 10.58 9.92 60 480138 17045 79247145
Sputum discoloured 10.56 9.92 82 480116 21661 79242529
Pseudomonas infection 10.55 9.92 78 480120 20825 79243365
Blood bicarbonate abnormal 10.55 9.92 8 480190 138 79264052
Blood lactate dehydrogenase increased 10.53 9.92 169 480029 39001 79225189
Pyonephrosis 10.52 9.92 7 480191 97 79264093
Arterial occlusive disease 10.52 9.92 87 480111 8369 79255821
Intestinal angioedema 10.51 9.92 19 480179 864 79263326
Euphoric mood 10.51 9.92 19 480179 7707 79256483
Polyomavirus-associated nephropathy 10.51 9.92 11 480187 5616 79258574
Hyperhidrosis 10.51 9.92 1054 479144 150438 79113752
Tenosynovitis 10.49 9.92 53 480145 15501 79248689
Increased viscosity of bronchial secretion 10.47 9.92 15 480183 559 79263631
Preternatural anus 10.46 9.92 7 480191 98 79264092
Cardiac fibrillation 10.44 9.92 20 480178 951 79263239
Blood immunoglobulin E increased 10.43 9.92 12 480186 5870 79258320
Rhinovirus infection 10.43 9.92 20 480178 7933 79256257
Metabolic acidosis 10.40 9.92 602 479596 81927 79182263
Skin necrosis 10.37 9.92 65 480133 18022 79246168
Psychotic disorder 10.36 9.92 181 480017 41221 79222969
Mesenteric arterial occlusion 10.34 9.92 10 480188 243 79263947
Femoral pulse decreased 10.33 9.92 4 480194 15 79264175
Silent myocardial infarction 10.32 9.92 17 480181 717 79263473
Myxoedema 10.31 9.92 8 480190 143 79264047
Thrombosis in device 10.30 9.92 62 480136 5380 79258810
Pacemaker syndrome 10.29 9.92 3 480195 3 79264187
Non-small cell lung cancer stage IIIA 10.29 9.92 3 480195 3 79264187
Drug withdrawal syndrome 10.29 9.92 147 480051 34571 79229619
Total cholesterol/HDL ratio decreased 10.29 9.92 5 480193 36 79264154
Diffuse mesangial sclerosis 10.28 9.92 6 480192 65 79264125
Depressed mood 10.28 9.92 218 479980 48262 79215928
Urosepsis 10.24 9.92 220 479978 26275 79237915
Bladder neck obstruction 10.23 9.92 7 480191 102 79264088
Malignant hypertension 10.22 9.92 27 480171 1595 79262595
Bronchial secretion retention 10.22 9.92 6 480192 4098 79260092
Hyperreflexia 10.22 9.92 22 480176 8363 79255827
Shock hypoglycaemic 10.21 9.92 10 480188 247 79263943
N-terminal prohormone brain natriuretic peptide increased 10.20 9.92 56 480142 4699 79259491
Chemical burn of oral cavity 10.20 9.92 6 480192 66 79264124
Visual field defect 10.18 9.92 91 480107 8954 79255236
Splenic rupture 10.17 9.92 35 480163 2394 79261796
Blood cholesterol decreased 10.15 9.92 28 480170 1697 79262493
Swelling face 10.15 9.92 339 479859 70873 79193317
Dysuria 10.15 9.92 389 479809 50562 79213628
Hospitalisation 10.14 9.92 678 479520 93558 79170632
Urinary tract obstruction 10.14 9.92 56 480142 4709 79259481
Chest wall haematoma 10.12 9.92 13 480185 436 79263754
Mood swings 10.12 9.92 74 480124 19806 79244384
Hepatosplenomegaly 10.11 9.92 13 480185 6056 79258134
Nodular rash 10.06 9.92 11 480187 310 79263880
Coarctation of the aorta 10.05 9.92 6 480192 68 79264122
Electrocardiogram T wave inversion 10.04 9.92 61 480137 5311 79258879
Enthesopathy 10.01 9.92 36 480162 11572 79252618
Ocular icterus 10.00 9.92 62 480136 5438 79258752
Gangrene 9.99 9.92 90 480108 8874 79255316
Nasal polyps 9.98 9.92 18 480180 7309 79256881
Lacunar stroke 9.97 9.92 12 480186 376 79263814
Non-compaction cardiomyopathy 9.95 9.92 5 480193 39 79264151
Glomerulonephritis rapidly progressive 9.95 9.92 27 480171 1621 79262569
Urea renal clearance decreased 9.94 9.92 4 480194 17 79264173
Acute graft versus host disease in intestine 9.93 9.92 6 480192 4035 79260155
Paronychia 9.92 9.92 20 480178 7788 79256402
Haematocrit decreased 9.92 9.92 458 479740 60854 79203336

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neonatal respiratory failure 49.94 28.07 34 977 251 88530

Pharmacologic Action:

SourceCodeDescription
ATC C07AB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07BB52 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07CB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07FB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013565 Sympatholytics
CHEBI has role CHEBI:35530 beta-adrenergic blockers
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Angina pectoris indication 194828000
Acute coronary syndrome indication 394659003
Myocardial Reinfarction Prevention indication
Supraventricular tachycardia off-label use 6456007
Ventricular tachycardia off-label use 25569003
Atrial fibrillation off-label use 49436004 DOID:0060224
Multifocal atrial tachycardia off-label use 49982000
Paroxysmal supraventricular tachycardia off-label use 67198005
Thyrotoxicosis off-label use 90739004 DOID:7997
Paroxysmal atrial tachycardia off-label use 195069001
Ectopic atrial tachycardia off-label use 233892002
Mitral valve prolapse off-label use 409712001
Diastolic heart failure off-label use 418304008 DOID:9775
Migraine Prevention off-label use
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Pheochromocytoma Adjunct Therapy off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Myasthenia gravis contraindication 91637004 DOID:437
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Azotemia contraindication 445009001
Acute exacerbation of asthma contraindication 708038006
First Degree Atrioventricular Heart Block contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.60 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.30 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.79 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.83 CHEMBL
Adrenergic receptor beta GPCR IC50 6.30 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 7.31 CHEMBL

External reference:

IDSource
D00601 KEGG_DRUG
80274-67-5 SECONDARY_CAS_RN
98418-47-4 SECONDARY_CAS_RN
56392-17-7 SECONDARY_CAS_RN
4018393 VANDF
4019836 VANDF
4020875 VANDF
C0025859 UMLSCUI
CHEBI:6904 CHEBI
CHEMBL13 ChEMBL_ID
CHEMBL3989566 ChEMBL_ID
CHEMBL1200337 ChEMBL_ID
CHEMBL2356097 ChEMBL_ID
DB00264 DRUGBANK_ID
CHEMBL2062335 ChEMBL_ID
D008790 MESH_DESCRIPTOR_UI
4171 PUBCHEM_CID
553 IUPHAR_LIGAND_ID
3471 INN_ID
GEB06NHM23 UNII
102313 RXNORM
1073 MMSL
5102 MMSL
5103 MMSL
d00134 MMSL
001853 NDDF
003627 NDDF
003628 NDDF
004135 NDDF
372826007 SNOMEDCT_US
412432007 SNOMEDCT_US
7092007 SNOMEDCT_US
72770009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9660 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9873 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0018 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0018 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0018 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0032 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0032 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0032 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0047 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0047 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0047 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0424 TABLET 50 mg ORAL ANDA 35 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0424 TABLET 50 mg ORAL ANDA 35 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0434 TABLET 100 mg ORAL ANDA 35 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0434 TABLET 100 mg ORAL ANDA 35 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0445 TABLET 100 mg ORAL ANDA 35 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0445 TABLET 100 mg ORAL ANDA 35 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4593 TABLET, FILM COATED 37.50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4593 TABLET, FILM COATED 37.50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4593 TABLET, FILM COATED 37.50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4594 TABLET, FILM COATED 75 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4594 TABLET, FILM COATED 75 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4594 TABLET, FILM COATED 75 mg ORAL ANDA 23 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4595 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4595 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4595 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4595 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4596 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4596 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4596 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL ANDA 30 sections