metoprolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 1786 51384-51-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metoprolol fumarate
  • metoprolol
  • metoprolol succinate
  • beatrolol
  • metoprolol tartrate
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
  • Molecular weight: 267.37
  • Formula: C15H25NO3
  • CLOGP: 1.49
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 50.72
  • ALOGS: -2.82
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1000 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 24.95 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 13 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.88 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1978 FDA US PHARMS HOLDINGS I

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 889.78 9.79 1786 257450 95742 46331084
Cardiac failure congestive 679.48 9.79 1544 257692 90206 46336620
Atrial fibrillation 639.95 9.79 1625 257611 101965 46324861
Coronary artery disease 483.65 9.79 754 258482 32998 46393828
Rheumatoid arthritis 450.18 9.79 403 258833 239812 46187014
Drug ineffective 402.65 9.79 2172 257064 675666 45751160
Bradycardia 394.59 9.79 1026 258210 65272 46361554
Acute myocardial infarction 367.06 9.79 646 258590 31278 46395548
Cerebrovascular accident 245.06 9.79 1161 258075 99878 46326948
Completed suicide 233.13 9.79 1497 257739 144423 46282403
Contraindicated product administered 220.33 9.79 84 259152 79863 46346963
Synovitis 213.81 9.79 40 259196 61035 46365791
Pemphigus 197.07 9.79 14 259222 45260 46381566
Hypotension 193.99 9.79 2059 257177 230530 46196296
Treatment failure 186.58 9.79 146 259090 92941 46333885
Drug intolerance 184.41 9.79 334 258902 146715 46280111
Systemic lupus erythematosus 162.85 9.79 79 259157 65101 46361725
Off label use 159.28 9.79 1347 257889 378494 46048332
Product prescribing error 158.95 9.79 347 258889 19700 46407126
Coronary artery bypass 157.28 9.79 121 259115 2324 46424502
Hand deformity 149.59 9.79 11 259225 34563 46392263
Infusion related reaction 145.51 9.79 210 259026 100998 46325828
Dizziness 132.96 9.79 2639 256597 337775 46089051
Cardiogenic shock 132.63 9.79 286 258950 16098 46410728
Syncope 132.48 9.79 1016 258220 103787 46323039
Abortion spontaneous 130.37 9.79 40 259196 43606 46383220
General physical health deterioration 129.32 9.79 1091 258145 114678 46312148
Angina pectoris 126.31 9.79 381 258855 26394 46400432
Gastrointestinal haemorrhage 121.07 9.79 790 258446 76583 46350243
Coronary arterial stent insertion 120.96 9.79 111 259125 2742 46424084
Lower respiratory tract infection 112.14 9.79 85 259151 55004 46371822
Drug hypersensitivity 111.54 9.79 844 258392 242981 46183845
Sinus bradycardia 110.90 9.79 240 258996 13542 46413284
Glossodynia 110.50 9.79 54 259182 44319 46382507
Joint swelling 108.64 9.79 513 258723 165560 46261266
Angina unstable 107.19 9.79 168 259068 7380 46419446
Cardiac disorder 105.51 9.79 503 258733 43355 46383471
Pyrexia 104.63 9.79 1338 257898 347464 46079362
Palpitations 104.39 9.79 894 258342 94365 46332461
Exposure during pregnancy 99.07 9.79 291 258945 107921 46318905
Arrhythmia 98.36 9.79 419 258817 34422 46392404
Febrile neutropenia 98.32 9.79 239 258997 94388 46332438
Therapeutic product effect decreased 97.01 9.79 195 259041 82406 46344420
Rheumatoid factor positive 96.25 9.79 4 259232 20457 46406369
Dyspnoea 95.85 9.79 3630 255606 511918 45914908
Fall 95.30 9.79 2446 256790 326651 46100175
International normalised ratio increased 94.76 9.79 512 258724 46371 46380455
Hypertension 92.83 9.79 1569 257667 194787 46232039
Drug abuse 92.66 9.79 130 259106 63278 46363548
Rash 91.48 9.79 1411 257825 355101 46071725
Arthropathy 89.52 9.79 212 259024 84488 46342338
Maternal exposure during pregnancy 88.72 9.79 283 258953 102266 46324560
Hypersensitivity 85.53 9.79 487 258749 149834 46276992
Ventricular tachycardia 85.32 9.79 247 258989 16720 46410106
Neutropenia 85.27 9.79 457 258779 142747 46284079
Pregnancy 84.48 9.79 23 259213 27114 46399712
Device expulsion 79.14 9.79 27 259209 27515 46399311
Pain 79.05 9.79 2031 257205 474917 45951909
C-reactive protein abnormal 78.69 9.79 12 259224 21258 46405568
Blood pressure inadequately controlled 78.34 9.79 109 259127 4297 46422529
Renal failure 75.02 9.79 962 258274 112632 46314194
Asthma 72.13 9.79 263 258973 91279 46335547
Blood pressure increased 71.13 9.79 1042 258194 125624 46301202
Arthralgia 70.81 9.79 1515 257721 363088 46063738
Interstitial lung disease 70.77 9.79 119 259117 53830 46372996
Haematochezia 68.82 9.79 399 258837 37094 46389732
Blood loss anaemia 67.69 9.79 148 259088 8409 46418417
Medication error 63.42 9.79 339 258897 30572 46396254
Asthenia 62.86 9.79 2212 257024 308863 46117963
Therapeutic drug monitoring analysis not performed 62.29 9.79 37 259199 453 46426373
Suicidal ideation 62.09 9.79 138 259098 56244 46370582
Nodal rhythm 61.52 9.79 61 259175 1664 46425162
Product monitoring error 61.48 9.79 65 259171 1916 46424910
Pericarditis 61.28 9.79 28 259208 23899 46402927
Dehydration 59.78 9.79 1230 258006 158310 46268516
Oedema peripheral 59.42 9.79 1230 258006 158476 46268350
Product use issue 59.14 9.79 297 258939 94347 46332479
Hypertensive crisis 58.89 9.79 188 259048 13427 46413399
Cardiac failure 57.91 9.79 689 258547 79259 46347567
Chest pain 57.65 9.79 1333 257903 174991 46251835
Cardiac arrest 57.33 9.79 760 258476 89639 46337187
Hepatic function abnormal 56.06 9.79 65 259171 34356 46392470
Drug resistance 55.44 9.79 14 259222 17354 46409472
Swelling 54.95 9.79 435 258801 124076 46302750
Pulmonary oedema 54.05 9.79 476 258760 50629 46376197
Atrial flutter 53.76 9.79 141 259095 9007 46417819
Hypertensive emergency 53.64 9.79 55 259181 1563 46425263
Pulmonary renal syndrome 53.52 9.79 31 259205 361 46426465
Drug reaction with eosinophilia and systemic symptoms 53.51 9.79 51 259185 29497 46397329
Headache 53.19 9.79 2145 257091 476207 45950619
Anti-neutrophil cytoplasmic antibody positive vasculitis 52.23 9.79 59 259177 1876 46424950
Coronary artery occlusion 50.84 9.79 128 259108 7974 46418852
Product substitution issue 50.61 9.79 191 259045 14840 46411986
Blood creatinine increased 49.98 9.79 646 258590 75757 46351069
Haemoglobin decreased 48.89 9.79 996 258240 127953 46298873
Infection 47.91 9.79 492 258744 133100 46293726
Hepatocellular injury 47.80 9.79 56 259180 29466 46397360
C-reactive protein increased 47.69 9.79 166 259070 58424 46368402
Erythema 47.20 9.79 536 258700 142284 46284542
Myocardial ischaemia 44.59 9.79 164 259072 12585 46414241
Product use in unapproved indication 44.31 9.79 306 258930 89967 46336859
Lower gastrointestinal haemorrhage 44.22 9.79 114 259122 7206 46419620
Ventricular fibrillation 43.72 9.79 152 259084 11344 46415482
Orthostatic intolerance 43.38 9.79 42 259194 1112 46425714
Injection site pain 42.92 9.79 384 258852 106768 46320058
Chronic kidney disease 42.87 9.79 380 258856 40491 46386335
Abortion induced 42.35 9.79 4 259232 10256 46416570
Anaphylactic reaction 40.90 9.79 154 259082 52958 46373868
BRASH syndrome 40.76 9.79 17 259219 89 46426737
Infective pulmonary exacerbation of cystic fibrosis 40.20 9.79 6 259230 10801 46416025
Mental status changes 39.88 9.79 354 258882 37734 46389092
Sinusitis 38.68 9.79 498 258738 129270 46297556
Toxicity to various agents 38.37 9.79 1488 257748 210278 46216548
Hepatic enzyme increased 38.31 9.79 281 258955 81506 46345320
Bone erosion 38.15 9.79 4 259232 9439 46417387
Unresponsive to stimuli 37.89 9.79 307 258929 31867 46394959
Peripheral arterial occlusive disease 36.89 9.79 71 259165 3681 46423145
Duodenal ulcer perforation 35.95 9.79 3 259233 8499 46418327
Pulmonary hypertension 35.88 9.79 331 258905 35662 46391164
Intestinal malrotation 35.84 9.79 23 259213 326 46426500
Pneumocystis jirovecii pneumonia 35.82 9.79 20 259216 15228 46411598
Congenital hydronephrosis 35.18 9.79 24 259212 379 46426447
Sopor 35.00 9.79 35 259201 19793 46407033
Heart rate irregular 34.86 9.79 199 259037 18392 46408434
Intentional self-injury 34.84 9.79 50 259186 24116 46402710
Full blood count decreased 34.84 9.79 227 259009 21984 46404842
Transient ischaemic attack 34.81 9.79 321 258915 34582 46392244
Inflammation 34.67 9.79 146 259090 48635 46378191
Red blood cell sedimentation rate increased 34.36 9.79 46 259190 22843 46403983
Drug interaction 34.21 9.79 1416 257820 201678 46225148
Atrioventricular block 34.09 9.79 99 259137 6712 46420114
Alopecia 34.05 9.79 666 258570 161748 46265078
Migraine 34.05 9.79 238 258998 69788 46357038
Heart rate increased 33.94 9.79 594 258642 74197 46352629
Nephrogenic systemic fibrosis 33.80 9.79 79 259157 4693 46422133
Acute kidney injury 33.51 9.79 1616 257620 234239 46192587
Heart rate decreased 33.29 9.79 295 258941 31428 46395398
Bone marrow failure 33.17 9.79 72 259164 29597 46397229
Decorticate posture 32.77 9.79 22 259214 338 46426488
Haemophagocytic lymphohistiocytosis 32.53 9.79 4 259232 8338 46418488
Myocardial depression 32.37 9.79 25 259211 483 46426343
Therapeutic product effect incomplete 32.21 9.79 278 258958 77875 46348951
Congenital aortic valve stenosis 32.15 9.79 13 259223 62 46426764
Cardiac output decreased 32.06 9.79 32 259204 880 46425946
Vascular graft 32.00 9.79 30 259206 762 46426064
Suspected suicide 31.75 9.79 76 259160 4585 46422241
Renal injury 31.10 9.79 120 259116 9421 46417405
Ischaemic stroke 30.70 9.79 178 259058 16544 46410282
Injection site erythema 30.56 9.79 265 258971 74162 46352664
Coronary artery stenosis 30.14 9.79 75 259161 4638 46422188
Anaemia 29.98 9.79 1721 257515 254058 46172768
Injection site reaction 29.96 9.79 150 259086 47699 46379127
Lactic acidosis 29.95 9.79 304 258932 33605 46393221
Tachyarrhythmia 29.93 9.79 74 259162 4558 46422268
Cytomegalovirus infection 29.82 9.79 34 259202 18110 46408716
Acute coronary syndrome 29.79 9.79 124 259112 10080 46416746
Thrombosis 29.78 9.79 457 258779 55612 46371214
Device dislocation 29.60 9.79 47 259189 21755 46405071
Atrioventricular block complete 29.14 9.79 101 259135 7526 46419300
Death 28.97 9.79 2200 257036 333348 46093478
Supraventricular tachycardia 28.91 9.79 148 259088 13122 46413704
Hypothermia 28.76 9.79 139 259097 12044 46414782
Lymphocyte count decreased 28.68 9.79 62 259174 25527 46401299
Internal haemorrhage 28.60 9.79 71 259165 4384 46422442
Mitral valve incompetence 28.56 9.79 191 259045 18661 46408165
Cardiac failure acute 28.32 9.79 104 259132 7974 46418852
Drug eruption 28.01 9.79 47 259189 21282 46405544
Neutrophil count decreased 27.85 9.79 135 259101 43291 46383535
Neutropenic sepsis 27.76 9.79 17 259219 12307 46414519
Skin induration 27.69 9.79 55 259181 2919 46423907
Hip arthroplasty 27.60 9.79 36 259200 18076 46408750
Conjoined twins 27.58 9.79 18 259218 263 46426563
Acute generalised exanthematous pustulosis 27.40 9.79 9 259227 9396 46417430
Urticaria 27.33 9.79 475 258761 117417 46309409
Abdominal discomfort 27.27 9.79 635 258601 150530 46276296
Mucosal inflammation 26.87 9.79 118 259118 38858 46387968
Presyncope 26.49 9.79 229 259007 24225 46402601
Device difficult to use 26.43 9.79 6 259230 7998 46418828
Hyperkalaemia 26.43 9.79 412 258824 50297 46376529
Musculoskeletal stiffness 26.34 9.79 384 258852 97609 46329217
Device capturing issue 26.32 9.79 10 259226 39 46426787
Acute respiratory failure 26.10 9.79 262 258974 28876 46397950
Ventricular extrasystoles 25.95 9.79 126 259110 10937 46415889
Renal impairment neonatal 25.58 9.79 8 259228 14 46426812
Acute left ventricular failure 25.53 9.79 27 259209 796 46426030
Allergic reaction to excipient 25.51 9.79 18 259218 301 46426525
Condition aggravated 25.40 9.79 1107 258129 243945 46182881
Helicobacter infection 25.33 9.79 17 259219 11719 46415107
Schizophrenia 25.32 9.79 8 259228 8560 46418266
Electrocardiogram T wave abnormal 25.06 9.79 46 259190 2300 46424526
Cholestasis 24.82 9.79 72 259164 26821 46400005
Rash maculo-papular 24.73 9.79 76 259160 27798 46399028
Dystonia 24.71 9.79 16 259220 11241 46415585
Atrioventricular block first degree 24.58 9.79 83 259153 6103 46420723
Listless 24.44 9.79 42 259194 1993 46424833
Cerebral haemorrhage 24.41 9.79 253 258983 28118 46398708
Colitis ulcerative 24.29 9.79 38 259198 17694 46409132
Arterial haemorrhage 24.06 9.79 38 259198 1680 46425146
Diverticulum intestinal haemorrhagic 23.99 9.79 32 259204 1211 46425615
Renal impairment 23.87 9.79 561 258675 73811 46353015
Product administration error 23.83 9.79 189 259047 19492 46407334
Cardiac pacemaker insertion 23.80 9.79 59 259177 3640 46423186
Bradyarrhythmia 23.57 9.79 41 259195 1965 46424861
Gastrointestinal tract mucosal pigmentation 23.49 9.79 22 259214 558 46426268
Amenorrhoea 23.42 9.79 10 259226 8885 46417941
Phaeochromocytoma crisis 23.39 9.79 14 259222 174 46426652
Nodal arrhythmia 23.20 9.79 32 259204 1251 46425575
Atrial tachycardia 23.20 9.79 42 259194 2078 46424748
Hypertensive heart disease 23.19 9.79 47 259189 2531 46424295
Hepatitis 23.15 9.79 96 259140 32119 46394707
Vitello-intestinal duct remnant 22.94 9.79 9 259227 39 46426787
Arteriosclerosis 22.94 9.79 111 259125 9622 46417204
Gout 22.92 9.79 124 259112 11232 46415594
Ischaemic cardiomyopathy 22.79 9.79 47 259189 2563 46424263
Lymphopenia 22.69 9.79 31 259205 15262 46411564
Acne 22.54 9.79 48 259188 19871 46406955
Coma 22.53 9.79 211 259025 58138 46368688
Intraventricular haemorrhage 22.47 9.79 39 259197 1866 46424960
Progressive multifocal leukoencephalopathy 22.46 9.79 18 259218 11328 46415498
Aortic valve stenosis 22.44 9.79 52 259184 3072 46423754
Loss of employment 22.22 9.79 31 259205 1225 46425601
Non-cardiogenic pulmonary oedema 22.09 9.79 21 259215 543 46426283
Torsade de pointes 22.07 9.79 129 259107 12025 46414801
Liver disorder 22.06 9.79 119 259117 37127 46389699
Troponin increased 22.05 9.79 94 259142 7722 46419104
Labile hypertension 22.00 9.79 20 259216 488 46426338
Hip fracture 21.99 9.79 235 259001 26321 46400505
Loss of personal independence in daily activities 21.99 9.79 207 259029 56976 46369850
Congenital choroid plexus cyst 21.96 9.79 16 259220 282 46426544
Vascular resistance pulmonary decreased 21.59 9.79 10 259226 70 46426756
Vomiting 21.52 9.79 2194 257042 450600 45976226
Diarrhoea 21.43 9.79 3477 255759 556125 45870701
Ventricular arrhythmia 21.42 9.79 54 259182 3367 46423459
Product solubility abnormal 21.35 9.79 25 259211 827 46425999
Myxoedema coma 21.31 9.79 18 259218 397 46426429
CD30 expression 21.29 9.79 8 259228 30 46426796
Hyperthermia 21.12 9.79 9 259227 8005 46418821
Ventricular hypokinesia 21.11 9.79 60 259176 4018 46422808
Haematoma 21.04 9.79 270 258966 31602 46395224
Hypomagnesaemia 21.01 9.79 202 259034 22008 46404818
Heparin-induced thrombocytopenia 20.96 9.79 62 259174 4247 46422579
Rheumatoid nodule 20.94 9.79 12 259224 9008 46417818
Atrial septal defect 20.93 9.79 80 259156 6252 46420574
Chloropsia 20.89 9.79 8 259228 32 46426794
Congenital bladder anomaly 20.64 9.79 13 259223 178 46426648
Epistaxis 20.62 9.79 485 258751 63820 46363006
Haemarthrosis 20.60 9.79 49 259187 2944 46423882
Body height decreased 20.58 9.79 107 259129 9545 46417281
Rectourethral fistula 20.52 9.79 8 259228 34 46426792
Urachal abnormality 20.39 9.79 13 259223 182 46426644
Osmolar gap increased 20.31 9.79 7 259229 19 46426807
Subchondral insufficiency fracture 20.31 9.79 9 259227 56 46426770
Atrial thrombosis 20.31 9.79 32 259204 1412 46425414
Therapeutic response decreased 20.31 9.79 148 259088 42997 46383829
Cerebrospinal fluid retention 20.25 9.79 10 259226 82 46426744
Bicuspid aortic valve 20.17 9.79 11 259225 113 46426713
Tendonitis 20.13 9.79 30 259206 14247 46412579
Seizure 19.99 9.79 525 258711 122529 46304297
Anuria 19.90 9.79 120 259116 11311 46415515
Glomerular filtration rate decreased 19.88 9.79 122 259114 11572 46415254
Sudden cardiac death 19.73 9.79 40 259196 2155 46424671
Fryns syndrome 19.55 9.79 9 259227 62 46426764
Blue toe syndrome 19.48 9.79 16 259220 339 46426487
Mood swings 19.38 9.79 38 259198 16214 46410612
Persistent cloaca 19.35 9.79 13 259223 200 46426626
Mouth ulceration 19.25 9.79 80 259156 26752 46400074
Cardiac ablation 19.25 9.79 29 259207 1230 46425596
Alanine aminotransferase increased 19.04 9.79 361 258875 88090 46338736
Dyspnoea exertional 18.89 9.79 388 258848 49901 46376925
Splenic rupture 18.74 9.79 28 259208 1179 46425647
Agranulocytosis 18.63 9.79 62 259174 22123 46404703
Aortic valve incompetence 18.58 9.79 74 259162 5896 46420930
Pharyngitis 18.57 9.79 44 259192 17539 46409287
Wrong product administered 18.51 9.79 71 259165 5559 46421267
Embolic cerebral infarction 18.42 9.79 18 259218 482 46426344
Angioedema 18.40 9.79 314 258922 39028 46387798
Embolic stroke 18.32 9.79 53 259183 3586 46423240
Patent ductus arteriosus 18.25 9.79 55 259181 3807 46423019
Neurotoxicity 18.22 9.79 30 259206 13687 46413139
Cardiomegaly 18.05 9.79 162 259074 17320 46409506
Device stimulation issue 17.91 9.79 9 259227 77 46426749
Malignant polyp 17.89 9.79 12 259224 184 46426642
Atrioventricular block second degree 17.85 9.79 54 259182 3745 46423081
Ultrasound kidney abnormal 17.72 9.79 7 259229 31 46426795
Hepatotoxicity 17.67 9.79 75 259161 24934 46401892
Ovarian cyst 17.62 9.79 32 259204 14055 46412771
Malignant neoplasm progression 17.59 9.79 254 258982 64672 46362154
End stage renal disease 17.55 9.79 72 259164 5814 46421012
Epilepsy 17.52 9.79 70 259166 23668 46403158
Drug therapeutic incompatibility 17.51 9.79 8 259228 54 46426772
Toxic skin eruption 17.49 9.79 26 259210 12361 46414465
Neutrophil function disorder 17.49 9.79 6 259230 16 46426810
Metastases to bone 17.46 9.79 45 259191 17431 46409395
Blood pressure abnormal 17.45 9.79 122 259114 12095 46414731
Live birth 17.37 9.79 19 259217 10311 46416515
Left-to-right cardiac shunt 17.22 9.79 10 259226 117 46426709
Blood potassium decreased 17.15 9.79 302 258934 37761 46389065
Mobility decreased 17.14 9.79 235 259001 60359 46366467
Tuberculosis 17.13 9.79 19 259217 10246 46416580
Product dose omission issue 17.12 9.79 1120 258116 167400 46259426
Immunodeficiency 17.10 9.79 29 259207 13077 46413749
Post procedural haemorrhage 17.01 9.79 84 259152 7342 46419484
Labelled drug-drug interaction medication error 16.99 9.79 97 259139 8964 46417862
Serotonin syndrome 16.89 9.79 73 259163 24147 46402679
Coronary artery dissection 16.88 9.79 20 259216 670 46426156
Cardioversion 16.86 9.79 26 259210 1126 46425700
Negative cardiac inotropic effect 16.80 9.79 4 259232 0 46426826
Adrenalectomy 16.80 9.79 4 259232 0 46426826
Pulmonary tuberculosis 16.76 9.79 3 259233 4728 46422098
Cardioactive drug level increased 16.73 9.79 36 259200 2023 46424803
Deep vein thrombosis 16.72 9.79 570 258666 79203 46347623
Hyperammonaemia 16.69 9.79 3 259233 4713 46422113
Abdominal pain 16.68 9.79 1077 258159 228954 46197872
Fluid retention 16.67 9.79 386 258850 50660 46376166
Congenital nail disorder 16.63 9.79 9 259227 91 46426735
Bundle branch block left 16.56 9.79 75 259161 6324 46420502
Diverticulum intestinal 16.54 9.79 72 259164 5969 46420857
Coagulopathy 16.40 9.79 166 259070 18333 46408493
Injection site swelling 16.36 9.79 144 259092 40183 46386643
Eructation 16.34 9.79 82 259154 7213 46419613
Arteriovenous fistula occlusion 16.34 9.79 14 259222 315 46426511
Blood glucose increased 16.23 9.79 519 258717 71494 46355332
Osteonecrosis of jaw 16.19 9.79 118 259118 34284 46392542
Congenital acrochordon 16.16 9.79 8 259228 66 46426760
Sinus arrest 16.10 9.79 32 259204 1699 46425127
Septic shock 15.85 9.79 226 259010 57667 46369159
Cardiovascular disorder 15.85 9.79 119 259117 12068 46414758
Neonatal respiratory failure 15.84 9.79 11 259225 179 46426647
Bronchiectasis 15.81 9.79 17 259219 9299 46417527
Immune reconstitution inflammatory syndrome 15.79 9.79 6 259230 5719 46421107
Photophobia 15.68 9.79 36 259200 14508 46412318
Pathogen resistance 15.66 9.79 7 259229 6053 46420773
Pregnancy with contraceptive device 15.64 9.79 3 259233 4500 46422326
Cardiomyopathy 15.61 9.79 147 259089 15926 46410900
Ageusia 15.48 9.79 113 259123 11359 46415467
Gastrointestinal disorder 15.47 9.79 235 259001 59341 46367485
Haematuria 15.46 9.79 222 259014 26636 46400190
Traumatic haemorrhage 15.40 9.79 15 259221 400 46426426
Skin hypertrophy 15.36 9.79 45 259191 3066 46423760
Disseminated intravascular coagulation 15.36 9.79 54 259182 18951 46407875
Leukopenia 15.31 9.79 277 258959 68066 46358760
Orthopnoea 15.28 9.79 69 259167 5811 46421015
Eosinophilia 15.26 9.79 55 259181 19162 46407664
Pruritus 15.21 9.79 1149 258087 241203 46185623
Respiratory disorder 15.20 9.79 89 259147 27211 46399615
Blood pressure decreased 15.06 9.79 420 258816 56739 46370087
Congenital diaphragmatic hernia 15.00 9.79 11 259225 196 46426630
Tachycardia induced cardiomyopathy 14.99 9.79 7 259229 50 46426776
Body temperature increased 14.96 9.79 79 259157 24782 46402044
Renal dysplasia 14.93 9.79 10 259226 153 46426673
Urogenital haemorrhage 14.93 9.79 10 259226 153 46426673
International normalised ratio decreased 14.85 9.79 57 259179 4463 46422363
Sinus node dysfunction 14.85 9.79 55 259181 4234 46422592
Hypocapnia 14.83 9.79 14 259222 359 46426467
Injection site pruritus 14.80 9.79 145 259091 39598 46387228
Pleural effusion 14.78 9.79 582 258654 82370 46344456
Optic neuritis 14.76 9.79 10 259226 6861 46419965
Alpha hydroxybutyrate dehydrogenase increased 14.66 9.79 5 259231 13 46426813
Palmar-plantar erythrodysaesthesia syndrome 14.66 9.79 61 259175 20390 46406436
Femur fracture 14.62 9.79 133 259103 36864 46389962
Enterocolitis 14.62 9.79 8 259228 6160 46420666
Cardiac valve abscess 14.57 9.79 4 259232 3 46426823
Ischaemic hepatitis 14.56 9.79 34 259202 2019 46424807
Urinary tract infection 14.54 9.79 1416 257820 218850 46207976
Electrocardiogram QRS complex shortened 14.54 9.79 14 259222 368 46426458
Arteriosclerosis coronary artery 14.44 9.79 86 259150 8070 46418756
Oral herpes 14.42 9.79 57 259179 19333 46407493
Epstein-Barr virus infection 14.41 9.79 10 259226 6774 46420052
Pulseless electrical activity 14.29 9.79 78 259158 7089 46419737
Poor venous access 14.28 9.79 15 259221 8293 46418533
Hypovolaemia 14.27 9.79 99 259137 9789 46417037
Drug level increased 14.26 9.79 161 259075 18280 46408546
Aortic valve disease 14.26 9.79 22 259214 953 46425873
Aortic stenosis 14.19 9.79 55 259181 4327 46422499
Lymphatic fistula 14.18 9.79 21 259215 877 46425949
Mitral valve sclerosis 14.18 9.79 9 259227 125 46426701
Thrombin time prolonged 14.12 9.79 8 259228 89 46426737
Stent malfunction 14.12 9.79 7 259229 58 46426768
Panniculitis 14.11 9.79 7 259229 5697 46421129
Femoral hernia incarcerated 13.99 9.79 21 259215 888 46425938
Poisoning deliberate 13.98 9.79 14 259222 7912 46418914
Heart rate abnormal 13.95 9.79 46 259190 3341 46423485
Pallor 13.95 9.79 193 259043 22973 46403853
Complication of device insertion 13.94 9.79 5 259231 4939 46421887
Electrocardiogram T wave inversion 13.82 9.79 47 259189 3469 46423357
Calciphylaxis 13.82 9.79 38 259198 2497 46424329
Uterine perforation 13.80 9.79 12 259224 7255 46419571
Haemorrhagic erosive gastritis 13.78 9.79 12 259224 276 46426550
Pancreatic steatosis 13.76 9.79 22 259214 983 46425843
Lung disorder 13.71 9.79 164 259072 43140 46383686
Graft versus host disease 13.61 9.79 10 259226 6578 46420248
Tooth erosion 13.61 9.79 15 259221 464 46426362
Pulmonary hypoplasia 13.61 9.79 12 259224 281 46426545
Body tinea 13.54 9.79 21 259215 914 46425912
Respiratory tract infection 13.54 9.79 104 259132 29868 46396958
Stent placement 13.51 9.79 47 259189 3509 46423317
Aortic aneurysm 13.50 9.79 46 259190 3398 46423428
Bronchopulmonary aspergillosis 13.50 9.79 13 259223 7483 46419343
Oesophagitis chemical 13.47 9.79 5 259231 18 46426808
Subarachnoid haemorrhage 13.44 9.79 107 259129 11046 46415780
Arrhythmia neonatal 13.44 9.79 7 259229 65 46426761
Pseudolymphoma 13.42 9.79 17 259219 611 46426215
Menstruation irregular 13.42 9.79 10 259226 6529 46420297
Lymphadenopathy 13.40 9.79 120 259116 33368 46393458
Myocardial necrosis marker increased 13.32 9.79 28 259208 1548 46425278
Extrasystoles 13.31 9.79 58 259178 4811 46422015
Disease recurrence 13.30 9.79 55 259181 18416 46408410
Drug dependence 13.26 9.79 61 259175 19840 46406986
Oropharyngeal pain 13.24 9.79 312 258924 73856 46352970
Blood urea increased 13.21 9.79 206 259030 25146 46401680
Haemorrhage intracranial 13.18 9.79 118 259118 12606 46414220
Cerebral ventricular rupture 13.13 9.79 10 259226 189 46426637
Breast cancer 13.06 9.79 176 259060 45342 46381484
Device breakage 13.06 9.79 21 259215 9671 46417155
QRS axis abnormal 13 9.79 22 259214 1031 46425795
Hypogammaglobulinaemia 12.96 9.79 7 259229 5431 46421395
Ankylosing spondylitis 12.95 9.79 11 259225 6726 46420100
Renal function test abnormal 12.94 9.79 39 259197 2700 46424126
Gouty arthritis 12.91 9.79 15 259221 492 46426334
Gastrointestinal toxicity 12.88 9.79 4 259232 4327 46422499
Wound 12.83 9.79 164 259072 42638 46384188
Generalised tonic-clonic seizure 12.78 9.79 93 259143 27029 46399797
Fibromyalgia 12.76 9.79 135 259101 36328 46390498
Transplant rejection 12.73 9.79 21 259215 9575 46417251
Electrocardiogram QT interval abnormal 12.73 9.79 9 259227 151 46426675
Hypochromic anaemia 12.72 9.79 26 259210 1409 46425417
Electrolyte imbalance 12.70 9.79 149 259087 17077 46409749
Carotid artery occlusion 12.69 9.79 38 259198 2621 46424205
Depressed mood 12.64 9.79 121 259115 33198 46393628
Ejection fraction 12.61 9.79 16 259220 576 46426250
Neonatal anuria 12.60 9.79 6 259230 45 46426781
Foetal renal impairment 12.60 9.79 3 259233 0 46426826
Aortic aneurysm repair 12.60 9.79 3 259233 0 46426826
Diabetic enteropathy 12.60 9.79 3 259233 0 46426826
Electrocardiogram RR interval prolonged 12.60 9.79 3 259233 0 46426826
Occult blood positive 12.55 9.79 46 259190 3524 46423302
Herpes zoster 12.54 9.79 284 258952 67588 46359238
Vanishing bile duct syndrome 12.47 9.79 17 259219 657 46426169
Pericardial haemorrhage 12.46 9.79 27 259209 1524 46425302
Cyanopsia 12.45 9.79 4 259232 8 46426818
Antithyroid arthritis syndrome 12.45 9.79 4 259232 8 46426818
Ventricular tachyarrhythmia 12.43 9.79 7 259229 77 46426749
Neuroleptic malignant syndrome 12.42 9.79 27 259209 11095 46415731
Fear 12.42 9.79 141 259095 16031 46410795
Blood albumin abnormal 12.42 9.79 12 259224 317 46426509
Tracheo-oesophageal fistula 12.40 9.79 15 259221 514 46426312
Limb malformation 12.35 9.79 14 259222 447 46426379
Congenital uterine anomaly 12.31 9.79 8 259228 116 46426710
Gastric ulcer 12.30 9.79 180 259056 21683 46405143
Metastases to fallopian tube 12.28 9.79 6 259230 48 46426778
Angiocardiogram 12.28 9.79 6 259230 48 46426778
Haemorrhage 12.25 9.79 395 258841 54474 46372352
Diet noncompliance 12.25 9.79 11 259225 264 46426562
Hypertensive nephropathy 12.22 9.79 13 259223 386 46426440
Renal aplasia 12.21 9.79 10 259226 211 46426615
Capillary disorder 12.20 9.79 7 259229 80 46426746
Peripartum cardiomyopathy 12.14 9.79 8 259228 119 46426707
Renal disorder 12.12 9.79 212 259024 26474 46400352
Rash erythematous 12.09 9.79 127 259109 34223 46392603
Folliculitis 12.08 9.79 10 259226 6193 46420633
Splenic haemorrhage 12.05 9.79 10 259226 215 46426611
Glucose tolerance impaired 12.04 9.79 56 259180 4775 46422051
Mitral valve stenosis 12.03 9.79 22 259214 1097 46425729
Foreign body 12.03 9.79 30 259206 1858 46424968
Left ventricular hypertrophy 11.99 9.79 57 259179 4906 46421920
Flatulence 11.92 9.79 226 259010 28652 46398174
Subclavian artery stenosis 11.91 9.79 8 259228 123 46426703
Irritability 11.90 9.79 103 259133 28843 46397983
Aortic valve sclerosis 11.86 9.79 21 259215 1021 46425805
Non-high-density lipoprotein cholesterol increased 11.85 9.79 8 259228 124 46426702
Blood test abnormal 11.84 9.79 92 259144 9428 46417398
Brain contusion 11.80 9.79 15 259221 541 46426285
Glomerulonephritis rapidly progressive 11.77 9.79 17 259219 694 46426132
Tachycardia 11.77 9.79 671 258565 98951 46327875
Pharyngitis streptococcal 11.74 9.79 18 259218 8450 46418376
Optic ischaemic neuropathy 11.73 9.79 20 259216 943 46425883
Genital labial adhesions 11.72 9.79 5 259231 28 46426798
Spinal cord haematoma 11.69 9.79 9 259227 173 46426653
Hiatus hernia 11.64 9.79 154 259082 18148 46408678
Decreased appetite 11.63 9.79 1238 257998 192598 46234228
Aneurysm 11.56 9.79 36 259200 2537 46424289
Hypoglycaemia 11.55 9.79 389 258847 53960 46372866
Positron emission tomogram abnormal 11.53 9.79 8 259228 130 46426696
Lacunar infarction 11.50 9.79 44 259192 3441 46423385
Nasopharyngitis 11.49 9.79 719 258517 153279 46273547
Therapy non-responder 11.49 9.79 160 259076 40992 46385834
Haemorrhoidal haemorrhage 11.49 9.79 46 259190 3674 46423152
Mydriasis 11.47 9.79 26 259210 10527 46416299
Malignant hypertension 11.47 9.79 21 259215 1048 46425778
Drug withdrawal syndrome 11.46 9.79 97 259139 27287 46399539
Device use error 11.46 9.79 7 259229 5074 46421752
Wheezing 11.45 9.79 218 259018 53168 46373658
Haematotoxicity 11.39 9.79 13 259223 6920 46419906
Anaphylactic shock 11.34 9.79 66 259170 20208 46406618
Gastrointestinal arteriovenous malformation 11.32 9.79 15 259221 564 46426262
Osteonecrosis 11.31 9.79 90 259146 25654 46401172
Pulse absent 11.31 9.79 56 259180 4900 46421926
Hypoaldosteronism 11.31 9.79 9 259227 182 46426644
Fluid overload 11.30 9.79 213 259023 26972 46399854
Demyelination 11.25 9.79 9 259227 5671 46421155
Conjunctival cyst 11.23 9.79 6 259230 59 46426767
Plasma cell myeloma 11.21 9.79 325 258911 44153 46382673
Product residue present 11.19 9.79 47 259189 3835 46422991
Complication associated with device 11.10 9.79 46 259190 15395 46411431
Epinephrine increased 11.08 9.79 4 259232 13 46426813
Cystitis haemorrhagic 11.05 9.79 3 259233 3544 46423282
Psoriatic arthropathy 11.05 9.79 139 259097 36240 46390586
Dyskinesia 10.99 9.79 105 259131 28820 46398006
Unevaluable event 10.99 9.79 335 258901 45840 46380986
Hepatic cyst 10.98 9.79 54 259182 4712 46422114
HELLP syndrome 10.98 9.79 19 259217 907 46425919
Shock 10.82 9.79 176 259060 21669 46405157
Foetal death 10.81 9.79 20 259216 8723 46418103
Pancytopenia 10.81 9.79 375 258861 84683 46342143
Cardiac operation 10.80 9.79 36 259200 2630 46424196
Crohn's disease 10.79 9.79 13 259223 6758 46420068
Hypertransaminasaemia 10.77 9.79 3 259233 3485 46423341
Rabbit syndrome 10.74 9.79 11 259225 312 46426514
Blood electrolytes decreased 10.74 9.79 20 259216 1011 46425815
Microcephaly 10.74 9.79 16 259220 672 46426154
Granuloma skin 10.69 9.79 3 259233 3467 46423359
Somnolence 10.63 9.79 737 258499 155784 46271042
Hyperaesthesia 10.60 9.79 17 259219 7839 46418987
Blood pressure immeasurable 10.60 9.79 22 259214 1205 46425621
Sensitisation 10.58 9.79 16 259220 681 46426145
Cardiac discomfort 10.58 9.79 17 259219 763 46426063
Muscle injury 10.57 9.79 7 259229 4859 46421967
Cerebral artery occlusion 10.57 9.79 19 259217 935 46425891
Central nervous system injury 10.56 9.79 8 259228 150 46426676
Post-anoxic myoclonus 10.56 9.79 5 259231 37 46426789
Cardiac valve disease 10.54 9.79 47 259189 3937 46422889
Intra-aortic balloon placement 10.53 9.79 3 259233 3 46426823
Vascular stent thrombosis 10.49 9.79 18 259218 853 46425973
Eczema eyelids 10.46 9.79 7 259229 107 46426719
Heart injury 10.45 9.79 22 259214 1217 46425609
Lacrimal gland enlargement 10.45 9.79 4 259232 16 46426810
Galactorrhoea 10.44 9.79 4 259232 3793 46423033
Subclavian vein thrombosis 10.39 9.79 28 259208 1818 46425008
Ischaemic cerebral infarction 10.38 9.79 22 259214 1223 46425603
Splenic injury 10.37 9.79 9 259227 206 46426620
Skin tightness 10.36 9.79 46 259190 3847 46422979
Coarctation of the aorta 10.35 9.79 14 259222 537 46426289
Ear infection 10.32 9.79 80 259156 22933 46403893
Microtia 10.28 9.79 11 259225 329 46426497
Thrombotic microangiopathy 10.27 9.79 19 259217 8287 46418539
Aggression 10.23 9.79 79 259157 22665 46404161
Aspergillus infection 10.19 9.79 14 259222 6876 46419950
Therapeutic drug monitoring analysis incorrectly performed 10.17 9.79 8 259228 159 46426667
Injection site bruising 10.15 9.79 138 259098 35498 46391328
Haemorrhagic transformation stroke 10.14 9.79 21 259215 1149 46425677
Urate nephropathy 10.13 9.79 7 259229 113 46426713
Mucosal haemorrhage 10.07 9.79 17 259219 795 46426031
Cerebral infarction 10.03 9.79 184 259052 23182 46403644
Hyponatraemia 10.02 9.79 672 258564 100660 46326166
Hypomania 9.96 9.79 6 259230 4382 46422444
Cystic fibrosis 9.95 9.79 4 259232 3684 46423142
Chest wall haematoma 9.92 9.79 7 259229 117 46426709
Metabolic syndrome 9.92 9.79 22 259214 1262 46425564
Discomfort 9.88 9.79 191 259045 46479 46380347
Therapy partial responder 9.81 9.79 7 259229 4675 46422151

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1122.33 10.68 2772 227667 122853 29599186
Cardiac failure congestive 603.35 10.68 1716 228723 82691 29639348
Coronary artery disease 596.71 10.68 1235 229204 48477 29673562
Bradycardia 506.41 10.68 1371 229068 64155 29657884
Atrial fibrillation 487.15 10.68 1880 228559 106244 29615795
Acute myocardial infarction 320.83 10.68 1016 229423 51923 29670116
Coronary artery bypass 312.58 10.68 283 230156 4879 29717160
Drug abuse 293.36 10.68 132 230307 81940 29640099
Dizziness 250.84 10.68 2443 227996 192466 29529573
Hypotension 234.60 10.68 2465 227974 198100 29523939
Syncope 233.80 10.68 1278 229161 83625 29638414
Off label use 195.76 10.68 1122 229317 248168 29473871
Product prescribing error 192.69 10.68 409 230030 16324 29705715
Coronary arterial stent insertion 175.65 10.68 188 230251 4006 29718033
Febrile neutropenia 154.87 10.68 372 230067 106321 29615718
Neutropenia 152.58 10.68 494 229945 128046 29593993
Pyrexia 152.11 10.68 1491 228948 292998 29429041
Cerebrovascular accident 141.17 10.68 1112 229327 82365 29639674
Dyspnoea 139.03 10.68 3448 226991 329847 29392192
Drug ineffective 136.46 10.68 1824 228615 338563 29383476
Angina unstable 132.70 10.68 293 230146 12017 29710022
Hepatic function abnormal 131.26 10.68 80 230359 41865 29680174
Drug reaction with eosinophilia and systemic symptoms 127.62 10.68 31 230408 28457 29693582
Angina pectoris 105.72 10.68 479 229960 29039 29693000
Product use in unapproved indication 102.14 10.68 263 230176 73430 29648609
Cardiac disorder 97.50 10.68 582 229857 39311 29682728
Atrial flutter 89.08 10.68 277 230162 14004 29708035
Chest pain 85.15 10.68 1324 229115 116303 29605736
Ventricular tachycardia 83.79 10.68 385 230054 23477 29698562
Asthma 83.44 10.68 93 230346 36081 29685958
Interstitial lung disease 83.28 10.68 215 230224 59982 29662057
Vascular graft 82.69 10.68 77 230362 1378 29720661
Treatment failure 80.16 10.68 89 230350 34590 29687449
Asthenia 76.36 10.68 2235 228204 219055 29502984
Fall 74.40 10.68 1878 228561 179994 29542045
Rheumatoid arthritis 73.88 10.68 127 230312 41070 29680969
Hypertensive emergency 73.32 10.68 57 230382 787 29721252
Haematochezia 68.08 10.68 474 229965 33748 29688291
Hepatocellular injury 67.39 10.68 58 230381 25413 29696626
Neutrophil count decreased 63.94 10.68 145 230294 42309 29679730
Coronary artery occlusion 62.86 10.68 209 230230 10948 29711091
International normalised ratio increased 61.88 10.68 600 229839 47139 29674900
Acute coronary syndrome 60.89 10.68 236 230203 13337 29708702
Mucosal inflammation 58.42 10.68 90 230349 30404 29691635
Eosinophilia 57.97 10.68 51 230388 22109 29699930
Septic shock 57.13 10.68 273 230166 63334 29658705
Completed suicide 57.12 10.68 1079 229360 98413 29623626
Gastrointestinal haemorrhage 56.84 10.68 930 229509 82516 29639523
General physical health deterioration 56.72 10.68 1082 229357 98862 29623177
Bone marrow failure 56.02 10.68 89 230350 29696 29692343
Immune reconstitution inflammatory syndrome 54.58 10.68 4 230435 9097 29712942
Thrombocytopenia 53.66 10.68 737 229702 136307 29585732
Drug resistance 53.07 10.68 46 230393 20087 29701952
Arrhythmia 52.80 10.68 436 230003 32733 29689306
Cytomegalovirus infection 52.29 10.68 63 230376 23611 29698428
Drug dependence 52.19 10.68 52 230387 21243 29700796
Lower respiratory tract infection 51.99 10.68 78 230361 26636 29695403
Myocardial ischaemia 51.88 10.68 267 230172 17050 29704989
Infective pulmonary exacerbation of cystic fibrosis 50.75 10.68 4 230435 8568 29713471
Suicidal ideation 50.69 10.68 128 230311 35986 29686053
Fatigue 50.54 10.68 2980 227459 317693 29404346
Seizure 50.39 10.68 499 229940 97976 29624063
Toxic skin eruption 49.30 10.68 12 230427 11003 29711036
Pneumocystis jirovecii pneumonia 49.04 10.68 36 230403 17084 29704955
Rash maculo-papular 48.71 10.68 75 230364 25343 29696696
Sinus bradycardia 48.17 10.68 198 230241 11497 29710542
Infusion related reaction 47.96 10.68 156 230283 40408 29681631
Sopor 47.23 10.68 13 230426 10978 29711061
Coronary artery stenosis 45.94 10.68 164 230275 8906 29713133
Pathogen resistance 44.44 10.68 6 230433 8404 29713635
Bronchopulmonary aspergillosis 43.46 10.68 20 230419 12264 29709775
Palpitations 42.54 10.68 420 230019 33153 29688886
Agitation 42.43 10.68 243 230196 53830 29668209
Heart rate decreased 41.87 10.68 291 230148 20703 29701336
Toxic epidermal necrolysis 41.50 10.68 46 230393 17894 29704145
Therapeutic product effect incomplete 41.48 10.68 128 230311 33706 29688333
Liver disorder 41.20 10.68 106 230333 29616 29692423
Disseminated intravascular coagulation 40.99 10.68 67 230372 22104 29699935
Aggression 40.87 10.68 146 230293 36761 29685278
Abnormal behaviour 38.99 10.68 87 230352 25536 29696503
Nodal arrhythmia 38.71 10.68 40 230399 817 29721222
Lymphopenia 38.59 10.68 27 230412 13136 29708903
Cholestasis 38.56 10.68 84 230355 24866 29697173
Wound 37.69 10.68 192 230247 12210 29709829
Transient ischaemic attack 36.81 10.68 325 230114 24875 29697164
Haemorrhage intracranial 36.51 10.68 219 230220 14813 29707226
Injury 36.39 10.68 289 230150 21442 29700597
Atrioventricular block 36.31 10.68 131 230308 7151 29714888
Agranulocytosis 35.48 10.68 72 230367 21870 29700169
Hyperthermia 34.87 10.68 17 230422 10082 29711957
Headache 33.79 10.68 1107 229332 181199 29540840
Irritability 33.67 10.68 80 230359 22970 29699069
Haematotoxicity 33.58 10.68 4 230435 6166 29715873
Sinus node dysfunction 33.28 10.68 84 230355 3759 29718280
Dehydration 33.23 10.68 1212 229227 122327 29599712
Renal injury 33.18 10.68 178 230261 11551 29710488
Acute generalised exanthematous pustulosis 33.07 10.68 4 230435 6094 29715945
Substance abuse 32.84 10.68 7 230432 7033 29715006
Drug eruption 32.36 10.68 53 230386 17473 29704566
Cardiac arrest 32.23 10.68 939 229500 91911 29630128
Hypertension 31.29 10.68 1185 229254 120169 29601870
Urticaria 31.24 10.68 269 230170 54337 29667702
Blood loss anaemia 30.52 10.68 128 230311 7499 29714540
Anhedonia 30.09 10.68 136 230303 8233 29713806
Overdose 30.01 10.68 462 229977 83875 29638164
Pancytopenia 29.90 10.68 467 229972 84585 29637454
Progressive multifocal leukoencephalopathy 29.88 10.68 16 230423 8997 29713042
Oedema peripheral 29.86 10.68 1044 229395 104788 29617251
Chronotropic incompetence 29.75 10.68 9 230430 7 29722032
Mitral valve disease 29.36 10.68 40 230399 1104 29720935
Acute graft versus host disease 29.12 10.68 5 230434 5859 29716180
Device interaction 28.97 10.68 25 230414 403 29721636
Hyperbilirubinaemia 28.77 10.68 54 230385 16888 29705151
Synovitis 28.77 10.68 20 230419 9763 29712276
Aspergillus infection 28.58 10.68 22 230417 10192 29711847
Fear 28.42 10.68 161 230278 10664 29711375
Altered state of consciousness 28.41 10.68 70 230369 19849 29702190
Presyncope 28.25 10.68 216 230223 15840 29706199
Myxoedema coma 27.80 10.68 21 230418 277 29721762
Unevaluable event 27.80 10.68 370 230069 31415 29690624
Peritonitis 27.55 10.68 79 230360 21296 29700743
Haemophagocytic lymphohistiocytosis 27.51 10.68 21 230418 9770 29712269
Sinus arrest 27.34 10.68 45 230394 1475 29720564
BRASH syndrome 27.16 10.68 11 230428 35 29722004
Supraventricular tachycardia 27.12 10.68 153 230286 10119 29711920
Malignant neoplasm progression 27.09 10.68 392 230047 71895 29650144
Shone complex 26.96 10.68 13 230426 69 29721970
Intentional product use issue 26.87 10.68 167 230272 36273 29685766
Mitral valve incompetence 26.72 10.68 184 230255 13050 29708989
Hepatocellular carcinoma 26.51 10.68 21 230418 9589 29712450
Epilepsy 26.39 10.68 74 230365 20095 29701944
Alanine aminotransferase increased 26.39 10.68 407 230032 73869 29648170
Anaphylactic shock 26.13 10.68 42 230397 13951 29708088
Graft versus host disease 25.78 10.68 24 230415 10126 29711913
Anaphylactic reaction 25.76 10.68 119 230320 27863 29694176
Atrioventricular block complete 25.60 10.68 131 230308 8346 29713693
Neuroleptic malignant syndrome 25.06 10.68 55 230384 16240 29705799
Malaise 25.04 10.68 1040 229399 165922 29556117
Haematoma 24.90 10.68 288 230151 23665 29698374
Respiratory distress 24.88 10.68 150 230289 32822 29689217
Product use issue 24.43 10.68 231 230208 45785 29676254
Jaundice 24.41 10.68 148 230291 32338 29689701
Drug withdrawal syndrome 24.24 10.68 75 230364 19734 29702305
Rash 24.19 10.68 1218 229221 190671 29531368
C-reactive protein increased 24.05 10.68 216 230223 43257 29678782
Aortic stenosis 23.85 10.68 77 230362 3971 29718068
Coma 23.70 10.68 198 230241 40251 29681788
Osteonecrosis 23.57 10.68 56 230383 16079 29705960
Ventricular fibrillation 23.55 10.68 198 230241 14940 29707099
Pericardial haemorrhage 23.44 10.68 62 230377 2856 29719183
Exposure during pregnancy 23.40 10.68 22 230417 9239 29712800
Cardiac operation 23.39 10.68 57 230382 2495 29719544
C-reactive protein abnormal 23.32 10.68 7 230432 5586 29716453
Diffuse large B-cell lymphoma 23.09 10.68 16 230423 7825 29714214
Aspartate aminotransferase increased 23.04 10.68 346 230093 63076 29658963
Respiratory depression 22.95 10.68 33 230406 11470 29710569
Nodular rash 22.87 10.68 11 230428 58 29721981
Erythema multiforme 22.60 10.68 17 230422 7968 29714071
Pneumonia aspiration 22.56 10.68 184 230255 37596 29684443
Stomatitis 22.51 10.68 181 230258 37098 29684941
Drug hypersensitivity 22.49 10.68 381 230058 68138 29653901
Cardiogenic shock 22.37 10.68 213 230226 16648 29705391
Suicide attempt 22.24 10.68 178 230261 36519 29685520
Troponin increased 22.12 10.68 130 230309 8727 29713312
Epstein-Barr virus infection 22.09 10.68 12 230427 6694 29715345
Carcinoma in situ of skin 22.08 10.68 12 230427 85 29721954
Peripheral vascular disorder 22.00 10.68 89 230350 5130 29716909
Hypertriglyceridaemia 21.96 10.68 18 230421 8080 29713959
Hepatitis 21.83 10.68 93 230346 22263 29699776
Aorta hypoplasia 21.62 10.68 12 230427 89 29721950
Chronic graft versus host disease 21.62 10.68 3 230436 4116 29717923
Venoocclusive liver disease 21.55 10.68 12 230427 6601 29715438
Arteriosclerosis 21.50 10.68 150 230289 10683 29711356
Psychomotor hyperactivity 21.42 10.68 19 230420 8205 29713834
Hyponatraemia 21.31 10.68 376 230063 66826 29655213
Hepatitis B 21.30 10.68 10 230429 6062 29715977
Neuropathy vitamin B12 deficiency 21.13 10.68 8 230431 20 29722019
Blood pressure inadequately controlled 21.04 10.68 55 230384 2515 29719524
Erythema 21.00 10.68 445 229994 77006 29645033
Hypoalbuminaemia 20.99 10.68 33 230406 11059 29710980
Blood glucose increased 20.99 10.68 621 229818 60909 29661130
Ascites 20.97 10.68 176 230263 35745 29686294
White blood cell count decreased 20.86 10.68 489 229950 83458 29638581
Colitis 20.82 10.68 145 230294 30675 29691364
Ejection fraction decreased 20.78 10.68 193 230246 14982 29707057
Internal haemorrhage 20.75 10.68 78 230361 4344 29717695
Pacemaker generated rhythm 20.67 10.68 9 230430 36 29722003
Blood pressure increased 20.63 10.68 711 229728 71217 29650822
Hepatojugular reflux 20.59 10.68 19 230420 336 29721703
Product monitoring error 20.55 10.68 43 230396 1698 29720341
Low density lipoprotein abnormal 20.49 10.68 17 230422 259 29721780
Hypertensive crisis 20.45 10.68 122 230317 8235 29713804
Stevens-Johnson syndrome 20.41 10.68 68 230371 17488 29704551
Pancreatitis acute 20.40 10.68 115 230324 25580 29696459
Therapeutic drug monitoring analysis not performed 20.30 10.68 20 230419 385 29721654
Acute lung injury 20.22 10.68 33 230406 1074 29720965
Rhabdomyolysis 20.17 10.68 636 229803 62944 29659095
Nocturia 20.12 10.68 121 230318 8191 29713848
Alcohol abuse 20.08 10.68 8 230431 5345 29716694
Extrapyramidal disorder 20.06 10.68 32 230407 10661 29711378
Coagulopathy 19.99 10.68 224 230215 18263 29703776
Status epilepticus 19.96 10.68 34 230405 11038 29711001
Heart rate irregular 19.96 10.68 162 230277 12097 29709942
Upper motor neurone lesion 19.61 10.68 12 230427 109 29721930
Contusion 19.58 10.68 344 230095 30936 29691103
Oesophageal obstruction 19.53 10.68 20 230419 404 29721635
Mental status changes 19.51 10.68 397 230042 36682 29685357
Cardiac failure 19.48 10.68 806 229633 82612 29639427
Dyskinesia 19.42 10.68 94 230345 21740 29700299
Hepatic encephalopathy 19.37 10.68 51 230388 14141 29707898
Immune thrombocytopenia 19.22 10.68 18 230421 7573 29714466
Hepatitis C 19.15 10.68 46 230393 13159 29708880
Infection 19.06 10.68 456 229983 77618 29644421
Supravalvular aortic stenosis 18.94 10.68 9 230430 46 29721993
Non-cardiac chest pain 18.93 10.68 72 230367 4032 29718007
Leukopenia 18.84 10.68 311 230128 55848 29666191
Nephrogenic systemic fibrosis 18.79 10.68 75 230364 4296 29717743
Large for dates baby 18.77 10.68 28 230411 842 29721197
Toxicity to various agents 18.75 10.68 1144 229295 176039 29546000
Pulmonary tuberculosis 18.65 10.68 7 230432 4850 29717189
Intracardiac thrombus 18.64 10.68 51 230388 2397 29719642
Sedation 18.64 10.68 64 230375 16309 29705730
Leukoencephalopathy 18.63 10.68 4 230435 3998 29718041
Arteriosclerosis coronary artery 18.37 10.68 148 230291 11028 29711011
Tuberculosis 18.36 10.68 21 230418 8056 29713983
Multiple organ dysfunction syndrome 18.33 10.68 361 230078 63126 29658913
Blood pressure abnormal 18.31 10.68 104 230335 6895 29715144
Fracture 18.26 10.68 93 230346 5913 29716126
Occult blood positive 18.20 10.68 67 230372 3693 29718346
Cardiac valve disease 18.20 10.68 57 230382 2892 29719147
Orthostatic hypotension 18.10 10.68 272 230167 23707 29698332
Heart rate increased 17.93 10.68 407 230032 38314 29683725
Pruritus genital 17.89 10.68 20 230419 448 29721591
Macrophages increased 17.89 10.68 13 230426 161 29721878
Dysgeusia 17.83 10.68 279 230160 24522 29697517
Cornea verticillata 17.82 10.68 8 230431 35 29722004
Face oedema 17.64 10.68 38 230401 11296 29710743
Sepsis 17.52 10.68 934 229505 145461 29576578
Stent placement 17.52 10.68 76 230363 4520 29717519
Basal ganglia haemorrhage 17.52 10.68 27 230412 836 29721203
Drug abuser 17.48 10.68 6 230433 4395 29717644
Bundle branch block right 17.36 10.68 103 230336 6939 29715100
Ventricular extrasystoles 17.28 10.68 149 230290 11325 29710714
Full blood count decreased 17.25 10.68 191 230248 15526 29706513
Lower gastrointestinal haemorrhage 17.22 10.68 112 230327 7792 29714247
Gamma-glutamyltransferase increased 17.04 10.68 144 230295 29206 29692833
Psoriatic arthropathy 17.01 10.68 63 230376 15698 29706341
Diabetic foetopathy 16.94 10.68 14 230425 212 29721827
Mitral valve hypoplasia 16.66 10.68 8 230431 42 29721997
Nodal rhythm 16.63 10.68 35 230404 1388 29720651
Sinusitis 16.60 10.68 170 230269 33175 29688864
Gout 16.59 10.68 205 230234 17110 29704929
Orthostatic intolerance 16.58 10.68 24 230415 702 29721337
Atrioventricular block first degree 16.55 10.68 87 230352 5601 29716438
Blood glucose decreased 16.38 10.68 163 230276 12890 29709149
Foetal exposure during pregnancy 16.36 10.68 193 230246 36678 29685361
Anti-neutrophil cytoplasmic antibody positive vasculitis 16.32 10.68 22 230417 601 29721438
Vomiting 16.25 10.68 1463 228976 218355 29503684
Ventricular hypokinesia 16.22 10.68 70 230369 4153 29717886
Blood creatinine increased 16.21 10.68 859 229580 90516 29631523
Atrial thrombosis 16.17 10.68 41 230398 1840 29720199
Mouth ulceration 16.16 10.68 36 230403 10573 29711466
Emotional distress 16.14 10.68 189 230250 15576 29706463
Neonatal respiratory failure 16.03 10.68 16 230423 313 29721726
Penis injury 15.86 10.68 14 230425 233 29721806
Chronic kidney disease 15.78 10.68 392 230047 37446 29684593
Cytomegalovirus chorioretinitis 15.77 10.68 3 230436 3265 29718774
Withdrawal syndrome 15.68 10.68 40 230399 11210 29710829
Dyspnoea exertional 15.66 10.68 370 230069 35060 29686979
Pulmonary renal syndrome 15.66 10.68 12 230427 162 29721877
Systemic infection 15.53 10.68 23 230416 687 29721352
Nephropathy toxic 15.48 10.68 37 230402 10602 29711437
Eczema 15.39 10.68 52 230387 13317 29708722
Eosinophil count increased 15.35 10.68 21 230418 7452 29714587
Cerebral haemorrhage 15.33 10.68 346 230093 32541 29689498
Fluid retention 15.32 10.68 274 230165 24724 29697315
Coronary angioplasty 15.31 10.68 17 230422 378 29721661
Abdominal pain lower 15.28 10.68 118 230321 8680 29713359
Blood urine present 15.14 10.68 129 230310 9771 29712268
Vascular stent thrombosis 15.12 10.68 46 230393 2297 29719742
Uveitis 15.07 10.68 12 230427 5465 29716574
Congenital heart valve disorder 15.04 10.68 8 230431 54 29721985
Haemodilution 15.01 10.68 7 230432 34 29722005
Acute graft versus host disease in skin 15.00 10.68 8 230431 4508 29717531
Product residue present 14.93 10.68 50 230389 2628 29719411
Blood pressure orthostatic 14.91 10.68 8 230431 55 29721984
Lymphoma 14.88 10.68 35 230404 10086 29711953
Device related infection 14.70 10.68 74 230365 16941 29705098
Peritonitis bacterial 14.70 10.68 42 230397 11336 29710703
Intentional self-injury 14.67 10.68 54 230385 13478 29708561
Renal failure 14.63 10.68 1167 229272 127799 29594240
Myelosuppression 14.61 10.68 21 230418 7301 29714738
Biopsy lymph gland 14.57 10.68 8 230431 58 29721981
Obstructive airways disorder 14.41 10.68 30 230409 9029 29713010
Ageusia 14.41 10.68 118 230321 8835 29713204
Cardiovascular insufficiency 14.34 10.68 34 230405 1462 29720577
Precancerous skin lesion 14.31 10.68 20 230419 566 29721473
Electrocardiogram QRS complex prolonged 14.27 10.68 68 230371 4209 29717830
Platelet count decreased 14.25 10.68 669 229770 105460 29616579
Systolic anterior motion of mitral valve 14.25 10.68 7 230432 39 29722000
Post procedural haemorrhage 14.24 10.68 107 230332 7803 29714236
Lung disorder 14.24 10.68 164 230275 31305 29690734
Tumour lysis syndrome 14.24 10.68 51 230388 12834 29709205
Hyperkalaemia 14.11 10.68 632 229807 65378 29656661
Neutropenic sepsis 14.10 10.68 43 230396 11366 29710673
Heart valve incompetence 13.83 10.68 28 230411 1080 29720959
Exercise tolerance decreased 13.74 10.68 62 230377 3750 29718289
Neuropathy peripheral 13.72 10.68 425 230014 70050 29651989
Pallor 13.72 10.68 233 230206 20816 29701223
Haemoglobin decreased 13.69 10.68 1037 229402 113061 29608978
Penile haemorrhage 13.61 10.68 20 230419 593 29721446
Tenosynovitis 13.60 10.68 5 230434 3510 29718529
Heart rate abnormal 13.58 10.68 34 230405 1514 29720525
Multiple-drug resistance 13.57 10.68 3 230436 2938 29719101
Priapism 13.55 10.68 10 230429 4733 29717306
Increased tendency to bruise 13.48 10.68 59 230380 3522 29718517
Essential hypertension 13.48 10.68 46 230393 2442 29719597
Intracranial pressure increased 13.45 10.68 5 230434 3485 29718554
Acoustic stimulation tests abnormal 13.32 10.68 8 230431 70 29721969
Thrombotic microangiopathy 13.29 10.68 29 230410 8581 29713458
Extrasystoles 13.25 10.68 61 230378 3721 29718318
Drug intolerance 13.23 10.68 257 230182 45034 29677005
Nocardiosis 13.23 10.68 5 230434 3450 29718589
Arteriosclerotic gangrene 13.23 10.68 8 230431 71 29721968
Somnolence 13.19 10.68 609 229830 96154 29625885
Cardio-respiratory arrest 13.09 10.68 338 230101 56968 29665071
Neonatal tachycardia 13.07 10.68 5 230434 13 29722026
Pulseless electrical activity 13.07 10.68 87 230352 6100 29715939
Orthopnoea 12.91 10.68 69 230370 4471 29717568
Parathyroid hormone-related protein abnormal 12.81 10.68 5 230434 14 29722025
Obsessive-compulsive disorder 12.81 10.68 8 230431 4133 29717906
Pulmonary valve stenosis congenital 12.75 10.68 10 230429 140 29721899
Cardiac function test abnormal 12.73 10.68 6 230433 30 29722009
Cardiac failure chronic 12.72 10.68 83 230356 5780 29716259
Peritoneal dialysis complication 12.72 10.68 8 230431 4119 29717920
Carcinoid tumour of the gastrointestinal tract 12.72 10.68 7 230432 51 29721988
Dermatitis acneiform 12.71 10.68 15 230424 5674 29716365
Apallic syndrome 12.68 10.68 13 230426 263 29721776
Pulse pressure decreased 12.56 10.68 11 230428 181 29721858
Patent ductus arteriosus 12.54 10.68 53 230386 3116 29718923
Acute lymphocytic leukaemia 12.53 10.68 4 230435 3068 29718971
Hyperferritinaemia 12.49 10.68 15 230424 364 29721675
Bradycardia neonatal 12.46 10.68 24 230415 892 29721147
Asphyxia 12.45 10.68 14 230425 5411 29716628
Glomerular filtration rate decreased 12.43 10.68 138 230301 11224 29710815
Lymphomatoid papulosis 12.37 10.68 11 230428 185 29721854
Euphoric mood 12.31 10.68 9 230430 4281 29717758
Graft versus host disease in skin 12.31 10.68 5 230434 3302 29718737
Psychotic disorder 12.29 10.68 106 230333 21409 29700630
Generalised tonic-clonic seizure 12.23 10.68 94 230345 19457 29702582
Hyperlipidaemia 12.20 10.68 162 230277 13745 29708294
Depression 12.16 10.68 570 229869 89867 29632172
Kidney rupture 12.14 10.68 12 230427 232 29721807
Tricuspid valve incompetence 11.97 10.68 110 230329 8513 29713526
Blood bilirubin increased 11.92 10.68 204 230235 36432 29685607
Chest discomfort 11.91 10.68 445 229994 45035 29677004
Tooth socket haemorrhage 11.88 10.68 5 230434 18 29722021
Hyperammonaemia 11.86 10.68 15 230424 5505 29716534
Circulatory collapse 11.84 10.68 220 230219 19994 29702045
Dizziness postural 11.83 10.68 78 230361 5452 29716587
Facial asymmetry 11.82 10.68 13 230426 286 29721753
Actinic keratosis 11.81 10.68 57 230382 3546 29718493
Dystonia 11.78 10.68 37 230402 9690 29712349
No adverse event 11.74 10.68 82 230357 17337 29704702
Torsade de pointes 11.70 10.68 95 230344 7095 29714944
Blue toe syndrome 11.65 10.68 10 230429 160 29721879
Venous pressure jugular abnormal 11.63 10.68 3 230436 0 29722039
Non-small cell lung cancer stage IIIA 11.63 10.68 3 230436 0 29722039
Paraganglion neoplasm 11.63 10.68 3 230436 0 29722039
Haemorrhage 11.62 10.68 449 229990 45630 29676409
Diverticulum intestinal haemorrhagic 11.58 10.68 39 230400 2056 29719983
Balance disorder 11.55 10.68 365 230074 36128 29685911
Diverticulum 11.52 10.68 90 230349 6643 29715396
Therapeutic product effect decreased 11.48 10.68 156 230283 28920 29693119
Blood cholinesterase decreased 11.47 10.68 9 230430 126 29721913
Oral candidiasis 11.47 10.68 45 230394 11026 29711013
Myelomalacia 11.46 10.68 6 230433 39 29722000
Affect lability 11.43 10.68 6 230433 3412 29718627
High density lipoprotein decreased 11.42 10.68 52 230387 3158 29718881
Thoracic haemorrhage 11.41 10.68 11 230428 206 29721833
Pleural mass 11.40 10.68 7 230432 64 29721975
Halo vision 11.40 10.68 10 230429 165 29721874
Cystitis haemorrhagic 11.37 10.68 12 230427 4775 29717264
Aortic valve sclerosis 11.31 10.68 23 230416 890 29721149
Folliculitis 11.30 10.68 7 230432 3633 29718406
Urinary tract obstruction 11.29 10.68 54 230385 3347 29718692
Schizophrenia 11.25 10.68 34 230405 9014 29713025
Venoocclusive disease 11.25 10.68 3 230436 2587 29719452
Arterial occlusive disease 11.21 10.68 61 230378 3979 29718060
Blood ethanol increased 11.18 10.68 14 230425 355 29721684
Atrial septal defect 11.15 10.68 89 230350 6612 29715427
Iliac artery stenosis 11.15 10.68 8 230431 97 29721942
Aortic aneurysm 11.13 10.68 86 230353 6327 29715712
Acute myeloid leukaemia 11.07 10.68 87 230352 17919 29704120
Blood ketone body increased 11.03 10.68 14 230425 360 29721679
Disease progression 11.02 10.68 502 229937 79372 29642667
Cytopenia 11.02 10.68 30 230409 8226 29713813
Implantable defibrillator insertion 10.98 10.68 20 230419 712 29721327
Aplasia 10.91 10.68 9 230430 4028 29718011
Atrial tachycardia 10.90 10.68 39 230400 2120 29719919
Central nervous system lesion 10.89 10.68 13 230426 4893 29717146
Epidural haemorrhage 10.86 10.68 4 230435 9 29722030
Graft versus host disease in gastrointestinal tract 10.85 10.68 5 230434 3064 29718975
Electrocardiogram ST-T segment abnormal 10.83 10.68 11 230428 220 29721819
Parkinsonism 10.80 10.68 25 230414 7244 29714795
Dermatitis exfoliative 10.79 10.68 26 230413 7430 29714609
Dermatitis bullous 10.77 10.68 19 230420 6085 29715954
Akathisia 10.76 10.68 18 230421 5886 29716153
Blood potassium increased 10.76 10.68 180 230259 16033 29706006
Arterial intramural haematoma 10.76 10.68 6 230433 45 29721994

Pharmacologic Action:

SourceCodeDescription
ATC C07AB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07BB52 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07CB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07FB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013565 Sympatholytics
CHEBI has role CHEBI:35530 beta-adrenoceptor antagonists
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Angina pectoris indication 194828000
Acute coronary syndrome indication 394659003
Myocardial Reinfarction Prevention indication
Supraventricular tachycardia off-label use 6456007
Ventricular tachycardia off-label use 25569003
Atrial fibrillation off-label use 49436004 DOID:0060224
Multifocal atrial tachycardia off-label use 49982000
Paroxysmal supraventricular tachycardia off-label use 67198005
Thyrotoxicosis off-label use 90739004 DOID:7997
Paroxysmal atrial tachycardia off-label use 195069001
Ectopic atrial tachycardia off-label use 233892002
Mitral valve prolapse off-label use 409712001
Diastolic heart failure off-label use 418304008 DOID:9775
Migraine Prevention off-label use
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Pheochromocytoma Adjunct Therapy off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Myasthenia gravis contraindication 91637004 DOID:437
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Azotemia contraindication 445009001
Acute exacerbation of asthma contraindication 708038006
First Degree Atrioventricular Heart Block contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.60 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.30 WOMBAT-PK
Adrenergic receptor beta GPCR IC50 6.30 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.79 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.83 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL

External reference:

IDSource
D00601 KEGG_DRUG
80274-67-5 SECONDARY_CAS_RN
4018393 VANDF
4019836 VANDF
4020875 VANDF
C0025859 UMLSCUI
CHEBI:6904 CHEBI
CHEMBL13 ChEMBL_ID
CHEMBL3989566 ChEMBL_ID
CHEMBL1200337 ChEMBL_ID
CHEMBL2356097 ChEMBL_ID
CHEMBL2062335 ChEMBL_ID
D008790 MESH_DESCRIPTOR_UI
DB00264 DRUGBANK_ID
4171 PUBCHEM_CID
553 IUPHAR_LIGAND_ID
3471 INN_ID
GEB06NHM23 UNII
102313 RXNORM
1073 MMSL
5102 MMSL
5103 MMSL
d00134 MMSL
001853 NDDF
003627 NDDF
003628 NDDF
004135 NDDF
372826007 SNOMEDCT_US
412432007 SNOMEDCT_US
7092007 SNOMEDCT_US
72770009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9660 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9873 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections
TOPROLXL HUMAN PRESCRIPTION DRUG LABEL 1 0186-1088 TABLET, EXTENDED RELEASE 25 mg ORAL NDA 27 sections
TOPROLXL HUMAN PRESCRIPTION DRUG LABEL 1 0186-1090 TABLET, EXTENDED RELEASE 50 mg ORAL NDA 27 sections
TOPROLXL HUMAN PRESCRIPTION DRUG LABEL 1 0186-1092 TABLET, EXTENDED RELEASE 100 mg ORAL NDA 27 sections
TOPROLXL HUMAN PRESCRIPTION DRUG LABEL 1 0186-1094 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 27 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0018 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0032 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0047 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0424 TABLET 50 mg ORAL ANDA 27 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0434 TABLET 100 mg ORAL ANDA 27 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0445 TABLET 100 mg ORAL ANDA 27 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4593 TABLET, FILM COATED 37.50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4594 TABLET, FILM COATED 75 mg ORAL ANDA 23 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4595 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 27 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4596 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL ANDA 27 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4597 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL ANDA 27 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4598 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL ANDA 27 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1778 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 31 sections
METOPROLOL SUCCINULLTE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2600 TABLET, EXTENDED RELEASE 25 mg ORAL NDA authorized generic 27 sections
METOPROLOL SUCCINULLTE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2601 TABLET, EXTENDED RELEASE 50 mg ORAL NDA authorized generic 27 sections
METOPROLOL SUCCINULLTE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2602 TABLET, EXTENDED RELEASE 100 mg ORAL NDA authorized generic 27 sections
METOPROLOL SUCCINULLTE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2603 TABLET, EXTENDED RELEASE 200 mg ORAL NDA authorized generic 27 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-6547 TABLET, FILM COATED 25 mg ORAL ANDA 14 sections
Metoprolol succinate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7823 TABLET, EXTENDED RELEASE 25 mg ORAL ANDA 26 sections
Metoprolol succinate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7824 TABLET, EXTENDED RELEASE 50 mg ORAL ANDA 26 sections
Metoprolol succinate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7825 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 26 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8016 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8017 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
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