metoprolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
beta-adrenoreceptor antagonists	1786	51384-51-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: metoprolol fumarate metoprolol metoprolol succinate beatrolol metoprolol tartrate	A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS. Molecular weight: 267.37 Formula: C15H25NO3 CLOGP: 1.49 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 50.72 ALOGS: -2.82 ROTB: 9 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.15	g	O
0.15	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	1000 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	10 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	24.95 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	38 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	3.10 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	13 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.88 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	3.60 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Aug. 7, 1978	FDA	US PHARMS HOLDINGS I

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	4467.70	30.69	1109	5394	19925	2331657
Toxicity to various agents	2216.18	30.69	711	5792	32043	2319539
Bradycardia	1598.05	30.69	425	6078	9556	2342026
Hypotension	1420.19	30.69	510	5993	31926	2319656
Syncope	778.07	30.69	277	6226	16598	2334984
Dizziness	692.41	30.69	367	6136	58298	2293284
Drug hypersensitivity	672.06	30.69	334	6169	46309	2305273
Cardiac arrest	575.44	30.69	215	6288	14715	2336867
Dyspnoea	513.74	30.69	336	6167	78397	2273185
Overdose	498.58	30.69	210	6293	19697	2331885
Intentional overdose	472.50	30.69	173	6330	11148	2340434
Fall	466.24	30.69	263	6240	46836	2304746
Blood pressure increased	437.84	30.69	183	6320	16803	2334779
Drug interaction	415.88	30.69	208	6295	28955	2322627
Medication error	412.57	30.69	134	6369	5997	2345585
Cardiogenic shock	405.36	30.69	108	6395	2383	2349199
Suicide attempt	374.84	30.69	146	6357	11136	2340446
Atrial fibrillation	373.71	30.69	154	6349	13614	2337968
Cardio-respiratory arrest	371.14	30.69	137	6366	9009	2342573
Palpitations	350.47	30.69	155	6348	16301	2335281
Drug ineffective	329.91	30.69	286	6217	101338	2250244
Hypertension	328.62	30.69	174	6329	27187	2324395
Sinus bradycardia	326.53	30.69	88	6415	2028	2349554
Foetal exposure during pregnancy	325.84	30.69	108	6395	5144	2346438
Maternal exposure during pregnancy	316.41	30.69	140	6363	14723	2336859
Fatigue	281.27	30.69	242	6261	84631	2266951
Exposure during pregnancy	279.17	30.69	152	6351	25067	2326515
Product substitution issue	270.07	30.69	93	6410	4976	2346606
Product prescribing error	266.99	30.69	81	6422	2879	2348703
Death	253.04	30.69	224	6279	81244	2270338
Respiratory arrest	248.40	30.69	92	6411	6086	2345496
Chest pain	245.05	30.69	145	6358	27992	2323590
Nausea	243.50	30.69	253	6250	111936	2239646
General physical health deterioration	240.47	30.69	114	6389	14025	2337557
Tachycardia	221.43	30.69	113	6390	16296	2335286
Condition aggravated	215.52	30.69	140	6363	31839	2319743
Blood pressure decreased	212.56	30.69	92	6411	9144	2342438
Hyperkalaemia	212.32	30.69	81	6422	5812	2345770
Poisoning	207.31	30.69	66	6437	2754	2348828
Heart rate decreased	205.71	30.69	70	6433	3606	2347976
Inappropriate schedule of product administration	194.06	30.69	94	6409	12110	2339472
Arrhythmia	192.81	30.69	76	6427	5952	2345630
Heart rate increased	190.13	30.69	90	6413	11015	2340567
Blood pressure inadequately controlled	184.87	30.69	47	6456	853	2350729
Acute kidney injury	184.20	30.69	121	6382	28001	2323581
Presyncope	184.12	30.69	65	6438	3738	2347844
Confusional state	179.82	30.69	113	6390	24231	2327351
Pulmonary oedema	171.51	30.69	74	6429	7289	2344293
Premature baby	171.40	30.69	59	6444	3145	2348437
Asthenia	169.49	30.69	141	6362	46785	2304797
Ventricular tachycardia	167.13	30.69	57	6446	2954	2348628
Malaise	166.38	30.69	150	6353	55435	2296147
Somnolence	158.48	30.69	103	6400	23382	2328200
Off label use	157.20	30.69	165	6338	73433	2278149
Atrioventricular block	157.02	30.69	44	6459	1173	2350409
Premature delivery	156.05	30.69	55	6448	3145	2348437
Orthostatic hypotension	153.93	30.69	53	6450	2826	2348756
Circulatory collapse	151.64	30.69	56	6447	3664	2347918
Coma	147.66	30.69	71	6432	8985	2342597
Caesarean section	146.59	30.69	56	6447	4025	2347557
Peripheral swelling	145.94	30.69	88	6415	17509	2334073
Loss of consciousness	145.79	30.69	90	6413	18677	2332905
Shock	144.03	30.69	55	6448	3949	2347633
Drug abuse	136.96	30.69	74	6429	11952	2339630
Respiratory depression	135.93	30.69	45	6458	2125	2349457
Anuria	135.30	30.69	43	6460	1781	2349801
Decorticate posture	135.07	30.69	22	6481	24	2351558
Vomiting	134.37	30.69	150	6353	71452	2280130
Oedema peripheral	133.40	30.69	93	6410	23670	2327912
Myocardial depression	132.26	30.69	23	6480	48	2351534
Ventricular extrasystoles	132.13	30.69	43	6460	1923	2349659
Hypoglycaemia	131.28	30.69	64	6439	8343	2343239
Nodal rhythm	130.13	30.69	30	6473	352	2351230
Electrocardiogram QT prolonged	129.61	30.69	62	6441	7752	2343830
Heart rate irregular	127.10	30.69	44	6459	2383	2349199
Low birth weight baby	125.55	30.69	34	6469	795	2350787
Cardiac failure	122.79	30.69	69	6434	12025	2339557
Metabolic acidosis	122.55	30.69	55	6448	5943	2345639
Intentional product misuse	121.06	30.69	63	6440	9426	2342156
Insomnia	119.82	30.69	90	6413	25697	2325885
Feeling abnormal	117.86	30.69	86	6417	23495	2328087
Unresponsive to stimuli	116.77	30.69	50	6453	4826	2346756
Acute myocardial infarction	115.03	30.69	50	6453	5005	2346577
Torsade de pointes	114.84	30.69	40	6463	2206	2349376
Angioedema	113.60	30.69	58	6445	8338	2343244
Product administration error	113.14	30.69	46	6457	3897	2347685
Depressed level of consciousness	113.07	30.69	56	6447	7548	2344034
Hyponatraemia	111.36	30.69	67	6436	13258	2338324
Ventricular hypokinesia	110.76	30.69	29	6474	593	2350989
Dehydration	108.44	30.69	80	6423	22215	2329367
Atrial flutter	108.36	30.69	33	6470	1184	2350398
Left ventricular dysfunction	107.75	30.69	33	6470	1207	2350375
Decreased appetite	106.55	30.69	88	6415	28803	2322779
Labelled drug-drug interaction medication error	106.01	30.69	33	6470	1275	2350307
Chest discomfort	105.74	30.69	67	6436	14528	2337054
Myocardial infarction	105.69	30.69	74	6429	18939	2332643
Deep vein thrombosis	105.42	30.69	64	6439	12868	2338714
Lymphatic fistula	104.22	30.69	16	6487	7	2351575
Conjoined twins	101.07	30.69	16	6487	12	2351570
Femoral hernia incarcerated	100.51	30.69	16	6487	13	2351569
Ejection fraction decreased	99.00	30.69	38	6465	2763	2348819
Hypothermia	97.43	30.69	35	6468	2113	2349469
Pancreatic steatosis	96.95	30.69	17	6486	38	2351544
Blood creatinine increased	95.93	30.69	56	6447	10477	2341105
Cough	94.18	30.69	87	6416	33030	2318552
Blood pressure systolic increased	90.86	30.69	34	6469	2305	2349277
Arthralgia	90.29	30.69	107	6396	54178	2297404
Hypoxia	90.02	30.69	45	6458	6182	2345400
Product quality issue	89.29	30.69	54	6449	10775	2340807
Foetal growth restriction	89.20	30.69	28	6475	1112	2350470
Anxiety	89.08	30.69	80	6423	29279	2322303
Myalgia	87.93	30.69	72	6431	23261	2328321
Congenital hydronephrosis	87.37	30.69	16	6487	50	2351532
Headache	86.87	30.69	128	6375	80051	2271531
Cardiotoxicity	86.73	30.69	28	6475	1219	2350363
Hyperhidrosis	85.62	30.69	60	6443	15362	2336220
Ventricular fibrillation	85.51	30.69	32	6471	2169	2349413
Coma scale abnormal	85.03	30.69	25	6478	793	2350789
Drug intolerance	84.73	30.69	57	6446	13660	2337922
Diarrhoea	84.26	30.69	129	6374	83435	2268147
Wound infection pseudomonas	83.14	30.69	16	6487	70	2351512
Abdominal discomfort	81.17	30.69	61	6442	17395	2334187
Mitral valve incompetence	80.93	30.69	32	6471	2518	2349064
Atrioventricular block first degree	80.90	30.69	25	6478	942	2350640
Atrial septal defect	80.68	30.69	27	6476	1317	2350265
Muscular weakness	80.47	30.69	57	6446	14840	2336742
Allergic reaction to excipient	80.27	30.69	15	6488	54	2351528
Pulmonary hypertension	79.96	30.69	39	6464	5079	2346503
Acute respiratory distress syndrome	79.60	30.69	34	6469	3258	2348324
Tinnitus	76.85	30.69	38	6465	5097	2346485
Small for dates baby	76.48	30.69	22	6481	645	2350937
Back pain	76.40	30.69	76	6427	31583	2319999
Atrioventricular block complete	75.43	30.69	26	6477	1388	2350194
Arterial haemorrhage	75.15	30.69	17	6486	182	2351400
Pain	73.13	30.69	103	6400	61754	2289828
Exposure via ingestion	72.85	30.69	22	6481	766	2350816
Atrioventricular block second degree	71.72	30.69	21	6482	656	2350926
Intestinal malrotation	71.13	30.69	13	6490	40	2351542
Product monitoring error	70.91	30.69	15	6488	114	2351468
Aortic valve stenosis	70.90	30.69	18	6485	324	2351258
Placental insufficiency	70.75	30.69	17	6486	241	2351341
Urachal abnormality	70.22	30.69	11	6492	7	2351575
Cardiac failure acute	69.85	30.69	23	6480	1066	2350516
Gait disturbance	69.46	30.69	62	6441	22483	2329099
Ventricular arrhythmia	69.18	30.69	20	6483	597	2350985
Premature labour	68.84	30.69	27	6476	2079	2349503
Eructation	68.38	30.69	23	6480	1139	2350443
Tachyarrhythmia	68.33	30.69	20	6483	624	2350958
Blood pressure fluctuation	68.27	30.69	26	6477	1849	2349733
Persistent cloaca	67.53	30.69	11	6492	12	2351570
Accidental overdose	67.29	30.69	32	6471	3940	2347642
Diverticulum intestinal	67.20	30.69	20	6483	662	2350920
Orthostatic intolerance	66.79	30.69	15	6488	155	2351427
Musculoskeletal stiffness	66.45	30.69	47	6456	12200	2339382
Labile hypertension	65.96	30.69	13	6490	66	2351516
Cardiovascular disorder	65.92	30.69	27	6476	2328	2349254
Congenital bladder anomaly	65.36	30.69	11	6492	17	2351565
Discomfort	65.03	30.69	34	6469	5125	2346457
Bradyarrhythmia	64.76	30.69	17	6486	351	2351231
Seroma	64.67	30.69	16	6487	258	2351324
Aortic arteriosclerosis	64.36	30.69	19	6484	611	2350971
Angina pectoris	64.14	30.69	31	6472	3956	2347626
Lactic acidosis	63.98	30.69	34	6469	5296	2346286
Visual impairment	63.52	30.69	45	6458	11710	2339872
Blood pressure abnormal	63.36	30.69	24	6479	1681	2349901
Coronary artery disease	63.27	30.69	35	6468	5904	2345678
Depression	63.21	30.69	65	6438	28067	2323515
Encephalopathy	63.09	30.69	32	6471	4529	2347053
Supraventricular tachycardia	63.01	30.69	25	6478	1984	2349598
Pain in extremity	62.77	30.69	79	6424	42461	2309121
Hypokalaemia	62.74	30.69	43	6460	10611	2340971
Sinus node dysfunction	62.55	30.69	19	6484	675	2350907
Haemarthrosis	62.29	30.69	17	6486	409	2351173
Anaemia	61.78	30.69	71	6432	34721	2316861
Peripheral arterial occlusive disease	61.21	30.69	18	6485	571	2351011
Product complaint	60.33	30.69	31	6472	4507	2347075
Haemodynamic instability	60.26	30.69	21	6482	1158	2350424
Renal impairment	60.06	30.69	41	6462	10051	2341531
Renal failure	60.06	30.69	51	6452	17298	2334284
Limb malformation	59.90	30.69	13	6490	113	2351469
Adverse drug reaction	59.88	30.69	38	6465	8245	2343337
Blood glucose increased	59.46	30.69	44	6459	12246	2339336
Abdominal pain	59.11	30.69	69	6434	34305	2317277
Hepatic cyst	59.11	30.69	18	6485	645	2350937
Abdominal pain upper	58.79	30.69	56	6447	22044	2329538
Disorientation	58.31	30.69	34	6469	6338	2345244
Optic ischaemic neuropathy	58.12	30.69	15	6488	289	2351293
Body temperature decreased	57.90	30.69	21	6482	1302	2350280
Sleep disorder	57.73	30.69	34	6469	6455	2345127
Weight decreased	57.41	30.69	62	6441	28309	2323273
Tricuspid valve incompetence	56.84	30.69	22	6481	1634	2349948
Oligohydramnios	56.48	30.69	19	6484	941	2350641
Dysarthria	56.01	30.69	33	6470	6269	2345313
Hiatus hernia	55.30	30.69	23	6480	2061	2349521
Drug level increased	55.13	30.69	25	6478	2762	2348820
Patent ductus arteriosus	54.59	30.69	17	6486	657	2350925
Hypertensive crisis	54.36	30.69	24	6479	2489	2349093
Fryns syndrome	54.06	30.69	8	6495	1	2351581
Wound dehiscence	53.88	30.69	17	6486	686	2350896
Electrocardiogram abnormal	53.82	30.69	20	6483	1328	2350254
Peripheral coldness	53.05	30.69	21	6482	1656	2349926
Inflammatory marker increased	52.95	30.69	16	6487	558	2351024
Urticaria	52.58	30.69	55	6448	24206	2327376
Wound	52.47	30.69	24	6479	2704	2348878
Gastrointestinal haemorrhage	52.39	30.69	41	6462	12394	2339188
Electrocardiogram T wave inversion	51.02	30.69	16	6487	633	2350949
Renal dysplasia	50.86	30.69	10	6493	50	2351532
Normal newborn	50.85	30.69	19	6484	1281	2350301
Atrial tachycardia	50.82	30.69	14	6489	349	2351233
Muscle spasms	50.55	30.69	51	6452	21515	2330067
Seizure	50.42	30.69	54	6449	24412	2327170
Tracheo-oesophageal fistula	49.86	30.69	11	6492	104	2351478
Aplastic anaemia	49.68	30.69	17	6486	887	2350695
Faecaloma	49.48	30.69	17	6486	898	2350684
Asthma	49.17	30.69	38	6465	11276	2340306
Blood pressure systolic decreased	48.64	30.69	16	6487	739	2350843
Middle insomnia	48.49	30.69	19	6484	1458	2350124
Urinary tract infection	47.98	30.69	58	6445	29884	2321698
Pruritus	47.95	30.69	70	6433	43270	2308312
Loss of employment	47.70	30.69	11	6492	129	2351453
Erythema	47.45	30.69	53	6450	25106	2326476
Cardiac disorder	47.02	30.69	32	6471	7801	2343781
Microcephaly	46.95	30.69	11	6492	139	2351443
Congenital diaphragmatic hernia	46.65	30.69	9	6494	40	2351542
Oliguria	46.48	30.69	18	6485	1339	2350243
Phaeochromocytoma crisis	46.46	30.69	9	6494	41	2351541
Lethargy	46.18	30.69	33	6470	8697	2342885
Cyanosis	45.96	30.69	23	6480	3162	2348420
Dyspnoea exertional	45.77	30.69	28	6475	5692	2345890
Congenital choroid plexus cyst	45.61	30.69	9	6494	46	2351536
Pallor	45.27	30.69	24	6479	3718	2347864
Joint dislocation	45.25	30.69	18	6485	1438	2350144
Supraventricular extrasystoles	45.02	30.69	15	6488	721	2350861
Agitation neonatal	44.91	30.69	10	6493	99	2351483
Microtia	43.97	30.69	9	6494	57	2351525
Osteopenia	43.54	30.69	19	6484	1916	2349666
Hypersensitivity	43.29	30.69	49	6454	23544	2328038
Renal impairment neonatal	43.28	30.69	7	6496	7	2351575
Congenital nail disorder	43.21	30.69	8	6495	27	2351555
Escherichia infection	43.06	30.69	17	6486	1331	2350251
Gastrointestinal tract mucosal pigmentation	42.98	30.69	8	6495	28	2351554
Cardiomegaly	42.72	30.69	20	6483	2376	2349206
Polyhydramnios	42.68	30.69	12	6491	323	2351259
Embolism venous	42.47	30.69	12	6491	329	2351253
Proteinuria	42.36	30.69	21	6482	2829	2348753
Arteriospasm coronary	42.06	30.69	14	6489	671	2350911
Cleft palate	41.90	30.69	11	6492	227	2351355
Ischaemic stroke	41.70	30.69	22	6481	3375	2348207
Hallucination, visual	41.48	30.69	21	6482	2958	2348624
Postoperative wound infection	41.44	30.69	16	6487	1180	2350402
Pre-eclampsia	41.26	30.69	17	6486	1487	2350095
Balance disorder	40.75	30.69	32	6471	9715	2341867
Intentional self-injury	40.36	30.69	23	6480	4104	2347478
Pulseless electrical activity	40.30	30.69	15	6488	1000	2350582
Extrasystoles	40.25	30.69	15	6488	1004	2350578
Rash	40.11	30.69	77	6426	59481	2292101
Drug-induced liver injury	39.94	30.69	22	6481	3677	2347905
Neonatal respiratory failure	39.60	30.69	8	6495	47	2351535
Groin pain	39.56	30.69	16	6487	1334	2350248
Sinus tachycardia	39.30	30.69	21	6482	3304	2348278
Agitation	39.28	30.69	33	6470	11018	2340564
Purpura senile	39.23	30.69	7	6496	18	2351564
Therapeutic response unexpected	39.07	30.69	22	6481	3837	2347745
Haemoglobin decreased	39.05	30.69	41	6462	18110	2333472
Dry mouth	38.68	30.69	29	6474	8224	2343358
Drug ineffective for unapproved indication	38.66	30.69	20	6483	2946	2348636
Dyspepsia	38.34	30.69	31	6472	9813	2341769
Oesophageal atresia	38.03	30.69	9	6494	119	2351463
Tachypnoea	37.87	30.69	18	6485	2211	2349371
Hypoperfusion	37.79	30.69	10	6493	213	2351369
Alopecia	37.51	30.69	44	6459	21957	2329625
Urinary retention	37.38	30.69	21	6482	3646	2347936
Paraesthesia	37.37	30.69	44	6459	22044	2329538
Brain oedema	37.26	30.69	18	6485	2292	2349290
Reaction to excipient	37.16	30.69	11	6492	357	2351225
Apallic syndrome	36.92	30.69	9	6494	136	2351446
Pulmonary hypoplasia	36.51	30.69	8	6495	73	2351509
Joint swelling	36.19	30.69	38	6465	16781	2334801
Coarctation of the aorta	36.15	30.69	9	6494	149	2351433
Dysmorphism	36.01	30.69	11	6492	398	2351184
Ventricular septal defect	35.94	30.69	13	6490	799	2350783
Electrocardiogram QRS complex prolonged	35.56	30.69	14	6489	1088	2350494
Hypoaesthesia	35.41	30.69	41	6462	20174	2331408
Delirium	35.36	30.69	23	6480	5200	2346382
Blood creatine increased	34.89	30.69	12	6491	636	2350946
Urinary incontinence	34.58	30.69	21	6482	4212	2347370
Miosis	34.13	30.69	14	6489	1210	2350372
Left ventricular hypertrophy	33.80	30.69	12	6491	699	2350883
Weight increased	33.71	30.69	42	6461	22295	2329287
Dry eye	33.28	30.69	20	6483	3936	2347646
Swelling face	33.02	30.69	28	6475	9465	2342117
Eye oedema	32.76	30.69	10	6493	361	2351221
Chronic kidney disease	32.54	30.69	20	6483	4098	2347484
Still's disease	32.39	30.69	8	6495	128	2351454
Peripartum cardiomyopathy	32.24	30.69	7	6496	61	2351521
Gastrooesophageal reflux disease	31.99	30.69	27	6476	9068	2342514
Orthopnoea	31.01	30.69	11	6492	639	2350943
Alveolitis	30.90	30.69	10	6493	438	2351144
Environmental exposure	30.86	30.69	6	6497	28	2351554
Flatulence	30.81	30.69	20	6483	4505	2347077
Myocarditis	30.77	30.69	13	6490	1210	2350372

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	3073.82	28.58	863	5345	15449	1725124
Bradycardia	2933.92	28.58	760	5448	9774	1730799
Hypotension	2026.31	28.58	726	5482	28928	1711645
Toxicity to various agents	1498.27	28.58	581	5627	28560	1712013
Syncope	1356.49	28.58	449	5759	13720	1726853
Dizziness	1232.83	28.58	530	5678	33831	1706742
Cardiac arrest	600.13	28.58	256	5952	15674	1724899
Product prescribing error	563.50	28.58	153	6055	2257	1738316
Dyspnoea	552.60	28.58	357	5851	51702	1688871
Fall	492.00	28.58	264	5944	26950	1713623
Intentional overdose	428.65	28.58	164	6044	7506	1733067
Atrial fibrillation	415.17	28.58	195	6013	14916	1725657
Overdose	375.73	28.58	188	6020	16513	1724060
Heart rate decreased	343.86	28.58	108	6100	2701	1737872
Sinus bradycardia	312.17	28.58	92	6116	1841	1738732
Hyperkalaemia	303.14	28.58	132	6076	8415	1732158
Hypertension	288.30	28.58	166	6042	19282	1721291
Asthenia	276.02	28.58	200	6008	34470	1706103
Fatigue	272.70	28.58	232	5976	50549	1690024
Foetal exposure during pregnancy	264.46	28.58	110	6098	6249	1734324
Orthostatic hypotension	256.46	28.58	91	6117	3340	1737233
Suicide attempt	242.22	28.58	108	6100	7273	1733300
Drug hypersensitivity	228.89	28.58	131	6077	15004	1725569
Drug interaction	221.53	28.58	161	6047	27797	1712776
Acute kidney injury	208.52	28.58	170	6038	34774	1705799
Atrioventricular block	207.10	28.58	62	6146	1309	1739264
Presyncope	207.05	28.58	73	6135	2625	1737948
Drug ineffective	205.64	28.58	220	5988	63581	1676992
Atrioventricular block complete	190.08	28.58	59	6149	1412	1739161
Blood pressure increased	189.53	28.58	103	6105	10650	1729923
Intentional product misuse	183.30	28.58	89	6119	7269	1733304
Metabolic acidosis	173.77	28.58	78	6130	5324	1735249
Chest pain	172.02	28.58	121	6087	19793	1720780
Palpitations	171.46	28.58	83	6125	6731	1733842
Atrial septal defect	160.97	28.58	51	6157	1307	1739266
Cardio-respiratory arrest	160.88	28.58	88	6120	9205	1731368
Arrhythmia	159.59	28.58	76	6132	5940	1734633
Shock	159.54	28.58	68	6140	4093	1736480
Premature baby	157.13	28.58	61	6147	2881	1737692
Nausea	154.86	28.58	171	6037	51025	1689548
Hypoglycaemia	154.68	28.58	83	6125	8355	1732218
Ventricular tachycardia	152.02	28.58	64	6144	3734	1736839
Cardiac failure	148.52	28.58	93	6115	12509	1728064
Medication error	147.80	28.58	67	6141	4676	1735897
General physical health deterioration	147.58	28.58	94	6114	13024	1727549
Acute lung injury	147.43	28.58	32	6176	165	1740408
Condition aggravated	145.36	28.58	112	6096	21038	1719535
Blood pressure decreased	139.53	28.58	75	6133	7571	1733002
Exposure via ingestion	139.36	28.58	39	6169	641	1739932
Respiratory arrest	137.49	28.58	68	6140	5771	1734802
Poisoning	136.98	28.58	53	6155	2479	1738094
Unresponsive to stimuli	136.71	28.58	63	6145	4566	1736007
Blood pressure systolic increased	134.07	28.58	47	6161	1658	1738915
Actinic keratosis	126.64	28.58	35	6173	548	1740025
Cough	121.77	28.58	97	6111	19100	1721473
Wound	120.69	28.58	43	6165	1591	1738982
Drug abuse	119.96	28.58	84	6124	13605	1726968
Chest discomfort	117.44	28.58	66	6142	7265	1733308
Somnolence	115.70	28.58	89	6119	16650	1723923
Cardiogenic shock	113.94	28.58	46	6162	2408	1738165
Hyperhidrosis	112.61	28.58	78	6130	12410	1728163
Death	112.43	28.58	193	6015	87250	1653323
Contraindicated product administered	110.44	28.58	39	6169	1405	1739168
Ventricular fibrillation	108.78	28.58	46	6162	2710	1737863
Patent ductus arteriosus	108.12	28.58	32	6176	647	1739926
Renal failure	107.82	28.58	92	6116	19925	1720648
Atrioventricular block first degree	106.15	28.58	34	6174	902	1739671
Oedema peripheral	103.78	28.58	81	6127	15469	1725104
Headache	102.21	28.58	114	6094	34262	1706311
Body temperature decreased	101.41	28.58	34	6174	1045	1739528
Heart rate irregular	100.77	28.58	38	6170	1654	1738919
Inappropriate schedule of product administration	100.45	28.58	60	6148	7399	1733174
Dyspnoea exertional	99.53	28.58	49	6159	4112	1736461
Dehydration	98.85	28.58	83	6125	17575	1722998
Ejection fraction decreased	97.10	28.58	40	6168	2205	1738368
Tachycardia	95.75	28.58	71	6137	12557	1728016
Small for dates baby	94.28	28.58	28	6180	573	1740000
Depressed level of consciousness	93.93	28.58	55	6153	6537	1734036
Blood pressure inadequately controlled	93.73	28.58	28	6180	585	1739988
Angina pectoris	93.67	28.58	50	6158	4968	1735605
Circulatory collapse	92.49	28.58	44	6164	3423	1737150
Heart rate increased	91.92	28.58	54	6154	6456	1734117
Off label use	88.36	28.58	112	6096	38459	1702114
Low birth weight baby	87.53	28.58	29	6179	858	1739715
Electrocardiogram QRS complex prolonged	87.26	28.58	28	6180	747	1739826
Hypospadias	86.46	28.58	26	6182	556	1740017
Nodal rhythm	85.78	28.58	23	6185	319	1740254
Diarrhoea	84.03	28.58	130	6078	53722	1686851
Coma	83.95	28.58	53	6155	7209	1733364
Loss of consciousness	83.38	28.58	70	6138	14805	1725768
Confusional state	81.78	28.58	81	6127	21197	1719376
Speech disorder	81.19	28.58	44	6164	4504	1736069
Blood pressure diastolic decreased	79.97	28.58	26	6182	724	1739849
Sinus arrest	79.72	28.58	22	6186	342	1740231
Myocardial infarction	78.76	28.58	89	6119	27085	1713488
Mental status changes	76.95	28.58	47	6161	6028	1734545
Anxiety	76.74	28.58	68	6140	15459	1725114
Lethargy	74.57	28.58	49	6159	7135	1733438
Hyperlipidaemia	74.20	28.58	33	6175	2196	1738377
Sinus node dysfunction	73.75	28.58	24	6184	670	1739903
Lactic acidosis	73.59	28.58	43	6165	5086	1735487
Malaise	72.67	28.58	89	6119	29476	1711097
Hypokalaemia	72.37	28.58	46	6162	6328	1734245
Abdominal pain	72.02	28.58	76	6132	21414	1719159
Product substitution issue	70.62	28.58	36	6172	3250	1737323
Electrocardiogram ST segment elevation	70.50	28.58	25	6183	911	1739662
Vomiting	70.46	28.58	100	6108	38215	1702358
Gait disturbance	69.70	28.58	59	6149	12611	1727962
Pain	68.36	28.58	82	6126	26575	1713998
Erectile dysfunction	67.96	28.58	39	6169	4458	1736115
Atrioventricular block second degree	67.68	28.58	22	6186	612	1739961
Dysarthria	67.40	28.58	41	6167	5218	1735355
Oesophageal obstruction	67.17	28.58	15	6193	90	1740483
Bezoar	66.89	28.58	16	6192	135	1740438
Blood creatinine increased	64.80	28.58	59	6149	13887	1726686
Sinus tachycardia	64.07	28.58	31	6177	2501	1738072
Bowen's disease	64.06	28.58	18	6190	300	1740273
Hepatotoxicity	64.00	28.58	33	6175	3051	1737522
Pulmonary oedema	63.71	28.58	43	6165	6543	1734030
Bundle branch block right	63.16	28.58	25	6183	1240	1739333
Pain in extremity	63.07	28.58	66	6142	18406	1722167
Nodal arrhythmia	62.03	28.58	16	6192	189	1740384
Basal cell carcinoma	61.62	28.58	30	6178	2453	1738120
Fracture	59.82	28.58	23	6185	1055	1739518
Blood glucose increased	59.67	28.58	50	6158	10534	1730039
Drug intolerance	59.64	28.58	40	6168	6022	1734551
Macrophages increased	58.32	28.58	10	6198	8	1740565
Cardiotoxicity	58.15	28.58	21	6187	807	1739766
Large for dates baby	57.82	28.58	14	6194	125	1740448
Pulseless electrical activity	57.45	28.58	22	6186	998	1739575
Atrial flutter	55.94	28.58	26	6182	1916	1738657
Acidosis	55.78	28.58	24	6184	1473	1739100
Electrocardiogram QT prolonged	55.54	28.58	37	6171	5508	1735065
Carcinoma in situ of skin	54.21	28.58	11	6197	38	1740535
Therapeutic drug monitoring analysis not performed	53.80	28.58	9	6199	5	1740568
Brain injury	53.67	28.58	21	6187	1010	1739563
Apnoea	53.24	28.58	23	6185	1426	1739147
Renal impairment	53.13	28.58	50	6158	12264	1728309
Vasoplegia syndrome	52.62	28.58	14	6194	188	1740385
Skin ulcer	52.62	28.58	28	6180	2760	1737813
Seizure	52.55	28.58	63	6145	20378	1720195
Product monitoring error	52.14	28.58	12	6196	84	1740489
Blood pressure fluctuation	52.08	28.58	22	6186	1290	1739283
Ventricular septal defect	51.91	28.58	19	6189	759	1739814
Precancerous skin lesion	51.75	28.58	13	6195	137	1740436
Facial asymmetry	51.63	28.58	11	6197	51	1740522
Tachypnoea	51.15	28.58	26	6182	2332	1738241
Bradycardia neonatal	51.07	28.58	14	6194	212	1740361
Muscular weakness	50.82	28.58	45	6163	10204	1730369
Abdominal distension	50.51	28.58	37	6171	6407	1734166
Poisoning deliberate	50.44	28.58	19	6189	823	1739750
Left ventricular hypertrophy	50.23	28.58	19	6189	833	1739740
Supraventricular tachycardia	50.20	28.58	23	6185	1640	1738933
Substance-induced psychotic disorder	48.25	28.58	14	6194	263	1740310
Bradyarrhythmia	47.96	28.58	15	6193	367	1740206
Pulse absent	47.20	28.58	19	6189	985	1739588
Ventricular extrasystoles	46.86	28.58	23	6185	1913	1738660
Hypoglycaemia neonatal	46.52	28.58	14	6194	300	1740273
Chronic obstructive pulmonary disease	46.25	28.58	34	6174	5919	1734654
Hepatic ischaemia	45.67	28.58	10	6198	54	1740519
Acute coronary syndrome	45.42	28.58	24	6184	2331	1738242
Vomiting projectile	45.11	28.58	12	6196	161	1740412
Coronary artery stenosis	45.01	28.58	21	6187	1561	1739012
Blood ethanol increased	44.63	28.58	10	6198	61	1740512
Shone complex	44.03	28.58	8	6200	12	1740561
Feeling abnormal	43.74	28.58	43	6165	11123	1729450
Chronotropic incompetence	43.64	28.58	8	6200	13	1740560
Aorta hypoplasia	43.51	28.58	9	6199	35	1740538
Diplopia	43.46	28.58	24	6184	2546	1738027
Blood sodium decreased	43.08	28.58	23	6185	2281	1738292
Heart rate abnormal	42.91	28.58	13	6195	285	1740288
Stress	42.84	28.58	24	6184	2617	1737956
Weight decreased	42.64	28.58	60	6148	22693	1717880
Balance disorder	42.48	28.58	32	6176	5780	1734793
Pulmonary congestion	42.37	28.58	21	6187	1784	1738789
International normalised ratio increased	42.26	28.58	37	6171	8262	1732311
Haemodynamic instability	41.96	28.58	19	6189	1318	1739255
Erythema	41.92	28.58	47	6161	14141	1726432
Supravalvular aortic stenosis	41.77	28.58	7	6201	4	1740569
Incorrect dose administered	41.73	28.58	35	6173	7374	1733199
Maternal drugs affecting foetus	41.10	28.58	18	6190	1153	1739420
Cardiac failure congestive	40.77	28.58	48	6160	15222	1725351
Vertigo	40.73	28.58	28	6180	4385	1736188
Needle issue	40.72	28.58	15	6193	610	1739963
Systolic anterior motion of mitral valve	40.61	28.58	7	6201	6	1740567
Coronary artery disease	40.59	28.58	39	6169	9807	1730766
Depression	40.58	28.58	50	6158	16619	1723954
Agitation	40.49	28.58	41	6167	10985	1729588
Scratch	40.31	28.58	14	6194	479	1740094
Pruritus	40.24	28.58	59	6149	23163	1717410
Feeling hot	40.10	28.58	24	6184	2963	1737610
Hyponatraemia	39.68	28.58	37	6171	8963	1731610
Drug withdrawal convulsions	39.40	28.58	12	6196	268	1740305
Drug level increased	39.07	28.58	23	6185	2754	1737819
Coagulopathy	39.04	28.58	23	6185	2758	1737815
Mydriasis	38.98	28.58	18	6190	1306	1739267
Restlessness	38.90	28.58	27	6181	4294	1736279
Orthostatic intolerance	38.10	28.58	10	6198	127	1740446
Disorientation	37.52	28.58	29	6179	5440	1735133
Gait inability	37.48	28.58	24	6184	3339	1737234
Intentional self-injury	37.24	28.58	22	6186	2651	1737922
Epistaxis	36.33	28.58	34	6174	8272	1732301
Blood ketone body increased	36.07	28.58	9	6199	92	1740481
Torsade de pointes	35.89	28.58	17	6191	1307	1739266
Foetal growth restriction	35.84	28.58	14	6194	670	1739903
Sleep disorder	35.67	28.58	25	6183	4038	1736535
Implant site extravasation	35.45	28.58	10	6198	169	1740404
Diabetic foetopathy	35.24	28.58	7	6201	21	1740552
Mitral valve incompetence	35.22	28.58	19	6189	1923	1738650
Ventricular hypokinesia	35.20	28.58	14	6194	703	1739870
Cardiomegaly	34.60	28.58	20	6188	2314	1738259
Arterial intramural haematoma	34.36	28.58	6	6202	6	1740567
Kounis syndrome	34.15	28.58	12	6196	425	1740148
Urinary tract infection	34.11	28.58	36	6172	10117	1730456
Serotonin syndrome	33.83	28.58	21	6187	2767	1737806
Onychomycosis	33.73	28.58	11	6197	309	1740264
Hypertensive crisis	33.58	28.58	17	6191	1510	1739063
Hot flush	33.14	28.58	20	6188	2505	1738068
Congenital cystic lung	33.11	28.58	7	6201	31	1740542
Respiratory failure	32.89	28.58	42	6166	14463	1726110
Acute respiratory failure	32.80	28.58	21	6187	2919	1737654
Hepatic steatosis	32.72	28.58	20	6188	2564	1738009
Cardiac disorder	32.71	28.58	31	6177	7660	1732913
Weight increased	32.48	28.58	37	6171	11320	1729253
Treatment noncompliance	32.28	28.58	26	6182	5175	1735398
Myalgia	31.88	28.58	43	6165	15615	1724958
Diabetes mellitus	31.61	28.58	29	6179	6879	1733694
Coronary artery occlusion	31.44	28.58	18	6190	2045	1738528
Congenital muscle absence	31.19	28.58	5	6203	1	1740572
Congenital vas deferens absence	31.19	28.58	5	6203	1	1740572
Hypoxia	31.18	28.58	27	6181	5936	1734637
Electrocardiogram abnormal	31.13	28.58	15	6193	1198	1739375
Musculoskeletal pain	30.72	28.58	25	6183	5049	1735524
Hypertensive emergency	30.34	28.58	9	6199	183	1740390
Product administration error	30.27	28.58	20	6188	2933	1737640
Congenital heart valve disorder	30.21	28.58	6	6202	18	1740555
Hydrops foetalis	30.16	28.58	7	6201	51	1740522
Arthralgia	30.16	28.58	52	6156	23392	1717181
Caesarean section	30.16	28.58	12	6196	603	1739970
Therapy non-responder	30.03	28.58	27	6181	6239	1734334
Bundle branch block left	29.96	28.58	13	6195	814	1739759
Wound dehiscence	29.95	28.58	12	6196	614	1739959
Haemorrhage	29.77	28.58	33	6175	9796	1730777
Dizziness postural	29.62	28.58	13	6195	837	1739736
Body temperature increased	29.57	28.58	19	6189	2658	1737915
Prostatomegaly	29.11	28.58	12	6196	661	1739912
Insomnia	29.11	28.58	42	6166	16234	1724339
Haemoglobin decreased	28.93	28.58	43	6165	17071	1723502
Blood pressure systolic decreased	28.76	28.58	12	6196	682	1739891
Product quality issue	28.70	28.58	26	6182	6067	1734506
Alcohol poisoning	28.67	28.58	11	6197	501	1740072
Cardiac flutter	28.65	28.58	10	6198	347	1740226

Pharmacologic Action:

Source	Code	Description
ATC	C07AB02	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, selective
ATC	C07BB02	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND THIAZIDES Beta blocking agents, selective, and thiazides
ATC	C07BB52	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND THIAZIDES Beta blocking agents, selective, and thiazides
ATC	C07CB02	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND OTHER DIURETICS Beta blocking agents, selective, and other diuretics
ATC	C07FB02	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers
ATC	C07FB13	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers
ATC	C07FX03	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations
ATC	C07FX05	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations
MeSH PA	D018663	Adrenergic Agents
FDA EPC	N0000175556	beta-Adrenergic Blocker
MeSH PA	D018674	Adrenergic Antagonists
MeSH PA	D058671	Adrenergic beta-1 Receptor Antagonists
MeSH PA	D000319	Adrenergic beta-Antagonists
CHEBI has role	CHEBI:35530	beta-adrenergic antagonist
CHEBI has role	CHEBI:35674	antihypertensive agent
MeSH PA	D000889	Anti-Arrhythmia Agents
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D013565	Sympatholytics

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Myocardial infarction	indication	22298006	DOID:5844
Hypertensive disorder	indication	38341003	DOID:10763
Chronic heart failure	indication	48447003
Angina pectoris	indication	194828000
Acute coronary syndrome	indication	394659003
Myocardial Reinfarction Prevention	indication
Supraventricular tachycardia	off-label use	6456007
Ventricular tachycardia	off-label use	25569003
Atrial fibrillation	off-label use	49436004	DOID:0060224
Multifocal atrial tachycardia	off-label use	49982000
Paroxysmal supraventricular tachycardia	off-label use	67198005
Thyrotoxicosis	off-label use	90739004	DOID:7997
Paroxysmal atrial tachycardia	off-label use	195069001
Ectopic atrial tachycardia	off-label use	233892002
Mitral valve prolapse	off-label use	409712001
Diastolic heart failure	off-label use	418304008	DOID:9775
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia	off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation	off-label use
Migraine Prevention	off-label use
Pheochromocytoma Adjunct Therapy	off-label use
Anuria	contraindication	2472002	DOID:2983
Bronchospasm	contraindication	4386001
Psoriasis	contraindication	9014002	DOID:8893
Hypercholesterolemia	contraindication	13644009
Secondary angle-closure glaucoma	contraindication	21571006
Complete atrioventricular block	contraindication	27885002
Hypovolemia	contraindication	28560003
Dehydration	contraindication	34095006
Depressive disorder	contraindication	35489007
Hyperuricemia	contraindication	35885006	DOID:1920
Sick sinus syndrome	contraindication	36083008	DOID:13884
Anaphylaxis	contraindication	39579001
Hypokalemia	contraindication	43339004
Low blood pressure	contraindication	45007003
Sinus bradycardia	contraindication	49710005
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Sympathectomy	contraindication	57071006
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Hypochloremic alkalosis	contraindication	70134007
Hepatic coma	contraindication	72836002	DOID:12550
Diabetes mellitus	contraindication	73211009	DOID:9351
Cardiogenic shock	contraindication	89138009
Hyponatremia	contraindication	89627008
Gout	contraindication	90560007	DOID:13189
Myasthenia gravis	contraindication	91637004	DOID:437
Hypomagnesemia	contraindication	190855004
Second degree atrioventricular block	contraindication	195042002
Decompensated cardiac failure	contraindication	195111005
Acute pancreatitis	contraindication	197456007	DOID:2913
Disease of liver	contraindication	235856003	DOID:409
Hypoglycemic disorder	contraindication	237630007
Raynaud's phenomenon	contraindication	266261006
Neonatal hyperbilirubinemia	contraindication	281610001
Pregnancy, function	contraindication	289908002
Pheochromocytoma	contraindication	302835009
Peripheral arterial occlusive disease	contraindication	399957001
Peripheral vascular disease	contraindication	400047006
Poor metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	423629005
Azotemia	contraindication	445009001
Acute exacerbation of asthma	contraindication	708038006
First Degree Atrioventricular Heart Block	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.19	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN	ANTAGONIST	Ki	7.60		WOMBAT-PK	CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	6.30		WOMBAT-PK
Adrenergic receptor beta	GPCR		ADRB1_RAT ADRB2_RAT ADRB3_RAT		IC50	6.30		CHEMBL
Beta-2 adrenergic receptor	GPCR		ADRB2_CAVPO		Kd	6.79		CHEMBL
Beta-1 adrenergic receptor	GPCR		B0FL73_CAVPO		Kd	7.83		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	5		CHEMBL

External reference:

ID	Source
C0350132	UMLSCUI
D00601	KEGG_DRUG
7092007	SNOMEDCT_US
4019836	VANDF
6918	RXNORM
372826007	SNOMEDCT_US
d00134	MMSL
003627	NDDF
CHEBI:6904	CHEBI
CHEMBL13	ChEMBL_ID
DB00264	DRUGBANK_ID
CHEMBL1200337	ChEMBL_ID
GEB06NHM23	UNII
3471	INN_ID
80274-67-5	SECONDARY_CAS_RN
4171	PUBCHEM_CID
D008790	MESH_DESCRIPTOR_UI
CHEMBL2062335	ChEMBL_ID
CHEMBL2356097	ChEMBL_ID
CHEMBL3989566	ChEMBL_ID
553	IUPHAR_LIGAND_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9660	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9873	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0018	TABLET, FILM COATED	25 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0032	TABLET, FILM COATED	50 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0047	TABLET, FILM COATED	100 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0424	TABLET	50 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0434	TABLET	100 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0445	TABLET	100 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0378-4593	TABLET, FILM COATED	37.50 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0378-4594	TABLET, FILM COATED	75 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1778	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0409-2285	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0462	TABLET, FILM COATED	50 mg	ORAL	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0463	TABLET, FILM COATED	100 mg	ORAL	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-3552	TABLET	50 mg	ORAL	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-3553	TABLET	100 mg	ORAL	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-6547	TABLET, FILM COATED	25 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8016	TABLET, FILM COATED	50 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8017	TABLET, FILM COATED	100 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8322	TABLET, FILM COATED	25 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6340	TABLET	25 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6341	TABLET	50 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6342	TABLET	100 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-124	TABLET	50 mg	ORAL	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-263	TABLET, FILM COATED	50 mg	ORAL	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-298	TABLET, FILM COATED	25 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-553	TABLET	100 mg	ORAL	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-879	TABLET, FILM COATED	50 mg	ORAL	ANDA	12 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	12634-771	TABLET, FILM COATED	50 mg	ORAL	ANDA	11 sections
Metoprolol Tartrate	HUMAN PRESCRIPTION DRUG LABEL	1	13107-062	TABLET, FILM COATED	25 mg	ORAL	ANDA	12 sections