metoprolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 1786 51384-51-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metoprolol fumarate
  • metoprolol
  • metoprolol succinate
  • beatrolol
  • metoprolol tartrate
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
  • Molecular weight: 267.37
  • Formula: C15H25NO3
  • CLOGP: 1.49
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 50.72
  • ALOGS: -2.82
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1000 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 24.95 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 13 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.88 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1978 FDA US PHARMS HOLDINGS I

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1061.15 9.89 1837 281416 87190 50234681
Cardiac failure congestive 820.64 9.89 1595 281658 82787 50239084
Atrial fibrillation 747.46 9.89 1715 281538 100030 50221841
Drug ineffective 608.24 9.89 2450 280803 816883 49504988
Pemphigus 601.33 9.89 15 283238 120151 50201720
Coronary artery disease 570.61 9.89 766 282487 28960 50292911
Synovitis 520.56 9.89 47 283206 123818 50198053
Systemic lupus erythematosus 516.03 9.89 84 283169 140538 50181333
Bradycardia 515.46 9.89 1124 282129 63302 50258569
Hand deformity 499.44 9.89 13 283240 100186 50221685
Contraindicated product administered 493.85 9.89 114 283139 148844 50173027
Glossodynia 452.03 9.89 57 283196 115512 50206359
Drug intolerance 415.51 9.89 369 282884 218735 50103136
Acute myocardial infarction 411.36 9.89 651 282602 28622 50293249
Anti-cyclic citrullinated peptide antibody positive 377.73 9.89 3 283250 70584 50251287
Completed suicide 365.58 9.89 1585 281668 130304 50191567
Treatment failure 364.33 9.89 157 283096 137480 50184391
Infusion related reaction 353.26 9.89 260 282993 169297 50152574
Arthropathy 347.68 9.89 228 283025 157678 50164193
Pericarditis 327.48 9.89 31 283222 78658 50243213
Cerebrovascular accident 317.25 9.89 1207 282046 93473 50228398
Joint swelling 311.92 9.89 560 282693 244726 50077145
Rheumatoid arthritis 293.61 9.89 424 282829 202126 50119745
Hypotension 289.78 9.89 2281 280972 233188 50088683
Therapeutic product effect decreased 278.96 9.89 212 283041 135838 50186033
Lower respiratory tract infection 272.67 9.89 96 283157 95105 50226766
Rheumatoid factor positive 254.10 9.89 5 283248 49854 50272017
Swelling 253.12 9.89 461 282792 200411 50121460
Maternal exposure during pregnancy 247.06 9.89 319 282934 159459 50162412
Hypersensitivity 243.42 9.89 526 282727 214635 50107236
Off label use 241.31 9.89 1611 281642 472815 49849056
Product prescribing error 235.67 9.89 422 282831 20539 50301332
Duodenal ulcer perforation 234.79 9.89 4 283249 45607 50276264
Dizziness 217.98 9.89 2924 280329 343445 49978426
Helicobacter infection 211.03 9.89 18 283235 49684 50272187
Syncope 208.85 9.89 1132 282121 101870 50220001
Wound 198.12 9.89 180 283073 105614 50216257
Pain 186.49 9.89 2210 281043 576693 49745178
Hepatic enzyme increased 179.53 9.89 308 282945 137072 50184799
Rash 177.34 9.89 1581 281672 435890 49885981
Folliculitis 175.70 9.89 11 283242 39214 50282657
Cardiac disorder 174.73 9.89 584 282669 42395 50279476
Alopecia 173.82 9.89 743 282510 244304 50077567
Muscle injury 173.74 9.89 8 283245 37103 50284768
Abdominal discomfort 166.34 9.89 699 282554 230942 50090929
Coronary artery bypass 165.58 9.89 122 283131 2171 50319700
Fall 162.71 9.89 2705 280548 332227 49989644
Gastrointestinal haemorrhage 161.76 9.89 825 282428 72496 50249375
Product use issue 157.91 9.89 379 282874 149096 50172775
Discomfort 157.74 9.89 226 283027 108154 50213717
Palpitations 154.23 9.89 981 282272 93525 50228346
Cardiogenic shock 147.91 9.89 292 282961 15307 50306564
Angina pectoris 147.24 9.89 399 282854 25789 50296082
Product monitoring error 139.27 9.89 119 283134 2645 50319226
Dyspnoea 137.22 9.89 4021 279232 543587 49778284
Pyrexia 133.29 9.89 1423 281830 378780 49943091
Arthralgia 131.81 9.89 1699 281554 437003 49884868
Coronary arterial stent insertion 129.86 9.89 112 283141 2522 50319349
Sinus bradycardia 125.26 9.89 247 283006 12936 50308935
Angina unstable 118.36 9.89 166 283087 6540 50315331
International normalised ratio increased 118.12 9.89 517 282736 42635 50279236
Haematochezia 117.02 9.89 488 282765 39394 50282477
Abortion spontaneous 116.38 9.89 44 283209 41728 50280143
Arrhythmia 116.34 9.89 429 282824 32703 50289168
Irritable bowel syndrome 116.22 9.89 72 283181 51369 50270502
Sleep disorder due to general medical condition, insomnia type 114.77 9.89 19 283234 31428 50290443
Exposure during pregnancy 112.44 9.89 327 282926 120688 50201183
General physical health deterioration 112.04 9.89 1255 281998 141179 50180692
Infection 109.13 9.89 547 282706 172407 50149464
Drug hypersensitivity 107.29 9.89 894 282359 250116 50071755
C-reactive protein abnormal 105.60 9.89 15 283238 27794 50294077
Renal failure 105.57 9.89 985 282268 105648 50216223
Cardiac failure 105.29 9.89 758 282495 75282 50246589
Dehydration 104.80 9.89 1309 281944 151140 50170731
Asthenia 101.96 9.89 2420 280833 316622 50005249
Death 101.85 9.89 2461 280792 322918 49998953
Cardiac arrest 101.84 9.89 809 282444 82842 50239029
Oedema peripheral 97.55 9.89 1330 281923 156631 50165240
Pregnancy 95.24 9.89 24 283229 29553 50292318
Febrile neutropenia 92.85 9.89 261 282992 97406 50224465
Sinusitis 92.00 9.89 568 282685 169990 50151881
Ventricular tachycardia 88.88 9.89 241 283012 15580 50306291
Blister 87.46 9.89 220 283033 85198 50236673
Blood pressure increased 85.50 9.89 1129 282124 132003 50189868
Drug interaction 82.73 9.89 1573 281680 198048 50123823
Blood loss anaemia 81.60 9.89 156 283097 7983 50313888
Musculoskeletal stiffness 81.21 9.89 406 282847 128075 50193796
Pulmonary oedema 81.02 9.89 510 282743 48428 50273443
Chest pain 80.34 9.89 1414 281839 175468 50146403
Blood pressure inadequately controlled 79.66 9.89 110 283143 4270 50317601
Acute kidney injury 79.32 9.89 1751 281502 226307 50095564
Gastrointestinal disorder 78.73 9.89 268 282985 94188 50227683
Ill-defined disorder 78.47 9.89 115 283138 54539 50267332
Hypertensive crisis 76.54 9.89 203 283050 12951 50308920
Hip arthroplasty 73.86 9.89 39 283214 30390 50291481
Suspected suicide 73.66 9.89 118 283135 5239 50316632
Neutropenia 72.58 9.89 507 282746 147458 50174413
Haemoglobin decreased 72.02 9.89 1055 282198 126161 50195710
Device expulsion 71.36 9.89 36 283217 28786 50293085
Medication error 69.22 9.89 391 282862 35713 50286158
Labelled drug-drug interaction medication error 68.54 9.89 169 283084 10308 50311563
Drug abuse 66.15 9.89 148 283105 59698 50262173
Anti-neutrophil cytoplasmic antibody positive vasculitis 65.98 9.89 73 283180 2249 50319622
Plasma cell myeloma 65.96 9.89 348 282905 30974 50290897
Nodal rhythm 65.42 9.89 61 283192 1526 50320345
Anaemia 65.40 9.89 1863 281390 250593 50071278
Product substitution issue 65.29 9.89 200 283053 13857 50308014
C-reactive protein increased 64.39 9.89 176 283077 66298 50255573
Blood creatinine increased 63.94 9.89 680 282573 75480 50246391
Interstitial lung disease 62.53 9.89 127 283126 53049 50268822
Coronary artery occlusion 62.33 9.89 133 283120 7370 50314501
Drug resistance 60.01 9.89 16 283237 18973 50302898
Product use in unapproved indication 59.70 9.89 391 282862 115428 50206443
Red blood cell sedimentation rate increased 58.75 9.89 47 283206 29369 50292502
Toxicity to various agents 58.06 9.89 1579 281674 210920 50110951
Ventricular fibrillation 57.47 9.89 159 283094 10400 50311471
Impaired healing 57.47 9.89 199 283054 69587 50252284
Ejection fraction 57.09 9.89 50 283203 1150 50320721
Unresponsive to stimuli 56.39 9.89 328 282925 30281 50291590
Sensitisation 56.14 9.89 56 283197 1526 50320345
Myocardial ischaemia 55.60 9.89 167 283086 11446 50310425
Diarrhoea 55.18 9.89 3911 279342 584565 49737306
Condition aggravated 54.96 9.89 1255 281998 295803 50026068
Hypertensive emergency 54.87 9.89 55 283198 1508 50320363
Chronic kidney disease 54.18 9.89 395 282858 39376 50282495
Atrial flutter 53.81 9.89 138 283115 8625 50313246
Inflammation 53.40 9.89 153 283100 56759 50265112
Pulmonary renal syndrome 52.71 9.89 31 283222 369 50321502
Therapeutic drug monitoring analysis not performed 52.01 9.89 38 283215 667 50321204
Suicidal ideation 51.89 9.89 149 283104 55236 50266635
Atrioventricular block 51.72 9.89 113 283140 6365 50315506
Mental status changes 51.00 9.89 363 282890 35909 50285962
Product administration error 50.87 9.89 232 283021 19467 50302404
BRASH syndrome 49.25 9.89 24 283229 189 50321682
Transient ischaemic attack 49.22 9.89 329 282924 31881 50289990
Orthostatic intolerance 49.06 9.89 42 283211 936 50320935
Drug reaction with eosinophilia and systemic symptoms 48.97 9.89 52 283201 28372 50293499
Presyncope 48.33 9.89 265 282988 23933 50297938
Nasopharyngitis 48.28 9.89 774 282479 192153 50129718
Lower gastrointestinal haemorrhage 48.25 9.89 114 283139 6765 50315106
Hyperkalaemia 46.94 9.89 443 282810 47646 50274225
Lactic acidosis 46.43 9.89 333 282920 33022 50288849
Pulmonary hypertension 46.15 9.89 333 282920 33084 50288787
Peripheral arterial occlusive disease 46.04 9.89 76 283177 3461 50318410
Ischaemic stroke 45.10 9.89 193 283060 15755 50306116
Bone erosion 45.09 9.89 6 283247 11681 50310190
Full blood count decreased 44.82 9.89 245 283008 22101 50299770
Heart rate increased 43.83 9.89 641 282612 76609 50245262
Atrioventricular block complete 43.26 9.89 113 283140 7142 50314729
Erythema 43.04 9.89 569 282684 145845 50176026
Renal impairment 42.60 9.89 627 282626 75034 50246837
Thrombosis 41.61 9.89 487 282766 55346 50266525
Migraine 41.43 9.89 249 283004 75031 50246840
Heart rate irregular 40.69 9.89 215 283038 19145 50302726
Stomatitis 40.52 9.89 367 282886 100977 50220894
Hepatic function abnormal 40.19 9.89 76 283177 32605 50289266
Acute coronary syndrome 39.53 9.89 129 283124 9245 50312626
Mobility decreased 39.14 9.89 274 282979 79674 50242197
Nephrogenic systemic fibrosis 38.69 9.89 79 283174 4243 50317628
Hypertension 38.57 9.89 1496 281757 209707 50112164
Abortion induced 38.02 9.89 4 283249 9340 50312531
Deep vein thrombosis 38.01 9.89 599 282654 72705 50249166
Intentional product use issue 37.96 9.89 263 282990 76655 50245216
Rheumatoid nodule 37.91 9.89 12 283241 12723 50309148
Blood pressure decreased 37.89 9.89 479 282774 55430 50266441
Ventricular extrasystoles 37.61 9.89 137 283116 10379 50311492
Blood test abnormal 37.60 9.89 144 283109 11175 50310696
Atrioventricular block first degree 37.40 9.89 97 283156 6104 50315767
Mitral valve incompetence 37.39 9.89 195 283058 17276 50304595
Heart rate decreased 37.02 9.89 339 282914 36158 50285713
Injection site pain 36.96 9.89 420 282833 110604 50211267
Urticaria 36.81 9.89 507 282746 129054 50192817
Hyponatraemia 36.53 9.89 748 282505 95391 50226480
Cerebral haemorrhage 36.45 9.89 268 282985 26784 50295087
Knee arthroplasty 36.15 9.89 93 283160 35753 50286118
Decorticate posture 36.08 9.89 22 283231 281 50321590
Cardiac output decreased 35.96 9.89 34 283219 866 50321005
Live birth 35.64 9.89 24 283229 16384 50305487
Coronary artery stenosis 35.59 9.89 76 283177 4213 50317658
Tachyarrhythmia 35.53 9.89 74 283179 4031 50317840
Renal injury 34.97 9.89 117 283136 8494 50313377
Headache 34.93 9.89 2404 280849 504131 49817740
Myocardial depression 34.90 9.89 25 283228 425 50321446
Sopor 34.66 9.89 36 283217 19843 50302028
Drug tolerance decreased 34.64 9.89 5 283248 9155 50312716
Polycystic ovaries 34.54 9.89 55 283198 2429 50319442
Vascular graft 34.44 9.89 31 283222 740 50321131
Congenital hydronephrosis 34.42 9.89 24 283229 390 50321481
Intestinal malrotation 34.27 9.89 23 283230 350 50321521
Dyspnoea exertional 33.48 9.89 436 282817 50797 50271074
Hypomagnesaemia 33.28 9.89 233 283020 22923 50298948
Supraventricular tachycardia 33.23 9.89 151 283102 12650 50309221
Hypoglycaemia 32.95 9.89 451 282802 53130 50268741
Pruritus 32.90 9.89 1276 281977 282292 50039579
Intentional self-injury 32.81 9.89 49 283204 23063 50298808
Hip fracture 32.75 9.89 253 283000 25678 50296193
Congenital aortic valve stenosis 32.39 9.89 13 283240 60 50321811
Haemophagocytic lymphohistiocytosis 31.98 9.89 5 283248 8628 50313243
Anaphylactic reaction 31.78 9.89 175 283078 53880 50267991
Neutropenic sepsis 31.67 9.89 20 283233 14127 50307744
Drug eruption 31.65 9.89 52 283201 23554 50298317
Injection site reaction 31.64 9.89 158 283095 49874 50271997
Acute respiratory failure 31.59 9.89 272 282981 28510 50293361
Product dose omission issue 31.42 9.89 1293 281960 182545 50139326
Hepatocellular injury 31.33 9.89 61 283192 25886 50295985
Gout 31.05 9.89 137 283116 11333 50310538
Internal haemorrhage 30.77 9.89 73 283180 4344 50317527
Haematoma 30.74 9.89 283 282970 30227 50291644
Hypervolaemia 30.67 9.89 246 283007 25253 50296618
Urinary tract infection 30.55 9.89 1540 281713 222480 50099391
Heart rate abnormal 30.03 9.89 68 283185 3924 50317947
Epistaxis 29.97 9.89 514 282739 63440 50258431
Hypothermia 29.90 9.89 140 283113 11876 50309995
Pneumocystis jirovecii pneumonia 29.82 9.89 23 283230 14640 50307231
Torsade de pointes 29.53 9.89 138 283115 11697 50310174
Listless 29.30 9.89 50 283203 2340 50319531
Bradyarrhythmia 29.30 9.89 44 283209 1846 50320025
Bundle branch block left 29.27 9.89 89 283164 6141 50315730
Cardiovascular disorder 29.17 9.89 126 283127 10328 50311543
Cardiac failure acute 29.10 9.89 107 283146 8143 50313728
Loss of employment 29.09 9.89 40 283213 1546 50320325
Ventricular arrhythmia 29.05 9.89 60 283193 3249 50318622
Cytomegalovirus infection 28.62 9.89 35 283218 17927 50303944
Wrong product administered 28.47 9.89 80 283173 5280 50316591
Blood potassium decreased 28.30 9.89 324 282929 36621 50285250
Tendonitis 28.29 9.89 31 283222 16674 50305197
Device capturing issue 28.22 9.89 10 283243 30 50321841
Skin induration 28.21 9.89 55 283198 2856 50319015
Angioedema 27.79 9.89 328 282925 37348 50284523
Renal disorder 27.65 9.89 255 282998 27250 50294621
Bone marrow failure 27.60 9.89 72 283181 27552 50294319
Conjoined twins 27.51 9.89 18 283235 262 50321609
Lymphocyte count decreased 27.50 9.89 67 283186 26240 50295631
Arteriosclerosis 27.35 9.89 112 283141 8965 50312906
Cardiac pacemaker insertion 27.23 9.89 62 283191 3591 50318280
Hiatus hernia 27.20 9.89 186 283067 18158 50303713
Acute left ventricular failure 27.20 9.89 28 283225 793 50321078
Panniculitis 27.18 9.89 7 283246 8496 50313375
Therapeutic product effect incomplete 27.11 9.89 355 282898 91160 50230711
Blood glucose increased 27.11 9.89 555 282698 70769 50251102
Type 2 diabetes mellitus 26.98 9.89 100 283153 34275 50287596
Allergic reaction to excipient 26.93 9.89 18 283235 272 50321599
Pallor 26.92 9.89 222 283031 22977 50298894
Cardiomegaly 26.90 9.89 167 283086 15778 50306093
Body temperature increased 26.73 9.89 88 283165 31253 50290618
Arterial haemorrhage 26.67 9.89 38 283215 1519 50320352
Ischaemic cardiomyopathy 26.56 9.89 47 283206 2265 50319606
Sedation complication 26.56 9.89 8 283245 8758 50313113
Mucosal inflammation 26.41 9.89 125 283128 40017 50281854
Therapy non-responder 26.40 9.89 172 283081 50850 50271021
Nodal arrhythmia 26.34 9.89 32 283221 1092 50320779
Aortic valve stenosis 26.18 9.89 54 283199 2921 50318950
Electrocardiogram T wave abnormal 26.14 9.89 46 283207 2207 50319664
Body height decreased 26.12 9.89 109 283144 8799 50313072
Blood urea increased 25.94 9.89 223 283030 23362 50298509
Injection site erythema 25.92 9.89 281 282972 74655 50247216
Hypertensive heart disease 25.89 9.89 46 283207 2224 50319647
Acute generalised exanthematous pustulosis 25.59 9.89 9 283244 8929 50312942
Therapeutic response decreased 25.58 9.89 157 283096 47074 50274797
Fluid retention 25.54 9.89 412 282841 50237 50271634
Aortic valve incompetence 25.51 9.89 78 283175 5398 50316473
Pleural effusion 25.34 9.89 616 282637 80838 50241033
Dystonia 25.17 9.89 18 283235 11908 50309963
Body tinea 25.15 9.89 34 283219 1293 50320578
Nephrectomy 25.03 9.89 27 283226 808 50321063
Device dislocation 24.86 9.89 52 283201 21494 50300377
Decreased appetite 24.52 9.89 1367 281886 199556 50122315
Venous pressure jugular increased 24.38 9.89 22 283231 527 50321344
Infective pulmonary exacerbation of cystic fibrosis 24.36 9.89 7 283246 7902 50313969
Electrolyte imbalance 24.23 9.89 172 283081 16997 50304874
Tachycardia 24.07 9.89 730 282523 99033 50222838
Heparin-induced thrombocytopenia 23.89 9.89 62 283191 3903 50317968
Product solubility abnormal 23.70 9.89 25 283228 729 50321142
Glomerular filtration rate decreased 23.53 9.89 128 283125 11524 50310347
Hepatotoxicity 23.53 9.89 76 283177 27150 50294721
Haemarthrosis 23.53 9.89 51 283202 2857 50319014
Immunodeficiency 23.51 9.89 29 283224 14799 50307072
Progressive multifocal leukoencephalopathy 23.26 9.89 18 283235 11439 50310432
Gastrointestinal tract mucosal pigmentation 23.22 9.89 22 283231 562 50321309
Labile hypertension 23.16 9.89 20 283233 451 50321420
Asthma 23.13 9.89 356 282897 88981 50232890
Diverticulum intestinal haemorrhagic 22.93 9.89 31 283222 1179 50320692
Vitello-intestinal duct remnant 22.87 9.89 9 283244 39 50321832
Cardiac ablation 22.79 9.89 32 283221 1262 50320609
Intraventricular haemorrhage 22.77 9.89 39 283214 1831 50320040
Troponin increased 22.77 9.89 98 283155 8020 50313851
Coronary artery dissection 22.66 9.89 24 283229 703 50321168
Rhabdomyolysis 22.58 9.89 325 282928 38702 50283169
Sudden cardiac death 22.54 9.89 40 283213 1932 50319939
Hepatitis 22.46 9.89 95 283158 31358 50290513
Granuloma skin 22.41 9.89 3 283250 5815 50316056
Lymphopenia 22.29 9.89 33 283220 15588 50306283
Atrioventricular block second degree 22.21 9.89 57 283196 3564 50318307
Muscle spasticity 21.99 9.89 39 283214 17145 50304726
Ageusia 21.90 9.89 125 283128 11458 50310413
Rhinitis allergic 21.82 9.89 89 283164 7111 50314760
Myxoedema coma 21.80 9.89 18 283235 381 50321490
Ventricular hypokinesia 21.73 9.89 60 283193 3920 50317951
Psoriatic arthropathy 21.66 9.89 164 283089 46868 50275003
Blue toe syndrome 21.52 9.89 18 283235 388 50321483
Electrocardiogram abnormal 21.48 9.89 92 283161 7513 50314358
Gouty arthritis 21.46 9.89 20 283233 500 50321371
Neutrophil count decreased 21.43 9.89 160 283093 45866 50276005
Non-cardiogenic pulmonary oedema 21.42 9.89 21 283232 560 50321311
Subchondral insufficiency fracture 21.38 9.89 9 283244 48 50321823
Cardiomyopathy 21.34 9.89 155 283098 15431 50306440
Rash maculo-papular 21.24 9.89 77 283176 26564 50295307
CD30 expression 21.23 9.89 8 283245 30 50321841
Cholestasis 21.20 9.89 72 283181 25329 50296542
Glucose tolerance impaired 21.19 9.89 70 283183 5048 50316823
Vascular resistance pulmonary decreased 21.16 9.89 10 283243 73 50321798
Weight increased 21.14 9.89 919 282334 200972 50120899
Anuria 21.04 9.89 121 283132 11123 50310748
Congenital bladder anomaly 20.99 9.89 13 283240 171 50321700
Poisoning deliberate 20.95 9.89 9 283244 7903 50313968
Bicuspid aortic valve 20.87 9.89 11 283242 104 50321767
Phaeochromocytoma crisis 20.87 9.89 14 283239 213 50321658
Chloropsia 20.83 9.89 8 283245 32 50321839
Eructation 20.77 9.89 87 283166 7034 50314837
End stage renal disease 20.74 9.89 75 283178 5662 50316209
Renal impairment neonatal 20.64 9.89 8 283245 33 50321838
Respiratory disorder 20.58 9.89 97 283156 31090 50290781
Atrial septal defect 20.51 9.89 80 283173 6261 50315610
Cerebrospinal fluid retention 20.49 9.89 10 283243 79 50321792
Urachal abnormality 20.48 9.89 13 283240 179 50321692
Rectourethral fistula 20.45 9.89 8 283245 34 50321837
Pharyngitis 20.40 9.89 42 283211 17461 50304410
Haemorrhage 20.36 9.89 416 282837 53025 50268846
Osmolar gap increased 20.26 9.89 7 283246 19 50321852
Splenic rupture 20.17 9.89 29 283224 1169 50320702
Dementia 20.15 9.89 156 283097 15841 50306030
Liver disorder 20.01 9.89 124 283129 37098 50284773
Hyperthermia 19.99 9.89 9 283244 7687 50314184
Arrhythmia neonatal 19.92 9.89 8 283245 37 50321834
Coagulopathy 19.91 9.89 170 283083 17774 50304097
Device stimulation issue 19.85 9.89 9 283244 59 50321812
Bronchiectasis 19.83 9.89 17 283236 10266 50311605
Mouth ulceration 19.79 9.89 85 283168 27939 50293932
Arteriosclerosis coronary artery 19.76 9.89 90 283163 7546 50314325
Fryns syndrome 19.72 9.89 9 283244 60 50321811
Persistent cloaca 19.70 9.89 13 283240 192 50321679
Cardioversion 19.70 9.89 28 283225 1117 50320754
Atrial thrombosis 19.58 9.89 32 283221 1445 50320426
Pulseless electrical activity 19.51 9.89 83 283170 6758 50315113
Embolic stroke 19.49 9.89 53 283200 3431 50318440
Haematuria 19.34 9.89 224 283029 25389 50296482
Diverticulum intestinal 19.31 9.89 75 283178 5858 50316013
International normalised ratio decreased 19.25 9.89 59 283194 4089 50317782
Sedation 19.16 9.89 97 283156 30513 50291358
Amenorrhoea 18.98 9.89 12 283241 8472 50313399
Blood parathyroid hormone decreased 18.98 9.89 8 283245 7106 50314765
Fear 18.96 9.89 143 283110 14406 50307465
Embolic cerebral infarction 18.92 9.89 18 283235 462 50321409
Acne 18.88 9.89 52 283201 19543 50302328
Schizophrenia 18.67 9.89 9 283244 7388 50314483
Orthopnoea 18.59 9.89 72 283181 5617 50316254
Congenital choroid plexus cyst 18.47 9.89 15 283238 310 50321561
Malignant polyp 18.38 9.89 12 283241 174 50321697
Patent ductus arteriosus 18.35 9.89 55 283198 3765 50318106
Post procedural haemorrhage 18.31 9.89 85 283168 7185 50314686
Device difficult to use 18.27 9.89 17 283236 9869 50312002
Blood pressure abnormal 18.16 9.89 128 283125 12619 50309252
Congenital acrochordon 18.09 9.89 8 283245 49 50321822
Atrial tachycardia 17.95 9.89 38 283215 2094 50319777
Myelosuppression 17.91 9.89 30 283223 13487 50308384
Grip strength decreased 17.89 9.89 25 283228 12096 50309775
Inhibitory drug interaction 17.88 9.89 39 283214 2194 50319677
Haemorrhoidal haemorrhage 17.81 9.89 53 283200 3614 50318257
Product residue present 17.76 9.89 53 283200 3619 50318252
Blood albumin abnormal 17.76 9.89 17 283236 440 50321431
Foot deformity 17.75 9.89 52 283201 19158 50302713
Cardiac valve disease 17.70 9.89 54 283199 3732 50318139
Ovarian cyst 17.69 9.89 32 283221 13964 50307907
Ultrasound kidney abnormal 17.67 9.89 7 283246 31 50321840
Head injury 17.66 9.89 209 283044 23811 50298060
Sinus arrest 17.58 9.89 33 283220 1665 50320206
Degenerative aortic valve disease 17.55 9.89 9 283244 80 50321791
Malignant neoplasm progression 17.45 9.89 272 282981 67852 50254019
Myocardial necrosis marker increased 17.44 9.89 31 283222 1499 50320372
Neutrophil function disorder 17.44 9.89 6 283247 16 50321855
Serotonin syndrome 17.42 9.89 75 283178 24638 50297233
Phaeochromocytoma 17.41 9.89 17 283236 451 50321420
Hypokalaemia 17.40 9.89 629 282624 87363 50234508
Sinus node dysfunction 17.19 9.89 55 283198 3900 50317971
Metastases to bone 17.15 9.89 48 283205 17947 50303924
Coma 17.08 9.89 220 283033 56659 50265212
Subarachnoid haemorrhage 17.02 9.89 111 283142 10665 50311206
Lymphatic fistula 17.01 9.89 21 283232 729 50321142
Extrasystoles 16.95 9.89 61 283192 4594 50317277
Hyperammonaemia 16.91 9.89 3 283250 4721 50317150
Haemorrhage intracranial 16.91 9.89 123 283130 12251 50309620
Aortic aneurysm 16.81 9.89 48 283205 3197 50318674
Negative cardiac inotropic effect 16.76 9.89 4 283249 0 50321871
Adrenalectomy 16.76 9.89 4 283249 0 50321871
Femoral hernia incarcerated 16.76 9.89 21 283232 740 50321131
Unevaluable event 16.70 9.89 356 282897 45710 50276161
Electrocardiogram T wave inversion 16.67 9.89 48 283205 3213 50318658
Left-to-right cardiac shunt 16.58 9.89 10 283243 125 50321746
Chronic obstructive pulmonary disease 16.58 9.89 404 282849 53031 50268840
Congenital nail disorder 16.56 9.89 9 283244 91 50321780
Hypovolaemia 16.51 9.89 100 283153 9365 50312506
Arteriovenous fistula occlusion 16.46 9.89 15 283238 364 50321507
Liver injury 16.46 9.89 77 283176 24729 50297142
Anhedonia 16.22 9.89 100 283153 9424 50312447
Aortic stenosis 16.16 9.89 56 283197 4138 50317733
Drug level increased 16.14 9.89 172 283081 19096 50302775
Flatulence 16.13 9.89 243 283010 29215 50292656
Cardiac operation 16.12 9.89 43 283210 2752 50319119
Stent placement 16.04 9.89 49 283204 3389 50318482
Hyperlipidaemia 16.02 9.89 159 283094 17331 50304540
Cerebral infarction 15.89 9.89 188 283065 21416 50300455
Aortic valve sclerosis 15.82 9.89 24 283229 1016 50320855
Tuberculosis 15.69 9.89 20 283233 10063 50311808
Renal function test abnormal 15.60 9.89 43 283210 2806 50319065
Poor venous access 15.59 9.89 21 283232 10319 50311552
Drug therapeutic incompatibility 15.55 9.89 7 283246 45 50321826
Product quality issue 15.55 9.89 251 283002 30607 50291264
Hypocapnia 15.53 9.89 14 283239 335 50321536
Neonatal respiratory failure 15.46 9.89 11 283242 185 50321686
Occult blood positive 15.45 9.89 47 283206 3244 50318627
Shock 15.32 9.89 180 283073 20470 50301401
Foreign body 15.30 9.89 34 283219 1937 50319934
Traumatic haemorrhage 15.29 9.89 16 283237 462 50321409
Skin hypertrophy 15.28 9.89 45 283208 3050 50318821
Pneumonia 15.23 9.89 2376 280877 376025 49945846
Therapy partial responder 15.20 9.89 9 283244 6582 50315289
Cardioactive drug level increased 15.15 9.89 34 283219 1950 50319921
Renal dysplasia 15.14 9.89 10 283243 148 50321723
Sleep apnoea syndrome 15.12 9.89 202 283051 23666 50298205
Enterocolitis 15.10 9.89 9 283244 6558 50315313
Ejection fraction abnormal 15.00 9.89 21 283232 826 50321045
Carotid artery occlusion 14.94 9.89 39 283214 2464 50319407
Pancreatic steatosis 14.93 9.89 22 283231 907 50320964
Oesophagitis chemical 14.90 9.89 5 283248 12 50321859
Hypoacusis 14.89 9.89 179 283074 20468 50301403
Graft versus host disease 14.82 9.89 8 283245 6158 50315713
Electrocardiogram QRS complex shortened 14.74 9.89 15 283238 419 50321452
Alanine aminotransferase increased 14.72 9.89 379 282874 87980 50233891
Injection site swelling 14.70 9.89 156 283097 41617 50280254
Pulmonary tuberculosis 14.69 9.89 3 283250 4270 50317601
Ischaemic hepatitis 14.67 9.89 33 283220 1896 50319975
Gastrointestinal toxicity 14.67 9.89 4 283249 4673 50317198
Supraventricular extrasystoles 14.63 9.89 52 283201 3892 50317979
Alpha hydroxybutyrate dehydrogenase increased 14.62 9.89 5 283248 13 50321858
Congenital diaphragmatic hernia 14.59 9.89 11 283242 203 50321668
Fear of injection 14.55 9.89 8 283245 6095 50315776
Cardiac valve abscess 14.54 9.89 4 283249 3 50321868
Hypoxia 14.53 9.89 382 282871 50741 50271130
Agranulocytosis 14.50 9.89 66 283187 21355 50300516
Melaena 14.48 9.89 221 283032 26643 50295228
Lacunar infarction 14.41 9.89 44 283209 3043 50318828
Tooth erosion 14.26 9.89 15 283238 436 50321435
Pathogen resistance 14.24 9.89 7 283246 5682 50316189
Pulse absent 14.24 9.89 59 283194 4747 50317124
Mitral valve sclerosis 14.24 9.89 9 283244 123 50321748
Injection site pruritus 14.18 9.89 151 283102 40260 50281611
Mood swings 14.16 9.89 44 283209 15910 50305961
Pseudolymphoma 14.16 9.89 17 283236 573 50321298
Haematotoxicity 14.10 9.89 14 283239 7881 50313990
Dysphagia 14.10 9.89 549 282704 76969 50244902
QRS axis abnormal 14.08 9.89 22 283231 956 50320915
Glomerulonephritis rapidly progressive 14.05 9.89 20 283233 799 50321072
Left ventricular hypertrophy 13.98 9.89 59 283194 4786 50317085
Hepatic cyst 13.98 9.89 56 283197 4437 50317434
Ischaemic cerebral infarction 13.98 9.89 24 283229 1129 50320742
Blood cholesterol increased 13.96 9.89 221 283032 54994 50266877
Haemorrhagic erosive gastritis 13.92 9.89 12 283241 270 50321601
Colitis ulcerative 13.91 9.89 48 283205 16806 50305065
Aortic valve disease 13.89 9.89 21 283232 886 50320985
Gastric ulcer 13.78 9.89 181 283072 21124 50300747
Cardiac fibrillation 13.77 9.89 15 283238 454 50321417
Optic neuritis 13.77 9.89 11 283242 6879 50314992
Coeliac disease 13.75 9.89 17 283236 8668 50313203
Pregnancy with contraceptive device 13.74 9.89 3 283250 4076 50317795
Muscle spasms 13.73 9.89 846 282407 124707 50197164
Arteriospasm coronary 13.62 9.89 46 283207 3356 50318515
Chromaturia 13.54 9.89 133 283120 14457 50307414
Mitral valve stenosis 13.48 9.89 22 283231 992 50320879
Pericardial haemorrhage 13.47 9.89 27 283226 1431 50320440
Loss of personal independence in daily activities 13.46 9.89 294 282959 69756 50252115
Cerebral artery occlusion 13.30 9.89 20 283233 840 50321031
Stent malfunction 13.30 9.89 7 283246 66 50321805
Computerised tomogram head abnormal 13.13 9.89 4 283249 6 50321865
Thrombin time prolonged 13.13 9.89 8 283245 102 50321769
Vanishing bile duct syndrome 13.12 9.89 17 283236 620 50321251
Aneurysm 13.11 9.89 37 283216 2448 50319423
Faeces discoloured 13.07 9.89 143 283110 15981 50305890
Respiratory failure 13.06 9.89 630 282623 90551 50231320
Splenic haemorrhage 12.97 9.89 10 283243 191 50321680
Epstein-Barr virus infection 12.97 9.89 12 283241 6985 50314886
Dysgeusia 12.92 9.89 297 282956 38619 50283252
Eosinophilia 12.91 9.89 57 283196 18595 50303276
Complication of device insertion 12.90 9.89 9 283244 6032 50315839
Peritonitis bacterial 12.87 9.89 56 283197 4605 50317266
Cerebral ventricular rupture 12.84 9.89 10 283243 194 50321677
Demyelination 12.84 9.89 9 283244 6017 50315854
Lung disorder 12.82 9.89 175 283078 44624 50277247
Hypothyroidism 12.78 9.89 265 282988 33860 50288011
Hypoaldosteronism 12.77 9.89 9 283244 149 50321722
Fibromyalgia 12.76 9.89 176 283077 44802 50277069
Hospice care 12.75 9.89 65 283188 5707 50316164
Neuroleptic malignant syndrome 12.73 9.89 27 283226 11103 50310768
Electrocardiogram QT interval abnormal 12.71 9.89 9 283244 150 50321721
Ear infection 12.71 9.89 89 283164 25881 50295990
Ventricular tachyarrhythmia 12.69 9.89 7 283246 73 50321798
Calciphylaxis 12.69 9.89 38 283215 2600 50319271
Intentional underdose 12.62 9.89 28 283225 1594 50320277
Foetal renal impairment 12.57 9.89 3 283250 0 50321871
Aortic aneurysm repair 12.57 9.89 3 283250 0 50321871
Electrocardiogram RR interval prolonged 12.57 9.89 3 283250 0 50321871
Diabetic enteropathy 12.57 9.89 3 283250 0 50321871
Photophobia 12.56 9.89 42 283211 14845 50307026
Malignant hypertension 12.55 9.89 22 283231 1052 50320819
Capillary disorder 12.53 9.89 7 283246 75 50321796
Retroperitoneal haemorrhage 12.47 9.89 37 283216 2519 50319352
Ankylosing spondylitis 12.46 9.89 13 283240 7152 50314719
Dialysis 12.43 9.89 93 283160 9345 50312526
Carotid artery stenosis 12.42 9.89 56 283197 4675 50317196
Myocardial hypoxia 12.42 9.89 4 283249 8 50321863
Cyanopsia 12.42 9.89 4 283249 8 50321863
Device use error 12.41 9.89 7 283246 5259 50316612
Rectal haemorrhage 12.41 9.89 293 282960 38265 50283606
Feeling abnormal 12.35 9.89 838 282415 124654 50197217
Haemorrhagic stroke 12.35 9.89 60 283193 5168 50316703
Sleep disorder 12.32 9.89 236 283017 57047 50264824
HELLP syndrome 12.30 9.89 20 283233 899 50320972
Post-anoxic myoclonus 12.30 9.89 5 283248 24 50321847
Lymphadenopathy 12.24 9.89 124 283129 33375 50288496
Fracture blisters 12.22 9.89 7 283246 79 50321792
Diet noncompliance 12.21 9.89 11 283242 263 50321608
Cardiac discomfort 12.20 9.89 19 283234 823 50321048
Tracheo-oesophageal fistula 12.19 9.89 15 283238 519 50321352
Gastritis erosive 12.18 9.89 59 283194 5075 50316796
Circulatory collapse 12.15 9.89 168 283085 19832 50302039
Congenital uterine anomaly 12.13 9.89 8 283245 118 50321753
Thrombotic microangiopathy 12.13 9.89 19 283234 8772 50313099
Menstruation irregular 12.11 9.89 10 283243 6152 50315719
Antithyroid arthritis syndrome 12.10 9.89 4 283249 9 50321862
Spinal cord haematoma 12.08 9.89 9 283244 163 50321708
Embolism arterial 12.02 9.89 19 283234 834 50321037
Brain contusion 12.01 9.89 15 283238 527 50321344
Blood pressure immeasurable 12.00 9.89 22 283231 1090 50320781
Blood magnesium decreased 12 9.89 105 283148 11055 50310816
Essential hypertension 11.97 9.89 53 283200 4391 50317480
Kyphosis 11.94 9.89 34 283219 2261 50319610
Angiocardiogram 11.92 9.89 6 283247 51 50321820
Bronchopulmonary aspergillosis 11.88 9.89 15 283238 7577 50314294
Aphthous ulcer 11.87 9.89 26 283227 10571 50311300
Palmar-plantar erythrodysaesthesia syndrome 11.85 9.89 65 283188 20033 50301838
Epinephrine increased 11.81 9.89 4 283249 10 50321861
Disease recurrence 11.81 9.89 65 283188 20016 50301855
Embolism venous 11.79 9.89 36 283217 2489 50319382
Food allergy 11.79 9.89 17 283236 8120 50313751
Skin tightness 11.79 9.89 47 283206 3716 50318155
Blood potassium increased 11.76 9.89 142 283111 16256 50305615
Subclavian vein thrombosis 11.75 9.89 29 283224 1770 50320101
Tachycardia induced cardiomyopathy 11.73 9.89 6 283247 53 50321818
Alveolitis 11.72 9.89 36 283217 2498 50319373
Gastrointestinal arteriovenous malformation 11.70 9.89 15 283238 541 50321330
Peripheral vascular disorder 11.68 9.89 61 283192 5406 50316465
Electrocardiogram QRS complex prolonged 11.68 9.89 60 283193 5284 50316587
Genital labial adhesions 11.68 9.89 5 283248 28 50321843
Pulmonary hypoplasia 11.67 9.89 11 283242 279 50321592
Renal aplasia 11.60 9.89 10 283243 225 50321646
Cardio-respiratory arrest 11.59 9.89 389 282864 53503 50268368
Gastroenteritis clostridial 11.58 9.89 15 283238 547 50321324
Echocardiogram abnormal 11.54 9.89 22 283231 1123 50320748
Ulcer 11.54 9.89 66 283187 20134 50301737
Positron emission tomogram abnormal 11.54 9.89 9 283244 175 50321696
Hypoperfusion 11.54 9.89 24 283229 1306 50320565
Blood electrolytes decreased 11.53 9.89 21 283232 1035 50320836
Arterial stent insertion 11.53 9.89 5 283248 29 50321842
Maternal exposure timing unspecified 11.53 9.89 3 283250 3617 50318254
Rash erythematous 11.53 9.89 132 283121 34720 50287151
Polyhydramnios 11.53 9.89 31 283222 1994 50319877
Epilepsy 11.51 9.89 72 283181 21495 50300376
Hypogammaglobulinaemia 11.51 9.89 9 283244 5690 50316181
Coronary artery restenosis 11.51 9.89 12 283241 345 50321526
Disability 11.50 9.89 35 283218 12740 50309131
Head discomfort 11.50 9.89 103 283150 10916 50310955
Hypertransaminasaemia 11.49 9.89 3 283250 3608 50318263
Ear pain 11.48 9.89 102 283151 28181 50293690
Non-high-density lipoprotein cholesterol increased 11.47 9.89 8 283245 130 50321741
Aortic arteriosclerosis 11.47 9.89 60 283193 5322 50316549
Multiple drug therapy 11.38 9.89 30 283223 1907 50319964
Urinary retention 11.37 9.89 208 283045 25982 50295889
Haemodialysis 11.35 9.89 83 283170 8279 50313592
Seroma 11.31 9.89 29 283224 1812 50320059
Infection susceptibility increased 11.29 9.89 36 283217 2548 50319323
Urogenital haemorrhage 11.28 9.89 10 283243 234 50321637
Blood pressure systolic abnormal 11.27 9.89 16 283237 7690 50314181
Septic shock 11.26 9.89 239 283014 56936 50264935
Conjunctival cyst 11.18 9.89 6 283247 59 50321812
Myxoedema 11.18 9.89 7 283246 94 50321777
Central nervous system injury 11.17 9.89 8 283245 136 50321735
Mydriasis 11.16 9.89 27 283226 10600 50311271
Vascular stent thrombosis 11.12 9.89 19 283234 890 50320981
Systemic infection 11.09 9.89 33 283220 2250 50319621
Arrhythmia supraventricular 11.03 9.89 19 283234 896 50320975
Prothrombin time prolonged 11.03 9.89 86 283167 8752 50313119
Product name confusion 11.01 9.89 6 283247 61 50321810
Splenic injury 11.00 9.89 9 283244 188 50321683
Basal cell carcinoma 10.96 9.89 81 283172 23275 50298596
Leukopenia 10.89 9.89 291 282962 67237 50254634
Peripheral artery thrombosis 10.88 9.89 27 283226 1653 50320218
Oropharyngeal pain 10.86 9.89 342 282911 77459 50244412
Metabolic encephalopathy 10.85 9.89 57 283196 5064 50316807
Duplicate therapy error 10.85 9.89 6 283247 63 50321808
Therapeutic product effect increased 10.84 9.89 20 283233 996 50320875
Optic ischaemic neuropathy 10.83 9.89 20 283233 997 50320874
Haemorrhagic transformation stroke 10.80 9.89 21 283232 1088 50320783
Immune reconstitution inflammatory syndrome 10.78 9.89 9 283244 5507 50316364
Rabbit syndrome 10.76 9.89 11 283242 309 50321562
Uterine perforation 10.76 9.89 12 283241 6403 50315468
Injection site bruising 10.75 9.89 143 283110 36625 50285246
Reduced facial expression 10.73 9.89 26 283227 1568 50320303
Aspiration pleural cavity 10.72 9.89 17 283236 748 50321123
Hypochromic anaemia 10.72 9.89 27 283226 1669 50320202
Respiratory tract congestion 10.69 9.89 42 283211 14157 50307714
Gastric cyst 10.69 9.89 7 283246 102 50321769
Urosepsis 10.69 9.89 133 283120 15332 50306539
Eye haemorrhage 10.65 9.89 74 283179 7261 50314610
Blood sodium decreased 10.65 9.89 172 283081 20975 50300896
Hypomania 10.60 9.89 6 283247 4499 50317372
Therapeutic drug monitoring analysis incorrectly performed 10.55 9.89 8 283245 149 50321722
Chemical burn of oral cavity 10.53 9.89 6 283247 67 50321804
Brain stem infarction 10.52 9.89 17 283236 760 50321111
Intra-aortic balloon placement 10.51 9.89 3 283250 3 50321868
Pacemaker syndrome 10.51 9.89 3 283250 3 50321868
Diverticulum 10.46 9.89 98 283155 10516 50311355
Nervousness 10.45 9.89 215 283038 27436 50294435
Heavy menstrual bleeding 10.44 9.89 48 283205 15489 50306382
Dyschromatopsia 10.44 9.89 12 283241 386 50321485
Lacrimal gland enlargement 10.42 9.89 4 283249 16 50321855
Extra dose administered 10.41 9.89 56 283197 5020 50316851
Anaphylactic shock 10.39 9.89 68 283185 20087 50301784
Amaurosis fugax 10.36 9.89 12 283241 389 50321482
Mitral valve calcification 10.36 9.89 19 283234 942 50320929
Environmental exposure 10.30 9.89 6 283247 70 50321801
Metastases to fallopian tube 10.30 9.89 5 283248 39 50321832
Upper gastrointestinal haemorrhage 10.28 9.89 136 283117 15899 50305972
Galactorrhoea 10.24 9.89 4 283249 3719 50318152
Neurotoxicity 10.23 9.89 45 283208 14695 50307176
Facial bones fracture 10.21 9.89 40 283213 3137 50318734
Mucosal haemorrhage 10.16 9.89 17 283236 783 50321088
Blood iron abnormal 10.14 9.89 3 283250 3323 50318548
International normalised ratio abnormal 10.13 9.89 37 283216 2806 50319065
Incorrect route of product administration 10.13 9.89 62 283191 18604 50303267
Reaction to excipient 10.12 9.89 21 283232 1141 50320730
Mesenteric haemorrhage 10.09 9.89 5 283248 41 50321830
Neonatal anuria 10.09 9.89 5 283248 41 50321830
Multiple-drug resistance 10.08 9.89 3 283250 3311 50318560
Tongue blistering 10.07 9.89 23 283230 1335 50320536
Cerebellar haemorrhage 10.05 9.89 22 283231 1241 50320630
Cerebral ischaemia 10.04 9.89 62 283191 5846 50316025
Eczema eyelids 10.03 9.89 7 283246 114 50321757
Urinary tract infection bacterial 10.02 9.89 48 283205 4111 50317760
Toxic skin eruption 10.01 9.89 31 283222 11220 50310651
Catheterisation cardiac 10 9.89 47 283206 3993 50317878
Subclavian artery stenosis 9.99 9.89 8 283245 162 50321709
Hallucination, visual 9.96 9.89 139 283114 16443 50305428
Unwanted awareness during anaesthesia 9.95 9.89 10 283243 275 50321596
Body mass index abnormal 9.95 9.89 6 283247 75 50321796
Wound infection pseudomonas 9.93 9.89 22 283231 1251 50320620
Paradoxical drug reaction 9.89 9.89 4 283249 3643 50318228

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1229.41 10.91 2811 247350 107485 29216881
Cardiac failure congestive 649.43 10.91 1760 248401 74821 29249545
Coronary artery disease 611.48 10.91 1231 248930 42959 29281407
Bradycardia 482.62 10.91 1433 248728 64196 29260170
Atrial fibrillation 479.28 10.91 1965 248196 103681 29220685
Acute myocardial infarction 342.08 10.91 1043 249118 47395 29276971
Off label use 335.29 10.91 1360 248801 299440 29024926
Coronary artery bypass 317.04 10.91 285 249876 4400 29319966
Drug abuse 308.11 10.91 145 250016 79738 29244628
Dizziness 280.81 10.91 2639 247522 187045 29137321
Hypotension 268.99 10.91 2666 247495 191688 29132678
Syncope 262.27 10.91 1370 248791 80001 29244365
Product prescribing error 229.84 10.91 485 249676 17491 29306875
Drug ineffective 198.17 10.91 2042 248119 361128 28963238
Febrile neutropenia 190.71 10.91 416 249745 111824 29212542
Coronary arterial stent insertion 179.34 10.91 192 249969 3705 29320661
Dyspnoea 177.84 10.91 3806 246355 322926 29001440
Neutropenia 175.80 10.91 551 249610 131160 29193206
Cerebrovascular accident 163.70 10.91 1163 248998 75748 29248618
Angina unstable 142.20 10.91 296 249865 10569 29313797
Pyrexia 135.34 10.91 1671 248490 285951 29038415
Drug reaction with eosinophilia and systemic symptoms 127.52 10.91 39 250122 27953 29296413
Product use in unapproved indication 125.54 10.91 350 249811 86525 29237841
Hepatic function abnormal 122.10 10.91 92 250069 39167 29285199
Angina pectoris 115.80 10.91 505 249656 27345 29297021
Cardiac disorder 113.48 10.91 618 249543 36645 29287721
Fall 107.84 10.91 2100 248061 175078 29149288
Chest pain 101.83 10.91 1418 248743 110555 29213811
Completed suicide 95.90 10.91 1176 248985 89070 29235296
Asthenia 94.37 10.91 2435 247726 212815 29111551
Treatment failure 93.04 10.91 105 250056 36834 29287532
Atrial flutter 88.62 10.91 289 249872 13605 29310761
Interstitial lung disease 86.75 10.91 228 249933 57490 29266876
Vascular graft 83.74 10.91 79 250082 1301 29323065
Ventricular tachycardia 78.12 10.91 388 249773 22186 29302180
General physical health deterioration 76.59 10.91 1259 248902 101598 29222768
Haematochezia 76.14 10.91 555 249606 36428 29287938
Mucosal inflammation 73.02 10.91 96 250065 31499 29292867
Coronary artery occlusion 71.76 10.91 218 249943 9876 29314490
Fatigue 71.61 10.91 3319 246842 313502 29010864
Arrhythmia 71.54 10.91 482 249679 30831 29293535
Neutrophil count decreased 70.22 10.91 166 249995 43401 29280965
Drug resistance 70.21 10.91 48 250113 21492 29302874
Hypertensive emergency 69.04 10.91 57 250104 779 29323587
Acute coronary syndrome 66.08 10.91 242 249919 12083 29312283
Eosinophilia 65.05 10.91 55 250106 22106 29302260
International normalised ratio increased 64.64 10.91 616 249545 43756 29280610
Therapeutic product effect incomplete 62.36 10.91 151 250010 39154 29285212
Septic shock 61.90 10.91 295 249866 62265 29262101
Asthma 60.30 10.91 122 250039 33727 29290639
Infusion related reaction 60.28 10.91 181 249980 43705 29280661
Hepatocellular injury 57.27 10.91 57 250104 21186 29303180
Gastrointestinal haemorrhage 57.14 10.91 968 249193 78565 29245801
Suicidal ideation 56.96 10.91 131 250030 34585 29289781
Bone marrow failure 56.93 10.91 90 250071 27359 29297007
Lower respiratory tract infection 54.86 10.91 87 250074 26415 29297951
Thrombocytopenia 54.21 10.91 808 249353 134015 29190351
Sinus bradycardia 53.35 10.91 217 249944 11386 29312980
Pneumocystis jirovecii pneumonia 52.57 10.91 39 250122 16740 29307626
Myocardial ischaemia 52.30 10.91 271 249890 15757 29308609
Product monitoring error 52.18 10.91 86 250075 2559 29321807
Sopor 52.07 10.91 14 250147 10920 29313446
Drug dependence 51.35 10.91 61 250100 20920 29303446
Cytomegalovirus infection 51.16 10.91 73 250088 23142 29301224
Immune reconstitution inflammatory syndrome 50.79 10.91 4 250157 7798 29316568
Product use issue 50.64 10.91 243 249918 51201 29273165
Seizure 49.84 10.91 525 249636 92598 29231768
Bronchopulmonary aspergillosis 49.75 10.91 21 250140 12323 29312043
Rash maculo-papular 49.09 10.91 81 250080 24208 29300158
Pathogen resistance 48.04 10.91 6 250155 8110 29316256
Hepatic cytolysis 47.43 10.91 7 250154 8340 29316026
Toxic skin eruption 47.40 10.91 12 250149 9745 29314621
Coronary artery stenosis 46.52 10.91 169 249992 8404 29315962
Agitation 45.61 10.91 251 249910 51053 29273313
Dehydration 45.52 10.91 1282 248879 113466 29210900
Aggression 44.33 10.91 153 250008 35388 29288978
Palpitations 43.75 10.91 445 249716 32159 29292207
Cardiac arrest 43.31 10.91 988 249173 84603 29239763
Injury 42.79 10.91 292 249869 18754 29305612
Toxic epidermal necrolysis 42.10 10.91 55 250106 18098 29306268
Haematotoxicity 42.07 10.91 4 250157 6695 29317671
Device interaction 42.03 10.91 36 250125 519 29323847
Lymphopenia 41.70 10.91 32 250129 13501 29310865
Liver disorder 41.38 10.91 110 250051 27639 29296727
Rheumatoid arthritis 41.06 10.91 137 250024 32015 29292351
Renal injury 40.13 10.91 182 249979 10020 29314346
Suspected suicide 39.74 10.91 98 250063 3922 29320444
Transient ischaemic attack 39.49 10.91 334 249827 22936 29301430
Respiratory depression 39.15 10.91 34 250127 13489 29310877
Nodal arrhythmia 38.86 10.91 40 250121 736 29323630
Synovitis 38.62 10.91 22 250139 10868 29313498
Irritability 38.47 10.91 81 250080 22071 29302295
Disseminated intravascular coagulation 38.21 10.91 69 250092 19911 29304455
Intentional product use issue 37.72 10.91 208 249953 42290 29282076
Anhedonia 37.45 10.91 140 250021 7060 29317306
Wound 36.65 10.91 200 249961 11863 29312503
Malignant neoplasm progression 36.48 10.91 424 249737 73435 29250931
Fear 36.23 10.91 168 249993 9336 29315030
Oedema peripheral 36.19 10.91 1139 249022 102418 29221948
Haemophagocytic lymphohistiocytosis 36.15 10.91 22 250139 10482 29313884
Pancytopenia 36.01 10.91 491 249670 82677 29241689
Infective pulmonary exacerbation of cystic fibrosis 35.97 10.91 5 250156 6231 29318135
Substance abuse 35.68 10.91 7 250154 6780 29317586
Atrioventricular block 35.68 10.91 135 250026 6847 29317519
Agranulocytosis 35.63 10.91 74 250087 20266 29304100
Ejection fraction decreased 35.32 10.91 244 249917 15734 29308632
Aspergillus infection 35.26 10.91 23 250138 10558 29313808
Drug hypersensitivity 35.23 10.91 389 249772 68017 29256349
Myelosuppression 35.08 10.91 31 250130 12196 29312170
Hyperthermia 34.98 10.91 18 250143 9412 29314954
Atrioventricular block complete 34.62 10.91 147 250014 7864 29316502
Haemorrhage intracranial 34.50 10.91 226 249935 14316 29310050
Cholestasis 34.24 10.91 94 250067 23368 29300998
C-reactive protein increased 33.36 10.91 228 249933 44035 29280331
Acute generalised exanthematous pustulosis 33.35 10.91 4 250157 5579 29318787
Progressive multifocal leukoencephalopathy 33.31 10.91 16 250145 8703 29315663
Rhabdomyolysis 33.30 10.91 710 249451 60098 29264268
Unevaluable event 32.96 10.91 392 249769 29459 29294907
Acute graft versus host disease 32.83 10.91 5 250156 5819 29318547
Acute lung injury 32.81 10.91 48 250113 1285 29323081
Abnormal behaviour 32.75 10.91 94 250067 23033 29301333
Drug eruption 32.75 10.91 57 250104 16684 29307682
Overdose 32.51 10.91 477 249684 79342 29245024
Coma 32.38 10.91 198 249963 39252 29285114
Anaphylactic reaction 32.20 10.91 122 250039 27451 29296915
Sinus node dysfunction 31.74 10.91 86 250075 3648 29320718
Urticaria 31.36 10.91 303 249858 54357 29270009
Labelled drug-drug interaction medication error 31.35 10.91 193 249968 11966 29312400
Haematoma 30.75 10.91 316 249845 22896 29301470
C-reactive protein abnormal 29.95 10.91 9 250152 6527 29317839
Respiratory distress 29.68 10.91 155 250006 31951 29292415
Therapeutic drug monitoring analysis not performed 29.64 10.91 28 250133 462 29323904
Blood loss anaemia 29.61 10.91 131 250030 7135 29317231
Altered state of consciousness 29.53 10.91 79 250082 19810 29304556
Dyspnoea exertional 29.50 10.91 453 249708 36037 29288329
Neuroleptic malignant syndrome 28.92 10.91 58 250103 16090 29308276
Ascites 28.92 10.91 186 249975 36433 29287933
Mitral valve incompetence 28.80 10.91 202 249959 13091 29311275
Cardiac failure chronic 28.20 10.91 119 250042 6348 29318018
Suicide attempt 28.10 10.91 171 249990 33939 29290427
Obstructive airways disorder 28.07 10.91 31 250130 10985 29313381
Myxoedema coma 27.88 10.91 21 250140 249 29324117
Alanine aminotransferase increased 27.84 10.91 427 249734 70517 29253849
Pacemaker generated rhythm 27.75 10.91 13 250148 57 29324309
BRASH syndrome 27.67 10.91 17 250144 140 29324226
Aortic stenosis 27.58 10.91 84 250077 3810 29320556
Venoocclusive liver disease 27.50 10.91 12 250149 6905 29317461
Anaphylactic shock 27.39 10.91 44 250117 13292 29311074
Heart rate increased 27.24 10.91 472 249689 38466 29285900
Catatonia 27.20 10.91 3 250158 4465 29319901
Sinus arrest 27.14 10.91 46 250115 1401 29322965
Graft versus host disease 26.92 10.91 25 250136 9603 29314763
Atrial thrombosis 26.90 10.91 55 250106 1938 29322428
Presyncope 26.80 10.91 230 249931 15859 29308507
Orthostatic hypotension 26.69 10.91 301 249860 22328 29302038
Heart rate decreased 26.57 10.91 325 249836 24587 29299779
Chronotropic incompetence 26.51 10.91 9 250152 12 29324354
Multiple organ dysfunction syndrome 26.46 10.91 375 249786 62741 29261625
Mitral valve disease 26.14 10.91 41 250120 1169 29323197
Stomatitis 26.10 10.91 195 249966 36918 29287448
Foetal exposure during pregnancy 25.74 10.91 174 249987 33693 29290673
Colitis 25.56 10.91 157 250004 31091 29293275
Malaise 25.48 10.91 1097 249064 158505 29165861
Abdominal pain lower 25.43 10.91 142 250019 8496 29315870
Erythema multiforme 25.41 10.91 17 250144 7700 29316666
Shone complex 25.35 10.91 13 250148 72 29324294
Arteriosclerosis 25.32 10.91 161 250000 10095 29314271
Extrapyramidal disorder 24.93 10.91 33 250128 10798 29313568
Cardiac operation 24.74 10.91 63 250098 2573 29321793
Psychomotor hyperactivity 24.57 10.91 20 250141 8193 29316173
Exposure during pregnancy 24.17 10.91 22 250139 8532 29315834
Epstein-Barr virus infection 24.07 10.91 13 250148 6616 29317750
Peripheral vascular disorder 23.91 10.91 89 250072 4478 29319888
Chronic graft versus host disease 23.79 10.91 3 250158 4026 29320340
Sedation 23.73 10.91 72 250089 17333 29307033
Blood creatinine increased 23.46 10.91 911 249250 84191 29240175
Coagulopathy 23.35 10.91 243 249918 17664 29306702
Hyponatraemia 23.28 10.91 417 249744 67216 29257150
Hyperbilirubinaemia 23.18 10.91 58 250103 14876 29309490
Renal failure 22.99 10.91 1225 248936 117374 29206992
Multiple-drug resistance 22.80 10.91 3 250158 3897 29320469
Status epilepticus 22.75 10.91 35 250126 10759 29313607
Cardiac valve disease 22.63 10.91 64 250097 2784 29321582
Hypertriglyceridaemia 22.62 10.91 18 250143 7457 29316909
Blood glucose increased 22.53 10.91 656 249505 58328 29266038
Carcinoma in situ of skin 22.50 10.91 12 250149 73 29324293
Pancreatitis acute 22.38 10.91 118 250043 24267 29300099
Fracture 22.34 10.91 106 250055 5947 29318419
Headache 22.09 10.91 1225 248936 172782 29151584
Hyperlipidaemia 22.04 10.91 182 249979 12408 29311958
Troponin increased 21.96 10.91 143 250018 9040 29315326
Supraventricular tachycardia 21.88 10.91 151 250010 9733 29314633
Erythema 21.85 10.91 480 249681 75126 29249240
Toxicity to various agents 21.78 10.91 1224 248937 172437 29151929
Exercise tolerance decreased 21.78 10.91 82 250079 4149 29320217
Leukopenia 21.74 10.91 332 249829 54871 29269495
Aorta hypoplasia 21.73 10.91 12 250149 79 29324287
Pericardial haemorrhage 21.49 10.91 64 250097 2867 29321499
Blood pressure inadequately controlled 21.34 10.91 56 250105 2330 29322036
Aspartate aminotransferase increased 21.27 10.91 366 249795 59359 29265007
Contusion 21.06 10.91 375 249786 30720 29293646
Arteriosclerosis coronary artery 20.59 10.91 157 250004 10448 29313918
Circulatory collapse 20.52 10.91 245 249916 18428 29305938
Pneumonia aspiration 20.50 10.91 205 249956 36532 29287834
Infection 20.29 10.91 494 249667 76257 29248109
Hypoalbuminaemia 20.24 10.91 35 250126 10270 29314096
Epilepsy 19.97 10.91 84 250077 18348 29306018
Sinusitis 19.87 10.91 190 249971 34160 29290206
Hypertensive crisis 19.87 10.91 124 250037 7724 29316642
Neuropathy vitamin B12 deficiency 19.86 10.91 8 250153 22 29324344
Low density lipoprotein abnormal 19.85 10.91 17 250144 245 29324121
Mental status changes 19.82 10.91 410 249751 34517 29289849
Rash 19.78 10.91 1361 248800 188458 29135908
Intracardiac thrombus 19.65 10.91 53 250108 2242 29322124
Hepatitis B 19.64 10.91 11 250150 5486 29318880
Ventricular extrasystoles 19.63 10.91 155 250006 10427 29313939
Mouth ulceration 19.59 10.91 36 250125 10319 29314047
Hyperkalaemia 19.30 10.91 667 249494 60725 29263641
Immune thrombocytopenia 19.17 10.91 23 250138 7854 29316512
Nephrogenic systemic fibrosis 19.14 10.91 75 250086 3867 29320499
Ventricular hypokinesia 19.13 10.91 83 250078 4482 29319884
Internal haemorrhage 18.95 10.91 81 250080 4346 29320020
Postural orthostatic tachycardia syndrome 18.94 10.91 9 250152 41 29324325
Autoimmune myositis 18.91 10.91 11 250150 81 29324285
Hepatocellular carcinoma 18.84 10.91 19 250142 7019 29317347
Emotional distress 18.80 10.91 190 249971 13705 29310661
Sepsis 18.74 10.91 1001 249160 141681 29182685
Drug intolerance 18.70 10.91 292 249869 48087 29276279
Acute graft versus host disease in skin 18.69 10.91 8 250153 4656 29319710
Upper motor neurone lesion 18.66 10.91 12 250149 108 29324258
Basal ganglia haemorrhage 18.64 10.91 28 250133 768 29323598
Uveitis 18.40 10.91 14 250147 5933 29318433
Osteonecrosis 18.38 10.91 56 250105 13463 29310903
Face oedema 18.36 10.91 37 250124 10246 29314120
Chronic kidney disease 18.28 10.91 420 249741 35996 29288370
Blood pressure abnormal 18.28 10.91 109 250052 6681 29317685
Drug withdrawal syndrome 18.25 10.91 84 250077 17900 29306466
Bundle branch block right 18.19 10.91 108 250053 6609 29317757
Vomiting 18.17 10.91 1547 248614 210713 29113653
Supravalvular aortic stenosis 18.13 10.91 9 250152 46 29324320
Obsessive-compulsive disorder 18.10 10.91 8 250153 4568 29319798
Fluid retention 18.09 10.91 290 249871 23270 29301096
Cytokine release syndrome 18.08 10.91 54 250107 13065 29311301
Oesophageal obstruction 18.08 10.91 20 250141 401 29323965
Heart rate irregular 18.06 10.91 180 249981 12937 29311429
Drug abuser 18.03 10.91 5 250156 3822 29320544
Diffuse large B-cell lymphoma 17.90 10.91 16 250145 6260 29318106
Tumour lysis syndrome 17.83 10.91 59 250102 13825 29310541
Heart rate abnormal 17.83 10.91 41 250120 1568 29322798
Stent placement 17.82 10.91 78 250083 4228 29320138
Gout 17.76 10.91 220 249941 16691 29307675
Therapy partial responder 17.74 10.91 11 250150 5188 29319178
Hepatitis B reactivation 17.69 10.91 3 250158 3226 29321140
Tuberculosis 17.52 10.91 21 250140 7175 29317191
Non-cardiac chest pain 17.40 10.91 73 250088 3884 29320482
Medication error 17.40 10.91 264 249897 20947 29303419
Dysgeusia 17.38 10.91 279 249882 22395 29301971
Tenosynovitis 17.36 10.91 5 250156 3728 29320638
Cardiovascular disorder 17.19 10.91 132 250029 8803 29315563
Cytopenia 17.16 10.91 36 250125 9823 29314543
Akathisia 17.15 10.91 19 250142 6723 29317643
Nodular rash 17.10 10.91 11 250150 99 29324267
Neutropenic sepsis 17.09 10.91 47 250114 11680 29312686
Cornea verticillata 17.09 10.91 8 250153 35 29324331
Appendicitis 17.07 10.91 30 250131 8749 29315617
Macrophages increased 16.73 10.91 13 250148 162 29324204
Atrioventricular block first degree 16.71 10.91 89 250072 5230 29319136
Drug-disease interaction 16.70 10.91 18 250143 350 29324016
Occult blood positive 16.61 10.91 69 250092 3655 29320711
Mitral valve hypoplasia 16.58 10.91 8 250153 38 29324328
Orthostatic intolerance 16.53 10.91 24 250137 638 29323728
Blood pressure increased 16.50 10.91 773 249388 73030 29251336
Large for dates baby 16.38 10.91 28 250133 859 29323507
Pulmonary tuberculosis 16.36 10.91 8 250153 4307 29320059
Coronary angioplasty 16.30 10.91 18 250143 360 29324006
Diabetic foetopathy 16.22 10.91 14 250147 204 29324162
Bacterial parotitis 16.20 10.91 6 250155 12 29324354
Lower gastrointestinal haemorrhage 16.18 10.91 122 250039 8091 29316275
Aplastic anaemia 16.17 10.91 24 250137 7486 29316880
Nodal rhythm 16.16 10.91 35 250126 1285 29323081
Gastrointestinal tract mucosal pigmentation 16.11 10.91 18 250143 365 29324001
Peripheral arterial occlusive disease 15.99 10.91 85 250076 4991 29319375
Arthralgia 15.89 10.91 993 249168 138624 29185742
Psoriatic arthropathy 15.89 10.91 67 250094 14624 29309742
Leukoencephalopathy 15.85 10.91 6 250155 3761 29320605
Blood glucose decreased 15.84 10.91 164 249997 11905 29312461
Ventricular fibrillation 15.79 10.91 204 249957 15629 29308737
Somnolence 15.77 10.91 642 249519 93313 29231053
Dysmorphism 15.76 10.91 3 250158 2968 29321398
Thrombotic microangiopathy 15.70 10.91 31 250130 8650 29315716
Cytomegalovirus chorioretinitis 15.70 10.91 4 250157 3234 29321132
Dizziness postural 15.65 10.91 88 250073 5279 29319087
Pruritus genital 15.60 10.91 21 250140 519 29323847
Full blood count decreased 15.51 10.91 205 249956 15787 29308579
Blood urine present 15.49 10.91 138 250023 9617 29314749
Product residue present 15.46 10.91 52 250109 2487 29321879
Neuropathy peripheral 15.43 10.91 470 249691 70557 29253809
Cardiac failure 15.36 10.91 819 249342 78468 29245898
Therapeutic product effect decreased 15.34 10.91 167 249994 29284 29295082
Plasma cell myeloma 15.34 10.91 417 249744 36698 29287668
Intentional self-injury 15.29 10.91 54 250107 12407 29311959
Nocturia 15.24 10.91 122 250039 8240 29316126
Hepatitis 15.19 10.91 108 250053 20675 29303691
Haemoglobin decreased 15.15 10.91 1088 249073 107287 29217079
Electrocardiogram RR interval prolonged 15.12 10.91 4 250157 0 29324366
Cerebral haemorrhage 15.02 10.91 360 249801 31066 29293300
Alcohol abuse 15.02 10.91 9 250152 4324 29320042
Drug withdrawal syndrome neonatal 14.98 10.91 5 250156 3390 29320976
Cardiovascular insufficiency 14.89 10.91 35 250126 1358 29323008
Graft versus host disease in skin 14.87 10.91 5 250156 3374 29320992
Dyskinesia 14.78 10.91 104 250057 19957 29304409
Pallor 14.75 10.91 255 249906 20769 29303597
Exposure via ingestion 14.73 10.91 44 250117 1974 29322392
Essential hypertension 14.73 10.91 50 250111 2403 29321963
Pulmonary renal syndrome 14.65 10.91 12 250149 162 29324204
Joint swelling 14.64 10.91 314 249847 49316 29275050
Hypogammaglobulinaemia 14.64 10.91 17 250144 5890 29318476
Asphyxia 14.63 10.91 14 250147 5301 29319065
Post procedural haemorrhage 14.60 10.91 111 250050 7380 29316986
Migraine 14.51 10.91 55 250106 12375 29311991
Blood pressure orthostatic 14.45 10.91 8 250153 53 29324313
Hepatojugular reflux 14.44 10.91 19 250142 459 29323907
Extrasystoles 14.43 10.91 63 250098 3411 29320955
Hyperferritinaemia 14.41 10.91 16 250145 322 29324044
Haemodilution 14.38 10.91 7 250154 34 29324332
Lung disorder 14.33 10.91 176 249985 30186 29294180
Antiacetylcholine receptor antibody positive 14.32 10.91 8 250153 54 29324312
Congenital heart valve disorder 14.32 10.91 8 250153 54 29324312
Blood potassium increased 14.28 10.91 188 249973 14463 29309903
Muscle necrosis 14.24 10.91 25 250136 784 29323582
Cystitis haemorrhagic 14.23 10.91 12 250149 4830 29319536
Left atrial enlargement 14.21 10.91 24 250137 729 29323637
Platelet count decreased 14.18 10.91 732 249429 103940 29220426
Gamma-glutamyltransferase increased 14.17 10.91 151 250010 26586 29297780
Penis injury 14.16 10.91 14 250147 245 29324121
Miosis 14.14 10.91 29 250132 7980 29316386
Euphoric mood 14.13 10.91 12 250149 4813 29319553
Neonatal respiratory failure 14.07 10.91 16 250145 331 29324035
Disease recurrence 14.05 10.91 78 250083 15836 29308530
Chest discomfort 14.05 10.91 498 249663 45485 29278881
Nocardiosis 14.04 10.91 5 250156 3255 29321111
Graft versus host disease in gastrointestinal tract 14.03 10.91 5 250156 3253 29321113
Autoimmune myocarditis 14.01 10.91 12 250149 173 29324193
Tricuspid valve incompetence 13.98 10.91 120 250041 8274 29316092
Biopsy lymph gland 13.97 10.91 8 250153 57 29324309
Intracranial pressure increased 13.93 10.91 6 250155 3479 29320887
Withdrawal syndrome 13.92 10.91 47 250114 10945 29313421
Condition aggravated 13.92 10.91 1057 249104 145238 29179128
Lymphoma 13.87 10.91 40 250121 9788 29314578
Urinary tract obstruction 13.86 10.91 60 250101 3237 29321129
Penile haemorrhage 13.79 10.91 21 250140 583 29323783
Electrocardiogram QRS complex prolonged 13.76 10.91 70 250091 4040 29320326
Anti-neutrophil cytoplasmic antibody positive vasculitis 13.75 10.91 23 250138 693 29323673
Generalised tonic-clonic seizure 13.72 10.91 100 250061 19039 29305327
Spinal epidural haemorrhage 13.62 10.91 7 250154 39 29324327
Cardiac pacemaker insertion 13.56 10.91 49 250112 2430 29321936
End stage renal disease 13.53 10.91 111 250050 7553 29316813
White blood cell count decreased 13.48 10.91 572 249589 82790 29241576
Oral candidiasis 13.47 10.91 46 250115 10676 29313690
Disease progression 13.47 10.91 561 249600 81355 29243011
Affect lability 13.37 10.91 6 250155 3396 29320970
Portal fibrosis 13.35 10.91 15 250146 306 29324060
Priapism 13.34 10.91 11 250150 4477 29319889
Pseudomonas infection 13.34 10.91 47 250114 10805 29313561
Herpes simplex 13.32 10.91 13 250148 4877 29319489
Aplasia 13.31 10.91 9 250152 4054 29320312
Bronchiectasis 13.27 10.91 22 250139 6563 29317803
Diverticulum intestinal haemorrhagic 13.24 10.91 43 250118 2019 29322347
Precancerous skin lesion 13.22 10.91 20 250141 552 29323814
Central nervous system lesion 13.21 10.91 17 250144 5631 29318735
Inspiratory capacity abnormal 13.21 10.91 9 250152 90 29324276
Aortic valve incompetence 13.19 10.91 80 250081 4933 29319433
Kidney rupture 13.15 10.91 12 250149 189 29324177
High density lipoprotein decreased 13.13 10.91 55 250106 2924 29321442
Iliac artery stenosis 13.11 10.91 8 250153 65 29324301
Ventricular arrhythmia 13.10 10.91 75 250086 4529 29319837
Device related infection 13.08 10.91 78 250083 15558 29308808
Posterior reversible encephalopathy syndrome 13.06 10.91 36 250125 8940 29315426
Jaundice 13.01 10.91 172 249989 29124 29295242
Diverticulum 13.01 10.91 95 250066 6237 29318129
Loss of personal independence in daily activities 12.96 10.91 145 250016 25295 29299071
Secretion discharge 12.91 10.91 10 250151 4200 29320166
Glomerular filtration rate decreased 12.90 10.91 149 250012 11117 29313249
Increased tendency to bruise 12.87 10.91 62 250099 3500 29320866
Idiopathic pulmonary fibrosis 12.82 10.91 57 250104 3111 29321255
Increased viscosity of bronchial secretion 12.80 10.91 12 250149 196 29324170
Systemic infection 12.77 10.91 43 250118 2058 29322308
No adverse event 12.69 10.91 91 250070 17387 29306979
Apallic syndrome 12.68 10.91 13 250148 238 29324128
Facial asymmetry 12.64 10.91 14 250147 281 29324085
Acoustic stimulation tests abnormal 12.62 10.91 8 250153 70 29324296
Heart valve incompetence 12.61 10.91 30 250131 1173 29323193
Neonatal tachycardia 12.61 10.91 5 250156 13 29324353
Torsade de pointes 12.59 10.91 98 250063 6563 29317803
Pulmonary valve stenosis congenital 12.58 10.91 10 250151 129 29324237
Venoocclusive disease 12.57 10.91 3 250158 2536 29321830
Arteriosclerotic gangrene 12.53 10.91 8 250153 71 29324295
Blood alkaline phosphatase abnormal 12.50 10.91 16 250145 376 29323990
Cardiogenic shock 12.49 10.91 230 249931 18960 29305406
Ageusia 12.47 10.91 123 250038 8815 29315551
Dermatitis exfoliative 12.45 10.91 22 250139 6403 29317963
Chromaturia 12.37 10.91 164 249997 12638 29311728
Dermatitis acneiform 12.36 10.91 17 250144 5474 29318892
Parathyroid hormone-related protein abnormal 12.35 10.91 5 250156 14 29324352
Coma scale abnormal 12.31 10.91 7 250154 3462 29320904
Parkinsonism 12.31 10.91 27 250134 7251 29317115
Folliculitis 12.30 10.91 9 250152 3891 29320475
Low cardiac output syndrome 12.27 10.91 18 250143 483 29323883
Blue toe syndrome 12.21 10.91 10 250151 135 29324231
Cardiac function test abnormal 12.19 10.91 6 250155 30 29324336
Neurotoxicity 12.17 10.91 73 250088 14540 29309826
Vascular stent thrombosis 12.15 10.91 49 250112 2561 29321805
Orthopnoea 12.14 10.91 73 250088 4487 29319879
Vasoplegia syndrome 12.09 10.91 34 250127 1474 29322892
Eczema 12.08 10.91 68 250093 13758 29310608
Aortic aneurysm 12.03 10.91 92 250069 6128 29318238
Upper gastrointestinal haemorrhage 12.03 10.91 256 249905 21658 29302708
Pulse pressure decreased 12.02 10.91 11 250150 174 29324192
Product solubility abnormal 11.99 10.91 17 250144 442 29323924
Implantable defibrillator insertion 11.97 10.91 21 250140 658 29323708
Paronychia 11.94 10.91 5 250156 2948 29321418
Stevens-Johnson syndrome 11.92 10.91 86 250075 16411 29307955
Aortic valve sclerosis 11.91 10.91 23 250138 777 29323589
Alcohol interaction 11.89 10.91 4 250157 2699 29321667
Lymphomatoid papulosis 11.87 10.91 11 250150 177 29324189
Mitral valve prolapse 11.83 10.91 19 250142 553 29323813
Hyperthyroidism 11.79 10.91 118 250043 8490 29315876
Carcinoid tumour of the gastrointestinal tract 11.77 10.91 7 250154 54 29324312
Blood cholinesterase decreased 11.72 10.91 9 250152 110 29324256
Balance disorder 11.62 10.91 394 249767 35776 29288590
Thoracic haemorrhage 11.62 10.91 11 250150 182 29324184
Musculoskeletal pain 11.60 10.91 324 249837 28629 29295737
Encephalitis 11.60 10.91 23 250138 6407 29317959
Lymphadenopathy 11.52 10.91 146 250015 24903 29299463
Bradyarrhythmia 11.51 10.91 40 250121 1945 29322421
Dystonia 11.47 10.91 43 250118 9706 29314660
Cardiovascular somatic symptom disorder 11.45 10.91 6 250155 35 29324331
Hepatic encephalopathy 11.45 10.91 64 250097 12971 29311395
Post transplant lymphoproliferative disorder 11.40 10.91 18 250143 5475 29318891
Acute lymphocytic leukaemia 11.39 10.91 4 250157 2627 29321739
Oxygen saturation decreased 11.39 10.91 291 249870 44646 29279720
Pulmonary fibrosis 11.37 10.91 81 250080 15501 29308865
Therapeutic response decreased 11.37 10.91 144 250017 24567 29299799
Venous pressure jugular abnormal 11.34 10.91 3 250158 0 29324366
Paraganglion neoplasm 11.34 10.91 3 250158 0 29324366
Myofascial spasm 11.34 10.91 3 250158 0 29324366
Non-small cell lung cancer stage IIIA 11.34 10.91 3 250158 0 29324366
Blood bilirubin increased 11.33 10.91 210 249951 33683 29290683
Hepatosplenomegaly 11.18 10.91 9 250152 3708 29320658
Injection site pain 11.17 10.91 200 249961 32246 29292120
Atrial tachycardia 11.16 10.91 39 250122 1902 29322464
Cardioversion 11.14 10.91 23 250138 816 29323550
Anal abscess 11.09 10.91 17 250144 5234 29319132
Pyonephrosis 11.07 10.91 7 250154 61 29324305
Sprue-like enteropathy 11.06 10.91 16 250145 424 29323942
Organising pneumonia 11.00 10.91 16 250145 5032 29319334
Histology abnormal 10.95 10.91 13 250148 282 29324084
Mucosal haemorrhage 10.95 10.91 33 250128 1488 29322878
Pharyngitis 10.93 10.91 27 250134 6956 29317410
Haemorrhage 10.92 10.91 476 249685 44596 29279770

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2432.25 10.03 4141 427525 161680 63905386
Cardiac failure congestive 1390.28 10.03 2844 428822 127736 63939330
Coronary artery disease 1199.51 10.03 1736 429930 58697 64008369
Bradycardia 1012.14 10.03 2359 429307 115860 63951206
Atrial fibrillation 1007.78 10.03 2968 428698 168121 63898945
Acute myocardial infarction 782.42 10.03 1553 430113 68165 63998901
Drug ineffective 559.56 10.03 3321 428345 836926 63230140
Hypotension 549.51 10.03 4391 427275 376583 63690483
Off label use 531.66 10.03 2306 429360 630500 63436566
Product prescribing error 507.95 10.03 875 430791 34394 64032672
Coronary artery bypass 491.08 10.03 365 431301 5450 64061616
Synovitis 489.57 10.03 48 431618 99042 63968024
Syncope 488.94 10.03 2221 429445 155414 63911652
Cerebrovascular accident 466.50 10.03 1991 429675 135592 63931474
Completed suicide 463.06 10.03 2824 428842 221590 63845476
Dizziness 397.84 10.03 4513 427153 425650 63641416
Hand deformity 333.40 10.03 22 431644 62749 64004317
Drug intolerance 325.10 10.03 471 431195 187521 63879545
Infusion related reaction 323.61 10.03 374 431292 164093 63902973
Pemphigus 300.86 10.03 29 431637 60672 64006394
Coronary arterial stent insertion 298.87 10.03 271 431395 5421 64061645
Joint swelling 295.79 10.03 624 431042 214758 63852308
Systemic lupus erythematosus 295.67 10.03 77 431589 77535 63989531
Drug abuse 282.69 10.03 281 431385 132093 63934973
Treatment failure 280.69 10.03 222 431444 116594 63950472
Dyspnoea 280.44 10.03 6532 425134 712142 63354924
Angina unstable 270.46 10.03 419 431247 15048 64052018
Lower respiratory tract infection 270.36 10.03 148 431518 94466 63972600
Arthropathy 258.05 10.03 257 431409 120710 63946356
Rheumatoid arthritis 257.99 10.03 439 431227 163855 63903211
General physical health deterioration 241.38 10.03 2256 429410 202169 63864897
Fall 238.34 10.03 4015 427651 412811 63654255
Angina pectoris 235.81 10.03 751 430915 44330 64022736
Gastrointestinal haemorrhage 227.93 10.03 1592 430074 130720 63936346
Cardiac disorder 227.62 10.03 856 430810 54960 64012106
Haematochezia 219.72 10.03 954 430712 65419 64001647
Therapeutic product effect decreased 218.64 10.03 270 431396 115081 63951985
Rheumatoid factor positive 213.62 10.03 4 431662 34934 64032132
Glossodynia 211.38 10.03 84 431582 64612 64002454
Contraindicated product administered 210.10 10.03 247 431419 107582 63959484
Pericarditis 204.53 10.03 81 431585 62435 64004631
Febrile neutropenia 198.73 10.03 620 431046 187037 63880029
Hypersensitivity 194.94 10.03 668 430998 195784 63871282
Pyrexia 191.85 10.03 2611 429055 556033 63511033
Neutropenia 190.82 10.03 889 430777 238735 63828331
Duodenal ulcer perforation 187.26 10.03 11 431655 34614 64032452
Product monitoring error 185.29 10.03 205 431461 5249 64061817
Helicobacter infection 175.93 10.03 24 431642 38338 64028728
Ventricular tachycardia 173.91 10.03 565 431101 33700 64033366
International normalised ratio increased 172.34 10.03 1011 430655 78156 63988910
Sinus bradycardia 172.23 10.03 435 431231 22458 64044608
Asthenia 171.32 10.03 3907 427759 424137 63642929
Chest pain 168.36 10.03 2361 429305 233619 63833447
Rash 159.13 10.03 2138 429528 456411 63610655
Drug hypersensitivity 158.67 10.03 937 430729 236878 63830188
Product use in unapproved indication 155.95 10.03 630 431036 175988 63891078
Arthralgia 155.65 10.03 2056 429610 440204 63626862
Maternal exposure during pregnancy 150.63 10.03 256 431410 95628 63971438
Arrhythmia 149.98 10.03 727 430939 52217 64014849
Drug reaction with eosinophilia and systemic symptoms 148.86 10.03 89 431577 54128 64012938
Cardiac arrest 147.53 10.03 1629 430037 152435 63914631
Folliculitis 142.32 10.03 17 431649 30060 64037006
Dehydration 137.39 10.03 2125 429541 214638 63852428
Product use issue 135.29 10.03 539 431127 151176 63915890
Swelling 133.09 10.03 585 431081 159633 63907433
Sinusitis 131.67 10.03 516 431150 145412 63921654
Muscle injury 130.02 10.03 13 431653 26424 64040642
Palpitations 128.14 10.03 1163 430503 103325 63963741
Cardiogenic shock 126.17 10.03 490 431176 31937 64035129
Hepatic enzyme increased 124.04 10.03 449 431217 129494 63937572
C-reactive protein abnormal 122.34 10.03 23 431643 29024 64038042
Renal failure 121.23 10.03 1797 429869 179891 63887175
Atrial flutter 119.35 10.03 342 431324 19038 64048028
Hepatic function abnormal 119.26 10.03 153 431513 64160 64002906
Suspected suicide 118.44 10.03 210 431456 8444 64058622
Alopecia 116.83 10.03 641 431025 165049 63902017
Vascular graft 116.71 10.03 98 431568 1761 64065305
Hypertensive emergency 112.95 10.03 105 431561 2171 64064895
Oedema peripheral 112.31 10.03 2005 429661 208312 63858754
Irritable bowel syndrome 110.34 10.03 56 431610 37313 64029753
Interstitial lung disease 108.33 10.03 316 431350 97416 63969650
Sleep disorder due to general medical condition, insomnia type 108.12 10.03 22 431644 26248 64040818
Myocardial ischaemia 107.88 10.03 372 431294 22879 64044187
Acute coronary syndrome 107.71 10.03 329 431337 18981 64048085
Labelled drug-drug interaction medication error 104.13 10.03 355 431311 21707 64045359
Blood loss anaemia 101.41 10.03 261 431405 13631 64053435
Coronary artery occlusion 96.31 10.03 256 431410 13635 64053431
Drug resistance 95.83 10.03 58 431608 35044 64032022
Infection 94.92 10.03 786 430880 184094 63882972
Death 93.72 10.03 4036 427630 478669 63588397
Mucosal inflammation 90.32 10.03 176 431490 62408 64004658
Musculoskeletal stiffness 88.84 10.03 473 431193 122733 63944333
C-reactive protein increased 88.55 10.03 331 431335 94578 63972488
Discomfort 88.54 10.03 263 431403 80615 63986451
Exposure during pregnancy 88.39 10.03 248 431418 77427 63989639
Sopor 88.25 10.03 44 431622 29617 64037449
Cardiac failure 88.15 10.03 1309 430357 131064 63936002
Pregnancy 86.86 10.03 17 431649 20848 64046218
Pain 85.39 10.03 2941 428725 550570 63516496
Bone marrow failure 83.91 10.03 119 431547 47833 64019233
Drug interaction 82.63 10.03 3081 428585 359002 63708064
Neutrophil count decreased 82.38 10.03 254 431412 76942 63990124
Medication error 82.33 10.03 595 431071 49371 64017695
Rhabdomyolysis 81.48 10.03 956 430710 90770 63976296
Red blood cell sedimentation rate abnormal 80.24 10.03 8 431658 16298 64050768
Blood creatinine increased 79.87 10.03 1315 430351 134467 63932599
Renal injury 79.72 10.03 256 431410 15173 64051893
Nasopharyngitis 79.24 10.03 884 430782 195189 63871877
Hepatocellular injury 78.42 10.03 113 431553 45122 64021944
Therapeutic drug monitoring analysis not performed 78.39 10.03 65 431601 1147 64065919
Blister 77.75 10.03 279 431387 80688 63986378
Erythema 77.35 10.03 839 430827 186231 63880835
Atrioventricular block 76.88 10.03 215 431451 11800 64055266
Suicidal ideation 76.79 10.03 211 431455 66331 64000735
Abortion spontaneous 76.78 10.03 36 431630 25107 64041959
Atrioventricular block complete 76.11 10.03 241 431425 14177 64052889
BRASH syndrome 75.84 10.03 41 431625 336 64066730
Coronary artery stenosis 74.67 10.03 204 431462 11044 64056022
Hypertensive crisis 72.83 10.03 278 431388 17970 64049096
Anti-neutrophil cytoplasmic antibody positive vasculitis 72.79 10.03 94 431572 2842 64064224
Headache 71.39 10.03 2859 428807 526608 63540458
Transient ischaemic attack 71.00 10.03 523 431143 43659 64023407
Asthma 70.08 10.03 363 431303 94862 63972204
Hyperkalaemia 70.05 10.03 1007 430659 100122 63966944
Presyncope 69.90 10.03 438 431228 34651 64032415
Migraine 69.19 10.03 203 431463 62474 64004592
Drug eruption 69.05 10.03 84 431582 36052 64031014
Gastrointestinal disorder 68.85 10.03 337 431329 89372 63977694
Hepatic cytolysis 68.85 10.03 7 431659 14042 64053024
Intentional product use issue 68.80 10.03 366 431300 94998 63972068
Stomatitis 68.76 10.03 440 431226 109165 63957901
Urticaria 68.23 10.03 643 431023 146674 63920392
Nodal rhythm 68.12 10.03 90 431576 2784 64064282
Eosinophilia 68.12 10.03 93 431573 37983 64029083
Cytomegalovirus infection 67.42 10.03 90 431576 37109 64029957
Dyspnoea exertional 65.72 10.03 769 430897 72961 63994105
Haemoglobin decreased 65.05 10.03 1738 429928 193325 63873741
Mitral valve incompetence 64.79 10.03 340 431326 25198 64041868
Haematoma 64.63 10.03 530 431136 45720 64021346
Mental status changes 63.74 10.03 658 431008 60504 64006562
Febrile bone marrow aplasia 62.66 10.03 3 431663 11252 64055814
Rash maculo-papular 62.17 10.03 139 431527 46887 64020179
Pneumocystis jirovecii pneumonia 62.06 10.03 56 431610 27578 64039488
Pulmonary renal syndrome 61.97 10.03 42 431624 537 64066529
Chronic kidney disease 61.26 10.03 625 431041 57294 64009772
Device expulsion 60.44 10.03 33 431633 21103 64045963
Nodal arrhythmia 60.42 10.03 68 431598 1775 64065291
Ventricular fibrillation 60.08 10.03 317 431349 23543 64043523
Orthostatic intolerance 59.36 10.03 63 431603 1537 64065529
Lower gastrointestinal haemorrhage 58.66 10.03 216 431450 13723 64053343
Pruritus 58.27 10.03 1618 430048 310782 63756284
Abdominal discomfort 58.10 10.03 864 430802 181458 63885608
Pulmonary oedema 57.95 10.03 792 430874 77882 63989184
Acute generalised exanthematous pustulosis 57.38 10.03 12 431654 14046 64053020
Injection site pain 55.63 10.03 477 431189 110931 63956135
Pathogen resistance 54.86 10.03 9 431657 12534 64054532
Anhedonia 54.86 10.03 209 431457 13497 64053569
Unresponsive to stimuli 54.35 10.03 546 431120 49847 64017219
Progressive multifocal leukoencephalopathy 54.31 10.03 27 431639 18205 64048861
Anaemia 54.10 10.03 3074 428592 375606 63691460
Haemophagocytic lymphohistiocytosis 54.10 10.03 25 431641 17584 64049482
Ejection fraction 53.78 10.03 54 431612 1232 64065834
Pallor 53.43 10.03 443 431223 38338 64028728
Ischaemic stroke 52.68 10.03 354 431312 28681 64038385
Toxic skin eruption 52.45 10.03 32 431634 19252 64047814
Anaphylactic reaction 52.08 10.03 259 431407 68405 63998661
Septic shock 51.94 10.03 453 431213 104984 63962082
Haemorrhage intracranial 51.93 10.03 305 431361 23579 64043487
Arteriosclerosis 51.59 10.03 227 431439 15650 64051416
Fear 51.48 10.03 269 431397 19902 64047164
Bone erosion 51.43 10.03 8 431658 11587 64055479
Red blood cell sedimentation rate increased 51.27 10.03 81 431585 31154 64035912
Rheumatoid nodule 51.23 10.03 11 431655 12640 64054426
Blood pressure inadequately controlled 51.06 10.03 112 431554 5272 64061794
Lymphopenia 50.78 10.03 58 431608 25599 64041467
Cholestasis 50.50 10.03 144 431522 44728 64022338
Inflammation 50.28 10.03 245 431421 65055 64002011
Atrioventricular block first degree 50.02 10.03 172 431494 10562 64056504
Therapeutic product effect incomplete 49.48 10.03 448 431218 103034 63964032
Cerebral haemorrhage 49.20 10.03 541 431125 50549 64016517
Ill-defined disorder 49.11 10.03 142 431524 43910 64023156
Myxoedema coma 48.98 10.03 39 431627 648 64066418
Peripheral arterial occlusive disease 48.67 10.03 129 431537 6858 64060208
Acute kidney injury 48.59 10.03 3561 428105 445679 63621387
Liver disorder 48.50 10.03 188 431478 53163 64013903
Atrial thrombosis 48.48 10.03 79 431587 2963 64064103
Infective pulmonary exacerbation of cystic fibrosis 48.29 10.03 10 431656 11786 64055280
Mobility decreased 48.18 10.03 356 431310 85484 63981582
Myelosuppression 48.11 10.03 53 431613 23777 64043289
Haematotoxicity 46.85 10.03 14 431652 12882 64054184
Blood pressure increased 46.45 10.03 1497 430169 171055 63896011
Immune reconstitution inflammatory syndrome 46.29 10.03 13 431653 12457 64054609
Gout 45.63 10.03 272 431394 21141 64045925
Injection site erythema 45.53 10.03 282 431384 70518 63996548
Coagulopathy 45.25 10.03 367 431299 31553 64035513
Coma 45.14 10.03 372 431294 87243 63979823
Hyperthermia 44.87 10.03 24 431642 15526 64051540
Aortic stenosis 44.83 10.03 118 431548 6247 64060819
Blood glucose increased 44.75 10.03 913 430753 97160 63969906
Arteriosclerosis coronary artery 44.51 10.03 214 431452 15315 64051751
Sinus node dysfunction 44.49 10.03 123 431543 6705 64060361
Tendonitis 44.48 10.03 42 431624 20240 64046826
Acute graft versus host disease 43.31 10.03 5 431661 9079 64057987
Hypoglycaemia 43.07 10.03 843 430823 89049 63978017
Plasma cell myeloma 43.04 10.03 485 431181 45590 64021476
Ventricular extrasystoles 42.85 10.03 231 431435 17298 64049768
Agranulocytosis 42.79 10.03 123 431543 38106 64028960
Troponin increased 42.55 10.03 210 431456 15189 64051877
Sensitisation 42.26 10.03 55 431611 1676 64065390
Cardiovascular disorder 42.07 10.03 214 431452 15667 64051399
Ventricular hypokinesia 42.05 10.03 131 431535 7638 64059428
Sedation 41.73 10.03 140 431526 41322 64025744
Bronchopulmonary aspergillosis 41.30 10.03 40 431626 19045 64048021
Haematuria 40.62 10.03 599 431067 59872 64007194
Neutropenic sepsis 40.47 10.03 58 431608 23214 64043852
Hip arthroplasty 40.40 10.03 50 431616 21301 64045765
Internal haemorrhage 40.32 10.03 128 431538 7539 64059527
Wound 40.18 10.03 323 431343 76154 63990912
Circulatory collapse 40.07 10.03 373 431293 33359 64033707
Hyperlipidaemia 39.82 10.03 277 431389 22699 64044367
Sinus arrest 39.76 10.03 73 431593 3017 64064049
Condition aggravated 39.55 10.03 2063 429603 370363 63696703
Torsade de pointes 39.23 10.03 224 431442 17139 64049927
Mouth ulceration 38.85 10.03 101 431565 32343 64034723
Ventricular arrhythmia 38.28 10.03 123 431543 7292 64059774
Aspergillus infection 38.23 10.03 32 431634 16347 64050719
Heart rate irregular 38.22 10.03 314 431352 27099 64039967
Pericardial haemorrhage 38.05 10.03 85 431581 4051 64063015
Panniculitis 37.46 10.03 7 431659 8872 64058194
Neuroleptic malignant syndrome 37.19 10.03 69 431597 24927 64042139
Supraventricular tachycardia 37.03 10.03 235 431431 18672 64048394
Malignant neoplasm progression 36.94 10.03 532 431134 112339 63954727
Pacemaker generated rhythm 36.85 10.03 15 431651 58 64067008
Heart rate abnormal 36.13 10.03 94 431572 4941 64062125
Post procedural haemorrhage 36.13 10.03 172 431494 12259 64054807
Therapeutic response decreased 35.60 10.03 204 431462 51984 64015082
Nephrogenic systemic fibrosis 35.33 10.03 103 431563 5789 64061277
Bundle branch block left 35.33 10.03 147 431519 9887 64057179
Acute respiratory failure 35.27 10.03 499 431167 49435 64017631
Heart rate decreased 35.25 10.03 541 431125 54526 64012540
Anaphylactic shock 35.11 10.03 96 431570 30232 64036834
Lactic acidosis 35.07 10.03 592 431074 60818 64006248
Malaise 35.02 10.03 2234 429432 394013 63673053
Cardiac failure chronic 34.66 10.03 136 431530 8905 64058161
Unevaluable event 34.65 10.03 502 431164 49987 64017079
Angioedema 34.59 10.03 594 431072 61227 64005839
Sedation complication 34.55 10.03 13 431653 10341 64056725
Bradyarrhythmia 34.31 10.03 77 431589 3681 64063385
Device interaction 34.25 10.03 32 431634 666 64066400
Haemorrhage 34.01 10.03 732 430934 78619 63988447
Unintentional medical device removal 33.94 10.03 3 431663 6731 64060335
Glomerular filtration rate decreased 33.94 10.03 236 431430 19336 64047730
Aortic valve incompetence 33.57 10.03 127 431539 8174 64058892
Psoriatic arthropathy 33.54 10.03 162 431504 43119 64023947
Gastrointestinal tract mucosal pigmentation 33.50 10.03 36 431630 891 64066175
Graft versus host disease 33.47 10.03 26 431640 13787 64053279
Disseminated intravascular coagulation 33.40 10.03 108 431558 32240 64034826
Cardiac valve disease 33.27 10.03 93 431573 5102 64061964
Epistaxis 33.15 10.03 876 430790 97255 63969811
Product administration error 33.00 10.03 306 431360 27337 64039729
Venoocclusive liver disease 32.71 10.03 13 431653 10002 64057064
Peripheral vascular disorder 32.66 10.03 115 431551 7146 64059920
Hypervolaemia 32.65 10.03 396 431270 37889 64029177
Myocardial depression 32.58 10.03 27 431639 476 64066590
Thrombocytopenia 32.57 10.03 1197 430469 222604 63844462
Blood pressure decreased 32.52 10.03 781 430885 85418 63981648
Orthopnoea 32.30 10.03 134 431532 9000 64058066
Hepatitis 32.28 10.03 176 431490 45406 64021660
Cardiac pacemaker insertion 32.25 10.03 90 431576 4933 64062133
Occult blood positive 32.19 10.03 104 431562 6183 64060883
Diverticulum intestinal haemorrhagic 32.14 10.03 69 431597 3200 64063866
Acute graft versus host disease in skin 32.12 10.03 4 431662 6851 64060215
Tricuspid valve incompetence 31.86 10.03 209 431457 16794 64050272
Polycystic ovaries 31.72 10.03 54 431612 2101 64064965
Decorticate posture 31.58 10.03 22 431644 295 64066771
Toxic epidermal necrolysis 31.25 10.03 135 431531 37031 64030035
Chronic graft versus host disease 31.09 10.03 3 431663 6273 64060793
Thrombosis 31.03 10.03 654 431012 69988 63997078
Epstein-Barr virus infection 30.91 10.03 23 431643 12465 64054601
Lymphocyte count decreased 30.58 10.03 154 431512 40545 64026521
Arterial haemorrhage 30.35 10.03 54 431612 2177 64064889
Impaired healing 30.14 10.03 259 431407 60214 64006852
Cardioversion 30.11 10.03 49 431617 1836 64065230
Full blood count decreased 30.06 10.03 256 431410 22326 64044740
Pulmonary hypertension 30.03 10.03 430 431236 42709 64024357
Multiple-drug resistance 29.97 10.03 4 431662 6498 64060568
Blood test abnormal 29.91 10.03 168 431498 12775 64054291
Granuloma skin 29.83 10.03 3 431663 6071 64060995
End stage renal disease 29.77 10.03 144 431522 10331 64056735
Low density lipoprotein abnormal 29.44 10.03 21 431645 293 64066773
Injection site reaction 29.42 10.03 187 431479 46477 64020589
Tachyarrhythmia 29.35 10.03 98 431568 5928 64061138
Blue toe syndrome 29.33 10.03 27 431639 551 64066515
Therapy partial responder 29.30 10.03 16 431650 10232 64056834
Fluid retention 29.23 10.03 561 431105 59045 64008021
Immunodeficiency 29.23 10.03 39 431627 16085 64050981
Dystonia 29.03 10.03 51 431615 18814 64048252
Cardiac failure acute 28.89 10.03 198 431468 16146 64050920
Coronary artery dissection 28.86 10.03 33 431633 877 64066189
Heart rate increased 28.63 10.03 864 430802 97811 63969255
Vomiting 28.54 10.03 3241 428425 547876 63519190
Essential hypertension 28.50 10.03 88 431578 5106 64061960
Hypertension 28.45 10.03 2058 429608 257203 63809863
Aggression 28.26 10.03 187 431479 46045 64021021
Poor venous access 28.08 10.03 25 431641 12392 64054674
Aphthous ulcer 27.98 10.03 27 431639 12879 64054187
Pleural effusion 27.60 10.03 1072 430594 125487 63941579
Knee arthroplasty 27.28 10.03 91 431575 26908 64040158
Intentional self-injury 27.27 10.03 101 431565 28943 64038123
Acute lung injury 27.26 10.03 58 431608 2673 64064393
Ageusia 27.24 10.03 172 431494 13641 64053425
Ischaemic cardiomyopathy 27.14 10.03 104 431562 6734 64060332
Pharyngitis 27.07 10.03 54 431612 18985 64048081
Chronotropic incompetence 26.74 10.03 13 431653 83 64066983
Tuberculosis 26.32 10.03 29 431637 13009 64054057
Renal impairment 26.31 10.03 1130 430536 133887 63933179
Nodule 26.30 10.03 50 431616 17897 64049169
Acute left ventricular failure 26.27 10.03 39 431627 1348 64065718
Atrial tachycardia 26.11 10.03 67 431599 3492 64063574
Pulmonary tuberculosis 26.07 10.03 8 431658 7236 64059830
Poisoning deliberate 26.01 10.03 31 431635 13427 64053639
Pancytopenia 25.96 10.03 745 430921 142564 63924502
Irritability 25.95 10.03 142 431524 36604 64030462
Uveitis 25.95 10.03 28 431638 12680 64054386
Melaena 25.92 10.03 503 431163 53045 64014021
Alanine aminotransferase increased 25.89 10.03 720 430946 138311 63928755
Device capturing issue 25.77 10.03 10 431656 33 64067033
Injection site pruritus 25.72 10.03 148 431518 37678 64029388
Drug dependence 25.63 10.03 125 431541 33187 64033879
Atrioventricular block second degree 25.49 10.03 98 431568 6356 64060710
Electrocardiogram T wave abnormal 25.48 10.03 64 431602 3292 64063774
Cardiac output decreased 25.48 10.03 43 431623 1661 64065405
Electrocardiogram abnormal 25.44 10.03 166 431500 13315 64053751
Seizure 25.32 10.03 888 430778 166004 63901062
Weight increased 25.31 10.03 1168 430498 212180 63854886
Upper gastrointestinal haemorrhage 25.29 10.03 353 431313 34867 64032199
Ovarian cyst 25.13 10.03 22 431644 10996 64056070
Cystitis haemorrhagic 24.90 10.03 11 431655 7945 64059121
Chromaturia 24.87 10.03 246 431420 22365 64044701
Bronchiectasis 24.83 10.03 35 431631 14105 64052961
Live birth 24.81 10.03 23 431643 11181 64055885
Hip fracture 24.74 10.03 284 431382 26815 64040251
Product quality issue 24.45 10.03 306 431360 29493 64037573
Hiatus hernia 24.37 10.03 222 431444 19735 64047331
Vascular stent thrombosis 24.34 10.03 63 431603 3301 64063765
Idiopathic pulmonary fibrosis 24.31 10.03 68 431598 3732 64063334
Product solubility abnormal 24.23 10.03 29 431637 810 64066256
Hypogammaglobulinaemia 24.18 10.03 20 431646 10279 64056787
Cardiomyopathy 24.18 10.03 268 431398 25088 64041978
Degenerative aortic valve disease 24.10 10.03 13 431653 106 64066960
Stent placement 24.01 10.03 87 431579 5484 64061582
Epilepsy 24.00 10.03 129 431537 33402 64033664
Body tinea 23.97 10.03 36 431630 1257 64065809
Forced expiratory volume decreased 23.97 10.03 8 431658 6859 64060207
Lung disorder 23.96 10.03 275 431391 60425 64006641
Thrombotic microangiopathy 23.88 10.03 47 431619 16608 64050458
Aortic valve sclerosis 23.81 10.03 40 431626 1539 64065527
Blood albumin abnormal 23.78 10.03 25 431641 603 64066463
Cardiac operation 23.69 10.03 72 431594 4142 64062924
Hypovolaemia 23.57 10.03 181 431485 15305 64051761
Serotonin syndrome 23.46 10.03 160 431506 39122 64027944
Blood parathyroid hormone decreased 23.35 10.03 10 431656 7356 64059710
Foot deformity 23.30 10.03 47 431619 16457 64050609
Abnormal behaviour 23.16 10.03 131 431535 33491 64033575
Substance abuse 23.14 10.03 17 431649 9275 64057791
Post transplant lymphoproliferative disorder 23.08 10.03 18 431648 9526 64057540
Cardiac ablation 22.97 10.03 42 431624 1730 64065336
International normalised ratio decreased 22.86 10.03 105 431561 7373 64059693
Pneumonia aspiration 22.83 10.03 270 431396 59001 64008065
Electrocardiogram RR interval prolonged 22.81 10.03 7 431659 8 64067058
Erythema multiforme 22.78 10.03 44 431622 15657 64051409
Generalised tonic-clonic seizure 22.50 10.03 165 431501 39692 64027374
Graft versus host disease in gastrointestinal tract 22.48 10.03 5 431661 5607 64061459
Therapy non-responder 22.48 10.03 308 431358 65591 64001475
Cardiomegaly 22.43 10.03 250 431416 23434 64043632
Device dislocation 22.36 10.03 70 431596 21108 64045958
Penis injury 22.30 10.03 13 431653 125 64066941
Hepatitis B 22.28 10.03 12 431654 7733 64059333
Blood potassium increased 22.27 10.03 269 431397 25711 64041355
Diffuse large B-cell lymphoma 22.09 10.03 22 431644 10339 64056727
Rectal haemorrhage 22.09 10.03 556 431110 61261 64005805
Fracture 22.08 10.03 207 431459 18548 64048518
Device adhesion issue 22.07 10.03 4 431662 5182 64061884
Agitation 21.91 10.03 438 431228 87929 63979137
Status epilepticus 21.90 10.03 73 431593 21590 64045476
Fatigue 21.74 10.03 5482 426184 743248 63323818
Pulseless electrical activity 21.73 10.03 153 431513 12586 64054480
Basal ganglia haemorrhage 21.71 10.03 36 431630 1370 64065696
Systemic infection 21.69 10.03 71 431595 4250 64062816
Allergic reaction to excipient 21.69 10.03 16 431650 236 64066830
Chronic obstructive pulmonary disease 21.67 10.03 626 431040 70422 63996644
Lymphoproliferative disorder 21.58 10.03 4 431662 5099 64061967
Body height decreased 21.58 10.03 104 431562 7450 64059616
Ejection fraction decreased 21.54 10.03 290 431376 28417 64038649
Oral herpes 21.48 10.03 76 431590 22076 64044990
Product substitution issue 21.46 10.03 198 431468 17663 64049403
Electrocardiogram QRS complex prolonged 21.37 10.03 120 431546 9124 64057942
Rash erythematous 21.34 10.03 215 431451 48418 64018648
Blood pressure systolic abnormal 21.32 10.03 21 431645 9921 64057145
Dyskinesia 21.31 10.03 165 431501 39223 64027843
Drug use disorder 21.23 10.03 7 431659 6047 64061019
Drug-disease interaction 21.21 10.03 26 431640 745 64066321
Acne 21.19 10.03 81 431585 23000 64044066
Aplasia 21.16 10.03 10 431656 6943 64060123
Haemarthrosis 21.14 10.03 80 431586 5149 64061917
Human herpesvirus 6 infection 21.13 10.03 3 431663 4651 64062415
Mucosal haemorrhage 21.12 10.03 47 431619 2234 64064832
Tooth erosion 21.12 10.03 19 431647 376 64066690
Electrolyte imbalance 21.04 10.03 260 431406 24983 64042083
Coronary artery restenosis 21.00 10.03 34 431632 1268 64065798
Flushing 20.98 10.03 385 431281 78263 63988803
CD30 expression 20.96 10.03 9 431657 41 64067025
Bundle branch block right 20.96 10.03 129 431537 10140 64056926
Hypomania 20.79 10.03 6 431660 5648 64061418
Leukopenia 20.77 10.03 517 431149 100725 63966341
Aortic aneurysm 20.72 10.03 103 431563 7471 64059595
Implantable defibrillator insertion 20.68 10.03 26 431640 765 64066301
Hypoaesthesia 20.67 10.03 742 430924 138366 63928700
Pulse absent 20.60 10.03 116 431550 8830 64058236
Amenorrhoea 20.53 10.03 9 431657 6530 64060536
Exercise tolerance decreased 20.49 10.03 104 431562 7606 64059460
Hypertensive heart disease 20.46 10.03 64 431602 3740 64063326
Cytomegalovirus chorioretinitis 20.45 10.03 4 431662 4908 64062158
Hypoalbuminaemia 20.42 10.03 56 431610 17618 64049448
Hepatitis B reactivation 20.31 10.03 4 431662 4885 64062181
Lymphadenopathy 20.24 10.03 207 431459 46479 64020587
Hypoperfusion 20.23 10.03 47 431619 2299 64064767
Injection site swelling 20.21 10.03 178 431488 41175 64025891
Colitis 20.09 10.03 274 431392 58400 64008666
Neuropathy peripheral 20.03 10.03 616 431050 116909 63950157
Hyperammonaemia 20.02 10.03 22 431644 9882 64057184
Prostatomegaly 19.88 10.03 54 431612 2913 64064153
Hypomagnesaemia 19.79 10.03 356 431310 37020 64030046
Labile hypertension 19.76 10.03 21 431645 513 64066553
Product residue present 19.75 10.03 57 431609 3185 64063881
Diverticulum intestinal 19.66 10.03 100 431566 7320 64059746
Drug level increased 19.65 10.03 330 431336 33866 64033200
Neuropathy vitamin B12 deficiency 19.64 10.03 8 431658 31 64067035
QRS axis abnormal 19.64 10.03 40 431626 1787 64065279
Obstructive airways disorder 19.62 10.03 84 431582 23101 64043965
Non-cardiac chest pain 19.62 10.03 112 431554 8568 64058498
Loss of employment 19.61 10.03 41 431625 1866 64065200
Embolic stroke 19.61 10.03 93 431573 6618 64060448
Non-cardiogenic pulmonary oedema 19.55 10.03 33 431633 1275 64065791
Cerebrospinal fluid retention 19.46 10.03 10 431656 73 64066993
Carotid artery occlusion 19.27 10.03 65 431601 3952 64063114
Extrasystoles 19.26 10.03 92 431574 6566 64060500
Metastases to bone 19.22 10.03 71 431595 20364 64046702
Respiratory tract infection 19.18 10.03 159 431507 37248 64029818
Vascular resistance pulmonary decreased 19.13 10.03 10 431656 76 64066990
Gastrointestinal arteriovenous malformation 19.09 10.03 27 431639 892 64066174
Graft versus host disease in skin 19.07 10.03 6 431660 5341 64061725
Carcinoma in situ of skin 19.00 10.03 13 431653 169 64066897
Dizziness postural 18.97 10.03 121 431545 9631 64057435
Intraventricular haemorrhage 18.87 10.03 66 431600 4087 64062979
Penile haemorrhage 18.87 10.03 20 431646 487 64066579
Diverticulum 18.84 10.03 152 431514 13046 64054020
Blood glucose decreased 18.78 10.03 237 431429 22886 64044180
Blood creatine increased 18.71 10.03 106 431560 8086 64058980
Drug tolerance decreased 18.50 10.03 12 431654 6986 64060080
Haemorrhagic stroke 18.45 10.03 122 431544 9829 64057237
Thrombin time prolonged 18.45 10.03 16 431650 301 64066765
Subchondral insufficiency fracture 18.44 10.03 9 431657 58 64067008
Carotid artery stenosis 18.30 10.03 103 431563 7838 64059228
Hepatojugular reflux 18.23 10.03 20 431646 507 64066559
Antiacetylcholine receptor antibody positive 18.19 10.03 9 431657 60 64067006
Oropharyngeal pain 18.17 10.03 454 431212 88413 63978653
Anticoagulation drug level above therapeutic 18.04 10.03 53 431613 2992 64064074
Drug withdrawal syndrome 17.92 10.03 129 431537 31162 64035904
Oral candidiasis 17.92 10.03 87 431579 23125 64043941
Lacunar infarction 17.90 10.03 79 431587 5453 64061613
Ischaemic hepatitis 17.82 10.03 55 431611 3191 64063875
Mitral valve disease 17.67 10.03 48 431618 2590 64064476
Dysgeusia 17.66 10.03 426 431240 46621 64020445
Nocardiosis 17.64 10.03 5 431661 4762 64062304
Macrophages increased 17.61 10.03 13 431653 192 64066874
Bacterial parotitis 17.57 10.03 6 431660 12 64067054
Femur fracture 17.54 10.03 145 431521 33990 64033076
Disease recurrence 17.52 10.03 131 431535 31379 64035687
Faeces pale 17.44 10.03 47 431619 2524 64064542
Blood potassium decreased 17.41 10.03 373 431293 40026 64027040
Osteonecrosis 17.35 10.03 114 431552 28115 64038951
White blood cell count decreased 17.34 10.03 871 430795 156966 63910100
High density lipoprotein decreased 17.32 10.03 62 431604 3884 64063182
Device use error 17.23 10.03 11 431655 6460 64060606
Immune thrombocytopenia 17.21 10.03 48 431618 15018 64052048
Orthostatic hypotension 17.18 10.03 422 431244 46316 64020750
Subarachnoid haemorrhage 17.18 10.03 194 431472 18244 64048822
Enterocolitis 17.16 10.03 34 431632 11984 64055082
Muscle necrosis 17.15 10.03 30 431636 1193 64065873
Somnolence 17.12 10.03 1153 430513 202492 63864574
Extrapyramidal disorder 17.07 10.03 70 431596 19482 64047584
Leukoencephalopathy 17.03 10.03 13 431653 6954 64060112
Cerebral artery occlusion 17.00 10.03 35 431631 1576 64065490
Skin induration 16.98 10.03 64 431602 4111 64062955
Oesophageal obstruction 16.92 10.03 24 431642 795 64066271
Herpes zoster 16.89 10.03 402 431264 78785 63988281
Shock 16.78 10.03 354 431312 37886 64029180
Left atrial enlargement 16.72 10.03 27 431639 1005 64066061
Transplant rejection 16.67 10.03 60 431606 17341 64049725
Neurotoxicity 16.67 10.03 111 431555 27293 64039773
Left-to-right cardiac shunt 16.66 10.03 10 431656 102 64066964
Herpes simplex 16.66 10.03 28 431638 10508 64056558
Hyperbilirubinaemia 16.64 10.03 79 431587 21126 64045940
Mitral valve sclerosis 16.52 10.03 14 431652 255 64066811
Autoimmune myositis 16.49 10.03 12 431654 173 64066893
Wheezing 16.39 10.03 412 431254 80167 63986899
Demyelination 16.39 10.03 13 431653 6821 64060245
Multiple injuries 16.38 10.03 54 431612 3245 64063821
Acute myeloid leukaemia 16.33 10.03 112 431554 27351 64039715
Nephrectomy 16.32 10.03 32 431634 1390 64065676
Traumatic haemorrhage 16.29 10.03 28 431638 1098 64065968
Osteonecrosis of jaw 16.28 10.03 179 431487 39646 64027420
Dialysis 16.21 10.03 179 431487 16741 64050325
Obsessive-compulsive disorder 16.16 10.03 6 431660 4812 64062254
Albumin urine present 16.13 10.03 21 431645 640 64066426
Secretion discharge 16.11 10.03 35 431631 11929 64055137
Posterior reversible encephalopathy syndrome 16.02 10.03 89 431577 22857 64044209
Metabolic syndrome 16 10.03 43 431623 2305 64064761
Tachycardia 15.99 10.03 1185 430481 148394 63918672
Heart valve incompetence 15.96 10.03 48 431618 2745 64064321
Osmolar gap increased 15.95 10.03 7 431659 34 64067032
Accidental exposure to product 15.93 10.03 107 431559 26257 64040809
Hypoaldosteronism 15.91 10.03 15 431651 316 64066750
Duodenal ulcer 15.85 10.03 157 431509 14278 64052788
Dermatitis exfoliative generalised 15.83 10.03 10 431656 5906 64061160
Fear of injection 15.81 10.03 10 431656 5902 64061164
Cardiovascular somatic symptom disorder 15.79 10.03 7 431659 35 64067031
Heparin-induced thrombocytopenia 15.75 10.03 104 431562 8375 64058691
Upper motor neurone lesion 15.74 10.03 13 431653 228 64066838
Dermatitis acneiform 15.74 10.03 20 431646 8423 64058643
Blood urea increased 15.73 10.03 397 431269 43756 64023310
Central nervous system lesion 15.68 10.03 35 431631 11814 64055252
Blood sodium decreased 15.67 10.03 281 431385 29201 64037865
Gastrointestinal toxicity 15.67 10.03 8 431658 5314 64061752
Appendicitis 15.67 10.03 43 431623 13526 64053540
Hypertransaminasaemia 15.64 10.03 15 431651 7176 64059890
Muscle spasticity 15.62 10.03 58 431608 16611 64050455
Ulcer 15.61 10.03 90 431576 22900 64044166
Loss of personal independence in daily activities 15.40 10.03 368 431298 72086 63994980
Actinic keratosis 15.40 10.03 72 431594 5093 64061973
Blood pressure abnormal 15.37 10.03 156 431510 14279 64052787
Retroperitoneal haemorrhage 15.36 10.03 69 431597 4799 64062267
Lymphatic fistula 15.35 10.03 22 431644 736 64066330
Catatonia 15.32 10.03 17 431649 7603 64059463
Neutrophil function disorder 15.20 10.03 6 431660 21 64067045
Coronary artery thrombosis 15.18 10.03 48 431618 2821 64064245
Ear infection 15.16 10.03 93 431573 23311 64043755
Exposure via ingestion 15.11 10.03 69 431597 4833 64062233
Malignant polyp 15.10 10.03 11 431655 159 64066907
Renal atrophy 15.09 10.03 34 431632 1630 64065436
Blood alkaline phosphatase abnormal 15.04 10.03 22 431644 750 64066316
Phaeochromocytoma crisis 14.92 10.03 14 431652 293 64066773
Product dose omission issue 14.90 10.03 1505 430161 193242 63873824
Incorrect route of product administration 14.87 10.03 93 431573 23205 64043861
Fibromyalgia 14.85 10.03 160 431506 35571 64031495
Phaeochromocytoma 14.83 10.03 19 431647 570 64066496
Portal fibrosis 14.80 10.03 19 431647 571 64066495
Stevens-Johnson syndrome 14.78 10.03 152 431514 34097 64032969
Peripheral sensory neuropathy 14.74 10.03 34 431632 11344 64055722
Aplastic anaemia 14.70 10.03 46 431620 13874 64053192
Thoracic haemorrhage 14.70 10.03 12 431654 207 64066859
Muscular weakness 14.67 10.03 1015 430651 126323 63940743
Diarrhoea 14.66 10.03 5216 426450 717488 63349578
Depressed mood 14.60 10.03 190 431476 40822 64026244
Thalamus haemorrhage 14.59 10.03 33 431633 1586 64065480
Haemorrhagic transformation stroke 14.55 10.03 42 431624 2347 64064719
Aortic valve stenosis 14.51 10.03 65 431601 4515 64062551
Respiratory disorder 14.49 10.03 163 431503 35948 64031118
Altered state of consciousness 14.46 10.03 173 431493 37729 64029337
Sudden cardiac death 14.46 10.03 65 431601 4522 64062544
Device related infection 14.45 10.03 133 431533 30493 64036573
Cytokine release syndrome 14.43 10.03 81 431585 20748 64046318
Grip strength decreased 14.42 10.03 36 431630 11688 64055378
Total cholesterol/HDL ratio increased 14.41 10.03 12 431654 213 64066853
Coeliac disease 14.40 10.03 17 431649 7395 64059671
Autoimmune myocarditis 14.38 10.03 13 431653 259 64066807
Pleural mass 14.36 10.03 8 431658 70 64066996
Computerised tomogram head abnormal 14.34 10.03 9 431657 100 64066966
Abdominal pain lower 14.33 10.03 253 431413 26216 64040850
Gouty arthritis 14.28 10.03 29 431637 1293 64065773
Tenderness 14.26 10.03 75 431591 19527 64047539
Electrocardiogram ST-T segment abnormal 14.25 10.03 17 431649 473 64066593
Food allergy 14.22 10.03 19 431647 7832 64059234
Chronic left ventricular failure 14.20 10.03 21 431645 723 64066343
Blood creatinine abnormal 14.17 10.03 60 431606 4067 64062999
Aspartate aminotransferase increased 14.15 10.03 656 431010 119132 63947934
Carotid artery disease 14.13 10.03 39 431627 2124 64064942
Sprue-like enteropathy 14.12 10.03 25 431641 1004 64066062
Multiple sclerosis relapse 14.12 10.03 192 431474 40943 64026123
Palmar-plantar erythrodysaesthesia syndrome 14.10 10.03 124 431542 28695 64038371
Injury 14.08 10.03 482 431184 55510 64011556
Arteriosclerotic gangrene 14.08 10.03 8 431658 73 64066993
Emotional distress 14.04 10.03 328 431338 35710 64031356
Ascites 13.99 10.03 312 431354 61689 64005377
Clonus 13.98 10.03 12 431654 6055 64061011
Schizophrenia 13.96 10.03 34 431632 11134 64055932
Prothrombin time prolonged 13.94 10.03 164 431502 15577 64051489
Mydriasis 13.89 10.03 54 431612 15258 64051808
Left ventricular hypertrophy 13.85 10.03 110 431556 9396 64057670
Cerebellar haemorrhage 13.85 10.03 44 431622 2593 64064473
Femoral hernia incarcerated 13.84 10.03 21 431645 740 64066326
Photophobia 13.82 10.03 64 431602 17229 64049837
Tumour lysis syndrome 13.79 10.03 75 431591 19365 64047701
Carcinoid tumour 13.79 10.03 16 431650 432 64066634
International normalised ratio abnormal 13.76 10.03 68 431598 4920 64062146
Mood swings 13.76 10.03 65 431601 17403 64049663
Hyperhidrosis 13.75 10.03 992 430674 123928 63943138
Disability 13.74 10.03 39 431627 12133 64054933
Haemorrhoidal haemorrhage 13.73 10.03 75 431591 5644 64061422
Left ventricular failure 13.73 10.03 100 431566 8317 64058749
Type IIa hyperlipidaemia 13.70 10.03 11 431655 185 64066881
Diabetic nephropathy 13.68 10.03 44 431622 2610 64064456
Cell death 13.68 10.03 5 431661 4049 64063017
Akathisia 13.65 10.03 36 431630 11474 64055592
Hepatitis acute 13.62 10.03 45 431621 13344 64053722
Intracranial pressure increased 13.61 10.03 16 431650 6973 64060093
Faeces discoloured 13.60 10.03 245 431421 25484 64041582
Paronychia 13.59 10.03 14 431652 6478 64060588
Shone complex 13.53 10.03 6 431660 30 64067036
Mitral valve hypoplasia 13.53 10.03 6 431660 30 64067036
Lipodystrophy acquired 13.53 10.03 5 431661 4022 64063044
Acute lymphocytic leukaemia recurrent 13.52 10.03 5 431661 4021 64063045
Paraesthesia 13.52 10.03 749 430917 133773 63933293
Mitral valve stenosis 13.52 10.03 25 431641 1039 64066027
Cytomegalovirus viraemia 13.51 10.03 33 431633 10795 64056271
Therapeutic response shortened 13.49 10.03 30 431636 10140 64056926
Parathyroid hormone-related protein abnormal 13.49 10.03 5 431661 14 64067052
Aortic arteriosclerosis 13.47 10.03 91 431575 7385 64059681
Myopathy 13.43 10.03 179 431487 17501 64049565
Seroma 13.38 10.03 37 431629 2017 64065049
Congenital aortic valve stenosis 13.37 10.03 6 431660 31 64067035
Hypertriglyceridaemia 13.32 10.03 35 431631 11170 64055896
Dilatation atrial 13.31 10.03 52 431614 3398 64063668
Aorta hypoplasia 13.22 10.03 6 431660 32 64067034
Inspiratory capacity abnormal 13.21 10.03 8 431658 83 64066983
Eructation 13.20 10.03 106 431560 9085 64057981
Malignant neoplasm of eye 13.19 10.03 7 431659 55 64067011
Glucose tolerance impaired 13.19 10.03 81 431585 6362 64060704
Disseminated tuberculosis 13.16 10.03 4 431662 3641 64063425
Colitis ulcerative 13.16 10.03 95 431571 22933 64044133
Catheterisation cardiac 13.14 10.03 66 431600 4807 64062259
Multiple drug therapy 13.13 10.03 39 431627 2215 64064851
Conjunctivitis 13.12 10.03 81 431585 20273 64046793
Deep vein thrombosis 13.11 10.03 844 430822 104338 63962728
Aortic valve replacement 13.05 10.03 26 431640 1143 64065923
Paradoxical drug reaction 13.04 10.03 13 431653 6107 64060959
Listless 13.03 10.03 50 431616 3240 64063826
Cardiac function test abnormal 13.02 10.03 9 431657 119 64066947
Intracardiac thrombus 13.00 10.03 55 431611 3726 64063340
Throat irritation 12.99 10.03 148 431518 32563 64034503
Ejection fraction abnormal 12.95 10.03 29 431637 1384 64065682
Systemic candida 12.95 10.03 10 431656 5319 64061747
Ultrasound kidney abnormal 12.93 10.03 6 431660 34 64067032
Device difficult to use 12.92 10.03 29 431637 9769 64057297
Muscle oedema 12.90 10.03 9 431657 121 64066945
Dementia 12.90 10.03 203 431463 20563 64046503
Depressive symptom 12.88 10.03 7 431659 4489 64062577
Histology abnormal 12.83 10.03 13 431653 300 64066766
Coronary angioplasty 12.82 10.03 14 431652 353 64066713
Uterine perforation 12.82 10.03 12 431654 5808 64061258
Pruritus genital 12.80 10.03 24 431642 1008 64066058
Paranoia 12.79 10.03 61 431605 16291 64050775
Disturbance in social behaviour 12.77 10.03 5 431661 3882 64063184
Heavy menstrual bleeding 12.69 10.03 40 431626 12037 64055029
Skin hypertrophy 12.68 10.03 62 431604 4467 64062599
Renal cell carcinoma 12.66 10.03 77 431589 6027 64061039
Aspiration pleural cavity 12.65 10.03 29 431637 1406 64065660
Embolic cerebral infarction 12.63 10.03 25 431641 1094 64065972
Hypoxia 12.62 10.03 716 430950 87433 63979633
Menstruation irregular 12.57 10.03 7 431659 4428 64062638
Skin tightness 12.55 10.03 66 431600 4895 64062171
Fungal infection 12.44 10.03 158 431508 34093 64032973
Optic neuritis 12.44 10.03 22 431644 8094 64058972
Echocardiogram abnormal 12.43 10.03 33 431633 1756 64065310
Vasoconstriction 12.39 10.03 18 431648 610 64066456
Biopsy lymph gland 12.37 10.03 8 431658 94 64066972
Gastritis erosive 12.37 10.03 108 431558 9487 64057579
Renal function test abnormal 12.29 10.03 56 431610 3918 64063148
Encephalitis 12.27 10.03 43 431623 12528 64054538
Mood altered 12.27 10.03 60 431606 15919 64051147
Ulcer haemorrhage 12.23 10.03 61 431605 4431 64062635
Cardiovascular insufficiency 12.19 10.03 42 431624 2582 64064484
Hyperthyroidism 12.17 10.03 180 431486 17999 64049067
Patent ductus arteriosus 12.16 10.03 8 431658 97 64066969
Pseudomonas infection 12.14 10.03 70 431596 17813 64049253
Congenital heart valve disorder 12.13 10.03 6 431660 40 64067026
Anticoagulation drug level below therapeutic 12.11 10.03 27 431639 1285 64065781
Electrocardiogram QRS complex shortened 12.10 10.03 18 431648 623 64066443
Rhinitis allergic 12.06 10.03 94 431572 7984 64059082
Blood cholinesterase decreased 12.05 10.03 11 431655 222 64066844
Venous pressure jugular abnormal 12.04 10.03 3 431663 0 64067066
Alveolar-arterial oxygen gradient increased 12.04 10.03 3 431663 0 64067066
Diabetic dermopathy 12.04 10.03 3 431663 0 64067066
Drug screen 12.04 10.03 3 431663 0 64067066
Eosinophil count increased 12.02 10.03 51 431615 14061 64053005
Apallic syndrome 11.96 10.03 21 431645 838 64066228
Autoimmune haemolytic anaemia 11.95 10.03 18 431648 7058 64060008
Neutropenic colitis 11.91 10.03 8 431658 4573 64062493
Retching 11.81 10.03 155 431511 15101 64051965
Left ventricular dysfunction 11.80 10.03 169 431497 16785 64050281
Social avoidant behaviour 11.79 10.03 8 431658 4549 64062517
Hypercalcaemia 11.76 10.03 144 431522 31272 64035794
Myocardial hypoxia 11.71 10.03 4 431662 8 64067058
Tonsillitis 11.69 10.03 13 431653 5807 64061259
Drug abuser 11.63 10.03 13 431653 5795 64061271
Soft tissue haemorrhage 11.59 10.03 13 431653 338 64066728
JC virus infection 11.55 10.03 4 431662 3351 64063715
Ventricular hypertrophy 11.55 10.03 79 431587 6437 64060629
Hospice care 11.54 10.03 89 431577 7536 64059530
Joint stiffness 11.51 10.03 139 431527 30265 64036801
Blood pressure orthostatic 11.45 10.03 7 431659 74 64066992
Sacroiliitis 11.44 10.03 3 431663 3009 64064057
Complication of device insertion 11.44 10.03 10 431656 5002 64062064
Total cholesterol/HDL ratio decreased 11.44 10.03 5 431661 24 64067042
Iliac artery stenosis 11.44 10.03 8 431658 108 64066958
Joint destruction 11.42 10.03 5 431661 3631 64063435
Intraocular pressure increased 11.42 10.03 24 431642 8278 64058788
Polymyositis 11.41 10.03 42 431624 2668 64064398
Antithyroid arthritis syndrome 11.40 10.03 4 431662 9 64067057
Carcinoid tumour of the gastrointestinal tract 11.37 10.03 7 431659 75 64066991
Peripheral coldness 11.36 10.03 140 431526 13444 64053622
Abdominal pain 11.36 10.03 1877 429789 310498 63756568
Flatulence 11.36 10.03 316 431350 35350 64031716
Facial bones fracture 11.35 10.03 58 431608 4254 64062812
Cyanopsia 11.29 10.03 7 431659 76 64066990
Supravalvular aortic stenosis 11.28 10.03 5 431661 25 64067041
Congenital aortic stenosis 11.28 10.03 5 431661 25 64067041
Congenital aortic anomaly 11.28 10.03 5 431661 25 64067041
Post-anoxic myoclonus 11.28 10.03 5 431661 25 64067041
Pneumatosis intestinalis 11.27 10.03 11 431655 5218 64061848
Supraventricular extrasystoles 11.26 10.03 73 431593 5842 64061224
Skin fibrosis 11.26 10.03 28 431638 1431 64065635
Calciphylaxis 11.25 10.03 48 431618 3264 64063802
Cerebral ischaemia 11.25 10.03 109 431557 9853 64057213
Exostosis 11.25 10.03 39 431627 11399 64055667
Accelerated hypertension 11.25 10.03 17 431649 597 64066469
Dry eye 11.25 10.03 132 431534 28887 64038179
Ventricular dyssynchrony 11.22 10.03 6 431660 48 64067018
Arteriovenous fistula occlusion 11.21 10.03 16 431650 533 64066533
Eczema 11.21 10.03 136 431530 29584 64037482
Jaundice cholestatic 11.15 10.03 26 431640 8644 64058422
Blood pressure fluctuation 11.15 10.03 263 431403 51608 64015458
Electrocardiogram ST segment elevation 11.13 10.03 85 431581 7174 64059892
Blood creatine phosphokinase MB abnormal 11.12 10.03 5 431661 26 64067040
Negative cardiac inotropic effect 11.11 10.03 4 431662 10 64067056
Blood pressure immeasurable 11.10 10.03 33 431633 1875 64065191
Fracture blisters 11.06 10.03 7 431659 79 64066987
Haemoptysis 11.05 10.03 417 431249 48631 64018435
Ischaemia 11.04 10.03 85 431581 7193 64059873
Head injury 11.03 10.03 293 431373 32549 64034517
Urinary tract infection 11.01 10.03 1738 429928 229858 63837208
Toxicity to various agents 10.99 10.03 2667 428999 360846 63706220
Organising pneumonia 10.98 10.03 28 431638 9027 64058039
Metastatic renal cell carcinoma 10.95 10.03 36 431630 2160 64064906
Osteoporosis 10.91 10.03 207 431459 41873 64025193
Body temperature increased 10.90 10.03 176 431490 36490 64030576
Renal disorder 10.89 10.03 312 431354 35053 64032013
Immune-mediated myositis 10.85 10.03 41 431625 2637 64064429
Lupus pneumonitis 10.84 10.03 7 431659 82 64066984
Blood pressure diastolic abnormal 10.82 10.03 42 431624 11875 64055191
Galactorrhoea 10.81 10.03 4 431662 3215 64063851
Drug ineffective for unapproved indication 10.80 10.03 145 431521 30988 64036078
Splenic haemorrhage 10.76 10.03 17 431649 621 64066445
Pancreatic steatosis 10.75 10.03 22 431644 986 64066080
Suicidal behaviour 10.73 10.03 3 431663 2884 64064182
Pneumonia cytomegaloviral 10.73 10.03 8 431658 4331 64062735
Self-injurious ideation 10.69 10.03 4 431662 3193 64063873
Aortic valve disease 10.68 10.03 29 431637 1564 64065502
Chest wall haematoma 10.67 10.03 13 431653 370 64066696
Hyperlactacidaemia 10.66 10.03 10 431656 4834 64062232
Oedema due to cardiac disease 10.63 10.03 6 431660 54 64067012
Myxoedema 10.62 10.03 8 431658 122 64066944
Aortic aneurysm repair 10.59 10.03 4 431662 12 64067054
Poor peripheral circulation 10.58 10.03 46 431620 3154 64063912
Hemiparesis 10.57 10.03 268 431398 29559 64037507
Venous pressure jugular increased 10.56 10.03 25 431641 1238 64065828
Skin lesion 10.55 10.03 176 431490 36306 64030760
Respiratory depression 10.55 10.03 103 431563 23340 64043726
Blood urine present 10.54 10.03 177 431489 18163 64048903
Gastrointestinal ulcer perforation 10.54 10.03 5 431661 30 64067036
Tricuspid valve sclerosis 10.54 10.03 5 431661 30 64067036
Crying 10.48 10.03 85 431581 20005 64047061
Troponin I increased 10.48 10.03 52 431614 3769 64063297
Pancreatitis acute 10.44 10.03 213 431453 42642 64024424
Infection susceptibility increased 10.44 10.03 41 431625 2685 64064381
Pyonephrosis 10.43 10.03 7 431659 88 64066978
Brain natriuretic peptide increased 10.41 10.03 87 431579 7546 64059520
Hyperreflexia 10.40 10.03 20 431646 7128 64059938
Injection site haemorrhage 10.38 10.03 108 431558 24170 64042896
Vaginal discharge 10.37 10.03 7 431659 3990 64063076
Cystic fibrosis 10.36 10.03 5 431661 3429 64063637
Polyarthritis 10.33 10.03 32 431634 9683 64057383
Amaurosis fugax 10.30 10.03 19 431647 788 64066278
Ear pain 10.26 10.03 113 431553 25023 64042043
Haemodialysis 10.25 10.03 166 431500 16911 64050155
Meningitis aseptic 10.24 10.03 14 431652 5716 64061350
Gastric ulcer 10.23 10.03 270 431396 29964 64037102
Activated partial thromboplastin time prolonged 10.20 10.03 131 431535 12700 64054366
Hyperferritinaemia 10.20 10.03 15 431651 514 64066552
Traumatic intracranial haemorrhage 10.19 10.03 22 431644 1024 64066042
Electrocardiogram ST-T change 10.19 10.03 28 431638 1521 64065545
Conjunctival cyst 10.18 10.03 6 431660 59 64067007
Heart disease congenital 10.18 10.03 15 431651 515 64066551
Electrocardiogram ST segment depression 10.16 10.03 57 431609 4332 64062734
Cardioactive drug level increased 10.11 10.03 48 431618 3417 64063649
Vascular access site occlusion 10.10 10.03 6 431660 60 64067006
Coarctation of the aorta 10.10 10.03 6 431660 60 64067006
Coronary artery insufficiency 10.09 10.03 9 431657 176 64066890
Anal abscess 10.08 10.03 22 431644 7486 64059580
Cardiac fibrillation 10.07 10.03 20 431646 877 64066189
Rhinovirus infection 10.07 10.03 16 431650 6140 64060926
Myocardial necrosis marker increased 10.04 10.03 41 431625 2734 64064332
Gastric cyst 10.04 10.03 7 431659 94 64066972
Sputum discoloured 10.04 10.03 74 431592 17782 64049284

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neonatal respiratory failure 33.10 28.61 23 878 187 83590

Pharmacologic Action:

SourceCodeDescription
ATC C07AB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07BB52 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07CB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07FB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013565 Sympatholytics
CHEBI has role CHEBI:35530 beta-adrenergic blockers
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Angina pectoris indication 194828000
Acute coronary syndrome indication 394659003
Myocardial Reinfarction Prevention indication
Supraventricular tachycardia off-label use 6456007
Ventricular tachycardia off-label use 25569003
Atrial fibrillation off-label use 49436004 DOID:0060224
Multifocal atrial tachycardia off-label use 49982000
Paroxysmal supraventricular tachycardia off-label use 67198005
Thyrotoxicosis off-label use 90739004 DOID:7997
Paroxysmal atrial tachycardia off-label use 195069001
Ectopic atrial tachycardia off-label use 233892002
Mitral valve prolapse off-label use 409712001
Diastolic heart failure off-label use 418304008 DOID:9775
Migraine Prevention off-label use
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Pheochromocytoma Adjunct Therapy off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Myasthenia gravis contraindication 91637004 DOID:437
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Azotemia contraindication 445009001
Acute exacerbation of asthma contraindication 708038006
First Degree Atrioventricular Heart Block contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.60 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.30 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.79 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.83 CHEMBL
Adrenergic receptor beta GPCR IC50 6.30 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 7.31 CHEMBL

External reference:

IDSource
D00601 KEGG_DRUG
80274-67-5 SECONDARY_CAS_RN
98418-47-4 SECONDARY_CAS_RN
56392-17-7 SECONDARY_CAS_RN
4018393 VANDF
4019836 VANDF
4020875 VANDF
C0025859 UMLSCUI
CHEBI:6904 CHEBI
CHEMBL13 ChEMBL_ID
CHEMBL3989566 ChEMBL_ID
CHEMBL1200337 ChEMBL_ID
CHEMBL2356097 ChEMBL_ID
DB00264 DRUGBANK_ID
CHEMBL2062335 ChEMBL_ID
D008790 MESH_DESCRIPTOR_UI
4171 PUBCHEM_CID
553 IUPHAR_LIGAND_ID
3471 INN_ID
GEB06NHM23 UNII
102313 RXNORM
1073 MMSL
5102 MMSL
5103 MMSL
d00134 MMSL
001853 NDDF
003627 NDDF
003628 NDDF
004135 NDDF
372826007 SNOMEDCT_US
412432007 SNOMEDCT_US
7092007 SNOMEDCT_US
72770009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9660 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9873 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0018 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0018 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0032 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0032 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0047 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0047 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0424 TABLET 50 mg ORAL ANDA 27 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0434 TABLET 100 mg ORAL ANDA 27 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0445 TABLET 100 mg ORAL ANDA 27 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4593 TABLET, FILM COATED 37.50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4593 TABLET, FILM COATED 37.50 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4594 TABLET, FILM COATED 75 mg ORAL ANDA 23 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4594 TABLET, FILM COATED 75 mg ORAL ANDA 23 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4595 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4595 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4596 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4596 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4597 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4597 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4598 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL ANDA 30 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4598 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL ANDA 30 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1778 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 31 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1778 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 31 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-2016 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 31 sections
METOPROLOL SUCCINATE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2600 TABLET, EXTENDED RELEASE 25 mg ORAL NDA authorized generic 27 sections
METOPROLOL SUCCINATE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2601 TABLET, EXTENDED RELEASE 50 mg ORAL NDA authorized generic 27 sections
METOPROLOL SUCCINATE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2602 TABLET, EXTENDED RELEASE 100 mg ORAL NDA authorized generic 27 sections
METOPROLOL SUCCINATE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2603 TABLET, EXTENDED RELEASE 200 mg ORAL NDA authorized generic 27 sections