metoprolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 1786 51384-51-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metoprolol fumarate
  • metoprolol
  • metoprolol succinate
  • beatrolol
  • metoprolol tartrate
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
  • Molecular weight: 267.37
  • Formula: C15H25NO3
  • CLOGP: 1.49
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 50.72
  • ALOGS: -2.82
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1000 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 24.95 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 13 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.88 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1978 FDA US PHARMS HOLDINGS I

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 4467.70 30.69 1109 5394 19925 2331657
Toxicity to various agents 2216.18 30.69 711 5792 32043 2319539
Bradycardia 1598.05 30.69 425 6078 9556 2342026
Hypotension 1420.19 30.69 510 5993 31926 2319656
Syncope 778.07 30.69 277 6226 16598 2334984
Dizziness 692.41 30.69 367 6136 58298 2293284
Drug hypersensitivity 672.06 30.69 334 6169 46309 2305273
Cardiac arrest 575.44 30.69 215 6288 14715 2336867
Dyspnoea 513.74 30.69 336 6167 78397 2273185
Overdose 498.58 30.69 210 6293 19697 2331885
Intentional overdose 472.50 30.69 173 6330 11148 2340434
Fall 466.24 30.69 263 6240 46836 2304746
Blood pressure increased 437.84 30.69 183 6320 16803 2334779
Drug interaction 415.88 30.69 208 6295 28955 2322627
Medication error 412.57 30.69 134 6369 5997 2345585
Cardiogenic shock 405.36 30.69 108 6395 2383 2349199
Suicide attempt 374.84 30.69 146 6357 11136 2340446
Atrial fibrillation 373.71 30.69 154 6349 13614 2337968
Cardio-respiratory arrest 371.14 30.69 137 6366 9009 2342573
Palpitations 350.47 30.69 155 6348 16301 2335281
Drug ineffective 329.91 30.69 286 6217 101338 2250244
Hypertension 328.62 30.69 174 6329 27187 2324395
Sinus bradycardia 326.53 30.69 88 6415 2028 2349554
Foetal exposure during pregnancy 325.84 30.69 108 6395 5144 2346438
Maternal exposure during pregnancy 316.41 30.69 140 6363 14723 2336859
Fatigue 281.27 30.69 242 6261 84631 2266951
Exposure during pregnancy 279.17 30.69 152 6351 25067 2326515
Product substitution issue 270.07 30.69 93 6410 4976 2346606
Product prescribing error 266.99 30.69 81 6422 2879 2348703
Death 253.04 30.69 224 6279 81244 2270338
Respiratory arrest 248.40 30.69 92 6411 6086 2345496
Chest pain 245.05 30.69 145 6358 27992 2323590
Nausea 243.50 30.69 253 6250 111936 2239646
General physical health deterioration 240.47 30.69 114 6389 14025 2337557
Tachycardia 221.43 30.69 113 6390 16296 2335286
Condition aggravated 215.52 30.69 140 6363 31839 2319743
Blood pressure decreased 212.56 30.69 92 6411 9144 2342438
Hyperkalaemia 212.32 30.69 81 6422 5812 2345770
Poisoning 207.31 30.69 66 6437 2754 2348828
Heart rate decreased 205.71 30.69 70 6433 3606 2347976
Inappropriate schedule of product administration 194.06 30.69 94 6409 12110 2339472
Arrhythmia 192.81 30.69 76 6427 5952 2345630
Heart rate increased 190.13 30.69 90 6413 11015 2340567
Blood pressure inadequately controlled 184.87 30.69 47 6456 853 2350729
Acute kidney injury 184.20 30.69 121 6382 28001 2323581
Presyncope 184.12 30.69 65 6438 3738 2347844
Confusional state 179.82 30.69 113 6390 24231 2327351
Pulmonary oedema 171.51 30.69 74 6429 7289 2344293
Premature baby 171.40 30.69 59 6444 3145 2348437
Asthenia 169.49 30.69 141 6362 46785 2304797
Ventricular tachycardia 167.13 30.69 57 6446 2954 2348628
Malaise 166.38 30.69 150 6353 55435 2296147
Somnolence 158.48 30.69 103 6400 23382 2328200
Off label use 157.20 30.69 165 6338 73433 2278149
Atrioventricular block 157.02 30.69 44 6459 1173 2350409
Premature delivery 156.05 30.69 55 6448 3145 2348437
Orthostatic hypotension 153.93 30.69 53 6450 2826 2348756
Circulatory collapse 151.64 30.69 56 6447 3664 2347918
Coma 147.66 30.69 71 6432 8985 2342597
Caesarean section 146.59 30.69 56 6447 4025 2347557
Peripheral swelling 145.94 30.69 88 6415 17509 2334073
Loss of consciousness 145.79 30.69 90 6413 18677 2332905
Shock 144.03 30.69 55 6448 3949 2347633
Drug abuse 136.96 30.69 74 6429 11952 2339630
Respiratory depression 135.93 30.69 45 6458 2125 2349457
Anuria 135.30 30.69 43 6460 1781 2349801
Decorticate posture 135.07 30.69 22 6481 24 2351558
Vomiting 134.37 30.69 150 6353 71452 2280130
Oedema peripheral 133.40 30.69 93 6410 23670 2327912
Myocardial depression 132.26 30.69 23 6480 48 2351534
Ventricular extrasystoles 132.13 30.69 43 6460 1923 2349659
Hypoglycaemia 131.28 30.69 64 6439 8343 2343239
Nodal rhythm 130.13 30.69 30 6473 352 2351230
Electrocardiogram QT prolonged 129.61 30.69 62 6441 7752 2343830
Heart rate irregular 127.10 30.69 44 6459 2383 2349199
Low birth weight baby 125.55 30.69 34 6469 795 2350787
Cardiac failure 122.79 30.69 69 6434 12025 2339557
Metabolic acidosis 122.55 30.69 55 6448 5943 2345639
Intentional product misuse 121.06 30.69 63 6440 9426 2342156
Insomnia 119.82 30.69 90 6413 25697 2325885
Feeling abnormal 117.86 30.69 86 6417 23495 2328087
Unresponsive to stimuli 116.77 30.69 50 6453 4826 2346756
Acute myocardial infarction 115.03 30.69 50 6453 5005 2346577
Torsade de pointes 114.84 30.69 40 6463 2206 2349376
Angioedema 113.60 30.69 58 6445 8338 2343244
Product administration error 113.14 30.69 46 6457 3897 2347685
Depressed level of consciousness 113.07 30.69 56 6447 7548 2344034
Hyponatraemia 111.36 30.69 67 6436 13258 2338324
Ventricular hypokinesia 110.76 30.69 29 6474 593 2350989
Dehydration 108.44 30.69 80 6423 22215 2329367
Atrial flutter 108.36 30.69 33 6470 1184 2350398
Left ventricular dysfunction 107.75 30.69 33 6470 1207 2350375
Decreased appetite 106.55 30.69 88 6415 28803 2322779
Labelled drug-drug interaction medication error 106.01 30.69 33 6470 1275 2350307
Chest discomfort 105.74 30.69 67 6436 14528 2337054
Myocardial infarction 105.69 30.69 74 6429 18939 2332643
Deep vein thrombosis 105.42 30.69 64 6439 12868 2338714
Lymphatic fistula 104.22 30.69 16 6487 7 2351575
Conjoined twins 101.07 30.69 16 6487 12 2351570
Femoral hernia incarcerated 100.51 30.69 16 6487 13 2351569
Ejection fraction decreased 99.00 30.69 38 6465 2763 2348819
Hypothermia 97.43 30.69 35 6468 2113 2349469
Pancreatic steatosis 96.95 30.69 17 6486 38 2351544
Blood creatinine increased 95.93 30.69 56 6447 10477 2341105
Cough 94.18 30.69 87 6416 33030 2318552
Blood pressure systolic increased 90.86 30.69 34 6469 2305 2349277
Arthralgia 90.29 30.69 107 6396 54178 2297404
Hypoxia 90.02 30.69 45 6458 6182 2345400
Product quality issue 89.29 30.69 54 6449 10775 2340807
Foetal growth restriction 89.20 30.69 28 6475 1112 2350470
Anxiety 89.08 30.69 80 6423 29279 2322303
Myalgia 87.93 30.69 72 6431 23261 2328321
Congenital hydronephrosis 87.37 30.69 16 6487 50 2351532
Headache 86.87 30.69 128 6375 80051 2271531
Cardiotoxicity 86.73 30.69 28 6475 1219 2350363
Hyperhidrosis 85.62 30.69 60 6443 15362 2336220
Ventricular fibrillation 85.51 30.69 32 6471 2169 2349413
Coma scale abnormal 85.03 30.69 25 6478 793 2350789
Drug intolerance 84.73 30.69 57 6446 13660 2337922
Diarrhoea 84.26 30.69 129 6374 83435 2268147
Wound infection pseudomonas 83.14 30.69 16 6487 70 2351512
Abdominal discomfort 81.17 30.69 61 6442 17395 2334187
Mitral valve incompetence 80.93 30.69 32 6471 2518 2349064
Atrioventricular block first degree 80.90 30.69 25 6478 942 2350640
Atrial septal defect 80.68 30.69 27 6476 1317 2350265
Muscular weakness 80.47 30.69 57 6446 14840 2336742
Allergic reaction to excipient 80.27 30.69 15 6488 54 2351528
Pulmonary hypertension 79.96 30.69 39 6464 5079 2346503
Acute respiratory distress syndrome 79.60 30.69 34 6469 3258 2348324
Tinnitus 76.85 30.69 38 6465 5097 2346485
Small for dates baby 76.48 30.69 22 6481 645 2350937
Back pain 76.40 30.69 76 6427 31583 2319999
Atrioventricular block complete 75.43 30.69 26 6477 1388 2350194
Arterial haemorrhage 75.15 30.69 17 6486 182 2351400
Pain 73.13 30.69 103 6400 61754 2289828
Exposure via ingestion 72.85 30.69 22 6481 766 2350816
Atrioventricular block second degree 71.72 30.69 21 6482 656 2350926
Intestinal malrotation 71.13 30.69 13 6490 40 2351542
Product monitoring error 70.91 30.69 15 6488 114 2351468
Aortic valve stenosis 70.90 30.69 18 6485 324 2351258
Placental insufficiency 70.75 30.69 17 6486 241 2351341
Urachal abnormality 70.22 30.69 11 6492 7 2351575
Cardiac failure acute 69.85 30.69 23 6480 1066 2350516
Gait disturbance 69.46 30.69 62 6441 22483 2329099
Ventricular arrhythmia 69.18 30.69 20 6483 597 2350985
Premature labour 68.84 30.69 27 6476 2079 2349503
Eructation 68.38 30.69 23 6480 1139 2350443
Tachyarrhythmia 68.33 30.69 20 6483 624 2350958
Blood pressure fluctuation 68.27 30.69 26 6477 1849 2349733
Persistent cloaca 67.53 30.69 11 6492 12 2351570
Accidental overdose 67.29 30.69 32 6471 3940 2347642
Diverticulum intestinal 67.20 30.69 20 6483 662 2350920
Orthostatic intolerance 66.79 30.69 15 6488 155 2351427
Musculoskeletal stiffness 66.45 30.69 47 6456 12200 2339382
Labile hypertension 65.96 30.69 13 6490 66 2351516
Cardiovascular disorder 65.92 30.69 27 6476 2328 2349254
Congenital bladder anomaly 65.36 30.69 11 6492 17 2351565
Discomfort 65.03 30.69 34 6469 5125 2346457
Bradyarrhythmia 64.76 30.69 17 6486 351 2351231
Seroma 64.67 30.69 16 6487 258 2351324
Aortic arteriosclerosis 64.36 30.69 19 6484 611 2350971
Angina pectoris 64.14 30.69 31 6472 3956 2347626
Lactic acidosis 63.98 30.69 34 6469 5296 2346286
Visual impairment 63.52 30.69 45 6458 11710 2339872
Blood pressure abnormal 63.36 30.69 24 6479 1681 2349901
Coronary artery disease 63.27 30.69 35 6468 5904 2345678
Depression 63.21 30.69 65 6438 28067 2323515
Encephalopathy 63.09 30.69 32 6471 4529 2347053
Supraventricular tachycardia 63.01 30.69 25 6478 1984 2349598
Pain in extremity 62.77 30.69 79 6424 42461 2309121
Hypokalaemia 62.74 30.69 43 6460 10611 2340971
Sinus node dysfunction 62.55 30.69 19 6484 675 2350907
Haemarthrosis 62.29 30.69 17 6486 409 2351173
Anaemia 61.78 30.69 71 6432 34721 2316861
Peripheral arterial occlusive disease 61.21 30.69 18 6485 571 2351011
Product complaint 60.33 30.69 31 6472 4507 2347075
Haemodynamic instability 60.26 30.69 21 6482 1158 2350424
Renal impairment 60.06 30.69 41 6462 10051 2341531
Renal failure 60.06 30.69 51 6452 17298 2334284
Limb malformation 59.90 30.69 13 6490 113 2351469
Adverse drug reaction 59.88 30.69 38 6465 8245 2343337
Blood glucose increased 59.46 30.69 44 6459 12246 2339336
Abdominal pain 59.11 30.69 69 6434 34305 2317277
Hepatic cyst 59.11 30.69 18 6485 645 2350937
Abdominal pain upper 58.79 30.69 56 6447 22044 2329538
Disorientation 58.31 30.69 34 6469 6338 2345244
Optic ischaemic neuropathy 58.12 30.69 15 6488 289 2351293
Body temperature decreased 57.90 30.69 21 6482 1302 2350280
Sleep disorder 57.73 30.69 34 6469 6455 2345127
Weight decreased 57.41 30.69 62 6441 28309 2323273
Tricuspid valve incompetence 56.84 30.69 22 6481 1634 2349948
Oligohydramnios 56.48 30.69 19 6484 941 2350641
Dysarthria 56.01 30.69 33 6470 6269 2345313
Hiatus hernia 55.30 30.69 23 6480 2061 2349521
Drug level increased 55.13 30.69 25 6478 2762 2348820
Patent ductus arteriosus 54.59 30.69 17 6486 657 2350925
Hypertensive crisis 54.36 30.69 24 6479 2489 2349093
Fryns syndrome 54.06 30.69 8 6495 1 2351581
Wound dehiscence 53.88 30.69 17 6486 686 2350896
Electrocardiogram abnormal 53.82 30.69 20 6483 1328 2350254
Peripheral coldness 53.05 30.69 21 6482 1656 2349926
Inflammatory marker increased 52.95 30.69 16 6487 558 2351024
Urticaria 52.58 30.69 55 6448 24206 2327376
Wound 52.47 30.69 24 6479 2704 2348878
Gastrointestinal haemorrhage 52.39 30.69 41 6462 12394 2339188
Electrocardiogram T wave inversion 51.02 30.69 16 6487 633 2350949
Renal dysplasia 50.86 30.69 10 6493 50 2351532
Normal newborn 50.85 30.69 19 6484 1281 2350301
Atrial tachycardia 50.82 30.69 14 6489 349 2351233
Muscle spasms 50.55 30.69 51 6452 21515 2330067
Seizure 50.42 30.69 54 6449 24412 2327170
Tracheo-oesophageal fistula 49.86 30.69 11 6492 104 2351478
Aplastic anaemia 49.68 30.69 17 6486 887 2350695
Faecaloma 49.48 30.69 17 6486 898 2350684
Asthma 49.17 30.69 38 6465 11276 2340306
Blood pressure systolic decreased 48.64 30.69 16 6487 739 2350843
Middle insomnia 48.49 30.69 19 6484 1458 2350124
Urinary tract infection 47.98 30.69 58 6445 29884 2321698
Pruritus 47.95 30.69 70 6433 43270 2308312
Loss of employment 47.70 30.69 11 6492 129 2351453
Erythema 47.45 30.69 53 6450 25106 2326476
Cardiac disorder 47.02 30.69 32 6471 7801 2343781
Microcephaly 46.95 30.69 11 6492 139 2351443
Congenital diaphragmatic hernia 46.65 30.69 9 6494 40 2351542
Oliguria 46.48 30.69 18 6485 1339 2350243
Phaeochromocytoma crisis 46.46 30.69 9 6494 41 2351541
Lethargy 46.18 30.69 33 6470 8697 2342885
Cyanosis 45.96 30.69 23 6480 3162 2348420
Dyspnoea exertional 45.77 30.69 28 6475 5692 2345890
Congenital choroid plexus cyst 45.61 30.69 9 6494 46 2351536
Pallor 45.27 30.69 24 6479 3718 2347864
Joint dislocation 45.25 30.69 18 6485 1438 2350144
Supraventricular extrasystoles 45.02 30.69 15 6488 721 2350861
Agitation neonatal 44.91 30.69 10 6493 99 2351483
Microtia 43.97 30.69 9 6494 57 2351525
Osteopenia 43.54 30.69 19 6484 1916 2349666
Hypersensitivity 43.29 30.69 49 6454 23544 2328038
Renal impairment neonatal 43.28 30.69 7 6496 7 2351575
Congenital nail disorder 43.21 30.69 8 6495 27 2351555
Escherichia infection 43.06 30.69 17 6486 1331 2350251
Gastrointestinal tract mucosal pigmentation 42.98 30.69 8 6495 28 2351554
Cardiomegaly 42.72 30.69 20 6483 2376 2349206
Polyhydramnios 42.68 30.69 12 6491 323 2351259
Embolism venous 42.47 30.69 12 6491 329 2351253
Proteinuria 42.36 30.69 21 6482 2829 2348753
Arteriospasm coronary 42.06 30.69 14 6489 671 2350911
Cleft palate 41.90 30.69 11 6492 227 2351355
Ischaemic stroke 41.70 30.69 22 6481 3375 2348207
Hallucination, visual 41.48 30.69 21 6482 2958 2348624
Postoperative wound infection 41.44 30.69 16 6487 1180 2350402
Pre-eclampsia 41.26 30.69 17 6486 1487 2350095
Balance disorder 40.75 30.69 32 6471 9715 2341867
Intentional self-injury 40.36 30.69 23 6480 4104 2347478
Pulseless electrical activity 40.30 30.69 15 6488 1000 2350582
Extrasystoles 40.25 30.69 15 6488 1004 2350578
Rash 40.11 30.69 77 6426 59481 2292101
Drug-induced liver injury 39.94 30.69 22 6481 3677 2347905
Neonatal respiratory failure 39.60 30.69 8 6495 47 2351535
Groin pain 39.56 30.69 16 6487 1334 2350248
Sinus tachycardia 39.30 30.69 21 6482 3304 2348278
Agitation 39.28 30.69 33 6470 11018 2340564
Purpura senile 39.23 30.69 7 6496 18 2351564
Therapeutic response unexpected 39.07 30.69 22 6481 3837 2347745
Haemoglobin decreased 39.05 30.69 41 6462 18110 2333472
Dry mouth 38.68 30.69 29 6474 8224 2343358
Drug ineffective for unapproved indication 38.66 30.69 20 6483 2946 2348636
Dyspepsia 38.34 30.69 31 6472 9813 2341769
Oesophageal atresia 38.03 30.69 9 6494 119 2351463
Tachypnoea 37.87 30.69 18 6485 2211 2349371
Hypoperfusion 37.79 30.69 10 6493 213 2351369
Alopecia 37.51 30.69 44 6459 21957 2329625
Urinary retention 37.38 30.69 21 6482 3646 2347936
Paraesthesia 37.37 30.69 44 6459 22044 2329538
Brain oedema 37.26 30.69 18 6485 2292 2349290
Reaction to excipient 37.16 30.69 11 6492 357 2351225
Apallic syndrome 36.92 30.69 9 6494 136 2351446
Pulmonary hypoplasia 36.51 30.69 8 6495 73 2351509
Joint swelling 36.19 30.69 38 6465 16781 2334801
Coarctation of the aorta 36.15 30.69 9 6494 149 2351433
Dysmorphism 36.01 30.69 11 6492 398 2351184
Ventricular septal defect 35.94 30.69 13 6490 799 2350783
Electrocardiogram QRS complex prolonged 35.56 30.69 14 6489 1088 2350494
Hypoaesthesia 35.41 30.69 41 6462 20174 2331408
Delirium 35.36 30.69 23 6480 5200 2346382
Blood creatine increased 34.89 30.69 12 6491 636 2350946
Urinary incontinence 34.58 30.69 21 6482 4212 2347370
Miosis 34.13 30.69 14 6489 1210 2350372
Left ventricular hypertrophy 33.80 30.69 12 6491 699 2350883
Weight increased 33.71 30.69 42 6461 22295 2329287
Dry eye 33.28 30.69 20 6483 3936 2347646
Swelling face 33.02 30.69 28 6475 9465 2342117
Eye oedema 32.76 30.69 10 6493 361 2351221
Chronic kidney disease 32.54 30.69 20 6483 4098 2347484
Still's disease 32.39 30.69 8 6495 128 2351454
Peripartum cardiomyopathy 32.24 30.69 7 6496 61 2351521
Gastrooesophageal reflux disease 31.99 30.69 27 6476 9068 2342514
Orthopnoea 31.01 30.69 11 6492 639 2350943
Alveolitis 30.90 30.69 10 6493 438 2351144
Environmental exposure 30.86 30.69 6 6497 28 2351554
Flatulence 30.81 30.69 20 6483 4505 2347077
Myocarditis 30.77 30.69 13 6490 1210 2350372

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3073.82 28.58 863 5345 15449 1725124
Bradycardia 2933.92 28.58 760 5448 9774 1730799
Hypotension 2026.31 28.58 726 5482 28928 1711645
Toxicity to various agents 1498.27 28.58 581 5627 28560 1712013
Syncope 1356.49 28.58 449 5759 13720 1726853
Dizziness 1232.83 28.58 530 5678 33831 1706742
Cardiac arrest 600.13 28.58 256 5952 15674 1724899
Product prescribing error 563.50 28.58 153 6055 2257 1738316
Dyspnoea 552.60 28.58 357 5851 51702 1688871
Fall 492.00 28.58 264 5944 26950 1713623
Intentional overdose 428.65 28.58 164 6044 7506 1733067
Atrial fibrillation 415.17 28.58 195 6013 14916 1725657
Overdose 375.73 28.58 188 6020 16513 1724060
Heart rate decreased 343.86 28.58 108 6100 2701 1737872
Sinus bradycardia 312.17 28.58 92 6116 1841 1738732
Hyperkalaemia 303.14 28.58 132 6076 8415 1732158
Hypertension 288.30 28.58 166 6042 19282 1721291
Asthenia 276.02 28.58 200 6008 34470 1706103
Fatigue 272.70 28.58 232 5976 50549 1690024
Foetal exposure during pregnancy 264.46 28.58 110 6098 6249 1734324
Orthostatic hypotension 256.46 28.58 91 6117 3340 1737233
Suicide attempt 242.22 28.58 108 6100 7273 1733300
Drug hypersensitivity 228.89 28.58 131 6077 15004 1725569
Drug interaction 221.53 28.58 161 6047 27797 1712776
Acute kidney injury 208.52 28.58 170 6038 34774 1705799
Atrioventricular block 207.10 28.58 62 6146 1309 1739264
Presyncope 207.05 28.58 73 6135 2625 1737948
Drug ineffective 205.64 28.58 220 5988 63581 1676992
Atrioventricular block complete 190.08 28.58 59 6149 1412 1739161
Blood pressure increased 189.53 28.58 103 6105 10650 1729923
Intentional product misuse 183.30 28.58 89 6119 7269 1733304
Metabolic acidosis 173.77 28.58 78 6130 5324 1735249
Chest pain 172.02 28.58 121 6087 19793 1720780
Palpitations 171.46 28.58 83 6125 6731 1733842
Atrial septal defect 160.97 28.58 51 6157 1307 1739266
Cardio-respiratory arrest 160.88 28.58 88 6120 9205 1731368
Arrhythmia 159.59 28.58 76 6132 5940 1734633
Shock 159.54 28.58 68 6140 4093 1736480
Premature baby 157.13 28.58 61 6147 2881 1737692
Nausea 154.86 28.58 171 6037 51025 1689548
Hypoglycaemia 154.68 28.58 83 6125 8355 1732218
Ventricular tachycardia 152.02 28.58 64 6144 3734 1736839
Cardiac failure 148.52 28.58 93 6115 12509 1728064
Medication error 147.80 28.58 67 6141 4676 1735897
General physical health deterioration 147.58 28.58 94 6114 13024 1727549
Acute lung injury 147.43 28.58 32 6176 165 1740408
Condition aggravated 145.36 28.58 112 6096 21038 1719535
Blood pressure decreased 139.53 28.58 75 6133 7571 1733002
Exposure via ingestion 139.36 28.58 39 6169 641 1739932
Respiratory arrest 137.49 28.58 68 6140 5771 1734802
Poisoning 136.98 28.58 53 6155 2479 1738094
Unresponsive to stimuli 136.71 28.58 63 6145 4566 1736007
Blood pressure systolic increased 134.07 28.58 47 6161 1658 1738915
Actinic keratosis 126.64 28.58 35 6173 548 1740025
Cough 121.77 28.58 97 6111 19100 1721473
Wound 120.69 28.58 43 6165 1591 1738982
Drug abuse 119.96 28.58 84 6124 13605 1726968
Chest discomfort 117.44 28.58 66 6142 7265 1733308
Somnolence 115.70 28.58 89 6119 16650 1723923
Cardiogenic shock 113.94 28.58 46 6162 2408 1738165
Hyperhidrosis 112.61 28.58 78 6130 12410 1728163
Death 112.43 28.58 193 6015 87250 1653323
Contraindicated product administered 110.44 28.58 39 6169 1405 1739168
Ventricular fibrillation 108.78 28.58 46 6162 2710 1737863
Patent ductus arteriosus 108.12 28.58 32 6176 647 1739926
Renal failure 107.82 28.58 92 6116 19925 1720648
Atrioventricular block first degree 106.15 28.58 34 6174 902 1739671
Oedema peripheral 103.78 28.58 81 6127 15469 1725104
Headache 102.21 28.58 114 6094 34262 1706311
Body temperature decreased 101.41 28.58 34 6174 1045 1739528
Heart rate irregular 100.77 28.58 38 6170 1654 1738919
Inappropriate schedule of product administration 100.45 28.58 60 6148 7399 1733174
Dyspnoea exertional 99.53 28.58 49 6159 4112 1736461
Dehydration 98.85 28.58 83 6125 17575 1722998
Ejection fraction decreased 97.10 28.58 40 6168 2205 1738368
Tachycardia 95.75 28.58 71 6137 12557 1728016
Small for dates baby 94.28 28.58 28 6180 573 1740000
Depressed level of consciousness 93.93 28.58 55 6153 6537 1734036
Blood pressure inadequately controlled 93.73 28.58 28 6180 585 1739988
Angina pectoris 93.67 28.58 50 6158 4968 1735605
Circulatory collapse 92.49 28.58 44 6164 3423 1737150
Heart rate increased 91.92 28.58 54 6154 6456 1734117
Off label use 88.36 28.58 112 6096 38459 1702114
Low birth weight baby 87.53 28.58 29 6179 858 1739715
Electrocardiogram QRS complex prolonged 87.26 28.58 28 6180 747 1739826
Hypospadias 86.46 28.58 26 6182 556 1740017
Nodal rhythm 85.78 28.58 23 6185 319 1740254
Diarrhoea 84.03 28.58 130 6078 53722 1686851
Coma 83.95 28.58 53 6155 7209 1733364
Loss of consciousness 83.38 28.58 70 6138 14805 1725768
Confusional state 81.78 28.58 81 6127 21197 1719376
Speech disorder 81.19 28.58 44 6164 4504 1736069
Blood pressure diastolic decreased 79.97 28.58 26 6182 724 1739849
Sinus arrest 79.72 28.58 22 6186 342 1740231
Myocardial infarction 78.76 28.58 89 6119 27085 1713488
Mental status changes 76.95 28.58 47 6161 6028 1734545
Anxiety 76.74 28.58 68 6140 15459 1725114
Lethargy 74.57 28.58 49 6159 7135 1733438
Hyperlipidaemia 74.20 28.58 33 6175 2196 1738377
Sinus node dysfunction 73.75 28.58 24 6184 670 1739903
Lactic acidosis 73.59 28.58 43 6165 5086 1735487
Malaise 72.67 28.58 89 6119 29476 1711097
Hypokalaemia 72.37 28.58 46 6162 6328 1734245
Abdominal pain 72.02 28.58 76 6132 21414 1719159
Product substitution issue 70.62 28.58 36 6172 3250 1737323
Electrocardiogram ST segment elevation 70.50 28.58 25 6183 911 1739662
Vomiting 70.46 28.58 100 6108 38215 1702358
Gait disturbance 69.70 28.58 59 6149 12611 1727962
Pain 68.36 28.58 82 6126 26575 1713998
Erectile dysfunction 67.96 28.58 39 6169 4458 1736115
Atrioventricular block second degree 67.68 28.58 22 6186 612 1739961
Dysarthria 67.40 28.58 41 6167 5218 1735355
Oesophageal obstruction 67.17 28.58 15 6193 90 1740483
Bezoar 66.89 28.58 16 6192 135 1740438
Blood creatinine increased 64.80 28.58 59 6149 13887 1726686
Sinus tachycardia 64.07 28.58 31 6177 2501 1738072
Bowen's disease 64.06 28.58 18 6190 300 1740273
Hepatotoxicity 64.00 28.58 33 6175 3051 1737522
Pulmonary oedema 63.71 28.58 43 6165 6543 1734030
Bundle branch block right 63.16 28.58 25 6183 1240 1739333
Pain in extremity 63.07 28.58 66 6142 18406 1722167
Nodal arrhythmia 62.03 28.58 16 6192 189 1740384
Basal cell carcinoma 61.62 28.58 30 6178 2453 1738120
Fracture 59.82 28.58 23 6185 1055 1739518
Blood glucose increased 59.67 28.58 50 6158 10534 1730039
Drug intolerance 59.64 28.58 40 6168 6022 1734551
Macrophages increased 58.32 28.58 10 6198 8 1740565
Cardiotoxicity 58.15 28.58 21 6187 807 1739766
Large for dates baby 57.82 28.58 14 6194 125 1740448
Pulseless electrical activity 57.45 28.58 22 6186 998 1739575
Atrial flutter 55.94 28.58 26 6182 1916 1738657
Acidosis 55.78 28.58 24 6184 1473 1739100
Electrocardiogram QT prolonged 55.54 28.58 37 6171 5508 1735065
Carcinoma in situ of skin 54.21 28.58 11 6197 38 1740535
Therapeutic drug monitoring analysis not performed 53.80 28.58 9 6199 5 1740568
Brain injury 53.67 28.58 21 6187 1010 1739563
Apnoea 53.24 28.58 23 6185 1426 1739147
Renal impairment 53.13 28.58 50 6158 12264 1728309
Vasoplegia syndrome 52.62 28.58 14 6194 188 1740385
Skin ulcer 52.62 28.58 28 6180 2760 1737813
Seizure 52.55 28.58 63 6145 20378 1720195
Product monitoring error 52.14 28.58 12 6196 84 1740489
Blood pressure fluctuation 52.08 28.58 22 6186 1290 1739283
Ventricular septal defect 51.91 28.58 19 6189 759 1739814
Precancerous skin lesion 51.75 28.58 13 6195 137 1740436
Facial asymmetry 51.63 28.58 11 6197 51 1740522
Tachypnoea 51.15 28.58 26 6182 2332 1738241
Bradycardia neonatal 51.07 28.58 14 6194 212 1740361
Muscular weakness 50.82 28.58 45 6163 10204 1730369
Abdominal distension 50.51 28.58 37 6171 6407 1734166
Poisoning deliberate 50.44 28.58 19 6189 823 1739750
Left ventricular hypertrophy 50.23 28.58 19 6189 833 1739740
Supraventricular tachycardia 50.20 28.58 23 6185 1640 1738933
Substance-induced psychotic disorder 48.25 28.58 14 6194 263 1740310
Bradyarrhythmia 47.96 28.58 15 6193 367 1740206
Pulse absent 47.20 28.58 19 6189 985 1739588
Ventricular extrasystoles 46.86 28.58 23 6185 1913 1738660
Hypoglycaemia neonatal 46.52 28.58 14 6194 300 1740273
Chronic obstructive pulmonary disease 46.25 28.58 34 6174 5919 1734654
Hepatic ischaemia 45.67 28.58 10 6198 54 1740519
Acute coronary syndrome 45.42 28.58 24 6184 2331 1738242
Vomiting projectile 45.11 28.58 12 6196 161 1740412
Coronary artery stenosis 45.01 28.58 21 6187 1561 1739012
Blood ethanol increased 44.63 28.58 10 6198 61 1740512
Shone complex 44.03 28.58 8 6200 12 1740561
Feeling abnormal 43.74 28.58 43 6165 11123 1729450
Chronotropic incompetence 43.64 28.58 8 6200 13 1740560
Aorta hypoplasia 43.51 28.58 9 6199 35 1740538
Diplopia 43.46 28.58 24 6184 2546 1738027
Blood sodium decreased 43.08 28.58 23 6185 2281 1738292
Heart rate abnormal 42.91 28.58 13 6195 285 1740288
Stress 42.84 28.58 24 6184 2617 1737956
Weight decreased 42.64 28.58 60 6148 22693 1717880
Balance disorder 42.48 28.58 32 6176 5780 1734793
Pulmonary congestion 42.37 28.58 21 6187 1784 1738789
International normalised ratio increased 42.26 28.58 37 6171 8262 1732311
Haemodynamic instability 41.96 28.58 19 6189 1318 1739255
Erythema 41.92 28.58 47 6161 14141 1726432
Supravalvular aortic stenosis 41.77 28.58 7 6201 4 1740569
Incorrect dose administered 41.73 28.58 35 6173 7374 1733199
Maternal drugs affecting foetus 41.10 28.58 18 6190 1153 1739420
Cardiac failure congestive 40.77 28.58 48 6160 15222 1725351
Vertigo 40.73 28.58 28 6180 4385 1736188
Needle issue 40.72 28.58 15 6193 610 1739963
Systolic anterior motion of mitral valve 40.61 28.58 7 6201 6 1740567
Coronary artery disease 40.59 28.58 39 6169 9807 1730766
Depression 40.58 28.58 50 6158 16619 1723954
Agitation 40.49 28.58 41 6167 10985 1729588
Scratch 40.31 28.58 14 6194 479 1740094
Pruritus 40.24 28.58 59 6149 23163 1717410
Feeling hot 40.10 28.58 24 6184 2963 1737610
Hyponatraemia 39.68 28.58 37 6171 8963 1731610
Drug withdrawal convulsions 39.40 28.58 12 6196 268 1740305
Drug level increased 39.07 28.58 23 6185 2754 1737819
Coagulopathy 39.04 28.58 23 6185 2758 1737815
Mydriasis 38.98 28.58 18 6190 1306 1739267
Restlessness 38.90 28.58 27 6181 4294 1736279
Orthostatic intolerance 38.10 28.58 10 6198 127 1740446
Disorientation 37.52 28.58 29 6179 5440 1735133
Gait inability 37.48 28.58 24 6184 3339 1737234
Intentional self-injury 37.24 28.58 22 6186 2651 1737922
Epistaxis 36.33 28.58 34 6174 8272 1732301
Blood ketone body increased 36.07 28.58 9 6199 92 1740481
Torsade de pointes 35.89 28.58 17 6191 1307 1739266
Foetal growth restriction 35.84 28.58 14 6194 670 1739903
Sleep disorder 35.67 28.58 25 6183 4038 1736535
Implant site extravasation 35.45 28.58 10 6198 169 1740404
Diabetic foetopathy 35.24 28.58 7 6201 21 1740552
Mitral valve incompetence 35.22 28.58 19 6189 1923 1738650
Ventricular hypokinesia 35.20 28.58 14 6194 703 1739870
Cardiomegaly 34.60 28.58 20 6188 2314 1738259
Arterial intramural haematoma 34.36 28.58 6 6202 6 1740567
Kounis syndrome 34.15 28.58 12 6196 425 1740148
Urinary tract infection 34.11 28.58 36 6172 10117 1730456
Serotonin syndrome 33.83 28.58 21 6187 2767 1737806
Onychomycosis 33.73 28.58 11 6197 309 1740264
Hypertensive crisis 33.58 28.58 17 6191 1510 1739063
Hot flush 33.14 28.58 20 6188 2505 1738068
Congenital cystic lung 33.11 28.58 7 6201 31 1740542
Respiratory failure 32.89 28.58 42 6166 14463 1726110
Acute respiratory failure 32.80 28.58 21 6187 2919 1737654
Hepatic steatosis 32.72 28.58 20 6188 2564 1738009
Cardiac disorder 32.71 28.58 31 6177 7660 1732913
Weight increased 32.48 28.58 37 6171 11320 1729253
Treatment noncompliance 32.28 28.58 26 6182 5175 1735398
Myalgia 31.88 28.58 43 6165 15615 1724958
Diabetes mellitus 31.61 28.58 29 6179 6879 1733694
Coronary artery occlusion 31.44 28.58 18 6190 2045 1738528
Congenital muscle absence 31.19 28.58 5 6203 1 1740572
Congenital vas deferens absence 31.19 28.58 5 6203 1 1740572
Hypoxia 31.18 28.58 27 6181 5936 1734637
Electrocardiogram abnormal 31.13 28.58 15 6193 1198 1739375
Musculoskeletal pain 30.72 28.58 25 6183 5049 1735524
Hypertensive emergency 30.34 28.58 9 6199 183 1740390
Product administration error 30.27 28.58 20 6188 2933 1737640
Congenital heart valve disorder 30.21 28.58 6 6202 18 1740555
Hydrops foetalis 30.16 28.58 7 6201 51 1740522
Arthralgia 30.16 28.58 52 6156 23392 1717181
Caesarean section 30.16 28.58 12 6196 603 1739970
Therapy non-responder 30.03 28.58 27 6181 6239 1734334
Bundle branch block left 29.96 28.58 13 6195 814 1739759
Wound dehiscence 29.95 28.58 12 6196 614 1739959
Haemorrhage 29.77 28.58 33 6175 9796 1730777
Dizziness postural 29.62 28.58 13 6195 837 1739736
Body temperature increased 29.57 28.58 19 6189 2658 1737915
Prostatomegaly 29.11 28.58 12 6196 661 1739912
Insomnia 29.11 28.58 42 6166 16234 1724339
Haemoglobin decreased 28.93 28.58 43 6165 17071 1723502
Blood pressure systolic decreased 28.76 28.58 12 6196 682 1739891
Product quality issue 28.70 28.58 26 6182 6067 1734506
Alcohol poisoning 28.67 28.58 11 6197 501 1740072
Cardiac flutter 28.65 28.58 10 6198 347 1740226

Pharmacologic Action:

SourceCodeDescription
ATC C07AB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07BB52 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07CB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07FB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
MeSH PA D018663 Adrenergic Agents
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
CHEBI has role CHEBI:35530 beta-adrenergic antagonist
CHEBI has role CHEBI:35674 antihypertensive agent
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013565 Sympatholytics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Angina pectoris indication 194828000
Acute coronary syndrome indication 394659003
Myocardial Reinfarction Prevention indication
Supraventricular tachycardia off-label use 6456007
Ventricular tachycardia off-label use 25569003
Atrial fibrillation off-label use 49436004 DOID:0060224
Multifocal atrial tachycardia off-label use 49982000
Paroxysmal supraventricular tachycardia off-label use 67198005
Thyrotoxicosis off-label use 90739004 DOID:7997
Paroxysmal atrial tachycardia off-label use 195069001
Ectopic atrial tachycardia off-label use 233892002
Mitral valve prolapse off-label use 409712001
Diastolic heart failure off-label use 418304008 DOID:9775
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Migraine Prevention off-label use
Pheochromocytoma Adjunct Therapy off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Myasthenia gravis contraindication 91637004 DOID:437
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Azotemia contraindication 445009001
Acute exacerbation of asthma contraindication 708038006
First Degree Atrioventricular Heart Block contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.60 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.30 WOMBAT-PK
Adrenergic receptor beta GPCR IC50 6.30 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.79 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.83 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL

External reference:

IDSource
C0350132 UMLSCUI
D00601 KEGG_DRUG
7092007 SNOMEDCT_US
4019836 VANDF
6918 RXNORM
372826007 SNOMEDCT_US
d00134 MMSL
003627 NDDF
CHEBI:6904 CHEBI
CHEMBL13 ChEMBL_ID
DB00264 DRUGBANK_ID
CHEMBL1200337 ChEMBL_ID
GEB06NHM23 UNII
3471 INN_ID
80274-67-5 SECONDARY_CAS_RN
4171 PUBCHEM_CID
D008790 MESH_DESCRIPTOR_UI
CHEMBL2062335 ChEMBL_ID
CHEMBL2356097 ChEMBL_ID
CHEMBL3989566 ChEMBL_ID
553 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9660 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9873 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0018 TABLET, FILM COATED 25 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0032 TABLET, FILM COATED 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0047 TABLET, FILM COATED 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0424 TABLET 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0434 TABLET 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0445 TABLET 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4593 TABLET, FILM COATED 37.50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4594 TABLET, FILM COATED 75 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1778 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-2285 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0591-0462 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0591-0463 TABLET, FILM COATED 100 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-3552 TABLET 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-3553 TABLET 100 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-6547 TABLET, FILM COATED 25 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8016 TABLET, FILM COATED 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8017 TABLET, FILM COATED 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8322 TABLET, FILM COATED 25 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6340 TABLET 25 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6341 TABLET 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6342 TABLET 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-124 TABLET 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-263 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-298 TABLET, FILM COATED 25 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-553 TABLET 100 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-879 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 12634-771 TABLET, FILM COATED 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 13107-062 TABLET, FILM COATED 25 mg ORAL ANDA 12 sections