Stem definition | Drug id | CAS RN |
---|---|---|
beta-adrenoreceptor antagonists | 1786 | 51384-51-1 |
Dose | Unit | Route |
---|---|---|
0.15 | g | O |
0.15 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 1000 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 24.95 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 38 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 13 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.88 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 3.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 7, 1978 | FDA | US PHARMS HOLDINGS I |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myocardial infarction | 1061.15 | 9.89 | 1837 | 281416 | 87190 | 50234681 |
Cardiac failure congestive | 820.64 | 9.89 | 1595 | 281658 | 82787 | 50239084 |
Atrial fibrillation | 747.46 | 9.89 | 1715 | 281538 | 100030 | 50221841 |
Drug ineffective | 608.24 | 9.89 | 2450 | 280803 | 816883 | 49504988 |
Pemphigus | 601.33 | 9.89 | 15 | 283238 | 120151 | 50201720 |
Coronary artery disease | 570.61 | 9.89 | 766 | 282487 | 28960 | 50292911 |
Synovitis | 520.56 | 9.89 | 47 | 283206 | 123818 | 50198053 |
Systemic lupus erythematosus | 516.03 | 9.89 | 84 | 283169 | 140538 | 50181333 |
Bradycardia | 515.46 | 9.89 | 1124 | 282129 | 63302 | 50258569 |
Hand deformity | 499.44 | 9.89 | 13 | 283240 | 100186 | 50221685 |
Contraindicated product administered | 493.85 | 9.89 | 114 | 283139 | 148844 | 50173027 |
Glossodynia | 452.03 | 9.89 | 57 | 283196 | 115512 | 50206359 |
Drug intolerance | 415.51 | 9.89 | 369 | 282884 | 218735 | 50103136 |
Acute myocardial infarction | 411.36 | 9.89 | 651 | 282602 | 28622 | 50293249 |
Anti-cyclic citrullinated peptide antibody positive | 377.73 | 9.89 | 3 | 283250 | 70584 | 50251287 |
Completed suicide | 365.58 | 9.89 | 1585 | 281668 | 130304 | 50191567 |
Treatment failure | 364.33 | 9.89 | 157 | 283096 | 137480 | 50184391 |
Infusion related reaction | 353.26 | 9.89 | 260 | 282993 | 169297 | 50152574 |
Arthropathy | 347.68 | 9.89 | 228 | 283025 | 157678 | 50164193 |
Pericarditis | 327.48 | 9.89 | 31 | 283222 | 78658 | 50243213 |
Cerebrovascular accident | 317.25 | 9.89 | 1207 | 282046 | 93473 | 50228398 |
Joint swelling | 311.92 | 9.89 | 560 | 282693 | 244726 | 50077145 |
Rheumatoid arthritis | 293.61 | 9.89 | 424 | 282829 | 202126 | 50119745 |
Hypotension | 289.78 | 9.89 | 2281 | 280972 | 233188 | 50088683 |
Therapeutic product effect decreased | 278.96 | 9.89 | 212 | 283041 | 135838 | 50186033 |
Lower respiratory tract infection | 272.67 | 9.89 | 96 | 283157 | 95105 | 50226766 |
Rheumatoid factor positive | 254.10 | 9.89 | 5 | 283248 | 49854 | 50272017 |
Swelling | 253.12 | 9.89 | 461 | 282792 | 200411 | 50121460 |
Maternal exposure during pregnancy | 247.06 | 9.89 | 319 | 282934 | 159459 | 50162412 |
Hypersensitivity | 243.42 | 9.89 | 526 | 282727 | 214635 | 50107236 |
Off label use | 241.31 | 9.89 | 1611 | 281642 | 472815 | 49849056 |
Product prescribing error | 235.67 | 9.89 | 422 | 282831 | 20539 | 50301332 |
Duodenal ulcer perforation | 234.79 | 9.89 | 4 | 283249 | 45607 | 50276264 |
Dizziness | 217.98 | 9.89 | 2924 | 280329 | 343445 | 49978426 |
Helicobacter infection | 211.03 | 9.89 | 18 | 283235 | 49684 | 50272187 |
Syncope | 208.85 | 9.89 | 1132 | 282121 | 101870 | 50220001 |
Wound | 198.12 | 9.89 | 180 | 283073 | 105614 | 50216257 |
Pain | 186.49 | 9.89 | 2210 | 281043 | 576693 | 49745178 |
Hepatic enzyme increased | 179.53 | 9.89 | 308 | 282945 | 137072 | 50184799 |
Rash | 177.34 | 9.89 | 1581 | 281672 | 435890 | 49885981 |
Folliculitis | 175.70 | 9.89 | 11 | 283242 | 39214 | 50282657 |
Cardiac disorder | 174.73 | 9.89 | 584 | 282669 | 42395 | 50279476 |
Alopecia | 173.82 | 9.89 | 743 | 282510 | 244304 | 50077567 |
Muscle injury | 173.74 | 9.89 | 8 | 283245 | 37103 | 50284768 |
Abdominal discomfort | 166.34 | 9.89 | 699 | 282554 | 230942 | 50090929 |
Coronary artery bypass | 165.58 | 9.89 | 122 | 283131 | 2171 | 50319700 |
Fall | 162.71 | 9.89 | 2705 | 280548 | 332227 | 49989644 |
Gastrointestinal haemorrhage | 161.76 | 9.89 | 825 | 282428 | 72496 | 50249375 |
Product use issue | 157.91 | 9.89 | 379 | 282874 | 149096 | 50172775 |
Discomfort | 157.74 | 9.89 | 226 | 283027 | 108154 | 50213717 |
Palpitations | 154.23 | 9.89 | 981 | 282272 | 93525 | 50228346 |
Cardiogenic shock | 147.91 | 9.89 | 292 | 282961 | 15307 | 50306564 |
Angina pectoris | 147.24 | 9.89 | 399 | 282854 | 25789 | 50296082 |
Product monitoring error | 139.27 | 9.89 | 119 | 283134 | 2645 | 50319226 |
Dyspnoea | 137.22 | 9.89 | 4021 | 279232 | 543587 | 49778284 |
Pyrexia | 133.29 | 9.89 | 1423 | 281830 | 378780 | 49943091 |
Arthralgia | 131.81 | 9.89 | 1699 | 281554 | 437003 | 49884868 |
Coronary arterial stent insertion | 129.86 | 9.89 | 112 | 283141 | 2522 | 50319349 |
Sinus bradycardia | 125.26 | 9.89 | 247 | 283006 | 12936 | 50308935 |
Angina unstable | 118.36 | 9.89 | 166 | 283087 | 6540 | 50315331 |
International normalised ratio increased | 118.12 | 9.89 | 517 | 282736 | 42635 | 50279236 |
Haematochezia | 117.02 | 9.89 | 488 | 282765 | 39394 | 50282477 |
Abortion spontaneous | 116.38 | 9.89 | 44 | 283209 | 41728 | 50280143 |
Arrhythmia | 116.34 | 9.89 | 429 | 282824 | 32703 | 50289168 |
Irritable bowel syndrome | 116.22 | 9.89 | 72 | 283181 | 51369 | 50270502 |
Sleep disorder due to general medical condition, insomnia type | 114.77 | 9.89 | 19 | 283234 | 31428 | 50290443 |
Exposure during pregnancy | 112.44 | 9.89 | 327 | 282926 | 120688 | 50201183 |
General physical health deterioration | 112.04 | 9.89 | 1255 | 281998 | 141179 | 50180692 |
Infection | 109.13 | 9.89 | 547 | 282706 | 172407 | 50149464 |
Drug hypersensitivity | 107.29 | 9.89 | 894 | 282359 | 250116 | 50071755 |
C-reactive protein abnormal | 105.60 | 9.89 | 15 | 283238 | 27794 | 50294077 |
Renal failure | 105.57 | 9.89 | 985 | 282268 | 105648 | 50216223 |
Cardiac failure | 105.29 | 9.89 | 758 | 282495 | 75282 | 50246589 |
Dehydration | 104.80 | 9.89 | 1309 | 281944 | 151140 | 50170731 |
Asthenia | 101.96 | 9.89 | 2420 | 280833 | 316622 | 50005249 |
Death | 101.85 | 9.89 | 2461 | 280792 | 322918 | 49998953 |
Cardiac arrest | 101.84 | 9.89 | 809 | 282444 | 82842 | 50239029 |
Oedema peripheral | 97.55 | 9.89 | 1330 | 281923 | 156631 | 50165240 |
Pregnancy | 95.24 | 9.89 | 24 | 283229 | 29553 | 50292318 |
Febrile neutropenia | 92.85 | 9.89 | 261 | 282992 | 97406 | 50224465 |
Sinusitis | 92.00 | 9.89 | 568 | 282685 | 169990 | 50151881 |
Ventricular tachycardia | 88.88 | 9.89 | 241 | 283012 | 15580 | 50306291 |
Blister | 87.46 | 9.89 | 220 | 283033 | 85198 | 50236673 |
Blood pressure increased | 85.50 | 9.89 | 1129 | 282124 | 132003 | 50189868 |
Drug interaction | 82.73 | 9.89 | 1573 | 281680 | 198048 | 50123823 |
Blood loss anaemia | 81.60 | 9.89 | 156 | 283097 | 7983 | 50313888 |
Musculoskeletal stiffness | 81.21 | 9.89 | 406 | 282847 | 128075 | 50193796 |
Pulmonary oedema | 81.02 | 9.89 | 510 | 282743 | 48428 | 50273443 |
Chest pain | 80.34 | 9.89 | 1414 | 281839 | 175468 | 50146403 |
Blood pressure inadequately controlled | 79.66 | 9.89 | 110 | 283143 | 4270 | 50317601 |
Acute kidney injury | 79.32 | 9.89 | 1751 | 281502 | 226307 | 50095564 |
Gastrointestinal disorder | 78.73 | 9.89 | 268 | 282985 | 94188 | 50227683 |
Ill-defined disorder | 78.47 | 9.89 | 115 | 283138 | 54539 | 50267332 |
Hypertensive crisis | 76.54 | 9.89 | 203 | 283050 | 12951 | 50308920 |
Hip arthroplasty | 73.86 | 9.89 | 39 | 283214 | 30390 | 50291481 |
Suspected suicide | 73.66 | 9.89 | 118 | 283135 | 5239 | 50316632 |
Neutropenia | 72.58 | 9.89 | 507 | 282746 | 147458 | 50174413 |
Haemoglobin decreased | 72.02 | 9.89 | 1055 | 282198 | 126161 | 50195710 |
Device expulsion | 71.36 | 9.89 | 36 | 283217 | 28786 | 50293085 |
Medication error | 69.22 | 9.89 | 391 | 282862 | 35713 | 50286158 |
Labelled drug-drug interaction medication error | 68.54 | 9.89 | 169 | 283084 | 10308 | 50311563 |
Drug abuse | 66.15 | 9.89 | 148 | 283105 | 59698 | 50262173 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 65.98 | 9.89 | 73 | 283180 | 2249 | 50319622 |
Plasma cell myeloma | 65.96 | 9.89 | 348 | 282905 | 30974 | 50290897 |
Nodal rhythm | 65.42 | 9.89 | 61 | 283192 | 1526 | 50320345 |
Anaemia | 65.40 | 9.89 | 1863 | 281390 | 250593 | 50071278 |
Product substitution issue | 65.29 | 9.89 | 200 | 283053 | 13857 | 50308014 |
C-reactive protein increased | 64.39 | 9.89 | 176 | 283077 | 66298 | 50255573 |
Blood creatinine increased | 63.94 | 9.89 | 680 | 282573 | 75480 | 50246391 |
Interstitial lung disease | 62.53 | 9.89 | 127 | 283126 | 53049 | 50268822 |
Coronary artery occlusion | 62.33 | 9.89 | 133 | 283120 | 7370 | 50314501 |
Drug resistance | 60.01 | 9.89 | 16 | 283237 | 18973 | 50302898 |
Product use in unapproved indication | 59.70 | 9.89 | 391 | 282862 | 115428 | 50206443 |
Red blood cell sedimentation rate increased | 58.75 | 9.89 | 47 | 283206 | 29369 | 50292502 |
Toxicity to various agents | 58.06 | 9.89 | 1579 | 281674 | 210920 | 50110951 |
Ventricular fibrillation | 57.47 | 9.89 | 159 | 283094 | 10400 | 50311471 |
Impaired healing | 57.47 | 9.89 | 199 | 283054 | 69587 | 50252284 |
Ejection fraction | 57.09 | 9.89 | 50 | 283203 | 1150 | 50320721 |
Unresponsive to stimuli | 56.39 | 9.89 | 328 | 282925 | 30281 | 50291590 |
Sensitisation | 56.14 | 9.89 | 56 | 283197 | 1526 | 50320345 |
Myocardial ischaemia | 55.60 | 9.89 | 167 | 283086 | 11446 | 50310425 |
Diarrhoea | 55.18 | 9.89 | 3911 | 279342 | 584565 | 49737306 |
Condition aggravated | 54.96 | 9.89 | 1255 | 281998 | 295803 | 50026068 |
Hypertensive emergency | 54.87 | 9.89 | 55 | 283198 | 1508 | 50320363 |
Chronic kidney disease | 54.18 | 9.89 | 395 | 282858 | 39376 | 50282495 |
Atrial flutter | 53.81 | 9.89 | 138 | 283115 | 8625 | 50313246 |
Inflammation | 53.40 | 9.89 | 153 | 283100 | 56759 | 50265112 |
Pulmonary renal syndrome | 52.71 | 9.89 | 31 | 283222 | 369 | 50321502 |
Therapeutic drug monitoring analysis not performed | 52.01 | 9.89 | 38 | 283215 | 667 | 50321204 |
Suicidal ideation | 51.89 | 9.89 | 149 | 283104 | 55236 | 50266635 |
Atrioventricular block | 51.72 | 9.89 | 113 | 283140 | 6365 | 50315506 |
Mental status changes | 51.00 | 9.89 | 363 | 282890 | 35909 | 50285962 |
Product administration error | 50.87 | 9.89 | 232 | 283021 | 19467 | 50302404 |
BRASH syndrome | 49.25 | 9.89 | 24 | 283229 | 189 | 50321682 |
Transient ischaemic attack | 49.22 | 9.89 | 329 | 282924 | 31881 | 50289990 |
Orthostatic intolerance | 49.06 | 9.89 | 42 | 283211 | 936 | 50320935 |
Drug reaction with eosinophilia and systemic symptoms | 48.97 | 9.89 | 52 | 283201 | 28372 | 50293499 |
Presyncope | 48.33 | 9.89 | 265 | 282988 | 23933 | 50297938 |
Nasopharyngitis | 48.28 | 9.89 | 774 | 282479 | 192153 | 50129718 |
Lower gastrointestinal haemorrhage | 48.25 | 9.89 | 114 | 283139 | 6765 | 50315106 |
Hyperkalaemia | 46.94 | 9.89 | 443 | 282810 | 47646 | 50274225 |
Lactic acidosis | 46.43 | 9.89 | 333 | 282920 | 33022 | 50288849 |
Pulmonary hypertension | 46.15 | 9.89 | 333 | 282920 | 33084 | 50288787 |
Peripheral arterial occlusive disease | 46.04 | 9.89 | 76 | 283177 | 3461 | 50318410 |
Ischaemic stroke | 45.10 | 9.89 | 193 | 283060 | 15755 | 50306116 |
Bone erosion | 45.09 | 9.89 | 6 | 283247 | 11681 | 50310190 |
Full blood count decreased | 44.82 | 9.89 | 245 | 283008 | 22101 | 50299770 |
Heart rate increased | 43.83 | 9.89 | 641 | 282612 | 76609 | 50245262 |
Atrioventricular block complete | 43.26 | 9.89 | 113 | 283140 | 7142 | 50314729 |
Erythema | 43.04 | 9.89 | 569 | 282684 | 145845 | 50176026 |
Renal impairment | 42.60 | 9.89 | 627 | 282626 | 75034 | 50246837 |
Thrombosis | 41.61 | 9.89 | 487 | 282766 | 55346 | 50266525 |
Migraine | 41.43 | 9.89 | 249 | 283004 | 75031 | 50246840 |
Heart rate irregular | 40.69 | 9.89 | 215 | 283038 | 19145 | 50302726 |
Stomatitis | 40.52 | 9.89 | 367 | 282886 | 100977 | 50220894 |
Hepatic function abnormal | 40.19 | 9.89 | 76 | 283177 | 32605 | 50289266 |
Acute coronary syndrome | 39.53 | 9.89 | 129 | 283124 | 9245 | 50312626 |
Mobility decreased | 39.14 | 9.89 | 274 | 282979 | 79674 | 50242197 |
Nephrogenic systemic fibrosis | 38.69 | 9.89 | 79 | 283174 | 4243 | 50317628 |
Hypertension | 38.57 | 9.89 | 1496 | 281757 | 209707 | 50112164 |
Abortion induced | 38.02 | 9.89 | 4 | 283249 | 9340 | 50312531 |
Deep vein thrombosis | 38.01 | 9.89 | 599 | 282654 | 72705 | 50249166 |
Intentional product use issue | 37.96 | 9.89 | 263 | 282990 | 76655 | 50245216 |
Rheumatoid nodule | 37.91 | 9.89 | 12 | 283241 | 12723 | 50309148 |
Blood pressure decreased | 37.89 | 9.89 | 479 | 282774 | 55430 | 50266441 |
Ventricular extrasystoles | 37.61 | 9.89 | 137 | 283116 | 10379 | 50311492 |
Blood test abnormal | 37.60 | 9.89 | 144 | 283109 | 11175 | 50310696 |
Atrioventricular block first degree | 37.40 | 9.89 | 97 | 283156 | 6104 | 50315767 |
Mitral valve incompetence | 37.39 | 9.89 | 195 | 283058 | 17276 | 50304595 |
Heart rate decreased | 37.02 | 9.89 | 339 | 282914 | 36158 | 50285713 |
Injection site pain | 36.96 | 9.89 | 420 | 282833 | 110604 | 50211267 |
Urticaria | 36.81 | 9.89 | 507 | 282746 | 129054 | 50192817 |
Hyponatraemia | 36.53 | 9.89 | 748 | 282505 | 95391 | 50226480 |
Cerebral haemorrhage | 36.45 | 9.89 | 268 | 282985 | 26784 | 50295087 |
Knee arthroplasty | 36.15 | 9.89 | 93 | 283160 | 35753 | 50286118 |
Decorticate posture | 36.08 | 9.89 | 22 | 283231 | 281 | 50321590 |
Cardiac output decreased | 35.96 | 9.89 | 34 | 283219 | 866 | 50321005 |
Live birth | 35.64 | 9.89 | 24 | 283229 | 16384 | 50305487 |
Coronary artery stenosis | 35.59 | 9.89 | 76 | 283177 | 4213 | 50317658 |
Tachyarrhythmia | 35.53 | 9.89 | 74 | 283179 | 4031 | 50317840 |
Renal injury | 34.97 | 9.89 | 117 | 283136 | 8494 | 50313377 |
Headache | 34.93 | 9.89 | 2404 | 280849 | 504131 | 49817740 |
Myocardial depression | 34.90 | 9.89 | 25 | 283228 | 425 | 50321446 |
Sopor | 34.66 | 9.89 | 36 | 283217 | 19843 | 50302028 |
Drug tolerance decreased | 34.64 | 9.89 | 5 | 283248 | 9155 | 50312716 |
Polycystic ovaries | 34.54 | 9.89 | 55 | 283198 | 2429 | 50319442 |
Vascular graft | 34.44 | 9.89 | 31 | 283222 | 740 | 50321131 |
Congenital hydronephrosis | 34.42 | 9.89 | 24 | 283229 | 390 | 50321481 |
Intestinal malrotation | 34.27 | 9.89 | 23 | 283230 | 350 | 50321521 |
Dyspnoea exertional | 33.48 | 9.89 | 436 | 282817 | 50797 | 50271074 |
Hypomagnesaemia | 33.28 | 9.89 | 233 | 283020 | 22923 | 50298948 |
Supraventricular tachycardia | 33.23 | 9.89 | 151 | 283102 | 12650 | 50309221 |
Hypoglycaemia | 32.95 | 9.89 | 451 | 282802 | 53130 | 50268741 |
Pruritus | 32.90 | 9.89 | 1276 | 281977 | 282292 | 50039579 |
Intentional self-injury | 32.81 | 9.89 | 49 | 283204 | 23063 | 50298808 |
Hip fracture | 32.75 | 9.89 | 253 | 283000 | 25678 | 50296193 |
Congenital aortic valve stenosis | 32.39 | 9.89 | 13 | 283240 | 60 | 50321811 |
Haemophagocytic lymphohistiocytosis | 31.98 | 9.89 | 5 | 283248 | 8628 | 50313243 |
Anaphylactic reaction | 31.78 | 9.89 | 175 | 283078 | 53880 | 50267991 |
Neutropenic sepsis | 31.67 | 9.89 | 20 | 283233 | 14127 | 50307744 |
Drug eruption | 31.65 | 9.89 | 52 | 283201 | 23554 | 50298317 |
Injection site reaction | 31.64 | 9.89 | 158 | 283095 | 49874 | 50271997 |
Acute respiratory failure | 31.59 | 9.89 | 272 | 282981 | 28510 | 50293361 |
Product dose omission issue | 31.42 | 9.89 | 1293 | 281960 | 182545 | 50139326 |
Hepatocellular injury | 31.33 | 9.89 | 61 | 283192 | 25886 | 50295985 |
Gout | 31.05 | 9.89 | 137 | 283116 | 11333 | 50310538 |
Internal haemorrhage | 30.77 | 9.89 | 73 | 283180 | 4344 | 50317527 |
Haematoma | 30.74 | 9.89 | 283 | 282970 | 30227 | 50291644 |
Hypervolaemia | 30.67 | 9.89 | 246 | 283007 | 25253 | 50296618 |
Urinary tract infection | 30.55 | 9.89 | 1540 | 281713 | 222480 | 50099391 |
Heart rate abnormal | 30.03 | 9.89 | 68 | 283185 | 3924 | 50317947 |
Epistaxis | 29.97 | 9.89 | 514 | 282739 | 63440 | 50258431 |
Hypothermia | 29.90 | 9.89 | 140 | 283113 | 11876 | 50309995 |
Pneumocystis jirovecii pneumonia | 29.82 | 9.89 | 23 | 283230 | 14640 | 50307231 |
Torsade de pointes | 29.53 | 9.89 | 138 | 283115 | 11697 | 50310174 |
Listless | 29.30 | 9.89 | 50 | 283203 | 2340 | 50319531 |
Bradyarrhythmia | 29.30 | 9.89 | 44 | 283209 | 1846 | 50320025 |
Bundle branch block left | 29.27 | 9.89 | 89 | 283164 | 6141 | 50315730 |
Cardiovascular disorder | 29.17 | 9.89 | 126 | 283127 | 10328 | 50311543 |
Cardiac failure acute | 29.10 | 9.89 | 107 | 283146 | 8143 | 50313728 |
Loss of employment | 29.09 | 9.89 | 40 | 283213 | 1546 | 50320325 |
Ventricular arrhythmia | 29.05 | 9.89 | 60 | 283193 | 3249 | 50318622 |
Cytomegalovirus infection | 28.62 | 9.89 | 35 | 283218 | 17927 | 50303944 |
Wrong product administered | 28.47 | 9.89 | 80 | 283173 | 5280 | 50316591 |
Blood potassium decreased | 28.30 | 9.89 | 324 | 282929 | 36621 | 50285250 |
Tendonitis | 28.29 | 9.89 | 31 | 283222 | 16674 | 50305197 |
Device capturing issue | 28.22 | 9.89 | 10 | 283243 | 30 | 50321841 |
Skin induration | 28.21 | 9.89 | 55 | 283198 | 2856 | 50319015 |
Angioedema | 27.79 | 9.89 | 328 | 282925 | 37348 | 50284523 |
Renal disorder | 27.65 | 9.89 | 255 | 282998 | 27250 | 50294621 |
Bone marrow failure | 27.60 | 9.89 | 72 | 283181 | 27552 | 50294319 |
Conjoined twins | 27.51 | 9.89 | 18 | 283235 | 262 | 50321609 |
Lymphocyte count decreased | 27.50 | 9.89 | 67 | 283186 | 26240 | 50295631 |
Arteriosclerosis | 27.35 | 9.89 | 112 | 283141 | 8965 | 50312906 |
Cardiac pacemaker insertion | 27.23 | 9.89 | 62 | 283191 | 3591 | 50318280 |
Hiatus hernia | 27.20 | 9.89 | 186 | 283067 | 18158 | 50303713 |
Acute left ventricular failure | 27.20 | 9.89 | 28 | 283225 | 793 | 50321078 |
Panniculitis | 27.18 | 9.89 | 7 | 283246 | 8496 | 50313375 |
Therapeutic product effect incomplete | 27.11 | 9.89 | 355 | 282898 | 91160 | 50230711 |
Blood glucose increased | 27.11 | 9.89 | 555 | 282698 | 70769 | 50251102 |
Type 2 diabetes mellitus | 26.98 | 9.89 | 100 | 283153 | 34275 | 50287596 |
Allergic reaction to excipient | 26.93 | 9.89 | 18 | 283235 | 272 | 50321599 |
Pallor | 26.92 | 9.89 | 222 | 283031 | 22977 | 50298894 |
Cardiomegaly | 26.90 | 9.89 | 167 | 283086 | 15778 | 50306093 |
Body temperature increased | 26.73 | 9.89 | 88 | 283165 | 31253 | 50290618 |
Arterial haemorrhage | 26.67 | 9.89 | 38 | 283215 | 1519 | 50320352 |
Ischaemic cardiomyopathy | 26.56 | 9.89 | 47 | 283206 | 2265 | 50319606 |
Sedation complication | 26.56 | 9.89 | 8 | 283245 | 8758 | 50313113 |
Mucosal inflammation | 26.41 | 9.89 | 125 | 283128 | 40017 | 50281854 |
Therapy non-responder | 26.40 | 9.89 | 172 | 283081 | 50850 | 50271021 |
Nodal arrhythmia | 26.34 | 9.89 | 32 | 283221 | 1092 | 50320779 |
Aortic valve stenosis | 26.18 | 9.89 | 54 | 283199 | 2921 | 50318950 |
Electrocardiogram T wave abnormal | 26.14 | 9.89 | 46 | 283207 | 2207 | 50319664 |
Body height decreased | 26.12 | 9.89 | 109 | 283144 | 8799 | 50313072 |
Blood urea increased | 25.94 | 9.89 | 223 | 283030 | 23362 | 50298509 |
Injection site erythema | 25.92 | 9.89 | 281 | 282972 | 74655 | 50247216 |
Hypertensive heart disease | 25.89 | 9.89 | 46 | 283207 | 2224 | 50319647 |
Acute generalised exanthematous pustulosis | 25.59 | 9.89 | 9 | 283244 | 8929 | 50312942 |
Therapeutic response decreased | 25.58 | 9.89 | 157 | 283096 | 47074 | 50274797 |
Fluid retention | 25.54 | 9.89 | 412 | 282841 | 50237 | 50271634 |
Aortic valve incompetence | 25.51 | 9.89 | 78 | 283175 | 5398 | 50316473 |
Pleural effusion | 25.34 | 9.89 | 616 | 282637 | 80838 | 50241033 |
Dystonia | 25.17 | 9.89 | 18 | 283235 | 11908 | 50309963 |
Body tinea | 25.15 | 9.89 | 34 | 283219 | 1293 | 50320578 |
Nephrectomy | 25.03 | 9.89 | 27 | 283226 | 808 | 50321063 |
Device dislocation | 24.86 | 9.89 | 52 | 283201 | 21494 | 50300377 |
Decreased appetite | 24.52 | 9.89 | 1367 | 281886 | 199556 | 50122315 |
Venous pressure jugular increased | 24.38 | 9.89 | 22 | 283231 | 527 | 50321344 |
Infective pulmonary exacerbation of cystic fibrosis | 24.36 | 9.89 | 7 | 283246 | 7902 | 50313969 |
Electrolyte imbalance | 24.23 | 9.89 | 172 | 283081 | 16997 | 50304874 |
Tachycardia | 24.07 | 9.89 | 730 | 282523 | 99033 | 50222838 |
Heparin-induced thrombocytopenia | 23.89 | 9.89 | 62 | 283191 | 3903 | 50317968 |
Product solubility abnormal | 23.70 | 9.89 | 25 | 283228 | 729 | 50321142 |
Glomerular filtration rate decreased | 23.53 | 9.89 | 128 | 283125 | 11524 | 50310347 |
Hepatotoxicity | 23.53 | 9.89 | 76 | 283177 | 27150 | 50294721 |
Haemarthrosis | 23.53 | 9.89 | 51 | 283202 | 2857 | 50319014 |
Immunodeficiency | 23.51 | 9.89 | 29 | 283224 | 14799 | 50307072 |
Progressive multifocal leukoencephalopathy | 23.26 | 9.89 | 18 | 283235 | 11439 | 50310432 |
Gastrointestinal tract mucosal pigmentation | 23.22 | 9.89 | 22 | 283231 | 562 | 50321309 |
Labile hypertension | 23.16 | 9.89 | 20 | 283233 | 451 | 50321420 |
Asthma | 23.13 | 9.89 | 356 | 282897 | 88981 | 50232890 |
Diverticulum intestinal haemorrhagic | 22.93 | 9.89 | 31 | 283222 | 1179 | 50320692 |
Vitello-intestinal duct remnant | 22.87 | 9.89 | 9 | 283244 | 39 | 50321832 |
Cardiac ablation | 22.79 | 9.89 | 32 | 283221 | 1262 | 50320609 |
Intraventricular haemorrhage | 22.77 | 9.89 | 39 | 283214 | 1831 | 50320040 |
Troponin increased | 22.77 | 9.89 | 98 | 283155 | 8020 | 50313851 |
Coronary artery dissection | 22.66 | 9.89 | 24 | 283229 | 703 | 50321168 |
Rhabdomyolysis | 22.58 | 9.89 | 325 | 282928 | 38702 | 50283169 |
Sudden cardiac death | 22.54 | 9.89 | 40 | 283213 | 1932 | 50319939 |
Hepatitis | 22.46 | 9.89 | 95 | 283158 | 31358 | 50290513 |
Granuloma skin | 22.41 | 9.89 | 3 | 283250 | 5815 | 50316056 |
Lymphopenia | 22.29 | 9.89 | 33 | 283220 | 15588 | 50306283 |
Atrioventricular block second degree | 22.21 | 9.89 | 57 | 283196 | 3564 | 50318307 |
Muscle spasticity | 21.99 | 9.89 | 39 | 283214 | 17145 | 50304726 |
Ageusia | 21.90 | 9.89 | 125 | 283128 | 11458 | 50310413 |
Rhinitis allergic | 21.82 | 9.89 | 89 | 283164 | 7111 | 50314760 |
Myxoedema coma | 21.80 | 9.89 | 18 | 283235 | 381 | 50321490 |
Ventricular hypokinesia | 21.73 | 9.89 | 60 | 283193 | 3920 | 50317951 |
Psoriatic arthropathy | 21.66 | 9.89 | 164 | 283089 | 46868 | 50275003 |
Blue toe syndrome | 21.52 | 9.89 | 18 | 283235 | 388 | 50321483 |
Electrocardiogram abnormal | 21.48 | 9.89 | 92 | 283161 | 7513 | 50314358 |
Gouty arthritis | 21.46 | 9.89 | 20 | 283233 | 500 | 50321371 |
Neutrophil count decreased | 21.43 | 9.89 | 160 | 283093 | 45866 | 50276005 |
Non-cardiogenic pulmonary oedema | 21.42 | 9.89 | 21 | 283232 | 560 | 50321311 |
Subchondral insufficiency fracture | 21.38 | 9.89 | 9 | 283244 | 48 | 50321823 |
Cardiomyopathy | 21.34 | 9.89 | 155 | 283098 | 15431 | 50306440 |
Rash maculo-papular | 21.24 | 9.89 | 77 | 283176 | 26564 | 50295307 |
CD30 expression | 21.23 | 9.89 | 8 | 283245 | 30 | 50321841 |
Cholestasis | 21.20 | 9.89 | 72 | 283181 | 25329 | 50296542 |
Glucose tolerance impaired | 21.19 | 9.89 | 70 | 283183 | 5048 | 50316823 |
Vascular resistance pulmonary decreased | 21.16 | 9.89 | 10 | 283243 | 73 | 50321798 |
Weight increased | 21.14 | 9.89 | 919 | 282334 | 200972 | 50120899 |
Anuria | 21.04 | 9.89 | 121 | 283132 | 11123 | 50310748 |
Congenital bladder anomaly | 20.99 | 9.89 | 13 | 283240 | 171 | 50321700 |
Poisoning deliberate | 20.95 | 9.89 | 9 | 283244 | 7903 | 50313968 |
Bicuspid aortic valve | 20.87 | 9.89 | 11 | 283242 | 104 | 50321767 |
Phaeochromocytoma crisis | 20.87 | 9.89 | 14 | 283239 | 213 | 50321658 |
Chloropsia | 20.83 | 9.89 | 8 | 283245 | 32 | 50321839 |
Eructation | 20.77 | 9.89 | 87 | 283166 | 7034 | 50314837 |
End stage renal disease | 20.74 | 9.89 | 75 | 283178 | 5662 | 50316209 |
Renal impairment neonatal | 20.64 | 9.89 | 8 | 283245 | 33 | 50321838 |
Respiratory disorder | 20.58 | 9.89 | 97 | 283156 | 31090 | 50290781 |
Atrial septal defect | 20.51 | 9.89 | 80 | 283173 | 6261 | 50315610 |
Cerebrospinal fluid retention | 20.49 | 9.89 | 10 | 283243 | 79 | 50321792 |
Urachal abnormality | 20.48 | 9.89 | 13 | 283240 | 179 | 50321692 |
Rectourethral fistula | 20.45 | 9.89 | 8 | 283245 | 34 | 50321837 |
Pharyngitis | 20.40 | 9.89 | 42 | 283211 | 17461 | 50304410 |
Haemorrhage | 20.36 | 9.89 | 416 | 282837 | 53025 | 50268846 |
Osmolar gap increased | 20.26 | 9.89 | 7 | 283246 | 19 | 50321852 |
Splenic rupture | 20.17 | 9.89 | 29 | 283224 | 1169 | 50320702 |
Dementia | 20.15 | 9.89 | 156 | 283097 | 15841 | 50306030 |
Liver disorder | 20.01 | 9.89 | 124 | 283129 | 37098 | 50284773 |
Hyperthermia | 19.99 | 9.89 | 9 | 283244 | 7687 | 50314184 |
Arrhythmia neonatal | 19.92 | 9.89 | 8 | 283245 | 37 | 50321834 |
Coagulopathy | 19.91 | 9.89 | 170 | 283083 | 17774 | 50304097 |
Device stimulation issue | 19.85 | 9.89 | 9 | 283244 | 59 | 50321812 |
Bronchiectasis | 19.83 | 9.89 | 17 | 283236 | 10266 | 50311605 |
Mouth ulceration | 19.79 | 9.89 | 85 | 283168 | 27939 | 50293932 |
Arteriosclerosis coronary artery | 19.76 | 9.89 | 90 | 283163 | 7546 | 50314325 |
Fryns syndrome | 19.72 | 9.89 | 9 | 283244 | 60 | 50321811 |
Persistent cloaca | 19.70 | 9.89 | 13 | 283240 | 192 | 50321679 |
Cardioversion | 19.70 | 9.89 | 28 | 283225 | 1117 | 50320754 |
Atrial thrombosis | 19.58 | 9.89 | 32 | 283221 | 1445 | 50320426 |
Pulseless electrical activity | 19.51 | 9.89 | 83 | 283170 | 6758 | 50315113 |
Embolic stroke | 19.49 | 9.89 | 53 | 283200 | 3431 | 50318440 |
Haematuria | 19.34 | 9.89 | 224 | 283029 | 25389 | 50296482 |
Diverticulum intestinal | 19.31 | 9.89 | 75 | 283178 | 5858 | 50316013 |
International normalised ratio decreased | 19.25 | 9.89 | 59 | 283194 | 4089 | 50317782 |
Sedation | 19.16 | 9.89 | 97 | 283156 | 30513 | 50291358 |
Amenorrhoea | 18.98 | 9.89 | 12 | 283241 | 8472 | 50313399 |
Blood parathyroid hormone decreased | 18.98 | 9.89 | 8 | 283245 | 7106 | 50314765 |
Fear | 18.96 | 9.89 | 143 | 283110 | 14406 | 50307465 |
Embolic cerebral infarction | 18.92 | 9.89 | 18 | 283235 | 462 | 50321409 |
Acne | 18.88 | 9.89 | 52 | 283201 | 19543 | 50302328 |
Schizophrenia | 18.67 | 9.89 | 9 | 283244 | 7388 | 50314483 |
Orthopnoea | 18.59 | 9.89 | 72 | 283181 | 5617 | 50316254 |
Congenital choroid plexus cyst | 18.47 | 9.89 | 15 | 283238 | 310 | 50321561 |
Malignant polyp | 18.38 | 9.89 | 12 | 283241 | 174 | 50321697 |
Patent ductus arteriosus | 18.35 | 9.89 | 55 | 283198 | 3765 | 50318106 |
Post procedural haemorrhage | 18.31 | 9.89 | 85 | 283168 | 7185 | 50314686 |
Device difficult to use | 18.27 | 9.89 | 17 | 283236 | 9869 | 50312002 |
Blood pressure abnormal | 18.16 | 9.89 | 128 | 283125 | 12619 | 50309252 |
Congenital acrochordon | 18.09 | 9.89 | 8 | 283245 | 49 | 50321822 |
Atrial tachycardia | 17.95 | 9.89 | 38 | 283215 | 2094 | 50319777 |
Myelosuppression | 17.91 | 9.89 | 30 | 283223 | 13487 | 50308384 |
Grip strength decreased | 17.89 | 9.89 | 25 | 283228 | 12096 | 50309775 |
Inhibitory drug interaction | 17.88 | 9.89 | 39 | 283214 | 2194 | 50319677 |
Haemorrhoidal haemorrhage | 17.81 | 9.89 | 53 | 283200 | 3614 | 50318257 |
Product residue present | 17.76 | 9.89 | 53 | 283200 | 3619 | 50318252 |
Blood albumin abnormal | 17.76 | 9.89 | 17 | 283236 | 440 | 50321431 |
Foot deformity | 17.75 | 9.89 | 52 | 283201 | 19158 | 50302713 |
Cardiac valve disease | 17.70 | 9.89 | 54 | 283199 | 3732 | 50318139 |
Ovarian cyst | 17.69 | 9.89 | 32 | 283221 | 13964 | 50307907 |
Ultrasound kidney abnormal | 17.67 | 9.89 | 7 | 283246 | 31 | 50321840 |
Head injury | 17.66 | 9.89 | 209 | 283044 | 23811 | 50298060 |
Sinus arrest | 17.58 | 9.89 | 33 | 283220 | 1665 | 50320206 |
Degenerative aortic valve disease | 17.55 | 9.89 | 9 | 283244 | 80 | 50321791 |
Malignant neoplasm progression | 17.45 | 9.89 | 272 | 282981 | 67852 | 50254019 |
Myocardial necrosis marker increased | 17.44 | 9.89 | 31 | 283222 | 1499 | 50320372 |
Neutrophil function disorder | 17.44 | 9.89 | 6 | 283247 | 16 | 50321855 |
Serotonin syndrome | 17.42 | 9.89 | 75 | 283178 | 24638 | 50297233 |
Phaeochromocytoma | 17.41 | 9.89 | 17 | 283236 | 451 | 50321420 |
Hypokalaemia | 17.40 | 9.89 | 629 | 282624 | 87363 | 50234508 |
Sinus node dysfunction | 17.19 | 9.89 | 55 | 283198 | 3900 | 50317971 |
Metastases to bone | 17.15 | 9.89 | 48 | 283205 | 17947 | 50303924 |
Coma | 17.08 | 9.89 | 220 | 283033 | 56659 | 50265212 |
Subarachnoid haemorrhage | 17.02 | 9.89 | 111 | 283142 | 10665 | 50311206 |
Lymphatic fistula | 17.01 | 9.89 | 21 | 283232 | 729 | 50321142 |
Extrasystoles | 16.95 | 9.89 | 61 | 283192 | 4594 | 50317277 |
Hyperammonaemia | 16.91 | 9.89 | 3 | 283250 | 4721 | 50317150 |
Haemorrhage intracranial | 16.91 | 9.89 | 123 | 283130 | 12251 | 50309620 |
Aortic aneurysm | 16.81 | 9.89 | 48 | 283205 | 3197 | 50318674 |
Negative cardiac inotropic effect | 16.76 | 9.89 | 4 | 283249 | 0 | 50321871 |
Adrenalectomy | 16.76 | 9.89 | 4 | 283249 | 0 | 50321871 |
Femoral hernia incarcerated | 16.76 | 9.89 | 21 | 283232 | 740 | 50321131 |
Unevaluable event | 16.70 | 9.89 | 356 | 282897 | 45710 | 50276161 |
Electrocardiogram T wave inversion | 16.67 | 9.89 | 48 | 283205 | 3213 | 50318658 |
Left-to-right cardiac shunt | 16.58 | 9.89 | 10 | 283243 | 125 | 50321746 |
Chronic obstructive pulmonary disease | 16.58 | 9.89 | 404 | 282849 | 53031 | 50268840 |
Congenital nail disorder | 16.56 | 9.89 | 9 | 283244 | 91 | 50321780 |
Hypovolaemia | 16.51 | 9.89 | 100 | 283153 | 9365 | 50312506 |
Arteriovenous fistula occlusion | 16.46 | 9.89 | 15 | 283238 | 364 | 50321507 |
Liver injury | 16.46 | 9.89 | 77 | 283176 | 24729 | 50297142 |
Anhedonia | 16.22 | 9.89 | 100 | 283153 | 9424 | 50312447 |
Aortic stenosis | 16.16 | 9.89 | 56 | 283197 | 4138 | 50317733 |
Drug level increased | 16.14 | 9.89 | 172 | 283081 | 19096 | 50302775 |
Flatulence | 16.13 | 9.89 | 243 | 283010 | 29215 | 50292656 |
Cardiac operation | 16.12 | 9.89 | 43 | 283210 | 2752 | 50319119 |
Stent placement | 16.04 | 9.89 | 49 | 283204 | 3389 | 50318482 |
Hyperlipidaemia | 16.02 | 9.89 | 159 | 283094 | 17331 | 50304540 |
Cerebral infarction | 15.89 | 9.89 | 188 | 283065 | 21416 | 50300455 |
Aortic valve sclerosis | 15.82 | 9.89 | 24 | 283229 | 1016 | 50320855 |
Tuberculosis | 15.69 | 9.89 | 20 | 283233 | 10063 | 50311808 |
Renal function test abnormal | 15.60 | 9.89 | 43 | 283210 | 2806 | 50319065 |
Poor venous access | 15.59 | 9.89 | 21 | 283232 | 10319 | 50311552 |
Drug therapeutic incompatibility | 15.55 | 9.89 | 7 | 283246 | 45 | 50321826 |
Product quality issue | 15.55 | 9.89 | 251 | 283002 | 30607 | 50291264 |
Hypocapnia | 15.53 | 9.89 | 14 | 283239 | 335 | 50321536 |
Neonatal respiratory failure | 15.46 | 9.89 | 11 | 283242 | 185 | 50321686 |
Occult blood positive | 15.45 | 9.89 | 47 | 283206 | 3244 | 50318627 |
Shock | 15.32 | 9.89 | 180 | 283073 | 20470 | 50301401 |
Foreign body | 15.30 | 9.89 | 34 | 283219 | 1937 | 50319934 |
Traumatic haemorrhage | 15.29 | 9.89 | 16 | 283237 | 462 | 50321409 |
Skin hypertrophy | 15.28 | 9.89 | 45 | 283208 | 3050 | 50318821 |
Pneumonia | 15.23 | 9.89 | 2376 | 280877 | 376025 | 49945846 |
Therapy partial responder | 15.20 | 9.89 | 9 | 283244 | 6582 | 50315289 |
Cardioactive drug level increased | 15.15 | 9.89 | 34 | 283219 | 1950 | 50319921 |
Renal dysplasia | 15.14 | 9.89 | 10 | 283243 | 148 | 50321723 |
Sleep apnoea syndrome | 15.12 | 9.89 | 202 | 283051 | 23666 | 50298205 |
Enterocolitis | 15.10 | 9.89 | 9 | 283244 | 6558 | 50315313 |
Ejection fraction abnormal | 15.00 | 9.89 | 21 | 283232 | 826 | 50321045 |
Carotid artery occlusion | 14.94 | 9.89 | 39 | 283214 | 2464 | 50319407 |
Pancreatic steatosis | 14.93 | 9.89 | 22 | 283231 | 907 | 50320964 |
Oesophagitis chemical | 14.90 | 9.89 | 5 | 283248 | 12 | 50321859 |
Hypoacusis | 14.89 | 9.89 | 179 | 283074 | 20468 | 50301403 |
Graft versus host disease | 14.82 | 9.89 | 8 | 283245 | 6158 | 50315713 |
Electrocardiogram QRS complex shortened | 14.74 | 9.89 | 15 | 283238 | 419 | 50321452 |
Alanine aminotransferase increased | 14.72 | 9.89 | 379 | 282874 | 87980 | 50233891 |
Injection site swelling | 14.70 | 9.89 | 156 | 283097 | 41617 | 50280254 |
Pulmonary tuberculosis | 14.69 | 9.89 | 3 | 283250 | 4270 | 50317601 |
Ischaemic hepatitis | 14.67 | 9.89 | 33 | 283220 | 1896 | 50319975 |
Gastrointestinal toxicity | 14.67 | 9.89 | 4 | 283249 | 4673 | 50317198 |
Supraventricular extrasystoles | 14.63 | 9.89 | 52 | 283201 | 3892 | 50317979 |
Alpha hydroxybutyrate dehydrogenase increased | 14.62 | 9.89 | 5 | 283248 | 13 | 50321858 |
Congenital diaphragmatic hernia | 14.59 | 9.89 | 11 | 283242 | 203 | 50321668 |
Fear of injection | 14.55 | 9.89 | 8 | 283245 | 6095 | 50315776 |
Cardiac valve abscess | 14.54 | 9.89 | 4 | 283249 | 3 | 50321868 |
Hypoxia | 14.53 | 9.89 | 382 | 282871 | 50741 | 50271130 |
Agranulocytosis | 14.50 | 9.89 | 66 | 283187 | 21355 | 50300516 |
Melaena | 14.48 | 9.89 | 221 | 283032 | 26643 | 50295228 |
Lacunar infarction | 14.41 | 9.89 | 44 | 283209 | 3043 | 50318828 |
Tooth erosion | 14.26 | 9.89 | 15 | 283238 | 436 | 50321435 |
Pathogen resistance | 14.24 | 9.89 | 7 | 283246 | 5682 | 50316189 |
Pulse absent | 14.24 | 9.89 | 59 | 283194 | 4747 | 50317124 |
Mitral valve sclerosis | 14.24 | 9.89 | 9 | 283244 | 123 | 50321748 |
Injection site pruritus | 14.18 | 9.89 | 151 | 283102 | 40260 | 50281611 |
Mood swings | 14.16 | 9.89 | 44 | 283209 | 15910 | 50305961 |
Pseudolymphoma | 14.16 | 9.89 | 17 | 283236 | 573 | 50321298 |
Haematotoxicity | 14.10 | 9.89 | 14 | 283239 | 7881 | 50313990 |
Dysphagia | 14.10 | 9.89 | 549 | 282704 | 76969 | 50244902 |
QRS axis abnormal | 14.08 | 9.89 | 22 | 283231 | 956 | 50320915 |
Glomerulonephritis rapidly progressive | 14.05 | 9.89 | 20 | 283233 | 799 | 50321072 |
Left ventricular hypertrophy | 13.98 | 9.89 | 59 | 283194 | 4786 | 50317085 |
Hepatic cyst | 13.98 | 9.89 | 56 | 283197 | 4437 | 50317434 |
Ischaemic cerebral infarction | 13.98 | 9.89 | 24 | 283229 | 1129 | 50320742 |
Blood cholesterol increased | 13.96 | 9.89 | 221 | 283032 | 54994 | 50266877 |
Haemorrhagic erosive gastritis | 13.92 | 9.89 | 12 | 283241 | 270 | 50321601 |
Colitis ulcerative | 13.91 | 9.89 | 48 | 283205 | 16806 | 50305065 |
Aortic valve disease | 13.89 | 9.89 | 21 | 283232 | 886 | 50320985 |
Gastric ulcer | 13.78 | 9.89 | 181 | 283072 | 21124 | 50300747 |
Cardiac fibrillation | 13.77 | 9.89 | 15 | 283238 | 454 | 50321417 |
Optic neuritis | 13.77 | 9.89 | 11 | 283242 | 6879 | 50314992 |
Coeliac disease | 13.75 | 9.89 | 17 | 283236 | 8668 | 50313203 |
Pregnancy with contraceptive device | 13.74 | 9.89 | 3 | 283250 | 4076 | 50317795 |
Muscle spasms | 13.73 | 9.89 | 846 | 282407 | 124707 | 50197164 |
Arteriospasm coronary | 13.62 | 9.89 | 46 | 283207 | 3356 | 50318515 |
Chromaturia | 13.54 | 9.89 | 133 | 283120 | 14457 | 50307414 |
Mitral valve stenosis | 13.48 | 9.89 | 22 | 283231 | 992 | 50320879 |
Pericardial haemorrhage | 13.47 | 9.89 | 27 | 283226 | 1431 | 50320440 |
Loss of personal independence in daily activities | 13.46 | 9.89 | 294 | 282959 | 69756 | 50252115 |
Cerebral artery occlusion | 13.30 | 9.89 | 20 | 283233 | 840 | 50321031 |
Stent malfunction | 13.30 | 9.89 | 7 | 283246 | 66 | 50321805 |
Computerised tomogram head abnormal | 13.13 | 9.89 | 4 | 283249 | 6 | 50321865 |
Thrombin time prolonged | 13.13 | 9.89 | 8 | 283245 | 102 | 50321769 |
Vanishing bile duct syndrome | 13.12 | 9.89 | 17 | 283236 | 620 | 50321251 |
Aneurysm | 13.11 | 9.89 | 37 | 283216 | 2448 | 50319423 |
Faeces discoloured | 13.07 | 9.89 | 143 | 283110 | 15981 | 50305890 |
Respiratory failure | 13.06 | 9.89 | 630 | 282623 | 90551 | 50231320 |
Splenic haemorrhage | 12.97 | 9.89 | 10 | 283243 | 191 | 50321680 |
Epstein-Barr virus infection | 12.97 | 9.89 | 12 | 283241 | 6985 | 50314886 |
Dysgeusia | 12.92 | 9.89 | 297 | 282956 | 38619 | 50283252 |
Eosinophilia | 12.91 | 9.89 | 57 | 283196 | 18595 | 50303276 |
Complication of device insertion | 12.90 | 9.89 | 9 | 283244 | 6032 | 50315839 |
Peritonitis bacterial | 12.87 | 9.89 | 56 | 283197 | 4605 | 50317266 |
Cerebral ventricular rupture | 12.84 | 9.89 | 10 | 283243 | 194 | 50321677 |
Demyelination | 12.84 | 9.89 | 9 | 283244 | 6017 | 50315854 |
Lung disorder | 12.82 | 9.89 | 175 | 283078 | 44624 | 50277247 |
Hypothyroidism | 12.78 | 9.89 | 265 | 282988 | 33860 | 50288011 |
Hypoaldosteronism | 12.77 | 9.89 | 9 | 283244 | 149 | 50321722 |
Fibromyalgia | 12.76 | 9.89 | 176 | 283077 | 44802 | 50277069 |
Hospice care | 12.75 | 9.89 | 65 | 283188 | 5707 | 50316164 |
Neuroleptic malignant syndrome | 12.73 | 9.89 | 27 | 283226 | 11103 | 50310768 |
Electrocardiogram QT interval abnormal | 12.71 | 9.89 | 9 | 283244 | 150 | 50321721 |
Ear infection | 12.71 | 9.89 | 89 | 283164 | 25881 | 50295990 |
Ventricular tachyarrhythmia | 12.69 | 9.89 | 7 | 283246 | 73 | 50321798 |
Calciphylaxis | 12.69 | 9.89 | 38 | 283215 | 2600 | 50319271 |
Intentional underdose | 12.62 | 9.89 | 28 | 283225 | 1594 | 50320277 |
Foetal renal impairment | 12.57 | 9.89 | 3 | 283250 | 0 | 50321871 |
Aortic aneurysm repair | 12.57 | 9.89 | 3 | 283250 | 0 | 50321871 |
Electrocardiogram RR interval prolonged | 12.57 | 9.89 | 3 | 283250 | 0 | 50321871 |
Diabetic enteropathy | 12.57 | 9.89 | 3 | 283250 | 0 | 50321871 |
Photophobia | 12.56 | 9.89 | 42 | 283211 | 14845 | 50307026 |
Malignant hypertension | 12.55 | 9.89 | 22 | 283231 | 1052 | 50320819 |
Capillary disorder | 12.53 | 9.89 | 7 | 283246 | 75 | 50321796 |
Retroperitoneal haemorrhage | 12.47 | 9.89 | 37 | 283216 | 2519 | 50319352 |
Ankylosing spondylitis | 12.46 | 9.89 | 13 | 283240 | 7152 | 50314719 |
Dialysis | 12.43 | 9.89 | 93 | 283160 | 9345 | 50312526 |
Carotid artery stenosis | 12.42 | 9.89 | 56 | 283197 | 4675 | 50317196 |
Myocardial hypoxia | 12.42 | 9.89 | 4 | 283249 | 8 | 50321863 |
Cyanopsia | 12.42 | 9.89 | 4 | 283249 | 8 | 50321863 |
Device use error | 12.41 | 9.89 | 7 | 283246 | 5259 | 50316612 |
Rectal haemorrhage | 12.41 | 9.89 | 293 | 282960 | 38265 | 50283606 |
Feeling abnormal | 12.35 | 9.89 | 838 | 282415 | 124654 | 50197217 |
Haemorrhagic stroke | 12.35 | 9.89 | 60 | 283193 | 5168 | 50316703 |
Sleep disorder | 12.32 | 9.89 | 236 | 283017 | 57047 | 50264824 |
HELLP syndrome | 12.30 | 9.89 | 20 | 283233 | 899 | 50320972 |
Post-anoxic myoclonus | 12.30 | 9.89 | 5 | 283248 | 24 | 50321847 |
Lymphadenopathy | 12.24 | 9.89 | 124 | 283129 | 33375 | 50288496 |
Fracture blisters | 12.22 | 9.89 | 7 | 283246 | 79 | 50321792 |
Diet noncompliance | 12.21 | 9.89 | 11 | 283242 | 263 | 50321608 |
Cardiac discomfort | 12.20 | 9.89 | 19 | 283234 | 823 | 50321048 |
Tracheo-oesophageal fistula | 12.19 | 9.89 | 15 | 283238 | 519 | 50321352 |
Gastritis erosive | 12.18 | 9.89 | 59 | 283194 | 5075 | 50316796 |
Circulatory collapse | 12.15 | 9.89 | 168 | 283085 | 19832 | 50302039 |
Congenital uterine anomaly | 12.13 | 9.89 | 8 | 283245 | 118 | 50321753 |
Thrombotic microangiopathy | 12.13 | 9.89 | 19 | 283234 | 8772 | 50313099 |
Menstruation irregular | 12.11 | 9.89 | 10 | 283243 | 6152 | 50315719 |
Antithyroid arthritis syndrome | 12.10 | 9.89 | 4 | 283249 | 9 | 50321862 |
Spinal cord haematoma | 12.08 | 9.89 | 9 | 283244 | 163 | 50321708 |
Embolism arterial | 12.02 | 9.89 | 19 | 283234 | 834 | 50321037 |
Brain contusion | 12.01 | 9.89 | 15 | 283238 | 527 | 50321344 |
Blood pressure immeasurable | 12.00 | 9.89 | 22 | 283231 | 1090 | 50320781 |
Blood magnesium decreased | 12 | 9.89 | 105 | 283148 | 11055 | 50310816 |
Essential hypertension | 11.97 | 9.89 | 53 | 283200 | 4391 | 50317480 |
Kyphosis | 11.94 | 9.89 | 34 | 283219 | 2261 | 50319610 |
Angiocardiogram | 11.92 | 9.89 | 6 | 283247 | 51 | 50321820 |
Bronchopulmonary aspergillosis | 11.88 | 9.89 | 15 | 283238 | 7577 | 50314294 |
Aphthous ulcer | 11.87 | 9.89 | 26 | 283227 | 10571 | 50311300 |
Palmar-plantar erythrodysaesthesia syndrome | 11.85 | 9.89 | 65 | 283188 | 20033 | 50301838 |
Epinephrine increased | 11.81 | 9.89 | 4 | 283249 | 10 | 50321861 |
Disease recurrence | 11.81 | 9.89 | 65 | 283188 | 20016 | 50301855 |
Embolism venous | 11.79 | 9.89 | 36 | 283217 | 2489 | 50319382 |
Food allergy | 11.79 | 9.89 | 17 | 283236 | 8120 | 50313751 |
Skin tightness | 11.79 | 9.89 | 47 | 283206 | 3716 | 50318155 |
Blood potassium increased | 11.76 | 9.89 | 142 | 283111 | 16256 | 50305615 |
Subclavian vein thrombosis | 11.75 | 9.89 | 29 | 283224 | 1770 | 50320101 |
Tachycardia induced cardiomyopathy | 11.73 | 9.89 | 6 | 283247 | 53 | 50321818 |
Alveolitis | 11.72 | 9.89 | 36 | 283217 | 2498 | 50319373 |
Gastrointestinal arteriovenous malformation | 11.70 | 9.89 | 15 | 283238 | 541 | 50321330 |
Peripheral vascular disorder | 11.68 | 9.89 | 61 | 283192 | 5406 | 50316465 |
Electrocardiogram QRS complex prolonged | 11.68 | 9.89 | 60 | 283193 | 5284 | 50316587 |
Genital labial adhesions | 11.68 | 9.89 | 5 | 283248 | 28 | 50321843 |
Pulmonary hypoplasia | 11.67 | 9.89 | 11 | 283242 | 279 | 50321592 |
Renal aplasia | 11.60 | 9.89 | 10 | 283243 | 225 | 50321646 |
Cardio-respiratory arrest | 11.59 | 9.89 | 389 | 282864 | 53503 | 50268368 |
Gastroenteritis clostridial | 11.58 | 9.89 | 15 | 283238 | 547 | 50321324 |
Echocardiogram abnormal | 11.54 | 9.89 | 22 | 283231 | 1123 | 50320748 |
Ulcer | 11.54 | 9.89 | 66 | 283187 | 20134 | 50301737 |
Positron emission tomogram abnormal | 11.54 | 9.89 | 9 | 283244 | 175 | 50321696 |
Hypoperfusion | 11.54 | 9.89 | 24 | 283229 | 1306 | 50320565 |
Blood electrolytes decreased | 11.53 | 9.89 | 21 | 283232 | 1035 | 50320836 |
Arterial stent insertion | 11.53 | 9.89 | 5 | 283248 | 29 | 50321842 |
Maternal exposure timing unspecified | 11.53 | 9.89 | 3 | 283250 | 3617 | 50318254 |
Rash erythematous | 11.53 | 9.89 | 132 | 283121 | 34720 | 50287151 |
Polyhydramnios | 11.53 | 9.89 | 31 | 283222 | 1994 | 50319877 |
Epilepsy | 11.51 | 9.89 | 72 | 283181 | 21495 | 50300376 |
Hypogammaglobulinaemia | 11.51 | 9.89 | 9 | 283244 | 5690 | 50316181 |
Coronary artery restenosis | 11.51 | 9.89 | 12 | 283241 | 345 | 50321526 |
Disability | 11.50 | 9.89 | 35 | 283218 | 12740 | 50309131 |
Head discomfort | 11.50 | 9.89 | 103 | 283150 | 10916 | 50310955 |
Hypertransaminasaemia | 11.49 | 9.89 | 3 | 283250 | 3608 | 50318263 |
Ear pain | 11.48 | 9.89 | 102 | 283151 | 28181 | 50293690 |
Non-high-density lipoprotein cholesterol increased | 11.47 | 9.89 | 8 | 283245 | 130 | 50321741 |
Aortic arteriosclerosis | 11.47 | 9.89 | 60 | 283193 | 5322 | 50316549 |
Multiple drug therapy | 11.38 | 9.89 | 30 | 283223 | 1907 | 50319964 |
Urinary retention | 11.37 | 9.89 | 208 | 283045 | 25982 | 50295889 |
Haemodialysis | 11.35 | 9.89 | 83 | 283170 | 8279 | 50313592 |
Seroma | 11.31 | 9.89 | 29 | 283224 | 1812 | 50320059 |
Infection susceptibility increased | 11.29 | 9.89 | 36 | 283217 | 2548 | 50319323 |
Urogenital haemorrhage | 11.28 | 9.89 | 10 | 283243 | 234 | 50321637 |
Blood pressure systolic abnormal | 11.27 | 9.89 | 16 | 283237 | 7690 | 50314181 |
Septic shock | 11.26 | 9.89 | 239 | 283014 | 56936 | 50264935 |
Conjunctival cyst | 11.18 | 9.89 | 6 | 283247 | 59 | 50321812 |
Myxoedema | 11.18 | 9.89 | 7 | 283246 | 94 | 50321777 |
Central nervous system injury | 11.17 | 9.89 | 8 | 283245 | 136 | 50321735 |
Mydriasis | 11.16 | 9.89 | 27 | 283226 | 10600 | 50311271 |
Vascular stent thrombosis | 11.12 | 9.89 | 19 | 283234 | 890 | 50320981 |
Systemic infection | 11.09 | 9.89 | 33 | 283220 | 2250 | 50319621 |
Arrhythmia supraventricular | 11.03 | 9.89 | 19 | 283234 | 896 | 50320975 |
Prothrombin time prolonged | 11.03 | 9.89 | 86 | 283167 | 8752 | 50313119 |
Product name confusion | 11.01 | 9.89 | 6 | 283247 | 61 | 50321810 |
Splenic injury | 11.00 | 9.89 | 9 | 283244 | 188 | 50321683 |
Basal cell carcinoma | 10.96 | 9.89 | 81 | 283172 | 23275 | 50298596 |
Leukopenia | 10.89 | 9.89 | 291 | 282962 | 67237 | 50254634 |
Peripheral artery thrombosis | 10.88 | 9.89 | 27 | 283226 | 1653 | 50320218 |
Oropharyngeal pain | 10.86 | 9.89 | 342 | 282911 | 77459 | 50244412 |
Metabolic encephalopathy | 10.85 | 9.89 | 57 | 283196 | 5064 | 50316807 |
Duplicate therapy error | 10.85 | 9.89 | 6 | 283247 | 63 | 50321808 |
Therapeutic product effect increased | 10.84 | 9.89 | 20 | 283233 | 996 | 50320875 |
Optic ischaemic neuropathy | 10.83 | 9.89 | 20 | 283233 | 997 | 50320874 |
Haemorrhagic transformation stroke | 10.80 | 9.89 | 21 | 283232 | 1088 | 50320783 |
Immune reconstitution inflammatory syndrome | 10.78 | 9.89 | 9 | 283244 | 5507 | 50316364 |
Rabbit syndrome | 10.76 | 9.89 | 11 | 283242 | 309 | 50321562 |
Uterine perforation | 10.76 | 9.89 | 12 | 283241 | 6403 | 50315468 |
Injection site bruising | 10.75 | 9.89 | 143 | 283110 | 36625 | 50285246 |
Reduced facial expression | 10.73 | 9.89 | 26 | 283227 | 1568 | 50320303 |
Aspiration pleural cavity | 10.72 | 9.89 | 17 | 283236 | 748 | 50321123 |
Hypochromic anaemia | 10.72 | 9.89 | 27 | 283226 | 1669 | 50320202 |
Respiratory tract congestion | 10.69 | 9.89 | 42 | 283211 | 14157 | 50307714 |
Gastric cyst | 10.69 | 9.89 | 7 | 283246 | 102 | 50321769 |
Urosepsis | 10.69 | 9.89 | 133 | 283120 | 15332 | 50306539 |
Eye haemorrhage | 10.65 | 9.89 | 74 | 283179 | 7261 | 50314610 |
Blood sodium decreased | 10.65 | 9.89 | 172 | 283081 | 20975 | 50300896 |
Hypomania | 10.60 | 9.89 | 6 | 283247 | 4499 | 50317372 |
Therapeutic drug monitoring analysis incorrectly performed | 10.55 | 9.89 | 8 | 283245 | 149 | 50321722 |
Chemical burn of oral cavity | 10.53 | 9.89 | 6 | 283247 | 67 | 50321804 |
Brain stem infarction | 10.52 | 9.89 | 17 | 283236 | 760 | 50321111 |
Intra-aortic balloon placement | 10.51 | 9.89 | 3 | 283250 | 3 | 50321868 |
Pacemaker syndrome | 10.51 | 9.89 | 3 | 283250 | 3 | 50321868 |
Diverticulum | 10.46 | 9.89 | 98 | 283155 | 10516 | 50311355 |
Nervousness | 10.45 | 9.89 | 215 | 283038 | 27436 | 50294435 |
Heavy menstrual bleeding | 10.44 | 9.89 | 48 | 283205 | 15489 | 50306382 |
Dyschromatopsia | 10.44 | 9.89 | 12 | 283241 | 386 | 50321485 |
Lacrimal gland enlargement | 10.42 | 9.89 | 4 | 283249 | 16 | 50321855 |
Extra dose administered | 10.41 | 9.89 | 56 | 283197 | 5020 | 50316851 |
Anaphylactic shock | 10.39 | 9.89 | 68 | 283185 | 20087 | 50301784 |
Amaurosis fugax | 10.36 | 9.89 | 12 | 283241 | 389 | 50321482 |
Mitral valve calcification | 10.36 | 9.89 | 19 | 283234 | 942 | 50320929 |
Environmental exposure | 10.30 | 9.89 | 6 | 283247 | 70 | 50321801 |
Metastases to fallopian tube | 10.30 | 9.89 | 5 | 283248 | 39 | 50321832 |
Upper gastrointestinal haemorrhage | 10.28 | 9.89 | 136 | 283117 | 15899 | 50305972 |
Galactorrhoea | 10.24 | 9.89 | 4 | 283249 | 3719 | 50318152 |
Neurotoxicity | 10.23 | 9.89 | 45 | 283208 | 14695 | 50307176 |
Facial bones fracture | 10.21 | 9.89 | 40 | 283213 | 3137 | 50318734 |
Mucosal haemorrhage | 10.16 | 9.89 | 17 | 283236 | 783 | 50321088 |
Blood iron abnormal | 10.14 | 9.89 | 3 | 283250 | 3323 | 50318548 |
International normalised ratio abnormal | 10.13 | 9.89 | 37 | 283216 | 2806 | 50319065 |
Incorrect route of product administration | 10.13 | 9.89 | 62 | 283191 | 18604 | 50303267 |
Reaction to excipient | 10.12 | 9.89 | 21 | 283232 | 1141 | 50320730 |
Mesenteric haemorrhage | 10.09 | 9.89 | 5 | 283248 | 41 | 50321830 |
Neonatal anuria | 10.09 | 9.89 | 5 | 283248 | 41 | 50321830 |
Multiple-drug resistance | 10.08 | 9.89 | 3 | 283250 | 3311 | 50318560 |
Tongue blistering | 10.07 | 9.89 | 23 | 283230 | 1335 | 50320536 |
Cerebellar haemorrhage | 10.05 | 9.89 | 22 | 283231 | 1241 | 50320630 |
Cerebral ischaemia | 10.04 | 9.89 | 62 | 283191 | 5846 | 50316025 |
Eczema eyelids | 10.03 | 9.89 | 7 | 283246 | 114 | 50321757 |
Urinary tract infection bacterial | 10.02 | 9.89 | 48 | 283205 | 4111 | 50317760 |
Toxic skin eruption | 10.01 | 9.89 | 31 | 283222 | 11220 | 50310651 |
Catheterisation cardiac | 10 | 9.89 | 47 | 283206 | 3993 | 50317878 |
Subclavian artery stenosis | 9.99 | 9.89 | 8 | 283245 | 162 | 50321709 |
Hallucination, visual | 9.96 | 9.89 | 139 | 283114 | 16443 | 50305428 |
Unwanted awareness during anaesthesia | 9.95 | 9.89 | 10 | 283243 | 275 | 50321596 |
Body mass index abnormal | 9.95 | 9.89 | 6 | 283247 | 75 | 50321796 |
Wound infection pseudomonas | 9.93 | 9.89 | 22 | 283231 | 1251 | 50320620 |
Paradoxical drug reaction | 9.89 | 9.89 | 4 | 283249 | 3643 | 50318228 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myocardial infarction | 1229.41 | 10.91 | 2811 | 247350 | 107485 | 29216881 |
Cardiac failure congestive | 649.43 | 10.91 | 1760 | 248401 | 74821 | 29249545 |
Coronary artery disease | 611.48 | 10.91 | 1231 | 248930 | 42959 | 29281407 |
Bradycardia | 482.62 | 10.91 | 1433 | 248728 | 64196 | 29260170 |
Atrial fibrillation | 479.28 | 10.91 | 1965 | 248196 | 103681 | 29220685 |
Acute myocardial infarction | 342.08 | 10.91 | 1043 | 249118 | 47395 | 29276971 |
Off label use | 335.29 | 10.91 | 1360 | 248801 | 299440 | 29024926 |
Coronary artery bypass | 317.04 | 10.91 | 285 | 249876 | 4400 | 29319966 |
Drug abuse | 308.11 | 10.91 | 145 | 250016 | 79738 | 29244628 |
Dizziness | 280.81 | 10.91 | 2639 | 247522 | 187045 | 29137321 |
Hypotension | 268.99 | 10.91 | 2666 | 247495 | 191688 | 29132678 |
Syncope | 262.27 | 10.91 | 1370 | 248791 | 80001 | 29244365 |
Product prescribing error | 229.84 | 10.91 | 485 | 249676 | 17491 | 29306875 |
Drug ineffective | 198.17 | 10.91 | 2042 | 248119 | 361128 | 28963238 |
Febrile neutropenia | 190.71 | 10.91 | 416 | 249745 | 111824 | 29212542 |
Coronary arterial stent insertion | 179.34 | 10.91 | 192 | 249969 | 3705 | 29320661 |
Dyspnoea | 177.84 | 10.91 | 3806 | 246355 | 322926 | 29001440 |
Neutropenia | 175.80 | 10.91 | 551 | 249610 | 131160 | 29193206 |
Cerebrovascular accident | 163.70 | 10.91 | 1163 | 248998 | 75748 | 29248618 |
Angina unstable | 142.20 | 10.91 | 296 | 249865 | 10569 | 29313797 |
Pyrexia | 135.34 | 10.91 | 1671 | 248490 | 285951 | 29038415 |
Drug reaction with eosinophilia and systemic symptoms | 127.52 | 10.91 | 39 | 250122 | 27953 | 29296413 |
Product use in unapproved indication | 125.54 | 10.91 | 350 | 249811 | 86525 | 29237841 |
Hepatic function abnormal | 122.10 | 10.91 | 92 | 250069 | 39167 | 29285199 |
Angina pectoris | 115.80 | 10.91 | 505 | 249656 | 27345 | 29297021 |
Cardiac disorder | 113.48 | 10.91 | 618 | 249543 | 36645 | 29287721 |
Fall | 107.84 | 10.91 | 2100 | 248061 | 175078 | 29149288 |
Chest pain | 101.83 | 10.91 | 1418 | 248743 | 110555 | 29213811 |
Completed suicide | 95.90 | 10.91 | 1176 | 248985 | 89070 | 29235296 |
Asthenia | 94.37 | 10.91 | 2435 | 247726 | 212815 | 29111551 |
Treatment failure | 93.04 | 10.91 | 105 | 250056 | 36834 | 29287532 |
Atrial flutter | 88.62 | 10.91 | 289 | 249872 | 13605 | 29310761 |
Interstitial lung disease | 86.75 | 10.91 | 228 | 249933 | 57490 | 29266876 |
Vascular graft | 83.74 | 10.91 | 79 | 250082 | 1301 | 29323065 |
Ventricular tachycardia | 78.12 | 10.91 | 388 | 249773 | 22186 | 29302180 |
General physical health deterioration | 76.59 | 10.91 | 1259 | 248902 | 101598 | 29222768 |
Haematochezia | 76.14 | 10.91 | 555 | 249606 | 36428 | 29287938 |
Mucosal inflammation | 73.02 | 10.91 | 96 | 250065 | 31499 | 29292867 |
Coronary artery occlusion | 71.76 | 10.91 | 218 | 249943 | 9876 | 29314490 |
Fatigue | 71.61 | 10.91 | 3319 | 246842 | 313502 | 29010864 |
Arrhythmia | 71.54 | 10.91 | 482 | 249679 | 30831 | 29293535 |
Neutrophil count decreased | 70.22 | 10.91 | 166 | 249995 | 43401 | 29280965 |
Drug resistance | 70.21 | 10.91 | 48 | 250113 | 21492 | 29302874 |
Hypertensive emergency | 69.04 | 10.91 | 57 | 250104 | 779 | 29323587 |
Acute coronary syndrome | 66.08 | 10.91 | 242 | 249919 | 12083 | 29312283 |
Eosinophilia | 65.05 | 10.91 | 55 | 250106 | 22106 | 29302260 |
International normalised ratio increased | 64.64 | 10.91 | 616 | 249545 | 43756 | 29280610 |
Therapeutic product effect incomplete | 62.36 | 10.91 | 151 | 250010 | 39154 | 29285212 |
Septic shock | 61.90 | 10.91 | 295 | 249866 | 62265 | 29262101 |
Asthma | 60.30 | 10.91 | 122 | 250039 | 33727 | 29290639 |
Infusion related reaction | 60.28 | 10.91 | 181 | 249980 | 43705 | 29280661 |
Hepatocellular injury | 57.27 | 10.91 | 57 | 250104 | 21186 | 29303180 |
Gastrointestinal haemorrhage | 57.14 | 10.91 | 968 | 249193 | 78565 | 29245801 |
Suicidal ideation | 56.96 | 10.91 | 131 | 250030 | 34585 | 29289781 |
Bone marrow failure | 56.93 | 10.91 | 90 | 250071 | 27359 | 29297007 |
Lower respiratory tract infection | 54.86 | 10.91 | 87 | 250074 | 26415 | 29297951 |
Thrombocytopenia | 54.21 | 10.91 | 808 | 249353 | 134015 | 29190351 |
Sinus bradycardia | 53.35 | 10.91 | 217 | 249944 | 11386 | 29312980 |
Pneumocystis jirovecii pneumonia | 52.57 | 10.91 | 39 | 250122 | 16740 | 29307626 |
Myocardial ischaemia | 52.30 | 10.91 | 271 | 249890 | 15757 | 29308609 |
Product monitoring error | 52.18 | 10.91 | 86 | 250075 | 2559 | 29321807 |
Sopor | 52.07 | 10.91 | 14 | 250147 | 10920 | 29313446 |
Drug dependence | 51.35 | 10.91 | 61 | 250100 | 20920 | 29303446 |
Cytomegalovirus infection | 51.16 | 10.91 | 73 | 250088 | 23142 | 29301224 |
Immune reconstitution inflammatory syndrome | 50.79 | 10.91 | 4 | 250157 | 7798 | 29316568 |
Product use issue | 50.64 | 10.91 | 243 | 249918 | 51201 | 29273165 |
Seizure | 49.84 | 10.91 | 525 | 249636 | 92598 | 29231768 |
Bronchopulmonary aspergillosis | 49.75 | 10.91 | 21 | 250140 | 12323 | 29312043 |
Rash maculo-papular | 49.09 | 10.91 | 81 | 250080 | 24208 | 29300158 |
Pathogen resistance | 48.04 | 10.91 | 6 | 250155 | 8110 | 29316256 |
Hepatic cytolysis | 47.43 | 10.91 | 7 | 250154 | 8340 | 29316026 |
Toxic skin eruption | 47.40 | 10.91 | 12 | 250149 | 9745 | 29314621 |
Coronary artery stenosis | 46.52 | 10.91 | 169 | 249992 | 8404 | 29315962 |
Agitation | 45.61 | 10.91 | 251 | 249910 | 51053 | 29273313 |
Dehydration | 45.52 | 10.91 | 1282 | 248879 | 113466 | 29210900 |
Aggression | 44.33 | 10.91 | 153 | 250008 | 35388 | 29288978 |
Palpitations | 43.75 | 10.91 | 445 | 249716 | 32159 | 29292207 |
Cardiac arrest | 43.31 | 10.91 | 988 | 249173 | 84603 | 29239763 |
Injury | 42.79 | 10.91 | 292 | 249869 | 18754 | 29305612 |
Toxic epidermal necrolysis | 42.10 | 10.91 | 55 | 250106 | 18098 | 29306268 |
Haematotoxicity | 42.07 | 10.91 | 4 | 250157 | 6695 | 29317671 |
Device interaction | 42.03 | 10.91 | 36 | 250125 | 519 | 29323847 |
Lymphopenia | 41.70 | 10.91 | 32 | 250129 | 13501 | 29310865 |
Liver disorder | 41.38 | 10.91 | 110 | 250051 | 27639 | 29296727 |
Rheumatoid arthritis | 41.06 | 10.91 | 137 | 250024 | 32015 | 29292351 |
Renal injury | 40.13 | 10.91 | 182 | 249979 | 10020 | 29314346 |
Suspected suicide | 39.74 | 10.91 | 98 | 250063 | 3922 | 29320444 |
Transient ischaemic attack | 39.49 | 10.91 | 334 | 249827 | 22936 | 29301430 |
Respiratory depression | 39.15 | 10.91 | 34 | 250127 | 13489 | 29310877 |
Nodal arrhythmia | 38.86 | 10.91 | 40 | 250121 | 736 | 29323630 |
Synovitis | 38.62 | 10.91 | 22 | 250139 | 10868 | 29313498 |
Irritability | 38.47 | 10.91 | 81 | 250080 | 22071 | 29302295 |
Disseminated intravascular coagulation | 38.21 | 10.91 | 69 | 250092 | 19911 | 29304455 |
Intentional product use issue | 37.72 | 10.91 | 208 | 249953 | 42290 | 29282076 |
Anhedonia | 37.45 | 10.91 | 140 | 250021 | 7060 | 29317306 |
Wound | 36.65 | 10.91 | 200 | 249961 | 11863 | 29312503 |
Malignant neoplasm progression | 36.48 | 10.91 | 424 | 249737 | 73435 | 29250931 |
Fear | 36.23 | 10.91 | 168 | 249993 | 9336 | 29315030 |
Oedema peripheral | 36.19 | 10.91 | 1139 | 249022 | 102418 | 29221948 |
Haemophagocytic lymphohistiocytosis | 36.15 | 10.91 | 22 | 250139 | 10482 | 29313884 |
Pancytopenia | 36.01 | 10.91 | 491 | 249670 | 82677 | 29241689 |
Infective pulmonary exacerbation of cystic fibrosis | 35.97 | 10.91 | 5 | 250156 | 6231 | 29318135 |
Substance abuse | 35.68 | 10.91 | 7 | 250154 | 6780 | 29317586 |
Atrioventricular block | 35.68 | 10.91 | 135 | 250026 | 6847 | 29317519 |
Agranulocytosis | 35.63 | 10.91 | 74 | 250087 | 20266 | 29304100 |
Ejection fraction decreased | 35.32 | 10.91 | 244 | 249917 | 15734 | 29308632 |
Aspergillus infection | 35.26 | 10.91 | 23 | 250138 | 10558 | 29313808 |
Drug hypersensitivity | 35.23 | 10.91 | 389 | 249772 | 68017 | 29256349 |
Myelosuppression | 35.08 | 10.91 | 31 | 250130 | 12196 | 29312170 |
Hyperthermia | 34.98 | 10.91 | 18 | 250143 | 9412 | 29314954 |
Atrioventricular block complete | 34.62 | 10.91 | 147 | 250014 | 7864 | 29316502 |
Haemorrhage intracranial | 34.50 | 10.91 | 226 | 249935 | 14316 | 29310050 |
Cholestasis | 34.24 | 10.91 | 94 | 250067 | 23368 | 29300998 |
C-reactive protein increased | 33.36 | 10.91 | 228 | 249933 | 44035 | 29280331 |
Acute generalised exanthematous pustulosis | 33.35 | 10.91 | 4 | 250157 | 5579 | 29318787 |
Progressive multifocal leukoencephalopathy | 33.31 | 10.91 | 16 | 250145 | 8703 | 29315663 |
Rhabdomyolysis | 33.30 | 10.91 | 710 | 249451 | 60098 | 29264268 |
Unevaluable event | 32.96 | 10.91 | 392 | 249769 | 29459 | 29294907 |
Acute graft versus host disease | 32.83 | 10.91 | 5 | 250156 | 5819 | 29318547 |
Acute lung injury | 32.81 | 10.91 | 48 | 250113 | 1285 | 29323081 |
Abnormal behaviour | 32.75 | 10.91 | 94 | 250067 | 23033 | 29301333 |
Drug eruption | 32.75 | 10.91 | 57 | 250104 | 16684 | 29307682 |
Overdose | 32.51 | 10.91 | 477 | 249684 | 79342 | 29245024 |
Coma | 32.38 | 10.91 | 198 | 249963 | 39252 | 29285114 |
Anaphylactic reaction | 32.20 | 10.91 | 122 | 250039 | 27451 | 29296915 |
Sinus node dysfunction | 31.74 | 10.91 | 86 | 250075 | 3648 | 29320718 |
Urticaria | 31.36 | 10.91 | 303 | 249858 | 54357 | 29270009 |
Labelled drug-drug interaction medication error | 31.35 | 10.91 | 193 | 249968 | 11966 | 29312400 |
Haematoma | 30.75 | 10.91 | 316 | 249845 | 22896 | 29301470 |
C-reactive protein abnormal | 29.95 | 10.91 | 9 | 250152 | 6527 | 29317839 |
Respiratory distress | 29.68 | 10.91 | 155 | 250006 | 31951 | 29292415 |
Therapeutic drug monitoring analysis not performed | 29.64 | 10.91 | 28 | 250133 | 462 | 29323904 |
Blood loss anaemia | 29.61 | 10.91 | 131 | 250030 | 7135 | 29317231 |
Altered state of consciousness | 29.53 | 10.91 | 79 | 250082 | 19810 | 29304556 |
Dyspnoea exertional | 29.50 | 10.91 | 453 | 249708 | 36037 | 29288329 |
Neuroleptic malignant syndrome | 28.92 | 10.91 | 58 | 250103 | 16090 | 29308276 |
Ascites | 28.92 | 10.91 | 186 | 249975 | 36433 | 29287933 |
Mitral valve incompetence | 28.80 | 10.91 | 202 | 249959 | 13091 | 29311275 |
Cardiac failure chronic | 28.20 | 10.91 | 119 | 250042 | 6348 | 29318018 |
Suicide attempt | 28.10 | 10.91 | 171 | 249990 | 33939 | 29290427 |
Obstructive airways disorder | 28.07 | 10.91 | 31 | 250130 | 10985 | 29313381 |
Myxoedema coma | 27.88 | 10.91 | 21 | 250140 | 249 | 29324117 |
Alanine aminotransferase increased | 27.84 | 10.91 | 427 | 249734 | 70517 | 29253849 |
Pacemaker generated rhythm | 27.75 | 10.91 | 13 | 250148 | 57 | 29324309 |
BRASH syndrome | 27.67 | 10.91 | 17 | 250144 | 140 | 29324226 |
Aortic stenosis | 27.58 | 10.91 | 84 | 250077 | 3810 | 29320556 |
Venoocclusive liver disease | 27.50 | 10.91 | 12 | 250149 | 6905 | 29317461 |
Anaphylactic shock | 27.39 | 10.91 | 44 | 250117 | 13292 | 29311074 |
Heart rate increased | 27.24 | 10.91 | 472 | 249689 | 38466 | 29285900 |
Catatonia | 27.20 | 10.91 | 3 | 250158 | 4465 | 29319901 |
Sinus arrest | 27.14 | 10.91 | 46 | 250115 | 1401 | 29322965 |
Graft versus host disease | 26.92 | 10.91 | 25 | 250136 | 9603 | 29314763 |
Atrial thrombosis | 26.90 | 10.91 | 55 | 250106 | 1938 | 29322428 |
Presyncope | 26.80 | 10.91 | 230 | 249931 | 15859 | 29308507 |
Orthostatic hypotension | 26.69 | 10.91 | 301 | 249860 | 22328 | 29302038 |
Heart rate decreased | 26.57 | 10.91 | 325 | 249836 | 24587 | 29299779 |
Chronotropic incompetence | 26.51 | 10.91 | 9 | 250152 | 12 | 29324354 |
Multiple organ dysfunction syndrome | 26.46 | 10.91 | 375 | 249786 | 62741 | 29261625 |
Mitral valve disease | 26.14 | 10.91 | 41 | 250120 | 1169 | 29323197 |
Stomatitis | 26.10 | 10.91 | 195 | 249966 | 36918 | 29287448 |
Foetal exposure during pregnancy | 25.74 | 10.91 | 174 | 249987 | 33693 | 29290673 |
Colitis | 25.56 | 10.91 | 157 | 250004 | 31091 | 29293275 |
Malaise | 25.48 | 10.91 | 1097 | 249064 | 158505 | 29165861 |
Abdominal pain lower | 25.43 | 10.91 | 142 | 250019 | 8496 | 29315870 |
Erythema multiforme | 25.41 | 10.91 | 17 | 250144 | 7700 | 29316666 |
Shone complex | 25.35 | 10.91 | 13 | 250148 | 72 | 29324294 |
Arteriosclerosis | 25.32 | 10.91 | 161 | 250000 | 10095 | 29314271 |
Extrapyramidal disorder | 24.93 | 10.91 | 33 | 250128 | 10798 | 29313568 |
Cardiac operation | 24.74 | 10.91 | 63 | 250098 | 2573 | 29321793 |
Psychomotor hyperactivity | 24.57 | 10.91 | 20 | 250141 | 8193 | 29316173 |
Exposure during pregnancy | 24.17 | 10.91 | 22 | 250139 | 8532 | 29315834 |
Epstein-Barr virus infection | 24.07 | 10.91 | 13 | 250148 | 6616 | 29317750 |
Peripheral vascular disorder | 23.91 | 10.91 | 89 | 250072 | 4478 | 29319888 |
Chronic graft versus host disease | 23.79 | 10.91 | 3 | 250158 | 4026 | 29320340 |
Sedation | 23.73 | 10.91 | 72 | 250089 | 17333 | 29307033 |
Blood creatinine increased | 23.46 | 10.91 | 911 | 249250 | 84191 | 29240175 |
Coagulopathy | 23.35 | 10.91 | 243 | 249918 | 17664 | 29306702 |
Hyponatraemia | 23.28 | 10.91 | 417 | 249744 | 67216 | 29257150 |
Hyperbilirubinaemia | 23.18 | 10.91 | 58 | 250103 | 14876 | 29309490 |
Renal failure | 22.99 | 10.91 | 1225 | 248936 | 117374 | 29206992 |
Multiple-drug resistance | 22.80 | 10.91 | 3 | 250158 | 3897 | 29320469 |
Status epilepticus | 22.75 | 10.91 | 35 | 250126 | 10759 | 29313607 |
Cardiac valve disease | 22.63 | 10.91 | 64 | 250097 | 2784 | 29321582 |
Hypertriglyceridaemia | 22.62 | 10.91 | 18 | 250143 | 7457 | 29316909 |
Blood glucose increased | 22.53 | 10.91 | 656 | 249505 | 58328 | 29266038 |
Carcinoma in situ of skin | 22.50 | 10.91 | 12 | 250149 | 73 | 29324293 |
Pancreatitis acute | 22.38 | 10.91 | 118 | 250043 | 24267 | 29300099 |
Fracture | 22.34 | 10.91 | 106 | 250055 | 5947 | 29318419 |
Headache | 22.09 | 10.91 | 1225 | 248936 | 172782 | 29151584 |
Hyperlipidaemia | 22.04 | 10.91 | 182 | 249979 | 12408 | 29311958 |
Troponin increased | 21.96 | 10.91 | 143 | 250018 | 9040 | 29315326 |
Supraventricular tachycardia | 21.88 | 10.91 | 151 | 250010 | 9733 | 29314633 |
Erythema | 21.85 | 10.91 | 480 | 249681 | 75126 | 29249240 |
Toxicity to various agents | 21.78 | 10.91 | 1224 | 248937 | 172437 | 29151929 |
Exercise tolerance decreased | 21.78 | 10.91 | 82 | 250079 | 4149 | 29320217 |
Leukopenia | 21.74 | 10.91 | 332 | 249829 | 54871 | 29269495 |
Aorta hypoplasia | 21.73 | 10.91 | 12 | 250149 | 79 | 29324287 |
Pericardial haemorrhage | 21.49 | 10.91 | 64 | 250097 | 2867 | 29321499 |
Blood pressure inadequately controlled | 21.34 | 10.91 | 56 | 250105 | 2330 | 29322036 |
Aspartate aminotransferase increased | 21.27 | 10.91 | 366 | 249795 | 59359 | 29265007 |
Contusion | 21.06 | 10.91 | 375 | 249786 | 30720 | 29293646 |
Arteriosclerosis coronary artery | 20.59 | 10.91 | 157 | 250004 | 10448 | 29313918 |
Circulatory collapse | 20.52 | 10.91 | 245 | 249916 | 18428 | 29305938 |
Pneumonia aspiration | 20.50 | 10.91 | 205 | 249956 | 36532 | 29287834 |
Infection | 20.29 | 10.91 | 494 | 249667 | 76257 | 29248109 |
Hypoalbuminaemia | 20.24 | 10.91 | 35 | 250126 | 10270 | 29314096 |
Epilepsy | 19.97 | 10.91 | 84 | 250077 | 18348 | 29306018 |
Sinusitis | 19.87 | 10.91 | 190 | 249971 | 34160 | 29290206 |
Hypertensive crisis | 19.87 | 10.91 | 124 | 250037 | 7724 | 29316642 |
Neuropathy vitamin B12 deficiency | 19.86 | 10.91 | 8 | 250153 | 22 | 29324344 |
Low density lipoprotein abnormal | 19.85 | 10.91 | 17 | 250144 | 245 | 29324121 |
Mental status changes | 19.82 | 10.91 | 410 | 249751 | 34517 | 29289849 |
Rash | 19.78 | 10.91 | 1361 | 248800 | 188458 | 29135908 |
Intracardiac thrombus | 19.65 | 10.91 | 53 | 250108 | 2242 | 29322124 |
Hepatitis B | 19.64 | 10.91 | 11 | 250150 | 5486 | 29318880 |
Ventricular extrasystoles | 19.63 | 10.91 | 155 | 250006 | 10427 | 29313939 |
Mouth ulceration | 19.59 | 10.91 | 36 | 250125 | 10319 | 29314047 |
Hyperkalaemia | 19.30 | 10.91 | 667 | 249494 | 60725 | 29263641 |
Immune thrombocytopenia | 19.17 | 10.91 | 23 | 250138 | 7854 | 29316512 |
Nephrogenic systemic fibrosis | 19.14 | 10.91 | 75 | 250086 | 3867 | 29320499 |
Ventricular hypokinesia | 19.13 | 10.91 | 83 | 250078 | 4482 | 29319884 |
Internal haemorrhage | 18.95 | 10.91 | 81 | 250080 | 4346 | 29320020 |
Postural orthostatic tachycardia syndrome | 18.94 | 10.91 | 9 | 250152 | 41 | 29324325 |
Autoimmune myositis | 18.91 | 10.91 | 11 | 250150 | 81 | 29324285 |
Hepatocellular carcinoma | 18.84 | 10.91 | 19 | 250142 | 7019 | 29317347 |
Emotional distress | 18.80 | 10.91 | 190 | 249971 | 13705 | 29310661 |
Sepsis | 18.74 | 10.91 | 1001 | 249160 | 141681 | 29182685 |
Drug intolerance | 18.70 | 10.91 | 292 | 249869 | 48087 | 29276279 |
Acute graft versus host disease in skin | 18.69 | 10.91 | 8 | 250153 | 4656 | 29319710 |
Upper motor neurone lesion | 18.66 | 10.91 | 12 | 250149 | 108 | 29324258 |
Basal ganglia haemorrhage | 18.64 | 10.91 | 28 | 250133 | 768 | 29323598 |
Uveitis | 18.40 | 10.91 | 14 | 250147 | 5933 | 29318433 |
Osteonecrosis | 18.38 | 10.91 | 56 | 250105 | 13463 | 29310903 |
Face oedema | 18.36 | 10.91 | 37 | 250124 | 10246 | 29314120 |
Chronic kidney disease | 18.28 | 10.91 | 420 | 249741 | 35996 | 29288370 |
Blood pressure abnormal | 18.28 | 10.91 | 109 | 250052 | 6681 | 29317685 |
Drug withdrawal syndrome | 18.25 | 10.91 | 84 | 250077 | 17900 | 29306466 |
Bundle branch block right | 18.19 | 10.91 | 108 | 250053 | 6609 | 29317757 |
Vomiting | 18.17 | 10.91 | 1547 | 248614 | 210713 | 29113653 |
Supravalvular aortic stenosis | 18.13 | 10.91 | 9 | 250152 | 46 | 29324320 |
Obsessive-compulsive disorder | 18.10 | 10.91 | 8 | 250153 | 4568 | 29319798 |
Fluid retention | 18.09 | 10.91 | 290 | 249871 | 23270 | 29301096 |
Cytokine release syndrome | 18.08 | 10.91 | 54 | 250107 | 13065 | 29311301 |
Oesophageal obstruction | 18.08 | 10.91 | 20 | 250141 | 401 | 29323965 |
Heart rate irregular | 18.06 | 10.91 | 180 | 249981 | 12937 | 29311429 |
Drug abuser | 18.03 | 10.91 | 5 | 250156 | 3822 | 29320544 |
Diffuse large B-cell lymphoma | 17.90 | 10.91 | 16 | 250145 | 6260 | 29318106 |
Tumour lysis syndrome | 17.83 | 10.91 | 59 | 250102 | 13825 | 29310541 |
Heart rate abnormal | 17.83 | 10.91 | 41 | 250120 | 1568 | 29322798 |
Stent placement | 17.82 | 10.91 | 78 | 250083 | 4228 | 29320138 |
Gout | 17.76 | 10.91 | 220 | 249941 | 16691 | 29307675 |
Therapy partial responder | 17.74 | 10.91 | 11 | 250150 | 5188 | 29319178 |
Hepatitis B reactivation | 17.69 | 10.91 | 3 | 250158 | 3226 | 29321140 |
Tuberculosis | 17.52 | 10.91 | 21 | 250140 | 7175 | 29317191 |
Non-cardiac chest pain | 17.40 | 10.91 | 73 | 250088 | 3884 | 29320482 |
Medication error | 17.40 | 10.91 | 264 | 249897 | 20947 | 29303419 |
Dysgeusia | 17.38 | 10.91 | 279 | 249882 | 22395 | 29301971 |
Tenosynovitis | 17.36 | 10.91 | 5 | 250156 | 3728 | 29320638 |
Cardiovascular disorder | 17.19 | 10.91 | 132 | 250029 | 8803 | 29315563 |
Cytopenia | 17.16 | 10.91 | 36 | 250125 | 9823 | 29314543 |
Akathisia | 17.15 | 10.91 | 19 | 250142 | 6723 | 29317643 |
Nodular rash | 17.10 | 10.91 | 11 | 250150 | 99 | 29324267 |
Neutropenic sepsis | 17.09 | 10.91 | 47 | 250114 | 11680 | 29312686 |
Cornea verticillata | 17.09 | 10.91 | 8 | 250153 | 35 | 29324331 |
Appendicitis | 17.07 | 10.91 | 30 | 250131 | 8749 | 29315617 |
Macrophages increased | 16.73 | 10.91 | 13 | 250148 | 162 | 29324204 |
Atrioventricular block first degree | 16.71 | 10.91 | 89 | 250072 | 5230 | 29319136 |
Drug-disease interaction | 16.70 | 10.91 | 18 | 250143 | 350 | 29324016 |
Occult blood positive | 16.61 | 10.91 | 69 | 250092 | 3655 | 29320711 |
Mitral valve hypoplasia | 16.58 | 10.91 | 8 | 250153 | 38 | 29324328 |
Orthostatic intolerance | 16.53 | 10.91 | 24 | 250137 | 638 | 29323728 |
Blood pressure increased | 16.50 | 10.91 | 773 | 249388 | 73030 | 29251336 |
Large for dates baby | 16.38 | 10.91 | 28 | 250133 | 859 | 29323507 |
Pulmonary tuberculosis | 16.36 | 10.91 | 8 | 250153 | 4307 | 29320059 |
Coronary angioplasty | 16.30 | 10.91 | 18 | 250143 | 360 | 29324006 |
Diabetic foetopathy | 16.22 | 10.91 | 14 | 250147 | 204 | 29324162 |
Bacterial parotitis | 16.20 | 10.91 | 6 | 250155 | 12 | 29324354 |
Lower gastrointestinal haemorrhage | 16.18 | 10.91 | 122 | 250039 | 8091 | 29316275 |
Aplastic anaemia | 16.17 | 10.91 | 24 | 250137 | 7486 | 29316880 |
Nodal rhythm | 16.16 | 10.91 | 35 | 250126 | 1285 | 29323081 |
Gastrointestinal tract mucosal pigmentation | 16.11 | 10.91 | 18 | 250143 | 365 | 29324001 |
Peripheral arterial occlusive disease | 15.99 | 10.91 | 85 | 250076 | 4991 | 29319375 |
Arthralgia | 15.89 | 10.91 | 993 | 249168 | 138624 | 29185742 |
Psoriatic arthropathy | 15.89 | 10.91 | 67 | 250094 | 14624 | 29309742 |
Leukoencephalopathy | 15.85 | 10.91 | 6 | 250155 | 3761 | 29320605 |
Blood glucose decreased | 15.84 | 10.91 | 164 | 249997 | 11905 | 29312461 |
Ventricular fibrillation | 15.79 | 10.91 | 204 | 249957 | 15629 | 29308737 |
Somnolence | 15.77 | 10.91 | 642 | 249519 | 93313 | 29231053 |
Dysmorphism | 15.76 | 10.91 | 3 | 250158 | 2968 | 29321398 |
Thrombotic microangiopathy | 15.70 | 10.91 | 31 | 250130 | 8650 | 29315716 |
Cytomegalovirus chorioretinitis | 15.70 | 10.91 | 4 | 250157 | 3234 | 29321132 |
Dizziness postural | 15.65 | 10.91 | 88 | 250073 | 5279 | 29319087 |
Pruritus genital | 15.60 | 10.91 | 21 | 250140 | 519 | 29323847 |
Full blood count decreased | 15.51 | 10.91 | 205 | 249956 | 15787 | 29308579 |
Blood urine present | 15.49 | 10.91 | 138 | 250023 | 9617 | 29314749 |
Product residue present | 15.46 | 10.91 | 52 | 250109 | 2487 | 29321879 |
Neuropathy peripheral | 15.43 | 10.91 | 470 | 249691 | 70557 | 29253809 |
Cardiac failure | 15.36 | 10.91 | 819 | 249342 | 78468 | 29245898 |
Therapeutic product effect decreased | 15.34 | 10.91 | 167 | 249994 | 29284 | 29295082 |
Plasma cell myeloma | 15.34 | 10.91 | 417 | 249744 | 36698 | 29287668 |
Intentional self-injury | 15.29 | 10.91 | 54 | 250107 | 12407 | 29311959 |
Nocturia | 15.24 | 10.91 | 122 | 250039 | 8240 | 29316126 |
Hepatitis | 15.19 | 10.91 | 108 | 250053 | 20675 | 29303691 |
Haemoglobin decreased | 15.15 | 10.91 | 1088 | 249073 | 107287 | 29217079 |
Electrocardiogram RR interval prolonged | 15.12 | 10.91 | 4 | 250157 | 0 | 29324366 |
Cerebral haemorrhage | 15.02 | 10.91 | 360 | 249801 | 31066 | 29293300 |
Alcohol abuse | 15.02 | 10.91 | 9 | 250152 | 4324 | 29320042 |
Drug withdrawal syndrome neonatal | 14.98 | 10.91 | 5 | 250156 | 3390 | 29320976 |
Cardiovascular insufficiency | 14.89 | 10.91 | 35 | 250126 | 1358 | 29323008 |
Graft versus host disease in skin | 14.87 | 10.91 | 5 | 250156 | 3374 | 29320992 |
Dyskinesia | 14.78 | 10.91 | 104 | 250057 | 19957 | 29304409 |
Pallor | 14.75 | 10.91 | 255 | 249906 | 20769 | 29303597 |
Exposure via ingestion | 14.73 | 10.91 | 44 | 250117 | 1974 | 29322392 |
Essential hypertension | 14.73 | 10.91 | 50 | 250111 | 2403 | 29321963 |
Pulmonary renal syndrome | 14.65 | 10.91 | 12 | 250149 | 162 | 29324204 |
Joint swelling | 14.64 | 10.91 | 314 | 249847 | 49316 | 29275050 |
Hypogammaglobulinaemia | 14.64 | 10.91 | 17 | 250144 | 5890 | 29318476 |
Asphyxia | 14.63 | 10.91 | 14 | 250147 | 5301 | 29319065 |
Post procedural haemorrhage | 14.60 | 10.91 | 111 | 250050 | 7380 | 29316986 |
Migraine | 14.51 | 10.91 | 55 | 250106 | 12375 | 29311991 |
Blood pressure orthostatic | 14.45 | 10.91 | 8 | 250153 | 53 | 29324313 |
Hepatojugular reflux | 14.44 | 10.91 | 19 | 250142 | 459 | 29323907 |
Extrasystoles | 14.43 | 10.91 | 63 | 250098 | 3411 | 29320955 |
Hyperferritinaemia | 14.41 | 10.91 | 16 | 250145 | 322 | 29324044 |
Haemodilution | 14.38 | 10.91 | 7 | 250154 | 34 | 29324332 |
Lung disorder | 14.33 | 10.91 | 176 | 249985 | 30186 | 29294180 |
Antiacetylcholine receptor antibody positive | 14.32 | 10.91 | 8 | 250153 | 54 | 29324312 |
Congenital heart valve disorder | 14.32 | 10.91 | 8 | 250153 | 54 | 29324312 |
Blood potassium increased | 14.28 | 10.91 | 188 | 249973 | 14463 | 29309903 |
Muscle necrosis | 14.24 | 10.91 | 25 | 250136 | 784 | 29323582 |
Cystitis haemorrhagic | 14.23 | 10.91 | 12 | 250149 | 4830 | 29319536 |
Left atrial enlargement | 14.21 | 10.91 | 24 | 250137 | 729 | 29323637 |
Platelet count decreased | 14.18 | 10.91 | 732 | 249429 | 103940 | 29220426 |
Gamma-glutamyltransferase increased | 14.17 | 10.91 | 151 | 250010 | 26586 | 29297780 |
Penis injury | 14.16 | 10.91 | 14 | 250147 | 245 | 29324121 |
Miosis | 14.14 | 10.91 | 29 | 250132 | 7980 | 29316386 |
Euphoric mood | 14.13 | 10.91 | 12 | 250149 | 4813 | 29319553 |
Neonatal respiratory failure | 14.07 | 10.91 | 16 | 250145 | 331 | 29324035 |
Disease recurrence | 14.05 | 10.91 | 78 | 250083 | 15836 | 29308530 |
Chest discomfort | 14.05 | 10.91 | 498 | 249663 | 45485 | 29278881 |
Nocardiosis | 14.04 | 10.91 | 5 | 250156 | 3255 | 29321111 |
Graft versus host disease in gastrointestinal tract | 14.03 | 10.91 | 5 | 250156 | 3253 | 29321113 |
Autoimmune myocarditis | 14.01 | 10.91 | 12 | 250149 | 173 | 29324193 |
Tricuspid valve incompetence | 13.98 | 10.91 | 120 | 250041 | 8274 | 29316092 |
Biopsy lymph gland | 13.97 | 10.91 | 8 | 250153 | 57 | 29324309 |
Intracranial pressure increased | 13.93 | 10.91 | 6 | 250155 | 3479 | 29320887 |
Withdrawal syndrome | 13.92 | 10.91 | 47 | 250114 | 10945 | 29313421 |
Condition aggravated | 13.92 | 10.91 | 1057 | 249104 | 145238 | 29179128 |
Lymphoma | 13.87 | 10.91 | 40 | 250121 | 9788 | 29314578 |
Urinary tract obstruction | 13.86 | 10.91 | 60 | 250101 | 3237 | 29321129 |
Penile haemorrhage | 13.79 | 10.91 | 21 | 250140 | 583 | 29323783 |
Electrocardiogram QRS complex prolonged | 13.76 | 10.91 | 70 | 250091 | 4040 | 29320326 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 13.75 | 10.91 | 23 | 250138 | 693 | 29323673 |
Generalised tonic-clonic seizure | 13.72 | 10.91 | 100 | 250061 | 19039 | 29305327 |
Spinal epidural haemorrhage | 13.62 | 10.91 | 7 | 250154 | 39 | 29324327 |
Cardiac pacemaker insertion | 13.56 | 10.91 | 49 | 250112 | 2430 | 29321936 |
End stage renal disease | 13.53 | 10.91 | 111 | 250050 | 7553 | 29316813 |
White blood cell count decreased | 13.48 | 10.91 | 572 | 249589 | 82790 | 29241576 |
Oral candidiasis | 13.47 | 10.91 | 46 | 250115 | 10676 | 29313690 |
Disease progression | 13.47 | 10.91 | 561 | 249600 | 81355 | 29243011 |
Affect lability | 13.37 | 10.91 | 6 | 250155 | 3396 | 29320970 |
Portal fibrosis | 13.35 | 10.91 | 15 | 250146 | 306 | 29324060 |
Priapism | 13.34 | 10.91 | 11 | 250150 | 4477 | 29319889 |
Pseudomonas infection | 13.34 | 10.91 | 47 | 250114 | 10805 | 29313561 |
Herpes simplex | 13.32 | 10.91 | 13 | 250148 | 4877 | 29319489 |
Aplasia | 13.31 | 10.91 | 9 | 250152 | 4054 | 29320312 |
Bronchiectasis | 13.27 | 10.91 | 22 | 250139 | 6563 | 29317803 |
Diverticulum intestinal haemorrhagic | 13.24 | 10.91 | 43 | 250118 | 2019 | 29322347 |
Precancerous skin lesion | 13.22 | 10.91 | 20 | 250141 | 552 | 29323814 |
Central nervous system lesion | 13.21 | 10.91 | 17 | 250144 | 5631 | 29318735 |
Inspiratory capacity abnormal | 13.21 | 10.91 | 9 | 250152 | 90 | 29324276 |
Aortic valve incompetence | 13.19 | 10.91 | 80 | 250081 | 4933 | 29319433 |
Kidney rupture | 13.15 | 10.91 | 12 | 250149 | 189 | 29324177 |
High density lipoprotein decreased | 13.13 | 10.91 | 55 | 250106 | 2924 | 29321442 |
Iliac artery stenosis | 13.11 | 10.91 | 8 | 250153 | 65 | 29324301 |
Ventricular arrhythmia | 13.10 | 10.91 | 75 | 250086 | 4529 | 29319837 |
Device related infection | 13.08 | 10.91 | 78 | 250083 | 15558 | 29308808 |
Posterior reversible encephalopathy syndrome | 13.06 | 10.91 | 36 | 250125 | 8940 | 29315426 |
Jaundice | 13.01 | 10.91 | 172 | 249989 | 29124 | 29295242 |
Diverticulum | 13.01 | 10.91 | 95 | 250066 | 6237 | 29318129 |
Loss of personal independence in daily activities | 12.96 | 10.91 | 145 | 250016 | 25295 | 29299071 |
Secretion discharge | 12.91 | 10.91 | 10 | 250151 | 4200 | 29320166 |
Glomerular filtration rate decreased | 12.90 | 10.91 | 149 | 250012 | 11117 | 29313249 |
Increased tendency to bruise | 12.87 | 10.91 | 62 | 250099 | 3500 | 29320866 |
Idiopathic pulmonary fibrosis | 12.82 | 10.91 | 57 | 250104 | 3111 | 29321255 |
Increased viscosity of bronchial secretion | 12.80 | 10.91 | 12 | 250149 | 196 | 29324170 |
Systemic infection | 12.77 | 10.91 | 43 | 250118 | 2058 | 29322308 |
No adverse event | 12.69 | 10.91 | 91 | 250070 | 17387 | 29306979 |
Apallic syndrome | 12.68 | 10.91 | 13 | 250148 | 238 | 29324128 |
Facial asymmetry | 12.64 | 10.91 | 14 | 250147 | 281 | 29324085 |
Acoustic stimulation tests abnormal | 12.62 | 10.91 | 8 | 250153 | 70 | 29324296 |
Heart valve incompetence | 12.61 | 10.91 | 30 | 250131 | 1173 | 29323193 |
Neonatal tachycardia | 12.61 | 10.91 | 5 | 250156 | 13 | 29324353 |
Torsade de pointes | 12.59 | 10.91 | 98 | 250063 | 6563 | 29317803 |
Pulmonary valve stenosis congenital | 12.58 | 10.91 | 10 | 250151 | 129 | 29324237 |
Venoocclusive disease | 12.57 | 10.91 | 3 | 250158 | 2536 | 29321830 |
Arteriosclerotic gangrene | 12.53 | 10.91 | 8 | 250153 | 71 | 29324295 |
Blood alkaline phosphatase abnormal | 12.50 | 10.91 | 16 | 250145 | 376 | 29323990 |
Cardiogenic shock | 12.49 | 10.91 | 230 | 249931 | 18960 | 29305406 |
Ageusia | 12.47 | 10.91 | 123 | 250038 | 8815 | 29315551 |
Dermatitis exfoliative | 12.45 | 10.91 | 22 | 250139 | 6403 | 29317963 |
Chromaturia | 12.37 | 10.91 | 164 | 249997 | 12638 | 29311728 |
Dermatitis acneiform | 12.36 | 10.91 | 17 | 250144 | 5474 | 29318892 |
Parathyroid hormone-related protein abnormal | 12.35 | 10.91 | 5 | 250156 | 14 | 29324352 |
Coma scale abnormal | 12.31 | 10.91 | 7 | 250154 | 3462 | 29320904 |
Parkinsonism | 12.31 | 10.91 | 27 | 250134 | 7251 | 29317115 |
Folliculitis | 12.30 | 10.91 | 9 | 250152 | 3891 | 29320475 |
Low cardiac output syndrome | 12.27 | 10.91 | 18 | 250143 | 483 | 29323883 |
Blue toe syndrome | 12.21 | 10.91 | 10 | 250151 | 135 | 29324231 |
Cardiac function test abnormal | 12.19 | 10.91 | 6 | 250155 | 30 | 29324336 |
Neurotoxicity | 12.17 | 10.91 | 73 | 250088 | 14540 | 29309826 |
Vascular stent thrombosis | 12.15 | 10.91 | 49 | 250112 | 2561 | 29321805 |
Orthopnoea | 12.14 | 10.91 | 73 | 250088 | 4487 | 29319879 |
Vasoplegia syndrome | 12.09 | 10.91 | 34 | 250127 | 1474 | 29322892 |
Eczema | 12.08 | 10.91 | 68 | 250093 | 13758 | 29310608 |
Aortic aneurysm | 12.03 | 10.91 | 92 | 250069 | 6128 | 29318238 |
Upper gastrointestinal haemorrhage | 12.03 | 10.91 | 256 | 249905 | 21658 | 29302708 |
Pulse pressure decreased | 12.02 | 10.91 | 11 | 250150 | 174 | 29324192 |
Product solubility abnormal | 11.99 | 10.91 | 17 | 250144 | 442 | 29323924 |
Implantable defibrillator insertion | 11.97 | 10.91 | 21 | 250140 | 658 | 29323708 |
Paronychia | 11.94 | 10.91 | 5 | 250156 | 2948 | 29321418 |
Stevens-Johnson syndrome | 11.92 | 10.91 | 86 | 250075 | 16411 | 29307955 |
Aortic valve sclerosis | 11.91 | 10.91 | 23 | 250138 | 777 | 29323589 |
Alcohol interaction | 11.89 | 10.91 | 4 | 250157 | 2699 | 29321667 |
Lymphomatoid papulosis | 11.87 | 10.91 | 11 | 250150 | 177 | 29324189 |
Mitral valve prolapse | 11.83 | 10.91 | 19 | 250142 | 553 | 29323813 |
Hyperthyroidism | 11.79 | 10.91 | 118 | 250043 | 8490 | 29315876 |
Carcinoid tumour of the gastrointestinal tract | 11.77 | 10.91 | 7 | 250154 | 54 | 29324312 |
Blood cholinesterase decreased | 11.72 | 10.91 | 9 | 250152 | 110 | 29324256 |
Balance disorder | 11.62 | 10.91 | 394 | 249767 | 35776 | 29288590 |
Thoracic haemorrhage | 11.62 | 10.91 | 11 | 250150 | 182 | 29324184 |
Musculoskeletal pain | 11.60 | 10.91 | 324 | 249837 | 28629 | 29295737 |
Encephalitis | 11.60 | 10.91 | 23 | 250138 | 6407 | 29317959 |
Lymphadenopathy | 11.52 | 10.91 | 146 | 250015 | 24903 | 29299463 |
Bradyarrhythmia | 11.51 | 10.91 | 40 | 250121 | 1945 | 29322421 |
Dystonia | 11.47 | 10.91 | 43 | 250118 | 9706 | 29314660 |
Cardiovascular somatic symptom disorder | 11.45 | 10.91 | 6 | 250155 | 35 | 29324331 |
Hepatic encephalopathy | 11.45 | 10.91 | 64 | 250097 | 12971 | 29311395 |
Post transplant lymphoproliferative disorder | 11.40 | 10.91 | 18 | 250143 | 5475 | 29318891 |
Acute lymphocytic leukaemia | 11.39 | 10.91 | 4 | 250157 | 2627 | 29321739 |
Oxygen saturation decreased | 11.39 | 10.91 | 291 | 249870 | 44646 | 29279720 |
Pulmonary fibrosis | 11.37 | 10.91 | 81 | 250080 | 15501 | 29308865 |
Therapeutic response decreased | 11.37 | 10.91 | 144 | 250017 | 24567 | 29299799 |
Venous pressure jugular abnormal | 11.34 | 10.91 | 3 | 250158 | 0 | 29324366 |
Paraganglion neoplasm | 11.34 | 10.91 | 3 | 250158 | 0 | 29324366 |
Myofascial spasm | 11.34 | 10.91 | 3 | 250158 | 0 | 29324366 |
Non-small cell lung cancer stage IIIA | 11.34 | 10.91 | 3 | 250158 | 0 | 29324366 |
Blood bilirubin increased | 11.33 | 10.91 | 210 | 249951 | 33683 | 29290683 |
Hepatosplenomegaly | 11.18 | 10.91 | 9 | 250152 | 3708 | 29320658 |
Injection site pain | 11.17 | 10.91 | 200 | 249961 | 32246 | 29292120 |
Atrial tachycardia | 11.16 | 10.91 | 39 | 250122 | 1902 | 29322464 |
Cardioversion | 11.14 | 10.91 | 23 | 250138 | 816 | 29323550 |
Anal abscess | 11.09 | 10.91 | 17 | 250144 | 5234 | 29319132 |
Pyonephrosis | 11.07 | 10.91 | 7 | 250154 | 61 | 29324305 |
Sprue-like enteropathy | 11.06 | 10.91 | 16 | 250145 | 424 | 29323942 |
Organising pneumonia | 11.00 | 10.91 | 16 | 250145 | 5032 | 29319334 |
Histology abnormal | 10.95 | 10.91 | 13 | 250148 | 282 | 29324084 |
Mucosal haemorrhage | 10.95 | 10.91 | 33 | 250128 | 1488 | 29322878 |
Pharyngitis | 10.93 | 10.91 | 27 | 250134 | 6956 | 29317410 |
Haemorrhage | 10.92 | 10.91 | 476 | 249685 | 44596 | 29279770 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myocardial infarction | 2432.25 | 10.03 | 4141 | 427525 | 161680 | 63905386 |
Cardiac failure congestive | 1390.28 | 10.03 | 2844 | 428822 | 127736 | 63939330 |
Coronary artery disease | 1199.51 | 10.03 | 1736 | 429930 | 58697 | 64008369 |
Bradycardia | 1012.14 | 10.03 | 2359 | 429307 | 115860 | 63951206 |
Atrial fibrillation | 1007.78 | 10.03 | 2968 | 428698 | 168121 | 63898945 |
Acute myocardial infarction | 782.42 | 10.03 | 1553 | 430113 | 68165 | 63998901 |
Drug ineffective | 559.56 | 10.03 | 3321 | 428345 | 836926 | 63230140 |
Hypotension | 549.51 | 10.03 | 4391 | 427275 | 376583 | 63690483 |
Off label use | 531.66 | 10.03 | 2306 | 429360 | 630500 | 63436566 |
Product prescribing error | 507.95 | 10.03 | 875 | 430791 | 34394 | 64032672 |
Coronary artery bypass | 491.08 | 10.03 | 365 | 431301 | 5450 | 64061616 |
Synovitis | 489.57 | 10.03 | 48 | 431618 | 99042 | 63968024 |
Syncope | 488.94 | 10.03 | 2221 | 429445 | 155414 | 63911652 |
Cerebrovascular accident | 466.50 | 10.03 | 1991 | 429675 | 135592 | 63931474 |
Completed suicide | 463.06 | 10.03 | 2824 | 428842 | 221590 | 63845476 |
Dizziness | 397.84 | 10.03 | 4513 | 427153 | 425650 | 63641416 |
Hand deformity | 333.40 | 10.03 | 22 | 431644 | 62749 | 64004317 |
Drug intolerance | 325.10 | 10.03 | 471 | 431195 | 187521 | 63879545 |
Infusion related reaction | 323.61 | 10.03 | 374 | 431292 | 164093 | 63902973 |
Pemphigus | 300.86 | 10.03 | 29 | 431637 | 60672 | 64006394 |
Coronary arterial stent insertion | 298.87 | 10.03 | 271 | 431395 | 5421 | 64061645 |
Joint swelling | 295.79 | 10.03 | 624 | 431042 | 214758 | 63852308 |
Systemic lupus erythematosus | 295.67 | 10.03 | 77 | 431589 | 77535 | 63989531 |
Drug abuse | 282.69 | 10.03 | 281 | 431385 | 132093 | 63934973 |
Treatment failure | 280.69 | 10.03 | 222 | 431444 | 116594 | 63950472 |
Dyspnoea | 280.44 | 10.03 | 6532 | 425134 | 712142 | 63354924 |
Angina unstable | 270.46 | 10.03 | 419 | 431247 | 15048 | 64052018 |
Lower respiratory tract infection | 270.36 | 10.03 | 148 | 431518 | 94466 | 63972600 |
Arthropathy | 258.05 | 10.03 | 257 | 431409 | 120710 | 63946356 |
Rheumatoid arthritis | 257.99 | 10.03 | 439 | 431227 | 163855 | 63903211 |
General physical health deterioration | 241.38 | 10.03 | 2256 | 429410 | 202169 | 63864897 |
Fall | 238.34 | 10.03 | 4015 | 427651 | 412811 | 63654255 |
Angina pectoris | 235.81 | 10.03 | 751 | 430915 | 44330 | 64022736 |
Gastrointestinal haemorrhage | 227.93 | 10.03 | 1592 | 430074 | 130720 | 63936346 |
Cardiac disorder | 227.62 | 10.03 | 856 | 430810 | 54960 | 64012106 |
Haematochezia | 219.72 | 10.03 | 954 | 430712 | 65419 | 64001647 |
Therapeutic product effect decreased | 218.64 | 10.03 | 270 | 431396 | 115081 | 63951985 |
Rheumatoid factor positive | 213.62 | 10.03 | 4 | 431662 | 34934 | 64032132 |
Glossodynia | 211.38 | 10.03 | 84 | 431582 | 64612 | 64002454 |
Contraindicated product administered | 210.10 | 10.03 | 247 | 431419 | 107582 | 63959484 |
Pericarditis | 204.53 | 10.03 | 81 | 431585 | 62435 | 64004631 |
Febrile neutropenia | 198.73 | 10.03 | 620 | 431046 | 187037 | 63880029 |
Hypersensitivity | 194.94 | 10.03 | 668 | 430998 | 195784 | 63871282 |
Pyrexia | 191.85 | 10.03 | 2611 | 429055 | 556033 | 63511033 |
Neutropenia | 190.82 | 10.03 | 889 | 430777 | 238735 | 63828331 |
Duodenal ulcer perforation | 187.26 | 10.03 | 11 | 431655 | 34614 | 64032452 |
Product monitoring error | 185.29 | 10.03 | 205 | 431461 | 5249 | 64061817 |
Helicobacter infection | 175.93 | 10.03 | 24 | 431642 | 38338 | 64028728 |
Ventricular tachycardia | 173.91 | 10.03 | 565 | 431101 | 33700 | 64033366 |
International normalised ratio increased | 172.34 | 10.03 | 1011 | 430655 | 78156 | 63988910 |
Sinus bradycardia | 172.23 | 10.03 | 435 | 431231 | 22458 | 64044608 |
Asthenia | 171.32 | 10.03 | 3907 | 427759 | 424137 | 63642929 |
Chest pain | 168.36 | 10.03 | 2361 | 429305 | 233619 | 63833447 |
Rash | 159.13 | 10.03 | 2138 | 429528 | 456411 | 63610655 |
Drug hypersensitivity | 158.67 | 10.03 | 937 | 430729 | 236878 | 63830188 |
Product use in unapproved indication | 155.95 | 10.03 | 630 | 431036 | 175988 | 63891078 |
Arthralgia | 155.65 | 10.03 | 2056 | 429610 | 440204 | 63626862 |
Maternal exposure during pregnancy | 150.63 | 10.03 | 256 | 431410 | 95628 | 63971438 |
Arrhythmia | 149.98 | 10.03 | 727 | 430939 | 52217 | 64014849 |
Drug reaction with eosinophilia and systemic symptoms | 148.86 | 10.03 | 89 | 431577 | 54128 | 64012938 |
Cardiac arrest | 147.53 | 10.03 | 1629 | 430037 | 152435 | 63914631 |
Folliculitis | 142.32 | 10.03 | 17 | 431649 | 30060 | 64037006 |
Dehydration | 137.39 | 10.03 | 2125 | 429541 | 214638 | 63852428 |
Product use issue | 135.29 | 10.03 | 539 | 431127 | 151176 | 63915890 |
Swelling | 133.09 | 10.03 | 585 | 431081 | 159633 | 63907433 |
Sinusitis | 131.67 | 10.03 | 516 | 431150 | 145412 | 63921654 |
Muscle injury | 130.02 | 10.03 | 13 | 431653 | 26424 | 64040642 |
Palpitations | 128.14 | 10.03 | 1163 | 430503 | 103325 | 63963741 |
Cardiogenic shock | 126.17 | 10.03 | 490 | 431176 | 31937 | 64035129 |
Hepatic enzyme increased | 124.04 | 10.03 | 449 | 431217 | 129494 | 63937572 |
C-reactive protein abnormal | 122.34 | 10.03 | 23 | 431643 | 29024 | 64038042 |
Renal failure | 121.23 | 10.03 | 1797 | 429869 | 179891 | 63887175 |
Atrial flutter | 119.35 | 10.03 | 342 | 431324 | 19038 | 64048028 |
Hepatic function abnormal | 119.26 | 10.03 | 153 | 431513 | 64160 | 64002906 |
Suspected suicide | 118.44 | 10.03 | 210 | 431456 | 8444 | 64058622 |
Alopecia | 116.83 | 10.03 | 641 | 431025 | 165049 | 63902017 |
Vascular graft | 116.71 | 10.03 | 98 | 431568 | 1761 | 64065305 |
Hypertensive emergency | 112.95 | 10.03 | 105 | 431561 | 2171 | 64064895 |
Oedema peripheral | 112.31 | 10.03 | 2005 | 429661 | 208312 | 63858754 |
Irritable bowel syndrome | 110.34 | 10.03 | 56 | 431610 | 37313 | 64029753 |
Interstitial lung disease | 108.33 | 10.03 | 316 | 431350 | 97416 | 63969650 |
Sleep disorder due to general medical condition, insomnia type | 108.12 | 10.03 | 22 | 431644 | 26248 | 64040818 |
Myocardial ischaemia | 107.88 | 10.03 | 372 | 431294 | 22879 | 64044187 |
Acute coronary syndrome | 107.71 | 10.03 | 329 | 431337 | 18981 | 64048085 |
Labelled drug-drug interaction medication error | 104.13 | 10.03 | 355 | 431311 | 21707 | 64045359 |
Blood loss anaemia | 101.41 | 10.03 | 261 | 431405 | 13631 | 64053435 |
Coronary artery occlusion | 96.31 | 10.03 | 256 | 431410 | 13635 | 64053431 |
Drug resistance | 95.83 | 10.03 | 58 | 431608 | 35044 | 64032022 |
Infection | 94.92 | 10.03 | 786 | 430880 | 184094 | 63882972 |
Death | 93.72 | 10.03 | 4036 | 427630 | 478669 | 63588397 |
Mucosal inflammation | 90.32 | 10.03 | 176 | 431490 | 62408 | 64004658 |
Musculoskeletal stiffness | 88.84 | 10.03 | 473 | 431193 | 122733 | 63944333 |
C-reactive protein increased | 88.55 | 10.03 | 331 | 431335 | 94578 | 63972488 |
Discomfort | 88.54 | 10.03 | 263 | 431403 | 80615 | 63986451 |
Exposure during pregnancy | 88.39 | 10.03 | 248 | 431418 | 77427 | 63989639 |
Sopor | 88.25 | 10.03 | 44 | 431622 | 29617 | 64037449 |
Cardiac failure | 88.15 | 10.03 | 1309 | 430357 | 131064 | 63936002 |
Pregnancy | 86.86 | 10.03 | 17 | 431649 | 20848 | 64046218 |
Pain | 85.39 | 10.03 | 2941 | 428725 | 550570 | 63516496 |
Bone marrow failure | 83.91 | 10.03 | 119 | 431547 | 47833 | 64019233 |
Drug interaction | 82.63 | 10.03 | 3081 | 428585 | 359002 | 63708064 |
Neutrophil count decreased | 82.38 | 10.03 | 254 | 431412 | 76942 | 63990124 |
Medication error | 82.33 | 10.03 | 595 | 431071 | 49371 | 64017695 |
Rhabdomyolysis | 81.48 | 10.03 | 956 | 430710 | 90770 | 63976296 |
Red blood cell sedimentation rate abnormal | 80.24 | 10.03 | 8 | 431658 | 16298 | 64050768 |
Blood creatinine increased | 79.87 | 10.03 | 1315 | 430351 | 134467 | 63932599 |
Renal injury | 79.72 | 10.03 | 256 | 431410 | 15173 | 64051893 |
Nasopharyngitis | 79.24 | 10.03 | 884 | 430782 | 195189 | 63871877 |
Hepatocellular injury | 78.42 | 10.03 | 113 | 431553 | 45122 | 64021944 |
Therapeutic drug monitoring analysis not performed | 78.39 | 10.03 | 65 | 431601 | 1147 | 64065919 |
Blister | 77.75 | 10.03 | 279 | 431387 | 80688 | 63986378 |
Erythema | 77.35 | 10.03 | 839 | 430827 | 186231 | 63880835 |
Atrioventricular block | 76.88 | 10.03 | 215 | 431451 | 11800 | 64055266 |
Suicidal ideation | 76.79 | 10.03 | 211 | 431455 | 66331 | 64000735 |
Abortion spontaneous | 76.78 | 10.03 | 36 | 431630 | 25107 | 64041959 |
Atrioventricular block complete | 76.11 | 10.03 | 241 | 431425 | 14177 | 64052889 |
BRASH syndrome | 75.84 | 10.03 | 41 | 431625 | 336 | 64066730 |
Coronary artery stenosis | 74.67 | 10.03 | 204 | 431462 | 11044 | 64056022 |
Hypertensive crisis | 72.83 | 10.03 | 278 | 431388 | 17970 | 64049096 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 72.79 | 10.03 | 94 | 431572 | 2842 | 64064224 |
Headache | 71.39 | 10.03 | 2859 | 428807 | 526608 | 63540458 |
Transient ischaemic attack | 71.00 | 10.03 | 523 | 431143 | 43659 | 64023407 |
Asthma | 70.08 | 10.03 | 363 | 431303 | 94862 | 63972204 |
Hyperkalaemia | 70.05 | 10.03 | 1007 | 430659 | 100122 | 63966944 |
Presyncope | 69.90 | 10.03 | 438 | 431228 | 34651 | 64032415 |
Migraine | 69.19 | 10.03 | 203 | 431463 | 62474 | 64004592 |
Drug eruption | 69.05 | 10.03 | 84 | 431582 | 36052 | 64031014 |
Gastrointestinal disorder | 68.85 | 10.03 | 337 | 431329 | 89372 | 63977694 |
Hepatic cytolysis | 68.85 | 10.03 | 7 | 431659 | 14042 | 64053024 |
Intentional product use issue | 68.80 | 10.03 | 366 | 431300 | 94998 | 63972068 |
Stomatitis | 68.76 | 10.03 | 440 | 431226 | 109165 | 63957901 |
Urticaria | 68.23 | 10.03 | 643 | 431023 | 146674 | 63920392 |
Nodal rhythm | 68.12 | 10.03 | 90 | 431576 | 2784 | 64064282 |
Eosinophilia | 68.12 | 10.03 | 93 | 431573 | 37983 | 64029083 |
Cytomegalovirus infection | 67.42 | 10.03 | 90 | 431576 | 37109 | 64029957 |
Dyspnoea exertional | 65.72 | 10.03 | 769 | 430897 | 72961 | 63994105 |
Haemoglobin decreased | 65.05 | 10.03 | 1738 | 429928 | 193325 | 63873741 |
Mitral valve incompetence | 64.79 | 10.03 | 340 | 431326 | 25198 | 64041868 |
Haematoma | 64.63 | 10.03 | 530 | 431136 | 45720 | 64021346 |
Mental status changes | 63.74 | 10.03 | 658 | 431008 | 60504 | 64006562 |
Febrile bone marrow aplasia | 62.66 | 10.03 | 3 | 431663 | 11252 | 64055814 |
Rash maculo-papular | 62.17 | 10.03 | 139 | 431527 | 46887 | 64020179 |
Pneumocystis jirovecii pneumonia | 62.06 | 10.03 | 56 | 431610 | 27578 | 64039488 |
Pulmonary renal syndrome | 61.97 | 10.03 | 42 | 431624 | 537 | 64066529 |
Chronic kidney disease | 61.26 | 10.03 | 625 | 431041 | 57294 | 64009772 |
Device expulsion | 60.44 | 10.03 | 33 | 431633 | 21103 | 64045963 |
Nodal arrhythmia | 60.42 | 10.03 | 68 | 431598 | 1775 | 64065291 |
Ventricular fibrillation | 60.08 | 10.03 | 317 | 431349 | 23543 | 64043523 |
Orthostatic intolerance | 59.36 | 10.03 | 63 | 431603 | 1537 | 64065529 |
Lower gastrointestinal haemorrhage | 58.66 | 10.03 | 216 | 431450 | 13723 | 64053343 |
Pruritus | 58.27 | 10.03 | 1618 | 430048 | 310782 | 63756284 |
Abdominal discomfort | 58.10 | 10.03 | 864 | 430802 | 181458 | 63885608 |
Pulmonary oedema | 57.95 | 10.03 | 792 | 430874 | 77882 | 63989184 |
Acute generalised exanthematous pustulosis | 57.38 | 10.03 | 12 | 431654 | 14046 | 64053020 |
Injection site pain | 55.63 | 10.03 | 477 | 431189 | 110931 | 63956135 |
Pathogen resistance | 54.86 | 10.03 | 9 | 431657 | 12534 | 64054532 |
Anhedonia | 54.86 | 10.03 | 209 | 431457 | 13497 | 64053569 |
Unresponsive to stimuli | 54.35 | 10.03 | 546 | 431120 | 49847 | 64017219 |
Progressive multifocal leukoencephalopathy | 54.31 | 10.03 | 27 | 431639 | 18205 | 64048861 |
Anaemia | 54.10 | 10.03 | 3074 | 428592 | 375606 | 63691460 |
Haemophagocytic lymphohistiocytosis | 54.10 | 10.03 | 25 | 431641 | 17584 | 64049482 |
Ejection fraction | 53.78 | 10.03 | 54 | 431612 | 1232 | 64065834 |
Pallor | 53.43 | 10.03 | 443 | 431223 | 38338 | 64028728 |
Ischaemic stroke | 52.68 | 10.03 | 354 | 431312 | 28681 | 64038385 |
Toxic skin eruption | 52.45 | 10.03 | 32 | 431634 | 19252 | 64047814 |
Anaphylactic reaction | 52.08 | 10.03 | 259 | 431407 | 68405 | 63998661 |
Septic shock | 51.94 | 10.03 | 453 | 431213 | 104984 | 63962082 |
Haemorrhage intracranial | 51.93 | 10.03 | 305 | 431361 | 23579 | 64043487 |
Arteriosclerosis | 51.59 | 10.03 | 227 | 431439 | 15650 | 64051416 |
Fear | 51.48 | 10.03 | 269 | 431397 | 19902 | 64047164 |
Bone erosion | 51.43 | 10.03 | 8 | 431658 | 11587 | 64055479 |
Red blood cell sedimentation rate increased | 51.27 | 10.03 | 81 | 431585 | 31154 | 64035912 |
Rheumatoid nodule | 51.23 | 10.03 | 11 | 431655 | 12640 | 64054426 |
Blood pressure inadequately controlled | 51.06 | 10.03 | 112 | 431554 | 5272 | 64061794 |
Lymphopenia | 50.78 | 10.03 | 58 | 431608 | 25599 | 64041467 |
Cholestasis | 50.50 | 10.03 | 144 | 431522 | 44728 | 64022338 |
Inflammation | 50.28 | 10.03 | 245 | 431421 | 65055 | 64002011 |
Atrioventricular block first degree | 50.02 | 10.03 | 172 | 431494 | 10562 | 64056504 |
Therapeutic product effect incomplete | 49.48 | 10.03 | 448 | 431218 | 103034 | 63964032 |
Cerebral haemorrhage | 49.20 | 10.03 | 541 | 431125 | 50549 | 64016517 |
Ill-defined disorder | 49.11 | 10.03 | 142 | 431524 | 43910 | 64023156 |
Myxoedema coma | 48.98 | 10.03 | 39 | 431627 | 648 | 64066418 |
Peripheral arterial occlusive disease | 48.67 | 10.03 | 129 | 431537 | 6858 | 64060208 |
Acute kidney injury | 48.59 | 10.03 | 3561 | 428105 | 445679 | 63621387 |
Liver disorder | 48.50 | 10.03 | 188 | 431478 | 53163 | 64013903 |
Atrial thrombosis | 48.48 | 10.03 | 79 | 431587 | 2963 | 64064103 |
Infective pulmonary exacerbation of cystic fibrosis | 48.29 | 10.03 | 10 | 431656 | 11786 | 64055280 |
Mobility decreased | 48.18 | 10.03 | 356 | 431310 | 85484 | 63981582 |
Myelosuppression | 48.11 | 10.03 | 53 | 431613 | 23777 | 64043289 |
Haematotoxicity | 46.85 | 10.03 | 14 | 431652 | 12882 | 64054184 |
Blood pressure increased | 46.45 | 10.03 | 1497 | 430169 | 171055 | 63896011 |
Immune reconstitution inflammatory syndrome | 46.29 | 10.03 | 13 | 431653 | 12457 | 64054609 |
Gout | 45.63 | 10.03 | 272 | 431394 | 21141 | 64045925 |
Injection site erythema | 45.53 | 10.03 | 282 | 431384 | 70518 | 63996548 |
Coagulopathy | 45.25 | 10.03 | 367 | 431299 | 31553 | 64035513 |
Coma | 45.14 | 10.03 | 372 | 431294 | 87243 | 63979823 |
Hyperthermia | 44.87 | 10.03 | 24 | 431642 | 15526 | 64051540 |
Aortic stenosis | 44.83 | 10.03 | 118 | 431548 | 6247 | 64060819 |
Blood glucose increased | 44.75 | 10.03 | 913 | 430753 | 97160 | 63969906 |
Arteriosclerosis coronary artery | 44.51 | 10.03 | 214 | 431452 | 15315 | 64051751 |
Sinus node dysfunction | 44.49 | 10.03 | 123 | 431543 | 6705 | 64060361 |
Tendonitis | 44.48 | 10.03 | 42 | 431624 | 20240 | 64046826 |
Acute graft versus host disease | 43.31 | 10.03 | 5 | 431661 | 9079 | 64057987 |
Hypoglycaemia | 43.07 | 10.03 | 843 | 430823 | 89049 | 63978017 |
Plasma cell myeloma | 43.04 | 10.03 | 485 | 431181 | 45590 | 64021476 |
Ventricular extrasystoles | 42.85 | 10.03 | 231 | 431435 | 17298 | 64049768 |
Agranulocytosis | 42.79 | 10.03 | 123 | 431543 | 38106 | 64028960 |
Troponin increased | 42.55 | 10.03 | 210 | 431456 | 15189 | 64051877 |
Sensitisation | 42.26 | 10.03 | 55 | 431611 | 1676 | 64065390 |
Cardiovascular disorder | 42.07 | 10.03 | 214 | 431452 | 15667 | 64051399 |
Ventricular hypokinesia | 42.05 | 10.03 | 131 | 431535 | 7638 | 64059428 |
Sedation | 41.73 | 10.03 | 140 | 431526 | 41322 | 64025744 |
Bronchopulmonary aspergillosis | 41.30 | 10.03 | 40 | 431626 | 19045 | 64048021 |
Haematuria | 40.62 | 10.03 | 599 | 431067 | 59872 | 64007194 |
Neutropenic sepsis | 40.47 | 10.03 | 58 | 431608 | 23214 | 64043852 |
Hip arthroplasty | 40.40 | 10.03 | 50 | 431616 | 21301 | 64045765 |
Internal haemorrhage | 40.32 | 10.03 | 128 | 431538 | 7539 | 64059527 |
Wound | 40.18 | 10.03 | 323 | 431343 | 76154 | 63990912 |
Circulatory collapse | 40.07 | 10.03 | 373 | 431293 | 33359 | 64033707 |
Hyperlipidaemia | 39.82 | 10.03 | 277 | 431389 | 22699 | 64044367 |
Sinus arrest | 39.76 | 10.03 | 73 | 431593 | 3017 | 64064049 |
Condition aggravated | 39.55 | 10.03 | 2063 | 429603 | 370363 | 63696703 |
Torsade de pointes | 39.23 | 10.03 | 224 | 431442 | 17139 | 64049927 |
Mouth ulceration | 38.85 | 10.03 | 101 | 431565 | 32343 | 64034723 |
Ventricular arrhythmia | 38.28 | 10.03 | 123 | 431543 | 7292 | 64059774 |
Aspergillus infection | 38.23 | 10.03 | 32 | 431634 | 16347 | 64050719 |
Heart rate irregular | 38.22 | 10.03 | 314 | 431352 | 27099 | 64039967 |
Pericardial haemorrhage | 38.05 | 10.03 | 85 | 431581 | 4051 | 64063015 |
Panniculitis | 37.46 | 10.03 | 7 | 431659 | 8872 | 64058194 |
Neuroleptic malignant syndrome | 37.19 | 10.03 | 69 | 431597 | 24927 | 64042139 |
Supraventricular tachycardia | 37.03 | 10.03 | 235 | 431431 | 18672 | 64048394 |
Malignant neoplasm progression | 36.94 | 10.03 | 532 | 431134 | 112339 | 63954727 |
Pacemaker generated rhythm | 36.85 | 10.03 | 15 | 431651 | 58 | 64067008 |
Heart rate abnormal | 36.13 | 10.03 | 94 | 431572 | 4941 | 64062125 |
Post procedural haemorrhage | 36.13 | 10.03 | 172 | 431494 | 12259 | 64054807 |
Therapeutic response decreased | 35.60 | 10.03 | 204 | 431462 | 51984 | 64015082 |
Nephrogenic systemic fibrosis | 35.33 | 10.03 | 103 | 431563 | 5789 | 64061277 |
Bundle branch block left | 35.33 | 10.03 | 147 | 431519 | 9887 | 64057179 |
Acute respiratory failure | 35.27 | 10.03 | 499 | 431167 | 49435 | 64017631 |
Heart rate decreased | 35.25 | 10.03 | 541 | 431125 | 54526 | 64012540 |
Anaphylactic shock | 35.11 | 10.03 | 96 | 431570 | 30232 | 64036834 |
Lactic acidosis | 35.07 | 10.03 | 592 | 431074 | 60818 | 64006248 |
Malaise | 35.02 | 10.03 | 2234 | 429432 | 394013 | 63673053 |
Cardiac failure chronic | 34.66 | 10.03 | 136 | 431530 | 8905 | 64058161 |
Unevaluable event | 34.65 | 10.03 | 502 | 431164 | 49987 | 64017079 |
Angioedema | 34.59 | 10.03 | 594 | 431072 | 61227 | 64005839 |
Sedation complication | 34.55 | 10.03 | 13 | 431653 | 10341 | 64056725 |
Bradyarrhythmia | 34.31 | 10.03 | 77 | 431589 | 3681 | 64063385 |
Device interaction | 34.25 | 10.03 | 32 | 431634 | 666 | 64066400 |
Haemorrhage | 34.01 | 10.03 | 732 | 430934 | 78619 | 63988447 |
Unintentional medical device removal | 33.94 | 10.03 | 3 | 431663 | 6731 | 64060335 |
Glomerular filtration rate decreased | 33.94 | 10.03 | 236 | 431430 | 19336 | 64047730 |
Aortic valve incompetence | 33.57 | 10.03 | 127 | 431539 | 8174 | 64058892 |
Psoriatic arthropathy | 33.54 | 10.03 | 162 | 431504 | 43119 | 64023947 |
Gastrointestinal tract mucosal pigmentation | 33.50 | 10.03 | 36 | 431630 | 891 | 64066175 |
Graft versus host disease | 33.47 | 10.03 | 26 | 431640 | 13787 | 64053279 |
Disseminated intravascular coagulation | 33.40 | 10.03 | 108 | 431558 | 32240 | 64034826 |
Cardiac valve disease | 33.27 | 10.03 | 93 | 431573 | 5102 | 64061964 |
Epistaxis | 33.15 | 10.03 | 876 | 430790 | 97255 | 63969811 |
Product administration error | 33.00 | 10.03 | 306 | 431360 | 27337 | 64039729 |
Venoocclusive liver disease | 32.71 | 10.03 | 13 | 431653 | 10002 | 64057064 |
Peripheral vascular disorder | 32.66 | 10.03 | 115 | 431551 | 7146 | 64059920 |
Hypervolaemia | 32.65 | 10.03 | 396 | 431270 | 37889 | 64029177 |
Myocardial depression | 32.58 | 10.03 | 27 | 431639 | 476 | 64066590 |
Thrombocytopenia | 32.57 | 10.03 | 1197 | 430469 | 222604 | 63844462 |
Blood pressure decreased | 32.52 | 10.03 | 781 | 430885 | 85418 | 63981648 |
Orthopnoea | 32.30 | 10.03 | 134 | 431532 | 9000 | 64058066 |
Hepatitis | 32.28 | 10.03 | 176 | 431490 | 45406 | 64021660 |
Cardiac pacemaker insertion | 32.25 | 10.03 | 90 | 431576 | 4933 | 64062133 |
Occult blood positive | 32.19 | 10.03 | 104 | 431562 | 6183 | 64060883 |
Diverticulum intestinal haemorrhagic | 32.14 | 10.03 | 69 | 431597 | 3200 | 64063866 |
Acute graft versus host disease in skin | 32.12 | 10.03 | 4 | 431662 | 6851 | 64060215 |
Tricuspid valve incompetence | 31.86 | 10.03 | 209 | 431457 | 16794 | 64050272 |
Polycystic ovaries | 31.72 | 10.03 | 54 | 431612 | 2101 | 64064965 |
Decorticate posture | 31.58 | 10.03 | 22 | 431644 | 295 | 64066771 |
Toxic epidermal necrolysis | 31.25 | 10.03 | 135 | 431531 | 37031 | 64030035 |
Chronic graft versus host disease | 31.09 | 10.03 | 3 | 431663 | 6273 | 64060793 |
Thrombosis | 31.03 | 10.03 | 654 | 431012 | 69988 | 63997078 |
Epstein-Barr virus infection | 30.91 | 10.03 | 23 | 431643 | 12465 | 64054601 |
Lymphocyte count decreased | 30.58 | 10.03 | 154 | 431512 | 40545 | 64026521 |
Arterial haemorrhage | 30.35 | 10.03 | 54 | 431612 | 2177 | 64064889 |
Impaired healing | 30.14 | 10.03 | 259 | 431407 | 60214 | 64006852 |
Cardioversion | 30.11 | 10.03 | 49 | 431617 | 1836 | 64065230 |
Full blood count decreased | 30.06 | 10.03 | 256 | 431410 | 22326 | 64044740 |
Pulmonary hypertension | 30.03 | 10.03 | 430 | 431236 | 42709 | 64024357 |
Multiple-drug resistance | 29.97 | 10.03 | 4 | 431662 | 6498 | 64060568 |
Blood test abnormal | 29.91 | 10.03 | 168 | 431498 | 12775 | 64054291 |
Granuloma skin | 29.83 | 10.03 | 3 | 431663 | 6071 | 64060995 |
End stage renal disease | 29.77 | 10.03 | 144 | 431522 | 10331 | 64056735 |
Low density lipoprotein abnormal | 29.44 | 10.03 | 21 | 431645 | 293 | 64066773 |
Injection site reaction | 29.42 | 10.03 | 187 | 431479 | 46477 | 64020589 |
Tachyarrhythmia | 29.35 | 10.03 | 98 | 431568 | 5928 | 64061138 |
Blue toe syndrome | 29.33 | 10.03 | 27 | 431639 | 551 | 64066515 |
Therapy partial responder | 29.30 | 10.03 | 16 | 431650 | 10232 | 64056834 |
Fluid retention | 29.23 | 10.03 | 561 | 431105 | 59045 | 64008021 |
Immunodeficiency | 29.23 | 10.03 | 39 | 431627 | 16085 | 64050981 |
Dystonia | 29.03 | 10.03 | 51 | 431615 | 18814 | 64048252 |
Cardiac failure acute | 28.89 | 10.03 | 198 | 431468 | 16146 | 64050920 |
Coronary artery dissection | 28.86 | 10.03 | 33 | 431633 | 877 | 64066189 |
Heart rate increased | 28.63 | 10.03 | 864 | 430802 | 97811 | 63969255 |
Vomiting | 28.54 | 10.03 | 3241 | 428425 | 547876 | 63519190 |
Essential hypertension | 28.50 | 10.03 | 88 | 431578 | 5106 | 64061960 |
Hypertension | 28.45 | 10.03 | 2058 | 429608 | 257203 | 63809863 |
Aggression | 28.26 | 10.03 | 187 | 431479 | 46045 | 64021021 |
Poor venous access | 28.08 | 10.03 | 25 | 431641 | 12392 | 64054674 |
Aphthous ulcer | 27.98 | 10.03 | 27 | 431639 | 12879 | 64054187 |
Pleural effusion | 27.60 | 10.03 | 1072 | 430594 | 125487 | 63941579 |
Knee arthroplasty | 27.28 | 10.03 | 91 | 431575 | 26908 | 64040158 |
Intentional self-injury | 27.27 | 10.03 | 101 | 431565 | 28943 | 64038123 |
Acute lung injury | 27.26 | 10.03 | 58 | 431608 | 2673 | 64064393 |
Ageusia | 27.24 | 10.03 | 172 | 431494 | 13641 | 64053425 |
Ischaemic cardiomyopathy | 27.14 | 10.03 | 104 | 431562 | 6734 | 64060332 |
Pharyngitis | 27.07 | 10.03 | 54 | 431612 | 18985 | 64048081 |
Chronotropic incompetence | 26.74 | 10.03 | 13 | 431653 | 83 | 64066983 |
Tuberculosis | 26.32 | 10.03 | 29 | 431637 | 13009 | 64054057 |
Renal impairment | 26.31 | 10.03 | 1130 | 430536 | 133887 | 63933179 |
Nodule | 26.30 | 10.03 | 50 | 431616 | 17897 | 64049169 |
Acute left ventricular failure | 26.27 | 10.03 | 39 | 431627 | 1348 | 64065718 |
Atrial tachycardia | 26.11 | 10.03 | 67 | 431599 | 3492 | 64063574 |
Pulmonary tuberculosis | 26.07 | 10.03 | 8 | 431658 | 7236 | 64059830 |
Poisoning deliberate | 26.01 | 10.03 | 31 | 431635 | 13427 | 64053639 |
Pancytopenia | 25.96 | 10.03 | 745 | 430921 | 142564 | 63924502 |
Irritability | 25.95 | 10.03 | 142 | 431524 | 36604 | 64030462 |
Uveitis | 25.95 | 10.03 | 28 | 431638 | 12680 | 64054386 |
Melaena | 25.92 | 10.03 | 503 | 431163 | 53045 | 64014021 |
Alanine aminotransferase increased | 25.89 | 10.03 | 720 | 430946 | 138311 | 63928755 |
Device capturing issue | 25.77 | 10.03 | 10 | 431656 | 33 | 64067033 |
Injection site pruritus | 25.72 | 10.03 | 148 | 431518 | 37678 | 64029388 |
Drug dependence | 25.63 | 10.03 | 125 | 431541 | 33187 | 64033879 |
Atrioventricular block second degree | 25.49 | 10.03 | 98 | 431568 | 6356 | 64060710 |
Electrocardiogram T wave abnormal | 25.48 | 10.03 | 64 | 431602 | 3292 | 64063774 |
Cardiac output decreased | 25.48 | 10.03 | 43 | 431623 | 1661 | 64065405 |
Electrocardiogram abnormal | 25.44 | 10.03 | 166 | 431500 | 13315 | 64053751 |
Seizure | 25.32 | 10.03 | 888 | 430778 | 166004 | 63901062 |
Weight increased | 25.31 | 10.03 | 1168 | 430498 | 212180 | 63854886 |
Upper gastrointestinal haemorrhage | 25.29 | 10.03 | 353 | 431313 | 34867 | 64032199 |
Ovarian cyst | 25.13 | 10.03 | 22 | 431644 | 10996 | 64056070 |
Cystitis haemorrhagic | 24.90 | 10.03 | 11 | 431655 | 7945 | 64059121 |
Chromaturia | 24.87 | 10.03 | 246 | 431420 | 22365 | 64044701 |
Bronchiectasis | 24.83 | 10.03 | 35 | 431631 | 14105 | 64052961 |
Live birth | 24.81 | 10.03 | 23 | 431643 | 11181 | 64055885 |
Hip fracture | 24.74 | 10.03 | 284 | 431382 | 26815 | 64040251 |
Product quality issue | 24.45 | 10.03 | 306 | 431360 | 29493 | 64037573 |
Hiatus hernia | 24.37 | 10.03 | 222 | 431444 | 19735 | 64047331 |
Vascular stent thrombosis | 24.34 | 10.03 | 63 | 431603 | 3301 | 64063765 |
Idiopathic pulmonary fibrosis | 24.31 | 10.03 | 68 | 431598 | 3732 | 64063334 |
Product solubility abnormal | 24.23 | 10.03 | 29 | 431637 | 810 | 64066256 |
Hypogammaglobulinaemia | 24.18 | 10.03 | 20 | 431646 | 10279 | 64056787 |
Cardiomyopathy | 24.18 | 10.03 | 268 | 431398 | 25088 | 64041978 |
Degenerative aortic valve disease | 24.10 | 10.03 | 13 | 431653 | 106 | 64066960 |
Stent placement | 24.01 | 10.03 | 87 | 431579 | 5484 | 64061582 |
Epilepsy | 24.00 | 10.03 | 129 | 431537 | 33402 | 64033664 |
Body tinea | 23.97 | 10.03 | 36 | 431630 | 1257 | 64065809 |
Forced expiratory volume decreased | 23.97 | 10.03 | 8 | 431658 | 6859 | 64060207 |
Lung disorder | 23.96 | 10.03 | 275 | 431391 | 60425 | 64006641 |
Thrombotic microangiopathy | 23.88 | 10.03 | 47 | 431619 | 16608 | 64050458 |
Aortic valve sclerosis | 23.81 | 10.03 | 40 | 431626 | 1539 | 64065527 |
Blood albumin abnormal | 23.78 | 10.03 | 25 | 431641 | 603 | 64066463 |
Cardiac operation | 23.69 | 10.03 | 72 | 431594 | 4142 | 64062924 |
Hypovolaemia | 23.57 | 10.03 | 181 | 431485 | 15305 | 64051761 |
Serotonin syndrome | 23.46 | 10.03 | 160 | 431506 | 39122 | 64027944 |
Blood parathyroid hormone decreased | 23.35 | 10.03 | 10 | 431656 | 7356 | 64059710 |
Foot deformity | 23.30 | 10.03 | 47 | 431619 | 16457 | 64050609 |
Abnormal behaviour | 23.16 | 10.03 | 131 | 431535 | 33491 | 64033575 |
Substance abuse | 23.14 | 10.03 | 17 | 431649 | 9275 | 64057791 |
Post transplant lymphoproliferative disorder | 23.08 | 10.03 | 18 | 431648 | 9526 | 64057540 |
Cardiac ablation | 22.97 | 10.03 | 42 | 431624 | 1730 | 64065336 |
International normalised ratio decreased | 22.86 | 10.03 | 105 | 431561 | 7373 | 64059693 |
Pneumonia aspiration | 22.83 | 10.03 | 270 | 431396 | 59001 | 64008065 |
Electrocardiogram RR interval prolonged | 22.81 | 10.03 | 7 | 431659 | 8 | 64067058 |
Erythema multiforme | 22.78 | 10.03 | 44 | 431622 | 15657 | 64051409 |
Generalised tonic-clonic seizure | 22.50 | 10.03 | 165 | 431501 | 39692 | 64027374 |
Graft versus host disease in gastrointestinal tract | 22.48 | 10.03 | 5 | 431661 | 5607 | 64061459 |
Therapy non-responder | 22.48 | 10.03 | 308 | 431358 | 65591 | 64001475 |
Cardiomegaly | 22.43 | 10.03 | 250 | 431416 | 23434 | 64043632 |
Device dislocation | 22.36 | 10.03 | 70 | 431596 | 21108 | 64045958 |
Penis injury | 22.30 | 10.03 | 13 | 431653 | 125 | 64066941 |
Hepatitis B | 22.28 | 10.03 | 12 | 431654 | 7733 | 64059333 |
Blood potassium increased | 22.27 | 10.03 | 269 | 431397 | 25711 | 64041355 |
Diffuse large B-cell lymphoma | 22.09 | 10.03 | 22 | 431644 | 10339 | 64056727 |
Rectal haemorrhage | 22.09 | 10.03 | 556 | 431110 | 61261 | 64005805 |
Fracture | 22.08 | 10.03 | 207 | 431459 | 18548 | 64048518 |
Device adhesion issue | 22.07 | 10.03 | 4 | 431662 | 5182 | 64061884 |
Agitation | 21.91 | 10.03 | 438 | 431228 | 87929 | 63979137 |
Status epilepticus | 21.90 | 10.03 | 73 | 431593 | 21590 | 64045476 |
Fatigue | 21.74 | 10.03 | 5482 | 426184 | 743248 | 63323818 |
Pulseless electrical activity | 21.73 | 10.03 | 153 | 431513 | 12586 | 64054480 |
Basal ganglia haemorrhage | 21.71 | 10.03 | 36 | 431630 | 1370 | 64065696 |
Systemic infection | 21.69 | 10.03 | 71 | 431595 | 4250 | 64062816 |
Allergic reaction to excipient | 21.69 | 10.03 | 16 | 431650 | 236 | 64066830 |
Chronic obstructive pulmonary disease | 21.67 | 10.03 | 626 | 431040 | 70422 | 63996644 |
Lymphoproliferative disorder | 21.58 | 10.03 | 4 | 431662 | 5099 | 64061967 |
Body height decreased | 21.58 | 10.03 | 104 | 431562 | 7450 | 64059616 |
Ejection fraction decreased | 21.54 | 10.03 | 290 | 431376 | 28417 | 64038649 |
Oral herpes | 21.48 | 10.03 | 76 | 431590 | 22076 | 64044990 |
Product substitution issue | 21.46 | 10.03 | 198 | 431468 | 17663 | 64049403 |
Electrocardiogram QRS complex prolonged | 21.37 | 10.03 | 120 | 431546 | 9124 | 64057942 |
Rash erythematous | 21.34 | 10.03 | 215 | 431451 | 48418 | 64018648 |
Blood pressure systolic abnormal | 21.32 | 10.03 | 21 | 431645 | 9921 | 64057145 |
Dyskinesia | 21.31 | 10.03 | 165 | 431501 | 39223 | 64027843 |
Drug use disorder | 21.23 | 10.03 | 7 | 431659 | 6047 | 64061019 |
Drug-disease interaction | 21.21 | 10.03 | 26 | 431640 | 745 | 64066321 |
Acne | 21.19 | 10.03 | 81 | 431585 | 23000 | 64044066 |
Aplasia | 21.16 | 10.03 | 10 | 431656 | 6943 | 64060123 |
Haemarthrosis | 21.14 | 10.03 | 80 | 431586 | 5149 | 64061917 |
Human herpesvirus 6 infection | 21.13 | 10.03 | 3 | 431663 | 4651 | 64062415 |
Mucosal haemorrhage | 21.12 | 10.03 | 47 | 431619 | 2234 | 64064832 |
Tooth erosion | 21.12 | 10.03 | 19 | 431647 | 376 | 64066690 |
Electrolyte imbalance | 21.04 | 10.03 | 260 | 431406 | 24983 | 64042083 |
Coronary artery restenosis | 21.00 | 10.03 | 34 | 431632 | 1268 | 64065798 |
Flushing | 20.98 | 10.03 | 385 | 431281 | 78263 | 63988803 |
CD30 expression | 20.96 | 10.03 | 9 | 431657 | 41 | 64067025 |
Bundle branch block right | 20.96 | 10.03 | 129 | 431537 | 10140 | 64056926 |
Hypomania | 20.79 | 10.03 | 6 | 431660 | 5648 | 64061418 |
Leukopenia | 20.77 | 10.03 | 517 | 431149 | 100725 | 63966341 |
Aortic aneurysm | 20.72 | 10.03 | 103 | 431563 | 7471 | 64059595 |
Implantable defibrillator insertion | 20.68 | 10.03 | 26 | 431640 | 765 | 64066301 |
Hypoaesthesia | 20.67 | 10.03 | 742 | 430924 | 138366 | 63928700 |
Pulse absent | 20.60 | 10.03 | 116 | 431550 | 8830 | 64058236 |
Amenorrhoea | 20.53 | 10.03 | 9 | 431657 | 6530 | 64060536 |
Exercise tolerance decreased | 20.49 | 10.03 | 104 | 431562 | 7606 | 64059460 |
Hypertensive heart disease | 20.46 | 10.03 | 64 | 431602 | 3740 | 64063326 |
Cytomegalovirus chorioretinitis | 20.45 | 10.03 | 4 | 431662 | 4908 | 64062158 |
Hypoalbuminaemia | 20.42 | 10.03 | 56 | 431610 | 17618 | 64049448 |
Hepatitis B reactivation | 20.31 | 10.03 | 4 | 431662 | 4885 | 64062181 |
Lymphadenopathy | 20.24 | 10.03 | 207 | 431459 | 46479 | 64020587 |
Hypoperfusion | 20.23 | 10.03 | 47 | 431619 | 2299 | 64064767 |
Injection site swelling | 20.21 | 10.03 | 178 | 431488 | 41175 | 64025891 |
Colitis | 20.09 | 10.03 | 274 | 431392 | 58400 | 64008666 |
Neuropathy peripheral | 20.03 | 10.03 | 616 | 431050 | 116909 | 63950157 |
Hyperammonaemia | 20.02 | 10.03 | 22 | 431644 | 9882 | 64057184 |
Prostatomegaly | 19.88 | 10.03 | 54 | 431612 | 2913 | 64064153 |
Hypomagnesaemia | 19.79 | 10.03 | 356 | 431310 | 37020 | 64030046 |
Labile hypertension | 19.76 | 10.03 | 21 | 431645 | 513 | 64066553 |
Product residue present | 19.75 | 10.03 | 57 | 431609 | 3185 | 64063881 |
Diverticulum intestinal | 19.66 | 10.03 | 100 | 431566 | 7320 | 64059746 |
Drug level increased | 19.65 | 10.03 | 330 | 431336 | 33866 | 64033200 |
Neuropathy vitamin B12 deficiency | 19.64 | 10.03 | 8 | 431658 | 31 | 64067035 |
QRS axis abnormal | 19.64 | 10.03 | 40 | 431626 | 1787 | 64065279 |
Obstructive airways disorder | 19.62 | 10.03 | 84 | 431582 | 23101 | 64043965 |
Non-cardiac chest pain | 19.62 | 10.03 | 112 | 431554 | 8568 | 64058498 |
Loss of employment | 19.61 | 10.03 | 41 | 431625 | 1866 | 64065200 |
Embolic stroke | 19.61 | 10.03 | 93 | 431573 | 6618 | 64060448 |
Non-cardiogenic pulmonary oedema | 19.55 | 10.03 | 33 | 431633 | 1275 | 64065791 |
Cerebrospinal fluid retention | 19.46 | 10.03 | 10 | 431656 | 73 | 64066993 |
Carotid artery occlusion | 19.27 | 10.03 | 65 | 431601 | 3952 | 64063114 |
Extrasystoles | 19.26 | 10.03 | 92 | 431574 | 6566 | 64060500 |
Metastases to bone | 19.22 | 10.03 | 71 | 431595 | 20364 | 64046702 |
Respiratory tract infection | 19.18 | 10.03 | 159 | 431507 | 37248 | 64029818 |
Vascular resistance pulmonary decreased | 19.13 | 10.03 | 10 | 431656 | 76 | 64066990 |
Gastrointestinal arteriovenous malformation | 19.09 | 10.03 | 27 | 431639 | 892 | 64066174 |
Graft versus host disease in skin | 19.07 | 10.03 | 6 | 431660 | 5341 | 64061725 |
Carcinoma in situ of skin | 19.00 | 10.03 | 13 | 431653 | 169 | 64066897 |
Dizziness postural | 18.97 | 10.03 | 121 | 431545 | 9631 | 64057435 |
Intraventricular haemorrhage | 18.87 | 10.03 | 66 | 431600 | 4087 | 64062979 |
Penile haemorrhage | 18.87 | 10.03 | 20 | 431646 | 487 | 64066579 |
Diverticulum | 18.84 | 10.03 | 152 | 431514 | 13046 | 64054020 |
Blood glucose decreased | 18.78 | 10.03 | 237 | 431429 | 22886 | 64044180 |
Blood creatine increased | 18.71 | 10.03 | 106 | 431560 | 8086 | 64058980 |
Drug tolerance decreased | 18.50 | 10.03 | 12 | 431654 | 6986 | 64060080 |
Haemorrhagic stroke | 18.45 | 10.03 | 122 | 431544 | 9829 | 64057237 |
Thrombin time prolonged | 18.45 | 10.03 | 16 | 431650 | 301 | 64066765 |
Subchondral insufficiency fracture | 18.44 | 10.03 | 9 | 431657 | 58 | 64067008 |
Carotid artery stenosis | 18.30 | 10.03 | 103 | 431563 | 7838 | 64059228 |
Hepatojugular reflux | 18.23 | 10.03 | 20 | 431646 | 507 | 64066559 |
Antiacetylcholine receptor antibody positive | 18.19 | 10.03 | 9 | 431657 | 60 | 64067006 |
Oropharyngeal pain | 18.17 | 10.03 | 454 | 431212 | 88413 | 63978653 |
Anticoagulation drug level above therapeutic | 18.04 | 10.03 | 53 | 431613 | 2992 | 64064074 |
Drug withdrawal syndrome | 17.92 | 10.03 | 129 | 431537 | 31162 | 64035904 |
Oral candidiasis | 17.92 | 10.03 | 87 | 431579 | 23125 | 64043941 |
Lacunar infarction | 17.90 | 10.03 | 79 | 431587 | 5453 | 64061613 |
Ischaemic hepatitis | 17.82 | 10.03 | 55 | 431611 | 3191 | 64063875 |
Mitral valve disease | 17.67 | 10.03 | 48 | 431618 | 2590 | 64064476 |
Dysgeusia | 17.66 | 10.03 | 426 | 431240 | 46621 | 64020445 |
Nocardiosis | 17.64 | 10.03 | 5 | 431661 | 4762 | 64062304 |
Macrophages increased | 17.61 | 10.03 | 13 | 431653 | 192 | 64066874 |
Bacterial parotitis | 17.57 | 10.03 | 6 | 431660 | 12 | 64067054 |
Femur fracture | 17.54 | 10.03 | 145 | 431521 | 33990 | 64033076 |
Disease recurrence | 17.52 | 10.03 | 131 | 431535 | 31379 | 64035687 |
Faeces pale | 17.44 | 10.03 | 47 | 431619 | 2524 | 64064542 |
Blood potassium decreased | 17.41 | 10.03 | 373 | 431293 | 40026 | 64027040 |
Osteonecrosis | 17.35 | 10.03 | 114 | 431552 | 28115 | 64038951 |
White blood cell count decreased | 17.34 | 10.03 | 871 | 430795 | 156966 | 63910100 |
High density lipoprotein decreased | 17.32 | 10.03 | 62 | 431604 | 3884 | 64063182 |
Device use error | 17.23 | 10.03 | 11 | 431655 | 6460 | 64060606 |
Immune thrombocytopenia | 17.21 | 10.03 | 48 | 431618 | 15018 | 64052048 |
Orthostatic hypotension | 17.18 | 10.03 | 422 | 431244 | 46316 | 64020750 |
Subarachnoid haemorrhage | 17.18 | 10.03 | 194 | 431472 | 18244 | 64048822 |
Enterocolitis | 17.16 | 10.03 | 34 | 431632 | 11984 | 64055082 |
Muscle necrosis | 17.15 | 10.03 | 30 | 431636 | 1193 | 64065873 |
Somnolence | 17.12 | 10.03 | 1153 | 430513 | 202492 | 63864574 |
Extrapyramidal disorder | 17.07 | 10.03 | 70 | 431596 | 19482 | 64047584 |
Leukoencephalopathy | 17.03 | 10.03 | 13 | 431653 | 6954 | 64060112 |
Cerebral artery occlusion | 17.00 | 10.03 | 35 | 431631 | 1576 | 64065490 |
Skin induration | 16.98 | 10.03 | 64 | 431602 | 4111 | 64062955 |
Oesophageal obstruction | 16.92 | 10.03 | 24 | 431642 | 795 | 64066271 |
Herpes zoster | 16.89 | 10.03 | 402 | 431264 | 78785 | 63988281 |
Shock | 16.78 | 10.03 | 354 | 431312 | 37886 | 64029180 |
Left atrial enlargement | 16.72 | 10.03 | 27 | 431639 | 1005 | 64066061 |
Transplant rejection | 16.67 | 10.03 | 60 | 431606 | 17341 | 64049725 |
Neurotoxicity | 16.67 | 10.03 | 111 | 431555 | 27293 | 64039773 |
Left-to-right cardiac shunt | 16.66 | 10.03 | 10 | 431656 | 102 | 64066964 |
Herpes simplex | 16.66 | 10.03 | 28 | 431638 | 10508 | 64056558 |
Hyperbilirubinaemia | 16.64 | 10.03 | 79 | 431587 | 21126 | 64045940 |
Mitral valve sclerosis | 16.52 | 10.03 | 14 | 431652 | 255 | 64066811 |
Autoimmune myositis | 16.49 | 10.03 | 12 | 431654 | 173 | 64066893 |
Wheezing | 16.39 | 10.03 | 412 | 431254 | 80167 | 63986899 |
Demyelination | 16.39 | 10.03 | 13 | 431653 | 6821 | 64060245 |
Multiple injuries | 16.38 | 10.03 | 54 | 431612 | 3245 | 64063821 |
Acute myeloid leukaemia | 16.33 | 10.03 | 112 | 431554 | 27351 | 64039715 |
Nephrectomy | 16.32 | 10.03 | 32 | 431634 | 1390 | 64065676 |
Traumatic haemorrhage | 16.29 | 10.03 | 28 | 431638 | 1098 | 64065968 |
Osteonecrosis of jaw | 16.28 | 10.03 | 179 | 431487 | 39646 | 64027420 |
Dialysis | 16.21 | 10.03 | 179 | 431487 | 16741 | 64050325 |
Obsessive-compulsive disorder | 16.16 | 10.03 | 6 | 431660 | 4812 | 64062254 |
Albumin urine present | 16.13 | 10.03 | 21 | 431645 | 640 | 64066426 |
Secretion discharge | 16.11 | 10.03 | 35 | 431631 | 11929 | 64055137 |
Posterior reversible encephalopathy syndrome | 16.02 | 10.03 | 89 | 431577 | 22857 | 64044209 |
Metabolic syndrome | 16 | 10.03 | 43 | 431623 | 2305 | 64064761 |
Tachycardia | 15.99 | 10.03 | 1185 | 430481 | 148394 | 63918672 |
Heart valve incompetence | 15.96 | 10.03 | 48 | 431618 | 2745 | 64064321 |
Osmolar gap increased | 15.95 | 10.03 | 7 | 431659 | 34 | 64067032 |
Accidental exposure to product | 15.93 | 10.03 | 107 | 431559 | 26257 | 64040809 |
Hypoaldosteronism | 15.91 | 10.03 | 15 | 431651 | 316 | 64066750 |
Duodenal ulcer | 15.85 | 10.03 | 157 | 431509 | 14278 | 64052788 |
Dermatitis exfoliative generalised | 15.83 | 10.03 | 10 | 431656 | 5906 | 64061160 |
Fear of injection | 15.81 | 10.03 | 10 | 431656 | 5902 | 64061164 |
Cardiovascular somatic symptom disorder | 15.79 | 10.03 | 7 | 431659 | 35 | 64067031 |
Heparin-induced thrombocytopenia | 15.75 | 10.03 | 104 | 431562 | 8375 | 64058691 |
Upper motor neurone lesion | 15.74 | 10.03 | 13 | 431653 | 228 | 64066838 |
Dermatitis acneiform | 15.74 | 10.03 | 20 | 431646 | 8423 | 64058643 |
Blood urea increased | 15.73 | 10.03 | 397 | 431269 | 43756 | 64023310 |
Central nervous system lesion | 15.68 | 10.03 | 35 | 431631 | 11814 | 64055252 |
Blood sodium decreased | 15.67 | 10.03 | 281 | 431385 | 29201 | 64037865 |
Gastrointestinal toxicity | 15.67 | 10.03 | 8 | 431658 | 5314 | 64061752 |
Appendicitis | 15.67 | 10.03 | 43 | 431623 | 13526 | 64053540 |
Hypertransaminasaemia | 15.64 | 10.03 | 15 | 431651 | 7176 | 64059890 |
Muscle spasticity | 15.62 | 10.03 | 58 | 431608 | 16611 | 64050455 |
Ulcer | 15.61 | 10.03 | 90 | 431576 | 22900 | 64044166 |
Loss of personal independence in daily activities | 15.40 | 10.03 | 368 | 431298 | 72086 | 63994980 |
Actinic keratosis | 15.40 | 10.03 | 72 | 431594 | 5093 | 64061973 |
Blood pressure abnormal | 15.37 | 10.03 | 156 | 431510 | 14279 | 64052787 |
Retroperitoneal haemorrhage | 15.36 | 10.03 | 69 | 431597 | 4799 | 64062267 |
Lymphatic fistula | 15.35 | 10.03 | 22 | 431644 | 736 | 64066330 |
Catatonia | 15.32 | 10.03 | 17 | 431649 | 7603 | 64059463 |
Neutrophil function disorder | 15.20 | 10.03 | 6 | 431660 | 21 | 64067045 |
Coronary artery thrombosis | 15.18 | 10.03 | 48 | 431618 | 2821 | 64064245 |
Ear infection | 15.16 | 10.03 | 93 | 431573 | 23311 | 64043755 |
Exposure via ingestion | 15.11 | 10.03 | 69 | 431597 | 4833 | 64062233 |
Malignant polyp | 15.10 | 10.03 | 11 | 431655 | 159 | 64066907 |
Renal atrophy | 15.09 | 10.03 | 34 | 431632 | 1630 | 64065436 |
Blood alkaline phosphatase abnormal | 15.04 | 10.03 | 22 | 431644 | 750 | 64066316 |
Phaeochromocytoma crisis | 14.92 | 10.03 | 14 | 431652 | 293 | 64066773 |
Product dose omission issue | 14.90 | 10.03 | 1505 | 430161 | 193242 | 63873824 |
Incorrect route of product administration | 14.87 | 10.03 | 93 | 431573 | 23205 | 64043861 |
Fibromyalgia | 14.85 | 10.03 | 160 | 431506 | 35571 | 64031495 |
Phaeochromocytoma | 14.83 | 10.03 | 19 | 431647 | 570 | 64066496 |
Portal fibrosis | 14.80 | 10.03 | 19 | 431647 | 571 | 64066495 |
Stevens-Johnson syndrome | 14.78 | 10.03 | 152 | 431514 | 34097 | 64032969 |
Peripheral sensory neuropathy | 14.74 | 10.03 | 34 | 431632 | 11344 | 64055722 |
Aplastic anaemia | 14.70 | 10.03 | 46 | 431620 | 13874 | 64053192 |
Thoracic haemorrhage | 14.70 | 10.03 | 12 | 431654 | 207 | 64066859 |
Muscular weakness | 14.67 | 10.03 | 1015 | 430651 | 126323 | 63940743 |
Diarrhoea | 14.66 | 10.03 | 5216 | 426450 | 717488 | 63349578 |
Depressed mood | 14.60 | 10.03 | 190 | 431476 | 40822 | 64026244 |
Thalamus haemorrhage | 14.59 | 10.03 | 33 | 431633 | 1586 | 64065480 |
Haemorrhagic transformation stroke | 14.55 | 10.03 | 42 | 431624 | 2347 | 64064719 |
Aortic valve stenosis | 14.51 | 10.03 | 65 | 431601 | 4515 | 64062551 |
Respiratory disorder | 14.49 | 10.03 | 163 | 431503 | 35948 | 64031118 |
Altered state of consciousness | 14.46 | 10.03 | 173 | 431493 | 37729 | 64029337 |
Sudden cardiac death | 14.46 | 10.03 | 65 | 431601 | 4522 | 64062544 |
Device related infection | 14.45 | 10.03 | 133 | 431533 | 30493 | 64036573 |
Cytokine release syndrome | 14.43 | 10.03 | 81 | 431585 | 20748 | 64046318 |
Grip strength decreased | 14.42 | 10.03 | 36 | 431630 | 11688 | 64055378 |
Total cholesterol/HDL ratio increased | 14.41 | 10.03 | 12 | 431654 | 213 | 64066853 |
Coeliac disease | 14.40 | 10.03 | 17 | 431649 | 7395 | 64059671 |
Autoimmune myocarditis | 14.38 | 10.03 | 13 | 431653 | 259 | 64066807 |
Pleural mass | 14.36 | 10.03 | 8 | 431658 | 70 | 64066996 |
Computerised tomogram head abnormal | 14.34 | 10.03 | 9 | 431657 | 100 | 64066966 |
Abdominal pain lower | 14.33 | 10.03 | 253 | 431413 | 26216 | 64040850 |
Gouty arthritis | 14.28 | 10.03 | 29 | 431637 | 1293 | 64065773 |
Tenderness | 14.26 | 10.03 | 75 | 431591 | 19527 | 64047539 |
Electrocardiogram ST-T segment abnormal | 14.25 | 10.03 | 17 | 431649 | 473 | 64066593 |
Food allergy | 14.22 | 10.03 | 19 | 431647 | 7832 | 64059234 |
Chronic left ventricular failure | 14.20 | 10.03 | 21 | 431645 | 723 | 64066343 |
Blood creatinine abnormal | 14.17 | 10.03 | 60 | 431606 | 4067 | 64062999 |
Aspartate aminotransferase increased | 14.15 | 10.03 | 656 | 431010 | 119132 | 63947934 |
Carotid artery disease | 14.13 | 10.03 | 39 | 431627 | 2124 | 64064942 |
Sprue-like enteropathy | 14.12 | 10.03 | 25 | 431641 | 1004 | 64066062 |
Multiple sclerosis relapse | 14.12 | 10.03 | 192 | 431474 | 40943 | 64026123 |
Palmar-plantar erythrodysaesthesia syndrome | 14.10 | 10.03 | 124 | 431542 | 28695 | 64038371 |
Injury | 14.08 | 10.03 | 482 | 431184 | 55510 | 64011556 |
Arteriosclerotic gangrene | 14.08 | 10.03 | 8 | 431658 | 73 | 64066993 |
Emotional distress | 14.04 | 10.03 | 328 | 431338 | 35710 | 64031356 |
Ascites | 13.99 | 10.03 | 312 | 431354 | 61689 | 64005377 |
Clonus | 13.98 | 10.03 | 12 | 431654 | 6055 | 64061011 |
Schizophrenia | 13.96 | 10.03 | 34 | 431632 | 11134 | 64055932 |
Prothrombin time prolonged | 13.94 | 10.03 | 164 | 431502 | 15577 | 64051489 |
Mydriasis | 13.89 | 10.03 | 54 | 431612 | 15258 | 64051808 |
Left ventricular hypertrophy | 13.85 | 10.03 | 110 | 431556 | 9396 | 64057670 |
Cerebellar haemorrhage | 13.85 | 10.03 | 44 | 431622 | 2593 | 64064473 |
Femoral hernia incarcerated | 13.84 | 10.03 | 21 | 431645 | 740 | 64066326 |
Photophobia | 13.82 | 10.03 | 64 | 431602 | 17229 | 64049837 |
Tumour lysis syndrome | 13.79 | 10.03 | 75 | 431591 | 19365 | 64047701 |
Carcinoid tumour | 13.79 | 10.03 | 16 | 431650 | 432 | 64066634 |
International normalised ratio abnormal | 13.76 | 10.03 | 68 | 431598 | 4920 | 64062146 |
Mood swings | 13.76 | 10.03 | 65 | 431601 | 17403 | 64049663 |
Hyperhidrosis | 13.75 | 10.03 | 992 | 430674 | 123928 | 63943138 |
Disability | 13.74 | 10.03 | 39 | 431627 | 12133 | 64054933 |
Haemorrhoidal haemorrhage | 13.73 | 10.03 | 75 | 431591 | 5644 | 64061422 |
Left ventricular failure | 13.73 | 10.03 | 100 | 431566 | 8317 | 64058749 |
Type IIa hyperlipidaemia | 13.70 | 10.03 | 11 | 431655 | 185 | 64066881 |
Diabetic nephropathy | 13.68 | 10.03 | 44 | 431622 | 2610 | 64064456 |
Cell death | 13.68 | 10.03 | 5 | 431661 | 4049 | 64063017 |
Akathisia | 13.65 | 10.03 | 36 | 431630 | 11474 | 64055592 |
Hepatitis acute | 13.62 | 10.03 | 45 | 431621 | 13344 | 64053722 |
Intracranial pressure increased | 13.61 | 10.03 | 16 | 431650 | 6973 | 64060093 |
Faeces discoloured | 13.60 | 10.03 | 245 | 431421 | 25484 | 64041582 |
Paronychia | 13.59 | 10.03 | 14 | 431652 | 6478 | 64060588 |
Shone complex | 13.53 | 10.03 | 6 | 431660 | 30 | 64067036 |
Mitral valve hypoplasia | 13.53 | 10.03 | 6 | 431660 | 30 | 64067036 |
Lipodystrophy acquired | 13.53 | 10.03 | 5 | 431661 | 4022 | 64063044 |
Acute lymphocytic leukaemia recurrent | 13.52 | 10.03 | 5 | 431661 | 4021 | 64063045 |
Paraesthesia | 13.52 | 10.03 | 749 | 430917 | 133773 | 63933293 |
Mitral valve stenosis | 13.52 | 10.03 | 25 | 431641 | 1039 | 64066027 |
Cytomegalovirus viraemia | 13.51 | 10.03 | 33 | 431633 | 10795 | 64056271 |
Therapeutic response shortened | 13.49 | 10.03 | 30 | 431636 | 10140 | 64056926 |
Parathyroid hormone-related protein abnormal | 13.49 | 10.03 | 5 | 431661 | 14 | 64067052 |
Aortic arteriosclerosis | 13.47 | 10.03 | 91 | 431575 | 7385 | 64059681 |
Myopathy | 13.43 | 10.03 | 179 | 431487 | 17501 | 64049565 |
Seroma | 13.38 | 10.03 | 37 | 431629 | 2017 | 64065049 |
Congenital aortic valve stenosis | 13.37 | 10.03 | 6 | 431660 | 31 | 64067035 |
Hypertriglyceridaemia | 13.32 | 10.03 | 35 | 431631 | 11170 | 64055896 |
Dilatation atrial | 13.31 | 10.03 | 52 | 431614 | 3398 | 64063668 |
Aorta hypoplasia | 13.22 | 10.03 | 6 | 431660 | 32 | 64067034 |
Inspiratory capacity abnormal | 13.21 | 10.03 | 8 | 431658 | 83 | 64066983 |
Eructation | 13.20 | 10.03 | 106 | 431560 | 9085 | 64057981 |
Malignant neoplasm of eye | 13.19 | 10.03 | 7 | 431659 | 55 | 64067011 |
Glucose tolerance impaired | 13.19 | 10.03 | 81 | 431585 | 6362 | 64060704 |
Disseminated tuberculosis | 13.16 | 10.03 | 4 | 431662 | 3641 | 64063425 |
Colitis ulcerative | 13.16 | 10.03 | 95 | 431571 | 22933 | 64044133 |
Catheterisation cardiac | 13.14 | 10.03 | 66 | 431600 | 4807 | 64062259 |
Multiple drug therapy | 13.13 | 10.03 | 39 | 431627 | 2215 | 64064851 |
Conjunctivitis | 13.12 | 10.03 | 81 | 431585 | 20273 | 64046793 |
Deep vein thrombosis | 13.11 | 10.03 | 844 | 430822 | 104338 | 63962728 |
Aortic valve replacement | 13.05 | 10.03 | 26 | 431640 | 1143 | 64065923 |
Paradoxical drug reaction | 13.04 | 10.03 | 13 | 431653 | 6107 | 64060959 |
Listless | 13.03 | 10.03 | 50 | 431616 | 3240 | 64063826 |
Cardiac function test abnormal | 13.02 | 10.03 | 9 | 431657 | 119 | 64066947 |
Intracardiac thrombus | 13.00 | 10.03 | 55 | 431611 | 3726 | 64063340 |
Throat irritation | 12.99 | 10.03 | 148 | 431518 | 32563 | 64034503 |
Ejection fraction abnormal | 12.95 | 10.03 | 29 | 431637 | 1384 | 64065682 |
Systemic candida | 12.95 | 10.03 | 10 | 431656 | 5319 | 64061747 |
Ultrasound kidney abnormal | 12.93 | 10.03 | 6 | 431660 | 34 | 64067032 |
Device difficult to use | 12.92 | 10.03 | 29 | 431637 | 9769 | 64057297 |
Muscle oedema | 12.90 | 10.03 | 9 | 431657 | 121 | 64066945 |
Dementia | 12.90 | 10.03 | 203 | 431463 | 20563 | 64046503 |
Depressive symptom | 12.88 | 10.03 | 7 | 431659 | 4489 | 64062577 |
Histology abnormal | 12.83 | 10.03 | 13 | 431653 | 300 | 64066766 |
Coronary angioplasty | 12.82 | 10.03 | 14 | 431652 | 353 | 64066713 |
Uterine perforation | 12.82 | 10.03 | 12 | 431654 | 5808 | 64061258 |
Pruritus genital | 12.80 | 10.03 | 24 | 431642 | 1008 | 64066058 |
Paranoia | 12.79 | 10.03 | 61 | 431605 | 16291 | 64050775 |
Disturbance in social behaviour | 12.77 | 10.03 | 5 | 431661 | 3882 | 64063184 |
Heavy menstrual bleeding | 12.69 | 10.03 | 40 | 431626 | 12037 | 64055029 |
Skin hypertrophy | 12.68 | 10.03 | 62 | 431604 | 4467 | 64062599 |
Renal cell carcinoma | 12.66 | 10.03 | 77 | 431589 | 6027 | 64061039 |
Aspiration pleural cavity | 12.65 | 10.03 | 29 | 431637 | 1406 | 64065660 |
Embolic cerebral infarction | 12.63 | 10.03 | 25 | 431641 | 1094 | 64065972 |
Hypoxia | 12.62 | 10.03 | 716 | 430950 | 87433 | 63979633 |
Menstruation irregular | 12.57 | 10.03 | 7 | 431659 | 4428 | 64062638 |
Skin tightness | 12.55 | 10.03 | 66 | 431600 | 4895 | 64062171 |
Fungal infection | 12.44 | 10.03 | 158 | 431508 | 34093 | 64032973 |
Optic neuritis | 12.44 | 10.03 | 22 | 431644 | 8094 | 64058972 |
Echocardiogram abnormal | 12.43 | 10.03 | 33 | 431633 | 1756 | 64065310 |
Vasoconstriction | 12.39 | 10.03 | 18 | 431648 | 610 | 64066456 |
Biopsy lymph gland | 12.37 | 10.03 | 8 | 431658 | 94 | 64066972 |
Gastritis erosive | 12.37 | 10.03 | 108 | 431558 | 9487 | 64057579 |
Renal function test abnormal | 12.29 | 10.03 | 56 | 431610 | 3918 | 64063148 |
Encephalitis | 12.27 | 10.03 | 43 | 431623 | 12528 | 64054538 |
Mood altered | 12.27 | 10.03 | 60 | 431606 | 15919 | 64051147 |
Ulcer haemorrhage | 12.23 | 10.03 | 61 | 431605 | 4431 | 64062635 |
Cardiovascular insufficiency | 12.19 | 10.03 | 42 | 431624 | 2582 | 64064484 |
Hyperthyroidism | 12.17 | 10.03 | 180 | 431486 | 17999 | 64049067 |
Patent ductus arteriosus | 12.16 | 10.03 | 8 | 431658 | 97 | 64066969 |
Pseudomonas infection | 12.14 | 10.03 | 70 | 431596 | 17813 | 64049253 |
Congenital heart valve disorder | 12.13 | 10.03 | 6 | 431660 | 40 | 64067026 |
Anticoagulation drug level below therapeutic | 12.11 | 10.03 | 27 | 431639 | 1285 | 64065781 |
Electrocardiogram QRS complex shortened | 12.10 | 10.03 | 18 | 431648 | 623 | 64066443 |
Rhinitis allergic | 12.06 | 10.03 | 94 | 431572 | 7984 | 64059082 |
Blood cholinesterase decreased | 12.05 | 10.03 | 11 | 431655 | 222 | 64066844 |
Venous pressure jugular abnormal | 12.04 | 10.03 | 3 | 431663 | 0 | 64067066 |
Alveolar-arterial oxygen gradient increased | 12.04 | 10.03 | 3 | 431663 | 0 | 64067066 |
Diabetic dermopathy | 12.04 | 10.03 | 3 | 431663 | 0 | 64067066 |
Drug screen | 12.04 | 10.03 | 3 | 431663 | 0 | 64067066 |
Eosinophil count increased | 12.02 | 10.03 | 51 | 431615 | 14061 | 64053005 |
Apallic syndrome | 11.96 | 10.03 | 21 | 431645 | 838 | 64066228 |
Autoimmune haemolytic anaemia | 11.95 | 10.03 | 18 | 431648 | 7058 | 64060008 |
Neutropenic colitis | 11.91 | 10.03 | 8 | 431658 | 4573 | 64062493 |
Retching | 11.81 | 10.03 | 155 | 431511 | 15101 | 64051965 |
Left ventricular dysfunction | 11.80 | 10.03 | 169 | 431497 | 16785 | 64050281 |
Social avoidant behaviour | 11.79 | 10.03 | 8 | 431658 | 4549 | 64062517 |
Hypercalcaemia | 11.76 | 10.03 | 144 | 431522 | 31272 | 64035794 |
Myocardial hypoxia | 11.71 | 10.03 | 4 | 431662 | 8 | 64067058 |
Tonsillitis | 11.69 | 10.03 | 13 | 431653 | 5807 | 64061259 |
Drug abuser | 11.63 | 10.03 | 13 | 431653 | 5795 | 64061271 |
Soft tissue haemorrhage | 11.59 | 10.03 | 13 | 431653 | 338 | 64066728 |
JC virus infection | 11.55 | 10.03 | 4 | 431662 | 3351 | 64063715 |
Ventricular hypertrophy | 11.55 | 10.03 | 79 | 431587 | 6437 | 64060629 |
Hospice care | 11.54 | 10.03 | 89 | 431577 | 7536 | 64059530 |
Joint stiffness | 11.51 | 10.03 | 139 | 431527 | 30265 | 64036801 |
Blood pressure orthostatic | 11.45 | 10.03 | 7 | 431659 | 74 | 64066992 |
Sacroiliitis | 11.44 | 10.03 | 3 | 431663 | 3009 | 64064057 |
Complication of device insertion | 11.44 | 10.03 | 10 | 431656 | 5002 | 64062064 |
Total cholesterol/HDL ratio decreased | 11.44 | 10.03 | 5 | 431661 | 24 | 64067042 |
Iliac artery stenosis | 11.44 | 10.03 | 8 | 431658 | 108 | 64066958 |
Joint destruction | 11.42 | 10.03 | 5 | 431661 | 3631 | 64063435 |
Intraocular pressure increased | 11.42 | 10.03 | 24 | 431642 | 8278 | 64058788 |
Polymyositis | 11.41 | 10.03 | 42 | 431624 | 2668 | 64064398 |
Antithyroid arthritis syndrome | 11.40 | 10.03 | 4 | 431662 | 9 | 64067057 |
Carcinoid tumour of the gastrointestinal tract | 11.37 | 10.03 | 7 | 431659 | 75 | 64066991 |
Peripheral coldness | 11.36 | 10.03 | 140 | 431526 | 13444 | 64053622 |
Abdominal pain | 11.36 | 10.03 | 1877 | 429789 | 310498 | 63756568 |
Flatulence | 11.36 | 10.03 | 316 | 431350 | 35350 | 64031716 |
Facial bones fracture | 11.35 | 10.03 | 58 | 431608 | 4254 | 64062812 |
Cyanopsia | 11.29 | 10.03 | 7 | 431659 | 76 | 64066990 |
Supravalvular aortic stenosis | 11.28 | 10.03 | 5 | 431661 | 25 | 64067041 |
Congenital aortic stenosis | 11.28 | 10.03 | 5 | 431661 | 25 | 64067041 |
Congenital aortic anomaly | 11.28 | 10.03 | 5 | 431661 | 25 | 64067041 |
Post-anoxic myoclonus | 11.28 | 10.03 | 5 | 431661 | 25 | 64067041 |
Pneumatosis intestinalis | 11.27 | 10.03 | 11 | 431655 | 5218 | 64061848 |
Supraventricular extrasystoles | 11.26 | 10.03 | 73 | 431593 | 5842 | 64061224 |
Skin fibrosis | 11.26 | 10.03 | 28 | 431638 | 1431 | 64065635 |
Calciphylaxis | 11.25 | 10.03 | 48 | 431618 | 3264 | 64063802 |
Cerebral ischaemia | 11.25 | 10.03 | 109 | 431557 | 9853 | 64057213 |
Exostosis | 11.25 | 10.03 | 39 | 431627 | 11399 | 64055667 |
Accelerated hypertension | 11.25 | 10.03 | 17 | 431649 | 597 | 64066469 |
Dry eye | 11.25 | 10.03 | 132 | 431534 | 28887 | 64038179 |
Ventricular dyssynchrony | 11.22 | 10.03 | 6 | 431660 | 48 | 64067018 |
Arteriovenous fistula occlusion | 11.21 | 10.03 | 16 | 431650 | 533 | 64066533 |
Eczema | 11.21 | 10.03 | 136 | 431530 | 29584 | 64037482 |
Jaundice cholestatic | 11.15 | 10.03 | 26 | 431640 | 8644 | 64058422 |
Blood pressure fluctuation | 11.15 | 10.03 | 263 | 431403 | 51608 | 64015458 |
Electrocardiogram ST segment elevation | 11.13 | 10.03 | 85 | 431581 | 7174 | 64059892 |
Blood creatine phosphokinase MB abnormal | 11.12 | 10.03 | 5 | 431661 | 26 | 64067040 |
Negative cardiac inotropic effect | 11.11 | 10.03 | 4 | 431662 | 10 | 64067056 |
Blood pressure immeasurable | 11.10 | 10.03 | 33 | 431633 | 1875 | 64065191 |
Fracture blisters | 11.06 | 10.03 | 7 | 431659 | 79 | 64066987 |
Haemoptysis | 11.05 | 10.03 | 417 | 431249 | 48631 | 64018435 |
Ischaemia | 11.04 | 10.03 | 85 | 431581 | 7193 | 64059873 |
Head injury | 11.03 | 10.03 | 293 | 431373 | 32549 | 64034517 |
Urinary tract infection | 11.01 | 10.03 | 1738 | 429928 | 229858 | 63837208 |
Toxicity to various agents | 10.99 | 10.03 | 2667 | 428999 | 360846 | 63706220 |
Organising pneumonia | 10.98 | 10.03 | 28 | 431638 | 9027 | 64058039 |
Metastatic renal cell carcinoma | 10.95 | 10.03 | 36 | 431630 | 2160 | 64064906 |
Osteoporosis | 10.91 | 10.03 | 207 | 431459 | 41873 | 64025193 |
Body temperature increased | 10.90 | 10.03 | 176 | 431490 | 36490 | 64030576 |
Renal disorder | 10.89 | 10.03 | 312 | 431354 | 35053 | 64032013 |
Immune-mediated myositis | 10.85 | 10.03 | 41 | 431625 | 2637 | 64064429 |
Lupus pneumonitis | 10.84 | 10.03 | 7 | 431659 | 82 | 64066984 |
Blood pressure diastolic abnormal | 10.82 | 10.03 | 42 | 431624 | 11875 | 64055191 |
Galactorrhoea | 10.81 | 10.03 | 4 | 431662 | 3215 | 64063851 |
Drug ineffective for unapproved indication | 10.80 | 10.03 | 145 | 431521 | 30988 | 64036078 |
Splenic haemorrhage | 10.76 | 10.03 | 17 | 431649 | 621 | 64066445 |
Pancreatic steatosis | 10.75 | 10.03 | 22 | 431644 | 986 | 64066080 |
Suicidal behaviour | 10.73 | 10.03 | 3 | 431663 | 2884 | 64064182 |
Pneumonia cytomegaloviral | 10.73 | 10.03 | 8 | 431658 | 4331 | 64062735 |
Self-injurious ideation | 10.69 | 10.03 | 4 | 431662 | 3193 | 64063873 |
Aortic valve disease | 10.68 | 10.03 | 29 | 431637 | 1564 | 64065502 |
Chest wall haematoma | 10.67 | 10.03 | 13 | 431653 | 370 | 64066696 |
Hyperlactacidaemia | 10.66 | 10.03 | 10 | 431656 | 4834 | 64062232 |
Oedema due to cardiac disease | 10.63 | 10.03 | 6 | 431660 | 54 | 64067012 |
Myxoedema | 10.62 | 10.03 | 8 | 431658 | 122 | 64066944 |
Aortic aneurysm repair | 10.59 | 10.03 | 4 | 431662 | 12 | 64067054 |
Poor peripheral circulation | 10.58 | 10.03 | 46 | 431620 | 3154 | 64063912 |
Hemiparesis | 10.57 | 10.03 | 268 | 431398 | 29559 | 64037507 |
Venous pressure jugular increased | 10.56 | 10.03 | 25 | 431641 | 1238 | 64065828 |
Skin lesion | 10.55 | 10.03 | 176 | 431490 | 36306 | 64030760 |
Respiratory depression | 10.55 | 10.03 | 103 | 431563 | 23340 | 64043726 |
Blood urine present | 10.54 | 10.03 | 177 | 431489 | 18163 | 64048903 |
Gastrointestinal ulcer perforation | 10.54 | 10.03 | 5 | 431661 | 30 | 64067036 |
Tricuspid valve sclerosis | 10.54 | 10.03 | 5 | 431661 | 30 | 64067036 |
Crying | 10.48 | 10.03 | 85 | 431581 | 20005 | 64047061 |
Troponin I increased | 10.48 | 10.03 | 52 | 431614 | 3769 | 64063297 |
Pancreatitis acute | 10.44 | 10.03 | 213 | 431453 | 42642 | 64024424 |
Infection susceptibility increased | 10.44 | 10.03 | 41 | 431625 | 2685 | 64064381 |
Pyonephrosis | 10.43 | 10.03 | 7 | 431659 | 88 | 64066978 |
Brain natriuretic peptide increased | 10.41 | 10.03 | 87 | 431579 | 7546 | 64059520 |
Hyperreflexia | 10.40 | 10.03 | 20 | 431646 | 7128 | 64059938 |
Injection site haemorrhage | 10.38 | 10.03 | 108 | 431558 | 24170 | 64042896 |
Vaginal discharge | 10.37 | 10.03 | 7 | 431659 | 3990 | 64063076 |
Cystic fibrosis | 10.36 | 10.03 | 5 | 431661 | 3429 | 64063637 |
Polyarthritis | 10.33 | 10.03 | 32 | 431634 | 9683 | 64057383 |
Amaurosis fugax | 10.30 | 10.03 | 19 | 431647 | 788 | 64066278 |
Ear pain | 10.26 | 10.03 | 113 | 431553 | 25023 | 64042043 |
Haemodialysis | 10.25 | 10.03 | 166 | 431500 | 16911 | 64050155 |
Meningitis aseptic | 10.24 | 10.03 | 14 | 431652 | 5716 | 64061350 |
Gastric ulcer | 10.23 | 10.03 | 270 | 431396 | 29964 | 64037102 |
Activated partial thromboplastin time prolonged | 10.20 | 10.03 | 131 | 431535 | 12700 | 64054366 |
Hyperferritinaemia | 10.20 | 10.03 | 15 | 431651 | 514 | 64066552 |
Traumatic intracranial haemorrhage | 10.19 | 10.03 | 22 | 431644 | 1024 | 64066042 |
Electrocardiogram ST-T change | 10.19 | 10.03 | 28 | 431638 | 1521 | 64065545 |
Conjunctival cyst | 10.18 | 10.03 | 6 | 431660 | 59 | 64067007 |
Heart disease congenital | 10.18 | 10.03 | 15 | 431651 | 515 | 64066551 |
Electrocardiogram ST segment depression | 10.16 | 10.03 | 57 | 431609 | 4332 | 64062734 |
Cardioactive drug level increased | 10.11 | 10.03 | 48 | 431618 | 3417 | 64063649 |
Vascular access site occlusion | 10.10 | 10.03 | 6 | 431660 | 60 | 64067006 |
Coarctation of the aorta | 10.10 | 10.03 | 6 | 431660 | 60 | 64067006 |
Coronary artery insufficiency | 10.09 | 10.03 | 9 | 431657 | 176 | 64066890 |
Anal abscess | 10.08 | 10.03 | 22 | 431644 | 7486 | 64059580 |
Cardiac fibrillation | 10.07 | 10.03 | 20 | 431646 | 877 | 64066189 |
Rhinovirus infection | 10.07 | 10.03 | 16 | 431650 | 6140 | 64060926 |
Myocardial necrosis marker increased | 10.04 | 10.03 | 41 | 431625 | 2734 | 64064332 |
Gastric cyst | 10.04 | 10.03 | 7 | 431659 | 94 | 64066972 |
Sputum discoloured | 10.04 | 10.03 | 74 | 431592 | 17782 | 64049284 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neonatal respiratory failure | 33.10 | 28.61 | 23 | 878 | 187 | 83590 |
Source | Code | Description |
---|---|---|
ATC | C07AB02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, selective |
ATC | C07BB02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND THIAZIDES Beta blocking agents, selective, and thiazides |
ATC | C07BB52 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND THIAZIDES Beta blocking agents, selective, and thiazides |
ATC | C07CB02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND OTHER DIURETICS Beta blocking agents, selective, and other diuretics |
ATC | C07FB02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FB13 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FX03 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations |
ATC | C07FX05 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations |
FDA MoA | N0000000161 | Adrenergic beta-Antagonists |
FDA EPC | N0000175556 | beta-Adrenergic Blocker |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D058671 | Adrenergic beta-1 Receptor Antagonists |
MeSH PA | D000319 | Adrenergic beta-Antagonists |
MeSH PA | D000889 | Anti-Arrhythmia Agents |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D013565 | Sympatholytics |
CHEBI has role | CHEBI:35530 | beta-adrenergic blockers |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:176497 | geroprotectors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Myocardial infarction | indication | 22298006 | DOID:5844 |
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Angina pectoris | indication | 194828000 | |
Acute coronary syndrome | indication | 394659003 | |
Myocardial Reinfarction Prevention | indication | ||
Supraventricular tachycardia | off-label use | 6456007 | |
Ventricular tachycardia | off-label use | 25569003 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Multifocal atrial tachycardia | off-label use | 49982000 | |
Paroxysmal supraventricular tachycardia | off-label use | 67198005 | |
Thyrotoxicosis | off-label use | 90739004 | DOID:7997 |
Paroxysmal atrial tachycardia | off-label use | 195069001 | |
Ectopic atrial tachycardia | off-label use | 233892002 | |
Mitral valve prolapse | off-label use | 409712001 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Migraine Prevention | off-label use | ||
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia | off-label use | ||
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation | off-label use | ||
Pheochromocytoma Adjunct Therapy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Bronchospasm | contraindication | 4386001 | |
Psoriasis | contraindication | 9014002 | DOID:8893 |
Hypercholesterolemia | contraindication | 13644009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Hypovolemia | contraindication | 28560003 | |
Dehydration | contraindication | 34095006 | |
Depressive disorder | contraindication | 35489007 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
Anaphylaxis | contraindication | 39579001 | |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Sinus bradycardia | contraindication | 49710005 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Cardiogenic shock | contraindication | 89138009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Hypomagnesemia | contraindication | 190855004 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypoglycemic disorder | contraindication | 237630007 | |
Raynaud's phenomenon | contraindication | 266261006 | |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Pheochromocytoma | contraindication | 302835009 | |
Peripheral arterial occlusive disease | contraindication | 399957001 | |
Peripheral vascular disease | contraindication | 400047006 | |
Poor metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 423629005 | |
Azotemia | contraindication | 445009001 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
First Degree Atrioventricular Heart Block | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.19 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.60 | WOMBAT-PK | CHEMBL | |||
Beta-2 adrenergic receptor | GPCR | Ki | 6.30 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Kd | 6.79 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Kd | 7.83 | CHEMBL | |||||
Adrenergic receptor beta | GPCR | IC50 | 6.30 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 7.31 | CHEMBL |
ID | Source |
---|---|
D00601 | KEGG_DRUG |
80274-67-5 | SECONDARY_CAS_RN |
98418-47-4 | SECONDARY_CAS_RN |
56392-17-7 | SECONDARY_CAS_RN |
4018393 | VANDF |
4019836 | VANDF |
4020875 | VANDF |
C0025859 | UMLSCUI |
CHEBI:6904 | CHEBI |
CHEMBL13 | ChEMBL_ID |
CHEMBL3989566 | ChEMBL_ID |
CHEMBL1200337 | ChEMBL_ID |
CHEMBL2356097 | ChEMBL_ID |
DB00264 | DRUGBANK_ID |
CHEMBL2062335 | ChEMBL_ID |
D008790 | MESH_DESCRIPTOR_UI |
4171 | PUBCHEM_CID |
553 | IUPHAR_LIGAND_ID |
3471 | INN_ID |
GEB06NHM23 | UNII |
102313 | RXNORM |
1073 | MMSL |
5102 | MMSL |
5103 | MMSL |
d00134 | MMSL |
001853 | NDDF |
003627 | NDDF |
003628 | NDDF |
004135 | NDDF |
372826007 | SNOMEDCT_US |
412432007 | SNOMEDCT_US |
7092007 | SNOMEDCT_US |
72770009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9660 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 26 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9873 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 26 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0018 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0018 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0032 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0032 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0047 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0047 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0424 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
Metoprolol Tartrate and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0434 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Metoprolol Tartrate and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0445 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4593 | TABLET, FILM COATED | 37.50 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4593 | TABLET, FILM COATED | 37.50 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4594 | TABLET, FILM COATED | 75 mg | ORAL | ANDA | 23 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4594 | TABLET, FILM COATED | 75 mg | ORAL | ANDA | 23 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4595 | TABLET, FILM COATED, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 30 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4595 | TABLET, FILM COATED, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 30 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4596 | TABLET, FILM COATED, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4596 | TABLET, FILM COATED, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4597 | TABLET, FILM COATED, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 30 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4597 | TABLET, FILM COATED, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 30 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4598 | TABLET, FILM COATED, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 30 sections |
Metoprolol Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4598 | TABLET, FILM COATED, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 30 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1778 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 31 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1778 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 31 sections |
Metoprolol Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2016 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 31 sections |
METOPROLOL SUCCINATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2600 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | NDA authorized generic | 27 sections |
METOPROLOL SUCCINATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2601 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | NDA authorized generic | 27 sections |
METOPROLOL SUCCINATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2602 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA authorized generic | 27 sections |
METOPROLOL SUCCINATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2603 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | NDA authorized generic | 27 sections |