metoprolol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 1786 51384-51-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metoprolol fumarate
  • metoprolol
  • metoprolol succinate
  • beatrolol
  • metoprolol tartrate
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
  • Molecular weight: 267.37
  • Formula: C15H25NO3
  • CLOGP: 1.49
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 50.72
  • ALOGS: -2.82
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 24.95 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 13 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.88 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,ITK,JAK3,MAP2K6,MAPK7,MAPKAPK2,NTRK2,PDK2,PDK4,PRKDC,SIK2,TEK,TGFBR1,ZAP70 29
kinase-selectivity-class PDK4 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.575 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.402 % High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1978 FDA US PHARMS HOLDINGS I

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1511.07 9.64 2004 366366 103968 90156109
Atrial fibrillation 1312.37 9.64 2119 366251 131492 90128585
Cardiac failure congestive 1224.05 9.64 1745 366625 96949 90163128
Pemphigus 1214.60 9.64 23 368347 326841 89933236
Systemic lupus erythematosus 1096.64 9.64 103 368267 361793 89898284
Hand deformity 1084.62 9.64 25 368345 296337 89963740
Completed suicide 1049.95 9.64 2012 366358 143046 90117031
Glossodynia 1043.91 9.64 67 368303 321712 89938365
Synovitis 1017.53 9.64 87 368283 329665 89930412
Anti-cyclic citrullinated peptide antibody positive 941.95 9.64 3 368367 236430 90023647
Bradycardia 917.58 9.64 1398 366972 82449 90177628
Duodenal ulcer perforation 874.88 9.64 4 368366 221284 90038793
Pericarditis 853.60 9.64 64 368306 270087 89989990
Infusion related reaction 821.87 9.64 333 368037 416447 89843630
Helicobacter infection 818.98 9.64 22 368348 226828 90033249
Coronary artery disease 806.36 9.64 831 367539 32792 90227285
Folliculitis 764.48 9.64 13 368357 204340 90055737
Arthropathy 736.12 9.64 284 368086 365958 89894119
Hypotension 731.44 9.64 2936 365434 322461 89937616
BRASH syndrome 703.95 9.64 271 368099 1608 90258469
Contraindicated product administered 679.44 9.64 227 368143 319912 89940165
Rheumatoid factor positive 668.65 9.64 5 368365 171645 90088432
Muscle injury 661.75 9.64 11 368359 176643 90083434
Treatment failure 656.44 9.64 209 368161 303719 89956358
Wound 647.92 9.64 212 368158 302768 89957309
Lower respiratory tract infection 636.87 9.64 123 368247 250536 90009541
Drug intolerance 624.40 9.64 541 367829 447050 89813027
Joint swelling 599.65 9.64 698 367672 502602 89757475
Acute myocardial infarction 596.96 9.64 723 367647 34167 90225910
Irritable bowel syndrome 541.54 9.64 95 368275 207353 90052724
Swelling 496.96 9.64 583 367787 418475 89841602
Hepatic enzyme increased 481.39 9.64 454 367916 360282 89899795
Cerebrovascular accident 476.44 9.64 1338 367032 122195 90137882
Syncope 465.49 9.64 1389 366981 131274 90128803
Hypersensitivity 446.40 9.64 725 367645 453952 89806125
Type 2 diabetes mellitus 441.81 9.64 138 368232 203106 90056971
Fall 425.81 9.64 3380 364990 478430 89781647
C-reactive protein abnormal 417.51 9.64 25 368345 127404 90132673
Cardiac disorder 417.36 9.64 794 367576 56078 90203999
Therapeutic product effect decreased 413.52 9.64 314 368056 277257 89982820
Liver injury 411.95 9.64 94 368276 170473 90089604
Impaired healing 408.92 9.64 221 368149 233978 90026099
Blister 386.87 9.64 283 368087 254715 90005362
Discomfort 378.04 9.64 335 368035 274000 89986077
Ill-defined disorder 376.76 9.64 140 368230 184751 90075326
Death 375.84 9.64 3152 365218 453399 89806678
Product prescribing error 366.03 9.64 528 367842 29617 90230460
Psoriatic arthropathy 361.44 9.64 242 368128 228093 90031984
Facet joint syndrome 360.83 9.64 8 368362 98381 90161696
Alopecia 359.90 9.64 938 367432 494133 89765944
Drug interaction 358.51 9.64 2132 366238 274321 89985756
Suspected suicide 355.99 9.64 302 368068 9266 90250811
Sleep disorder due to general medical condition, insomnia type 353.67 9.64 51 368319 128643 90131434
Rheumatoid arthritis 349.40 9.64 585 367785 362029 89898048
Maternal exposure during pregnancy 347.75 9.64 580 367790 359483 89900594
Cardiogenic shock 341.08 9.64 458 367912 24010 90236067
Lip dry 333.17 9.64 19 368351 100936 90159141
Drug ineffective 327.49 9.64 3831 364539 1380467 88879610
Acute kidney injury 319.35 9.64 2313 366057 318074 89942003
Abdominal discomfort 313.13 9.64 950 367420 476378 89783699
Cardiac failure 309.82 9.64 1065 367305 108431 90151646
Dehydration 304.97 9.64 1579 366791 192868 90067209
Gastrointestinal haemorrhage 295.02 9.64 922 367448 89326 90170751
Dyspnoea 289.42 9.64 5105 363265 875850 89384227
Product use issue 286.73 9.64 567 367803 329352 89930725
Joint range of motion decreased 286.07 9.64 97 368273 135546 90124531
Blood cholesterol increased 284.11 9.64 256 368114 207756 90052321
Inflammation 282.97 9.64 189 368181 178403 90081674
Cardiac arrest 281.63 9.64 1003 367367 103932 90156145
Toxicity to various agents 277.01 9.64 2061 366309 285785 89974292
Dizziness 274.42 9.64 3625 364745 585659 89674418
Renal failure 269.22 9.64 1151 367219 129856 90130221
C-reactive protein increased 268.99 9.64 206 368164 181183 90078894
Mobility decreased 265.80 9.64 379 367991 250355 90009722
Grip strength decreased 265.58 9.64 32 368338 92544 90167533
Stomatitis 263.72 9.64 444 367926 274254 89985823
Palpitations 262.51 9.64 1177 367193 135551 90124526
Wound infection 256.15 9.64 59 368311 106343 90153734
Musculoskeletal stiffness 251.33 9.64 517 367853 296015 89964062
Off label use 250.99 9.64 3074 365296 1099178 89160899
Fibromyalgia 245.22 9.64 286 368084 205983 90054094
Bursitis 232.98 9.64 122 368248 131532 90128545
Product monitoring error 230.30 9.64 172 368198 4372 90255705
Gastrointestinal disorder 224.80 9.64 439 367931 256248 90003829
Arrhythmia 221.82 9.64 515 367855 41817 90218260
Injury 220.53 9.64 287 368083 197062 90063015
Sinus bradycardia 217.70 9.64 305 368065 16647 90243430
Adjustment disorder with depressed mood 214.72 9.64 3 368367 56750 90203327
Hypercholesterolaemia 211.25 9.64 73 368297 100819 90159258
Coronary artery bypass 211.23 9.64 127 368243 2222 90257855
Pyrexia 210.12 9.64 1698 366672 658787 89601290
International normalised ratio increased 209.98 9.64 540 367830 46776 90213301
Infection 206.88 9.64 765 367605 361329 89898748
Sinusitis 203.18 9.64 714 367656 342374 89917703
Peripheral venous disease 203.06 9.64 46 368324 83875 90176202
Pain 199.35 9.64 2853 365517 993488 89266589
Blood pressure increased 196.37 9.64 1424 366946 195793 90064284
Rash 195.15 9.64 2183 366187 793917 89466160
Anaemia 190.37 9.64 2232 366138 350570 89909507
Urticaria 185.71 9.64 650 367720 312084 89947993
Haemoglobin decreased 184.05 9.64 1208 367162 160748 90099329
Hyperkalaemia 180.33 9.64 628 367742 64336 90195741
Autoimmune disorder 179.91 9.64 45 368325 76699 90183378
Anti-neutrophil cytoplasmic antibody positive vasculitis 175.77 9.64 139 368231 3854 90256223
Sleep disorder 174.80 9.64 337 368033 197693 90062384
Angina pectoris 173.85 9.64 447 367923 38713 90221364
Blepharospasm 172.52 9.64 14 368356 55431 90204646
Lung disorder 169.46 9.64 216 368154 149667 90110410
Labelled drug-drug interaction medication error 169.16 9.64 250 368120 14332 90245745
Red blood cell sedimentation rate increased 169.09 9.64 62 368308 82533 90177544
Intentional product use issue 168.18 9.64 397 367973 216495 90043582
Ventricular tachycardia 167.87 9.64 334 368036 24374 90235703
Pregnancy 167.19 9.64 26 368344 62021 90198056
Sensitisation 166.12 9.64 137 368233 4038 90256039
Pulmonary fibrosis 165.93 9.64 117 368253 107386 90152691
Angina unstable 164.84 9.64 173 368197 6970 90253107
Pulmonary oedema 163.62 9.64 590 367780 61490 90198587
Lactic acidosis 163.44 9.64 514 367856 49949 90210128
Drug hypersensitivity 163.27 9.64 1158 367212 462451 89797626
Urinary tract infection 163.23 9.64 1930 366440 303702 89956375
Wheezing 160.79 9.64 467 367903 237613 90022464
Bone erosion 160.59 9.64 15 368355 53006 90207071
Hyponatraemia 160.29 9.64 1010 367360 132528 90127549
Prescribed overdose 159.10 9.64 100 368270 97525 90162552
Coronary arterial stent insertion 158.63 9.64 114 368256 2726 90257351
Ejection fraction 157.14 9.64 116 368254 2895 90257182
Hip arthroplasty 156.36 9.64 57 368313 76151 90183926
Live birth 154.32 9.64 64 368306 79043 90181034
Nasopharyngitis 148.66 9.64 1006 367364 406098 89853979
Diarrhoea 147.45 9.64 4920 363450 934270 89325807
Blood creatinine increased 145.65 9.64 804 367566 100582 90159495
Night sweats 143.05 9.64 188 368182 128578 90131499
Lower limb fracture 142.84 9.64 84 368286 84929 90175148
Obesity 140.26 9.64 133 368237 105374 90154703
Renal impairment 139.61 9.64 818 367552 104603 90155474
Onychomadesis 136.72 9.64 14 368356 45984 90214093
Epilepsy 134.24 9.64 84 368286 82122 90177955
Polycystic ovaries 134.17 9.64 139 368231 5515 90254562
Hypertensive crisis 133.78 9.64 251 368119 17533 90242544
Road traffic accident 131.36 9.64 146 368224 107480 90152597
Product dose omission issue 128.19 9.64 1777 366593 289910 89970167
Migraine 128.13 9.64 374 367996 190018 90070059
Renal disorder 127.57 9.64 391 367979 37468 90222609
Asthenia 125.04 9.64 2944 365426 530807 89729270
Rhabdomyolysis 123.26 9.64 473 367897 50783 90209294
Oedema peripheral 122.28 9.64 1593 366777 256322 90003755
Mental status changes 118.90 9.64 426 367944 44253 90215824
Plasma cell myeloma 117.94 9.64 400 367970 40428 90219649
Atrioventricular block complete 117.85 9.64 171 368199 9640 90250437
Blood pressure decreased 117.83 9.64 609 367761 74286 90185791
Exposure during pregnancy 117.08 9.64 534 367836 237876 90022201
Atrioventricular block 116.77 9.64 161 368209 8654 90251423
Unresponsive to stimuli 115.91 9.64 380 367990 37741 90222336
Nail disorder 114.87 9.64 48 368322 59019 90201058
Haematochezia 114.62 9.64 581 367789 70332 90189745
Sciatica 113.65 9.64 147 368223 101235 90158842
Gait inability 113.55 9.64 268 368102 146188 90113889
Dyspnoea exertional 113.17 9.64 587 367783 71701 90188376
Arthralgia 111.62 9.64 2365 366005 776157 89483920
Heart rate increased 111.02 9.64 813 367557 112089 90147988
Coeliac disease 110.87 9.64 23 368347 44587 90215490
Chronic kidney disease 110.08 9.64 450 367920 49741 90210336
Acute coronary syndrome 109.40 9.64 174 368196 10639 90249438
Blood loss anaemia 109.30 9.64 168 368202 9972 90250105
Hypoaesthesia 108.96 9.64 788 367582 313422 89946655
Atrial flutter 107.31 9.64 172 368198 10586 90249491
Weight increased 105.66 9.64 1137 367233 416790 89843287
Product substitution issue 103.15 9.64 227 368143 17781 90242296
Pulmonary hypertension 102.73 9.64 393 367977 42130 90217947
Transient ischaemic attack 101.83 9.64 396 367974 42780 90217297
Thrombosis 100.63 9.64 574 367796 72677 90187400
Pulmonary renal syndrome 98.62 9.64 48 368322 537 90259540
Heart rate irregular 97.55 9.64 267 368103 24001 90236076
Exostosis 97.33 9.64 47 368323 53087 90206990
Hypoglycaemia 97.04 9.64 549 367821 69299 90190778
Atrioventricular block first degree 95.97 9.64 144 368226 8367 90251710
Blood test abnormal 95.94 9.64 242 368128 20710 90239367
Presyncope 94.87 9.64 315 368055 31490 90228587
Condition aggravated 92.77 9.64 1784 366586 593761 89666316
Mitral valve incompetence 92.73 9.64 250 368120 22274 90237803
Blood pressure inadequately controlled 92.12 9.64 120 368250 6104 90253973
Lupus-like syndrome 91.33 9.64 42 368328 48804 90211273
Colitis ulcerative 91.14 9.64 67 368303 60199 90199878
Sleep apnoea syndrome 90.79 9.64 310 368060 31437 90228640
Myocardial ischaemia 90.57 9.64 184 368186 13630 90246447
Therapy non-responder 89.46 9.64 272 368098 136432 90123645
Osteoarthritis 89.32 9.64 450 367920 195280 90064797
Gout 89.29 9.64 206 368164 16653 90243424
Product administration error 89.12 9.64 273 368097 26150 90233927
Hypokalaemia 88.49 9.64 868 367502 130248 90129829
Deep vein thrombosis 87.37 9.64 655 367715 90965 90169112
Liver disorder 86.93 9.64 231 368139 121038 90139039
Knee arthroplasty 86.81 9.64 127 368243 83055 90177022
Hiatus hernia 86.45 9.64 263 368107 25098 90234979
Coronary artery occlusion 85.65 9.64 137 368233 8417 90251660
Ventricular extrasystoles 85.11 9.64 175 368195 13075 90247002
Prescribed underdose 84.88 9.64 108 368262 74911 90185166
Nodal rhythm 83.73 9.64 65 368305 1753 90258324
Cardio-respiratory arrest 83.61 9.64 490 367880 62650 90197427
Drug tolerance decreased 83.15 9.64 15 368355 32115 90227962
Ventricular fibrillation 82.68 9.64 179 368191 13865 90246212
Hypertensive emergency 82.52 9.64 70 368300 2147 90257930
Heart rate decreased 81.35 9.64 431 367939 53074 90207003
Cerebral haemorrhage 80.90 9.64 316 368054 34206 90225871
Onychomycosis 80.04 9.64 26 368344 37350 90222727
Product label confusion 79.59 9.64 3 368367 22847 90237230
Epistaxis 79.16 9.64 605 367765 84520 90175557
Haematoma 77.78 9.64 340 368030 38708 90221369
Hepatic cytolysis 76.70 9.64 16 368354 30900 90229177
Product use in unapproved indication 75.87 9.64 938 367432 335298 89924779
Hepatitis 75.80 9.64 106 368264 70633 90189444
Back injury 75.62 9.64 48 368322 46574 90213503
Loss of employment 75.54 9.64 76 368294 2911 90257166
Torsade de pointes 75.50 9.64 181 368189 15001 90245076
Myelosuppression 75.47 9.64 64 368306 53527 90206550
Acute respiratory failure 75.31 9.64 360 368010 42558 90217519
Full blood count decreased 73.87 9.64 277 368093 29412 90230665
Dry mouth 73.65 9.64 442 367928 183617 90076460
Blood glucose increased 73.54 9.64 649 367721 94597 90165480
Chest pain 72.54 9.64 1756 366614 317889 89942188
Blood potassium decreased 72.25 9.64 384 367986 47343 90212734
Ejection fraction abnormal 71.64 9.64 68 368302 2423 90257654
Hip fracture 71.30 9.64 295 368075 32782 90227295
Hypervolaemia 71.28 9.64 293 368077 32464 90227613
Feeling abnormal 71.04 9.64 1013 367357 166222 90093855
Taste disorder 70.26 9.64 88 368282 61458 90198619
Supraventricular tachycardia 69.96 9.64 184 368186 16152 90243925
Cardiomegaly 68.05 9.64 200 368170 18725 90241352
Cardiac failure acute 67.90 9.64 150 368220 11779 90248298
Red blood cell sedimentation rate abnormal 67.87 9.64 9 368361 24195 90235882
Tachyarrhythmia 67.54 9.64 96 368274 5310 90254767
Ischaemic stroke 67.42 9.64 221 368149 21945 90238132
Laryngitis 67.41 9.64 64 368306 50689 90209388
Pleural effusion 67.27 9.64 724 367646 111267 90148810
Arterial haemorrhage 67.14 9.64 66 368304 2457 90257620
Hypomagnesaemia 66.47 9.64 304 368066 35284 90224793
Foot deformity 66.32 9.64 87 368283 59564 90200513
Carpal tunnel syndrome 66.11 9.64 231 368139 23697 90236380
Orthostatic intolerance 65.84 9.64 50 368320 1304 90258773
Congenital hydronephrosis 65.28 9.64 33 368337 403 90259674
Shock 64.68 9.64 260 368110 28518 90231559
Sinus node dysfunction 64.53 9.64 94 368276 5318 90254759
Frequent bowel movements 64.37 9.64 82 368288 56853 90203224
Lower gastrointestinal haemorrhage 63.79 9.64 123 368247 8769 90251308
Hepatic cirrhosis 63.65 9.64 99 368271 63154 90196923
Peripheral arterial occlusive disease 63.63 9.64 86 368284 4535 90255542
Blood urea increased 63.02 9.64 268 368102 30145 90229932
Dyspepsia 62.96 9.64 509 367861 197651 90062426
Haematuria 62.72 9.64 295 368075 34642 90225435
Dementia 62.20 9.64 226 368144 23635 90236442
Coronary artery stenosis 62.11 9.64 91 368279 5175 90254902
Nephrogenic systemic fibrosis 62.05 9.64 80 368290 4028 90256049
Asthma 61.45 9.64 658 367712 241502 90018575
Cardiovascular disorder 60.90 9.64 155 368215 13337 90246740
Haemorrhage 60.62 9.64 486 367884 68883 90191194
Therapeutic drug monitoring analysis not performed 60.08 9.64 47 368323 1282 90258795
Rhinitis allergic 59.98 9.64 177 368193 16608 90243469
Febrile neutropenia 59.85 9.64 387 367983 157962 90102115
Tachycardia 59.53 9.64 936 367434 156737 90103340
Immunodeficiency 59.22 9.64 53 368317 43181 90216896
Device expulsion 58.59 9.64 48 368322 40838 90219239
Hypothyroidism 58.31 9.64 393 367977 52734 90207343
Melaena 58.27 9.64 288 368082 34509 90225568
Respiratory failure 57.98 9.64 736 367634 117682 90142395
Body height decreased 57.86 9.64 141 368229 11808 90248269
Metabolic acidosis 57.65 9.64 406 367964 55270 90204807
Urinary retention 57.35 9.64 304 368066 37440 90222637
Sepsis 57.14 9.64 1038 367332 178776 90081301
Atrioventricular block second degree 57.01 9.64 80 368290 4372 90255705
Nephrectomy 56.82 9.64 54 368316 1927 90258150
Incorrect route of product administration 56.12 9.64 74 368296 50552 90209525
Disability 55.75 9.64 50 368320 40695 90219382
Seronegative arthritis 55.64 9.64 5 368365 18229 90241848
Chronic obstructive pulmonary disease 55.41 9.64 500 367870 73329 90186748
Hypovolaemia 55.27 9.64 142 368228 12289 90247788
Head injury 55.00 9.64 262 368108 30926 90229151
Ear infection 54.61 9.64 127 368243 69648 90190429
Abortion spontaneous 54.02 9.64 85 368285 53971 90206106
Nausea 53.97 9.64 5224 363146 1105092 89154985
Liver function test increased 53.97 9.64 171 368199 84684 90175393
Hyperlipidaemia 53.07 9.64 209 368161 22707 90237370
Vascular graft 51.72 9.64 36 368334 817 90259260
Therapeutic product effect incomplete 51.57 9.64 521 367849 193375 90066702
Body mass index abnormal 51.51 9.64 34 368336 705 90259372
Drug resistance 51.26 9.64 30 368340 30419 90229658
Heart rate abnormal 50.92 9.64 89 368281 5882 90254195
Muscle spasticity 49.96 9.64 42 368328 35280 90224797
Oedema 49.70 9.64 547 367823 199748 90060329
Aortic valve stenosis 49.62 9.64 73 368297 4167 90255910
Myalgia 49.50 9.64 993 367377 174132 90085945
Unevaluable event 49.42 9.64 387 367983 54461 90205616
Arteriosclerosis coronary artery 49.39 9.64 116 368254 9487 90250590
Arteriosclerosis 49.32 9.64 125 368245 10728 90249349
Cardiomyopathy 49.01 9.64 187 368183 20019 90240058
Anuria 48.95 9.64 152 368218 14666 90245411
Diverticulum intestinal 48.74 9.64 112 368258 9030 90251047
Eructation 48.07 9.64 124 368246 10758 90249319
Hypothermia 48.01 9.64 156 368214 15419 90244658
Ischaemic hepatitis 47.95 9.64 58 368312 2735 90257342
Adverse reaction 47.62 9.64 31 368339 29681 90230396
Renal injury 47.62 9.64 119 368251 10124 90249953
Loss of consciousness 47.56 9.64 818 367552 139420 90120657
Maternal exposure timing unspecified 47.51 9.64 16 368354 22467 90237610
Ventricular arrhythmia 47.15 9.64 72 368298 4249 90255828
Listless 47.09 9.64 62 368308 3187 90256890
Bundle branch block left 46.99 9.64 101 368269 7784 90252293
Injection site reaction 46.51 9.64 204 368166 91876 90168201
Ventricular hypokinesia 46.06 9.64 80 368290 5261 90254816
Conjoined twins 45.97 9.64 28 368342 502 90259575
Electrolyte imbalance 45.96 9.64 205 368165 23540 90236537
Nephropathy 45.81 9.64 110 368260 9125 90250952
Patent ductus arteriosus 45.50 9.64 73 368297 4496 90255581
Circulatory collapse 45.22 9.64 211 368159 24693 90235384
Female genital tract fistula 44.84 9.64 9 368361 17859 90242218
Orthopnoea 44.76 9.64 91 368279 6744 90253333
HELLP syndrome 44.43 9.64 38 368332 1179 90258898
Neonatal respiratory failure 44.37 9.64 23 368347 297 90259780
Body tinea 44.26 9.64 49 368321 2099 90257978
Hypersensitivity myocarditis 43.85 9.64 22 368348 264 90259813
Adverse event 43.84 9.64 288 368082 117130 90142947
Joint stiffness 43.74 9.64 166 368204 77876 90182201
Bradyarrhythmia 43.72 9.64 52 368318 2409 90257668
Encephalopathy 43.68 9.64 331 368039 46113 90213964
Electrocardiogram QRS complex prolonged 43.65 9.64 94 368276 7254 90252823
Coagulopathy 43.53 9.64 199 368171 23090 90236987
Left ventricular dysfunction 43.49 9.64 145 368225 14524 90245553
Hyperglycaemia 43.39 9.64 355 368015 50615 90209462
Cardiac pacemaker insertion 43.33 9.64 70 368300 4337 90255740
Burning sensation 43.25 9.64 421 367949 63031 90197046
Musculoskeletal pain 42.75 9.64 467 367903 170784 90089293
Vaginal discharge 42.64 9.64 13 368357 19451 90240626
Interstitial lung disease 42.51 9.64 163 368207 76242 90183835
Drug level increased 42.45 9.64 224 368146 27538 90232539
Intestinal malrotation 42.41 9.64 25 368345 421 90259656
Haemorrhoidal haemorrhage 42.39 9.64 77 368293 5246 90254831
Drug reaction with eosinophilia and systemic symptoms 42.00 9.64 68 368302 42690 90217387
Aortic valve incompetence 41.97 9.64 87 368283 6537 90253540
Pallor 41.95 9.64 260 368110 33905 90226172
Cardiac output decreased 41.69 9.64 34 368336 986 90259091
Ageusia 41.68 9.64 152 368218 15924 90244153
Glucose tolerance impaired 41.66 9.64 97 368273 7888 90252189
Extrasystoles 41.50 9.64 79 368291 5578 90254499
Haemarthrosis 41.41 9.64 65 368305 3929 90256148
Medication error 41.38 9.64 526 367844 84126 90175951
Upper gastrointestinal haemorrhage 41.23 9.64 194 368176 22782 90237295
Ischaemic cardiomyopathy 41.22 9.64 52 368318 2561 90257516
Infusion site reaction 41.20 9.64 13 368357 19026 90241051
Internal haemorrhage 40.95 9.64 83 368287 6137 90253940
Skin induration 40.86 9.64 58 368312 3204 90256873
Hypertensive heart disease 40.80 9.64 52 368318 2588 90257489
Glomerular filtration rate decreased 40.49 9.64 156 368214 16776 90243301
Fear 40.45 9.64 154 368216 16468 90243609
Subarachnoid haemorrhage 40.43 9.64 162 368208 17742 90242335
Acute left ventricular failure 40.39 9.64 37 368333 1259 90258818
Walking aid user 40.28 9.64 51 368319 35455 90224622
Cerebral infarction 40.26 9.64 214 368156 26382 90233695
Pulmonary embolism 40.09 9.64 751 367619 130069 90130008
Hypoacusis 40.07 9.64 221 368149 27629 90232448
Decorticate posture 39.97 9.64 22 368348 323 90259754
Drug-induced liver injury 39.85 9.64 210 368160 90108 90169969
Rheumatoid nodule 39.83 9.64 16 368354 20150 90239927
Finger deformity 39.72 9.64 45 368325 32852 90227225
Stress cardiomyopathy 39.59 9.64 132 368238 13223 90246854
Hospice care 39.23 9.64 107 368263 9597 90250480
Flatulence 39.00 9.64 295 368075 41072 90219005
Hypoxia 38.91 9.64 458 367912 71941 90188136
Blood magnesium decreased 38.69 9.64 146 368224 15547 90244530
Respiratory disorder 38.21 9.64 135 368235 64681 90195396
Cough 38.01 9.64 1849 366521 367113 89892964
Serositis 37.97 9.64 36 368334 1281 90258796
Wrong product administered 37.70 9.64 91 368279 7574 90252503
Pulseless electrical activity 37.63 9.64 100 368270 8832 90251245
Respiratory arrest 37.51 9.64 248 368122 33063 90227014
Congenital aortic valve stenosis 37.15 9.64 13 368357 56 90260021
Blood potassium increased 37.09 9.64 175 368195 20574 90239503
Dysphagia 37.02 9.64 652 367718 111626 90148451
Blood sodium decreased 37.01 9.64 215 368155 27398 90232679
Contusion 36.75 9.64 760 367610 250456 90009621
Atrial septal defect 36.55 9.64 94 368276 8140 90251937
Nodal arrhythmia 36.39 9.64 35 368335 1268 90258809
Inhibitory drug interaction 36.36 9.64 54 368316 3109 90256968
Stent placement 36.30 9.64 63 368307 4140 90255937
Phaeochromocytoma crisis 35.71 9.64 21 368349 352 90259725
Femoral hernia incarcerated 35.65 9.64 37 368333 1471 90258606
Blindness transient 35.27 9.64 65 368305 4478 90255599
Device capturing issue 35.25 9.64 11 368359 30 90260047
Hallucination 34.89 9.64 416 367954 65543 90194534
Haemorrhage intracranial 34.88 9.64 138 368232 15024 90245053
Joint destruction 34.83 9.64 6 368364 13281 90246796
Panniculitis 34.82 9.64 8 368362 14450 90245627
Lymphatic fistula 34.81 9.64 36 368334 1425 90258652
Pustular psoriasis 34.62 9.64 16 368354 18540 90241537
Blood creatine increased 34.58 9.64 83 368287 6884 90253193
Sudden cardiac death 34.55 9.64 44 368326 2188 90257889
Myocardial depression 34.42 9.64 25 368345 608 90259469
Diverticulitis 34.40 9.64 307 368063 44880 90215197
Aortic arteriosclerosis 34.39 9.64 88 368282 7596 90252481
Essential hypertension 34.37 9.64 78 368292 6237 90253840
Electrocardiogram abnormal 34.36 9.64 106 368264 10192 90249885
Diverticulum intestinal haemorrhagic 34.28 9.64 39 368331 1722 90258355
Aortic stenosis 34.19 9.64 78 368292 6258 90253819
Cellulitis 34.00 9.64 541 367829 90796 90169281
Food allergy 33.99 9.64 32 368338 25446 90234631
Electrocardiogram T wave abnormal 33.97 9.64 48 368322 2640 90257437
Proctitis 33.78 9.64 10 368360 15249 90244828
Amnesia 33.40 9.64 281 368089 108224 90151853
Bicuspid aortic valve 33.27 9.64 15 368355 139 90259938
Coronary artery dissection 33.23 9.64 29 368341 925 90259152
Electrocardiogram QT prolonged 33.22 9.64 445 367925 72011 90188066
Confusional state 33.15 9.64 1259 367111 384946 89875131
Initial insomnia 33.10 9.64 98 368272 9212 90250865
Glomerulonephritis rapidly progressive 32.95 9.64 33 368337 1257 90258820
Heparin-induced thrombocytopenia 32.76 9.64 69 368301 5243 90254834
Dysgeusia 32.58 9.64 342 368028 52218 90207859
Faeces discoloured 32.58 9.64 172 368198 21148 90238929
Granuloma skin 32.40 9.64 3 368367 10677 90249400
Bronchiectasis 32.27 9.64 26 368344 22304 90237773
Drug abuse 32.26 9.64 199 368171 82148 90177929
Urosepsis 32.25 9.64 171 368199 21061 90239016
Supraventricular extrasystoles 32.09 9.64 68 368302 5189 90254888
Tricuspid valve incompetence 32.05 9.64 144 368226 16587 90243490
Abortion induced 31.98 9.64 5 368365 11883 90248194
Occult blood positive 31.79 9.64 58 368312 3965 90256112
Blood pressure abnormal 31.76 9.64 161 368209 19484 90240593
Mitral valve stenosis 31.51 9.64 33 368337 1326 90258751
Pancreatic steatosis 31.35 9.64 36 368334 1606 90258471
Embolic stroke 31.29 9.64 58 368312 4014 90256063
Drug tolerance 31.09 9.64 17 368353 17899 90242178
International normalised ratio decreased 31.06 9.64 63 368307 4661 90255416
Venous pressure jugular increased 31.05 9.64 23 368347 577 90259500
Poor quality sleep 31.00 9.64 189 368181 24504 90235573
Dialysis 30.98 9.64 109 368261 11220 90248857
Cardioactive drug level increased 30.77 9.64 43 368327 2341 90257736
Post procedural haemorrhage 30.70 9.64 92 368278 8706 90251371
Ischaemic contracture of the left ventricle 30.66 9.64 14 368356 134 90259943
Tooth disorder 30.61 9.64 224 368146 30866 90229211
Nervousness 30.51 9.64 240 368130 33816 90226261
Angioedema 30.39 9.64 400 367970 64476 90195601
Product solubility abnormal 30.37 9.64 28 368342 961 90259116
Product residue present 30.35 9.64 59 368311 4232 90255845
Subdural haematoma 30.20 9.64 141 368229 16504 90243573
Tremor 30.16 9.64 826 367544 152347 90107730
Chromaturia 30.15 9.64 156 368214 19031 90241046
Spondylitis 30.12 9.64 10 368360 14168 90245909
Thyrotoxic myopathy 30.08 9.64 8 368362 9 90260068
Monoclonal immunoglobulin present 29.97 9.64 40 368330 2084 90257993
Metabolic encephalopathy 29.88 9.64 77 368293 6675 90253402
International normalised ratio abnormal 29.83 9.64 55 368315 3790 90256287
Blood cholesterol decreased 29.79 9.64 38 368332 1893 90258184
Personality disorder 29.74 9.64 7 368363 12437 90247640
Small for dates baby 29.68 9.64 64 368306 4943 90255134
Cardioversion 29.53 9.64 32 368338 1338 90258739
Labile hypertension 29.52 9.64 21 368349 494 90259583
Lethargy 29.45 9.64 389 367981 62750 90197327
Haemophagocytic lymphohistiocytosis 29.36 9.64 13 368357 15446 90244631
Chronic sinusitis 29.35 9.64 32 368338 23770 90236307
Limb injury 29.32 9.64 224 368146 31284 90228793
Hepatic cyst 29.17 9.64 75 368295 6493 90253584
Hepatic steatosis 29.16 9.64 253 368117 36692 90223385
Hypotonia 28.75 9.64 107 368263 11319 90248758
Cervicogenic headache 28.72 9.64 15 368355 197 90259880
Cardiac ablation 28.63 9.64 35 368335 1669 90258408
Hallucination, visual 28.52 9.64 176 368194 22916 90237161
Prothrombin time prolonged 28.44 9.64 96 368274 9676 90250401
Ear pain 28.44 9.64 129 368241 57573 90202504
Haemoptysis 28.32 9.64 232 368138 33088 90226989
Therapeutic response decreased 28.24 9.64 231 368139 89498 90170579
Neutropenia 28.18 9.64 697 367673 224207 90035870
Paraesthesia 28.15 9.64 788 367582 249538 90010539
Poisoning deliberate 28.10 9.64 16 368354 16470 90243607
Haemodynamic instability 27.94 9.64 108 368262 11631 90248446
Anhedonia 27.90 9.64 106 368264 11325 90248752
Infection susceptibility increased 27.79 9.64 54 368316 3872 90256205
Haematemesis 27.69 9.64 233 368137 33493 90226584
Schizophrenia 27.61 9.64 13 368357 14901 90245176
Fibrosis 27.51 9.64 69 368301 5883 90254194
Troponin increased 27.49 9.64 117 368253 13164 90246913
Maternal exposure before pregnancy 27.41 9.64 6 368364 11207 90248870
Congenital bladder anomaly 27.38 9.64 15 368355 218 90259859
Myocardial hypoxia 27.35 9.64 8 368362 16 90260061
Haemodialysis 27.31 9.64 88 368282 8659 90251418
Aortic aneurysm 27.18 9.64 57 368313 4318 90255759
Non-cardiogenic pulmonary oedema 27.10 9.64 29 368341 1195 90258882
Arteriospasm coronary 27.07 9.64 62 368308 4988 90255089
Alveolitis 27.04 9.64 46 368324 2975 90257102
Urachal abnormality 26.91 9.64 15 368355 226 90259851
Wound infection pseudomonas 26.87 9.64 37 368333 1986 90258091
Adverse drug reaction 26.87 9.64 324 368046 116377 90143700
Vision blurred 26.83 9.64 612 367758 109681 90150396
Gouty arthritis 26.78 9.64 21 368349 575 90259502
Intraventricular haemorrhage 26.74 9.64 41 368329 2428 90257649
Sedation complication 26.72 9.64 18 368352 16926 90243151
Sinus arrest 26.65 9.64 38 368332 2108 90257969
Dyslipidaemia 26.57 9.64 96 368274 10011 90250066
End stage renal disease 26.56 9.64 86 368284 8485 90251592
Gastritis 26.50 9.64 273 368097 41480 90218597
Erythema 26.46 9.64 719 367651 228527 90031550
Myxoedema coma 26.42 9.64 18 368352 394 90259683
Cytomegalovirus infection 26.42 9.64 42 368328 26560 90233517
Vitello-intestinal duct remnant 26.25 9.64 9 368361 36 90260041
Acidosis 26.21 9.64 112 368258 12624 90247453
Persistent cloaca 26.18 9.64 15 368355 239 90259838
Phaeochromocytoma 26.14 9.64 21 368349 596 90259481
Sinus tachycardia 26.13 9.64 202 368168 28311 90231766
Splenic rupture 26.07 9.64 30 368340 1341 90258736
Cardiac valve disease 26.06 9.64 58 368312 4577 90255500
Cardiorenal syndrome 25.78 9.64 27 368343 1085 90258992
Diabetes mellitus 25.57 9.64 388 367982 64487 90195590
Localised infection 25.54 9.64 228 368142 33334 90226743
Pseudolymphoma 25.46 9.64 21 368349 619 90259458
Seroma 25.31 9.64 45 368325 3015 90257062
Blood parathyroid hormone decreased 25.29 9.64 9 368361 12207 90247870
Cardiac operation 25.18 9.64 52 368318 3897 90256180
Rectourethral fistula 25.08 9.64 8 368362 24 90260053
Congenital ureterocele 25.08 9.64 8 368362 24 90260053
Foreign body 25.05 9.64 40 368330 2454 90257623
Anaphylactic reaction 25.02 9.64 231 368139 87293 90172784
Hepatic function abnormal 24.95 9.64 100 368270 46188 90213889
Drug eruption 24.94 9.64 68 368302 35339 90224738
Blood glucose decreased 24.92 9.64 172 368198 23257 90236820
Myocardial necrosis marker increased 24.77 9.64 37 368333 2141 90257936
Vascular resistance pulmonary decreased 24.59 9.64 10 368360 70 90260007
Eye haemorrhage 24.51 9.64 94 368276 10086 90249991
Paraesthesia oral 24.47 9.64 58 368312 31601 90228476
Clostridium test positive 24.33 9.64 62 368308 5339 90254738
Cataract 24.25 9.64 420 367950 71672 90188405
Electrocardiogram T wave inversion 24.07 9.64 49 368321 3634 90256443
Full blood count abnormal 24.05 9.64 241 368129 36356 90223721
Subchondral insufficiency fracture 24.02 9.64 9 368361 49 90260028
Echocardiogram abnormal 23.93 9.64 31 368339 1568 90258509
Gastritis erosive 23.92 9.64 71 368299 6684 90253393
Macular degeneration 23.80 9.64 77 368293 37893 90222184
Head discomfort 23.76 9.64 130 368240 16203 90243874
Dry skin 23.75 9.64 496 367874 87577 90172500
Blue toe syndrome 23.75 9.64 18 368352 468 90259609
Haemorrhagic stroke 23.69 9.64 69 368301 6427 90253650
Skin discolouration 23.66 9.64 280 368090 44035 90216042
Dermatitis atopic 23.62 9.64 170 368200 23302 90236775
Gastrointestinal tract mucosal pigmentation 23.59 9.64 21 368349 688 90259389
Skin hypertrophy 23.56 9.64 48 368322 3562 90256515
Procedural pain 23.55 9.64 64 368306 33296 90226781
Gastric ulcer 23.27 9.64 191 368179 27257 90232820
Pineal gland cyst 23.26 9.64 13 368357 197 90259880
Cerebrospinal fluid retention 23.13 9.64 10 368360 83 90259994
Left ventricular hypertrophy 23.12 9.64 66 368304 6078 90253999
Kyphosis 23.07 9.64 42 368328 2866 90257211
Hospitalisation 23.06 9.64 683 367687 127417 90132660
Pericardial haemorrhage 22.97 9.64 33 368337 1843 90258234
Foetal growth restriction 22.91 9.64 87 368283 9293 90250784
Carotid artery stenosis 22.76 9.64 60 368310 5274 90254803
Pulse absent 22.74 9.64 65 368305 5990 90254087
Mucosal inflammation 22.71 9.64 139 368231 57486 90202591
Device stimulation issue 22.63 9.64 9 368361 59 90260018
Extra dose administered 22.62 9.64 85 368285 9033 90251044
Sopor 22.55 9.64 41 368329 24603 90235474
Fryns syndrome 22.50 9.64 9 368361 60 90260017
Gastric polyps 22.48 9.64 55 368315 4617 90255460
Eye irritation 22.45 9.64 224 368146 33754 90226323
Fluid retention 22.43 9.64 492 367878 87599 90172478
Acute generalised exanthematous pustulosis 22.37 9.64 14 368356 13689 90246388
Wound dehiscence 22.35 9.64 63 368307 5759 90254318
Fatigue 22.27 9.64 5152 363218 1148871 89111206
Polyarthritis 22.26 9.64 25 368345 18325 90241752
Embolic cerebral infarction 22.25 9.64 19 368351 588 90259489
Ischaemic cerebral infarction 22.23 9.64 29 368341 1477 90258600
Neuroglycopenia 22.23 9.64 25 368345 1090 90258987
Aortic valve sclerosis 22.21 9.64 26 368344 1184 90258893
Congenital choroid plexus cyst 22.19 9.64 15 368355 324 90259753
Congenital acrochordon 22.07 9.64 8 368362 39 90260038
Carotid artery thrombosis 21.96 9.64 5 368365 9087 90250990
Constipation 21.92 9.64 1370 367000 279025 89981052
Peritonitis bacterial 21.89 9.64 58 368312 5113 90254964
Rash vesicular 21.85 9.64 25 368345 18172 90241905
Craniofacial fracture 21.85 9.64 17 368353 460 90259617
Subdural haemorrhage 21.74 9.64 45 368325 3378 90256699
Cytomegalovirus infection reactivation 21.63 9.64 3 368367 7797 90252280
Renal cyst 21.55 9.64 107 368263 12843 90247234
Peripheral swelling 21.54 9.64 1418 366952 411688 89848389
Malignant polyp 21.46 9.64 12 368358 182 90259895
Conjunctival haemorrhage 21.45 9.64 49 368321 3935 90256142
Hyperhidrosis 21.44 9.64 715 367655 135590 90124487
Platelet count decreased 21.42 9.64 718 367652 136251 90123826
Product administration interrupted 21.35 9.64 104 368266 12388 90247689
Ulcer haemorrhage 21.33 9.64 47 368323 26274 90233803
Peripheral vascular disorder 21.27 9.64 66 368304 6365 90253712
Respiratory distress 21.20 9.64 247 368123 38699 90221378
Hepatotoxicity 21.12 9.64 105 368265 45737 90214340
Back pain 21.12 9.64 1529 366841 315646 89944431
Groin pain 21.10 9.64 102 368268 12111 90247966
Intentional overdose 21.09 9.64 515 367855 93319 90166758
Purpura 21.08 9.64 117 368253 14661 90245416
Emotional distress 21.08 9.64 235 368135 36427 90223650
Retroperitoneal haematoma 21.06 9.64 44 368326 3324 90256753
Lacunar infarction 20.98 9.64 44 368326 3333 90256744
Skin disorder 20.97 9.64 235 368135 36471 90223606
Arteriovenous fistula occlusion 20.97 9.64 15 368355 356 90259721
Rebound tachycardia 20.85 9.64 6 368364 11 90260066
Peripheral circulatory failure 20.80 9.64 29 368341 1575 90258502
Ultrasound kidney abnormal 20.57 9.64 8 368362 49 90260028
Infective pulmonary exacerbation of cystic fibrosis 20.56 9.64 8 368362 10271 90249806
Intestinal ischaemia 20.56 9.64 81 368289 8802 90251275
Multiple organ dysfunction syndrome 20.48 9.64 391 367979 67945 90192132
Reduced facial expression 20.42 9.64 37 368333 2516 90257561
Stillbirth 20.32 9.64 3 368367 7440 90252637
Hypertensive urgency 20.25 9.64 19 368351 667 90259410
Pericardial effusion 20.23 9.64 234 368136 36599 90223478
Electrocardiogram RR interval prolonged 20.21 9.64 5 368365 3 90260074
Carbuncle 20.19 9.64 27 368343 1409 90258668
Dysuria 20.18 9.64 247 368123 39154 90220923
Breast cancer stage I 20.08 9.64 7 368363 9617 90250460
Pelvic fracture 20.07 9.64 118 368252 15101 90244976
Hypophagia 20.05 9.64 229 368141 35708 90224369
Hypovolaemic shock 20.04 9.64 69 368301 7025 90253052
Intestinal haemorrhage 19.98 9.64 51 368319 4396 90255681
Renal impairment neonatal 19.91 9.64 8 368362 54 90260023
Atrial thrombosis 19.85 9.64 34 368336 2211 90257866
Balance disorder 19.81 9.64 526 367844 96554 90163523
Eye injury 19.80 9.64 10 368360 11010 90249067
Acute pulmonary oedema 19.52 9.64 84 368286 9496 90250581
Diverticulum 19.39 9.64 99 368271 12014 90248063
Hypomania 19.39 9.64 6 368364 8891 90251186
Multiple-drug resistance 19.34 9.64 4 368366 7772 90252305
Neutrophil function disorder 19.33 9.64 6 368364 16 90260061
Rash maculo-papular 19.29 9.64 93 368277 40840 90219237
Blood electrolytes decreased 19.28 9.64 27 368343 1473 90258604
Tethered cord syndrome 19.22 9.64 13 368357 281 90259796
Orthostatic hypotension 19.22 9.64 257 368113 41570 90218507
Incorrect dose administered 19.21 9.64 438 367932 78492 90181585
Vasoplegia syndrome 19.06 9.64 38 368332 2776 90257301
Suicidal ideation 18.99 9.64 200 368170 73655 90186422
CD30 expression 18.98 9.64 8 368362 62 90260015
Congenital nail disorder 18.95 9.64 9 368361 95 90259982
Degenerative aortic valve disease 18.89 9.64 11 368359 181 90259896
Chloropsia 18.87 9.64 8 368362 63 90260014
Heart valve incompetence 18.83 9.64 42 368328 3320 90256757
Unintentional medical device removal 18.81 9.64 3 368367 7027 90253050
Computerised tomogram head abnormal 18.63 9.64 5 368365 6 90260071
Cerebral ischaemia 18.62 9.64 68 368302 7128 90252949
Neutropenic sepsis 18.60 9.64 28 368342 18102 90241975
Ecchymosis 18.54 9.64 99 368271 12224 90247853
Hypocapnia 18.47 9.64 16 368354 505 90259572
Arrhythmia neonatal 18.44 9.64 8 368362 67 90260010
Haematocrit decreased 18.39 9.64 255 368115 41577 90218500
Joint dislocation 18.38 9.64 106 368264 44476 90215601
Progressive multifocal leukoencephalopathy 18.27 9.64 22 368348 15633 90244444
Central nervous system lupus 18.21 9.64 25 368345 1338 90258739
Peripheral sensorimotor neuropathy 18.12 9.64 31 368339 2014 90258063
Foetal exposure during pregnancy 18.10 9.64 260 368110 42715 90217362
Diabetic neuropathy 18.06 9.64 50 368320 4524 90255553
Adrenalectomy 18.04 9.64 4 368366 0 90260077
Peripheral artery stenosis 17.97 9.64 17 368353 603 90259474
Dysstasia 17.95 9.64 168 368202 24884 90235193
Multiple drug therapy 17.94 9.64 66 368304 6943 90253134
Pathergy reaction 17.85 9.64 8 368362 73 90260004
Pulmonary thrombosis 17.85 9.64 83 368287 9699 90250378
Pruritus 17.79 9.64 1928 366442 539597 89720480
Depressed level of consciousness 17.74 9.64 404 367966 72380 90187697
Drug therapeutic incompatibility 17.71 9.64 7 368363 45 90260032
Skin tightness 17.66 9.64 49 368321 4439 90255638
Peripartum cardiomyopathy 17.59 9.64 11 368359 207 90259870
Dyspnoea at rest 17.58 9.64 51 368319 4740 90255337
Somnolence 17.53 9.64 1028 367342 208056 90052021
Withdrawal hypertension 17.47 9.64 10 368360 159 90259918
Malignant hypertension 17.44 9.64 23 368347 1184 90258893
Subclavian vein thrombosis 17.35 9.64 31 368339 2085 90257992
Therapy partial responder 17.34 9.64 40 368330 22003 90238074
Ejection fraction decreased 17.31 9.64 173 368197 26080 90233997
Intracranial aneurysm 17.29 9.64 48 368322 4350 90255727
Headache 17.28 9.64 3166 365204 859580 89400497
Vascular stent thrombosis 17.27 9.64 22 368348 1094 90258983
Dystonia 17.23 9.64 26 368344 16793 90243284
Left ventricular failure 17.07 9.64 63 368307 6637 90253440
Labile blood pressure 16.98 9.64 29 368341 1881 90258196
Chest discomfort 16.97 9.64 706 367664 137659 90122418
Blood catecholamines increased 16.97 9.64 7 368363 51 90260026
Carcinoid tumour 16.96 9.64 14 368356 413 90259664
Chronic gastritis 16.91 9.64 43 368327 3698 90256379
Foot fracture 16.90 9.64 174 368196 26432 90233645
Facial bones fracture 16.86 9.64 43 368327 3704 90256373
Tooth erosion 16.84 9.64 15 368355 492 90259585
Stent malfunction 16.80 9.64 8 368362 85 90259992
Cerebrovascular disorder 16.79 9.64 36 368334 2770 90257307
Atrial conduction time prolongation 16.76 9.64 6 368364 28 90260049
Jaundice cholestatic 16.76 9.64 10 368360 10033 90250044
Retroperitoneal haemorrhage 16.71 9.64 38 368332 3042 90257035
Congenital diaphragmatic hernia 16.71 9.64 11 368359 227 90259850
Hypertensive nephropathy 16.69 9.64 17 368353 661 90259416
Traumatic haemorrhage 16.61 9.64 16 368354 581 90259496
Cerebral artery occlusion 16.59 9.64 21 368349 1038 90259039
Vertigo 16.55 9.64 386 367984 69425 90190652
Catheterisation cardiac 16.52 9.64 51 368319 4905 90255172
Mechanical urticaria 16.45 9.64 16 368354 588 90259489
Cardiac fibrillation 16.45 9.64 16 368354 588 90259489
Gastrointestinal toxicity 16.41 9.64 9 368361 9458 90250619
Medication overuse headache 16.36 9.64 25 368345 1476 90258601
Device dislocation 16.35 9.64 69 368301 31413 90228664
Allergic reaction to excipient 16.28 9.64 18 368352 770 90259307
Hyperthermia 16.27 9.64 11 368359 10324 90249753
Dilatation atrial 16.21 9.64 29 368341 1952 90258125
Blood glucose abnormal 16.20 9.64 79 368291 9413 90250664
Oesophagitis chemical 16.20 9.64 5 368365 13 90260064
Haemorrhagic transformation stroke 16.13 9.64 23 368347 1276 90258801
Peptic ulcer 16.13 9.64 54 368316 5421 90254656
COVID-19 16.09 9.64 840 367530 168003 90092074
Mitral valve calcification 16.05 9.64 22 368348 1176 90258901
Pulmonary arterial hypertension 16.04 9.64 170 368200 26017 90234060
Heart valve replacement 15.98 9.64 18 368352 786 90259291
Hypogammaglobulinaemia 15.96 9.64 12 368358 10662 90249415
Neutrophil count decreased 15.93 9.64 200 368170 71332 90188745
Dizziness postural 15.92 9.64 76 368294 8977 90251100
Drug use disorder 15.87 9.64 7 368363 8336 90251741
Memory impairment 15.81 9.64 648 367722 196596 90063481
Metastases to fallopian tube 15.80 9.64 7 368363 62 90260015
Postural orthostatic tachycardia syndrome 15.78 9.64 31 368339 2241 90257836
Small fibre neuropathy 15.76 9.64 17 368353 707 90259370
Electrocardiogram QRS complex shortened 15.74 9.64 15 368355 537 90259540
Tachycardia induced cardiomyopathy 15.73 9.64 8 368362 99 90259978
General symptom 15.69 9.64 22 368348 14646 90245431
Embolism arterial 15.64 9.64 21 368349 1100 90258977
Wrist fracture 15.63 9.64 113 368257 15511 90244566
Anticoagulation drug level below therapeutic 15.62 9.64 17 368353 714 90259363
Aortic valve disease 15.50 9.64 23 368347 1323 90258754
Diastolic dysfunction 15.49 9.64 65 368305 7268 90252809
QRS axis abnormal 15.49 9.64 22 368348 1216 90258861
Accelerated hypertension 15.44 9.64 14 368356 470 90259607
Alpha hydroxybutyrate dehydrogenase increased 15.44 9.64 5 368365 16 90260061
Arterial stenosis 15.43 9.64 17 368353 724 90259353
Enterocolitis 15.43 9.64 12 368358 10478 90249599
Weight decreased 15.42 9.64 1767 366603 378143 89881934
Parkinsonism 15.40 9.64 104 368266 13961 90246116
Peripheral coldness 15.38 9.64 103 368267 13789 90246288
Ventricular hypertrophy 15.35 9.64 39 368331 3352 90256725
Coronary artery thrombosis 15.34 9.64 21 368349 1121 90258956
Fracture 15.30 9.64 147 368223 21929 90238148
Splenic injury 15.29 9.64 10 368360 204 90259873
Glycosylated haemoglobin increased 15.25 9.64 112 368258 15450 90244627
Pollakiuria 15.25 9.64 203 368167 32802 90227275
Splenic haemorrhage 15.21 9.64 10 368360 206 90259871
Nasal oedema 15.16 9.64 4 368366 6580 90253497
Brain contusion 15.16 9.64 16 368354 649 90259428
Dyschromatopsia 15.14 9.64 17 368353 740 90259337
Pathogen resistance 15.13 9.64 7 368363 8108 90251969
Upper limb fracture 15.11 9.64 144 368226 21434 90238643
Venoocclusive liver disease 15.08 9.64 3 368367 5990 90254087
Conjunctival cyst 15.07 9.64 7 368363 70 90260007
Cardiac discomfort 15.06 9.64 21 368349 1141 90258936
Herbal interaction 15.04 9.64 9 368361 156 90259921
Blood parathyroid hormone increased 15.01 9.64 39 368331 3398 90256679
Blood pressure systolic decreased 15.01 9.64 76 368294 9194 90250883
Thrombin time prolonged 14.99 9.64 8 368362 110 90259967
Mitral valve sclerosis 14.99 9.64 9 368361 157 90259920
Myxoedema 14.99 9.64 9 368361 157 90259920
Electrocardiogram ST segment depression 14.96 9.64 38 368332 3265 90256812
Gastroenteritis clostridial 14.96 9.64 16 368354 659 90259418
Cerebral ventricular rupture 14.96 9.64 10 368360 212 90259865
Respiratory alkalosis 14.93 9.64 39 368331 3409 90256668
Leukocytosis 14.90 9.64 192 368178 30798 90229279
Sodium retention 14.89 9.64 9 368361 159 90259918
Mesenteric haemorrhage 14.87 9.64 6 368364 41 90260036
Delirium 14.87 9.64 317 368053 104042 90156035
Feeling cold 14.87 9.64 174 368196 27291 90232786
Pneumocystis jirovecii pneumonia 14.86 9.64 42 368328 21574 90238503
Aneurysm 14.86 9.64 40 368330 3560 90256517
Disorientation 14.83 9.64 257 368113 43857 90216220
Fracture blisters 14.81 9.64 7 368363 73 90260004
Optic ischaemic neuropathy 14.79 9.64 26 368344 1726 90258351
Diabetes mellitus inadequate control 14.77 9.64 128 368242 18556 90241521
Congenital megaureter 14.74 9.64 8 368362 114 90259963
Visual field defect 14.73 9.64 63 368307 7103 90252974
Hyperparathyroidism 14.71 9.64 38 368332 3299 90256778
Spinal cord haematoma 14.60 9.64 10 368360 221 90259856
Body temperature increased 14.58 9.64 114 368256 44596 90215481
Cerebellar haemorrhage 14.57 9.64 25 368345 1628 90258449
Linear IgA disease 14.56 9.64 30 368340 2244 90257833
Drug clearance decreased 14.54 9.64 27 368343 1871 90258206
Carotid artery disease 14.52 9.64 25 368345 1632 90258445
Retching 14.50 9.64 130 368240 19029 90241048
Newborn persistent pulmonary hypertension 14.48 9.64 11 368359 287 90259790
Calciphylaxis 14.43 9.64 38 368332 3338 90256739
Cardiovascular symptom 14.38 9.64 8 368362 120 90259957
Regurgitation 14.38 9.64 29 368341 2137 90257940
Renal vasculitis 14.37 9.64 13 368357 435 90259642
Capillary disorder 14.33 9.64 8 368362 121 90259956
Cardiac failure chronic 14.31 9.64 53 368317 5593 90254484
Urinary tract infection bacterial 14.29 9.64 57 368313 6228 90253849
Oral pain 14.27 9.64 199 368171 32484 90227593
Tongue blistering 14.22 9.64 27 368343 1903 90258174
Normal newborn 14.21 9.64 48 368322 23314 90236763
Kidney duplex 14.21 9.64 8 368362 123 90259954
Blood iron decreased 14.18 9.64 123 368247 17836 90242241
Hiatus hernia strangulated 14.03 9.64 11 368359 301 90259776
Arthritis 13.99 9.64 547 367823 166768 90093309
Defaecation disorder 13.89 9.64 18 368352 911 90259166
Gastrointestinal dysplasia 13.86 9.64 6 368364 50 90260027
Arrhythmia supraventricular 13.86 9.64 20 368350 1122 90258955
Electrocardiogram QT interval abnormal 13.81 9.64 10 368360 242 90259835
Neonatal anuria 13.76 9.64 6 368364 51 90260026
Non-cardiac chest pain 13.75 9.64 59 368311 6662 90253415
Device adhesion issue 13.73 9.64 5 368365 6686 90253391
Incisional hernia 13.72 9.64 26 368344 1830 90258247
Cyanopsia 13.68 9.64 4 368366 8 90260069
Polyhydramnios 13.67 9.64 31 368339 2477 90257600
Ischaemia 13.67 9.64 50 368320 5245 90254832
Puncture site haemorrhage 13.67 9.64 12 368358 386 90259691
Angiocardiogram 13.66 9.64 6 368364 52 90260025
Pneumothorax spontaneous 13.65 9.64 18 368352 927 90259150
Humerus fracture 13.64 9.64 77 368293 9708 90250369
Intentional dose omission 13.63 9.64 121 368249 17662 90242415
Intentional self-injury 13.62 9.64 67 368303 29267 90230810
High density lipoprotein decreased 13.61 9.64 32 368338 2619 90257458
Hypothalamo-pituitary disorder 13.60 9.64 29 368341 2223 90257854
Petechiae 13.59 9.64 110 368260 15631 90244446
Product dispensing error 13.59 9.64 91 368279 12182 90247895
Lymphocyte count decreased 13.57 9.64 85 368285 34965 90225112
Bundle branch block bilateral 13.53 9.64 5 368365 26 90260051
Diabetic enteropathy 13.53 9.64 3 368367 0 90260077
Pacemaker generated rhythm 13.53 9.64 3 368367 0 90260077
Foetal renal impairment 13.53 9.64 3 368367 0 90260077
Arterial catheterisation 13.53 9.64 3 368367 0 90260077
Aortic aneurysm repair 13.53 9.64 3 368367 0 90260077
Accidental overdose 13.52 9.64 175 368195 28098 90231979
Mononeuropathy multiplex 13.51 9.64 12 368358 392 90259685
Clostridium difficile colitis 13.50 9.64 167 368203 26539 90233538
Mouth ulceration 13.47 9.64 101 368269 39873 90220204
Radiculopathy 13.44 9.64 35 368335 18470 90241607
Gastrointestinal arteriovenous malformation 13.40 9.64 14 368356 561 90259516
Unwanted awareness during anaesthesia 13.36 9.64 12 368358 398 90259679
Coronary artery restenosis 13.34 9.64 11 368359 324 90259753
Anticoagulation drug level above therapeutic 13.33 9.64 27 368343 1995 90258082
Urogenital haemorrhage 13.29 9.64 10 368360 257 90259820
Therapeutic product effect increased 13.27 9.64 21 368349 1278 90258799
Generalised oedema 13.27 9.64 127 368243 18926 90241151
Activated partial thromboplastin time prolonged 13.27 9.64 65 368305 7760 90252317
Genital labial adhesions 13.23 9.64 5 368365 28 90260049
Postinfarction angina 13.23 9.64 5 368365 28 90260049
Hyperthyroidism 13.22 9.64 123 368247 18187 90241890
Rabbit syndrome 13.20 9.64 11 368359 329 90259748
Communication disorder 13.19 9.64 36 368334 3230 90256847
Implantable defibrillator insertion 13.18 9.64 14 368356 572 90259505
Brain stem infarction 13.17 9.64 17 368353 857 90259220
Upper respiratory tract infection 13.15 9.64 409 367961 127909 90132168
Red blood cell count decreased 13.14 9.64 263 368107 46088 90213989
Renal artery stenosis 13.10 9.64 28 368342 2149 90257928
Intentional underdose 13.09 9.64 27 368343 2022 90258055
Epinephrine increased 13.07 9.64 4 368366 10 90260067
Negative cardiac inotropic effect 13.07 9.64 4 368366 10 90260067
Central nervous system injury 13.06 9.64 8 368362 145 90259932
Rash erythematous 13.06 9.64 186 368184 64918 90195159
Hypertransaminasaemia 13.04 9.64 28 368342 15797 90244280
Gastroenteritis bacterial 13.04 9.64 12 368358 411 90259666
Non-high-density lipoprotein cholesterol increased 13.02 9.64 9 368361 202 90259875
Nasal polyps 13.01 9.64 15 368355 10865 90249212
Tendonitis 12.94 9.64 44 368326 21328 90238749
Gastric cyst 12.89 9.64 7 368363 100 90259977
Overweight 12.85 9.64 53 368317 5881 90254196
Blood cholesterol abnormal 12.83 9.64 33 368337 2857 90257220
Duodenitis 12.82 9.64 43 368327 4320 90255757
Peripheral artery thrombosis 12.82 9.64 28 368342 2182 90257895
Left-to-right cardiac shunt 12.81 9.64 10 368360 272 90259805
Post-anoxic myoclonus 12.80 9.64 5 368365 31 90260046
Antithyroid arthritis syndrome 12.80 9.64 4 368366 11 90260066
Femoral pulse decreased 12.80 9.64 4 368366 11 90260066
Bone density decreased 12.77 9.64 117 368253 17228 90242849
Lung infiltration 12.77 9.64 106 368264 15176 90244901
Embolism venous 12.77 9.64 38 368332 3582 90256495
Congenital uterine anomaly 12.73 9.64 8 368362 152 90259925
Blood creatine phosphokinase MB increased 12.70 9.64 20 368350 1212 90258865
Stupor 12.70 9.64 50 368320 5432 90254645
Diet noncompliance 12.63 9.64 12 368358 428 90259649
Abdominal wall haematoma 12.60 9.64 36 368334 3316 90256761
Metastases to ovary 12.58 9.64 13 368357 514 90259563
Peritonitis 12.58 9.64 129 368241 19576 90240501
Metastases to bone 12.58 9.64 57 368313 25448 90234629
Neonatal asphyxia 12.57 9.64 11 368359 352 90259725
Cyanosis neonatal 12.56 9.64 12 368358 431 90259646
Intracardiac thrombus 12.56 9.64 29 368341 2345 90257732
Aspiration pleural cavity 12.54 9.64 17 368353 899 90259178
Gastric disorder 12.52 9.64 198 368172 33186 90226891
Myopathy 12.52 9.64 96 368274 13422 90246655
Prerenal failure 12.50 9.64 27 368343 2088 90257989
Puncture site haematoma 12.50 9.64 6 368364 65 90260012
Pyuria 12.46 9.64 27 368343 2092 90257985
Coarctation of the aorta 12.45 9.64 14 368356 610 90259467
Arterial stent insertion 12.42 9.64 5 368365 34 90260043
Blood pressure immeasurable 12.41 9.64 22 368348 1470 90258607
Gastrointestinal stromal tumour 12.41 9.64 21 368349 1352 90258725
Adrenal insufficiency 12.41 9.64 71 368299 29850 90230227
Skin hyperpigmentation 12.40 9.64 58 368312 6793 90253284
Graft versus host disease 12.38 9.64 9 368361 8135 90251942
Premature delivery 12.38 9.64 224 368146 38538 90221539
Tracheo-oesophageal fistula 12.34 9.64 15 368355 711 90259366
Chemical burn of oral cavity 12.34 9.64 6 368364 67 90260010
Rectal prolapse 12.34 9.64 28 368342 2239 90257838
Restlessness 12.33 9.64 209 368161 35511 90224566
Pulmonary congestion 12.30 9.64 127 368243 19306 90240771
Microcephaly 12.29 9.64 21 368349 1363 90258714
Skin abrasion 12.26 9.64 83 368287 11152 90248925
Pulmonary hypoplasia 12.21 9.64 11 368359 366 90259711
Chronic left ventricular failure 12.20 9.64 14 368356 624 90259453
Low density lipoprotein increased 12.20 9.64 65 368305 8020 90252057
Amenorrhoea 12.13 9.64 18 368352 11704 90248373
Cholestasis 12.09 9.64 92 368278 36207 90223870
Total cholesterol/HDL ratio decreased 12.08 9.64 4 368366 14 90260063
Fluid replacement 12.08 9.64 14 368356 631 90259446
Drug-disease interaction 12.06 9.64 17 368353 933 90259144
Hypochromic anaemia 12.02 9.64 27 368343 2144 90257933
Hypoperfusion 11.98 9.64 24 368346 1760 90258317
Bradykinesia 11.95 9.64 57 368313 6731 90253346
Disease risk factor 11.94 9.64 9 368361 232 90259845
Thalamus haemorrhage 11.90 9.64 15 368355 738 90259339
Oliguria 11.90 9.64 79 368291 10545 90249532
Intraocular lens implant 11.87 9.64 11 368359 380 90259697
Migraine without aura 11.87 9.64 15 368355 740 90259337
Brugada syndrome 11.86 9.64 12 368358 463 90259614
Adjustment disorder 11.85 9.64 13 368357 9629 90250448
Alkalosis hypochloraemic 11.84 9.64 9 368361 235 90259842
Haemorrhoids 11.83 9.64 163 368207 26539 90233538
Pregnancy with contraceptive device 11.81 9.64 3 368367 5063 90255014
Glomerulonephritis 11.80 9.64 29 368341 2441 90257636
Peripheral ischaemia 11.79 9.64 50 368320 5617 90254460
Cholelithiasis 11.74 9.64 288 368082 52218 90207859
Brain natriuretic peptide increased 11.74 9.64 52 368318 5953 90254124
Neck pain 11.73 9.64 363 368007 113600 90146477
Anticoagulation drug level increased 11.73 9.64 10 368360 309 90259768
Renal cancer metastatic 11.67 9.64 10 368360 311 90259766
Congenital aqueductal stenosis 11.67 9.64 4 368366 16 90260061
Microtia 11.63 9.64 11 368359 390 90259687
Bradycardia neonatal 11.63 9.64 18 368352 1075 90259002
Sinus arrhythmia 11.59 9.64 21 368349 1428 90258649
Biliary obstruction 11.58 9.64 35 368335 3327 90256750
Hypertrophic cardiomyopathy 11.55 9.64 27 368343 2201 90257876
Vascular stent stenosis 11.54 9.64 14 368356 662 90259415
Jaw disorder 11.53 9.64 49 368321 5510 90254567
Eye discharge 11.52 9.64 65 368305 8193 90251884
Resting tremor 11.50 9.64 16 368354 867 90259210
Lipid metabolism disorder 11.48 9.64 8 368362 182 90259895
Pacemaker syndrome 11.46 9.64 3 368367 3 90260074
Product use complaint 11.45 9.64 36 368334 3497 90256580
Systemic infection 11.42 9.64 44 368326 4731 90255346
Cerebellar hypoplasia 11.42 9.64 7 368363 127 90259950
Respiratory tract congestion 11.39 9.64 65 368305 27345 90232732
Blood creatinine abnormal 11.37 9.64 40 368330 4117 90255960
Haemorrhagic erosive gastritis 11.36 9.64 12 368358 487 90259590
Tooth extraction 11.36 9.64 83 368287 11430 90248647
Hepatocellular injury 11.33 9.64 70 368300 28888 90231189
Bronchopulmonary aspergillosis 11.31 9.64 18 368352 11380 90248697
Iliac artery occlusion 11.30 9.64 9 368361 252 90259825
Drug titration error 11.29 9.64 19 368351 1218 90258859
Oral candidiasis 11.28 9.64 91 368279 35364 90224713
Intensive care unit acquired weakness 11.25 9.64 17 368353 994 90259083
Therapy cessation 11.22 9.64 209 368161 36152 90223925
Central nervous system haemorrhage 11.18 9.64 9 368361 256 90259821
Troponin I increased 11.17 9.64 29 368341 2526 90257551
Gastrointestinal mucosal exfoliation 11.14 9.64 7 368363 133 90259944
Pain of skin 11.10 9.64 107 368263 15975 90244102
Sensory loss 11.09 9.64 37 368333 18038 90242039
Anaphylactic shock 11.08 9.64 79 368291 31538 90228539
Heart sounds abnormal 11.07 9.64 14 368356 691 90259386
Renal aplasia 11.07 9.64 11 368359 415 90259662
Paternal exposure during pregnancy 11.05 9.64 10 368360 335 90259742
Cranial nerve disorder 11.04 9.64 14 368356 693 90259384
Pulmonary tuberculosis 11.01 9.64 3 368367 4831 90255246
Blood albumin abnormal 10.96 9.64 18 368352 1131 90258946
Abdominal pain lower 10.95 9.64 178 368192 29999 90230078
Ovarian cyst 10.94 9.64 35 368335 17283 90242794
Giant cell arteritis 10.88 9.64 32 368338 2997 90257080
Skin necrosis 10.87 9.64 34 368336 16907 90243170
Malignant neoplasm progression 10.86 9.64 341 368029 106529 90153548
Hypochromasia 10.83 9.64 10 368360 344 90259733
Narcotic bowel syndrome 10.82 9.64 7 368363 140 90259937
Ballismus 10.82 9.64 7 368363 140 90259937
Neurologic neglect syndrome 10.79 9.64 12 368358 8835 90251242
Congenital clavicular agenesis 10.79 9.64 6 368364 90 90259987
Lymphopenia 10.77 9.64 52 368318 22829 90237248
Adenocarcinoma 10.76 9.64 33 368337 3163 90256914
Electrocardiogram ST-T segment abnormal 10.75 9.64 11 368359 430 90259647
Decreased appetite 10.75 9.64 1715 366655 374825 89885252
Blood triglycerides increased 10.73 9.64 94 368276 13667 90246410
Paradoxical drug reaction 10.71 9.64 5 368365 5761 90254316
Blood creatine phosphokinase increased 10.65 9.64 196 368174 33827 90226250
Left atrial dilatation 10.63 9.64 24 368346 1912 90258165
Pancreatic cyst 10.62 9.64 26 368344 2184 90257893
Urinary incontinence 10.60 9.64 213 368157 37353 90222724
Underdose 10.59 9.64 155 368215 53862 90206215
Epstein-Barr virus infection 10.59 9.64 16 368354 10328 90249749
Thrombosis in device 10.58 9.64 32 368338 3043 90257034
Blood pressure systolic abnormal 10.55 9.64 42 368328 19436 90240641
Albumin urine present 10.53 9.64 9 368361 279 90259798
Polyglandular autoimmune syndrome type II 10.51 9.64 5 368365 53 90260024
Cardiac flutter 10.50 9.64 42 368328 4596 90255481
Renal cell carcinoma stage IV 10.49 9.64 4 368366 23 90260054
Foetal heart rate decreased 10.49 9.64 8 368362 210 90259867
Coagulation time prolonged 10.48 9.64 22 368348 1668 90258409
Abnormal dreams 10.45 9.64 80 368290 11177 90248900
Respiratory depression 10.44 9.64 103 368267 15472 90244605
Pancreatic carcinoma 10.44 9.64 64 368306 8313 90251764
Urate nephropathy 10.40 9.64 7 368363 150 90259927
Prescription drug used without a prescription 10.39 9.64 33 368337 3222 90256855
Cerebral atrophy 10.37 9.64 48 368322 5598 90254479
Serum serotonin increased 10.36 9.64 8 368362 214 90259863
Lacrimal gland enlargement 10.35 9.64 4 368366 24 90260053
Pancreatic carcinoma metastatic 10.33 9.64 27 368343 2361 90257716
Atrial tachycardia 10.33 9.64 50 368320 5940 90254137
Enterococcus test positive 10.30 9.64 19 368351 1310 90258767
Hypercapnia 10.29 9.64 54 368316 6623 90253454
Ventricular dysfunction 10.29 9.64 36 368334 3695 90256382
Amaurosis fugax 10.28 9.64 13 368357 642 90259435
Chronic cutaneous lupus erythematosus 10.26 9.64 15 368355 851 90259226
Intra-aortic balloon placement 10.26 9.64 3 368367 6 90260071
Umbilical hernia, obstructive 10.26 9.64 3 368367 6 90260071
Bronchoscopy abnormal 10.26 9.64 3 368367 6 90260071
Thyroglossal cyst 10.26 9.64 3 368367 6 90260071
Malignant atrophic papulosis 10.26 9.64 3 368367 6 90260071
Jugular vein distension 10.26 9.64 17 368353 1076 90259001
Hair texture abnormal 10.26 9.64 42 368328 4645 90255432
Cerebellar infarction 10.25 9.64 26 368344 2232 90257845
Convulsive threshold lowered 10.25 9.64 11 368359 455 90259622
Cardiac valve vegetation 10.25 9.64 10 368360 369 90259708
Aphasia 10.23 9.64 237 368133 42575 90217502
Carbon dioxide abnormal 10.23 9.64 8 368362 218 90259859
Ventricular assist device insertion 10.22 9.64 4 368366 25 90260052
Ligament pain 10.20 9.64 8 368362 219 90259858
Electrocardiogram ST-T change 10.17 9.64 16 368354 969 90259108
Agranulocytosis 10.17 9.64 92 368278 34910 90225167
Dermatitis exfoliative generalised 10.16 9.64 5 368365 5588 90254489
Renal dysplasia 10.14 9.64 10 368360 374 90259703
Secondary hypertension 10.13 9.64 9 368361 294 90259783
Acne 10.10 9.64 71 368299 28436 90231641
Immobile 10.04 9.64 52 368318 6346 90253731
Pneumonia 10.03 9.64 2824 365546 635235 89624842
Micturition disorder 9.99 9.64 31 368339 2989 90257088
Metabolic syndrome 9.97 9.64 23 368347 1859 90258218
Apical granuloma 9.97 9.64 5 368365 60 90260017
Lumbar vertebral fracture 9.95 9.64 58 368312 7400 90252677
Dysarthria 9.94 9.64 291 368079 54191 90205886
Intervertebral discitis 9.94 9.64 3 368367 4517 90255560
Pleuritic pain 9.94 9.64 17 368353 10444 90249633
Tarsal tunnel syndrome 9.94 9.64 12 368358 565 90259512
Sinoatrial block 9.93 9.64 16 368354 989 90259088
Fear of injection 9.90 9.64 12 368358 8503 90251574
Spinal fusion surgery 9.90 9.64 22 368348 12261 90247816
Vascular dementia 9.89 9.64 12 368358 568 90259509
Cardiac resynchronisation therapy 9.83 9.64 4 368366 28 90260049
Aortic surgery 9.83 9.64 4 368366 28 90260049
Fluid imbalance 9.79 9.64 10 368360 390 90259687
Bundle branch block right 9.75 9.64 46 368324 5407 90254670
General physical health deterioration 9.75 9.64 1614 366756 353501 89906576
Environmental exposure 9.73 9.64 6 368364 110 90259967
Influenza 9.71 9.64 674 367696 138590 90121487
Aortic valve disease mixed 9.68 9.64 7 368363 169 90259908
Vaginal oedema 9.66 9.64 3 368367 8 90260069
Bone marrow failure 9.66 9.64 84 368286 32137 90227940

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1481.44 11.25 2970 306574 121039 42190752
Cardiac failure congestive 834.64 11.25 1889 307655 83713 42228078
Bradycardia 704.19 11.25 1767 307777 83717 42228074
Atrial fibrillation 679.94 11.25 2394 307150 137199 42174592
Coronary artery disease 670.69 11.25 1312 308232 52408 42259383
BRASH syndrome 599.73 11.25 284 309260 1541 42310250
Off label use 546.74 11.25 2587 306957 635748 41676043
Hypotension 435.46 11.25 3280 306264 254351 42057440
Acute myocardial infarction 434.07 11.25 1159 308385 57006 42254785
Dizziness 396.42 11.25 3129 306415 246125 42065666
Syncope 386.15 11.25 1587 307957 97819 42213972
Coronary artery bypass 363.05 11.25 292 309252 4518 42307273
Drug ineffective 340.01 11.25 2940 306604 627257 41684534
Drug abuse 329.27 11.25 175 309369 104596 42207195
Completed suicide 326.93 11.25 1478 308066 94987 42216804
Febrile neutropenia 267.71 11.25 595 308949 185108 42126683
Dyspnoea 244.09 11.25 4538 305006 438083 41873708
Suspected suicide 227.11 11.25 252 309292 5947 42305844
Product prescribing error 221.23 11.25 546 308998 25566 42286225
Neutropenia 214.96 11.25 736 308808 198695 42113096
Coronary arterial stent insertion 211.74 11.25 198 309346 3787 42308004
Cerebrovascular accident 193.23 11.25 1288 308256 95872 42215919
Angina unstable 190.49 11.25 317 309227 11131 42300660
Angina pectoris 165.60 11.25 571 308973 32325 42279466
Pyrexia 165.09 11.25 1950 307594 392092 41919699
Fall 161.36 11.25 2494 307050 232026 42079765
Chest pain 154.46 11.25 1621 307923 137909 42173882
Drug reaction with eosinophilia and systemic symptoms 149.64 11.25 59 309485 42016 42269775
Cardiac disorder 147.52 11.25 725 308819 48207 42263584
Myelosuppression 146.78 11.25 55 309489 40406 42271385
Hepatic cytolysis 141.54 11.25 15 309529 26829 42284962
Asthenia 139.94 11.25 2837 306707 277956 42033835
Product use in unapproved indication 138.82 11.25 779 308765 183677 42128114
Therapeutic product effect incomplete 119.61 11.25 207 309337 70732 42241059
Atrial flutter 116.90 11.25 332 309212 16919 42294872
Arrhythmia 114.21 11.25 587 308957 39730 42272061
Mucosal inflammation 112.90 11.25 115 309429 49259 42262532
Sinus bradycardia 112.74 11.25 298 309246 14555 42297236
Treatment failure 111.85 11.25 176 309368 62448 42249343
Fatigue 111.45 11.25 4035 305509 431606 41880185
International normalised ratio increased 109.59 11.25 661 308883 47507 42264284
Interstitial lung disease 104.42 11.25 262 309282 78200 42233591
Vascular graft 103.93 11.25 88 309456 1468 42310323
Coronary artery occlusion 102.88 11.25 239 309305 10758 42301033
Ventricular tachycardia 102.68 11.25 463 309081 29697 42282094
Hepatic function abnormal 99.83 11.25 137 309407 51430 42260361
Hypertensive emergency 96.31 11.25 78 309466 1219 42310572
Eosinophilia 94.70 11.25 61 309483 32838 42278953
Lower respiratory tract infection 93.05 11.25 97 309447 41109 42270682
Cardiac arrest 92.80 11.25 1207 308337 108113 42203678
Rhabdomyolysis 92.24 11.25 919 308625 77100 42234691
Ejection fraction decreased 90.68 11.25 359 309185 21728 42290063
Obstructive airways disorder 87.57 11.25 35 309509 24724 42287067
Gastrointestinal haemorrhage 86.76 11.25 1088 308456 96638 42215153
General physical health deterioration 86.73 11.25 1562 307982 149684 42162107
Dehydration 86.61 11.25 1479 308065 140288 42171503
Septic shock 85.20 11.25 359 309185 91313 42220478
Product monitoring error 79.71 11.25 127 309417 4296 42307495
Drug resistance 78.03 11.25 80 309464 34168 42277623
Neutrophil count decreased 77.38 11.25 221 309323 63194 42248597
Rash maculo-papular 76.31 11.25 96 309448 37407 42274384
Acute coronary syndrome 73.90 11.25 257 309287 14608 42297183
Nodal arrhythmia 70.88 11.25 56 309488 843 42310948
Cytomegalovirus infection 70.77 11.25 78 309466 32228 42279563
Coronary artery stenosis 69.59 11.25 199 309345 10180 42301611
Bronchopulmonary aspergillosis 69.48 11.25 27 309517 19402 42292389
Drug dependence 68.54 11.25 66 309478 29028 42282763
Therapy partial responder 68.08 11.25 30 309514 19991 42291800
Asthma 67.65 11.25 229 309315 62085 42249706
Disease progression 67.40 11.25 692 308852 142964 42168827
Intentional product use issue 66.93 11.25 281 309263 71552 42240239
Cytokine release syndrome 66.23 11.25 140 309404 44387 42267404
Appendicitis 65.33 11.25 34 309510 20579 42291212
Myocardial ischaemia 65.26 11.25 279 309265 17483 42294308
Acute lung injury 64.15 11.25 68 309476 1521 42310270
Atrioventricular block complete 64.07 11.25 205 309339 11159 42300632
Bone marrow failure 62.97 11.25 89 309455 33004 42278787
Haemophagocytic lymphohistiocytosis 62.44 11.25 27 309517 18195 42293596
Thrombocytopenia 62.32 11.25 989 308555 189290 42122501
Lymphopenia 62.03 11.25 40 309504 21523 42290268
Condition aggravated 61.31 11.25 1434 308110 259320 42052471
Bronchiectasis 61.27 11.25 27 309517 17992 42293799
Haematotoxicity 60.94 11.25 5 309539 10980 42300811
Hyperkalaemia 60.34 11.25 869 308675 79589 42232202
Pathogen resistance 58.84 11.25 7 309537 11443 42300348
Infusion related reaction 58.43 11.25 235 309309 60571 42251220
Respiratory symptom 56.56 11.25 7 309537 11099 42300692
Injury 55.77 11.25 314 309230 22002 42289789
Immune reconstitution inflammatory syndrome 55.22 11.25 5 309539 10138 42301653
Agranulocytosis 54.67 11.25 86 309458 30526 42281265
Multiple organ dysfunction syndrome 54.34 11.25 447 309097 96588 42215203
Incorrect route of product administration 53.99 11.25 58 309486 24247 42287544
Sedation 53.12 11.25 87 309457 30388 42281403
Cytomegalovirus infection reactivation 52.40 11.25 9 309535 11169 42300622
Orthostatic hypotension 52.35 11.25 391 309153 30179 42281612
Mitral valve incompetence 52.32 11.25 248 309296 16241 42295550
Dyspnoea exertional 51.85 11.25 575 308969 49573 42262218
Aggression 50.91 11.25 158 309386 44005 42267786
Synovitis 50.35 11.25 25 309519 15542 42296249
Pneumocystis jirovecii pneumonia 49.64 11.25 66 309478 25115 42286676
Suicidal ideation 49.58 11.25 181 309363 47980 42263811
Device interaction 49.45 11.25 38 309506 548 42311243
Oedema peripheral 49.34 11.25 1316 308228 134760 42177031
Atrioventricular block 49.33 11.25 168 309376 9447 42302344
Heart rate increased 48.99 11.25 597 308947 52658 42259133
Aspergillus infection 48.90 11.25 27 309517 15810 42295981
Cardiac failure chronic 48.60 11.25 167 309377 9434 42302357
Haematoma 48.31 11.25 359 309185 27664 42284127
Renal failure 47.90 11.25 1375 308169 142351 42169440
Hypertensive crisis 47.77 11.25 173 309371 10033 42301758
Migraine 47.70 11.25 69 309475 25345 42286446
Toxic skin eruption 47.60 11.25 20 309524 13710 42298081
Haematochezia 47.38 11.25 640 308904 57796 42253995
Exercise tolerance decreased 47.35 11.25 123 309421 5943 42305848
Anaphylactic shock 47.01 11.25 61 309483 23456 42288335
Pancytopenia 46.28 11.25 590 308954 117153 42194638
Ascites 46.09 11.25 233 309311 56445 42255346
Product use issue 46.01 11.25 347 309197 76404 42235387
Anhedonia 46.00 11.25 141 309403 7499 42304292
Cholestasis 45.92 11.25 107 309437 32772 42279019
Liver disorder 45.58 11.25 142 309402 39502 42272289
Renal injury 45.19 11.25 193 309351 12087 42299704
Blood glucose increased 44.99 11.25 769 308775 72930 42238861
Blood creatinine increased 44.93 11.25 1081 308463 108922 42202869
Drug intolerance 44.79 11.25 371 309173 80053 42231738
Sinus node dysfunction 44.37 11.25 104 309440 4708 42307083
Toxic epidermal necrolysis 44.21 11.25 79 309465 26671 42285120
Drug hypersensitivity 43.27 11.25 487 309057 98902 42212889
Haemorrhage intracranial 43.03 11.25 242 309302 16950 42294841
Blood loss anaemia 43.02 11.25 162 309382 9574 42302217
Extrapyramidal disorder 42.56 11.25 34 309510 16378 42295413
Unevaluable event 42.50 11.25 408 309136 33880 42277911
Acute graft versus host disease 42.27 11.25 5 309539 8210 42303581
Bacterial infection 42.01 11.25 87 309457 27792 42283999
Malignant neoplasm progression 41.92 11.25 545 308999 107855 42203936
C-reactive protein increased 41.68 11.25 280 309264 63280 42248511
Multiple-drug resistance 41.56 11.25 3 309541 7319 42304472
Sopor 41.51 11.25 22 309522 13180 42298611
Ventricular extrasystoles 41.48 11.25 200 309344 13190 42298601
Venoocclusive liver disease 40.86 11.25 12 309532 10290 42301501
Haemoglobin decreased 40.79 11.25 1255 308289 131216 42180575
Hyperphosphataemia 40.40 11.25 22 309522 12982 42298809
Blood pressure increased 40.22 11.25 997 308547 100931 42210860
Hepatocellular injury 39.97 11.25 69 309475 23609 42288182
Substance abuse 39.96 11.25 8 309536 8897 42302894
Rhinitis 39.09 11.25 19 309525 11958 42299833
Seizure 38.64 11.25 629 308915 119932 42191859
Somnolence 38.63 11.25 757 308787 140348 42171443
Atrial thrombosis 38.43 11.25 66 309478 2378 42309413
Cerebral haemorrhage 38.11 11.25 442 309102 38524 42273267
Anaphylactic reaction 38.09 11.25 170 309374 42573 42269218
Hyperthermia 38.02 11.25 22 309522 12552 42299239
Intentional product misuse 37.99 11.25 278 309266 61622 42250169
Colitis 37.55 11.25 192 309352 46380 42265411
Infective pulmonary exacerbation of cystic fibrosis 37.30 11.25 6 309538 7812 42303979
Hyponatraemia 37.10 11.25 516 309028 100946 42210845
Fear 36.32 11.25 167 309377 10798 42300993
Sinus arrest 36.26 11.25 60 309484 2096 42309695
Loss of personal independence in daily activities 35.99 11.25 213 309331 49603 42262188
Palpitations 35.85 11.25 543 309001 50254 42261537
Hypogammaglobulinaemia 35.67 11.25 21 309523 11870 42299921
Suicide attempt 35.52 11.25 193 309351 45907 42265884
Myasthenia gravis 35.30 11.25 39 309505 16098 42295693
Progressive multifocal leukoencephalopathy 35.14 11.25 20 309524 11516 42300275
Heart rate decreased 35.11 11.25 413 309131 36119 42275672
Systemic infection 35.09 11.25 100 309444 5105 42306686
Altered state of consciousness 34.92 11.25 103 309441 29156 42282635
Labelled drug-drug interaction medication error 34.89 11.25 213 309331 15369 42296422
Nephrogenic systemic fibrosis 34.86 11.25 78 309466 3423 42308368
Eczema 34.49 11.25 129 309415 33957 42277834
Pulmonary vasculitis 34.35 11.25 3 309541 6263 42305528
Aplastic anaemia 34.24 11.25 24 309520 12360 42299431
Cardiac operation 34.22 11.25 80 309464 3615 42308176
Mitral valve disease 33.83 11.25 48 309496 1462 42310329
Rheumatoid arthritis 33.63 11.25 176 309368 42264 42269527
Cardiac failure 33.33 11.25 1014 308530 105842 42205949
Neuroleptic malignant syndrome 33.21 11.25 66 309478 21406 42290385
Therapeutic drug monitoring analysis not performed 33.02 11.25 30 309514 552 42311239
C-reactive protein abnormal 32.90 11.25 13 309531 9248 42302543
Irritability 32.87 11.25 100 309444 28028 42283763
Presyncope 32.66 11.25 276 309268 22111 42289680
Agitation 32.57 11.25 304 309240 64010 42247781
Pulmonary fibrosis 32.52 11.25 93 309451 26588 42285203
Blood pressure abnormal 32.18 11.25 151 309393 9847 42301944
Disseminated intravascular coagulation 32.03 11.25 84 309460 24710 42287081
Lung disorder 31.98 11.25 210 309334 47713 42264078
Blood urine present 31.95 11.25 169 309375 11564 42300227
Supraventricular tachycardia 31.94 11.25 176 309368 12232 42299559
Peripheral vascular disorder 31.89 11.25 98 309446 5219 42306572
Respiratory depression 31.83 11.25 55 309489 18813 42292978
Coma 31.68 11.25 243 309301 53311 42258480
Ventricular arrhythmia 31.59 11.25 109 309435 6170 42305621
Status epilepticus 31.56 11.25 40 309504 15538 42296253
Mental status changes 31.21 11.25 454 309090 41661 42270130
Atrioventricular block first degree 31.21 11.25 111 309433 6380 42305411
Myxoedema coma 31.18 11.25 21 309523 243 42311548
Wound 31.06 11.25 222 309322 16895 42294896
Hyperthyroidism 30.83 11.25 194 309350 14147 42297644
Heart rate irregular 30.79 11.25 211 309333 15839 42295952
Acute graft versus host disease in skin 30.66 11.25 8 309536 7416 42304375
Plasma cell myeloma 30.33 11.25 500 309044 47078 42264713
Abdominal pain lower 30.12 11.25 170 309374 11922 42299869
Forced expiratory volume decreased 30.06 11.25 9 309535 7621 42304170
Nodule 30.03 11.25 28 309516 12506 42299285
COVID-19 29.94 11.25 628 308916 115320 42196471
Nodal rhythm 29.93 11.25 47 309497 1570 42310221
Pacemaker generated rhythm 29.65 11.25 13 309531 57 42311734
Conjunctivitis allergic 29.44 11.25 4 309540 5907 42305884
Epstein-Barr virus infection 29.38 11.25 17 309527 9701 42302090
Prostate cancer 29.10 11.25 197 309347 44446 42267345
Acute generalised exanthematous pustulosis 29.03 11.25 13 309531 8582 42303209
Hyperbilirubinaemia 28.94 11.25 67 309477 20568 42291223
Blood phosphorus increased 28.82 11.25 29 309515 12496 42299295
Neuralgia 28.68 11.25 93 309451 25554 42286237
Hypophosphataemia 28.58 11.25 69 309475 20876 42290915
Stomatitis 28.09 11.25 232 309312 50097 42261694
Impaired work ability 27.81 11.25 28 309516 12063 42299728
Upper gastrointestinal haemorrhage 27.57 11.25 339 309205 29960 42281831
Tricuspid valve incompetence 27.52 11.25 156 309388 10957 42300834
Abnormal behaviour 27.49 11.25 99 309445 26352 42285439
Pericardial haemorrhage 27.48 11.25 72 309472 3497 42308294
Shone complex 27.23 11.25 13 309531 72 42311719
Coronary angioplasty 26.95 11.25 23 309521 388 42311403
Respiratory distress 26.54 11.25 186 309358 41634 42270157
Pneumonia aspiration 26.53 11.25 234 309310 49844 42261947
Obsessive-compulsive disorder 26.48 11.25 8 309536 6735 42305056
Blood pressure inadequately controlled 26.46 11.25 62 309482 2806 42308985
Graft versus host disease 26.38 11.25 33 309511 12892 42298899
Mite allergy 26.14 11.25 3 309541 5043 42306748
Tumour lysis syndrome 26.00 11.25 79 309465 22152 42289639
Atrioventricular block second degree 25.89 11.25 78 309466 4109 42307682
Circulatory collapse 25.80 11.25 274 309270 23362 42288429
Extrasystoles 25.64 11.25 78 309466 4131 42307660
Type IIa hyperlipidaemia 25.48 11.25 20 309524 298 42311493
Emotional distress 25.41 11.25 202 309342 15891 42295900
Blood pressure decreased 25.26 11.25 578 308966 57754 42254037
Epilepsy 25.22 11.25 101 309443 26070 42285721
Impaired quality of life 25.15 11.25 40 309504 14137 42297654
Urticaria 25.14 11.25 382 309162 73654 42238137
No adverse event 25.03 11.25 173 309371 38848 42272943
Neoplasm progression 24.85 11.25 117 309427 28883 42282908
Post transplant lymphoproliferative disorder 24.79 11.25 18 309526 9102 42302689
Low cardiac output syndrome 24.67 11.25 27 309517 627 42311164
Chronic kidney disease 24.64 11.25 481 309063 46760 42265031
Glomerular filtration rate decreased 24.61 11.25 203 309341 16148 42295643
Muscle necrosis 24.58 11.25 34 309510 1011 42310780
Systemic lupus erythematosus 24.57 11.25 19 309525 9305 42302486
Ejection fraction abnormal 24.47 11.25 38 309506 1257 42310534
Blood glucose decreased 24.41 11.25 182 309362 14037 42297754
Stent placement 24.36 11.25 90 309454 5270 42306521
Bundle branch block right 24.33 11.25 120 309424 7986 42303805
Transient ischaemic attack 24.33 11.25 362 309182 33377 42278414
Leukopenia 24.25 11.25 389 309155 74357 42237434
Chest discomfort 24.12 11.25 619 308925 62997 42248794
Tachyarrhythmia 24.08 11.25 73 309471 3859 42307932
Iron deficiency 23.90 11.25 27 309517 11034 42300757
Miosis 23.79 11.25 38 309506 13408 42298383
Intercepted product preparation error 23.69 11.25 12 309532 7377 42304414
Blood potassium increased 23.68 11.25 222 309322 18314 42293477
Product residue present 23.62 11.25 59 309485 2782 42309009
Chronotropic incompetence 23.61 11.25 9 309535 25 42311766
Vascular stent thrombosis 23.55 11.25 64 309480 3178 42308613
Torsade de pointes 23.54 11.25 124 309420 8470 42303321
Hypoperfusion 23.50 11.25 39 309505 1366 42310425
Contusion 23.44 11.25 432 309112 41553 42270238
Pulmonary alveolar haemorrhage 23.38 11.25 45 309499 14771 42297020
Cardiogenic shock 23.25 11.25 376 309168 35264 42276527
Pulmonary embolism 23.22 11.25 676 308868 118936 42192855
Cardiac valve disease 23.21 11.25 66 309478 3365 42308426
Headache 23.03 11.25 1464 308080 237905 42073886
Carcinoma in situ of skin 22.96 11.25 12 309532 83 42311708
Intracardiac thrombus 22.90 11.25 53 309491 2379 42309412
Coagulopathy 22.85 11.25 254 309290 21908 42289883
Drug interaction 22.81 11.25 2243 307301 264756 42047035
Sepsis 22.80 11.25 1199 308345 198135 42113656
Diffuse large B-cell lymphoma 22.79 11.25 21 309523 9433 42302358
Diffuse large B-cell lymphoma recurrent 22.76 11.25 4 309540 4882 42306909
Anticoagulant therapy 22.75 11.25 3 309541 4532 42307259
Poisoning deliberate 22.71 11.25 24 309520 10110 42301681
Hypertriglyceridaemia 22.67 11.25 24 309520 10102 42301689
Psychomotor hyperactivity 22.34 11.25 28 309516 10930 42300861
Graft versus host disease in gastrointestinal tract 22.30 11.25 5 309539 5138 42306653
Non-cardiac chest pain 22.25 11.25 78 309466 4451 42307340
Lymphoma 22.16 11.25 44 309500 14277 42297514
Increased tendency to bruise 22.11 11.25 76 309468 4294 42307497
Cytopenia 22.06 11.25 60 309484 17437 42294354
Akathisia 22.05 11.25 26 309518 10425 42301366
Hypovolaemia 22.04 11.25 151 309393 11334 42300457
Erythema multiforme 21.94 11.25 24 309520 9953 42301838
Cystitis haemorrhagic 21.91 11.25 13 309531 7316 42304475
Full blood count decreased 21.82 11.25 237 309307 20323 42291468
Catatonia 21.77 11.25 9 309535 6230 42305561
High density lipoprotein decreased 21.69 11.25 70 309474 3827 42307964
Hypoalbuminaemia 21.64 11.25 51 309493 15559 42296232
Mouth ulceration 21.46 11.25 48 309496 14915 42296876
Pancreatitis acute 21.43 11.25 149 309395 33415 42278376
Ischaemic cardiomyopathy 21.35 11.25 99 309445 6423 42305368
Drug dose omission by device 21.34 11.25 8 309536 5878 42305913
Chronic left ventricular failure 21.33 11.25 27 309517 735 42311056
Therapeutic product effect decreased 21.15 11.25 182 309362 38968 42272823
Leukoencephalopathy 21.11 11.25 5 309539 4949 42306842
Basal ganglia haemorrhage 21.11 11.25 32 309512 1036 42310755
Drug eruption 21.03 11.25 91 309453 22984 42288807
Graft versus host disease in skin 20.80 11.25 6 309538 5206 42306585
Musculoskeletal pain 20.74 11.25 349 309195 32991 42278800
Neuropathy peripheral 20.69 11.25 572 308972 101281 42210510
Uveitis 20.66 11.25 22 309522 9236 42302555
Cytomegalovirus viraemia 20.65 11.25 27 309517 10350 42301441
Blood uric acid increased 20.60 11.25 52 309492 15495 42296296
Fluid retention 20.41 11.25 333 309211 31286 42280505
Frequent bowel movements 20.39 11.25 83 309461 21324 42290467
Tuberculosis 20.39 11.25 26 309518 10073 42301718
Wheezing 20.23 11.25 278 309266 54503 42257288
Rash 20.20 11.25 1734 307810 275220 42036571
Immune-mediated enterocolitis 20.11 11.25 8 309536 5669 42306122
Neuritis 20.10 11.25 10 309534 6210 42305581
Mitral valve prolapse 19.99 11.25 25 309519 672 42311119
Anastomotic infection 19.98 11.25 12 309532 112 42311679
Hepatitis B 19.92 11.25 12 309532 6699 42305092
Troponin increased 19.89 11.25 219 309325 18843 42292948
Infection 19.88 11.25 641 308903 111427 42200364
Postural orthostatic tachycardia syndrome 19.78 11.25 13 309531 144 42311647
Pseudomonas infection 19.77 11.25 55 309489 15868 42295923
Melaena 19.70 11.25 393 309151 38353 42273438
Chromaturia 19.68 11.25 190 309354 15799 42295992
Central nervous system lesion 19.55 11.25 17 309527 7853 42303938
Stress 19.48 11.25 216 309328 43996 42267795
Malaise 19.47 11.25 1303 308241 210853 42100938
Neurotoxicity 19.35 11.25 97 309447 23554 42288237
Thrombotic microangiopathy 19.16 11.25 50 309494 14732 42297059
Low density lipoprotein abnormal 19.15 11.25 19 309525 392 42311399
Heart rate abnormal 19.15 11.25 47 309497 2192 42309599
Pulmonary tuberculosis 19.09 11.25 8 309536 5493 42306298
Macrophages increased 19.05 11.25 13 309531 154 42311637
Left atrial enlargement 19.04 11.25 30 309514 1005 42310786
Rhinovirus infection 19.03 11.25 12 309532 6536 42305255
Dizziness postural 19.03 11.25 109 309435 7686 42304105
Vasculitis 19.01 11.25 69 309475 18325 42293466
Psychomotor skills impaired 18.99 11.25 7 309537 5197 42306594
Cytomegalovirus chorioretinitis 18.98 11.25 5 309539 4606 42307185
Occult blood positive 18.95 11.25 71 309473 4186 42307605
Fracture 18.93 11.25 112 309432 7991 42303800
Colitis ulcerative 18.86 11.25 112 309432 26063 42285728
Hepatocellular carcinoma 18.82 11.25 19 309525 8175 42303616
Hepatitis B reactivation 18.78 11.25 5 309539 4573 42307218
Therapeutic response decreased 18.71 11.25 175 309369 36837 42274954
Venoocclusive disease 18.69 11.25 3 309541 3912 42307879
Cardiac pacemaker insertion 18.68 11.25 59 309485 3189 42308602
Inspiratory capacity abnormal 18.65 11.25 11 309533 99 42311692
Essential hypertension 18.60 11.25 65 309479 3703 42308088
Alanine aminotransferase increased 18.60 11.25 494 309050 87912 42223879
Enzyme inhibition 18.58 11.25 10 309534 74 42311717
Aspartate aminotransferase increased 18.45 11.25 423 309121 76740 42235051
Haematuria 18.41 11.25 550 308994 57249 42254542
Generalised tonic-clonic seizure 18.41 11.25 114 309430 26265 42285526
Death 18.41 11.25 3781 305763 467404 41844387
Diabetic foetopathy 18.33 11.25 14 309530 200 42311591
Internal haemorrhage 18.28 11.25 83 309461 5338 42306453
Device leakage 18.26 11.25 29 309515 10256 42301535
Hypoglycaemia neonatal 18.25 11.25 45 309499 2105 42309686
Cholelithiasis 18.22 11.25 254 309290 23092 42288699
Aorta hypoplasia 18.19 11.25 11 309533 104 42311687
Echolalia 18.16 11.25 18 309526 371 42311420
Bradycardia neonatal 18.12 11.25 34 309510 1314 42310477
Diverticulum 18.11 11.25 105 309439 7436 42304355
Systemic candida 18.04 11.25 8 309536 5311 42306480
Nightmare 18.03 11.25 107 309437 24905 42286886
Nocturia 18.03 11.25 150 309394 11962 42299829
Herpes simplex 18.02 11.25 15 309529 7080 42304711
Psychotic disorder 18.00 11.25 131 309413 29077 42282714
Joint swelling 17.97 11.25 367 309177 67655 42244136
Lung opacity 17.95 11.25 10 309534 5827 42305964
Tongue discomfort 17.93 11.25 24 309520 691 42311100
Mitral valve hypoplasia 17.91 11.25 8 309536 37 42311754
Drug withdrawal syndrome 17.85 11.25 88 309456 21461 42290330
Nodular rash 17.68 11.25 11 309533 110 42311681
Exposure via ingestion 17.57 11.25 44 309500 2078 42309713
Parosmia 17.48 11.25 18 309526 7673 42304118
Balance disorder 17.30 11.25 461 309083 47184 42264607
Nocardiosis 17.29 11.25 8 309536 5182 42306609
Ventricular hypokinesia 17.29 11.25 97 309447 6787 42305004
Exposure during pregnancy 17.26 11.25 22 309522 8526 42303265
Autoimmune myocarditis 17.24 11.25 15 309529 260 42311531
Catheterisation cardiac 17.23 11.25 52 309492 2742 42309049
Large for dates baby 17.17 11.25 27 309517 903 42310888
Supravalvular aortic stenosis 17.10 11.25 8 309536 42 42311749
Cardioversion 17.03 11.25 28 309516 973 42310818
Pulmonary oedema 16.99 11.25 507 309037 52765 42259026
Neurological symptom 16.97 11.25 29 309515 9962 42301829
Priapism 16.96 11.25 13 309531 6394 42305397
Urinary tract obstruction 16.93 11.25 66 309478 3965 42307826
Immune thrombocytopenia 16.90 11.25 35 309509 11181 42300610
Gait disturbance 16.86 11.25 872 308672 97128 42214663
Orthostatic intolerance 16.81 11.25 26 309518 857 42310934
Ulcer 16.78 11.25 62 309482 16379 42295412
Polyomavirus-associated nephropathy 16.73 11.25 10 309534 5605 42306186
Vomiting 16.64 11.25 1846 307698 287877 42023914
Electrocardiogram QRS complex prolonged 16.63 11.25 85 309459 5738 42306053
Hepatitis 16.55 11.25 123 309421 27177 42284614
Total lung capacity decreased 16.46 11.25 3 309541 3567 42308224
Colorectal cancer 16.43 11.25 8 309536 5030 42306761
Drug ineffective for unapproved indication 16.42 11.25 236 309308 45927 42265864
Sinusitis 16.40 11.25 243 309301 47049 42264742
Face oedema 16.39 11.25 48 309496 13618 42298173
Musculoskeletal stiffness 16.37 11.25 308 309236 57457 42254334
Cardiovascular insufficiency 16.33 11.25 39 309505 1787 42310004
Oesophageal obstruction 16.33 11.25 21 309523 581 42311210
Peripheral arterial occlusive disease 16.29 11.25 95 309449 6743 42305048
Drug withdrawal syndrome neonatal 16.28 11.25 6 309538 4455 42307336
Kidney rupture 16.27 11.25 13 309531 199 42311592
Product solubility abnormal 16.27 11.25 21 309523 583 42311208
Oral candidiasis 16.27 11.25 52 309492 14353 42297438
Intestinal atony 16.24 11.25 8 309536 48 42311743
Loss of control of legs 16.16 11.25 25 309519 824 42310967
Orthopnoea 16.12 11.25 80 309464 5337 42306454
Encephalitis 16.09 11.25 26 309518 9132 42302659
Type 2 diabetes mellitus 16.09 11.25 205 309339 18266 42293525
Gastrointestinal disorder 16.08 11.25 240 309304 46413 42265378
Coronary artery restenosis 15.97 11.25 26 309518 896 42310895
Anal fistula 15.95 11.25 13 309531 6200 42305591
Cornea verticillata 15.82 11.25 10 309534 103 42311688
Product quality issue 15.81 11.25 199 309345 17683 42294108
Left ventricle outflow tract obstruction 15.79 11.25 12 309532 170 42311621
Haemorrhagic transformation stroke 15.75 11.25 38 309506 1753 42310038
Parathyroid hormone-related protein abnormal 15.66 11.25 6 309538 17 42311774
Arterial occlusive disease 15.63 11.25 69 309475 4384 42307407
Sickle cell anaemia with crisis 15.59 11.25 8 309536 4882 42306909
Nephropathy toxic 15.59 11.25 66 309478 16772 42295019
Tubulointerstitial nephritis 15.59 11.25 150 309394 31398 42280393
Haemodilution 15.57 11.25 7 309537 33 42311758
Electrocardiogram PR prolongation 15.56 11.25 27 309517 981 42310810
Mitral valve sclerosis 15.54 11.25 13 309531 213 42311578
Dermatitis acneiform 15.54 11.25 20 309524 7719 42304072
Upper motor neurone lesion 15.50 11.25 12 309532 175 42311616
Congenital heart valve disorder 15.47 11.25 8 309536 54 42311737
Flank pain 15.45 11.25 101 309443 7462 42304329
Bundle branch block left 15.44 11.25 90 309454 6386 42305405
Urinary tract infection 15.41 11.25 875 308669 98409 42213382
Posterior reversible encephalopathy syndrome 15.40 11.25 45 309499 12776 42299015
Psoriatic arthropathy 15.37 11.25 112 309432 24855 42286936
Post procedural haemorrhage 15.32 11.25 118 309426 9194 42302597
Cardiac flutter 15.30 11.25 42 309502 2098 42309693
Dystonia 15.28 11.25 45 309499 12745 42299046
Hypopnoea 15.19 11.25 21 309523 7861 42303930
Small for dates baby 15.15 11.25 77 309467 5186 42306605
Gastrointestinal toxicity 15.13 11.25 5 309539 3974 42307817
Hypervolaemia 15.09 11.25 244 309300 22881 42288910
Neutropenic sepsis 15.08 11.25 62 309482 15884 42295907
Fungal infection 14.95 11.25 83 309461 19639 42292152
Heart valve incompetence 14.94 11.25 35 309509 1584 42310207
Diarrhoea 14.91 11.25 3666 305878 457183 41854608
Inferior vena cava syndrome 14.89 11.25 8 309536 59 42311732
Dysmorphism 14.84 11.25 3 309541 3313 42308478
Osteonecrosis 14.80 11.25 62 309482 15803 42295988
Unresponsive to stimuli 14.80 11.25 315 309229 31088 42280703
Full blood count abnormal 14.78 11.25 142 309402 29734 42282057
International normalised ratio decreased 14.67 11.25 69 309475 4503 42307288
Patent ductus arteriosus 14.67 11.25 57 309487 3419 42308372
Spinal epidural haemorrhage 14.63 11.25 7 309537 39 42311752
Cold sweat 14.62 11.25 136 309408 11194 42300597
Neonatal respiratory failure 14.60 11.25 16 309528 372 42311419
Cardiomyopathy 14.59 11.25 208 309336 19002 42292789
Organising pneumonia 14.58 11.25 20 309524 7512 42304279
Electrolyte imbalance 14.56 11.25 189 309355 16912 42294879
Biopsy lymph gland 14.56 11.25 8 309536 62 42311729
Serotonin syndrome 14.48 11.25 119 309425 25726 42286065
BK virus infection 14.46 11.25 26 309518 8758 42303033
Neonatal epileptic seizure 14.45 11.25 8 309536 63 42311728
Intentional self-injury 14.44 11.25 59 309485 15143 42296648
Cough 14.43 11.25 1491 308053 176612 42135179
Persecutory delusion 14.42 11.25 4 309540 3560 42308231
Stevens-Johnson syndrome 14.38 11.25 98 309446 22080 42289711
Pallor 14.35 11.25 292 309252 28594 42283197
Bone erosion 14.35 11.25 7 309537 4396 42307395
Aortic valve incompetence 14.34 11.25 89 309455 6459 42305332
Ageusia 14.33 11.25 138 309406 11467 42300324
Precancerous skin lesion 14.32 11.25 20 309524 600 42311191
Pneumonia cytomegaloviral 14.32 11.25 6 309538 4120 42307671
Portal fibrosis 14.31 11.25 15 309529 331 42311460
Hyperpyrexia 14.27 11.25 4 309540 3536 42308255
Antiacetylcholine receptor antibody positive 14.22 11.25 9 309535 93 42311698
Muscular weakness 14.17 11.25 742 308802 82756 42229035
Haemorrhage 14.16 11.25 556 308988 60007 42251784
Diastolic dysfunction 14.11 11.25 93 309451 6890 42304901
Prohormone brain natriuretic peptide increased 14.06 11.25 9 309535 95 42311696
Blood pressure orthostatic 14.04 11.25 8 309536 67 42311724
Penis injury 14.01 11.25 13 309531 246 42311545
Implantable defibrillator insertion 13.99 11.25 23 309521 799 42310992
Prothrombin time prolonged 13.95 11.25 117 309427 9352 42302439
Acoustic stimulation tests abnormal 13.94 11.25 8 309536 68 42311723
Aplasia 13.91 11.25 9 309535 4834 42306957
Gastrointestinal tract mucosal pigmentation 13.86 11.25 19 309525 560 42311231
Erythema 13.86 11.25 647 308897 108146 42203645
Dyskinesia 13.73 11.25 118 309426 25272 42286519
Duodenal ulcer 13.71 11.25 143 309401 12136 42299655
Gastric cancer 13.70 11.25 18 309526 6885 42304906
Euphoric mood 13.67 11.25 16 309528 6437 42305354
Arteriosclerotic gangrene 13.65 11.25 8 309536 71 42311720
Withdrawal syndrome 13.63 11.25 58 309486 14717 42297074
Acute myeloid leukaemia 13.63 11.25 100 309444 22156 42289635
Overdose 13.61 11.25 625 308919 104639 42207152
Lower gastrointestinal haemorrhage 13.58 11.25 129 309415 10679 42301112
Varicose vein 13.58 11.25 33 309511 1529 42310262
Electrocardiogram RR interval prolonged 13.51 11.25 4 309540 3 42311788
Negative cardiac inotropic effect 13.51 11.25 4 309540 3 42311788
Gout 13.41 11.25 282 309262 27773 42284018
Acute lymphocytic leukaemia recurrent 13.41 11.25 5 309539 3686 42308105
Anal fissure 13.40 11.25 11 309533 5228 42306563
Pneumonia fungal 13.39 11.25 29 309515 9117 42302674
Pulmonary valve stenosis congenital 13.38 11.25 10 309534 138 42311653
Pulseless electrical activity 13.37 11.25 106 309438 8331 42303460
Blood lactate dehydrogenase increased 13.32 11.25 123 309421 25958 42285833
Acute graft versus host disease in intestine 13.31 11.25 6 309538 3945 42307846
Neutropenic colitis 13.26 11.25 8 309536 4462 42307329
Therapeutic response shortened 13.26 11.25 52 309492 13502 42298289
Left ventricular failure 13.22 11.25 82 309462 5949 42305842
Aphthous ulcer 13.20 11.25 14 309530 5887 42305904
Oesophageal carcinoma 13.18 11.25 32 309512 9664 42302127
Acute left ventricular failure 13.17 11.25 26 309518 1044 42310747
Radiotherapy to brain 13.10 11.25 7 309537 51 42311740
Conjunctivitis 13.07 11.25 49 309495 12890 42298901
Tachycardia induced cardiomyopathy 13.03 11.25 10 309534 144 42311647
Paranoia 12.97 11.25 55 309489 13971 42297820
Blood parathyroid hormone increased 12.97 11.25 37 309507 1890 42309901
Pulse pressure decreased 12.97 11.25 11 309533 184 42311607
Blood bicarbonate abnormal 12.95 11.25 9 309535 110 42311681
Hepatitis cholestatic 12.91 11.25 33 309511 9791 42302000
Faeces pale 12.88 11.25 33 309511 1581 42310210
Left ventricular dysfunction 12.87 11.25 134 309410 11367 42300424
Blue toe syndrome 12.85 11.25 10 309534 147 42311644
N-terminal prohormone brain natriuretic peptide abnormal 12.85 11.25 12 309532 229 42311562
Muscle rupture 12.84 11.25 43 309501 2397 42309394
Faeces discoloured 12.83 11.25 184 309360 16830 42294961
Epistaxis 12.82 11.25 601 308943 66225 42245566
Rheumatoid nodule 12.81 11.25 3 309541 2992 42308799
Retching 12.81 11.25 99 309445 7722 42304069
Blood sodium decreased 12.75 11.25 194 309350 17968 42293823
Transplant rejection 12.74 11.25 53 309491 13535 42298256
Eosinophil count decreased 12.73 11.25 5 309539 3571 42308220
Angioedema 12.67 11.25 401 309143 42076 42269715
Folliculitis 12.64 11.25 13 309531 5545 42306246
Total cholesterol/HDL ratio increased 12.63 11.25 11 309533 191 42311600
Carotid artery stenosis 12.61 11.25 75 309469 5361 42306430
Vascular access site occlusion 12.55 11.25 7 309537 56 42311735
Drug abuser 12.47 11.25 5 309539 3526 42308265
Product name confusion 12.45 11.25 8 309536 85 42311706
Arterial intramural haematoma 12.45 11.25 7 309537 57 42311734
Cytomegalovirus test positive 12.44 11.25 8 309536 4311 42307480
Lymphadenopathy 12.43 11.25 169 309375 33196 42278595
Angioplasty 12.41 11.25 25 309519 1019 42310772
Pulmonary renal syndrome 12.40 11.25 12 309532 240 42311551
Gingival pain 12.38 11.25 27 309517 8467 42303324
Hemiparesis 12.35 11.25 186 309358 17190 42294601
Bacterial parotitis 12.32 11.25 6 309538 35 42311756
Cardiovascular somatic symptom disorder 12.32 11.25 6 309538 35 42311756
Multiple injuries 12.30 11.25 36 309508 1866 42309925
Atrial septal defect 12.28 11.25 99 309445 7820 42303971
Increased viscosity of bronchial secretion 12.24 11.25 12 309532 244 42311547
Immunosuppression 12.22 11.25 27 309517 8426 42303365
Lymphocyte count decreased 12.19 11.25 136 309408 27673 42284118
Arteriosclerosis 12.19 11.25 191 309353 17798 42293993
Acquired mixed hyperlipidaemia 12.11 11.25 4 309540 6 42311785
Infantile apnoea 12.10 11.25 26 309518 1110 42310681
Maternal exposure during pregnancy 12.09 11.25 20 309524 6958 42304833
Therapy non-responder 12.06 11.25 295 309249 53064 42258727
Pseudomonal sepsis 12.06 11.25 8 309536 4241 42307550
Vascular device infection 12.06 11.25 16 309528 6094 42305697
Carcinoid tumour of the gastrointestinal tract 12.05 11.25 7 309537 61 42311730
Iliac artery stenosis 12.05 11.25 9 309535 124 42311667
Drug-disease interaction 12.01 11.25 23 309521 903 42310888
Multiple sclerosis relapse 11.96 11.25 58 309486 14206 42297585
Pneumonia bacterial 11.92 11.25 66 309478 15626 42296165
Psychiatric decompensation 11.92 11.25 8 309536 4214 42307577
Stenotrophomonas infection 11.90 11.25 6 309538 3698 42308093
Acute lymphocytic leukaemia 11.89 11.25 5 309539 3426 42308365
Hypertensive urgency 11.84 11.25 16 309528 465 42311326
Tenosynovitis 11.83 11.25 10 309534 4685 42307106
Lacunar infarction 11.81 11.25 51 309493 3209 42308582
Myofascial spasm 11.80 11.25 3 309541 0 42311791
Abdominal bruit 11.80 11.25 3 309541 0 42311791
Venous pressure jugular abnormal 11.80 11.25 3 309541 0 42311791
Urinary sediment 11.80 11.25 3 309541 0 42311791
Non-small cell lung cancer stage IIIA 11.80 11.25 3 309541 0 42311791
Temperature regulation disorder 11.74 11.25 26 309518 1133 42310658
Intracranial pressure increased 11.73 11.25 10 309534 4664 42307127
Sudden cardiac death 11.71 11.25 58 309486 3866 42307925
Sinus rhythm 11.69 11.25 15 309529 414 42311377
Mucosal haemorrhage 11.69 11.25 34 309510 1756 42310035
Prescribed underdose 11.60 11.25 120 309424 10162 42301629
Facial asymmetry 11.58 11.25 14 309530 363 42311428
Vasoplegia syndrome 11.58 11.25 44 309500 2611 42309180
Hepatojugular reflux 11.56 11.25 19 309525 660 42311131
Joint injury 11.55 11.25 61 309483 14615 42297176
Diverticulum intestinal haemorrhagic 11.54 11.25 48 309496 2971 42308820
Hip fracture 11.51 11.25 149 309395 13323 42298468
Vocal cord inflammation 11.51 11.25 7 309537 67 42311724
Percutaneous coronary intervention 11.48 11.25 12 309532 264 42311527
Apallic syndrome 11.48 11.25 13 309531 314 42311477
Hyperammonaemia 11.47 11.25 25 309519 7841 42303950
Nail pitting 11.44 11.25 15 309529 423 42311368
Subacute cutaneous lupus erythematosus 11.44 11.25 30 309514 1458 42310333
Dermatitis bullous 11.42 11.25 28 309516 8428 42303363
Palmar-plantar erythrodysaesthesia syndrome 11.42 11.25 95 309449 20487 42291304
Hospice care 11.40 11.25 103 309441 8410 42303381
Klebsiella infection 11.39 11.25 43 309501 11289 42300502
Pleural effusion 11.38 11.25 836 308708 96330 42215461
Secretion discharge 11.35 11.25 24 309520 7611 42304180
Arthralgia 11.33 11.25 1311 308233 203927 42107864
Haemolysis 11.27 11.25 34 309510 9555 42302236

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 3270.64 10.03 4424 553964 187659 109843252
Cardiac failure congestive 1970.69 10.03 3068 555320 147932 109882979
Atrial fibrillation 1785.42 10.03 3723 554665 225919 109804992
Bradycardia 1734.71 10.03 2943 555445 152574 109878337
Coronary artery disease 1543.43 10.03 1857 556531 69833 109961078
Completed suicide 1462.52 10.03 3553 554835 238828 109792083
BRASH syndrome 1339.46 10.03 554 557834 3169 110027742
Hypotension 1253.38 10.03 5600 552788 518249 109512662
Acute myocardial infarction 1107.32 10.03 1713 556675 82064 109948847
Synovitis 1063.31 10.03 85 558303 274007 109756904
Hand deformity 959.02 10.03 32 558356 218474 109812437
Systemic lupus erythematosus 945.70 10.03 94 558294 254244 109776667
Syncope 917.44 10.03 2670 555718 199866 109831045
Anti-cyclic citrullinated peptide antibody positive 899.45 10.03 3 558385 181981 109848930
Pemphigus 889.90 10.03 47 558341 214523 109816388
Duodenal ulcer perforation 817.51 10.03 16 558372 177684 109853227
Helicobacter infection 796.83 10.03 27 558361 181850 109849061
Glossodynia 782.63 10.03 99 558289 221905 109809006
Infusion related reaction 760.60 10.03 494 557894 380668 109650243
Folliculitis 737.61 10.03 24 558364 167629 109863282
Pericarditis 705.30 10.03 127 558261 218987 109811924
Lower respiratory tract infection 693.38 10.03 185 558203 242921 109787990
Product prescribing error 666.15 10.03 1041 557347 50290 109980621
Cerebrovascular accident 656.62 10.03 2212 556176 179072 109851839
Arthropathy 647.49 10.03 321 558067 287201 109743710
Rheumatoid factor positive 635.62 10.03 5 558383 131635 109899276
Muscle injury 634.69 10.03 16 558372 140791 109890120
Joint swelling 630.15 10.03 786 557602 442059 109588852
Off label use 627.13 10.03 4725 553663 1495460 108535451
Drug intolerance 621.92 10.03 681 557707 405831 109625080
Treatment failure 607.13 10.03 321 558067 276913 109753998
Suspected suicide 606.21 10.03 548 557840 14651 110016260
Coronary artery bypass 601.50 10.03 377 558011 5665 110025246
Irritable bowel syndrome 562.59 10.03 80 558308 164135 109866776
C-reactive protein abnormal 511.88 10.03 37 558351 129658 109901253
Dyspnoea 511.35 10.03 8129 550259 1098743 108932168
Fall 501.11 10.03 4948 553440 598534 109432377
Dizziness 500.05 10.03 5555 552833 692638 109338273
Drug ineffective 468.48 10.03 5171 553217 1515369 108515542
Facet joint syndrome 456.71 10.03 6 558382 96822 109934089
Cardiac disorder 454.78 10.03 1114 557274 75166 109955745
Death 440.59 10.03 5426 552962 693443 109337468
Drug interaction 419.25 10.03 4110 554278 496073 109534838
Gastrointestinal haemorrhage 419.12 10.03 1802 556586 163716 109867195
Lip dry 417.76 10.03 21 558367 100062 109930849
Therapeutic product effect decreased 410.35 10.03 377 558011 243939 109786972
Contraindicated product administered 403.05 10.03 395 557993 247872 109783039
Hypersensitivity 401.34 10.03 904 557484 403094 109627817
Psoriatic arthropathy 400.43 10.03 249 558139 196512 109834399
Swelling 398.55 10.03 727 557661 350314 109680597
Cardiac arrest 391.70 10.03 1997 556391 194756 109836155
Hepatic enzyme increased 389.44 10.03 637 557751 320255 109710656
Angina unstable 387.20 10.03 446 557942 15986 110014925
Wound 386.37 10.03 368 558020 234069 109796842
Blister 374.62 10.03 357 558031 227019 109803892
Dehydration 372.78 10.03 2553 555835 276958 109753953
Coronary arterial stent insertion 369.88 10.03 277 558111 5638 110025273
Rheumatoid arthritis 364.27 10.03 594 557794 299019 109731892
Alopecia 356.72 10.03 823 557565 363930 109666981
Sleep disorder due to general medical condition, insomnia type 355.94 10.03 54 558334 105589 109925322
Impaired healing 347.92 10.03 289 558099 196428 109834483
Maternal exposure during pregnancy 346.15 10.03 468 557920 254415 109776496
Ill-defined disorder 339.75 10.03 184 558204 156669 109874242
International normalised ratio increased 331.97 10.03 1079 557309 85693 109945218
Sinus bradycardia 330.96 10.03 560 557828 28923 110001988
Stomatitis 325.48 10.03 539 557849 269703 109761208
Angina pectoris 318.81 10.03 859 557529 61436 109969475
Inflammation 312.96 10.03 308 558080 192930 109837981
Product monitoring error 309.99 10.03 298 558090 8629 110022282
Renal failure 307.07 10.03 2078 556310 224496 109806415
Type 2 diabetes mellitus 305.31 10.03 267 558121 176965 109853946
Bursitis 303.10 10.03 138 558250 129780 109901131
Cardiogenic shock 301.86 10.03 799 557589 56539 109974372
Rhabdomyolysis 300.25 10.03 1305 557083 119096 109911815
Fibromyalgia 298.64 10.03 254 558134 170655 109860256
C-reactive protein increased 297.02 10.03 399 557989 217520 109813391
Arrhythmia 293.56 10.03 895 557493 68680 109962231
Acute kidney injury 290.73 10.03 4663 553725 630767 109400144
Drug hypersensitivity 288.54 10.03 1245 557143 452845 109578066
Ventricular tachycardia 285.04 10.03 718 557670 49291 109981620
Musculoskeletal stiffness 282.77 10.03 620 557768 279202 109751709
Discomfort 281.73 10.03 404 557984 214303 109816608
Hyperkalaemia 279.09 10.03 1391 556997 134405 109896506
Liver injury 277.22 10.03 212 558176 150201 109880710
Joint range of motion decreased 277.14 10.03 134 558254 121698 109909213
Cardiac failure 275.60 10.03 1756 556632 185870 109845041
Sinusitis 273.72 10.03 690 557698 295998 109734913
Mobility decreased 269.07 10.03 492 557896 236930 109793981
Blood cholesterol increased 264.55 10.03 326 558062 184459 109846452
Peripheral venous disease 263.64 10.03 52 558336 84065 109946846
Grip strength decreased 258.89 10.03 46 558342 80128 109950783
Product use issue 254.66 10.03 769 557619 310926 109719985
Pyrexia 248.24 10.03 3125 555263 895140 109135771
Gastrointestinal disorder 246.17 10.03 534 557854 241418 109789493
Intentional product use issue 242.53 10.03 559 557829 247347 109783564
Lung disorder 239.95 10.03 335 558053 179712 109851199
Migraine 235.19 10.03 313 558075 171339 109859572
Blepharospasm 233.81 10.03 10 558378 54841 109976070
Urticaria 225.99 10.03 837 557551 318020 109712891
Product use in unapproved indication 223.58 10.03 1333 557055 446044 109584867
Toxicity to various agents 214.11 10.03 3512 554876 477043 109553868
Nasopharyngitis 211.62 10.03 1148 557240 393213 109637698
Wheezing 211.10 10.03 626 557762 254604 109776307
Drug abuse 209.70 10.03 358 558030 177053 109853858
Haemoglobin decreased 209.49 10.03 2047 556341 246680 109784231
Wound infection 209.10 10.03 113 558275 96352 109934559
Chest pain 207.82 10.03 2854 555534 373521 109657390
Myelosuppression 206.71 10.03 109 558279 94231 109936680
Atrial flutter 206.66 10.03 409 557979 23853 110007058
Asthenia 204.96 10.03 4735 553653 684264 109346647
Labelled drug-drug interaction medication error 204.19 10.03 455 557933 28847 110002064
Abdominal discomfort 203.45 10.03 1161 557227 392697 109638214
Adjustment disorder with depressed mood 201.56 10.03 4 558384 43879 109987032
Acute coronary syndrome 197.32 10.03 390 557998 22722 110008189
Sleep disorder 196.64 10.03 445 557943 198199 109832712
Haematochezia 196.19 10.03 1123 557265 114401 109916510
Rash 196.16 10.03 2941 555447 818023 109212888
Autoimmune disorder 195.96 10.03 45 558343 65438 109965473
Onychomadesis 195.72 10.03 8 558380 45655 109985256
Blood creatinine increased 195.10 10.03 1585 556803 181304 109849607
Pregnancy 191.98 10.03 18 558370 51049 109979862
Atrioventricular block complete 191.29 10.03 355 558033 19727 110011184
Palpitations 191.00 10.03 1418 556970 157794 109873117
Hepatic cytolysis 185.76 10.03 28 558360 55025 109975886
Live birth 184.96 10.03 60 558328 69424 109961487
Dyspnoea exertional 180.28 10.03 1017 557371 103043 109927868
Hypercholesterolaemia 179.21 10.03 119 558269 90718 109940193
X-ray abnormal 177.01 10.03 3 558385 38114 109992797
Febrile neutropenia 176.09 10.03 911 557477 315856 109715055
Bone erosion 172.59 10.03 17 558371 46354 109984557
Hypertensive emergency 170.67 10.03 139 558249 3212 110027699
Infection 169.59 10.03 1101 557287 361099 109669812
Anaemia 165.08 10.03 3768 554620 543318 109487593
Vascular graft 163.78 10.03 113 558275 2012 110028899
Myocardial ischaemia 163.58 10.03 394 557994 26290 110004621
Coronary artery occlusion 163.19 10.03 289 558099 15483 110015428
Arthralgia 159.72 10.03 2873 555515 776759 109254152
Lower limb fracture 159.35 10.03 91 558297 75257 109955654
Pulmonary fibrosis 154.63 10.03 172 558216 101870 109929041
Red blood cell sedimentation rate increased 153.90 10.03 103 558285 78199 109952712
Nail disorder 152.50 10.03 51 558337 57884 109973027
Blood loss anaemia 152.48 10.03 303 558085 17722 110013189
Hypertensive crisis 151.70 10.03 362 558026 24010 110006901
Dry mouth 150.85 10.03 511 557877 199437 109831474
Atrioventricular block 150.42 10.03 290 558098 16587 110014324
Oedema peripheral 149.22 10.03 2410 555978 326250 109704661
Epilepsy 148.49 10.03 172 558216 100037 109930874
Retinitis 148.26 10.03 3 558385 32324 109998587
Pulmonary oedema 147.05 10.03 941 557447 99718 109931193
Hypoaesthesia 145.63 10.03 958 557430 313265 109717646
Anti-neutrophil cytoplasmic antibody positive vasculitis 144.72 10.03 157 558231 5260 110025651
Liver disorder 144.57 10.03 314 558074 141929 109888982
Mental status changes 143.98 10.03 762 557626 75360 109955551
Asthma 143.51 10.03 712 557676 249579 109781332
Blood pressure increased 142.81 10.03 1960 556428 256413 109774498
Mitral valve incompetence 142.68 10.03 431 557957 32898 109998013
Prescribed overdose 142.43 10.03 139 558249 87442 109943469
Coeliac disease 141.13 10.03 24 558364 43163 109987748
Night sweats 140.99 10.03 290 558098 133693 109897218
Drug reaction with eosinophilia and systemic symptoms 140.94 10.03 124 558264 81971 109948940
Haematoma 135.31 10.03 620 557768 57856 109973055
Road traffic accident 134.11 10.03 209 558179 107189 109923722
Coronary artery stenosis 133.29 10.03 245 558143 13513 110017398
Cerebral haemorrhage 133.07 10.03 665 557723 64303 109966608
Lactic acidosis 132.73 10.03 863 557525 91948 109938963
Obesity 130.94 10.03 232 558156 113119 109917792
Ejection fraction 128.70 10.03 112 558276 2843 110028068
Renal impairment 125.11 10.03 1479 556909 186966 109843945
Neutropenia 124.93 10.03 1248 557140 373372 109657539
Therapeutic product effect incomplete 124.69 10.03 643 557745 223162 109807749
Exposure during pregnancy 124.17 10.03 431 557957 166993 109863918
Sciatica 123.99 10.03 171 558217 92228 109938683
Chronic kidney disease 123.26 10.03 732 557656 75559 109955352
Presyncope 122.67 10.03 531 557857 48356 109982555
Unresponsive to stimuli 122.32 10.03 641 557747 63149 109967762
Atrioventricular block first degree 121.39 10.03 240 558148 13985 110016926
Blood pressure decreased 119.23 10.03 991 557397 114100 109916811
Sensitisation 119.19 10.03 125 558263 4026 110026885
Osteoarthritis 116.85 10.03 499 557889 182124 109848787
Pain 116.34 10.03 3806 554582 951149 109079762
General physical health deterioration 116.22 10.03 2890 555498 422405 109608506
Hip arthroplasty 114.36 10.03 70 558318 55743 109975168
Hypoglycaemia 113.04 10.03 986 557402 115118 109915793
Blood glucose increased 112.22 10.03 1092 557296 131404 109899507
Haematuria 109.18 10.03 756 557632 82249 109948662
Sinus node dysfunction 108.44 10.03 177 558211 8870 110022041
Polycystic ovaries 106.03 10.03 126 558262 4670 110026241
Ventricular extrasystoles 105.72 10.03 302 558086 22339 110008572
Colitis ulcerative 104.99 10.03 142 558246 77221 109953690
Weight increased 104.94 10.03 1489 556899 418155 109612756
Transient ischaemic attack 104.07 10.03 615 557773 63367 109967544
Gait inability 103.89 10.03 347 558041 136029 109894882
Renal injury 103.84 10.03 266 558122 18447 110012464
Nodal arrhythmia 103.73 10.03 87 558301 2097 110028814
Mucosal inflammation 102.93 10.03 206 558182 95935 109934976
Nodal rhythm 101.73 10.03 105 558283 3318 110027593
Plasma cell myeloma 101.11 10.03 603 557785 62333 109968578
Exostosis 100.81 10.03 53 558335 45903 109985008
Product label confusion 100.59 10.03 3 558385 22674 110008237
Condition aggravated 99.08 10.03 2889 555499 731947 109298964
Frequent bowel movements 98.95 10.03 129 558259 71261 109959650
Pulmonary renal syndrome 97.88 10.03 58 558330 783 110030128
Injury 97.76 10.03 511 557877 176754 109854157
Melaena 97.49 10.03 638 557750 68119 109962792
Heart rate increased 95.95 10.03 1130 557258 142704 109888207
Incorrect route of product administration 95.94 10.03 109 558279 63952 109966959
Heart rate irregular 95.15 10.03 384 558004 33890 109997021
Hepatitis 92.98 10.03 197 558191 89857 109941054
Torsade de pointes 91.84 10.03 287 558101 22313 110008598
Urinary tract infection 91.12 10.03 2224 556164 324058 109706853
Circulatory collapse 90.83 10.03 444 557944 42549 109988362
Epistaxis 90.42 10.03 1032 557356 129340 109901571
Haemorrhage intracranial 89.74 10.03 336 558052 28633 110002278
Interstitial lung disease 89.57 10.03 380 558008 138954 109891957
Gout 89.32 10.03 394 557994 36172 109994739
Therapeutic drug monitoring analysis not performed 87.77 10.03 75 558313 1856 110029055
Heart rate decreased 87.54 10.03 716 557672 82040 109948871
Upper gastrointestinal haemorrhage 87 10.03 490 557898 49606 109981305
Drug tolerance decreased 86.34 10.03 17 558371 27523 110003388
Haemorrhage 85.81 10.03 870 557518 105822 109925089
Pleural effusion 85.06 10.03 1315 557073 176394 109854517
Acute respiratory failure 83.88 10.03 659 557729 74601 109956310
Onychomycosis 83.69 10.03 45 558343 38486 109992425
Ventricular arrhythmia 83.45 10.03 168 558220 9919 110020992
Ejection fraction abnormal 83.35 10.03 95 558293 3365 110027546
Atrioventricular block second degree 82.19 10.03 148 558240 8033 110022878
Fear 81.21 10.03 280 558108 22913 110007998
Supraventricular tachycardia 80.48 10.03 289 558099 24133 110006778
Anhedonia 80.18 10.03 214 558174 15214 110015697
Taste disorder 79.96 10.03 129 558259 65258 109965653
Back injury 78.49 10.03 74 558314 47325 109983586
Lupus-like syndrome 78.37 10.03 55 558333 40737 109990174
Ischaemic stroke 77.98 10.03 413 557975 40850 109990061
Orthostatic hypotension 77.68 10.03 587 557801 65662 109965249
Hepatic function abnormal 77.45 10.03 214 558174 89081 109941830
Hiatus hernia 77.20 10.03 310 558078 27296 110003615
Fatigue 77.09 10.03 7132 551256 1208826 108822085
Drug resistance 76.97 10.03 103 558285 56271 109974640
Knee arthroplasty 76.76 10.03 131 558257 64817 109966094
Therapy non-responder 76.20 10.03 473 557915 156834 109874077
Hypovolaemia 76.18 10.03 262 558126 21412 110009499
Laryngitis 75.31 10.03 62 558326 42349 109988562
Red blood cell sedimentation rate abnormal 75.03 10.03 16 558372 24493 110006418
Coagulopathy 74.95 10.03 406 557982 40505 109990406
Tachyarrhythmia 74.91 10.03 143 558245 8118 110022793
Unevaluable event 74.13 10.03 533 557855 58694 109972217
Pallor 74.08 10.03 514 557874 55953 109974958
Cytomegalovirus infection 73.80 10.03 100 558288 54344 109976567
Metabolic acidosis 73.46 10.03 799 557589 98945 109931966
Orthostatic intolerance 73.45 10.03 71 558317 2070 110028841
Hypervolaemia 73.22 10.03 464 557924 48996 109981915
Glomerular filtration rate decreased 73.01 10.03 315 558073 28641 110002270
Pulmonary hypertension 72.65 10.03 503 557885 54717 109976194
Lower gastrointestinal haemorrhage 72.59 10.03 232 558156 18254 110012657
Diarrhoea 72.26 10.03 6684 551704 1132821 108898090
Foot deformity 72.04 10.03 83 558305 48397 109982514
Bronchiectasis 71.71 10.03 48 558340 36445 109994466
Rash maculo-papular 71.21 10.03 169 558219 74053 109956858
Tricuspid valve incompetence 70.74 10.03 273 558115 23600 110007311
Paraesthesia 70.19 10.03 978 557410 275543 109755368
Cardiac failure chronic 70.19 10.03 190 558198 13621 110017290
Renal disorder 69.46 10.03 458 557930 49021 109981890
Injection site reaction 68.95 10.03 225 558163 88845 109942066
Febrile bone marrow aplasia 68.84 10.03 5 558383 17460 110013451
Neutrophil count decreased 68.16 10.03 346 558042 120595 109910316
Ventricular hypokinesia 68.11 10.03 165 558223 11049 110019862
Eosinophilia 67.43 10.03 118 558270 57818 109973093
Headache 66.46 10.03 3711 554677 878666 109152245
Finger deformity 65.74 10.03 43 558345 33049 109997862
Haemophagocytic lymphohistiocytosis 65.47 10.03 39 558349 31520 109999391
Therapy partial responder 64.80 10.03 55 558333 37006 109993905
Rheumatoid nodule 64.75 10.03 12 558376 20284 110010627
Blood urea increased 64.46 10.03 487 557901 54470 109976441
Nephrogenic systemic fibrosis 64.00 10.03 106 558282 5377 110025534
Maternal exposure timing unspecified 63.75 10.03 14 558374 20999 110009912
Adverse reaction 63.64 10.03 35 558353 29559 110001352
Orthopnoea 63.59 10.03 159 558229 10862 110020049
Drug level increased 63.56 10.03 436 557952 47283 109983628
Sinus arrest 63.52 10.03 92 558296 4150 110026761
Peripheral arterial occlusive disease 63.42 10.03 143 558245 9137 110021774
Product administration error 63.29 10.03 362 558026 36855 109994056
Atrial thrombosis 63.25 10.03 93 558295 4253 110026658
Bundle branch block left 63.21 10.03 175 558213 12713 110018198
Blood pressure inadequately controlled 62.99 10.03 127 558261 7506 110023405
Device expulsion 62.93 10.03 39 558349 30852 110000059
Ejection fraction decreased 62.69 10.03 387 558001 40493 109990418
Malaise 62.48 10.03 2764 555624 669055 109361856
Blood potassium increased 62.29 10.03 332 558056 32917 109997994
Acute lung injury 61.92 10.03 78 558310 3073 110027838
Arterial haemorrhage 61.87 10.03 86 558302 3733 110027178
Loss of consciousness 61.84 10.03 1361 557027 194945 109835966
Drug use disorder 61.42 10.03 9 558379 18065 110012846
Cardiovascular disorder 60.81 10.03 252 558136 22508 110008403
Cardiac failure acute 60.76 10.03 262 558126 23816 110007095
Arteriosclerosis 60.59 10.03 267 558121 24500 110006411
Sopor 60.58 10.03 57 558331 36489 109994422
Hyperlipidaemia 59.86 10.03 347 558041 35501 109995410
Electrolyte imbalance 59.62 10.03 355 558033 36673 109994238
Product dose omission issue 59.47 10.03 2083 556305 319699 109711212
Hepatic cirrhosis 59.44 10.03 161 558227 67465 109963446
Female genital tract fistula 59.07 10.03 7 558381 16512 110014399
Acute generalised exanthematous pustulosis 58.91 10.03 18 558370 21646 110009265
Cardiomegaly 58.82 10.03 297 558091 28833 110002078
Tachycardia 58.54 10.03 1529 556859 225116 109805795
Ear infection 58.48 10.03 145 558243 62587 109968324
Liver function test increased 58.45 10.03 239 558149 88309 109942602
Pericardial haemorrhage 58.42 10.03 99 558289 5118 110025793
Troponin increased 58.36 10.03 301 558087 29465 110001446
Loss of employment 58.25 10.03 78 558310 3266 110027645
Essential hypertension 58.25 10.03 125 558263 7722 110023189
Cytomegalovirus infection reactivation 58.14 10.03 11 558377 18322 110012589
Myxoedema coma 58.07 10.03 39 558349 663 110030248
Hip fracture 57.88 10.03 339 558049 34812 109996099
Ischaemic cardiomyopathy 57.62 10.03 126 558262 7885 110023026
Pathogen resistance 57.35 10.03 10 558378 17662 110013249
Heart rate abnormal 56.86 10.03 118 558270 7120 110023791
Cardiomyopathy 56.30 10.03 325 558063 33200 109997711
Vaginal discharge 56.25 10.03 11 558377 17897 110013014
Bone marrow failure 56.07 10.03 131 558257 57717 109973194
Shock 55.78 10.03 462 557926 53126 109977785
Left ventricular dysfunction 55.77 10.03 251 558137 23242 110007669
Chromaturia 55.57 10.03 294 558094 29066 110001845
Hypomagnesaemia 54.80 10.03 505 557883 59865 109971046
Carpal tunnel syndrome 54.75 10.03 243 558145 22367 110008544
Cardiac pacemaker insertion 54.60 10.03 107 558281 6194 110024717
Full blood count decreased 54.44 10.03 312 558076 31787 109999124
Electrocardiogram QRS complex prolonged 54.43 10.03 167 558221 12854 110018057
Peripheral vascular disorder 54.04 10.03 128 558260 8448 110022463
Occult blood positive 53.44 10.03 117 558271 7328 110023583
Dyspepsia 53.36 10.03 662 557726 190303 109840608
Hypokalaemia 53.12 10.03 1251 557137 181197 109849714
Arteriosclerosis coronary artery 52.77 10.03 259 558129 24859 110006052
Panniculitis 52.39 10.03 8 558380 15574 110015337
Post procedural haemorrhage 52.34 10.03 185 558203 15327 110015584
Anaphylactic reaction 52.13 10.03 350 558038 113950 109916961
Obstructive airways disorder 51.90 10.03 96 558292 46053 109984858
Systemic infection 51.84 10.03 137 558251 9682 110021229
Ischaemic hepatitis 51.78 10.03 88 558300 4560 110026351
Therapeutic response decreased 51.62 10.03 281 558107 96218 109934693
Extrasystoles 50.10 10.03 122 558266 8196 110022715
Pruritus 49.95 10.03 2413 555975 579147 109451764
Electrocardiogram abnormal 49.87 10.03 207 558181 18502 110012409
Aortic valve incompetence 49.85 10.03 145 558243 10836 110020075
Respiratory failure 49.76 10.03 1432 556956 213900 109817011
Muscle spasticity 49.66 10.03 65 558323 35850 109995061
Erythema 49.55 10.03 1107 557281 290340 109740571
Vascular stent thrombosis 49.32 10.03 81 558307 4080 110026831
Multiple-drug resistance 48.87 10.03 5 558383 13230 110017681
Progressive multifocal leukoencephalopathy 48.80 10.03 33 558355 24923 110005988
Internal haemorrhage 48.65 10.03 136 558252 9935 110020976
Diverticulum intestinal 47.78 10.03 149 558239 11570 110019341
Angioedema 47.54 10.03 730 557658 97770 109933141
Pulseless electrical activity 47.52 10.03 189 558199 16568 110014343
Blood sodium decreased 47.46 10.03 344 558044 37975 109992936
Adverse drug reaction 47.26 10.03 325 558063 105234 109925677
Acute graft versus host disease 47.21 10.03 5 558383 12876 110018035
Immunodeficiency 47.13 10.03 77 558311 38761 109992150
Bronchopulmonary aspergillosis 46.72 10.03 49 558339 29814 110001097
Sleep apnoea syndrome 46.64 10.03 357 558031 40090 109990821
Body height decreased 46.53 10.03 138 558250 10425 110020486
Cardioversion 46.44 10.03 58 558330 2265 110028646
Poisoning deliberate 46.13 10.03 39 558349 26292 110004619
Seronegative arthritis 46.10 10.03 6 558382 13171 110017740
Ageusia 45.97 10.03 209 558179 19436 110011475
Infusion site reaction 45.78 10.03 16 558372 17666 110013245
Thrombosis 45.62 10.03 787 557601 107875 109923036
Ventricular fibrillation 45.62 10.03 361 558027 40952 109989959
Blood creatine increased 45.61 10.03 145 558243 11376 110019535
Hyperthyroidism 45.49 10.03 278 558110 28983 110001928
Head injury 45.38 10.03 372 558016 42645 109988266
Granuloma skin 45.14 10.03 3 558385 11280 110019631
Agranulocytosis 45.09 10.03 160 558228 61600 109969311
Medication error 44.55 10.03 764 557624 104602 109926309
Pacemaker generated rhythm 44.49 10.03 16 558372 58 110030853
Toxic skin eruption 44.35 10.03 44 558344 27471 110003440
Anaphylactic shock 44.35 10.03 124 558264 51422 109979489
Bradyarrhythmia 44.23 10.03 85 558303 4849 110026062
Blood test abnormal 44.22 10.03 271 558117 28283 110002628
Drug eruption 44.03 10.03 132 558256 53527 109977384
Cardiac valve disease 43.94 10.03 99 558289 6322 110024589
Cardiac operation 43.93 10.03 95 558293 5900 110025011
Lymphopenia 43.91 10.03 85 558303 40085 109990826
Haematotoxicity 43.81 10.03 26 558362 21056 110009855
Device interaction 43.74 10.03 34 558354 733 110030178
Acute left ventricular failure 43.70 10.03 56 558332 2245 110028666
Aspergillus infection 43.59 10.03 39 558349 25577 110005334
International normalised ratio decreased 43.57 10.03 115 558273 8121 110022790
Stent placement 43.46 10.03 106 558282 7128 110023783
Immune reconstitution inflammatory syndrome 43.20 10.03 14 558374 16212 110014699
Chronic sinusitis 42.91 10.03 38 558350 25046 110005865
Fracture 42.73 10.03 242 558146 24546 110006365
Diverticulum intestinal haemorrhagic 42.63 10.03 82 558306 4681 110026230
Exercise tolerance decreased 42.53 10.03 146 558242 11921 110018990
Blood potassium decreased 42.42 10.03 439 557949 53675 109977236
Nephrectomy 42.10 10.03 59 558329 2581 110028330
Cardio-respiratory arrest 42.01 10.03 820 557568 115016 109915895
Joint stiffness 41.01 10.03 187 558201 67056 109963855
Blood glucose decreased 40.81 10.03 272 558116 29216 110001695
Dementia 40.77 10.03 287 558101 31386 109999525
Suicidal ideation 40.69 10.03 292 558096 93645 109937266
Infective pulmonary exacerbation of cystic fibrosis 40.66 10.03 12 558376 14759 110016152
Abortion spontaneous 40.64 10.03 69 558319 34213 109996698
Dialysis 40.29 10.03 201 558187 19418 110011493
Adverse event 40.28 10.03 353 558035 108456 109922455
Cholestasis 40.20 10.03 178 558210 64340 109966571
Acute graft versus host disease in skin 39.80 10.03 4 558384 10736 110020175
Body tinea 39.42 10.03 51 558337 2064 110028847
Blood pressure abnormal 39.37 10.03 220 558168 22204 110008707
Bundle branch block right 39.27 10.03 144 558244 12147 110018764
Respiratory disorder 39.21 10.03 206 558182 71176 109959735
Hyperthermia 39.15 10.03 30 558358 21242 110009669
Product substitution issue 39.01 10.03 224 558164 22837 110008074
Venoocclusive liver disease 38.96 10.03 14 558374 15193 110015718
Hypogammaglobulinaemia 38.65 10.03 27 558361 20049 110010862
Prothrombin time prolonged 38.44 10.03 181 558207 17080 110013831
Coronary artery dissection 38.39 10.03 39 558349 1209 110029702
Sedation 38.33 10.03 201 558187 69482 109961429
Sedation complication 37.84 10.03 27 558361 19828 110011083
Muscle necrosis 37.75 10.03 46 558342 1751 110029160
Abdominal pain lower 37.51 10.03 319 558069 36964 109993947
Pneumocystis jirovecii pneumonia 37.36 10.03 102 558286 42633 109988278
Chronic obstructive pulmonary disease 37.34 10.03 766 557622 108392 109922519
Dizziness postural 36.89 10.03 159 558229 14450 110016461
Appendicitis 36.87 10.03 54 558334 28410 110002501
Musculoskeletal pain 36.83 10.03 676 557712 182347 109848564
Faeces discoloured 36.58 10.03 295 558093 33653 109997258
Non-cardiac chest pain 36.48 10.03 124 558264 10074 110020837
Hypoperfusion 36.47 10.03 61 558327 3120 110027791
Eructation 36.27 10.03 154 558234 13903 110017008
Joint destruction 35.94 10.03 6 558382 10937 110019974
Subarachnoid haemorrhage 35.84 10.03 265 558123 29437 110001474
Disability 35.68 10.03 61 558327 30162 110000749
Acidosis 35.62 10.03 215 558173 22316 110008595
Chronic left ventricular failure 35.39 10.03 38 558350 1258 110029653
Deep vein thrombosis 35.32 10.03 941 557447 138946 109891965
Erectile dysfunction 35.25 10.03 186 558202 18370 110012541
Emotional distress 35.24 10.03 364 558024 44483 109986428
Aortic stenosis 35.21 10.03 145 558243 12914 110017997
Hepatocellular injury 35.13 10.03 134 558254 50508 109980403
Hypersensitivity myocarditis 35.07 10.03 22 558366 331 110030580
Haemodynamic instability 34.67 10.03 216 558172 22672 110008239
Decorticate posture 34.45 10.03 22 558366 342 110030569
Cough 34.44 10.03 2742 555646 458899 109572012
Type IIa hyperlipidaemia 34.31 10.03 25 558363 487 110030424
Ear pain 34.29 10.03 145 558243 53081 109977830
Mouth ulceration 34.29 10.03 126 558262 48012 109982899
Body mass index abnormal 34.17 10.03 32 558356 896 110030015
Unintentional medical device removal 33.93 10.03 3 558385 8920 110021991
Hypertensive heart disease 33.87 10.03 73 558315 4523 110026388
Blood urine present 33.77 10.03 224 558164 24021 110006890
Cytokine release syndrome 33.72 10.03 212 558176 70094 109960817
Vomiting 33.69 10.03 4055 554333 906620 109124291
Nephropathy 33.57 10.03 146 558242 13321 110017590
Hyperglycaemia 33.48 10.03 610 557778 84480 109946431
Carotid artery stenosis 33.46 10.03 113 558275 9150 110021761
High density lipoprotein decreased 33.38 10.03 83 558305 5650 110025261
Pulse absent 33.35 10.03 129 558259 11163 110019748
Food allergy 33.20 10.03 31 558357 19917 110010994
Haemorrhagic transformation stroke 33.17 10.03 57 558331 2980 110027931
Nodule 33.17 10.03 72 558316 32559 109998352
Prostatomegaly 33.14 10.03 69 558319 4173 110026738
Craniofacial fracture 33.04 10.03 31 558357 870 110030041
Product residue present 33.03 10.03 66 558322 3875 110027036
Ischaemic contracture of the left ventricle 32.97 10.03 16 558372 140 110030771
Aortic valve stenosis 32.92 10.03 88 558300 6262 110024649
Diastolic dysfunction 32.87 10.03 137 558251 12267 110018644
Cardiac ablation 32.86 10.03 53 558335 2629 110028282
Post transplant lymphoproliferative disorder 32.80 10.03 19 558369 15594 110015317
Arthritis 32.78 10.03 622 557766 166964 109863947
Urinary retention 32.69 10.03 514 557874 69169 109961742
Haematocrit decreased 32.67 10.03 492 557896 65625 109965286
Fluid retention 32.65 10.03 663 557725 93644 109937267
Device capturing issue 32.65 10.03 11 558377 31 110030880
Prescribed underdose 32.58 10.03 194 558194 64980 109965931
Aortic valve sclerosis 32.56 10.03 44 558344 1859 110029052
Myocardial depression 32.40 10.03 28 558360 704 110030207
Gastrointestinal tract mucosal pigmentation 32.36 10.03 36 558352 1241 110029670
Aortic arteriosclerosis 32.34 10.03 125 558263 10813 110020098
Forced expiratory volume decreased 32.31 10.03 13 558375 13163 110017748
Electrocardiogram T wave abnormal 32.25 10.03 68 558320 4149 110026762
Haemorrhoidal haemorrhage 32.17 10.03 102 558286 7991 110022920
Low density lipoprotein abnormal 32.12 10.03 25 558363 540 110030371
Walking aid user 32.06 10.03 48 558340 25027 110005884
Myalgia 31.98 10.03 1401 556987 220980 109809931
International normalised ratio abnormal 31.85 10.03 87 558301 6270 110024641
Blue toe syndrome 31.84 10.03 27 558361 661 110030250
Respiratory symptom 31.67 10.03 18 558370 14927 110015984
Sinus tachycardia 31.65 10.03 354 558034 44139 109986772
Product solubility abnormal 31.61 10.03 34 558354 1128 110029783
Haemarthrosis 31.58 10.03 95 558293 7234 110023677
Lethargy 31.46 10.03 655 557733 92921 109937990
Oral candidiasis 31.33 10.03 118 558270 44642 109986269
Epstein-Barr virus infection 31.32 10.03 29 558359 18709 110012202
Intraventricular haemorrhage 31.30 10.03 79 558309 5428 110025483
Hyponatraemia 31.26 10.03 1371 557017 216282 109814629
Cardiac output decreased 31.16 10.03 45 558343 2024 110028887
Oedema 31.16 10.03 814 557574 209162 109821749
Sudden cardiac death 31.14 10.03 80 558308 5557 110025354
Drug tolerance 31.02 10.03 23 558365 16562 110014349
Proctitis 30.99 10.03 24 558364 16903 110014008
Coronary artery restenosis 30.89 10.03 34 558354 1158 110029753
Phaeochromocytoma 30.85 10.03 29 558359 816 110030095
Duodenal ulcer 30.72 10.03 186 558202 19328 110011583
Subdural haematoma 30.63 10.03 300 558088 36154 109994757
Hypomania 30.58 10.03 7 558381 10203 110020708
Haemodialysis 30.55 10.03 173 558215 17546 110013365
Diverticulum 30.44 10.03 157 558231 15369 110015542
Pericardial effusion 29.93 10.03 430 557958 56787 109974124
Electrocardiogram RR interval prolonged 29.89 10.03 9 558379 15 110030896
Myopathy 29.73 10.03 222 558166 24738 110006173
Idiopathic pulmonary fibrosis 29.72 10.03 73 558315 4931 110025980
Blood cholesterol decreased 29.70 10.03 51 558337 2665 110028246
Abortion induced 29.68 10.03 3 558385 8016 110022895
Lacunar infarction 29.50 10.03 84 558304 6202 110024709
Septic shock 29.49 10.03 589 557799 156939 109873972
Mitral valve disease 29.48 10.03 58 558330 3367 110027544
Lymphatic fistula 29.36 10.03 37 558351 1458 110029453
Dilatation atrial 29.33 10.03 62 558326 3790 110027121
Graft versus host disease in gastrointestinal tract 29.27 10.03 5 558383 8963 110021948
Electrocardiogram QT prolonged 29.26 10.03 739 557649 108221 109922690
Aortic aneurysm 29.13 10.03 113 558275 9791 110021120
Hypothermia 29.13 10.03 230 558158 26072 110004839
Toxic epidermal necrolysis 28.81 10.03 168 558220 56559 109974352
Glucose tolerance impaired 28.74 10.03 112 558276 9725 110021186
Hospice care 28.66 10.03 132 558256 12341 110018570
Burning sensation 28.59 10.03 500 557888 68712 109962199
Cystitis haemorrhagic 28.41 10.03 13 558375 12196 110018715
Thyrotoxic myopathy 28.36 10.03 8 558380 9 110030902
Basal ganglia haemorrhage 28.35 10.03 41 558347 1847 110029064
Rhinitis allergic 28.32 10.03 171 558217 17751 110013160
Hypertensive urgency 28.26 10.03 32 558356 1125 110029786
Paraesthesia oral 28.23 10.03 82 558306 33589 109997322
Skin induration 28.13 10.03 66 558322 4329 110026582
Spondylitis 28.11 10.03 11 558377 11327 110019584
Pulmonary congestion 28.08 10.03 259 558129 30707 110000204
Left atrial enlargement 28.07 10.03 39 558349 1692 110029219
Left ventricular failure 28.03 10.03 123 558265 11266 110019645
Mitral valve stenosis 28.02 10.03 35 558353 1367 110029544
Serositis 27.95 10.03 37 558351 1532 110029379
Chest discomfort 27.90 10.03 1108 557280 172740 109858171
Dysuria 27.77 10.03 443 557945 59788 109971123
Echocardiogram abnormal 27.66 10.03 49 558339 2625 110028286
Heart valve incompetence 27.64 10.03 62 558326 3947 110026964
Phaeochromocytoma crisis 27.62 10.03 22 558366 492 110030419
Femoral hernia incarcerated 27.52 10.03 36 558352 1473 110029438
Aphthous ulcer 27.47 10.03 40 558348 21096 110009815
Haemorrhagic stroke 27.42 10.03 140 558248 13649 110017262
Seroma 27.33 10.03 55 558333 3246 110027665
Hypoxia 27.12 10.03 851 557537 128664 109902247
Clostridium test positive 27.08 10.03 118 558270 10775 110020136
Haematemesis 26.98 10.03 434 557954 58674 109972237
Tendonitis 26.97 10.03 57 558331 26026 110004885
Anticoagulation drug level above therapeutic 26.92 10.03 67 558321 4563 110026348
Coronary angioplasty 26.87 10.03 20 558368 403 110030508
Cholelithiasis 26.85 10.03 460 557928 62962 109967949
Vasoplegia syndrome 26.82 10.03 74 558314 5365 110025546
Non-cardiogenic pulmonary oedema 26.80 10.03 41 558347 1943 110028968
Chronotropic incompetence 26.76 10.03 13 558375 114 110030797
Schizophrenia 26.74 10.03 43 558345 21783 110009128
Breast cancer stage I 26.74 10.03 3 558385 7384 110023527
Amnesia 26.65 10.03 373 558015 105035 109925876
Exposure via ingestion 26.51 10.03 69 558319 4831 110026080
Mitral valve sclerosis 26.44 10.03 19 558369 362 110030549
Localised infection 26.43 10.03 333 558055 42715 109988196
Blood parathyroid hormone increased 26.33 10.03 63 558325 4185 110026726
Hyperhidrosis 26.27 10.03 1177 557211 186121 109844790
Carotid artery thrombosis 26.22 10.03 8 558380 9630 110021281
Drug-disease interaction 26.14 10.03 40 558348 1896 110029015
Gastritis erosive 26.12 10.03 125 558263 11875 110019036
Hypoacusis 25.95 10.03 282 558106 34909 109996002
Burns second degree 25.93 10.03 4 558384 7729 110023182
Conjunctival haemorrhage 25.82 10.03 83 558305 6550 110024361
Hypophagia 25.76 10.03 391 557997 52235 109978676
Gastrointestinal toxicity 25.74 10.03 12 558376 11136 110019775
Flatulence 25.74 10.03 388 558000 51761 109979150
Implantable defibrillator insertion 25.69 10.03 31 558357 1168 110029743
Myocardial hypoxia 25.64 10.03 8 558380 16 110030895
Colitis 25.55 10.03 363 558025 101960 109928951
Blindness transient 25.47 10.03 77 558311 5879 110025032
Peripheral swelling 25.44 10.03 1727 556661 402307 109628604
Initial insomnia 25.41 10.03 112 558276 10277 110020634
Blood albumin abnormal 25.36 10.03 26 558362 815 110030096
Supraventricular extrasystoles 25.31 10.03 94 558294 7979 110022932
Dysgeusia 25.22 10.03 495 557893 69490 109961421
Embolic stroke 25.10 10.03 99 558289 8644 110022267
Personality disorder 25.07 10.03 17 558371 12820 110018091
Graft versus host disease 25.03 10.03 35 558353 18771 110012140
Degenerative aortic valve disease 24.78 10.03 15 558373 211 110030700
Memory impairment 24.78 10.03 781 557607 196163 109834748
Renal cyst 24.77 10.03 167 558221 18005 110012906
Labile hypertension 24.68 10.03 22 558366 577 110030334
Withdrawal hypertension 24.66 10.03 19 558369 404 110030507
Left ventricular hypertrophy 24.64 10.03 132 558256 13112 110017799
Mucosal haemorrhage 24.63 10.03 50 558338 2970 110027941
Dystonia 24.56 10.03 59 558329 25746 110005165
Gastric ulcer 24.41 10.03 308 558080 39519 109991392
Respiratory arrest 24.38 10.03 422 557966 57877 109973034
Drug-induced liver injury 24.29 10.03 443 557945 119624 109911287
Normal newborn 24.22 10.03 46 558342 21850 110009061
Therapy cessation 24.22 10.03 339 558049 44518 109986393
Tooth erosion 24.15 10.03 19 558369 417 110030494
Negative cardiac inotropic effect 24.15 10.03 8 558380 21 110030890
Pulmonary tuberculosis 24.13 10.03 8 558380 9131 110021780
Cerebral artery occlusion 24.09 10.03 39 558349 1941 110028970
Cold sweat 24.04 10.03 192 558196 21839 110009072
Loss of personal independence in daily activities 24.03 10.03 575 557813 149445 109881466
Fibrosis 23.97 10.03 89 558299 7553 110023358
Maternal exposure before pregnancy 23.82 10.03 4 558384 7261 110023650
Retroperitoneal haemorrhage 23.71 10.03 76 558312 5989 110024922
Feeling abnormal 23.71 10.03 1128 557260 179583 109851328
Pancreatic steatosis 23.70 10.03 37 558351 1785 110029126
Extrapyramidal disorder 23.69 10.03 71 558317 28796 110002115
Catheterisation cardiac 23.68 10.03 77 558311 6114 110024797
Gastritis 23.66 10.03 392 557996 53307 109977604
Lymphoproliferative disorder 23.61 10.03 4 558384 7214 110023697
Procedural pain 23.46 10.03 96 558292 35469 109995442
Cardioactive drug level increased 23.45 10.03 57 558331 3825 110027086
Heparin-induced thrombocytopenia 23.43 10.03 117 558271 11307 110019604
Blood parathyroid hormone decreased 23.41 10.03 19 558369 13070 110017841
Balance disorder 23.39 10.03 762 557626 115798 109915113
Electrocardiogram PR prolongation 23.38 10.03 37 558351 1806 110029105
Penis injury 23.35 10.03 12 558376 120 110030791
Carotid artery disease 23.34 10.03 41 558347 2182 110028729
Faeces pale 23.24 10.03 52 558336 3305 110027606
Hyperprolactinaemia 22.99 10.03 3 558385 6572 110024339
Neutropenic sepsis 22.88 10.03 79 558309 30667 110000244
Multiple injuries 22.84 10.03 54 558334 3560 110027351
Listless 22.83 10.03 62 558326 4453 110026458
Electrocardiogram ST segment depression 22.79 10.03 70 558318 5391 110025520
Malignant neoplasm progression 22.76 10.03 689 557699 173878 109857033
HELLP syndrome 22.72 10.03 25 558363 851 110030060
Rash erythematous 22.72 10.03 284 558104 81548 109949363
Blood pressure systolic abnormal 22.72 10.03 58 558330 24792 110006119
Confusional state 22.70 10.03 2047 556341 466633 109564278
Contusion 22.68 10.03 955 557433 232406 109798505
Gastrointestinal arteriovenous malformation 22.41 10.03 26 558362 939 110029972
Groin pain 22.38 10.03 144 558244 15284 110015627
Diabetic neuropathy 22.36 10.03 82 558306 6917 110023994
Retroperitoneal haematoma 22.33 10.03 75 558313 6056 110024855
Electrocardiogram QRS complex shortened 22.32 10.03 24 558364 796 110030115
Cardiorenal syndrome 22.28 10.03 37 558351 1881 110029030
Neck pain 22.26 10.03 463 557925 122667 109908244
Vascular resistance pulmonary decreased 22.26 10.03 10 558378 72 110030839
Retching 22.26 10.03 193 558195 22489 110008422
Anastomotic infection 22.22 10.03 12 558376 134 110030777
Graft versus host disease in skin 22.19 10.03 7 558381 8247 110022664
Coronary artery thrombosis 22.18 10.03 50 558338 3194 110027717
Peripheral coldness 22.14 10.03 165 558223 18375 110012536
Inspiratory capacity abnormal 22.12 10.03 11 558377 102 110030809
Ventricular hypertrophy 22.06 10.03 82 558306 6963 110023948
Subchondral insufficiency fracture 21.97 10.03 9 558379 50 110030861
Cervicogenic headache 21.96 10.03 14 558374 217 110030694
Product name confusion 21.90 10.03 14 558374 218 110030693
Urosepsis 21.79 10.03 244 558144 30431 110000480
Limb injury 21.78 10.03 288 558100 37348 109993563
Insomnia 21.76 10.03 1547 556841 359043 109671868
Diffuse large B-cell lymphoma 21.75 10.03 29 558359 15869 110015042
Polyarthritis 21.72 10.03 39 558349 18924 110011987
Blood pressure systolic decreased 21.72 10.03 129 558259 13312 110017599
Oesophageal obstruction 21.66 10.03 29 558359 1214 110029697
Skin tightness 21.64 10.03 70 558318 5543 110025368
Thalamus haemorrhage 21.64 10.03 37 558351 1927 110028984
Blood creatine phosphokinase increased 21.54 10.03 502 557886 72575 109958336
QRS axis abnormal 21.49 10.03 42 558346 2426 110028485
Cerebral ischaemia 21.42 10.03 119 558269 11985 110018926
Nasal polyps 21.40 10.03 21 558367 13179 110017732
Micturition disorder 21.29 10.03 62 558326 4636 110026275
Organ failure 21.28 10.03 63 558325 4754 110026157
Anuria 21.28 10.03 202 558186 24139 110006772
Peripheral artery occlusion 21.25 10.03 46 558342 2859 110028052
Substance abuse 21.18 10.03 19 558369 12444 110018467
Diverticulitis 21.16 10.03 384 558004 53138 109977773
Low cardiac output syndrome 21.13 10.03 27 558361 1079 110029832
Cytomegalovirus chorioretinitis 21.12 10.03 5 558383 7123 110023788
Accelerated hypertension 21.12 10.03 23 558365 774 110030137
Immune-mediated myositis 21.06 10.03 74 558314 6112 110024799
Thrombin time prolonged 21.02 10.03 16 558372 334 110030577
Carcinoma in situ of skin 20.99 10.03 13 558375 191 110030720
Infection susceptibility increased 20.86 10.03 59 558329 4339 110026572
Vision blurred 20.86 10.03 823 557565 128199 109902712
Hospitalisation 20.77 10.03 899 557489 141594 109889317
Human herpesvirus 6 infection 20.76 10.03 4 558384 6577 110024334
Hepatitis B reactivation 20.75 10.03 6 558382 7478 110023433
Lung opacity 20.73 10.03 17 558371 11635 110019276
Gastric polyps 20.50 10.03 68 558320 5455 110025456
Uveitis 20.37 10.03 50 558338 21660 110009251
Electrocardiogram ST segment elevation 20.36 10.03 96 558292 9064 110021847
Immobile 20.36 10.03 85 558303 7617 110023294
Upper respiratory tract infection 20.31 10.03 506 557882 130822 109900089
Left atrial dilatation 20.16 10.03 51 558337 3509 110027402
Postural orthostatic tachycardia syndrome 20.14 10.03 35 558353 1847 110029064
Hypocholesterolaemia 20.05 10.03 4 558384 6417 110024494
Cytomegalovirus viraemia 19.93 10.03 37 558351 17727 110013184
Hypotonia 19.87 10.03 142 558246 15603 110015308
Aplastic anaemia 19.80 10.03 60 558328 24248 110006663
Systemic candida 19.76 10.03 13 558375 9961 110020950
Osteoporosis 19.75 10.03 315 558073 86837 109944074
Cerebellar haemorrhage 19.73 10.03 48 558340 3223 110027688
Cardiac flutter 19.72 10.03 69 558319 5688 110025223
Blood creatinine abnormal 19.65 10.03 70 558318 5822 110025089
Pleuritic pain 19.58 10.03 32 558356 16108 110014803
Iliac artery stenosis 19.56 10.03 13 558375 217 110030694
Alveolitis 19.56 10.03 58 558330 4381 110026530
Anticoagulation drug level below therapeutic 19.54 10.03 33 558355 1701 110029210
Skin hypertrophy 19.51 10.03 63 558325 4984 110025927
Ovarian cyst 19.48 10.03 25 558363 13905 110017006
Monoclonal immunoglobulin present 19.48 10.03 41 558347 2499 110028412
Cerebrospinal fluid retention 19.46 10.03 10 558378 100 110030811
Aggression 19.39 10.03 198 558190 59012 109971899
Herpes simplex 19.37 10.03 31 558357 15733 110015178
Ischaemia 19.32 10.03 94 558294 8989 110021922
Colorectal cancer 19.28 10.03 11 558377 9103 110021808
Gouty arthritis 19.27 10.03 32 558356 1627 110029284
Status epilepticus 19.13 10.03 88 558300 31483 109999428
Stress cardiomyopathy 19.06 10.03 141 558247 15665 110015246
Carcinoid tumour 19.05 10.03 19 558369 576 110030335
Eye haemorrhage 19.03 10.03 113 558275 11661 110019250
Enzyme inhibition 18.99 10.03 11 558377 142 110030769
Adjustment disorder 18.90 10.03 16 558372 10779 110020132
Haemoptysis 18.88 10.03 483 557905 70871 109960040
Neuroleptic malignant syndrome 18.87 10.03 98 558290 33961 109996950
CD30 expression 18.82 10.03 9 558379 76 110030835
Pineal gland cyst 18.82 10.03 13 558375 232 110030679
Albumin urine present 18.69 10.03 21 558367 732 110030179
Hypovolaemic shock 18.69 10.03 132 558256 14451 110016460
Ulcer 18.68 10.03 134 558254 42982 109987929
Pulmonary vasculitis 18.67 10.03 5 558383 6555 110024356
Wound infection pseudomonas 18.58 10.03 39 558349 2372 110028539
Extra dose administered 18.57 10.03 115 558273 12044 110018867
Diabetic nephropathy 18.57 10.03 49 558339 3459 110027452
Electrocardiogram T wave inversion 18.53 10.03 67 558321 5613 110025298
Nocturia 18.50 10.03 148 558240 16842 110014069
Glomerulonephritis rapidly progressive 18.45 10.03 37 558351 2178 110028733
Computerised tomogram head abnormal 18.41 10.03 10 558378 113 110030798
Echolalia 18.39 10.03 18 558370 533 110030378
Drug dose omission by device 18.35 10.03 28 558360 14488 110016423
Venous pressure jugular increased 18.35 10.03 28 558360 1324 110029587
Amenorrhoea 18.33 10.03 12 558376 9219 110021692
Facial bones fracture 18.27 10.03 61 558327 4910 110026001
Device dislocation 18.26 10.03 90 558298 31614 109999297
Actinic keratosis 18.23 10.03 77 558311 6936 110023975
Renal atrophy 18.14 10.03 38 558350 2308 110028603
Haemoglobin abnormal 18.14 10.03 92 558296 8946 110021965
N-terminal prohormone brain natriuretic peptide increased 18.14 10.03 70 558318 6051 110024860
Nasal oedema 18.03 10.03 6 558382 6833 110024078
Obsessive-compulsive disorder 17.99 10.03 7 558381 7234 110023677
Arteriospasm coronary 17.82 10.03 92 558296 9008 110021903
Flank pain 17.82 10.03 187 558201 22943 110007968
Macrophages increased 17.81 10.03 13 558375 254 110030657
Parathyroid hormone-related protein abnormal 17.79 10.03 6 558382 17 110030894
Calciphylaxis 17.78 10.03 54 558334 4133 110026778
Metabolic encephalopathy 17.78 10.03 106 558282 10954 110019957
Hemiparesis 17.71 10.03 316 558072 43587 109987324
Neuroglycopenia 17.71 10.03 25 558363 1101 110029810
End stage renal disease 17.69 10.03 176 558212 21297 110009614
Cardiovascular somatic symptom disorder 17.69 10.03 7 558381 35 110030876
Jaundice cholestatic 17.69 10.03 29 558359 14579 110016332
Cellulitis 17.69 10.03 792 557596 125224 109905687
Blood electrolytes decreased 17.64 10.03 32 558356 1747 110029164
Skin fibrosis 17.61 10.03 28 558360 1372 110029539
Intentional overdose 17.57 10.03 828 557560 131673 109899238
Sepsis 17.54 10.03 1899 556489 325447 109705464
Lung infiltration 17.54 10.03 196 558192 24432 110006479
Renal cell carcinoma 17.53 10.03 80 558308 7450 110023461
Eczema 17.51 10.03 258 558130 72035 109958876
Cardiovascular insufficiency 17.48 10.03 46 558342 3242 110027669
Anticoagulant therapy 17.47 10.03 3 558385 5358 110025553
Malignant polyp 17.45 10.03 11 558377 167 110030744
Sprue-like enteropathy 17.45 10.03 31 558357 1665 110029246
Pustular psoriasis 17.44 10.03 26 558362 13579 110017332
Hepatojugular reflux 17.40 10.03 20 558368 715 110030196
Blood triglycerides increased 17.30 10.03 191 558197 23735 110007176
Dysstasia 17.29 10.03 248 558140 32738 109998173
Thrombotic microangiopathy 17.22 10.03 82 558306 29067 110001844
Blood glucose abnormal 17.19 10.03 118 558270 12798 110018113
Intracardiac thrombus 17.16 10.03 54 558334 4214 110026697
Aortic valve disease 17.14 10.03 36 558352 2191 110028720
Tachycardia induced cardiomyopathy 17.09 10.03 12 558376 220 110030691
Transplant rejection 17.04 10.03 65 558323 24502 110006409
Thoracic haemorrhage 17.01 10.03 13 558375 273 110030638
Hyperparathyroidism 17.00 10.03 50 558338 3760 110027151
Leukoencephalopathy 16.88 10.03 13 558375 9182 110021729
Non-high-density lipoprotein cholesterol increased 16.84 10.03 15 558373 393 110030518
Incision site pain 16.81 10.03 44 558344 3091 110027820
Atrial conduction time prolongation 16.78 10.03 8 558380 67 110030844
Enterocolitis 16.74 10.03 45 558343 18904 110012007
Defaecation disorder 16.74 10.03 21 558367 824 110030087
Conjunctivitis allergic 16.73 10.03 7 558381 6924 110023987
Rhinovirus infection 16.65 10.03 21 558367 11768 110019143
Muscle rupture 16.63 10.03 55 558333 4405 110026506
Injection site erythema 16.48 10.03 356 558032 93820 109937091
Pollakiuria 16.40 10.03 314 558074 43881 109987030
Nail pitting 16.40 10.03 16 558372 472 110030439
Portal fibrosis 16.38 10.03 19 558369 686 110030225
Metastases to lymph nodes 16.26 10.03 32 558356 15000 110015911
Left ventricular enlargement 16.23 10.03 21 558367 850 110030061
Skin laceration 16.22 10.03 250 558138 33503 109997408
Arteriosclerotic gangrene 16.20 10.03 8 558380 73 110030838
Blood pressure immeasurable 16.18 10.03 37 558351 2386 110028525
Hepatic cyst 16.17 10.03 80 558308 7703 110023208
Product administration interrupted 16.13 10.03 105 558283 11187 110019724
Rhinitis 16.06 10.03 59 558329 22486 110008425
Rebound tachycardia 16.03 10.03 6 558382 25 110030886
Blood bicarbonate abnormal 16.03 10.03 10 558378 149 110030762
Electrocardiogram ST-T change 16.01 10.03 29 558359 1581 110029330
Asthma-chronic obstructive pulmonary disease overlap syndrome 15.98 10.03 6 558382 6338 110024573
Aplasia 15.95 10.03 10 558378 7863 110023048
Coma 15.91 10.03 463 557925 117406 109913505
Renal transplant 15.91 10.03 44 558344 3194 110027717
Peripheral circulatory failure 15.90 10.03 31 558357 1788 110029123
Dermatitis atopic 15.86 10.03 198 558190 25343 110005568
Thrombosis in device 15.85 10.03 61 558327 5266 110025645
Foetal death 15.82 10.03 36 558352 16009 110014902
Aortic valve replacement 15.81 10.03 29 558359 1597 110029314
Strongyloidiasis 15.79 10.03 3 558385 4983 110025928
Mechanical urticaria 15.75 10.03 17 558371 566 110030345
Ecchymosis 15.71 10.03 145 558243 17193 110013718
Disseminated intravascular coagulation 15.70 10.03 133 558255 41153 109989758
Hypoalbuminaemia 15.70 10.03 84 558304 28890 110002021
Anticoagulation drug level increased 15.69 10.03 22 558366 963 110029948
Hypertransaminasaemia 15.67 10.03 66 558322 24189 110006722
Aspiration pleural cavity 15.67 10.03 30 558358 1707 110029204
Oral pain 15.64 10.03 271 558117 37173 109993738
N-terminal prohormone brain natriuretic peptide abnormal 15.62 10.03 13 558375 310 110030601
Neuritis 15.55 10.03 9 558379 7390 110023521
Subacute cutaneous lupus erythematosus 15.53 10.03 58 558330 4936 110025975
Joint dislocation 15.43 10.03 105 558283 34085 109996826
Cell death 15.41 10.03 5 558383 5786 110025125
Polyuria 15.40 10.03 147 558241 17591 110013320
Lymphocyte count decreased 15.40 10.03 200 558188 57043 109973868
Fluid intake reduced 15.37 10.03 73 558315 6913 110023998
Kyphosis 15.36 10.03 43 558345 3144 110027767
Medication overuse headache 15.35 10.03 28 558360 1535 110029376
Carbuncle 15.33 10.03 27 558361 1440 110029471
Prostatic specific antigen increased 15.31 10.03 112 558276 12399 110018512
Hallucination, visual 15.26 10.03 283 558105 39322 109991589
Wound dehiscence 15.25 10.03 80 558308 7882 110023029
Visual field defect 15.22 10.03 95 558293 9977 110020934
Feeling hot 15.20 10.03 347 558041 90759 109940152
Mitral valve hypoplasia 15.16 10.03 6 558382 30 110030881
Shone complex 15.16 10.03 6 558382 30 110030881
Heart valve replacement 15.16 10.03 24 558364 1172 110029739
Tuberculosis 15.11 10.03 43 558345 17731 110013180
Dyschromatopsia 15.08 10.03 25 558363 1269 110029642
Bacterial infection 15.05 10.03 154 558234 45882 109985029
Foreign body 15.02 10.03 41 558347 2954 110027957
Inhibitory drug interaction 15.01 10.03 57 558331 4890 110026021
Congenital aortic valve stenosis 15.00 10.03 6 558382 31 110030880
Neutrophil function disorder 15.00 10.03 6 558382 31 110030880
Upper motor neurone lesion 14.90 10.03 13 558375 331 110030580
Thrombocytopenia 14.88 10.03 1538 556850 347347 109683564
Metabolic syndrome 14.86 10.03 43 558345 3204 110027707
Endocarditis 14.85 10.03 117 558271 13254 110017657
Blood pressure orthostatic 14.84 10.03 8 558380 89 110030822
Arteriovenous fistula occlusion 14.82 10.03 16 558372 533 110030378
Hepatitis B 14.78 10.03 16 558372 9596 110021315
Drug clearance decreased 14.64 10.03 50 558338 4072 110026839
Ocular icterus 14.61 10.03 65 558323 5988 110024923
Myocardial necrosis marker increased 14.61 10.03 48 558340 3832 110027079
Spinal epidural haematoma 14.59 10.03 29 558359 1696 110029215
Needle issue 14.59 10.03 146 558242 17694 110013217
Respiratory tract infection 14.56 10.03 264 558124 71353 109959558
Overweight 14.55 10.03 68 558320 6396 110024515
Aorta hypoplasia 14.55 10.03 6 558382 34 110030877
Polyomavirus-associated nephropathy 14.55 10.03 12 558376 8189 110022722
Total cholesterol/HDL ratio increased 14.54 10.03 14 558374 406 110030505
Metastatic renal cell carcinoma 14.54 10.03 36 558352 2444 110028467
Chronic gastritis 14.52 10.03 60 558328 5351 110025560
Nocardiosis 14.50 10.03 10 558378 7476 110023435
Disseminated tuberculosis 14.50 10.03 4 558384 5142 110025769
Pneumatosis intestinalis 14.50 10.03 13 558375 8516 110022395
Intentional self-injury 14.49 10.03 120 558268 37309 109993602
Patent ductus arteriosus 14.45 10.03 10 558378 179 110030732
Metastases to fallopian tube 14.45 10.03 7 558381 61 110030850
Hyperbilirubinaemia 14.44 10.03 93 558295 30578 110000333
Silent myocardial infarction 14.41 10.03 18 558370 703 110030208
Urinary tract obstruction 14.37 10.03 58 558330 5119 110025792
Sinus arrhythmia 14.34 10.03 33 558355 2137 110028774
Sarcoidosis 14.29 10.03 26 558362 12553 110018358
Central nervous system lupus 14.27 10.03 25 558363 1328 110029583
Psychomotor skills impaired 14.25 10.03 9 558379 7049 110023862
Intestinal haemorrhage 14.23 10.03 74 558314 7267 110023644
Diffuse large B-cell lymphoma recurrent 14.21 10.03 7 558381 6292 110024619
Angioplasty 14.18 10.03 31 558357 1940 110028971
Poor peripheral circulation 14.11 10.03 50 558338 4147 110026764
Cardiac fibrillation 14.11 10.03 22 558366 1060 110029851
BK virus infection 14.09 10.03 28 558360 13078 110017833
Penile haemorrhage 14.05 10.03 20 558368 888 110030023
Carcinoid tumour of the small bowel 13.99 10.03 14 558374 426 110030485
Heart disease congenital 13.99 10.03 17 558371 645 110030266
Pleural mass 13.96 10.03 8 558380 101 110030810
Palpable purpura 13.94 10.03 15 558373 498 110030413
Hyperammonaemic encephalopathy 13.93 10.03 5 558383 5429 110025482
Poor quality sleep 13.89 10.03 209 558179 27868 110003043
Left-to-right cardiac shunt 13.89 10.03 10 558378 191 110030720
Pneumonia cytomegaloviral 13.86 10.03 9 558379 6945 110023966
Aphasia 13.79 10.03 393 557995 58604 109972307
Mite allergy 13.79 10.03 6 558382 5797 110025114
Sacroiliitis 13.78 10.03 4 558384 4974 110025937
Glycosylated haemoglobin increased 13.78 10.03 181 558207 23438 110007473
Biopsy lymph gland 13.76 10.03 8 558380 104 110030807
Dermatitis acneiform 13.76 10.03 27 558361 12668 110018243
Congenital heart valve disorder 13.74 10.03 6 558382 40 110030871
Cerebral infarction 13.74 10.03 351 558037 51487 109979424
Acute lymphocytic leukaemia recurrent 13.72 10.03 6 558382 5781 110025130
Gait disturbance 13.68 10.03 1605 556783 276603 109754308
Multiple drug therapy 13.66 10.03 78 558310 7936 110022975
Loss of control of legs 13.63 10.03 32 558356 2100 110028811
Weight decreased 13.62 10.03 2621 555767 465436 109565475
Conjunctival cyst 13.62 10.03 7 558381 70 110030841
Bacterial parotitis 13.62 10.03 6 558382 41 110030870
Skin abrasion 13.61 10.03 133 558255 16018 110014893
Embolic cerebral infarction 13.57 10.03 26 558362 1480 110029431
Brain natriuretic peptide increased 13.52 10.03 100 558288 11109 110019802
Atrial tachycardia 13.52 10.03 86 558302 9092 110021819
Kidney rupture 13.51 10.03 11 558377 254 110030657
Troponin I increased 13.51 10.03 59 558329 5393 110025518
Atrioventricular dissociation 13.39 10.03 13 558375 381 110030530
Hypertensive nephropathy 13.39 10.03 21 558367 1017 110029894
Depression 13.38 10.03 1400 556988 315935 109714976
Wrong product administered 13.35 10.03 98 558290 10862 110020049
Poor venous access 13.33 10.03 71 558317 24451 110006460
JC virus infection 13.33 10.03 5 558383 5285 110025626
Aneurysm 13.30 10.03 51 558337 4395 110026516
Fracture blisters 13.29 10.03 7 558381 74 110030837
Acne 13.19 10.03 107 558281 33413 109997498
Polymyositis 13.19 10.03 45 558343 3663 110027248
Abdominal pain 13.17 10.03 2334 556054 510655 109520256
Catatonia 13.16 10.03 23 558365 11277 110019634
Histology abnormal 13.14 10.03 13 558375 390 110030521
Depression suicidal 13.13 10.03 4 558384 4820 110026091
Acute graft versus host disease in intestine 13.13 10.03 6 558382 5633 110025278
Inferior vena cava syndrome 13.13 10.03 8 558380 114 110030797
Splenic rupture 13.12 10.03 36 558352 2601 110028310
Herbal interaction 13.11 10.03 16 558372 610 110030301
Splenic injury 13.09 10.03 11 558377 266 110030645
Malignant hypertension 13.07 10.03 27 558361 1624 110029287
Device use error 13.03 10.03 16 558372 9073 110021838
Skin discolouration 12.97 10.03 332 558056 48714 109982197
Encephalitis 12.97 10.03 50 558338 18789 110012122
Radiotherapy to brain 12.93 10.03 6 558382 47 110030864
Scan myocardial perfusion abnormal 12.91 10.03 9 558379 163 110030748
Hyperpyrexia 12.89 10.03 13 558375 8056 110022855
Hereditary haemochromatosis 12.88 10.03 3 558385 0 110030911
Alveolar-arterial oxygen gradient increased 12.88 10.03 3 558385 0 110030911
Venous pressure jugular abnormal 12.88 10.03 3 558385 0 110030911
Drug screen 12.88 10.03 3 558385 0 110030911
Electrocardiogram P wave biphasic 12.88 10.03 3 558385 0 110030911
Dysphagia 12.88 10.03 921 557467 152679 109878232
Irritability 12.87 10.03 167 558221 47642 109983269
Duodenitis 12.83 10.03 85 558303 9111 110021800
Left ventricular false tendon 12.82 10.03 6 558382 48 110030863
Coronary artery insufficiency 12.82 10.03 9 558379 165 110030746
Coronary ostial stenosis 12.82 10.03 9 558379 165 110030746
Paternal exposure during pregnancy 12.81 10.03 10 558378 217 110030694
Blood creatine phosphokinase MB abnormal 12.80 10.03 5 558383 24 110030887
Iron deficiency 12.74 10.03 49 558339 18427 110012484
Erythema multiforme 12.67 10.03 59 558329 21038 110009873
Disorientation 12.67 10.03 456 557932 70215 109960696
Acute myeloid leukaemia 12.66 10.03 127 558261 37983 109992928
Disability assessment scale score increased 12.64 10.03 3 558385 4267 110026644
Drug dependence 12.64 10.03 177 558211 49843 109981068
Congenital aortic stenosis 12.64 10.03 5 558383 25 110030886
Congenital aortic anomaly 12.64 10.03 5 558383 25 110030886
Encephalopathy 12.63 10.03 515 557873 80540 109950371
Stillbirth 12.62 10.03 3 558385 4261 110026650
Autoimmune myocarditis 12.61 10.03 16 558372 635 110030276
Vascular device infection 12.58 10.03 42 558346 16470 110014441
Labile blood pressure 12.56 10.03 34 558354 2437 110028474
Cardiac function test abnormal 12.54 10.03 9 558379 171 110030740
Small fibre neuropathy 12.54 10.03 20 558368 983 110029928
Disease progression 12.51 10.03 1061 557327 242973 109787938
Lumbar vertebral fracture 12.50 10.03 84 558304 9047 110021864
Myocardial bridging 12.48 10.03 5 558383 26 110030885
Organising pneumonia 12.45 10.03 34 558354 14209 110016702
Lichenification 12.45 10.03 20 558368 989 110029922
Cardiac amyloidosis 12.44 10.03 37 558351 2800 110028111
Hallucination 12.43 10.03 629 557759 100803 109930108
Congestive cardiomyopathy 12.43 10.03 118 558270 14101 110016810
Blood magnesium decreased 12.41 10.03 155 558233 19841 110011070
Electrocardiogram ST-T segment abnormal 12.38 10.03 19 558369 903 110030008
Intermittent claudication 12.37 10.03 44 558344 3657 110027254
Product contamination 12.36 10.03 29 558359 1902 110029009
Vasoconstriction 12.34 10.03 21 558367 1089 110029822
Therapeutic response shortened 12.31 10.03 93 558295 29490 110001421
Urine output decreased 12.31 10.03 154 558234 19722 110011189
Oesophageal achalasia 12.27 10.03 20 558368 1001 110029910
Arterial stenosis 12.26 10.03 26 558362 1593 110029318
Radiculopathy 12.26 10.03 53 558335 19283 110011628
Mesenteric haemorrhage 12.24 10.03 7 558381 88 110030823
Dermatitis exfoliative generalised 12.18 10.03 23 558365 10949 110019962
Scan gallium abnormal 12.17 10.03 5 558383 28 110030883
Traumatic haemorrhage 12.14 10.03 28 558360 1816 110029095
Shock hypoglycaemic 12.14 10.03 10 558378 235 110030676
Psychiatric decompensation 12.13 10.03 7 558381 5758 110025153
Bladder neck obstruction 12.11 10.03 7 558381 90 110030821
Sodium retention 12.10 10.03 10 558378 236 110030675
Precancerous skin lesion 12.09 10.03 26 558362 1608 110029303
Cardiac discomfort 12.07 10.03 24 558364 1404 110029507
Gastric cyst 12.04 10.03 7 558381 91 110030820
Supravalvular aortic stenosis 12.03 10.03 5 558383 29 110030882
Hypothyroidism 12.01 10.03 466 557922 72433 109958478
Therapeutic response unexpected 12 10.03 178 558210 23665 110007246
Traumatic haematoma 12.00 10.03 33 558355 2388 110028523
Pseudolymphoma 11.97 10.03 22 558366 1213 110029698
Soft tissue haemorrhage 11.97 10.03 13 558375 436 110030475
Subdural haemorrhage 11.95 10.03 65 558323 6493 110024418
Hiatus hernia strangulated 11.95 10.03 11 558377 301 110030610
Secretion discharge 11.93 10.03 57 558331 20187 110010724
Mesenteric vascular insufficiency 11.91 10.03 8 558380 136 110030775
Tricuspid valve sclerosis 11.89 10.03 5 558383 30 110030881
Atrial septal defect 11.88 10.03 31 558357 2174 110028737
Peripartum cardiomyopathy 11.86 10.03 9 558379 187 110030724
Myasthenia gravis 11.85 10.03 62 558326 21449 110009462
Eye injury 11.82 10.03 13 558375 7742 110023169
Neutropenic colitis 11.78 10.03 14 558374 8051 110022860
Chest wall haematoma 11.74 10.03 14 558374 521 110030390
Femoral pulse decreased 11.69 10.03 4 558384 12 110030899
Necrotising myositis 11.67 10.03 29 558359 1973 110028938
Myxoedema 11.65 10.03 10 558378 249 110030662
Cytomegalovirus test positive 11.63 10.03 11 558377 7025 110023886
Refusal of treatment by patient 11.62 10.03 85 558303 9409 110021502
Prerenal failure 11.62 10.03 49 558339 4410 110026501
Leukocytosis 11.61 10.03 355 558033 53473 109977438
Pulmonary thrombosis 11.60 10.03 114 558274 13749 110017162
Preternatural anus 11.59 10.03 7 558381 98 110030813
Hyperphosphataemia 11.58 10.03 43 558345 16338 110014573
Abdominal pain upper 11.57 10.03 1565 556823 347546 109683365
Increased viscosity of bronchial secretion 11.52 10.03 15 558373 611 110030300
Increased tendency to bruise 11.51 10.03 100 558288 11658 110019253
Sickle cell anaemia with crisis 11.51 10.03 19 558369 9526 110021385
Blood ketone body increased 11.50 10.03 18 558370 870 110030041
Paranoia 11.50 10.03 66 558322 22308 110008603
Therapeutic drug monitoring analysis incorrectly performed 11.48 10.03 16 558372 696 110030215
Erythema nodosum 11.48 10.03 10 558378 6643 110024268
Electrocardiogram T wave alternans 11.47 10.03 8 558380 145 110030766
Nausea 11.46 10.03 6619 551769 1229071 108801840
Cerebrovascular disorder 11.46 10.03 43 558345 3668 110027243
Fear of injection 11.45 10.03 17 558371 8894 110022017
Brugada syndrome 11.45 10.03 25 558363 1563 110029348
Oedema due to cardiac disease 11.43 10.03 6 558382 63 110030848
Paradoxical drug reaction 11.42 10.03 20 558368 9797 110021114
Left ventricular end-diastolic pressure increased 11.38 10.03 16 558372 702 110030209
Tumour lysis syndrome 11.36 10.03 100 558288 30701 110000210
Renal artery stenosis 11.36 10.03 43 558345 3683 110027228
Electrocardiogram P wave abnormal 11.35 10.03 12 558376 390 110030521
Total cholesterol/HDL ratio decreased 11.34 10.03 6 558382 64 110030847
Intracranial aneurysm 11.33 10.03 53 558335 4987 110025924
Blood alkaline phosphatase abnormal 11.33 10.03 22 558366 1265 110029646
Petechiae 11.32 10.03 173 558215 23144 110007767
Nodular rash 11.26 10.03 11 558377 325 110030586
Transfusion 11.24 10.03 186 558202 25286 110005625
Mini mental status examination abnormal 11.23 10.03 4 558384 14 110030897
Acquired mixed hyperlipidaemia 11.23 10.03 4 558384 14 110030897
Intestinal angioedema 11.22 10.03 20 558368 1077 110029834
Aortic aneurysm rupture 11.20 10.03 23 558365 1377 110029534
Sluggishness 11.20 10.03 71 558317 7496 110023415
Sensory loss 11.19 10.03 63 558325 21394 110009517
Chemical burn of oral cavity 11.19 10.03 6 558382 66 110030845
Unwanted awareness during anaesthesia 11.18 10.03 12 558376 397 110030514
Retinal vascular disorder 11.18 10.03 12 558376 397 110030514
Myelodysplastic syndrome unclassifiable 11.18 10.03 7 558381 105 110030806
Pelvic fracture 11.17 10.03 115 558273 14039 110016872
Mesenteric arterial occlusion 11.16 10.03 10 558378 264 110030647
Splenic haemorrhage 11.15 10.03 17 558371 803 110030108
Optic ischaemic neuropathy 11.14 10.03 46 558342 4101 110026810
Pulse abnormal 11.13 10.03 46 558342 4103 110026808
Tongue discomfort 11.12 10.03 36 558352 2852 110028059
Hyperammonaemia 11.11 10.03 34 558354 13698 110017213
Apallic syndrome 11.10 10.03 20 558368 1086 110029825
Intentional product misuse 11.07 10.03 553 557835 132351 109898560
Conjunctivitis 11.06 10.03 113 558275 33679 109997232
Hyperthermia malignant 11.05 10.03 3 558385 3897 110027014
Hypertensive encephalopathy 11.03 10.03 21 558367 1190 110029721
Respiratory tract congestion 11.03 10.03 101 558287 30756 110000155
Reduced facial expression 11.02 10.03 42 558346 3609 110027302
Autoimmune haemolytic anaemia 11.00 10.03 23 558365 10544 110020367
Antiacetylcholine receptor antibody positive 10.98 10.03 10 558378 270 110030641
Radiation overdose 10.96 10.03 6 558382 69 110030842
Coarctation of the aorta 10.96 10.03 6 558382 69 110030842
Cyanopsia 10.95 10.03 7 558381 109 110030802
Cardiac aneurysm 10.95 10.03 26 558362 1719 110029192
Injection site pain 10.93 10.03 762 557626 177160 109853751
Central nervous system injury 10.93 10.03 8 558380 157 110030754
Pseudomonas infection 10.92 10.03 89 558299 27764 110003147
Pseudomonal sepsis 10.92 10.03 18 558370 9028 110021883
Cardiac stress test abnormal 10.90 10.03 17 558371 819 110030092
Menstruation irregular 10.89 10.03 8 558380 5789 110025122
Dyslipidaemia 10.89 10.03 126 558262 15839 110015072
Vascular pseudoaneurysm 10.89 10.03 46 558342 4144 110026767
Ventricular dysfunction 10.83 10.03 70 558318 7441 110023470
Episcleral venous pressure increased 10.82 10.03 4 558384 16 110030895
Arrhythmia supraventricular 10.82 10.03 32 558356 2414 110028497
Pacemaker syndrome 10.82 10.03 3 558385 3 110030908
Non-small cell lung cancer stage IIIA 10.82 10.03 3 558385 3 110030908
Paronychia 10.81 10.03 25 558363 11056 110019855
Haemorrhagic arteriovenous malformation 10.79 10.03 14 558374 568 110030343
Depressed level of consciousness 10.79 10.03 681 557707 111597 109919314
Hypoaldosteronism 10.74 10.03 15 558373 654 110030257
Vascular access site occlusion 10.74 10.03 7 558381 113 110030798
Purpura 10.73 10.03 178 558210 24210 110006701
Thrombotic thrombocytopenic purpura 10.70 10.03 67 558321 7044 110023867
Affect lability 10.68 10.03 53 558335 18584 110012327
Rash vesicular 10.67 10.03 38 558350 14614 110016297
Acute pulmonary oedema 10.66 10.03 132 558256 16864 110014047
Sinus rhythm 10.65 10.03 19 558369 1024 110029887
Malignant neoplasm of eye 10.63 10.03 7 558381 115 110030796
International normalised ratio 10.63 10.03 7 558381 115 110030796
Diffuse mesangial sclerosis 10.59 10.03 6 558382 74 110030837
Bundle branch block bilateral 10.58 10.03 7 558381 116 110030795
Gastroenteritis bacterial 10.56 10.03 13 558375 500 110030411
Faecal calprotectin increased 10.54 10.03 11 558377 6708 110024203
Drug tolerance increased 10.51 10.03 14 558374 583 110030328
Muscle haemorrhage 10.51 10.03 65 558323 6804 110024107
Large intestine benign neoplasm 10.47 10.03 8 558380 168 110030743
Pulse pressure decreased 10.46 10.03 12 558376 428 110030483
Hyperlactacidaemia 10.46 10.03 16 558372 8270 110022641
Oesophageal carcinoma 10.46 10.03 27 558361 11497 110019414
Post procedural complication 10.45 10.03 191 558197 26467 110004444
Antithyroid arthritis syndrome 10.45 10.03 4 558384 18 110030893
Angiocardiogram 10.42 10.03 10 558378 289 110030622
Hypertriglyceridaemia 10.41 10.03 44 558344 16110 110014801
Juvenile idiopathic arthritis 10.40 10.03 9 558379 5998 110024913
Apnoea 10.38 10.03 110 558278 13529 110017382
Dyspnoea at rest 10.38 10.03 75 558313 8271 110022640
Arterial perforation 10.38 10.03 5 558383 43 110030868
Traumatic intracranial haemorrhage 10.37 10.03 23 558365 1453 110029458
Glomerular filtration rate abnormal 10.37 10.03 31 558357 2352 110028559
Posterior reversible encephalopathy syndrome 10.37 10.03 115 558273 33746 109997165
Borrelia test positive 10.36 10.03 3 558385 4 110030907
Galactorrhoea 10.35 10.03 4 558384 4151 110026760
Intervertebral discitis 10.35 10.03 12 558376 6978 110023933
Phonophobia 10.33 10.03 15 558373 678 110030233
Facial asymmetry 10.33 10.03 18 558370 952 110029959
Abnormal behaviour 10.28 10.03 137 558251 38902 109992009
Ascites 10.28 10.03 374 558014 92434 109938477
Shoshin beriberi 10.26 10.03 6 558382 79 110030832
Central nervous system lesion 10.25 10.03 42 558346 15511 110015400
Lipodystrophy acquired 10.25 10.03 5 558383 4519 110026392
Toxic cataract 10.11 10.03 4 558384 20 110030891
Abdominal bruit 10.11 10.03 4 558384 20 110030891
Anal fistula 10.09 10.03 17 558371 8456 110022455
Allergic reaction to excipient 10.08 10.03 16 558372 783 110030128
Tooth disorder 10.06 10.03 207 558181 29302 110001609
Hypertrophic cardiomyopathy 10.06 10.03 37 558351 3126 110027785
Ventricular dyskinesia 10.05 10.03 12 558376 447 110030464
Dyskinesia 10.04 10.03 191 558197 51255 109979656

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neonatal respiratory failure 48.35 28.31 35 1241 289 112388

Pharmacologic Action:

SourceCodeDescription
ATC C07AB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07BB52 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07CB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07FB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D013565 Sympatholytics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35530 ฮฒ-adrenergic antagonist
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:176497 geroprotector
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

C07AB Beta blocking agents, selective 13 drugs
acebutololatenololbetaxololbevantololbisoprololceliprololepanololesatenololesmolollandiololnebivololpractolol show all 13 →
C07BB Beta blocking agents, selective, and thiazides 5 drugs
acebutololatenololbevantololbisoprololnebivolol
C07CB Beta blocking agents, selective, and other diuretics 1 drug
atenolol
C07FB Beta blocking agents and calcium channel blockers 6 drugs
amlodipineatenololbisoprololfelodipinenebivololnifedipine
C07FX Beta blocking agents, other combinations 6 drugs
acetylsalicylic acidbisoprololcarvedilolivabradinepropranololsotalol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Angina pectoris indication 194828000
Acute coronary syndrome indication 394659003
Myocardial Reinfarction Prevention indication
Supraventricular tachycardia off-label use 6456007
Ventricular tachycardia off-label use 25569003
Atrial fibrillation off-label use 49436004 DOID:0060224
Multifocal atrial tachycardia off-label use 49982000
Paroxysmal supraventricular tachycardia off-label use 67198005
Thyrotoxicosis off-label use 90739004 DOID:7997
Paroxysmal atrial tachycardia off-label use 195069001
Ectopic atrial tachycardia off-label use 233892002
Mitral valve prolapse off-label use 409712001
Diastolic heart failure off-label use 418304008 DOID:9775
Migraine Prevention off-label use
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Pheochromocytoma Adjunct Therapy off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Myasthenia gravis contraindication 91637004 DOID:437
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Azotemia contraindication 445009001
Acute exacerbation of asthma contraindication 708038006
First Degree Atrioventricular Heart Block contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.60 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.30 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.79 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.83 CHEMBL
Adrenergic receptor beta GPCR IC50 6.30 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 7.31 CHEMBL

External reference:

IDSource
D00601 KEGG_DRUG
80274-67-5 SECONDARY_CAS_RN
98418-47-4 SECONDARY_CAS_RN
56392-17-7 SECONDARY_CAS_RN
4018393 VANDF
4019836 VANDF
4020875 VANDF
C0025859 UMLSCUI
CHEBI:6904 CHEBI
CHEMBL13 ChEMBL_ID
CHEMBL3989566 ChEMBL_ID
CHEMBL2356097 ChEMBL_ID
CHEMBL2062335 ChEMBL_ID
DB00264 DRUGBANK_ID
D008790 MESH_DESCRIPTOR_UI
4171 PUBCHEM_CID
553 IUPHAR_LIGAND_ID
3471 INN_ID
GEB06NHM23 UNII
102313 RXNORM
1073 MMSL
400080 MMSL
5102 MMSL
5103 MMSL
d00134 MMSL
001853 NDDF
003627 NDDF
003628 NDDF
004135 NDDF
372826007 SNOMEDCT_US
412432007 SNOMEDCT_US
7092007 SNOMEDCT_US
72770009 SNOMEDCT_US
GEB06NHM23 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9660 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 27 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9873 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 27 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0018 TABLET, FILM COATED 25 mg ORAL ANDA 29 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0032 TABLET, FILM COATED 50 mg ORAL ANDA 29 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0047 TABLET, FILM COATED 100 mg ORAL ANDA 29 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0424 TABLET 50 mg ORAL ANDA 25 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0434 TABLET 100 mg ORAL ANDA 25 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0445 TABLET 100 mg ORAL ANDA 25 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4593 TABLET, FILM COATED 37.50 mg ORAL ANDA 29 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4594 TABLET, FILM COATED 75 mg ORAL ANDA 29 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4595 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 27 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4596 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL ANDA 27 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4597 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL ANDA 27 sections
Metoprolol Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4598 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL ANDA 27 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1778 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 32 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-2016 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 32 sections
Metoprolol succinate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7823 TABLET, EXTENDED RELEASE 25 mg ORAL ANDA 24 sections
Metoprolol succinate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7824 TABLET, EXTENDED RELEASE 50 mg ORAL ANDA 24 sections
Metoprolol succinate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7825 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 24 sections
METOPROLOL TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8421 TABLET 25 mg ORAL ANDA 26 sections
METOPROLOL TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8422 TABLET 50 mg ORAL ANDA 26 sections
METOPROLOL TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8423 TABLET 100 mg ORAL ANDA 26 sections
Metoprolol succinate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6322 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 24 sections
Metoprolol succinate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6323 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL ANDA 24 sections
Metoprolol succinate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6324 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL ANDA 24 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-124 TABLET 50 mg ORAL ANDA 26 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-263 TABLET, FILM COATED 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-298 TABLET, FILM COATED 25 mg ORAL ANDA 22 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-553 TABLET 100 mg ORAL ANDA 26 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-879 TABLET, FILM COATED 50 mg ORAL ANDA 15 sections