benzydamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3881	642-72-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzydamine HCl benzydamine hydrochloride benzydamide benzydamine benzidamine benzindamine	A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat. Molecular weight: 309.41 Formula: C19H23N3O CLOGP: 4.29 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 30.29 ALOGS: -3.80 ROTB: 7

Molecule

Description

Molfile Inchi Smiles

Synonyms:

benzydamine HCl
benzydamine hydrochloride
benzydamide
benzydamine
benzidamine
benzindamine

A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.

Molecular weight: 309.41
Formula: C19H23N3O
CLOGP: 4.29
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 30.29
ALOGS: -3.80
ROTB: 7

Drug dosage:

Dose	Unit	Route
0.15	g	O
0.15	g	R
9	mg	O

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	87 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)	8.10 hours	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.28 mL/min/kg	Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)	1.53 L/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.80 %	Lombardo F, Berellini G, Obach RS

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Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	156.45	38.16	63	5168	24313	63459478
Mouth ulceration	144.44	38.16	65	5166	32919	63450872
Skin candida	137.45	38.16	31	5200	1624	63482167
Neutropenic sepsis	135.64	38.16	51	5180	16387	63467404
Mucosal inflammation	111.45	38.16	61	5170	46867	63436924
Vaginal flatulence	106.83	38.16	29	5202	3264	63480527
Hypomagnesaemia	102.04	38.16	49	5182	28688	63455103
Chronic sinusitis	99.27	38.16	38	5193	12805	63470986
Proctitis	92.45	38.16	29	5202	5412	63478379
Constipation	89.44	38.16	101	5130	224842	63258949

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neutropenic sepsis	68.16	40.02	22	932	13745	34942232

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neutropenic sepsis	178.43	35.62	70	6073	26994	79711251
Mouth ulceration	164.40	35.62	73	6070	38321	79699924
Skin candida	127.10	35.62	30	6113	2057	79736188
Vaginal flatulence	110.86	35.62	28	6115	2547	79735698
Mucosal inflammation	102.81	35.62	67	6076	75513	79662732
Macular degeneration	102.73	35.62	37	6106	11259	79726986
Chronic sinusitis	97.59	35.62	37	6106	12989	79725256
Constipation	88.84	35.62	109	6034	282941	79455304
Female genital tract fistula	87.55	35.62	28	6115	5947	79732298
Proctitis	85.52	35.62	28	6115	6404	79731841

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A01AD02	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Other agents for local oral treatment
ATC	G02CC03	GENITO URINARY SYSTEM AND SEX HORMONES OTHER GYNECOLOGICALS OTHER GYNECOLOGICALS Antiinflammatory products for vaginal administration
ATC	M01AX07	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Other antiinflammatory and antirheumatic agents, non-steroids
ATC	M02AA05	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
ATC	R02AX03	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Other throat preparations
CHEBI has role	CHEBI:35337	analeptic
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:35499	hallucinogens
CHEBI has role	CHEBI:36333	local anesthetics
MeSH PA	D000893	Anti-Inflammatory Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pain	indication	22253000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.78	Basic
pKa2	1.65	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Soluble guanylate cyclase	Enzyme	O75343 P33402 Q02108 Q02153	GCYB2_HUMAN GCYA2_HUMAN GCYA3_HUMAN GCYB1_HUMAN		EC50	5.99		CHEMBL

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External reference:

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ID	Source
003474	NDDF
004658	NDDF
12555	PUBCHEM_CID
132-69-4	SECONDARY_CAS_RN
1425	RXNORM
1927	INN_ID
331143003	SNOMEDCT_US
350307000	SNOMEDCT_US
421319000	SNOMEDCT_US
4O21U048EF	UNII

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Pharmaceutical products:

None