candesartan cilexetil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin II receptor antagonists, antihypertensive (non-peptidic) 475 145040-37-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • candesartan cilexetil
  • TCV-116
  • TCV 116
a nonpeptide angiotensin II receptor antagonist
  • Molecular weight: 610.67
  • Formula: C33H34N6O6
  • CLOGP: 7.08
  • LIPINSKI: 3
  • HAC: 12
  • HDO: 1
  • TPSA: 143.34
  • ALOGS: -5.48
  • ROTB: 13
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.05 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.61 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
June 4, 1998 FDA ASTRAZENECA
March 12, 1999 PMDA Takeda Pharmaceutical Company Limited

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 413.73 10.54 898 63051 227160 50314015
Hyponatraemia 306.15 10.54 483 63466 95656 50445519
Hyperkalaemia 190.79 10.54 268 63681 47821 50493354
General physical health deterioration 175.48 10.54 484 63465 141950 50399225
Drug ineffective 170.04 10.54 505 63444 818828 49722347
Completed suicide 125.96 10.54 11 63938 131878 50409297
Synovitis 124.91 10.54 8 63941 123857 50417318
Oligohydramnios 121.62 10.54 81 63868 5669 50535506
Angina pectoris 117.54 10.54 155 63794 26033 50515142
Product dose omission issue 117.06 10.54 43 63906 183795 50357380
Hand deformity 112.51 10.54 3 63946 100196 50440979
Glossodynia 112.11 10.54 9 63940 115560 50425615
Maternal exposure during pregnancy 107.56 10.54 34 63915 159744 50381431
Arthropathy 103.83 10.54 35 63914 157871 50383304
Bradycardia 102.16 10.54 241 63708 64185 50476990
Alopecia 95.85 10.54 101 63848 244946 50296229
Swelling 95.23 10.54 69 63880 200803 50340372
Drug interaction 92.76 10.54 497 63452 199124 50342051
Renal impairment 90.96 10.54 255 63694 75406 50465769
Syncope 84.27 10.54 304 63645 102698 50438477
Cough 82.24 10.54 554 63395 240710 50300465
Haematochezia 81.19 10.54 165 63784 39717 50501458
Cardiac failure 80.58 10.54 245 63704 75795 50465380
Drug hypersensitivity 79.89 10.54 121 63828 250889 50290286
Systemic lupus erythematosus 79.71 10.54 39 63910 140583 50400592
Pain 79.26 10.54 420 63529 578483 49962692
Blood pressure increased 77.86 10.54 354 63595 132778 50408397
Sputum discoloured 77.35 10.54 90 63859 13305 50527870
Death 77.23 10.54 187 63762 325192 50215983
Pericarditis 76.66 10.54 6 63943 78683 50462492
Fall 76.55 10.54 701 63248 334231 50206944
Hypotension 73.35 10.54 529 63420 234940 50306235
Neovascularisation 72.29 10.54 32 63917 981 50540194
Anuria 70.77 10.54 79 63870 11165 50530010
Injection site pain 70.57 10.54 26 63923 110998 50430177
Arterial occlusive disease 70.07 10.54 54 63895 4754 50536421
Blood creatinine increased 67.64 10.54 231 63718 75929 50465246
Product use issue 67.41 10.54 54 63895 149421 50391754
Dizziness 66.45 10.54 699 63250 345670 50195505
Lactic acidosis 65.53 10.54 136 63813 33219 50507956
Abdominal discomfort 65.06 10.54 121 63828 231520 50309655
Hypertensive crisis 63.93 10.54 81 63868 13073 50528102
Joint swelling 61.34 10.54 137 63812 245149 50296026
Contraindicated product administered 60.92 10.54 59 63890 148899 50392276
Product prescribing error 60.71 10.54 101 63848 20860 50520315
Anaemia 60.47 10.54 534 63415 251922 50289253
Rubber sensitivity 60.08 10.54 34 63915 1775 50539400
Product monitoring error 58.60 10.54 39 63910 2725 50538450
Atrial fibrillation 55.38 10.54 265 63684 101480 50439695
Orthostatic hypotension 55.35 10.54 118 63831 29363 50511812
Inappropriate antidiuretic hormone secretion 54.70 10.54 75 63874 13068 50528107
Dyspnoea 52.96 10.54 978 62971 546630 49994545
Hypoglycaemia 52.46 10.54 168 63781 53413 50487762
Drug intolerance 51.07 10.54 127 63822 218977 50322198
Labile hypertension 50.89 10.54 20 63929 451 50540724
Wound 50.53 10.54 36 63913 105758 50435417
Hepatic enzyme increased 49.96 10.54 60 63889 137320 50403855
Infusion related reaction 49.89 10.54 86 63863 169471 50371704
Rash 46.94 10.54 342 63607 437129 50104046
Peripheral swelling 46.73 10.54 121 63828 205815 50335360
Infection 46.22 10.54 93 63856 172861 50368314
Sinusitis 46.19 10.54 91 63858 170467 50370708
Gangrene 44.22 10.54 41 63908 4651 50536524
Gastrointestinal disorder 43.99 10.54 33 63916 94423 50446752
Injection site erythema 42.11 10.54 21 63928 74915 50466260
Discomfort 41.94 10.54 45 63904 108335 50432840
Basilar artery occlusion 41.64 10.54 12 63937 98 50541077
Circulatory collapse 40.99 10.54 83 63866 19917 50521258
Forced expiratory volume decreased 40.65 10.54 38 63911 4356 50536819
Cerebral infarction 40.01 10.54 86 63863 21518 50519657
Skin haemorrhage 39.14 10.54 46 63903 6872 50534303
Helicobacter infection 38.35 10.54 8 63941 49694 50491481
Androgenetic alopecia 37.81 10.54 12 63937 140 50541035
Lung opacity 37.46 10.54 26 63923 1947 50539228
Vertigo 36.58 10.54 146 63803 51686 50489489
Paradoxical drug reaction 36.58 10.54 33 63916 3614 50537561
Disorientation 36.32 10.54 113 63836 35371 50505804
Oedema peripheral 35.64 10.54 330 63619 157631 50383544
Fibromyalgia 35.20 10.54 7 63942 44971 50496204
Cholestatic liver injury 34.59 10.54 25 63924 1996 50539179
Neurologic neglect syndrome 34.40 10.54 22 63927 1436 50539739
Renal failure 33.95 10.54 241 63708 106392 50434783
Gamma-glutamyltransferase increased 33.78 10.54 98 63851 29525 50511650
Diffuse alopecia 33.65 10.54 16 63933 580 50540595
Injection site reaction 33.01 10.54 11 63938 50021 50491154
Pemphigoid 32.96 10.54 39 63910 5868 50535307
Hypersensitivity 31.62 10.54 152 63797 215009 50326166
Palpitations 31.50 10.54 216 63733 94290 50446885
Occupational asthma 31.48 10.54 10 63939 117 50541058
Carotid artery thrombosis 31.42 10.54 21 63928 1478 50539697
Productive cough 31.41 10.54 141 63808 52553 50488622
Haematoma 31.08 10.54 97 63852 30413 50510762
Non-cardiogenic pulmonary oedema 30.99 10.54 15 63934 566 50540609
Off label use 30.67 10.54 419 63530 474007 50067168
Aphasia 30.33 10.54 92 63857 28402 50512773
Drug ineffective for unapproved indication 29.87 10.54 76 63873 21205 50519970
Systemic infection 29.73 10.54 24 63925 2259 50538916
Chromaturia 29.25 10.54 60 63889 14530 50526645
Arthralgia 29.23 10.54 385 63564 438317 50102858
Treatment failure 28.86 10.54 84 63865 137553 50403622
Tubulointerstitial nephritis 28.68 10.54 61 63888 15150 50526025
Rheumatoid arthritis 28.66 10.54 145 63804 202405 50338770
Heart rate 28.47 10.54 8 63941 59 50541116
Ill-defined disorder 28.26 10.54 17 63932 54637 50486538
Toxicity to various agents 27.91 10.54 156 63793 212343 50328832
Hypomagnesaemia 27.75 10.54 78 63871 23078 50518097
Vertigo positional 27.74 10.54 24 63925 2487 50538688
Hospitalisation 27.65 10.54 27 63922 67910 50473265
Mobility decreased 26.90 10.54 37 63912 79911 50461264
Vestibular migraine 26.24 10.54 10 63939 207 50540968
Therapy non-responder 26.20 10.54 16 63933 51006 50490169
Lichen planus 26.19 10.54 21 63928 1958 50539217
Sensitivity to weather change 26.12 10.54 35 63914 5966 50535209
Dehydration 26.06 10.54 301 63648 152148 50389027
Arrhythmia 25.55 10.54 96 63853 33036 50508139
Gastrointestinal tract adenoma 25.55 10.54 11 63938 315 50540860
Therapeutic product effect incomplete 25.47 10.54 48 63901 91467 50449708
Oesophageal dilatation 25.32 10.54 11 63938 322 50540853
Intraventricular haemorrhage 25.08 10.54 20 63929 1850 50539325
Blood hyposmosis 25.05 10.54 6 63943 21 50541154
Therapeutic product effect decreased 25.04 10.54 88 63861 135962 50405213
Haematoma muscle 25.04 10.54 14 63935 714 50540461
Confusional state 24.95 10.54 351 63598 185577 50355598
Blood pressure measurement 24.90 10.54 10 63939 239 50540936
C-reactive protein abnormal 24.77 10.54 3 63946 27806 50513369
Hemiplegia 24.71 10.54 38 63911 7343 50533832
International normalised ratio increased 24.63 10.54 114 63835 43038 50498137
Total lung capacity decreased 24.48 10.54 17 63932 1274 50539901
Rhabdomyolysis 24.45 10.54 106 63843 38921 50502254
Malaise 24.34 10.54 575 63374 334957 50206218
Barotrauma 24.00 10.54 9 63940 178 50540997
Irritable bowel syndrome 23.91 10.54 18 63931 51423 50489752
Mental status changes 23.88 10.54 8 63941 36264 50504911
Pulmonary hypoplasia 23.43 10.54 10 63939 280 50540895
Purpura senile 23.32 10.54 12 63937 517 50540658
Extrapyramidal disorder 23.12 10.54 48 63901 11722 50529453
Obstructive airways disorder 23.12 10.54 57 63892 15595 50525580
Respiratory tract inflammation 23.09 10.54 12 63937 528 50540647
Intentional overdose 23.02 10.54 27 63922 62477 50478698
Myalgia 22.85 10.54 249 63700 124070 50417105
No adverse event 22.83 10.54 7 63942 33571 50507604
Internal haemorrhage 22.74 10.54 28 63921 4389 50536786
Transaminases increased 22.62 10.54 82 63867 27742 50513433
Osteochondrosis 22.15 10.54 15 63934 1079 50540096
Disturbance in attention 22.12 10.54 88 63861 31098 50510077
Cerebellar syndrome 22.11 10.54 24 63925 3287 50537888
Tinnitus 22.10 10.54 82 63867 28050 50513125
Vasoplegia syndrome 21.90 10.54 15 63934 1099 50540076
Exposure during pregnancy 21.79 10.54 79 63870 120936 50420239
Altered state of consciousness 21.71 10.54 69 63880 21841 50519334
Adjustment disorder 21.70 10.54 19 63930 2000 50539175
Hemiparesis 21.59 10.54 65 63884 19983 50521192
Acute myocardial infarction 21.08 10.54 83 63866 29190 50511985
Impaired healing 20.87 10.54 35 63914 69751 50471424
Melaena 20.85 10.54 78 63871 26786 50514389
Occult blood 20.82 10.54 15 63934 1192 50539983
Mental status changes postoperative 20.58 10.54 8 63941 175 50541000
Intravascular haemolysis 20.39 10.54 9 63940 274 50540901
Sinus arrest 20.33 10.54 17 63932 1681 50539494
Injection site swelling 20.22 10.54 14 63935 41759 50499416
Adverse drug reaction 20.18 10.54 24 63925 55198 50485977
Sinonasal obstruction 20.09 10.54 8 63941 187 50540988
Multiple sclerosis relapse 20.01 10.54 15 63934 42949 50498226
Cornea verticillata 19.92 10.54 6 63943 58 50541117
Drug abuse 19.82 10.54 28 63921 59818 50481357
Pneumobilia 19.81 10.54 7 63942 116 50541059
Confusion postoperative 19.78 10.54 8 63941 195 50540980
Cerebral haemorrhage 19.72 10.54 77 63872 26975 50514200
Blood uric acid increased 19.25 10.54 24 63925 3810 50537365
Painful respiration 19.07 10.54 19 63930 2356 50538819
Glomerular filtration rate decreased 18.90 10.54 44 63905 11608 50529567
Nausea 18.76 10.54 1079 62870 704319 49836856
Bronchopulmonary aspergillosis allergic 18.73 10.54 14 63935 1177 50539998
Blister 18.73 10.54 51 63898 85367 50455808
Renal tubular disorder 18.66 10.54 19 63930 2418 50538757
Decreased appetite 18.65 10.54 357 63592 200566 50340609
Gastrointestinal haemorrhage 18.48 10.54 157 63792 73164 50468011
Therapeutic response changed 18.26 10.54 12 63937 821 50540354
Blood pressure inadequately controlled 18.23 10.54 25 63924 4355 50536820
Injection site bruising 18.23 10.54 12 63937 36756 50504419
Dermatosis 18.17 10.54 8 63941 242 50540933
Female sterilisation 17.96 10.54 10 63939 506 50540669
Renal impairment neonatal 17.90 10.54 5 63944 36 50541139
Hepatic function abnormal 17.67 10.54 85 63864 32596 50508579
Psoriatic arthropathy 17.66 10.54 20 63929 47012 50494163
Iron deficiency anaemia 17.59 10.54 54 63895 16780 50524395
Gastroenteritis 17.57 10.54 67 63882 23214 50517961
Tarsal tunnel syndrome 17.55 10.54 10 63939 529 50540646
Cystitis 17.38 10.54 106 63843 44458 50496717
Vomiting 17.05 10.54 728 63221 460030 50081145
Histamine intolerance 17.02 10.54 5 63944 44 50541131
Dyspnoea at rest 17.00 10.54 22 63927 3625 50537550
Wrong strength 16.92 10.54 5 63944 45 50541130
Putamen haemorrhage 16.88 10.54 7 63942 182 50540993
Neuropathy peripheral 16.87 10.54 64 63885 96693 50444482
Blood creatine phosphokinase increased 16.81 10.54 72 63877 26295 50514880
Product quality issue 16.81 10.54 9 63940 30849 50510326
Subarachnoid haemorrhage 16.72 10.54 40 63909 10736 50530439
Iron deficiency 16.64 10.54 28 63921 5834 50535341
Psoas abscess 16.61 10.54 9 63940 431 50540744
Prothrombin time shortened 16.55 10.54 15 63934 1652 50539523
Diabetic ketoacidosis 16.55 10.54 55 63894 17817 50523358
Hypokalaemia 16.51 10.54 177 63772 87815 50453360
Injection site pruritus 16.51 10.54 16 63933 40395 50500780
Spider naevus 16.42 10.54 6 63943 110 50541065
Asthenia 16.38 10.54 523 63426 318519 50222656
Interstitial lung disease 16.23 10.54 119 63830 53057 50488118
Potentiating drug interaction 16.22 10.54 22 63927 3794 50537381
Knee arthroplasty 16.08 10.54 13 63936 35833 50505342
Cor pulmonale acute 16.05 10.54 8 63941 322 50540853
Eosinophilia 16.04 10.54 56 63893 18596 50522579
Vestibular disorder 15.81 10.54 13 63936 1256 50539919
Hypoventilation 15.75 10.54 22 63927 3899 50537276
Disease progression 15.70 10.54 65 63884 95801 50445374
Blepharospasm 15.68 10.54 19 63930 2929 50538246
Agranulocytosis 15.64 10.54 61 63888 21360 50519815
Glossitis 15.60 10.54 18 63931 2637 50538538
Walking disability 15.57 10.54 13 63936 1283 50539892
Chest wall mass 15.48 10.54 5 63944 62 50541113
Abortion spontaneous 15.43 10.54 18 63931 41754 50499421
Musculoskeletal stiffness 15.43 10.54 97 63852 128384 50412791
Renal aplasia 15.42 10.54 7 63942 228 50540947
Accidental exposure to product 15.33 10.54 5 63944 23052 50518123
Labelled drug-drug interaction medication error 15.31 10.54 38 63911 10439 50530736
Urogenital haemorrhage 15.17 10.54 7 63942 237 50540938
Brain stem stroke 15.11 10.54 7 63942 239 50540936
Microcytic anaemia 15.00 10.54 19 63930 3065 50538110
Visual acuity reduced transiently 14.96 10.54 6 63943 143 50541032
Haematemesis 14.91 10.54 72 63877 27653 50513522
Pain in jaw 14.81 10.54 16 63933 38412 50502763
Atrioventricular block complete 14.74 10.54 30 63919 7225 50533950
Full blood count decreased 14.59 10.54 5 63944 22341 50518834
Lip infection 14.55 10.54 5 63944 76 50541099
Upper gastrointestinal haemorrhage 14.54 10.54 49 63900 15986 50525189
C-reactive protein increased 14.53 10.54 138 63811 66336 50474839
Skin texture abnormal 14.51 10.54 8 63941 397 50540778
Intentional product misuse 14.38 10.54 23 63926 46711 50494464
Breast discomfort 14.36 10.54 8 63941 405 50540770
Cardiorenal syndrome 14.32 10.54 9 63940 570 50540605
Binocular eye movement disorder 14.18 10.54 4 63945 30 50541145
Hyperuricaemia 14.15 10.54 23 63926 4657 50536518
Lower respiratory tract infection 14.11 10.54 67 63882 95134 50446041
Retroperitoneal fibrosis 13.95 10.54 7 63942 286 50540889
Device issue 13.87 10.54 4 63945 19968 50521207
Epilepsy 13.83 10.54 59 63890 21508 50519667
Ultrasound kidney abnormal 13.74 10.54 4 63945 34 50541141
Laryngeal papilloma 13.74 10.54 3 63946 6 50541169
Spinal osteoarthritis 13.61 10.54 44 63905 14048 50527127
Haemorrhagic cyst 13.61 10.54 6 63943 182 50540993
Anaemia folate deficiency 13.58 10.54 6 63943 183 50540992
Coronavirus test positive 13.55 10.54 9 63940 627 50540548
Respiratory tract congestion 13.42 10.54 44 63905 14155 50527020
Flatulence 13.40 10.54 73 63876 29385 50511790
Urinary retention 13.36 10.54 67 63882 26123 50515052
Fluid intake reduced 13.27 10.54 18 63931 3104 50538071
Sputum retention 13.26 10.54 8 63941 471 50540704
Nasal congestion 13.20 10.54 28 63921 51092 50490083
Aortic dissection 13.19 10.54 13 63936 1590 50539585
Cardiac murmur functional 13.16 10.54 4 63945 40 50541135
Metastases to fallopian tube 13.16 10.54 4 63945 40 50541135
Laryngeal dysplasia 13.14 10.54 3 63946 8 50541167
Abdominal pain 13.11 10.54 391 63558 235837 50305338
Wrong technique in product usage process 13.04 10.54 32 63917 55478 50485697
Adverse event 13.03 10.54 22 63927 43741 50497434
Cholestasis 12.97 10.54 65 63884 25336 50515839
Therapeutic response decreased 12.94 10.54 25 63924 47206 50493969
Hypochloraemia 12.90 10.54 13 63936 1634 50539541
Thirst 12.88 10.54 36 63913 10614 50530561
Decreased ventricular preload 12.88 10.54 3 63946 9 50541166
Endometrial cancer 12.83 10.54 17 63932 2866 50538309
Suicide attempt 12.81 10.54 29 63920 51703 50489472
Sneezing 12.81 10.54 43 63906 14001 50527174
Transient ischaemic attack 12.80 10.54 77 63872 32133 50509042
Polyneuropathy 12.75 10.54 39 63910 12092 50529083
Personality disorder 12.74 10.54 21 63928 4303 50536872
Multiple sclerosis 12.68 10.54 5 63944 20488 50520687
Eczema nummular 12.63 10.54 6 63943 217 50540958
Gastroenteritis viral 12.62 10.54 4 63945 18782 50522393
Neonatal hypotension 12.55 10.54 5 63944 117 50541058
Cystitis escherichia 12.52 10.54 7 63942 357 50540818
Drug therapeutic incompatibility 12.50 10.54 4 63945 48 50541127
Staphylococcal infection 12.47 10.54 16 63933 35600 50505575
Vital capacity decreased 12.34 10.54 10 63939 946 50540229
Treatment noncompliance 12.24 10.54 12 63937 30138 50511037
Hallucinations, mixed 12.19 10.54 20 63929 4083 50537092
Ear infection 12.18 10.54 9 63940 25961 50515214
Body temperature increased 12.13 10.54 13 63936 31328 50509847
Urticaria 12.11 10.54 105 63844 129456 50411719
Paresis 12.10 10.54 14 63935 2057 50539118
Hepatitis cholestatic 12.08 10.54 25 63924 6092 50535083
Pharyngeal enanthema 12.07 10.54 4 63945 54 50541121
Drug metabolising enzyme decreased 12.02 10.54 3 63946 13 50541162
Taste disorder 11.96 10.54 30 63919 8294 50532881
Cold sweat 11.93 10.54 35 63914 10609 50530566
Resorption bone increased 11.85 10.54 10 63939 1001 50540174
Chemotherapeutic drug level increased 11.85 10.54 5 63944 136 50541039
Flail chest 11.81 10.54 4 63945 58 50541117
Muscular weakness 11.79 10.54 177 63772 94836 50446339
Leiomyoma 11.77 10.54 7 63942 401 50540774
Injection site rash 11.69 10.54 3 63946 16174 50525001
COVID-19 11.68 10.54 26 63923 46636 50494539
White blood cell count decreased 11.63 10.54 93 63856 116629 50424546
Nocturia 11.56 10.54 26 63923 6704 50534471
Pancreatitis acute 11.51 10.54 60 63889 23752 50517423
Thalamus haemorrhage 11.49 10.54 8 63941 602 50540573
Intentional product use issue 11.47 10.54 54 63895 76864 50464311
Cerebral haematoma 11.41 10.54 17 63932 3194 50537981
Depression 11.40 10.54 144 63805 165279 50375896
Lordosis 11.40 10.54 6 63943 271 50540904
Weight increased 11.36 10.54 183 63766 201708 50339467
Rales 11.36 10.54 33 63916 9945 50531230
Lung perforation 11.34 10.54 4 63945 66 50541109
Ischaemic stroke 11.31 10.54 45 63904 15903 50525272
Stasis dermatitis 11.27 10.54 8 63941 621 50540554
Wheezing 11.26 10.54 124 63825 61923 50479252
Subdural haematoma 11.24 10.54 39 63910 12908 50528267
Ventricular extrasystoles 11.23 10.54 34 63915 10482 50530693
Sinus congestion 11.20 10.54 41 63908 13930 50527245
Proteinuria 11.11 10.54 46 63903 16551 50524624
Gastritis bacterial 11.07 10.54 4 63945 71 50541104
Foetal malformation 11.04 10.54 5 63944 162 50541013
Electrolyte imbalance 11.03 10.54 47 63902 17122 50524053
Jaundice 11.03 10.54 64 63885 26365 50514810
Vertebrobasilar insufficiency 11.01 10.54 4 63945 72 50541103
Dysarthria 11.01 10.54 83 63866 37320 50503855
Therapy cessation 10.97 10.54 10 63939 26001 50515174
Joint injury 10.95 10.54 7 63942 21782 50519393
Laboratory test abnormal 10.94 10.54 8 63941 23200 50517975
Base excess decreased 10.91 10.54 4 63945 74 50541101
Microangiopathy 10.91 10.54 9 63940 874 50540301
Phlebitis 10.85 10.54 23 63926 5697 50535478
Uterine dilation and evacuation 10.81 10.54 3 63946 21 50541154
Musculoskeletal pain 10.79 10.54 139 63810 72038 50469137
Drug monitoring procedure not performed 10.74 10.54 7 63942 472 50540703
Device dislocation 10.72 10.54 7 63942 21539 50519636
Blood sodium decreased 10.72 10.54 54 63895 21093 50520082
Incarcerated incisional hernia 10.69 10.54 3 63946 22 50541153
Delayed fontanelle closure 10.69 10.54 3 63946 22 50541153
Joint range of motion decreased 10.68 10.54 5 63944 18507 50522668
Pregnancy 10.65 10.54 13 63936 29564 50511611
Hypoosmolar state 10.60 10.54 5 63944 178 50540997
Motor dysfunction 10.57 10.54 28 63921 8003 50533172

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 192.77 10.18 486 48820 102371 29422850
Hyperkalaemia 165.12 10.18 335 48971 61057 29464164
Acute kidney injury 159.38 10.18 865 48441 264402 29260819
Death 149.83 10.18 212 49094 341872 29183349
Product monitoring error 125.22 10.18 69 49237 2576 29522645
Completed suicide 116.31 10.18 9 49297 90237 29434984
Toxicity to various agents 91.30 10.18 93 49213 173568 29351653
Product prescribing error 85.01 10.18 126 49180 17850 29507371
Product dose omission issue 80.51 10.18 30 49276 96353 29428868
Haematochezia 78.99 10.18 184 49122 36799 29488422
Bradycardia 73.82 10.18 259 49047 65370 29459851
Drug abuse 73.52 10.18 21 49285 79862 29445359
Drug ineffective 69.41 10.18 341 48965 362829 29162392
Angina pectoris 56.67 10.18 136 49170 27714 29497507
Neutropenia 56.03 10.18 83 49223 131628 29393593
Blood cholesterol 55.23 10.18 18 49288 170 29525051
Renal impairment 51.05 10.18 269 49037 81064 29444157
Labelled drug-drug interaction medication error 48.77 10.18 79 49227 12080 29513141
Dizziness 48.45 10.18 506 48800 189178 29336043
Pulmonary hypoplasia 47.47 10.18 20 49286 406 29524815
Renal artery stenosis 46.57 10.18 33 49273 1928 29523293
Cardiac failure 44.89 10.18 255 49051 79032 29446189
Off label use 44.22 10.18 307 48999 300493 29224728
Myalgia 42.52 10.18 239 49067 73780 29451441
Gastrointestinal angiodysplasia 42.12 10.18 20 49286 543 29524678
Lymphocyte count abnormal 40.08 10.18 20 49286 607 29524614
Presyncope 39.90 10.18 85 49221 16004 29509217
Blood creatinine increased 39.50 10.18 260 49046 84842 29440379
Dyspnoea 39.33 10.18 763 48543 325969 29199252
Drug hypersensitivity 36.60 10.18 36 49270 68370 29456851
Oedema peripheral 35.84 10.18 295 49011 103262 29421959
Interstitial lung disease 35.58 10.18 190 49116 57528 29467693
Disease progression 34.43 10.18 52 49254 81864 29443357
Multiple drug therapy 33.60 10.18 15 49291 352 29524869
Renal artery thrombosis 33.38 10.18 14 49292 281 29524940
Sepsis 33.23 10.18 124 49182 142558 29382663
Neuropathy peripheral 31.91 10.18 43 49263 70984 29454237
Anencephaly 31.69 10.18 11 49295 128 29525093
Febrile neutropenia 31.34 10.18 90 49216 112150 29413071
Hospitalisation 31.20 10.18 19 49287 45969 29479252
Electrolyte imbalance 30.81 10.18 62 49244 11212 29514009
Jaundice 30.67 10.18 113 49193 29183 29496038
Agitation 29.82 10.18 25 49281 51279 29473942
Renal cyst haemorrhage 29.12 10.18 14 49292 391 29524830
Cerebral infarction 29.11 10.18 99 49207 24576 29500645
Adrenal insufficiency 29.05 10.18 60 49246 11054 29514167
Patient dissatisfaction with treatment 28.93 10.18 9 49297 72 29525149
Blood pressure inadequately controlled 28.69 10.18 27 49279 2359 29522862
Pemphigoid 27.38 10.18 47 49259 7534 29517687
Arrhythmia 27.28 10.18 114 49192 31199 29494022
Seizure 27.24 10.18 73 49233 93050 29432171
Vena cava injury 26.88 10.18 11 49295 207 29525014
Hypoxia 25.26 10.18 25 49281 47354 29477867
Intraductal papillary mucinous neoplasm 25.20 10.18 12 49294 328 29524893
Cardiac arrest 25.10 10.18 67 49239 85524 29439697
Aortic valve incompetence 24.94 10.18 36 49270 4977 29520244
Pneumonia 24.90 10.18 380 48926 319792 29205429
Glycosylated haemoglobin increased 24.77 10.18 51 49255 9375 29515846
Lactic acidosis 24.71 10.18 108 49198 30139 29495082
Peripheral arterial occlusive disease 24.59 10.18 36 49270 5040 29520181
Rectal prolapse 24.57 10.18 11 49295 260 29524961
Hypotension 23.66 10.18 455 48851 193899 29331322
Actinic keratosis 23.08 10.18 30 49276 3756 29521465
Mental status changes 22.90 10.18 15 49291 34912 29490309
SARS-CoV-2 antibody test positive 22.87 10.18 10 49296 223 29524998
Joint contracture 22.86 10.18 21 49285 1779 29523442
Treatment failure 22.72 10.18 17 49289 36922 29488299
Hypertensive crisis 22.46 10.18 44 49262 7804 29517417
Gastrointestinal ischaemia 22.41 10.18 9 49297 161 29525060
Lung hernia 21.88 10.18 7 49299 62 29525159
Respiratory arrest 21.61 10.18 8 49298 25825 29499396
Diverticulum intestinal 21.52 10.18 27 49279 3263 29521958
Post concussion syndrome 21.52 10.18 8 49298 115 29525106
Renal artery angioplasty 21.52 10.18 5 49301 10 29525211
Renal artery stent placement 21.52 10.18 5 49301 10 29525211
Hyperuricaemia 21.41 10.18 40 49266 6849 29518372
Blood creatine phosphokinase increased 20.58 10.18 127 49179 40517 29484704
Acute cutaneous lupus erythematosus 20.36 10.18 7 49299 79 29525142
Nervous system neoplasm 19.62 10.18 8 49298 149 29525072
Costovertebral angle tenderness 19.54 10.18 7 49299 90 29525131
Hemiataxia 19.51 10.18 6 49300 46 29525175
Anxiety disorder due to a general medical condition 19.36 10.18 4 49302 3 29525218
Vasculitic rash 19.32 10.18 14 49292 847 29524374
Rhabdomyolysis 19.31 10.18 170 49136 60638 29464583
Sedation 19.22 10.18 3 49303 17402 29507819
Urinary hesitation 19.21 10.18 21 49285 2192 29523029
Atrioventricular block second degree 19.15 10.18 25 49281 3143 29522078
Food aversion 19.05 10.18 10 49296 338 29524883
White blood cell count decreased 19.02 10.18 73 49233 83289 29441932
Tonsillar ulcer 19.01 10.18 8 49298 162 29525059
Oral lichen planus 18.96 10.18 8 49298 163 29525058
Total cholesterol/HDL ratio increased 18.96 10.18 8 49298 163 29525058
Intentional product misuse 18.81 10.18 18 49288 34643 29490578
Abdominal pain lower 18.45 10.18 43 49263 8595 29516626
Hyperparathyroidism secondary 18.42 10.18 16 49290 1259 29523962
Drug dependence 18.41 10.18 6 49300 20975 29504246
Acute right ventricular failure 18.03 10.18 7 49299 114 29525107
Product use in unapproved indication 17.99 10.18 79 49227 86796 29438425
Blood growth hormone increased 17.86 10.18 9 49297 279 29524942
Gamma-glutamyltransferase increased 17.83 10.18 90 49216 26647 29498574
Ventricular extrasystoles 17.70 10.18 48 49258 10534 29514687
Congenital renal disorder 17.59 10.18 6 49300 66 29525155
Drug resistance 17.47 10.18 7 49299 21533 29503688
pH body fluid increased 17.35 10.18 6 49300 69 29525152
Macular ischaemia 17.35 10.18 6 49300 69 29525152
Sinusitis 17.32 10.18 19 49287 34331 29490890
Drug interaction 17.31 10.18 441 48865 196944 29328277
Paresis cranial nerve 17.27 10.18 6 49300 70 29525151
Eczema eyelids 17.17 10.18 5 49301 31 29525190
Full blood count decreased 17.11 10.18 3 49303 15989 29509232
Haematuria 17.03 10.18 129 49177 44010 29481211
Coronavirus infection 16.93 10.18 24 49282 3264 29521957
Vertebral artery stenosis 16.80 10.18 7 49299 138 29525083
Xanthopsia 16.48 10.18 7 49299 145 29525076
Diabetic nephropathy 16.48 10.18 18 49288 1877 29523344
Incarcerated inguinal hernia 16.41 10.18 6 49300 82 29525139
Device lead damage 16.20 10.18 3 49303 0 29525221
Hypochromic anaemia 16.19 10.18 12 49294 752 29524469
Congenital muscle absence 16.18 10.18 5 49301 39 29525182
Congenital vas deferens absence 16.18 10.18 5 49301 39 29525182
Plasma cell myeloma 16.13 10.18 23 49283 37092 29488129
Mucosal haemorrhage 16.01 10.18 16 49290 1505 29523716
Respiratory symptom 16 10.18 13 49293 933 29524288
Abdominal wall haemorrhage 15.87 10.18 8 49298 248 29524973
Choroidal detachment 15.81 10.18 9 49297 358 29524863
Muscle rupture 15.71 10.18 18 49288 1979 29523242
Unevaluable event 15.62 10.18 16 49290 29835 29495386
Renovascular hypertension 15.60 10.18 4 49302 14 29525207
Shock hypoglycaemic 15.55 10.18 6 49300 96 29525125
Pancreatitis acute 15.51 10.18 81 49225 24304 29500917
Hallucination 15.50 10.18 32 49274 44680 29480541
Coronary artery stenosis 15.47 10.18 40 49266 8533 29516688
Basilar artery thrombosis 15.42 10.18 7 49299 171 29525050
Hepatic ischaemia 15.37 10.18 9 49297 378 29524843
Bronchopulmonary aspergillosis allergic 15.36 10.18 10 49296 508 29524713
No adverse event 15.33 10.18 5 49301 17473 29507748
Mixed liver injury 15.32 10.18 18 49288 2033 29523188
Cardiovascular insufficiency 15.31 10.18 15 49291 1378 29523843
Neuroleptic malignant syndrome 15.30 10.18 4 49302 16144 29509077
Respiratory failure 15.27 10.18 97 49209 97034 29428187
Therapeutic product effect decreased 15.17 10.18 16 49290 29435 29495786
Retinal artery occlusion 15.14 10.18 16 49290 1607 29523614
Neurotoxicity 15.08 10.18 3 49303 14610 29510611
Carotid arteriosclerosis 14.90 10.18 15 49291 1423 29523798
Blood pressure increased 14.78 10.18 188 49118 73615 29451606
Mesenteric artery thrombosis 14.70 10.18 9 49297 410 29524811
Idiopathic pulmonary fibrosis 14.67 10.18 22 49284 3146 29522075
Therapy non-responder 14.61 10.18 18 49288 30893 29494328
Metabolic acidosis 14.49 10.18 110 49196 37552 29487669
Supine hypertension 14.39 10.18 8 49298 304 29524917
Oligohydramnios 14.36 10.18 8 49298 305 29524916
Bronchiectasis 14.30 10.18 33 49273 6552 29518669
Generalised tonic-clonic seizure 14.30 10.18 7 49299 19132 29506089
Anti-erythropoietin antibody negative 14.29 10.18 7 49299 204 29525017
Basal cell carcinoma 14.29 10.18 61 49245 16849 29508372
Hepatic steatosis 14.28 10.18 56 49250 14890 29510331
Aortic valve stenosis 14.25 10.18 18 49288 2190 29523031
Peritoneal adhesions 14.14 10.18 6 49300 124 29525097
Syncope 14.12 10.18 202 49104 81169 29444052
Cytomegalovirus infection 13.87 10.18 11 49295 23204 29502017
Pterygium 13.84 10.18 6 49300 131 29525090
Lymphocyte count 13.77 10.18 5 49301 67 29525154
Bacteraemia 13.75 10.18 5 49301 16318 29508903
Desmoplastic melanoma 13.71 10.18 4 49302 25 29525196
Obstructive airways disorder 13.70 10.18 45 49261 10971 29514250
Basal ganglia haemorrhage 13.59 10.18 11 49295 785 29524436
Papillary renal cell carcinoma 13.59 10.18 6 49300 137 29525084
Adverse drug reaction 13.59 10.18 12 49294 24008 29501213
Duodenal ulcer 13.58 10.18 40 49266 9198 29516023
Subileus 13.50 10.18 20 49286 2830 29522391
Pallor 13.48 10.18 70 49236 20954 29504267
Alopecia universalis 13.44 10.18 5 49301 72 29525149
Prothrombin time shortened 13.43 10.18 14 49292 1384 29523837
Cerebral haematoma 13.42 10.18 25 49281 4271 29520950
Urogenital haemorrhage 13.41 10.18 9 49297 481 29524740
Vascular stent thrombosis 13.36 10.18 19 49287 2591 29522630
Hypozincaemia 13.26 10.18 3 49303 5 29525216
Pseudarthrosis 13.25 10.18 5 49301 75 29525146
Cardiac valve sclerosis 13.25 10.18 5 49301 75 29525146
Product use issue 13.10 10.18 43 49263 51401 29473820
Stomal hernia 13.09 10.18 6 49300 150 29525071
Pain 13.09 10.18 204 49102 171228 29353993
Neurologic neglect syndrome 13.02 10.18 6 49300 152 29525069
Anaemia 12.95 10.18 432 48874 200519 29324702
Rhinalgia 12.92 10.18 8 49298 372 29524849
Respiratory distress 12.89 10.18 21 49285 32085 29493136
Periorbital discomfort 12.86 10.18 4 49302 32 29525189
Cranial sutures widening 12.79 10.18 5 49301 83 29525138
Oliguria 12.77 10.18 34 49272 7378 29517843
Mechanical urticaria 12.74 10.18 5 49301 84 29525137
Renal ischaemia 12.67 10.18 9 49297 528 29524693
Aortic valve disease mixed 12.63 10.18 5 49301 86 29525135
Renal-limited thrombotic microangiopathy 12.60 10.18 3 49303 7 29525214
Tumour marker increased 12.56 10.18 9 49297 535 29524686
Unresponsive to stimuli 12.55 10.18 14 49292 25112 29500109
Lip ulceration 12.40 10.18 10 49296 710 29524511
Hyperthyroidism 12.40 10.18 37 49269 8571 29516650
Orthostatic hypotension 12.27 10.18 72 49234 22557 29502664
Hypervolaemia 12.25 10.18 7 49299 17538 29507683
Renin increased 12.22 10.18 5 49301 94 29525127
Eosinophilic pneumonia 12.11 10.18 19 49287 2827 29522394
Brain stem infarction 12.10 10.18 12 49294 1118 29524103
Atrial fibrillation 12.04 10.18 245 49061 105401 29419820
Acute on chronic liver failure 11.94 10.18 5 49301 100 29525121
Coronary artery bypass 11.90 10.18 25 49281 4660 29520561
Infusion site thrombosis 11.89 10.18 5 49301 101 29525120
Conduction disorder 11.88 10.18 15 49291 1825 29523396
Hepatocellular carcinoma 11.84 10.18 32 49274 7006 29518215
Cholecystitis 11.83 10.18 38 49268 9159 29516062
Apnoeic attack 11.72 10.18 7 49299 305 29524916
Fracture 11.71 10.18 29 49277 6024 29519197
Laboratory test abnormal 11.66 10.18 8 49298 18177 29507044
Respiratory depression 11.63 10.18 4 49302 13519 29511702
Product quality issue 11.59 10.18 6 49300 15889 29509332
Hepatic function abnormal 11.56 10.18 108 49198 39151 29486070
Hepatitis acute 11.50 10.18 30 49276 6432 29518789
Wrong dose 11.50 10.18 8 49298 454 29524767
Thrombocytopenia 11.48 10.18 157 49149 134666 29390555
Aortic dilatation 11.43 10.18 11 49295 988 29524233
Atypical fibroxanthoma 11.40 10.18 6 49300 204 29525017
Cough 11.34 10.18 284 49022 126443 29398778
Gastrointestinal submucosal tumour 11.29 10.18 5 49301 115 29525106
Tongue haematoma 11.25 10.18 5 49301 116 29525105
Stoma complication 11.24 10.18 6 49300 210 29525011
Eczema 11.01 10.18 49 49257 13777 29511444
Tetany 10.99 10.18 9 49297 653 29524568
Urinary tract infection 10.99 10.18 73 49233 72281 29452940
Vasoplegia syndrome 10.88 10.18 13 49293 1495 29523726
Catheter site cellulitis 10.87 10.18 5 49301 126 29525095
Prostatomegaly 10.84 10.18 24 49282 4637 29520584
Candida infection 10.73 10.18 6 49300 15219 29510002
Nephritic syndrome 10.73 10.18 4 49302 58 29525163
Pancreatic disorder 10.64 10.18 13 49293 1530 29523691
Pyoderma gangrenosum 10.63 10.18 11 49295 1078 29524143
Albumin urine present 10.57 10.18 7 49299 366 29524855
Musculoskeletal stiffness 10.47 10.18 30 49276 37428 29487793
Feeling abnormal 10.38 10.18 51 49255 54394 29470827
B-cell lymphoma stage IV 10.37 10.18 4 49302 64 29525157
Blood parathyroid hormone increased 10.30 10.18 12 49294 1343 29523878
Aortic dissection 10.26 10.18 16 49290 2368 29522853
Aortic arteriosclerosis 10.21 10.18 21 49285 3855 29521366

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 482.35 10.11 1655 97951 447585 63951541
General physical health deterioration 355.02 10.11 895 98711 203530 64195596
Hyperkalaemia 309.54 10.11 558 99048 100571 64298555
Completed suicide 267.22 10.11 21 99585 224393 64174733
Hyponatraemia 196.01 10.11 588 99018 147751 64251375
Product monitoring error 176.00 10.11 108 99498 5346 64393780
Death 160.04 10.11 315 99291 482390 63916736
Haematochezia 156.27 10.11 328 99278 66045 64333081
Drug ineffective 149.90 10.11 729 98877 839518 63559608
Bradycardia 148.05 10.11 460 99146 117759 64281367
Product prescribing error 147.36 10.11 224 99382 35045 64364081
Angina pectoris 145.84 10.11 255 99351 44826 64354300
Product dose omission issue 142.72 10.11 61 99545 194686 64204440
Toxicity to various agents 129.41 10.11 227 99379 363286 64035840
Synovitis 127.70 10.11 6 99600 99084 64300042
Dizziness 113.49 10.11 1087 98519 429076 63970050
Renal impairment 112.01 10.11 459 99147 134558 64264568
Drug hypersensitivity 99.45 10.11 133 99473 237682 64161444
Drug abuse 92.97 10.11 44 99562 132330 64266796
Cough 89.95 10.11 784 98822 301364 64097762
Cardiac failure 88.53 10.11 422 99184 131951 64267175
Maternal exposure during pregnancy 84.21 10.11 22 99584 95862 64303264
Dyspnoea 78.92 10.11 1551 98055 717123 63682003
Lactic acidosis 76.85 10.11 239 99367 61171 64337955
Oligohydramnios 76.47 10.11 52 99554 3072 64396054
Hypotension 74 10.11 906 98700 380068 64019058
Arthropathy 73.68 10.11 48 99558 120919 64278207
Drug interaction 72.90 10.11 867 98739 361216 64037910
Blood creatinine increased 72.80 10.11 407 99199 135375 64263751
Pemphigus 71.29 10.11 6 99600 60695 64338431
Syncope 70.74 10.11 451 99155 157184 64241942
Fall 69.53 10.11 964 98642 415862 63983264
Blood pressure increased 69.19 10.11 480 99126 172072 64227054
Alopecia 66.88 10.11 95 99511 165595 64233531
Pain 66.82 10.11 541 99065 552970 63846156
Injection site pain 64.14 10.11 47 99559 111361 64287765
Off label use 63.98 10.11 647 98959 632159 63766967
Neovascularisation 63.57 10.11 32 99574 1071 64398055
Rubber sensitivity 63.44 10.11 34 99572 1298 64397828
Myalgia 61.10 10.11 437 99169 158180 64240946
Labelled drug-drug interaction medication error 60.22 10.11 116 99490 21946 64377180
Oedema peripheral 58.53 10.11 538 99068 209779 64189347
Neutropenia 58.37 10.11 183 99423 239441 64159685
Anaemia 56.85 10.11 860 98746 377820 64021306
Product use issue 56.40 10.11 92 99514 151623 64247503
Pemphigoid 54.97 10.11 83 99523 12903 64386223
Glossodynia 54.64 10.11 16 99590 64680 64334446
Sputum discoloured 51.35 10.11 96 99510 17760 64381366
Orthostatic hypotension 51.34 10.11 174 99432 46564 64352562
Hypertensive crisis 51.10 10.11 97 99509 18151 64380975
Cerebral infarction 49.74 10.11 158 99448 40886 64358240
Hypoglycaemia 48.52 10.11 270 99336 89622 64309504
Swelling 47.54 10.11 111 99495 160107 64239019
Sinusitis 45.83 10.11 98 99508 145830 64253296
Joint swelling 44.72 10.11 176 99430 215206 64183920
Arrhythmia 44.65 10.11 181 99425 52763 64346363
Therapeutic product effect decreased 43.75 10.11 69 99537 115282 64283844
Pericarditis 43.54 10.11 21 99585 62495 64336631
Arterial occlusive disease 43.48 10.11 54 99552 6979 64392147
Mental status changes 43.43 10.11 20 99586 61142 64337984
Atrial fibrillation 43.29 10.11 429 99177 170660 64228466
Renal artery stenosis 42.78 10.11 36 99570 2933 64396193
Presyncope 42.45 10.11 135 99471 34954 64364172
Infusion related reaction 41.89 10.11 123 99483 164344 64234782
Labile hypertension 41.43 10.11 19 99587 515 64398611
Blood cholesterol 41.43 10.11 17 99589 349 64398777
Blood pressure inadequately controlled 41.01 10.11 46 99560 5338 64393788
Systemic lupus erythematosus 40.59 10.11 36 99570 77576 64321550
Injection site erythema 40.57 10.11 30 99576 70770 64328356
Drug intolerance 40.06 10.11 152 99454 187840 64211286
Disease progression 39.79 10.11 101 99505 141579 64257547
Neurologic neglect syndrome 39.76 10.11 27 99579 1591 64397535
Hepatic enzyme increased 39.38 10.11 89 99517 129854 64269272
Interstitial lung disease 38.62 10.11 271 99335 97461 64301665
Electrolyte imbalance 38.04 10.11 105 99501 25138 64373988
Febrile neutropenia 37.90 10.11 155 99451 187502 64211624
Infection 37.78 10.11 152 99454 184728 64214398
Gamma-glutamyltransferase increased 37.13 10.11 161 99445 48349 64350777
Gastrointestinal angiodysplasia 36.71 10.11 21 99585 912 64398214
Vertigo 36.46 10.11 184 99422 58827 64340299
Jaundice 36.36 10.11 160 99446 48352 64350774
Rhabdomyolysis 35.46 10.11 253 99353 91473 64307653
Injection site reaction 35.14 10.11 14 99592 46650 64352476
Skin haemorrhage 35.10 10.11 54 99552 8531 64390595
Systemic infection 34.78 10.11 38 99568 4283 64394843
Cholestatic liver injury 34.32 10.11 35 99571 3644 64395482
Androgenetic alopecia 34.27 10.11 12 99594 156 64398970
Abdominal discomfort 34.12 10.11 155 99451 182167 64216959
Treatment failure 33.80 10.11 82 99524 116734 64282392
Hospitalisation 33.53 10.11 40 99566 75167 64323959
Therapy non-responder 32.77 10.11 32 99574 65867 64333259
Bronchopulmonary aspergillosis allergic 32.74 10.11 24 99582 1598 64397528
Hypersensitivity 32.18 10.11 175 99431 196277 64202849
Basilar artery occlusion 32.17 10.11 12 99594 189 64398937
Urinary hesitation 32.03 10.11 33 99573 3477 64395649
Palpitations 31.97 10.11 273 99333 104215 64294911
Intentional product misuse 31.65 10.11 39 99567 72256 64326870
Sepsis 31.57 10.11 217 99389 230124 64169002
Renal cyst haemorrhage 31.40 10.11 15 99591 447 64398679
Neuropathy peripheral 31.31 10.11 86 99520 117439 64281687
Rash 30.61 10.11 511 99095 458038 63941088
Diffuse alopecia 30.53 10.11 16 99590 583 64398543
Renal failure 30.51 10.11 421 99185 181267 64217859
Tubulointerstitial nephritis 30.43 10.11 111 99495 30798 64368328
Contraindicated product administered 30.17 10.11 77 99529 107752 64291374
Ventricular extrasystoles 29.54 10.11 76 99530 17453 64381673
Flatulence 29.33 10.11 121 99485 35545 64363581
Chromaturia 29.20 10.11 89 99517 22522 64376604
Drug resistance 29.06 10.11 9 99597 35093 64364033
Injection site bruising 28.92 10.11 10 99596 36363 64362763
Vasoplegia syndrome 28.91 10.11 28 99578 2739 64396387
C-reactive protein abnormal 28.90 10.11 5 99601 29042 64370084
Renal artery thrombosis 28.65 10.11 14 99592 439 64398687
Urogenital haemorrhage 28.63 10.11 16 99590 664 64398462
Hemiparesis 28.43 10.11 106 99500 29721 64369405
Blood creatine phosphokinase increased 28.40 10.11 171 99435 58387 64340739
Prothrombin time shortened 28.22 10.11 28 99578 2821 64396305
Fibromyalgia 28.11 10.11 10 99596 35721 64363405
Obstructive airways disorder 27.86 10.11 89 99517 23096 64376030
Hypomagnesaemia 27.80 10.11 123 99483 37253 64361873
Intraductal papillary mucinous neoplasm 27.76 10.11 15 99591 582 64398544
Haematoma 27.72 10.11 143 99463 46107 64353019
Circulatory collapse 27.39 10.11 114 99492 33618 64365508
Heart rate 27.25 10.11 8 99598 56 64399070
Peripheral arterial occlusive disease 27.25 10.11 43 99563 6944 64392182
Peripheral swelling 27.21 10.11 200 99406 208953 64190173
Vena cava injury 27.12 10.11 11 99595 219 64398907
Hyperuricaemia 27.10 10.11 53 99553 10138 64388988
Cardiac arrest 27.05 10.11 134 99472 153930 64245196
Gangrene 27.03 10.11 44 99562 7294 64391832
Multiple sclerosis relapse 26.89 10.11 15 99591 41120 64358006
Drug dependence 26.76 10.11 9 99597 33303 64365823
Seizure 26.60 10.11 150 99456 166742 64232384
Malaise 25.97 10.11 798 98808 395449 64003677
Sedation 25.85 10.11 16 99590 41446 64357680
Anuria 25.77 10.11 76 99530 18888 64380238
Hemiplegia 25.39 10.11 59 99547 12709 64386417
Sleep disorder due to general medical condition, insomnia type 25.11 10.11 5 99601 26265 64372861
Patient dissatisfaction with treatment 24.59 10.11 9 99597 134 64398992
Inappropriate antidiuretic hormone secretion 24.49 10.11 83 99523 22206 64376920
Carotid artery thrombosis 24.30 10.11 21 99585 1774 64397352
Retinal artery occlusion 24.19 10.11 26 99580 2877 64396249
Product quality issue 24.03 10.11 8 99598 29791 64369335
Forced expiratory volume decreased 23.71 10.11 40 99566 6827 64392299
Exposure during pregnancy 23.69 10.11 53 99553 77622 64321504
Aphasia 23.50 10.11 125 99481 40781 64358345
Musculoskeletal stiffness 23.49 10.11 104 99502 123102 64276024
Rheumatoid arthritis 23.39 10.11 153 99453 164141 64234985
Pancreatitis acute 23.30 10.11 129 99477 42726 64356400
Accidental exposure to product 23.23 10.11 6 99600 26358 64372768
Decreased appetite 23.04 10.11 583 99023 280706 64118420
SARS-CoV-2 antibody test positive 22.97 10.11 10 99596 239 64398887
Folliculitis 22.69 10.11 9 99597 30068 64369058
White blood cell count decreased 22.46 10.11 147 99459 157690 64241436
No adverse event 22.46 10.11 8 99598 28553 64370573
Lung hernia 22.40 10.11 7 99599 62 64399064
Vertigo positional 22.39 10.11 25 99581 2886 64396240
Acute cutaneous lupus erythematosus 22.33 10.11 11 99595 351 64398775
Helicobacter infection 22.31 10.11 16 99590 38346 64360780
Renal artery angioplasty 21.90 10.11 5 99601 10 64399116
Myelosuppression 21.83 10.11 5 99601 23825 64375301
Hepatic function abnormal 21.80 10.11 172 99434 64141 64334985
Barotrauma 21.75 10.11 9 99597 189 64398937
Hypoxia 21.66 10.11 67 99539 88082 64311044
Gastrointestinal disorder 21.47 10.11 69 99537 89640 64309486
Cerebral haematoma 21.12 10.11 39 99567 7146 64391980
Neurotoxicity 21 10.11 8 99598 27396 64371730
Disorientation 21.00 10.11 153 99453 55675 64343451
Duodenal ulcer 20.72 10.11 59 99547 14376 64384750
Total cholesterol/HDL ratio increased 20.64 10.11 9 99597 216 64398910
Aortic dissection 20.53 10.11 26 99580 3426 64395700
Psoriatic arthropathy 20.40 10.11 22 99584 43259 64355867
Haematoma muscle 20.36 10.11 19 99587 1774 64397352
Melaena 20.28 10.11 147 99459 53401 64345725
Device issue 20.25 10.11 5 99601 22643 64376483
Atrioventricular block second degree 20.20 10.11 36 99570 6418 64392708
Haematuria 20.10 10.11 161 99445 60310 64338816
Spinal osteoarthritis 19.99 10.11 58 99548 14283 64384843
Intraventricular haemorrhage 19.68 10.11 28 99578 4125 64395001
Abdominal pain lower 19.60 10.11 87 99519 26382 64372744
Dyspnoea at rest 19.42 10.11 35 99571 6294 64392832
Poisoning 19.24 10.11 5 99601 21874 64377252
Sensitivity to weather change 19.18 10.11 36 99570 6678 64392448
Non-cardiogenic pulmonary oedema 19.13 10.11 16 99590 1292 64397834
Glomerular filtration rate decreased 19.02 10.11 70 99536 19502 64379624
Paradoxical drug reaction 18.98 10.11 34 99572 6086 64393040
Respiratory tract inflammation 18.98 10.11 13 99593 777 64398349
Intentional overdose 18.96 10.11 73 99533 89871 64309255
Skull fracture 18.81 10.11 17 99589 1524 64397602
Blood hyposmosis 18.80 10.11 5 99601 23 64399103
Purpura senile 18.77 10.11 11 99595 500 64398626
Pneumobilia 18.66 10.11 8 99598 184 64398942
Faeces discoloured 18.63 10.11 84 99522 25645 64373481
Altered state of consciousness 18.58 10.11 111 99495 37791 64361335
Cytomegalovirus infection 18.57 10.11 18 99588 37181 64361945
Blood pressure measurement 18.56 10.11 10 99596 386 64398740
Gastrointestinal ischaemia 18.49 10.11 10 99596 389 64398737
Polyuria 18.47 10.11 52 99554 12591 64386535
Multiple drug therapy 18.45 10.11 20 99586 2234 64396892
Injection site swelling 18.43 10.11 22 99584 41331 64357795
Unevaluable event 18.39 10.11 31 99575 50458 64348668
Haematemesis 18.37 10.11 130 99476 46869 64352257
Full blood count decreased 18.32 10.11 6 99600 22576 64376550
Oral lichen planus 18.27 10.11 12 99594 669 64398457
Anxiety disorder due to a general medical condition 18.24 10.11 4 99602 6 64399120
Cerebral haemorrhage 18.07 10.11 138 99468 50952 64348174
Pallor 18.02 10.11 112 99494 38669 64360457
Hepatocellular carcinoma 18.01 10.11 40 99566 8363 64390763
Renal artery stent placement 17.98 10.11 5 99601 28 64399098
Actinic keratosis 17.72 10.11 30 99576 5135 64393991
Respiratory depression 17.71 10.11 7 99599 23436 64375690
Hypochromic anaemia 17.64 10.11 20 99586 2348 64396778
Device malfunction 17.62 10.11 3 99603 17630 64381496
Irritable bowel syndrome 17.61 10.11 19 99587 37350 64361776
Clostridium difficile infection 17.47 10.11 18 99588 36145 64362981
Discomfort 17.47 10.11 65 99541 80813 64318313
Acute myocardial infarction 17.21 10.11 174 99432 69544 64329582
Glycosylated haemoglobin increased 17.03 10.11 59 99547 15960 64383166
Premature delivery 16.83 10.11 4 99602 18585 64380541
Pain in jaw 16.79 10.11 23 99583 40732 64358394
Hepatitis acute 16.64 10.11 52 99554 13337 64385789
Supine hypertension 16.59 10.11 9 99597 352 64398774
Therapeutic product effect incomplete 16.48 10.11 93 99513 103389 64295737
Hypozincaemia 16.45 10.11 5 99601 40 64399086
Therapeutic response decreased 16.41 10.11 35 99571 52153 64346973
Mental status changes postoperative 16.41 10.11 7 99599 159 64398967
Hypertension 16.39 10.11 520 99086 258741 64140385
Paresis cranial nerve 16.34 10.11 5 99601 41 64399085
Renovascular hypertension 16.34 10.11 5 99601 41 64399085
Productive cough 16.33 10.11 179 99427 73024 64326102
Wrong strength 16.33 10.11 7 99599 161 64398965
Tarsal tunnel syndrome 16.29 10.11 10 99596 495 64398631
Respiratory arrest 16.28 10.11 36 99570 52949 64346177
Carotid arteriosclerosis 16.24 10.11 18 99588 2061 64397065
Coronavirus infection 16.24 10.11 30 99576 5500 64393626
Lichen planus 16.23 10.11 19 99587 2309 64396817
Occult blood 16.20 10.11 15 99591 1387 64397739
Basal ganglia haemorrhage 16.16 10.11 15 99591 1391 64397735
Hemiataxia 16.13 10.11 5 99601 43 64399083
Confusional state 16.04 10.11 522 99084 260622 64138504
Adrenal insufficiency 15.97 10.11 73 99533 22414 64376712
Cornea verticillata 15.88 10.11 6 99600 98 64399028
Internal haemorrhage 15.88 10.11 36 99570 7631 64391495
Bronchiectasis 15.84 10.11 53 99553 14087 64385039
Dyschezia 15.70 10.11 19 99587 2391 64396735
Disturbance in attention 15.69 10.11 113 99493 40961 64358165
Unresponsive to stimuli 15.68 10.11 34 99572 50359 64348767
Idiopathic pulmonary fibrosis 15.67 10.11 24 99582 3776 64395350
Blister 15.64 10.11 68 99538 80899 64318227
Muscular weakness 15.63 10.11 280 99326 127058 64272068
Tetany 15.60 10.11 18 99588 2154 64396972
Mesenteric artery thrombosis 15.59 10.11 10 99596 535 64398591
Treatment noncompliance 15.56 10.11 27 99579 43455 64355671
Vertebral artery stenosis 15.53 10.11 7 99599 182 64398944
Wrong technique in product usage process 15.53 10.11 50 99556 64924 64334202
Fungal infection 15.50 10.11 18 99588 34233 64364893
Sinonasal obstruction 15.39 10.11 7 99599 186 64398940
Total lung capacity decreased 15.37 10.11 16 99590 1706 64397420
Aortic arteriosclerosis 15.37 10.11 35 99571 7441 64391685
Diarrhoea 15.34 10.11 1305 98301 721399 63677727
Asthma 15.30 10.11 219 99387 95006 64304120
Psoas abscess 15.22 10.11 12 99594 891 64398235
Abdominal wall haemorrhage 15.22 10.11 9 99597 416 64398710
Coronary artery stenosis 15.21 10.11 45 99561 11203 64387923
International normalised ratio increased 15.18 10.11 188 99418 78979 64320147
Vasculitic rash 15.15 10.11 17 99589 1974 64397152
Cardiac failure chronic 15.03 10.11 39 99567 9002 64390124
Confusion postoperative 14.96 10.11 7 99599 199 64398927
Injection site pruritus 14.94 10.11 22 99584 37804 64361322
Tinnitus 14.88 10.11 97 99509 34036 64365090
Renal function test abnormal 14.87 10.11 24 99582 3950 64395176
Small intestinal obstruction 14.83 10.11 9 99597 23564 64375562
Sinus rhythm 14.82 10.11 10 99596 583 64398543
Acute abdomen 14.82 10.11 20 99586 2804 64396322
Spider naevus 14.81 10.11 6 99600 119 64399007
Proteinuria 14.77 10.11 83 99523 27640 64371486
Costovertebral angle tenderness 14.61 10.11 7 99599 210 64398916
Tenderness 14.56 10.11 6 99600 19596 64379530
Cytokine release syndrome 14.50 10.11 7 99599 20822 64378304
Bradyarrhythmia 14.48 10.11 23 99583 3735 64395391
Nocturia 14.47 10.11 44 99562 11121 64388005
Deep vein thrombosis 14.43 10.11 99 99507 105083 64294043
Device lead damage 14.35 10.11 3 99603 3 64399123
Wound 14.30 10.11 65 99541 76412 64322714
Mobility decreased 14.30 10.11 76 99530 85764 64313362
Urticaria 14.23 10.11 152 99454 147165 64251961
Cystitis escherichia 14.19 10.11 9 99597 472 64398654
Impaired healing 14.13 10.11 47 99559 60426 64338700
Joint injury 14.11 10.11 9 99597 22938 64376188
Product use in unapproved indication 14.09 10.11 190 99416 176428 64222698
Iron deficiency 14.09 10.11 33 99573 7144 64391982
Prostatomegaly 14.06 10.11 20 99586 2947 64396179
Aortic valve incompetence 13.99 10.11 36 99570 8265 64390861
Vestibular migraine 13.91 10.11 6 99600 140 64398986
Hypocalcaemia 13.78 10.11 111 99495 41642 64357484
Adjustment disorder 13.74 10.11 19 99587 2726 64396400
Haemophagocytic lymphohistiocytosis 13.73 10.11 5 99601 17604 64381522
Urinary retention 13.72 10.11 126 99480 49075 64350051
Adverse event 13.70 10.11 25 99581 39464 64359662
Shock hypoglycaemic 13.67 10.11 7 99599 243 64398883
Cold sweat 13.66 10.11 56 99550 16399 64382727
Rales 13.59 10.11 53 99553 15176 64383950
pH body fluid increased 13.57 10.11 5 99601 76 64399050
Staphylococcal infection 13.55 10.11 37 99569 50641 64348485
Knee arthroplasty 13.55 10.11 13 99593 26986 64372140
Urinary tract infection 13.54 10.11 264 99342 231332 64167794
Dehydration 13.49 10.11 434 99172 216329 64182797
Musculoskeletal pain 13.48 10.11 188 99418 81106 64318020
Ill-defined disorder 13.48 10.11 30 99576 44022 64355104
Metabolic acidosis 13.38 10.11 168 99438 70790 64328336
Respiratory failure 13.37 10.11 172 99434 161011 64238115
Food aversion 13.35 10.11 10 99596 688 64398438
Ear infection 13.30 10.11 10 99596 23394 64375732
Mucosal haemorrhage 13.28 10.11 17 99589 2264 64396862
Choroidal detachment 13.21 10.11 9 99597 533 64398593
Necrotising myositis 13.21 10.11 11 99595 883 64398243
Kussmaul respiration 13.16 10.11 8 99598 389 64398737
Skin texture abnormal 13.16 10.11 8 99598 389 64398737
Periorbital discomfort 13.16 10.11 4 99602 32 64399094
Desmoplastic melanoma 13.16 10.11 4 99602 32 64399094
Gerstmann's syndrome 13.14 10.11 3 99603 6 64399120
Macular ischaemia 13.05 10.11 5 99601 85 64399041
Brain stem infarction 12.91 10.11 15 99591 1808 64397318
Arthralgia 12.90 10.11 555 99051 441705 63957421
Asthenia 12.83 10.11 795 98811 427249 63971877
Tonsillar ulcer 12.77 10.11 8 99598 411 64398715
Sputum retention 12.76 10.11 11 99595 926 64398200
Diabetic nephropathy 12.74 10.11 18 99588 2636 64396490
Therapy cessation 12.73 10.11 19 99587 32470 64366656
Joint range of motion decreased 12.72 10.11 7 99599 19336 64379790
Pancreatic disorder 12.67 10.11 19 99587 2935 64396191
Anti-erythropoietin antibody negative 12.63 10.11 7 99599 286 64398840
Palmar-plantar erythrodysaesthesia syndrome 12.62 10.11 82 99524 28737 64370389
Alopecia universalis 12.58 10.11 6 99600 178 64398948
Histamine intolerance 12.55 10.11 4 99602 38 64399088
Exercise tolerance decreased 12.55 10.11 33 99573 7677 64391449
Subarachnoid haemorrhage 12.46 10.11 59 99547 18379 64380747
Cardiac murmur functional 12.46 10.11 4 99602 39 64399087
Metastases to fallopian tube 12.37 10.11 4 99602 40 64399086
Flushing 12.35 10.11 71 99535 78577 64320549
Ischaemic stroke 12.34 10.11 82 99524 28953 64370173
Adverse drug reaction 12.30 10.11 33 99573 45431 64353695
Acute right ventricular failure 12.26 10.11 7 99599 303 64398823
Complication associated with device 12.24 10.11 4 99602 15076 64384050
Encephalopathy 12.23 10.11 48 99558 58771 64340355
Depression suicidal 12.19 10.11 17 99589 2458 64396668
Xanthopsia 12.19 10.11 7 99599 306 64398820
Hyperthyroidism 12.16 10.11 58 99548 18121 64381005
Loss of personal independence in daily activities 12.15 10.11 64 99542 72390 64326736
Eczema nummular 12.13 10.11 7 99599 309 64398817
Supraventricular tachyarrhythmia 12.13 10.11 5 99601 104 64399022
Therapy interrupted 12.12 10.11 8 99598 20028 64379098
Irritability 12.10 10.11 24 99582 36722 64362404
Eczema 12.08 10.11 83 99523 29637 64369489
Lower respiratory tract infection 12.04 10.11 91 99515 94523 64304603
Haemorrhage subcutaneous 11.99 10.11 23 99583 4338 64394788
Depression 11.95 10.11 205 99401 183086 64216040
Fracture 11.95 10.11 59 99547 18696 64380430
Atypical fibroxanthoma 11.94 10.11 6 99600 200 64398926
Atrioventricular block complete 11.92 10.11 49 99557 14369 64384757
Cardio-respiratory arrest 11.88 10.11 96 99510 98297 64300829
Pulmonary fibrosis 11.88 10.11 83 99523 29795 64369331
Leiomyoma 11.85 10.11 7 99599 323 64398803
Injection site haemorrhage 11.83 10.11 12 99594 24266 64374860
Toxic skin eruption 11.82 10.11 60 99546 19224 64379902
Product storage error 11.79 10.11 3 99603 13315 64385811
Breast discomfort 11.79 10.11 7 99599 326 64398800
Gastroenteritis viral 11.77 10.11 8 99598 19721 64379405
Pregnancy 11.75 10.11 9 99597 20856 64378270
Coronary artery bypass 11.70 10.11 27 99579 5788 64393338
Wheezing 11.65 10.11 182 99424 80397 64318729
Laboratory test abnormal 11.60 10.11 12 99594 24051 64375075
Nasal congestion 11.58 10.11 50 99556 59608 64339518
Muscle rupture 11.53 10.11 19 99587 3181 64395945
Renin increased 11.47 10.11 6 99600 218 64398908
Visual acuity reduced transiently 11.44 10.11 6 99600 219 64398907
Cardiovascular insufficiency 11.43 10.11 17 99589 2607 64396519
Drug metabolising enzyme decreased 11.42 10.11 3 99603 13 64399113
Dermatosis 11.39 10.11 8 99598 498 64398628
Blood uric acid increased 11.37 10.11 33 99573 8130 64390996
Drug dose titration not performed 11.35 10.11 9 99597 674 64398452
Transaminases increased 11.34 10.11 112 99494 44482 64354644
Diverticulum intestinal 11.31 10.11 31 99575 7389 64391737
Duodenal ulcer haemorrhage 11.26 10.11 28 99578 6297 64392829
Transient ischaemic attack 11.26 10.11 111 99495 44071 64355055
Lip infection 11.24 10.11 5 99601 126 64399000
COVID-19 11.23 10.11 57 99549 65083 64334043
Eosinophilic pneumonia 11.21 10.11 23 99583 4554 64394572
Aortic valve stenosis 11.20 10.11 23 99583 4557 64394569
Lichen sclerosus 11.15 10.11 10 99596 887 64398239
Chest wall mass 11.10 10.11 5 99601 130 64398996
Ophthalmoplegia 11.05 10.11 17 99589 2685 64396441
Abdominal pain 11.05 10.11 589 99017 311786 64087340
Musculoskeletal disorder 11.04 10.11 7 99599 17899 64381227
Psychotic disorder 11.03 10.11 23 99583 34555 64364571
Pharyngeal enanthema 11.03 10.11 4 99602 58 64399068
Nephrogenic anaemia 11.00 10.11 19 99587 3306 64395820
Drug ineffective for unapproved indication 10.96 10.11 84 99522 31049 64368077
Atrioventricular block first degree 10.95 10.11 39 99567 10695 64388431
Gastroenteritis 10.93 10.11 81 99525 29630 64369496
Disease recurrence 10.88 10.11 20 99586 31490 64367636
Anaemia folate deficiency 10.85 10.11 6 99600 244 64398882
Post concussion syndrome 10.83 10.11 8 99598 539 64398587
Injury 10.82 10.11 47 99559 55945 64343181
Aortic dilatation 10.71 10.11 12 99594 1391 64397735
Bundle branch block left 10.70 10.11 37 99569 9997 64389129
Immune reconstitution inflammatory syndrome 10.68 10.11 3 99603 12467 64386659
Gallbladder cancer 10.66 10.11 7 99599 390 64398736
Intentional product use issue 10.64 10.11 95 99511 95269 64303857
Plasma cell myeloma 10.63 10.11 36 99570 46039 64353087
B-cell lymphoma stage IV 10.61 10.11 4 99602 65 64399061
Hepatitis cholestatic 10.60 10.11 42 99564 12113 64387013
Eczema eyelids 10.59 10.11 5 99601 145 64398981
Pericarditis constrictive 10.56 10.11 8 99598 560 64398566
Bronchial hyperreactivity 10.55 10.11 16 99590 2496 64396630
Abortion spontaneous 10.55 10.11 14 99592 25129 64373997
Abdominal pain upper 10.51 10.11 349 99257 174681 64224445
Renal-limited thrombotic microangiopathy 10.48 10.11 3 99603 19 64399107
Retroperitoneal fibrosis 10.47 10.11 8 99598 567 64398559
Neutrophil count decreased 10.42 10.11 73 99533 77123 64322003
Neuroleptic malignant syndrome 10.41 10.11 14 99592 24982 64374144
Aplasia pure red cell 10.39 10.11 29 99577 6985 64392141
Lung perforation 10.39 10.11 4 99602 69 64399057
Therapeutic drug monitoring analysis not performed 10.35 10.11 11 99595 1201 64397925
Vascular compression 10.29 10.11 6 99600 270 64398856
Congenital anomaly in offspring 10.28 10.11 4 99602 71 64399055
Malignant neoplasm of pleura 10.28 10.11 5 99601 155 64398971
Upper gastrointestinal haemorrhage 10.23 10.11 91 99515 35129 64363997
Uterine dilation and evacuation 10.22 10.11 3 99603 21 64399105
Oversensing 10.22 10.11 3 99603 21 64399105
Anastomotic infection 10.22 10.11 3 99603 21 64399105
Lung opacity 10.21 10.11 18 99588 3181 64395945
Female reproductive tract disorder 10.21 10.11 6 99600 274 64398852
Hypervolaemia 10.20 10.11 28 99578 38257 64360869
Brain stem stroke 10.20 10.11 7 99599 420 64398706
Basal cell carcinoma 10.19 10.11 82 99524 30756 64368370
Chronic obstructive pulmonary disease 10.18 10.11 66 99540 70982 64328144
Flail chest 10.18 10.11 4 99602 73 64399053
Paresis 10.17 10.11 19 99587 3513 64395613
Neoplasm progression 10.16 10.11 31 99575 40933 64358193
Haemorrhagic cyst 10.15 10.11 6 99600 277 64398849
Osteochondrosis 10.14 10.11 12 99594 1475 64397651
Prerenal failure 10.12 10.11 18 99588 3204 64395922

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09CA06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
Angiotensin II receptor blockers (ARBs), plain
ATC C09DA06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and diuretics
ATC C09DB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
FDA MoA N0000000070 Angiotensin 2 Receptor Antagonists
FDA EPC N0000175561 Angiotensin 2 Receptor Blocker
MeSH PA D047228 Angiotensin II Type 1 Receptor Blockers
MeSH PA D057911 Angiotensin Receptor Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Atrial fibrillation off-label use 49436004 DOID:0060224
Diabetic renal disease off-label use 127013003
Diastolic heart failure off-label use 418304008 DOID:9775
Nondiabetic Proteinuric Nephropathy off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Oliguria contraindication 83128009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Surgical procedure contraindication 387713003
Azotemia contraindication 445009001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.25 acidic
pKa2 3.2 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Type-1 angiotensin II receptor GPCR ANTAGONIST IC50 9.16 CHEMBL CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.52 CHEMBL
Alpha-2B adrenergic receptor GPCR Ki 5.76 CHEMBL
Beta-3 adrenergic receptor GPCR Ki 5.49 CHEMBL
Adenosine receptor A3 GPCR Ki 6.16 CHEMBL
Cytochrome P450 2C9 Enzyme IC50 5.52 CHEMBL
Epidermal growth factor receptor Kinase IC50 5.48 CHEMBL
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor EC50 5.38 CHEMBL
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.23 CHEMBL
Thromboxane-A synthase Enzyme IC50 5.51 CHEMBL
DNA polymerase kappa Enzyme IC50 5.25 CHEMBL
DNA polymerase iota Enzyme IC50 5.21 CHEMBL
DNA polymerase eta Enzyme IC50 4.95 CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.05 CHEMBL
NEDD8-activating enzyme E1 regulatory subunit Enzyme IC50 4.78 CHEMBL
Type-1 angiotensin II receptor GPCR IC50 6.96 CHEMBL
Cruzipain Enzyme IC50 4.38 CHEMBL
Type-1 angiotensin II receptor GPCR Ki 9.19 CHEMBL

External reference:

IDSource
4021148 VUID
N0000179517 NUI
D00522 KEGG_DRUG
135481 RXNORM
C0527379 UMLSCUI
CHEBI:3348 CHEBI
CHEBI:149509 CHEBI
CHEMBL1014 ChEMBL_ID
DB00796 DRUGBANK_ID
C077793 MESH_SUPPLEMENTAL_RECORD_UI
8352 IUPHAR_LIGAND_ID
C081643 MESH_SUPPLEMENTAL_RECORD_UI
587 IUPHAR_LIGAND_ID
139481-59-7 SECONDARY_CAS_RN
R85M2X0D68 UNII
2540 PUBCHEM_CID
2541 PUBCHEM_CID
DB13919 DRUGBANK_ID
188909 MMSL
7490 MMSL
d04322 MMSL
007275 NDDF
007276 NDDF
108587008 SNOMEDCT_US
372512008 SNOMEDCT_US
386878000 SNOMEDCT_US
4021148 VANDF
4021151 VANDF
C0717550 UMLSCUI
CHEMBL1016 ChEMBL_ID
7239 INN_ID
S8Q36MD2XX UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Candesartan Cilexetil and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-3001 TABLET 16 mg ORAL ANDA 21 sections
Candesartan Cilexetil and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-3002 TABLET 32 mg ORAL ANDA 21 sections
Candesartan Cilexetil and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-3003 TABLET 32 mg ORAL ANDA 21 sections
candesartan cilexetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-3224 TABLET 4 mg ORAL ANDA 27 sections
candesartan cilexetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-3225 TABLET 8 mg ORAL ANDA 27 sections
candesartan cilexetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-3231 TABLET 16 mg ORAL ANDA 27 sections
candesartan cilexetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-3232 TABLET 32 mg ORAL ANDA 27 sections
Candesartan HUMAN PRESCRIPTION DRUG LABEL 1 0904-7034 TABLET 32 mg ORAL ANDA 28 sections
Candesartan Human Prescription Drug Label 1 33342-114 TABLET 4 mg ORAL ANDA 28 sections
Candesartan Human Prescription Drug Label 1 33342-115 TABLET 8 mg ORAL ANDA 28 sections
Candesartan Human Prescription Drug Label 1 33342-116 TABLET 16 mg ORAL ANDA 28 sections
Candesartan Human Prescription Drug Label 1 33342-117 TABLET 32 mg ORAL ANDA 28 sections
Candesartan Cilexetil and Hydrochlorothiazide Human Prescription Drug Label 2 33342-131 TABLET 16 mg ORAL ANDA 19 sections
Candesartan Cilexetil and Hydrochlorothiazide Human Prescription Drug Label 2 33342-132 TABLET 32 mg ORAL ANDA 19 sections
Candesartan Cilexetil and Hydrochlorothiazide Human Prescription Drug Label 2 33342-133 TABLET 32 mg ORAL ANDA 19 sections
candesartan cilexetil and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 43547-459 TABLET 16 mg ORAL ANDA 22 sections
candesartan cilexetil and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 43547-460 TABLET 32 mg ORAL ANDA 22 sections
candesartan cilexetil and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 43547-461 TABLET 32 mg ORAL ANDA 22 sections
CANDESARTAN CILEXETIL Human Prescription Drug Label 1 46708-060 TABLET 32 mg ORAL ANDA 27 sections
CANDESARTAN CILEXETIL Human Prescription Drug Label 1 46708-341 TABLET 4 mg ORAL ANDA 28 sections
CANDESARTAN CILEXETIL Human Prescription Drug Label 1 46708-342 TABLET 8 mg ORAL ANDA 28 sections
CANDESARTAN CILEXETIL Human Prescription Drug Label 1 46708-343 TABLET 16 mg ORAL ANDA 28 sections
Candesartan cilexetil HUMAN PRESCRIPTION DRUG LABEL 1 49884-658 TABLET 4 mg ORAL NDA authorized generic 27 sections
Candesartan cilexetil HUMAN PRESCRIPTION DRUG LABEL 1 49884-659 TABLET 8 mg ORAL NDA authorized generic 27 sections
Candesartan cilexetil HUMAN PRESCRIPTION DRUG LABEL 1 49884-660 TABLET 16 mg ORAL NDA authorized generic 27 sections
Candesartan cilexetil HUMAN PRESCRIPTION DRUG LABEL 1 49884-661 TABLET 32 mg ORAL NDA authorized generic 27 sections
ATACAND HUMAN PRESCRIPTION DRUG LABEL 1 54868-4413 TABLET 16 mg ORAL NDA 27 sections
ATACAND HUMAN PRESCRIPTION DRUG LABEL 1 54868-4612 TABLET 32 mg ORAL NDA 27 sections
ATACAND HCT HUMAN PRESCRIPTION DRUG LABEL 2 54868-4729 TABLET 16 mg ORAL NDA 22 sections
ATACAND HCT HUMAN PRESCRIPTION DRUG LABEL 2 54868-4869 TABLET 32 mg ORAL NDA 22 sections