Stem definition | Drug id | CAS RN |
---|---|---|
angiotensin II receptor antagonists, antihypertensive (non-peptidic) | 475 | 145040-37-5 |
Dose | Unit | Route |
---|---|---|
8 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.05 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.61 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
June 4, 1998 | FDA | ASTRAZENECA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 385.57 | 10.18 | 888 | 57803 | 234967 | 46392404 |
Hyponatraemia | 354.36 | 10.18 | 530 | 58161 | 100802 | 46526569 |
Hyperkalaemia | 163.96 | 10.18 | 256 | 58435 | 50453 | 46576918 |
Drug ineffective | 148.35 | 10.18 | 404 | 58287 | 677434 | 45949937 |
General physical health deterioration | 140.48 | 10.18 | 390 | 58301 | 115379 | 46511992 |
Oligohydramnios | 123.30 | 10.18 | 80 | 58611 | 5385 | 46621986 |
Completed suicide | 121.59 | 10.18 | 19 | 58672 | 145901 | 46481470 |
Product dose omission issue | 119.65 | 10.18 | 32 | 58659 | 168488 | 46458883 |
Death | 98.79 | 10.18 | 169 | 58522 | 335379 | 46291992 |
Drug interaction | 98.05 | 10.18 | 509 | 58182 | 202585 | 46424786 |
Drug hypersensitivity | 97.14 | 10.18 | 98 | 58593 | 243727 | 46383644 |
Bradycardia | 95.28 | 10.18 | 238 | 58453 | 66060 | 46561311 |
Angina pectoris | 93.30 | 10.18 | 140 | 58551 | 26635 | 46600736 |
Lactic acidosis | 90.43 | 10.18 | 157 | 58534 | 33752 | 46593619 |
Cardiac failure | 86.89 | 10.18 | 259 | 58432 | 79689 | 46547682 |
Pain | 81.24 | 10.18 | 317 | 58374 | 476631 | 46150740 |
Syncope | 80.51 | 10.18 | 302 | 58389 | 104501 | 46522870 |
Orthostatic hypotension | 78.98 | 10.18 | 124 | 58567 | 24534 | 46602837 |
Blood pressure increased | 75.15 | 10.18 | 337 | 58354 | 126329 | 46501042 |
Hypotension | 75.14 | 10.18 | 525 | 58166 | 232064 | 46395307 |
Inappropriate antidiuretic hormone secretion | 73.99 | 10.18 | 90 | 58601 | 14012 | 46613359 |
Dizziness | 69.11 | 10.18 | 692 | 57999 | 339722 | 46287649 |
Hypertensive crisis | 68.38 | 10.18 | 85 | 58606 | 13530 | 46613841 |
Injection site pain | 67.70 | 10.18 | 25 | 58666 | 107127 | 46520244 |
Blood creatinine increased | 66.17 | 10.18 | 229 | 58462 | 76174 | 46551197 |
Rheumatoid arthritis | 60.99 | 10.18 | 132 | 58559 | 240083 | 46387288 |
Renal impairment | 60.18 | 10.18 | 218 | 58473 | 74154 | 46553217 |
Fall | 55.60 | 10.18 | 645 | 58046 | 328452 | 46298919 |
Synovitis | 55.53 | 10.18 | 6 | 58685 | 61069 | 46566302 |
Arterial occlusive disease | 55.49 | 10.18 | 47 | 58644 | 4757 | 46622614 |
Hypertension | 53.03 | 10.18 | 425 | 58266 | 195931 | 46431440 |
Maternal exposure during pregnancy | 52.41 | 10.18 | 32 | 58659 | 102517 | 46524854 |
Hypoglycaemia | 49.77 | 10.18 | 166 | 58525 | 54183 | 46573188 |
Labile hypertension | 49.53 | 10.18 | 20 | 58671 | 488 | 46626883 |
Disorientation | 49.34 | 10.18 | 129 | 58562 | 36789 | 46590582 |
Haematochezia | 48.07 | 10.18 | 129 | 58562 | 37364 | 46590007 |
Circulatory collapse | 43.77 | 10.18 | 89 | 58602 | 21535 | 46605836 |
Sputum discoloured | 43.35 | 10.18 | 66 | 58625 | 12712 | 46614659 |
Confusional state | 42.56 | 10.18 | 345 | 58346 | 159547 | 46467824 |
Alopecia | 42.23 | 10.18 | 88 | 58603 | 162326 | 46465045 |
Vertigo | 41.61 | 10.18 | 152 | 58539 | 51896 | 46575475 |
Rubber sensitivity | 41.16 | 10.18 | 26 | 58665 | 1670 | 46625701 |
Product use issue | 40.00 | 10.18 | 36 | 58655 | 94608 | 46532763 |
Injection site erythema | 39.76 | 10.18 | 22 | 58669 | 74405 | 46552966 |
Cough | 39.13 | 10.18 | 452 | 58239 | 229797 | 46397574 |
Basilar artery occlusion | 38.93 | 10.18 | 12 | 58679 | 127 | 46627244 |
Atrial fibrillation | 37.67 | 10.18 | 241 | 58450 | 103349 | 46524022 |
Gamma-glutamyltransferase increased | 37.50 | 10.18 | 106 | 58585 | 31634 | 46595737 |
Rhabdomyolysis | 37.47 | 10.18 | 127 | 58564 | 41782 | 46585589 |
Swelling | 37.19 | 10.18 | 62 | 58629 | 124449 | 46502922 |
Cerebral infarction | 36.87 | 10.18 | 87 | 58604 | 23279 | 46604092 |
Androgenetic alopecia | 36.14 | 10.18 | 12 | 58679 | 164 | 46627207 |
Arthropathy | 36.06 | 10.18 | 32 | 58659 | 84668 | 46542703 |
Pemphigoid | 36.01 | 10.18 | 40 | 58651 | 5651 | 46621720 |
Altered state of consciousness | 34.76 | 10.18 | 85 | 58606 | 23263 | 46604108 |
Diffuse alopecia | 34.68 | 10.18 | 16 | 58675 | 544 | 46626827 |
Anaemia | 34.07 | 10.18 | 480 | 58211 | 255299 | 46372072 |
Psychomotor retardation | 34.04 | 10.18 | 30 | 58661 | 3203 | 46624168 |
Lung opacity | 33.45 | 10.18 | 20 | 58671 | 1164 | 46626207 |
Gangrene | 33.21 | 10.18 | 35 | 58656 | 4660 | 46622711 |
Hand deformity | 32.46 | 10.18 | 3 | 58688 | 34571 | 46592800 |
Vasoplegia syndrome | 32.30 | 10.18 | 19 | 58672 | 1073 | 46626298 |
Renal failure | 31.78 | 10.18 | 248 | 58443 | 113346 | 46514025 |
Non-cardiogenic pulmonary oedema | 31.49 | 10.18 | 15 | 58676 | 549 | 46626822 |
Occupational asthma | 30.79 | 10.18 | 10 | 58681 | 127 | 46627244 |
Anuria | 30.56 | 10.18 | 53 | 58638 | 11378 | 46615993 |
Glossodynia | 30.38 | 10.18 | 9 | 58682 | 44364 | 46583007 |
Forced expiratory volume decreased | 29.12 | 10.18 | 34 | 58657 | 5070 | 46622301 |
Product prescribing error | 28.80 | 10.18 | 72 | 58619 | 19975 | 46607396 |
Off label use | 28.05 | 10.18 | 324 | 58367 | 379517 | 46247854 |
Drug intolerance | 28.04 | 10.18 | 93 | 58598 | 146956 | 46480415 |
Toxicity to various agents | 28.03 | 10.18 | 154 | 58537 | 211612 | 46415759 |
Lichen planus | 27.71 | 10.18 | 21 | 58670 | 1812 | 46625559 |
Therapeutic product effect incomplete | 27.16 | 10.18 | 35 | 58656 | 78118 | 46549253 |
Haematoma muscle | 27.05 | 10.18 | 14 | 58677 | 614 | 46626757 |
Sinusitis | 26.91 | 10.18 | 79 | 58612 | 129689 | 46497682 |
Osteochondrosis | 26.41 | 10.18 | 16 | 58675 | 954 | 46626417 |
Hospitalisation | 25.73 | 10.18 | 25 | 58666 | 63360 | 46564011 |
Fibromyalgia | 25.70 | 10.18 | 7 | 58684 | 36456 | 46590915 |
Oesophageal dilatation | 25.16 | 10.18 | 11 | 58680 | 329 | 46627042 |
Gastrointestinal tract adenoma | 25.16 | 10.18 | 11 | 58680 | 329 | 46627042 |
Blood hyposmosis | 25.08 | 10.18 | 6 | 58685 | 21 | 46627350 |
Injection site reaction | 24.34 | 10.18 | 15 | 58676 | 47834 | 46579537 |
Peripheral swelling | 24.33 | 10.18 | 109 | 58582 | 157962 | 46469409 |
Carcinoid tumour of the caecum | 24.26 | 10.18 | 6 | 58685 | 25 | 46627346 |
Barotrauma | 23.86 | 10.18 | 9 | 58682 | 182 | 46627189 |
Pulmonary hypoplasia | 23.38 | 10.18 | 10 | 58681 | 283 | 46627088 |
No adverse event | 23.33 | 10.18 | 7 | 58684 | 34224 | 46593147 |
Disease progression | 23.26 | 10.18 | 50 | 58641 | 91250 | 46536121 |
Multiple sclerosis relapse | 23.16 | 10.18 | 12 | 58679 | 42113 | 46585258 |
Haematoma | 22.92 | 10.18 | 90 | 58601 | 31782 | 46595589 |
Internal haemorrhage | 22.67 | 10.18 | 28 | 58663 | 4427 | 46622944 |
Mental status changes | 22.23 | 10.18 | 10 | 58681 | 38078 | 46589293 |
Abdominal discomfort | 22.22 | 10.18 | 106 | 58585 | 151059 | 46476312 |
Treatment failure | 22.08 | 10.18 | 53 | 58638 | 93034 | 46534337 |
Infection | 21.85 | 10.18 | 90 | 58601 | 133502 | 46493869 |
Shock haemorrhagic | 21.78 | 10.18 | 39 | 58652 | 8585 | 46618786 |
Abortion spontaneous | 21.76 | 10.18 | 14 | 58677 | 43632 | 46583739 |
Arrhythmia | 21.61 | 10.18 | 94 | 58597 | 34747 | 46592624 |
Tinnitus | 21.43 | 10.18 | 80 | 58611 | 27593 | 46599778 |
Product quality issue | 21.38 | 10.18 | 9 | 58682 | 35639 | 46591732 |
Purpura senile | 21.32 | 10.18 | 12 | 58679 | 623 | 46626748 |
Cerebellar syndrome | 21.32 | 10.18 | 24 | 58667 | 3441 | 46623930 |
Cornea verticillata | 21.07 | 10.18 | 6 | 58685 | 47 | 46627324 |
Renal impairment neonatal | 21.01 | 10.18 | 5 | 58686 | 17 | 46627354 |
Metastases to fallopian tube | 20.96 | 10.18 | 6 | 58685 | 48 | 46627323 |
Prerenal failure | 20.71 | 10.18 | 16 | 58675 | 1421 | 46625950 |
Myalgia | 20.58 | 10.18 | 241 | 58450 | 122847 | 46504524 |
Interstitial lung disease | 20.52 | 10.18 | 127 | 58564 | 53822 | 46573549 |
Intravascular haemolysis | 20.46 | 10.18 | 9 | 58682 | 273 | 46627098 |
Gastrointestinal disorder | 20.37 | 10.18 | 27 | 58664 | 59549 | 46567822 |
Palpitations | 20.37 | 10.18 | 196 | 58495 | 95063 | 46532308 |
Disturbance in attention | 20.23 | 10.18 | 86 | 58605 | 31474 | 46595897 |
Sinus arrest | 20.12 | 10.18 | 17 | 58674 | 1714 | 46625657 |
Thyroid stimulating immunoglobulin increased | 20.07 | 10.18 | 7 | 58684 | 112 | 46627259 |
Injection site swelling | 20.02 | 10.18 | 13 | 58678 | 40314 | 46587057 |
Atrioventricular block complete | 19.91 | 10.18 | 35 | 58656 | 7592 | 46619779 |
Dyspnoea | 19.86 | 10.18 | 814 | 57877 | 514734 | 46112637 |
Melaena | 19.63 | 10.18 | 78 | 58613 | 27694 | 46599677 |
Occult blood | 19.61 | 10.18 | 13 | 58678 | 907 | 46626464 |
Mental status changes postoperative | 19.37 | 10.18 | 8 | 58683 | 207 | 46627164 |
Renal aplasia | 19.16 | 10.18 | 8 | 58683 | 213 | 46627158 |
Oedema peripheral | 18.98 | 10.18 | 294 | 58397 | 159412 | 46467959 |
Histamine intolerance | 18.85 | 10.18 | 5 | 58686 | 29 | 46627342 |
Confusion postoperative | 18.82 | 10.18 | 8 | 58683 | 223 | 46627148 |
Intentional overdose | 18.77 | 10.18 | 33 | 58658 | 64911 | 46562460 |
Neutropenia | 18.47 | 10.18 | 105 | 58586 | 143099 | 46484272 |
Dehydration | 18.32 | 10.18 | 292 | 58399 | 159248 | 46468123 |
Urinary retention | 18.26 | 10.18 | 73 | 58618 | 25988 | 46601383 |
Joint swelling | 18.21 | 10.18 | 128 | 58563 | 165945 | 46461426 |
Injection site pruritus | 18.16 | 10.18 | 14 | 58677 | 39729 | 46587642 |
Blood creatine phosphokinase increased | 18.12 | 10.18 | 76 | 58615 | 27648 | 46599723 |
Painful respiration | 18.10 | 10.18 | 19 | 58672 | 2518 | 46624853 |
Putamen haemorrhage | 17.97 | 10.18 | 7 | 58684 | 155 | 46627216 |
Hypouricaemia | 17.84 | 10.18 | 7 | 58684 | 158 | 46627213 |
Psoas abscess | 17.64 | 10.18 | 9 | 58682 | 383 | 46626988 |
Blood uric acid increased | 17.62 | 10.18 | 24 | 58667 | 4177 | 46623194 |
Glomerulonephritis chronic | 17.60 | 10.18 | 7 | 58684 | 164 | 46627207 |
Vertigo positional | 17.53 | 10.18 | 19 | 58672 | 2611 | 46624760 |
Acute myocardial infarction | 17.46 | 10.18 | 83 | 58608 | 31841 | 46595530 |
Thirst | 17.46 | 10.18 | 41 | 58650 | 10935 | 46616436 |
Total lung capacity decreased | 17.42 | 10.18 | 13 | 58678 | 1096 | 46626275 |
Vital capacity decreased | 17.09 | 10.18 | 10 | 58681 | 559 | 46626812 |
Tubulointerstitial nephritis | 17.09 | 10.18 | 49 | 58642 | 14739 | 46612632 |
Heart rate | 17.04 | 10.18 | 5 | 58686 | 44 | 46627327 |
Multiple sclerosis | 17.02 | 10.18 | 5 | 58686 | 24786 | 46602585 |
Rash | 16.98 | 10.18 | 331 | 58360 | 356181 | 46271190 |
Vestibular migraine | 16.92 | 10.18 | 6 | 58685 | 101 | 46627270 |
Hypokalaemia | 16.83 | 10.18 | 177 | 58514 | 87847 | 46539524 |
Blood pressure inadequately controlled | 16.73 | 10.18 | 24 | 58667 | 4382 | 46622989 |
Hypoosmolar state | 16.67 | 10.18 | 7 | 58684 | 189 | 46627182 |
Female sterilisation | 16.66 | 10.18 | 10 | 58681 | 586 | 46626785 |
Productive cough | 16.61 | 10.18 | 115 | 58576 | 50600 | 46576771 |
Wrong strength | 16.57 | 10.18 | 5 | 58686 | 49 | 46627322 |
Transaminases increased | 16.53 | 10.18 | 74 | 58617 | 27687 | 46599684 |
Intentional product misuse | 16.48 | 10.18 | 21 | 58670 | 47107 | 46580264 |
Dermatosis | 16.42 | 10.18 | 8 | 58683 | 308 | 46627063 |
Exposure during pregnancy | 16.41 | 10.18 | 75 | 58616 | 108137 | 46519234 |
Hepatic function abnormal | 16.36 | 10.18 | 86 | 58605 | 34335 | 46593036 |
Ventricular extrasystoles | 16.17 | 10.18 | 40 | 58651 | 11023 | 46616348 |
Iron deficiency anaemia | 16.14 | 10.18 | 53 | 58638 | 17153 | 46610218 |
Diabetic ketoacidosis | 16.11 | 10.18 | 55 | 58636 | 18155 | 46609216 |
Prothrombin time shortened | 15.93 | 10.18 | 15 | 58676 | 1744 | 46625627 |
Potentiating drug interaction | 15.83 | 10.18 | 22 | 58669 | 3901 | 46623470 |
Sepsis | 15.82 | 10.18 | 103 | 58588 | 135911 | 46491460 |
Tarsal tunnel syndrome | 15.79 | 10.18 | 10 | 58681 | 645 | 46626726 |
Spider naevus | 15.78 | 10.18 | 6 | 58685 | 124 | 46627247 |
International normalised ratio increased | 15.77 | 10.18 | 107 | 58584 | 46776 | 46580595 |
Injection site bruising | 15.72 | 10.18 | 13 | 58678 | 35623 | 46591748 |
Chromaturia | 15.67 | 10.18 | 48 | 58643 | 14971 | 46612400 |
Chest wall mass | 15.65 | 10.18 | 5 | 58686 | 60 | 46627311 |
Neuropathy peripheral | 15.64 | 10.18 | 60 | 58631 | 90833 | 46536538 |
Serum serotonin increased | 15.61 | 10.18 | 6 | 58685 | 128 | 46627243 |
Mobility decreased | 15.59 | 10.18 | 33 | 58658 | 60561 | 46566810 |
Hypomagnesaemia | 15.39 | 10.18 | 62 | 58629 | 22148 | 46605223 |
Plasma cell myeloma | 15.36 | 10.18 | 20 | 58671 | 44458 | 46582913 |
C-reactive protein increased | 15.33 | 10.18 | 126 | 58565 | 58464 | 46568907 |
Sensitivity to weather change | 15.30 | 10.18 | 26 | 58665 | 5490 | 46621881 |
Adverse drug reaction | 15.27 | 10.18 | 20 | 58671 | 44342 | 46583029 |
Vestibular disorder | 15.03 | 10.18 | 13 | 58678 | 1353 | 46626018 |
Cor pulmonale acute | 15.02 | 10.18 | 8 | 58683 | 372 | 46626999 |
Cerebral haemorrhage | 14.97 | 10.18 | 73 | 58618 | 28298 | 46599073 |
Walking disability | 14.94 | 10.18 | 13 | 58678 | 1365 | 46626006 |
Contraindicated product administered | 14.93 | 10.18 | 51 | 58640 | 79896 | 46547475 |
Systemic lupus erythematosus | 14.76 | 10.18 | 38 | 58653 | 65142 | 46562229 |
Pneumobilia | 14.57 | 10.18 | 6 | 58685 | 154 | 46627217 |
Lip infection | 14.34 | 10.18 | 5 | 58686 | 80 | 46627291 |
Full blood count decreased | 14.33 | 10.18 | 5 | 58686 | 22206 | 46605165 |
Nasal congestion | 14.31 | 10.18 | 24 | 58667 | 48089 | 46579282 |
Dyspnoea at rest | 14.30 | 10.18 | 20 | 58671 | 3568 | 46623803 |
Bradyarrhythmia | 14.27 | 10.18 | 15 | 58676 | 1991 | 46625380 |
Metastases to bladder | 14.19 | 10.18 | 6 | 58685 | 165 | 46627206 |
Hyperuricaemia | 14.11 | 10.18 | 23 | 58668 | 4694 | 46622677 |
Retroperitoneal haematoma | 14.09 | 10.18 | 17 | 58674 | 2623 | 46624748 |
Gastroenteritis | 14.00 | 10.18 | 64 | 58627 | 24155 | 46603216 |
Binocular eye movement disorder | 13.97 | 10.18 | 4 | 58687 | 32 | 46627339 |
Cerebral haematoma | 13.89 | 10.18 | 19 | 58672 | 3320 | 46624051 |
Cardiorenal syndrome | 13.80 | 10.18 | 9 | 58682 | 611 | 46626760 |
Unevaluable event | 13.77 | 10.18 | 23 | 58668 | 46152 | 46581219 |
Blood sodium decreased | 13.76 | 10.18 | 59 | 58632 | 21667 | 46605704 |
Glomerular filtration rate decreased | 13.76 | 10.18 | 39 | 58652 | 11655 | 46615716 |
Therapy non-responder | 13.71 | 10.18 | 19 | 58672 | 41133 | 46586238 |
Decreased appetite | 13.51 | 10.18 | 329 | 58362 | 193507 | 46433864 |
Staphylococcal infection | 13.51 | 10.18 | 15 | 58676 | 35756 | 46591615 |
Aortic dissection | 13.33 | 10.18 | 13 | 58678 | 1579 | 46625792 |
Aphasia | 13.32 | 10.18 | 71 | 58620 | 28496 | 46598875 |
Hypochloraemia | 13.31 | 10.18 | 14 | 58677 | 1859 | 46625512 |
Glossitis | 13.28 | 10.18 | 17 | 58674 | 2786 | 46624585 |
Hallucinations, mixed | 13.22 | 10.18 | 20 | 58671 | 3829 | 46623542 |
Cardiac murmur functional | 13.18 | 10.18 | 4 | 58687 | 40 | 46627331 |
Accidental exposure to product | 13.17 | 10.18 | 5 | 58686 | 21076 | 46606295 |
Miosis | 13.00 | 10.18 | 27 | 58664 | 6630 | 46620741 |
Crystal arthropathy | 12.95 | 10.18 | 6 | 58685 | 206 | 46627165 |
Retroperitoneal fibrosis | 12.94 | 10.18 | 7 | 58684 | 336 | 46627035 |
Subarachnoid haemorrhage | 12.93 | 10.18 | 37 | 58654 | 11116 | 46616255 |
Treatment noncompliance | 12.93 | 10.18 | 11 | 58680 | 29720 | 46597651 |
Drug metabolising enzyme decreased | 12.89 | 10.18 | 3 | 58688 | 9 | 46627362 |
Pericarditis | 12.88 | 10.18 | 7 | 58684 | 23920 | 46603451 |
Eczema nummular | 12.77 | 10.18 | 6 | 58685 | 213 | 46627158 |
Device capturing issue | 12.76 | 10.18 | 4 | 58687 | 45 | 46627326 |
Polyuria | 12.69 | 10.18 | 28 | 58663 | 7167 | 46620204 |
Clostridium difficile infection | 12.58 | 10.18 | 8 | 58683 | 25095 | 46602276 |
Blood urea increased | 12.50 | 10.18 | 64 | 58627 | 25288 | 46602083 |
Febrile neutropenia | 12.40 | 10.18 | 69 | 58622 | 94558 | 46532813 |
Tenderness | 12.36 | 10.18 | 3 | 58688 | 16878 | 46610493 |
Gastrointestinal haemorrhage | 12.27 | 10.18 | 150 | 58541 | 77223 | 46550148 |
Endometrial cancer stage I | 12.27 | 10.18 | 6 | 58685 | 233 | 46627138 |
Arthralgia | 12.23 | 10.18 | 357 | 58334 | 364246 | 46263125 |
Wrong technique in product usage process | 12.11 | 10.18 | 32 | 58659 | 54390 | 46572981 |
Malaise | 12.03 | 10.18 | 520 | 58171 | 330712 | 46296659 |
Seizure | 11.99 | 10.18 | 98 | 58593 | 122956 | 46504415 |
Drug monitoring procedure not performed | 11.92 | 10.18 | 7 | 58684 | 394 | 46626977 |
Anaemia folate deficiency | 11.90 | 10.18 | 6 | 58685 | 249 | 46627122 |
Pharyngeal enanthema | 11.89 | 10.18 | 4 | 58687 | 57 | 46627314 |
Electrolyte imbalance | 11.87 | 10.18 | 48 | 58643 | 17178 | 46610193 |
Pregnancy | 11.85 | 10.18 | 10 | 58681 | 27127 | 46600244 |
Ischaemic stroke | 11.84 | 10.18 | 47 | 58644 | 16675 | 46610696 |
Drug therapeutic incompatibility | 11.83 | 10.18 | 4 | 58687 | 58 | 46627313 |
Gastroenteritis viral | 11.82 | 10.18 | 4 | 58687 | 18115 | 46609256 |
Thrombosis | 11.71 | 10.18 | 34 | 58657 | 56035 | 46571336 |
Loss of personal independence in daily activities | 11.71 | 10.18 | 35 | 58656 | 57148 | 46570223 |
Hepatic enzyme increased | 11.63 | 10.18 | 58 | 58633 | 81729 | 46545642 |
Pain in jaw | 11.54 | 10.18 | 19 | 58672 | 38353 | 46589018 |
Foetal malformation | 11.48 | 10.18 | 5 | 58686 | 148 | 46627223 |
Brain stem stroke | 11.45 | 10.18 | 6 | 58685 | 270 | 46627101 |
Labelled drug-drug interaction medication error | 11.43 | 10.18 | 31 | 58660 | 9030 | 46618341 |
Therapy cessation | 11.40 | 10.18 | 10 | 58681 | 26619 | 46600752 |
Intraventricular haemorrhage | 11.39 | 10.18 | 13 | 58678 | 1892 | 46625479 |
Retinopathy of prematurity | 11.37 | 10.18 | 6 | 58685 | 274 | 46627097 |
Transient ischaemic attack | 11.34 | 10.18 | 79 | 58612 | 34824 | 46592547 |
Proteinuria | 11.30 | 10.18 | 46 | 58645 | 16507 | 46610864 |
Anti-thyroid antibody positive | 11.25 | 10.18 | 7 | 58684 | 438 | 46626933 |
Iron deficiency | 11.24 | 10.18 | 23 | 58668 | 5590 | 46621781 |
Base excess decreased | 11.19 | 10.18 | 4 | 58687 | 69 | 46627302 |
Product impurity | 11.19 | 10.18 | 4 | 58687 | 69 | 46627302 |
Lordosis | 11.19 | 10.18 | 6 | 58685 | 283 | 46627088 |
Aplasia pure red cell | 11.16 | 10.18 | 20 | 58671 | 4405 | 46622966 |
Carcinoid tumour | 11.09 | 10.18 | 6 | 58685 | 288 | 46627083 |
Blood pressure systolic increased | 11.09 | 10.18 | 68 | 58623 | 28719 | 46598652 |
Delayed fontanelle closure | 11.09 | 10.18 | 3 | 58688 | 19 | 46627352 |
Blood sodium abnormal | 11.05 | 10.18 | 8 | 58683 | 644 | 46626727 |
Polyneuropathy | 11.04 | 10.18 | 36 | 58655 | 11608 | 46615763 |
Visual acuity reduced transiently | 11.03 | 10.18 | 5 | 58686 | 163 | 46627208 |
Spinal osteoarthritis | 11.03 | 10.18 | 41 | 58650 | 14110 | 46613261 |
Hypoaesthesia | 10.98 | 10.18 | 96 | 58595 | 118773 | 46508598 |
Resorption bone increased | 10.96 | 10.18 | 10 | 58681 | 1117 | 46626254 |
Congestive cardiomyopathy | 10.95 | 10.18 | 23 | 58668 | 5690 | 46621681 |
Stasis dermatitis | 10.95 | 10.18 | 8 | 58683 | 653 | 46626718 |
Gastritis bacterial | 10.93 | 10.18 | 4 | 58687 | 74 | 46627297 |
Device dislocation | 10.86 | 10.18 | 7 | 58684 | 21795 | 46605576 |
Complication associated with device | 10.81 | 10.18 | 3 | 58688 | 15438 | 46611933 |
Procalcitonin increased | 10.81 | 10.18 | 8 | 58683 | 666 | 46626705 |
Dyscalculia | 10.71 | 10.18 | 3 | 58688 | 22 | 46627349 |
Hepatitis cholestatic | 10.68 | 10.18 | 25 | 58666 | 6652 | 46620719 |
Infusion related reaction | 10.60 | 10.18 | 79 | 58612 | 101129 | 46526242 |
Incarcerated incisional hernia | 10.59 | 10.18 | 3 | 58688 | 23 | 46627348 |
Chemotherapeutic drug level increased | 10.57 | 10.18 | 5 | 58686 | 180 | 46627191 |
Laboratory test abnormal | 10.50 | 10.18 | 8 | 58683 | 22839 | 46604532 |
Blood pressure decreased | 10.49 | 10.18 | 114 | 58577 | 57045 | 46570326 |
Drug dependence | 10.45 | 10.18 | 6 | 58685 | 19895 | 46607476 |
Vitamin B12 decreased | 10.37 | 10.18 | 15 | 58676 | 2760 | 46624611 |
Skin texture abnormal | 10.36 | 10.18 | 6 | 58685 | 329 | 46627042 |
Necrotising myositis | 10.34 | 10.18 | 6 | 58685 | 330 | 46627041 |
Stress urinary incontinence | 10.29 | 10.18 | 13 | 58678 | 2103 | 46625268 |
Agranulocytosis | 10.25 | 10.18 | 55 | 58636 | 22130 | 46605241 |
White blood cell count decreased | 10.21 | 10.18 | 91 | 58600 | 112140 | 46515231 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyperkalaemia | 150.84 | 10.50 | 320 | 45449 | 65690 | 29841019 |
General physical health deterioration | 146.36 | 10.50 | 408 | 45361 | 99536 | 29807173 |
Acute kidney injury | 135.24 | 10.50 | 795 | 44974 | 273047 | 29633662 |
Death | 133.69 | 10.50 | 213 | 45556 | 357070 | 29549639 |
Completed suicide | 126.87 | 10.50 | 6 | 45763 | 99486 | 29807223 |
Product monitoring error | 126.54 | 10.50 | 59 | 45710 | 1682 | 29905027 |
Haematochezia | 86.44 | 10.50 | 173 | 45596 | 34049 | 29872660 |
Product dose omission issue | 75.62 | 10.50 | 23 | 45746 | 91608 | 29815101 |
Drug abuse | 72.60 | 10.50 | 18 | 45751 | 82054 | 29824655 |
Toxicity to various agents | 72.47 | 10.50 | 99 | 45670 | 177084 | 29729625 |
Bradycardia | 62.43 | 10.50 | 231 | 45538 | 65295 | 29841414 |
Hypertension | 58.06 | 10.50 | 350 | 45419 | 121004 | 29785705 |
Neutropenia | 50.34 | 10.50 | 74 | 45695 | 128466 | 29778243 |
Dizziness | 49.22 | 10.50 | 484 | 45285 | 194425 | 29712284 |
Pulmonary hypoplasia | 48.93 | 10.50 | 20 | 45749 | 411 | 29906298 |
Cardiac failure | 48.08 | 10.50 | 253 | 45516 | 83165 | 29823544 |
Product prescribing error | 46.38 | 10.50 | 88 | 45681 | 16645 | 29890064 |
Angina pectoris | 44.56 | 10.50 | 122 | 45647 | 29396 | 29877313 |
Renal impairment | 44.25 | 10.50 | 249 | 45520 | 83935 | 29822774 |
Interstitial lung disease | 43.62 | 10.50 | 195 | 45574 | 60002 | 29846707 |
Pemphigoid | 37.97 | 10.50 | 52 | 45717 | 7476 | 29899233 |
Plasma cell myeloma | 36.51 | 10.50 | 18 | 45751 | 53444 | 29853265 |
Electrolyte imbalance | 36.32 | 10.50 | 64 | 45705 | 11436 | 29895273 |
Vitamin D deficiency | 36.09 | 10.50 | 42 | 45727 | 5128 | 29901581 |
Presyncope | 34.49 | 10.50 | 76 | 45693 | 15980 | 29890729 |
Anencephaly | 33.87 | 10.50 | 11 | 45758 | 113 | 29906596 |
Nipple inflammation | 33.80 | 10.50 | 10 | 45759 | 73 | 29906636 |
Lymphocyte count abnormal | 33.61 | 10.50 | 17 | 45752 | 581 | 29906128 |
Renal artery thrombosis | 33.25 | 10.50 | 14 | 45755 | 311 | 29906398 |
Drug ineffective | 32.60 | 10.50 | 348 | 45421 | 340039 | 29566670 |
Cerebral infarction | 31.22 | 10.50 | 100 | 45669 | 26273 | 29880436 |
Drug interaction | 30.28 | 10.50 | 450 | 45319 | 199118 | 29707591 |
Patient dissatisfaction with treatment | 30.27 | 10.50 | 9 | 45760 | 67 | 29906642 |
Disease progression | 30.26 | 10.50 | 47 | 45722 | 79827 | 29826882 |
Myalgia | 29.81 | 10.50 | 210 | 45559 | 76457 | 29830252 |
C-reactive protein decreased | 29.06 | 10.50 | 22 | 45747 | 1556 | 29905153 |
Blood pressure increased | 28.54 | 10.50 | 198 | 45571 | 71730 | 29834979 |
Seizure | 28.54 | 10.50 | 68 | 45701 | 98407 | 29808302 |
Agitation | 27.78 | 10.50 | 25 | 45744 | 54048 | 29852661 |
Labelled drug-drug interaction medication error | 27.46 | 10.50 | 54 | 45715 | 10484 | 29896225 |
Hospitalisation | 27.25 | 10.50 | 17 | 45752 | 44302 | 29862407 |
Oedema peripheral | 27.22 | 10.50 | 264 | 45505 | 105568 | 29801141 |
Neuropathy peripheral | 27.15 | 10.50 | 41 | 45728 | 70434 | 29836275 |
Arrhythmia | 26.74 | 10.50 | 111 | 45658 | 33058 | 29873651 |
Blood creatinine increased | 26.55 | 10.50 | 234 | 45535 | 91141 | 29815568 |
Blood cholesterol | 26.37 | 10.50 | 9 | 45760 | 109 | 29906600 |
Hyperuricaemia | 25.78 | 10.50 | 43 | 45726 | 7351 | 29899358 |
Cardiac arrest | 25.43 | 10.50 | 66 | 45703 | 92784 | 29813925 |
Off label use | 25.41 | 10.50 | 251 | 45518 | 249039 | 29657670 |
Nipple disorder | 25.04 | 10.50 | 10 | 45759 | 193 | 29906516 |
Peripheral arterial occlusive disease | 25.02 | 10.50 | 35 | 45734 | 5133 | 29901576 |
Respiratory arrest | 24.74 | 10.50 | 7 | 45762 | 29251 | 29877458 |
Joint contracture | 24.29 | 10.50 | 21 | 45748 | 1794 | 29904915 |
Lactic acidosis | 24.03 | 10.50 | 103 | 45666 | 31110 | 29875599 |
Colitis | 23.96 | 10.50 | 102 | 45667 | 30718 | 29875991 |
Hypertensive crisis | 23.21 | 10.50 | 44 | 45725 | 8313 | 29898396 |
Intentional product misuse | 23.17 | 10.50 | 12 | 45757 | 34655 | 29872054 |
Dyspnoea | 22.50 | 10.50 | 667 | 45102 | 332628 | 29574081 |
Pain | 22.44 | 10.50 | 163 | 45606 | 172478 | 29734231 |
Intestinal haemorrhage | 22.33 | 10.50 | 26 | 45743 | 3175 | 29903534 |
Hemiataxia | 22.21 | 10.50 | 6 | 45763 | 30 | 29906679 |
Hyponatraemia | 22.12 | 10.50 | 177 | 45592 | 67025 | 29839684 |
Mucosal haemorrhage | 21.84 | 10.50 | 18 | 45751 | 1440 | 29905269 |
Mental status changes | 21.74 | 10.50 | 15 | 45754 | 37064 | 29869645 |
Sepsis | 21.64 | 10.50 | 133 | 45636 | 146262 | 29760447 |
Acute cutaneous lupus erythematosus | 21.54 | 10.50 | 7 | 45762 | 72 | 29906637 |
Diabetes mellitus inadequate control | 21.54 | 10.50 | 55 | 45714 | 12707 | 29894002 |
Pneumonia | 21.39 | 10.50 | 371 | 45398 | 333935 | 29572774 |
Blood glucose fluctuation | 21.10 | 10.50 | 27 | 45742 | 3634 | 29903075 |
Gastrointestinal ischaemia | 21.08 | 10.50 | 9 | 45760 | 207 | 29906502 |
Food aversion | 21.07 | 10.50 | 10 | 45759 | 297 | 29906412 |
Febrile neutropenia | 20.83 | 10.50 | 88 | 45681 | 106605 | 29800104 |
Haematoma | 20.77 | 10.50 | 82 | 45687 | 23871 | 29882838 |
Hypoxia | 20.26 | 10.50 | 26 | 45743 | 47828 | 29858881 |
Urinary hesitation | 20.18 | 10.50 | 21 | 45748 | 2263 | 29904446 |
Nervous system neoplasm | 20.05 | 10.50 | 8 | 45761 | 154 | 29906555 |
Oral lichen planus | 19.37 | 10.50 | 8 | 45761 | 169 | 29906540 |
Vasculitic rash | 19.28 | 10.50 | 14 | 45755 | 929 | 29905780 |
Duodenal ulcer | 19.19 | 10.50 | 45 | 45724 | 9856 | 29896853 |
Eczema eyelids | 19.03 | 10.50 | 5 | 45764 | 22 | 29906687 |
Gamma-glutamyltransferase increased | 18.98 | 10.50 | 92 | 45677 | 29258 | 29877451 |
Mixed liver injury | 18.83 | 10.50 | 19 | 45750 | 1974 | 29904735 |
Basilar artery thrombosis | 18.35 | 10.50 | 7 | 45762 | 119 | 29906590 |
Jaundice | 18.32 | 10.50 | 98 | 45671 | 32388 | 29874321 |
Pallor | 18.20 | 10.50 | 72 | 45697 | 20977 | 29885732 |
Tonsillar ulcer | 18.16 | 10.50 | 8 | 45761 | 199 | 29906510 |
Anxiety disorder due to a general medical condition | 17.91 | 10.50 | 4 | 45765 | 7 | 29906702 |
Atrioventricular block second degree | 17.85 | 10.50 | 23 | 45746 | 3117 | 29903592 |
Congenital renal disorder | 17.63 | 10.50 | 6 | 45763 | 72 | 29906637 |
Macular ischaemia | 17.20 | 10.50 | 6 | 45763 | 78 | 29906631 |
Unevaluable event | 17.17 | 10.50 | 14 | 45755 | 31771 | 29874938 |
Blood creatine phosphokinase increased | 16.97 | 10.50 | 120 | 45649 | 43728 | 29862981 |
Hepatic function abnormal | 16.94 | 10.50 | 116 | 45653 | 41829 | 29864880 |
Blood pressure fluctuation | 16.89 | 10.50 | 62 | 45707 | 17441 | 29889268 |
Cerebral haematoma | 16.75 | 10.50 | 27 | 45742 | 4487 | 29902222 |
Paresis cranial nerve | 16.66 | 10.50 | 6 | 45763 | 86 | 29906623 |
Congenital vas deferens absence | 16.61 | 10.50 | 5 | 45764 | 39 | 29906670 |
Congenital muscle absence | 16.61 | 10.50 | 5 | 45764 | 39 | 29906670 |
Hallucination | 16.61 | 10.50 | 31 | 45738 | 49028 | 29857681 |
Skull malformation | 16.54 | 10.50 | 9 | 45760 | 358 | 29906351 |
Choroidal detachment | 16.52 | 10.50 | 9 | 45760 | 359 | 29906350 |
Supine hypertension | 16.51 | 10.50 | 8 | 45761 | 249 | 29906460 |
Blood pressure inadequately controlled | 16.49 | 10.50 | 20 | 45749 | 2550 | 29904159 |
Device lead damage | 16.46 | 10.50 | 3 | 45766 | 0 | 29906709 |
Incarcerated inguinal hernia | 16.41 | 10.50 | 6 | 45763 | 90 | 29906619 |
Xanthopsia | 16.36 | 10.50 | 7 | 45762 | 162 | 29906547 |
Syncope | 16.35 | 10.50 | 200 | 45569 | 84703 | 29822006 |
Muscle rupture | 16.10 | 10.50 | 18 | 45751 | 2103 | 29904606 |
Fracture | 15.92 | 10.50 | 31 | 45738 | 5975 | 29900734 |
Retinal artery occlusion | 15.81 | 10.50 | 16 | 45753 | 1668 | 29905041 |
Oliguria | 15.74 | 10.50 | 35 | 45734 | 7404 | 29899305 |
Hepatic ischaemia | 15.71 | 10.50 | 9 | 45760 | 396 | 29906313 |
Sedation | 15.66 | 10.50 | 3 | 45766 | 16370 | 29890339 |
Treatment failure | 15.57 | 10.50 | 18 | 45751 | 34661 | 29872048 |
Pancreatitis acute | 15.51 | 10.50 | 79 | 45690 | 25616 | 29881093 |
Alopecia universalis | 15.51 | 10.50 | 5 | 45764 | 50 | 29906659 |
Shock hypoglycaemic | 15.36 | 10.50 | 6 | 45763 | 109 | 29906600 |
Hypotension | 15.33 | 10.50 | 408 | 45361 | 200157 | 29706552 |
Gastrointestinal disorder | 15.27 | 10.50 | 84 | 45685 | 28053 | 29878656 |
Oligohydramnios | 15.09 | 10.50 | 8 | 45761 | 302 | 29906407 |
Aortic valve incompetence | 15.03 | 10.50 | 27 | 45742 | 4896 | 29901813 |
Abdominal pain lower | 14.94 | 10.50 | 38 | 45731 | 8760 | 29897949 |
Prolonged expiration | 14.93 | 10.50 | 7 | 45762 | 202 | 29906507 |
Primary hyperaldosteronism | 14.85 | 10.50 | 5 | 45764 | 58 | 29906651 |
Drug dependence | 14.79 | 10.50 | 7 | 45762 | 21288 | 29885421 |
Full blood count decreased | 14.78 | 10.50 | 3 | 45766 | 15714 | 29890995 |
Rhabdomyolysis | 14.60 | 10.50 | 155 | 45614 | 63425 | 29843284 |
Renin increased | 14.55 | 10.50 | 5 | 45764 | 62 | 29906647 |
Papillary renal cell carcinoma | 14.52 | 10.50 | 6 | 45763 | 127 | 29906582 |
Coronavirus infection | 14.48 | 10.50 | 22 | 45747 | 3476 | 29903233 |
Desmoplastic melanoma | 14.38 | 10.50 | 3 | 45766 | 3 | 29906706 |
Eczema | 14.31 | 10.50 | 49 | 45720 | 13320 | 29893389 |
Therapeutic product effect decreased | 14.27 | 10.50 | 14 | 45755 | 29062 | 29877647 |
Sinusitis | 14.24 | 10.50 | 18 | 45751 | 33327 | 29873382 |
White blood cell count decreased | 14.16 | 10.50 | 73 | 45696 | 83874 | 29822835 |
Melaena | 13.87 | 10.50 | 91 | 45678 | 32346 | 29874363 |
COVID-19 | 13.83 | 10.50 | 5 | 45764 | 17873 | 29888836 |
Multiple drug therapy | 13.82 | 10.50 | 7 | 45762 | 240 | 29906469 |
Excessive eye blinking | 13.71 | 10.50 | 7 | 45762 | 244 | 29906465 |
Cardiovascular insufficiency | 13.66 | 10.50 | 14 | 45755 | 1482 | 29905227 |
Vasoplegia syndrome | 13.66 | 10.50 | 13 | 45756 | 1258 | 29905451 |
Basal ganglia haemorrhage | 13.65 | 10.50 | 11 | 45758 | 852 | 29905857 |
Total cholesterol/HDL ratio increased | 13.59 | 10.50 | 6 | 45763 | 150 | 29906559 |
Therapy non-responder | 13.54 | 10.50 | 15 | 45754 | 29438 | 29877271 |
Hypozincaemia | 13.52 | 10.50 | 3 | 45766 | 5 | 29906704 |
Hepatitis acute | 13.52 | 10.50 | 32 | 45737 | 7051 | 29899658 |
Condition aggravated | 13.42 | 10.50 | 290 | 45479 | 137576 | 29769133 |
Drug resistance | 13.41 | 10.50 | 7 | 45762 | 20126 | 29886583 |
Brain stem infarction | 13.36 | 10.50 | 13 | 45756 | 1293 | 29905416 |
Vertebral artery stenosis | 13.31 | 10.50 | 6 | 45763 | 158 | 29906551 |
Product quality issue | 13.31 | 10.50 | 6 | 45763 | 18768 | 29887941 |
Orthostatic hypotension | 13.29 | 10.50 | 72 | 45697 | 23907 | 29882802 |
No adverse event | 13.26 | 10.50 | 5 | 45764 | 17414 | 29889295 |
Renal ischaemia | 13.26 | 10.50 | 9 | 45760 | 536 | 29906173 |
Prothrombin time shortened | 13.21 | 10.50 | 14 | 45755 | 1541 | 29905168 |
Rhinalgia | 13.20 | 10.50 | 8 | 45761 | 391 | 29906318 |
Periorbital discomfort | 13.20 | 10.50 | 4 | 45765 | 32 | 29906677 |
Vascular stent thrombosis | 13.07 | 10.50 | 17 | 45752 | 2326 | 29904383 |
Palmar-plantar erythrodysaesthesia syndrome | 12.96 | 10.50 | 51 | 45718 | 14819 | 29891890 |
Cranial sutures widening | 12.95 | 10.50 | 5 | 45764 | 88 | 29906621 |
Mechanical urticaria | 12.84 | 10.50 | 5 | 45764 | 90 | 29906619 |
Hepatocellular carcinoma | 12.82 | 10.50 | 38 | 45731 | 9572 | 29897137 |
Neurologic neglect syndrome | 12.71 | 10.50 | 6 | 45763 | 176 | 29906533 |
Thrombocytopenia | 12.69 | 10.50 | 141 | 45628 | 136903 | 29769806 |
Adrenal insufficiency | 12.68 | 10.50 | 40 | 45729 | 10423 | 29896286 |
Unresponsive to stimuli | 12.65 | 10.50 | 13 | 45756 | 26406 | 29880303 |
Hypoglycaemia | 12.51 | 10.50 | 126 | 45643 | 50855 | 29855854 |
Product use in unapproved indication | 12.47 | 10.50 | 64 | 45705 | 73629 | 29833080 |
Myopia | 12.43 | 10.50 | 9 | 45760 | 594 | 29906115 |
Aortic valve disease mixed | 12.36 | 10.50 | 5 | 45764 | 100 | 29906609 |
Lip ulceration | 12.32 | 10.50 | 10 | 45759 | 783 | 29905926 |
Mesenteric artery thrombosis | 12.24 | 10.50 | 8 | 45761 | 447 | 29906262 |
Coronary artery stenosis | 12.23 | 10.50 | 36 | 45733 | 9034 | 29897675 |
Hypochromic anaemia | 12.20 | 10.50 | 10 | 45759 | 794 | 29905915 |
Subileus | 12.19 | 10.50 | 19 | 45750 | 3068 | 29903641 |
Glycosylated haemoglobin increased | 12.16 | 10.50 | 37 | 45732 | 9454 | 29897255 |
Renal failure | 12.14 | 10.50 | 270 | 45499 | 128696 | 29778013 |
Pterygium | 11.96 | 10.50 | 5 | 45764 | 109 | 29906600 |
Anti-erythropoietin antibody negative | 11.95 | 10.50 | 6 | 45763 | 202 | 29906507 |
Neuroleptic malignant syndrome | 11.88 | 10.50 | 5 | 45764 | 16290 | 29890419 |
Stomal hernia | 11.88 | 10.50 | 5 | 45764 | 111 | 29906598 |
Antinuclear antibody increased | 11.68 | 10.50 | 6 | 45763 | 212 | 29906497 |
Neonatal hypotension | 11.55 | 10.50 | 5 | 45764 | 119 | 29906590 |
Wrong dose | 11.46 | 10.50 | 7 | 45762 | 347 | 29906362 |
Neurotoxicity | 11.43 | 10.50 | 3 | 45766 | 13179 | 29893530 |
Breast pain | 11.37 | 10.50 | 12 | 45757 | 1315 | 29905394 |
Generalised tonic-clonic seizure | 11.34 | 10.50 | 8 | 45761 | 19543 | 29887166 |
Gastric dilatation | 11.28 | 10.50 | 8 | 45761 | 511 | 29906198 |
Nocturnal dyspnoea | 11.24 | 10.50 | 8 | 45761 | 514 | 29906195 |
Acute on chronic liver failure | 11.22 | 10.50 | 5 | 45764 | 128 | 29906581 |
Respiratory failure | 11.22 | 10.50 | 99 | 45670 | 100543 | 29806166 |
Depersonalisation/derealisation disorder | 11.17 | 10.50 | 8 | 45761 | 519 | 29906190 |
Anxiety | 11.11 | 10.50 | 86 | 45683 | 89785 | 29816924 |
Costovertebral angle tenderness | 11.10 | 10.50 | 3 | 45766 | 15 | 29906694 |
Aortic dissection | 11.03 | 10.50 | 16 | 45753 | 2426 | 29904283 |
Lymphocyte count | 11.00 | 10.50 | 4 | 45765 | 59 | 29906650 |
Skull fracture | 10.94 | 10.50 | 10 | 45759 | 919 | 29905790 |
Cytomegalovirus infection | 10.94 | 10.50 | 12 | 45757 | 23662 | 29883047 |
Fatigue | 10.86 | 10.50 | 391 | 45378 | 320282 | 29586427 |
Fluid overload | 10.83 | 10.50 | 8 | 45761 | 19084 | 29887625 |
Idiopathic pulmonary fibrosis | 10.78 | 10.50 | 21 | 45748 | 4048 | 29902661 |
Septic encephalopathy | 10.76 | 10.50 | 4 | 45765 | 63 | 29906646 |
Influenza like illness | 10.75 | 10.50 | 14 | 45755 | 25591 | 29881118 |
Sinus rhythm | 10.71 | 10.50 | 6 | 45763 | 253 | 29906456 |
Catheter site cellulitis | 10.67 | 10.50 | 5 | 45764 | 144 | 29906565 |
Tongue haematoma | 10.61 | 10.50 | 5 | 45764 | 146 | 29906563 |
Toxic skin eruption | 10.61 | 10.50 | 39 | 45730 | 10976 | 29895733 |
Tetany | 10.53 | 10.50 | 9 | 45760 | 757 | 29905952 |
Facial paresis | 10.51 | 10.50 | 17 | 45752 | 2833 | 29903876 |
Source | Code | Description |
---|---|---|
ATC | C09CA06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN Angiotensin II receptor blockers (ARBs), plain |
ATC | C09DA06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and diuretics |
ATC | C09DB07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DX06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
MeSH PA | D047228 | Angiotensin II Type 1 Receptor Blockers |
MeSH PA | D057911 | Angiotensin Receptor Antagonists |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
FDA MoA | N0000000070 | Angiotensin 2 Receptor Antagonists |
FDA EPC | N0000175561 | Angiotensin 2 Receptor Blocker |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Diabetic renal disease | off-label use | 127013003 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Nondiabetic Proteinuric Nephropathy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Oliguria | contraindication | 83128009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Surgical procedure | contraindication | 387713003 | |
Azotemia | contraindication | 445009001 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.25 | acidic |
pKa2 | 3.2 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Type-1 angiotensin II receptor | GPCR | ANTAGONIST | UNKNOWN | CHEMBL | |||||
Adenosine receptor A3 | GPCR | Ki | 6.16 | CHEMBL | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 5.76 | CHEMBL | |||||
Cytochrome P450 2C9 | Enzyme | IC50 | 5.52 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.52 | CHEMBL | |||||
Thromboxane-A synthase | Enzyme | IC50 | 5.51 | CHEMBL | |||||
Beta-3 adrenergic receptor | GPCR | Ki | 5.49 | CHEMBL | |||||
Epidermal growth factor receptor | Kinase | IC50 | 5.48 | CHEMBL | |||||
Receptor tyrosine-protein kinase erbB-2 | Kinase | IC50 | 5.23 | CHEMBL | |||||
Cytochrome P450 3A4 | Enzyme | IC50 | 5.05 | CHEMBL | |||||
Cruzipain | Enzyme | IC50 | 4.38 | CHEMBL | |||||
Type-1 angiotensin II receptor | GPCR | IC50 | 6.96 | CHEMBL | |||||
Type-1 angiotensin II receptor | GPCR | Ki | 9.19 | CHEMBL |
ID | Source |
---|---|
4021148 | VUID |
N0000179517 | NUI |
D00522 | KEGG_DRUG |
139481-59-7 | SECONDARY_CAS_RN |
4021148 | VANDF |
4021151 | VANDF |
C0527379 | UMLSCUI |
C0717550 | UMLSCUI |
CHEBI:3348 | CHEBI |
CHEBI:149509 | CHEBI |
CHEMBL1014 | ChEMBL_ID |
DB00796 | DRUGBANK_ID |
C077793 | MESH_SUPPLEMENTAL_RECORD_UI |
2540 | PUBCHEM_CID |
8352 | IUPHAR_LIGAND_ID |
C081643 | MESH_SUPPLEMENTAL_RECORD_UI |
7239 | INN_ID |
S8Q36MD2XX | UNII |
2541 | PUBCHEM_CID |
587 | IUPHAR_LIGAND_ID |
DB13919 | DRUGBANK_ID |
135481 | RXNORM |
188909 | MMSL |
7490 | MMSL |
d04322 | MMSL |
007275 | NDDF |
007276 | NDDF |
108587008 | SNOMEDCT_US |
372512008 | SNOMEDCT_US |
386878000 | SNOMEDCT_US |
None