Stem definition | Drug id | CAS RN |
---|---|---|
diuretics, sulfamoylbenzoic acid derivatives | 1433 | 26807-65-8 |
Dose | Unit | Route |
---|---|---|
2.50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.59 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 7 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.20 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
July 6, 1983 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyponatraemia | 1324.96 | 13.59 | 705 | 22793 | 101434 | 56167135 |
Hypokalaemia | 548.18 | 13.59 | 391 | 23107 | 94046 | 56174523 |
Acute kidney injury | 235.68 | 13.59 | 386 | 23112 | 240377 | 56028192 |
Inappropriate antidiuretic hormone secretion | 155.36 | 13.59 | 87 | 23411 | 13669 | 56254900 |
Confusional state | 114.72 | 13.59 | 262 | 23236 | 207893 | 56060676 |
Hypochloraemia | 113.74 | 13.59 | 38 | 23460 | 1674 | 56266895 |
Drug interaction | 103.60 | 13.59 | 253 | 23245 | 209502 | 56059067 |
Hypomagnesaemia | 97.54 | 13.59 | 82 | 23416 | 24933 | 56243636 |
Burning mouth syndrome | 87.88 | 13.59 | 23 | 23475 | 425 | 56268144 |
Hyponatraemic seizure | 83.73 | 13.59 | 22 | 23476 | 413 | 56268156 |
Conjoined twins | 72.79 | 13.59 | 18 | 23480 | 262 | 56268307 |
Torsade de pointes | 70.75 | 13.59 | 51 | 23447 | 12389 | 56256180 |
Labile hypertension | 63.13 | 13.59 | 18 | 23480 | 463 | 56268106 |
Blood pressure increased | 61.10 | 13.59 | 165 | 23333 | 145011 | 56123558 |
Rectal polyp | 59.14 | 13.59 | 21 | 23477 | 1112 | 56267457 |
Maternal exposure during pregnancy | 57.76 | 13.59 | 6 | 23492 | 189547 | 56079022 |
Drug ineffective | 56.08 | 13.59 | 197 | 23301 | 918792 | 55349777 |
Electrocardiogram QT prolonged | 55.14 | 13.59 | 89 | 23409 | 54499 | 56214070 |
Congenital bladder anomaly | 53.79 | 13.59 | 13 | 23485 | 171 | 56268398 |
Intestinal malrotation | 53.44 | 13.59 | 15 | 23483 | 364 | 56268205 |
Urachal abnormality | 53.24 | 13.59 | 13 | 23485 | 179 | 56268390 |
Persistent cloaca | 52.39 | 13.59 | 13 | 23485 | 192 | 56268377 |
Death | 48.21 | 13.59 | 43 | 23455 | 341383 | 55927186 |
Rheumatoid arthritis | 46.31 | 13.59 | 55 | 23443 | 382549 | 55886020 |
Product packaging confusion | 45.22 | 13.59 | 11 | 23487 | 149 | 56268420 |
Off label use | 45 | 13.59 | 104 | 23394 | 556076 | 55712493 |
Change of bowel habit | 43.53 | 13.59 | 20 | 23478 | 2069 | 56266500 |
Sprue-like enteropathy | 43.29 | 13.59 | 14 | 23484 | 556 | 56268013 |
Vessel puncture site haemorrhage | 43.10 | 13.59 | 10 | 23488 | 109 | 56268460 |
Atrial fibrillation | 43.04 | 13.59 | 121 | 23377 | 108776 | 56159793 |
Blood sodium decreased | 41.66 | 13.59 | 49 | 23449 | 22285 | 56246284 |
Intestinal haemorrhage | 41.59 | 13.59 | 23 | 23475 | 3523 | 56265046 |
Sensitisation | 41.14 | 13.59 | 20 | 23478 | 2348 | 56266221 |
Infection | 39.59 | 13.59 | 17 | 23481 | 200189 | 56068380 |
Proctalgia | 39.37 | 13.59 | 26 | 23472 | 5483 | 56263086 |
Left ventricular hypertrophy | 39.25 | 13.59 | 25 | 23473 | 4959 | 56263610 |
Dehydration | 38.92 | 13.59 | 150 | 23348 | 158675 | 56109894 |
Metabolic acidosis | 35.57 | 13.59 | 62 | 23436 | 40392 | 56228177 |
Exposure during pregnancy | 35.30 | 13.59 | 7 | 23491 | 136335 | 56132234 |
Renin increased | 35.14 | 13.59 | 9 | 23489 | 152 | 56268417 |
Infusion related reaction | 35.00 | 13.59 | 22 | 23476 | 208909 | 56059660 |
Fall | 34.97 | 13.59 | 262 | 23236 | 357248 | 55911321 |
Hypertensive angiopathy | 34.67 | 13.59 | 8 | 23490 | 85 | 56268484 |
Alopecia | 34.62 | 13.59 | 43 | 23455 | 293415 | 55975154 |
Nasal mucosal disorder | 33.91 | 13.59 | 11 | 23487 | 441 | 56268128 |
Arthropathy | 33.67 | 13.59 | 21 | 23477 | 200254 | 56068315 |
Croup infectious | 33.45 | 13.59 | 11 | 23487 | 461 | 56268108 |
Systemic lupus erythematosus | 32.97 | 13.59 | 17 | 23481 | 180061 | 56088508 |
Needle issue | 32.73 | 13.59 | 28 | 23470 | 8710 | 56259859 |
Furuncle | 32.54 | 13.59 | 24 | 23474 | 6035 | 56262534 |
Hyperlactacidaemia | 30.94 | 13.59 | 17 | 23481 | 2571 | 56265998 |
Eosinophilia | 30.92 | 13.59 | 40 | 23458 | 20037 | 56248532 |
Central nervous system lupus | 30.78 | 13.59 | 10 | 23488 | 403 | 56268166 |
Injection site discomfort | 30.62 | 13.59 | 20 | 23478 | 4140 | 56264429 |
Glossodynia | 30.05 | 13.59 | 13 | 23485 | 152445 | 56116124 |
Bradycardia | 29.65 | 13.59 | 78 | 23420 | 67426 | 56201143 |
Dysuria | 29.53 | 13.59 | 49 | 23449 | 30680 | 56237889 |
Contraindicated product administered | 29.34 | 13.59 | 21 | 23477 | 186265 | 56082304 |
Orthostatic hypotension | 29.34 | 13.59 | 51 | 23447 | 33148 | 56235421 |
Duodenal ulcer | 29.01 | 13.59 | 24 | 23474 | 7131 | 56261438 |
Urine odour abnormal | 28.73 | 13.59 | 22 | 23476 | 5852 | 56262717 |
Product dose omission issue | 28.60 | 13.59 | 26 | 23472 | 204727 | 56063842 |
Treatment failure | 28.45 | 13.59 | 18 | 23480 | 170374 | 56098195 |
Swelling | 28.40 | 13.59 | 35 | 23463 | 239736 | 56028833 |
Angioedema | 28.29 | 13.59 | 57 | 23441 | 41396 | 56227173 |
Lactic acidosis | 28.29 | 13.59 | 52 | 23446 | 35294 | 56233275 |
Hypotension | 27.59 | 13.59 | 189 | 23309 | 250319 | 56018250 |
Hepatic enzyme increased | 27.41 | 13.59 | 19 | 23479 | 171365 | 56097204 |
Postoperative wound infection | 27.31 | 13.59 | 26 | 23472 | 9287 | 56259282 |
Dyslipidaemia | 27.21 | 13.59 | 22 | 23476 | 6331 | 56262238 |
Gravitational oedema | 26.86 | 13.59 | 12 | 23486 | 1163 | 56267406 |
Diabetic metabolic decompensation | 26.67 | 13.59 | 13 | 23485 | 1535 | 56267034 |
Urine abnormality | 26.18 | 13.59 | 22 | 23476 | 6677 | 56261892 |
Hypouricaemia | 25.90 | 13.59 | 7 | 23491 | 147 | 56268422 |
Blood electrolytes abnormal | 25.56 | 13.59 | 11 | 23487 | 975 | 56267594 |
Frustration tolerance decreased | 25.11 | 13.59 | 21 | 23477 | 6332 | 56262237 |
Discomfort | 25.04 | 13.59 | 14 | 23484 | 141747 | 56126822 |
Bladder disorder | 24.67 | 13.59 | 23 | 23475 | 8001 | 56260568 |
Dizziness | 24.43 | 13.59 | 252 | 23246 | 375888 | 55892681 |
Polyp | 24.23 | 13.59 | 20 | 23478 | 5922 | 56262647 |
Convulsive threshold lowered | 24.19 | 13.59 | 8 | 23490 | 341 | 56268228 |
Mucocutaneous haemorrhage | 24.03 | 13.59 | 6 | 23492 | 91 | 56268478 |
Circulatory collapse | 23.89 | 13.59 | 36 | 23462 | 20767 | 56247802 |
Abdominal discomfort | 23.87 | 13.59 | 50 | 23448 | 277224 | 55991345 |
Mass | 23.66 | 13.59 | 28 | 23470 | 12811 | 56255758 |
Peripheral coldness | 23.66 | 13.59 | 26 | 23472 | 10985 | 56257584 |
Presyncope | 23.52 | 13.59 | 40 | 23458 | 25542 | 56243027 |
Platelet dysfunction | 23.39 | 13.59 | 6 | 23492 | 102 | 56268467 |
Sinusitis | 23.23 | 13.59 | 29 | 23469 | 197552 | 56071017 |
Urinary incontinence | 23.02 | 13.59 | 43 | 23455 | 29542 | 56239027 |
Renal impairment | 22.92 | 13.59 | 80 | 23418 | 80633 | 56187936 |
Paramnesia | 22.74 | 13.59 | 4 | 23494 | 8 | 56268561 |
Wound | 22.71 | 13.59 | 15 | 23483 | 138789 | 56129780 |
Blood pressure inadequately controlled | 22.25 | 13.59 | 17 | 23481 | 4507 | 56264062 |
Ischaemic stroke | 22.04 | 13.59 | 31 | 23467 | 16811 | 56251758 |
Vomiting | 21.94 | 13.59 | 310 | 23188 | 497918 | 55770651 |
Renal artery stenosis | 21.86 | 13.59 | 12 | 23486 | 1811 | 56266758 |
Oliguria | 21.83 | 13.59 | 22 | 23476 | 8418 | 56260151 |
Urine albumin/creatinine ratio increased | 21.79 | 13.59 | 7 | 23491 | 272 | 56268297 |
Glomerular filtration rate decreased | 21.27 | 13.59 | 26 | 23472 | 12303 | 56256266 |
Rhabdomyolysis | 21.02 | 13.59 | 50 | 23448 | 40608 | 56227961 |
Syncope | 20.86 | 13.59 | 95 | 23403 | 108104 | 56160465 |
Impaired work ability | 20.84 | 13.59 | 28 | 23470 | 14544 | 56254025 |
Psychomotor retardation | 20.76 | 13.59 | 15 | 23483 | 3654 | 56264915 |
Glycosylated haemoglobin increased | 20.00 | 13.59 | 24 | 23474 | 11141 | 56257428 |
Hypovolaemic shock | 19.68 | 13.59 | 17 | 23481 | 5356 | 56263213 |
Fatigue | 19.58 | 13.59 | 223 | 23275 | 788329 | 55480240 |
Malaise | 19.56 | 13.59 | 237 | 23261 | 367623 | 55900946 |
Retinal detachment | 19.50 | 13.59 | 17 | 23481 | 5424 | 56263145 |
Impaired healing | 19.48 | 13.59 | 6 | 23492 | 86835 | 56181734 |
Iron deficiency | 19.37 | 13.59 | 18 | 23480 | 6238 | 56262331 |
Labelled drug-drug interaction medication error | 19.29 | 13.59 | 24 | 23474 | 11562 | 56257007 |
Spinal pain | 18.80 | 13.59 | 24 | 23474 | 11860 | 56256709 |
Blood pressure systolic increased | 18.76 | 13.59 | 48 | 23450 | 40788 | 56227781 |
Rash | 18.62 | 13.59 | 125 | 23373 | 492922 | 55775647 |
Pyelonephritis acute | 18.56 | 13.59 | 15 | 23483 | 4314 | 56264255 |
Drug abuse | 18.51 | 13.59 | 3 | 23495 | 67607 | 56200962 |
Myalgia | 18.50 | 13.59 | 106 | 23392 | 131919 | 56136650 |
Butterfly rash | 18.30 | 13.59 | 10 | 23488 | 1496 | 56267073 |
Hypoglycaemia | 18.22 | 13.59 | 58 | 23440 | 55757 | 56212812 |
Vulvovaginal inflammation | 18.11 | 13.59 | 8 | 23490 | 755 | 56267814 |
Heart rate decreased | 18.04 | 13.59 | 47 | 23451 | 40380 | 56228189 |
Jaundice | 17.99 | 13.59 | 37 | 23461 | 27257 | 56241312 |
Leukocyturia | 17.97 | 13.59 | 9 | 23489 | 1126 | 56267443 |
Failure to suspend medication | 17.83 | 13.59 | 4 | 23494 | 37 | 56268532 |
Hypotonia | 17.80 | 13.59 | 20 | 23478 | 8657 | 56259912 |
Migraine | 17.74 | 13.59 | 7 | 23491 | 86790 | 56181779 |
Stevens-Johnson syndrome | 17.70 | 13.59 | 33 | 23465 | 22630 | 56245939 |
Anuria | 17.44 | 13.59 | 23 | 23475 | 11737 | 56256832 |
Thyroid disorder | 17.27 | 13.59 | 25 | 23473 | 13913 | 56254656 |
Hepatitis D | 17.21 | 13.59 | 4 | 23494 | 44 | 56268525 |
Blood urea increased | 17.11 | 13.59 | 34 | 23464 | 24439 | 56244130 |
Metabolic alkalosis | 16.92 | 13.59 | 12 | 23486 | 2839 | 56265730 |
Serratia infection | 16.89 | 13.59 | 8 | 23490 | 887 | 56267682 |
Protrusion tongue | 16.85 | 13.59 | 6 | 23492 | 320 | 56268249 |
Blood glucose increased | 16.79 | 13.59 | 69 | 23429 | 75082 | 56193487 |
Inclusion body myositis | 16.74 | 13.59 | 3 | 23495 | 7 | 56268562 |
Fear of eating | 16.39 | 13.59 | 6 | 23492 | 347 | 56268222 |
Intracranial haematoma | 16.26 | 13.59 | 6 | 23492 | 355 | 56268214 |
Blood creatine phosphokinase increased | 16.24 | 13.59 | 36 | 23462 | 27916 | 56240653 |
Haematoma | 16.14 | 13.59 | 39 | 23459 | 31980 | 56236589 |
Drug hypersensitivity | 15.97 | 13.59 | 60 | 23438 | 275145 | 55993424 |
Arrhythmia | 15.87 | 13.59 | 41 | 23457 | 35042 | 56233527 |
Urine output decreased | 15.86 | 13.59 | 21 | 23477 | 10756 | 56257813 |
Hypocalciuria | 15.73 | 13.59 | 3 | 23495 | 11 | 56268558 |
Lung neoplasm malignant | 15.73 | 13.59 | 27 | 23471 | 17369 | 56251200 |
Poor dental condition | 15.56 | 13.59 | 6 | 23492 | 401 | 56268168 |
Weight increased | 15.43 | 13.59 | 47 | 23451 | 229656 | 56038913 |
Hospitalisation | 15.41 | 13.59 | 6 | 23492 | 74994 | 56193575 |
Normocytic anaemia | 15.08 | 13.59 | 9 | 23489 | 1590 | 56266979 |
Therapeutic product effect decreased | 15.04 | 13.59 | 30 | 23468 | 169422 | 56099147 |
Lupus nephritis | 15.02 | 13.59 | 11 | 23487 | 2736 | 56265833 |
Blood pressure abnormal | 14.79 | 13.59 | 23 | 23475 | 13637 | 56254932 |
Pain | 14.73 | 13.59 | 192 | 23306 | 662992 | 55605577 |
Injection site erythema | 14.63 | 13.59 | 7 | 23491 | 77441 | 56191128 |
Exostosis | 14.58 | 13.59 | 24 | 23474 | 14919 | 56253650 |
Lower respiratory tract infection | 14.39 | 13.59 | 16 | 23482 | 114778 | 56153791 |
Red blood cell sedimentation rate abnormal | 14.35 | 13.59 | 27 | 23471 | 18646 | 56249923 |
Neglect of personal appearance | 14.25 | 13.59 | 4 | 23494 | 97 | 56268472 |
Lymphocytic infiltration | 14.14 | 13.59 | 7 | 23491 | 855 | 56267714 |
Ventricular fibrillation | 14.09 | 13.59 | 20 | 23478 | 10932 | 56257637 |
Tubulointerstitial nephritis | 13.94 | 13.59 | 25 | 23473 | 16640 | 56251929 |
Nail injury | 13.93 | 13.59 | 6 | 23492 | 533 | 56268036 |
Oedema peripheral | 13.70 | 13.59 | 120 | 23378 | 171134 | 56097435 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyponatraemia | 281.41 | 14.25 | 259 | 15786 | 73540 | 31607759 |
Hypokalaemia | 223.67 | 14.25 | 198 | 15847 | 53376 | 31627923 |
Acute kidney injury | 115.27 | 14.25 | 356 | 15689 | 279358 | 31401941 |
Hypomagnesaemia | 84.51 | 14.25 | 73 | 15972 | 18985 | 31662314 |
Death | 75.10 | 14.25 | 45 | 16000 | 360524 | 31320775 |
Drug interaction | 71.76 | 14.25 | 250 | 15795 | 208293 | 31473006 |
Hypoosmolar state | 44.42 | 14.25 | 10 | 16035 | 76 | 31681223 |
Bradycardia | 41.00 | 14.25 | 101 | 15944 | 69226 | 31612073 |
Mucosal dryness | 37.28 | 14.25 | 16 | 16029 | 1159 | 31680140 |
Hyperkalaemia | 37.25 | 14.25 | 93 | 15952 | 64258 | 31617041 |
Syncope | 37.22 | 14.25 | 111 | 15934 | 85071 | 31596228 |
Completed suicide | 35.17 | 14.25 | 3 | 16042 | 91511 | 31589788 |
Lactic acidosis | 34.91 | 14.25 | 60 | 15985 | 31877 | 31649422 |
Left atrial dilatation | 34.07 | 14.25 | 17 | 16028 | 1738 | 31679561 |
Postictal paralysis | 33.87 | 14.25 | 10 | 16035 | 239 | 31681060 |
Drug abuse | 33.39 | 14.25 | 3 | 16042 | 87755 | 31593544 |
Drug dispensed to wrong patient | 31.21 | 14.25 | 11 | 16034 | 468 | 31680831 |
Atrial fibrillation | 31.17 | 14.25 | 127 | 15918 | 113656 | 31567643 |
Drug ineffective | 30.42 | 14.25 | 101 | 15944 | 395472 | 31285827 |
Herbal interaction | 29.99 | 14.25 | 10 | 16035 | 359 | 31680940 |
Haematocrit increased | 29.98 | 14.25 | 16 | 16029 | 1881 | 31679418 |
Hypotension | 29.09 | 14.25 | 190 | 15855 | 204428 | 31476871 |
Obesity | 27.58 | 14.25 | 31 | 16014 | 11069 | 31670230 |
Oedema peripheral | 27.28 | 14.25 | 119 | 15926 | 109720 | 31571579 |
Consciousness fluctuating | 25.29 | 14.25 | 12 | 16033 | 1099 | 31680200 |
Off label use | 25.10 | 14.25 | 91 | 15954 | 347183 | 31334116 |
Haemoglobin increased | 24.95 | 14.25 | 17 | 16028 | 3109 | 31678190 |
Renal artery arteriosclerosis | 24.53 | 14.25 | 5 | 16040 | 22 | 31681277 |
Tumour invasion | 24 | 14.25 | 8 | 16037 | 287 | 31681012 |
Gastrointestinal ischaemia | 23.64 | 14.25 | 7 | 16038 | 169 | 31681130 |
Dizziness | 23.63 | 14.25 | 177 | 15868 | 198970 | 31482329 |
Cholestasis | 23.42 | 14.25 | 44 | 16001 | 25031 | 31656268 |
Polyuria | 23.32 | 14.25 | 24 | 16021 | 7759 | 31673540 |
Myalgia | 22.55 | 14.25 | 88 | 15957 | 77170 | 31604129 |
Electrolyte imbalance | 22.14 | 14.25 | 29 | 16016 | 12119 | 31669180 |
Tachyarrhythmia | 22.10 | 14.25 | 16 | 16029 | 3223 | 31678076 |
Inappropriate antidiuretic hormone secretion | 22.04 | 14.25 | 28 | 16017 | 11359 | 31669940 |
Pancreatic neoplasm | 21.64 | 14.25 | 10 | 16035 | 863 | 31680436 |
Nail pitting | 20.98 | 14.25 | 7 | 16038 | 252 | 31681047 |
Renal artery restenosis | 20.82 | 14.25 | 4 | 16041 | 12 | 31681287 |
Febrile neutropenia | 20.36 | 14.25 | 19 | 16026 | 121830 | 31559469 |
Dyspnoea exertional | 20.26 | 14.25 | 54 | 15991 | 38783 | 31642516 |
Lip swelling | 20.06 | 14.25 | 29 | 16016 | 13294 | 31668005 |
Angioedema | 19.87 | 14.25 | 49 | 15996 | 33569 | 31647730 |
Bundle branch block right | 19.86 | 14.25 | 21 | 16024 | 7003 | 31674296 |
Onychophagia | 19.86 | 14.25 | 5 | 16040 | 64 | 31681235 |
Presyncope | 19.52 | 14.25 | 33 | 16012 | 17295 | 31664004 |
Angular cheilitis | 19.15 | 14.25 | 6 | 16039 | 176 | 31681123 |
Hypoparathyroidism | 18.99 | 14.25 | 8 | 16037 | 553 | 31680746 |
Ventricular flutter | 18.94 | 14.25 | 5 | 16040 | 78 | 31681221 |
Renal pain | 18.88 | 14.25 | 14 | 16031 | 2925 | 31678374 |
Glycosylated haemoglobin decreased | 18.37 | 14.25 | 7 | 16038 | 372 | 31680927 |
Oedema genital | 18.16 | 14.25 | 7 | 16038 | 384 | 31680915 |
Hepatic ischaemia | 18.14 | 14.25 | 7 | 16038 | 385 | 31680914 |
Tubulointerstitial nephritis | 17.95 | 14.25 | 33 | 16012 | 18463 | 31662836 |
Neutrophilia | 17.59 | 14.25 | 15 | 16030 | 3828 | 31677471 |
Skin disorder | 17.43 | 14.25 | 26 | 16019 | 12255 | 31669044 |
Arrhythmia | 17.26 | 14.25 | 46 | 15999 | 33031 | 31648268 |
Hypovolaemia | 16.86 | 14.25 | 21 | 16024 | 8351 | 31672948 |
Electrocardiogram T wave abnormal | 16.84 | 14.25 | 10 | 16035 | 1443 | 31679856 |
Wheezing | 16.75 | 14.25 | 48 | 15997 | 35938 | 31645361 |
Arterial stenosis | 16.30 | 14.25 | 9 | 16036 | 1132 | 31680167 |
Gingival hypoplasia | 16.16 | 14.25 | 3 | 16042 | 7 | 31681292 |
Thrombocytosis | 15.96 | 14.25 | 14 | 16031 | 3709 | 31677590 |
Atrioventricular block | 15.78 | 14.25 | 19 | 16026 | 7296 | 31674003 |
External ear pain | 15.61 | 14.25 | 3 | 16042 | 9 | 31681290 |
Metastases to peritoneum | 15.61 | 14.25 | 10 | 16035 | 1650 | 31679649 |
Pneumonia | 15.43 | 14.25 | 103 | 15942 | 335209 | 31346090 |
Nocturia | 15.23 | 14.25 | 21 | 16024 | 9214 | 31672085 |
Choroidal effusion | 15.17 | 14.25 | 5 | 16040 | 173 | 31681126 |
Hypocalcaemia | 15.13 | 14.25 | 34 | 16011 | 21944 | 31659355 |
Plasma cell myeloma | 14.91 | 14.25 | 5 | 16040 | 56526 | 31624773 |
Erectile dysfunction | 14.65 | 14.25 | 31 | 16014 | 19204 | 31662095 |
Polydipsia | 14.56 | 14.25 | 13 | 16032 | 3527 | 31677772 |
Face oedema | 14.39 | 14.25 | 22 | 16023 | 10594 | 31670705 |
Ephelides | 14.27 | 14.25 | 4 | 16041 | 79 | 31681220 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyponatraemia | 1376.57 | 12.12 | 917 | 35938 | 159170 | 70732419 |
Hypokalaemia | 695.06 | 12.12 | 562 | 36293 | 130626 | 70760963 |
Acute kidney injury | 307.64 | 12.12 | 726 | 36129 | 473898 | 70417691 |
Hypomagnesaemia | 180.93 | 12.12 | 158 | 36697 | 40606 | 70850983 |
Drug interaction | 158.39 | 12.12 | 496 | 36359 | 380945 | 70510644 |
Inappropriate antidiuretic hormone secretion | 136.31 | 12.12 | 106 | 36749 | 23170 | 70868419 |
Confusional state | 113.45 | 12.12 | 365 | 36490 | 284033 | 70607556 |
Hypochloraemia | 111.45 | 12.12 | 42 | 36813 | 2109 | 70889480 |
Death | 99.71 | 12.12 | 72 | 36783 | 509989 | 70381600 |
Completed suicide | 97.39 | 12.12 | 5 | 36850 | 227130 | 70664459 |
Atrial fibrillation | 80.23 | 12.12 | 244 | 36611 | 184104 | 70707485 |
Burning mouth syndrome | 79.89 | 12.12 | 23 | 36832 | 488 | 70891101 |
Hyponatraemic seizure | 79.40 | 12.12 | 23 | 36832 | 499 | 70891090 |
Off label use | 74.03 | 12.12 | 174 | 36681 | 742886 | 70148703 |
Torsade de pointes | 70.05 | 12.12 | 65 | 36790 | 18051 | 70873538 |
Drug ineffective | 62.02 | 12.12 | 265 | 36590 | 939487 | 69952102 |
Bradycardia | 58.99 | 12.12 | 170 | 36685 | 124445 | 70767144 |
Labile hypertension | 57.25 | 12.12 | 18 | 36837 | 520 | 70891069 |
Lactic acidosis | 56.09 | 12.12 | 112 | 36743 | 64912 | 70826677 |
Drug abuse | 55.31 | 12.12 | 6 | 36849 | 147250 | 70744339 |
Blood pressure increased | 52.16 | 12.12 | 215 | 36640 | 188302 | 70703287 |
Electrocardiogram QT prolonged | 51.79 | 12.12 | 126 | 36729 | 83391 | 70808198 |
Syncope | 50.67 | 12.12 | 195 | 36660 | 165514 | 70726075 |
Rectal polyp | 49.23 | 12.12 | 21 | 36834 | 1459 | 70890130 |
Maternal exposure during pregnancy | 47.99 | 12.12 | 3 | 36852 | 115342 | 70776247 |
Blood sodium decreased | 46.08 | 12.12 | 68 | 36787 | 30930 | 70860659 |
Dizziness | 42.88 | 12.12 | 398 | 36457 | 463743 | 70427846 |
Presyncope | 41.71 | 12.12 | 72 | 36783 | 37366 | 70854223 |
Hypotension | 41.58 | 12.12 | 355 | 36500 | 404026 | 70487563 |
Angioedema | 40.77 | 12.12 | 100 | 36755 | 66510 | 70825079 |
Febrile neutropenia | 39.61 | 12.12 | 29 | 36826 | 204289 | 70687300 |
Rheumatoid arthritis | 38.98 | 12.12 | 57 | 36798 | 291748 | 70599841 |
Product packaging confusion | 38.82 | 12.12 | 11 | 36844 | 220 | 70891369 |
Renin increased | 38.77 | 12.12 | 11 | 36844 | 221 | 70891368 |
Myalgia | 38.46 | 12.12 | 181 | 36674 | 167711 | 70723878 |
Change of bowel habit | 37.68 | 12.12 | 21 | 36834 | 2618 | 70888971 |
Infusion related reaction | 37.06 | 12.12 | 29 | 36826 | 197505 | 70694084 |
Hypoosmolar state | 36.61 | 12.12 | 11 | 36844 | 272 | 70891317 |
Vessel puncture site haemorrhage | 36.44 | 12.12 | 10 | 36845 | 177 | 70891412 |
Left ventricular hypertrophy | 36.37 | 12.12 | 35 | 36820 | 10167 | 70881422 |
Sensitisation | 36.19 | 12.12 | 20 | 36835 | 2453 | 70889136 |
Treatment failure | 35.83 | 12.12 | 15 | 36840 | 144127 | 70747462 |
Infection | 34.67 | 12.12 | 35 | 36820 | 210750 | 70680839 |
Needle issue | 34.38 | 12.12 | 35 | 36820 | 10880 | 70880709 |
Nasal mucosal disorder | 34.04 | 12.12 | 11 | 36844 | 348 | 70891241 |
Metabolic acidosis | 33.79 | 12.12 | 100 | 36755 | 74246 | 70817343 |
Toxicity to various agents | 33.68 | 12.12 | 95 | 36760 | 382077 | 70509512 |
Pericarditis | 32.98 | 12.12 | 3 | 36852 | 84702 | 70806887 |
Pemphigus | 32.17 | 12.12 | 3 | 36852 | 83033 | 70808556 |
Hypertensive angiopathy | 31.74 | 12.12 | 8 | 36847 | 100 | 70891489 |
Oedema peripheral | 31.69 | 12.12 | 215 | 36640 | 227876 | 70663713 |
Sprue-like enteropathy | 31.23 | 12.12 | 14 | 36841 | 1096 | 70890493 |
Orthostatic hypotension | 30.94 | 12.12 | 77 | 36778 | 51666 | 70839923 |
Sinusitis | 30.29 | 12.12 | 26 | 36829 | 169169 | 70722420 |
Postictal paralysis | 30.06 | 12.12 | 10 | 36845 | 347 | 70891242 |
Hyperkalaemia | 29.79 | 12.12 | 122 | 36733 | 106469 | 70785120 |
Blood pressure inadequately controlled | 29.59 | 12.12 | 24 | 36831 | 5568 | 70886021 |
Exposure during pregnancy | 29.55 | 12.12 | 5 | 36850 | 87712 | 70803877 |
Drug dispensed to wrong patient | 28.91 | 12.12 | 11 | 36844 | 567 | 70891022 |
Central nervous system lupus | 28.90 | 12.12 | 10 | 36845 | 392 | 70891197 |
Proctalgia | 28.46 | 12.12 | 28 | 36827 | 8355 | 70883234 |
Fall | 28.45 | 12.12 | 354 | 36501 | 443742 | 70447847 |
Dehydration | 28.40 | 12.12 | 208 | 36647 | 225934 | 70665655 |
Croup infectious | 28.13 | 12.12 | 11 | 36844 | 611 | 70890978 |
Product dose omission issue | 27.56 | 12.12 | 44 | 36811 | 217424 | 70674165 |
Herbal interaction | 27.37 | 12.12 | 10 | 36845 | 460 | 70891129 |
Cholestasis | 27.33 | 12.12 | 70 | 36785 | 47802 | 70843787 |
Arrhythmia | 26.94 | 12.12 | 77 | 36778 | 56066 | 70835523 |
Metabolic alkalosis | 26.85 | 12.12 | 20 | 36835 | 4096 | 70887493 |
Mucosal dryness | 26.46 | 12.12 | 18 | 36837 | 3198 | 70888391 |
Dyslipidaemia | 26.40 | 12.12 | 29 | 36826 | 9831 | 70881758 |
Intestinal haemorrhage | 26.02 | 12.12 | 23 | 36832 | 5997 | 70885592 |
Swelling | 25.98 | 12.12 | 36 | 36819 | 188503 | 70703086 |
Left atrial dilatation | 25.98 | 12.12 | 17 | 36838 | 2832 | 70888757 |
Furuncle | 24.93 | 12.12 | 24 | 36831 | 6974 | 70884615 |
Diabetic metabolic decompensation | 24.92 | 12.12 | 17 | 36838 | 3035 | 70888554 |
Injection site discomfort | 24.62 | 12.12 | 20 | 36835 | 4649 | 70886940 |
Glycosylated haemoglobin increased | 24.20 | 12.12 | 37 | 36818 | 17354 | 70874235 |
Angular cheilitis | 24.18 | 12.12 | 10 | 36845 | 643 | 70890946 |
Electrolyte imbalance | 24.04 | 12.12 | 47 | 36808 | 26814 | 70864775 |
Hypocalcaemia | 23.97 | 12.12 | 64 | 36791 | 44795 | 70846794 |
Tubulointerstitial nephritis | 23.89 | 12.12 | 53 | 36802 | 33023 | 70858566 |
Renal artery stenosis | 23.79 | 12.12 | 17 | 36838 | 3267 | 70888322 |
Circulatory collapse | 23.58 | 12.12 | 55 | 36800 | 35419 | 70856170 |
Urine odour abnormal | 23.28 | 12.12 | 21 | 36834 | 5622 | 70885967 |
Pain | 23.21 | 12.12 | 212 | 36643 | 628604 | 70262985 |
Blood pressure abnormal | 23.01 | 12.12 | 34 | 36821 | 15480 | 70876109 |
Plasma cell myeloma | 22.91 | 12.12 | 5 | 36850 | 73196 | 70818393 |
Contraindicated product administered | 22.53 | 12.12 | 22 | 36833 | 134590 | 70756999 |
Atrioventricular block | 22.06 | 12.12 | 30 | 36825 | 12658 | 70878931 |
Tumour invasion | 22.04 | 12.12 | 8 | 36847 | 361 | 70891228 |
Frustration tolerance decreased | 21.87 | 12.12 | 22 | 36833 | 6743 | 70884846 |
Ischaemic stroke | 21.83 | 12.12 | 49 | 36806 | 30771 | 70860818 |
Jaundice | 21.45 | 12.12 | 66 | 36789 | 50042 | 70841547 |
Nocturia | 21.43 | 12.12 | 29 | 36826 | 12175 | 70879414 |
Gastrointestinal ischaemia | 21.32 | 12.12 | 8 | 36847 | 397 | 70891192 |
Dysuria | 21.19 | 12.12 | 62 | 36793 | 45732 | 70845857 |
Hyperlactacidaemia | 21.17 | 12.12 | 19 | 36836 | 5053 | 70886536 |
Helicobacter test positive | 21.04 | 12.12 | 11 | 36844 | 1208 | 70890381 |
Eosinophilia | 21.02 | 12.12 | 57 | 36798 | 40262 | 70851327 |
Urine abnormality | 20.90 | 12.12 | 23 | 36832 | 7815 | 70883774 |
Injection site erythema | 20.85 | 12.12 | 6 | 36849 | 72918 | 70818671 |
Renal artery restenosis | 20.71 | 12.12 | 4 | 36851 | 12 | 70891577 |
Renal failure | 20.45 | 12.12 | 168 | 36687 | 188902 | 70702687 |
Drug hypersensitivity | 20.43 | 12.12 | 69 | 36786 | 262390 | 70629199 |
Malaise | 20.42 | 12.12 | 327 | 36528 | 432605 | 70458984 |
Osmotic demyelination syndrome | 20.39 | 12.12 | 11 | 36844 | 1286 | 70890303 |
Mental status changes | 20.38 | 12.12 | 4 | 36851 | 63097 | 70828492 |
Arthropathy | 20.32 | 12.12 | 29 | 36826 | 150028 | 70741561 |
Rhabdomyolysis | 20.30 | 12.12 | 101 | 36754 | 95659 | 70795930 |
Bundle branch block left | 20.26 | 12.12 | 26 | 36829 | 10373 | 70881216 |
Rash maculo-papular | 20.19 | 12.12 | 65 | 36790 | 50480 | 70841109 |
Alopecia | 20.04 | 12.12 | 46 | 36809 | 198444 | 70693145 |
Haematocrit increased | 19.90 | 12.12 | 16 | 36839 | 3666 | 70887923 |
Gravitational oedema | 19.86 | 12.12 | 12 | 36843 | 1740 | 70889849 |
Bladder disorder | 19.84 | 12.12 | 23 | 36832 | 8266 | 70883323 |
Consciousness fluctuating | 19.71 | 12.12 | 12 | 36843 | 1764 | 70889825 |
Hypoglycaemia | 19.63 | 12.12 | 99 | 36756 | 94265 | 70797324 |
Hypovolaemic shock | 19.41 | 12.12 | 26 | 36829 | 10811 | 70880778 |
Stomatitis | 19.29 | 12.12 | 23 | 36832 | 128488 | 70763101 |
Platelet count decreased | 19.06 | 12.12 | 40 | 36815 | 178182 | 70713407 |
Swollen tongue | 18.94 | 12.12 | 52 | 36803 | 36994 | 70854595 |
Nail pitting | 18.87 | 12.12 | 7 | 36848 | 336 | 70891253 |
Lip swelling | 18.62 | 12.12 | 49 | 36806 | 34005 | 70857584 |
Mucocutaneous haemorrhage | 18.56 | 12.12 | 6 | 36849 | 190 | 70891399 |
Postoperative wound infection | 18.50 | 12.12 | 26 | 36829 | 11312 | 70880277 |
Paramnesia | 18.34 | 12.12 | 4 | 36851 | 25 | 70891564 |
Fatigue | 18.29 | 12.12 | 310 | 36545 | 824009 | 70067580 |
Glomerular filtration rate decreased | 18.19 | 12.12 | 36 | 36819 | 20720 | 70870869 |
Hypovolaemia | 18.13 | 12.12 | 31 | 36824 | 15962 | 70875627 |
Mass | 18.08 | 12.12 | 31 | 36824 | 15995 | 70875594 |
Psychomotor retardation | 17.72 | 12.12 | 18 | 36837 | 5580 | 70886009 |
Ventricular flutter | 17.69 | 12.12 | 5 | 36850 | 99 | 70891490 |
Haemoglobin increased | 17.67 | 12.12 | 18 | 36837 | 5597 | 70885992 |
Hypouricaemia | 17.45 | 12.12 | 7 | 36848 | 416 | 70891173 |
Blood glucose increased | 17.34 | 12.12 | 102 | 36753 | 102880 | 70788709 |
Polyp | 17.34 | 12.12 | 20 | 36835 | 7150 | 70884439 |
Renal impairment | 17.26 | 12.12 | 131 | 36724 | 143806 | 70747783 |
Pneumonia | 17.13 | 12.12 | 213 | 36642 | 596019 | 70295570 |
Renal artery arteriosclerosis | 17.06 | 12.12 | 4 | 36851 | 36 | 70891553 |
Urine albumin/creatinine ratio increased | 16.98 | 12.12 | 7 | 36848 | 446 | 70891143 |
Arterial stenosis | 16.98 | 12.12 | 10 | 36845 | 1383 | 70890206 |
Blood electrolytes abnormal | 16.97 | 12.12 | 11 | 36844 | 1803 | 70889786 |
Disease progression | 16.89 | 12.12 | 35 | 36820 | 156637 | 70734952 |
Hypertension | 16.83 | 12.12 | 231 | 36624 | 295802 | 70595787 |
Discomfort | 16.77 | 12.12 | 18 | 36837 | 105418 | 70786171 |
Butterfly rash | 16.74 | 12.12 | 10 | 36845 | 1420 | 70890169 |
Pancreatic neoplasm | 16.66 | 12.12 | 10 | 36845 | 1433 | 70890156 |
Pyrexia | 16.64 | 12.12 | 219 | 36636 | 606733 | 70284856 |
Oedema genital | 16.59 | 12.12 | 7 | 36848 | 473 | 70891116 |
Impaired healing | 16.54 | 12.12 | 9 | 36846 | 74365 | 70817224 |
Injection site reaction | 16.44 | 12.12 | 3 | 36852 | 49849 | 70841740 |
Therapeutic product effect decreased | 16.24 | 12.12 | 31 | 36824 | 142987 | 70748602 |
Gingival hypoplasia | 16.08 | 12.12 | 3 | 36852 | 7 | 70891582 |
Stevens-Johnson syndrome | 16.03 | 12.12 | 48 | 36807 | 35859 | 70855730 |
Product use in unapproved indication | 15.83 | 12.12 | 55 | 36800 | 207423 | 70684166 |
Wrong technique in product usage process | 15.74 | 12.12 | 8 | 36847 | 68690 | 70822899 |
Migraine | 15.69 | 12.12 | 9 | 36846 | 72229 | 70819360 |
Systemic lupus erythematosus | 15.54 | 12.12 | 18 | 36837 | 101884 | 70789705 |
Bundle branch block right | 15.37 | 12.12 | 23 | 36832 | 10587 | 70881002 |
Hepatic enzyme increased | 15.35 | 12.12 | 37 | 36818 | 156953 | 70734636 |
Anaemia megaloblastic | 15.32 | 12.12 | 7 | 36848 | 573 | 70891016 |
Ventricular extrasystoles | 15.24 | 12.12 | 31 | 36824 | 18195 | 70873394 |
White blood cell count decreased | 15.18 | 12.12 | 42 | 36813 | 170099 | 70721490 |
Convulsive threshold lowered | 14.99 | 12.12 | 8 | 36847 | 916 | 70890673 |
Diabetes mellitus inadequate control | 14.93 | 12.12 | 35 | 36820 | 22610 | 70868979 |
Glucose tolerance impaired | 14.83 | 12.12 | 18 | 36837 | 6788 | 70884801 |
Thyroid disorder | 14.71 | 12.12 | 25 | 36830 | 12807 | 70878782 |
Spinal pain | 14.71 | 12.12 | 26 | 36829 | 13744 | 70877845 |
Retinal detachment | 14.69 | 12.12 | 20 | 36835 | 8447 | 70883142 |
Glycosylated haemoglobin decreased | 14.52 | 12.12 | 7 | 36848 | 647 | 70890942 |
Inclusion body myositis | 14.49 | 12.12 | 3 | 36852 | 14 | 70891575 |
Platelet dysfunction | 14.41 | 12.12 | 6 | 36849 | 392 | 70891197 |
Gingival hypertrophy | 14.41 | 12.12 | 12 | 36843 | 2886 | 70888703 |
Hospitalisation | 14.39 | 12.12 | 13 | 36842 | 82555 | 70809034 |
Pemphigoid | 14.37 | 12.12 | 26 | 36829 | 13996 | 70877593 |
External ear pain | 14.32 | 12.12 | 3 | 36852 | 15 | 70891574 |
Hypersensitivity | 14.32 | 12.12 | 66 | 36789 | 229746 | 70661843 |
Protrusion tongue | 14.31 | 12.12 | 6 | 36849 | 399 | 70891190 |
Hypoparathyroidism | 14.29 | 12.12 | 8 | 36847 | 1006 | 70890583 |
Medication error | 14.24 | 12.12 | 63 | 36792 | 56849 | 70834740 |
Tachyarrhythmia | 14.10 | 12.12 | 17 | 36838 | 6365 | 70885224 |
Chronic gastritis | 14.04 | 12.12 | 13 | 36842 | 3600 | 70887989 |
Fear of eating | 13.99 | 12.12 | 6 | 36849 | 422 | 70891167 |
Hepatitis D | 13.89 | 12.12 | 4 | 36851 | 85 | 70891504 |
Proteinuria | 13.81 | 12.12 | 40 | 36815 | 29334 | 70862255 |
Ventricular tachycardia | 13.79 | 12.12 | 46 | 36809 | 36377 | 70855212 |
Peripheral coldness | 13.74 | 12.12 | 26 | 36829 | 14474 | 70877115 |
Product use issue | 13.52 | 12.12 | 48 | 36807 | 179889 | 70711700 |
Blood glucose decreased | 13.45 | 12.12 | 35 | 36820 | 24124 | 70867465 |
Wound | 13.44 | 12.12 | 19 | 36836 | 98713 | 70792876 |
Diabetes mellitus | 13.32 | 12.12 | 73 | 36782 | 71751 | 70819838 |
Polydipsia | 13.31 | 12.12 | 16 | 36839 | 5972 | 70885617 |
Vulvovaginal inflammation | 13.19 | 12.12 | 6 | 36849 | 486 | 70891103 |
Pain in jaw | 13.18 | 12.12 | 3 | 36852 | 42666 | 70848923 |
Abdominal discomfort | 13.16 | 12.12 | 62 | 36793 | 214596 | 70676993 |
Folliculitis | 13.13 | 12.12 | 3 | 36852 | 42567 | 70849022 |
Ill-defined disorder | 13.11 | 12.12 | 6 | 36849 | 54735 | 70836854 |
Leukocyturia | 13.08 | 12.12 | 9 | 36846 | 1628 | 70889961 |
Oliguria | 13.06 | 12.12 | 26 | 36829 | 15025 | 70876564 |
Hypocalciuria | 13.00 | 12.12 | 3 | 36852 | 25 | 70891564 |
Iron deficiency | 12.97 | 12.12 | 18 | 36837 | 7738 | 70883851 |
Lung neoplasm malignant | 12.92 | 12.12 | 35 | 36820 | 24707 | 70866882 |
Duodenal ulcer | 12.79 | 12.12 | 26 | 36829 | 15254 | 70876335 |
Dyspnoea exertional | 12.76 | 12.12 | 77 | 36778 | 78353 | 70813236 |
Poor dental condition | 12.75 | 12.12 | 6 | 36849 | 525 | 70891064 |
Ephelides | 12.74 | 12.12 | 4 | 36851 | 115 | 70891474 |
Pyelonephritis acute | 12.69 | 12.12 | 15 | 36840 | 5502 | 70886087 |
Brain stem haematoma | 12.61 | 12.12 | 4 | 36851 | 119 | 70891470 |
Nail injury | 12.57 | 12.12 | 6 | 36849 | 542 | 70891047 |
Lupus nephritis | 12.53 | 12.12 | 11 | 36844 | 2843 | 70888746 |
Erectile dysfunction | 12.46 | 12.12 | 24 | 36831 | 13538 | 70878051 |
Blood urea increased | 12.39 | 12.12 | 52 | 36803 | 45857 | 70845732 |
Therapy non-responder | 12.38 | 12.12 | 13 | 36842 | 76902 | 70814687 |
Thirst | 12.35 | 12.12 | 25 | 36830 | 14624 | 70876965 |
None
Source | Code | Description |
---|---|---|
ATC | C03BA11 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, EXCL. THIAZIDES Sulfonamides, plain |
ATC | C09BX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C10BX13 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA PE | N0000175359 | Increased Diuresis |
FDA EPC | N0000175420 | Thiazide-like Diuretic |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004232 | Diuretics |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D045283 | Natriuretic Agents |
MeSH PA | D049993 | Sodium Chloride Symporter Inhibitors |
CHEBI has role | CHEBI:35498 | diuretics |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Edema | indication | 267038008 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypokalemia | contraindication | 43339004 | |
Sympathectomy | contraindication | 57071006 | |
Acute nephropathy | contraindication | 58574008 | |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Oliguria | contraindication | 83128009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Disease of liver | contraindication | 235856003 | DOID:409 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.53 | acidic |
pKa2 | 9.54 | acidic |
pKa3 | 5.52 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 12 member 3 | Transporter | INHIBITOR | A2 | 7.54 | WOMBAT-PK | CHEMBL | |||
Carbonic anhydrase 1 | Enzyme | Kd | 5 | CHEMBL | |||||
Carbonic anhydrase 4 | Enzyme | Ki | 6.67 | CHEMBL | |||||
Carbonic anhydrase 9 | Enzyme | Ki | 7.44 | CHEMBL | |||||
Carbonic anhydrase 12 | Enzyme | Ki | 8 | CHEMBL | |||||
Potassium voltage-gated channel subfamily KQT member 1 | Ion channel | WOMBAT-PK | |||||||
Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 6.05 | CHEMBL | |||||
Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 6.56 | CHEMBL | |||||
Carbonic anhydrase 7 | Enzyme | Ki | 9.64 | CHEMBL | |||||
Carbonic anhydrase 6 | Enzyme | Kd | 6.60 | CHEMBL | |||||
Carbonic anhydrase 14 | Enzyme | Ki | 5.31 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | Kd | 6.70 | CHEMBL | |||||
Carbonic anhydrase 13 | Enzyme | Kd | 7 | CHEMBL | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.54 | DRUG MATRIX | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 7.89 | CHEMBL |
ID | Source |
---|---|
4018746 | VUID |
N0000147050 | NUI |
D00345 | KEGG_DRUG |
180004-24-4 | SECONDARY_CAS_RN |
4018746 | VANDF |
C0021186 | UMLSCUI |
CHEBI:5893 | CHEBI |
BL1 | PDB_CHEM_ID |
CHEMBL406 | ChEMBL_ID |
DB00808 | DRUGBANK_ID |
D007190 | MESH_DESCRIPTOR_UI |
3702 | PUBCHEM_CID |
7203 | IUPHAR_LIGAND_ID |
3333 | INN_ID |
F089I0511L | UNII |
5764 | RXNORM |
2360 | MMSL |
4873 | MMSL |
d00260 | MMSL |
002313 | NDDF |
387419003 | SNOMEDCT_US |
725661001 | SNOMEDCT_US |
74213004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2571 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2571 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2597 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2597 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0069 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0080 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-576 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-348 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-349 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-024 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-025 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62559-510 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62559-511 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1953 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1953 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1954 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1954 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68151-1294 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68788-7247 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68788-7247 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71335-1541 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |