indapamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, sulfamoylbenzoic acid derivatives 1433 26807-65-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metindamide
  • indapamide hemihydrate
  • indapamide
  • flupamid
  • indaflex
  • indamide
  • indamol
  • veroxil
  • (+/-)-Indapamide
A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
  • Molecular weight: 365.83
  • Formula: C16H16ClN3O3S
  • CLOGP: 2.96
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 92.50
  • ALOGS: -4.03
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.59 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.20 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
July 6, 1983 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1294.91 13.63 682 20608 95457 50488377
Hypokalaemia 521.41 13.63 370 20920 87622 50496212
Acute kidney injury 236.73 13.63 377 20913 227681 50356153
Inappropriate antidiuretic hormone secretion 158.44 13.63 87 21203 13056 50570778
Confusional state 126.49 13.63 256 21034 185672 50398162
Drug interaction 105.16 13.63 248 21042 199373 50384461
Hypochloraemia 95.21 13.63 33 21257 1614 50582220
Burning mouth syndrome 89.01 13.63 23 21267 400 50583434
Hyponatraemic seizure 84.53 13.63 22 21268 394 50583440
Torsade de pointes 72.68 13.63 51 21239 11784 50572050
Conjoined twins 72.65 13.63 18 21272 262 50583572
Labile hypertension 63.37 13.63 18 21272 453 50583381
Hypomagnesaemia 62.55 13.63 62 21228 23094 50560740
Electrocardiogram QT prolonged 58.02 13.63 89 21201 51797 50532037
Congenital bladder anomaly 53.69 13.63 13 21277 171 50583663
Intestinal malrotation 53.56 13.63 15 21275 358 50583476
Urachal abnormality 53.14 13.63 13 21277 179 50583655
Persistent cloaca 52.29 13.63 13 21277 192 50583642
Maternal exposure during pregnancy 49.32 13.63 5 21285 159773 50424061
Drug ineffective 47.09 13.63 182 21108 819151 49764683
Off label use 45.88 13.63 81 21209 474345 50109489
Death 45.48 13.63 42 21248 325337 50258497
Product packaging confusion 45.13 13.63 11 21279 149 50583685
Sprue-like enteropathy 44.37 13.63 14 21276 509 50583325
Vessel puncture site haemorrhage 43.02 13.63 10 21280 109 50583725
Blood pressure increased 41.71 13.63 137 21153 132995 50450839
Left ventricular hypertrophy 39.72 13.63 25 21265 4820 50579014
Metabolic acidosis 37.08 13.63 62 21228 38763 50545071
Nasal mucosal disorder 35.48 13.63 11 21279 377 50583457
Blood sodium decreased 35.26 13.63 44 21246 21103 50562731
Renin increased 35.19 13.63 9 21281 150 50583684
Hypertensive angiopathy 34.87 13.63 8 21282 82 50583752
Croup infectious 33.76 13.63 11 21279 444 50583390
Eosinophilia 33.02 13.63 40 21250 18612 50565222
Fall 32.25 13.63 246 21044 334686 50249148
Hyperlactacidaemia 31.80 13.63 17 21273 2416 50581418
Infection 31.12 13.63 17 21273 172937 50410897
Dehydration 30.48 13.63 136 21154 152313 50431521
Exposure during pregnancy 30.07 13.63 7 21283 121008 50462826
Rectal polyp 29.09 13.63 12 21278 949 50582885
Infusion related reaction 28.62 13.63 18 21272 169539 50414295
Hypotension 28.54 13.63 183 21107 235286 50348548
Bradycardia 28.49 13.63 75 21215 64351 50519483
Dyslipidaemia 28.20 13.63 22 21268 5966 50577868
Lactic acidosis 27.60 13.63 50 21240 33305 50550529
Diabetic metabolic decompensation 27.13 13.63 13 21277 1467 50582367
Atrial fibrillation 26.89 13.63 99 21191 101646 50482188
Gravitational oedema 26.87 13.63 12 21278 1153 50582681
Orthostatic hypotension 26.72 13.63 46 21244 29435 50554399
Product dose omission issue 26.52 13.63 23 21267 183815 50400019
Systemic lupus erythematosus 26.51 13.63 13 21277 140609 50443225
Alopecia 26.28 13.63 39 21251 245008 50338826
Hypouricaemia 26.12 13.63 7 21283 141 50583693
Abdominal discomfort 25.69 13.63 36 21254 231605 50352229
Blood electrolytes abnormal 25.61 13.63 11 21279 962 50582872
Circulatory collapse 24.76 13.63 36 21254 19964 50563870
Mucocutaneous haemorrhage 24.70 13.63 6 21284 80 50583754
Vomiting 24.25 13.63 298 20992 460460 50123374
Convulsive threshold lowered 24.22 13.63 8 21282 337 50583497
Renal impairment 23.79 13.63 78 21212 75583 50508251
Platelet dysfunction 23.46 13.63 6 21284 100 50583734
Urine albumin/creatinine ratio increased 23.31 13.63 7 21283 215 50583619
Paramnesia 22.71 13.63 4 21286 8 50583826
Blood pressure inadequately controlled 22.62 13.63 17 21273 4363 50579471
Arthropathy 22.47 13.63 20 21270 157886 50425948
Dizziness 21.79 13.63 232 21058 346137 50237697
Psychomotor retardation 21.61 13.63 15 21275 3403 50580431
Sinusitis 21.52 13.63 24 21266 170534 50413300
Syncope 21.41 13.63 93 21197 102909 50480925
Treatment failure 21.37 13.63 16 21274 137621 50446213
Glossodynia 21.31 13.63 11 21279 115558 50468276
Labelled drug-drug interaction medication error 21.09 13.63 24 21266 10453 50573381
Central nervous system lupus 20.99 13.63 7 21283 304 50583530
Proctalgia 20.62 13.63 17 21273 4986 50578848
Impaired work ability 20.56 13.63 27 21263 13613 50570221
Swelling 20.54 13.63 33 21257 200839 50382995
Sensitisation 20.52 13.63 11 21279 1571 50582263
Iron deficiency 20.25 13.63 18 21272 5844 50577990
Intestinal haemorrhage 20.21 13.63 14 21276 3166 50580668
Ischaemic stroke 20.17 13.63 29 21261 15919 50567915
Hypovolaemic shock 20.08 13.63 17 21273 5171 50578663
Hepatic enzyme increased 20.03 13.63 17 21273 137363 50446471
Angioedema 19.96 13.63 47 21243 37629 50546205
Vulvovaginal inflammation 19.88 13.63 8 21282 594 50583240
Contraindicated product administered 19.87 13.63 20 21270 148938 50434896
Presyncope 19.67 13.63 36 21254 24162 50559672
Hypoglycaemia 19.39 13.63 58 21232 53523 50530311
Change of bowel habit 19.29 13.63 11 21279 1773 50582061
Glomerular filtration rate decreased 19.03 13.63 24 21266 11628 50572206
Hypotonia 18.74 13.63 20 21270 8114 50575720
Stevens-Johnson syndrome 18.49 13.63 33 21257 21719 50562115
Malaise 18.04 13.63 218 21072 335314 50248520
Fatigue 17.97 13.63 201 21089 707400 49876434
Rhabdomyolysis 17.83 13.63 46 21244 38981 50544853
Myalgia 17.83 13.63 101 21189 124218 50459616
Lower respiratory tract infection 17.64 13.63 9 21281 95192 50488642
Serratia infection 17.59 13.63 8 21282 802 50583032
Blood creatine phosphokinase increased 17.49 13.63 36 21254 26331 50557503
Metabolic alkalosis 17.30 13.63 12 21278 2719 50581115
Renal artery stenosis 17.25 13.63 10 21280 1662 50582172
Spinal pain 17.25 13.63 22 21268 10781 50573053
Haematoma 17.19 13.63 39 21251 30471 50553363
Pyelonephritis acute 17.09 13.63 14 21276 4069 50579765
Protrusion tongue 16.92 13.63 6 21284 314 50583520
Oliguria 16.84 13.63 19 21271 8197 50575637
Hospitalisation 16.73 13.63 4 21286 67933 50515901
Inclusion body myositis 16.71 13.63 3 21287 7 50583827
Normocytic anaemia 16.58 13.63 9 21281 1318 50582516
Fear of eating 16.56 13.63 6 21284 334 50583500
Anuria 16.55 13.63 22 21268 11222 50572612
Intracranial haematoma 16.31 13.63 6 21284 349 50583485
Discomfort 16.31 13.63 13 21277 108367 50475467
Urine output decreased 16.29 13.63 21 21269 10400 50573434
Blood pressure abnormal 15.86 13.63 23 21267 12724 50571110
Hypocalciuria 15.71 13.63 3 21287 11 50583823
Migraine 15.71 13.63 6 21284 75274 50508560
Leukocyturia 15.67 13.63 8 21282 1035 50582799
Injection site erythema 15.59 13.63 6 21284 74930 50508904
Red blood cell sedimentation rate abnormal 15.47 13.63 26 21264 16317 50567517
Furuncle 15.21 13.63 15 21275 5549 50578285
Arrhythmia 15.08 13.63 39 21251 33093 50550741
Rash maculo-papular 14.95 13.63 34 21256 26607 50557227
Rash 14.61 13.63 116 21174 437355 50146479
Ventricular fibrillation 14.54 13.63 20 21270 10539 50573295
Dysuria 14.49 13.63 35 21255 28469 50555365
Glycosylated haemoglobin increased 14.47 13.63 20 21270 10586 50573248
Electrocardiogram ST-T segment abnormal 14.41 13.63 5 21285 245 50583589
Swollen tongue 14.39 13.63 35 21255 28595 50555239
Wound 14.34 13.63 14 21276 105780 50478054
Neglect of personal appearance 14.30 13.63 4 21286 95 50583739
Blood urea increased 14.25 13.63 31 21259 23554 50560280
Lymphocytic infiltration 14.21 13.63 7 21283 839 50582995
Tubulointerstitial nephritis 14.13 13.63 24 21266 15187 50568647
Gastroenteritis salmonella 13.85 13.63 6 21284 536 50583298
Impaired healing 13.85 13.63 6 21284 69780 50514054
Tinnitus 13.73 13.63 34 21256 28098 50555736
Urinary incontinence 13.67 13.63 34 21256 28174 50555660

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 271.85 13.85 242 14384 67391 29492510
Hypokalaemia 222.43 13.85 190 14436 50013 29509888
Acute kidney injury 106.04 13.85 329 14297 264938 29294963
Hypomagnesaemia 70.91 13.85 63 14563 17405 29542496
Death 69.22 13.85 42 14584 342042 29217859
Drug interaction 63.62 13.85 228 14398 197157 29362744
Hyperkalaemia 40.49 13.85 92 14534 61300 29498601
Bradycardia 38.55 13.85 94 14532 65535 29494366
Lactic acidosis 36.99 13.85 59 14567 30188 29529713
Mucosal dryness 36.27 13.85 15 14611 1014 29558887
Hypoosmolar state 35.03 13.85 8 14618 67 29559834
Postictal paralysis 34.34 13.85 10 14616 233 29559668
Syncope 33.24 13.85 102 14524 81269 29478632
Left atrial dilatation 32.05 13.85 16 14610 1677 29558224
Herbal interaction 31.50 13.85 10 14616 314 29559587
Haematocrit increased 29.00 13.85 15 14611 1693 29558208
Drug abuse 28.82 13.85 3 14623 79880 29480021
Drug ineffective 27.70 13.85 90 14536 363080 29196821
Consciousness fluctuating 26.86 13.85 12 14614 980 29558921
Hypotension 26.80 13.85 176 14450 194178 29365723
Atrial fibrillation 26.54 13.85 113 14513 105533 29454368
Oedema peripheral 25.42 13.85 110 14516 103447 29456454
Renal artery arteriosclerosis 24.64 13.85 5 14621 22 29559879
Tumour invasion 24.40 13.85 8 14618 279 29559622
Haemoglobin increased 24.10 13.85 16 14610 2870 29557031
Gastrointestinal ischaemia 24.04 13.85 7 14619 163 29559738
Cholestasis 22.39 13.85 41 14585 23421 29536480
Pancreatic neoplasm 22.22 13.85 10 14616 831 29559070
Inappropriate antidiuretic hormone secretion 21.85 13.85 27 14599 10905 29548996
Myalgia 21.63 13.85 83 14543 73936 29485965
Bundle branch block right 21.06 13.85 21 14605 6696 29553205
Renal artery restenosis 20.91 13.85 4 14622 12 29559889
Lip swelling 20.65 13.85 28 14598 12382 29547519
Presyncope 20.51 13.85 32 14594 16057 29543844
Angioedema 20.10 13.85 47 14579 31868 29528033
Onychophagia 19.97 13.85 5 14621 64 29559837
Angular cheilitis 19.83 13.85 6 14620 160 29559741
Tubulointerstitial nephritis 19.65 13.85 33 14593 17610 29542291
Electrolyte imbalance 19.62 13.85 26 14600 11248 29548653
Polyuria 19.45 13.85 21 14605 7341 29552560
Glycosylated haemoglobin decreased 19.21 13.85 7 14619 336 29559565
Ventricular flutter 19.05 13.85 5 14621 78 29559823
Oedema genital 18.69 13.85 7 14619 363 29559538
Arrhythmia 18.52 13.85 45 14581 31268 29528633
Hepatic ischaemia 18.39 13.85 7 14619 380 29559521
Nail pitting 18.12 13.85 6 14620 216 29559685
Off label use 18.07 13.85 82 14544 300718 29259183
Electrocardiogram T wave abnormal 17.73 13.85 10 14616 1341 29558560
Thrombocytosis 17.53 13.85 14 14612 3339 29556562
Atrioventricular block 16.86 13.85 19 14607 6963 29552938
Metastases to peritoneum 16.64 13.85 10 14616 1510 29558391
Arterial stenosis 16.55 13.85 9 14617 1124 29558777
Neutrophilia 16.44 13.85 14 14612 3652 29556249
Hypovolaemia 16.28 13.85 20 14606 8025 29551876
Gingival hypoplasia 16.23 13.85 3 14623 7 29559894
Febrile neutropenia 16.18 13.85 19 14607 112221 29447680
Choroidal effusion 16.03 13.85 5 14621 148 29559753
Dizziness 15.78 13.85 153 14473 189531 29370370
External ear pain 15.68 13.85 3 14623 9 29559892
Nocturia 15.67 13.85 20 14606 8342 29551559
Renal failure 15.46 13.85 106 14520 118493 29441408
Electrocardiogram QT prolonged 15.39 13.85 46 14580 36091 29523810
Product dose omission issue 15.36 13.85 15 14611 96368 29463533
Face oedema 15.32 13.85 22 14604 10261 29549640
Polydipsia 15.06 13.85 13 14613 3452 29556449
Confusional state 14.77 13.85 111 14515 127766 29432135
Osmotic demyelination syndrome 14.63 13.85 7 14619 669 29559232
Parkinsonism 14.58 13.85 18 14608 7260 29552641
Obesity 14.54 13.85 21 14605 9842 29550059
Ephelides 14.51 13.85 4 14622 76 29559825
White blood cell count decreased 14.45 13.85 12 14614 83350 29476551
Dyspnoea exertional 14.19 13.85 45 14581 36445 29523456
Erectile dysfunction 14.16 13.85 29 14597 17980 29541921
Pemphigoid 14.00 13.85 18 14608 7563 29552338
Pneumonia 13.94 13.85 97 14529 320075 29239826

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1351.05 12.18 879 32478 147460 64317915
Hypokalaemia 673.31 12.18 534 32823 121369 64344006
Acute kidney injury 298.79 12.18 692 32665 448548 64016827
Drug interaction 150.05 12.18 469 32888 361614 64103761
Inappropriate antidiuretic hormone secretion 138.63 12.18 105 33252 22184 64443191
Hypomagnesaemia 133.48 12.18 128 33229 37248 64428127
Confusional state 124.84 12.18 356 33001 260788 64204587
Completed suicide 98.78 12.18 4 33353 224410 64240965
Hypochloraemia 95.33 12.18 37 33320 2024 64463351
Death 93.70 12.18 68 33289 482637 63982738
Burning mouth syndrome 80.77 12.18 23 33334 471 64464904
Hyponatraemic seizure 80.45 12.18 23 33334 478 64464897
Torsade de pointes 72.69 12.18 65 33292 17298 64448077
Off label use 67.23 12.18 142 33215 632664 63832711
Atrial fibrillation 58.48 12.18 208 33149 170881 64294494
Labile hypertension 57.47 12.18 18 33339 516 64464859
Lactic acidosis 57.26 12.18 109 33248 61301 64404074
Electrocardiogram QT prolonged 56.39 12.18 126 33231 79322 64386053
Bradycardia 55.21 12.18 160 33197 118059 64347316
Drug ineffective 51.45 12.18 242 33115 840005 63625370
Drug abuse 50.44 12.18 5 33352 132369 64333006
Syncope 47.46 12.18 184 33173 157451 64307924
Blood sodium decreased 41.66 12.18 63 33294 29419 64435956
Hypotension 40.13 12.18 335 33022 380639 64084736
Renin increased 39.21 12.18 11 33346 213 64465162
Product packaging confusion 38.87 12.18 11 33346 220 64465155
Presyncope 38.70 12.18 67 33290 35022 64430353
Left ventricular hypertrophy 38.63 12.18 35 33322 9471 64455904
Myalgia 37.50 12.18 172 33185 158445 64306930
Vessel puncture site haemorrhage 36.48 12.18 10 33347 177 64465198
Metabolic acidosis 36.00 12.18 99 33258 70859 64394516
Product dose omission issue 35.69 12.18 29 33328 194718 64270657
Nasal mucosal disorder 34.68 12.18 11 33346 329 64465046
Blood pressure increased 34.26 12.18 178 33179 172374 64293001
Dizziness 33.64 12.18 355 33002 429808 64035567
Angioedema 33.12 12.18 88 33269 61733 64403642
Febrile neutropenia 33.09 12.18 29 33328 187628 64277747
Hyperkalaemia 32.86 12.18 121 33236 101008 64364367
Sprue-like enteropathy 32.31 12.18 14 33343 1015 64464360
Hypertensive angiopathy 31.85 12.18 8 33349 99 64465276
Orthostatic hypotension 30.79 12.18 72 33285 46666 64418709
Infusion related reaction 30.75 12.18 24 33333 164443 64300932
Oedema peripheral 30.71 12.18 200 33157 210117 64255258
Postictal paralysis 30.39 12.18 10 33347 337 64465038
Hypoosmolar state 28.83 12.18 9 33348 255 64465120
Croup infectious 28.80 12.18 11 33346 576 64464799
Herbal interaction 28.47 12.18 10 33347 412 64464963
Blood pressure inadequately controlled 28.35 12.18 23 33334 5361 64460014
Toxicity to various agents 28.29 12.18 95 33262 363418 64101957
Metabolic alkalosis 27.78 12.18 20 33337 3908 64461467
Sinusitis 27.65 12.18 21 33336 145907 64319468
Treatment failure 27.48 12.18 13 33344 116803 64348572
Arrhythmia 26.99 12.18 74 33283 52870 64412505
Diabetic metabolic decompensation 26.73 12.18 17 33340 2711 64462664
Infection 26.52 12.18 34 33323 184846 64280529
Dyslipidaemia 26.29 12.18 28 33329 9214 64456161
Fall 25.86 12.18 329 33028 416497 64048878
Circulatory collapse 25.62 12.18 55 33302 33677 64431698
Tubulointerstitial nephritis 25.34 12.18 52 33305 30857 64434518
Mucosal dryness 25.25 12.18 17 33340 2984 64462391
Blood pressure abnormal 25.02 12.18 34 33323 14401 64450974
White blood cell count decreased 24.80 12.18 27 33330 157810 64307565
Exposure during pregnancy 24.77 12.18 5 33352 77670 64387705
Left atrial dilatation 24.07 12.18 16 33341 2750 64462625
Dehydration 24.05 12.18 193 33164 216570 64248805
Atrioventricular block 23.46 12.18 30 33327 11985 64453390
Rectal polyp 23.40 12.18 12 33345 1272 64464103
Rash maculo-papular 23.25 12.18 65 33292 46961 64418414
Renal failure 23.08 12.18 167 33190 181521 64283854
Electrolyte imbalance 22.53 12.18 44 33313 25199 64440176
Tumour invasion 22.38 12.18 8 33349 347 64465028
Hypoglycaemia 22.36 12.18 99 33258 89793 64375582
Eosinophilia 22.24 12.18 56 33301 38020 64427355
Pericarditis 22.21 12.18 3 33354 62513 64402862
Cholestasis 22.16 12.18 62 33295 44810 64420565
Hyperlactacidaemia 22.01 12.18 19 33338 4825 64460550
Ischaemic stroke 21.66 12.18 47 33310 28988 64436387
Gastrointestinal ischaemia 21.47 12.18 8 33349 391 64464984
Pemphigus 21.36 12.18 3 33354 60698 64404677
Bundle branch block left 21.10 12.18 26 33331 10008 64455367
Swollen tongue 21.04 12.18 52 33305 34902 64430473
Osmotic demyelination syndrome 20.98 12.18 11 33346 1220 64464155
Glycosylated haemoglobin increased 20.90 12.18 33 33324 15986 64449389
Consciousness fluctuating 20.89 12.18 12 33345 1593 64463782
Renal artery restenosis 20.73 12.18 4 33353 12 64465363
Renal artery stenosis 20.73 12.18 15 33342 2954 64462421
Hypovolaemic shock 20.62 12.18 26 33331 10240 64455135
Pneumonia 20.46 12.18 188 33169 559388 63905987
Gravitational oedema 20.43 12.18 12 33345 1660 64463715
Renal impairment 20.06 12.18 129 33228 134888 64330487
Central nervous system lupus 20.05 12.18 7 33350 283 64465092
Injection site erythema 19.78 12.18 6 33351 70794 64394581
Helicobacter test positive 19.64 12.18 10 33347 1044 64464331
Mental status changes 19.37 12.18 4 33353 61158 64404217
Haematocrit increased 19.13 12.18 15 33342 3330 64462045
Psychomotor retardation 19.08 12.18 18 33339 5125 64460250
Mucocutaneous haemorrhage 18.99 12.18 6 33351 177 64465198
Nocturia 18.90 12.18 26 33331 11139 64454236
Urine albumin/creatinine ratio increased 18.81 12.18 7 33350 341 64465034
Swelling 18.61 12.18 34 33323 160184 64305191
Paramnesia 18.36 12.18 4 33353 25 64465350
Pyrexia 18.19 12.18 193 33164 558451 63906924
Malaise 17.89 12.18 296 33061 395951 64069424
Ventricular flutter 17.72 12.18 5 33352 99 64465276
Pain 17.71 12.18 192 33165 553319 63912056
Hypouricaemia 17.69 12.18 7 33350 403 64464972
Hypovolaemia 17.64 12.18 30 33327 15456 64449919
Stevens-Johnson syndrome 17.58 12.18 48 33309 34201 64431174
Sensitisation 17.49 12.18 11 33346 1720 64463655
Platelet count decreased 17.41 12.18 38 33319 167673 64297702
Blood electrolytes abnormal 17.15 12.18 11 33346 1780 64463595
Arterial stenosis 17.08 12.18 10 33347 1375 64464000
Renal artery arteriosclerosis 17.08 12.18 4 33353 36 64465339
Haemoglobin increased 17.04 12.18 17 33340 5184 64460191
Pancreatic neoplasm 17.01 12.18 10 33347 1385 64463990
Oedema genital 16.85 12.18 7 33350 457 64464918
Lip swelling 16.66 12.18 45 33312 31862 64433513
Injection site pain 16.48 12.18 20 33337 111388 64353987
Rhabdomyolysis 16.41 12.18 92 33265 91634 64373741
Change of bowel habit 16.30 12.18 12 33345 2426 64462949
Angular cheilitis 16.30 12.18 7 33350 497 64464878
Anaemia megaloblastic 16.26 12.18 7 33350 500 64464875
Nail pitting 16.22 12.18 6 33351 287 64465088
Ventricular extrasystoles 16.19 12.18 31 33326 17498 64447877
Glomerular filtration rate decreased 16.13 12.18 33 33324 19539 64445836
Gingival hypoplasia 16.10 12.18 3 33354 7 64465368
Product use issue 16.06 12.18 34 33323 151681 64313694
Bundle branch block right 16.03 12.18 23 33334 10246 64455129
Fatigue 15.97 12.18 282 33075 748448 63716927
Pemphigoid 15.92 12.18 26 33331 12960 64452415
Glucose tolerance impaired 15.70 12.18 18 33339 6425 64458950
External ear pain 15.55 12.18 3 33354 9 64465366
Hospitalisation 15.33 12.18 10 33347 75197 64390178
Contraindicated product administered 15.28 12.18 20 33337 107809 64357566
Convulsive threshold lowered 15.23 12.18 8 33349 891 64464484
Product prescribing issue 15.09 12.18 11 33346 2190 64463185
Gingival hypertrophy 15.03 12.18 12 33345 2735 64462640
Proctalgia 14.95 12.18 19 33338 7540 64457835
Glycosylated haemoglobin decreased 14.95 12.18 7 33350 609 64464766
Platelet dysfunction 14.94 12.18 6 33351 359 64465016
Injection site reaction 14.89 12.18 3 33354 46661 64418714
Jaundice 14.88 12.18 57 33300 48455 64416920
Drug hypersensitivity 14.74 12.18 68 33289 237747 64227628
Product use in unapproved indication 14.52 12.18 45 33312 176573 64288802
Inclusion body myositis 14.51 12.18 3 33354 14 64465361
Protrusion tongue 14.46 12.18 6 33351 391 64464984
Proteinuria 14.37 12.18 39 33318 27684 64437691
Fear of eating 14.20 12.18 6 33351 409 64464966
Iron deficiency 14.13 12.18 18 33339 7159 64458216
Wrong technique in product usage process 14.13 12.18 8 33349 64966 64400409
Disease progression 13.97 12.18 33 33324 141647 64323728
Ventricular fibrillation 13.84 12.18 35 33322 23825 64441550
Spinal pain 13.78 12.18 24 33333 12597 64452778
Alopecia 13.77 12.18 42 33315 165648 64299727
Polydipsia 13.74 12.18 16 33341 5805 64459570
Hypocalcaemia 13.59 12.18 50 33307 41703 64423672
Vulvovaginal inflammation 13.36 12.18 6 33351 474 64464901
Hypocalciuria 13.35 12.18 3 33354 22 64465353
Chronic gastritis 13.30 12.18 12 33345 3228 64462147
Abdominal discomfort 13.25 12.18 49 33308 182273 64283102
Migraine 13.23 12.18 8 33349 62669 64402706
Stomatitis 12.96 12.18 23 33334 109582 64355793
Ephelides 12.86 12.18 4 33353 112 64465263
Red blood cell sedimentation rate abnormal 12.86 12.18 27 33330 16279 64449096
Brain stem haematoma 12.63 12.18 4 33353 119 64465256
Vomiting 12.48 12.18 373 32984 550744 63914631
Angina pectoris 12.25 12.18 51 33306 45030 64420345
Pain in jaw 12.23 12.18 3 33354 40752 64424623

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03BA11 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, EXCL. THIAZIDES
Sulfonamides, plain
ATC C09BX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C10BX13 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA PE N0000175359 Increased Diuresis
FDA EPC N0000175420 Thiazide-like Diuretic
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049993 Sodium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35498 diuretics
CHEBI has role CHEBI:35674 antihypertensive drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Edema indication 267038008
Anuria contraindication 2472002 DOID:2983
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hyperparathyroidism contraindication 66999008 DOID:13543
Diabetes mellitus contraindication 73211009 DOID:9351
Oliguria contraindication 83128009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.53 acidic
pKa2 9.54 acidic
pKa3 5.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 12 member 3 Transporter INHIBITOR A2 7.54 WOMBAT-PK CHEMBL
Carbonic anhydrase 1 Enzyme Kd 5 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.67 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 7.44 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 8 CHEMBL
Potassium voltage-gated channel subfamily KQT member 1 Ion channel WOMBAT-PK
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.05 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 6.56 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 9.64 CHEMBL
Carbonic anhydrase 6 Enzyme Kd 6.60 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 5.31 CHEMBL
Carbonic anhydrase 2 Enzyme Kd 6.70 CHEMBL
Carbonic anhydrase 13 Enzyme Kd 7 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 5.54 DRUG MATRIX
Carbonic anhydrase 13 Enzyme Ki 7.89 CHEMBL

External reference:

IDSource
4018746 VUID
N0000147050 NUI
D00345 KEGG_DRUG
180004-24-4 SECONDARY_CAS_RN
4018746 VANDF
C0021186 UMLSCUI
CHEBI:5893 CHEBI
BL1 PDB_CHEM_ID
CHEMBL406 ChEMBL_ID
DB00808 DRUGBANK_ID
D007190 MESH_DESCRIPTOR_UI
3702 PUBCHEM_CID
7203 IUPHAR_LIGAND_ID
3333 INN_ID
F089I0511L UNII
5764 RXNORM
2360 MMSL
4873 MMSL
d00260 MMSL
002313 NDDF
387419003 SNOMEDCT_US
725661001 SNOMEDCT_US
74213004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2571 TABLET, FILM COATED 2.50 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2597 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 21695-576 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 42291-348 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 42291-349 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 51407-024 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 51407-025 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 62559-510 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 62559-511 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1953 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1953 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1954 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1954 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 68151-1294 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 68788-7247 TABLET, FILM COATED 2.50 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 71335-1541 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections