indapamide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, sulfamoylbenzoic acid derivatives 1433 26807-65-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metindamide
  • indapamide hemihydrate
  • indapamide
  • flupamid
  • indaflex
  • indamide
  • indamol
  • veroxil
  • (+/-)-Indapamide
A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
  • Molecular weight: 365.83
  • Formula: C16H16ClN3O3S
  • CLOGP: 2.96
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 92.50
  • ALOGS: -4.03
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.59 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.20 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
July 6, 1983 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1324.96 13.59 705 22793 101434 56167135
Hypokalaemia 548.18 13.59 391 23107 94046 56174523
Acute kidney injury 235.68 13.59 386 23112 240377 56028192
Inappropriate antidiuretic hormone secretion 155.36 13.59 87 23411 13669 56254900
Confusional state 114.72 13.59 262 23236 207893 56060676
Hypochloraemia 113.74 13.59 38 23460 1674 56266895
Drug interaction 103.60 13.59 253 23245 209502 56059067
Hypomagnesaemia 97.54 13.59 82 23416 24933 56243636
Burning mouth syndrome 87.88 13.59 23 23475 425 56268144
Hyponatraemic seizure 83.73 13.59 22 23476 413 56268156
Conjoined twins 72.79 13.59 18 23480 262 56268307
Torsade de pointes 70.75 13.59 51 23447 12389 56256180
Labile hypertension 63.13 13.59 18 23480 463 56268106
Blood pressure increased 61.10 13.59 165 23333 145011 56123558
Rectal polyp 59.14 13.59 21 23477 1112 56267457
Maternal exposure during pregnancy 57.76 13.59 6 23492 189547 56079022
Drug ineffective 56.08 13.59 197 23301 918792 55349777
Electrocardiogram QT prolonged 55.14 13.59 89 23409 54499 56214070
Congenital bladder anomaly 53.79 13.59 13 23485 171 56268398
Intestinal malrotation 53.44 13.59 15 23483 364 56268205
Urachal abnormality 53.24 13.59 13 23485 179 56268390
Persistent cloaca 52.39 13.59 13 23485 192 56268377
Death 48.21 13.59 43 23455 341383 55927186
Rheumatoid arthritis 46.31 13.59 55 23443 382549 55886020
Product packaging confusion 45.22 13.59 11 23487 149 56268420
Off label use 45 13.59 104 23394 556076 55712493
Change of bowel habit 43.53 13.59 20 23478 2069 56266500
Sprue-like enteropathy 43.29 13.59 14 23484 556 56268013
Vessel puncture site haemorrhage 43.10 13.59 10 23488 109 56268460
Atrial fibrillation 43.04 13.59 121 23377 108776 56159793
Blood sodium decreased 41.66 13.59 49 23449 22285 56246284
Intestinal haemorrhage 41.59 13.59 23 23475 3523 56265046
Sensitisation 41.14 13.59 20 23478 2348 56266221
Infection 39.59 13.59 17 23481 200189 56068380
Proctalgia 39.37 13.59 26 23472 5483 56263086
Left ventricular hypertrophy 39.25 13.59 25 23473 4959 56263610
Dehydration 38.92 13.59 150 23348 158675 56109894
Metabolic acidosis 35.57 13.59 62 23436 40392 56228177
Exposure during pregnancy 35.30 13.59 7 23491 136335 56132234
Renin increased 35.14 13.59 9 23489 152 56268417
Infusion related reaction 35.00 13.59 22 23476 208909 56059660
Fall 34.97 13.59 262 23236 357248 55911321
Hypertensive angiopathy 34.67 13.59 8 23490 85 56268484
Alopecia 34.62 13.59 43 23455 293415 55975154
Nasal mucosal disorder 33.91 13.59 11 23487 441 56268128
Arthropathy 33.67 13.59 21 23477 200254 56068315
Croup infectious 33.45 13.59 11 23487 461 56268108
Systemic lupus erythematosus 32.97 13.59 17 23481 180061 56088508
Needle issue 32.73 13.59 28 23470 8710 56259859
Furuncle 32.54 13.59 24 23474 6035 56262534
Hyperlactacidaemia 30.94 13.59 17 23481 2571 56265998
Eosinophilia 30.92 13.59 40 23458 20037 56248532
Central nervous system lupus 30.78 13.59 10 23488 403 56268166
Injection site discomfort 30.62 13.59 20 23478 4140 56264429
Glossodynia 30.05 13.59 13 23485 152445 56116124
Bradycardia 29.65 13.59 78 23420 67426 56201143
Dysuria 29.53 13.59 49 23449 30680 56237889
Contraindicated product administered 29.34 13.59 21 23477 186265 56082304
Orthostatic hypotension 29.34 13.59 51 23447 33148 56235421
Duodenal ulcer 29.01 13.59 24 23474 7131 56261438
Urine odour abnormal 28.73 13.59 22 23476 5852 56262717
Product dose omission issue 28.60 13.59 26 23472 204727 56063842
Treatment failure 28.45 13.59 18 23480 170374 56098195
Swelling 28.40 13.59 35 23463 239736 56028833
Angioedema 28.29 13.59 57 23441 41396 56227173
Lactic acidosis 28.29 13.59 52 23446 35294 56233275
Hypotension 27.59 13.59 189 23309 250319 56018250
Hepatic enzyme increased 27.41 13.59 19 23479 171365 56097204
Postoperative wound infection 27.31 13.59 26 23472 9287 56259282
Dyslipidaemia 27.21 13.59 22 23476 6331 56262238
Gravitational oedema 26.86 13.59 12 23486 1163 56267406
Diabetic metabolic decompensation 26.67 13.59 13 23485 1535 56267034
Urine abnormality 26.18 13.59 22 23476 6677 56261892
Hypouricaemia 25.90 13.59 7 23491 147 56268422
Blood electrolytes abnormal 25.56 13.59 11 23487 975 56267594
Frustration tolerance decreased 25.11 13.59 21 23477 6332 56262237
Discomfort 25.04 13.59 14 23484 141747 56126822
Bladder disorder 24.67 13.59 23 23475 8001 56260568
Dizziness 24.43 13.59 252 23246 375888 55892681
Polyp 24.23 13.59 20 23478 5922 56262647
Convulsive threshold lowered 24.19 13.59 8 23490 341 56268228
Mucocutaneous haemorrhage 24.03 13.59 6 23492 91 56268478
Circulatory collapse 23.89 13.59 36 23462 20767 56247802
Abdominal discomfort 23.87 13.59 50 23448 277224 55991345
Mass 23.66 13.59 28 23470 12811 56255758
Peripheral coldness 23.66 13.59 26 23472 10985 56257584
Presyncope 23.52 13.59 40 23458 25542 56243027
Platelet dysfunction 23.39 13.59 6 23492 102 56268467
Sinusitis 23.23 13.59 29 23469 197552 56071017
Urinary incontinence 23.02 13.59 43 23455 29542 56239027
Renal impairment 22.92 13.59 80 23418 80633 56187936
Paramnesia 22.74 13.59 4 23494 8 56268561
Wound 22.71 13.59 15 23483 138789 56129780
Blood pressure inadequately controlled 22.25 13.59 17 23481 4507 56264062
Ischaemic stroke 22.04 13.59 31 23467 16811 56251758
Vomiting 21.94 13.59 310 23188 497918 55770651
Renal artery stenosis 21.86 13.59 12 23486 1811 56266758
Oliguria 21.83 13.59 22 23476 8418 56260151
Urine albumin/creatinine ratio increased 21.79 13.59 7 23491 272 56268297
Glomerular filtration rate decreased 21.27 13.59 26 23472 12303 56256266
Rhabdomyolysis 21.02 13.59 50 23448 40608 56227961
Syncope 20.86 13.59 95 23403 108104 56160465
Impaired work ability 20.84 13.59 28 23470 14544 56254025
Psychomotor retardation 20.76 13.59 15 23483 3654 56264915
Glycosylated haemoglobin increased 20.00 13.59 24 23474 11141 56257428
Hypovolaemic shock 19.68 13.59 17 23481 5356 56263213
Fatigue 19.58 13.59 223 23275 788329 55480240
Malaise 19.56 13.59 237 23261 367623 55900946
Retinal detachment 19.50 13.59 17 23481 5424 56263145
Impaired healing 19.48 13.59 6 23492 86835 56181734
Iron deficiency 19.37 13.59 18 23480 6238 56262331
Labelled drug-drug interaction medication error 19.29 13.59 24 23474 11562 56257007
Spinal pain 18.80 13.59 24 23474 11860 56256709
Blood pressure systolic increased 18.76 13.59 48 23450 40788 56227781
Rash 18.62 13.59 125 23373 492922 55775647
Pyelonephritis acute 18.56 13.59 15 23483 4314 56264255
Drug abuse 18.51 13.59 3 23495 67607 56200962
Myalgia 18.50 13.59 106 23392 131919 56136650
Butterfly rash 18.30 13.59 10 23488 1496 56267073
Hypoglycaemia 18.22 13.59 58 23440 55757 56212812
Vulvovaginal inflammation 18.11 13.59 8 23490 755 56267814
Heart rate decreased 18.04 13.59 47 23451 40380 56228189
Jaundice 17.99 13.59 37 23461 27257 56241312
Leukocyturia 17.97 13.59 9 23489 1126 56267443
Failure to suspend medication 17.83 13.59 4 23494 37 56268532
Hypotonia 17.80 13.59 20 23478 8657 56259912
Migraine 17.74 13.59 7 23491 86790 56181779
Stevens-Johnson syndrome 17.70 13.59 33 23465 22630 56245939
Anuria 17.44 13.59 23 23475 11737 56256832
Thyroid disorder 17.27 13.59 25 23473 13913 56254656
Hepatitis D 17.21 13.59 4 23494 44 56268525
Blood urea increased 17.11 13.59 34 23464 24439 56244130
Metabolic alkalosis 16.92 13.59 12 23486 2839 56265730
Serratia infection 16.89 13.59 8 23490 887 56267682
Protrusion tongue 16.85 13.59 6 23492 320 56268249
Blood glucose increased 16.79 13.59 69 23429 75082 56193487
Inclusion body myositis 16.74 13.59 3 23495 7 56268562
Fear of eating 16.39 13.59 6 23492 347 56268222
Intracranial haematoma 16.26 13.59 6 23492 355 56268214
Blood creatine phosphokinase increased 16.24 13.59 36 23462 27916 56240653
Haematoma 16.14 13.59 39 23459 31980 56236589
Drug hypersensitivity 15.97 13.59 60 23438 275145 55993424
Arrhythmia 15.87 13.59 41 23457 35042 56233527
Urine output decreased 15.86 13.59 21 23477 10756 56257813
Hypocalciuria 15.73 13.59 3 23495 11 56268558
Lung neoplasm malignant 15.73 13.59 27 23471 17369 56251200
Poor dental condition 15.56 13.59 6 23492 401 56268168
Weight increased 15.43 13.59 47 23451 229656 56038913
Hospitalisation 15.41 13.59 6 23492 74994 56193575
Normocytic anaemia 15.08 13.59 9 23489 1590 56266979
Therapeutic product effect decreased 15.04 13.59 30 23468 169422 56099147
Lupus nephritis 15.02 13.59 11 23487 2736 56265833
Blood pressure abnormal 14.79 13.59 23 23475 13637 56254932
Pain 14.73 13.59 192 23306 662992 55605577
Injection site erythema 14.63 13.59 7 23491 77441 56191128
Exostosis 14.58 13.59 24 23474 14919 56253650
Lower respiratory tract infection 14.39 13.59 16 23482 114778 56153791
Red blood cell sedimentation rate abnormal 14.35 13.59 27 23471 18646 56249923
Neglect of personal appearance 14.25 13.59 4 23494 97 56268472
Lymphocytic infiltration 14.14 13.59 7 23491 855 56267714
Ventricular fibrillation 14.09 13.59 20 23478 10932 56257637
Tubulointerstitial nephritis 13.94 13.59 25 23473 16640 56251929
Nail injury 13.93 13.59 6 23492 533 56268036
Oedema peripheral 13.70 13.59 120 23378 171134 56097435

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 281.41 14.25 259 15786 73540 31607759
Hypokalaemia 223.67 14.25 198 15847 53376 31627923
Acute kidney injury 115.27 14.25 356 15689 279358 31401941
Hypomagnesaemia 84.51 14.25 73 15972 18985 31662314
Death 75.10 14.25 45 16000 360524 31320775
Drug interaction 71.76 14.25 250 15795 208293 31473006
Hypoosmolar state 44.42 14.25 10 16035 76 31681223
Bradycardia 41.00 14.25 101 15944 69226 31612073
Mucosal dryness 37.28 14.25 16 16029 1159 31680140
Hyperkalaemia 37.25 14.25 93 15952 64258 31617041
Syncope 37.22 14.25 111 15934 85071 31596228
Completed suicide 35.17 14.25 3 16042 91511 31589788
Lactic acidosis 34.91 14.25 60 15985 31877 31649422
Left atrial dilatation 34.07 14.25 17 16028 1738 31679561
Postictal paralysis 33.87 14.25 10 16035 239 31681060
Drug abuse 33.39 14.25 3 16042 87755 31593544
Drug dispensed to wrong patient 31.21 14.25 11 16034 468 31680831
Atrial fibrillation 31.17 14.25 127 15918 113656 31567643
Drug ineffective 30.42 14.25 101 15944 395472 31285827
Herbal interaction 29.99 14.25 10 16035 359 31680940
Haematocrit increased 29.98 14.25 16 16029 1881 31679418
Hypotension 29.09 14.25 190 15855 204428 31476871
Obesity 27.58 14.25 31 16014 11069 31670230
Oedema peripheral 27.28 14.25 119 15926 109720 31571579
Consciousness fluctuating 25.29 14.25 12 16033 1099 31680200
Off label use 25.10 14.25 91 15954 347183 31334116
Haemoglobin increased 24.95 14.25 17 16028 3109 31678190
Renal artery arteriosclerosis 24.53 14.25 5 16040 22 31681277
Tumour invasion 24 14.25 8 16037 287 31681012
Gastrointestinal ischaemia 23.64 14.25 7 16038 169 31681130
Dizziness 23.63 14.25 177 15868 198970 31482329
Cholestasis 23.42 14.25 44 16001 25031 31656268
Polyuria 23.32 14.25 24 16021 7759 31673540
Myalgia 22.55 14.25 88 15957 77170 31604129
Electrolyte imbalance 22.14 14.25 29 16016 12119 31669180
Tachyarrhythmia 22.10 14.25 16 16029 3223 31678076
Inappropriate antidiuretic hormone secretion 22.04 14.25 28 16017 11359 31669940
Pancreatic neoplasm 21.64 14.25 10 16035 863 31680436
Nail pitting 20.98 14.25 7 16038 252 31681047
Renal artery restenosis 20.82 14.25 4 16041 12 31681287
Febrile neutropenia 20.36 14.25 19 16026 121830 31559469
Dyspnoea exertional 20.26 14.25 54 15991 38783 31642516
Lip swelling 20.06 14.25 29 16016 13294 31668005
Angioedema 19.87 14.25 49 15996 33569 31647730
Bundle branch block right 19.86 14.25 21 16024 7003 31674296
Onychophagia 19.86 14.25 5 16040 64 31681235
Presyncope 19.52 14.25 33 16012 17295 31664004
Angular cheilitis 19.15 14.25 6 16039 176 31681123
Hypoparathyroidism 18.99 14.25 8 16037 553 31680746
Ventricular flutter 18.94 14.25 5 16040 78 31681221
Renal pain 18.88 14.25 14 16031 2925 31678374
Glycosylated haemoglobin decreased 18.37 14.25 7 16038 372 31680927
Oedema genital 18.16 14.25 7 16038 384 31680915
Hepatic ischaemia 18.14 14.25 7 16038 385 31680914
Tubulointerstitial nephritis 17.95 14.25 33 16012 18463 31662836
Neutrophilia 17.59 14.25 15 16030 3828 31677471
Skin disorder 17.43 14.25 26 16019 12255 31669044
Arrhythmia 17.26 14.25 46 15999 33031 31648268
Hypovolaemia 16.86 14.25 21 16024 8351 31672948
Electrocardiogram T wave abnormal 16.84 14.25 10 16035 1443 31679856
Wheezing 16.75 14.25 48 15997 35938 31645361
Arterial stenosis 16.30 14.25 9 16036 1132 31680167
Gingival hypoplasia 16.16 14.25 3 16042 7 31681292
Thrombocytosis 15.96 14.25 14 16031 3709 31677590
Atrioventricular block 15.78 14.25 19 16026 7296 31674003
External ear pain 15.61 14.25 3 16042 9 31681290
Metastases to peritoneum 15.61 14.25 10 16035 1650 31679649
Pneumonia 15.43 14.25 103 15942 335209 31346090
Nocturia 15.23 14.25 21 16024 9214 31672085
Choroidal effusion 15.17 14.25 5 16040 173 31681126
Hypocalcaemia 15.13 14.25 34 16011 21944 31659355
Plasma cell myeloma 14.91 14.25 5 16040 56526 31624773
Erectile dysfunction 14.65 14.25 31 16014 19204 31662095
Polydipsia 14.56 14.25 13 16032 3527 31677772
Face oedema 14.39 14.25 22 16023 10594 31670705
Ephelides 14.27 14.25 4 16041 79 31681220

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1376.57 12.12 917 35938 159170 70732419
Hypokalaemia 695.06 12.12 562 36293 130626 70760963
Acute kidney injury 307.64 12.12 726 36129 473898 70417691
Hypomagnesaemia 180.93 12.12 158 36697 40606 70850983
Drug interaction 158.39 12.12 496 36359 380945 70510644
Inappropriate antidiuretic hormone secretion 136.31 12.12 106 36749 23170 70868419
Confusional state 113.45 12.12 365 36490 284033 70607556
Hypochloraemia 111.45 12.12 42 36813 2109 70889480
Death 99.71 12.12 72 36783 509989 70381600
Completed suicide 97.39 12.12 5 36850 227130 70664459
Atrial fibrillation 80.23 12.12 244 36611 184104 70707485
Burning mouth syndrome 79.89 12.12 23 36832 488 70891101
Hyponatraemic seizure 79.40 12.12 23 36832 499 70891090
Off label use 74.03 12.12 174 36681 742886 70148703
Torsade de pointes 70.05 12.12 65 36790 18051 70873538
Drug ineffective 62.02 12.12 265 36590 939487 69952102
Bradycardia 58.99 12.12 170 36685 124445 70767144
Labile hypertension 57.25 12.12 18 36837 520 70891069
Lactic acidosis 56.09 12.12 112 36743 64912 70826677
Drug abuse 55.31 12.12 6 36849 147250 70744339
Blood pressure increased 52.16 12.12 215 36640 188302 70703287
Electrocardiogram QT prolonged 51.79 12.12 126 36729 83391 70808198
Syncope 50.67 12.12 195 36660 165514 70726075
Rectal polyp 49.23 12.12 21 36834 1459 70890130
Maternal exposure during pregnancy 47.99 12.12 3 36852 115342 70776247
Blood sodium decreased 46.08 12.12 68 36787 30930 70860659
Dizziness 42.88 12.12 398 36457 463743 70427846
Presyncope 41.71 12.12 72 36783 37366 70854223
Hypotension 41.58 12.12 355 36500 404026 70487563
Angioedema 40.77 12.12 100 36755 66510 70825079
Febrile neutropenia 39.61 12.12 29 36826 204289 70687300
Rheumatoid arthritis 38.98 12.12 57 36798 291748 70599841
Product packaging confusion 38.82 12.12 11 36844 220 70891369
Renin increased 38.77 12.12 11 36844 221 70891368
Myalgia 38.46 12.12 181 36674 167711 70723878
Change of bowel habit 37.68 12.12 21 36834 2618 70888971
Infusion related reaction 37.06 12.12 29 36826 197505 70694084
Hypoosmolar state 36.61 12.12 11 36844 272 70891317
Vessel puncture site haemorrhage 36.44 12.12 10 36845 177 70891412
Left ventricular hypertrophy 36.37 12.12 35 36820 10167 70881422
Sensitisation 36.19 12.12 20 36835 2453 70889136
Treatment failure 35.83 12.12 15 36840 144127 70747462
Infection 34.67 12.12 35 36820 210750 70680839
Needle issue 34.38 12.12 35 36820 10880 70880709
Nasal mucosal disorder 34.04 12.12 11 36844 348 70891241
Metabolic acidosis 33.79 12.12 100 36755 74246 70817343
Toxicity to various agents 33.68 12.12 95 36760 382077 70509512
Pericarditis 32.98 12.12 3 36852 84702 70806887
Pemphigus 32.17 12.12 3 36852 83033 70808556
Hypertensive angiopathy 31.74 12.12 8 36847 100 70891489
Oedema peripheral 31.69 12.12 215 36640 227876 70663713
Sprue-like enteropathy 31.23 12.12 14 36841 1096 70890493
Orthostatic hypotension 30.94 12.12 77 36778 51666 70839923
Sinusitis 30.29 12.12 26 36829 169169 70722420
Postictal paralysis 30.06 12.12 10 36845 347 70891242
Hyperkalaemia 29.79 12.12 122 36733 106469 70785120
Blood pressure inadequately controlled 29.59 12.12 24 36831 5568 70886021
Exposure during pregnancy 29.55 12.12 5 36850 87712 70803877
Drug dispensed to wrong patient 28.91 12.12 11 36844 567 70891022
Central nervous system lupus 28.90 12.12 10 36845 392 70891197
Proctalgia 28.46 12.12 28 36827 8355 70883234
Fall 28.45 12.12 354 36501 443742 70447847
Dehydration 28.40 12.12 208 36647 225934 70665655
Croup infectious 28.13 12.12 11 36844 611 70890978
Product dose omission issue 27.56 12.12 44 36811 217424 70674165
Herbal interaction 27.37 12.12 10 36845 460 70891129
Cholestasis 27.33 12.12 70 36785 47802 70843787
Arrhythmia 26.94 12.12 77 36778 56066 70835523
Metabolic alkalosis 26.85 12.12 20 36835 4096 70887493
Mucosal dryness 26.46 12.12 18 36837 3198 70888391
Dyslipidaemia 26.40 12.12 29 36826 9831 70881758
Intestinal haemorrhage 26.02 12.12 23 36832 5997 70885592
Swelling 25.98 12.12 36 36819 188503 70703086
Left atrial dilatation 25.98 12.12 17 36838 2832 70888757
Furuncle 24.93 12.12 24 36831 6974 70884615
Diabetic metabolic decompensation 24.92 12.12 17 36838 3035 70888554
Injection site discomfort 24.62 12.12 20 36835 4649 70886940
Glycosylated haemoglobin increased 24.20 12.12 37 36818 17354 70874235
Angular cheilitis 24.18 12.12 10 36845 643 70890946
Electrolyte imbalance 24.04 12.12 47 36808 26814 70864775
Hypocalcaemia 23.97 12.12 64 36791 44795 70846794
Tubulointerstitial nephritis 23.89 12.12 53 36802 33023 70858566
Renal artery stenosis 23.79 12.12 17 36838 3267 70888322
Circulatory collapse 23.58 12.12 55 36800 35419 70856170
Urine odour abnormal 23.28 12.12 21 36834 5622 70885967
Pain 23.21 12.12 212 36643 628604 70262985
Blood pressure abnormal 23.01 12.12 34 36821 15480 70876109
Plasma cell myeloma 22.91 12.12 5 36850 73196 70818393
Contraindicated product administered 22.53 12.12 22 36833 134590 70756999
Atrioventricular block 22.06 12.12 30 36825 12658 70878931
Tumour invasion 22.04 12.12 8 36847 361 70891228
Frustration tolerance decreased 21.87 12.12 22 36833 6743 70884846
Ischaemic stroke 21.83 12.12 49 36806 30771 70860818
Jaundice 21.45 12.12 66 36789 50042 70841547
Nocturia 21.43 12.12 29 36826 12175 70879414
Gastrointestinal ischaemia 21.32 12.12 8 36847 397 70891192
Dysuria 21.19 12.12 62 36793 45732 70845857
Hyperlactacidaemia 21.17 12.12 19 36836 5053 70886536
Helicobacter test positive 21.04 12.12 11 36844 1208 70890381
Eosinophilia 21.02 12.12 57 36798 40262 70851327
Urine abnormality 20.90 12.12 23 36832 7815 70883774
Injection site erythema 20.85 12.12 6 36849 72918 70818671
Renal artery restenosis 20.71 12.12 4 36851 12 70891577
Renal failure 20.45 12.12 168 36687 188902 70702687
Drug hypersensitivity 20.43 12.12 69 36786 262390 70629199
Malaise 20.42 12.12 327 36528 432605 70458984
Osmotic demyelination syndrome 20.39 12.12 11 36844 1286 70890303
Mental status changes 20.38 12.12 4 36851 63097 70828492
Arthropathy 20.32 12.12 29 36826 150028 70741561
Rhabdomyolysis 20.30 12.12 101 36754 95659 70795930
Bundle branch block left 20.26 12.12 26 36829 10373 70881216
Rash maculo-papular 20.19 12.12 65 36790 50480 70841109
Alopecia 20.04 12.12 46 36809 198444 70693145
Haematocrit increased 19.90 12.12 16 36839 3666 70887923
Gravitational oedema 19.86 12.12 12 36843 1740 70889849
Bladder disorder 19.84 12.12 23 36832 8266 70883323
Consciousness fluctuating 19.71 12.12 12 36843 1764 70889825
Hypoglycaemia 19.63 12.12 99 36756 94265 70797324
Hypovolaemic shock 19.41 12.12 26 36829 10811 70880778
Stomatitis 19.29 12.12 23 36832 128488 70763101
Platelet count decreased 19.06 12.12 40 36815 178182 70713407
Swollen tongue 18.94 12.12 52 36803 36994 70854595
Nail pitting 18.87 12.12 7 36848 336 70891253
Lip swelling 18.62 12.12 49 36806 34005 70857584
Mucocutaneous haemorrhage 18.56 12.12 6 36849 190 70891399
Postoperative wound infection 18.50 12.12 26 36829 11312 70880277
Paramnesia 18.34 12.12 4 36851 25 70891564
Fatigue 18.29 12.12 310 36545 824009 70067580
Glomerular filtration rate decreased 18.19 12.12 36 36819 20720 70870869
Hypovolaemia 18.13 12.12 31 36824 15962 70875627
Mass 18.08 12.12 31 36824 15995 70875594
Psychomotor retardation 17.72 12.12 18 36837 5580 70886009
Ventricular flutter 17.69 12.12 5 36850 99 70891490
Haemoglobin increased 17.67 12.12 18 36837 5597 70885992
Hypouricaemia 17.45 12.12 7 36848 416 70891173
Blood glucose increased 17.34 12.12 102 36753 102880 70788709
Polyp 17.34 12.12 20 36835 7150 70884439
Renal impairment 17.26 12.12 131 36724 143806 70747783
Pneumonia 17.13 12.12 213 36642 596019 70295570
Renal artery arteriosclerosis 17.06 12.12 4 36851 36 70891553
Urine albumin/creatinine ratio increased 16.98 12.12 7 36848 446 70891143
Arterial stenosis 16.98 12.12 10 36845 1383 70890206
Blood electrolytes abnormal 16.97 12.12 11 36844 1803 70889786
Disease progression 16.89 12.12 35 36820 156637 70734952
Hypertension 16.83 12.12 231 36624 295802 70595787
Discomfort 16.77 12.12 18 36837 105418 70786171
Butterfly rash 16.74 12.12 10 36845 1420 70890169
Pancreatic neoplasm 16.66 12.12 10 36845 1433 70890156
Pyrexia 16.64 12.12 219 36636 606733 70284856
Oedema genital 16.59 12.12 7 36848 473 70891116
Impaired healing 16.54 12.12 9 36846 74365 70817224
Injection site reaction 16.44 12.12 3 36852 49849 70841740
Therapeutic product effect decreased 16.24 12.12 31 36824 142987 70748602
Gingival hypoplasia 16.08 12.12 3 36852 7 70891582
Stevens-Johnson syndrome 16.03 12.12 48 36807 35859 70855730
Product use in unapproved indication 15.83 12.12 55 36800 207423 70684166
Wrong technique in product usage process 15.74 12.12 8 36847 68690 70822899
Migraine 15.69 12.12 9 36846 72229 70819360
Systemic lupus erythematosus 15.54 12.12 18 36837 101884 70789705
Bundle branch block right 15.37 12.12 23 36832 10587 70881002
Hepatic enzyme increased 15.35 12.12 37 36818 156953 70734636
Anaemia megaloblastic 15.32 12.12 7 36848 573 70891016
Ventricular extrasystoles 15.24 12.12 31 36824 18195 70873394
White blood cell count decreased 15.18 12.12 42 36813 170099 70721490
Convulsive threshold lowered 14.99 12.12 8 36847 916 70890673
Diabetes mellitus inadequate control 14.93 12.12 35 36820 22610 70868979
Glucose tolerance impaired 14.83 12.12 18 36837 6788 70884801
Thyroid disorder 14.71 12.12 25 36830 12807 70878782
Spinal pain 14.71 12.12 26 36829 13744 70877845
Retinal detachment 14.69 12.12 20 36835 8447 70883142
Glycosylated haemoglobin decreased 14.52 12.12 7 36848 647 70890942
Inclusion body myositis 14.49 12.12 3 36852 14 70891575
Platelet dysfunction 14.41 12.12 6 36849 392 70891197
Gingival hypertrophy 14.41 12.12 12 36843 2886 70888703
Hospitalisation 14.39 12.12 13 36842 82555 70809034
Pemphigoid 14.37 12.12 26 36829 13996 70877593
External ear pain 14.32 12.12 3 36852 15 70891574
Hypersensitivity 14.32 12.12 66 36789 229746 70661843
Protrusion tongue 14.31 12.12 6 36849 399 70891190
Hypoparathyroidism 14.29 12.12 8 36847 1006 70890583
Medication error 14.24 12.12 63 36792 56849 70834740
Tachyarrhythmia 14.10 12.12 17 36838 6365 70885224
Chronic gastritis 14.04 12.12 13 36842 3600 70887989
Fear of eating 13.99 12.12 6 36849 422 70891167
Hepatitis D 13.89 12.12 4 36851 85 70891504
Proteinuria 13.81 12.12 40 36815 29334 70862255
Ventricular tachycardia 13.79 12.12 46 36809 36377 70855212
Peripheral coldness 13.74 12.12 26 36829 14474 70877115
Product use issue 13.52 12.12 48 36807 179889 70711700
Blood glucose decreased 13.45 12.12 35 36820 24124 70867465
Wound 13.44 12.12 19 36836 98713 70792876
Diabetes mellitus 13.32 12.12 73 36782 71751 70819838
Polydipsia 13.31 12.12 16 36839 5972 70885617
Vulvovaginal inflammation 13.19 12.12 6 36849 486 70891103
Pain in jaw 13.18 12.12 3 36852 42666 70848923
Abdominal discomfort 13.16 12.12 62 36793 214596 70676993
Folliculitis 13.13 12.12 3 36852 42567 70849022
Ill-defined disorder 13.11 12.12 6 36849 54735 70836854
Leukocyturia 13.08 12.12 9 36846 1628 70889961
Oliguria 13.06 12.12 26 36829 15025 70876564
Hypocalciuria 13.00 12.12 3 36852 25 70891564
Iron deficiency 12.97 12.12 18 36837 7738 70883851
Lung neoplasm malignant 12.92 12.12 35 36820 24707 70866882
Duodenal ulcer 12.79 12.12 26 36829 15254 70876335
Dyspnoea exertional 12.76 12.12 77 36778 78353 70813236
Poor dental condition 12.75 12.12 6 36849 525 70891064
Ephelides 12.74 12.12 4 36851 115 70891474
Pyelonephritis acute 12.69 12.12 15 36840 5502 70886087
Brain stem haematoma 12.61 12.12 4 36851 119 70891470
Nail injury 12.57 12.12 6 36849 542 70891047
Lupus nephritis 12.53 12.12 11 36844 2843 70888746
Erectile dysfunction 12.46 12.12 24 36831 13538 70878051
Blood urea increased 12.39 12.12 52 36803 45857 70845732
Therapy non-responder 12.38 12.12 13 36842 76902 70814687
Thirst 12.35 12.12 25 36830 14624 70876965

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03BA11 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, EXCL. THIAZIDES
Sulfonamides, plain
ATC C09BX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C10BX13 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA PE N0000175359 Increased Diuresis
FDA EPC N0000175420 Thiazide-like Diuretic
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049993 Sodium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35498 diuretics
CHEBI has role CHEBI:35674 antihypertensive drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Edema indication 267038008
Anuria contraindication 2472002 DOID:2983
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hyperparathyroidism contraindication 66999008 DOID:13543
Diabetes mellitus contraindication 73211009 DOID:9351
Oliguria contraindication 83128009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Disease of liver contraindication 235856003 DOID:409




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.53 acidic
pKa2 9.54 acidic
pKa3 5.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 3 Transporter INHIBITOR A2 7.54 WOMBAT-PK CHEMBL
Carbonic anhydrase 1 Enzyme Kd 5 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.67 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 7.44 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 8 CHEMBL
Potassium voltage-gated channel subfamily KQT member 1 Ion channel WOMBAT-PK
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.05 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 6.56 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 9.64 CHEMBL
Carbonic anhydrase 6 Enzyme Kd 6.60 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 5.31 CHEMBL
Carbonic anhydrase 2 Enzyme Kd 6.70 CHEMBL
Carbonic anhydrase 13 Enzyme Kd 7 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 5.54 DRUG MATRIX
Carbonic anhydrase 13 Enzyme Ki 7.89 CHEMBL

External reference:

IDSource
4018746 VUID
N0000147050 NUI
D00345 KEGG_DRUG
180004-24-4 SECONDARY_CAS_RN
4018746 VANDF
C0021186 UMLSCUI
CHEBI:5893 CHEBI
BL1 PDB_CHEM_ID
CHEMBL406 ChEMBL_ID
DB00808 DRUGBANK_ID
D007190 MESH_DESCRIPTOR_UI
3702 PUBCHEM_CID
7203 IUPHAR_LIGAND_ID
3333 INN_ID
F089I0511L UNII
5764 RXNORM
2360 MMSL
4873 MMSL
d00260 MMSL
002313 NDDF
387419003 SNOMEDCT_US
725661001 SNOMEDCT_US
74213004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2571 TABLET, FILM COATED 2.50 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2571 TABLET, FILM COATED 2.50 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2597 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2597 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0069 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0080 TABLET, FILM COATED 2.50 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 21695-576 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 42291-348 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 42291-349 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 51407-024 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 51407-025 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 62559-510 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 62559-511 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1953 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1953 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1954 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1954 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 68151-1294 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 68788-7247 TABLET, FILM COATED 2.50 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 68788-7247 TABLET, FILM COATED 2.50 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 71335-1541 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections