Stem definition | Drug id | CAS RN |
---|---|---|
diuretics, sulfamoylbenzoic acid derivatives | 1433 | 26807-65-8 |
Dose | Unit | Route |
---|---|---|
2.50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.59 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 7 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.20 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
July 6, 1983 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyponatraemia | 1294.91 | 13.63 | 682 | 20608 | 95457 | 50488377 |
Hypokalaemia | 521.41 | 13.63 | 370 | 20920 | 87622 | 50496212 |
Acute kidney injury | 236.73 | 13.63 | 377 | 20913 | 227681 | 50356153 |
Inappropriate antidiuretic hormone secretion | 158.44 | 13.63 | 87 | 21203 | 13056 | 50570778 |
Confusional state | 126.49 | 13.63 | 256 | 21034 | 185672 | 50398162 |
Drug interaction | 105.16 | 13.63 | 248 | 21042 | 199373 | 50384461 |
Hypochloraemia | 95.21 | 13.63 | 33 | 21257 | 1614 | 50582220 |
Burning mouth syndrome | 89.01 | 13.63 | 23 | 21267 | 400 | 50583434 |
Hyponatraemic seizure | 84.53 | 13.63 | 22 | 21268 | 394 | 50583440 |
Torsade de pointes | 72.68 | 13.63 | 51 | 21239 | 11784 | 50572050 |
Conjoined twins | 72.65 | 13.63 | 18 | 21272 | 262 | 50583572 |
Labile hypertension | 63.37 | 13.63 | 18 | 21272 | 453 | 50583381 |
Hypomagnesaemia | 62.55 | 13.63 | 62 | 21228 | 23094 | 50560740 |
Electrocardiogram QT prolonged | 58.02 | 13.63 | 89 | 21201 | 51797 | 50532037 |
Congenital bladder anomaly | 53.69 | 13.63 | 13 | 21277 | 171 | 50583663 |
Intestinal malrotation | 53.56 | 13.63 | 15 | 21275 | 358 | 50583476 |
Urachal abnormality | 53.14 | 13.63 | 13 | 21277 | 179 | 50583655 |
Persistent cloaca | 52.29 | 13.63 | 13 | 21277 | 192 | 50583642 |
Maternal exposure during pregnancy | 49.32 | 13.63 | 5 | 21285 | 159773 | 50424061 |
Drug ineffective | 47.09 | 13.63 | 182 | 21108 | 819151 | 49764683 |
Off label use | 45.88 | 13.63 | 81 | 21209 | 474345 | 50109489 |
Death | 45.48 | 13.63 | 42 | 21248 | 325337 | 50258497 |
Product packaging confusion | 45.13 | 13.63 | 11 | 21279 | 149 | 50583685 |
Sprue-like enteropathy | 44.37 | 13.63 | 14 | 21276 | 509 | 50583325 |
Vessel puncture site haemorrhage | 43.02 | 13.63 | 10 | 21280 | 109 | 50583725 |
Blood pressure increased | 41.71 | 13.63 | 137 | 21153 | 132995 | 50450839 |
Left ventricular hypertrophy | 39.72 | 13.63 | 25 | 21265 | 4820 | 50579014 |
Metabolic acidosis | 37.08 | 13.63 | 62 | 21228 | 38763 | 50545071 |
Nasal mucosal disorder | 35.48 | 13.63 | 11 | 21279 | 377 | 50583457 |
Blood sodium decreased | 35.26 | 13.63 | 44 | 21246 | 21103 | 50562731 |
Renin increased | 35.19 | 13.63 | 9 | 21281 | 150 | 50583684 |
Hypertensive angiopathy | 34.87 | 13.63 | 8 | 21282 | 82 | 50583752 |
Croup infectious | 33.76 | 13.63 | 11 | 21279 | 444 | 50583390 |
Eosinophilia | 33.02 | 13.63 | 40 | 21250 | 18612 | 50565222 |
Fall | 32.25 | 13.63 | 246 | 21044 | 334686 | 50249148 |
Hyperlactacidaemia | 31.80 | 13.63 | 17 | 21273 | 2416 | 50581418 |
Infection | 31.12 | 13.63 | 17 | 21273 | 172937 | 50410897 |
Dehydration | 30.48 | 13.63 | 136 | 21154 | 152313 | 50431521 |
Exposure during pregnancy | 30.07 | 13.63 | 7 | 21283 | 121008 | 50462826 |
Rectal polyp | 29.09 | 13.63 | 12 | 21278 | 949 | 50582885 |
Infusion related reaction | 28.62 | 13.63 | 18 | 21272 | 169539 | 50414295 |
Hypotension | 28.54 | 13.63 | 183 | 21107 | 235286 | 50348548 |
Bradycardia | 28.49 | 13.63 | 75 | 21215 | 64351 | 50519483 |
Dyslipidaemia | 28.20 | 13.63 | 22 | 21268 | 5966 | 50577868 |
Lactic acidosis | 27.60 | 13.63 | 50 | 21240 | 33305 | 50550529 |
Diabetic metabolic decompensation | 27.13 | 13.63 | 13 | 21277 | 1467 | 50582367 |
Atrial fibrillation | 26.89 | 13.63 | 99 | 21191 | 101646 | 50482188 |
Gravitational oedema | 26.87 | 13.63 | 12 | 21278 | 1153 | 50582681 |
Orthostatic hypotension | 26.72 | 13.63 | 46 | 21244 | 29435 | 50554399 |
Product dose omission issue | 26.52 | 13.63 | 23 | 21267 | 183815 | 50400019 |
Systemic lupus erythematosus | 26.51 | 13.63 | 13 | 21277 | 140609 | 50443225 |
Alopecia | 26.28 | 13.63 | 39 | 21251 | 245008 | 50338826 |
Hypouricaemia | 26.12 | 13.63 | 7 | 21283 | 141 | 50583693 |
Abdominal discomfort | 25.69 | 13.63 | 36 | 21254 | 231605 | 50352229 |
Blood electrolytes abnormal | 25.61 | 13.63 | 11 | 21279 | 962 | 50582872 |
Circulatory collapse | 24.76 | 13.63 | 36 | 21254 | 19964 | 50563870 |
Mucocutaneous haemorrhage | 24.70 | 13.63 | 6 | 21284 | 80 | 50583754 |
Vomiting | 24.25 | 13.63 | 298 | 20992 | 460460 | 50123374 |
Convulsive threshold lowered | 24.22 | 13.63 | 8 | 21282 | 337 | 50583497 |
Renal impairment | 23.79 | 13.63 | 78 | 21212 | 75583 | 50508251 |
Platelet dysfunction | 23.46 | 13.63 | 6 | 21284 | 100 | 50583734 |
Urine albumin/creatinine ratio increased | 23.31 | 13.63 | 7 | 21283 | 215 | 50583619 |
Paramnesia | 22.71 | 13.63 | 4 | 21286 | 8 | 50583826 |
Blood pressure inadequately controlled | 22.62 | 13.63 | 17 | 21273 | 4363 | 50579471 |
Arthropathy | 22.47 | 13.63 | 20 | 21270 | 157886 | 50425948 |
Dizziness | 21.79 | 13.63 | 232 | 21058 | 346137 | 50237697 |
Psychomotor retardation | 21.61 | 13.63 | 15 | 21275 | 3403 | 50580431 |
Sinusitis | 21.52 | 13.63 | 24 | 21266 | 170534 | 50413300 |
Syncope | 21.41 | 13.63 | 93 | 21197 | 102909 | 50480925 |
Treatment failure | 21.37 | 13.63 | 16 | 21274 | 137621 | 50446213 |
Glossodynia | 21.31 | 13.63 | 11 | 21279 | 115558 | 50468276 |
Labelled drug-drug interaction medication error | 21.09 | 13.63 | 24 | 21266 | 10453 | 50573381 |
Central nervous system lupus | 20.99 | 13.63 | 7 | 21283 | 304 | 50583530 |
Proctalgia | 20.62 | 13.63 | 17 | 21273 | 4986 | 50578848 |
Impaired work ability | 20.56 | 13.63 | 27 | 21263 | 13613 | 50570221 |
Swelling | 20.54 | 13.63 | 33 | 21257 | 200839 | 50382995 |
Sensitisation | 20.52 | 13.63 | 11 | 21279 | 1571 | 50582263 |
Iron deficiency | 20.25 | 13.63 | 18 | 21272 | 5844 | 50577990 |
Intestinal haemorrhage | 20.21 | 13.63 | 14 | 21276 | 3166 | 50580668 |
Ischaemic stroke | 20.17 | 13.63 | 29 | 21261 | 15919 | 50567915 |
Hypovolaemic shock | 20.08 | 13.63 | 17 | 21273 | 5171 | 50578663 |
Hepatic enzyme increased | 20.03 | 13.63 | 17 | 21273 | 137363 | 50446471 |
Angioedema | 19.96 | 13.63 | 47 | 21243 | 37629 | 50546205 |
Vulvovaginal inflammation | 19.88 | 13.63 | 8 | 21282 | 594 | 50583240 |
Contraindicated product administered | 19.87 | 13.63 | 20 | 21270 | 148938 | 50434896 |
Presyncope | 19.67 | 13.63 | 36 | 21254 | 24162 | 50559672 |
Hypoglycaemia | 19.39 | 13.63 | 58 | 21232 | 53523 | 50530311 |
Change of bowel habit | 19.29 | 13.63 | 11 | 21279 | 1773 | 50582061 |
Glomerular filtration rate decreased | 19.03 | 13.63 | 24 | 21266 | 11628 | 50572206 |
Hypotonia | 18.74 | 13.63 | 20 | 21270 | 8114 | 50575720 |
Stevens-Johnson syndrome | 18.49 | 13.63 | 33 | 21257 | 21719 | 50562115 |
Malaise | 18.04 | 13.63 | 218 | 21072 | 335314 | 50248520 |
Fatigue | 17.97 | 13.63 | 201 | 21089 | 707400 | 49876434 |
Rhabdomyolysis | 17.83 | 13.63 | 46 | 21244 | 38981 | 50544853 |
Myalgia | 17.83 | 13.63 | 101 | 21189 | 124218 | 50459616 |
Lower respiratory tract infection | 17.64 | 13.63 | 9 | 21281 | 95192 | 50488642 |
Serratia infection | 17.59 | 13.63 | 8 | 21282 | 802 | 50583032 |
Blood creatine phosphokinase increased | 17.49 | 13.63 | 36 | 21254 | 26331 | 50557503 |
Metabolic alkalosis | 17.30 | 13.63 | 12 | 21278 | 2719 | 50581115 |
Renal artery stenosis | 17.25 | 13.63 | 10 | 21280 | 1662 | 50582172 |
Spinal pain | 17.25 | 13.63 | 22 | 21268 | 10781 | 50573053 |
Haematoma | 17.19 | 13.63 | 39 | 21251 | 30471 | 50553363 |
Pyelonephritis acute | 17.09 | 13.63 | 14 | 21276 | 4069 | 50579765 |
Protrusion tongue | 16.92 | 13.63 | 6 | 21284 | 314 | 50583520 |
Oliguria | 16.84 | 13.63 | 19 | 21271 | 8197 | 50575637 |
Hospitalisation | 16.73 | 13.63 | 4 | 21286 | 67933 | 50515901 |
Inclusion body myositis | 16.71 | 13.63 | 3 | 21287 | 7 | 50583827 |
Normocytic anaemia | 16.58 | 13.63 | 9 | 21281 | 1318 | 50582516 |
Fear of eating | 16.56 | 13.63 | 6 | 21284 | 334 | 50583500 |
Anuria | 16.55 | 13.63 | 22 | 21268 | 11222 | 50572612 |
Intracranial haematoma | 16.31 | 13.63 | 6 | 21284 | 349 | 50583485 |
Discomfort | 16.31 | 13.63 | 13 | 21277 | 108367 | 50475467 |
Urine output decreased | 16.29 | 13.63 | 21 | 21269 | 10400 | 50573434 |
Blood pressure abnormal | 15.86 | 13.63 | 23 | 21267 | 12724 | 50571110 |
Hypocalciuria | 15.71 | 13.63 | 3 | 21287 | 11 | 50583823 |
Migraine | 15.71 | 13.63 | 6 | 21284 | 75274 | 50508560 |
Leukocyturia | 15.67 | 13.63 | 8 | 21282 | 1035 | 50582799 |
Injection site erythema | 15.59 | 13.63 | 6 | 21284 | 74930 | 50508904 |
Red blood cell sedimentation rate abnormal | 15.47 | 13.63 | 26 | 21264 | 16317 | 50567517 |
Furuncle | 15.21 | 13.63 | 15 | 21275 | 5549 | 50578285 |
Arrhythmia | 15.08 | 13.63 | 39 | 21251 | 33093 | 50550741 |
Rash maculo-papular | 14.95 | 13.63 | 34 | 21256 | 26607 | 50557227 |
Rash | 14.61 | 13.63 | 116 | 21174 | 437355 | 50146479 |
Ventricular fibrillation | 14.54 | 13.63 | 20 | 21270 | 10539 | 50573295 |
Dysuria | 14.49 | 13.63 | 35 | 21255 | 28469 | 50555365 |
Glycosylated haemoglobin increased | 14.47 | 13.63 | 20 | 21270 | 10586 | 50573248 |
Electrocardiogram ST-T segment abnormal | 14.41 | 13.63 | 5 | 21285 | 245 | 50583589 |
Swollen tongue | 14.39 | 13.63 | 35 | 21255 | 28595 | 50555239 |
Wound | 14.34 | 13.63 | 14 | 21276 | 105780 | 50478054 |
Neglect of personal appearance | 14.30 | 13.63 | 4 | 21286 | 95 | 50583739 |
Blood urea increased | 14.25 | 13.63 | 31 | 21259 | 23554 | 50560280 |
Lymphocytic infiltration | 14.21 | 13.63 | 7 | 21283 | 839 | 50582995 |
Tubulointerstitial nephritis | 14.13 | 13.63 | 24 | 21266 | 15187 | 50568647 |
Gastroenteritis salmonella | 13.85 | 13.63 | 6 | 21284 | 536 | 50583298 |
Impaired healing | 13.85 | 13.63 | 6 | 21284 | 69780 | 50514054 |
Tinnitus | 13.73 | 13.63 | 34 | 21256 | 28098 | 50555736 |
Urinary incontinence | 13.67 | 13.63 | 34 | 21256 | 28174 | 50555660 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyponatraemia | 271.85 | 13.85 | 242 | 14384 | 67391 | 29492510 |
Hypokalaemia | 222.43 | 13.85 | 190 | 14436 | 50013 | 29509888 |
Acute kidney injury | 106.04 | 13.85 | 329 | 14297 | 264938 | 29294963 |
Hypomagnesaemia | 70.91 | 13.85 | 63 | 14563 | 17405 | 29542496 |
Death | 69.22 | 13.85 | 42 | 14584 | 342042 | 29217859 |
Drug interaction | 63.62 | 13.85 | 228 | 14398 | 197157 | 29362744 |
Hyperkalaemia | 40.49 | 13.85 | 92 | 14534 | 61300 | 29498601 |
Bradycardia | 38.55 | 13.85 | 94 | 14532 | 65535 | 29494366 |
Lactic acidosis | 36.99 | 13.85 | 59 | 14567 | 30188 | 29529713 |
Mucosal dryness | 36.27 | 13.85 | 15 | 14611 | 1014 | 29558887 |
Hypoosmolar state | 35.03 | 13.85 | 8 | 14618 | 67 | 29559834 |
Postictal paralysis | 34.34 | 13.85 | 10 | 14616 | 233 | 29559668 |
Syncope | 33.24 | 13.85 | 102 | 14524 | 81269 | 29478632 |
Left atrial dilatation | 32.05 | 13.85 | 16 | 14610 | 1677 | 29558224 |
Herbal interaction | 31.50 | 13.85 | 10 | 14616 | 314 | 29559587 |
Haematocrit increased | 29.00 | 13.85 | 15 | 14611 | 1693 | 29558208 |
Drug abuse | 28.82 | 13.85 | 3 | 14623 | 79880 | 29480021 |
Drug ineffective | 27.70 | 13.85 | 90 | 14536 | 363080 | 29196821 |
Consciousness fluctuating | 26.86 | 13.85 | 12 | 14614 | 980 | 29558921 |
Hypotension | 26.80 | 13.85 | 176 | 14450 | 194178 | 29365723 |
Atrial fibrillation | 26.54 | 13.85 | 113 | 14513 | 105533 | 29454368 |
Oedema peripheral | 25.42 | 13.85 | 110 | 14516 | 103447 | 29456454 |
Renal artery arteriosclerosis | 24.64 | 13.85 | 5 | 14621 | 22 | 29559879 |
Tumour invasion | 24.40 | 13.85 | 8 | 14618 | 279 | 29559622 |
Haemoglobin increased | 24.10 | 13.85 | 16 | 14610 | 2870 | 29557031 |
Gastrointestinal ischaemia | 24.04 | 13.85 | 7 | 14619 | 163 | 29559738 |
Cholestasis | 22.39 | 13.85 | 41 | 14585 | 23421 | 29536480 |
Pancreatic neoplasm | 22.22 | 13.85 | 10 | 14616 | 831 | 29559070 |
Inappropriate antidiuretic hormone secretion | 21.85 | 13.85 | 27 | 14599 | 10905 | 29548996 |
Myalgia | 21.63 | 13.85 | 83 | 14543 | 73936 | 29485965 |
Bundle branch block right | 21.06 | 13.85 | 21 | 14605 | 6696 | 29553205 |
Renal artery restenosis | 20.91 | 13.85 | 4 | 14622 | 12 | 29559889 |
Lip swelling | 20.65 | 13.85 | 28 | 14598 | 12382 | 29547519 |
Presyncope | 20.51 | 13.85 | 32 | 14594 | 16057 | 29543844 |
Angioedema | 20.10 | 13.85 | 47 | 14579 | 31868 | 29528033 |
Onychophagia | 19.97 | 13.85 | 5 | 14621 | 64 | 29559837 |
Angular cheilitis | 19.83 | 13.85 | 6 | 14620 | 160 | 29559741 |
Tubulointerstitial nephritis | 19.65 | 13.85 | 33 | 14593 | 17610 | 29542291 |
Electrolyte imbalance | 19.62 | 13.85 | 26 | 14600 | 11248 | 29548653 |
Polyuria | 19.45 | 13.85 | 21 | 14605 | 7341 | 29552560 |
Glycosylated haemoglobin decreased | 19.21 | 13.85 | 7 | 14619 | 336 | 29559565 |
Ventricular flutter | 19.05 | 13.85 | 5 | 14621 | 78 | 29559823 |
Oedema genital | 18.69 | 13.85 | 7 | 14619 | 363 | 29559538 |
Arrhythmia | 18.52 | 13.85 | 45 | 14581 | 31268 | 29528633 |
Hepatic ischaemia | 18.39 | 13.85 | 7 | 14619 | 380 | 29559521 |
Nail pitting | 18.12 | 13.85 | 6 | 14620 | 216 | 29559685 |
Off label use | 18.07 | 13.85 | 82 | 14544 | 300718 | 29259183 |
Electrocardiogram T wave abnormal | 17.73 | 13.85 | 10 | 14616 | 1341 | 29558560 |
Thrombocytosis | 17.53 | 13.85 | 14 | 14612 | 3339 | 29556562 |
Atrioventricular block | 16.86 | 13.85 | 19 | 14607 | 6963 | 29552938 |
Metastases to peritoneum | 16.64 | 13.85 | 10 | 14616 | 1510 | 29558391 |
Arterial stenosis | 16.55 | 13.85 | 9 | 14617 | 1124 | 29558777 |
Neutrophilia | 16.44 | 13.85 | 14 | 14612 | 3652 | 29556249 |
Hypovolaemia | 16.28 | 13.85 | 20 | 14606 | 8025 | 29551876 |
Gingival hypoplasia | 16.23 | 13.85 | 3 | 14623 | 7 | 29559894 |
Febrile neutropenia | 16.18 | 13.85 | 19 | 14607 | 112221 | 29447680 |
Choroidal effusion | 16.03 | 13.85 | 5 | 14621 | 148 | 29559753 |
Dizziness | 15.78 | 13.85 | 153 | 14473 | 189531 | 29370370 |
External ear pain | 15.68 | 13.85 | 3 | 14623 | 9 | 29559892 |
Nocturia | 15.67 | 13.85 | 20 | 14606 | 8342 | 29551559 |
Renal failure | 15.46 | 13.85 | 106 | 14520 | 118493 | 29441408 |
Electrocardiogram QT prolonged | 15.39 | 13.85 | 46 | 14580 | 36091 | 29523810 |
Product dose omission issue | 15.36 | 13.85 | 15 | 14611 | 96368 | 29463533 |
Face oedema | 15.32 | 13.85 | 22 | 14604 | 10261 | 29549640 |
Polydipsia | 15.06 | 13.85 | 13 | 14613 | 3452 | 29556449 |
Confusional state | 14.77 | 13.85 | 111 | 14515 | 127766 | 29432135 |
Osmotic demyelination syndrome | 14.63 | 13.85 | 7 | 14619 | 669 | 29559232 |
Parkinsonism | 14.58 | 13.85 | 18 | 14608 | 7260 | 29552641 |
Obesity | 14.54 | 13.85 | 21 | 14605 | 9842 | 29550059 |
Ephelides | 14.51 | 13.85 | 4 | 14622 | 76 | 29559825 |
White blood cell count decreased | 14.45 | 13.85 | 12 | 14614 | 83350 | 29476551 |
Dyspnoea exertional | 14.19 | 13.85 | 45 | 14581 | 36445 | 29523456 |
Erectile dysfunction | 14.16 | 13.85 | 29 | 14597 | 17980 | 29541921 |
Pemphigoid | 14.00 | 13.85 | 18 | 14608 | 7563 | 29552338 |
Pneumonia | 13.94 | 13.85 | 97 | 14529 | 320075 | 29239826 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyponatraemia | 1351.05 | 12.18 | 879 | 32478 | 147460 | 64317915 |
Hypokalaemia | 673.31 | 12.18 | 534 | 32823 | 121369 | 64344006 |
Acute kidney injury | 298.79 | 12.18 | 692 | 32665 | 448548 | 64016827 |
Drug interaction | 150.05 | 12.18 | 469 | 32888 | 361614 | 64103761 |
Inappropriate antidiuretic hormone secretion | 138.63 | 12.18 | 105 | 33252 | 22184 | 64443191 |
Hypomagnesaemia | 133.48 | 12.18 | 128 | 33229 | 37248 | 64428127 |
Confusional state | 124.84 | 12.18 | 356 | 33001 | 260788 | 64204587 |
Completed suicide | 98.78 | 12.18 | 4 | 33353 | 224410 | 64240965 |
Hypochloraemia | 95.33 | 12.18 | 37 | 33320 | 2024 | 64463351 |
Death | 93.70 | 12.18 | 68 | 33289 | 482637 | 63982738 |
Burning mouth syndrome | 80.77 | 12.18 | 23 | 33334 | 471 | 64464904 |
Hyponatraemic seizure | 80.45 | 12.18 | 23 | 33334 | 478 | 64464897 |
Torsade de pointes | 72.69 | 12.18 | 65 | 33292 | 17298 | 64448077 |
Off label use | 67.23 | 12.18 | 142 | 33215 | 632664 | 63832711 |
Atrial fibrillation | 58.48 | 12.18 | 208 | 33149 | 170881 | 64294494 |
Labile hypertension | 57.47 | 12.18 | 18 | 33339 | 516 | 64464859 |
Lactic acidosis | 57.26 | 12.18 | 109 | 33248 | 61301 | 64404074 |
Electrocardiogram QT prolonged | 56.39 | 12.18 | 126 | 33231 | 79322 | 64386053 |
Bradycardia | 55.21 | 12.18 | 160 | 33197 | 118059 | 64347316 |
Drug ineffective | 51.45 | 12.18 | 242 | 33115 | 840005 | 63625370 |
Drug abuse | 50.44 | 12.18 | 5 | 33352 | 132369 | 64333006 |
Syncope | 47.46 | 12.18 | 184 | 33173 | 157451 | 64307924 |
Blood sodium decreased | 41.66 | 12.18 | 63 | 33294 | 29419 | 64435956 |
Hypotension | 40.13 | 12.18 | 335 | 33022 | 380639 | 64084736 |
Renin increased | 39.21 | 12.18 | 11 | 33346 | 213 | 64465162 |
Product packaging confusion | 38.87 | 12.18 | 11 | 33346 | 220 | 64465155 |
Presyncope | 38.70 | 12.18 | 67 | 33290 | 35022 | 64430353 |
Left ventricular hypertrophy | 38.63 | 12.18 | 35 | 33322 | 9471 | 64455904 |
Myalgia | 37.50 | 12.18 | 172 | 33185 | 158445 | 64306930 |
Vessel puncture site haemorrhage | 36.48 | 12.18 | 10 | 33347 | 177 | 64465198 |
Metabolic acidosis | 36.00 | 12.18 | 99 | 33258 | 70859 | 64394516 |
Product dose omission issue | 35.69 | 12.18 | 29 | 33328 | 194718 | 64270657 |
Nasal mucosal disorder | 34.68 | 12.18 | 11 | 33346 | 329 | 64465046 |
Blood pressure increased | 34.26 | 12.18 | 178 | 33179 | 172374 | 64293001 |
Dizziness | 33.64 | 12.18 | 355 | 33002 | 429808 | 64035567 |
Angioedema | 33.12 | 12.18 | 88 | 33269 | 61733 | 64403642 |
Febrile neutropenia | 33.09 | 12.18 | 29 | 33328 | 187628 | 64277747 |
Hyperkalaemia | 32.86 | 12.18 | 121 | 33236 | 101008 | 64364367 |
Sprue-like enteropathy | 32.31 | 12.18 | 14 | 33343 | 1015 | 64464360 |
Hypertensive angiopathy | 31.85 | 12.18 | 8 | 33349 | 99 | 64465276 |
Orthostatic hypotension | 30.79 | 12.18 | 72 | 33285 | 46666 | 64418709 |
Infusion related reaction | 30.75 | 12.18 | 24 | 33333 | 164443 | 64300932 |
Oedema peripheral | 30.71 | 12.18 | 200 | 33157 | 210117 | 64255258 |
Postictal paralysis | 30.39 | 12.18 | 10 | 33347 | 337 | 64465038 |
Hypoosmolar state | 28.83 | 12.18 | 9 | 33348 | 255 | 64465120 |
Croup infectious | 28.80 | 12.18 | 11 | 33346 | 576 | 64464799 |
Herbal interaction | 28.47 | 12.18 | 10 | 33347 | 412 | 64464963 |
Blood pressure inadequately controlled | 28.35 | 12.18 | 23 | 33334 | 5361 | 64460014 |
Toxicity to various agents | 28.29 | 12.18 | 95 | 33262 | 363418 | 64101957 |
Metabolic alkalosis | 27.78 | 12.18 | 20 | 33337 | 3908 | 64461467 |
Sinusitis | 27.65 | 12.18 | 21 | 33336 | 145907 | 64319468 |
Treatment failure | 27.48 | 12.18 | 13 | 33344 | 116803 | 64348572 |
Arrhythmia | 26.99 | 12.18 | 74 | 33283 | 52870 | 64412505 |
Diabetic metabolic decompensation | 26.73 | 12.18 | 17 | 33340 | 2711 | 64462664 |
Infection | 26.52 | 12.18 | 34 | 33323 | 184846 | 64280529 |
Dyslipidaemia | 26.29 | 12.18 | 28 | 33329 | 9214 | 64456161 |
Fall | 25.86 | 12.18 | 329 | 33028 | 416497 | 64048878 |
Circulatory collapse | 25.62 | 12.18 | 55 | 33302 | 33677 | 64431698 |
Tubulointerstitial nephritis | 25.34 | 12.18 | 52 | 33305 | 30857 | 64434518 |
Mucosal dryness | 25.25 | 12.18 | 17 | 33340 | 2984 | 64462391 |
Blood pressure abnormal | 25.02 | 12.18 | 34 | 33323 | 14401 | 64450974 |
White blood cell count decreased | 24.80 | 12.18 | 27 | 33330 | 157810 | 64307565 |
Exposure during pregnancy | 24.77 | 12.18 | 5 | 33352 | 77670 | 64387705 |
Left atrial dilatation | 24.07 | 12.18 | 16 | 33341 | 2750 | 64462625 |
Dehydration | 24.05 | 12.18 | 193 | 33164 | 216570 | 64248805 |
Atrioventricular block | 23.46 | 12.18 | 30 | 33327 | 11985 | 64453390 |
Rectal polyp | 23.40 | 12.18 | 12 | 33345 | 1272 | 64464103 |
Rash maculo-papular | 23.25 | 12.18 | 65 | 33292 | 46961 | 64418414 |
Renal failure | 23.08 | 12.18 | 167 | 33190 | 181521 | 64283854 |
Electrolyte imbalance | 22.53 | 12.18 | 44 | 33313 | 25199 | 64440176 |
Tumour invasion | 22.38 | 12.18 | 8 | 33349 | 347 | 64465028 |
Hypoglycaemia | 22.36 | 12.18 | 99 | 33258 | 89793 | 64375582 |
Eosinophilia | 22.24 | 12.18 | 56 | 33301 | 38020 | 64427355 |
Pericarditis | 22.21 | 12.18 | 3 | 33354 | 62513 | 64402862 |
Cholestasis | 22.16 | 12.18 | 62 | 33295 | 44810 | 64420565 |
Hyperlactacidaemia | 22.01 | 12.18 | 19 | 33338 | 4825 | 64460550 |
Ischaemic stroke | 21.66 | 12.18 | 47 | 33310 | 28988 | 64436387 |
Gastrointestinal ischaemia | 21.47 | 12.18 | 8 | 33349 | 391 | 64464984 |
Pemphigus | 21.36 | 12.18 | 3 | 33354 | 60698 | 64404677 |
Bundle branch block left | 21.10 | 12.18 | 26 | 33331 | 10008 | 64455367 |
Swollen tongue | 21.04 | 12.18 | 52 | 33305 | 34902 | 64430473 |
Osmotic demyelination syndrome | 20.98 | 12.18 | 11 | 33346 | 1220 | 64464155 |
Glycosylated haemoglobin increased | 20.90 | 12.18 | 33 | 33324 | 15986 | 64449389 |
Consciousness fluctuating | 20.89 | 12.18 | 12 | 33345 | 1593 | 64463782 |
Renal artery restenosis | 20.73 | 12.18 | 4 | 33353 | 12 | 64465363 |
Renal artery stenosis | 20.73 | 12.18 | 15 | 33342 | 2954 | 64462421 |
Hypovolaemic shock | 20.62 | 12.18 | 26 | 33331 | 10240 | 64455135 |
Pneumonia | 20.46 | 12.18 | 188 | 33169 | 559388 | 63905987 |
Gravitational oedema | 20.43 | 12.18 | 12 | 33345 | 1660 | 64463715 |
Renal impairment | 20.06 | 12.18 | 129 | 33228 | 134888 | 64330487 |
Central nervous system lupus | 20.05 | 12.18 | 7 | 33350 | 283 | 64465092 |
Injection site erythema | 19.78 | 12.18 | 6 | 33351 | 70794 | 64394581 |
Helicobacter test positive | 19.64 | 12.18 | 10 | 33347 | 1044 | 64464331 |
Mental status changes | 19.37 | 12.18 | 4 | 33353 | 61158 | 64404217 |
Haematocrit increased | 19.13 | 12.18 | 15 | 33342 | 3330 | 64462045 |
Psychomotor retardation | 19.08 | 12.18 | 18 | 33339 | 5125 | 64460250 |
Mucocutaneous haemorrhage | 18.99 | 12.18 | 6 | 33351 | 177 | 64465198 |
Nocturia | 18.90 | 12.18 | 26 | 33331 | 11139 | 64454236 |
Urine albumin/creatinine ratio increased | 18.81 | 12.18 | 7 | 33350 | 341 | 64465034 |
Swelling | 18.61 | 12.18 | 34 | 33323 | 160184 | 64305191 |
Paramnesia | 18.36 | 12.18 | 4 | 33353 | 25 | 64465350 |
Pyrexia | 18.19 | 12.18 | 193 | 33164 | 558451 | 63906924 |
Malaise | 17.89 | 12.18 | 296 | 33061 | 395951 | 64069424 |
Ventricular flutter | 17.72 | 12.18 | 5 | 33352 | 99 | 64465276 |
Pain | 17.71 | 12.18 | 192 | 33165 | 553319 | 63912056 |
Hypouricaemia | 17.69 | 12.18 | 7 | 33350 | 403 | 64464972 |
Hypovolaemia | 17.64 | 12.18 | 30 | 33327 | 15456 | 64449919 |
Stevens-Johnson syndrome | 17.58 | 12.18 | 48 | 33309 | 34201 | 64431174 |
Sensitisation | 17.49 | 12.18 | 11 | 33346 | 1720 | 64463655 |
Platelet count decreased | 17.41 | 12.18 | 38 | 33319 | 167673 | 64297702 |
Blood electrolytes abnormal | 17.15 | 12.18 | 11 | 33346 | 1780 | 64463595 |
Arterial stenosis | 17.08 | 12.18 | 10 | 33347 | 1375 | 64464000 |
Renal artery arteriosclerosis | 17.08 | 12.18 | 4 | 33353 | 36 | 64465339 |
Haemoglobin increased | 17.04 | 12.18 | 17 | 33340 | 5184 | 64460191 |
Pancreatic neoplasm | 17.01 | 12.18 | 10 | 33347 | 1385 | 64463990 |
Oedema genital | 16.85 | 12.18 | 7 | 33350 | 457 | 64464918 |
Lip swelling | 16.66 | 12.18 | 45 | 33312 | 31862 | 64433513 |
Injection site pain | 16.48 | 12.18 | 20 | 33337 | 111388 | 64353987 |
Rhabdomyolysis | 16.41 | 12.18 | 92 | 33265 | 91634 | 64373741 |
Change of bowel habit | 16.30 | 12.18 | 12 | 33345 | 2426 | 64462949 |
Angular cheilitis | 16.30 | 12.18 | 7 | 33350 | 497 | 64464878 |
Anaemia megaloblastic | 16.26 | 12.18 | 7 | 33350 | 500 | 64464875 |
Nail pitting | 16.22 | 12.18 | 6 | 33351 | 287 | 64465088 |
Ventricular extrasystoles | 16.19 | 12.18 | 31 | 33326 | 17498 | 64447877 |
Glomerular filtration rate decreased | 16.13 | 12.18 | 33 | 33324 | 19539 | 64445836 |
Gingival hypoplasia | 16.10 | 12.18 | 3 | 33354 | 7 | 64465368 |
Product use issue | 16.06 | 12.18 | 34 | 33323 | 151681 | 64313694 |
Bundle branch block right | 16.03 | 12.18 | 23 | 33334 | 10246 | 64455129 |
Fatigue | 15.97 | 12.18 | 282 | 33075 | 748448 | 63716927 |
Pemphigoid | 15.92 | 12.18 | 26 | 33331 | 12960 | 64452415 |
Glucose tolerance impaired | 15.70 | 12.18 | 18 | 33339 | 6425 | 64458950 |
External ear pain | 15.55 | 12.18 | 3 | 33354 | 9 | 64465366 |
Hospitalisation | 15.33 | 12.18 | 10 | 33347 | 75197 | 64390178 |
Contraindicated product administered | 15.28 | 12.18 | 20 | 33337 | 107809 | 64357566 |
Convulsive threshold lowered | 15.23 | 12.18 | 8 | 33349 | 891 | 64464484 |
Product prescribing issue | 15.09 | 12.18 | 11 | 33346 | 2190 | 64463185 |
Gingival hypertrophy | 15.03 | 12.18 | 12 | 33345 | 2735 | 64462640 |
Proctalgia | 14.95 | 12.18 | 19 | 33338 | 7540 | 64457835 |
Glycosylated haemoglobin decreased | 14.95 | 12.18 | 7 | 33350 | 609 | 64464766 |
Platelet dysfunction | 14.94 | 12.18 | 6 | 33351 | 359 | 64465016 |
Injection site reaction | 14.89 | 12.18 | 3 | 33354 | 46661 | 64418714 |
Jaundice | 14.88 | 12.18 | 57 | 33300 | 48455 | 64416920 |
Drug hypersensitivity | 14.74 | 12.18 | 68 | 33289 | 237747 | 64227628 |
Product use in unapproved indication | 14.52 | 12.18 | 45 | 33312 | 176573 | 64288802 |
Inclusion body myositis | 14.51 | 12.18 | 3 | 33354 | 14 | 64465361 |
Protrusion tongue | 14.46 | 12.18 | 6 | 33351 | 391 | 64464984 |
Proteinuria | 14.37 | 12.18 | 39 | 33318 | 27684 | 64437691 |
Fear of eating | 14.20 | 12.18 | 6 | 33351 | 409 | 64464966 |
Iron deficiency | 14.13 | 12.18 | 18 | 33339 | 7159 | 64458216 |
Wrong technique in product usage process | 14.13 | 12.18 | 8 | 33349 | 64966 | 64400409 |
Disease progression | 13.97 | 12.18 | 33 | 33324 | 141647 | 64323728 |
Ventricular fibrillation | 13.84 | 12.18 | 35 | 33322 | 23825 | 64441550 |
Spinal pain | 13.78 | 12.18 | 24 | 33333 | 12597 | 64452778 |
Alopecia | 13.77 | 12.18 | 42 | 33315 | 165648 | 64299727 |
Polydipsia | 13.74 | 12.18 | 16 | 33341 | 5805 | 64459570 |
Hypocalcaemia | 13.59 | 12.18 | 50 | 33307 | 41703 | 64423672 |
Vulvovaginal inflammation | 13.36 | 12.18 | 6 | 33351 | 474 | 64464901 |
Hypocalciuria | 13.35 | 12.18 | 3 | 33354 | 22 | 64465353 |
Chronic gastritis | 13.30 | 12.18 | 12 | 33345 | 3228 | 64462147 |
Abdominal discomfort | 13.25 | 12.18 | 49 | 33308 | 182273 | 64283102 |
Migraine | 13.23 | 12.18 | 8 | 33349 | 62669 | 64402706 |
Stomatitis | 12.96 | 12.18 | 23 | 33334 | 109582 | 64355793 |
Ephelides | 12.86 | 12.18 | 4 | 33353 | 112 | 64465263 |
Red blood cell sedimentation rate abnormal | 12.86 | 12.18 | 27 | 33330 | 16279 | 64449096 |
Brain stem haematoma | 12.63 | 12.18 | 4 | 33353 | 119 | 64465256 |
Vomiting | 12.48 | 12.18 | 373 | 32984 | 550744 | 63914631 |
Angina pectoris | 12.25 | 12.18 | 51 | 33306 | 45030 | 64420345 |
Pain in jaw | 12.23 | 12.18 | 3 | 33354 | 40752 | 64424623 |
None
Source | Code | Description |
---|---|---|
ATC | C03BA11 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, EXCL. THIAZIDES Sulfonamides, plain |
ATC | C09BX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C10BX13 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA PE | N0000175359 | Increased Diuresis |
FDA EPC | N0000175420 | Thiazide-like Diuretic |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004232 | Diuretics |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D045283 | Natriuretic Agents |
MeSH PA | D049993 | Sodium Chloride Symporter Inhibitors |
CHEBI has role | CHEBI:35498 | diuretics |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Edema | indication | 267038008 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypokalemia | contraindication | 43339004 | |
Sympathectomy | contraindication | 57071006 | |
Acute nephropathy | contraindication | 58574008 | |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Oliguria | contraindication | 83128009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Disease of liver | contraindication | 235856003 | DOID:409 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.53 | acidic |
pKa2 | 9.54 | acidic |
pKa3 | 5.52 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 12 member 3 | Transporter | INHIBITOR | A2 | 7.54 | WOMBAT-PK | CHEMBL | |||
Carbonic anhydrase 1 | Enzyme | Kd | 5 | CHEMBL | |||||
Carbonic anhydrase 4 | Enzyme | Ki | 6.67 | CHEMBL | |||||
Carbonic anhydrase 9 | Enzyme | Ki | 7.44 | CHEMBL | |||||
Carbonic anhydrase 12 | Enzyme | Ki | 8 | CHEMBL | |||||
Potassium voltage-gated channel subfamily KQT member 1 | Ion channel | WOMBAT-PK | |||||||
Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 6.05 | CHEMBL | |||||
Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 6.56 | CHEMBL | |||||
Carbonic anhydrase 7 | Enzyme | Ki | 9.64 | CHEMBL | |||||
Carbonic anhydrase 6 | Enzyme | Kd | 6.60 | CHEMBL | |||||
Carbonic anhydrase 14 | Enzyme | Ki | 5.31 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | Kd | 6.70 | CHEMBL | |||||
Carbonic anhydrase 13 | Enzyme | Kd | 7 | CHEMBL | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.54 | DRUG MATRIX | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 7.89 | CHEMBL |
ID | Source |
---|---|
4018746 | VUID |
N0000147050 | NUI |
D00345 | KEGG_DRUG |
180004-24-4 | SECONDARY_CAS_RN |
4018746 | VANDF |
C0021186 | UMLSCUI |
CHEBI:5893 | CHEBI |
BL1 | PDB_CHEM_ID |
CHEMBL406 | ChEMBL_ID |
DB00808 | DRUGBANK_ID |
D007190 | MESH_DESCRIPTOR_UI |
3702 | PUBCHEM_CID |
7203 | IUPHAR_LIGAND_ID |
3333 | INN_ID |
F089I0511L | UNII |
5764 | RXNORM |
2360 | MMSL |
4873 | MMSL |
d00260 | MMSL |
002313 | NDDF |
387419003 | SNOMEDCT_US |
725661001 | SNOMEDCT_US |
74213004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2571 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2597 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-576 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-348 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-349 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-024 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-025 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62559-510 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62559-511 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1953 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1953 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1954 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1954 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68151-1294 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68788-7247 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71335-1541 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |