indapamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diuretics, sulfamoylbenzoic acid derivatives | 1433 | 26807-65-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 2.50 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.59 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 7 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.20 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 6, 1983 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hyponatraemia | 1351.44 | 13.68 | 728 | 24851 | 111172 | 63352271 |
| Hypokalaemia | 543.03 | 13.68 | 398 | 25181 | 103406 | 63360037 |
| Acute kidney injury | 234.56 | 13.68 | 397 | 25182 | 263018 | 63200425 |
| Inappropriate antidiuretic hormone secretion | 186.77 | 13.68 | 101 | 25478 | 15361 | 63448082 |
| Drug interaction | 118.15 | 13.68 | 275 | 25304 | 228856 | 63234587 |
| Hypomagnesaemia | 110.39 | 13.68 | 92 | 25487 | 28645 | 63434798 |
| Confusional state | 109.30 | 13.68 | 272 | 25307 | 236108 | 63227335 |
| Hypochloraemia | 109.10 | 13.68 | 38 | 25541 | 1971 | 63461472 |
| Burning mouth syndrome | 85.68 | 13.68 | 23 | 25556 | 488 | 63462955 |
| Hyponatraemic seizure | 84.10 | 13.68 | 22 | 25557 | 421 | 63463022 |
| Conjoined twins | 73.42 | 13.68 | 18 | 25561 | 262 | 63463181 |
| Rectal polyp | 73.35 | 13.68 | 25 | 25554 | 1214 | 63462229 |
| Blood pressure increased | 71.17 | 13.68 | 183 | 25396 | 161879 | 63301564 |
| Torsade de pointes | 69.14 | 13.68 | 51 | 25528 | 13300 | 63450143 |
| Maternal exposure during pregnancy | 66.64 | 13.68 | 6 | 25573 | 220056 | 63243387 |
| Labile hypertension | 63.58 | 13.68 | 18 | 25561 | 468 | 63462975 |
| Pemphigus | 58.45 | 13.68 | 4 | 25575 | 183722 | 63279721 |
| Drug ineffective | 58.33 | 13.68 | 221 | 25358 | 1044544 | 62418899 |
| Change of bowel habit | 56.14 | 13.68 | 24 | 25555 | 2169 | 63461274 |
| Congenital bladder anomaly | 54.25 | 13.68 | 13 | 25566 | 171 | 63463272 |
| Intestinal malrotation | 53.93 | 13.68 | 15 | 25564 | 365 | 63463078 |
| Urachal abnormality | 53.70 | 13.68 | 13 | 25566 | 179 | 63463264 |
| Electrocardiogram QT prolonged | 53.09 | 13.68 | 90 | 25489 | 59440 | 63404003 |
| Persistent cloaca | 52.85 | 13.68 | 13 | 25566 | 192 | 63463251 |
| Intestinal haemorrhage | 51.72 | 13.68 | 27 | 25552 | 3820 | 63459623 |
| Off label use | 50.88 | 13.68 | 124 | 25455 | 674338 | 62789105 |
| Proctalgia | 47.49 | 13.68 | 30 | 25549 | 6080 | 63457363 |
| Atrial fibrillation | 47.39 | 13.68 | 128 | 25451 | 116508 | 63346935 |
| Death | 46.94 | 13.68 | 49 | 25530 | 374332 | 63089111 |
| Sensitisation | 46.19 | 13.68 | 24 | 25555 | 3362 | 63460081 |
| Left ventricular hypertrophy | 46.14 | 13.68 | 28 | 25551 | 5287 | 63458156 |
| Infection | 45.01 | 13.68 | 18 | 25561 | 229155 | 63234288 |
| Product packaging confusion | 44.50 | 13.68 | 11 | 25568 | 166 | 63463277 |
| Urine odour abnormal | 43.82 | 13.68 | 29 | 25550 | 6360 | 63457083 |
| Vessel puncture site haemorrhage | 42.57 | 13.68 | 10 | 25569 | 120 | 63463323 |
| Arthropathy | 42.09 | 13.68 | 21 | 25558 | 234771 | 63228672 |
| Dehydration | 41.80 | 13.68 | 159 | 25420 | 173195 | 63290248 |
| Alopecia | 41.39 | 13.68 | 45 | 25534 | 337491 | 63125952 |
| Infusion related reaction | 41.04 | 13.68 | 24 | 25555 | 245497 | 63217946 |
| Central nervous system lupus | 41.03 | 13.68 | 13 | 25566 | 501 | 63462942 |
| Furuncle | 40.72 | 13.68 | 28 | 25551 | 6538 | 63456905 |
| Exposure during pregnancy | 40.39 | 13.68 | 7 | 25572 | 155540 | 63307903 |
| Sprue-like enteropathy | 40.14 | 13.68 | 14 | 25565 | 729 | 63462714 |
| Blood sodium decreased | 39.81 | 13.68 | 49 | 25530 | 24203 | 63439240 |
| Injection site discomfort | 39.19 | 13.68 | 24 | 25555 | 4606 | 63458837 |
| Needle issue | 37.33 | 13.68 | 32 | 25547 | 10344 | 63453099 |
| Dysuria | 36.91 | 13.68 | 56 | 25523 | 33682 | 63429761 |
| Glossodynia | 36.87 | 13.68 | 13 | 25566 | 178863 | 63284580 |
| Contraindicated product administered | 36.76 | 13.68 | 21 | 25558 | 217627 | 63245816 |
| Bradycardia | 36.65 | 13.68 | 87 | 25492 | 73140 | 63390303 |
| Duodenal ulcer | 36.54 | 13.68 | 28 | 25551 | 7728 | 63455715 |
| Treatment failure | 35.38 | 13.68 | 18 | 25561 | 199025 | 63264418 |
| Fall | 35.06 | 13.68 | 274 | 25305 | 392060 | 63071383 |
| Product dose omission issue | 34.97 | 13.68 | 26 | 25553 | 234287 | 63229156 |
| Hypertensive angiopathy | 34.95 | 13.68 | 8 | 25571 | 85 | 63463358 |
| Urine abnormality | 34.52 | 13.68 | 26 | 25553 | 6993 | 63456450 |
| Jaundice | 34.07 | 13.68 | 50 | 25529 | 29201 | 63434242 |
| Orthostatic hypotension | 34.01 | 13.68 | 56 | 25523 | 36104 | 63427339 |
| Polyp | 33.96 | 13.68 | 25 | 25554 | 6496 | 63456947 |
| Nasal mucosal disorder | 33.90 | 13.68 | 11 | 25568 | 458 | 63462985 |
| Renin increased | 33.80 | 13.68 | 9 | 25570 | 185 | 63463258 |
| Metabolic acidosis | 33.57 | 13.68 | 63 | 25516 | 45006 | 63418437 |
| Swelling | 33.42 | 13.68 | 37 | 25542 | 275341 | 63188102 |
| Systemic lupus erythematosus | 32.73 | 13.68 | 22 | 25557 | 208896 | 63254547 |
| Hyperlactacidaemia | 32.70 | 13.68 | 18 | 25561 | 2831 | 63460612 |
| Frustration tolerance decreased | 32.42 | 13.68 | 25 | 25554 | 6963 | 63456480 |
| Croup infectious | 32.24 | 13.68 | 11 | 25568 | 536 | 63462907 |
| Urinary incontinence | 32.04 | 13.68 | 51 | 25528 | 31963 | 63431480 |
| Postoperative wound infection | 31.99 | 13.68 | 30 | 25549 | 10895 | 63452548 |
| Discomfort | 31.48 | 13.68 | 14 | 25565 | 167360 | 63296083 |
| Dyslipidaemia | 31.17 | 13.68 | 25 | 25554 | 7368 | 63456075 |
| Eosinophilia | 31.11 | 13.68 | 42 | 25537 | 22714 | 63440729 |
| Bladder disorder | 30.99 | 13.68 | 27 | 25552 | 8919 | 63454524 |
| Hepatic enzyme increased | 30.77 | 13.68 | 22 | 25557 | 202306 | 63261137 |
| Blood urea increased | 30.59 | 13.68 | 45 | 25534 | 26334 | 63437109 |
| Renal artery stenosis | 30.33 | 13.68 | 15 | 25564 | 1894 | 63461549 |
| Hypotension | 29.87 | 13.68 | 200 | 25379 | 272404 | 63191039 |
| Diabetes mellitus | 29.78 | 13.68 | 68 | 25511 | 55742 | 63407701 |
| Peripheral coldness | 29.27 | 13.68 | 30 | 25549 | 12135 | 63451308 |
| Mass | 29.20 | 13.68 | 32 | 25547 | 13968 | 63449475 |
| Renal impairment | 29.13 | 13.68 | 90 | 25489 | 88265 | 63375178 |
| Wound | 28.65 | 13.68 | 15 | 25564 | 163248 | 63300195 |
| Abdominal discomfort | 28.25 | 13.68 | 54 | 25525 | 320831 | 63142612 |
| Lactic acidosis | 27.87 | 13.68 | 53 | 25526 | 38234 | 63425209 |
| Gravitational oedema | 26.89 | 13.68 | 12 | 25567 | 1202 | 63462241 |
| Glomerular filtration rate decreased | 26.79 | 13.68 | 30 | 25549 | 13411 | 63450032 |
| Hypouricaemia | 26.10 | 13.68 | 7 | 25572 | 148 | 63463295 |
| Diabetic metabolic decompensation | 25.88 | 13.68 | 13 | 25566 | 1697 | 63461746 |
| Ischaemic stroke | 25.86 | 13.68 | 34 | 25545 | 17923 | 63445520 |
| Blood pressure inadequately controlled | 25.73 | 13.68 | 19 | 25560 | 4959 | 63458484 |
| Butterfly rash | 25.44 | 13.68 | 13 | 25566 | 1760 | 63461683 |
| Blood electrolytes abnormal | 25.16 | 13.68 | 11 | 25568 | 1050 | 63462393 |
| Angioedema | 25.10 | 13.68 | 58 | 25521 | 47907 | 63415536 |
| Oliguria | 24.77 | 13.68 | 24 | 25555 | 9077 | 63454366 |
| Convulsive threshold lowered | 24.40 | 13.68 | 8 | 25571 | 344 | 63463099 |
| Mucocutaneous haemorrhage | 24.12 | 13.68 | 6 | 25573 | 93 | 63463350 |
| Sinusitis | 23.79 | 13.68 | 34 | 25545 | 226619 | 63236824 |
| Impaired healing | 23.76 | 13.68 | 6 | 25573 | 102536 | 63360907 |
| Glomerular filtration rate increased | 23.56 | 13.68 | 10 | 25569 | 888 | 63462555 |
| Presyncope | 23.44 | 13.68 | 41 | 25538 | 27744 | 63435699 |
| Circulatory collapse | 23.41 | 13.68 | 36 | 25543 | 21902 | 63441541 |
| Platelet dysfunction | 23.33 | 13.68 | 6 | 25573 | 107 | 63463336 |
| Failure to suspend medication | 22.90 | 13.68 | 5 | 25574 | 42 | 63463401 |
| Paramnesia | 22.88 | 13.68 | 4 | 25575 | 8 | 63463435 |
| Psychomotor retardation | 22.82 | 13.68 | 16 | 25563 | 3854 | 63459589 |
| Heart rate decreased | 22.65 | 13.68 | 54 | 25525 | 45506 | 63417937 |
| Thyroid disorder | 22.29 | 13.68 | 29 | 25550 | 15133 | 63448310 |
| Lupus nephritis | 22.21 | 13.68 | 14 | 25565 | 2825 | 63460618 |
| Migraine | 22.18 | 13.68 | 7 | 25572 | 103339 | 63360104 |
| Malaise | 21.94 | 13.68 | 260 | 25319 | 415694 | 63047749 |
| Rhabdomyolysis | 21.75 | 13.68 | 52 | 25527 | 43899 | 63419544 |
| Hypoglycaemia | 21.51 | 13.68 | 63 | 25516 | 60002 | 63403441 |
| Dizziness | 21.49 | 13.68 | 266 | 25313 | 429659 | 63033784 |
| Urine albumin/creatinine ratio increased | 21.33 | 13.68 | 7 | 25572 | 302 | 63463141 |
| Blood pressure systolic increased | 21.25 | 13.68 | 54 | 25525 | 47343 | 63416100 |
| Metabolic alkalosis | 21.25 | 13.68 | 14 | 25565 | 3047 | 63460396 |
| Vascular resistance systemic | 21.04 | 13.68 | 4 | 25575 | 15 | 63463428 |
| Syncope | 20.75 | 13.68 | 98 | 25481 | 117287 | 63346156 |
| Fatigue | 20.64 | 13.68 | 244 | 25335 | 887784 | 62575659 |
| Retinal detachment | 20.64 | 13.68 | 18 | 25561 | 5951 | 63457492 |
| Glycosylated haemoglobin increased | 20.26 | 13.68 | 25 | 25554 | 12373 | 63451070 |
| Oedema peripheral | 20.11 | 13.68 | 138 | 25441 | 189373 | 63274070 |
| Anuria | 20.02 | 13.68 | 25 | 25554 | 12526 | 63450917 |
| Blood creatine phosphokinase increased | 19.58 | 13.68 | 40 | 25539 | 30390 | 63433053 |
| Lung neoplasm malignant | 19.26 | 13.68 | 31 | 25548 | 19602 | 63443841 |
| Spinal pain | 19.11 | 13.68 | 25 | 25554 | 13114 | 63450329 |
| Rash | 19.09 | 13.68 | 140 | 25439 | 560731 | 62902712 |
| Myalgia | 18.81 | 13.68 | 112 | 25467 | 146417 | 63317026 |
| Drug intolerance | 18.59 | 13.68 | 63 | 25516 | 308598 | 63154845 |
| Poor dental condition | 18.46 | 13.68 | 7 | 25572 | 463 | 63462980 |
| Vomiting | 18.41 | 13.68 | 322 | 25257 | 559295 | 62904148 |
| Therapeutic product effect decreased | 18.34 | 13.68 | 31 | 25548 | 193156 | 63270287 |
| Protein urine present | 18.29 | 13.68 | 17 | 25562 | 6103 | 63457340 |
| Blood creatinine increased | 18.28 | 13.68 | 77 | 25502 | 87767 | 63375676 |
| Pyelonephritis acute | 18.11 | 13.68 | 15 | 25564 | 4626 | 63458817 |
| Lower respiratory tract infection | 18.08 | 13.68 | 16 | 25563 | 132291 | 63331152 |
| Hypovolaemic shock | 18.01 | 13.68 | 17 | 25562 | 6224 | 63457219 |
| Nephropathy | 17.78 | 13.68 | 17 | 25562 | 6324 | 63457119 |
| Impaired work ability | 17.70 | 13.68 | 28 | 25551 | 17447 | 63445996 |
| Iron deficiency | 17.70 | 13.68 | 18 | 25561 | 7212 | 63456231 |
| Cardiac failure | 17.67 | 13.68 | 77 | 25502 | 89065 | 63374378 |
| Vulvovaginal inflammation | 17.65 | 13.68 | 8 | 25571 | 831 | 63462612 |
| Acetonaemia | 17.59 | 13.68 | 5 | 25574 | 132 | 63463311 |
| Hepatitis D | 17.43 | 13.68 | 4 | 25575 | 43 | 63463400 |
| Electrocardiogram ST-T segment abnormal | 17.34 | 13.68 | 6 | 25573 | 305 | 63463138 |
| Hypotonia | 17.28 | 13.68 | 20 | 25559 | 9265 | 63454178 |
| Weight increased | 17.27 | 13.68 | 51 | 25528 | 260741 | 63202702 |
| Exostosis | 17.25 | 13.68 | 28 | 25551 | 17834 | 63445609 |
| Labelled drug-drug interaction medication error | 17.21 | 13.68 | 24 | 25555 | 13375 | 63450068 |
| Spur cell anaemia | 17.19 | 13.68 | 4 | 25575 | 46 | 63463397 |
| Drug hypersensitivity | 17.00 | 13.68 | 66 | 25513 | 310621 | 63152822 |
| Disorientation | 16.71 | 13.68 | 44 | 25535 | 39408 | 63424035 |
| Serratia infection | 16.52 | 13.68 | 8 | 25571 | 965 | 63462478 |
| Tinnitus | 16.40 | 13.68 | 41 | 25538 | 35587 | 63427856 |
| Protrusion tongue | 16.32 | 13.68 | 6 | 25573 | 364 | 63463079 |
| Stevens-Johnson syndrome | 16.29 | 13.68 | 33 | 25546 | 24917 | 63438526 |
| Leukocyturia | 16.20 | 13.68 | 9 | 25570 | 1440 | 63462003 |
| Nail injury | 16.17 | 13.68 | 7 | 25572 | 652 | 63462791 |
| Inclusion body myositis | 16.06 | 13.68 | 3 | 25576 | 10 | 63463433 |
| Fear of eating | 15.98 | 13.68 | 6 | 25573 | 386 | 63463057 |
| Hypocalciuria | 15.84 | 13.68 | 3 | 25576 | 11 | 63463432 |
| Intracranial haematoma | 15.72 | 13.68 | 6 | 25573 | 404 | 63463039 |
| Limb discomfort | 15.62 | 13.68 | 36 | 25543 | 29680 | 63433763 |
| Arrhythmia | 15.61 | 13.68 | 42 | 25537 | 38098 | 63425345 |
| Urine output decreased | 15.56 | 13.68 | 21 | 25558 | 11349 | 63452094 |
| Transplant dysfunction | 15.47 | 13.68 | 14 | 25565 | 4858 | 63458585 |
| Blood glucose decreased | 15.24 | 13.68 | 29 | 25550 | 20923 | 63442520 |
| Pain | 15.13 | 13.68 | 209 | 25370 | 740419 | 62723024 |
| Angle closure glaucoma | 15.04 | 13.68 | 10 | 25569 | 2209 | 63461234 |
| Chronic gastritis | 15.04 | 13.68 | 11 | 25568 | 2830 | 63460613 |
| Haematoma | 14.92 | 13.68 | 39 | 25540 | 34781 | 63428662 |
| Blood pressure abnormal | 14.91 | 13.68 | 24 | 25555 | 15174 | 63448269 |
| Hypersensitivity | 14.87 | 13.68 | 64 | 25515 | 292621 | 63170822 |
| Gallbladder disorder | 14.86 | 13.68 | 27 | 25552 | 18815 | 63444628 |
| COVID-19 pneumonia | 14.72 | 13.68 | 23 | 25556 | 14186 | 63449257 |
| Euglycaemic diabetic ketoacidosis | 14.60 | 13.68 | 12 | 25567 | 3662 | 63459781 |
| Renal failure | 14.51 | 13.68 | 89 | 25490 | 117563 | 63345880 |
| Extranodal marginal zone B-cell lymphoma (MALT type) | 14.46 | 13.68 | 6 | 25573 | 503 | 63462940 |
| Decreased appetite | 14.13 | 13.68 | 159 | 25420 | 250893 | 63212550 |
| Blood glucose increased | 14.12 | 13.68 | 69 | 25510 | 83687 | 63379756 |
| Injection site erythema | 14.06 | 13.68 | 8 | 25571 | 83166 | 63380277 |
| Neglect of personal appearance | 14.02 | 13.68 | 4 | 25575 | 107 | 63463336 |
| Lymphocytic infiltration | 14.01 | 13.68 | 7 | 25572 | 903 | 63462540 |
| Red blood cell sedimentation rate abnormal | 13.92 | 13.68 | 27 | 25552 | 19755 | 63443688 |
| Injection site mass | 13.79 | 13.68 | 26 | 25553 | 18630 | 63444813 |
| Normocytic anaemia | 13.78 | 13.68 | 9 | 25570 | 1931 | 63461512 |
| Drug abuse | 13.73 | 13.68 | 6 | 25573 | 72512 | 63390931 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hyponatraemia | 274.54 | 13.88 | 267 | 17158 | 82424 | 34857082 |
| Hypokalaemia | 223.74 | 13.88 | 204 | 17221 | 58010 | 34881496 |
| Acute kidney injury | 135.90 | 13.88 | 395 | 17030 | 304593 | 34634913 |
| Death | 82.95 | 13.88 | 48 | 17377 | 398001 | 34541505 |
| Hypomagnesaemia | 78.79 | 13.88 | 74 | 17351 | 21777 | 34917729 |
| Drug interaction | 75.91 | 13.88 | 266 | 17159 | 225680 | 34713826 |
| Bradycardia | 45.85 | 13.88 | 110 | 17315 | 75308 | 34864198 |
| Tachyarrhythmia | 45.27 | 13.88 | 26 | 17399 | 3582 | 34935924 |
| Hyperkalaemia | 43.03 | 13.88 | 102 | 17323 | 69287 | 34870219 |
| Atrial fibrillation | 41.74 | 13.88 | 145 | 17280 | 122248 | 34817258 |
| Obesity | 41.48 | 13.88 | 41 | 17384 | 12837 | 34926669 |
| Hypoosmolar state | 40.31 | 13.88 | 10 | 17415 | 122 | 34939384 |
| Drug abuse | 38.06 | 13.88 | 3 | 17422 | 99093 | 34840413 |
| Postictal paralysis | 37.82 | 13.88 | 11 | 17414 | 253 | 34939253 |
| Drug ineffective | 35.90 | 13.88 | 113 | 17312 | 456638 | 34482868 |
| Mucosal dryness | 35.60 | 13.88 | 16 | 17409 | 1315 | 34938191 |
| Off label use | 34.95 | 13.88 | 101 | 17324 | 419423 | 34520083 |
| Syncope | 34.39 | 13.88 | 112 | 17313 | 91339 | 34848167 |
| Left atrial dilatation | 32.25 | 13.88 | 17 | 17408 | 1979 | 34937527 |
| Lactic acidosis | 31.89 | 13.88 | 60 | 17365 | 34712 | 34904794 |
| Oedema peripheral | 30.98 | 13.88 | 130 | 17295 | 119682 | 34819824 |
| Drug dispensed to wrong patient | 30.41 | 13.88 | 11 | 17414 | 513 | 34938993 |
| Herbal interaction | 29.88 | 13.88 | 10 | 17415 | 369 | 34939137 |
| Sleep disorder due to a general medical condition | 29.73 | 13.88 | 23 | 17402 | 5198 | 34934308 |
| Dyspnoea exertional | 29.43 | 13.88 | 66 | 17359 | 43213 | 34896293 |
| Haematocrit increased | 28.59 | 13.88 | 16 | 17409 | 2097 | 34937409 |
| Dizziness | 28.28 | 13.88 | 196 | 17229 | 218325 | 34721181 |
| Varicose vein | 26.05 | 13.88 | 13 | 17412 | 1350 | 34938156 |
| Endoscopy upper gastrointestinal tract abnormal | 25.45 | 13.88 | 6 | 17419 | 58 | 34939448 |
| Hypotension | 25.34 | 13.88 | 193 | 17232 | 221456 | 34718050 |
| Febrile neutropenia | 25.00 | 13.88 | 19 | 17406 | 136830 | 34802676 |
| Wheezing | 24.72 | 13.88 | 60 | 17365 | 41342 | 34898164 |
| Myalgia | 24.71 | 13.88 | 95 | 17330 | 84015 | 34855491 |
| Consciousness fluctuating | 24.71 | 13.88 | 12 | 17413 | 1175 | 34938331 |
| Pancreatic neoplasm | 24.55 | 13.88 | 11 | 17414 | 897 | 34938609 |
| Diabetic foot | 24.49 | 13.88 | 16 | 17409 | 2772 | 34936734 |
| Haemoglobin increased | 23.86 | 13.88 | 17 | 17408 | 3392 | 34936114 |
| Tumour invasion | 23.68 | 13.88 | 8 | 17417 | 304 | 34939202 |
| Nail pitting | 23.61 | 13.88 | 8 | 17417 | 307 | 34939199 |
| Renal artery arteriosclerosis | 23.03 | 13.88 | 5 | 17420 | 32 | 34939474 |
| Electrolyte imbalance | 23.01 | 13.88 | 32 | 17393 | 14380 | 34925126 |
| Stenosis | 22.26 | 13.88 | 12 | 17413 | 1461 | 34938045 |
| Gastrointestinal ischaemia | 22.21 | 13.88 | 7 | 17418 | 213 | 34939293 |
| Polyuria | 21.70 | 13.88 | 24 | 17401 | 8550 | 34930956 |
| Rhabdomyolysis | 21.69 | 13.88 | 79 | 17346 | 68084 | 34871422 |
| Cholestasis | 21.67 | 13.88 | 44 | 17381 | 26904 | 34912602 |
| Renal artery restenosis | 20.88 | 13.88 | 4 | 17421 | 12 | 34939494 |
| Onychophagia | 19.93 | 13.88 | 5 | 17420 | 64 | 34939442 |
| Inappropriate antidiuretic hormone secretion | 19.89 | 13.88 | 28 | 17397 | 12725 | 34926781 |
| Peripheral artery haematoma | 19.52 | 13.88 | 5 | 17420 | 70 | 34939436 |
| Angular cheilitis | 19.34 | 13.88 | 6 | 17419 | 173 | 34939333 |
| Lip swelling | 18.96 | 13.88 | 31 | 17394 | 16049 | 34923457 |
| Urinary retention | 18.96 | 13.88 | 50 | 17375 | 36238 | 34903268 |
| Bundle branch block right | 18.95 | 13.88 | 21 | 17404 | 7495 | 34932011 |
| Hypoparathyroidism | 18.53 | 13.88 | 8 | 17417 | 597 | 34938909 |
| Ventricular flutter | 18.51 | 13.88 | 5 | 17420 | 87 | 34939419 |
| Glycosylated haemoglobin decreased | 18.33 | 13.88 | 7 | 17418 | 380 | 34939126 |
| Renal pain | 18.29 | 13.88 | 14 | 17411 | 3114 | 34936392 |
| Angioedema | 18.02 | 13.88 | 50 | 17375 | 37324 | 34902182 |
| Type 2 diabetes mellitus | 17.69 | 13.88 | 30 | 17395 | 16002 | 34923504 |
| Presyncope | 17.61 | 13.88 | 33 | 17392 | 19026 | 34920480 |
| Hepatic ischaemia | 17.57 | 13.88 | 7 | 17418 | 426 | 34939080 |
| Arrhythmia | 17.36 | 13.88 | 48 | 17377 | 35760 | 34903746 |
| Pneumonia | 17.29 | 13.88 | 108 | 17317 | 362519 | 34576987 |
| Skin disorder | 17.17 | 13.88 | 27 | 17398 | 13528 | 34925978 |
| Neutrophilia | 16.83 | 13.88 | 15 | 17410 | 4122 | 34935384 |
| Oedema genital | 16.33 | 13.88 | 7 | 17418 | 513 | 34938993 |
| Arterial stenosis | 16.24 | 13.88 | 9 | 17416 | 1157 | 34938349 |
| Gingival hypoplasia | 16.21 | 13.88 | 3 | 17422 | 7 | 34939499 |
| Atrioventricular block | 16.12 | 13.88 | 20 | 17405 | 8043 | 34931463 |
| Electrocardiogram T wave abnormal | 16.08 | 13.88 | 10 | 17415 | 1591 | 34937915 |
| Toxicity to various agents | 16.06 | 13.88 | 49 | 17376 | 200313 | 34739193 |
| Crepitations | 15.89 | 13.88 | 13 | 17412 | 3183 | 34936323 |
| Hypovolaemia | 15.49 | 13.88 | 21 | 17404 | 9213 | 34930293 |
| Tubulointerstitial nephritis | 15.35 | 13.88 | 33 | 17392 | 20991 | 34918515 |
| External ear pain | 14.99 | 13.88 | 3 | 17422 | 12 | 34939494 |
| Renal mass | 14.99 | 13.88 | 10 | 17415 | 1794 | 34937712 |
| Thrombocytosis | 14.95 | 13.88 | 14 | 17411 | 4098 | 34935408 |
| Choroidal effusion | 14.85 | 13.88 | 5 | 17420 | 188 | 34939318 |
| Metastases to peritoneum | 14.79 | 13.88 | 10 | 17415 | 1834 | 34937672 |
| Malaise | 14.07 | 13.88 | 148 | 17277 | 185677 | 34753829 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hyponatraemia | 1375.05 | 11.94 | 943 | 39244 | 176905 | 79527296 |
| Hypokalaemia | 690.75 | 11.94 | 575 | 39612 | 143465 | 79560736 |
| Acute kidney injury | 330.20 | 11.94 | 774 | 39413 | 518630 | 79185571 |
| Hypomagnesaemia | 193.25 | 11.94 | 172 | 40015 | 46739 | 79657462 |
| Drug interaction | 172.19 | 11.94 | 529 | 39658 | 414654 | 79289547 |
| Inappropriate antidiuretic hormone secretion | 157.73 | 11.94 | 120 | 40067 | 26193 | 79678008 |
| Death | 106.83 | 11.94 | 78 | 40109 | 566436 | 79137765 |
| Hypochloraemia | 106.32 | 11.94 | 42 | 40145 | 2473 | 79701728 |
| Completed suicide | 106.30 | 11.94 | 4 | 40183 | 245763 | 79458438 |
| Confusional state | 104.64 | 11.94 | 375 | 39812 | 317622 | 79386579 |
| Atrial fibrillation | 98.01 | 11.94 | 269 | 39918 | 197617 | 79506584 |
| Off label use | 89.37 | 11.94 | 204 | 39983 | 907011 | 78797190 |
| Burning mouth syndrome | 78.79 | 11.94 | 23 | 40164 | 530 | 79703671 |
| Hyponatraemic seizure | 78.71 | 11.94 | 23 | 40164 | 532 | 79703669 |
| Bradycardia | 70.81 | 11.94 | 188 | 39999 | 135369 | 79568832 |
| Drug ineffective | 68.35 | 11.94 | 297 | 39890 | 1080616 | 78623585 |
| Torsade de pointes | 68.20 | 11.94 | 65 | 40122 | 19247 | 79684954 |
| Rectal polyp | 60.53 | 11.94 | 25 | 40162 | 1652 | 79702549 |
| Blood pressure increased | 59.28 | 11.94 | 237 | 39950 | 211123 | 79493078 |
| Drug abuse | 57.83 | 11.94 | 7 | 40180 | 162684 | 79541517 |
| Labile hypertension | 57.44 | 11.94 | 18 | 40169 | 531 | 79703670 |
| Maternal exposure during pregnancy | 56.46 | 11.94 | 3 | 40184 | 136535 | 79567666 |
| Lactic acidosis | 53.51 | 11.94 | 113 | 40074 | 70246 | 79633955 |
| Electrocardiogram QT prolonged | 51.97 | 11.94 | 130 | 40057 | 90256 | 79613945 |
| Change of bowel habit | 48.65 | 11.94 | 25 | 40162 | 2732 | 79701469 |
| Syncope | 48.53 | 11.94 | 199 | 39988 | 179250 | 79524951 |
| Febrile neutropenia | 45.83 | 11.94 | 30 | 40157 | 230969 | 79473232 |
| Blood sodium decreased | 45.44 | 11.94 | 69 | 40118 | 33186 | 79671015 |
| Treatment failure | 44.80 | 11.94 | 15 | 40172 | 170471 | 79533730 |
| Dizziness | 43.30 | 11.94 | 430 | 39757 | 526011 | 79178190 |
| Infusion related reaction | 42.90 | 11.94 | 32 | 40155 | 230205 | 79473996 |
| Oedema peripheral | 41.72 | 11.94 | 243 | 39944 | 252045 | 79452156 |
| Sensitisation | 41.66 | 11.94 | 24 | 40163 | 3287 | 79700914 |
| Hypotension | 41.35 | 11.94 | 370 | 39817 | 439947 | 79264254 |
| Myalgia | 41.17 | 11.94 | 194 | 39993 | 185447 | 79518754 |
| Pericarditis | 40.97 | 11.94 | 3 | 40184 | 104233 | 79599968 |
| Infection | 40.81 | 11.94 | 37 | 40150 | 241675 | 79462526 |
| Left ventricular hypertrophy | 40.15 | 11.94 | 38 | 40149 | 11153 | 79693048 |
| Presyncope | 39.77 | 11.94 | 73 | 40114 | 40981 | 79663220 |
| Hyperkalaemia | 39.31 | 11.94 | 137 | 40050 | 114261 | 79589940 |
| Needle issue | 38.76 | 11.94 | 40 | 40147 | 13028 | 79691173 |
| Renin increased | 38.56 | 11.94 | 11 | 40176 | 233 | 79703968 |
| Central nervous system lupus | 38.44 | 11.94 | 13 | 40174 | 490 | 79703711 |
| Toxicity to various agents | 38.01 | 11.94 | 99 | 40088 | 421441 | 79282760 |
| Product packaging confusion | 37.99 | 11.94 | 11 | 40176 | 246 | 79703955 |
| Vessel puncture site haemorrhage | 35.88 | 11.94 | 10 | 40177 | 194 | 79704007 |
| Angioedema | 35.26 | 11.94 | 101 | 40086 | 75934 | 79628267 |
| Dyslipidaemia | 35.21 | 11.94 | 36 | 40151 | 11597 | 79692604 |
| Rhabdomyolysis | 35.00 | 11.94 | 123 | 40064 | 103008 | 79601193 |
| Product dose omission issue | 34.98 | 11.94 | 44 | 40143 | 247493 | 79456708 |
| Metabolic acidosis | 34.81 | 11.94 | 106 | 40081 | 82423 | 79621778 |
| Hypoosmolar state | 34.73 | 11.94 | 11 | 40176 | 336 | 79703865 |
| Exposure during pregnancy | 34.38 | 11.94 | 5 | 40182 | 101127 | 79603074 |
| Urine odour abnormal | 34.08 | 11.94 | 27 | 40160 | 6246 | 79697955 |
| Nasal mucosal disorder | 33.75 | 11.94 | 11 | 40176 | 369 | 79703832 |
| Postictal paralysis | 33.75 | 11.94 | 11 | 40176 | 369 | 79703832 |
| Pemphigus | 33.68 | 11.94 | 5 | 40182 | 99577 | 79604624 |
| Orthostatic hypotension | 33.57 | 11.94 | 82 | 40105 | 56082 | 79648119 |
| Intestinal haemorrhage | 33.51 | 11.94 | 27 | 40160 | 6399 | 79697802 |
| Blood pressure inadequately controlled | 32.31 | 11.94 | 26 | 40161 | 6151 | 79698050 |
| Proctalgia | 32.20 | 11.94 | 32 | 40155 | 9969 | 79694232 |
| Jaundice | 32.00 | 11.94 | 78 | 40109 | 53271 | 79650930 |
| Hypertensive angiopathy | 31.98 | 11.94 | 8 | 40179 | 100 | 79704101 |
| Injection site discomfort | 31.92 | 11.94 | 24 | 40163 | 5142 | 79699059 |
| Furuncle | 31.69 | 11.94 | 28 | 40159 | 7526 | 79696675 |
| Tachyarrhythmia | 31.61 | 11.94 | 27 | 40160 | 6935 | 79697266 |
| Fall | 31.61 | 11.94 | 380 | 39807 | 487249 | 79216952 |
| Sinusitis | 30.59 | 11.94 | 32 | 40155 | 195469 | 79508732 |
| Renal artery stenosis | 30.43 | 11.94 | 20 | 40167 | 3462 | 79700739 |
| Swelling | 30.11 | 11.94 | 39 | 40148 | 216672 | 79487529 |
| Sprue-like enteropathy | 29.34 | 11.94 | 14 | 40173 | 1304 | 79702897 |
| Malaise | 28.01 | 11.94 | 373 | 39814 | 489496 | 79214705 |
| Contraindicated product administered | 27.94 | 11.94 | 23 | 40164 | 157515 | 79546686 |
| Frustration tolerance decreased | 27.92 | 11.94 | 26 | 40161 | 7476 | 79696725 |
| Urine abnormality | 27.77 | 11.94 | 27 | 40160 | 8192 | 79696009 |
| Dehydration | 27.75 | 11.94 | 217 | 39970 | 247970 | 79456231 |
| Drug dispensed to wrong patient | 27.10 | 11.94 | 11 | 40176 | 695 | 79703506 |
| Arrhythmia | 27.07 | 11.94 | 80 | 40107 | 61192 | 79643009 |
| Diabetes mellitus | 27.03 | 11.94 | 94 | 40093 | 78296 | 79625905 |
| Herbal interaction | 26.83 | 11.94 | 10 | 40177 | 502 | 79703699 |
| Arthropathy | 26.59 | 11.94 | 30 | 40157 | 177081 | 79527120 |
| Croup infectious | 26.37 | 11.94 | 11 | 40176 | 745 | 79703456 |
| Angular cheilitis | 26.29 | 11.94 | 11 | 40176 | 751 | 79703450 |
| Alopecia | 26.05 | 11.94 | 48 | 40139 | 231307 | 79472894 |
| Hypovolaemia | 26.02 | 11.94 | 38 | 40149 | 17653 | 79686548 |
| Metabolic alkalosis | 25.85 | 11.94 | 20 | 40167 | 4469 | 79699732 |
| Hypoglycaemia | 25.37 | 11.94 | 110 | 40077 | 101484 | 79602717 |
| Mucosal dryness | 25.31 | 11.94 | 18 | 40169 | 3541 | 79700660 |
| Bladder disorder | 25.30 | 11.94 | 27 | 40160 | 9138 | 79695063 |
| Electrolyte imbalance | 25.11 | 11.94 | 51 | 40136 | 30830 | 79673371 |
| Diabetic foot | 24.98 | 11.94 | 18 | 40169 | 3614 | 79700587 |
| Glycosylated haemoglobin increased | 24.96 | 11.94 | 39 | 40148 | 19221 | 79684980 |
| Cholestasis | 24.92 | 11.94 | 70 | 40117 | 52039 | 79652162 |
| Dysuria | 24.91 | 11.94 | 69 | 40118 | 50882 | 79653319 |
| Left atrial dilatation | 24.88 | 11.94 | 17 | 40170 | 3136 | 79701065 |
| Endoscopy upper gastrointestinal tract abnormal | 24.69 | 11.94 | 6 | 40181 | 66 | 79704135 |
| Polyp | 24.38 | 11.94 | 25 | 40162 | 8082 | 79696119 |
| Stomatitis | 24.13 | 11.94 | 23 | 40164 | 146734 | 79557467 |
| Diabetic metabolic decompensation | 24.04 | 11.94 | 17 | 40170 | 3315 | 79700886 |
| Pain | 23.96 | 11.94 | 233 | 39954 | 703569 | 79000632 |
| Ischaemic stroke | 23.79 | 11.94 | 52 | 40135 | 33079 | 79671122 |
| Butterfly rash | 23.24 | 11.94 | 13 | 40174 | 1683 | 79702518 |
| Glomerular filtration rate decreased | 22.78 | 11.94 | 41 | 40146 | 22661 | 79681540 |
| Drug hypersensitivity | 22.71 | 11.94 | 76 | 40111 | 298840 | 79405361 |
| Discomfort | 22.69 | 11.94 | 18 | 40169 | 125599 | 79578602 |
| Blood pressure abnormal | 22.57 | 11.94 | 35 | 40152 | 17134 | 79687067 |
| Circulatory collapse | 22.51 | 11.94 | 55 | 40132 | 37613 | 79666588 |
| Product use in unapproved indication | 22.38 | 11.94 | 59 | 40128 | 250300 | 79453901 |
| Postoperative wound infection | 22.28 | 11.94 | 30 | 40157 | 12931 | 79691270 |
| Mass | 22.12 | 11.94 | 35 | 40152 | 17437 | 79686764 |
| Hyperlactacidaemia | 22.01 | 11.94 | 20 | 40167 | 5575 | 79698626 |
| Atrioventricular block | 21.88 | 11.94 | 31 | 40156 | 14010 | 79690191 |
| Hypocalcaemia | 21.88 | 11.94 | 65 | 40122 | 49859 | 79654342 |
| Osmotic demyelination syndrome | 21.84 | 11.94 | 12 | 40175 | 1501 | 79702700 |
| Tumour invasion | 21.65 | 11.94 | 8 | 40179 | 392 | 79703809 |
| Platelet count decreased | 21.37 | 11.94 | 41 | 40146 | 194623 | 79509578 |
| Nail pitting | 21.35 | 11.94 | 8 | 40179 | 408 | 79703793 |
| Mental status changes | 21.23 | 11.94 | 4 | 40183 | 66955 | 79637246 |
| Nocturia | 21.02 | 11.94 | 30 | 40157 | 13651 | 79690550 |
| Blood creatinine increased | 21.01 | 11.94 | 142 | 40045 | 154915 | 79549286 |
| Disease progression | 20.97 | 11.94 | 38 | 40149 | 184324 | 79519877 |
| Renal failure | 20.97 | 11.94 | 173 | 40014 | 200795 | 79503406 |
| Blood urea increased | 20.88 | 11.94 | 63 | 40124 | 48727 | 79655474 |
| Impaired healing | 20.87 | 11.94 | 9 | 40178 | 87646 | 79616555 |
| Renal artery restenosis | 20.84 | 11.94 | 4 | 40183 | 12 | 79704189 |
| Migraine | 20.81 | 11.94 | 9 | 40178 | 87484 | 79616717 |
| Lip swelling | 20.59 | 11.94 | 56 | 40131 | 40855 | 79663346 |
| Helicobacter test positive | 20.39 | 11.94 | 11 | 40176 | 1327 | 79702874 |
| Fatigue | 20.37 | 11.94 | 338 | 39849 | 929389 | 78774812 |
| Therapeutic product effect decreased | 20.27 | 11.94 | 32 | 40155 | 163831 | 79540370 |
| Pneumonia | 20.24 | 11.94 | 224 | 39963 | 660022 | 79044179 |
| Rheumatoid factor positive | 20.24 | 11.94 | 3 | 40184 | 59836 | 79644365 |
| Vascular resistance systemic | 20.15 | 11.94 | 4 | 40183 | 15 | 79704186 |
| Gastrointestinal ischaemia | 19.96 | 11.94 | 8 | 40179 | 489 | 79703712 |
| Tubulointerstitial nephritis | 19.91 | 11.94 | 53 | 40134 | 38182 | 79666019 |
| Gravitational oedema | 19.66 | 11.94 | 12 | 40175 | 1827 | 79702374 |
| Pancreatic neoplasm | 19.38 | 11.94 | 11 | 40176 | 1465 | 79702736 |
| Renal impairment | 19.33 | 11.94 | 141 | 40046 | 157642 | 79546559 |
| Blood electrolytes abnormal | 19.10 | 11.94 | 12 | 40175 | 1922 | 79702279 |
| Haematocrit increased | 19.05 | 11.94 | 16 | 40171 | 4018 | 79700183 |
| Stenosis | 18.98 | 11.94 | 13 | 40174 | 2409 | 79701792 |
| Thyroid disorder | 18.93 | 11.94 | 29 | 40158 | 14050 | 79690151 |
| Chronic gastritis | 18.93 | 11.94 | 16 | 40171 | 4052 | 79700149 |
| Consciousness fluctuating | 18.91 | 11.94 | 12 | 40175 | 1957 | 79702244 |
| Eosinophilia | 18.89 | 11.94 | 58 | 40129 | 45287 | 79658914 |
| Bundle branch block left | 18.80 | 11.94 | 26 | 40161 | 11487 | 79692714 |
| Injection site erythema | 18.66 | 11.94 | 8 | 40179 | 78189 | 79626012 |
| Lupus nephritis | 18.64 | 11.94 | 14 | 40173 | 2994 | 79701207 |
| Glomerular filtration rate increased | 18.58 | 11.94 | 10 | 40177 | 1201 | 79703000 |
| Psychomotor retardation | 18.47 | 11.94 | 19 | 40168 | 6165 | 79698036 |
| Mucocutaneous haemorrhage | 18.39 | 11.94 | 6 | 40181 | 202 | 79703999 |
| Injection site reaction | 17.96 | 11.94 | 3 | 40184 | 54782 | 79649419 |
| Urinary retention | 17.89 | 11.94 | 66 | 40121 | 56564 | 79647637 |
| Hypersensitivity | 17.72 | 11.94 | 70 | 40117 | 262169 | 79442032 |
| Urinary incontinence | 17.67 | 11.94 | 53 | 40134 | 40856 | 79663345 |
| Paramnesia | 17.60 | 11.94 | 4 | 40183 | 32 | 79704169 |
| Peripheral coldness | 17.53 | 11.94 | 30 | 40157 | 15940 | 79688261 |
| Hypovolaemic shock | 17.52 | 11.94 | 26 | 40161 | 12250 | 79691951 |
| Blood glucose decreased | 17.51 | 11.94 | 40 | 40147 | 26194 | 79678007 |
| Hypouricaemia | 17.51 | 11.94 | 7 | 40180 | 425 | 79703776 |
| Ventricular flutter | 17.43 | 11.94 | 5 | 40182 | 108 | 79704093 |
| Rash maculo-papular | 17.42 | 11.94 | 65 | 40122 | 56013 | 79648188 |
| Swollen tongue | 17.32 | 11.94 | 54 | 40133 | 42516 | 79661685 |
| Dyspnoea exertional | 17.14 | 11.94 | 88 | 40099 | 86985 | 79617216 |
| Hepatic enzyme increased | 17.11 | 11.94 | 42 | 40145 | 182568 | 79521633 |
| Wound | 17.08 | 11.94 | 20 | 40167 | 116159 | 79588042 |
| Duodenal ulcer perforation | 17.08 | 11.94 | 6 | 40181 | 66205 | 79637996 |
| Duodenal ulcer | 16.99 | 11.94 | 30 | 40157 | 16339 | 79687862 |
| Arterial stenosis | 16.99 | 11.94 | 10 | 40177 | 1426 | 79702775 |
| Therapy non-responder | 16.96 | 11.94 | 13 | 40174 | 92292 | 79611909 |
| Haemoglobin increased | 16.81 | 11.94 | 18 | 40169 | 6114 | 79698087 |
| Peripheral artery haematoma | 16.70 | 11.94 | 5 | 40182 | 126 | 79704075 |
| Disorientation | 16.46 | 11.94 | 69 | 40118 | 62707 | 79641494 |
| Gingival hypoplasia | 16.17 | 11.94 | 3 | 40184 | 7 | 79704194 |
| Folliculitis | 16.15 | 11.94 | 4 | 40183 | 55376 | 79648825 |
| Renal artery arteriosclerosis | 16.06 | 11.94 | 4 | 40183 | 49 | 79704152 |
| Nephropathy | 15.92 | 11.94 | 22 | 40165 | 9716 | 79694485 |
| Pyrexia | 15.75 | 11.94 | 244 | 39943 | 678465 | 79025736 |
| Systemic lupus erythematosus | 15.62 | 11.94 | 23 | 40164 | 121126 | 79583075 |
| Urine albumin/creatinine ratio increased | 15.61 | 11.94 | 7 | 40180 | 566 | 79703635 |
| Product use issue | 15.49 | 11.94 | 54 | 40133 | 209768 | 79494433 |
| Poor dental condition | 15.48 | 11.94 | 7 | 40180 | 577 | 79703624 |
| Retinal detachment | 15.28 | 11.94 | 21 | 40166 | 9226 | 79694975 |
| Oedema genital | 15.23 | 11.94 | 7 | 40180 | 599 | 79703602 |
| Convulsive threshold lowered | 15.03 | 11.94 | 8 | 40179 | 939 | 79703262 |
| Nail injury | 14.99 | 11.94 | 7 | 40180 | 621 | 79703580 |
| Glossodynia | 14.97 | 11.94 | 18 | 40169 | 103319 | 79600882 |
| Lung neoplasm malignant | 14.95 | 11.94 | 39 | 40148 | 27753 | 79676448 |
| Anaemia megaloblastic | 14.92 | 11.94 | 7 | 40180 | 628 | 79703573 |
| Bundle branch block right | 14.88 | 11.94 | 23 | 40164 | 11228 | 79692973 |
| Blood glucose increased | 14.80 | 11.94 | 104 | 40083 | 114871 | 79589330 |
| Inappropriate schedule of product administration | 14.79 | 11.94 | 28 | 40159 | 133600 | 79570601 |
| Oliguria | 14.55 | 11.94 | 28 | 40159 | 16281 | 79687920 |
| Abdominal discomfort | 14.47 | 11.94 | 71 | 40116 | 250656 | 79453545 |
| Spinal pain | 14.44 | 11.94 | 27 | 40160 | 15365 | 79688836 |
| Transplant dysfunction | 14.42 | 11.94 | 18 | 40169 | 7203 | 79696998 |
| Stevens-Johnson syndrome | 14.40 | 11.94 | 48 | 40139 | 39118 | 79665083 |
| Lower respiratory tract infection | 14.37 | 11.94 | 27 | 40160 | 129193 | 79575008 |
| Multiple sclerosis relapse | 14.29 | 11.94 | 3 | 40184 | 46530 | 79657671 |
| Glycosylated haemoglobin decreased | 14.25 | 11.94 | 7 | 40180 | 695 | 79703506 |
| Ventricular extrasystoles | 14.23 | 11.94 | 31 | 40156 | 19673 | 79684528 |
| Pain in jaw | 14.12 | 11.94 | 3 | 40184 | 46148 | 79658053 |
| Wrong technique in product usage process | 14.09 | 11.94 | 10 | 40177 | 73865 | 79630336 |
| Polydipsia | 14.05 | 11.94 | 17 | 40170 | 6588 | 79697613 |
| Diabetes mellitus inadequate control | 14.04 | 11.94 | 35 | 40152 | 24229 | 79679972 |
| Swelling face | 14.04 | 11.94 | 72 | 40115 | 71140 | 79633061 |
| Drug intolerance | 14.00 | 11.94 | 77 | 40110 | 264042 | 79440159 |
| Platelet dysfunction | 13.98 | 11.94 | 6 | 40181 | 436 | 79703765 |
| Varicose vein | 13.97 | 11.94 | 14 | 40173 | 4405 | 79699796 |
| Proteinuria | 13.94 | 11.94 | 42 | 40145 | 32460 | 79671741 |
| Hypoparathyroidism | 13.92 | 11.94 | 8 | 40179 | 1090 | 79703111 |
| Protrusion tongue | 13.92 | 11.94 | 6 | 40181 | 441 | 79703760 |
| Exostosis | 13.90 | 11.94 | 28 | 40159 | 16830 | 79687371 |
| Gingival hypertrophy | 13.89 | 11.94 | 12 | 40175 | 3130 | 79701071 |
| External ear pain | 13.81 | 11.94 | 3 | 40184 | 19 | 79704182 |
| Musculoskeletal stiffness | 13.62 | 11.94 | 44 | 40143 | 174964 | 79529237 |
| Fear of eating | 13.59 | 11.94 | 6 | 40181 | 467 | 79703734 |
| Euglycaemic diabetic ketoacidosis | 13.57 | 11.94 | 17 | 40170 | 6827 | 79697374 |
| Hepatitis D | 13.47 | 11.94 | 4 | 40183 | 98 | 79704103 |
| Plasma cell myeloma | 13.44 | 11.94 | 5 | 40182 | 53254 | 79650947 |
| Hyperlipidaemia | 13.41 | 11.94 | 36 | 40151 | 26057 | 79678144 |
| Blood pressure systolic increased | 13.39 | 11.94 | 68 | 40119 | 66918 | 79637283 |
| Pemphigoid | 13.30 | 11.94 | 26 | 40161 | 15289 | 79688912 |
| Ejection fraction decreased | 13.28 | 11.94 | 43 | 40144 | 34534 | 79669667 |
| Muscle injury | 13.23 | 11.94 | 4 | 40183 | 48557 | 79655644 |
| Loss of consciousness | 13.17 | 11.94 | 136 | 40051 | 167807 | 79536394 |
| Hypocalciuria | 13.09 | 11.94 | 3 | 40184 | 25 | 79704176 |
| Hospitalisation | 13.04 | 11.94 | 17 | 40170 | 94219 | 79609982 |
| Product monitoring error | 12.91 | 11.94 | 19 | 40168 | 8887 | 79695314 |
| Heart rate irregular | 12.87 | 11.94 | 41 | 40146 | 32638 | 79671563 |
| Glucose tolerance impaired | 12.82 | 11.94 | 18 | 40169 | 8066 | 79696135 |
| Spur cell anaemia | 12.80 | 11.94 | 4 | 40183 | 117 | 79704084 |
| Unevaluable event | 12.77 | 11.94 | 6 | 40181 | 55579 | 79648622 |
| Vulvovaginal inflammation | 12.77 | 11.94 | 6 | 40181 | 540 | 79703661 |
| Hyperuricaemia | 12.73 | 11.94 | 22 | 40165 | 11777 | 79692424 |
| Pancytopenia | 12.67 | 11.94 | 42 | 40145 | 165703 | 79538498 |
| Ephelides | 12.64 | 11.94 | 4 | 40183 | 122 | 79704079 |
| Rheumatoid arthritis | 12.63 | 11.94 | 58 | 40129 | 208412 | 79495789 |
| Asthenia | 12.53 | 11.94 | 342 | 39845 | 511347 | 79192854 |
| Brain stem haematoma | 12.48 | 11.94 | 4 | 40183 | 127 | 79704074 |
| Polyuria | 12.45 | 11.94 | 25 | 40162 | 14989 | 79689212 |
| Angle closure glaucoma | 12.42 | 11.94 | 11 | 40176 | 2965 | 79701236 |
| Extranodal marginal zone B-cell lymphoma (MALT type) | 12.27 | 11.94 | 6 | 40181 | 590 | 79703611 |
| Fungal infection | 12.20 | 11.94 | 3 | 40184 | 41745 | 79662456 |
| Osteoporosis | 12.19 | 11.94 | 6 | 40181 | 54106 | 79650095 |
| Sleep disorder due to a general medical condition | 12.11 | 11.94 | 24 | 40163 | 14253 | 79689948 |
| Hypertensive crisis | 12.06 | 11.94 | 30 | 40157 | 20740 | 79683461 |
| Acetonaemia | 12.01 | 11.94 | 5 | 40182 | 337 | 79703864 |
| Pyelonephritis acute | 12.00 | 11.94 | 15 | 40172 | 6008 | 79698193 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C03BA11 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, EXCL. THIAZIDES Sulfonamides, plain |
| ATC | C09BX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
| ATC | C10BX13 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
| FDA PE | N0000175359 | Increased Diuresis |
| FDA EPC | N0000175420 | Thiazide-like Diuretic |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004232 | Diuretics |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D045283 | Natriuretic Agents |
| MeSH PA | D049993 | Sodium Chloride Symporter Inhibitors |
| CHEBI has role | CHEBI:35498 | diuretics |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Edema | indication | 267038008 | |
| Anuria | contraindication | 2472002 | DOID:2983 |
| Dehydration | contraindication | 34095006 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Hypokalemia | contraindication | 43339004 | |
| Sympathectomy | contraindication | 57071006 | |
| Acute nephropathy | contraindication | 58574008 | |
| Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Oliguria | contraindication | 83128009 | |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.53 | acidic |
| pKa2 | 9.54 | acidic |
| pKa3 | 5.52 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Solute carrier family 12 member 3 | Transporter | INHIBITOR | A2 | 7.54 | WOMBAT-PK | CHEMBL | |||
| Carbonic anhydrase 1 | Enzyme | Kd | 5 | CHEMBL | |||||
| Carbonic anhydrase 4 | Enzyme | Ki | 6.67 | CHEMBL | |||||
| Carbonic anhydrase 9 | Enzyme | Ki | 7.44 | CHEMBL | |||||
| Carbonic anhydrase 12 | Enzyme | Ki | 8 | CHEMBL | |||||
| Potassium voltage-gated channel subfamily KQT member 1 | Ion channel | WOMBAT-PK | |||||||
| Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 6.05 | CHEMBL | |||||
| Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 6.56 | CHEMBL | |||||
| Carbonic anhydrase 7 | Enzyme | Ki | 9.64 | CHEMBL | |||||
| Carbonic anhydrase 6 | Enzyme | Kd | 6.60 | CHEMBL | |||||
| Carbonic anhydrase 14 | Enzyme | Ki | 5.31 | CHEMBL | |||||
| Carbonic anhydrase 2 | Enzyme | Kd | 6.70 | CHEMBL | |||||
| Carbonic anhydrase 13 | Enzyme | Kd | 7 | CHEMBL | |||||
| Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.54 | DRUG MATRIX | |||||
| Carbonic anhydrase 13 | Enzyme | Ki | 7.89 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018746 | VUID |
| N0000147050 | NUI |
| D00345 | KEGG_DRUG |
| 180004-24-4 | SECONDARY_CAS_RN |
| 4018746 | VANDF |
| C0021186 | UMLSCUI |
| CHEBI:5893 | CHEBI |
| BL1 | PDB_CHEM_ID |
| CHEMBL406 | ChEMBL_ID |
| DB00808 | DRUGBANK_ID |
| D007190 | MESH_DESCRIPTOR_UI |
| 3702 | PUBCHEM_CID |
| 7203 | IUPHAR_LIGAND_ID |
| 3333 | INN_ID |
| F089I0511L | UNII |
| 5764 | RXNORM |
| 2360 | MMSL |
| 4873 | MMSL |
| d00260 | MMSL |
| 002313 | NDDF |
| 387419003 | SNOMEDCT_US |
| 725661001 | SNOMEDCT_US |
| 74213004 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2571 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2571 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2571 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2597 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2597 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2597 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0069 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0080 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
| Indapamide | Human Prescription Drug Label | 1 | 16571-875 | TABLET | 1.25 mg | ORAL | ANDA | 18 sections |
| Indapamide | Human Prescription Drug Label | 1 | 16571-876 | TABLET | 2.50 mg | ORAL | ANDA | 18 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-576 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-348 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-349 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-024 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-025 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62559-510 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62559-511 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1953 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1953 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1954 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1954 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 19 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68151-1294 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68788-7247 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68788-7247 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68788-7247 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 20 sections |
| Indapamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71335-1541 | TABLET, FILM COATED | 1.25 mg | ORAL | ANDA | 19 sections |