indapamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, sulfamoylbenzoic acid derivatives	1433	26807-65-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: metindamide indapamide hemihydrate indapamide flupamid indaflex indamide indamol veroxil (+/-)-Indapamide	A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS. Molecular weight: 365.83 Formula: C16H16ClN3O3S CLOGP: 2.96 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 92.50 ALOGS: -4.03 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

metindamide
indapamide hemihydrate
indapamide
flupamid
indaflex
indamide
indamol
veroxil
(+/-)-Indapamide

A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.

Molecular weight: 365.83
Formula: C16H16ClN3O3S
CLOGP: 2.96
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 92.50
ALOGS: -4.03
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
2.50	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.59 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	7 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.20 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	90 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
July 6, 1983	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	1324.96	13.59	705	22793	101434	56167135
Hypokalaemia	548.18	13.59	391	23107	94046	56174523
Acute kidney injury	235.68	13.59	386	23112	240377	56028192
Inappropriate antidiuretic hormone secretion	155.36	13.59	87	23411	13669	56254900
Confusional state	114.72	13.59	262	23236	207893	56060676
Hypochloraemia	113.74	13.59	38	23460	1674	56266895
Drug interaction	103.60	13.59	253	23245	209502	56059067
Hypomagnesaemia	97.54	13.59	82	23416	24933	56243636
Burning mouth syndrome	87.88	13.59	23	23475	425	56268144
Hyponatraemic seizure	83.73	13.59	22	23476	413	56268156
Conjoined twins	72.79	13.59	18	23480	262	56268307
Torsade de pointes	70.75	13.59	51	23447	12389	56256180
Labile hypertension	63.13	13.59	18	23480	463	56268106
Blood pressure increased	61.10	13.59	165	23333	145011	56123558
Rectal polyp	59.14	13.59	21	23477	1112	56267457
Maternal exposure during pregnancy	57.76	13.59	6	23492	189547	56079022
Drug ineffective	56.08	13.59	197	23301	918792	55349777
Electrocardiogram QT prolonged	55.14	13.59	89	23409	54499	56214070
Congenital bladder anomaly	53.79	13.59	13	23485	171	56268398
Intestinal malrotation	53.44	13.59	15	23483	364	56268205
Urachal abnormality	53.24	13.59	13	23485	179	56268390
Persistent cloaca	52.39	13.59	13	23485	192	56268377
Death	48.21	13.59	43	23455	341383	55927186
Rheumatoid arthritis	46.31	13.59	55	23443	382549	55886020
Product packaging confusion	45.22	13.59	11	23487	149	56268420
Off label use	45	13.59	104	23394	556076	55712493
Change of bowel habit	43.53	13.59	20	23478	2069	56266500
Sprue-like enteropathy	43.29	13.59	14	23484	556	56268013
Vessel puncture site haemorrhage	43.10	13.59	10	23488	109	56268460
Atrial fibrillation	43.04	13.59	121	23377	108776	56159793
Blood sodium decreased	41.66	13.59	49	23449	22285	56246284
Intestinal haemorrhage	41.59	13.59	23	23475	3523	56265046
Sensitisation	41.14	13.59	20	23478	2348	56266221
Infection	39.59	13.59	17	23481	200189	56068380
Proctalgia	39.37	13.59	26	23472	5483	56263086
Left ventricular hypertrophy	39.25	13.59	25	23473	4959	56263610
Dehydration	38.92	13.59	150	23348	158675	56109894
Metabolic acidosis	35.57	13.59	62	23436	40392	56228177
Exposure during pregnancy	35.30	13.59	7	23491	136335	56132234
Renin increased	35.14	13.59	9	23489	152	56268417
Infusion related reaction	35.00	13.59	22	23476	208909	56059660
Fall	34.97	13.59	262	23236	357248	55911321
Hypertensive angiopathy	34.67	13.59	8	23490	85	56268484
Alopecia	34.62	13.59	43	23455	293415	55975154
Nasal mucosal disorder	33.91	13.59	11	23487	441	56268128
Arthropathy	33.67	13.59	21	23477	200254	56068315
Croup infectious	33.45	13.59	11	23487	461	56268108
Systemic lupus erythematosus	32.97	13.59	17	23481	180061	56088508
Needle issue	32.73	13.59	28	23470	8710	56259859
Furuncle	32.54	13.59	24	23474	6035	56262534
Hyperlactacidaemia	30.94	13.59	17	23481	2571	56265998
Eosinophilia	30.92	13.59	40	23458	20037	56248532
Central nervous system lupus	30.78	13.59	10	23488	403	56268166
Injection site discomfort	30.62	13.59	20	23478	4140	56264429
Glossodynia	30.05	13.59	13	23485	152445	56116124
Bradycardia	29.65	13.59	78	23420	67426	56201143
Dysuria	29.53	13.59	49	23449	30680	56237889
Contraindicated product administered	29.34	13.59	21	23477	186265	56082304
Orthostatic hypotension	29.34	13.59	51	23447	33148	56235421
Duodenal ulcer	29.01	13.59	24	23474	7131	56261438
Urine odour abnormal	28.73	13.59	22	23476	5852	56262717
Product dose omission issue	28.60	13.59	26	23472	204727	56063842
Treatment failure	28.45	13.59	18	23480	170374	56098195
Swelling	28.40	13.59	35	23463	239736	56028833
Angioedema	28.29	13.59	57	23441	41396	56227173
Lactic acidosis	28.29	13.59	52	23446	35294	56233275
Hypotension	27.59	13.59	189	23309	250319	56018250
Hepatic enzyme increased	27.41	13.59	19	23479	171365	56097204
Postoperative wound infection	27.31	13.59	26	23472	9287	56259282
Dyslipidaemia	27.21	13.59	22	23476	6331	56262238
Gravitational oedema	26.86	13.59	12	23486	1163	56267406
Diabetic metabolic decompensation	26.67	13.59	13	23485	1535	56267034
Urine abnormality	26.18	13.59	22	23476	6677	56261892
Hypouricaemia	25.90	13.59	7	23491	147	56268422
Blood electrolytes abnormal	25.56	13.59	11	23487	975	56267594
Frustration tolerance decreased	25.11	13.59	21	23477	6332	56262237
Discomfort	25.04	13.59	14	23484	141747	56126822
Bladder disorder	24.67	13.59	23	23475	8001	56260568
Dizziness	24.43	13.59	252	23246	375888	55892681
Polyp	24.23	13.59	20	23478	5922	56262647
Convulsive threshold lowered	24.19	13.59	8	23490	341	56268228
Mucocutaneous haemorrhage	24.03	13.59	6	23492	91	56268478
Circulatory collapse	23.89	13.59	36	23462	20767	56247802
Abdominal discomfort	23.87	13.59	50	23448	277224	55991345
Mass	23.66	13.59	28	23470	12811	56255758
Peripheral coldness	23.66	13.59	26	23472	10985	56257584
Presyncope	23.52	13.59	40	23458	25542	56243027
Platelet dysfunction	23.39	13.59	6	23492	102	56268467
Sinusitis	23.23	13.59	29	23469	197552	56071017
Urinary incontinence	23.02	13.59	43	23455	29542	56239027
Renal impairment	22.92	13.59	80	23418	80633	56187936
Paramnesia	22.74	13.59	4	23494	8	56268561
Wound	22.71	13.59	15	23483	138789	56129780
Blood pressure inadequately controlled	22.25	13.59	17	23481	4507	56264062
Ischaemic stroke	22.04	13.59	31	23467	16811	56251758
Vomiting	21.94	13.59	310	23188	497918	55770651
Renal artery stenosis	21.86	13.59	12	23486	1811	56266758
Oliguria	21.83	13.59	22	23476	8418	56260151
Urine albumin/creatinine ratio increased	21.79	13.59	7	23491	272	56268297
Glomerular filtration rate decreased	21.27	13.59	26	23472	12303	56256266
Rhabdomyolysis	21.02	13.59	50	23448	40608	56227961
Syncope	20.86	13.59	95	23403	108104	56160465
Impaired work ability	20.84	13.59	28	23470	14544	56254025
Psychomotor retardation	20.76	13.59	15	23483	3654	56264915
Glycosylated haemoglobin increased	20.00	13.59	24	23474	11141	56257428
Hypovolaemic shock	19.68	13.59	17	23481	5356	56263213
Fatigue	19.58	13.59	223	23275	788329	55480240
Malaise	19.56	13.59	237	23261	367623	55900946
Retinal detachment	19.50	13.59	17	23481	5424	56263145
Impaired healing	19.48	13.59	6	23492	86835	56181734
Iron deficiency	19.37	13.59	18	23480	6238	56262331
Labelled drug-drug interaction medication error	19.29	13.59	24	23474	11562	56257007
Spinal pain	18.80	13.59	24	23474	11860	56256709
Blood pressure systolic increased	18.76	13.59	48	23450	40788	56227781
Rash	18.62	13.59	125	23373	492922	55775647
Pyelonephritis acute	18.56	13.59	15	23483	4314	56264255
Drug abuse	18.51	13.59	3	23495	67607	56200962
Myalgia	18.50	13.59	106	23392	131919	56136650
Butterfly rash	18.30	13.59	10	23488	1496	56267073
Hypoglycaemia	18.22	13.59	58	23440	55757	56212812
Vulvovaginal inflammation	18.11	13.59	8	23490	755	56267814
Heart rate decreased	18.04	13.59	47	23451	40380	56228189
Jaundice	17.99	13.59	37	23461	27257	56241312
Leukocyturia	17.97	13.59	9	23489	1126	56267443
Failure to suspend medication	17.83	13.59	4	23494	37	56268532
Hypotonia	17.80	13.59	20	23478	8657	56259912
Migraine	17.74	13.59	7	23491	86790	56181779
Stevens-Johnson syndrome	17.70	13.59	33	23465	22630	56245939
Anuria	17.44	13.59	23	23475	11737	56256832
Thyroid disorder	17.27	13.59	25	23473	13913	56254656
Hepatitis D	17.21	13.59	4	23494	44	56268525
Blood urea increased	17.11	13.59	34	23464	24439	56244130
Metabolic alkalosis	16.92	13.59	12	23486	2839	56265730
Serratia infection	16.89	13.59	8	23490	887	56267682
Protrusion tongue	16.85	13.59	6	23492	320	56268249
Blood glucose increased	16.79	13.59	69	23429	75082	56193487
Inclusion body myositis	16.74	13.59	3	23495	7	56268562
Fear of eating	16.39	13.59	6	23492	347	56268222
Intracranial haematoma	16.26	13.59	6	23492	355	56268214
Blood creatine phosphokinase increased	16.24	13.59	36	23462	27916	56240653
Haematoma	16.14	13.59	39	23459	31980	56236589
Drug hypersensitivity	15.97	13.59	60	23438	275145	55993424
Arrhythmia	15.87	13.59	41	23457	35042	56233527
Urine output decreased	15.86	13.59	21	23477	10756	56257813
Hypocalciuria	15.73	13.59	3	23495	11	56268558
Lung neoplasm malignant	15.73	13.59	27	23471	17369	56251200
Poor dental condition	15.56	13.59	6	23492	401	56268168
Weight increased	15.43	13.59	47	23451	229656	56038913
Hospitalisation	15.41	13.59	6	23492	74994	56193575
Normocytic anaemia	15.08	13.59	9	23489	1590	56266979
Therapeutic product effect decreased	15.04	13.59	30	23468	169422	56099147
Lupus nephritis	15.02	13.59	11	23487	2736	56265833
Blood pressure abnormal	14.79	13.59	23	23475	13637	56254932
Pain	14.73	13.59	192	23306	662992	55605577
Injection site erythema	14.63	13.59	7	23491	77441	56191128
Exostosis	14.58	13.59	24	23474	14919	56253650
Lower respiratory tract infection	14.39	13.59	16	23482	114778	56153791
Red blood cell sedimentation rate abnormal	14.35	13.59	27	23471	18646	56249923
Neglect of personal appearance	14.25	13.59	4	23494	97	56268472
Lymphocytic infiltration	14.14	13.59	7	23491	855	56267714
Ventricular fibrillation	14.09	13.59	20	23478	10932	56257637
Tubulointerstitial nephritis	13.94	13.59	25	23473	16640	56251929
Nail injury	13.93	13.59	6	23492	533	56268036
Oedema peripheral	13.70	13.59	120	23378	171134	56097435

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	281.41	14.25	259	15786	73540	31607759
Hypokalaemia	223.67	14.25	198	15847	53376	31627923
Acute kidney injury	115.27	14.25	356	15689	279358	31401941
Hypomagnesaemia	84.51	14.25	73	15972	18985	31662314
Death	75.10	14.25	45	16000	360524	31320775
Drug interaction	71.76	14.25	250	15795	208293	31473006
Hypoosmolar state	44.42	14.25	10	16035	76	31681223
Bradycardia	41.00	14.25	101	15944	69226	31612073
Mucosal dryness	37.28	14.25	16	16029	1159	31680140
Hyperkalaemia	37.25	14.25	93	15952	64258	31617041
Syncope	37.22	14.25	111	15934	85071	31596228
Completed suicide	35.17	14.25	3	16042	91511	31589788
Lactic acidosis	34.91	14.25	60	15985	31877	31649422
Left atrial dilatation	34.07	14.25	17	16028	1738	31679561
Postictal paralysis	33.87	14.25	10	16035	239	31681060
Drug abuse	33.39	14.25	3	16042	87755	31593544
Drug dispensed to wrong patient	31.21	14.25	11	16034	468	31680831
Atrial fibrillation	31.17	14.25	127	15918	113656	31567643
Drug ineffective	30.42	14.25	101	15944	395472	31285827
Herbal interaction	29.99	14.25	10	16035	359	31680940
Haematocrit increased	29.98	14.25	16	16029	1881	31679418
Hypotension	29.09	14.25	190	15855	204428	31476871
Obesity	27.58	14.25	31	16014	11069	31670230
Oedema peripheral	27.28	14.25	119	15926	109720	31571579
Consciousness fluctuating	25.29	14.25	12	16033	1099	31680200
Off label use	25.10	14.25	91	15954	347183	31334116
Haemoglobin increased	24.95	14.25	17	16028	3109	31678190
Renal artery arteriosclerosis	24.53	14.25	5	16040	22	31681277
Tumour invasion	24	14.25	8	16037	287	31681012
Gastrointestinal ischaemia	23.64	14.25	7	16038	169	31681130
Dizziness	23.63	14.25	177	15868	198970	31482329
Cholestasis	23.42	14.25	44	16001	25031	31656268
Polyuria	23.32	14.25	24	16021	7759	31673540
Myalgia	22.55	14.25	88	15957	77170	31604129
Electrolyte imbalance	22.14	14.25	29	16016	12119	31669180
Tachyarrhythmia	22.10	14.25	16	16029	3223	31678076
Inappropriate antidiuretic hormone secretion	22.04	14.25	28	16017	11359	31669940
Pancreatic neoplasm	21.64	14.25	10	16035	863	31680436
Nail pitting	20.98	14.25	7	16038	252	31681047
Renal artery restenosis	20.82	14.25	4	16041	12	31681287
Febrile neutropenia	20.36	14.25	19	16026	121830	31559469
Dyspnoea exertional	20.26	14.25	54	15991	38783	31642516
Lip swelling	20.06	14.25	29	16016	13294	31668005
Angioedema	19.87	14.25	49	15996	33569	31647730
Bundle branch block right	19.86	14.25	21	16024	7003	31674296
Onychophagia	19.86	14.25	5	16040	64	31681235
Presyncope	19.52	14.25	33	16012	17295	31664004
Angular cheilitis	19.15	14.25	6	16039	176	31681123
Hypoparathyroidism	18.99	14.25	8	16037	553	31680746
Ventricular flutter	18.94	14.25	5	16040	78	31681221
Renal pain	18.88	14.25	14	16031	2925	31678374
Glycosylated haemoglobin decreased	18.37	14.25	7	16038	372	31680927
Oedema genital	18.16	14.25	7	16038	384	31680915
Hepatic ischaemia	18.14	14.25	7	16038	385	31680914
Tubulointerstitial nephritis	17.95	14.25	33	16012	18463	31662836
Neutrophilia	17.59	14.25	15	16030	3828	31677471
Skin disorder	17.43	14.25	26	16019	12255	31669044
Arrhythmia	17.26	14.25	46	15999	33031	31648268
Hypovolaemia	16.86	14.25	21	16024	8351	31672948
Electrocardiogram T wave abnormal	16.84	14.25	10	16035	1443	31679856
Wheezing	16.75	14.25	48	15997	35938	31645361
Arterial stenosis	16.30	14.25	9	16036	1132	31680167
Gingival hypoplasia	16.16	14.25	3	16042	7	31681292
Thrombocytosis	15.96	14.25	14	16031	3709	31677590
Atrioventricular block	15.78	14.25	19	16026	7296	31674003
External ear pain	15.61	14.25	3	16042	9	31681290
Metastases to peritoneum	15.61	14.25	10	16035	1650	31679649
Pneumonia	15.43	14.25	103	15942	335209	31346090
Nocturia	15.23	14.25	21	16024	9214	31672085
Choroidal effusion	15.17	14.25	5	16040	173	31681126
Hypocalcaemia	15.13	14.25	34	16011	21944	31659355
Plasma cell myeloma	14.91	14.25	5	16040	56526	31624773
Erectile dysfunction	14.65	14.25	31	16014	19204	31662095
Polydipsia	14.56	14.25	13	16032	3527	31677772
Face oedema	14.39	14.25	22	16023	10594	31670705
Ephelides	14.27	14.25	4	16041	79	31681220

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	1376.57	12.12	917	35938	159170	70732419
Hypokalaemia	695.06	12.12	562	36293	130626	70760963
Acute kidney injury	307.64	12.12	726	36129	473898	70417691
Hypomagnesaemia	180.93	12.12	158	36697	40606	70850983
Drug interaction	158.39	12.12	496	36359	380945	70510644
Inappropriate antidiuretic hormone secretion	136.31	12.12	106	36749	23170	70868419
Confusional state	113.45	12.12	365	36490	284033	70607556
Hypochloraemia	111.45	12.12	42	36813	2109	70889480
Death	99.71	12.12	72	36783	509989	70381600
Completed suicide	97.39	12.12	5	36850	227130	70664459
Atrial fibrillation	80.23	12.12	244	36611	184104	70707485
Burning mouth syndrome	79.89	12.12	23	36832	488	70891101
Hyponatraemic seizure	79.40	12.12	23	36832	499	70891090
Off label use	74.03	12.12	174	36681	742886	70148703
Torsade de pointes	70.05	12.12	65	36790	18051	70873538
Drug ineffective	62.02	12.12	265	36590	939487	69952102
Bradycardia	58.99	12.12	170	36685	124445	70767144
Labile hypertension	57.25	12.12	18	36837	520	70891069
Lactic acidosis	56.09	12.12	112	36743	64912	70826677
Drug abuse	55.31	12.12	6	36849	147250	70744339
Blood pressure increased	52.16	12.12	215	36640	188302	70703287
Electrocardiogram QT prolonged	51.79	12.12	126	36729	83391	70808198
Syncope	50.67	12.12	195	36660	165514	70726075
Rectal polyp	49.23	12.12	21	36834	1459	70890130
Maternal exposure during pregnancy	47.99	12.12	3	36852	115342	70776247
Blood sodium decreased	46.08	12.12	68	36787	30930	70860659
Dizziness	42.88	12.12	398	36457	463743	70427846
Presyncope	41.71	12.12	72	36783	37366	70854223
Hypotension	41.58	12.12	355	36500	404026	70487563
Angioedema	40.77	12.12	100	36755	66510	70825079
Febrile neutropenia	39.61	12.12	29	36826	204289	70687300
Rheumatoid arthritis	38.98	12.12	57	36798	291748	70599841
Product packaging confusion	38.82	12.12	11	36844	220	70891369
Renin increased	38.77	12.12	11	36844	221	70891368
Myalgia	38.46	12.12	181	36674	167711	70723878
Change of bowel habit	37.68	12.12	21	36834	2618	70888971
Infusion related reaction	37.06	12.12	29	36826	197505	70694084
Hypoosmolar state	36.61	12.12	11	36844	272	70891317
Vessel puncture site haemorrhage	36.44	12.12	10	36845	177	70891412
Left ventricular hypertrophy	36.37	12.12	35	36820	10167	70881422
Sensitisation	36.19	12.12	20	36835	2453	70889136
Treatment failure	35.83	12.12	15	36840	144127	70747462
Infection	34.67	12.12	35	36820	210750	70680839
Needle issue	34.38	12.12	35	36820	10880	70880709
Nasal mucosal disorder	34.04	12.12	11	36844	348	70891241
Metabolic acidosis	33.79	12.12	100	36755	74246	70817343
Toxicity to various agents	33.68	12.12	95	36760	382077	70509512
Pericarditis	32.98	12.12	3	36852	84702	70806887
Pemphigus	32.17	12.12	3	36852	83033	70808556
Hypertensive angiopathy	31.74	12.12	8	36847	100	70891489
Oedema peripheral	31.69	12.12	215	36640	227876	70663713
Sprue-like enteropathy	31.23	12.12	14	36841	1096	70890493
Orthostatic hypotension	30.94	12.12	77	36778	51666	70839923
Sinusitis	30.29	12.12	26	36829	169169	70722420
Postictal paralysis	30.06	12.12	10	36845	347	70891242
Hyperkalaemia	29.79	12.12	122	36733	106469	70785120
Blood pressure inadequately controlled	29.59	12.12	24	36831	5568	70886021
Exposure during pregnancy	29.55	12.12	5	36850	87712	70803877
Drug dispensed to wrong patient	28.91	12.12	11	36844	567	70891022
Central nervous system lupus	28.90	12.12	10	36845	392	70891197
Proctalgia	28.46	12.12	28	36827	8355	70883234
Fall	28.45	12.12	354	36501	443742	70447847
Dehydration	28.40	12.12	208	36647	225934	70665655
Croup infectious	28.13	12.12	11	36844	611	70890978
Product dose omission issue	27.56	12.12	44	36811	217424	70674165
Herbal interaction	27.37	12.12	10	36845	460	70891129
Cholestasis	27.33	12.12	70	36785	47802	70843787
Arrhythmia	26.94	12.12	77	36778	56066	70835523
Metabolic alkalosis	26.85	12.12	20	36835	4096	70887493
Mucosal dryness	26.46	12.12	18	36837	3198	70888391
Dyslipidaemia	26.40	12.12	29	36826	9831	70881758
Intestinal haemorrhage	26.02	12.12	23	36832	5997	70885592
Swelling	25.98	12.12	36	36819	188503	70703086
Left atrial dilatation	25.98	12.12	17	36838	2832	70888757
Furuncle	24.93	12.12	24	36831	6974	70884615
Diabetic metabolic decompensation	24.92	12.12	17	36838	3035	70888554
Injection site discomfort	24.62	12.12	20	36835	4649	70886940
Glycosylated haemoglobin increased	24.20	12.12	37	36818	17354	70874235
Angular cheilitis	24.18	12.12	10	36845	643	70890946
Electrolyte imbalance	24.04	12.12	47	36808	26814	70864775
Hypocalcaemia	23.97	12.12	64	36791	44795	70846794
Tubulointerstitial nephritis	23.89	12.12	53	36802	33023	70858566
Renal artery stenosis	23.79	12.12	17	36838	3267	70888322
Circulatory collapse	23.58	12.12	55	36800	35419	70856170
Urine odour abnormal	23.28	12.12	21	36834	5622	70885967
Pain	23.21	12.12	212	36643	628604	70262985
Blood pressure abnormal	23.01	12.12	34	36821	15480	70876109
Plasma cell myeloma	22.91	12.12	5	36850	73196	70818393
Contraindicated product administered	22.53	12.12	22	36833	134590	70756999
Atrioventricular block	22.06	12.12	30	36825	12658	70878931
Tumour invasion	22.04	12.12	8	36847	361	70891228
Frustration tolerance decreased	21.87	12.12	22	36833	6743	70884846
Ischaemic stroke	21.83	12.12	49	36806	30771	70860818
Jaundice	21.45	12.12	66	36789	50042	70841547
Nocturia	21.43	12.12	29	36826	12175	70879414
Gastrointestinal ischaemia	21.32	12.12	8	36847	397	70891192
Dysuria	21.19	12.12	62	36793	45732	70845857
Hyperlactacidaemia	21.17	12.12	19	36836	5053	70886536
Helicobacter test positive	21.04	12.12	11	36844	1208	70890381
Eosinophilia	21.02	12.12	57	36798	40262	70851327
Urine abnormality	20.90	12.12	23	36832	7815	70883774
Injection site erythema	20.85	12.12	6	36849	72918	70818671
Renal artery restenosis	20.71	12.12	4	36851	12	70891577
Renal failure	20.45	12.12	168	36687	188902	70702687
Drug hypersensitivity	20.43	12.12	69	36786	262390	70629199
Malaise	20.42	12.12	327	36528	432605	70458984
Osmotic demyelination syndrome	20.39	12.12	11	36844	1286	70890303
Mental status changes	20.38	12.12	4	36851	63097	70828492
Arthropathy	20.32	12.12	29	36826	150028	70741561
Rhabdomyolysis	20.30	12.12	101	36754	95659	70795930
Bundle branch block left	20.26	12.12	26	36829	10373	70881216
Rash maculo-papular	20.19	12.12	65	36790	50480	70841109
Alopecia	20.04	12.12	46	36809	198444	70693145
Haematocrit increased	19.90	12.12	16	36839	3666	70887923
Gravitational oedema	19.86	12.12	12	36843	1740	70889849
Bladder disorder	19.84	12.12	23	36832	8266	70883323
Consciousness fluctuating	19.71	12.12	12	36843	1764	70889825
Hypoglycaemia	19.63	12.12	99	36756	94265	70797324
Hypovolaemic shock	19.41	12.12	26	36829	10811	70880778
Stomatitis	19.29	12.12	23	36832	128488	70763101
Platelet count decreased	19.06	12.12	40	36815	178182	70713407
Swollen tongue	18.94	12.12	52	36803	36994	70854595
Nail pitting	18.87	12.12	7	36848	336	70891253
Lip swelling	18.62	12.12	49	36806	34005	70857584
Mucocutaneous haemorrhage	18.56	12.12	6	36849	190	70891399
Postoperative wound infection	18.50	12.12	26	36829	11312	70880277
Paramnesia	18.34	12.12	4	36851	25	70891564
Fatigue	18.29	12.12	310	36545	824009	70067580
Glomerular filtration rate decreased	18.19	12.12	36	36819	20720	70870869
Hypovolaemia	18.13	12.12	31	36824	15962	70875627
Mass	18.08	12.12	31	36824	15995	70875594
Psychomotor retardation	17.72	12.12	18	36837	5580	70886009
Ventricular flutter	17.69	12.12	5	36850	99	70891490
Haemoglobin increased	17.67	12.12	18	36837	5597	70885992
Hypouricaemia	17.45	12.12	7	36848	416	70891173
Blood glucose increased	17.34	12.12	102	36753	102880	70788709
Polyp	17.34	12.12	20	36835	7150	70884439
Renal impairment	17.26	12.12	131	36724	143806	70747783
Pneumonia	17.13	12.12	213	36642	596019	70295570
Renal artery arteriosclerosis	17.06	12.12	4	36851	36	70891553
Urine albumin/creatinine ratio increased	16.98	12.12	7	36848	446	70891143
Arterial stenosis	16.98	12.12	10	36845	1383	70890206
Blood electrolytes abnormal	16.97	12.12	11	36844	1803	70889786
Disease progression	16.89	12.12	35	36820	156637	70734952
Hypertension	16.83	12.12	231	36624	295802	70595787
Discomfort	16.77	12.12	18	36837	105418	70786171
Butterfly rash	16.74	12.12	10	36845	1420	70890169
Pancreatic neoplasm	16.66	12.12	10	36845	1433	70890156
Pyrexia	16.64	12.12	219	36636	606733	70284856
Oedema genital	16.59	12.12	7	36848	473	70891116
Impaired healing	16.54	12.12	9	36846	74365	70817224
Injection site reaction	16.44	12.12	3	36852	49849	70841740
Therapeutic product effect decreased	16.24	12.12	31	36824	142987	70748602
Gingival hypoplasia	16.08	12.12	3	36852	7	70891582
Stevens-Johnson syndrome	16.03	12.12	48	36807	35859	70855730
Product use in unapproved indication	15.83	12.12	55	36800	207423	70684166
Wrong technique in product usage process	15.74	12.12	8	36847	68690	70822899
Migraine	15.69	12.12	9	36846	72229	70819360
Systemic lupus erythematosus	15.54	12.12	18	36837	101884	70789705
Bundle branch block right	15.37	12.12	23	36832	10587	70881002
Hepatic enzyme increased	15.35	12.12	37	36818	156953	70734636
Anaemia megaloblastic	15.32	12.12	7	36848	573	70891016
Ventricular extrasystoles	15.24	12.12	31	36824	18195	70873394
White blood cell count decreased	15.18	12.12	42	36813	170099	70721490
Convulsive threshold lowered	14.99	12.12	8	36847	916	70890673
Diabetes mellitus inadequate control	14.93	12.12	35	36820	22610	70868979
Glucose tolerance impaired	14.83	12.12	18	36837	6788	70884801
Thyroid disorder	14.71	12.12	25	36830	12807	70878782
Spinal pain	14.71	12.12	26	36829	13744	70877845
Retinal detachment	14.69	12.12	20	36835	8447	70883142
Glycosylated haemoglobin decreased	14.52	12.12	7	36848	647	70890942
Inclusion body myositis	14.49	12.12	3	36852	14	70891575
Platelet dysfunction	14.41	12.12	6	36849	392	70891197
Gingival hypertrophy	14.41	12.12	12	36843	2886	70888703
Hospitalisation	14.39	12.12	13	36842	82555	70809034
Pemphigoid	14.37	12.12	26	36829	13996	70877593
External ear pain	14.32	12.12	3	36852	15	70891574
Hypersensitivity	14.32	12.12	66	36789	229746	70661843
Protrusion tongue	14.31	12.12	6	36849	399	70891190
Hypoparathyroidism	14.29	12.12	8	36847	1006	70890583
Medication error	14.24	12.12	63	36792	56849	70834740
Tachyarrhythmia	14.10	12.12	17	36838	6365	70885224
Chronic gastritis	14.04	12.12	13	36842	3600	70887989
Fear of eating	13.99	12.12	6	36849	422	70891167
Hepatitis D	13.89	12.12	4	36851	85	70891504
Proteinuria	13.81	12.12	40	36815	29334	70862255
Ventricular tachycardia	13.79	12.12	46	36809	36377	70855212
Peripheral coldness	13.74	12.12	26	36829	14474	70877115
Product use issue	13.52	12.12	48	36807	179889	70711700
Blood glucose decreased	13.45	12.12	35	36820	24124	70867465
Wound	13.44	12.12	19	36836	98713	70792876
Diabetes mellitus	13.32	12.12	73	36782	71751	70819838
Polydipsia	13.31	12.12	16	36839	5972	70885617
Vulvovaginal inflammation	13.19	12.12	6	36849	486	70891103
Pain in jaw	13.18	12.12	3	36852	42666	70848923
Abdominal discomfort	13.16	12.12	62	36793	214596	70676993
Folliculitis	13.13	12.12	3	36852	42567	70849022
Ill-defined disorder	13.11	12.12	6	36849	54735	70836854
Leukocyturia	13.08	12.12	9	36846	1628	70889961
Oliguria	13.06	12.12	26	36829	15025	70876564
Hypocalciuria	13.00	12.12	3	36852	25	70891564
Iron deficiency	12.97	12.12	18	36837	7738	70883851
Lung neoplasm malignant	12.92	12.12	35	36820	24707	70866882
Duodenal ulcer	12.79	12.12	26	36829	15254	70876335
Dyspnoea exertional	12.76	12.12	77	36778	78353	70813236
Poor dental condition	12.75	12.12	6	36849	525	70891064
Ephelides	12.74	12.12	4	36851	115	70891474
Pyelonephritis acute	12.69	12.12	15	36840	5502	70886087
Brain stem haematoma	12.61	12.12	4	36851	119	70891470
Nail injury	12.57	12.12	6	36849	542	70891047
Lupus nephritis	12.53	12.12	11	36844	2843	70888746
Erectile dysfunction	12.46	12.12	24	36831	13538	70878051
Blood urea increased	12.39	12.12	52	36803	45857	70845732
Therapy non-responder	12.38	12.12	13	36842	76902	70814687
Thirst	12.35	12.12	25	36830	14624	70876965

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C03BA11	CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, EXCL. THIAZIDES Sulfonamides, plain
ATC	C09BX01	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations
ATC	C10BX13	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
FDA PE	N0000175359	Increased Diuresis
FDA EPC	N0000175420	Thiazide-like Diuretic
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004232	Diuretics
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D045283	Natriuretic Agents
MeSH PA	D049993	Sodium Chloride Symporter Inhibitors
CHEBI has role	CHEBI:35498	diuretics
CHEBI has role	CHEBI:35674	antihypertensive drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Edema	indication	267038008
Anuria	contraindication	2472002	DOID:2983
Dehydration	contraindication	34095006
Hyperuricemia	contraindication	35885006	DOID:1920
Hypokalemia	contraindication	43339004
Sympathectomy	contraindication	57071006
Acute nephropathy	contraindication	58574008
Hyperparathyroidism	contraindication	66999008	DOID:13543
Diabetes mellitus	contraindication	73211009	DOID:9351
Oliguria	contraindication	83128009
Hyponatremia	contraindication	89627008
Gout	contraindication	90560007	DOID:13189
Disease of liver	contraindication	235856003	DOID:409

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.53	acidic
pKa2	9.54	acidic
pKa3	5.52	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Solute carrier family 12 member 3	Transporter	P55017	S12A3_HUMAN	INHIBITOR	A2	7.54	WOMBAT-PK	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Kd	5	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	6.67	CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	7.44	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	8	CHEMBL
Potassium voltage-gated channel subfamily KQT member 1	Ion channel	P51787	KCNQ1_HUMAN				WOMBAT-PK
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	6.05	CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	6.56	CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN		Ki	9.64	CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Kd	6.60	CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN		Ki	5.31	CHEMBL
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Kd	6.70	CHEMBL
Carbonic anhydrase 13	Enzyme	Q8N1Q1	CAH13_HUMAN		Kd	7	CHEMBL
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	5.54	DRUG MATRIX
Carbonic anhydrase 13	Enzyme		CAH13_MOUSE		Ki	7.89	CHEMBL

External reference:

ID	Source
4018746	VUID
N0000147050	NUI
D00345	KEGG_DRUG
180004-24-4	SECONDARY_CAS_RN
4018746	VANDF
C0021186	UMLSCUI
CHEBI:5893	CHEBI
BL1	PDB_CHEM_ID
CHEMBL406	ChEMBL_ID
DB00808	DRUGBANK_ID
D007190	MESH_DESCRIPTOR_UI
3702	PUBCHEM_CID
7203	IUPHAR_LIGAND_ID
3333	INN_ID
F089I0511L	UNII
5764	RXNORM
2360	MMSL
4873	MMSL
d00260	MMSL
002313	NDDF
387419003	SNOMEDCT_US
725661001	SNOMEDCT_US
74213004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2571	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2571	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2597	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2597	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0069	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0080	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	21695-576	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-348	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-349	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	51407-024	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	51407-025	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	62559-510	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	62559-511	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	63629-1953	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	63629-1953	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	63629-1954	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	63629-1954	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	19 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	68151-1294	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	68788-7247	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	68788-7247	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	71335-1541	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	19 sections