codeine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
725 76-57-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • codeine phosphate anhydrous
  • codeine anhydrous
  • codeine monohydrate
  • codeine
  • (-)-Codeine
  • morphine monomethyl ether
  • methylmorphine
  • codeine phosphate
  • codeine sulfate
  • codeine phosphate hydrate
  • codeine polistirex
  • N-Methylmorphine
An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.
  • Molecular weight: 299.37
  • Formula: C18H21NO3
  • CLOGP: 0.98
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 41.93
  • ALOGS: -2.72
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 435 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 20.04 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 15 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 21, 1952 FDA ANI PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 4657.98 10.23 4107 104246 239718 46337991
Toxicity to various agents 372.21 10.23 1208 107145 210558 46367151
Blood parathyroid hormone decreased 277.52 10.23 155 108198 4226 46573483
Granuloma skin 253.72 10.23 135 108218 3335 46574374
Panniculitis 247.09 10.23 158 108195 5546 46572163
Drug abuse 230.43 10.23 476 107877 62932 46514777
Contrast media allergy 199.83 10.23 93 108260 1706 46576003
Skin necrosis 178.60 10.23 153 108200 8451 46569258
Rheumatoid nodule 178.34 10.23 156 108197 8864 46568845
Drug intolerance 162.47 10.23 724 107629 146325 46431384
Rheumatoid arthritis 158.33 10.23 1026 107327 239189 46338520
Tenosynovitis 138.68 10.23 125 108228 7390 46570319
Ulcer 137.11 10.23 185 108168 17207 46560502
Peripheral swelling 129.54 10.23 715 107638 157356 46420353
Basal cell carcinoma 126.43 10.23 194 108159 20293 46557416
Contraindicated product administered 124.04 10.23 438 107915 79509 46498200
Drug dependence 111.11 10.23 180 108173 19721 46557988
Hypercalcaemia 108.97 10.23 184 108169 20862 46556847
Lower respiratory tract infection 104.37 10.23 323 108030 54766 46522943
Enthesopathy 100.61 10.23 85 108268 4605 46573104
Skin ulcer 97.73 10.23 226 108127 32232 46545477
Soft tissue disorder 94.21 10.23 78 108275 4108 46573601
Joint swelling 93.60 10.23 683 107670 165390 46412319
Drug tolerance decreased 92.76 10.23 68 108285 2991 46574718
Loss of personal independence in daily activities 92.76 10.23 318 108035 56865 46520844
Rash 91.09 10.23 1243 107110 355269 46222440
Drug eruption 88.08 10.23 169 108184 21160 46556549
Substance abuse 84.25 10.23 73 108280 4094 46573615
Infusion related reaction 82.28 10.23 457 107896 100751 46476958
Poisoning deliberate 79.39 10.23 95 108258 7831 46569878
Rash pruritic 77.12 10.23 252 108101 43963 46533746
White blood cell count abnormal 76.78 10.23 76 108277 5056 46572653
Injection site erythema 75.78 10.23 39 108314 74388 46503321
Product dose omission issue 73.20 10.23 178 108175 168342 46409367
Anaphylactic reaction 73.10 10.23 280 108073 52832 46524877
Herpes zoster 70.23 10.23 328 108025 67544 46510165
Inflammation 69.48 10.23 260 108093 48521 46529188
Miosis 67.02 10.23 80 108273 6577 46571132
Analgesic drug level increased 66.23 10.23 42 108311 1452 46576257
Death 63.07 10.23 488 107865 335060 46242649
Lip swelling 62.82 10.23 164 108189 25231 46552478
Pancytopenia 62.54 10.23 63 108290 84995 46492714
Obliterative bronchiolitis 61.98 10.23 43 108310 1732 46575977
Injection site pain 61.42 10.23 96 108257 107056 46470653
Asphyxia 60.31 10.23 68 108285 5258 46572451
Cardiac failure congestive 59.77 10.23 75 108278 91675 46486034
Somnolence 59.16 10.23 589 107764 155932 46421777
Red blood cell sedimentation rate increased 56.81 10.23 148 108205 22741 46554968
Wrong technique in product usage process 56.17 10.23 28 108325 54394 46523315
Prescription form tampering 54.11 10.23 28 108325 652 46577057
Haematemesis 52.78 10.23 167 108186 28639 46549070
Synovitis 52.44 10.23 280 108073 60795 46516914
Malaise 52.30 10.23 1068 107285 330164 46247545
Device expulsion 51.76 10.23 3 108350 27539 46550170
Musculoskeletal stiffness 49.52 10.23 393 107960 97600 46480109
Liver function test abnormal 49.06 10.23 226 108127 46261 46531448
Bone marrow failure 48.24 10.23 6 108347 29663 46548046
Wrist surgery 47.52 10.23 27 108326 761 46576948
Asthenia 47.13 10.23 478 107875 310597 46267112
Disease progression 46.64 10.23 88 108265 91212 46486497
Anaemia 45.69 10.23 377 107976 255402 46322307
Platelet count decreased 45.52 10.23 103 108250 99921 46477788
Swollen tongue 45.16 10.23 160 108193 29072 46548637
Patient uncooperative 44.88 10.23 16 108337 141 46577568
Serotonin syndrome 44.00 10.23 140 108213 24080 46553629
Bradypnoea 43.61 10.23 44 108309 2995 46574714
Overdose 42.58 10.23 392 107961 101587 46476122
Red blood cell sedimentation rate 41.92 10.23 34 108319 1739 46575970
Oedema peripheral 41.46 10.23 210 108143 159496 46418213
Hospitalisation 41.08 10.23 52 108301 63333 46514376
Hypersensitivity 41.07 10.23 531 107822 149790 46427919
Abnormal weight gain 40.68 10.23 31 108322 1447 46576262
Therapeutic product effect decreased 40.48 10.23 329 108024 82272 46495437
Completed suicide 39.68 10.23 515 107838 145405 46432304
Blister 39.26 10.23 206 108147 44425 46533284
Gastric pH decreased 37.54 10.23 18 108335 354 46577355
Renal papillary necrosis 37.35 10.23 16 108337 239 46577470
Muscle injury 37.19 10.23 51 108302 4815 46572894
Pneumonia viral 37.09 10.23 60 108293 6564 46571145
C-reactive protein increased 37.07 10.23 248 108105 58342 46519367
Labile blood pressure 36.81 10.23 31 108322 1672 46576037
Derealisation 36.66 10.23 23 108330 780 46576929
Confusional state 36.47 10.23 547 107806 159345 46418364
Mental status changes 35.82 10.23 22 108331 38066 46539643
Pancreatic fibrosis 35.82 10.23 12 108341 86 46577623
Injection site swelling 35.61 10.23 25 108328 40302 46537407
White blood cell count decreased 35.52 10.23 137 108216 112094 46465615
Treatment failure 34.99 10.23 350 108003 92737 46484972
Toxicologic test abnormal 34.40 10.23 21 108332 678 46577031
Respiratory depression 34.06 10.23 80 108273 11520 46566189
Arthralgia 33.99 10.23 1096 107257 363507 46214202
Arteriosclerosis coronary artery 32.90 10.23 64 108289 8092 46569617
Renal failure 32.62 10.23 144 108209 113450 46464259
Precancerous cells present 32.52 10.23 25 108328 1182 46576527
Haematocrit decreased 31.94 10.23 21 108332 35036 46542673
Hallucination 31.94 10.23 212 108141 49739 46527970
Depersonalisation/derealisation disorder 31.87 10.23 23 108330 987 46576722
Febrile neutropenia 31.58 10.23 113 108240 94514 46483195
Blood pressure systolic increased 31.15 10.23 141 108212 28646 46549063
Necrosis ischaemic 30.75 10.23 21 108332 824 46576885
Anti-cyclic citrullinated peptide antibody positive 30.61 10.23 106 108247 19039 46558670
Pericarditis 30.37 10.23 123 108230 23804 46553905
Sepsis 30.32 10.23 188 108165 135826 46441883
Arthropathy 30.17 10.23 315 108038 84385 46493324
Device related thrombosis 30.01 10.23 24 108329 1203 46576506
C-reactive protein abnormal 29.96 10.23 113 108240 21157 46556552
Tongue disorder 29.60 10.23 57 108296 7153 46570556
Pituitary tumour benign 29.14 10.23 27 108326 1654 46576055
Needle issue 29.05 10.23 50 108303 5754 46571955
Neutropenia 28.86 10.23 204 108149 143000 46434709
Haemoglobin decreased 28.86 10.23 178 108175 128771 46448938
Duodenal ulcer perforation 28.72 10.23 62 108291 8440 46569269
Sleep disorder due to general medical condition, insomnia type 28.65 10.23 47 108306 5202 46572507
Blood pressure systolic decreased 28.19 10.23 47 108306 5271 46572438
Dehydration 28.06 10.23 236 108117 159304 46418405
Oral pain 27.99 10.23 123 108230 24674 46553035
Drug use disorder 27.75 10.23 33 108320 2702 46575007
General physical health deterioration 26.85 10.23 158 108195 115611 46462098
Opiates positive 26.82 10.23 13 108340 262 46577447
Deep vein thrombosis 26.79 10.23 95 108258 79678 46498031
Respiratory failure 26.73 10.23 121 108232 94695 46483014
Folliculitis 26.65 10.23 50 108303 6153 46571556
Finger deformity 26.54 10.23 45 108308 5117 46572592
Visceral congestion 25.79 10.23 13 108340 286 46577423
Small cell carcinoma 25.46 10.23 11 108342 168 46577541
Blood glucose increased 25.38 10.23 84 108269 71929 46505780
Pulmonary hypertension 24.94 10.23 28 108325 35965 46541744
Chronic obstructive pulmonary disease 24.89 10.23 61 108292 57572 46520137
Accidental exposure to product 24.70 10.23 9 108344 21072 46556637
Withdrawal syndrome 24.44 10.23 95 108258 18039 46559670
Injection site pruritus 24.32 10.23 34 108319 39709 46538000
H1N1 influenza 24.12 10.23 23 108330 1461 46576248
Retroperitoneal fibrosis 24.11 10.23 13 108340 330 46577379
Distributive shock 23.98 10.23 15 108338 506 46577203
Computerised tomogram thorax abnormal 23.86 10.23 22 108331 1339 46576370
Visual impairment 23.74 10.23 248 108105 66441 46511268
Blood creatinine increased 23.70 10.23 94 108259 76309 46501400
Coma 23.19 10.23 222 108131 58127 46519582
Diaphragmatic rupture 23 10.23 11 108342 215 46577494
Cerebrovascular accident 22.85 10.23 139 108214 100900 46476809
Product quality issue 22.31 10.23 30 108323 35618 46542091
Cardiomyopathy 22.26 10.23 5 108348 16068 46561641
Swelling face 22.15 10.23 204 108149 52855 46524854
Atrial fibrillation 22.14 10.23 145 108208 103445 46474264
Pain 22.08 10.23 1334 107019 475614 46102095
Muscle relaxant therapy 21.93 10.23 9 108344 120 46577589
Tendonitis 21.92 10.23 78 108275 14199 46563510
Blood potassium decreased 21.89 10.23 34 108319 38029 46539680
Metastases to eye 21.73 10.23 9 108344 123 46577586
Plasma cell myeloma 21.72 10.23 44 108309 44434 46533275
Pneumonia streptococcal 21.55 10.23 23 108330 1672 46576037
Accidental overdose 21.49 10.23 98 108255 19968 46557741
Septic shock 21.47 10.23 66 108287 57827 46519882
Helicobacter infection 21.46 10.23 68 108285 11668 46566041
Loss of employment 21.43 10.23 20 108333 1236 46576473
Laryngeal dyspnoea 21.41 10.23 9 108344 128 46577581
Fear of eating 21.13 10.23 12 108341 338 46577371
Hand deformity 21.06 10.23 145 108208 34429 46543280
Product use issue 20.87 10.23 322 108031 94322 46483387
Fall 20.84 10.23 593 107760 328504 46249205
Depression 20.79 10.23 274 108079 169830 46407879
Hyperhidrosis 20.52 10.23 306 108047 89002 46488707
Stomatitis 20.23 10.23 245 108108 68052 46509657
Duodenal ulcer repair 20.23 10.23 7 108346 56 46577653
Thrombocytopenia 20.16 10.23 192 108161 126389 46451320
Treatment noncompliance 19.67 10.23 24 108329 29707 46548002
Coronary artery disease 19.55 10.23 30 108323 33722 46543987
Device issue 19.55 10.23 11 108342 19969 46557740
Alanine aminotransferase increased 19.52 10.23 301 108052 88150 46489559
Neutropenic sepsis 19.50 10.23 68 108285 12256 46565453
Derailment 19.41 10.23 7 108346 64 46577645
Fibromyalgia 19.37 10.23 148 108205 36315 46541394
Protein C increased 19.29 10.23 9 108344 166 46577543
No adverse event 19.28 10.23 31 108322 34200 46543509
Hepatic infiltration eosinophilic 19.26 10.23 6 108347 33 46577676
Thiopurine methyltransferase decreased 19.20 10.23 11 108342 315 46577394
Feeling of body temperature change 19.18 10.23 35 108318 4217 46573492
Postmortem blood drug level abnormal 19.14 10.23 11 108342 317 46577392
Dependence 19.10 10.23 23 108330 1908 46575801
Mitral valve incompetence 19.00 10.23 10 108343 18842 46558867
Mouth swelling 18.75 10.23 32 108321 3657 46574052
Emergency care examination abnormal 18.70 10.23 5 108348 14 46577695
Soft tissue swelling 18.70 10.23 16 108337 882 46576827
Body temperature decreased 18.69 10.23 71 108282 13338 46564371
Cogwheel rigidity 18.56 10.23 20 108333 1470 46576239
Blood urea increased 18.37 10.23 19 108334 25333 46552376
Vomiting 18.31 10.23 1252 107101 451542 46126167
Cholelithiasis 18.27 10.23 39 108314 38642 46539067
Abdominal pain 18.24 10.23 679 107674 229352 46348357
Red blood cell count decreased 17.95 10.23 30 108323 32593 46545116
Drug resistance 17.82 10.23 9 108344 17359 46560350
Blood cholesterol increased 17.80 10.23 156 108197 39857 46537852
Gastrointestinal stoma complication 17.79 10.23 20 108333 1541 46576168
Fatigue 17.76 10.23 1196 107157 607501 45970208
Acute respiratory failure 17.76 10.23 25 108328 29113 46548596
Unevaluable event 17.58 10.23 52 108301 46123 46531586
Pericardial effusion 17.56 10.23 20 108333 25523 46552186
Transient ischaemic attack 17.50 10.23 34 108319 34869 46542840
Gastrooesophageal reflux disease 17.48 10.23 101 108252 74243 46503466
Intestinal fibrosis 17.43 10.23 8 108345 142 46577567
Change of bowel habit 17.39 10.23 21 108332 1747 46575962
Pulmonary function test abnormal 17.23 10.23 18 108335 1277 46576432
Diabetes mellitus 17.22 10.23 59 108294 50006 46527703
Skin lesion 17.21 10.23 22 108331 26691 46551018
Swelling 17.17 10.23 394 107959 124117 46453592
Chronic kidney disease 17.07 10.23 44 108309 40827 46536882
Hepatic ischaemia 17.07 10.23 12 108341 494 46577215
Oesophageal pain 16.99 10.23 25 108328 2518 46575191
Renal impairment 16.97 10.23 102 108251 74270 46503439
Premature labour 16.73 10.23 61 108292 11238 46566471
Procedural anxiety 16.65 10.23 12 108341 514 46577195
Premature delivery 16.61 10.23 16 108337 22053 46555656
Urinary tract infection 16.56 10.23 387 107966 219879 46357830
Dissociation 16.39 10.23 21 108332 1856 46575853
Tendon operation 16.38 10.23 10 108343 323 46577386
Multiple sclerosis relapse 16.35 10.23 47 108306 42078 46535631
Fluid retention 16.34 10.23 62 108291 50984 46526725
Intentional overdose 16.30 10.23 226 108127 64718 46512991
Beta haemolytic streptococcal infection 16.28 10.23 21 108332 1868 46575841
Gait disturbance 16.28 10.23 447 107906 144816 46432893
Foetal exposure during pregnancy 16.26 10.23 29 108324 30718 46546991
Cardiac failure 16.04 10.23 114 108239 79834 46497875
Injection site urticaria 16.03 10.23 4 108349 11963 46565746
Wheezing 16.02 10.23 192 108161 53194 46524515
White blood cell count increased 15.98 10.23 51 108302 44168 46533541
Injection site warmth 15.93 10.23 6 108347 13766 46563943
Oedema 15.83 10.23 91 108262 66980 46510729
Osteonecrosis 15.78 10.23 22 108331 25722 46551987
Sensitisation 15.71 10.23 13 108340 684 46577025
Hypersensitivity vasculitis 15.68 10.23 32 108321 4189 46573520
Benzodiazepine drug level increased 15.63 10.23 8 108345 182 46577527
Urticaria 15.62 10.23 371 107982 117521 46460188
Induced abortion failed 15.61 10.23 9 108344 261 46577448
Thrombosis 15.53 10.23 72 108281 55997 46521712
Myocardial fibrosis 15.53 10.23 12 108341 572 46577137
Pain in jaw 15.50 10.23 42 108311 38330 46539379
Feeling of despair 15.46 10.23 20 108333 1785 46575924
Injection site reaction 15.39 10.23 58 108295 47791 46529918
Dermatitis allergic 15.37 10.23 64 108289 12539 46565170
Pleural effusion 15.35 10.23 121 108232 82831 46494878
Hallucinations, mixed 15.28 10.23 30 108323 3819 46573890
Hot flush 15.16 10.23 51 108302 43466 46534243
Device dislocation 15.06 10.23 17 108336 21785 46555924
Costovertebral angle tenderness 15.04 10.23 6 108347 74 46577635
Drug detoxification 15.02 10.23 8 108345 198 46577511
Dysmetropsia 14.97 10.23 6 108347 75 46577634
Maternal exposure during pregnancy 14.90 10.23 159 108194 102390 46475319
Myelodysplastic syndrome 14.88 10.23 9 108344 15702 46562007
Ileus 14.87 10.23 7 108346 14057 46563652
Ascites 14.81 10.23 40 108313 36544 46541165
Alveolar rhabdomyosarcoma 14.79 10.23 5 108348 37 46577672
Blood count abnormal 14.61 10.23 12 108341 17866 46559843
Agranulocytosis 14.58 10.23 18 108335 22167 46555542
Peritonitis 14.48 10.23 16 108337 20698 46557011
Limb operation 14.46 10.23 27 108326 3311 46574398
Neuropathy peripheral 14.41 10.23 138 108215 90755 46486954
Weight decreased 14.34 10.23 376 107977 210473 46367236
Mite allergy 14.24 10.23 10 108343 411 46577298
Therapy cessation 14.18 10.23 25 108328 26604 46551105
Stubbornness 14.10 10.23 8 108345 225 46577484
Fluid overload 14.05 10.23 26 108327 27159 46550550
Lethargy 14.05 10.23 181 108172 50990 46526719
Intestinal strangulation 13.98 10.23 6 108347 90 46577619
Device related infection 13.90 10.23 17 108336 21024 46556685
Uveal melanoma 13.87 10.23 4 108349 16 46577693
Blood triglycerides increased 13.85 10.23 5 108348 11778 46565931
Infective pulmonary exacerbation of cystic fibrosis 13.74 10.23 4 108349 10803 46566906
Bacteraemia 13.60 10.23 8 108345 14171 46563538
Carcinoid crisis 13.57 10.23 8 108345 242 46577467
Toxic shock syndrome streptococcal 13.41 10.23 6 108347 100 46577609
Cerebral infarction 13.31 10.23 21 108332 23345 46554364
Respiratory rate decreased 13.28 10.23 25 108328 3085 46574624
Fear-related avoidance of activities 13.25 10.23 6 108347 103 46577606
Sphincter of Oddi dysfunction 13.23 10.23 9 108344 351 46577358
Tuberculosis 13.21 10.23 53 108300 10212 46567497
Disease recurrence 13.21 10.23 14 108339 18457 46559252
Limb mass 13.16 10.23 22 108331 2472 46575237
Red blood cell nucleated morphology present 13.15 10.23 4 108349 20 46577689
Vaccination site joint pain 13.13 10.23 3 108350 3 46577706
Irritable bowel syndrome 13.02 10.23 74 108279 16441 46561268
Cholangiectasis acquired 12.99 10.23 4 108349 21 46577688
Injection site bruising 12.94 10.23 41 108312 35595 46542114
Fungal infection 12.94 10.23 31 108322 29489 46548220
Respiratory distress 12.84 10.23 35 108318 31881 46545828
Lymphopenia 12.83 10.23 10 108343 15283 46562426
Product complaint 12.83 10.23 6 108347 12095 46565614
Parosmia 12.76 10.23 29 108324 4087 46573622
Pubic pain 12.73 10.23 5 108348 59 46577650
Abortion induced 12.68 10.23 4 108349 10256 46567453
Anterograde amnesia 12.66 10.23 9 108344 377 46577332
Off label use 12.66 10.23 737 107616 379104 46198605
Seizure 12.65 10.23 205 108148 122849 46454860
Premature baby 12.65 10.23 14 108339 18098 46559611
Caesarean section 12.54 10.23 12 108341 16591 46561118
Hypotension 12.53 10.23 428 107925 232161 46345548
Gallbladder cholesterolosis 12.50 10.23 12 108341 769 46576940
Urine output decreased 12.49 10.23 55 108298 11042 46566667
Cholesteatoma 12.47 10.23 6 108347 119 46577590
Oral contusion 12.44 10.23 5 108348 63 46577646
Infrequent bowel movements 12.30 10.23 14 108339 1094 46576615
COVID-19 12.28 10.23 15 108338 18560 46559149
Adverse drug reaction 12.27 10.23 57 108296 44305 46533404
Exposure during pregnancy 12.24 10.23 177 108176 108035 46469674
Anxiety 12.23 10.23 325 108028 181632 46396077
Ill-defined disorder 12.14 10.23 105 108248 26722 46550987
Shock 12.10 10.23 20 108333 21825 46555884
Influenza like illness 12.09 10.23 81 108272 57489 46520220
Escherichia infection 12.04 10.23 5 108348 10812 46566897
Hyperprolinaemia 12.02 10.23 4 108349 28 46577681
Jaw clicking 12.02 10.23 4 108349 28 46577681
Lung infiltration 12.01 10.23 9 108344 14034 46563675
Bulimia nervosa 11.94 10.23 10 108343 535 46577174
Haemophilus test positive 11.92 10.23 3 108350 6 46577703
Ataxia 11.82 10.23 9 108344 13921 46563788
Musculoskeletal disorder 11.82 10.23 69 108284 15476 46562233
Pyroglutamate increased 11.81 10.23 9 108344 420 46577289
Antisocial behaviour 11.81 10.23 7 108346 214 46577495
Acute interstitial pneumonitis 11.80 10.23 11 108342 679 46577030
Multiple sclerosis 11.70 10.23 25 108328 24766 46552943
Suspected counterfeit product 11.65 10.23 8 108345 317 46577392
Hernia 11.64 10.23 49 108304 9646 46568063
Duodenal ulcer 11.57 10.23 40 108313 7178 46570531
External ear disorder 11.56 10.23 4 108349 32 46577677
Cranial sutures widening 11.56 10.23 4 108349 32 46577677
Acute chest syndrome 11.55 10.23 10 108343 560 46577149
Pneumocystis jirovecii pneumonia 11.54 10.23 11 108342 15237 46562472
Drug diversion 11.51 10.23 12 108341 849 46576860
Meningorrhagia 11.47 10.23 6 108347 143 46577566
Neurotoxicity 11.47 10.23 9 108344 13708 46564001
Progressive multifocal leukoencephalopathy 11.46 10.23 6 108347 11340 46566369
Strabismus congenital 11.45 10.23 4 108349 33 46577676
Cholecystitis chronic 11.45 10.23 5 108348 10494 46567215
Deformity 11.44 10.23 40 108313 7217 46570492
Peritonitis bacterial 11.38 10.23 3 108350 8650 46569059
Lip infection 11.36 10.23 5 108348 80 46577629
Electrolyte imbalance 11.29 10.23 14 108339 17212 46560497
Sacroiliitis 11.27 10.23 19 108334 2150 46575559
Acute myeloid leukaemia 11.23 10.23 12 108341 15766 46561943
Eosinophilia 11.21 10.23 17 108336 19200 46558509
Hyperlipidaemia 11.20 10.23 16 108337 18523 46559186
Blood loss anaemia 11.19 10.23 3 108350 8554 46569155
Muscular weakness 11.18 10.23 148 108205 91696 46486013
Dermal sinus 11.05 10.23 4 108349 37 46577672
Device malfunction 10.90 10.23 9 108344 13365 46564344
Agitation 10.89 10.23 185 108168 55230 46522479
Cafe au lait spots 10.86 10.23 4 108349 39 46577670
Neoplasm malignant 10.84 10.23 24 108329 23475 46554234
Schizophrenia 10.83 10.23 44 108309 8524 46569185
Intestinal ulcer perforation 10.83 10.23 3 108350 10 46577699
Haemophagocytic lymphohistiocytosis 10.77 10.23 3 108350 8339 46569370
Libido increased 10.75 10.23 11 108342 761 46576948
Underdose 10.75 10.23 18 108335 19540 46558169
Therapy non-responder 10.72 10.23 54 108299 41098 46536611
Product prescribing issue 10.72 10.23 12 108341 920 46576789
Abnormal palmar/plantar creases 10.60 10.23 4 108349 42 46577667
Periorbital cellulitis 10.60 10.23 9 108344 491 46577218
Sinusitis 10.59 10.23 225 108128 129543 46448166
Restless legs syndrome 10.58 10.23 68 108285 15775 46561934
Pancreatitis acute 10.56 10.23 96 108257 24776 46552933
Staphylococcal infection 10.47 10.23 45 108308 35726 46541983
Thyroid adenoma 10.44 10.23 6 108347 173 46577536
Alanine aminotransferase abnormal 10.40 10.23 20 108333 2507 46575202
Naevus haemorrhage 10.35 10.23 5 108348 100 46577609
Hyperglycaemia 10.34 10.23 44 108309 35027 46542682
Lactic acidosis 10.33 10.23 42 108311 33867 46543842
Emphysema 10.28 10.23 45 108308 9009 46568700
Urinary retention 10.27 10.23 99 108254 25962 46551747
Tricuspid valve incompetence 10.26 10.23 10 108343 13707 46564002
Injection site induration 10.25 10.23 3 108350 8076 46569633

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1550.61 10.57 1164 45312 80908 29825094
Toxicity to various agents 1322.62 10.57 1492 44984 175691 29730311
Drug hypersensitivity 420.02 10.57 524 45952 67995 29838007
Substance abuse 241.06 10.57 145 46331 6895 29899107
Prescription form tampering 228.21 10.57 68 46408 502 29905500
Overdose 218.18 10.57 434 46042 83903 29822099
Drug dependence 165.24 10.57 184 46292 21111 29884891
Intentional product misuse 155.40 10.57 228 46248 34439 29871563
Intentional overdose 92.45 10.57 201 46275 41280 29864722
Poisoning 84.25 10.57 96 46380 11286 29894716
Poisoning deliberate 75.51 10.57 67 46409 5837 29900165
Drug ineffective 71.78 10.57 279 46197 340108 29565894
Completed suicide 71.63 10.57 325 46151 99167 29806835
Lower respiratory tract infection 65.95 10.57 135 46341 26579 29879423
Asphyxia 58.56 10.57 56 46420 5369 29900633
Depressed level of consciousness 50.45 10.57 152 46324 38070 29867932
Drug use disorder 50.00 10.57 41 46435 3207 29902795
Miosis 43.59 10.57 57 46419 7719 29898283
Respiratory depression 43.54 10.57 70 46406 11433 29894569
Duodenal ulcer perforation 40.91 10.57 28 46448 1664 29904338
Somnolence 38.16 10.57 269 46207 96494 29809508
Myocardial infarction 33.96 10.57 92 46384 125533 29780469
Nightmare 33.37 10.57 64 46412 12012 29893990
Malaise 32.60 10.57 399 46077 166563 29739439
Off label use 32.02 10.57 241 46235 249049 29656953
Bradypnoea 31.15 10.57 25 46451 1896 29904106
Respiratory arrest 31.04 10.57 108 46368 29150 29876852
Poor feeding infant 30.90 10.57 14 46462 367 29905635
Prescription drug used without a prescription 30.79 10.57 21 46455 1241 29904761
Analgesic drug level increased 30.72 10.57 16 46460 573 29905429
Pseudoporphyria 28.77 10.57 12 46464 256 29905746
Peripheral circulatory failure 27.94 10.57 11 46465 201 29905801
Coma scale abnormal 27.60 10.57 30 46446 3346 29902656
Neutropenic sepsis 27.37 10.57 57 46419 11352 29894650
Chronic gastrointestinal bleeding 25.81 10.57 11 46465 248 29905754
Chemical poisoning 25.66 10.57 9 46467 117 29905885
Anaemia 24.85 10.57 205 46271 207787 29698215
Perineal pain 24.77 10.57 14 46462 591 29905411
Multiple organ dysfunction syndrome 24.35 10.57 38 46438 63449 29842553
Cytomegalovirus infection 23.88 10.57 4 46472 23670 29882332
Calcium deficiency 23.67 10.57 9 46467 149 29905853
Pulmonary congestion 23.42 10.57 56 46420 12231 29893771
Pulmonary oedema 23.38 10.57 132 46344 43843 29862159
Agitated depression 23.24 10.57 10 46466 231 29905771
Mouth ulceration 23.15 10.57 51 46425 10558 29895444
Sepsis 23.06 10.57 133 46343 146262 29759740
Spinal cord infection 23.03 10.57 9 46467 161 29905841
Cardiac failure congestive 22.66 10.57 62 46414 84345 29821657
Drug interaction 22.33 10.57 434 46042 199134 29706868
Anal ulcer 22.27 10.57 13 46463 584 29905418
Mouth swelling 22.16 10.57 19 46457 1580 29904422
Product dose omission issue 21.93 10.57 71 46405 91560 29814442
Otospondylomegaepiphyseal dysplasia 21.53 10.57 8 46468 124 29905878
Febrile neutropenia 21.38 10.57 89 46387 106604 29799398
Drug resistance 21.22 10.57 3 46473 20130 29885872
Lip swelling 21.05 10.57 55 46421 12689 29893313
Liver function test abnormal 20.67 10.57 99 46377 30851 29875151
Weight decrease neonatal 20.03 10.57 10 46466 327 29905675
Nervous system neoplasm 19.93 10.57 8 46468 154 29905848
Analgesic drug level above therapeutic 19.86 10.57 9 46467 236 29905766
Swelling face 19.72 10.57 75 46401 21129 29884873
Cardio-respiratory arrest 19.55 10.57 154 46322 57152 29848850
Pyrexia 19.39 10.57 331 46145 294158 29611844
Orthostatic hypotension 19.24 10.57 81 46395 23898 29882104
Alice in wonderland syndrome 19.14 10.57 5 46471 21 29905981
Anal fissure 19.12 10.57 21 46455 2370 29903632
General physical health deterioration 19.02 10.57 85 46391 99859 29806143
Overgrowth bacterial 18.92 10.57 7 46469 107 29905895
Renal failure 18.82 10.57 120 46356 128846 29777156
Morganella infection 18.78 10.57 10 46466 375 29905627
Ulcer 18.77 10.57 36 46440 6755 29899247
Arteriosclerosis coronary artery 18.22 10.57 48 46428 11128 29894874
Accidental overdose 18.13 10.57 66 46410 18209 29887793
Gangrene neonatal 17.79 10.57 8 46468 206 29905796
Disease progression 17.68 10.57 64 46412 79810 29826192
Osmolar gap abnormal 17.01 10.57 5 46471 35 29905967
Genitalia external ambiguous 16.85 10.57 8 46468 234 29905768
Phlebosclerosis 16.84 10.57 7 46469 148 29905854
Exposure via breast milk 16.54 10.57 16 46460 1556 29904446
Blood pressure fluctuation 16.35 10.57 62 46414 17441 29888561
Linear IgA disease 16.28 10.57 16 46460 1586 29904416
Vomiting 16.20 10.57 451 46025 219367 29686635
Withdrawal syndrome 16.04 10.57 46 46430 11204 29894798
Idiopathic pulmonary fibrosis 15.72 10.57 25 46451 4044 29901958
Rhinalgia 15.71 10.57 9 46467 390 29905612
Gastrointestinal mucosa hyperaemia 15.50 10.57 7 46469 182 29905820
Inferior vena cava dilatation 15.19 10.57 7 46469 191 29905811
Bronchial haemorrhage 15.15 10.57 11 46465 718 29905284
Sleep deficit 15.14 10.57 9 46467 418 29905584
Secondary hypogonadism 15.09 10.57 8 46468 297 29905705
Congenital bladder anomaly 15.07 10.57 8 46468 298 29905704
Product use in unapproved indication 15.05 10.57 61 46415 73632 29832370
Skin turgor decreased 15.05 10.57 9 46467 423 29905579
Moaning 14.81 10.57 11 46465 744 29905258
Overlap syndrome 14.77 10.57 5 46471 58 29905944
Increased bronchial secretion 14.61 10.57 14 46462 1345 29904657
Apparent life threatening event 14.52 10.57 7 46469 212 29905790
Maternal exposure during breast feeding 14.22 10.57 15 46461 1617 29904385
Anomaly of external ear congenital 14.17 10.57 6 46470 133 29905869
External auditory canal atresia 13.93 10.57 6 46470 139 29905863
Aspartate aminotransferase increased 13.91 10.57 51 46425 63371 29842631
Hospitalisation 13.90 10.57 30 46446 44289 29861713
Platelet count decreased 13.86 10.57 102 46374 106027 29799975
Patient dissatisfaction with treatment 13.85 10.57 5 46471 71 29905931
Accidental poisoning 13.77 10.57 9 46467 495 29905507
Palpitations 13.60 10.57 94 46382 33479 29872523
Foetal hypokinesia 13.51 10.57 8 46468 369 29905633
Gastrointestinal ulcer 13.48 10.57 15 46461 1717 29904285
Depression suicidal 13.45 10.57 13 46463 1263 29904739
Hyponatraemic seizure 13.42 10.57 5 46471 78 29905924
Crystalluria 13.39 10.57 8 46468 375 29905627
Suicide attempt 13.28 10.57 100 46376 36597 29869405
Depressed mood 13.26 10.57 57 46419 16972 29889030
Foaming at mouth 13.25 10.57 10 46466 693 29905309
Therapeutic response decreased 13.22 10.57 11 46465 24338 29881664
Delirium 13.20 10.57 108 46368 40523 29865479
Self-medication 13.14 10.57 17 46459 2277 29903725
Leukopenia 13.09 10.57 44 46432 56115 29849887
Adrenergic syndrome 13.03 10.57 5 46471 85 29905917
Confusional state 13.01 10.57 287 46189 134547 29771455
Treatment noncompliance 12.99 10.57 12 46464 25241 29880761
Coronary artery disease 12.97 10.57 37 46439 49675 29856327
Thrombocytopenia 12.96 10.57 143 46333 136901 29769101
Drug diversion 12.93 10.57 11 46465 905 29905097
Mucosal inflammation 12.92 10.57 17 46459 30477 29875525
Wrong patient received product 12.89 10.57 15 46461 1802 29904200
Injection site pain 12.74 10.57 17 46459 30293 29875709
Paratracheal lymphadenopathy 12.72 10.57 5 46471 91 29905911
Premature baby 12.68 10.57 5 46471 16686 29889316
Cluster headache 12.60 10.57 9 46467 573 29905429
Injection site erythema 12.57 10.57 3 46473 13831 29892171
Mental status changes 12.56 10.57 24 46452 37055 29868947
Clumsiness 12.53 10.57 13 46463 1374 29904628
Neonatal respiratory depression 12.49 10.57 8 46468 425 29905577
Pancytopenia 12.46 10.57 79 46397 84973 29821029
Hyporesponsive to stimuli 12.46 10.57 11 46465 951 29905051
Plasma cell myeloma 12.39 10.57 42 46434 53420 29852582
Intercepted product prescribing error 12.06 10.57 5 46471 105 29905897
Defaecation urgency 11.97 10.57 13 46463 1448 29904554
Skin fragility 11.97 10.57 8 46468 457 29905545
Peripheral artery thrombosis 11.95 10.57 16 46460 2216 29903786
Psychomotor skills impaired 11.86 10.57 15 46461 1964 29904038
Pouchitis 11.62 10.57 9 46467 648 29905354
Drug withdrawal syndrome neonatal 11.58 10.57 19 46457 3156 29902846
Asthenia 11.41 10.57 259 46217 221031 29684971
Atrial fibrillation 11.37 10.57 110 46366 108014 29797988
Medication overuse headache 11.34 10.57 4 46472 53 29905949
Haematocrit decreased 11.18 10.57 19 46457 30680 29875322
Male sexual dysfunction 11.03 10.57 6 46470 235 29905767
Therapy non-responder 10.94 10.57 18 46458 29435 29876567
Visceral congestion 10.84 10.57 8 46468 536 29905466
Ejection fraction decreased 10.80 10.57 5 46471 15170 29890832
Tendon discomfort 10.75 10.57 6 46470 247 29905755
Social problem 10.74 10.57 9 46467 725 29905277
Fat redistribution 10.73 10.57 5 46471 140 29905862
Tooth injury 10.58 10.57 9 46467 741 29905261

Pharmacologic Action:

SourceCodeDescription
ATC R05DA04 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Opium alkaloids and derivatives
ATC N02AA59 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA79 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AJ06 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ07 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ08 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ09 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D000996 Antitussive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35482 narcotic analgesics
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:50266 prodrugs
CHEBI has role CHEBI:51177 cough suppressant
CHEBI has role CHEBI:60606 opioid receptor agonists
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Headache disorder indication 230461009
Sore throat symptom indication 267102003
Influenza-like symptoms indication 315642008
Fever indication 386661006
Tension-type headache indication 398057008
Muscle Spasm with Pain indication
Diarrhea off-label use 62315008
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Goiter contraindication 3716002 DOID:12176
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Constipation contraindication 14760008 DOID:2089
Hyperbilirubinemia contraindication 14783006 DOID:2741
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Lowered convulsive threshold contraindication 19260006
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Disorder of the central nervous system contraindication 23853001 DOID:331
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Body fluid retention contraindication 43498006
Hyperactive behavior contraindication 44548000
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Sedation contraindication 72641008
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Disorder of brain contraindication 81308009 DOID:936
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Acute intermittent porphyria contraindication 234422006 DOID:3890
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pyloric obstruction contraindication 244815007
Sleep automatism contraindication 247962006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Respiratory insufficiency contraindication 409623005
Breastfeeding (mother) contraindication 413712001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003
Acute exacerbation of asthma contraindication 708038006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.38 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST Ki 6.14 CHEMBL CHEMBL
Kappa-type opioid receptor GPCR AGONIST Ki 4.59 CHEMBL
Delta-type opioid receptor GPCR AGONIST Ki 4.28 CHEMBL
Opioid receptor GPCR IC50 8 CHEMBL

External reference:

IDSource
4017509 VUID
N0000145894 NUI
D00195 KEGG_DRUG
6059-47-8 SECONDARY_CAS_RN
4017414 VANDF
4017415 VANDF
4017509 VANDF
4019491 VANDF
C0009214 UMLSCUI
CHEBI:16714 CHEBI
5284371 PUBCHEM_CID
CHEMBL485 ChEMBL_ID
CHEMBL369475 ChEMBL_ID
CHEMBL1201099 ChEMBL_ID
CHEMBL1159819 ChEMBL_ID
CHEMBL1201463 ChEMBL_ID
CHEMBL284671 ChEMBL_ID
CHEMBL4297091 ChEMBL_ID
DB00318 DRUGBANK_ID
D003061 MESH_DESCRIPTOR_UI
1673 IUPHAR_LIGAND_ID
Q830PW7520 UNII
1545976 RXNORM
32159 MMSL
4490 MMSL
4491 MMSL
4492 MMSL
4675 MMSL
4676 MMSL
d00012 MMSL
001550 NDDF
001551 NDDF
001552 NDDF
001553 NDDF
005189 NDDF
1476002 SNOMEDCT_US
261000 SNOMEDCT_US
387494007 SNOMEDCT_US
85990009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fiorinal with Codeine HUMAN PRESCRIPTION DRUG LABEL 4 0023-6010 CAPSULE 30 mg ORAL NDA 36 sections
Codeine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0243 TABLET 15 mg ORAL NDA 32 sections
Codeine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0244 TABLET 30 mg ORAL NDA 32 sections
Codeine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0245 TABLET 60 mg ORAL NDA 32 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0093-0050 TABLET 15 mg ORAL ANDA 27 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0093-0150 TABLET 30 mg ORAL ANDA 27 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0093-0350 TABLET 60 mg ORAL ANDA 27 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0121-0504 SOLUTION 12 mg ORAL ANDA 34 sections
PROMETHAZINE HYDROCHLORIDE AND CODEINE PHOSPHATE HUMAN PRESCRIPTION DRUG LABEL 2 0121-0547 SYRUP 10 mg ORAL ANDA 30 sections
Guaifenesin and Codeine Phosphate HUMAN OTC DRUG LABEL 2 0121-0775 SOLUTION 10 mg ORAL OTC monograph final 16 sections
Promethazine VC with Codeine Oral Solution HUMAN PRESCRIPTION DRUG LABEL 3 0121-0925 SOLUTION 10 mg ORAL ANDA 29 sections
Promethazine with Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0121-0928 SOLUTION 10 mg ORAL ANDA 29 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0121-1008 SOLUTION 30 mg ORAL ANDA 34 sections
Guaifenesin and Codeine Phosphate HUMAN OTC DRUG LABEL 2 0121-1550 SOLUTION 10 mg ORAL OTC monograph final 16 sections
Guaifenesin and Codeine Phosphate HUMAN OTC DRUG LABEL 2 0121-1775 SOLUTION 10 mg ORAL OTC monograph final 16 sections
ACETAMINOPHEN AND CODEINE PHOSPHATE HUMAN PRESCRIPTION DRUG LABEL 2 0406-0483 TABLET 15 mg ORAL ANDA 15 sections
ACETAMINOPHEN AND CODEINE PHOSPHATE HUMAN PRESCRIPTION DRUG LABEL 2 0406-0484 TABLET 30 mg ORAL ANDA 15 sections
ACETAMINOPHEN AND CODEINE PHOSPHATE HUMAN PRESCRIPTION DRUG LABEL 2 0406-0485 TABLET 60 mg ORAL ANDA 15 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0440-7026 TABLET 30 mg ORAL ANDA 31 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0440-7027 TABLET 60 mg ORAL ANDA 31 sections
Butalbital, Aspirin, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0527-1312 CAPSULE 30 mg ORAL ANDA 25 sections
Codeine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0527-1698 TABLET 30 mg ORAL ANDA 32 sections
Codeine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0527-1699 TABLET 60 mg ORAL ANDA 32 sections
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0591-2641 CAPSULE 30 mg ORAL ANDA 27 sections
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0591-3220 CAPSULE 30 mg ORAL NDA AUTHORIZED GENERIC 32 sections
Butalbital, Aspirin, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0591-3546 CAPSULE 30 mg ORAL NDA authorized generic 36 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0603-2337 TABLET 15 mg ORAL ANDA 34 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0603-2338 TABLET 30 mg ORAL ANDA 34 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0603-2339 TABLET 60 mg ORAL ANDA 34 sections
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0603-2553 CAPSULE 30 mg ORAL ANDA 35 sections