codeine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	725	76-57-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: codeine phosphate anhydrous codeine anhydrous codeine monohydrate codeine (-)-Codeine morphine monomethyl ether methylmorphine codeine phosphate codeine sulfate codeine phosphate hydrate codeine polistirex N-Methylmorphine	An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough. Molecular weight: 299.37 Formula: C18H21NO3 CLOGP: 0.98 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 41.93 ALOGS: -2.72 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

codeine phosphate anhydrous
codeine anhydrous
codeine monohydrate
codeine
(-)-Codeine
morphine monomethyl ether
methylmorphine
codeine phosphate
codeine sulfate
codeine phosphate hydrate
codeine polistirex
N-Methylmorphine

An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.

Molecular weight: 299.37
Formula: C18H21NO3
CLOGP: 0.98
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 41.93
ALOGS: -2.72
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.10	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	435 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.10 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	20.04 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	50 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	3.50 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	15 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.70 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	4 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Jan. 21, 1952	FDA	ANI PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	4657.98	10.23	4107	104246	239718	46337991
Toxicity to various agents	372.21	10.23	1208	107145	210558	46367151
Blood parathyroid hormone decreased	277.52	10.23	155	108198	4226	46573483
Granuloma skin	253.72	10.23	135	108218	3335	46574374
Panniculitis	247.09	10.23	158	108195	5546	46572163
Drug abuse	230.43	10.23	476	107877	62932	46514777
Contrast media allergy	199.83	10.23	93	108260	1706	46576003
Skin necrosis	178.60	10.23	153	108200	8451	46569258
Rheumatoid nodule	178.34	10.23	156	108197	8864	46568845
Drug intolerance	162.47	10.23	724	107629	146325	46431384
Rheumatoid arthritis	158.33	10.23	1026	107327	239189	46338520
Tenosynovitis	138.68	10.23	125	108228	7390	46570319
Ulcer	137.11	10.23	185	108168	17207	46560502
Peripheral swelling	129.54	10.23	715	107638	157356	46420353
Basal cell carcinoma	126.43	10.23	194	108159	20293	46557416
Contraindicated product administered	124.04	10.23	438	107915	79509	46498200
Drug dependence	111.11	10.23	180	108173	19721	46557988
Hypercalcaemia	108.97	10.23	184	108169	20862	46556847
Lower respiratory tract infection	104.37	10.23	323	108030	54766	46522943
Enthesopathy	100.61	10.23	85	108268	4605	46573104
Skin ulcer	97.73	10.23	226	108127	32232	46545477
Soft tissue disorder	94.21	10.23	78	108275	4108	46573601
Joint swelling	93.60	10.23	683	107670	165390	46412319
Drug tolerance decreased	92.76	10.23	68	108285	2991	46574718
Loss of personal independence in daily activities	92.76	10.23	318	108035	56865	46520844
Rash	91.09	10.23	1243	107110	355269	46222440
Drug eruption	88.08	10.23	169	108184	21160	46556549
Substance abuse	84.25	10.23	73	108280	4094	46573615
Infusion related reaction	82.28	10.23	457	107896	100751	46476958
Poisoning deliberate	79.39	10.23	95	108258	7831	46569878
Rash pruritic	77.12	10.23	252	108101	43963	46533746
White blood cell count abnormal	76.78	10.23	76	108277	5056	46572653
Injection site erythema	75.78	10.23	39	108314	74388	46503321
Product dose omission issue	73.20	10.23	178	108175	168342	46409367
Anaphylactic reaction	73.10	10.23	280	108073	52832	46524877
Herpes zoster	70.23	10.23	328	108025	67544	46510165
Inflammation	69.48	10.23	260	108093	48521	46529188
Miosis	67.02	10.23	80	108273	6577	46571132
Analgesic drug level increased	66.23	10.23	42	108311	1452	46576257
Death	63.07	10.23	488	107865	335060	46242649
Lip swelling	62.82	10.23	164	108189	25231	46552478
Pancytopenia	62.54	10.23	63	108290	84995	46492714
Obliterative bronchiolitis	61.98	10.23	43	108310	1732	46575977
Injection site pain	61.42	10.23	96	108257	107056	46470653
Asphyxia	60.31	10.23	68	108285	5258	46572451
Cardiac failure congestive	59.77	10.23	75	108278	91675	46486034
Somnolence	59.16	10.23	589	107764	155932	46421777
Red blood cell sedimentation rate increased	56.81	10.23	148	108205	22741	46554968
Wrong technique in product usage process	56.17	10.23	28	108325	54394	46523315
Prescription form tampering	54.11	10.23	28	108325	652	46577057
Haematemesis	52.78	10.23	167	108186	28639	46549070
Synovitis	52.44	10.23	280	108073	60795	46516914
Malaise	52.30	10.23	1068	107285	330164	46247545
Device expulsion	51.76	10.23	3	108350	27539	46550170
Musculoskeletal stiffness	49.52	10.23	393	107960	97600	46480109
Liver function test abnormal	49.06	10.23	226	108127	46261	46531448
Bone marrow failure	48.24	10.23	6	108347	29663	46548046
Wrist surgery	47.52	10.23	27	108326	761	46576948
Asthenia	47.13	10.23	478	107875	310597	46267112
Disease progression	46.64	10.23	88	108265	91212	46486497
Anaemia	45.69	10.23	377	107976	255402	46322307
Platelet count decreased	45.52	10.23	103	108250	99921	46477788
Swollen tongue	45.16	10.23	160	108193	29072	46548637
Patient uncooperative	44.88	10.23	16	108337	141	46577568
Serotonin syndrome	44.00	10.23	140	108213	24080	46553629
Bradypnoea	43.61	10.23	44	108309	2995	46574714
Overdose	42.58	10.23	392	107961	101587	46476122
Red blood cell sedimentation rate	41.92	10.23	34	108319	1739	46575970
Oedema peripheral	41.46	10.23	210	108143	159496	46418213
Hospitalisation	41.08	10.23	52	108301	63333	46514376
Hypersensitivity	41.07	10.23	531	107822	149790	46427919
Abnormal weight gain	40.68	10.23	31	108322	1447	46576262
Therapeutic product effect decreased	40.48	10.23	329	108024	82272	46495437
Completed suicide	39.68	10.23	515	107838	145405	46432304
Blister	39.26	10.23	206	108147	44425	46533284
Gastric pH decreased	37.54	10.23	18	108335	354	46577355
Renal papillary necrosis	37.35	10.23	16	108337	239	46577470
Muscle injury	37.19	10.23	51	108302	4815	46572894
Pneumonia viral	37.09	10.23	60	108293	6564	46571145
C-reactive protein increased	37.07	10.23	248	108105	58342	46519367
Labile blood pressure	36.81	10.23	31	108322	1672	46576037
Derealisation	36.66	10.23	23	108330	780	46576929
Confusional state	36.47	10.23	547	107806	159345	46418364
Mental status changes	35.82	10.23	22	108331	38066	46539643
Pancreatic fibrosis	35.82	10.23	12	108341	86	46577623
Injection site swelling	35.61	10.23	25	108328	40302	46537407
White blood cell count decreased	35.52	10.23	137	108216	112094	46465615
Treatment failure	34.99	10.23	350	108003	92737	46484972
Toxicologic test abnormal	34.40	10.23	21	108332	678	46577031
Respiratory depression	34.06	10.23	80	108273	11520	46566189
Arthralgia	33.99	10.23	1096	107257	363507	46214202
Arteriosclerosis coronary artery	32.90	10.23	64	108289	8092	46569617
Renal failure	32.62	10.23	144	108209	113450	46464259
Precancerous cells present	32.52	10.23	25	108328	1182	46576527
Haematocrit decreased	31.94	10.23	21	108332	35036	46542673
Hallucination	31.94	10.23	212	108141	49739	46527970
Depersonalisation/derealisation disorder	31.87	10.23	23	108330	987	46576722
Febrile neutropenia	31.58	10.23	113	108240	94514	46483195
Blood pressure systolic increased	31.15	10.23	141	108212	28646	46549063
Necrosis ischaemic	30.75	10.23	21	108332	824	46576885
Anti-cyclic citrullinated peptide antibody positive	30.61	10.23	106	108247	19039	46558670
Pericarditis	30.37	10.23	123	108230	23804	46553905
Sepsis	30.32	10.23	188	108165	135826	46441883
Arthropathy	30.17	10.23	315	108038	84385	46493324
Device related thrombosis	30.01	10.23	24	108329	1203	46576506
C-reactive protein abnormal	29.96	10.23	113	108240	21157	46556552
Tongue disorder	29.60	10.23	57	108296	7153	46570556
Pituitary tumour benign	29.14	10.23	27	108326	1654	46576055
Needle issue	29.05	10.23	50	108303	5754	46571955
Neutropenia	28.86	10.23	204	108149	143000	46434709
Haemoglobin decreased	28.86	10.23	178	108175	128771	46448938
Duodenal ulcer perforation	28.72	10.23	62	108291	8440	46569269
Sleep disorder due to general medical condition, insomnia type	28.65	10.23	47	108306	5202	46572507
Blood pressure systolic decreased	28.19	10.23	47	108306	5271	46572438
Dehydration	28.06	10.23	236	108117	159304	46418405
Oral pain	27.99	10.23	123	108230	24674	46553035
Drug use disorder	27.75	10.23	33	108320	2702	46575007
General physical health deterioration	26.85	10.23	158	108195	115611	46462098
Opiates positive	26.82	10.23	13	108340	262	46577447
Deep vein thrombosis	26.79	10.23	95	108258	79678	46498031
Respiratory failure	26.73	10.23	121	108232	94695	46483014
Folliculitis	26.65	10.23	50	108303	6153	46571556
Finger deformity	26.54	10.23	45	108308	5117	46572592
Visceral congestion	25.79	10.23	13	108340	286	46577423
Small cell carcinoma	25.46	10.23	11	108342	168	46577541
Blood glucose increased	25.38	10.23	84	108269	71929	46505780
Pulmonary hypertension	24.94	10.23	28	108325	35965	46541744
Chronic obstructive pulmonary disease	24.89	10.23	61	108292	57572	46520137
Accidental exposure to product	24.70	10.23	9	108344	21072	46556637
Withdrawal syndrome	24.44	10.23	95	108258	18039	46559670
Injection site pruritus	24.32	10.23	34	108319	39709	46538000
H1N1 influenza	24.12	10.23	23	108330	1461	46576248
Retroperitoneal fibrosis	24.11	10.23	13	108340	330	46577379
Distributive shock	23.98	10.23	15	108338	506	46577203
Computerised tomogram thorax abnormal	23.86	10.23	22	108331	1339	46576370
Visual impairment	23.74	10.23	248	108105	66441	46511268
Blood creatinine increased	23.70	10.23	94	108259	76309	46501400
Coma	23.19	10.23	222	108131	58127	46519582
Diaphragmatic rupture	23	10.23	11	108342	215	46577494
Cerebrovascular accident	22.85	10.23	139	108214	100900	46476809
Product quality issue	22.31	10.23	30	108323	35618	46542091
Cardiomyopathy	22.26	10.23	5	108348	16068	46561641
Swelling face	22.15	10.23	204	108149	52855	46524854
Atrial fibrillation	22.14	10.23	145	108208	103445	46474264
Pain	22.08	10.23	1334	107019	475614	46102095
Muscle relaxant therapy	21.93	10.23	9	108344	120	46577589
Tendonitis	21.92	10.23	78	108275	14199	46563510
Blood potassium decreased	21.89	10.23	34	108319	38029	46539680
Metastases to eye	21.73	10.23	9	108344	123	46577586
Plasma cell myeloma	21.72	10.23	44	108309	44434	46533275
Pneumonia streptococcal	21.55	10.23	23	108330	1672	46576037
Accidental overdose	21.49	10.23	98	108255	19968	46557741
Septic shock	21.47	10.23	66	108287	57827	46519882
Helicobacter infection	21.46	10.23	68	108285	11668	46566041
Loss of employment	21.43	10.23	20	108333	1236	46576473
Laryngeal dyspnoea	21.41	10.23	9	108344	128	46577581
Fear of eating	21.13	10.23	12	108341	338	46577371
Hand deformity	21.06	10.23	145	108208	34429	46543280
Product use issue	20.87	10.23	322	108031	94322	46483387
Fall	20.84	10.23	593	107760	328504	46249205
Depression	20.79	10.23	274	108079	169830	46407879
Hyperhidrosis	20.52	10.23	306	108047	89002	46488707
Stomatitis	20.23	10.23	245	108108	68052	46509657
Duodenal ulcer repair	20.23	10.23	7	108346	56	46577653
Thrombocytopenia	20.16	10.23	192	108161	126389	46451320
Treatment noncompliance	19.67	10.23	24	108329	29707	46548002
Coronary artery disease	19.55	10.23	30	108323	33722	46543987
Device issue	19.55	10.23	11	108342	19969	46557740
Alanine aminotransferase increased	19.52	10.23	301	108052	88150	46489559
Neutropenic sepsis	19.50	10.23	68	108285	12256	46565453
Derailment	19.41	10.23	7	108346	64	46577645
Fibromyalgia	19.37	10.23	148	108205	36315	46541394
Protein C increased	19.29	10.23	9	108344	166	46577543
No adverse event	19.28	10.23	31	108322	34200	46543509
Hepatic infiltration eosinophilic	19.26	10.23	6	108347	33	46577676
Thiopurine methyltransferase decreased	19.20	10.23	11	108342	315	46577394
Feeling of body temperature change	19.18	10.23	35	108318	4217	46573492
Postmortem blood drug level abnormal	19.14	10.23	11	108342	317	46577392
Dependence	19.10	10.23	23	108330	1908	46575801
Mitral valve incompetence	19.00	10.23	10	108343	18842	46558867
Mouth swelling	18.75	10.23	32	108321	3657	46574052
Emergency care examination abnormal	18.70	10.23	5	108348	14	46577695
Soft tissue swelling	18.70	10.23	16	108337	882	46576827
Body temperature decreased	18.69	10.23	71	108282	13338	46564371
Cogwheel rigidity	18.56	10.23	20	108333	1470	46576239
Blood urea increased	18.37	10.23	19	108334	25333	46552376
Vomiting	18.31	10.23	1252	107101	451542	46126167
Cholelithiasis	18.27	10.23	39	108314	38642	46539067
Abdominal pain	18.24	10.23	679	107674	229352	46348357
Red blood cell count decreased	17.95	10.23	30	108323	32593	46545116
Drug resistance	17.82	10.23	9	108344	17359	46560350
Blood cholesterol increased	17.80	10.23	156	108197	39857	46537852
Gastrointestinal stoma complication	17.79	10.23	20	108333	1541	46576168
Fatigue	17.76	10.23	1196	107157	607501	45970208
Acute respiratory failure	17.76	10.23	25	108328	29113	46548596
Unevaluable event	17.58	10.23	52	108301	46123	46531586
Pericardial effusion	17.56	10.23	20	108333	25523	46552186
Transient ischaemic attack	17.50	10.23	34	108319	34869	46542840
Gastrooesophageal reflux disease	17.48	10.23	101	108252	74243	46503466
Intestinal fibrosis	17.43	10.23	8	108345	142	46577567
Change of bowel habit	17.39	10.23	21	108332	1747	46575962
Pulmonary function test abnormal	17.23	10.23	18	108335	1277	46576432
Diabetes mellitus	17.22	10.23	59	108294	50006	46527703
Skin lesion	17.21	10.23	22	108331	26691	46551018
Swelling	17.17	10.23	394	107959	124117	46453592
Chronic kidney disease	17.07	10.23	44	108309	40827	46536882
Hepatic ischaemia	17.07	10.23	12	108341	494	46577215
Oesophageal pain	16.99	10.23	25	108328	2518	46575191
Renal impairment	16.97	10.23	102	108251	74270	46503439
Premature labour	16.73	10.23	61	108292	11238	46566471
Procedural anxiety	16.65	10.23	12	108341	514	46577195
Premature delivery	16.61	10.23	16	108337	22053	46555656
Urinary tract infection	16.56	10.23	387	107966	219879	46357830
Dissociation	16.39	10.23	21	108332	1856	46575853
Tendon operation	16.38	10.23	10	108343	323	46577386
Multiple sclerosis relapse	16.35	10.23	47	108306	42078	46535631
Fluid retention	16.34	10.23	62	108291	50984	46526725
Intentional overdose	16.30	10.23	226	108127	64718	46512991
Beta haemolytic streptococcal infection	16.28	10.23	21	108332	1868	46575841
Gait disturbance	16.28	10.23	447	107906	144816	46432893
Foetal exposure during pregnancy	16.26	10.23	29	108324	30718	46546991
Cardiac failure	16.04	10.23	114	108239	79834	46497875
Injection site urticaria	16.03	10.23	4	108349	11963	46565746
Wheezing	16.02	10.23	192	108161	53194	46524515
White blood cell count increased	15.98	10.23	51	108302	44168	46533541
Injection site warmth	15.93	10.23	6	108347	13766	46563943
Oedema	15.83	10.23	91	108262	66980	46510729
Osteonecrosis	15.78	10.23	22	108331	25722	46551987
Sensitisation	15.71	10.23	13	108340	684	46577025
Hypersensitivity vasculitis	15.68	10.23	32	108321	4189	46573520
Benzodiazepine drug level increased	15.63	10.23	8	108345	182	46577527
Urticaria	15.62	10.23	371	107982	117521	46460188
Induced abortion failed	15.61	10.23	9	108344	261	46577448
Thrombosis	15.53	10.23	72	108281	55997	46521712
Myocardial fibrosis	15.53	10.23	12	108341	572	46577137
Pain in jaw	15.50	10.23	42	108311	38330	46539379
Feeling of despair	15.46	10.23	20	108333	1785	46575924
Injection site reaction	15.39	10.23	58	108295	47791	46529918
Dermatitis allergic	15.37	10.23	64	108289	12539	46565170
Pleural effusion	15.35	10.23	121	108232	82831	46494878
Hallucinations, mixed	15.28	10.23	30	108323	3819	46573890
Hot flush	15.16	10.23	51	108302	43466	46534243
Device dislocation	15.06	10.23	17	108336	21785	46555924
Costovertebral angle tenderness	15.04	10.23	6	108347	74	46577635
Drug detoxification	15.02	10.23	8	108345	198	46577511
Dysmetropsia	14.97	10.23	6	108347	75	46577634
Maternal exposure during pregnancy	14.90	10.23	159	108194	102390	46475319
Myelodysplastic syndrome	14.88	10.23	9	108344	15702	46562007
Ileus	14.87	10.23	7	108346	14057	46563652
Ascites	14.81	10.23	40	108313	36544	46541165
Alveolar rhabdomyosarcoma	14.79	10.23	5	108348	37	46577672
Blood count abnormal	14.61	10.23	12	108341	17866	46559843
Agranulocytosis	14.58	10.23	18	108335	22167	46555542
Peritonitis	14.48	10.23	16	108337	20698	46557011
Limb operation	14.46	10.23	27	108326	3311	46574398
Neuropathy peripheral	14.41	10.23	138	108215	90755	46486954
Weight decreased	14.34	10.23	376	107977	210473	46367236
Mite allergy	14.24	10.23	10	108343	411	46577298
Therapy cessation	14.18	10.23	25	108328	26604	46551105
Stubbornness	14.10	10.23	8	108345	225	46577484
Fluid overload	14.05	10.23	26	108327	27159	46550550
Lethargy	14.05	10.23	181	108172	50990	46526719
Intestinal strangulation	13.98	10.23	6	108347	90	46577619
Device related infection	13.90	10.23	17	108336	21024	46556685
Uveal melanoma	13.87	10.23	4	108349	16	46577693
Blood triglycerides increased	13.85	10.23	5	108348	11778	46565931
Infective pulmonary exacerbation of cystic fibrosis	13.74	10.23	4	108349	10803	46566906
Bacteraemia	13.60	10.23	8	108345	14171	46563538
Carcinoid crisis	13.57	10.23	8	108345	242	46577467
Toxic shock syndrome streptococcal	13.41	10.23	6	108347	100	46577609
Cerebral infarction	13.31	10.23	21	108332	23345	46554364
Respiratory rate decreased	13.28	10.23	25	108328	3085	46574624
Fear-related avoidance of activities	13.25	10.23	6	108347	103	46577606
Sphincter of Oddi dysfunction	13.23	10.23	9	108344	351	46577358
Tuberculosis	13.21	10.23	53	108300	10212	46567497
Disease recurrence	13.21	10.23	14	108339	18457	46559252
Limb mass	13.16	10.23	22	108331	2472	46575237
Red blood cell nucleated morphology present	13.15	10.23	4	108349	20	46577689
Vaccination site joint pain	13.13	10.23	3	108350	3	46577706
Irritable bowel syndrome	13.02	10.23	74	108279	16441	46561268
Cholangiectasis acquired	12.99	10.23	4	108349	21	46577688
Injection site bruising	12.94	10.23	41	108312	35595	46542114
Fungal infection	12.94	10.23	31	108322	29489	46548220
Respiratory distress	12.84	10.23	35	108318	31881	46545828
Lymphopenia	12.83	10.23	10	108343	15283	46562426
Product complaint	12.83	10.23	6	108347	12095	46565614
Parosmia	12.76	10.23	29	108324	4087	46573622
Pubic pain	12.73	10.23	5	108348	59	46577650
Abortion induced	12.68	10.23	4	108349	10256	46567453
Anterograde amnesia	12.66	10.23	9	108344	377	46577332
Off label use	12.66	10.23	737	107616	379104	46198605
Seizure	12.65	10.23	205	108148	122849	46454860
Premature baby	12.65	10.23	14	108339	18098	46559611
Caesarean section	12.54	10.23	12	108341	16591	46561118
Hypotension	12.53	10.23	428	107925	232161	46345548
Gallbladder cholesterolosis	12.50	10.23	12	108341	769	46576940
Urine output decreased	12.49	10.23	55	108298	11042	46566667
Cholesteatoma	12.47	10.23	6	108347	119	46577590
Oral contusion	12.44	10.23	5	108348	63	46577646
Infrequent bowel movements	12.30	10.23	14	108339	1094	46576615
COVID-19	12.28	10.23	15	108338	18560	46559149
Adverse drug reaction	12.27	10.23	57	108296	44305	46533404
Exposure during pregnancy	12.24	10.23	177	108176	108035	46469674
Anxiety	12.23	10.23	325	108028	181632	46396077
Ill-defined disorder	12.14	10.23	105	108248	26722	46550987
Shock	12.10	10.23	20	108333	21825	46555884
Influenza like illness	12.09	10.23	81	108272	57489	46520220
Escherichia infection	12.04	10.23	5	108348	10812	46566897
Hyperprolinaemia	12.02	10.23	4	108349	28	46577681
Jaw clicking	12.02	10.23	4	108349	28	46577681
Lung infiltration	12.01	10.23	9	108344	14034	46563675
Bulimia nervosa	11.94	10.23	10	108343	535	46577174
Haemophilus test positive	11.92	10.23	3	108350	6	46577703
Ataxia	11.82	10.23	9	108344	13921	46563788
Musculoskeletal disorder	11.82	10.23	69	108284	15476	46562233
Pyroglutamate increased	11.81	10.23	9	108344	420	46577289
Antisocial behaviour	11.81	10.23	7	108346	214	46577495
Acute interstitial pneumonitis	11.80	10.23	11	108342	679	46577030
Multiple sclerosis	11.70	10.23	25	108328	24766	46552943
Suspected counterfeit product	11.65	10.23	8	108345	317	46577392
Hernia	11.64	10.23	49	108304	9646	46568063
Duodenal ulcer	11.57	10.23	40	108313	7178	46570531
External ear disorder	11.56	10.23	4	108349	32	46577677
Cranial sutures widening	11.56	10.23	4	108349	32	46577677
Acute chest syndrome	11.55	10.23	10	108343	560	46577149
Pneumocystis jirovecii pneumonia	11.54	10.23	11	108342	15237	46562472
Drug diversion	11.51	10.23	12	108341	849	46576860
Meningorrhagia	11.47	10.23	6	108347	143	46577566
Neurotoxicity	11.47	10.23	9	108344	13708	46564001
Progressive multifocal leukoencephalopathy	11.46	10.23	6	108347	11340	46566369
Strabismus congenital	11.45	10.23	4	108349	33	46577676
Cholecystitis chronic	11.45	10.23	5	108348	10494	46567215
Deformity	11.44	10.23	40	108313	7217	46570492
Peritonitis bacterial	11.38	10.23	3	108350	8650	46569059
Lip infection	11.36	10.23	5	108348	80	46577629
Electrolyte imbalance	11.29	10.23	14	108339	17212	46560497
Sacroiliitis	11.27	10.23	19	108334	2150	46575559
Acute myeloid leukaemia	11.23	10.23	12	108341	15766	46561943
Eosinophilia	11.21	10.23	17	108336	19200	46558509
Hyperlipidaemia	11.20	10.23	16	108337	18523	46559186
Blood loss anaemia	11.19	10.23	3	108350	8554	46569155
Muscular weakness	11.18	10.23	148	108205	91696	46486013
Dermal sinus	11.05	10.23	4	108349	37	46577672
Device malfunction	10.90	10.23	9	108344	13365	46564344
Agitation	10.89	10.23	185	108168	55230	46522479
Cafe au lait spots	10.86	10.23	4	108349	39	46577670
Neoplasm malignant	10.84	10.23	24	108329	23475	46554234
Schizophrenia	10.83	10.23	44	108309	8524	46569185
Intestinal ulcer perforation	10.83	10.23	3	108350	10	46577699
Haemophagocytic lymphohistiocytosis	10.77	10.23	3	108350	8339	46569370
Libido increased	10.75	10.23	11	108342	761	46576948
Underdose	10.75	10.23	18	108335	19540	46558169
Therapy non-responder	10.72	10.23	54	108299	41098	46536611
Product prescribing issue	10.72	10.23	12	108341	920	46576789
Abnormal palmar/plantar creases	10.60	10.23	4	108349	42	46577667
Periorbital cellulitis	10.60	10.23	9	108344	491	46577218
Sinusitis	10.59	10.23	225	108128	129543	46448166
Restless legs syndrome	10.58	10.23	68	108285	15775	46561934
Pancreatitis acute	10.56	10.23	96	108257	24776	46552933
Staphylococcal infection	10.47	10.23	45	108308	35726	46541983
Thyroid adenoma	10.44	10.23	6	108347	173	46577536
Alanine aminotransferase abnormal	10.40	10.23	20	108333	2507	46575202
Naevus haemorrhage	10.35	10.23	5	108348	100	46577609
Hyperglycaemia	10.34	10.23	44	108309	35027	46542682
Lactic acidosis	10.33	10.23	42	108311	33867	46543842
Emphysema	10.28	10.23	45	108308	9009	46568700
Urinary retention	10.27	10.23	99	108254	25962	46551747
Tricuspid valve incompetence	10.26	10.23	10	108343	13707	46564002
Injection site induration	10.25	10.23	3	108350	8076	46569633

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	1550.61	10.57	1164	45312	80908	29825094
Toxicity to various agents	1322.62	10.57	1492	44984	175691	29730311
Drug hypersensitivity	420.02	10.57	524	45952	67995	29838007
Substance abuse	241.06	10.57	145	46331	6895	29899107
Prescription form tampering	228.21	10.57	68	46408	502	29905500
Overdose	218.18	10.57	434	46042	83903	29822099
Drug dependence	165.24	10.57	184	46292	21111	29884891
Intentional product misuse	155.40	10.57	228	46248	34439	29871563
Intentional overdose	92.45	10.57	201	46275	41280	29864722
Poisoning	84.25	10.57	96	46380	11286	29894716
Poisoning deliberate	75.51	10.57	67	46409	5837	29900165
Drug ineffective	71.78	10.57	279	46197	340108	29565894
Completed suicide	71.63	10.57	325	46151	99167	29806835
Lower respiratory tract infection	65.95	10.57	135	46341	26579	29879423
Asphyxia	58.56	10.57	56	46420	5369	29900633
Depressed level of consciousness	50.45	10.57	152	46324	38070	29867932
Drug use disorder	50.00	10.57	41	46435	3207	29902795
Miosis	43.59	10.57	57	46419	7719	29898283
Respiratory depression	43.54	10.57	70	46406	11433	29894569
Duodenal ulcer perforation	40.91	10.57	28	46448	1664	29904338
Somnolence	38.16	10.57	269	46207	96494	29809508
Myocardial infarction	33.96	10.57	92	46384	125533	29780469
Nightmare	33.37	10.57	64	46412	12012	29893990
Malaise	32.60	10.57	399	46077	166563	29739439
Off label use	32.02	10.57	241	46235	249049	29656953
Bradypnoea	31.15	10.57	25	46451	1896	29904106
Respiratory arrest	31.04	10.57	108	46368	29150	29876852
Poor feeding infant	30.90	10.57	14	46462	367	29905635
Prescription drug used without a prescription	30.79	10.57	21	46455	1241	29904761
Analgesic drug level increased	30.72	10.57	16	46460	573	29905429
Pseudoporphyria	28.77	10.57	12	46464	256	29905746
Peripheral circulatory failure	27.94	10.57	11	46465	201	29905801
Coma scale abnormal	27.60	10.57	30	46446	3346	29902656
Neutropenic sepsis	27.37	10.57	57	46419	11352	29894650
Chronic gastrointestinal bleeding	25.81	10.57	11	46465	248	29905754
Chemical poisoning	25.66	10.57	9	46467	117	29905885
Anaemia	24.85	10.57	205	46271	207787	29698215
Perineal pain	24.77	10.57	14	46462	591	29905411
Multiple organ dysfunction syndrome	24.35	10.57	38	46438	63449	29842553
Cytomegalovirus infection	23.88	10.57	4	46472	23670	29882332
Calcium deficiency	23.67	10.57	9	46467	149	29905853
Pulmonary congestion	23.42	10.57	56	46420	12231	29893771
Pulmonary oedema	23.38	10.57	132	46344	43843	29862159
Agitated depression	23.24	10.57	10	46466	231	29905771
Mouth ulceration	23.15	10.57	51	46425	10558	29895444
Sepsis	23.06	10.57	133	46343	146262	29759740
Spinal cord infection	23.03	10.57	9	46467	161	29905841
Cardiac failure congestive	22.66	10.57	62	46414	84345	29821657
Drug interaction	22.33	10.57	434	46042	199134	29706868
Anal ulcer	22.27	10.57	13	46463	584	29905418
Mouth swelling	22.16	10.57	19	46457	1580	29904422
Product dose omission issue	21.93	10.57	71	46405	91560	29814442
Otospondylomegaepiphyseal dysplasia	21.53	10.57	8	46468	124	29905878
Febrile neutropenia	21.38	10.57	89	46387	106604	29799398
Drug resistance	21.22	10.57	3	46473	20130	29885872
Lip swelling	21.05	10.57	55	46421	12689	29893313
Liver function test abnormal	20.67	10.57	99	46377	30851	29875151
Weight decrease neonatal	20.03	10.57	10	46466	327	29905675
Nervous system neoplasm	19.93	10.57	8	46468	154	29905848
Analgesic drug level above therapeutic	19.86	10.57	9	46467	236	29905766
Swelling face	19.72	10.57	75	46401	21129	29884873
Cardio-respiratory arrest	19.55	10.57	154	46322	57152	29848850
Pyrexia	19.39	10.57	331	46145	294158	29611844
Orthostatic hypotension	19.24	10.57	81	46395	23898	29882104
Alice in wonderland syndrome	19.14	10.57	5	46471	21	29905981
Anal fissure	19.12	10.57	21	46455	2370	29903632
General physical health deterioration	19.02	10.57	85	46391	99859	29806143
Overgrowth bacterial	18.92	10.57	7	46469	107	29905895
Renal failure	18.82	10.57	120	46356	128846	29777156
Morganella infection	18.78	10.57	10	46466	375	29905627
Ulcer	18.77	10.57	36	46440	6755	29899247
Arteriosclerosis coronary artery	18.22	10.57	48	46428	11128	29894874
Accidental overdose	18.13	10.57	66	46410	18209	29887793
Gangrene neonatal	17.79	10.57	8	46468	206	29905796
Disease progression	17.68	10.57	64	46412	79810	29826192
Osmolar gap abnormal	17.01	10.57	5	46471	35	29905967
Genitalia external ambiguous	16.85	10.57	8	46468	234	29905768
Phlebosclerosis	16.84	10.57	7	46469	148	29905854
Exposure via breast milk	16.54	10.57	16	46460	1556	29904446
Blood pressure fluctuation	16.35	10.57	62	46414	17441	29888561
Linear IgA disease	16.28	10.57	16	46460	1586	29904416
Vomiting	16.20	10.57	451	46025	219367	29686635
Withdrawal syndrome	16.04	10.57	46	46430	11204	29894798
Idiopathic pulmonary fibrosis	15.72	10.57	25	46451	4044	29901958
Rhinalgia	15.71	10.57	9	46467	390	29905612
Gastrointestinal mucosa hyperaemia	15.50	10.57	7	46469	182	29905820
Inferior vena cava dilatation	15.19	10.57	7	46469	191	29905811
Bronchial haemorrhage	15.15	10.57	11	46465	718	29905284
Sleep deficit	15.14	10.57	9	46467	418	29905584
Secondary hypogonadism	15.09	10.57	8	46468	297	29905705
Congenital bladder anomaly	15.07	10.57	8	46468	298	29905704
Product use in unapproved indication	15.05	10.57	61	46415	73632	29832370
Skin turgor decreased	15.05	10.57	9	46467	423	29905579
Moaning	14.81	10.57	11	46465	744	29905258
Overlap syndrome	14.77	10.57	5	46471	58	29905944
Increased bronchial secretion	14.61	10.57	14	46462	1345	29904657
Apparent life threatening event	14.52	10.57	7	46469	212	29905790
Maternal exposure during breast feeding	14.22	10.57	15	46461	1617	29904385
Anomaly of external ear congenital	14.17	10.57	6	46470	133	29905869
External auditory canal atresia	13.93	10.57	6	46470	139	29905863
Aspartate aminotransferase increased	13.91	10.57	51	46425	63371	29842631
Hospitalisation	13.90	10.57	30	46446	44289	29861713
Platelet count decreased	13.86	10.57	102	46374	106027	29799975
Patient dissatisfaction with treatment	13.85	10.57	5	46471	71	29905931
Accidental poisoning	13.77	10.57	9	46467	495	29905507
Palpitations	13.60	10.57	94	46382	33479	29872523
Foetal hypokinesia	13.51	10.57	8	46468	369	29905633
Gastrointestinal ulcer	13.48	10.57	15	46461	1717	29904285
Depression suicidal	13.45	10.57	13	46463	1263	29904739
Hyponatraemic seizure	13.42	10.57	5	46471	78	29905924
Crystalluria	13.39	10.57	8	46468	375	29905627
Suicide attempt	13.28	10.57	100	46376	36597	29869405
Depressed mood	13.26	10.57	57	46419	16972	29889030
Foaming at mouth	13.25	10.57	10	46466	693	29905309
Therapeutic response decreased	13.22	10.57	11	46465	24338	29881664
Delirium	13.20	10.57	108	46368	40523	29865479
Self-medication	13.14	10.57	17	46459	2277	29903725
Leukopenia	13.09	10.57	44	46432	56115	29849887
Adrenergic syndrome	13.03	10.57	5	46471	85	29905917
Confusional state	13.01	10.57	287	46189	134547	29771455
Treatment noncompliance	12.99	10.57	12	46464	25241	29880761
Coronary artery disease	12.97	10.57	37	46439	49675	29856327
Thrombocytopenia	12.96	10.57	143	46333	136901	29769101
Drug diversion	12.93	10.57	11	46465	905	29905097
Mucosal inflammation	12.92	10.57	17	46459	30477	29875525
Wrong patient received product	12.89	10.57	15	46461	1802	29904200
Injection site pain	12.74	10.57	17	46459	30293	29875709
Paratracheal lymphadenopathy	12.72	10.57	5	46471	91	29905911
Premature baby	12.68	10.57	5	46471	16686	29889316
Cluster headache	12.60	10.57	9	46467	573	29905429
Injection site erythema	12.57	10.57	3	46473	13831	29892171
Mental status changes	12.56	10.57	24	46452	37055	29868947
Clumsiness	12.53	10.57	13	46463	1374	29904628
Neonatal respiratory depression	12.49	10.57	8	46468	425	29905577
Pancytopenia	12.46	10.57	79	46397	84973	29821029
Hyporesponsive to stimuli	12.46	10.57	11	46465	951	29905051
Plasma cell myeloma	12.39	10.57	42	46434	53420	29852582
Intercepted product prescribing error	12.06	10.57	5	46471	105	29905897
Defaecation urgency	11.97	10.57	13	46463	1448	29904554
Skin fragility	11.97	10.57	8	46468	457	29905545
Peripheral artery thrombosis	11.95	10.57	16	46460	2216	29903786
Psychomotor skills impaired	11.86	10.57	15	46461	1964	29904038
Pouchitis	11.62	10.57	9	46467	648	29905354
Drug withdrawal syndrome neonatal	11.58	10.57	19	46457	3156	29902846
Asthenia	11.41	10.57	259	46217	221031	29684971
Atrial fibrillation	11.37	10.57	110	46366	108014	29797988
Medication overuse headache	11.34	10.57	4	46472	53	29905949
Haematocrit decreased	11.18	10.57	19	46457	30680	29875322
Male sexual dysfunction	11.03	10.57	6	46470	235	29905767
Therapy non-responder	10.94	10.57	18	46458	29435	29876567
Visceral congestion	10.84	10.57	8	46468	536	29905466
Ejection fraction decreased	10.80	10.57	5	46471	15170	29890832
Tendon discomfort	10.75	10.57	6	46470	247	29905755
Social problem	10.74	10.57	9	46467	725	29905277
Fat redistribution	10.73	10.57	5	46471	140	29905862
Tooth injury	10.58	10.57	9	46467	741	29905261

Pharmacologic Action:

Source	Code	Description
ATC	R05DA04	RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Opium alkaloids and derivatives
ATC	N02AA59	NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids
ATC	N02AA79	NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids
ATC	N02AJ06	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
ATC	N02AJ07	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
ATC	N02AJ08	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
ATC	N02AJ09	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
FDA MoA	N0000175684	Full Opioid Agonists
FDA EPC	N0000175690	Opioid Agonist
MeSH PA	D000700	Analgesics
MeSH PA	D000701	Analgesics, Opioid
MeSH PA	D000996	Antitussive Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D009294	Narcotics
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35482	narcotic analgesics
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:50266	prodrugs
CHEBI has role	CHEBI:51177	cough suppressant
CHEBI has role	CHEBI:60606	opioid receptor agonists
CHEBI has role	CHEBI:78298	environmental contaminants
CHEBI has role	CHEBI:88188	allergenic drug

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Pain	indication	22253000
Cough	indication	49727002
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Rhinitis	indication	70076002	DOID:4483
Sneezing	indication	76067001
Common cold	indication	82272006	DOID:10459
Headache disorder	indication	230461009
Sore throat symptom	indication	267102003
Influenza-like symptoms	indication	315642008
Fever	indication	386661006
Tension-type headache	indication	398057008
Muscle Spasm with Pain	indication
Diarrhea	off-label use	62315008
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Goiter	contraindication	3716002	DOID:12176
Ocular hypertension	contraindication	4210003	DOID:9282
Gastritis	contraindication	4556007	DOID:4029
Suicidal thoughts	contraindication	6471006
Dependent drug abuse	contraindication	6525002
Alcoholism	contraindication	7200002
Alcohol withdrawal delirium	contraindication	8635005
Hyperammonemia	contraindication	9360008
Peptic ulcer	contraindication	13200003	DOID:750
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Asthenia	contraindication	13791008
Hepatic encephalopathy	contraindication	13920009	DOID:13413
Hyperkalemia	contraindication	14140009
Constipation	contraindication	14760008	DOID:2089
Hyperbilirubinemia	contraindication	14783006	DOID:2741
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Chronic disease of respiratory system	contraindication	17097001
Mood swings	contraindication	18963009
Lowered convulsive threshold	contraindication	19260006
Hashimoto thyroiditis	contraindication	21983002
Myocardial infarction	contraindication	22298006	DOID:5844
Disorder of the central nervous system	contraindication	23853001	DOID:331
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Ventricular tachycardia	contraindication	25569003
Acute tuberculosis	contraindication	25629007
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Hypercapnia	contraindication	29596007
Bronchitis	contraindication	32398004	DOID:6132
Dehydration	contraindication	34095006
Hyperthyroidism	contraindication	34486009	DOID:7998
Depressive disorder	contraindication	35489007
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Gastrointestinal ulcer	contraindication	40845000
Hypothyroidism	contraindication	40930008	DOID:1459
Body fluid retention	contraindication	43498006
Hyperactive behavior	contraindication	44548000
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Acidosis	contraindication	51387008
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Blood coagulation disorder	contraindication	64779008	DOID:1247
Arterial thrombosis	contraindication	65198009
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Psychotic disorder	contraindication	69322001
Poisoning by acetaminophen	contraindication	70273001
Agoraphobia	contraindication	70691001	DOID:593
Arteriosclerotic vascular disease	contraindication	72092001
Sedation	contraindication	72641008
Hepatic coma	contraindication	72836002	DOID:12550
Diabetes mellitus	contraindication	73211009	DOID:9351
Sleep apnea	contraindication	73430006	DOID:0050847
Factor II deficiency	contraindication	73975000
Reye's syndrome	contraindication	74351001	DOID:14525
Gastrointestinal hemorrhage	contraindication	74474003
Urethral stricture	contraindication	76618002
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Decreased respiratory function	contraindication	80954004
Disorder of brain	contraindication	81308009	DOID:936
Injury of head	contraindication	82271004
Chronic idiopathic constipation	contraindication	82934008
Cor pulmonale	contraindication	83291003	DOID:8515
Epilepsy	contraindication	84757009	DOID:1826
Pulmonary emphysema	contraindication	87433001
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Thyrotoxicosis	contraindication	90739004	DOID:7997
Hemophilia	contraindication	90935002
Dermatitis herpetiformis	contraindication	111196000	DOID:8505
Anemia due to enzyme deficiency	contraindication	111577008
Acute abdominal pain	contraindication	116290004
Procedure on urinary system	contraindication	118677009
Gastrointestinal obstruction	contraindication	126765001
Neoplasm of brain	contraindication	126952004	DOID:1319
von Willebrand disorder	contraindication	128105004	DOID:12531
Seizure disorder	contraindication	128613002
Drug-induced psychosis	contraindication	191483003	DOID:1742
Obsessive-compulsive disorder	contraindication	191736004	DOID:10933
Insomnia	contraindication	193462001
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Acute intermittent porphyria	contraindication	234422006	DOID:3890
Gastroesophageal reflux disease	contraindication	235595009	DOID:8534
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Morbid obesity	contraindication	238136002	DOID:11981
Hypocomplementemic urticarial vasculitis	contraindication	239945009
Pyloric obstruction	contraindication	244815007
Sleep automatism	contraindication	247962006
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Anemia	contraindication	271737000	DOID:2355
Exacerbation of asthma	contraindication	281239006
Pregnancy, function	contraindication	289908002
Lesion of brain	contraindication	301766008
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Panic disorder	contraindication	371631005	DOID:594
Coma	contraindication	371632003
Primary adrenocortical insufficiency	contraindication	373662000
Operation on gastrointestinal tract	contraindication	386621005
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Cardiovascular event risk	contraindication	395112001
Pseudomembranous enterocolitis	contraindication	397683000
Respiratory insufficiency	contraindication	409623005
Breastfeeding (mother)	contraindication	413712001
Chronic myocardial ischemia	contraindication	413844008	DOID:3393
Disorder of coronary artery	contraindication	414024009
Myocardial ischemia	contraindication	414795007	DOID:3393
Myocardial infarction in recovery phase	contraindication	418044006
Central nervous system depression	contraindication	418072004
Porphyria	contraindication	418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	422681000
Poor metabolizer due to cytochrome p450 CYP2C19 variant	contraindication	424500005
Dysfunction of sphincter of Oddi	contraindication	430887001
Hypertensive urgency	contraindication	443482000
Acute erosive gastritis	contraindication	444926003
Acute exacerbation of asthma	contraindication	708038006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.38	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN	AGONIST	Ki	6.14	CHEMBL	CHEMBL
Kappa-type opioid receptor	GPCR	P41145	OPRK_HUMAN	AGONIST	Ki	4.59	CHEMBL
Delta-type opioid receptor	GPCR	P41143	OPRD_HUMAN	AGONIST	Ki	4.28	CHEMBL
Opioid receptor	GPCR		OPRD_RAT OPRK_RAT OPRM_RAT SGMR1_RAT		IC50	8	CHEMBL

External reference:

ID	Source
4017509	VUID
N0000145894	NUI
D00195	KEGG_DRUG
6059-47-8	SECONDARY_CAS_RN
4017414	VANDF
4017415	VANDF
4017509	VANDF
4019491	VANDF
C0009214	UMLSCUI
CHEBI:16714	CHEBI
5284371	PUBCHEM_CID
CHEMBL485	ChEMBL_ID
CHEMBL369475	ChEMBL_ID
CHEMBL1201099	ChEMBL_ID
CHEMBL1159819	ChEMBL_ID
CHEMBL1201463	ChEMBL_ID
CHEMBL284671	ChEMBL_ID
CHEMBL4297091	ChEMBL_ID
DB00318	DRUGBANK_ID
D003061	MESH_DESCRIPTOR_UI
1673	IUPHAR_LIGAND_ID
Q830PW7520	UNII
1545976	RXNORM
32159	MMSL
4490	MMSL
4491	MMSL
4492	MMSL
4675	MMSL
4676	MMSL
d00012	MMSL
001550	NDDF
001551	NDDF
001552	NDDF
001553	NDDF
005189	NDDF
1476002	SNOMEDCT_US
261000	SNOMEDCT_US
387494007	SNOMEDCT_US
85990009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Fiorinal with Codeine	HUMAN PRESCRIPTION DRUG LABEL	4	0023-6010	CAPSULE	30 mg	ORAL	NDA	36 sections
Codeine sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0243	TABLET	15 mg	ORAL	NDA	32 sections
Codeine sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0244	TABLET	30 mg	ORAL	NDA	32 sections
Codeine sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0245	TABLET	60 mg	ORAL	NDA	32 sections
Acetaminophen and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	2	0093-0050	TABLET	15 mg	ORAL	ANDA	27 sections
Acetaminophen and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	2	0093-0150	TABLET	30 mg	ORAL	ANDA	27 sections
Acetaminophen and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	2	0093-0350	TABLET	60 mg	ORAL	ANDA	27 sections
Acetaminophen and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	2	0121-0504	SOLUTION	12 mg	ORAL	ANDA	34 sections
PROMETHAZINE HYDROCHLORIDE AND CODEINE PHOSPHATE	HUMAN PRESCRIPTION DRUG LABEL	2	0121-0547	SYRUP	10 mg	ORAL	ANDA	30 sections
Guaifenesin and Codeine Phosphate	HUMAN OTC DRUG LABEL	2	0121-0775	SOLUTION	10 mg	ORAL	OTC monograph final	16 sections
Promethazine VC with Codeine Oral Solution	HUMAN PRESCRIPTION DRUG LABEL	3	0121-0925	SOLUTION	10 mg	ORAL	ANDA	29 sections
Promethazine with Codeine	HUMAN PRESCRIPTION DRUG LABEL	2	0121-0928	SOLUTION	10 mg	ORAL	ANDA	29 sections
Acetaminophen and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	2	0121-1008	SOLUTION	30 mg	ORAL	ANDA	34 sections
Guaifenesin and Codeine Phosphate	HUMAN OTC DRUG LABEL	2	0121-1550	SOLUTION	10 mg	ORAL	OTC monograph final	16 sections
Guaifenesin and Codeine Phosphate	HUMAN OTC DRUG LABEL	2	0121-1775	SOLUTION	10 mg	ORAL	OTC monograph final	16 sections
ACETAMINOPHEN AND CODEINE PHOSPHATE	HUMAN PRESCRIPTION DRUG LABEL	2	0406-0483	TABLET	15 mg	ORAL	ANDA	15 sections
ACETAMINOPHEN AND CODEINE PHOSPHATE	HUMAN PRESCRIPTION DRUG LABEL	2	0406-0484	TABLET	30 mg	ORAL	ANDA	15 sections
ACETAMINOPHEN AND CODEINE PHOSPHATE	HUMAN PRESCRIPTION DRUG LABEL	2	0406-0485	TABLET	60 mg	ORAL	ANDA	15 sections
Acetaminophen And Codeine	HUMAN PRESCRIPTION DRUG LABEL	2	0440-7026	TABLET	30 mg	ORAL	ANDA	31 sections
Acetaminophen And Codeine	HUMAN PRESCRIPTION DRUG LABEL	2	0440-7027	TABLET	60 mg	ORAL	ANDA	31 sections
Butalbital, Aspirin, Caffeine and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	4	0527-1312	CAPSULE	30 mg	ORAL	ANDA	25 sections
Codeine Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0527-1698	TABLET	30 mg	ORAL	ANDA	32 sections
Codeine Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0527-1699	TABLET	60 mg	ORAL	ANDA	32 sections
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	4	0591-2641	CAPSULE	30 mg	ORAL	ANDA	27 sections
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	4	0591-3220	CAPSULE	30 mg	ORAL	NDA AUTHORIZED GENERIC	32 sections
Butalbital, Aspirin, Caffeine and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	4	0591-3546	CAPSULE	30 mg	ORAL	NDA authorized generic	36 sections
Acetaminophen And Codeine	HUMAN PRESCRIPTION DRUG LABEL	2	0603-2337	TABLET	15 mg	ORAL	ANDA	34 sections
Acetaminophen And Codeine	HUMAN PRESCRIPTION DRUG LABEL	2	0603-2338	TABLET	30 mg	ORAL	ANDA	34 sections
Acetaminophen And Codeine	HUMAN PRESCRIPTION DRUG LABEL	2	0603-2339	TABLET	60 mg	ORAL	ANDA	34 sections
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate	HUMAN PRESCRIPTION DRUG LABEL	4	0603-2553	CAPSULE	30 mg	ORAL	ANDA	35 sections