Stem definition | Drug id | CAS RN |
---|---|---|
725 | 76-57-3 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 435 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.10 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 20.04 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3.50 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 15 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.70 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 4 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 21, 1952 | FDA | ANI PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 4657.98 | 10.23 | 4107 | 104246 | 239718 | 46337991 |
Toxicity to various agents | 372.21 | 10.23 | 1208 | 107145 | 210558 | 46367151 |
Blood parathyroid hormone decreased | 277.52 | 10.23 | 155 | 108198 | 4226 | 46573483 |
Granuloma skin | 253.72 | 10.23 | 135 | 108218 | 3335 | 46574374 |
Panniculitis | 247.09 | 10.23 | 158 | 108195 | 5546 | 46572163 |
Drug abuse | 230.43 | 10.23 | 476 | 107877 | 62932 | 46514777 |
Contrast media allergy | 199.83 | 10.23 | 93 | 108260 | 1706 | 46576003 |
Skin necrosis | 178.60 | 10.23 | 153 | 108200 | 8451 | 46569258 |
Rheumatoid nodule | 178.34 | 10.23 | 156 | 108197 | 8864 | 46568845 |
Drug intolerance | 162.47 | 10.23 | 724 | 107629 | 146325 | 46431384 |
Rheumatoid arthritis | 158.33 | 10.23 | 1026 | 107327 | 239189 | 46338520 |
Tenosynovitis | 138.68 | 10.23 | 125 | 108228 | 7390 | 46570319 |
Ulcer | 137.11 | 10.23 | 185 | 108168 | 17207 | 46560502 |
Peripheral swelling | 129.54 | 10.23 | 715 | 107638 | 157356 | 46420353 |
Basal cell carcinoma | 126.43 | 10.23 | 194 | 108159 | 20293 | 46557416 |
Contraindicated product administered | 124.04 | 10.23 | 438 | 107915 | 79509 | 46498200 |
Drug dependence | 111.11 | 10.23 | 180 | 108173 | 19721 | 46557988 |
Hypercalcaemia | 108.97 | 10.23 | 184 | 108169 | 20862 | 46556847 |
Lower respiratory tract infection | 104.37 | 10.23 | 323 | 108030 | 54766 | 46522943 |
Enthesopathy | 100.61 | 10.23 | 85 | 108268 | 4605 | 46573104 |
Skin ulcer | 97.73 | 10.23 | 226 | 108127 | 32232 | 46545477 |
Soft tissue disorder | 94.21 | 10.23 | 78 | 108275 | 4108 | 46573601 |
Joint swelling | 93.60 | 10.23 | 683 | 107670 | 165390 | 46412319 |
Drug tolerance decreased | 92.76 | 10.23 | 68 | 108285 | 2991 | 46574718 |
Loss of personal independence in daily activities | 92.76 | 10.23 | 318 | 108035 | 56865 | 46520844 |
Rash | 91.09 | 10.23 | 1243 | 107110 | 355269 | 46222440 |
Drug eruption | 88.08 | 10.23 | 169 | 108184 | 21160 | 46556549 |
Substance abuse | 84.25 | 10.23 | 73 | 108280 | 4094 | 46573615 |
Infusion related reaction | 82.28 | 10.23 | 457 | 107896 | 100751 | 46476958 |
Poisoning deliberate | 79.39 | 10.23 | 95 | 108258 | 7831 | 46569878 |
Rash pruritic | 77.12 | 10.23 | 252 | 108101 | 43963 | 46533746 |
White blood cell count abnormal | 76.78 | 10.23 | 76 | 108277 | 5056 | 46572653 |
Injection site erythema | 75.78 | 10.23 | 39 | 108314 | 74388 | 46503321 |
Product dose omission issue | 73.20 | 10.23 | 178 | 108175 | 168342 | 46409367 |
Anaphylactic reaction | 73.10 | 10.23 | 280 | 108073 | 52832 | 46524877 |
Herpes zoster | 70.23 | 10.23 | 328 | 108025 | 67544 | 46510165 |
Inflammation | 69.48 | 10.23 | 260 | 108093 | 48521 | 46529188 |
Miosis | 67.02 | 10.23 | 80 | 108273 | 6577 | 46571132 |
Analgesic drug level increased | 66.23 | 10.23 | 42 | 108311 | 1452 | 46576257 |
Death | 63.07 | 10.23 | 488 | 107865 | 335060 | 46242649 |
Lip swelling | 62.82 | 10.23 | 164 | 108189 | 25231 | 46552478 |
Pancytopenia | 62.54 | 10.23 | 63 | 108290 | 84995 | 46492714 |
Obliterative bronchiolitis | 61.98 | 10.23 | 43 | 108310 | 1732 | 46575977 |
Injection site pain | 61.42 | 10.23 | 96 | 108257 | 107056 | 46470653 |
Asphyxia | 60.31 | 10.23 | 68 | 108285 | 5258 | 46572451 |
Cardiac failure congestive | 59.77 | 10.23 | 75 | 108278 | 91675 | 46486034 |
Somnolence | 59.16 | 10.23 | 589 | 107764 | 155932 | 46421777 |
Red blood cell sedimentation rate increased | 56.81 | 10.23 | 148 | 108205 | 22741 | 46554968 |
Wrong technique in product usage process | 56.17 | 10.23 | 28 | 108325 | 54394 | 46523315 |
Prescription form tampering | 54.11 | 10.23 | 28 | 108325 | 652 | 46577057 |
Haematemesis | 52.78 | 10.23 | 167 | 108186 | 28639 | 46549070 |
Synovitis | 52.44 | 10.23 | 280 | 108073 | 60795 | 46516914 |
Malaise | 52.30 | 10.23 | 1068 | 107285 | 330164 | 46247545 |
Device expulsion | 51.76 | 10.23 | 3 | 108350 | 27539 | 46550170 |
Musculoskeletal stiffness | 49.52 | 10.23 | 393 | 107960 | 97600 | 46480109 |
Liver function test abnormal | 49.06 | 10.23 | 226 | 108127 | 46261 | 46531448 |
Bone marrow failure | 48.24 | 10.23 | 6 | 108347 | 29663 | 46548046 |
Wrist surgery | 47.52 | 10.23 | 27 | 108326 | 761 | 46576948 |
Asthenia | 47.13 | 10.23 | 478 | 107875 | 310597 | 46267112 |
Disease progression | 46.64 | 10.23 | 88 | 108265 | 91212 | 46486497 |
Anaemia | 45.69 | 10.23 | 377 | 107976 | 255402 | 46322307 |
Platelet count decreased | 45.52 | 10.23 | 103 | 108250 | 99921 | 46477788 |
Swollen tongue | 45.16 | 10.23 | 160 | 108193 | 29072 | 46548637 |
Patient uncooperative | 44.88 | 10.23 | 16 | 108337 | 141 | 46577568 |
Serotonin syndrome | 44.00 | 10.23 | 140 | 108213 | 24080 | 46553629 |
Bradypnoea | 43.61 | 10.23 | 44 | 108309 | 2995 | 46574714 |
Overdose | 42.58 | 10.23 | 392 | 107961 | 101587 | 46476122 |
Red blood cell sedimentation rate | 41.92 | 10.23 | 34 | 108319 | 1739 | 46575970 |
Oedema peripheral | 41.46 | 10.23 | 210 | 108143 | 159496 | 46418213 |
Hospitalisation | 41.08 | 10.23 | 52 | 108301 | 63333 | 46514376 |
Hypersensitivity | 41.07 | 10.23 | 531 | 107822 | 149790 | 46427919 |
Abnormal weight gain | 40.68 | 10.23 | 31 | 108322 | 1447 | 46576262 |
Therapeutic product effect decreased | 40.48 | 10.23 | 329 | 108024 | 82272 | 46495437 |
Completed suicide | 39.68 | 10.23 | 515 | 107838 | 145405 | 46432304 |
Blister | 39.26 | 10.23 | 206 | 108147 | 44425 | 46533284 |
Gastric pH decreased | 37.54 | 10.23 | 18 | 108335 | 354 | 46577355 |
Renal papillary necrosis | 37.35 | 10.23 | 16 | 108337 | 239 | 46577470 |
Muscle injury | 37.19 | 10.23 | 51 | 108302 | 4815 | 46572894 |
Pneumonia viral | 37.09 | 10.23 | 60 | 108293 | 6564 | 46571145 |
C-reactive protein increased | 37.07 | 10.23 | 248 | 108105 | 58342 | 46519367 |
Labile blood pressure | 36.81 | 10.23 | 31 | 108322 | 1672 | 46576037 |
Derealisation | 36.66 | 10.23 | 23 | 108330 | 780 | 46576929 |
Confusional state | 36.47 | 10.23 | 547 | 107806 | 159345 | 46418364 |
Mental status changes | 35.82 | 10.23 | 22 | 108331 | 38066 | 46539643 |
Pancreatic fibrosis | 35.82 | 10.23 | 12 | 108341 | 86 | 46577623 |
Injection site swelling | 35.61 | 10.23 | 25 | 108328 | 40302 | 46537407 |
White blood cell count decreased | 35.52 | 10.23 | 137 | 108216 | 112094 | 46465615 |
Treatment failure | 34.99 | 10.23 | 350 | 108003 | 92737 | 46484972 |
Toxicologic test abnormal | 34.40 | 10.23 | 21 | 108332 | 678 | 46577031 |
Respiratory depression | 34.06 | 10.23 | 80 | 108273 | 11520 | 46566189 |
Arthralgia | 33.99 | 10.23 | 1096 | 107257 | 363507 | 46214202 |
Arteriosclerosis coronary artery | 32.90 | 10.23 | 64 | 108289 | 8092 | 46569617 |
Renal failure | 32.62 | 10.23 | 144 | 108209 | 113450 | 46464259 |
Precancerous cells present | 32.52 | 10.23 | 25 | 108328 | 1182 | 46576527 |
Haematocrit decreased | 31.94 | 10.23 | 21 | 108332 | 35036 | 46542673 |
Hallucination | 31.94 | 10.23 | 212 | 108141 | 49739 | 46527970 |
Depersonalisation/derealisation disorder | 31.87 | 10.23 | 23 | 108330 | 987 | 46576722 |
Febrile neutropenia | 31.58 | 10.23 | 113 | 108240 | 94514 | 46483195 |
Blood pressure systolic increased | 31.15 | 10.23 | 141 | 108212 | 28646 | 46549063 |
Necrosis ischaemic | 30.75 | 10.23 | 21 | 108332 | 824 | 46576885 |
Anti-cyclic citrullinated peptide antibody positive | 30.61 | 10.23 | 106 | 108247 | 19039 | 46558670 |
Pericarditis | 30.37 | 10.23 | 123 | 108230 | 23804 | 46553905 |
Sepsis | 30.32 | 10.23 | 188 | 108165 | 135826 | 46441883 |
Arthropathy | 30.17 | 10.23 | 315 | 108038 | 84385 | 46493324 |
Device related thrombosis | 30.01 | 10.23 | 24 | 108329 | 1203 | 46576506 |
C-reactive protein abnormal | 29.96 | 10.23 | 113 | 108240 | 21157 | 46556552 |
Tongue disorder | 29.60 | 10.23 | 57 | 108296 | 7153 | 46570556 |
Pituitary tumour benign | 29.14 | 10.23 | 27 | 108326 | 1654 | 46576055 |
Needle issue | 29.05 | 10.23 | 50 | 108303 | 5754 | 46571955 |
Neutropenia | 28.86 | 10.23 | 204 | 108149 | 143000 | 46434709 |
Haemoglobin decreased | 28.86 | 10.23 | 178 | 108175 | 128771 | 46448938 |
Duodenal ulcer perforation | 28.72 | 10.23 | 62 | 108291 | 8440 | 46569269 |
Sleep disorder due to general medical condition, insomnia type | 28.65 | 10.23 | 47 | 108306 | 5202 | 46572507 |
Blood pressure systolic decreased | 28.19 | 10.23 | 47 | 108306 | 5271 | 46572438 |
Dehydration | 28.06 | 10.23 | 236 | 108117 | 159304 | 46418405 |
Oral pain | 27.99 | 10.23 | 123 | 108230 | 24674 | 46553035 |
Drug use disorder | 27.75 | 10.23 | 33 | 108320 | 2702 | 46575007 |
General physical health deterioration | 26.85 | 10.23 | 158 | 108195 | 115611 | 46462098 |
Opiates positive | 26.82 | 10.23 | 13 | 108340 | 262 | 46577447 |
Deep vein thrombosis | 26.79 | 10.23 | 95 | 108258 | 79678 | 46498031 |
Respiratory failure | 26.73 | 10.23 | 121 | 108232 | 94695 | 46483014 |
Folliculitis | 26.65 | 10.23 | 50 | 108303 | 6153 | 46571556 |
Finger deformity | 26.54 | 10.23 | 45 | 108308 | 5117 | 46572592 |
Visceral congestion | 25.79 | 10.23 | 13 | 108340 | 286 | 46577423 |
Small cell carcinoma | 25.46 | 10.23 | 11 | 108342 | 168 | 46577541 |
Blood glucose increased | 25.38 | 10.23 | 84 | 108269 | 71929 | 46505780 |
Pulmonary hypertension | 24.94 | 10.23 | 28 | 108325 | 35965 | 46541744 |
Chronic obstructive pulmonary disease | 24.89 | 10.23 | 61 | 108292 | 57572 | 46520137 |
Accidental exposure to product | 24.70 | 10.23 | 9 | 108344 | 21072 | 46556637 |
Withdrawal syndrome | 24.44 | 10.23 | 95 | 108258 | 18039 | 46559670 |
Injection site pruritus | 24.32 | 10.23 | 34 | 108319 | 39709 | 46538000 |
H1N1 influenza | 24.12 | 10.23 | 23 | 108330 | 1461 | 46576248 |
Retroperitoneal fibrosis | 24.11 | 10.23 | 13 | 108340 | 330 | 46577379 |
Distributive shock | 23.98 | 10.23 | 15 | 108338 | 506 | 46577203 |
Computerised tomogram thorax abnormal | 23.86 | 10.23 | 22 | 108331 | 1339 | 46576370 |
Visual impairment | 23.74 | 10.23 | 248 | 108105 | 66441 | 46511268 |
Blood creatinine increased | 23.70 | 10.23 | 94 | 108259 | 76309 | 46501400 |
Coma | 23.19 | 10.23 | 222 | 108131 | 58127 | 46519582 |
Diaphragmatic rupture | 23 | 10.23 | 11 | 108342 | 215 | 46577494 |
Cerebrovascular accident | 22.85 | 10.23 | 139 | 108214 | 100900 | 46476809 |
Product quality issue | 22.31 | 10.23 | 30 | 108323 | 35618 | 46542091 |
Cardiomyopathy | 22.26 | 10.23 | 5 | 108348 | 16068 | 46561641 |
Swelling face | 22.15 | 10.23 | 204 | 108149 | 52855 | 46524854 |
Atrial fibrillation | 22.14 | 10.23 | 145 | 108208 | 103445 | 46474264 |
Pain | 22.08 | 10.23 | 1334 | 107019 | 475614 | 46102095 |
Muscle relaxant therapy | 21.93 | 10.23 | 9 | 108344 | 120 | 46577589 |
Tendonitis | 21.92 | 10.23 | 78 | 108275 | 14199 | 46563510 |
Blood potassium decreased | 21.89 | 10.23 | 34 | 108319 | 38029 | 46539680 |
Metastases to eye | 21.73 | 10.23 | 9 | 108344 | 123 | 46577586 |
Plasma cell myeloma | 21.72 | 10.23 | 44 | 108309 | 44434 | 46533275 |
Pneumonia streptococcal | 21.55 | 10.23 | 23 | 108330 | 1672 | 46576037 |
Accidental overdose | 21.49 | 10.23 | 98 | 108255 | 19968 | 46557741 |
Septic shock | 21.47 | 10.23 | 66 | 108287 | 57827 | 46519882 |
Helicobacter infection | 21.46 | 10.23 | 68 | 108285 | 11668 | 46566041 |
Loss of employment | 21.43 | 10.23 | 20 | 108333 | 1236 | 46576473 |
Laryngeal dyspnoea | 21.41 | 10.23 | 9 | 108344 | 128 | 46577581 |
Fear of eating | 21.13 | 10.23 | 12 | 108341 | 338 | 46577371 |
Hand deformity | 21.06 | 10.23 | 145 | 108208 | 34429 | 46543280 |
Product use issue | 20.87 | 10.23 | 322 | 108031 | 94322 | 46483387 |
Fall | 20.84 | 10.23 | 593 | 107760 | 328504 | 46249205 |
Depression | 20.79 | 10.23 | 274 | 108079 | 169830 | 46407879 |
Hyperhidrosis | 20.52 | 10.23 | 306 | 108047 | 89002 | 46488707 |
Stomatitis | 20.23 | 10.23 | 245 | 108108 | 68052 | 46509657 |
Duodenal ulcer repair | 20.23 | 10.23 | 7 | 108346 | 56 | 46577653 |
Thrombocytopenia | 20.16 | 10.23 | 192 | 108161 | 126389 | 46451320 |
Treatment noncompliance | 19.67 | 10.23 | 24 | 108329 | 29707 | 46548002 |
Coronary artery disease | 19.55 | 10.23 | 30 | 108323 | 33722 | 46543987 |
Device issue | 19.55 | 10.23 | 11 | 108342 | 19969 | 46557740 |
Alanine aminotransferase increased | 19.52 | 10.23 | 301 | 108052 | 88150 | 46489559 |
Neutropenic sepsis | 19.50 | 10.23 | 68 | 108285 | 12256 | 46565453 |
Derailment | 19.41 | 10.23 | 7 | 108346 | 64 | 46577645 |
Fibromyalgia | 19.37 | 10.23 | 148 | 108205 | 36315 | 46541394 |
Protein C increased | 19.29 | 10.23 | 9 | 108344 | 166 | 46577543 |
No adverse event | 19.28 | 10.23 | 31 | 108322 | 34200 | 46543509 |
Hepatic infiltration eosinophilic | 19.26 | 10.23 | 6 | 108347 | 33 | 46577676 |
Thiopurine methyltransferase decreased | 19.20 | 10.23 | 11 | 108342 | 315 | 46577394 |
Feeling of body temperature change | 19.18 | 10.23 | 35 | 108318 | 4217 | 46573492 |
Postmortem blood drug level abnormal | 19.14 | 10.23 | 11 | 108342 | 317 | 46577392 |
Dependence | 19.10 | 10.23 | 23 | 108330 | 1908 | 46575801 |
Mitral valve incompetence | 19.00 | 10.23 | 10 | 108343 | 18842 | 46558867 |
Mouth swelling | 18.75 | 10.23 | 32 | 108321 | 3657 | 46574052 |
Emergency care examination abnormal | 18.70 | 10.23 | 5 | 108348 | 14 | 46577695 |
Soft tissue swelling | 18.70 | 10.23 | 16 | 108337 | 882 | 46576827 |
Body temperature decreased | 18.69 | 10.23 | 71 | 108282 | 13338 | 46564371 |
Cogwheel rigidity | 18.56 | 10.23 | 20 | 108333 | 1470 | 46576239 |
Blood urea increased | 18.37 | 10.23 | 19 | 108334 | 25333 | 46552376 |
Vomiting | 18.31 | 10.23 | 1252 | 107101 | 451542 | 46126167 |
Cholelithiasis | 18.27 | 10.23 | 39 | 108314 | 38642 | 46539067 |
Abdominal pain | 18.24 | 10.23 | 679 | 107674 | 229352 | 46348357 |
Red blood cell count decreased | 17.95 | 10.23 | 30 | 108323 | 32593 | 46545116 |
Drug resistance | 17.82 | 10.23 | 9 | 108344 | 17359 | 46560350 |
Blood cholesterol increased | 17.80 | 10.23 | 156 | 108197 | 39857 | 46537852 |
Gastrointestinal stoma complication | 17.79 | 10.23 | 20 | 108333 | 1541 | 46576168 |
Fatigue | 17.76 | 10.23 | 1196 | 107157 | 607501 | 45970208 |
Acute respiratory failure | 17.76 | 10.23 | 25 | 108328 | 29113 | 46548596 |
Unevaluable event | 17.58 | 10.23 | 52 | 108301 | 46123 | 46531586 |
Pericardial effusion | 17.56 | 10.23 | 20 | 108333 | 25523 | 46552186 |
Transient ischaemic attack | 17.50 | 10.23 | 34 | 108319 | 34869 | 46542840 |
Gastrooesophageal reflux disease | 17.48 | 10.23 | 101 | 108252 | 74243 | 46503466 |
Intestinal fibrosis | 17.43 | 10.23 | 8 | 108345 | 142 | 46577567 |
Change of bowel habit | 17.39 | 10.23 | 21 | 108332 | 1747 | 46575962 |
Pulmonary function test abnormal | 17.23 | 10.23 | 18 | 108335 | 1277 | 46576432 |
Diabetes mellitus | 17.22 | 10.23 | 59 | 108294 | 50006 | 46527703 |
Skin lesion | 17.21 | 10.23 | 22 | 108331 | 26691 | 46551018 |
Swelling | 17.17 | 10.23 | 394 | 107959 | 124117 | 46453592 |
Chronic kidney disease | 17.07 | 10.23 | 44 | 108309 | 40827 | 46536882 |
Hepatic ischaemia | 17.07 | 10.23 | 12 | 108341 | 494 | 46577215 |
Oesophageal pain | 16.99 | 10.23 | 25 | 108328 | 2518 | 46575191 |
Renal impairment | 16.97 | 10.23 | 102 | 108251 | 74270 | 46503439 |
Premature labour | 16.73 | 10.23 | 61 | 108292 | 11238 | 46566471 |
Procedural anxiety | 16.65 | 10.23 | 12 | 108341 | 514 | 46577195 |
Premature delivery | 16.61 | 10.23 | 16 | 108337 | 22053 | 46555656 |
Urinary tract infection | 16.56 | 10.23 | 387 | 107966 | 219879 | 46357830 |
Dissociation | 16.39 | 10.23 | 21 | 108332 | 1856 | 46575853 |
Tendon operation | 16.38 | 10.23 | 10 | 108343 | 323 | 46577386 |
Multiple sclerosis relapse | 16.35 | 10.23 | 47 | 108306 | 42078 | 46535631 |
Fluid retention | 16.34 | 10.23 | 62 | 108291 | 50984 | 46526725 |
Intentional overdose | 16.30 | 10.23 | 226 | 108127 | 64718 | 46512991 |
Beta haemolytic streptococcal infection | 16.28 | 10.23 | 21 | 108332 | 1868 | 46575841 |
Gait disturbance | 16.28 | 10.23 | 447 | 107906 | 144816 | 46432893 |
Foetal exposure during pregnancy | 16.26 | 10.23 | 29 | 108324 | 30718 | 46546991 |
Cardiac failure | 16.04 | 10.23 | 114 | 108239 | 79834 | 46497875 |
Injection site urticaria | 16.03 | 10.23 | 4 | 108349 | 11963 | 46565746 |
Wheezing | 16.02 | 10.23 | 192 | 108161 | 53194 | 46524515 |
White blood cell count increased | 15.98 | 10.23 | 51 | 108302 | 44168 | 46533541 |
Injection site warmth | 15.93 | 10.23 | 6 | 108347 | 13766 | 46563943 |
Oedema | 15.83 | 10.23 | 91 | 108262 | 66980 | 46510729 |
Osteonecrosis | 15.78 | 10.23 | 22 | 108331 | 25722 | 46551987 |
Sensitisation | 15.71 | 10.23 | 13 | 108340 | 684 | 46577025 |
Hypersensitivity vasculitis | 15.68 | 10.23 | 32 | 108321 | 4189 | 46573520 |
Benzodiazepine drug level increased | 15.63 | 10.23 | 8 | 108345 | 182 | 46577527 |
Urticaria | 15.62 | 10.23 | 371 | 107982 | 117521 | 46460188 |
Induced abortion failed | 15.61 | 10.23 | 9 | 108344 | 261 | 46577448 |
Thrombosis | 15.53 | 10.23 | 72 | 108281 | 55997 | 46521712 |
Myocardial fibrosis | 15.53 | 10.23 | 12 | 108341 | 572 | 46577137 |
Pain in jaw | 15.50 | 10.23 | 42 | 108311 | 38330 | 46539379 |
Feeling of despair | 15.46 | 10.23 | 20 | 108333 | 1785 | 46575924 |
Injection site reaction | 15.39 | 10.23 | 58 | 108295 | 47791 | 46529918 |
Dermatitis allergic | 15.37 | 10.23 | 64 | 108289 | 12539 | 46565170 |
Pleural effusion | 15.35 | 10.23 | 121 | 108232 | 82831 | 46494878 |
Hallucinations, mixed | 15.28 | 10.23 | 30 | 108323 | 3819 | 46573890 |
Hot flush | 15.16 | 10.23 | 51 | 108302 | 43466 | 46534243 |
Device dislocation | 15.06 | 10.23 | 17 | 108336 | 21785 | 46555924 |
Costovertebral angle tenderness | 15.04 | 10.23 | 6 | 108347 | 74 | 46577635 |
Drug detoxification | 15.02 | 10.23 | 8 | 108345 | 198 | 46577511 |
Dysmetropsia | 14.97 | 10.23 | 6 | 108347 | 75 | 46577634 |
Maternal exposure during pregnancy | 14.90 | 10.23 | 159 | 108194 | 102390 | 46475319 |
Myelodysplastic syndrome | 14.88 | 10.23 | 9 | 108344 | 15702 | 46562007 |
Ileus | 14.87 | 10.23 | 7 | 108346 | 14057 | 46563652 |
Ascites | 14.81 | 10.23 | 40 | 108313 | 36544 | 46541165 |
Alveolar rhabdomyosarcoma | 14.79 | 10.23 | 5 | 108348 | 37 | 46577672 |
Blood count abnormal | 14.61 | 10.23 | 12 | 108341 | 17866 | 46559843 |
Agranulocytosis | 14.58 | 10.23 | 18 | 108335 | 22167 | 46555542 |
Peritonitis | 14.48 | 10.23 | 16 | 108337 | 20698 | 46557011 |
Limb operation | 14.46 | 10.23 | 27 | 108326 | 3311 | 46574398 |
Neuropathy peripheral | 14.41 | 10.23 | 138 | 108215 | 90755 | 46486954 |
Weight decreased | 14.34 | 10.23 | 376 | 107977 | 210473 | 46367236 |
Mite allergy | 14.24 | 10.23 | 10 | 108343 | 411 | 46577298 |
Therapy cessation | 14.18 | 10.23 | 25 | 108328 | 26604 | 46551105 |
Stubbornness | 14.10 | 10.23 | 8 | 108345 | 225 | 46577484 |
Fluid overload | 14.05 | 10.23 | 26 | 108327 | 27159 | 46550550 |
Lethargy | 14.05 | 10.23 | 181 | 108172 | 50990 | 46526719 |
Intestinal strangulation | 13.98 | 10.23 | 6 | 108347 | 90 | 46577619 |
Device related infection | 13.90 | 10.23 | 17 | 108336 | 21024 | 46556685 |
Uveal melanoma | 13.87 | 10.23 | 4 | 108349 | 16 | 46577693 |
Blood triglycerides increased | 13.85 | 10.23 | 5 | 108348 | 11778 | 46565931 |
Infective pulmonary exacerbation of cystic fibrosis | 13.74 | 10.23 | 4 | 108349 | 10803 | 46566906 |
Bacteraemia | 13.60 | 10.23 | 8 | 108345 | 14171 | 46563538 |
Carcinoid crisis | 13.57 | 10.23 | 8 | 108345 | 242 | 46577467 |
Toxic shock syndrome streptococcal | 13.41 | 10.23 | 6 | 108347 | 100 | 46577609 |
Cerebral infarction | 13.31 | 10.23 | 21 | 108332 | 23345 | 46554364 |
Respiratory rate decreased | 13.28 | 10.23 | 25 | 108328 | 3085 | 46574624 |
Fear-related avoidance of activities | 13.25 | 10.23 | 6 | 108347 | 103 | 46577606 |
Sphincter of Oddi dysfunction | 13.23 | 10.23 | 9 | 108344 | 351 | 46577358 |
Tuberculosis | 13.21 | 10.23 | 53 | 108300 | 10212 | 46567497 |
Disease recurrence | 13.21 | 10.23 | 14 | 108339 | 18457 | 46559252 |
Limb mass | 13.16 | 10.23 | 22 | 108331 | 2472 | 46575237 |
Red blood cell nucleated morphology present | 13.15 | 10.23 | 4 | 108349 | 20 | 46577689 |
Vaccination site joint pain | 13.13 | 10.23 | 3 | 108350 | 3 | 46577706 |
Irritable bowel syndrome | 13.02 | 10.23 | 74 | 108279 | 16441 | 46561268 |
Cholangiectasis acquired | 12.99 | 10.23 | 4 | 108349 | 21 | 46577688 |
Injection site bruising | 12.94 | 10.23 | 41 | 108312 | 35595 | 46542114 |
Fungal infection | 12.94 | 10.23 | 31 | 108322 | 29489 | 46548220 |
Respiratory distress | 12.84 | 10.23 | 35 | 108318 | 31881 | 46545828 |
Lymphopenia | 12.83 | 10.23 | 10 | 108343 | 15283 | 46562426 |
Product complaint | 12.83 | 10.23 | 6 | 108347 | 12095 | 46565614 |
Parosmia | 12.76 | 10.23 | 29 | 108324 | 4087 | 46573622 |
Pubic pain | 12.73 | 10.23 | 5 | 108348 | 59 | 46577650 |
Abortion induced | 12.68 | 10.23 | 4 | 108349 | 10256 | 46567453 |
Anterograde amnesia | 12.66 | 10.23 | 9 | 108344 | 377 | 46577332 |
Off label use | 12.66 | 10.23 | 737 | 107616 | 379104 | 46198605 |
Seizure | 12.65 | 10.23 | 205 | 108148 | 122849 | 46454860 |
Premature baby | 12.65 | 10.23 | 14 | 108339 | 18098 | 46559611 |
Caesarean section | 12.54 | 10.23 | 12 | 108341 | 16591 | 46561118 |
Hypotension | 12.53 | 10.23 | 428 | 107925 | 232161 | 46345548 |
Gallbladder cholesterolosis | 12.50 | 10.23 | 12 | 108341 | 769 | 46576940 |
Urine output decreased | 12.49 | 10.23 | 55 | 108298 | 11042 | 46566667 |
Cholesteatoma | 12.47 | 10.23 | 6 | 108347 | 119 | 46577590 |
Oral contusion | 12.44 | 10.23 | 5 | 108348 | 63 | 46577646 |
Infrequent bowel movements | 12.30 | 10.23 | 14 | 108339 | 1094 | 46576615 |
COVID-19 | 12.28 | 10.23 | 15 | 108338 | 18560 | 46559149 |
Adverse drug reaction | 12.27 | 10.23 | 57 | 108296 | 44305 | 46533404 |
Exposure during pregnancy | 12.24 | 10.23 | 177 | 108176 | 108035 | 46469674 |
Anxiety | 12.23 | 10.23 | 325 | 108028 | 181632 | 46396077 |
Ill-defined disorder | 12.14 | 10.23 | 105 | 108248 | 26722 | 46550987 |
Shock | 12.10 | 10.23 | 20 | 108333 | 21825 | 46555884 |
Influenza like illness | 12.09 | 10.23 | 81 | 108272 | 57489 | 46520220 |
Escherichia infection | 12.04 | 10.23 | 5 | 108348 | 10812 | 46566897 |
Hyperprolinaemia | 12.02 | 10.23 | 4 | 108349 | 28 | 46577681 |
Jaw clicking | 12.02 | 10.23 | 4 | 108349 | 28 | 46577681 |
Lung infiltration | 12.01 | 10.23 | 9 | 108344 | 14034 | 46563675 |
Bulimia nervosa | 11.94 | 10.23 | 10 | 108343 | 535 | 46577174 |
Haemophilus test positive | 11.92 | 10.23 | 3 | 108350 | 6 | 46577703 |
Ataxia | 11.82 | 10.23 | 9 | 108344 | 13921 | 46563788 |
Musculoskeletal disorder | 11.82 | 10.23 | 69 | 108284 | 15476 | 46562233 |
Pyroglutamate increased | 11.81 | 10.23 | 9 | 108344 | 420 | 46577289 |
Antisocial behaviour | 11.81 | 10.23 | 7 | 108346 | 214 | 46577495 |
Acute interstitial pneumonitis | 11.80 | 10.23 | 11 | 108342 | 679 | 46577030 |
Multiple sclerosis | 11.70 | 10.23 | 25 | 108328 | 24766 | 46552943 |
Suspected counterfeit product | 11.65 | 10.23 | 8 | 108345 | 317 | 46577392 |
Hernia | 11.64 | 10.23 | 49 | 108304 | 9646 | 46568063 |
Duodenal ulcer | 11.57 | 10.23 | 40 | 108313 | 7178 | 46570531 |
External ear disorder | 11.56 | 10.23 | 4 | 108349 | 32 | 46577677 |
Cranial sutures widening | 11.56 | 10.23 | 4 | 108349 | 32 | 46577677 |
Acute chest syndrome | 11.55 | 10.23 | 10 | 108343 | 560 | 46577149 |
Pneumocystis jirovecii pneumonia | 11.54 | 10.23 | 11 | 108342 | 15237 | 46562472 |
Drug diversion | 11.51 | 10.23 | 12 | 108341 | 849 | 46576860 |
Meningorrhagia | 11.47 | 10.23 | 6 | 108347 | 143 | 46577566 |
Neurotoxicity | 11.47 | 10.23 | 9 | 108344 | 13708 | 46564001 |
Progressive multifocal leukoencephalopathy | 11.46 | 10.23 | 6 | 108347 | 11340 | 46566369 |
Strabismus congenital | 11.45 | 10.23 | 4 | 108349 | 33 | 46577676 |
Cholecystitis chronic | 11.45 | 10.23 | 5 | 108348 | 10494 | 46567215 |
Deformity | 11.44 | 10.23 | 40 | 108313 | 7217 | 46570492 |
Peritonitis bacterial | 11.38 | 10.23 | 3 | 108350 | 8650 | 46569059 |
Lip infection | 11.36 | 10.23 | 5 | 108348 | 80 | 46577629 |
Electrolyte imbalance | 11.29 | 10.23 | 14 | 108339 | 17212 | 46560497 |
Sacroiliitis | 11.27 | 10.23 | 19 | 108334 | 2150 | 46575559 |
Acute myeloid leukaemia | 11.23 | 10.23 | 12 | 108341 | 15766 | 46561943 |
Eosinophilia | 11.21 | 10.23 | 17 | 108336 | 19200 | 46558509 |
Hyperlipidaemia | 11.20 | 10.23 | 16 | 108337 | 18523 | 46559186 |
Blood loss anaemia | 11.19 | 10.23 | 3 | 108350 | 8554 | 46569155 |
Muscular weakness | 11.18 | 10.23 | 148 | 108205 | 91696 | 46486013 |
Dermal sinus | 11.05 | 10.23 | 4 | 108349 | 37 | 46577672 |
Device malfunction | 10.90 | 10.23 | 9 | 108344 | 13365 | 46564344 |
Agitation | 10.89 | 10.23 | 185 | 108168 | 55230 | 46522479 |
Cafe au lait spots | 10.86 | 10.23 | 4 | 108349 | 39 | 46577670 |
Neoplasm malignant | 10.84 | 10.23 | 24 | 108329 | 23475 | 46554234 |
Schizophrenia | 10.83 | 10.23 | 44 | 108309 | 8524 | 46569185 |
Intestinal ulcer perforation | 10.83 | 10.23 | 3 | 108350 | 10 | 46577699 |
Haemophagocytic lymphohistiocytosis | 10.77 | 10.23 | 3 | 108350 | 8339 | 46569370 |
Libido increased | 10.75 | 10.23 | 11 | 108342 | 761 | 46576948 |
Underdose | 10.75 | 10.23 | 18 | 108335 | 19540 | 46558169 |
Therapy non-responder | 10.72 | 10.23 | 54 | 108299 | 41098 | 46536611 |
Product prescribing issue | 10.72 | 10.23 | 12 | 108341 | 920 | 46576789 |
Abnormal palmar/plantar creases | 10.60 | 10.23 | 4 | 108349 | 42 | 46577667 |
Periorbital cellulitis | 10.60 | 10.23 | 9 | 108344 | 491 | 46577218 |
Sinusitis | 10.59 | 10.23 | 225 | 108128 | 129543 | 46448166 |
Restless legs syndrome | 10.58 | 10.23 | 68 | 108285 | 15775 | 46561934 |
Pancreatitis acute | 10.56 | 10.23 | 96 | 108257 | 24776 | 46552933 |
Staphylococcal infection | 10.47 | 10.23 | 45 | 108308 | 35726 | 46541983 |
Thyroid adenoma | 10.44 | 10.23 | 6 | 108347 | 173 | 46577536 |
Alanine aminotransferase abnormal | 10.40 | 10.23 | 20 | 108333 | 2507 | 46575202 |
Naevus haemorrhage | 10.35 | 10.23 | 5 | 108348 | 100 | 46577609 |
Hyperglycaemia | 10.34 | 10.23 | 44 | 108309 | 35027 | 46542682 |
Lactic acidosis | 10.33 | 10.23 | 42 | 108311 | 33867 | 46543842 |
Emphysema | 10.28 | 10.23 | 45 | 108308 | 9009 | 46568700 |
Urinary retention | 10.27 | 10.23 | 99 | 108254 | 25962 | 46551747 |
Tricuspid valve incompetence | 10.26 | 10.23 | 10 | 108343 | 13707 | 46564002 |
Injection site induration | 10.25 | 10.23 | 3 | 108350 | 8076 | 46569633 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 1550.61 | 10.57 | 1164 | 45312 | 80908 | 29825094 |
Toxicity to various agents | 1322.62 | 10.57 | 1492 | 44984 | 175691 | 29730311 |
Drug hypersensitivity | 420.02 | 10.57 | 524 | 45952 | 67995 | 29838007 |
Substance abuse | 241.06 | 10.57 | 145 | 46331 | 6895 | 29899107 |
Prescription form tampering | 228.21 | 10.57 | 68 | 46408 | 502 | 29905500 |
Overdose | 218.18 | 10.57 | 434 | 46042 | 83903 | 29822099 |
Drug dependence | 165.24 | 10.57 | 184 | 46292 | 21111 | 29884891 |
Intentional product misuse | 155.40 | 10.57 | 228 | 46248 | 34439 | 29871563 |
Intentional overdose | 92.45 | 10.57 | 201 | 46275 | 41280 | 29864722 |
Poisoning | 84.25 | 10.57 | 96 | 46380 | 11286 | 29894716 |
Poisoning deliberate | 75.51 | 10.57 | 67 | 46409 | 5837 | 29900165 |
Drug ineffective | 71.78 | 10.57 | 279 | 46197 | 340108 | 29565894 |
Completed suicide | 71.63 | 10.57 | 325 | 46151 | 99167 | 29806835 |
Lower respiratory tract infection | 65.95 | 10.57 | 135 | 46341 | 26579 | 29879423 |
Asphyxia | 58.56 | 10.57 | 56 | 46420 | 5369 | 29900633 |
Depressed level of consciousness | 50.45 | 10.57 | 152 | 46324 | 38070 | 29867932 |
Drug use disorder | 50.00 | 10.57 | 41 | 46435 | 3207 | 29902795 |
Miosis | 43.59 | 10.57 | 57 | 46419 | 7719 | 29898283 |
Respiratory depression | 43.54 | 10.57 | 70 | 46406 | 11433 | 29894569 |
Duodenal ulcer perforation | 40.91 | 10.57 | 28 | 46448 | 1664 | 29904338 |
Somnolence | 38.16 | 10.57 | 269 | 46207 | 96494 | 29809508 |
Myocardial infarction | 33.96 | 10.57 | 92 | 46384 | 125533 | 29780469 |
Nightmare | 33.37 | 10.57 | 64 | 46412 | 12012 | 29893990 |
Malaise | 32.60 | 10.57 | 399 | 46077 | 166563 | 29739439 |
Off label use | 32.02 | 10.57 | 241 | 46235 | 249049 | 29656953 |
Bradypnoea | 31.15 | 10.57 | 25 | 46451 | 1896 | 29904106 |
Respiratory arrest | 31.04 | 10.57 | 108 | 46368 | 29150 | 29876852 |
Poor feeding infant | 30.90 | 10.57 | 14 | 46462 | 367 | 29905635 |
Prescription drug used without a prescription | 30.79 | 10.57 | 21 | 46455 | 1241 | 29904761 |
Analgesic drug level increased | 30.72 | 10.57 | 16 | 46460 | 573 | 29905429 |
Pseudoporphyria | 28.77 | 10.57 | 12 | 46464 | 256 | 29905746 |
Peripheral circulatory failure | 27.94 | 10.57 | 11 | 46465 | 201 | 29905801 |
Coma scale abnormal | 27.60 | 10.57 | 30 | 46446 | 3346 | 29902656 |
Neutropenic sepsis | 27.37 | 10.57 | 57 | 46419 | 11352 | 29894650 |
Chronic gastrointestinal bleeding | 25.81 | 10.57 | 11 | 46465 | 248 | 29905754 |
Chemical poisoning | 25.66 | 10.57 | 9 | 46467 | 117 | 29905885 |
Anaemia | 24.85 | 10.57 | 205 | 46271 | 207787 | 29698215 |
Perineal pain | 24.77 | 10.57 | 14 | 46462 | 591 | 29905411 |
Multiple organ dysfunction syndrome | 24.35 | 10.57 | 38 | 46438 | 63449 | 29842553 |
Cytomegalovirus infection | 23.88 | 10.57 | 4 | 46472 | 23670 | 29882332 |
Calcium deficiency | 23.67 | 10.57 | 9 | 46467 | 149 | 29905853 |
Pulmonary congestion | 23.42 | 10.57 | 56 | 46420 | 12231 | 29893771 |
Pulmonary oedema | 23.38 | 10.57 | 132 | 46344 | 43843 | 29862159 |
Agitated depression | 23.24 | 10.57 | 10 | 46466 | 231 | 29905771 |
Mouth ulceration | 23.15 | 10.57 | 51 | 46425 | 10558 | 29895444 |
Sepsis | 23.06 | 10.57 | 133 | 46343 | 146262 | 29759740 |
Spinal cord infection | 23.03 | 10.57 | 9 | 46467 | 161 | 29905841 |
Cardiac failure congestive | 22.66 | 10.57 | 62 | 46414 | 84345 | 29821657 |
Drug interaction | 22.33 | 10.57 | 434 | 46042 | 199134 | 29706868 |
Anal ulcer | 22.27 | 10.57 | 13 | 46463 | 584 | 29905418 |
Mouth swelling | 22.16 | 10.57 | 19 | 46457 | 1580 | 29904422 |
Product dose omission issue | 21.93 | 10.57 | 71 | 46405 | 91560 | 29814442 |
Otospondylomegaepiphyseal dysplasia | 21.53 | 10.57 | 8 | 46468 | 124 | 29905878 |
Febrile neutropenia | 21.38 | 10.57 | 89 | 46387 | 106604 | 29799398 |
Drug resistance | 21.22 | 10.57 | 3 | 46473 | 20130 | 29885872 |
Lip swelling | 21.05 | 10.57 | 55 | 46421 | 12689 | 29893313 |
Liver function test abnormal | 20.67 | 10.57 | 99 | 46377 | 30851 | 29875151 |
Weight decrease neonatal | 20.03 | 10.57 | 10 | 46466 | 327 | 29905675 |
Nervous system neoplasm | 19.93 | 10.57 | 8 | 46468 | 154 | 29905848 |
Analgesic drug level above therapeutic | 19.86 | 10.57 | 9 | 46467 | 236 | 29905766 |
Swelling face | 19.72 | 10.57 | 75 | 46401 | 21129 | 29884873 |
Cardio-respiratory arrest | 19.55 | 10.57 | 154 | 46322 | 57152 | 29848850 |
Pyrexia | 19.39 | 10.57 | 331 | 46145 | 294158 | 29611844 |
Orthostatic hypotension | 19.24 | 10.57 | 81 | 46395 | 23898 | 29882104 |
Alice in wonderland syndrome | 19.14 | 10.57 | 5 | 46471 | 21 | 29905981 |
Anal fissure | 19.12 | 10.57 | 21 | 46455 | 2370 | 29903632 |
General physical health deterioration | 19.02 | 10.57 | 85 | 46391 | 99859 | 29806143 |
Overgrowth bacterial | 18.92 | 10.57 | 7 | 46469 | 107 | 29905895 |
Renal failure | 18.82 | 10.57 | 120 | 46356 | 128846 | 29777156 |
Morganella infection | 18.78 | 10.57 | 10 | 46466 | 375 | 29905627 |
Ulcer | 18.77 | 10.57 | 36 | 46440 | 6755 | 29899247 |
Arteriosclerosis coronary artery | 18.22 | 10.57 | 48 | 46428 | 11128 | 29894874 |
Accidental overdose | 18.13 | 10.57 | 66 | 46410 | 18209 | 29887793 |
Gangrene neonatal | 17.79 | 10.57 | 8 | 46468 | 206 | 29905796 |
Disease progression | 17.68 | 10.57 | 64 | 46412 | 79810 | 29826192 |
Osmolar gap abnormal | 17.01 | 10.57 | 5 | 46471 | 35 | 29905967 |
Genitalia external ambiguous | 16.85 | 10.57 | 8 | 46468 | 234 | 29905768 |
Phlebosclerosis | 16.84 | 10.57 | 7 | 46469 | 148 | 29905854 |
Exposure via breast milk | 16.54 | 10.57 | 16 | 46460 | 1556 | 29904446 |
Blood pressure fluctuation | 16.35 | 10.57 | 62 | 46414 | 17441 | 29888561 |
Linear IgA disease | 16.28 | 10.57 | 16 | 46460 | 1586 | 29904416 |
Vomiting | 16.20 | 10.57 | 451 | 46025 | 219367 | 29686635 |
Withdrawal syndrome | 16.04 | 10.57 | 46 | 46430 | 11204 | 29894798 |
Idiopathic pulmonary fibrosis | 15.72 | 10.57 | 25 | 46451 | 4044 | 29901958 |
Rhinalgia | 15.71 | 10.57 | 9 | 46467 | 390 | 29905612 |
Gastrointestinal mucosa hyperaemia | 15.50 | 10.57 | 7 | 46469 | 182 | 29905820 |
Inferior vena cava dilatation | 15.19 | 10.57 | 7 | 46469 | 191 | 29905811 |
Bronchial haemorrhage | 15.15 | 10.57 | 11 | 46465 | 718 | 29905284 |
Sleep deficit | 15.14 | 10.57 | 9 | 46467 | 418 | 29905584 |
Secondary hypogonadism | 15.09 | 10.57 | 8 | 46468 | 297 | 29905705 |
Congenital bladder anomaly | 15.07 | 10.57 | 8 | 46468 | 298 | 29905704 |
Product use in unapproved indication | 15.05 | 10.57 | 61 | 46415 | 73632 | 29832370 |
Skin turgor decreased | 15.05 | 10.57 | 9 | 46467 | 423 | 29905579 |
Moaning | 14.81 | 10.57 | 11 | 46465 | 744 | 29905258 |
Overlap syndrome | 14.77 | 10.57 | 5 | 46471 | 58 | 29905944 |
Increased bronchial secretion | 14.61 | 10.57 | 14 | 46462 | 1345 | 29904657 |
Apparent life threatening event | 14.52 | 10.57 | 7 | 46469 | 212 | 29905790 |
Maternal exposure during breast feeding | 14.22 | 10.57 | 15 | 46461 | 1617 | 29904385 |
Anomaly of external ear congenital | 14.17 | 10.57 | 6 | 46470 | 133 | 29905869 |
External auditory canal atresia | 13.93 | 10.57 | 6 | 46470 | 139 | 29905863 |
Aspartate aminotransferase increased | 13.91 | 10.57 | 51 | 46425 | 63371 | 29842631 |
Hospitalisation | 13.90 | 10.57 | 30 | 46446 | 44289 | 29861713 |
Platelet count decreased | 13.86 | 10.57 | 102 | 46374 | 106027 | 29799975 |
Patient dissatisfaction with treatment | 13.85 | 10.57 | 5 | 46471 | 71 | 29905931 |
Accidental poisoning | 13.77 | 10.57 | 9 | 46467 | 495 | 29905507 |
Palpitations | 13.60 | 10.57 | 94 | 46382 | 33479 | 29872523 |
Foetal hypokinesia | 13.51 | 10.57 | 8 | 46468 | 369 | 29905633 |
Gastrointestinal ulcer | 13.48 | 10.57 | 15 | 46461 | 1717 | 29904285 |
Depression suicidal | 13.45 | 10.57 | 13 | 46463 | 1263 | 29904739 |
Hyponatraemic seizure | 13.42 | 10.57 | 5 | 46471 | 78 | 29905924 |
Crystalluria | 13.39 | 10.57 | 8 | 46468 | 375 | 29905627 |
Suicide attempt | 13.28 | 10.57 | 100 | 46376 | 36597 | 29869405 |
Depressed mood | 13.26 | 10.57 | 57 | 46419 | 16972 | 29889030 |
Foaming at mouth | 13.25 | 10.57 | 10 | 46466 | 693 | 29905309 |
Therapeutic response decreased | 13.22 | 10.57 | 11 | 46465 | 24338 | 29881664 |
Delirium | 13.20 | 10.57 | 108 | 46368 | 40523 | 29865479 |
Self-medication | 13.14 | 10.57 | 17 | 46459 | 2277 | 29903725 |
Leukopenia | 13.09 | 10.57 | 44 | 46432 | 56115 | 29849887 |
Adrenergic syndrome | 13.03 | 10.57 | 5 | 46471 | 85 | 29905917 |
Confusional state | 13.01 | 10.57 | 287 | 46189 | 134547 | 29771455 |
Treatment noncompliance | 12.99 | 10.57 | 12 | 46464 | 25241 | 29880761 |
Coronary artery disease | 12.97 | 10.57 | 37 | 46439 | 49675 | 29856327 |
Thrombocytopenia | 12.96 | 10.57 | 143 | 46333 | 136901 | 29769101 |
Drug diversion | 12.93 | 10.57 | 11 | 46465 | 905 | 29905097 |
Mucosal inflammation | 12.92 | 10.57 | 17 | 46459 | 30477 | 29875525 |
Wrong patient received product | 12.89 | 10.57 | 15 | 46461 | 1802 | 29904200 |
Injection site pain | 12.74 | 10.57 | 17 | 46459 | 30293 | 29875709 |
Paratracheal lymphadenopathy | 12.72 | 10.57 | 5 | 46471 | 91 | 29905911 |
Premature baby | 12.68 | 10.57 | 5 | 46471 | 16686 | 29889316 |
Cluster headache | 12.60 | 10.57 | 9 | 46467 | 573 | 29905429 |
Injection site erythema | 12.57 | 10.57 | 3 | 46473 | 13831 | 29892171 |
Mental status changes | 12.56 | 10.57 | 24 | 46452 | 37055 | 29868947 |
Clumsiness | 12.53 | 10.57 | 13 | 46463 | 1374 | 29904628 |
Neonatal respiratory depression | 12.49 | 10.57 | 8 | 46468 | 425 | 29905577 |
Pancytopenia | 12.46 | 10.57 | 79 | 46397 | 84973 | 29821029 |
Hyporesponsive to stimuli | 12.46 | 10.57 | 11 | 46465 | 951 | 29905051 |
Plasma cell myeloma | 12.39 | 10.57 | 42 | 46434 | 53420 | 29852582 |
Intercepted product prescribing error | 12.06 | 10.57 | 5 | 46471 | 105 | 29905897 |
Defaecation urgency | 11.97 | 10.57 | 13 | 46463 | 1448 | 29904554 |
Skin fragility | 11.97 | 10.57 | 8 | 46468 | 457 | 29905545 |
Peripheral artery thrombosis | 11.95 | 10.57 | 16 | 46460 | 2216 | 29903786 |
Psychomotor skills impaired | 11.86 | 10.57 | 15 | 46461 | 1964 | 29904038 |
Pouchitis | 11.62 | 10.57 | 9 | 46467 | 648 | 29905354 |
Drug withdrawal syndrome neonatal | 11.58 | 10.57 | 19 | 46457 | 3156 | 29902846 |
Asthenia | 11.41 | 10.57 | 259 | 46217 | 221031 | 29684971 |
Atrial fibrillation | 11.37 | 10.57 | 110 | 46366 | 108014 | 29797988 |
Medication overuse headache | 11.34 | 10.57 | 4 | 46472 | 53 | 29905949 |
Haematocrit decreased | 11.18 | 10.57 | 19 | 46457 | 30680 | 29875322 |
Male sexual dysfunction | 11.03 | 10.57 | 6 | 46470 | 235 | 29905767 |
Therapy non-responder | 10.94 | 10.57 | 18 | 46458 | 29435 | 29876567 |
Visceral congestion | 10.84 | 10.57 | 8 | 46468 | 536 | 29905466 |
Ejection fraction decreased | 10.80 | 10.57 | 5 | 46471 | 15170 | 29890832 |
Tendon discomfort | 10.75 | 10.57 | 6 | 46470 | 247 | 29905755 |
Social problem | 10.74 | 10.57 | 9 | 46467 | 725 | 29905277 |
Fat redistribution | 10.73 | 10.57 | 5 | 46471 | 140 | 29905862 |
Tooth injury | 10.58 | 10.57 | 9 | 46467 | 741 | 29905261 |
Source | Code | Description |
---|---|---|
ATC | R05DA04 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Opium alkaloids and derivatives |
ATC | N02AA59 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | N02AA79 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | N02AJ06 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
ATC | N02AJ07 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
ATC | N02AJ08 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
ATC | N02AJ09 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
FDA MoA | N0000175684 | Full Opioid Agonists |
FDA EPC | N0000175690 | Opioid Agonist |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000701 | Analgesics, Opioid |
MeSH PA | D000996 | Antitussive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009294 | Narcotics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D019141 | Respiratory System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35482 | narcotic analgesics |
CHEBI has role | CHEBI:35703 | xenobiotic |
CHEBI has role | CHEBI:50266 | prodrugs |
CHEBI has role | CHEBI:51177 | cough suppressant |
CHEBI has role | CHEBI:60606 | opioid receptor agonists |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pain | indication | 22253000 | |
Cough | indication | 49727002 | |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Rhinitis | indication | 70076002 | DOID:4483 |
Sneezing | indication | 76067001 | |
Common cold | indication | 82272006 | DOID:10459 |
Headache disorder | indication | 230461009 | |
Sore throat symptom | indication | 267102003 | |
Influenza-like symptoms | indication | 315642008 | |
Fever | indication | 386661006 | |
Tension-type headache | indication | 398057008 | |
Muscle Spasm with Pain | indication | ||
Diarrhea | off-label use | 62315008 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Goiter | contraindication | 3716002 | DOID:12176 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Gastritis | contraindication | 4556007 | DOID:4029 |
Suicidal thoughts | contraindication | 6471006 | |
Dependent drug abuse | contraindication | 6525002 | |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Hyperammonemia | contraindication | 9360008 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Asthenia | contraindication | 13791008 | |
Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
Hyperkalemia | contraindication | 14140009 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Chronic disease of respiratory system | contraindication | 17097001 | |
Mood swings | contraindication | 18963009 | |
Lowered convulsive threshold | contraindication | 19260006 | |
Hashimoto thyroiditis | contraindication | 21983002 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Disorder of the central nervous system | contraindication | 23853001 | DOID:331 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Ventricular tachycardia | contraindication | 25569003 | |
Acute tuberculosis | contraindication | 25629007 | |
Alcohol intoxication | contraindication | 25702006 | |
Shock | contraindication | 27942005 | |
Hypercapnia | contraindication | 29596007 | |
Bronchitis | contraindication | 32398004 | DOID:6132 |
Dehydration | contraindication | 34095006 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Depressive disorder | contraindication | 35489007 | |
Acute hepatitis | contraindication | 37871000 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Body fluid retention | contraindication | 43498006 | |
Hyperactive behavior | contraindication | 44548000 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Acidosis | contraindication | 51387008 | |
Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
Nasal polyp | contraindication | 52756005 | |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Arterial thrombosis | contraindication | 65198009 | |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Psychotic disorder | contraindication | 69322001 | |
Poisoning by acetaminophen | contraindication | 70273001 | |
Agoraphobia | contraindication | 70691001 | DOID:593 |
Arteriosclerotic vascular disease | contraindication | 72092001 | |
Sedation | contraindication | 72641008 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Factor II deficiency | contraindication | 73975000 | |
Reye's syndrome | contraindication | 74351001 | DOID:14525 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Urethral stricture | contraindication | 76618002 | |
Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
Decreased respiratory function | contraindication | 80954004 | |
Disorder of brain | contraindication | 81308009 | DOID:936 |
Injury of head | contraindication | 82271004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Pulmonary emphysema | contraindication | 87433001 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Hemophilia | contraindication | 90935002 | |
Dermatitis herpetiformis | contraindication | 111196000 | DOID:8505 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Acute abdominal pain | contraindication | 116290004 | |
Procedure on urinary system | contraindication | 118677009 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
von Willebrand disorder | contraindication | 128105004 | DOID:12531 |
Seizure disorder | contraindication | 128613002 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
Insomnia | contraindication | 193462001 | |
Partial atrioventricular block | contraindication | 195039008 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Acute intermittent porphyria | contraindication | 234422006 | DOID:3890 |
Gastroesophageal reflux disease | contraindication | 235595009 | DOID:8534 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Morbid obesity | contraindication | 238136002 | DOID:11981 |
Hypocomplementemic urticarial vasculitis | contraindication | 239945009 | |
Pyloric obstruction | contraindication | 244815007 | |
Sleep automatism | contraindication | 247962006 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Exacerbation of asthma | contraindication | 281239006 | |
Pregnancy, function | contraindication | 289908002 | |
Lesion of brain | contraindication | 301766008 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Panic disorder | contraindication | 371631005 | DOID:594 |
Coma | contraindication | 371632003 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Operation on gastrointestinal tract | contraindication | 386621005 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Cardiovascular event risk | contraindication | 395112001 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Respiratory insufficiency | contraindication | 409623005 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Central nervous system depression | contraindication | 418072004 | |
Porphyria | contraindication | 418470004 | |
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 422681000 | |
Poor metabolizer due to cytochrome p450 CYP2C19 variant | contraindication | 424500005 | |
Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
Hypertensive urgency | contraindication | 443482000 | |
Acute erosive gastritis | contraindication | 444926003 | |
Acute exacerbation of asthma | contraindication | 708038006 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.38 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | Ki | 6.14 | CHEMBL | CHEMBL | |||
Kappa-type opioid receptor | GPCR | AGONIST | Ki | 4.59 | CHEMBL | ||||
Delta-type opioid receptor | GPCR | AGONIST | Ki | 4.28 | CHEMBL | ||||
Opioid receptor | GPCR | IC50 | 8 | CHEMBL |
ID | Source |
---|---|
4017509 | VUID |
N0000145894 | NUI |
D00195 | KEGG_DRUG |
6059-47-8 | SECONDARY_CAS_RN |
4017414 | VANDF |
4017415 | VANDF |
4017509 | VANDF |
4019491 | VANDF |
C0009214 | UMLSCUI |
CHEBI:16714 | CHEBI |
5284371 | PUBCHEM_CID |
CHEMBL485 | ChEMBL_ID |
CHEMBL369475 | ChEMBL_ID |
CHEMBL1201099 | ChEMBL_ID |
CHEMBL1159819 | ChEMBL_ID |
CHEMBL1201463 | ChEMBL_ID |
CHEMBL284671 | ChEMBL_ID |
CHEMBL4297091 | ChEMBL_ID |
DB00318 | DRUGBANK_ID |
D003061 | MESH_DESCRIPTOR_UI |
1673 | IUPHAR_LIGAND_ID |
Q830PW7520 | UNII |
1545976 | RXNORM |
32159 | MMSL |
4490 | MMSL |
4491 | MMSL |
4492 | MMSL |
4675 | MMSL |
4676 | MMSL |
d00012 | MMSL |
001550 | NDDF |
001551 | NDDF |
001552 | NDDF |
001553 | NDDF |
005189 | NDDF |
1476002 | SNOMEDCT_US |
261000 | SNOMEDCT_US |
387494007 | SNOMEDCT_US |
85990009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Fiorinal with Codeine | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0023-6010 | CAPSULE | 30 mg | ORAL | NDA | 36 sections |
Codeine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0243 | TABLET | 15 mg | ORAL | NDA | 32 sections |
Codeine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0244 | TABLET | 30 mg | ORAL | NDA | 32 sections |
Codeine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0245 | TABLET | 60 mg | ORAL | NDA | 32 sections |
Acetaminophen and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-0050 | TABLET | 15 mg | ORAL | ANDA | 27 sections |
Acetaminophen and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-0150 | TABLET | 30 mg | ORAL | ANDA | 27 sections |
Acetaminophen and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-0350 | TABLET | 60 mg | ORAL | ANDA | 27 sections |
Acetaminophen and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0504 | SOLUTION | 12 mg | ORAL | ANDA | 34 sections |
PROMETHAZINE HYDROCHLORIDE AND CODEINE PHOSPHATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0547 | SYRUP | 10 mg | ORAL | ANDA | 30 sections |
Guaifenesin and Codeine Phosphate | HUMAN OTC DRUG LABEL | 2 | 0121-0775 | SOLUTION | 10 mg | ORAL | OTC monograph final | 16 sections |
Promethazine VC with Codeine Oral Solution | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0121-0925 | SOLUTION | 10 mg | ORAL | ANDA | 29 sections |
Promethazine with Codeine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0928 | SOLUTION | 10 mg | ORAL | ANDA | 29 sections |
Acetaminophen and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-1008 | SOLUTION | 30 mg | ORAL | ANDA | 34 sections |
Guaifenesin and Codeine Phosphate | HUMAN OTC DRUG LABEL | 2 | 0121-1550 | SOLUTION | 10 mg | ORAL | OTC monograph final | 16 sections |
Guaifenesin and Codeine Phosphate | HUMAN OTC DRUG LABEL | 2 | 0121-1775 | SOLUTION | 10 mg | ORAL | OTC monograph final | 16 sections |
ACETAMINOPHEN AND CODEINE PHOSPHATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0406-0483 | TABLET | 15 mg | ORAL | ANDA | 15 sections |
ACETAMINOPHEN AND CODEINE PHOSPHATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0406-0484 | TABLET | 30 mg | ORAL | ANDA | 15 sections |
ACETAMINOPHEN AND CODEINE PHOSPHATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0406-0485 | TABLET | 60 mg | ORAL | ANDA | 15 sections |
Acetaminophen And Codeine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0440-7026 | TABLET | 30 mg | ORAL | ANDA | 31 sections |
Acetaminophen And Codeine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0440-7027 | TABLET | 60 mg | ORAL | ANDA | 31 sections |
Butalbital, Aspirin, Caffeine and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0527-1312 | CAPSULE | 30 mg | ORAL | ANDA | 25 sections |
Codeine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1698 | TABLET | 30 mg | ORAL | ANDA | 32 sections |
Codeine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1699 | TABLET | 60 mg | ORAL | ANDA | 32 sections |
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0591-2641 | CAPSULE | 30 mg | ORAL | ANDA | 27 sections |
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0591-3220 | CAPSULE | 30 mg | ORAL | NDA AUTHORIZED GENERIC | 32 sections |
Butalbital, Aspirin, Caffeine and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0591-3546 | CAPSULE | 30 mg | ORAL | NDA authorized generic | 36 sections |
Acetaminophen And Codeine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0603-2337 | TABLET | 15 mg | ORAL | ANDA | 34 sections |
Acetaminophen And Codeine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0603-2338 | TABLET | 30 mg | ORAL | ANDA | 34 sections |
Acetaminophen And Codeine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0603-2339 | TABLET | 60 mg | ORAL | ANDA | 34 sections |
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0603-2553 | CAPSULE | 30 mg | ORAL | ANDA | 35 sections |