propranolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 2303 525-66-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propranolol
  • betalong
  • DL-Propranolol
  • racemic propranolol
  • beta-Propranolol
  • propranolol hydrochloride
  • hemangiol
  • propranolol HCl
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
  • Molecular weight: 259.35
  • Formula: C16H21NO2
  • CLOGP: 2.75
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.49
  • ALOGS: -3.51
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.16 g O
0.16 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 35.25 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 26 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 13, 1967 FDA BAXTER HLTHCARE CORP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 673.50 9.72 846 65907 137355 53144958
Product administered to patient of inappropriate age 430.36 9.72 154 66599 2682 53279631
Toxicity to various agents 423.01 9.72 881 65872 218717 53063596
Bradycardia 368.00 9.72 449 66304 70607 53211706
Cardiac arrest 274.80 9.72 451 66302 93216 53189097
Overdose 224.37 9.72 447 66306 107289 53175024
Rheumatoid arthritis 223.44 9.72 59 66694 314472 52967841
Migraine 183.65 9.72 347 66406 80070 53202243
Intentional overdose 158.42 9.72 294 66459 66911 53215402
Hypotension 156.68 9.72 681 66072 253395 53028918
Coma 147.78 9.72 272 66481 61511 53220802
Cardio-respiratory arrest 120.05 9.72 242 66511 58516 53223797
Electrocardiogram QRS complex prolonged 112.85 9.72 77 66676 5665 53276648
Drug interaction 110.18 9.72 554 66199 218775 53063538
Joint swelling 108.62 9.72 81 66672 234557 53047756
Cardiogenic shock 107.92 9.72 121 66632 17361 53264952
Respiratory arrest 107.12 9.72 168 66585 33372 53248941
Synovitis 99.09 9.72 10 66743 107883 53174430
Electrocardiogram QT prolonged 97.48 9.72 217 66536 56186 53226127
Suicidal ideation 97.03 9.72 226 66527 60285 53222028
Seizure 94.56 9.72 366 66387 129143 53153170
Systemic lupus erythematosus 86.13 9.72 25 66728 125389 53156924
Thyrotoxic crisis 83.93 9.72 33 66720 753 53281560
Hypoglycaemia 83.47 9.72 210 66543 58803 53223510
Glossodynia 83.11 9.72 13 66740 100278 53182035
Hand deformity 83.00 9.72 6 66747 84843 53197470
Infusion related reaction 82.83 9.72 46 66707 155911 53126402
Wound 82.75 9.72 9 66744 91548 53190765
Pulseless electrical activity 82.47 9.72 71 66682 7383 53274930
Sinus bradycardia 81.59 9.72 96 66657 14505 53267808
Circulatory collapse 81.33 9.72 120 66633 22594 53259719
Drug withdrawal syndrome 76.80 9.72 131 66622 27891 53254422
Drug ineffective for unapproved indication 74.96 9.72 110 66643 20610 53261703
Peripheral coldness 74.72 9.72 80 66673 10899 53271414
Brain injury 72.88 9.72 62 66691 6343 53275970
Infantile spitting up 71.55 9.72 16 66737 38 53282275
Contraindicated product administered 70.59 9.72 41 66712 135588 53146725
Sleep terror 68.27 9.72 29 66724 811 53281502
Nightmare 68.24 9.72 97 66656 17654 53264659
Tremor 67.60 9.72 324 66429 125412 53156901
Hyperthyroidism 66.58 9.72 82 66671 12991 53269322
Suicide attempt 65.20 9.72 190 66563 57978 53224335
Arthropathy 61.42 9.72 52 66701 141401 53140912
Phaeochromocytoma 60.94 9.72 24 66729 550 53281763
Hypoglycaemic seizure 59.23 9.72 23 66730 507 53281806
Pericarditis 59.04 9.72 6 66747 64400 53217913
Peripheral swelling 58.72 9.72 105 66648 206003 53076310
Ulcerated haemangioma 56.85 9.72 10 66743 0 53282313
Hepatic encephalopathy 56.73 9.72 69 66684 10790 53271523
Arthralgia 56.12 9.72 322 66431 439461 52842852
Swelling 53.85 9.72 98 66655 191007 53091306
Poisoning deliberate 53.24 9.72 60 66693 8653 53273660
Respiratory depression 52.24 9.72 72 66681 12734 53269579
Infection 51.53 9.72 85 66668 172120 53110193
Pain 50.55 9.72 482 66271 587916 52694397
Hepatic enzyme increased 49.35 9.72 51 66702 126144 53156169
Lower respiratory tract infection 48.05 9.72 27 66726 90954 53191359
Abdominal discomfort 47.11 9.72 132 66621 220930 53061383
Pneumonia 46.77 9.72 308 66445 406861 52875452
Rash 46.61 9.72 347 66406 445844 52836469
Retinal detachment 45.88 9.72 45 66708 5530 53276783
Shock 45.68 9.72 94 66659 23045 53259268
Therapeutic product effect decreased 45.60 9.72 54 66699 125601 53156712
Neovascularisation 44.95 9.72 20 66733 627 53281686
Somnolence 44.84 9.72 361 66392 167373 53114940
Brain death 44.60 9.72 34 66719 2974 53279339
Alopecia 43.66 9.72 149 66604 234434 53047879
Hyperhidrosis 43.32 9.72 237 66516 96556 53185757
Panic attack 42.27 9.72 87 66666 21331 53260982
Disturbance in attention 42.12 9.72 116 66637 34267 53248046
Depressed level of consciousness 41.46 9.72 156 66597 54272 53228041
Extrapyramidal disorder 40.81 9.72 63 66690 12339 53269974
Insulin autoimmune syndrome 40.39 9.72 11 66742 72 53282241
Eosinophilic myocarditis 39.63 9.72 16 66737 392 53281921
Nasopharyngitis 38.65 9.72 118 66635 192177 53090136
Oesophageal varices haemorrhage 37.68 9.72 22 66731 1231 53281082
Hyperreflexia 37.41 9.72 40 66713 5440 53276873
Electrocardiogram QRS complex shortened 37.25 9.72 16 66737 460 53281853
Stomatitis 36.89 9.72 41 66712 98117 53184196
Disease progression 36.76 9.72 44 66709 101876 53180437
Anuria 36.54 9.72 60 66693 12380 53269933
Somatic delusion 36.47 9.72 17 66736 595 53281718
Palpitations 36.42 9.72 236 66517 102112 53180201
Galactorrhoea 36.19 9.72 34 66719 3961 53278352
Akathisia 36.18 9.72 49 66704 8522 53273791
Foetal alcohol syndrome 35.48 9.72 8 66745 20 53282293
Helicobacter infection 34.89 9.72 4 66749 39065 53243248
Anxiety 33.97 9.72 386 66367 196318 53085995
Depression 33.80 9.72 364 66389 182688 53099625
Atrioventricular block 33.51 9.72 43 66710 7097 53275216
Metabolic acidosis 32.94 9.72 122 66631 42120 53240193
Loss of consciousness 32.81 9.72 250 66503 113962 53168351
Pyrexia 32.55 9.72 335 66418 402858 52879455
Paradoxical drug reaction 31.47 9.72 29 66724 3296 53279017
Impaired healing 31.19 9.72 21 66732 64184 53218129
Hypersensitivity 30.85 9.72 147 66606 210518 53071795
Sinusitis 30.71 9.72 108 66645 168456 53113857
Rheumatoid factor positive 30.59 9.72 7 66746 41191 53241122
Exposure via ingestion 30.06 9.72 28 66725 3227 53279086
Varices oesophageal 29.94 9.72 27 66726 2985 53279328
Mydriasis 29.78 9.72 52 66701 11274 53271039
Hallucination, auditory 29.60 9.72 53 66700 11720 53270593
Infusion site streaking 29.38 9.72 13 66740 402 53281911
Lethargy 29.19 9.72 139 66614 53621 53228692
Neuropathy peripheral 28.97 9.72 53 66700 103134 53179179
Maternal exposure during pregnancy 28.83 9.72 99 66654 155540 53126773
Dizziness 28.73 9.72 638 66115 371621 52910692
Ear infection 28.43 9.72 84 66669 25816 53256497
Vision blurred 28.40 9.72 194 66559 85410 53196903
Hallucination 28.37 9.72 138 66615 53700 53228613
Hypothermia 28.11 9.72 55 66698 13001 53269312
Hepatocellular carcinoma 27.49 9.72 26 66727 3054 53279259
Serotonin syndrome 27.44 9.72 84 66669 26322 53255991
Poisoning 27.03 9.72 56 66697 13794 53268519
Fatigue 26.83 9.72 703 66050 729803 52552510
Pain in extremity 26.77 9.72 228 66525 284822 52997491
Agoraphobia 26.29 9.72 12 66741 400 53281913
Hyperthermia 26.08 9.72 42 66711 8527 53273786
Hyperammonaemic encephalopathy 25.71 9.72 21 66732 2030 53280283
Drug ineffective 25.59 9.72 804 65949 816441 52465872
Irritability 25.49 9.72 91 66662 30862 53251451
Panic reaction 25.32 9.72 28 66725 3955 53278358
Interstitial lung disease 24.88 9.72 22 66731 58600 53223713
Agitation 24.53 9.72 141 66612 58485 53223828
Withdrawal syndrome 24.52 9.72 66 66687 19235 53263078
Accessory cardiac pathway 24.49 9.72 5 66748 6 53282307
Cyanosis 24.34 9.72 60 66693 16579 53265734
Generalised tonic-clonic seizure 24.07 9.72 85 66668 28673 53253640
Apraxia 23.98 9.72 19 66734 1759 53280554
Derailment 23.66 9.72 7 66746 64 53282249
Febrile neutropenia 23.57 9.72 61 66692 104875 53177438
Dystonia 23.50 9.72 51 66702 12970 53269343
Discomfort 23.42 9.72 53 66700 95419 53186894
Inappropriate schedule of product administration 23.26 9.72 167 66586 74711 53207602
Accelerated idioventricular rhythm 23.08 9.72 6 66747 32 53282281
Atrioventricular block first degree 22.63 9.72 34 66719 6501 53275812
Musculoskeletal stiffness 22.49 9.72 79 66674 123289 53159024
Coma scale abnormal 22.46 9.72 30 66723 5148 53277165
Haemoglobin decreased 22.39 9.72 92 66661 137215 53145098
Neutropenia 22.19 9.72 113 66640 159072 53123241
Ventricular arrhythmia 22.01 9.72 25 66728 3635 53278678
Retroperitoneal fibrosis 21.61 9.72 10 66743 344 53281969
Unresponsive to stimuli 21.58 9.72 91 66662 33335 53248978
Product use in unapproved indication 21.50 9.72 225 66528 112064 53170249
Essential tremor 21.38 9.72 14 66739 961 53281352
Gastrointestinal disorder 21.25 9.72 51 66702 89953 53192360
Pleural effusion 21.06 9.72 50 66703 88529 53193784
Cholestasis of pregnancy 20.93 9.72 15 66738 1194 53281119
Herpes zoster 20.79 9.72 38 66715 73981 53208332
Narrow anterior chamber angle 20.67 9.72 6 66747 51 53282262
Infantile haemangioma 20.17 9.72 6 66747 56 53282257
Death 20.16 9.72 320 66433 356912 52925401
Cough 20.06 9.72 215 66538 256678 53025635
Suspected suicide 20.02 9.72 26 66727 4342 53277971
Lip swelling 19.91 9.72 77 66676 27124 53255189
Porphyrins urine increased 19.84 9.72 5 66748 23 53282290
Acquired porphyria 19.84 9.72 5 66748 23 53282290
C-reactive protein increased 19.83 9.72 34 66719 67852 53214461
Pituitary apoplexy 19.77 9.72 7 66746 118 53282195
Heart rate decreased 19.67 9.72 95 66658 36852 53245461
Vascular malformation 19.66 9.72 9 66744 302 53282011
Therapeutic product ineffective for unapproved indication 19.59 9.72 8 66745 202 53282111
Haematemesis 19.15 9.72 83 66670 30774 53251539
Blister 19.09 9.72 44 66709 78709 53203604
Muscle contractions involuntary 18.74 9.72 18 66735 2155 53280158
Porphyrins stool increased 18.73 9.72 5 66748 30 53282283
Hallucination, visual 18.73 9.72 59 66694 18773 53263540
Confusional state 18.64 9.72 344 66409 193877 53088436
Tardive dyskinesia 18.61 9.72 35 66718 8035 53274278
Sleep disorder due to general medical condition, insomnia type 18.35 9.72 4 66749 24345 53257968
Urinary tract infection 18.24 9.72 202 66551 239701 53042612
Gynaecomastia 18.17 9.72 7 66746 151 53282162
Torsade de pointes 18.08 9.72 46 66707 12959 53269354
Poor quality sleep 17.90 9.72 55 66698 17268 53265045
Mental disorder 17.84 9.72 69 66684 24307 53258006
Therapeutic product effective for unapproved indication 17.84 9.72 6 66747 86 53282227
Tearfulness 17.83 9.72 24 66729 4150 53278163
Drug intolerance 17.68 9.72 168 66585 205325 53076988
Jaundice 17.65 9.72 80 66673 30233 53252080
Laryngeal dyspnoea 17.63 9.72 7 66746 164 53282149
Off label use 17.58 9.72 740 66013 471472 52810841
Perseveration 17.57 9.72 8 66745 265 53282048
Migraine with aura 17.56 9.72 18 66735 2332 53279981
Paraganglion neoplasm 17.47 9.72 4 66749 11 53282302
Vertigo 17.37 9.72 125 66628 55956 53226357
Thyroxine free decreased 17.30 9.72 10 66743 549 53281764
Self-injurious ideation 17.26 9.72 18 66735 2378 53279935
Wrong patient received product 17.18 9.72 17 66736 2111 53280202
Asthma 17.15 9.72 74 66679 108898 53173415
Ventricular tachycardia 17.07 9.72 55 66698 17707 53264606
Haemodynamic instability 17.06 9.72 35 66718 8559 53273754
Thyrotoxic cardiomyopathy 17.06 9.72 3 66750 0 53282313
Urine amphetamine positive 16.87 9.72 5 66748 46 53282267
Muscle rigidity 16.83 9.72 40 66713 10801 53271512
Oedema peripheral 16.74 9.72 135 66618 170652 53111661
Adrenal suppression 16.69 9.72 12 66741 960 53281353
Paranasal cyst 16.63 9.72 8 66745 301 53282012
Bezoar 16.47 9.72 14 66739 1430 53280883
Chemical burn 16.38 9.72 9 66744 448 53281865
Defect conduction intraventricular 16.33 9.72 6 66747 113 53282200
Treatment failure 16.31 9.72 94 66659 128309 53154004
Knee arthroplasty 16.27 9.72 11 66742 33558 53248755
Depressed mood 16.18 9.72 90 66663 36874 53245439
Pulse absent 16.14 9.72 26 66727 5280 53277033
Teething 15.94 9.72 4 66749 18 53282295
Hepatic steatosis 15.81 9.72 70 66683 26189 53256124
Tumour rupture 15.77 9.72 6 66747 125 53282188
Exposure via transplant 15.60 9.72 4 66749 20 53282293
Food craving 15.43 9.72 14 66739 1560 53280753
Disorientation 15.39 9.72 93 66660 39266 53243047
Ventricular fibrillation 15.37 9.72 41 66712 11884 53270429
Inappropriate affect 15.32 9.72 11 66742 878 53281435
Sleep disorder 15.32 9.72 126 66627 58744 53223569
Mobility decreased 15.16 9.72 47 66706 76224 53206089
Cerebral vasoconstriction 15.14 9.72 12 66741 1111 53281202
Abnormal weight gain 15.06 9.72 14 66739 1609 53280704
Chromaturia 14.98 9.72 49 66704 15901 53266412
Sinus rhythm 14.95 9.72 10 66743 712 53281601
Intentional self-injury 14.92 9.72 67 66686 25217 53257096
Progressive supranuclear palsy 14.84 9.72 5 66748 72 53282241
Bradycardia foetal 14.73 9.72 8 66745 389 53281924
Hypoperfusion 14.65 9.72 13 66740 1407 53280906
Salivary hypersecretion 14.65 9.72 29 66724 6914 53275399
Somnambulism 14.46 9.72 25 66728 5377 53276936
Blood prolactin increased 14.41 9.72 19 66734 3220 53279093
Acute lung injury 14.33 9.72 13 66740 1448 53280865
Productive cough 14.31 9.72 31 66722 56698 53225615
Depersonalisation/derealisation disorder 14.30 9.72 12 66741 1205 53281108
Neuroleptic malignant syndrome 14.14 9.72 40 66713 11993 53270320
Oculogyric crisis 14.13 9.72 13 66740 1475 53280838
Memory impairment 14.01 9.72 165 66588 84592 53197721
Dyspnoea exertional 13.92 9.72 30 66723 54970 53227343
Congenital pharyngeal anomaly 13.77 9.72 3 66750 6 53282307
Hip arthroplasty 13.68 9.72 9 66744 27853 53254460
Monoclonal gammopathy 13.42 9.72 9 66744 643 53281670
Ill-defined disorder 13.34 9.72 26 66727 49418 53232895
Breast cancer 13.28 9.72 26 66727 49332 53232981
Hyperbilirubinaemia 13.21 9.72 37 66716 11032 53271281
Cytomegalovirus infection 13.21 9.72 4 66749 19535 53262778
Hepatic cirrhosis 13.18 9.72 51 66702 17971 53264342
Dermatitis diaper 13.03 9.72 6 66747 204 53282109
Macroglossia 13.03 9.72 9 66744 675 53281638
Basilar migraine 13.02 9.72 4 66749 42 53282271
Dissociation 13.00 9.72 15 66738 2219 53280094
Suicidal behaviour 12.95 9.72 16 66737 2542 53279771
Malignant neoplasm progression 12.90 9.72 46 66707 71495 53210818
Nervousness 12.89 9.72 73 66680 30105 53252208
Cerebellar syndrome 12.83 9.72 19 66734 3588 53278725
Bundle branch block 12.82 9.72 10 66743 905 53281408
Feeling guilty 12.81 9.72 8 66745 506 53281807
Breath holding 12.64 9.72 6 66747 219 53282094
Pruritus 12.58 9.72 276 66477 293556 52988757
Ear discomfort 12.50 9.72 28 66725 7273 53275040
Pupil fixed 12.40 9.72 13 66740 1729 53280584
Aggression 12.33 9.72 60 66693 23343 53258970
Alveolar bone resorption 12.32 9.72 4 66749 51 53282262
Hypermobility syndrome 12.31 9.72 9 66744 739 53281574
Renal disorder 12.28 9.72 11 66742 29128 53253185
Gastrointestinal motility disorder 12.26 9.72 22 66731 4874 53277439
Aspiration of gastric residual 12.24 9.72 3 66750 12 53282301
Inflammation 12.23 9.72 34 66719 57102 53225211
Abnormal dreams 12.23 9.72 35 66718 10566 53271747
Aphasia 12.21 9.72 73 66680 30705 53251608
Abnormal faeces 12.16 9.72 21 66732 4513 53277800
International normalised ratio increased 12.13 9.72 26 66727 47735 53234578
Feeling abnormal 12.06 9.72 237 66516 135064 53147249
Sepsis 12.05 9.72 121 66632 146308 53136005
Stress ulcer 12.04 9.72 4 66749 55 53282258
Tri-iodothyronine decreased 12.00 9.72 5 66748 133 53282180
Altered state of consciousness 11.91 9.72 62 66691 24774 53257539
Metastases to liver 11.90 9.72 6 66747 21490 53260823
Agranulocytosis 11.88 9.72 60 66693 23689 53258624
Swollen tongue 11.87 9.72 73 66680 31007 53251306
Product complaint 11.82 9.72 38 66715 12219 53270094
Therapeutic product effect incomplete 11.76 9.72 67 66686 91717 53190596
Wound infection bacterial 11.64 9.72 7 66746 414 53281899
Thyroid cancer metastatic 11.63 9.72 5 66748 144 53282169
Blood pressure systolic decreased 11.61 9.72 24 66729 5900 53276413
Mood swings 11.60 9.72 48 66705 17438 53264875
Intentional product use issue 11.55 9.72 49 66704 72445 53209868
Dyspnoea 11.53 9.72 608 66145 585624 52696689
Bundle branch block right 11.51 9.72 22 66731 5111 53277202
Change in seizure presentation 11.50 9.72 6 66747 269 53282044
Septic arthritis staphylococcal 11.37 9.72 7 66746 432 53281881
Palmar erythema 11.34 9.72 12 66741 1612 53280701
Ventricular failure 11.34 9.72 7 66746 434 53281879
Sinoatrial block 11.31 9.72 9 66744 838 53281475
Formication 11.28 9.72 19 66734 4002 53278311
Drug dependence 11.28 9.72 55 66698 21417 53260896
Thyroxine free increased 11.16 9.72 9 66744 855 53281458
Apathy 11.14 9.72 29 66724 8283 53274030
Hyperprolactinaemia 11.13 9.72 17 66736 3298 53279015
Portal vein thrombosis 11.10 9.72 15 66738 2604 53279709
Postresuscitation encephalopathy 10.97 9.72 3 66750 20 53282293
Back pain 10.91 9.72 217 66536 234030 53048283
Atrophy 10.88 9.72 12 66741 1690 53280623
Irritable bowel syndrome 10.88 9.72 24 66729 43608 53238705
Broad ligament tear 10.84 9.72 3 66750 21 53282292
Arrhythmia 10.83 9.72 81 66672 36698 53245615
Muscle twitching 10.82 9.72 45 66708 16381 53265932
Oromandibular dystonia 10.79 9.72 7 66746 473 53281840
Cutaneous lupus erythematosus 10.64 9.72 15 66738 2708 53279605
Lung disorder 10.62 9.72 28 66725 47851 53234462
Capillary nail refill test abnormal 10.61 9.72 3 66750 23 53282290
Tongue pruritus 10.58 9.72 7 66746 489 53281824
Acne pustular 10.57 9.72 4 66749 82 53282231
Nodal rhythm 10.55 9.72 12 66741 1748 53280565
Transposition of the great vessels 10.54 9.72 5 66748 182 53282131
Arthritis 10.51 9.72 65 66688 87233 53195080
Drug level increased 10.51 9.72 52 66701 20369 53261944
Haemorrhagic tumour necrosis 10.49 9.72 3 66750 24 53282289
Rhythm idioventricular 10.42 9.72 5 66748 187 53282126
Brugada syndrome 10.40 9.72 6 66747 328 53281985
Pharyngeal oedema 10.40 9.72 41 66712 14572 53267741
Porphyria non-acute 10.32 9.72 6 66747 333 53281980
Basedow's disease 10.32 9.72 6 66747 333 53281980
Actinic keratosis 10.29 9.72 14 66739 2444 53279869
Tonic convulsion 10.25 9.72 10 66743 1221 53281092
Multiple lentigines syndrome 10.22 9.72 5 66748 195 53282118
Electrocardiogram QT interval 10.22 9.72 4 66749 90 53282223
Oedema 10.22 9.72 53 66700 74293 53208020
Supraventricular tachycardia 10.04 9.72 40 66713 14285 53268028
Thalamic infarction 9.97 9.72 7 66746 539 53281774
Pneumocystis jirovecii pneumonia 9.96 9.72 4 66749 16374 53265939
Psychotic disorder 9.77 9.72 58 66695 24327 53257986
VIth nerve paralysis 9.76 9.72 8 66745 777 53281536
Amnesia 9.75 9.72 93 66660 45195 53237118

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 313.21 11.04 456 37197 92061 32383812
Hepatic encephalopathy 213.90 11.04 160 37493 14735 32461138
Bradycardia 211.06 11.04 331 37322 71231 32404642
Toxicity to various agents 193.45 11.04 546 37107 177495 32298378
Product administered to patient of inappropriate age 186.05 11.04 82 37571 2724 32473149
Hyperthyroidism 100.95 11.04 85 37568 9277 32466596
Ascites 100.89 11.04 173 37480 40018 32435855
Cardiac arrest 100.12 11.04 292 37361 96484 32379389
Oesophageal varices haemorrhage 84.15 11.04 50 37603 3129 32472744
Varices oesophageal 75.19 11.04 49 37604 3612 32472261
Parasomnia 75.18 11.04 25 37628 375 32475498
Hepatic cirrhosis 75.14 11.04 95 37558 16714 32459159
Akathisia 74.13 11.04 63 37590 6962 32468911
Myokymia 64.30 11.04 16 37637 76 32475797
Hepatocellular carcinoma 64.25 11.04 69 37584 10201 32465672
Hepatorenal syndrome 63.30 11.04 39 37614 2606 32473267
Drug interaction 62.33 11.04 449 37204 217736 32258137
Encapsulating peritoneal sclerosis 62.20 11.04 25 37628 656 32475217
Intentional overdose 61.97 11.04 144 37509 41457 32434416
Overdose 59.88 11.04 229 37424 86848 32389025
Febrile neutropenia 59.74 11.04 32 37621 119534 32356339
Pneumonia 55.46 11.04 218 37435 355034 32120839
Cardio-respiratory arrest 47.68 11.04 158 37495 55831 32420042
Tremor 46.54 11.04 202 37451 81075 32394798
Cerebral artery thrombosis 43.24 11.04 19 37634 626 32475247
Suicidal ideation 42.31 11.04 118 37535 37965 32437908
Respiratory arrest 39.72 11.04 97 37556 28811 32447062
Nightmare 37.47 11.04 60 37593 13106 32462767
Aggression 37.02 11.04 115 37538 39274 32436599
Granulomatous rosacea 36.65 11.04 12 37641 171 32475702
Sedation 35.46 11.04 71 37582 18455 32457418
Poisoning deliberate 34.99 11.04 40 37613 6335 32469538
Photophobia 34.54 11.04 40 37613 6424 32469449
Brain scan abnormal 34.35 11.04 17 37636 737 32475136
Thyrotoxic crisis 34.22 11.04 14 37639 385 32475488
Foetal disorder 34.01 11.04 17 37636 753 32475120
Thyrotoxic periodic paralysis 33.47 11.04 9 37644 61 32475812
Anxiety 32.35 11.04 206 37447 95799 32380074
Infantile spitting up 31.81 11.04 8 37645 40 32475833
Abnormal sleep-related event 31.26 11.04 14 37639 483 32475390
Suicidal behaviour 30.97 11.04 20 37633 1451 32474422
Migraine 30.94 11.04 57 37596 13928 32461945
Hyperhidrosis 30.66 11.04 163 37490 71005 32404868
Neutropenia neonatal 30.33 11.04 15 37638 649 32475224
Psychotic disorder 30.31 11.04 76 37577 22944 32452929
Granulocytopenia 29.39 11.04 37 37616 6478 32469395
Irritability 28.98 11.04 78 37575 24576 32451297
Disturbance in attention 28.78 11.04 76 37577 23677 32452196
Areflexia 28.73 11.04 25 37628 2851 32473022
Premature baby 28.55 11.04 65 37588 18453 32457420
Dyspnoea 28.15 11.04 276 37377 361769 32114104
Peripheral coldness 27.91 11.04 37 37616 6816 32469057
Product use issue 27.80 11.04 128 37525 52649 32423224
Phaeochromocytoma malignant 27.76 11.04 8 37645 72 32475801
Sinus bradycardia 27.71 11.04 52 37601 12886 32462987
Portal vein thrombosis 26.78 11.04 27 37626 3708 32472165
Hallucination, auditory 26.53 11.04 45 37608 10305 32465568
Portal hypertensive gastropathy 26.52 11.04 13 37640 552 32475321
Tardive dyskinesia 25.89 11.04 32 37621 5499 32470374
Myocardial infarction 25.88 11.04 68 37585 125608 32350265
Heat stroke 25.16 11.04 15 37638 944 32474929
Neutrophil count decreased 24.44 11.04 12 37641 47127 32428746
Lethargy 23.98 11.04 103 37550 41125 32434748
Cardiogenic shock 23.91 11.04 65 37588 20597 32455276
Gastroenteritis eosinophilic 23.74 11.04 9 37644 201 32475672
Agitation 23.23 11.04 129 37524 57107 32418766
Portal hypertension 23.15 11.04 26 37627 4038 32471835
Infantile haemangioma 23.05 11.04 4 37649 0 32475873
Platelet count decreased 22.84 11.04 63 37590 114528 32361345
Malignant neoplasm progression 22.54 11.04 35 37618 78461 32397412
White blood cell count decreased 22.27 11.04 45 37608 91153 32384720
Acute stress disorder 21.88 11.04 8 37645 161 32475712
Joint swelling 21.52 11.04 17 37636 51718 32424155
Anhidrosis 21.49 11.04 7 37646 98 32475775
Torsade de pointes 21.38 11.04 34 37619 7381 32468492
Sepsis 21.30 11.04 103 37550 158731 32317142
Myocardial depression 21.02 11.04 6 37647 52 32475821
Peritoneal fibrosis 20.81 11.04 4 37649 3 32475870
Antipsychotic drug level increased 20.74 11.04 23 37630 3523 32472350
Coma 20.72 11.04 101 37552 42511 32433362
Interstitial lung disease 20.62 11.04 27 37626 64974 32410899
Disorientation 20.60 11.04 85 37568 33340 32442533
Sleep disorder 20.57 11.04 73 37580 26679 32449194
Differential white blood cell count abnormal 20.46 11.04 15 37638 1337 32474536
Neutropenia 20.36 11.04 90 37563 142085 32333788
Hepatitis C 20.34 11.04 47 37606 13471 32462402
Suicide attempt 20.31 11.04 93 37560 38151 32437722
Hepatopulmonary syndrome 20.05 11.04 5 37648 24 32475849
Alcoholic liver disease 19.93 11.04 11 37642 598 32475275
Hepatic failure 19.88 11.04 88 37565 35592 32440281
Drug withdrawal syndrome 19.87 11.04 60 37593 20171 32455702
Sexually inappropriate behaviour 19.78 11.04 10 37643 454 32475419
Cardiac failure congestive 19.77 11.04 43 37610 84809 32391064
Hepatitis C RNA positive 19.32 11.04 8 37645 227 32475646
Restlessness 19.22 11.04 68 37585 24813 32451060
Pulseless electrical activity 19.19 11.04 31 37622 6819 32469054
Oesophageal variceal ligation 18.83 11.04 6 37647 78 32475795
Low birth weight baby 18.71 11.04 31 37622 6963 32468910
Hypoaesthesia eye 18.71 11.04 5 37648 33 32475840
Somnolence 18.66 11.04 193 37460 103604 32372269
Plasma cell myeloma 18.21 11.04 24 37629 57590 32418283
Rash 18.20 11.04 155 37498 209178 32266695
Pseudoporphyria 18.17 11.04 8 37645 265 32475608
Poisoning 18.13 11.04 40 37613 11118 32464755
Withdrawal syndrome 18.08 11.04 42 37611 12080 32463793
Rheumatoid arthritis 18.08 11.04 15 37638 44529 32431344
Ammonia increased 18.02 11.04 24 37629 4440 32471433
Meningitis streptococcal 17.98 11.04 5 37648 39 32475834
Poor quality sleep 17.97 11.04 33 37620 8041 32467832
Respiratory rate decreased 17.93 11.04 16 37637 1886 32473987
Pyrexia 17.89 11.04 262 37391 319706 32156167
Disease progression 17.87 11.04 47 37606 86815 32389058
Phonophobia 17.81 11.04 7 37646 173 32475700
Electrocardiogram QRS complex shortened 17.81 11.04 7 37646 173 32475700
Tinnitus 17.74 11.04 52 37601 17197 32458676
Psychomotor hyperactivity 17.72 11.04 35 37618 9004 32466869
Blood creatinine increased 17.59 11.04 55 37598 96077 32379796
Social avoidant behaviour 17.43 11.04 20 37633 3179 32472694
Alcoholism 17.26 11.04 21 37632 3551 32472322
Genital swelling 17.16 11.04 7 37646 191 32475682
Binocular eye movement disorder 17.06 11.04 5 37648 48 32475825
Ventricular arrhythmia 17.06 11.04 25 37628 5054 32470819
Phaeochromocytoma 16.96 11.04 7 37646 197 32475676
Drooling 16.94 11.04 20 37633 3277 32472596
Persecutory delusion 16.94 11.04 17 37636 2322 32473551
Lupus-like syndrome 16.89 11.04 17 37636 2330 32473543
Hepatic cancer 16.64 11.04 30 37623 7210 32468663
Hypotonia 16.59 11.04 31 37622 7656 32468217
Renal impairment 16.56 11.04 53 37600 91919 32383954
Hypotension 16.46 11.04 346 37307 215764 32260109
Depression 16.29 11.04 178 37475 96882 32378991
Dysmorphism 16.13 11.04 18 37635 2775 32473098
Product use in unapproved indication 16.08 11.04 163 37490 87041 32388832
Stomatitis 15.77 11.04 14 37639 40215 32435658
Hypoglycaemia 15.49 11.04 112 37541 54270 32421603
Alcohol interaction 15.42 11.04 16 37637 2273 32473600
Unresponsive to stimuli 15.30 11.04 68 37585 27541 32448332
Renal hamartoma 15.21 11.04 3 37650 3 32475870
Strangulated umbilical hernia 15.21 11.04 3 37650 3 32475870
Agoraphobia 15.05 11.04 7 37646 264 32475609
Insomnia 15.03 11.04 180 37473 100168 32375705
Hypertrophic cardiomyopathy 14.94 11.04 11 37642 987 32474886
Genotype drug resistance test positive 14.88 11.04 14 37639 1767 32474106
Death 14.82 11.04 334 37319 382183 32093690
Heart rate decreased 14.68 11.04 63 37590 25137 32450736
Depressed level of consciousness 14.58 11.04 89 37564 40758 32435115
Atrioventricular block first degree 14.57 11.04 25 37628 5778 32470095
Essential tremor 14.38 11.04 10 37643 820 32475053
Gastric varices 14.29 11.04 8 37645 447 32475426
Biliary anastomosis 14.19 11.04 4 37649 33 32475840
Patient dissatisfaction with treatment 14.09 11.04 5 37648 92 32475781
Micrographia 14.00 11.04 3 37650 6 32475867
Laryngeal erythema 14.00 11.04 3 37650 6 32475867
Endotoxaemia 14.00 11.04 3 37650 6 32475867
Sleep deficit 13.87 11.04 8 37645 473 32475400
Encephalopathy 13.75 11.04 77 37576 34180 32441693
Chronic obstructive pulmonary disease 13.74 11.04 22 37631 48731 32427142
Pain 13.68 11.04 145 37508 187411 32288462
Reflux gastritis 13.46 11.04 7 37646 337 32475536
Nephrolithiasis 13.41 11.04 65 37588 27289 32448584
Reversible airways obstruction 13.41 11.04 7 37646 340 32475533
Wrong strength 13.39 11.04 5 37648 107 32475766
Negative thoughts 13.37 11.04 9 37644 700 32475173
Tachycardia 13.24 11.04 145 37508 78943 32396930
Hypotonia neonatal 13.24 11.04 11 37642 1178 32474695
Pain in extremity 13.23 11.04 82 37571 118819 32357054
Acute myeloid leukaemia 13.21 11.04 3 37650 19171 32456702
Product communication issue 13.05 11.04 5 37648 115 32475758
Defect conduction intraventricular 13.03 11.04 6 37647 221 32475652
Delusion 12.99 11.04 39 37614 13069 32462804
Seizure 12.90 11.04 180 37473 103674 32372199
Spindle cell sarcoma 12.90 11.04 5 37648 119 32475754
Muscle disorder 12.88 11.04 15 37638 2422 32473451
Thyroxine free increased 12.83 11.04 6 37647 229 32475644
Affective disorder 12.76 11.04 18 37635 3515 32472358
Pruritus 12.70 11.04 92 37561 128610 32347263
Mucosal inflammation 12.67 11.04 12 37641 33422 32442451
Hyperkalaemia 12.67 11.04 130 37523 69620 32406253
Cryoglobulinaemia 12.51 11.04 7 37646 391 32475482
Accessory cardiac pathway 12.47 11.04 3 37650 12 32475861
Foetal growth restriction 12.41 11.04 19 37634 3993 32471880
Pneumonitis 12.41 11.04 10 37643 30124 32445749
Extrapyramidal disorder 12.37 11.04 36 37617 11859 32464014
Goitre 12.25 11.04 12 37641 1592 32474281
Hypnagogic hallucination 12.22 11.04 4 37649 57 32475816
Gastric hypomotility 12.09 11.04 4 37649 59 32475814
Right-to-left cardiac shunt 12.09 11.04 4 37649 59 32475814
Foetal death 12.08 11.04 6 37647 262 32475611
Salivary hypersecretion 12.03 11.04 28 37625 8060 32467813
Acute myocardial infarction 11.99 11.04 29 37624 55120 32420753
Arthralgia 11.97 11.04 112 37541 148336 32327537
Action tremor 11.97 11.04 4 37649 61 32475812
Ventricular pre-excitation 11.93 11.04 3 37650 15 32475858
Ventricular septal defect 11.91 11.04 18 37635 3739 32472134
Hallucination, visual 11.66 11.04 45 37608 17114 32458759
Depressed mood 11.64 11.04 47 37606 18253 32457620
Exposure via ingestion 11.62 11.04 14 37639 2343 32473530
Congenital hypothyroidism 11.62 11.04 3 37650 17 32475856
Cognitive disorder 11.61 11.04 60 37593 25834 32450039
Maternal drugs affecting foetus 11.50 11.04 19 37634 4258 32471615
Loss of bladder sensation 11.46 11.04 4 37649 70 32475803
Neuropathy peripheral 11.46 11.04 48 37605 76934 32398939
Secondary hypogonadism 11.31 11.04 6 37647 301 32475572
Mood altered 11.30 11.04 29 37624 8875 32466998
Serotonin syndrome 11.29 11.04 48 37605 19069 32456804
Intentional product misuse 11.29 11.04 76 37577 35975 32439898
Peripheral swelling 11.20 11.04 41 37612 68304 32407569
Raynaud's phenomenon 11.18 11.04 6 37647 308 32475565
Blood pressure immeasurable 11.08 11.04 9 37644 934 32474939

Pharmacologic Action:

SourceCodeDescription
ATC C07AA05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
ATC C07BA05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, non-selective, and thiazides
ATC C07FX01 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35474 minor tranquilisers
CHEBI has role CHEBI:35530 beta-adrenoceptor antagonists
CHEBI has role CHEBI:35620 vasodilator
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:85234 human blood serum metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Supraventricular tachycardia indication 6456007
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Angina pectoris indication 194828000
Hypertrophic cardiomyopathy indication 233873004 DOID:11984
Idiopathic hypertrophic subaortic stenosis indication 360465008
Hemangioma indication 400210000 DOID:255
Essential tremor indication 609558009 DOID:4990
Arrhythmias During Surgery indication
Migraine Prevention indication
Life-Threatening Ventricular Tachycardia indication
Myocardial Reinfarction Prevention indication
Pheochromocytoma Adjunct Therapy indication
Thyrotoxicosis off-label use 90739004 DOID:7997
Mitral valve prolapse off-label use 409712001
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Prevention of Bleeding Esophageal Varices off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Chronic bronchitis contraindication 63480004 DOID:6132
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of muscle contraindication 129565002 DOID:423
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
4.28MG/ML HEMANGEOL PIERRE FABRE DERMA N205410 March 14, 2014 RX SOLUTION ORAL 8338489 Oct. 16, 2028 METHOD TO TREAT HEMANGIOMA.
4.28MG/ML HEMANGEOL PIERRE FABRE DERMA N205410 March 14, 2014 RX SOLUTION ORAL 8987262 Oct. 16, 2028 METHOD TO TREAT INFANTILE HEMANGIOMA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 8.71 WOMBAT-PK DRUG LABEL
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 8.25 WOMBAT-PK DRUG LABEL
Sodium-dependent serotonin transporter Transporter Ki 6.70 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 6.91 PDSP
5-hydroxytryptamine receptor 2A GPCR Ki 5.38 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 6.66 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.92 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 DRUG MATRIX
Histamine H1 receptor GPCR Ki 4.70 WOMBAT-PK
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 6.22 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 6.20 PDSP
5-hydroxytryptamine receptor 1D GPCR Ki 5.35 PDSP
Cytochrome P450 2D6 Enzyme IC50 5.70 DRUG MATRIX
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 4.32 WOMBAT-PK
Cytochrome P450 1A2 Enzyme IC50 5.40 DRUG MATRIX
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.92 DRUG MATRIX
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 4.30 WOMBAT-PK
Solute carrier family 22 member 1 Transporter IC50 4.20 CHEMBL
Multidrug resistance protein 1 Transporter Ki 4.32 CHEMBL
5-hydroxytryptamine receptor 1B GPCR Ki 7.30 CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.67 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 4.89 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.05 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 9.01 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 9.05 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 8.52 CHEMBL
Beta-2 adrenergic receptor GPCR IC50 7.77 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 8.76 CHEMBL
Adrenergic receptor beta GPCR Ki 8.62 CHEMBL
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 6.60 IUPHAR
Beta-1 adrenergic receptor GPCR Ki 8.62 CHEMBL

External reference:

IDSource
4019916 VUID
N0000148001 NUI
D00483 KEGG_DRUG
318-98-9 SECONDARY_CAS_RN
4017831 VANDF
4019916 VANDF
C0033497 UMLSCUI
CHEBI:8499 CHEBI
CHEMBL27 ChEMBL_ID
CHEMBL1671 ChEMBL_ID
DB00571 DRUGBANK_ID
D011433 MESH_DESCRIPTOR_UI
1940 INN_ID
4946 PUBCHEM_CID
564 IUPHAR_LIGAND_ID
9Y8NXQ24VQ UNII
82084 RXNORM
2240 MMSL
5375 MMSL
d00032 MMSL
001850 NDDF
004740 NDDF
372772003 SNOMEDCT_US
55745002 SNOMEDCT_US
65088001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3727 SOLUTION 20 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3730 SOLUTION 40 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1659 TABLET 10 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1660 TABLET 20 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1661 TABLET 40 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1662 TABLET 80 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1693 TABLET 60 mg ORAL ANDA 19 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0908 SOLUTION 20 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9872 INJECTION 1 mg INTRAVENOUS ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2778 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2779 CAPSULE, EXTENDED RELEASE 80 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2780 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2781 CAPSULE, EXTENDED RELEASE 160 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0182 TABLET 10 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0183 TABLET 20 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0184 TABLET 40 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0185 TABLET 80 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0187 TABLET 60 mg ORAL ANDA 23 sections
PROPRANOLOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9944 INJECTION 1 mg INTRAVENOUS ANDA 12 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4116 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4117 CAPSULE, EXTENDED RELEASE 80 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4118 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4119 CAPSULE, EXTENDED RELEASE 160 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5554 TABLET 10 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5555 TABLET 20 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5556 TABLET 40 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5557 TABLET 80 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-5482 TABLET 10 mg ORAL ANDA 26 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-5483 TABLET 20 mg ORAL ANDA 26 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-5484 TABLET 40 mg ORAL ANDA 26 sections