propranolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 2303 525-66-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propranolol
  • betalong
  • DL-Propranolol
  • racemic propranolol
  • beta-Propranolol
  • propranolol hydrochloride
  • hemangiol
  • propranolol HCl
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
  • Molecular weight: 259.35
  • Formula: C16H21NO2
  • CLOGP: 2.75
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.49
  • ALOGS: -3.51
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.16 g O
0.16 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 35.25 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 26 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 13, 1967 FDA BAXTER HLTHCARE CORP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 691.25 9.98 828 61068 131061 50412167
Product administered to patient of inappropriate age 456.80 9.98 157 61739 2473 50540755
Toxicity to various agents 371.95 9.98 809 61087 211690 50331538
Bradycardia 337.63 9.98 405 61491 64021 50479207
Cardiac arrest 263.60 9.98 411 61485 83240 50459988
Overdose 180.06 9.98 385 61511 99342 50443886
Hypotension 158.44 9.98 638 61258 234831 50308397
Coma 146.08 9.98 255 61641 56624 50486604
Ulcerated haemangioma 142.69 9.98 25 61871 0 50543228
Drug interaction 133.49 9.98 540 61356 199081 50344147
Intentional overdose 122.90 9.98 250 61646 62254 50480974
Joint swelling 118.70 9.98 77 61819 245209 50298019
Cardio-respiratory arrest 114.91 9.98 223 61673 53669 50489559
Electrocardiogram QRS complex prolonged 114.58 9.98 75 61821 5269 50537959
Rheumatoid arthritis 111.78 9.98 54 61842 202496 50340732
Synovitis 109.23 9.98 12 61884 123853 50419375
Respiratory arrest 108.00 9.98 157 61739 29852 50513376
Hand deformity 104.98 9.98 4 61892 100195 50443033
Systemic lupus erythematosus 102.90 9.98 23 61873 140599 50402629
Glossodynia 102.41 9.98 11 61885 115558 50427670
Wound 99.25 9.98 8 61888 105786 50437442
Drug ineffective for unapproved indication 97.25 9.98 125 61771 21156 50522072
Electrocardiogram QT prolonged 93.19 9.98 200 61696 51686 50491542
Seizure 89.39 9.98 332 61564 117542 50425686
Hypoglycaemia 84.40 9.98 196 61700 53385 50489843
Suicidal ideation 83.32 9.98 199 61697 55186 50488042
Cardiogenic shock 81.49 9.98 98 61798 15501 50527727
Sinus bradycardia 80.92 9.98 90 61806 13093 50530135
Arthropathy 79.89 9.98 47 61849 157859 50385369
Infusion related reaction 79.58 9.98 55 61841 169502 50373726
Circulatory collapse 78.39 9.98 109 61787 19891 50523337
Contraindicated product administered 77.26 9.98 43 61853 148915 50394313
Peripheral coldness 76.95 9.98 78 61818 10205 50533023
Pulseless electrical activity 76.65 9.98 65 61831 6776 50536452
Brain injury 75.42 9.98 61 61835 5953 50537275
Pericarditis 73.66 9.98 6 61890 78683 50464545
Neovascularisation 73.29 9.98 32 61864 981 50542247
Suicide attempt 71.57 9.98 180 61716 51552 50491676
Arthralgia 71.14 9.98 286 61610 438416 50104812
Paradoxical drug reaction 70.52 9.98 48 61848 3599 50539629
Infantile spitting up 70.23 9.98 16 61880 44 50543184
Sleep terror 69.63 9.98 28 61868 695 50542533
Swelling 69.62 9.98 86 61810 200786 50342442
Thyrotoxic crisis 68.57 9.98 28 61868 724 50542504
Peripheral swelling 67.43 9.98 92 61804 205844 50337384
Migraine 66.47 9.98 223 61673 75057 50468171
Nightmare 65.04 9.98 89 61807 15997 50527231
Alopecia 63.91 9.98 127 61769 244920 50298308
Drug withdrawal syndrome 63.77 9.98 112 61784 24969 50518259
Extrapyramidal disorder 63.22 9.98 75 61821 11695 50531533
Phaeochromocytoma 62.52 9.98 23 61873 445 50542783
Lower respiratory tract infection 61.28 9.98 20 61876 95181 50448047
Hepatic enzyme increased 61.27 9.98 47 61849 137333 50405895
Anuria 57.69 9.98 70 61826 11174 50532054
Respiratory depression 57.16 9.98 72 61824 11938 50531290
Abdominal discomfort 56.24 9.98 125 61771 231516 50311712
Infection 55.87 9.98 78 61818 172876 50370352
Pain 54.17 9.98 451 61445 578452 49964776
Retinal detachment 51.93 9.98 46 61850 5083 50538145
Therapeutic product effect decreased 51.73 9.98 54 61842 135996 50407232
Tremor 51.64 9.98 277 61619 114626 50428602
Poisoning deliberate 50.26 9.98 55 61841 7857 50535371
Helicobacter infection 48.79 9.98 3 61893 49699 50493529
Somnolence 48.38 9.98 340 61556 154645 50388583
Hepatic encephalopathy 47.83 9.98 59 61837 9577 50533651
Brain death 47.66 9.98 34 61862 2749 50540479
Hyperthyroidism 45.70 9.98 65 61831 12110 50531118
Hypoglycaemic seizure 44.76 9.98 18 61878 447 50542781
Depression 43.77 9.98 349 61547 165074 50378154
Rash 43.53 9.98 335 61561 437136 50106092
Metabolic acidosis 43.52 9.98 125 61771 38700 50504528
Depressed level of consciousness 43.30 9.98 151 61745 51802 50491426
Hyperhidrosis 42.52 9.98 219 61677 89207 50454021
Stomatitis 42.28 9.98 37 61859 101307 50441921
Galactorrhoea 40.94 9.98 35 61861 3688 50539540
Nasopharyngitis 40.63 9.98 112 61784 192815 50350413
Disturbance in attention 40.52 9.98 106 61790 31080 50512148
Shock 39.85 9.98 82 61814 20568 50522660
Electrocardiogram QRS complex shortened 39.03 9.98 16 61880 418 50542810
Panic attack 38.74 9.98 78 61818 19264 50523964
Somatic delusion 38.11 9.98 17 61879 549 50542679
Pneumonia 37.50 9.98 290 61606 378111 50165117
Insulin autoimmune syndrome 36.62 9.98 10 61886 68 50543160
Impaired healing 36.37 9.98 20 61876 69766 50473462
Sinusitis 35.92 9.98 99 61797 170459 50372769
Discomfort 35.86 9.98 48 61848 108332 50434896
Atrioventricular block first degree 35.78 9.98 41 61855 6160 50537068
Maternal exposure during pregnancy 34.96 9.98 91 61805 159687 50383541
Rheumatoid factor positive 34.79 9.98 9 61887 49850 50493378
Disease progression 34.29 9.98 40 61856 95826 50447402
Loss of consciousness 33.76 9.98 231 61665 104122 50439106
Foetal alcohol syndrome 33.76 9.98 7 61889 10 50543218
Inappropriate schedule of product administration 32.82 9.98 174 61722 71657 50471571
Hallucination, auditory 32.74 9.98 52 61844 10676 50532552
Atrioventricular block 32.69 9.98 40 61856 6438 50536790
Musculoskeletal stiffness 32.25 9.98 68 61828 128413 50414815
Fatigue 31.82 9.98 643 61253 706958 49836270
Generalised tonic-clonic seizure 31.73 9.98 87 61809 26223 50517005
Agitation 31.36 9.98 139 61757 53245 50489983
Eosinophilic myocarditis 31.28 9.98 13 61883 352 50542876
Dizziness 30.98 9.98 595 61301 345774 50197454
Hypersensitivity 30.67 9.98 147 61749 215014 50328214
Suspected suicide 30.20 9.98 35 61861 5322 50537906
Pain in extremity 29.46 9.98 204 61692 272661 50270567
Product use in unapproved indication 29.33 9.98 242 61654 115577 50427651
Serotonin syndrome 29.09 9.98 81 61815 24632 50518596
Vision blurred 29.04 9.98 180 61716 78467 50464761
Negative symptoms in schizophrenia 28.88 9.98 9 61887 102 50543126
Hyperammonaemic encephalopathy 28.78 9.98 22 61874 1977 50541251
Hyperthermia 28.75 9.98 41 61855 7655 50535573
Irritability 28.51 9.98 88 61808 28338 50514890
Anxiety 28.33 9.98 337 61559 177269 50365959
Pyrexia 27.91 9.98 314 61582 379889 50163339
Hallucination 27.80 9.98 122 61774 46535 50496693
Mydriasis 27.72 9.98 48 61848 10579 50532649
Palpitations 27.54 9.98 204 61692 94302 50448926
Vascular malformation 26.67 9.98 11 61885 292 50542936
Akathisia 26.66 9.98 41 61855 8188 50535040
Hepatocellular carcinoma 26.61 9.98 21 61875 1978 50541250
Lip swelling 26.14 9.98 78 61818 24658 50518570
Blister 26.11 9.98 40 61856 85378 50457850
Infusion site streaking 25.69 9.98 12 61884 432 50542796
Sleep disorder due to general medical condition, insomnia type 25.42 9.98 4 61892 31443 50511785
Derailment 25.21 9.98 7 61889 51 50543177
Hyperreflexia 24.86 9.98 31 61865 5087 50538141
Accessory cardiac pathway 24.60 9.98 5 61891 6 50543222
Neuropathy peripheral 24.45 9.98 51 61845 96706 50446522
Hyperprolactinaemia 24.22 9.98 25 61871 3340 50539888
Ear infection 23.85 9.98 78 61818 25892 50517336
Hypothermia 23.52 9.98 48 61848 11968 50531260
Paranasal cyst 23.48 9.98 10 61886 288 50542940
Coma scale abnormal 23.34 9.98 29 61867 4742 50538486
Cyanosis 23.30 9.98 55 61841 15129 50528099
Death 22.97 9.98 271 61625 325108 50218120
Interstitial lung disease 22.68 9.98 19 61877 53157 50490071
Dystonia 22.59 9.98 47 61849 11879 50531349
Varices oesophageal 22.42 9.98 22 61874 2767 50540461
Hallucination, visual 22.19 9.98 57 61839 16525 50526703
Migraine with aura 22.16 9.98 20 61876 2265 50540963
Withdrawal syndrome 22.05 9.98 59 61837 17531 50525697
Off label use 21.91 9.98 746 61150 473680 50069548
Haemoglobin decreased 21.77 9.98 81 61815 127135 50416093
Chemical burn 21.64 9.98 10 61886 351 50542877
Narrow anterior chamber angle 21.46 9.98 6 61890 45 50543183
Gastrointestinal disorder 21.26 9.98 53 61843 94403 50448825
Muscle contractions involuntary 20.99 9.98 18 61878 1904 50541324
Herpes zoster 20.82 9.98 34 61862 70752 50472476
Urine amphetamine positive 20.60 9.98 6 61890 53 50543175
Adrenal suppression 20.57 9.98 13 61883 859 50542369
Distractibility 20.50 9.98 10 61886 397 50542831
Retroperitoneal fibrosis 20.37 9.98 9 61887 284 50542944
Poisoning 20.14 9.98 46 61850 12383 50530845
Pituitary apoplexy 20.09 9.98 7 61889 115 50543113
Drug ineffective 20.03 9.98 810 61086 818523 49724705
Acquired porphyria 19.95 9.98 5 61891 23 50543205
Porphyrins urine increased 19.95 9.98 5 61891 23 50543205
Cholestasis of pregnancy 19.79 9.98 14 61882 1117 50542111
Therapeutic product ineffective for unapproved indication 19.69 9.98 8 61888 204 50543024
Hypermobility syndrome 19.67 9.98 12 61884 745 50542483
Panic reaction 19.59 9.98 23 61873 3546 50539682
Neutropenia 19.41 9.98 104 61792 147861 50395367
Chromaturia 19.37 9.98 50 61846 14540 50528688
Acute lung injury 19.33 9.98 15 61881 1378 50541850
Ill-defined disorder 19.32 9.98 23 61873 54631 50488597
Ventricular arrhythmia 19.30 9.98 22 61874 3287 50539941
Knee arthroplasty 19.07 9.98 10 61886 35836 50507392
Porphyrins stool increased 18.85 9.98 5 61891 30 50543198
Productive cough 18.82 9.98 22 61874 52672 50490556
Oesophageal varices haemorrhage 18.60 9.98 13 61883 1017 50542211
Laryngeal dyspnoea 18.50 9.98 7 61889 147 50543081
Mood swings 18.49 9.98 52 61844 15902 50527326
Gynaecomastia 18.28 9.98 7 61889 152 50543076
Lethargy 18.15 9.98 113 61783 49319 50493909
Pleural effusion 18.10 9.98 46 61850 81408 50461820
Poor quality sleep 18.08 9.98 53 61843 16593 50526635
Accelerated idioventricular rhythm 18.06 9.98 5 61891 36 50543192
Perseveration 18.03 9.98 8 61888 255 50542973
Apraxia 17.97 9.98 15 61881 1530 50541698
Therapeutic product effective for unapproved indication 17.84 9.98 6 61890 88 50543140
C-reactive protein increased 17.68 9.98 34 61862 66440 50476788
Haematemesis 17.67 9.98 74 61822 27651 50515577
Bezoar 17.60 9.98 14 61882 1334 50541894
Paraganglion neoplasm 17.56 9.98 4 61892 11 50543217
Mental disorder 17.53 9.98 63 61833 21928 50521300
Vertigo 17.50 9.98 116 61780 51716 50491512
Febrile neutropenia 17.49 9.98 61 61835 97606 50445622
Hyponatraemic seizure 17.37 9.98 9 61887 407 50542821
Thyrotoxic cardiomyopathy 17.12 9.98 3 61893 0 50543228
Mobility decreased 17.12 9.98 46 61850 79902 50463326
Blood prolactin increased 17.06 9.98 20 61876 3079 50540149
Defect conduction intraventricular 16.87 9.98 6 61890 105 50543123
Haemodynamic instability 16.84 9.98 33 61863 7991 50535237
Ventricular tachycardia 16.82 9.98 50 61846 15771 50527457
Tumour rupture 16.82 9.98 6 61890 106 50543122
Cerebral vasoconstriction 16.71 9.98 12 61884 980 50542248
Psychotic symptom 16.71 9.98 13 61883 1199 50542029
Tardive dyskinesia 16.58 9.98 31 61865 7248 50535980
Jaundice 16.42 9.98 70 61826 26359 50516869
Sleep disorder 16.31 9.98 123 61773 57160 50486068
Hepatic steatosis 16.26 9.98 66 61830 24318 50518910
Teething 16.22 9.98 4 61892 17 50543211
Confusional state 16.10 9.98 318 61578 185610 50357618
Cerebellar syndrome 15.99 9.98 20 61876 3291 50539937
Altered state of consciousness 15.98 9.98 61 61835 21849 50521379
Unresponsive to stimuli 15.98 9.98 77 61819 30532 50512696
Intentional self-injury 15.77 9.98 63 61833 23049 50520179
Agoraphobia 15.70 9.98 8 61888 349 50542879
Exposure via transplant 15.69 9.98 4 61892 20 50543208
Hip arthroplasty 15.45 9.98 9 61887 30420 50512808
Feeling abnormal 15.36 9.98 227 61669 125265 50417963
Thyroxine free decreased 15.36 9.98 9 61887 519 50542709
Feeling guilty 15.33 9.98 9 61887 521 50542707
Depressed mood 15.25 9.98 82 61814 33941 50509287
Urinary tract infection 15.24 9.98 188 61708 223832 50319396
Somnambulism 15.21 9.98 24 61872 4900 50538328
Intentional product use issue 15.19 9.98 46 61850 76872 50466356
Torsade de pointes 15.14 9.98 40 61856 11795 50531433
Bradycardia foetal 15.02 9.98 8 61888 383 50542845
Breath holding 14.99 9.98 6 61890 147 50543081
Salivary hypersecretion 14.93 9.98 28 61868 6563 50536665
Irritable bowel syndrome 14.86 9.98 25 61871 51416 50491812
Food craving 14.76 9.98 13 61883 1426 50541802
Dissociation 14.68 9.98 16 61880 2275 50540953
Drug intolerance 14.49 9.98 185 61711 218919 50324309
Pulse absent 14.26 9.98 23 61873 4783 50538445
Memory impairment 14.17 9.98 154 61742 79206 50464022
Monoclonal gammopathy 14.12 9.98 9 61887 604 50542624
Myocardial depression 13.96 9.98 8 61888 442 50542786
Gastrointestinal motility disorder 13.96 9.98 22 61874 4487 50538741
Product complaint 13.91 9.98 38 61858 11428 50531800
Congenital pharyngeal anomaly 13.83 9.98 3 61893 6 50543222
Treatment failure 13.81 9.98 105 61791 137532 50405696
Mastoiditis 13.81 9.98 10 61886 828 50542400
Alcohol interaction 13.78 9.98 15 61881 2129 50541099
Sinus rhythm 13.76 9.98 9 61887 631 50542597
Heart rate decreased 13.76 9.98 84 61812 36413 50506815
Abnormal faeces 13.72 9.98 21 61875 4175 50539053
Dermatitis diaper 13.71 9.98 6 61890 185 50543043
Exposure via ingestion 13.65 9.98 17 61879 2786 50540442
Hypoperfusion 13.61 9.98 12 61884 1318 50541910
Drug dependence 13.59 9.98 54 61842 19705 50523523
Abnormal dreams 13.35 9.98 33 61863 9344 50533884
Nervousness 13.32 9.98 68 61828 27583 50515645
Self-injurious ideation 13.30 9.98 15 61881 2214 50541014
Aggression 13.17 9.98 56 61840 21060 50522168
Pruritus 13.16 9.98 256 61640 283312 50259916
Tonic convulsion 13.12 9.98 11 61885 1128 50542100
Basilar migraine 13.11 9.98 4 61892 42 50543186
Antipsychotic drug level decreased 13.06 9.98 6 61890 208 50543020
Cough 13.04 9.98 212 61684 241052 50302176
Blood lactic acid increased 12.99 9.98 24 61872 5561 50537667
Aphasia 12.99 9.98 69 61827 28425 50514803
Disorientation 12.95 9.98 81 61815 35403 50507825
Dyspnoea exertional 12.94 9.98 27 61869 51206 50492022
Oculogyric crisis 12.81 9.98 12 61884 1425 50541803
Agranulocytosis 12.74 9.98 56 61840 21365 50521863
Drug level increased 12.73 9.98 52 61844 19216 50524012
Cognitive disorder 12.70 9.98 95 61801 44028 50499200
Ventricular failure 12.66 9.98 7 61889 361 50542867
Thyroid cancer metastatic 12.59 9.98 5 61891 120 50543108
Stress ulcer 12.55 9.98 4 61892 49 50543179
Tri-iodothyronine decreased 12.51 9.98 5 61891 122 50543106
Behaviour disorder 12.51 9.98 15 61881 2365 50540863
Alveolar bone resorption 12.41 9.98 4 61892 51 50543177
Conjunctival hyperaemia 12.41 9.98 14 61882 2068 50541160
Aspiration of gastric residual 12.31 9.98 3 61893 12 50543216
Poor feeding infant 12.30 9.98 6 61890 238 50542990
Atrophy 12.22 9.98 12 61884 1511 50541717
Therapeutic product effect incomplete 12.18 9.98 64 61832 91451 50451777
Bundle branch block right 12.14 9.98 21 61875 4624 50538604
Ear discomfort 12.10 9.98 26 61870 6718 50536510
Septic arthritis staphylococcal 11.97 9.98 7 61889 402 50542826
Palmar erythema 11.96 9.98 12 61884 1551 50541677
Diplopia 11.96 9.98 51 61845 19209 50524019
Thyroxine free increased 11.94 9.98 9 61887 792 50542436
Malignant neoplasm progression 11.89 9.98 43 61853 68081 50475147
Inappropriate affect 11.88 9.98 9 61887 798 50542430
Bundle branch block 11.83 9.98 9 61887 803 50542425
Nodal rhythm 11.80 9.98 12 61884 1575 50541653
Oedema peripheral 11.73 9.98 130 61766 157831 50385397
Actinic keratosis 11.64 9.98 14 61882 2213 50541015
Metastases to liver 11.63 9.98 5 61891 20099 50523129
Change in seizure presentation 11.60 9.98 6 61890 270 50542958
Oromandibular dystonia 11.50 9.98 7 61889 433 50542795
Multiple lentigines syndrome 11.46 9.98 5 61891 153 50543075
Thalamic infarction 11.40 9.98 7 61889 440 50542788
Tongue pruritus 11.38 9.98 7 61889 441 50542787
Muscle rigidity 11.35 9.98 32 61864 9797 50533431
Blood pressure systolic decreased 11.32 9.98 23 61873 5716 50537512
Broad ligament tear 11.31 9.98 3 61893 18 50543210
Haemorrhagic tumour necrosis 11.31 9.98 3 61893 18 50543210
Muscle twitching 11.29 9.98 43 61853 15388 50527840
Postural orthostatic tachycardia syndrome 11.26 9.98 9 61887 863 50542365
Porphyria non-acute 11.19 9.98 6 61890 291 50542937
Suicidal behaviour 11.12 9.98 14 61882 2320 50540908
Transposition of the great vessels 11.11 9.98 5 61891 165 50543063
Essential tremor 11.09 9.98 9 61887 882 50542346
Epilepsy 11.07 9.98 54 61842 21513 50521715
Psychomotor retardation 11.03 9.98 17 61879 3401 50539827
Phonophobia 10.97 9.98 6 61890 303 50542925
Rhythm idioventricular 10.92 9.98 5 61891 172 50543056
Respiratory tract infection 10.77 9.98 14 61882 32003 50511225
Psychotic disorder 10.76 9.98 54 61842 21758 50521470
Cutaneous lupus erythematosus 10.67 9.98 14 61882 2417 50540811
Wound infection bacterial 10.60 9.98 7 61889 499 50542729
Tic 10.54 9.98 10 61886 1207 50542021
Duodenal perforation 10.52 9.98 8 61888 713 50542515
Breast cancer 10.50 9.98 23 61873 42867 50500361
Electrocardiogram QT interval 10.40 9.98 4 61892 88 50543140
Choanal atresia 10.35 9.98 3 61893 26 50543202
Pupil fixed 10.23 9.98 11 61885 1541 50541687
Hypertensive emergency 10.16 9.98 11 61885 1552 50541676
Osteonecrosis of external auditory canal 10.11 9.98 4 61892 95 50543133
Back pain 10.09 9.98 199 61697 219831 50323397
Tearfulness 10.07 9.98 17 61879 3670 50539558
Sudden infant death syndrome 10.06 9.98 5 61891 207 50543021
Sinoatrial block 10.01 9.98 8 61888 767 50542461

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 265.67 11.22 418 34018 89828 29450263
Bradycardia 211.26 11.22 317 34119 65312 29474779
Hepatic encephalopathy 179.82 11.22 137 34299 12898 29527193
Product administered to patient of inappropriate age 176.96 11.22 78 34358 2577 29537514
Toxicity to various agents 166.34 11.22 511 33925 173150 29366941
Cardiac arrest 100.18 11.22 271 34165 85320 29454771
Ascites 84.02 11.22 152 34284 36467 29503624
Oesophageal varices haemorrhage 83.26 11.22 47 34389 2655 29537436
Hepatocellular carcinoma 77.85 11.22 65 34371 6973 29533118
Parasomnia 77.03 11.22 25 34411 344 29539747
Hyperthyroidism 76.13 11.22 70 34366 8538 29531553
Intentional overdose 76.08 11.22 150 34286 38378 29501713
Myokymia 64.21 11.22 16 34420 76 29540015
Varices oesophageal 61.71 11.22 41 34395 3105 29536986
Akathisia 59.96 11.22 55 34381 6687 29533404
Encapsulating peritoneal sclerosis 58.79 11.22 23 34413 558 29539533
Drug interaction 58.21 11.22 411 34025 196974 29343117
Febrile neutropenia 55.23 11.22 31 34405 112209 29427882
Hepatic cirrhosis 53.99 11.22 75 34361 14369 29525722
Nightmare 53.09 11.22 66 34370 11351 29528740
Pneumonia 52.55 11.22 194 34242 319978 29220113
Areflexia 51.88 11.22 35 34401 2719 29537372
Cerebral artery thrombosis 50.09 11.22 22 34414 720 29539371
Hepatorenal syndrome 50.00 11.22 32 34404 2274 29537817
Overdose 49.50 11.22 204 34232 79615 29460476
Brain scan abnormal 47.23 11.22 22 34414 828 29539263
Sedation 40.86 11.22 73 34363 17332 29522759
Poisoning deliberate 40.13 11.22 41 34395 5690 29534401
Cardiogenic shock 39.42 11.22 76 34360 19114 29520977
Hyperhidrosis 39.25 11.22 164 34272 64376 29475715
Granulomatous rosacea 39.01 11.22 12 34424 137 29539954
Cardio-respiratory arrest 38.46 11.22 138 34298 50463 29489628
Foetal disorder 36.61 11.22 18 34418 765 29539326
Respiratory arrest 35.53 11.22 87 34349 25746 29514345
Suicidal ideation 34.76 11.22 104 34332 34612 29505479
Tremor 33.71 11.22 172 34264 73366 29466725
Neutropenia neonatal 33.42 11.22 16 34420 641 29539450
Thyrotoxic periodic paralysis 32.46 11.22 9 34427 69 29540022
Abnormal sleep-related event 32.34 11.22 14 34422 442 29539649
Infantile spitting up 31.77 11.22 8 34428 40 29540051
Disturbance in attention 31.45 11.22 74 34362 21350 29518741
Sinus bradycardia 30.28 11.22 51 34385 11552 29528539
Premature baby 30.21 11.22 64 34372 17216 29522875
Granulocytopenia 30.05 11.22 36 34400 5958 29534133
Photophobia 30.05 11.22 36 34400 5959 29534132
Suicidal behaviour 29.74 11.22 19 34417 1346 29538745
Encephalopathy 29.21 11.22 91 34345 30952 29509139
Dyspnoea 27.89 11.22 245 34191 326487 29213604
Phaeochromocytoma malignant 27.72 11.22 8 34428 72 29540019
Somnolence 27.22 11.22 195 34241 93760 29446331
Hepatitis C 27.12 11.22 42 34394 8868 29531223
Psychotic disorder 26.36 11.22 67 34369 20287 29519804
Drug withdrawal syndrome 26.26 11.22 62 34374 17922 29522169
Neutrophil count decreased 26.19 11.22 9 34427 43558 29496533
Gastroenteritis eosinophilic 25.92 11.22 9 34427 154 29539937
Platelet count decreased 24.81 11.22 53 34383 104619 29435472
Product use issue 24.74 11.22 122 34314 51322 29488769
Portal hypertensive gastropathy 24.56 11.22 12 34424 503 29539588
Peripheral coldness 24.23 11.22 33 34403 6203 29533888
Irritability 23.74 11.22 68 34368 22084 29518007
Aggression 23.73 11.22 93 34343 35448 29504643
Myocardial infarction 23.61 11.22 59 34377 110237 29429854
Malignant neoplasm progression 23.41 11.22 31 34405 73828 29466263
Acute stress disorder 22.93 11.22 8 34428 139 29539952
Anxiety 22.35 11.22 173 34263 85192 29454899
Alcoholism 22.29 11.22 21 34415 2640 29537451
Tardive dyskinesia 22.24 11.22 29 34407 5229 29534862
Hallucination, auditory 22.21 11.22 40 34396 9553 29530538
Pulseless electrical activity 21.96 11.22 32 34404 6402 29533689
Portal vein thrombosis 21.95 11.22 23 34413 3286 29536805
Hepatitis C RNA positive 21.75 11.22 8 34428 163 29539928
Genotype drug resistance test positive 21.69 11.22 14 34422 1009 29539082
White blood cell count decreased 21.65 11.22 40 34396 83322 29456769
Hepatopulmonary syndrome 21.40 11.22 5 34431 17 29540074
Low birth weight baby 21.31 11.22 32 34404 6576 29533515
Myocardial depression 21.20 11.22 6 34430 50 29540041
Sexually inappropriate behaviour 21.09 11.22 10 34426 392 29539699
Lethargy 20.91 11.22 93 34343 37487 29502604
Hepatic cancer 20.45 11.22 31 34405 6425 29533666
Hypoaesthesia eye 20.20 11.22 5 34431 23 29540068
Sleep disorder 19.80 11.22 68 34368 24318 29515773
Insomnia 19.54 11.22 173 34263 88588 29451503
Withdrawal syndrome 19.54 11.22 41 34395 10951 29529140
Disorientation 19.51 11.22 77 34359 29438 29510653
Product use in unapproved indication 19.48 11.22 170 34266 86705 29453386
Agitation 19.45 11.22 114 34322 51190 29488901
Hypotension 19.45 11.22 326 34110 194028 29346063
Nephrolithiasis 19.16 11.22 69 34367 25265 29514826
Thyrotoxic crisis 19.04 11.22 9 34427 350 29539741
Disease progression 18.97 11.22 42 34394 81874 29458217
Antipsychotic drug level increased 18.81 11.22 21 34415 3222 29536869
Interstitial lung disease 18.52 11.22 24 34412 57694 29482397
Electrocardiogram QRS complex shortened 18.45 11.22 7 34429 156 29539935
Meningitis streptococcal 18.43 11.22 5 34431 35 29540056
Torsade de pointes 18.35 11.22 30 34406 6631 29533460
Phaeochromocytoma 18.20 11.22 7 34429 162 29539929
Cardiac failure congestive 17.95 11.22 39 34397 76542 29463549
Phonophobia 17.92 11.22 7 34429 169 29539922
Suicide attempt 17.92 11.22 83 34353 34027 29506064
Coma 17.87 11.22 92 34344 39358 29500733
Tinnitus 17.78 11.22 49 34387 15565 29524526
Sepsis 17.56 11.22 96 34340 142586 29397505
Hepatic failure 17.54 11.22 78 34358 31434 29508657
Ventricular arrhythmia 17.34 11.22 24 34412 4580 29535511
Lupus-like syndrome 17.34 11.22 17 34419 2245 29537846
Social avoidant behaviour 16.98 11.22 19 34417 2923 29537168
Pseudoporphyria 16.84 11.22 8 34428 315 29539776
Seizure 16.79 11.22 174 34262 92949 29447142
Depression 16.75 11.22 162 34274 84985 29455106
Differential white blood cell count abnormal 16.75 11.22 13 34423 1256 29538835
Rash 16.74 11.22 141 34295 189678 29350413
Intentional product misuse 16.52 11.22 82 34354 34579 29505512
Binocular eye movement disorder 16.51 11.22 5 34431 54 29540037
Biliary anastomosis 16.23 11.22 4 34432 18 29540073
Death 16.13 11.22 291 34145 341793 29198298
Atrioventricular block first degree 16.08 11.22 25 34411 5294 29534797
Stomatitis 15.85 11.22 12 34424 37101 29502990
Reversible airways obstruction 15.53 11.22 7 34429 244 29539847
Poor quality sleep 15.29 11.22 29 34407 7204 29532887
Alcoholic liver disease 15.28 11.22 9 34427 551 29539540
Peritoneal fibrosis 15.19 11.22 3 34433 3 29540088
Renal hamartoma 15.19 11.22 3 34433 3 29540088
Ammonia increased 15.16 11.22 21 34415 4010 29536081
Genital swelling 15.06 11.22 6 34430 153 29539938
Patient dissatisfaction with treatment 14.95 11.22 5 34431 76 29540015
Neutropenia 14.92 11.22 91 34345 131620 29408471
Withdrawal hypertension 14.91 11.22 6 34430 157 29539934
Oesophageal variceal ligation 14.83 11.22 5 34431 78 29540013
Alcohol interaction 14.82 11.22 17 34419 2686 29537405
Restlessness 14.82 11.22 58 34378 22087 29518004
Joint swelling 14.56 11.22 22 34414 49608 29490483
Sleep deficit 14.43 11.22 8 34428 436 29539655
Persecutory delusion 14.41 11.22 15 34421 2126 29537965
Neuropathy peripheral 14.41 11.22 39 34397 70988 29469103
Portal hypertension 14.39 11.22 19 34417 3467 29536624
Negative thoughts 14.34 11.22 9 34427 618 29539473
Hallucination 14.23 11.22 95 34341 44617 29495474
Reflux gastritis 14.22 11.22 7 34429 298 29539793
Pruritus 14.16 11.22 79 34357 116770 29423321
Renal impairment 14.12 11.22 48 34388 81285 29458806
Cryoglobulinaemia 14.03 11.22 7 34429 307 29539784
Laryngeal erythema 13.98 11.22 3 34433 6 29540085
Micrographia 13.98 11.22 3 34433 6 29540085
Psychomotor hyperactivity 13.87 11.22 30 34406 8183 29531908
Wrong strength 13.82 11.22 5 34431 97 29539994
Hypertrophic cardiomyopathy 13.82 11.22 10 34426 869 29539222
Pyrexia 13.76 11.22 244 34192 287378 29252713
Delusion 13.57 11.22 36 34400 11180 29528911
Drooling 13.30 11.22 17 34419 3004 29537087
Stoma site haemorrhage 13.24 11.22 9 34427 708 29539383
Hallucination, visual 13.19 11.22 43 34393 14972 29525119
Product used for unknown indication 13.09 11.22 7 34429 355 29539736
Atrial fibrillation 13.03 11.22 71 34365 105575 29434516
Defect conduction intraventricular 12.87 11.22 6 34430 226 29539865
Thyroxine free increased 12.80 11.22 6 34430 229 29539862
Maternal drugs affecting foetus 12.76 11.22 19 34417 3874 29536217
Pain in extremity 12.66 11.22 76 34360 110357 29429734
Gastric varices 12.64 11.22 7 34429 381 29539710
Product communication issue 12.49 11.22 5 34431 129 29539962
Panic attack 12.48 11.22 29 34407 8297 29531794
Hypnagogic hallucination 12.39 11.22 4 34432 54 29540037
Pain 12.27 11.22 134 34302 171298 29368793
Loss of bladder sensation 12.20 11.22 4 34432 57 29540034
Hemiplegia 12.20 11.22 25 34411 6569 29533522
Peripheral swelling 12.19 11.22 36 34400 63703 29476388
Chronic obstructive pulmonary disease 12.16 11.22 18 34418 40937 29499154
Action tremor 12.13 11.22 4 34432 58 29540033
Right-to-left cardiac shunt 12.13 11.22 4 34432 58 29540033
Depressed level of consciousness 12.06 11.22 79 34357 36863 29503228
Poisoning 12.02 11.22 32 34404 9961 29530130
Dysmorphism 11.97 11.22 16 34420 2955 29537136
Gastric hypomotility 11.95 11.22 4 34432 61 29540030
Blood creatinine increased 11.74 11.22 55 34381 85047 29455044
Secondary hypogonadism 11.68 11.22 6 34430 280 29539811
Contraindication to medical treatment 11.67 11.22 7 34429 443 29539648
Contraindicated product administered 11.55 11.22 47 34389 18219 29521872
Subdural hygroma 11.43 11.22 6 34430 293 29539798
Mucosal inflammation 11.35 11.22 12 34424 31583 29508508
Chronic spontaneous urticaria 11.33 11.22 4 34432 72 29540019
Radicular pain 11.33 11.22 4 34432 72 29540019
Affective disorder 11.33 11.22 16 34420 3110 29536981
Migraine 11.28 11.22 36 34400 12394 29527697

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 970.94 9.99 1284 78154 223130 64196164
Bradycardia 484.78 9.99 660 78778 117559 64301735
Toxicity to various agents 451.47 9.99 1217 78221 362296 64056998
Cardiac arrest 363.93 9.99 668 78770 153396 64265898
Product administered to patient of inappropriate age 321.20 9.99 142 79296 4459 64414835
Overdose 213.34 9.99 550 78888 159016 64260278
Intentional overdose 209.62 9.99 388 79050 89556 64329738
Hepatic encephalopathy 206.48 9.99 186 79252 20880 64398414
Drug interaction 162.56 9.99 876 78562 361207 64058087
Cardio-respiratory arrest 157.90 9.99 364 79074 98029 64321265
Respiratory arrest 152.60 9.99 251 79187 52734 64366560
Hypotension 148.79 9.99 888 78550 380086 64039208
Coma 147.10 9.99 330 79108 87285 64332009
Cardiogenic shock 110.53 9.99 166 79272 32261 64387033
Sinus bradycardia 104.69 9.99 135 79303 22758 64396536
Hepatocellular carcinoma 104.37 9.99 85 79353 8318 64410976
Electrocardiogram QRS complex prolonged 97.30 9.99 85 79353 9159 64410135
Joint swelling 94.49 9.99 76 79362 215306 64203988
Drug ineffective for unapproved indication 94.40 9.99 151 79287 30982 64388312
Hyperthyroidism 89.14 9.99 111 79327 18068 64401226
Suicide attempt 87.87 9.99 238 79200 70769 64348525
Pneumonia 87.21 9.99 374 79064 559202 63860092
Synovitis 87.10 9.99 10 79428 99080 64320214
Poisoning deliberate 85.74 9.99 94 79344 13364 64405930
Nightmare 85.54 9.99 117 79321 20876 64398418
Rheumatoid arthritis 84.01 9.99 49 79389 164245 64255049
Oesophageal varices haemorrhage 82.55 9.99 53 79385 3576 64415718
Thyrotoxic crisis 79.69 9.99 35 79403 1081 64418213
Brain injury 78.55 9.99 78 79360 9887 64409407
Pulseless electrical activity 77.75 9.99 87 79351 12652 64406642
Seizure 77.53 9.99 408 79030 166484 64252810
Hyperhidrosis 72.83 9.99 326 79112 124594 64294700
Parasomnia 72.19 9.99 26 79412 469 64418825
Febrile neutropenia 71.87 9.99 75 79363 187582 64231712
Electrocardiogram QT prolonged 70.63 9.99 237 79201 79211 64340083
Neovascularisation 70.46 9.99 32 79406 1071 64418223
Hypoglycaemia 68.60 9.99 255 79183 89637 64329657
Varices oesophageal 68.19 9.99 54 79384 5076 64414218
Infusion related reaction 67.28 9.99 62 79376 164405 64254889
Arthralgia 66.74 9.99 299 79139 441961 63977333
Circulatory collapse 65.70 9.99 135 79303 33597 64385697
Hand deformity 64.60 9.99 3 79435 62768 64356526
Phaeochromocytoma 64.23 9.99 25 79413 564 64418730
Myokymia 64.10 9.99 17 79421 101 64419193
Suicidal ideation 64.09 9.99 204 79234 66338 64352956
Peripheral swelling 64.09 9.99 99 79339 209054 64210240
Wound 61.81 9.99 10 79428 76467 64342827
Hypoglycaemic seizure 61.11 9.99 26 79412 742 64418552
Akathisia 59.21 9.99 72 79366 11438 64407856
Ascites 58.73 9.99 189 79249 61812 64357482
Disturbance in attention 58.33 9.99 145 79293 40929 64378365
Drug withdrawal syndrome 58.33 9.99 123 79315 31168 64388126
Tremor 57.30 9.99 345 79093 147885 64271409
Migraine 56.61 9.99 188 79250 62489 64356805
Arthropathy 56.46 9.99 40 79398 120927 64298367
Depressed level of consciousness 56.38 9.99 224 79214 81212 64338082
Electrocardiogram QRS complex shortened 55.35 9.99 23 79415 618 64418676
Somnolence 55.00 9.99 434 79004 203211 64216083
Peripheral coldness 54.27 9.99 75 79363 13509 64405785
Pain 49.44 9.99 440 78998 553071 63866223
Extrapyramidal disorder 48.86 9.99 87 79351 19465 64399829
Pericarditis 48.71 9.99 9 79429 62507 64356787
Nasopharyngitis 48.33 9.99 106 79332 195967 64223327
Encapsulating peritoneal sclerosis 46.67 9.99 22 79416 803 64418491
Stomatitis 46.40 9.99 40 79398 109565 64309729
Irritability 46.28 9.99 124 79314 36622 64382672
Lower respiratory tract infection 45.87 9.99 30 79408 94584 64324710
Hallucination, auditory 45.75 9.99 78 79360 16861 64402433
Neuropathy peripheral 44.94 9.99 47 79391 117478 64301816
Hepatorenal syndrome 44.65 9.99 37 79401 3709 64415585
Atrioventricular block first degree 43.99 9.99 60 79378 10674 64408620
Pyrexia 43.16 9.99 460 78978 558184 63861110
Generalised tonic-clonic seizure 41.90 9.99 126 79312 39731 64379563
Hepatic cirrhosis 41.81 9.99 97 79341 26201 64393093
Depression 41.72 9.99 376 79062 182915 64236379
Agitation 41.65 9.99 217 79221 88150 64331144
Disease progression 41.55 9.99 69 79369 141611 64277683
Infection 41.52 9.99 105 79333 184775 64234519
Glossodynia 41.36 9.99 14 79424 64682 64354612
Suicidal behaviour 39.69 9.99 31 79407 2856 64416438
Anuria 39.43 9.99 78 79360 18886 64400408
Paradoxical drug reaction 39.42 9.99 43 79395 6077 64413217
Pain in extremity 39.28 9.99 216 79222 302869 64116425
Infantile spitting up 39.13 9.99 8 79430 10 64419284
Systemic lupus erythematosus 38.45 9.99 24 79414 77588 64341706
Somatic delusion 37.81 9.99 18 79420 672 64418622
Interstitial lung disease 37.46 9.99 39 79399 97693 64321601
Atrioventricular block 37.41 9.99 59 79379 11956 64407338
Areflexia 37.27 9.99 38 79400 4969 64414325
Rash 36.85 9.99 374 79064 458175 63961119
Brain scan abnormal 36.74 9.99 21 79417 1147 64418147
Brain death 36.38 9.99 37 79401 4824 64414470
Swelling 35.97 9.99 91 79347 160127 64259167
Cerebral artery thrombosis 35.91 9.99 20 79418 1039 64418255
Therapeutic product effect decreased 35.88 9.99 54 79384 115297 64303997
Hallucination 35.87 9.99 181 79257 72607 64346687
Shock 35.69 9.99 116 79322 38124 64381170
Hepatic enzyme increased 35.64 9.99 66 79372 129877 64289417
Accessory cardiac pathway 35.58 9.99 7 79431 6 64419288
Product use in unapproved indication 35.55 9.99 353 79085 176265 64243029
Respiratory depression 34.60 9.99 84 79354 23359 64395935
Granulomatous rosacea 34.36 9.99 12 79426 197 64419097
Panic attack 34.10 9.99 78 79360 20875 64398419
Sleep terror 33.63 9.99 20 79418 1177 64418117
Hypermobility syndrome 32.95 9.99 15 79423 505 64418789
Ventricular arrhythmia 32.76 9.99 43 79395 7372 64411922
Galactorrhoea 32.68 9.99 29 79409 3190 64416104
Hallucination, visual 32.14 9.99 91 79347 27743 64391551
Granulocytopenia 32.14 9.99 51 79387 10389 64408905
Serotonin syndrome 32.12 9.99 114 79324 39168 64380126
Suspected suicide 31.93 9.99 46 79392 8608 64410686
Withdrawal syndrome 31.34 9.99 81 79357 23411 64395883
Dyspnoea 31.16 9.99 662 78776 718012 63701282
Herpes zoster 31.03 9.99 31 79407 79156 64340138
Anxiety 30.71 9.99 383 79055 202266 64217028
Myocardial depression 30.27 9.99 14 79424 489 64418805
Alcohol interaction 30.24 9.99 32 79406 4369 64414925
Torsade de pointes 29.78 9.99 66 79372 17297 64401997
Poisoning 29.76 9.99 76 79362 21803 64397491
Thyrotoxic periodic paralysis 29.66 9.99 9 79429 92 64419202
Productive cough 29.44 9.99 28 79410 73175 64346119
Psychotic disorder 28.83 9.99 101 79337 34477 64384817
Neutropenia 28.76 9.99 175 79263 239449 64179845
Loss of consciousness 28.63 9.99 294 79144 148071 64271223
Negative symptoms in schizophrenia 28.13 9.99 9 79429 111 64419183
Haemoglobin decreased 28.08 9.99 134 79304 194929 64224365
Hepatitis C 27.50 9.99 49 79389 10966 64408328
Alopecia 27.40 9.99 108 79330 165582 64253712
Phaeochromocytoma malignant 27.27 9.99 8 79430 72 64419222
Vision blurred 26.88 9.99 197 79241 90119 64329175
Sinusitis 26.84 9.99 91 79347 145837 64273457
Hyperreflexia 26.38 9.99 38 79400 7110 64412184
Lethargy 26.16 9.99 166 79272 72428 64346866
Gastroenteritis eosinophilic 25.76 9.99 10 79428 224 64419070
Impaired healing 25.67 9.99 22 79416 60451 64358843
Palpitations 25.65 9.99 218 79220 104270 64315024
Alcoholism 25.56 9.99 26 79412 3391 64415903
Disorientation 25.55 9.99 136 79302 55692 64363602
Infusion site streaking 25.53 9.99 12 79426 435 64418859
Malignant neoplasm progression 25.41 9.99 64 79374 112807 64306487
Helicobacter infection 25.05 9.99 8 79430 38354 64380940
Bradycardia foetal 24.84 9.99 8 79430 101 64419193
Metabolic acidosis 24.80 9.99 161 79277 70797 64348497
Phonophobia 24.72 9.99 12 79426 468 64418826
Tardive dyskinesia 24.44 9.99 42 79396 9136 64410158
Hypersensitivity 24.34 9.99 142 79296 196310 64222984
Cyanosis 24.20 9.99 71 79367 22084 64397210
Gross motor delay 24.07 9.99 7 79431 61 64419233
Pruritus 23.75 9.99 258 79180 312142 64107152
Portal vein thrombosis 23.71 9.99 30 79408 4961 64414333
Therapeutic product ineffective for unapproved indication 23.57 9.99 8 79430 120 64419174
Confusional state 23.54 9.99 452 78986 260692 64158602
Intentional self-injury 23.49 9.99 84 79354 28960 64390334
Intentional product misuse 23.44 9.99 161 79277 72134 64347160
Eosinophilic myocarditis 23.32 9.99 14 79424 838 64418456
Derailment 23.30 9.99 7 79431 69 64419225
Vascular malformation 23.29 9.99 10 79428 292 64419002
Antipsychotic drug level increased 23.12 9.99 30 79408 5085 64414209
Sepsis 22.80 9.99 178 79260 230163 64189131
Encephalopathy 22.76 9.99 137 79301 58682 64360612
Hypoaesthesia eye 22.44 9.99 7 79431 79 64419215
Aggression 22.10 9.99 114 79324 46118 64373176
Paranasal cyst 22.04 9.99 10 79428 334 64418960
Hyperammonaemic encephalopathy 21.88 9.99 26 79412 4032 64415262
Gastrointestinal disorder 21.67 9.99 49 79389 89660 64329634
Drug withdrawal syndrome neonatal 21.62 9.99 9 79429 243 64419051
Rheumatoid factor positive 21.58 9.99 8 79430 34930 64384364
Chronic obstructive pulmonary disease 21.38 9.99 34 79404 71014 64348280
Abnormal sleep-related event 21.33 9.99 13 79425 800 64418494
Mood swings 21.04 9.99 58 79380 17410 64401884
Poor quality sleep 20.95 9.99 61 79377 18890 64400404
Agranulocytosis 20.94 9.99 98 79340 38131 64381163
Musculoskeletal stiffness 20.56 9.99 80 79358 123126 64296168
Neutrophil count decreased 20.46 9.99 40 79398 77156 64342138
Muscle injury 20.18 9.99 4 79434 26433 64392861
Sleep disorder due to general medical condition, insomnia type 20.00 9.99 4 79434 26266 64393028
Thyroxine free increased 19.97 9.99 14 79424 1093 64418201
Migraine with aura 19.91 9.99 19 79419 2293 64417001
Abdominal discomfort 19.91 9.99 137 79301 182185 64237109
Platelet count decreased 19.84 9.99 123 79315 167588 64251706
Cholestasis of pregnancy 19.79 9.99 13 79425 912 64418382
Muscle contractions involuntary 19.68 9.99 22 79416 3195 64416099
Mydriasis 19.61 9.99 52 79386 15260 64404034
Pupil fixed 19.59 9.99 22 79416 3210 64416084
Depressed mood 19.51 9.99 101 79337 40911 64378383
Cutaneous lupus erythematosus 19.32 9.99 20 79418 2662 64416632
Cytomegalovirus infection 19.13 9.99 11 79427 37188 64382106
Sexually inappropriate behaviour 19.11 9.99 10 79428 458 64418836
Tinnitus 19.06 9.99 88 79350 34045 64385249
Cerebellar syndrome 19.00 9.99 27 79411 4989 64414305
Porphyrins urine increased 18.96 9.99 5 79433 29 64419265
Bezoar 18.78 9.99 18 79420 2185 64417109
Hyperprolactinaemia 18.62 9.99 24 79414 4041 64415253
Urine amphetamine positive 18.61 9.99 6 79432 76 64419218
Hypnagogic hallucination 18.58 9.99 7 79431 144 64419150
Insulin autoimmune syndrome 18.56 9.99 9 79429 350 64418944
Hepatitis C RNA positive 18.55 9.99 8 79430 236 64419058
Thyroxine free decreased 18.41 9.99 12 79426 831 64418463
Hepatopulmonary syndrome 18.40 9.99 5 79433 33 64419261
Hypothermia 18.31 9.99 60 79378 19796 64399498
Persecutory delusion 18.20 9.99 24 79414 4134 64415160
Heart rate decreased 18.06 9.99 123 79315 54944 64364350
Cardiac failure congestive 18.04 9.99 91 79347 130489 64288805
Unresponsive to stimuli 18.01 9.99 115 79323 50278 64369016
Acquired porphyria 17.91 9.99 5 79433 37 64419257
Wrong strength 17.86 9.99 7 79431 161 64419133
Urinary tract infection 17.69 9.99 191 79247 231405 64187889
Acute stress disorder 17.58 9.99 9 79429 394 64418900
Pituitary apoplexy 17.50 9.99 7 79431 170 64419124
Atrial fibrillation 17.49 9.99 131 79307 170958 64248336
Sleep paralysis 17.46 9.99 10 79428 548 64418746
Coma scale abnormal 17.41 9.99 33 79405 7741 64411553
Dystonia 17.39 9.99 57 79381 18808 64400486
Psychotic symptom 17.34 9.99 17 79421 2121 64417173
Porphyrins stool increased 17.15 9.99 5 79433 44 64419250
Hyperthermia 17.14 9.99 50 79388 15500 64403794
Thyrotoxic cardiomyopathy 17.10 9.99 3 79435 0 64419294
Somnambulism 17.06 9.99 26 79412 5115 64414179
Vasoplegia syndrome 17.06 9.99 19 79419 2748 64416546
Renal impairment 17.04 9.99 97 79341 134920 64284374
Portal hypertensive gastropathy 17.02 9.99 13 79425 1159 64418135
C-reactive protein increased 16.90 9.99 60 79378 94849 64324445
Apraxia 16.89 9.99 18 79420 2477 64416817
Lung neoplasm malignant 16.89 9.99 3 79435 21445 64397849
Cognitive disorder 16.87 9.99 121 79317 54966 64364328
Therapeutic product effective for unapproved indication 16.77 9.99 6 79432 106 64419188
Hyponatraemia 16.67 9.99 266 79172 148073 64271221
Haematemesis 16.64 9.99 107 79331 46892 64372402
Chemical burn 16.51 9.99 9 79429 448 64418846
Nodal rhythm 16.47 9.99 19 79419 2855 64416439
Paraganglion neoplasm 16.39 9.99 4 79434 16 64419278
Feeling guilty 16.24 9.99 11 79427 812 64418482
Mobility decreased 16.14 9.99 53 79385 85787 64333507
Memory impairment 16.14 9.99 169 79269 85513 64333781
Distractibility 16.11 9.99 10 79428 636 64418658
Oesophageal variceal ligation 16.04 9.99 6 79432 121 64419173
Myocardial infarction 16.00 9.99 129 79309 165692 64253602
Acute myeloid leukaemia 15.80 9.99 7 79431 27456 64391838
Hyponatraemic seizure 15.74 9.99 9 79429 492 64418802
Exposure via transplant 15.66 9.99 4 79434 20 64419274
Psychomotor retardation 15.66 9.99 25 79413 5118 64414176
Myelosuppression 15.50 9.99 5 79433 23825 64395469
Lip swelling 15.47 9.99 79 79359 31828 64387466
Bronchitis 15.47 9.99 75 79363 108668 64310626
Back pain 15.45 9.99 216 79222 249955 64169339
Perseveration 15.14 9.99 8 79430 374 64418920
White blood cell count decreased 15.13 9.99 123 79315 157714 64261580
Pseudoporphyria 15.08 9.99 9 79429 533 64418761
Basedow's disease 15.07 9.99 7 79431 247 64419047
Drooling 15.04 9.99 25 79413 5294 64414000
Hepatic failure 14.89 9.99 118 79320 55276 64364018
Laryngeal dyspnoea 14.84 9.99 7 79431 256 64419038
Food craving 14.80 9.99 13 79425 1411 64417883
Death 14.63 9.99 468 78970 482237 63937057
Palmar erythema 14.63 9.99 14 79424 1696 64417598
Intentional product use issue 14.61 9.99 64 79374 95300 64323994
Retroperitoneal fibrosis 14.59 9.99 9 79429 566 64418728
Psychomotor hyperactivity 14.54 9.99 45 79393 14406 64404888
Oedema 14.52 9.99 61 79377 91874 64327420
Mucosal inflammation 14.46 9.99 35 79403 62549 64356745
Vertigo 14.41 9.99 123 79315 58888 64360406
Rhinorrhoea 14.28 9.99 33 79405 59936 64359358
Narrow anterior chamber angle 14.27 9.99 6 79432 166 64419128
Dissociation 14.15 9.99 18 79420 2993 64416301
Drug level increased 14.10 9.99 81 79357 34115 64385179
Dizziness 14.06 9.99 656 78782 429507 63989787
Blood lactic acid increased 14.01 9.99 36 79402 10365 64408929
Ear discomfort 14.01 9.99 29 79409 7251 64412043
Cough 14.01 9.99 275 79163 301873 64117421
Genotype drug resistance test positive 13.90 9.99 11 79427 1033 64418261
Pleural effusion 13.86 9.99 95 79343 126464 64292830
Right aortic arch 13.81 9.99 3 79435 6 64419288
Peritoneal fibrosis 13.81 9.99 3 79435 6 64419288
Exposure via ingestion 13.80 9.99 23 79415 4879 64414415
Muscle rigidity 13.68 9.99 50 79388 17423 64401871
Neuroleptic malignant syndrome 13.63 9.99 64 79374 24932 64394362
Enuresis 13.62 9.99 17 79421 2773 64416521
Hyperbilirubinaemia 13.61 9.99 57 79381 21148 64398146
Adrenal suppression 13.56 9.99 12 79426 1315 64417979
Hypertrophic cardiomyopathy 13.47 9.99 14 79424 1872 64417422
International normalised ratio increased 13.47 9.99 51 79387 79116 64340178
Blood pressure systolic decreased 13.44 9.99 32 79406 8788 64410506
Musculoskeletal pain 13.42 9.99 53 79385 81241 64338053
Salivary hypersecretion 13.40 9.99 39 79399 12074 64407220
Withdrawal hypertension 13.39 9.99 7 79431 320 64418974
Blood creatinine increased 13.39 9.99 105 79333 135677 64283617
Abnormal faeces 13.28 9.99 25 79413 5834 64413460
Therapeutic product effect incomplete 13.24 9.99 74 79364 103408 64315886
Insomnia 13.20 9.99 328 79110 197508 64221786
Transfusion 13.17 9.99 3 79435 17991 64401303
Gastrointestinal motility disorder 12.88 9.99 23 79415 5156 64414138
Sinoatrial block 12.83 9.99 11 79427 1155 64418139
Gynaecomastia 12.81 9.99 25 79413 5991 64413303
Septic shock 12.63 9.99 77 79361 105360 64313934
Maternal exposure during pregnancy 12.58 9.99 68 79370 95816 64323478
Pulmonary mass 12.49 9.99 7 79431 24009 64395285
Agoraphobia 12.47 9.99 8 79430 539 64418755
Oxygen saturation decreased 12.46 9.99 79 79359 107097 64312197
Affective disorder 12.42 9.99 26 79412 6554 64412740
Chromaturia 12.41 9.99 58 79380 22553 64396741
Schizophrenia 12.40 9.99 36 79402 11132 64408162
Arthritis 12.39 9.99 57 79381 83757 64335537
Hypotonia 12.31 9.99 36 79402 11176 64408118
Aspiration of gastric residual 12.29 9.99 3 79435 12 64419282
Apathy 12.27 9.99 36 79402 11196 64408098
Alcohol use 12.17 9.99 21 79417 4581 64414713
Differential white blood cell count abnormal 12.15 9.99 13 79425 1797 64417497
Sedation 12.08 9.99 90 79348 41372 64377922
Fatigue 12.04 9.99 778 78660 747952 63671342
Thyroid cancer metastatic 12.01 9.99 5 79433 135 64419159
Breath holding 11.91 9.99 4 79434 58 64419236
Patient dissatisfaction with treatment 11.91 9.99 5 79433 138 64419156
Drug dependence 11.89 9.99 76 79362 33236 64386058
Mental disorder 11.81 9.99 64 79374 26381 64392913
Basilar migraine 11.79 9.99 4 79434 60 64419234
Bronchial hyperreactivity 11.77 9.99 15 79423 2497 64416797
Contraindicated product administered 11.77 9.99 81 79357 107748 64311546
Tonic convulsion 11.74 9.99 13 79425 1868 64417426
Bone marrow failure 11.73 9.99 26 79412 47926 64371368
Lymphadenopathy 11.68 9.99 25 79413 46661 64372633
Negative thoughts 11.67 9.99 11 79427 1307 64417987
Essential tremor 11.67 9.99 11 79427 1308 64417986
Blood pressure immeasurable 11.59 9.99 13 79425 1895 64417399
Abnormal behaviour 11.57 9.99 76 79362 33546 64385748
Ill-defined disorder 11.52 9.99 23 79415 44029 64375265
Hallucinations, mixed 11.52 9.99 24 79414 6028 64413266
Brugada syndrome 11.52 9.99 10 79428 1068 64418226
Ventricular tachycardia 11.51 9.99 77 79361 34188 64385106
Obsessive-compulsive disorder 11.48 9.99 21 79417 4797 64414497
Blood thyroid stimulating hormone decreased 11.47 9.99 22 79416 5208 64414086
Ear infection 11.38 9.99 58 79380 23346 64395948
Red blood cell sedimentation rate abnormal 11.38 9.99 3 79435 16303 64402991
Myoclonus 11.36 9.99 61 79377 25057 64394237
Hypovolaemic shock 11.31 9.99 33 79405 10233 64409061
Cardiotoxicity 11.29 9.99 33 79405 10241 64409053
Jaundice 11.26 9.99 100 79338 48412 64370882
Respiratory rate decreased 11.24 9.99 20 79418 4471 64414823
Hyperkalaemia 11.23 9.99 181 79257 100948 64318346
Wheezing 11.21 9.99 56 79382 80523 64338771
Blood calcium decreased 11.21 9.99 9 79429 25545 64393749
Subdural hygroma 11.19 9.99 7 79431 451 64418843
Monocyte count abnormal 11.19 9.99 5 79433 161 64419133
Sputum discoloured 11.18 9.99 4 79434 17852 64401442
Loss of bladder sensation 11.17 9.99 4 79434 71 64419223
Thrombosis 11.07 9.99 47 79391 70595 64348699
Alveolar bone resorption 11.06 9.99 4 79434 73 64419221
Sudden infant death syndrome 11.05 9.99 5 79433 166 64419128
Erythema 11.02 9.99 163 79275 186907 64232387
Joint range of motion decreased 11.02 9.99 5 79433 19338 64399956
Goitre 11.00 9.99 21 79417 4952 64414342
Change in seizure presentation 10.96 9.99 6 79432 301 64418993
Meningitis streptococcal 10.91 9.99 5 79433 171 64419123
Hypervolaemia 10.89 9.99 19 79419 38266 64381028
Altered state of consciousness 10.89 9.99 82 79356 37820 64381474
Sleep deficit 10.86 9.99 9 79429 902 64418392
Genital swelling 10.84 9.99 6 79432 308 64418986
Discomfort 10.80 9.99 57 79381 80821 64338473
Product communication issue 10.80 9.99 7 79431 480 64418814
Tongue pruritus 10.79 9.99 7 79431 481 64418813
Haemorrhagic tumour necrosis 10.77 9.99 3 79435 22 64419272
Bleeding varicose vein 10.75 9.99 7 79431 484 64418810
Violence-related symptom 10.74 9.99 8 79430 687 64418607
Thinking abnormal 10.73 9.99 35 79403 11521 64407773
Pharyngitis 10.72 9.99 5 79433 19034 64400260
Transplant rejection 10.72 9.99 4 79434 17397 64401897
Therapeutic response increased 10.68 9.99 7 79431 489 64418805
Pancytopenia 10.61 9.99 119 79319 143190 64276104
Tinea versicolour 10.56 9.99 6 79432 324 64418970
Injection site pruritus 10.55 9.99 19 79419 37807 64381487
Inflammation 10.51 9.99 43 79395 65257 64354037
Cerebral vasoconstriction 10.44 9.99 10 79428 1212 64418082
Tri-iodothyronine decreased 10.42 9.99 5 79433 190 64419104
Dyspnoea exertional 10.40 9.99 51 79387 73679 64345615
Abdominal cavity drainage 10.38 9.99 8 79430 723 64418571
Mixed anxiety and depressive disorder 10.32 9.99 5 79433 194 64419100
Blister 10.30 9.99 58 79380 80909 64338385
Multiple lentigines syndrome 10.30 9.99 5 79433 195 64419099
Alcoholic liver disease 10.28 9.99 7 79431 521 64418773
Pneumonitis 10.24 9.99 30 79408 50335 64368959
Bruxism 10.20 9.99 17 79421 3607 64415687
Full blood count abnormal 10.18 9.99 13 79425 29744 64389550
Right ventricular failure 10.14 9.99 7 79431 21464 64397830
Diplopia 10.14 9.99 62 79376 26703 64392591
Secondary hypogonadism 10.11 9.99 6 79432 352 64418942
Knee arthroplasty 10.09 9.99 11 79427 26988 64392306
Defect conduction intraventricular 10.07 9.99 6 79432 354 64418940
Tumour rupture 10.06 9.99 6 79432 355 64418939
Hip arthroplasty 10.03 9.99 7 79431 21344 64397950
Procedural hypotension 10.03 9.99 12 79426 1874 64417420
Electrocardiogram T wave inversion 10.02 9.99 20 79418 4874 64414420
Hepatic steatosis 10.01 9.99 69 79369 30938 64388356

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AA05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
ATC C07BA05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, non-selective, and thiazides
ATC C07FX01 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35530 beta-adrenergic blockers
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:85234 human blood serum metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Supraventricular tachycardia indication 6456007
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Angina pectoris indication 194828000
Hypertrophic cardiomyopathy indication 233873004 DOID:11984
Idiopathic hypertrophic subaortic stenosis indication 360465008
Hemangioma indication 400210000 DOID:255
Essential tremor indication 609558009 DOID:4990
Arrhythmias During Surgery indication
Migraine Prevention indication
Life-Threatening Ventricular Tachycardia indication
Myocardial Reinfarction Prevention indication
Pheochromocytoma Adjunct Therapy indication
Thyrotoxicosis off-label use 90739004 DOID:7997
Mitral valve prolapse off-label use 409712001
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Prevention of Bleeding Esophageal Varices off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Chronic bronchitis contraindication 63480004 DOID:6132
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of muscle contraindication 129565002 DOID:423
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
4.28MG/ML HEMANGEOL PIERRE FABRE DERMA N205410 March 14, 2014 RX SOLUTION ORAL 8338489 Oct. 16, 2028 METHOD TO TREAT HEMANGIOMA.
4.28MG/ML HEMANGEOL PIERRE FABRE DERMA N205410 March 14, 2014 RX SOLUTION ORAL 8987262 Oct. 16, 2028 METHOD TO TREAT INFANTILE HEMANGIOMA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 8.71 WOMBAT-PK DRUG LABEL
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 8.25 WOMBAT-PK DRUG LABEL
Sodium-dependent serotonin transporter Transporter Ki 6.70 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 6.91 PDSP
5-hydroxytryptamine receptor 2A GPCR Ki 5.38 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 6.66 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.92 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 DRUG MATRIX
Histamine H1 receptor GPCR Ki 4.70 WOMBAT-PK
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 6.22 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 6.20 PDSP
5-hydroxytryptamine receptor 1D GPCR Ki 5.35 PDSP
Cytochrome P450 2D6 Enzyme IC50 5.70 DRUG MATRIX
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 4.32 WOMBAT-PK
Cytochrome P450 1A2 Enzyme IC50 5.40 DRUG MATRIX
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.92 DRUG MATRIX
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 4.30 WOMBAT-PK
Solute carrier family 22 member 1 Transporter IC50 4.20 CHEMBL
Multidrug resistance protein 1 Transporter Ki 4.32 CHEMBL
5-hydroxytryptamine receptor 1B GPCR Ki 7.30 CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.67 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 4.89 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.05 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 9.01 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 9.05 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 8.52 CHEMBL
Beta-2 adrenergic receptor GPCR IC50 7.77 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 8.76 CHEMBL
Adrenergic receptor beta GPCR Ki 8.62 CHEMBL
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 6.60 IUPHAR
Beta-1 adrenergic receptor GPCR Ki 8.62 CHEMBL

External reference:

IDSource
4019916 VUID
N0000148001 NUI
D00483 KEGG_DRUG
318-98-9 SECONDARY_CAS_RN
4017831 VANDF
4019916 VANDF
C0033497 UMLSCUI
CHEBI:8499 CHEBI
CHEMBL27 ChEMBL_ID
DB00571 DRUGBANK_ID
CHEMBL1671 ChEMBL_ID
D011433 MESH_DESCRIPTOR_UI
4946 PUBCHEM_CID
564 IUPHAR_LIGAND_ID
1940 INN_ID
9Y8NXQ24VQ UNII
82084 RXNORM
2240 MMSL
5375 MMSL
d00032 MMSL
001850 NDDF
004740 NDDF
372772003 SNOMEDCT_US
55745002 SNOMEDCT_US
65088001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3727 SOLUTION 20 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3730 SOLUTION 40 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1659 TABLET 10 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1660 TABLET 20 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1661 TABLET 40 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1662 TABLET 80 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1693 TABLET 60 mg ORAL ANDA 19 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0908 SOLUTION 20 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9872 INJECTION 1 mg INTRAVENOUS ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2778 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2779 CAPSULE, EXTENDED RELEASE 80 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2780 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2781 CAPSULE, EXTENDED RELEASE 160 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0182 TABLET 10 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0182 TABLET 10 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0183 TABLET 20 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0183 TABLET 20 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0184 TABLET 40 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0184 TABLET 40 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0185 TABLET 80 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0185 TABLET 80 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0187 TABLET 60 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0187 TABLET 60 mg ORAL ANDA 23 sections
PROPRANOLOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9944 INJECTION 1 mg INTRAVENOUS ANDA 12 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4116 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4117 CAPSULE, EXTENDED RELEASE 80 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4118 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4119 CAPSULE, EXTENDED RELEASE 160 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5554 TABLET 10 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5555 TABLET 20 mg ORAL ANDA 21 sections