propranolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 2303 525-66-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propranolol
  • betalong
  • DL-Propranolol
  • racemic propranolol
  • beta-Propranolol
  • propranolol hydrochloride
  • hemangiol
  • propranolol HCl
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
  • Molecular weight: 259.35
  • Formula: C16H21NO2
  • CLOGP: 2.75
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.49
  • ALOGS: -3.51
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.16 g O
0.16 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 35.25 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 26 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 13, 1967 FDA BAXTER HLTHCARE CORP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 547.00 9.90 811 61173 145109 46478969
Product administered to patient of inappropriate age 429.07 9.90 154 61830 2542 46621536
Bradycardia 328.37 9.90 422 61562 65876 46558202
Toxicity to various agents 314.65 9.90 795 61189 210971 46413107
Cardiac arrest 231.89 9.90 424 61560 89975 46534103
Rheumatoid arthritis 182.53 9.90 47 61937 240168 46383910
Overdose 180.27 9.90 410 61574 101569 46522509
Migraine 148.30 9.90 303 61681 69723 46554355
Intentional overdose 138.69 9.90 282 61702 64662 46559416
Coma 133.76 9.90 261 61723 58088 46565990
Hypotension 118.25 9.90 615 61369 231974 46392104
Cardiogenic shock 108.48 9.90 121 61863 16263 46607815
Cardio-respiratory arrest 97.26 9.90 233 61751 59636 46564442
Electrocardiogram QRS complex prolonged 93.88 9.90 69 61915 5380 46618698
Respiratory arrest 93.47 9.90 164 61820 33652 46590426
Suicidal ideation 80.59 9.90 209 61775 56173 46567905
Circulatory collapse 77.56 9.90 118 61866 21506 46602572
Hypoglycaemia 77.21 9.90 201 61783 54148 46569930
Drug interaction 76.36 9.90 496 61488 202598 46421480
Electrocardiogram QT prolonged 76.20 9.90 193 61791 51132 46572946
Peripheral coldness 76.16 9.90 79 61905 9776 46614302
Seizure 75.03 9.90 343 61641 122711 46501367
Drug withdrawal syndrome 72.07 9.90 130 61854 27254 46596824
Infantile spitting up 71.51 9.90 16 61968 35 46624043
Thyrotoxic crisis 69.96 9.90 29 61955 716 46623362
Pulseless electrical activity 69.44 9.90 65 61919 7102 46616976
Sleep terror 68.54 9.90 29 61955 755 46623323
Joint swelling 66.97 9.90 73 61911 166000 46458078
Phaeochromocytoma 64.32 9.90 24 61960 444 46623634
Nightmare 62.99 9.90 93 61891 16505 46607573
Synovitis 62.20 9.90 5 61979 61070 46563008
Brain injury 61.95 9.90 57 61927 6093 46617985
Hyperthyroidism 60.17 9.90 76 61908 11635 46612443
Tremor 59.46 9.90 307 61677 115332 46508746
Hypoglycaemic seizure 58.42 9.90 23 61961 495 46623583
Sinus bradycardia 57.83 9.90 81 61903 13701 46610377
Suicide attempt 56.35 9.90 181 61803 54855 46569223
Hepatic encephalopathy 52.32 9.90 66 61918 10091 46613987
Pneumonia 52.23 9.90 290 61694 376030 46248048
Infusion related reaction 48.45 9.90 38 61946 101170 46522908
Retinal detachment 47.01 9.90 45 61939 5055 46619023
Poisoning deliberate 46.50 9.90 55 61929 7871 46616207
Shock 44.40 9.90 93 61891 21752 46602326
Insulin autoimmune syndrome 42.93 9.90 11 61973 51 46624027
Brain death 42.54 9.90 33 61951 2790 46621288
Drug ineffective for unapproved indication 42.01 9.90 77 61907 16336 46607742
Panic attack 40.94 9.90 86 61898 20156 46603922
Arthralgia 40.81 9.90 300 61684 364303 46259775
Eosinophilic myocarditis 40.10 9.90 16 61968 357 46623721
Contraindicated product administered 39.56 9.90 29 61955 79918 46544160
Ulcerated haemangioma 39.38 9.90 7 61977 0 46624078
Peripheral swelling 37.34 9.90 98 61886 157973 46466105
Respiratory depression 37.01 9.90 60 61924 11540 46612538
Oesophageal varices haemorrhage 36.97 9.90 22 61962 1201 46622877
Hyperreflexia 36.84 9.90 40 61944 5214 46618864
Electrocardiogram QRS complex shortened 36.31 9.90 15 61969 367 46623711
Infection 36.20 9.90 77 61907 133515 46490563
Disease progression 35.82 9.90 41 61943 91259 46532819
Somatic delusion 35.48 9.90 17 61967 596 46623482
Foetal alcohol syndrome 35.01 9.90 8 61976 20 46624058
Somnolence 34.85 9.90 339 61645 156182 46467896
Depressed level of consciousness 34.65 9.90 140 61844 47429 46576649
Galactorrhoea 34.05 9.90 33 61951 3764 46620314
Atrioventricular block 33.10 9.90 43 61941 6768 46617310
Hyperhidrosis 32.80 9.90 217 61767 89091 46534987
Wound 31.26 9.90 9 61975 42793 46581285
Disturbance in attention 30.68 9.90 102 61882 31458 46592620
Infusion site streaking 30.67 9.90 13 61971 340 46623738
Ear infection 30.52 9.90 83 61901 22930 46601148
Varices oesophageal 30.10 9.90 27 61957 2792 46621286
Hypothermia 29.73 9.90 56 61928 12127 46611951
Palpitations 29.46 9.90 222 61762 95037 46529041
Neuropathy peripheral 29.40 9.90 47 61937 90846 46533232
Systemic lupus erythematosus 29.30 9.90 26 61958 65154 46558924
Pain 29.11 9.90 452 61532 476496 46147582
Rash 29.05 9.90 318 61666 356194 46267884
Akathisia 28.94 9.90 43 61941 7671 46616407
Death 28.67 9.90 296 61688 335252 46288826
Confusional state 28.43 9.90 331 61653 159561 46464517
Vision blurred 28.26 9.90 192 61792 79516 46544562
Hallucination, auditory 28.21 9.90 51 61933 10705 46613373
Hepatocellular carcinoma 27.99 9.90 26 61958 2813 46621265
Glossodynia 27.84 9.90 12 61972 44361 46579717
Hand deformity 27.71 9.90 6 61978 34568 46589510
Cough 27.40 9.90 186 61798 230063 46394015
Drug ineffective 27.28 9.90 689 61295 677149 45946929
Arthropathy 27.20 9.90 44 61940 84656 46539422
Exposure via ingestion 27.16 9.90 28 61956 3439 46620639
Depression 27.14 9.90 345 61639 169759 46454319
Lethargy 27.07 9.90 137 61847 51034 46573044
Agoraphobia 27.03 9.90 12 61972 352 46623726
Haemoglobin decreased 26.75 9.90 85 61899 128864 46495214
Hepatic enzyme increased 26.73 9.90 42 61942 81745 46542333
Dystonia 26.55 9.90 51 61933 11206 46612872
Anxiety 26.11 9.90 362 61622 181595 46442483
Pain in extremity 26.03 9.90 219 61765 258461 46365617
Hallucination 25.91 9.90 133 61851 49818 46574260
Panic reaction 25.72 9.90 28 61956 3661 46620417
Hyperammonaemic encephalopathy 25.25 9.90 21 61963 1961 46622117
Pyrexia 24.99 9.90 320 61664 348482 46275596
Hyperthermia 24.95 9.90 41 61943 7973 46616105
Poisoning 24.38 9.90 56 61928 13938 46610140
Neutropenia 24.05 9.90 103 61881 143101 46480977
Apraxia 23.99 9.90 19 61965 1656 46622422
Interstitial lung disease 23.68 9.90 22 61962 53927 46570151
Derailment 23.25 9.90 7 61977 64 46624014
Loss of consciousness 22.89 9.90 232 61752 108006 46516072
Accelerated idioventricular rhythm 22.72 9.90 6 61978 32 46624046
Atrioventricular block first degree 22.52 9.90 34 61950 6152 46617926
C-reactive protein increased 22.24 9.90 27 61957 58563 46565515
Nasopharyngitis 22.21 9.90 117 61867 153881 46470197
Febrile neutropenia 22.08 9.90 59 61925 94568 46529510
Sleep disorder 21.81 9.90 121 61863 46674 46577404
Withdrawal syndrome 21.69 9.90 63 61921 18071 46606007
Serotonin syndrome 21.54 9.90 76 61908 24144 46599934
Inappropriate schedule of product administration 21.51 9.90 154 61830 64859 46559219
Pleural effusion 21.48 9.90 49 61935 82903 46541175
Retroperitoneal fibrosis 21.35 9.90 10 61974 333 46623745
Cholestasis of pregnancy 21.11 9.90 15 61969 1109 46622969
Herpes zoster 21.10 9.90 36 61948 67836 46556242
Essential tremor 21.10 9.90 13 61971 756 46623322
Narrow anterior chamber angle 20.86 9.90 6 61978 46 46624032
Dizziness 20.73 9.90 595 61389 339819 46284259
Heart rate decreased 20.48 9.90 90 61894 31633 46592445
Therapeutic product effect decreased 20.43 9.90 50 61934 82551 46541527
Metabolic acidosis 19.93 9.90 103 61881 38677 46585401
Infantile haemangioma 19.82 9.90 6 61978 56 46624022
Pituitary apoplexy 19.70 9.90 7 61977 112 46623966
Cyanosis 19.60 9.90 56 61928 15915 46608163
Porphyrins urine increased 19.55 9.90 5 61979 23 46624055
Acquired porphyria 19.55 9.90 5 61979 23 46624055
Extrapyramidal disorder 19.52 9.90 45 61939 11223 46612855
Wrong patient received product 19.27 9.90 17 61967 1720 46622358
Accessory cardiac pathway 19.27 9.90 4 61980 5 46624073
Lower respiratory tract infection 19.25 9.90 27 61957 55062 46569016
Mydriasis 19.24 9.90 43 61941 10510 46613568
Therapeutic product ineffective for unapproved indication 19.21 9.90 8 61976 200 46623878
Coma scale abnormal 18.92 9.90 28 61956 4978 46619100
Urinary tract infection 18.90 9.90 194 61790 220072 46404006
Ventricular arrhythmia 18.85 9.90 23 61961 3398 46620680
Agitation 18.76 9.90 132 61852 55283 46568795
Laryngeal dyspnoea 18.73 9.90 7 61977 130 46623948
Lip swelling 18.69 9.90 75 61909 25320 46598758
Irritability 18.59 9.90 82 61902 28864 46595214
Oedema peripheral 18.49 9.90 130 61854 159576 46464502
Therapeutic product effective for unapproved indication 18.46 9.90 6 61978 72 46624006
Gynaecomastia 18.44 9.90 7 61977 136 46623942
Porphyrins stool increased 18.44 9.90 5 61979 30 46624048
Alopecia 18.42 9.90 133 61851 162281 46461797
Unresponsive to stimuli 18.34 9.90 88 61896 32086 46591992
Poor quality sleep 18.25 9.90 53 61931 15200 46608878
Fatigue 18.15 9.90 644 61340 608053 46016025
Stomatitis 17.96 9.90 40 61944 68257 46555821
Abdominal discomfort 17.52 9.90 123 61861 151042 46473036
Muscle rigidity 17.50 9.90 40 61944 9921 46614157
Perseveration 17.40 9.90 8 61976 255 46623823
Sinusitis 17.39 9.90 101 61883 129667 46494411
Swelling 17.18 9.90 96 61888 124415 46499663
Tearfulness 16.90 9.90 24 61960 4111 46619967
Thyrotoxic cardiomyopathy 16.88 9.90 3 61981 0 46624078
Depressed mood 16.78 9.90 88 61896 33231 46590847
Hallucination, visual 16.69 9.90 57 61927 17816 46606262
Torsade de pointes 16.28 9.90 44 61940 12110 46611968
Off label use 16.24 9.90 637 61347 379204 46244874
Tumour rupture 16.23 9.90 6 61978 108 46623970
Musculoskeletal stiffness 16.13 9.90 71 61913 97922 46526156
Suspected suicide 16.10 9.90 25 61959 4636 46619442
Food craving 16.01 9.90 13 61971 1174 46622904
Defect conduction intraventricular 15.98 9.90 6 61978 113 46623965
Haematemesis 15.85 9.90 78 61906 28728 46595350
Pericarditis 15.77 9.90 6 61978 23921 46600157
Teething 15.71 9.90 4 61980 18 46624060
Depersonalisation/derealisation disorder 15.64 9.90 12 61972 998 46623080
Oculogyric crisis 15.58 9.90 13 61971 1220 46622858
Mental disorder 15.53 9.90 65 61919 22360 46601718
Malignant neoplasm progression 15.51 9.90 40 61944 64886 46559192
Abnormal weight gain 15.47 9.90 14 61970 1464 46622614
Cerebral vasoconstriction 15.40 9.90 12 61972 1021 46623057
Exposure via transplant 15.36 9.90 4 61980 20 46624058
Thyroxine free decreased 15.28 9.90 9 61975 482 46623596
Muscle contractions involuntary 15.27 9.90 16 61968 2002 46622076
Self-injurious ideation 15.24 9.90 17 61967 2283 46621795
Stress ulcer 15.23 9.90 5 61979 62 46624016
Tardive dyskinesia 15.19 9.90 32 61952 7511 46616567
Inappropriate affect 15.18 9.90 11 61973 839 46623239
Jaundice 15.09 9.90 77 61907 28768 46595310
Salivary hypersecretion 14.96 9.90 29 61955 6416 46617662
Anuria 14.93 9.90 41 61943 11390 46612688
Progressive supranuclear palsy 14.81 9.90 5 61979 68 46624010
Migraine with aura 14.75 9.90 16 61968 2083 46621995
Bradycardia foetal 14.69 9.90 8 61976 368 46623710
Hepatic steatosis 14.61 9.90 67 61917 23975 46600103
International normalised ratio increased 14.45 9.90 25 61959 46858 46577220
Treatment failure 14.40 9.90 69 61915 93018 46531060
Macroglossia 14.34 9.90 9 61975 541 46623537
Hypoperfusion 14.17 9.90 13 61971 1384 46622694
Inflammation 14.15 9.90 27 61957 48754 46575324
Adrenal suppression 14.08 9.90 11 61973 940 46623138
Gastrointestinal motility disorder 14.06 9.90 23 61961 4455 46619623
Bezoar 14.00 9.90 13 61971 1406 46622672
Capillary nail refill test abnormal 13.94 9.90 3 61981 5 46624073
Vertigo 13.73 9.90 117 61867 51931 46572147
Disorientation 13.72 9.90 90 61894 36828 46587250
Pulse absent 13.64 9.90 24 61960 4932 46619146
Congenital pharyngeal anomaly 13.59 9.90 3 61981 6 46624072
Sinus rhythm 13.55 9.90 9 61975 596 46623482
Haemodynamic instability 13.55 9.90 31 61953 7694 46616384
Asthma 13.50 9.90 69 61915 91473 46532605
Breast cancer 13.38 9.90 25 61959 45493 46578585
Somnambulism 13.36 9.90 24 61960 5013 46619065
Arthritis 13.35 9.90 55 61929 77261 46546817
Monoclonal gammopathy 13.26 9.90 9 61975 618 46623460
Chromaturia 13.24 9.90 47 61937 14972 46609106
Breath holding 13.21 9.90 6 61978 186 46623892
Hyperbilirubinaemia 13.20 9.90 37 61947 10401 46613677
Productive cough 13.09 9.90 30 61954 50685 46573393
Dermatitis diaper 13.00 9.90 6 61978 193 46623885
Abnormal faeces 12.99 9.90 21 61963 4028 46620050
Cytomegalovirus infection 12.91 9.90 4 61980 18140 46605938
Basilar migraine 12.88 9.90 4 61980 41 46624037
Ventricular fibrillation 12.86 9.90 39 61945 11457 46612621
Nervousness 12.85 9.90 73 61911 28402 46595676
Hepatic cirrhosis 12.83 9.90 48 61936 15684 46608394
Memory impairment 12.80 9.90 158 61826 77179 46546899
Suicidal behaviour 12.75 9.90 16 61968 2432 46621646
Product use in unapproved indication 12.68 9.90 179 61805 90094 46533984
Feeling guilty 12.68 9.90 8 61976 485 46623593
Hypersensitivity 12.64 9.90 133 61851 150188 46473890
Hypermobility syndrome 12.61 9.90 9 61975 670 46623408
Cerebellar syndrome 12.55 9.90 19 61965 3446 46620632
Generalised tonic-clonic seizure 12.55 9.90 70 61914 27052 46597026
Bundle branch block 12.54 9.90 10 61974 880 46623198
Intentional self-injury 12.29 9.90 64 61920 24102 46599976
Paraganglion neoplasm 12.27 9.90 3 61981 11 46624067
Diarrhoea 12.23 9.90 613 61371 558989 46065089
Ventricular failure 12.23 9.90 7 61977 355 46623723
Dyspnoea 12.20 9.90 560 61424 514988 46109090
Palmar erythema 12.10 9.90 12 61972 1408 46622670
Aphasia 12.09 9.90 72 61912 28495 46595583
Alveolar bone resorption 12.09 9.90 4 61980 51 46624027
Aspiration of gastric residual 12.07 9.90 3 61981 12 46624066
Sepsis 11.98 9.90 119 61865 135895 46488183
Multiple lentigines syndrome 11.96 9.90 6 61978 233 46623845
Swollen tongue 11.94 9.90 73 61911 29159 46594919
Brugada syndrome 11.93 9.90 6 61978 234 46623844
Pupil fixed 11.89 9.90 13 61971 1707 46622371
Abnormal dreams 11.61 9.90 35 61949 10244 46613834
Renal disorder 11.57 9.90 11 61973 26675 46597403
Wound infection bacterial 11.57 9.90 7 61977 394 46623684
Thyroid cancer metastatic 11.38 9.90 5 61979 143 46623935
Septic arthritis staphylococcal 11.31 9.90 7 61977 410 46623668
Dyspnoea exertional 11.24 9.90 32 61952 50257 46573821
Change in seizure presentation 11.22 9.90 6 61978 266 46623812
Metastases to liver 11.21 9.90 6 61978 19579 46604499
Atrophy 11.20 9.90 12 61972 1541 46622537
Sinoatrial block 11.12 9.90 9 61975 809 46623269
Portal vein thrombosis 11.10 9.90 15 61969 2452 46621626
Dissociation 10.97 9.90 13 61971 1864 46622214
Oromandibular dystonia 10.88 9.90 7 61977 439 46623639
Cutaneous lupus erythematosus 10.81 9.90 15 61969 2514 46621564
Rhythm idioventricular 10.80 9.90 5 61979 162 46623916
Postresuscitation encephalopathy 10.79 9.90 3 61981 20 46624058
Tongue pruritus 10.73 9.90 7 61977 450 46623628
Formication 10.68 9.90 19 61965 3937 46620141
Actinic keratosis 10.67 9.90 14 61970 2225 46621853
Haemorrhagic tumour necrosis 10.67 9.90 3 61981 21 46624057
Broad ligament tear 10.67 9.90 3 61981 21 46624057
Tonic convulsion 10.65 9.90 10 61974 1096 46622982
Ear discomfort 10.63 9.90 26 61958 6735 46617343
Respiratory failure 10.57 9.90 78 61906 94738 46529340
Sleep paralysis 10.53 9.90 7 61977 464 46623614
Acne pustular 10.48 9.90 4 61980 79 46623999
Cardiac failure congestive 10.46 9.90 75 61909 91675 46532403
Apathy 10.43 9.90 27 61957 7241 46616837
Mood swings 10.40 9.90 46 61938 16206 46607872
Transposition of the great vessels 10.39 9.90 5 61979 177 46623901
Therapeutic product effect incomplete 10.37 9.90 61 61923 78092 46545986
Cognitive disorder 10.31 9.90 84 61900 36799 46587279
Electrocardiogram QT interval 10.21 9.90 4 61980 85 46623993
Nodal rhythm 10.17 9.90 12 61972 1713 46622365
Blood prolactin increased 10.13 9.90 16 61968 3011 46621067
Lung disorder 10.09 9.90 27 61957 43277 46580801
Impaired healing 10.09 9.90 21 61963 36722 46587356
Porphyria non-acute 10.02 9.90 6 61978 331 46623747
Basedow's disease 9.99 9.90 6 61978 333 46623745
Strabismus 9.96 9.90 12 61972 1750 46622328
Product complaint 9.94 9.90 37 61947 12064 46612014
Back pain 9.92 9.90 208 61776 209831 46414247
Mobility decreased 9.91 9.90 44 61940 60550 46563528

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 264.28 11.02 440 34465 99052 29818521
Hepatic encephalopathy 217.68 11.02 159 34746 14033 29903540
Product administered to patient of inappropriate age 190.01 11.02 81 34824 2462 29915111
Bradycardia 186.20 11.02 299 34606 65227 29852346
Toxicity to various agents 126.57 11.02 473 34432 176710 29740863
Ascites 110.34 11.02 170 34735 35751 29881822
Hyperthyroidism 92.04 11.02 76 34829 8022 29909551
Oesophageal varices haemorrhage 85.76 11.02 50 34855 3001 29914572
Cardiac arrest 80.03 11.02 264 34641 92586 29824987
Varices oesophageal 76.81 11.02 49 34856 3460 29914113
Hepatic cirrhosis 73.58 11.02 92 34813 15907 29901666
Akathisia 66.24 11.02 55 34850 5849 29911724
Hepatocellular carcinoma 65.90 11.02 68 34837 9542 29908031
Hepatorenal syndrome 62.37 11.02 38 34867 2473 29915100
Encapsulating peritoneal sclerosis 59.74 11.02 24 34881 625 29916948
Febrile neutropenia 56.24 11.02 27 34878 106666 29810907
Pneumonia 54.10 11.02 204 34701 334102 29583471
Parasomnia 53.66 11.02 18 34887 276 29917297
Myokymia 51.29 11.02 13 34892 67 29917506
Intentional overdose 50.05 11.02 133 34772 41348 29876225
Drug interaction 47.72 11.02 396 34509 199172 29718401
Tremor 41.54 11.02 186 34719 75177 29842396
Cardio-respiratory arrest 39.90 11.02 152 34753 57154 29860419
Cerebral artery thrombosis 36.96 11.02 16 34889 505 29917068
Suicidal ideation 36.88 11.02 109 34796 36005 29881568
Granulomatous rosacea 36.58 11.02 12 34893 171 29917402
Overdose 36.34 11.02 194 34711 84143 29833430
Respiratory arrest 35.48 11.02 94 34811 29164 29888409
Thyrotoxic crisis 35.23 11.02 14 34891 354 29917219
Photophobia 34.20 11.02 38 34867 5798 29911775
Thyrotoxic periodic paralysis 34.08 11.02 9 34896 56 29917517
Aggression 33.59 11.02 107 34798 36800 29880773
Suicidal behaviour 32.27 11.02 20 34885 1342 29916231
Infantile spitting up 31.93 11.02 8 34897 39 29917534
Abnormal sleep-related event 30.72 11.02 14 34891 500 29917073
Premature baby 29.35 11.02 62 34843 16629 29900944
Granulocytopenia 28.93 11.02 36 34869 6190 29911383
Irritability 28.91 11.02 75 34830 22975 29894598
Peripheral coldness 28.90 11.02 37 34868 6546 29911027
Anxiety 28.61 11.02 191 34714 89680 29827893
Myocardial infarction 27.91 11.02 66 34839 125559 29792014
Migraine 27.66 11.02 52 34853 12822 29904751
Brain scan abnormal 27.54 11.02 14 34891 639 29916934
Foetal disorder 27.43 11.02 14 34891 644 29916929
Portal hypertensive gastropathy 26.70 11.02 13 34892 540 29917033
Portal vein thrombosis 26.47 11.02 26 34879 3438 29914135
Heat stroke 26.43 11.02 15 34890 855 29916718
Psychotic disorder 25.95 11.02 69 34836 21446 29896127
Cardiogenic shock 25.54 11.02 59 34846 16802 29900771
Hallucination, auditory 25.48 11.02 43 34862 9746 29907827
Sinus bradycardia 24.83 11.02 47 34858 11648 29905925
Disturbance in attention 24.72 11.02 69 34836 22060 29895513
Product use issue 24.16 11.02 112 34793 45904 29871669
Neutropenia neonatal 23.99 11.02 12 34893 529 29917044
Gastroenteritis eosinophilic 23.82 11.02 9 34896 198 29917375
Areflexia 23.80 11.02 22 34883 2697 29914876
Infantile haemangioma 23.02 11.02 4 34901 0 29917573
Acute stress disorder 22.46 11.02 8 34897 148 29917425
Portal hypertension 22.32 11.02 25 34880 3848 29913725
Dyspnoea 22.31 11.02 265 34640 333030 29584543
Torsade de pointes 22.01 11.02 34 34871 7156 29910417
Myocardial depression 21.87 11.02 6 34899 44 29917529
Platelet count decreased 21.82 11.02 58 34847 106071 29811502
Anhidrosis 21.52 11.02 7 34898 97 29917476
Sleep disorder 21.39 11.02 70 34835 24409 29893164
Poisoning deliberate 21.06 11.02 30 34875 5874 29911699
Agitation 21.01 11.02 121 34784 53952 29863621
Restlessness 20.99 11.02 66 34839 22533 29895040
Antipsychotic drug level increased 20.98 11.02 22 34883 3144 29914429
Hepatitis C 20.88 11.02 47 34858 13158 29904415
Differential white blood cell count abnormal 20.87 11.02 15 34890 1289 29916284
Peritoneal fibrosis 20.79 11.02 4 34901 3 29917570
Phaeochromocytoma malignant 20.78 11.02 6 34899 54 29917519
Cardiac failure congestive 20.67 11.02 42 34863 84365 29833208
Neutrophil count decreased 20.50 11.02 12 34893 42442 29875131
Neutropenia 20.32 11.02 79 34826 128461 29789112
Ventricular arrhythmia 20.25 11.02 25 34880 4263 29913310
Sepsis 20.07 11.02 95 34810 146300 29771273
Withdrawal syndrome 20.02 11.02 42 34863 11208 29906365
Hepatopulmonary syndrome 20.02 11.02 5 34900 24 29917549
Lethargy 19.88 11.02 95 34810 39424 29878149
White blood cell count decreased 19.52 11.02 43 34862 83904 29833669
Sexually inappropriate behaviour 19.50 11.02 9 34896 331 29917242
Hepatic failure 19.47 11.02 85 34820 33958 29883615
Drug withdrawal syndrome 19.47 11.02 59 34846 19750 29897823
Hepatitis C RNULL positive 19.37 11.02 8 34897 224 29917349
Disorientation 19.17 11.02 80 34825 31338 29886235
Poor quality sleep 19.10 11.02 32 34873 7209 29910364
Joint swelling 19.06 11.02 16 34889 46930 29870643
Alcoholic liver disease 19.05 11.02 11 34894 648 29916925
Dysmorphism 18.99 11.02 17 34888 2000 29915573
Hepatic cancer 18.71 11.02 30 34875 6518 29911055
Electrocardiogram QRS complex shortened 18.69 11.02 7 34898 150 29917423
Hypoaesthesia eye 18.68 11.02 5 34900 33 29917540
Psychomotor hyperactivity 18.65 11.02 34 34871 8190 29909383
Malignant neoplasm progression 18.53 11.02 35 34870 72252 29845321
Disease progression 18.50 11.02 41 34864 79833 29837740
Respiratory rate decreased 18.49 11.02 16 34889 1799 29915774
Interstitial lung disease 18.37 11.02 26 34879 60171 29857402
Heart rate decreased 18.31 11.02 60 34845 20934 29896639
Pseudoporphyria 18.26 11.02 8 34897 260 29917313
Persecutory delusion 18.13 11.02 17 34888 2123 29915450
Nightmare 18.01 11.02 42 34863 12034 29905539
Meningitis streptococcal 17.84 11.02 5 34900 40 29917533
Low birth weight baby 17.58 11.02 28 34877 6048 29911525
Social avoidant behaviour 17.39 11.02 19 34886 2844 29914729
Ammonia increased 17.31 11.02 23 34882 4218 29913355
Renal impairment 17.30 11.02 46 34859 84138 29833435
Endotoxaemia 17.27 11.02 3 34902 0 29917573
Sedation 17.26 11.02 50 34855 16323 29901250
Hyperhidrosis 16.97 11.02 135 34770 66955 29850618
Product communication issue 16.85 11.02 5 34900 50 29917523
Rash 16.78 11.02 143 34762 191746 29725827
Insomnia 16.58 11.02 174 34731 93162 29824411
Blood creatinine increased 16.55 11.02 53 34852 91322 29826251
Pyrexia 16.44 11.02 243 34662 294246 29623327
Plasma cell myeloma 16.41 11.02 23 34882 53439 29864134
Depression 16.26 11.02 169 34736 90268 29827305
Genotype drug resistance test positive 16.18 11.02 14 34891 1575 29915998
Oesophageal variceal ligation 16.03 11.02 5 34900 60 29917513
Agoraphobia 15.82 11.02 7 34898 233 29917340
Rheumatoid arthritis 15.57 11.02 15 34890 41182 29876391
Hypertrophic cardiomyopathy 15.55 11.02 11 34894 922 29916651
Coma 15.37 11.02 90 34815 40359 29877214
Gastric varices 15.32 11.02 8 34897 386 29917187
Poisoning 15.27 11.02 38 34867 11344 29906229
Patient dissatisfaction with treatment 15.26 11.02 5 34900 71 29917502
Strangulated umbilical hernia 15.19 11.02 3 34902 3 29917570
Renal hamartoma 15.19 11.02 3 34902 3 29917570
Encephalopathy 15.18 11.02 76 34829 32129 29885444
Somnolence 15.18 11.02 176 34729 96587 29820986
Depressed level of consciousness 15.15 11.02 86 34819 38136 29879437
Drooling 14.97 11.02 18 34887 2987 29914586
Sleep deficit 14.72 11.02 8 34897 419 29917154
Essential tremor 14.58 11.02 10 34895 797 29916776
Hypotonia neonatal 14.58 11.02 11 34894 1018 29916555
Unresponsive to stimuli 14.38 11.02 65 34840 26354 29891219
Phaeochromocytoma 14.30 11.02 6 34899 175 29917398
Defect conduction intraventricular 14.20 11.02 6 34899 178 29917395
Biliary anastomosis 14.16 11.02 4 34901 33 29917540
Spindle cell sarcoma 14.11 11.02 5 34900 91 29917482
Tinnitus 14.05 11.02 46 34859 16042 29901531
Delusion 14.00 11.02 38 34867 11951 29905622
Laryngeal erythema 13.98 11.02 3 34902 6 29917567
Micrographia 13.98 11.02 3 34902 6 29917567
Cryoglobulinaemia 13.84 11.02 7 34898 316 29917257
Hyperkalaemia 13.63 11.02 127 34778 65883 29851690
Pain 13.63 11.02 132 34773 172509 29745064
Stomatitis 13.60 11.02 14 34891 37265 29880308
Wrong strength 13.54 11.02 5 34900 103 29917470
Negative thoughts 13.53 11.02 9 34896 682 29916891
Atrioventricular block first degree 13.51 11.02 24 34881 5664 29911909
Phonophobia 13.40 11.02 5 34900 106 29917467
Muscle disorder 13.24 11.02 15 34890 2337 29915236
Salivary hypersecretion 13.18 11.02 28 34877 7538 29910035
Alcoholism 13.15 11.02 18 34887 3396 29914177
Thyroxine free increased 13.15 11.02 6 34899 215 29917358
Hypoglycaemia 13.11 11.02 103 34802 50878 29866695
Binocular eye movement disorder 13.05 11.02 4 34901 45 29917528
Tardive dyskinesia 12.88 11.02 22 34883 5035 29912538
Hypotension 12.82 11.02 315 34590 200250 29717323
Death 12.80 11.02 318 34587 356965 29560608
Coronary artery disease 12.80 11.02 24 34881 49688 29867885
Ventricular septal defect 12.69 11.02 18 34887 3511 29914062
Mood altered 12.64 11.02 29 34876 8221 29909352
Goitre 12.62 11.02 12 34893 1524 29916049
Foetal growth restriction 12.47 11.02 18 34887 3567 29914006
Foetal death 12.40 11.02 6 34899 246 29917327
Suicide attempt 12.27 11.02 79 34826 36618 29880955
Hallucination, visual 12.25 11.02 44 34861 16069 29901504
Acute myeloid leukaemia 12.15 11.02 3 34902 18003 29899570
Pulseless electrical activity 12.08 11.02 24 34881 6163 29911410
Tachycardia 11.95 11.02 135 34770 73604 29843969
Cognitive disorder 11.94 11.02 57 34848 23633 29893940
Action tremor 11.94 11.02 4 34901 61 29917512
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.92 11.02 8 34897 615 29916958
Gastric hypomotility 11.82 11.02 4 34901 63 29917510
Panic attack 11.66 11.02 29 34876 8652 29908921
Mucosal inflammation 11.65 11.02 11 34894 30483 29887090
Congenital hypothyroidism 11.60 11.02 3 34902 17 29917556
Loss of bladder sensation 11.43 11.02 4 34901 70 29917503
Maternal drugs affecting foetus 11.43 11.02 19 34886 4254 29913319
Blood pressure immeasurable 11.30 11.02 9 34896 902 29916671
Panic disorder 11.25 11.02 10 34895 1165 29916408
Chronic obstructive pulmonary disease 11.24 11.02 23 34882 46103 29871470
Stoma site haemorrhage 11.19 11.02 9 34896 915 29916658
Contraindication to medical treatment 11.18 11.02 7 34898 478 29917095
Bronchial hyperreactivity 11.09 11.02 10 34895 1188 29916385
Pain in extremity 11.08 11.02 79 34826 110142 29807431
Intrusive thoughts 11.08 11.02 4 34901 77 29917496
Brachiocephalic vein thrombosis 11.05 11.02 3 34902 21 29917552
Feeling of despair 11.05 11.02 9 34896 931 29916642

Pharmacologic Action:

SourceCodeDescription
ATC C07AA05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
ATC C07BA05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, non-selective, and thiazides
ATC C07FX01 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35474 minor tranquilisers
CHEBI has role CHEBI:35530 beta-adrenoceptor antagonists
CHEBI has role CHEBI:35620 vasodilator
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:85234 human blood serum metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Supraventricular tachycardia indication 6456007
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Angina pectoris indication 194828000
Hypertrophic cardiomyopathy indication 233873004 DOID:11984
Idiopathic hypertrophic subaortic stenosis indication 360465008
Hemangioma indication 400210000 DOID:255
Essential tremor indication 609558009 DOID:4990
Arrhythmias During Surgery indication
Migraine Prevention indication
Life-Threatening Ventricular Tachycardia indication
Myocardial Reinfarction Prevention indication
Pheochromocytoma Adjunct Therapy indication
Thyrotoxicosis off-label use 90739004 DOID:7997
Mitral valve prolapse off-label use 409712001
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Prevention of Bleeding Esophageal Varices off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Chronic bronchitis contraindication 63480004 DOID:6132
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of muscle contraindication 129565002 DOID:423
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
4.28MG/ML HEMANGEOL PIERRE FABRE DERMA N205410 March 14, 2014 RX SOLUTION ORAL March 14, 2021 TREATMENT OF PROLIFERATING INFANTILE HEMANGIOMA REQUIRING SYSTEMIC THERAPY.

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 8.25 WOMBAT-PK DRUG LABEL
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 8.71 WOMBAT-PK DRUG LABEL
5-hydroxytryptamine receptor 1B GPCR Ki 6.20 PDSP
5-hydroxytryptamine receptor 1D GPCR Ki 5.35 PDSP
5-hydroxytryptamine receptor 1A GPCR Ki 6.91 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.92 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 6.69 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 6.66 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.92 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 5.70 DRUG MATRIX
Cytochrome P450 1A2 Enzyme IC50 5.40 DRUG MATRIX
Multidrug resistance protein 1 Transporter Ki 4.32 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.20 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 4.30 WOMBAT-PK
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 4.32 WOMBAT-PK
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 6.22 WOMBAT-PK
Histamine H1 receptor GPCR Ki 4.70 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 5.38 PDSP
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.67 DRUG MATRIX
Beta-2 adrenergic receptor GPCR Kd 9.05 CHEMBL
5-hydroxytryptamine receptor 1B GPCR Ki 7.30 CHEMBL
Beta-2 adrenergic receptor GPCR IC50 7.77 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.05 CHEMBL
D(2) dopamine receptor GPCR Ki 4.89 CHEMBL
Adrenergic receptor beta GPCR Ki 8.62 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 8.52 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 9.01 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 8.76 CHEMBL
Beta-3 adrenergic receptor Unclassified ANTAGONIST Ki 6.60 IUPHAR

External reference:

IDSource
4019916 VUID
N0000148001 NUI
D00483 KEGG_DRUG
318-98-9 SECONDARY_CAS_RN
4017831 VANDF
4019916 VANDF
C0033497 UMLSCUI
CHEBI:8499 CHEBI
DB00571 DRUGBANK_ID
CHEMBL27 ChEMBL_ID
CHEMBL1671 ChEMBL_ID
D011433 MESH_DESCRIPTOR_UI
4946 PUBCHEM_CID
564 IUPHAR_LIGAND_ID
1940 INN_ID
9Y8NXQ24VQ UNII
82084 RXNORM
2240 MMSL
5375 MMSL
d00032 MMSL
001850 NDDF
004740 NDDF
372772003 SNOMEDCT_US
55745002 SNOMEDCT_US
65088001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3727 SOLUTION 20 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3730 SOLUTION 40 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1659 TABLET 10 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1660 TABLET 20 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1661 TABLET 40 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1662 TABLET 80 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1693 TABLET 60 mg ORAL ANDA 19 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9872 INJECTION 1 mg INTRAVENOUS ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2778 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2779 CAPSULE, EXTENDED RELEASE 80 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2780 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2781 CAPSULE, EXTENDED RELEASE 160 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0182 TABLET 10 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0183 TABLET 20 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0184 TABLET 40 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0185 TABLET 80 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0187 TABLET 60 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4116 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4117 CAPSULE, EXTENDED RELEASE 80 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4118 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4119 CAPSULE, EXTENDED RELEASE 160 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5554 TABLET 10 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5555 TABLET 20 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5556 TABLET 40 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5557 TABLET 80 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-5482 TABLET 10 mg ORAL ANDA 26 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-5483 TABLET 20 mg ORAL ANDA 26 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-5484 TABLET 40 mg ORAL ANDA 26 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-5485 TABLET 60 mg ORAL ANDA 26 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-5486 TABLET 80 mg ORAL ANDA 26 sections