All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

epoprostenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prostaglandins	1034	35121-78-9

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: epoprostenol epoprostenol sodium prostacyclin vasocyclin Prostaglandin I2

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY). Molecular weight: 352.47 Formula: C20H32O5 CLOGP: 2.08 LIPINSKI: 0 HAC: 5 HDO: 3 TPSA: 86.99 ALOGS: -3.41 ROTB: 10 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 20, 1995	FDA	GLAXOSMITHKLINE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pain in jaw	3032.15	18.15	1315	65284	37113	50501412
Catheter site erythema	1912.80	18.15	527	66072	3435	50535090
Catheter management	1569.00	18.15	417	66182	2322	50536203
Catheter site pruritus	1426.39	18.15	362	66237	1625	50536900
Device related infection	1377.76	18.15	630	65969	20105	50518420
Flushing	1251.15	18.15	886	65713	66129	50472396
Right ventricular failure	1116.06	18.15	502	66097	15391	50523134
Catheter site discharge	1096.49	18.15	290	66309	1578	50536947
Catheter site pain	1082.64	18.15	335	66264	3427	50535098
Dyspnoea exertional	1010.83	18.15	701	65898	50532	50487993
Catheter site infection	978.65	18.15	320	66279	3966	50534559
Fluid retention	945.57	18.15	670	65929	49979	50488546
Dyspnoea	873.54	18.15	2093	64506	545515	49993010
Device leakage	842.55	18.15	310	66289	5568	50532957
Device alarm issue	779.03	18.15	208	66391	1180	50537345
Lung transplant	702.25	18.15	225	66374	2600	50535925
Drug ineffective	684.36	18.15	128	66471	819205	49719320
Catheter site haemorrhage	666.61	18.15	216	66383	2594	50535931
Hypervolaemia	665.90	18.15	416	66183	25083	50513442
Catheter placement	662.36	18.15	199	66400	1825	50536700
Central venous catheterisation	635.32	18.15	195	66404	1935	50536590
Catheter site rash	618.80	18.15	153	66446	602	50537923
Hospitalisation	603.24	18.15	584	66015	67353	50471172
Device occlusion	590.25	18.15	241	66358	5782	50532743
Catheter site swelling	535.81	18.15	154	66445	1190	50537335
Headache	526.78	18.15	1658	64941	504877	50033648
Pulmonary hypertension	486.45	18.15	381	66218	33036	50505489
Complication associated with device	443.88	18.15	263	66336	14392	50524133
Catheter site inflammation	414.33	18.15	109	66490	578	50537947
Diarrhoea	396.17	18.15	1673	64926	586803	49951722
Pulmonary arterial hypertension	365.37	18.15	263	66336	20056	50518469
Death	352.40	18.15	1082	65517	324297	50214228
Catheter site irritation	348.67	18.15	90	66509	437	50538088
Vascular device infection	334.88	18.15	147	66452	4237	50534288
Off label use	334.22	18.15	105	66494	474321	50064204
Device infusion issue	319.82	18.15	104	66495	1263	50537262
Therapy change	316.33	18.15	149	66450	5076	50533449
Transplant evaluation	311.68	18.15	96	66503	964	50537561
Device dislocation	299.15	18.15	239	66360	21307	50517218
Device breakage	298.70	18.15	175	66424	9372	50529153
Palpitations	297.64	18.15	483	66116	94023	50444502
Transfusion	283.60	18.15	189	66410	12716	50525809
Catheter site vesicles	246.27	18.15	61	66538	242	50538283
Oedema	236.42	18.15	370	66229	69811	50468714
Dermatitis contact	230.46	18.15	143	66456	8503	50530022
Toxicity to various agents	230.42	18.15	12	66587	212487	50326038
Paracentesis	227.80	18.15	73	66526	843	50537682
Ascites	219.33	18.15	253	66346	35608	50502917
Catheter site related reaction	216.85	18.15	68	66531	728	50537797
Emergency care	209.61	18.15	67	66532	767	50537758
Infusion related reaction	207.58	18.15	3	66596	169554	50368971
Pulmonary arterial pressure increased	201.20	18.15	95	66504	3253	50535272
Rheumatoid arthritis	200.52	18.15	18	66581	202532	50335993
Device connection issue	199.62	18.15	59	66540	508	50538017
Alopecia	193.44	18.15	43	66556	245004	50293521
Catheterisation cardiac	192.96	18.15	98	66501	3942	50534583
Hypoxia	192.62	18.15	284	66315	50839	50487686
Nausea	188.56	18.15	1574	65025	703824	49834701
Chest pain	185.95	18.15	583	66016	176299	50362226
Oxygen saturation decreased	180.37	18.15	336	66263	72912	50465613
Catheter removal	178.79	18.15	49	66550	311	50538214
Thrombosis in device	174.68	18.15	81	66518	2660	50535865
Drug interaction	172.44	18.15	28	66571	199593	50338932
Drug hypersensitivity	172.00	18.15	58	66541	250952	50287573
Device physical property issue	168.72	18.15	68	66531	1574	50536951
Joint swelling	165.77	18.15	58	66541	245228	50293297
Medical device change	165.10	18.15	45	66554	279	50538246
Device malfunction	164.98	18.15	146	66453	14975	50523550
Therapeutic product effect decreased	164.02	18.15	3	66596	136047	50402478
Arthropathy	161.88	18.15	12	66587	157894	50380631
Treatment failure	158.42	18.15	5	66594	137632	50400893
Neutropenia	158.32	18.15	9	66590	147956	50390569
Oxygen consumption increased	135.41	18.15	74	66525	3462	50535063
Central venous catheter removal	133.50	18.15	39	66560	321	50538204
Drug intolerance	126.89	18.15	65	66534	219039	50319486
Cardiac failure	126.45	18.15	297	66302	75743	50462782
Haemoptysis	124.78	18.15	161	66438	25412	50513113
Blood culture positive	124.38	18.15	75	66524	4233	50534292
Glossodynia	123.70	18.15	7	66592	115562	50422963
Catheter site scab	123.35	18.15	32	66567	159	50538366
Application site pruritus	123.12	18.15	71	66528	3688	50534837
Dyspnoea at rest	122.43	18.15	70	66529	3577	50534948
Hypertension	120.31	18.15	64	66535	211139	50327386
Musculoskeletal stiffness	117.93	18.15	15	66584	128466	50410059
Product use issue	116.31	18.15	27	66572	149448	50389077
Maternal exposure during pregnancy	112.75	18.15	35	66564	159743	50378782
Febrile neutropenia	110.77	18.15	4	66595	97663	50440862
Hepatic enzyme increased	110.56	18.15	23	66576	137357	50401168
Hypotension	110.30	18.15	605	65994	234864	50303661
Stomatitis	105.86	18.15	7	66592	101337	50437188
Skin irritation	105.69	18.15	85	66514	7642	50530883
Catheter site warmth	105.29	18.15	29	66570	188	50538337
Device related sepsis	104.23	18.15	62	66537	3413	50535112
Blood culture negative	102.88	18.15	26	66573	114	50538411
Device issue	100.99	18.15	128	66471	19844	50518681
Unevaluable event	100.69	18.15	201	66398	45865	50492660
Abdominal distension	98.36	18.15	263	66336	72640	50465885
Discomfort	96.26	18.15	14	66585	108366	50430159
Product use in unapproved indication	96.11	18.15	18	66581	115801	50422724
Oedema peripheral	94.46	18.15	435	66164	157526	50380999
Injection site pain	90.55	18.15	18	66581	111006	50427519
Nasal congestion	89.72	18.15	204	66395	50916	50487609
Heart and lung transplant	87.89	18.15	22	66577	92	50538433
Catheter site discolouration	87.32	18.15	22	66577	95	50538430
Weight decreased	87.05	18.15	543	66056	220702	50317823
Blood pressure increased	85.61	18.15	34	66565	133098	50405427
Catheter site cellulitis	85.34	18.15	25	66574	208	50538317
Staphylococcus test positive	84.90	18.15	54	66545	3352	50535173
Abdominal cavity drainage	84.64	18.15	28	66571	360	50538165
Scleroderma	83.65	18.15	61	66538	4740	50533785
Therapeutic product effect incomplete	83.20	18.15	11	66588	91504	50447021
Application site irritation	82.48	18.15	41	66558	1574	50536951
Gastritis hypertrophic	82.37	18.15	18	66581	34	50538491
Product administration interrupted	80.19	18.15	35	66564	994	50537531
Catheter culture positive	80.03	18.15	21	66578	110	50538415
Malaise	79.68	18.15	731	65868	334801	50203724
Intentional product use issue	75.60	18.15	7	66592	76911	50461614
Pulmonary veno-occlusive disease	75.45	18.15	33	66566	942	50537583
White blood cell count decreased	74.73	18.15	30	66569	116692	50421833
Transplant	74.04	18.15	29	66570	621	50537904
Hyperthyroidism	72.89	18.15	85	66514	12090	50526435
Pericarditis	72.64	18.15	9	66590	78680	50459845
Psoriasis	71.37	18.15	5	66594	68995	50469530
Disease progression	67.97	18.15	278	66321	95588	50442937
Confusional state	66.88	18.15	88	66511	185840	50352685
Wound	66.41	18.15	28	66571	105766	50432759
Depression	66.20	18.15	72	66527	165351	50373174
Drug abuse	66	18.15	3	66596	59843	50478682
Syncope	65.52	18.15	289	66310	102713	50435812
Osteoarthritis	65.44	18.15	7	66592	68599	50469926
Pneumonia	65.00	18.15	772	65827	377629	50160896
Inappropriate schedule of product administration	64.42	18.15	9	66590	71822	50466703
Leukopenia	64.13	18.15	7	66592	67521	50471004
Pericardial effusion	63.69	18.15	118	66481	25471	50513054
Investigation	63.66	18.15	34	66565	1518	50537007
Emergency care examination	63.29	18.15	15	66584	47	50538478
Aspiration pleural cavity	62.82	18.15	27	66572	738	50537787
Condition aggravated	61.98	18.15	630	65969	296428	50242097
Walking distance test abnormal	61.27	18.15	24	66575	514	50538011
Heart rate increased	61.21	18.15	232	66367	77018	50461507
Acute kidney injury	60.75	18.15	131	66468	227927	50310598
Cardiac ablation	60.66	18.15	31	66568	1263	50537262
Vomiting	60.45	18.15	895	65704	459863	50078662
Hypersensitivity	60.34	18.15	120	66479	215041	50323484
Impaired healing	59.72	18.15	10	66589	69776	50468749
Pulmonary oedema	59.49	18.15	170	66429	48768	50489757
Pain in extremity	59.48	18.15	584	66015	272281	50266244
Arthralgia	59.36	18.15	337	66262	438365	50100160
Oxygen therapy	58.74	18.15	34	66565	1778	50536747
Liver transplant	58.68	18.15	36	66563	2096	50536429
Application site erythema	58.02	18.15	48	66551	4490	50534035
Mobility decreased	57.29	18.15	17	66582	79931	50458594
Systemic lupus erythematosus	56.48	18.15	61	66538	140561	50397964
Somnolence	56.09	18.15	73	66526	154912	50383613
Infusion site infection	55.31	18.15	31	66568	1524	50537001
Pain	53.96	18.15	495	66104	578408	49960117
Coma	53.75	18.15	6	66593	56873	50481652
Injection site reaction	53.61	18.15	3	66596	50029	50488496
Injection site erythema	53.57	18.15	16	66583	74920	50463605
Presyncope	53.36	18.15	106	66493	24092	50514433
Clostridium difficile infection	53.19	18.15	109	66490	25330	50513195
Catheter site nodule	53.01	18.15	13	66586	49	50538476
Wrong technique in product usage process	52.09	18.15	6	66593	55504	50483021
Infusion site erythema	49.05	18.15	59	66540	8668	50529857
Gait disturbance	48.98	18.15	76	66523	149929	50388596
Acute right ventricular failure	48.66	18.15	15	66584	151	50538374
Duodenal ulcer perforation	48.06	18.15	3	66596	45608	50492917
Anaphylactic reaction	47.94	18.15	7	66592	54048	50484477
Electrocardiogram QT prolonged	47.72	18.15	6	66593	51880	50486645
Catheter site dermatitis	47.60	18.15	12	66587	52	50538473
Overdose	47.47	18.15	37	66562	99690	50438835
Suicidal ideation	47.25	18.15	8	66591	55377	50483148
Intentional product misuse	46.60	18.15	4	66595	46730	50491795
Platelet transfusion	46.22	18.15	21	66578	657	50537868
Decreased appetite	46.18	18.15	435	66164	200488	50338037
Blood potassium decreased	45.54	18.15	129	66470	36816	50501709
Application site hypersensitivity	45.33	18.15	15	66584	193	50538332
Suicide attempt	45.19	18.15	7	66592	51725	50486800
Catheter site extravasation	44.93	18.15	16	66583	260	50538265
Staphylococcal infection	44.53	18.15	125	66474	35491	50503034
Ventilation perfusion mismatch	43.98	18.15	15	66584	213	50538312
Catheter site induration	43.20	18.15	11	66588	50	50538475
Immunoglobulin G4 related disease	43.03	18.15	11	66588	51	50538474
Right ventricular dilatation	42.21	18.15	22	66577	934	50537591
Catheter site erosion	41.86	18.15	11	66588	58	50538467
Pulmonary haemorrhage	41.69	18.15	47	66552	6445	50532080
Hallucination	41.47	18.15	6	66593	46651	50491874
Disease complication	41.04	18.15	32	66567	2750	50535775
Dizziness	40.79	18.15	661	65938	345708	50192817
Catheter site hypersensitivity	40.73	18.15	12	66587	102	50538423
Pulmonary arterial pressure abnormal	40.34	18.15	17	66582	442	50538083
Seizure	40.14	18.15	58	66541	117816	50420709
Blood glucose increased	39.99	18.15	22	66577	71302	50467223
Pruritus	39.82	18.15	215	66384	283353	50255172
Injury	39.73	18.15	8	66591	48917	50489608
Epistaxis	39.55	18.15	178	66421	63776	50474749
Hypoglycaemia	39.11	18.15	11	66588	53570	50484955
Pancytopenia	38.95	18.15	32	66567	83998	50454527
Catheter site bruise	38.75	18.15	15	66584	311	50538214
Lower respiratory tract infection	38.54	18.15	41	66558	95160	50443365
Concomitant disease aggravated	37.99	18.15	50	66549	8041	50530484
Pulmonary embolism	37.72	18.15	47	66552	101657	50436868
Cardiac failure high output	37.64	18.15	14	66585	259	50538266
Cough	37.34	18.15	483	66116	240781	50297744
Depressed level of consciousness	37.30	18.15	11	66588	51942	50486583
Nasopharyngitis	37.25	18.15	403	66196	192524	50346001
Respiratory failure	37.15	18.15	226	66373	90955	50447570
Application site rash	36.71	18.15	28	66571	2329	50536196
Endotracheal intubation	36.69	18.15	27	66572	2127	50536398
Balance disorder	36.45	18.15	24	66575	70566	50467959
Myocardial infarction	36.42	18.15	38	66561	88989	50449536
Deep vein thrombosis	36.42	18.15	26	66573	73278	50465247
Therapeutic embolisation	36.22	18.15	12	66587	155	50538370
Hyponatraemia	36.10	18.15	44	66555	96095	50442430
Thyroidectomy	36.04	18.15	20	66579	964	50537561
Suture related complication	35.74	18.15	12	66587	162	50538363
Dysphagia	35.34	18.15	30	66569	77488	50461037
Catheter site oedema	35.15	18.15	9	66590	42	50538483
Lung assist device therapy	34.81	18.15	10	66589	77	50538448
Cognitive disorder	34.23	18.15	8	66591	44115	50494410
Catheter site urticaria	33.77	18.15	8	66591	25	50538500
Ear discomfort	33.73	18.15	43	66556	6701	50531824
First bite syndrome	33.67	18.15	7	66592	9	50538516
Abortion spontaneous	33.57	18.15	7	66592	41765	50496760
Catheter site dryness	33.08	18.15	8	66591	28	50538497
Cerebrovascular accident	32.81	18.15	46	66553	94634	50443891
C-reactive protein increased	32.47	18.15	24	66575	66450	50472075
Chest discomfort	32.36	18.15	221	66378	92501	50446024
Irritable bowel syndrome	31.66	18.15	14	66585	51427	50487098
Urticaria	31.57	18.15	78	66521	129483	50409042
Bacteraemia	31.55	18.15	63	66536	14370	50524155
Osteoporosis	31.32	18.15	10	66589	44869	50493656
Pulmonary alveolar haemorrhage	30.84	18.15	32	66567	3995	50534530
Mineral supplementation	30.62	18.15	16	66583	683	50537842
Atrial flutter	30.58	18.15	47	66552	8716	50529809
Blood pressure systolic increased	30.50	18.15	5	66594	35444	50503081
Dizziness postural	30.45	18.15	39	66560	6106	50532419
Biopsy liver	29.76	18.15	13	66586	370	50538155
Fibromyalgia	29.70	18.15	11	66588	44967	50493558
Infusion site pruritus	29.64	18.15	31	66568	3906	50534619
Catheter site thrombosis	29.51	18.15	10	66589	139	50538386
Hyperglycaemia	29.46	18.15	6	66593	36399	50502126
Bradycardia	29.28	18.15	25	66574	64401	50474124
Female sterilisation	29.05	18.15	14	66585	502	50538023
Congestive hepatopathy	29.05	18.15	25	66574	2469	50536056
Catheterisation cardiac abnormal	29.01	18.15	11	66588	215	50538310
Systemic-pulmonary artery shunt	28.84	18.15	7	66592	25	50538500
Paraesthesia	28.82	18.15	73	66526	120170	50418355
Device related thrombosis	28.36	18.15	19	66580	1288	50537237
Injection site pruritus	28.21	18.15	9	66590	40402	50498123
Caesarean section	28.08	18.15	63	66536	15576	50522949
Product deposit	27.94	18.15	10	66589	165	50538360
Hypoaesthesia	27.70	18.15	81	66518	127176	50411349
Sleep disorder	27.57	18.15	21	66578	57262	50481263
Right ventricular dysfunction	27.49	18.15	20	66579	1548	50536977
Loss of personal independence in daily activities	27.43	18.15	31	66568	70019	50468506
Urinary tract infection	27.11	18.15	178	66421	223842	50314683
Application site odour	26.95	18.15	7	66592	35	50538490
Concomitant disease progression	26.92	18.15	22	66577	2023	50536502
Knee arthroplasty	26.83	18.15	7	66592	35839	50502686
Tri-iodothyronine increased	26.77	18.15	9	66590	122	50538403
No adverse event	26.22	18.15	6	66593	33572	50504953
Balloon atrial septostomy	26.18	18.15	8	66591	78	50538447
Coronary artery disease	26.01	18.15	4	66595	29722	50508803
Echocardiogram abnormal	25.70	18.15	17	66582	1128	50537397
Culture positive	25.46	18.15	12	66587	409	50538116
Biopsy bone marrow	25.41	18.15	11	66588	306	50538219
Jugular vein distension	25.29	18.15	15	66584	821	50537704
Mechanical ventilation	25.16	18.15	17	66582	1169	50537356
Agitation	25.15	18.15	20	66579	53364	50485161
Tracheostomy	25.05	18.15	13	66586	547	50537978
Blood pressure fluctuation	24.97	18.15	8	66591	35815	50502710
Multiple allergies	24.89	18.15	42	66557	8421	50530104
Catheter site abscess	24.81	18.15	6	66593	21	50538504
Emotional distress	24.76	18.15	4	66595	28659	50509866
Swollen tongue	24.72	18.15	4	66595	28626	50509899
General physical health deterioration	24.67	18.15	100	66499	142334	50396191
Hospice care	24.56	18.15	34	66565	5738	50532787
Cholecystectomy	24.54	18.15	44	66555	9259	50529266
Tremor	24.38	18.15	74	66525	114829	50423696
Terminal state	24.27	18.15	21	66578	2089	50536436
Urinary retention	24.15	18.15	3	66596	26187	50512338
Asthma	24.01	18.15	51	66548	89286	50449239
Biopsy lymph gland	23.61	18.15	6	66593	27	50538498
Orthostatic hypotension	23.56	18.15	5	66594	29476	50509049
Disturbance in attention	23.52	18.15	6	66593	31180	50507345
Therapeutic procedure	23.49	18.15	14	66585	773	50537752
Femur fracture	23.36	18.15	10	66589	37454	50501071
Cardioversion	23.31	18.15	16	66583	1129	50537396
Contusion	23.27	18.15	73	66526	112110	50426415
Infusion site rash	23.26	18.15	17	66582	1325	50537200
Dry mouth	22.95	18.15	24	66575	56154	50482371
Arthritis	22.90	18.15	50	66549	86671	50451854
Application site reaction	22.79	18.15	13	66586	661	50537864
Oral pain	22.76	18.15	3	66596	25030	50513495
Upper respiratory tract congestion	22.66	18.15	19	66580	1810	50536715
Lactic acidosis	22.29	18.15	8	66591	33347	50505178
Stent placement	22.26	18.15	25	66574	3413	50535112
Hypokalaemia	22.20	18.15	52	66547	87940	50450585
Cardiac output increased	22.08	18.15	8	66591	137	50538388
Drug-induced liver injury	21.98	18.15	5	66594	28090	50510435
Blister	21.94	18.15	50	66549	85368	50453157
Myalgia	21.84	18.15	255	66344	124064	50414461
Metabolic acidosis	21.72	18.15	12	66587	38813	50499712
Vertigo	21.33	18.15	22	66577	51810	50486715
Brain natriuretic peptide increased	21.29	18.15	28	66571	4499	50534026
Dysentery	21.17	18.15	13	66586	758	50537767
Delirium	21.09	18.15	12	66587	38180	50500345
Dry eye	20.94	18.15	8	66591	32087	50506438
Cardiac flutter	20.85	18.15	24	66575	3366	50535159
Endarterectomy	20.84	18.15	8	66591	162	50538363
Acute respiratory failure	20.80	18.15	84	66515	28698	50509827
Pulmonary artery dilatation	20.77	18.15	9	66590	251	50538274
Therapeutic response decreased	20.65	18.15	19	66580	47212	50491313
Insomnia	20.61	18.15	140	66459	174725	50363800
Angioedema	20.57	18.15	12	66587	37664	50500861
Aphasia	20.51	18.15	6	66593	28488	50510037
Adrenocorticotropic hormone deficiency	20.51	18.15	9	66590	259	50538266
Suture insertion	20.42	18.15	7	66592	101	50538424
Catheter site mass	20.35	18.15	5	66594	19	50538506
Culture negative	20.30	18.15	4	66595	3	50538522
Catheter site scar	20.30	18.15	4	66595	3	50538522
Muscular weakness	20.29	18.15	61	66538	94952	50443573
Supraventricular tachycardia	20.17	18.15	49	66550	12752	50525773
Speech disorder	19.87	18.15	11	66588	35537	50502988
Dyskinesia	19.81	18.15	6	66593	27855	50510670
N-terminal prohormone brain natriuretic peptide increased	19.63	18.15	17	66582	1693	50536832
Drain placement	19.59	18.15	6	66593	59	50538466
Hepatocellular injury	19.55	18.15	5	66594	25942	50512583
Pituitary enlargement	19.42	18.15	5	66594	24	50538501
Chronic right ventricular failure	19.42	18.15	5	66594	24	50538501
Inflammation	19.37	18.15	28	66571	56884	50481641
Cardiac output decreased	19.33	18.15	13	66586	887	50537638
Pulmonary capillary haemangiomatosis	19.25	18.15	5	66594	25	50538500
Infusion site pain	19.18	18.15	47	66552	12299	50526226
Visual impairment	19.17	18.15	38	66561	68237	50470288
Cardiac disorder	19.09	18.15	109	66490	42870	50495655
Cholestasis	18.94	18.15	5	66594	25396	50513129
Diabetes mellitus	18.87	18.15	22	66577	49011	50489514
Biopsy skin	18.82	18.15	6	66593	68	50538457
Irritability	18.69	18.15	7	66592	28419	50510106
Plasma cell myeloma	18.53	18.15	9	66590	31313	50507212
Right atrial dilatation	18.51	18.15	11	66588	604	50537921
Silent thyroiditis	18.51	18.15	6	66593	72	50538453
Cor pulmonale	18.19	18.15	17	66582	1870	50536655

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pain in jaw	1063.13	24.88	354	16548	11287	29546338
Catheter management	604.15	24.88	131	16771	713	29556912
Catheter site erythema	468.96	24.88	114	16788	1097	29556528
Right ventricular failure	459.66	24.88	172	16730	7718	29549907
Fluid retention	400.92	24.88	217	16685	23343	29534282
Device related infection	361.31	24.88	177	16725	15459	29542166
Catheter site pruritus	342.67	24.88	69	16833	242	29557383
Device alarm issue	299.58	24.88	69	16833	513	29557112
Lung transplant	293.54	24.88	85	16817	1671	29555954
Catheter placement	287.90	24.88	69	16833	621	29557004
Headache	264.55	24.88	404	16498	173603	29384022
Dyspnoea	262.98	24.88	575	16327	326157	29231468
Device occlusion	257.91	24.88	103	16799	5505	29552120
Flushing	252.47	24.88	174	16728	28818	29528807
Catheter site discharge	223.14	24.88	54	16848	508	29557117
Catheter site infection	222.34	24.88	71	16831	1961	29555664
Hypervolaemia	213.55	24.88	130	16772	17415	29540210
Dyspnoea exertional	206.11	24.88	169	16733	36321	29521304
Catheter site pain	197.45	24.88	57	16845	1107	29556518
Pulmonary hypertension	179.37	24.88	119	16783	18489	29539136
Device dislocation	176.90	24.88	74	16828	4453	29553172
Complication associated with device	176.87	24.88	77	16825	5114	29552511
Catheter site haemorrhage	165.75	24.88	57	16845	1991	29555634
Central venous catheterisation	159.25	24.88	47	16855	989	29556636
Catheter site rash	149.76	24.88	32	16870	160	29557465
Device leakage	144.47	24.88	64	16838	4431	29553194
Pulmonary arterial hypertension	124.80	24.88	68	16834	7381	29550244
Oxygen saturation decreased	123.49	24.88	140	16762	44797	29512828
Hospitalisation	115.85	24.88	137	16765	45851	29511774
Catheter removal	110.84	24.88	25	16877	167	29557458
Catheter site inflammation	108.14	24.88	25	16877	189	29557436
Catheter site irritation	104.86	24.88	22	16880	99	29557526
Medical device change	102.90	24.88	21	16881	80	29557545
Transplant evaluation	101.53	24.88	28	16874	457	29557168
Drug interaction	95.80	24.88	4	16898	197381	29360244
Catheter site swelling	94.55	24.88	24	16878	279	29557346
Paracentesis	92.24	24.88	25	16877	381	29557244
Pulmonary veno-occlusive disease	89.70	24.88	25	16877	425	29557200
Device infusion issue	86.39	24.88	26	16876	586	29557039
Thrombosis in device	85.71	24.88	40	16862	3124	29554501
Toxicity to various agents	79.57	24.88	5	16897	173656	29383969
Therapy change	77.12	24.88	35	16867	2563	29555062
Pain in extremity	76.43	24.88	184	16718	110249	29447376
Condition aggravated	76.04	24.88	219	16683	146076	29411549
Oedema	75.64	24.88	104	16798	40379	29517246
Ascites	74.41	24.88	98	16804	36521	29521104
Device connection issue	73.66	24.88	20	16882	307	29557318
Transfusion	73.50	24.88	48	16854	7250	29550375
Device breakage	73.32	24.88	30	16872	1704	29555921
Vascular device infection	72.01	24.88	33	16869	2472	29555153
Heart and lung transplant	71.77	24.88	15	16887	66	29557559
Blood culture positive	63.68	24.88	37	16865	4540	29553085
Neutropenia	62.76	24.88	3	16899	131708	29425917
Hypoxia	61.86	24.88	103	16799	47276	29510349
Death	61.16	24.88	368	16534	341716	29215909
Concomitant disease aggravated	60.80	24.88	37	16865	4941	29552684
Device physical property issue	60.25	24.88	20	16882	625	29557000
Diarrhoea	58.88	24.88	357	16545	332341	29225284
Oxygen consumption increased	56.93	24.88	23	16879	1264	29556361
Abdominal distension	56.21	24.88	97	16805	45814	29511811
Catheterisation cardiac	54.57	24.88	26	16876	2127	29555498
Pulmonary arterial pressure increased	53.59	24.88	21	16881	1065	29556560
Device malfunction	53.47	24.88	42	16860	8465	29549160
Drug ineffective	52.74	24.88	79	16823	363091	29194534
Product deposit	52.50	24.88	15	16887	280	29557345
Febrile neutropenia	52.07	24.88	3	16899	112237	29445388
Haemoptysis	51.88	24.88	75	16827	30475	29527150
Off label use	50.19	24.88	59	16843	300741	29256884
Liver transplant	49.80	24.88	25	16877	2291	29555334
Device related sepsis	48.04	24.88	25	16877	2470	29555155
Catheter site vesicles	46.27	24.88	9	16893	25	29557600
Blood culture negative	40.67	24.88	8	16894	24	29557601
Device issue	37.62	24.88	33	16869	7747	29549878
Nausea	37.08	24.88	287	16615	288968	29268657
Cardiac failure	36.63	24.88	114	16788	79173	29478452
Dermatitis contact	35.92	24.88	22	16880	2970	29554655
Oxygen therapy	35.83	24.88	14	16888	704	29556921
Catheter site scab	33.73	24.88	6	16896	8	29557617
Palpitations	33.67	24.88	64	16838	32540	29525085
Abdominal cavity drainage	33.44	24.88	11	16891	334	29557291
Pulmonary endarterectomy	33.27	24.88	8	16894	73	29557552
Spinal cord ischaemia	33.07	24.88	8	16894	75	29557550
Micrococcus test positive	32.57	24.88	6	16896	11	29557614
Pulmonary oedema	32.53	24.88	74	16828	42661	29514964
White blood cell count decreased	31.42	24.88	5	16897	83357	29474268
Catheter culture positive	30.50	24.88	6	16896	18	29557607
Catheter site dermatitis	29.99	24.88	5	16897	3	29557622
Catheter site dryness	29.99	24.88	5	16897	3	29557622
Catheter site mass	29.80	24.88	6	16896	21	29557604
Oedema peripheral	29.29	24.88	127	16775	103430	29454195
Catheter site related reaction	28.12	24.88	9	16893	250	29557375
Central venous catheter removal	27.75	24.88	6	16896	32	29557593
Disease progression	27.55	24.88	106	16796	81810	29475815
Catheter site extravasation	27.29	24.88	7	16895	85	29557540
Epistaxis	26.36	24.88	77	16825	51627	29505998
Nasal congestion	25.90	24.88	42	16860	18837	29538788
Overdose	25.54	24.88	7	16895	79812	29477813
Catheter site warmth	25.23	24.88	6	16896	52	29557573
Myocardial infarction	25.16	24.88	16	16886	110280	29447345
Staphylococcus test positive	25.15	24.88	17	16885	2716	29554909
Balloon atrial septostomy	24.94	24.88	5	16897	17	29557608

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pain in jaw	3603.22	18.49	1469	75284	39286	64382693
Catheter site erythema	2106.52	18.49	581	76172	4268	64417711
Catheter management	1848.38	18.49	485	76268	2870	64419109
Catheter site pruritus	1579.36	18.49	391	76362	1757	64420222
Device related infection	1527.71	18.49	740	76013	29886	64392093
Right ventricular failure	1388.28	18.49	621	76132	20850	64401129
Flushing	1350.05	18.49	950	75803	77698	64344281
Fluid retention	1224.91	18.49	805	75948	58801	64363178
Catheter site discharge	1200.95	18.49	317	76436	1924	64420055
Catheter site pain	1143.02	18.49	355	76398	4107	64417872
Catheter site infection	1069.89	18.49	358	76395	5335	64416644
Dyspnoea exertional	991.07	18.49	769	75984	72961	64349018
Dyspnoea	987.83	18.49	2438	74315	716236	63705743
Device alarm issue	963.48	18.49	257	76496	1633	64420346
Device leakage	932.24	18.49	356	76397	7910	64414069
Catheter placement	883.04	18.49	257	76496	2336	64419643
Lung transplant	862.85	18.49	281	76472	3827	64418152
Headache	788.04	18.49	1855	74898	527612	63894367
Hypervolaemia	776.10	18.49	513	76240	37772	64384207
Device occlusion	728.81	18.49	314	76439	9599	64412380
Central venous catheterisation	722.73	18.49	223	76530	2518	64419461
Catheter site haemorrhage	719.37	18.49	252	76501	4339	64417640
Catheter site rash	666.62	18.49	167	76586	794	64421185
Complication associated with device	597.48	18.49	312	76441	14768	64407211
Pulmonary hypertension	572.75	18.49	447	76306	42692	64379287
Catheter site swelling	565.84	18.49	164	76589	1466	64420513
Hospitalisation	552.33	18.49	557	76196	74650	64347329
Drug ineffective	503.72	18.49	187	76566	840060	63581919
Catheter site inflammation	484.01	18.49	129	76624	816	64421163
Device dislocation	439.24	18.49	288	76465	20890	64401089
Diarrhoea	420.42	18.49	1833	74920	720871	63701108
Pulmonary arterial hypertension	410.41	18.49	296	76457	25071	64396908
Device breakage	389.81	18.49	196	76557	8559	64413420
Death	375.93	18.49	1343	75410	481362	63940617
Device infusion issue	372.16	18.49	121	76632	1637	64420342
Catheter site irritation	367.33	18.49	93	76660	465	64421514
Toxicity to various agents	364.96	18.49	16	76737	363497	64058482
Off label use	360.17	18.49	152	76601	632654	63789325
Transplant evaluation	332.99	18.49	108	76645	1449	64420530
Drug interaction	330.15	18.49	27	76726	362056	64059923
Transfusion	309.54	18.49	218	76535	17776	64404203
Palpitations	308.57	18.49	491	76262	103997	64317982
Oedema	288.09	18.49	444	76309	91491	64330488
Paracentesis	284.25	18.49	91	76662	1168	64420811
Vascular device infection	274.08	18.49	138	76615	6042	64415937
Therapy change	271.72	18.49	139	76614	6295	64415684
Nausea	267.39	18.49	1720	75033	784080	63637899
Dermatitis contact	262.05	18.49	152	76601	8848	64413131
Catheter removal	246.50	18.49	68	76685	498	64421481
Neutropenia	242.14	18.49	10	76743	239614	64182365
Oxygen saturation decreased	240.55	18.49	446	76307	106730	64315249
Catheter site vesicles	238.03	18.49	59	76694	266	64421713
Medical device change	237.82	18.49	64	76689	422	64421557
Thrombosis in device	235.98	18.49	117	76636	4954	64417025
Ascites	225.16	18.49	321	76432	61680	64360299
Catheterisation cardiac	222.53	18.49	111	76642	4762	64417217
Catheter site related reaction	221.29	18.49	71	76682	918	64421061
Device connection issue	221.13	18.49	69	76684	810	64421169
Device physical property issue	209.03	18.49	83	76670	2050	64419929
Device malfunction	208.88	18.49	171	76582	17462	64404517
Pulmonary arterial pressure increased	206.59	18.49	100	76653	4016	64417963
Emergency care	205.17	18.49	66	76687	861	64421118
Febrile neutropenia	192.38	18.49	7	76746	187650	64234329
Hypoxia	184.32	18.49	356	76397	87793	64334186
Infusion related reaction	176.39	18.49	4	76749	164463	64257516
Blood culture positive	165.53	18.49	108	76645	7760	64414219
Chest pain	159.05	18.49	628	76125	235352	64186627
Oxygen consumption increased	153.97	18.49	85	76668	4496	64417483
Central venous catheter removal	145.72	18.49	42	76711	367	64421612
Device related sepsis	144.62	18.49	85	76668	5070	64416909
Acute kidney injury	139.68	18.49	199	76554	449041	63972938
Catheter site scab	138.56	18.49	35	76718	173	64421806
Device issue	137.99	18.49	152	76601	22496	64399483
Rheumatoid arthritis	137.20	18.49	17	76736	164277	64257702
Heart and lung transplant	135.80	18.49	34	76719	161	64421818
Drug abuse	135.43	18.49	5	76748	132369	64289610
Application site pruritus	133.81	18.49	71	76682	3468	64418511
Abdominal distension	131.44	18.49	327	76426	95667	64326312
Blood culture negative	130.66	18.49	33	76720	163	64421816
Haemoptysis	127.80	18.49	218	76535	48830	64373149
Pulmonary veno-occlusive disease	127.61	18.49	52	76701	1376	64420603
Hypertension	126.39	18.49	76	76677	259185	64162794
Product use in unapproved indication	123.95	18.49	29	76724	176589	64245390
Therapeutic product effect decreased	122.91	18.49	3	76750	115348	64306631
Drug hypersensitivity	121.22	18.49	66	76687	237749	64184230
Unevaluable event	116.81	18.49	213	76540	50276	64371703
Catheter site warmth	115.68	18.49	32	76721	237	64421742
Oedema peripheral	113.22	18.49	523	76230	209794	64212185
Skin irritation	110.64	18.49	90	76663	9104	64412875
Treatment failure	108.28	18.49	8	76745	116808	64305171
Stomatitis	106.06	18.49	6	76747	109599	64312380
Pain in extremity	105.00	18.49	668	76085	302417	64119562
Condition aggravated	104.87	18.49	780	75973	371646	64050333
Arthropathy	104.78	18.49	11	76742	120956	64301023
Malaise	102.73	18.49	814	75939	395433	64026546
Dyspnoea at rest	102.65	18.49	74	76679	6255	64415724
Abdominal cavity drainage	102.64	18.49	37	76716	694	64421285
Nasal congestion	102.24	18.49	222	76531	59436	64362543
Catheter culture positive	100.59	18.49	27	76726	176	64421803
Cardiac failure	98.68	18.49	364	76389	132009	64289970
Application site irritation	96.72	18.49	44	76709	1532	64420447
Staphylococcus test positive	96.15	18.49	68	76685	5577	64416402
White blood cell count decreased	95.87	18.49	34	76719	157803	64264176
Joint swelling	94.39	18.49	71	76682	215311	64206668
Scleroderma	93.76	18.49	63	76690	4755	64417224
Alopecia	93.52	18.49	40	76713	165650	64256329
Confusional state	93.20	18.49	104	76649	261040	64160939
Hepatic enzyme increased	91.82	18.49	21	76732	129922	64292057
Product use issue	89.91	18.49	34	76719	151681	64270298
Musculoskeletal stiffness	88.90	18.49	19	76734	123187	64298792
Leukopenia	88.21	18.49	9	76744	101233	64320746
Overdose	84.66	18.49	42	76711	159524	64262455
Gastritis hypertrophic	84.18	18.49	18	76735	34	64421945
Weight decreased	83.51	18.49	604	76149	285135	64136844
Catheter site discolouration	82.61	18.49	21	76732	107	64421872
Catheter site cellulitis	81.03	18.49	27	76726	396	64421583
Liver transplant	80.81	18.49	54	76699	4038	64417941
Injection site pain	80.75	18.49	17	76736	111391	64310588
Blood pressure increased	80.71	18.49	53	76700	172499	64249480
Myocardial infarction	78.83	18.49	50	76703	165771	64256208
Pancytopenia	78.66	18.49	36	76717	143273	64278706
Coma	78.42	18.49	7	76746	87608	64334371
Infusion site infection	78.13	18.49	38	76715	1542	64420437
Intentional product use issue	76.88	18.49	11	76742	95353	64326626
Inappropriate schedule of product administration	75.92	18.49	10	76743	92276	64329703
Transplant	75.15	18.49	31	76722	847	64421132
Somnolence	74.96	18.49	79	76674	203566	64218413
Therapeutic product effect incomplete	74.57	18.49	16	76737	103466	64318513
Heart rate increased	74.07	18.49	272	76481	98403	64323576
Product administration interrupted	73.74	18.49	33	76720	1105	64420874
Investigation	73.53	18.49	41	76712	2211	64419768
Oxygen therapy	72.84	18.49	41	76712	2252	64419727
Pulmonary oedema	72.28	18.49	232	76521	78442	64343537
Disease progression	72.27	18.49	347	76406	141333	64280646
Electrocardiogram QT prolonged	72.05	18.49	6	76747	79442	64342537
Hyperthyroidism	71.73	18.49	98	76655	18081	64403898
Product deposit	70.63	18.49	24	76729	375	64421604
Infusion site erythema	69.77	18.49	61	76692	6812	64415167
Concomitant disease aggravated	69.50	18.49	77	76676	11465	64410514
Catheter site dermatitis	69.25	18.49	17	76736	73	64421906
Cardiac ablation	68.27	18.49	36	76717	1736	64420243
Hypotension	67.81	18.49	722	76031	380252	64041727
Vomiting	67.33	18.49	973	75780	550144	63871835
Drug intolerance	66.89	18.49	75	76678	187917	64234062
Psoriasis	66.18	18.49	5	76748	71698	64350281
Pericardial effusion	66.02	18.49	145	76608	39109	64382870
Catheter site extravasation	64.26	18.49	22	76731	352	64421627
Hyponatraemia	63.56	18.49	50	76703	148289	64273690
Aspiration pleural cavity	63.49	18.49	32	76721	1403	64420576
Hypoglycaemia	62.56	18.49	15	76738	89877	64332102
Hallucination	62.05	18.49	7	76746	72781	64349198
Application site erythema	60.89	18.49	48	76705	4641	64417338
Walking distance test abnormal	60.26	18.49	25	76728	693	64421286
Blood glucose increased	59.75	18.49	21	76732	98052	64323927
Intentional product misuse	59.07	18.49	8	76745	72287	64349692
Emergency care examination	57.63	18.49	14	76739	57	64421922
Nasopharyngitis	56.94	18.49	414	76339	195659	64226320
Depression	56.02	18.49	82	76671	183209	64238770
Suicide attempt	55.38	18.49	9	76744	70998	64350981
Anaphylactic reaction	55.16	18.49	8	76745	68656	64353323
Syncope	54.81	18.49	348	76405	157287	64264692
Blood creatine phosphokinase increased	54.28	18.49	4	76749	58554	64363425
Deep vein thrombosis	53.82	18.49	29	76724	105153	64316826
Pulmonary embolism	53.59	18.49	57	76696	146299	64275680
Wrong technique in product usage process	53.54	18.49	7	76746	64967	64357012
Catheter site dryness	53.00	18.49	12	76741	33	64421946
Mobility decreased	52.95	18.49	18	76735	85822	64336157
Metabolic acidosis	51.06	18.49	11	76742	70947	64351032
Glossodynia	50.91	18.49	8	76745	64688	64357291
Injection site erythema	50.89	18.49	11	76742	70789	64351190
Thyroidectomy	50.85	18.49	23	76730	790	64421189
Bradycardia	50.44	18.49	40	76713	118179	64303800
Drug reaction with eosinophilia and systemic symptoms	49.42	18.49	4	76749	54213	64367766
Hyperglycaemia	49.21	18.49	7	76746	60961	64361018
Epistaxis	49.05	18.49	239	76514	97892	64324087
Depressed level of consciousness	48.65	18.49	18	76735	81418	64340561
Coronary artery disease	48.64	18.49	7	76746	60426	64361553
Pericarditis	48.58	18.49	8	76745	62508	64359471
Presyncope	48.47	18.49	120	76633	34969	64387010
Discomfort	48.11	18.49	18	76735	80860	64341119
Seizure	47.80	18.49	78	76675	166814	64255165
Osteoarthritis	47.27	18.49	9	76744	63327	64358652
Application site rash	46.51	18.49	29	76724	1925	64420054
Suicidal ideation	46.50	18.49	11	76742	66531	64355448
Gait disturbance	46.07	18.49	84	76669	172071	64249908
Lung assist device therapy	45.90	18.49	13	76740	106	64421873
Dysphagia	45.75	18.49	36	76717	106776	64315203
Agitation	45.74	18.49	24	76729	88343	64333636
Balloon atrial septostomy	45.58	18.49	13	76740	109	64421870
Blood potassium decreased	45.46	18.49	128	76625	40271	64381708
Immunoglobulin G4 related disease	45.37	18.49	13	76740	111	64421868
Dizziness	45.32	18.49	741	76012	429422	63992557
Catheter site induration	45.24	18.49	11	76742	45	64421934
Multiple allergies	44.33	18.49	44	76709	5770	64416209
Acute myocardial infarction	44.08	18.49	14	76739	69704	64352275
Tri-iodothyronine increased	44.06	18.49	14	76739	175	64421804
Catheter site mass	43.95	18.49	11	76742	52	64421927
Hyperkalaemia	43.42	18.49	34	76719	101095	64320884
Lactic acidosis	43.21	18.49	10	76743	61400	64360579
Cardiac failure high output	43.14	18.49	15	76738	252	64421727
Maternal exposure during pregnancy	42.75	18.49	31	76722	95853	64326126
Suture related complication	42.39	18.49	15	76738	266	64421713
Pulmonary arterial pressure abnormal	42.02	18.49	19	76734	652	64421327
Delirium	41.83	18.49	15	76738	69179	64352800
Hypersensitivity	41.71	18.49	109	76644	196343	64225636
Clostridium difficile infection	41.11	18.49	115	76638	36048	64385931
Acute right ventricular failure	40.95	18.49	15	76738	295	64421684
Staphylococcal infection	40.82	18.49	143	76610	50535	64371444
Cognitive disorder	40.75	18.49	8	76745	55079	64366900
Psoriatic arthropathy	39.99	18.49	3	76750	43278	64378701
Angioedema	39.83	18.49	12	76741	61809	64360170
Disease complication	39.68	18.49	36	76717	4219	64417760
Catheter site nodule	39.66	18.49	10	76743	49	64421930
Blood pressure systolic increased	39.17	18.49	6	76747	49447	64372532
Catheter site urticaria	38.93	18.49	9	76744	28	64421951
Cerebrovascular accident	38.74	18.49	65	76688	137518	64284461
Impaired healing	38.49	18.49	12	76741	60461	64361518
Infusion site rash	38.49	18.49	21	76732	1085	64420894
Application site hypersensitivity	38.28	18.49	14	76739	274	64421705
Aggression	38.04	18.49	5	76748	46227	64375752
Catheter site bruise	38.00	18.49	14	76739	280	64421699
Infusion site pain	37.95	18.49	54	76699	10343	64411636
Sedation	37.95	18.49	3	76750	41459	64380520
Catheter site hypersensitivity	37.88	18.49	11	76742	99	64421880
Injury	37.69	18.49	10	76743	55982	64365997
Balance disorder	37.59	18.49	27	76726	83899	64338080
Blood pressure fluctuation	37.40	18.49	8	76745	51863	64370116
Pneumonia	37.39	18.49	900	75853	558676	63863303
Therapeutic procedure	37.27	18.49	18	76735	719	64421260
Cough	36.97	18.49	534	76219	301614	64120365
Hepatocellular injury	36.96	18.49	5	76748	45230	64376749
Urinary retention	36.70	18.49	7	76746	49194	64372785
Cholestasis	36.57	18.49	5	76748	44867	64377112
Orthostatic hypotension	36.27	18.49	6	76747	46732	64375247
Platelet transfusion	36.00	18.49	24	76729	1787	64420192
Biopsy bone marrow	35.90	18.49	14	76739	329	64421650
General physical health deterioration	35.80	18.49	124	76629	204301	64217678
Catheter site oedema	35.36	18.49	10	76743	81	64421898
Injection site swelling	35.18	18.49	4	76749	41349	64380630
Drug-induced liver injury	35.07	18.49	7	76746	47636	64374343
Disturbance in attention	34.88	18.49	4	76749	41070	64380909
C-reactive protein increased	34.69	18.49	37	76716	94872	64327107
Infusion site pruritus	34.54	18.49	27	76726	2579	64419400
Helicobacter infection	34.50	18.49	3	76750	38359	64383620
Agranulocytosis	34.35	18.49	3	76750	38226	64383753
Cholecystectomy	34.28	18.49	45	76708	7987	64413992
Hypokalaemia	33.94	18.49	58	76695	121845	64300134
Catheter site erosion	33.10	18.49	9	76744	62	64421917
Ear discomfort	32.97	18.49	42	76711	7238	64414741
Tracheostomy	32.82	18.49	19	76734	1101	64420878
Dysarthria	32.46	18.49	15	76738	59391	64362588
Congestive hepatopathy	32.03	18.49	31	76722	3942	64418037
Cardiac output increased	31.68	18.49	11	76742	184	64421795
Catheter site thrombosis	31.57	18.49	11	76742	186	64421793
Chest tube insertion	31.40	18.49	10	76743	126	64421853
Catheterisation cardiac abnormal	31.01	18.49	12	76741	276	64421703
Right ventricular dilatation	30.80	18.49	20	76733	1425	64420554
Dyskinesia	30.69	18.49	5	76748	39383	64382596
Endotracheal intubation	30.67	18.49	30	76723	3865	64418114
Interstitial lung disease	30.55	18.49	43	76710	97689	64324290
Haematuria	30.45	18.49	17	76736	60454	64361525
Duodenal ulcer perforation	30.35	18.49	3	76750	34622	64387357
Mineral supplementation	30.35	18.49	16	76737	771	64421208
Ventilation perfusion mismatch	30.16	18.49	12	76741	298	64421681
Wound	30.03	18.49	28	76725	76449	64345530
Retching	29.89	18.49	60	76693	15196	64406783
Drug level increased	29.88	18.49	3	76750	34193	64387786
Pulmonary capillary haemangiomatosis	29.82	18.49	8	76745	52	64421927
Right ventricular dysfunction	29.57	18.49	23	76730	2180	64419799
Endarterectomy	29.54	18.49	12	76741	315	64421664
Catheter site granuloma	29.44	18.49	8	76745	55	64421924
Biopsy liver	29.25	18.49	14	76739	548	64421431
Urticaria	28.83	18.49	85	76668	147232	64274747
Blood lactate dehydrogenase increased	28.65	18.49	3	76750	33075	64388904
Arthralgia	28.63	18.49	363	76390	441897	63980082
Dysentery	28.47	18.49	16	76737	876	64421103
Therapeutic embolisation	28.43	18.49	13	76740	458	64421521
Drug resistance	28.40	18.49	4	76749	35098	64386881
Brain natriuretic peptide increased	28.39	18.49	40	76713	7593	64414386
Drug delivery system malfunction	28.33	18.49	13	76740	462	64421517
Decreased appetite	28.25	18.49	481	76272	280808	64141171
Swollen tongue	28.24	18.49	4	76749	34950	64387029
Pruritus	28.18	18.49	237	76516	312163	64109816
Micrococcus test positive	28.18	18.49	6	76747	11	64421968
Mechanical ventilation	28.02	18.49	23	76730	2355	64419624
Mouth ulceration	27.95	18.49	3	76750	32441	64389538
Goitre	27.93	18.49	32	76721	4941	64417038
Caesarean section	27.90	18.49	49	76704	11225	64410754
Plasma cell myeloma	27.83	18.49	10	76743	46065	64375914
Seasonal allergy	27.78	18.49	50	76703	11676	64410303
Chest discomfort	27.51	18.49	234	76519	115872	64306107
Systemic-pulmonary artery shunt	27.48	18.49	7	76746	36	64421943
Pulmonary haemorrhage	27.43	18.49	53	76700	13056	64408923
Renal impairment	27.08	18.49	77	76676	134940	64287039
Hospice care	26.95	18.49	39	76714	7586	64414393
Paraesthesia	26.77	18.49	77	76676	134445	64287534
Epilepsy	26.71	18.49	4	76749	33527	64388452
Tremor	26.56	18.49	89	76664	148141	64273838
Diabetes mellitus	26.50	18.49	24	76729	66450	64355529
Cerebral infarction	26.38	18.49	8	76745	41036	64380943
Silent thyroiditis	26.29	18.49	9	76744	144	64421835
Infusion site discharge	26.24	18.49	13	76740	549	64421430
Cardioversion	26.00	18.49	20	76733	1865	64420114
Culture positive	25.88	18.49	16	76737	1046	64420933
Colonoscopy	25.73	18.49	19	76734	1666	64420313
Hepatitis	25.70	18.49	11	76742	45571	64376408
Biopsy lymph gland	25.63	18.49	8	76745	94	64421885
Lower respiratory tract infection	25.44	18.49	46	76707	94568	64327411
COVID-19	25.40	18.49	24	76729	65116	64356863
Blood creatinine increased	25.39	18.49	80	76673	135702	64286277
Hypocalcaemia	25.32	18.49	9	76744	41744	64380235
Liver injury	25.20	18.49	3	76750	29929	64392050
Diabetic ketoacidosis	25.11	18.49	3	76750	29842	64392137
Altered state of consciousness	25.07	18.49	7	76746	37895	64384084
Asthma	24.98	18.49	47	76706	95178	64326801
Encephalopathy	24.96	18.49	20	76733	58799	64363180
Cor pulmonale	24.74	18.49	20	76733	2005	64419974
Abnormal behaviour	24.62	18.49	5	76748	33617	64388362
Disease recurrence	24.55	18.49	4	76749	31506	64390473
Hypomagnesaemia	24.54	18.49	7	76746	37369	64384610
Muscular weakness	24.53	18.49	74	76679	127264	64294715
Feeling abnormal	24.52	18.49	255	76498	133347	64288632
Sleep disorder	24.47	18.49	21	76732	59688	64362291
Ischaemic stroke	24.23	18.49	3	76750	29032	64392947
Device related thrombosis	24.22	18.49	20	76733	2065	64419914
Atrial septal defect repair	24.13	18.49	11	76742	385	64421594
Hepatic steatosis	24.02	18.49	4	76749	31003	64390976
Jaundice	23.91	18.49	14	76739	48498	64373481
Application site odour	23.86	18.49	6	76747	29	64421950
Catheter site abscess	23.86	18.49	6	76747	29	64421950
Dry mouth	23.86	18.49	22	76731	60396	64361583
First bite syndrome	23.70	18.49	6	76747	30	64421949
Cardiac flutter	23.60	18.49	27	76726	4162	64417817
Sinus disorder	23.54	18.49	58	76695	16850	64405129
Cardiac operation	23.47	18.49	27	76726	4187	64417792
Application site reaction	23.30	18.49	13	76740	702	64421277
Abdominal pain upper	23.25	18.49	314	76439	174716	64247263
Injection site pruritus	23.20	18.49	8	76745	37818	64384161
Spinal cord ischaemia	23.14	18.49	8	76745	132	64421847
Acute respiratory failure	23.09	18.49	119	76634	49815	64372164
Cardiac disorder	23.08	18.49	129	76624	55687	64366292
Biopsy thyroid gland	22.94	18.49	4	76749	0	64421979
Aphasia	22.86	18.49	10	76743	40896	64381083
Thyroxine free increased	22.81	18.49	15	76738	1092	64420887
Female sterilisation	22.71	18.49	9	76744	221	64421758
Application site vesicles	22.69	18.49	16	76737	1306	64420673
Myelodysplastic syndrome	22.65	18.49	3	76750	27576	64394403
Suture insertion	22.50	18.49	8	76745	144	64421835
Speech disorder	22.46	18.49	15	76738	48426	64373553
Osteoporosis	22.41	18.49	11	76742	42069	64379910
Dizziness postural	22.36	18.49	41	76712	9711	64412268
Dizziness exertional	22.20	18.49	11	76742	465	64421514
Neuropathy peripheral	22.14	18.49	69	76684	117456	64304523
Catheter site scar	22.02	18.49	5	76748	14	64421965
Diuretic therapy	21.95	18.49	8	76745	155	64421824
Transaminases increased	21.79	18.49	13	76740	44581	64377398
Concomitant disease progression	21.77	18.49	23	76730	3246	64418733
Loss of personal independence in daily activities	21.55	18.49	33	76720	72421	64349558
Intra-abdominal fluid collection	21.53	18.49	21	76732	2696	64419283
Emotional distress	21.46	18.49	8	76745	36030	64385949
Dialysis	21.43	18.49	56	76697	16864	64405115
Device use error	21.29	18.49	32	76721	6439	64415540
Wound treatment	21.22	18.49	8	76745	171	64421808
Fibromyalgia	21.16	18.49	8	76745	35723	64386256
Acute hepatic failure	21.07	18.49	3	76750	26109	64395870
Exercise tolerance decreased	21.04	18.49	35	76718	7675	64414304
Ventricular assist device insertion	20.96	18.49	6	76747	51	64421928
Upper respiratory tract congestion	20.85	18.49	19	76734	2239	64419740
Pneumonia aspiration	20.67	18.49	24	76729	59247	64362732
Ear infection	20.56	18.49	68	76685	23336	64398643
Proteinuria	20.56	18.49	4	76749	27719	64394260
Vertigo	20.47	18.49	24	76729	58987	64362992
Jugular vein distension	20.40	18.49	15	76738	1307	64420672
Cardiomyopathy	20.25	18.49	3	76750	25353	64396626
Drug titration	20.17	18.49	4	76749	4	64421975
Culture negative	20.17	18.49	4	76749	4	64421975
Respiratory failure	20.12	18.49	286	76467	160897	64261082
Bacteraemia	20.02	18.49	74	76679	26837	64395142
Pulmonary alveolar haemorrhage	19.92	18.49	39	76714	9699	64412280
Pulmonary endarterectomy	19.83	18.49	8	76745	206	64421773
Pneumonitis	19.12	18.49	19	76734	50346	64371633
Injection site haemorrhage	19.10	18.49	3	76750	24275	64397704
Biopsy skin	19.03	18.49	6	76747	73	64421906
Irritability	18.98	18.49	10	76743	36736	64385243
Stent placement	18.97	18.49	28	76725	5543	64416436
Hypoaesthesia	18.95	18.49	93	76660	139015	64282964
Pancreatitis acute	18.91	18.49	14	76739	42841	64379138
Middle ear effusion	18.81	18.49	17	76736	1982	64419997
Localised oedema	18.77	18.49	32	76721	7159	64414820
Body temperature decreased	18.69	18.49	4	76749	25924	64396055
Chronic respiratory failure	18.54	18.49	19	76734	2587	64419392
Pulmonary artery dilatation	18.53	18.49	9	76744	364	64421615

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AC09	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Platelet aggregation inhibitors excl. heparin
FDA CS	M0017817	Prostaglandins I
FDA PE	N0000009909	Vasodilation
FDA EPC	N0000175416	Prostacycline Vasodilator
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D006401	Hematologic Agents
MeSH PA	D010975	Platelet Aggregation Inhibitors
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pulmonary arterial hypertension	indication	11399002
Cough	indication	49727002
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Rhinitis	indication	70076002	DOID:4483
Pulmonary hypertension	indication	70995007	DOID:6432
Common cold	indication	82272006	DOID:10459
Pulmonary edema	contraindication	19242006	DOID:11396
Chronic heart failure	contraindication	48447003
Blood coagulation disorder	contraindication	64779008	DOID:1247

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.75	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin E2 receptor EP1 subtype	GPCR	P34995	PE2R1_HUMAN	AGONIST	Ki	4.80		IUPHAR	IUPHAR
Prostacyclin receptor	GPCR	P43119	PI2R_HUMAN	AGONIST	Ki	7.80		IUPHAR	CHEMBL
P2Y purinoceptor 12	GPCR	Q9H244	P2Y12_HUMAN					WOMBAT-PK
Prostaglandin E2 receptor EP4 subtype	GPCR	P35408	PE2R4_HUMAN	AGONIST	Ki	5.10		IUPHAR

External reference:

ID	Source
4024020	VUID
N0000022025	NUI
D00106	KEGG_DRUG
61849-14-7	SECONDARY_CAS_RN
4020958	VANDF
4024020	VANDF
C0033567	UMLSCUI
CHEBI:15552	CHEBI
CHEMBL1139	ChEMBL_ID
DB01240	DRUGBANK_ID
CHEMBL962	ChEMBL_ID
D011464	MESH_DESCRIPTOR_UI
5282411	PUBCHEM_CID
4725	INN_ID
DCR9Z582X0	UNII
104463	RXNORM
137029	MMSL
29551	MMSL
4669	MMSL
d03842	MMSL
003963	NDDF
003964	NDDF
108593000	SNOMEDCT_US
108594006	SNOMEDCT_US
372513003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
FLOLAN	HUMAN PRESCRIPTION DRUG LABEL	1	0173-0517	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	0.50 mg	INTRAVENOUS	NDA	25 sections
FLOLAN	HUMAN PRESCRIPTION DRUG LABEL	1	0173-0519	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	1.50 mg	INTRAVENOUS	NDA	25 sections
Epoprostenol Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0703-1985	INJECTION, POWDER, FOR SOLUTION	0.50 mg	INTRAVENOUS	ANDA	23 sections
Epoprostenol Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0703-1995	INJECTION, POWDER, FOR SOLUTION	1.50 mg	INTRAVENOUS	ANDA	23 sections
epoprostenol	Human Prescription Drug Label	1	62756-059	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	0.50 mg	INTRAVENOUS	ANDA	25 sections
epoprostenol	Human Prescription Drug Label	1	62756-060	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	1.50 mg	INTRAVENOUS	ANDA	25 sections
Veletri	HUMAN PRESCRIPTION DRUG LABEL	1	66215-402	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	1.50 mg	INTRAVENOUS	NDA	28 sections
Veletri	HUMAN PRESCRIPTION DRUG LABEL	1	66215-403	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	0.50 mg	INTRAVENOUS	NDA	28 sections