epoprostenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prostaglandins 1034 35121-78-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • epoprostenol
  • epoprostenol sodium
  • prostacyclin
  • vasocyclin
  • Prostaglandin I2
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
  • Molecular weight: 352.47
  • Formula: C20H32O5
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 86.99
  • ALOGS: -3.41
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 20, 1995 FDA GLAXOSMITHKLINE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pain in jaw 3032.15 18.15 1315 65284 37113 50501412
Catheter site erythema 1912.80 18.15 527 66072 3435 50535090
Catheter management 1569.00 18.15 417 66182 2322 50536203
Catheter site pruritus 1426.39 18.15 362 66237 1625 50536900
Device related infection 1377.76 18.15 630 65969 20105 50518420
Flushing 1251.15 18.15 886 65713 66129 50472396
Right ventricular failure 1116.06 18.15 502 66097 15391 50523134
Catheter site discharge 1096.49 18.15 290 66309 1578 50536947
Catheter site pain 1082.64 18.15 335 66264 3427 50535098
Dyspnoea exertional 1010.83 18.15 701 65898 50532 50487993
Catheter site infection 978.65 18.15 320 66279 3966 50534559
Fluid retention 945.57 18.15 670 65929 49979 50488546
Dyspnoea 873.54 18.15 2093 64506 545515 49993010
Device leakage 842.55 18.15 310 66289 5568 50532957
Device alarm issue 779.03 18.15 208 66391 1180 50537345
Lung transplant 702.25 18.15 225 66374 2600 50535925
Drug ineffective 684.36 18.15 128 66471 819205 49719320
Catheter site haemorrhage 666.61 18.15 216 66383 2594 50535931
Hypervolaemia 665.90 18.15 416 66183 25083 50513442
Catheter placement 662.36 18.15 199 66400 1825 50536700
Central venous catheterisation 635.32 18.15 195 66404 1935 50536590
Catheter site rash 618.80 18.15 153 66446 602 50537923
Hospitalisation 603.24 18.15 584 66015 67353 50471172
Device occlusion 590.25 18.15 241 66358 5782 50532743
Catheter site swelling 535.81 18.15 154 66445 1190 50537335
Headache 526.78 18.15 1658 64941 504877 50033648
Pulmonary hypertension 486.45 18.15 381 66218 33036 50505489
Complication associated with device 443.88 18.15 263 66336 14392 50524133
Catheter site inflammation 414.33 18.15 109 66490 578 50537947
Diarrhoea 396.17 18.15 1673 64926 586803 49951722
Pulmonary arterial hypertension 365.37 18.15 263 66336 20056 50518469
Death 352.40 18.15 1082 65517 324297 50214228
Catheter site irritation 348.67 18.15 90 66509 437 50538088
Vascular device infection 334.88 18.15 147 66452 4237 50534288
Off label use 334.22 18.15 105 66494 474321 50064204
Device infusion issue 319.82 18.15 104 66495 1263 50537262
Therapy change 316.33 18.15 149 66450 5076 50533449
Transplant evaluation 311.68 18.15 96 66503 964 50537561
Device dislocation 299.15 18.15 239 66360 21307 50517218
Device breakage 298.70 18.15 175 66424 9372 50529153
Palpitations 297.64 18.15 483 66116 94023 50444502
Transfusion 283.60 18.15 189 66410 12716 50525809
Catheter site vesicles 246.27 18.15 61 66538 242 50538283
Oedema 236.42 18.15 370 66229 69811 50468714
Dermatitis contact 230.46 18.15 143 66456 8503 50530022
Toxicity to various agents 230.42 18.15 12 66587 212487 50326038
Paracentesis 227.80 18.15 73 66526 843 50537682
Ascites 219.33 18.15 253 66346 35608 50502917
Catheter site related reaction 216.85 18.15 68 66531 728 50537797
Emergency care 209.61 18.15 67 66532 767 50537758
Infusion related reaction 207.58 18.15 3 66596 169554 50368971
Pulmonary arterial pressure increased 201.20 18.15 95 66504 3253 50535272
Rheumatoid arthritis 200.52 18.15 18 66581 202532 50335993
Device connection issue 199.62 18.15 59 66540 508 50538017
Alopecia 193.44 18.15 43 66556 245004 50293521
Catheterisation cardiac 192.96 18.15 98 66501 3942 50534583
Hypoxia 192.62 18.15 284 66315 50839 50487686
Nausea 188.56 18.15 1574 65025 703824 49834701
Chest pain 185.95 18.15 583 66016 176299 50362226
Oxygen saturation decreased 180.37 18.15 336 66263 72912 50465613
Catheter removal 178.79 18.15 49 66550 311 50538214
Thrombosis in device 174.68 18.15 81 66518 2660 50535865
Drug interaction 172.44 18.15 28 66571 199593 50338932
Drug hypersensitivity 172.00 18.15 58 66541 250952 50287573
Device physical property issue 168.72 18.15 68 66531 1574 50536951
Joint swelling 165.77 18.15 58 66541 245228 50293297
Medical device change 165.10 18.15 45 66554 279 50538246
Device malfunction 164.98 18.15 146 66453 14975 50523550
Therapeutic product effect decreased 164.02 18.15 3 66596 136047 50402478
Arthropathy 161.88 18.15 12 66587 157894 50380631
Treatment failure 158.42 18.15 5 66594 137632 50400893
Neutropenia 158.32 18.15 9 66590 147956 50390569
Oxygen consumption increased 135.41 18.15 74 66525 3462 50535063
Central venous catheter removal 133.50 18.15 39 66560 321 50538204
Drug intolerance 126.89 18.15 65 66534 219039 50319486
Cardiac failure 126.45 18.15 297 66302 75743 50462782
Haemoptysis 124.78 18.15 161 66438 25412 50513113
Blood culture positive 124.38 18.15 75 66524 4233 50534292
Glossodynia 123.70 18.15 7 66592 115562 50422963
Catheter site scab 123.35 18.15 32 66567 159 50538366
Application site pruritus 123.12 18.15 71 66528 3688 50534837
Dyspnoea at rest 122.43 18.15 70 66529 3577 50534948
Hypertension 120.31 18.15 64 66535 211139 50327386
Musculoskeletal stiffness 117.93 18.15 15 66584 128466 50410059
Product use issue 116.31 18.15 27 66572 149448 50389077
Maternal exposure during pregnancy 112.75 18.15 35 66564 159743 50378782
Febrile neutropenia 110.77 18.15 4 66595 97663 50440862
Hepatic enzyme increased 110.56 18.15 23 66576 137357 50401168
Hypotension 110.30 18.15 605 65994 234864 50303661
Stomatitis 105.86 18.15 7 66592 101337 50437188
Skin irritation 105.69 18.15 85 66514 7642 50530883
Catheter site warmth 105.29 18.15 29 66570 188 50538337
Device related sepsis 104.23 18.15 62 66537 3413 50535112
Blood culture negative 102.88 18.15 26 66573 114 50538411
Device issue 100.99 18.15 128 66471 19844 50518681
Unevaluable event 100.69 18.15 201 66398 45865 50492660
Abdominal distension 98.36 18.15 263 66336 72640 50465885
Discomfort 96.26 18.15 14 66585 108366 50430159
Product use in unapproved indication 96.11 18.15 18 66581 115801 50422724
Oedema peripheral 94.46 18.15 435 66164 157526 50380999
Injection site pain 90.55 18.15 18 66581 111006 50427519
Nasal congestion 89.72 18.15 204 66395 50916 50487609
Heart and lung transplant 87.89 18.15 22 66577 92 50538433
Catheter site discolouration 87.32 18.15 22 66577 95 50538430
Weight decreased 87.05 18.15 543 66056 220702 50317823
Blood pressure increased 85.61 18.15 34 66565 133098 50405427
Catheter site cellulitis 85.34 18.15 25 66574 208 50538317
Staphylococcus test positive 84.90 18.15 54 66545 3352 50535173
Abdominal cavity drainage 84.64 18.15 28 66571 360 50538165
Scleroderma 83.65 18.15 61 66538 4740 50533785
Therapeutic product effect incomplete 83.20 18.15 11 66588 91504 50447021
Application site irritation 82.48 18.15 41 66558 1574 50536951
Gastritis hypertrophic 82.37 18.15 18 66581 34 50538491
Product administration interrupted 80.19 18.15 35 66564 994 50537531
Catheter culture positive 80.03 18.15 21 66578 110 50538415
Malaise 79.68 18.15 731 65868 334801 50203724
Intentional product use issue 75.60 18.15 7 66592 76911 50461614
Pulmonary veno-occlusive disease 75.45 18.15 33 66566 942 50537583
White blood cell count decreased 74.73 18.15 30 66569 116692 50421833
Transplant 74.04 18.15 29 66570 621 50537904
Hyperthyroidism 72.89 18.15 85 66514 12090 50526435
Pericarditis 72.64 18.15 9 66590 78680 50459845
Psoriasis 71.37 18.15 5 66594 68995 50469530
Disease progression 67.97 18.15 278 66321 95588 50442937
Confusional state 66.88 18.15 88 66511 185840 50352685
Wound 66.41 18.15 28 66571 105766 50432759
Depression 66.20 18.15 72 66527 165351 50373174
Drug abuse 66 18.15 3 66596 59843 50478682
Syncope 65.52 18.15 289 66310 102713 50435812
Osteoarthritis 65.44 18.15 7 66592 68599 50469926
Pneumonia 65.00 18.15 772 65827 377629 50160896
Inappropriate schedule of product administration 64.42 18.15 9 66590 71822 50466703
Leukopenia 64.13 18.15 7 66592 67521 50471004
Pericardial effusion 63.69 18.15 118 66481 25471 50513054
Investigation 63.66 18.15 34 66565 1518 50537007
Emergency care examination 63.29 18.15 15 66584 47 50538478
Aspiration pleural cavity 62.82 18.15 27 66572 738 50537787
Condition aggravated 61.98 18.15 630 65969 296428 50242097
Walking distance test abnormal 61.27 18.15 24 66575 514 50538011
Heart rate increased 61.21 18.15 232 66367 77018 50461507
Acute kidney injury 60.75 18.15 131 66468 227927 50310598
Cardiac ablation 60.66 18.15 31 66568 1263 50537262
Vomiting 60.45 18.15 895 65704 459863 50078662
Hypersensitivity 60.34 18.15 120 66479 215041 50323484
Impaired healing 59.72 18.15 10 66589 69776 50468749
Pulmonary oedema 59.49 18.15 170 66429 48768 50489757
Pain in extremity 59.48 18.15 584 66015 272281 50266244
Arthralgia 59.36 18.15 337 66262 438365 50100160
Oxygen therapy 58.74 18.15 34 66565 1778 50536747
Liver transplant 58.68 18.15 36 66563 2096 50536429
Application site erythema 58.02 18.15 48 66551 4490 50534035
Mobility decreased 57.29 18.15 17 66582 79931 50458594
Systemic lupus erythematosus 56.48 18.15 61 66538 140561 50397964
Somnolence 56.09 18.15 73 66526 154912 50383613
Infusion site infection 55.31 18.15 31 66568 1524 50537001
Pain 53.96 18.15 495 66104 578408 49960117
Coma 53.75 18.15 6 66593 56873 50481652
Injection site reaction 53.61 18.15 3 66596 50029 50488496
Injection site erythema 53.57 18.15 16 66583 74920 50463605
Presyncope 53.36 18.15 106 66493 24092 50514433
Clostridium difficile infection 53.19 18.15 109 66490 25330 50513195
Catheter site nodule 53.01 18.15 13 66586 49 50538476
Wrong technique in product usage process 52.09 18.15 6 66593 55504 50483021
Infusion site erythema 49.05 18.15 59 66540 8668 50529857
Gait disturbance 48.98 18.15 76 66523 149929 50388596
Acute right ventricular failure 48.66 18.15 15 66584 151 50538374
Duodenal ulcer perforation 48.06 18.15 3 66596 45608 50492917
Anaphylactic reaction 47.94 18.15 7 66592 54048 50484477
Electrocardiogram QT prolonged 47.72 18.15 6 66593 51880 50486645
Catheter site dermatitis 47.60 18.15 12 66587 52 50538473
Overdose 47.47 18.15 37 66562 99690 50438835
Suicidal ideation 47.25 18.15 8 66591 55377 50483148
Intentional product misuse 46.60 18.15 4 66595 46730 50491795
Platelet transfusion 46.22 18.15 21 66578 657 50537868
Decreased appetite 46.18 18.15 435 66164 200488 50338037
Blood potassium decreased 45.54 18.15 129 66470 36816 50501709
Application site hypersensitivity 45.33 18.15 15 66584 193 50538332
Suicide attempt 45.19 18.15 7 66592 51725 50486800
Catheter site extravasation 44.93 18.15 16 66583 260 50538265
Staphylococcal infection 44.53 18.15 125 66474 35491 50503034
Ventilation perfusion mismatch 43.98 18.15 15 66584 213 50538312
Catheter site induration 43.20 18.15 11 66588 50 50538475
Immunoglobulin G4 related disease 43.03 18.15 11 66588 51 50538474
Right ventricular dilatation 42.21 18.15 22 66577 934 50537591
Catheter site erosion 41.86 18.15 11 66588 58 50538467
Pulmonary haemorrhage 41.69 18.15 47 66552 6445 50532080
Hallucination 41.47 18.15 6 66593 46651 50491874
Disease complication 41.04 18.15 32 66567 2750 50535775
Dizziness 40.79 18.15 661 65938 345708 50192817
Catheter site hypersensitivity 40.73 18.15 12 66587 102 50538423
Pulmonary arterial pressure abnormal 40.34 18.15 17 66582 442 50538083
Seizure 40.14 18.15 58 66541 117816 50420709
Blood glucose increased 39.99 18.15 22 66577 71302 50467223
Pruritus 39.82 18.15 215 66384 283353 50255172
Injury 39.73 18.15 8 66591 48917 50489608
Epistaxis 39.55 18.15 178 66421 63776 50474749
Hypoglycaemia 39.11 18.15 11 66588 53570 50484955
Pancytopenia 38.95 18.15 32 66567 83998 50454527
Catheter site bruise 38.75 18.15 15 66584 311 50538214
Lower respiratory tract infection 38.54 18.15 41 66558 95160 50443365
Concomitant disease aggravated 37.99 18.15 50 66549 8041 50530484
Pulmonary embolism 37.72 18.15 47 66552 101657 50436868
Cardiac failure high output 37.64 18.15 14 66585 259 50538266
Cough 37.34 18.15 483 66116 240781 50297744
Depressed level of consciousness 37.30 18.15 11 66588 51942 50486583
Nasopharyngitis 37.25 18.15 403 66196 192524 50346001
Respiratory failure 37.15 18.15 226 66373 90955 50447570
Application site rash 36.71 18.15 28 66571 2329 50536196
Endotracheal intubation 36.69 18.15 27 66572 2127 50536398
Balance disorder 36.45 18.15 24 66575 70566 50467959
Myocardial infarction 36.42 18.15 38 66561 88989 50449536
Deep vein thrombosis 36.42 18.15 26 66573 73278 50465247
Therapeutic embolisation 36.22 18.15 12 66587 155 50538370
Hyponatraemia 36.10 18.15 44 66555 96095 50442430
Thyroidectomy 36.04 18.15 20 66579 964 50537561
Suture related complication 35.74 18.15 12 66587 162 50538363
Dysphagia 35.34 18.15 30 66569 77488 50461037
Catheter site oedema 35.15 18.15 9 66590 42 50538483
Lung assist device therapy 34.81 18.15 10 66589 77 50538448
Cognitive disorder 34.23 18.15 8 66591 44115 50494410
Catheter site urticaria 33.77 18.15 8 66591 25 50538500
Ear discomfort 33.73 18.15 43 66556 6701 50531824
First bite syndrome 33.67 18.15 7 66592 9 50538516
Abortion spontaneous 33.57 18.15 7 66592 41765 50496760
Catheter site dryness 33.08 18.15 8 66591 28 50538497
Cerebrovascular accident 32.81 18.15 46 66553 94634 50443891
C-reactive protein increased 32.47 18.15 24 66575 66450 50472075
Chest discomfort 32.36 18.15 221 66378 92501 50446024
Irritable bowel syndrome 31.66 18.15 14 66585 51427 50487098
Urticaria 31.57 18.15 78 66521 129483 50409042
Bacteraemia 31.55 18.15 63 66536 14370 50524155
Osteoporosis 31.32 18.15 10 66589 44869 50493656
Pulmonary alveolar haemorrhage 30.84 18.15 32 66567 3995 50534530
Mineral supplementation 30.62 18.15 16 66583 683 50537842
Atrial flutter 30.58 18.15 47 66552 8716 50529809
Blood pressure systolic increased 30.50 18.15 5 66594 35444 50503081
Dizziness postural 30.45 18.15 39 66560 6106 50532419
Biopsy liver 29.76 18.15 13 66586 370 50538155
Fibromyalgia 29.70 18.15 11 66588 44967 50493558
Infusion site pruritus 29.64 18.15 31 66568 3906 50534619
Catheter site thrombosis 29.51 18.15 10 66589 139 50538386
Hyperglycaemia 29.46 18.15 6 66593 36399 50502126
Bradycardia 29.28 18.15 25 66574 64401 50474124
Female sterilisation 29.05 18.15 14 66585 502 50538023
Congestive hepatopathy 29.05 18.15 25 66574 2469 50536056
Catheterisation cardiac abnormal 29.01 18.15 11 66588 215 50538310
Systemic-pulmonary artery shunt 28.84 18.15 7 66592 25 50538500
Paraesthesia 28.82 18.15 73 66526 120170 50418355
Device related thrombosis 28.36 18.15 19 66580 1288 50537237
Injection site pruritus 28.21 18.15 9 66590 40402 50498123
Caesarean section 28.08 18.15 63 66536 15576 50522949
Product deposit 27.94 18.15 10 66589 165 50538360
Hypoaesthesia 27.70 18.15 81 66518 127176 50411349
Sleep disorder 27.57 18.15 21 66578 57262 50481263
Right ventricular dysfunction 27.49 18.15 20 66579 1548 50536977
Loss of personal independence in daily activities 27.43 18.15 31 66568 70019 50468506
Urinary tract infection 27.11 18.15 178 66421 223842 50314683
Application site odour 26.95 18.15 7 66592 35 50538490
Concomitant disease progression 26.92 18.15 22 66577 2023 50536502
Knee arthroplasty 26.83 18.15 7 66592 35839 50502686
Tri-iodothyronine increased 26.77 18.15 9 66590 122 50538403
No adverse event 26.22 18.15 6 66593 33572 50504953
Balloon atrial septostomy 26.18 18.15 8 66591 78 50538447
Coronary artery disease 26.01 18.15 4 66595 29722 50508803
Echocardiogram abnormal 25.70 18.15 17 66582 1128 50537397
Culture positive 25.46 18.15 12 66587 409 50538116
Biopsy bone marrow 25.41 18.15 11 66588 306 50538219
Jugular vein distension 25.29 18.15 15 66584 821 50537704
Mechanical ventilation 25.16 18.15 17 66582 1169 50537356
Agitation 25.15 18.15 20 66579 53364 50485161
Tracheostomy 25.05 18.15 13 66586 547 50537978
Blood pressure fluctuation 24.97 18.15 8 66591 35815 50502710
Multiple allergies 24.89 18.15 42 66557 8421 50530104
Catheter site abscess 24.81 18.15 6 66593 21 50538504
Emotional distress 24.76 18.15 4 66595 28659 50509866
Swollen tongue 24.72 18.15 4 66595 28626 50509899
General physical health deterioration 24.67 18.15 100 66499 142334 50396191
Hospice care 24.56 18.15 34 66565 5738 50532787
Cholecystectomy 24.54 18.15 44 66555 9259 50529266
Tremor 24.38 18.15 74 66525 114829 50423696
Terminal state 24.27 18.15 21 66578 2089 50536436
Urinary retention 24.15 18.15 3 66596 26187 50512338
Asthma 24.01 18.15 51 66548 89286 50449239
Biopsy lymph gland 23.61 18.15 6 66593 27 50538498
Orthostatic hypotension 23.56 18.15 5 66594 29476 50509049
Disturbance in attention 23.52 18.15 6 66593 31180 50507345
Therapeutic procedure 23.49 18.15 14 66585 773 50537752
Femur fracture 23.36 18.15 10 66589 37454 50501071
Cardioversion 23.31 18.15 16 66583 1129 50537396
Contusion 23.27 18.15 73 66526 112110 50426415
Infusion site rash 23.26 18.15 17 66582 1325 50537200
Dry mouth 22.95 18.15 24 66575 56154 50482371
Arthritis 22.90 18.15 50 66549 86671 50451854
Application site reaction 22.79 18.15 13 66586 661 50537864
Oral pain 22.76 18.15 3 66596 25030 50513495
Upper respiratory tract congestion 22.66 18.15 19 66580 1810 50536715
Lactic acidosis 22.29 18.15 8 66591 33347 50505178
Stent placement 22.26 18.15 25 66574 3413 50535112
Hypokalaemia 22.20 18.15 52 66547 87940 50450585
Cardiac output increased 22.08 18.15 8 66591 137 50538388
Drug-induced liver injury 21.98 18.15 5 66594 28090 50510435
Blister 21.94 18.15 50 66549 85368 50453157
Myalgia 21.84 18.15 255 66344 124064 50414461
Metabolic acidosis 21.72 18.15 12 66587 38813 50499712
Vertigo 21.33 18.15 22 66577 51810 50486715
Brain natriuretic peptide increased 21.29 18.15 28 66571 4499 50534026
Dysentery 21.17 18.15 13 66586 758 50537767
Delirium 21.09 18.15 12 66587 38180 50500345
Dry eye 20.94 18.15 8 66591 32087 50506438
Cardiac flutter 20.85 18.15 24 66575 3366 50535159
Endarterectomy 20.84 18.15 8 66591 162 50538363
Acute respiratory failure 20.80 18.15 84 66515 28698 50509827
Pulmonary artery dilatation 20.77 18.15 9 66590 251 50538274
Therapeutic response decreased 20.65 18.15 19 66580 47212 50491313
Insomnia 20.61 18.15 140 66459 174725 50363800
Angioedema 20.57 18.15 12 66587 37664 50500861
Aphasia 20.51 18.15 6 66593 28488 50510037
Adrenocorticotropic hormone deficiency 20.51 18.15 9 66590 259 50538266
Suture insertion 20.42 18.15 7 66592 101 50538424
Catheter site mass 20.35 18.15 5 66594 19 50538506
Culture negative 20.30 18.15 4 66595 3 50538522
Catheter site scar 20.30 18.15 4 66595 3 50538522
Muscular weakness 20.29 18.15 61 66538 94952 50443573
Supraventricular tachycardia 20.17 18.15 49 66550 12752 50525773
Speech disorder 19.87 18.15 11 66588 35537 50502988
Dyskinesia 19.81 18.15 6 66593 27855 50510670
N-terminal prohormone brain natriuretic peptide increased 19.63 18.15 17 66582 1693 50536832
Drain placement 19.59 18.15 6 66593 59 50538466
Hepatocellular injury 19.55 18.15 5 66594 25942 50512583
Pituitary enlargement 19.42 18.15 5 66594 24 50538501
Chronic right ventricular failure 19.42 18.15 5 66594 24 50538501
Inflammation 19.37 18.15 28 66571 56884 50481641
Cardiac output decreased 19.33 18.15 13 66586 887 50537638
Pulmonary capillary haemangiomatosis 19.25 18.15 5 66594 25 50538500
Infusion site pain 19.18 18.15 47 66552 12299 50526226
Visual impairment 19.17 18.15 38 66561 68237 50470288
Cardiac disorder 19.09 18.15 109 66490 42870 50495655
Cholestasis 18.94 18.15 5 66594 25396 50513129
Diabetes mellitus 18.87 18.15 22 66577 49011 50489514
Biopsy skin 18.82 18.15 6 66593 68 50538457
Irritability 18.69 18.15 7 66592 28419 50510106
Plasma cell myeloma 18.53 18.15 9 66590 31313 50507212
Right atrial dilatation 18.51 18.15 11 66588 604 50537921
Silent thyroiditis 18.51 18.15 6 66593 72 50538453
Cor pulmonale 18.19 18.15 17 66582 1870 50536655

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pain in jaw 1063.13 24.88 354 16548 11287 29546338
Catheter management 604.15 24.88 131 16771 713 29556912
Catheter site erythema 468.96 24.88 114 16788 1097 29556528
Right ventricular failure 459.66 24.88 172 16730 7718 29549907
Fluid retention 400.92 24.88 217 16685 23343 29534282
Device related infection 361.31 24.88 177 16725 15459 29542166
Catheter site pruritus 342.67 24.88 69 16833 242 29557383
Device alarm issue 299.58 24.88 69 16833 513 29557112
Lung transplant 293.54 24.88 85 16817 1671 29555954
Catheter placement 287.90 24.88 69 16833 621 29557004
Headache 264.55 24.88 404 16498 173603 29384022
Dyspnoea 262.98 24.88 575 16327 326157 29231468
Device occlusion 257.91 24.88 103 16799 5505 29552120
Flushing 252.47 24.88 174 16728 28818 29528807
Catheter site discharge 223.14 24.88 54 16848 508 29557117
Catheter site infection 222.34 24.88 71 16831 1961 29555664
Hypervolaemia 213.55 24.88 130 16772 17415 29540210
Dyspnoea exertional 206.11 24.88 169 16733 36321 29521304
Catheter site pain 197.45 24.88 57 16845 1107 29556518
Pulmonary hypertension 179.37 24.88 119 16783 18489 29539136
Device dislocation 176.90 24.88 74 16828 4453 29553172
Complication associated with device 176.87 24.88 77 16825 5114 29552511
Catheter site haemorrhage 165.75 24.88 57 16845 1991 29555634
Central venous catheterisation 159.25 24.88 47 16855 989 29556636
Catheter site rash 149.76 24.88 32 16870 160 29557465
Device leakage 144.47 24.88 64 16838 4431 29553194
Pulmonary arterial hypertension 124.80 24.88 68 16834 7381 29550244
Oxygen saturation decreased 123.49 24.88 140 16762 44797 29512828
Hospitalisation 115.85 24.88 137 16765 45851 29511774
Catheter removal 110.84 24.88 25 16877 167 29557458
Catheter site inflammation 108.14 24.88 25 16877 189 29557436
Catheter site irritation 104.86 24.88 22 16880 99 29557526
Medical device change 102.90 24.88 21 16881 80 29557545
Transplant evaluation 101.53 24.88 28 16874 457 29557168
Drug interaction 95.80 24.88 4 16898 197381 29360244
Catheter site swelling 94.55 24.88 24 16878 279 29557346
Paracentesis 92.24 24.88 25 16877 381 29557244
Pulmonary veno-occlusive disease 89.70 24.88 25 16877 425 29557200
Device infusion issue 86.39 24.88 26 16876 586 29557039
Thrombosis in device 85.71 24.88 40 16862 3124 29554501
Toxicity to various agents 79.57 24.88 5 16897 173656 29383969
Therapy change 77.12 24.88 35 16867 2563 29555062
Pain in extremity 76.43 24.88 184 16718 110249 29447376
Condition aggravated 76.04 24.88 219 16683 146076 29411549
Oedema 75.64 24.88 104 16798 40379 29517246
Ascites 74.41 24.88 98 16804 36521 29521104
Device connection issue 73.66 24.88 20 16882 307 29557318
Transfusion 73.50 24.88 48 16854 7250 29550375
Device breakage 73.32 24.88 30 16872 1704 29555921
Vascular device infection 72.01 24.88 33 16869 2472 29555153
Heart and lung transplant 71.77 24.88 15 16887 66 29557559
Blood culture positive 63.68 24.88 37 16865 4540 29553085
Neutropenia 62.76 24.88 3 16899 131708 29425917
Hypoxia 61.86 24.88 103 16799 47276 29510349
Death 61.16 24.88 368 16534 341716 29215909
Concomitant disease aggravated 60.80 24.88 37 16865 4941 29552684
Device physical property issue 60.25 24.88 20 16882 625 29557000
Diarrhoea 58.88 24.88 357 16545 332341 29225284
Oxygen consumption increased 56.93 24.88 23 16879 1264 29556361
Abdominal distension 56.21 24.88 97 16805 45814 29511811
Catheterisation cardiac 54.57 24.88 26 16876 2127 29555498
Pulmonary arterial pressure increased 53.59 24.88 21 16881 1065 29556560
Device malfunction 53.47 24.88 42 16860 8465 29549160
Drug ineffective 52.74 24.88 79 16823 363091 29194534
Product deposit 52.50 24.88 15 16887 280 29557345
Febrile neutropenia 52.07 24.88 3 16899 112237 29445388
Haemoptysis 51.88 24.88 75 16827 30475 29527150
Off label use 50.19 24.88 59 16843 300741 29256884
Liver transplant 49.80 24.88 25 16877 2291 29555334
Device related sepsis 48.04 24.88 25 16877 2470 29555155
Catheter site vesicles 46.27 24.88 9 16893 25 29557600
Blood culture negative 40.67 24.88 8 16894 24 29557601
Device issue 37.62 24.88 33 16869 7747 29549878
Nausea 37.08 24.88 287 16615 288968 29268657
Cardiac failure 36.63 24.88 114 16788 79173 29478452
Dermatitis contact 35.92 24.88 22 16880 2970 29554655
Oxygen therapy 35.83 24.88 14 16888 704 29556921
Catheter site scab 33.73 24.88 6 16896 8 29557617
Palpitations 33.67 24.88 64 16838 32540 29525085
Abdominal cavity drainage 33.44 24.88 11 16891 334 29557291
Pulmonary endarterectomy 33.27 24.88 8 16894 73 29557552
Spinal cord ischaemia 33.07 24.88 8 16894 75 29557550
Micrococcus test positive 32.57 24.88 6 16896 11 29557614
Pulmonary oedema 32.53 24.88 74 16828 42661 29514964
White blood cell count decreased 31.42 24.88 5 16897 83357 29474268
Catheter culture positive 30.50 24.88 6 16896 18 29557607
Catheter site dermatitis 29.99 24.88 5 16897 3 29557622
Catheter site dryness 29.99 24.88 5 16897 3 29557622
Catheter site mass 29.80 24.88 6 16896 21 29557604
Oedema peripheral 29.29 24.88 127 16775 103430 29454195
Catheter site related reaction 28.12 24.88 9 16893 250 29557375
Central venous catheter removal 27.75 24.88 6 16896 32 29557593
Disease progression 27.55 24.88 106 16796 81810 29475815
Catheter site extravasation 27.29 24.88 7 16895 85 29557540
Epistaxis 26.36 24.88 77 16825 51627 29505998
Nasal congestion 25.90 24.88 42 16860 18837 29538788
Overdose 25.54 24.88 7 16895 79812 29477813
Catheter site warmth 25.23 24.88 6 16896 52 29557573
Myocardial infarction 25.16 24.88 16 16886 110280 29447345
Staphylococcus test positive 25.15 24.88 17 16885 2716 29554909
Balloon atrial septostomy 24.94 24.88 5 16897 17 29557608

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pain in jaw 3603.22 18.49 1469 75284 39286 64382693
Catheter site erythema 2106.52 18.49 581 76172 4268 64417711
Catheter management 1848.38 18.49 485 76268 2870 64419109
Catheter site pruritus 1579.36 18.49 391 76362 1757 64420222
Device related infection 1527.71 18.49 740 76013 29886 64392093
Right ventricular failure 1388.28 18.49 621 76132 20850 64401129
Flushing 1350.05 18.49 950 75803 77698 64344281
Fluid retention 1224.91 18.49 805 75948 58801 64363178
Catheter site discharge 1200.95 18.49 317 76436 1924 64420055
Catheter site pain 1143.02 18.49 355 76398 4107 64417872
Catheter site infection 1069.89 18.49 358 76395 5335 64416644
Dyspnoea exertional 991.07 18.49 769 75984 72961 64349018
Dyspnoea 987.83 18.49 2438 74315 716236 63705743
Device alarm issue 963.48 18.49 257 76496 1633 64420346
Device leakage 932.24 18.49 356 76397 7910 64414069
Catheter placement 883.04 18.49 257 76496 2336 64419643
Lung transplant 862.85 18.49 281 76472 3827 64418152
Headache 788.04 18.49 1855 74898 527612 63894367
Hypervolaemia 776.10 18.49 513 76240 37772 64384207
Device occlusion 728.81 18.49 314 76439 9599 64412380
Central venous catheterisation 722.73 18.49 223 76530 2518 64419461
Catheter site haemorrhage 719.37 18.49 252 76501 4339 64417640
Catheter site rash 666.62 18.49 167 76586 794 64421185
Complication associated with device 597.48 18.49 312 76441 14768 64407211
Pulmonary hypertension 572.75 18.49 447 76306 42692 64379287
Catheter site swelling 565.84 18.49 164 76589 1466 64420513
Hospitalisation 552.33 18.49 557 76196 74650 64347329
Drug ineffective 503.72 18.49 187 76566 840060 63581919
Catheter site inflammation 484.01 18.49 129 76624 816 64421163
Device dislocation 439.24 18.49 288 76465 20890 64401089
Diarrhoea 420.42 18.49 1833 74920 720871 63701108
Pulmonary arterial hypertension 410.41 18.49 296 76457 25071 64396908
Device breakage 389.81 18.49 196 76557 8559 64413420
Death 375.93 18.49 1343 75410 481362 63940617
Device infusion issue 372.16 18.49 121 76632 1637 64420342
Catheter site irritation 367.33 18.49 93 76660 465 64421514
Toxicity to various agents 364.96 18.49 16 76737 363497 64058482
Off label use 360.17 18.49 152 76601 632654 63789325
Transplant evaluation 332.99 18.49 108 76645 1449 64420530
Drug interaction 330.15 18.49 27 76726 362056 64059923
Transfusion 309.54 18.49 218 76535 17776 64404203
Palpitations 308.57 18.49 491 76262 103997 64317982
Oedema 288.09 18.49 444 76309 91491 64330488
Paracentesis 284.25 18.49 91 76662 1168 64420811
Vascular device infection 274.08 18.49 138 76615 6042 64415937
Therapy change 271.72 18.49 139 76614 6295 64415684
Nausea 267.39 18.49 1720 75033 784080 63637899
Dermatitis contact 262.05 18.49 152 76601 8848 64413131
Catheter removal 246.50 18.49 68 76685 498 64421481
Neutropenia 242.14 18.49 10 76743 239614 64182365
Oxygen saturation decreased 240.55 18.49 446 76307 106730 64315249
Catheter site vesicles 238.03 18.49 59 76694 266 64421713
Medical device change 237.82 18.49 64 76689 422 64421557
Thrombosis in device 235.98 18.49 117 76636 4954 64417025
Ascites 225.16 18.49 321 76432 61680 64360299
Catheterisation cardiac 222.53 18.49 111 76642 4762 64417217
Catheter site related reaction 221.29 18.49 71 76682 918 64421061
Device connection issue 221.13 18.49 69 76684 810 64421169
Device physical property issue 209.03 18.49 83 76670 2050 64419929
Device malfunction 208.88 18.49 171 76582 17462 64404517
Pulmonary arterial pressure increased 206.59 18.49 100 76653 4016 64417963
Emergency care 205.17 18.49 66 76687 861 64421118
Febrile neutropenia 192.38 18.49 7 76746 187650 64234329
Hypoxia 184.32 18.49 356 76397 87793 64334186
Infusion related reaction 176.39 18.49 4 76749 164463 64257516
Blood culture positive 165.53 18.49 108 76645 7760 64414219
Chest pain 159.05 18.49 628 76125 235352 64186627
Oxygen consumption increased 153.97 18.49 85 76668 4496 64417483
Central venous catheter removal 145.72 18.49 42 76711 367 64421612
Device related sepsis 144.62 18.49 85 76668 5070 64416909
Acute kidney injury 139.68 18.49 199 76554 449041 63972938
Catheter site scab 138.56 18.49 35 76718 173 64421806
Device issue 137.99 18.49 152 76601 22496 64399483
Rheumatoid arthritis 137.20 18.49 17 76736 164277 64257702
Heart and lung transplant 135.80 18.49 34 76719 161 64421818
Drug abuse 135.43 18.49 5 76748 132369 64289610
Application site pruritus 133.81 18.49 71 76682 3468 64418511
Abdominal distension 131.44 18.49 327 76426 95667 64326312
Blood culture negative 130.66 18.49 33 76720 163 64421816
Haemoptysis 127.80 18.49 218 76535 48830 64373149
Pulmonary veno-occlusive disease 127.61 18.49 52 76701 1376 64420603
Hypertension 126.39 18.49 76 76677 259185 64162794
Product use in unapproved indication 123.95 18.49 29 76724 176589 64245390
Therapeutic product effect decreased 122.91 18.49 3 76750 115348 64306631
Drug hypersensitivity 121.22 18.49 66 76687 237749 64184230
Unevaluable event 116.81 18.49 213 76540 50276 64371703
Catheter site warmth 115.68 18.49 32 76721 237 64421742
Oedema peripheral 113.22 18.49 523 76230 209794 64212185
Skin irritation 110.64 18.49 90 76663 9104 64412875
Treatment failure 108.28 18.49 8 76745 116808 64305171
Stomatitis 106.06 18.49 6 76747 109599 64312380
Pain in extremity 105.00 18.49 668 76085 302417 64119562
Condition aggravated 104.87 18.49 780 75973 371646 64050333
Arthropathy 104.78 18.49 11 76742 120956 64301023
Malaise 102.73 18.49 814 75939 395433 64026546
Dyspnoea at rest 102.65 18.49 74 76679 6255 64415724
Abdominal cavity drainage 102.64 18.49 37 76716 694 64421285
Nasal congestion 102.24 18.49 222 76531 59436 64362543
Catheter culture positive 100.59 18.49 27 76726 176 64421803
Cardiac failure 98.68 18.49 364 76389 132009 64289970
Application site irritation 96.72 18.49 44 76709 1532 64420447
Staphylococcus test positive 96.15 18.49 68 76685 5577 64416402
White blood cell count decreased 95.87 18.49 34 76719 157803 64264176
Joint swelling 94.39 18.49 71 76682 215311 64206668
Scleroderma 93.76 18.49 63 76690 4755 64417224
Alopecia 93.52 18.49 40 76713 165650 64256329
Confusional state 93.20 18.49 104 76649 261040 64160939
Hepatic enzyme increased 91.82 18.49 21 76732 129922 64292057
Product use issue 89.91 18.49 34 76719 151681 64270298
Musculoskeletal stiffness 88.90 18.49 19 76734 123187 64298792
Leukopenia 88.21 18.49 9 76744 101233 64320746
Overdose 84.66 18.49 42 76711 159524 64262455
Gastritis hypertrophic 84.18 18.49 18 76735 34 64421945
Weight decreased 83.51 18.49 604 76149 285135 64136844
Catheter site discolouration 82.61 18.49 21 76732 107 64421872
Catheter site cellulitis 81.03 18.49 27 76726 396 64421583
Liver transplant 80.81 18.49 54 76699 4038 64417941
Injection site pain 80.75 18.49 17 76736 111391 64310588
Blood pressure increased 80.71 18.49 53 76700 172499 64249480
Myocardial infarction 78.83 18.49 50 76703 165771 64256208
Pancytopenia 78.66 18.49 36 76717 143273 64278706
Coma 78.42 18.49 7 76746 87608 64334371
Infusion site infection 78.13 18.49 38 76715 1542 64420437
Intentional product use issue 76.88 18.49 11 76742 95353 64326626
Inappropriate schedule of product administration 75.92 18.49 10 76743 92276 64329703
Transplant 75.15 18.49 31 76722 847 64421132
Somnolence 74.96 18.49 79 76674 203566 64218413
Therapeutic product effect incomplete 74.57 18.49 16 76737 103466 64318513
Heart rate increased 74.07 18.49 272 76481 98403 64323576
Product administration interrupted 73.74 18.49 33 76720 1105 64420874
Investigation 73.53 18.49 41 76712 2211 64419768
Oxygen therapy 72.84 18.49 41 76712 2252 64419727
Pulmonary oedema 72.28 18.49 232 76521 78442 64343537
Disease progression 72.27 18.49 347 76406 141333 64280646
Electrocardiogram QT prolonged 72.05 18.49 6 76747 79442 64342537
Hyperthyroidism 71.73 18.49 98 76655 18081 64403898
Product deposit 70.63 18.49 24 76729 375 64421604
Infusion site erythema 69.77 18.49 61 76692 6812 64415167
Concomitant disease aggravated 69.50 18.49 77 76676 11465 64410514
Catheter site dermatitis 69.25 18.49 17 76736 73 64421906
Cardiac ablation 68.27 18.49 36 76717 1736 64420243
Hypotension 67.81 18.49 722 76031 380252 64041727
Vomiting 67.33 18.49 973 75780 550144 63871835
Drug intolerance 66.89 18.49 75 76678 187917 64234062
Psoriasis 66.18 18.49 5 76748 71698 64350281
Pericardial effusion 66.02 18.49 145 76608 39109 64382870
Catheter site extravasation 64.26 18.49 22 76731 352 64421627
Hyponatraemia 63.56 18.49 50 76703 148289 64273690
Aspiration pleural cavity 63.49 18.49 32 76721 1403 64420576
Hypoglycaemia 62.56 18.49 15 76738 89877 64332102
Hallucination 62.05 18.49 7 76746 72781 64349198
Application site erythema 60.89 18.49 48 76705 4641 64417338
Walking distance test abnormal 60.26 18.49 25 76728 693 64421286
Blood glucose increased 59.75 18.49 21 76732 98052 64323927
Intentional product misuse 59.07 18.49 8 76745 72287 64349692
Emergency care examination 57.63 18.49 14 76739 57 64421922
Nasopharyngitis 56.94 18.49 414 76339 195659 64226320
Depression 56.02 18.49 82 76671 183209 64238770
Suicide attempt 55.38 18.49 9 76744 70998 64350981
Anaphylactic reaction 55.16 18.49 8 76745 68656 64353323
Syncope 54.81 18.49 348 76405 157287 64264692
Blood creatine phosphokinase increased 54.28 18.49 4 76749 58554 64363425
Deep vein thrombosis 53.82 18.49 29 76724 105153 64316826
Pulmonary embolism 53.59 18.49 57 76696 146299 64275680
Wrong technique in product usage process 53.54 18.49 7 76746 64967 64357012
Catheter site dryness 53.00 18.49 12 76741 33 64421946
Mobility decreased 52.95 18.49 18 76735 85822 64336157
Metabolic acidosis 51.06 18.49 11 76742 70947 64351032
Glossodynia 50.91 18.49 8 76745 64688 64357291
Injection site erythema 50.89 18.49 11 76742 70789 64351190
Thyroidectomy 50.85 18.49 23 76730 790 64421189
Bradycardia 50.44 18.49 40 76713 118179 64303800
Drug reaction with eosinophilia and systemic symptoms 49.42 18.49 4 76749 54213 64367766
Hyperglycaemia 49.21 18.49 7 76746 60961 64361018
Epistaxis 49.05 18.49 239 76514 97892 64324087
Depressed level of consciousness 48.65 18.49 18 76735 81418 64340561
Coronary artery disease 48.64 18.49 7 76746 60426 64361553
Pericarditis 48.58 18.49 8 76745 62508 64359471
Presyncope 48.47 18.49 120 76633 34969 64387010
Discomfort 48.11 18.49 18 76735 80860 64341119
Seizure 47.80 18.49 78 76675 166814 64255165
Osteoarthritis 47.27 18.49 9 76744 63327 64358652
Application site rash 46.51 18.49 29 76724 1925 64420054
Suicidal ideation 46.50 18.49 11 76742 66531 64355448
Gait disturbance 46.07 18.49 84 76669 172071 64249908
Lung assist device therapy 45.90 18.49 13 76740 106 64421873
Dysphagia 45.75 18.49 36 76717 106776 64315203
Agitation 45.74 18.49 24 76729 88343 64333636
Balloon atrial septostomy 45.58 18.49 13 76740 109 64421870
Blood potassium decreased 45.46 18.49 128 76625 40271 64381708
Immunoglobulin G4 related disease 45.37 18.49 13 76740 111 64421868
Dizziness 45.32 18.49 741 76012 429422 63992557
Catheter site induration 45.24 18.49 11 76742 45 64421934
Multiple allergies 44.33 18.49 44 76709 5770 64416209
Acute myocardial infarction 44.08 18.49 14 76739 69704 64352275
Tri-iodothyronine increased 44.06 18.49 14 76739 175 64421804
Catheter site mass 43.95 18.49 11 76742 52 64421927
Hyperkalaemia 43.42 18.49 34 76719 101095 64320884
Lactic acidosis 43.21 18.49 10 76743 61400 64360579
Cardiac failure high output 43.14 18.49 15 76738 252 64421727
Maternal exposure during pregnancy 42.75 18.49 31 76722 95853 64326126
Suture related complication 42.39 18.49 15 76738 266 64421713
Pulmonary arterial pressure abnormal 42.02 18.49 19 76734 652 64421327
Delirium 41.83 18.49 15 76738 69179 64352800
Hypersensitivity 41.71 18.49 109 76644 196343 64225636
Clostridium difficile infection 41.11 18.49 115 76638 36048 64385931
Acute right ventricular failure 40.95 18.49 15 76738 295 64421684
Staphylococcal infection 40.82 18.49 143 76610 50535 64371444
Cognitive disorder 40.75 18.49 8 76745 55079 64366900
Psoriatic arthropathy 39.99 18.49 3 76750 43278 64378701
Angioedema 39.83 18.49 12 76741 61809 64360170
Disease complication 39.68 18.49 36 76717 4219 64417760
Catheter site nodule 39.66 18.49 10 76743 49 64421930
Blood pressure systolic increased 39.17 18.49 6 76747 49447 64372532
Catheter site urticaria 38.93 18.49 9 76744 28 64421951
Cerebrovascular accident 38.74 18.49 65 76688 137518 64284461
Impaired healing 38.49 18.49 12 76741 60461 64361518
Infusion site rash 38.49 18.49 21 76732 1085 64420894
Application site hypersensitivity 38.28 18.49 14 76739 274 64421705
Aggression 38.04 18.49 5 76748 46227 64375752
Catheter site bruise 38.00 18.49 14 76739 280 64421699
Infusion site pain 37.95 18.49 54 76699 10343 64411636
Sedation 37.95 18.49 3 76750 41459 64380520
Catheter site hypersensitivity 37.88 18.49 11 76742 99 64421880
Injury 37.69 18.49 10 76743 55982 64365997
Balance disorder 37.59 18.49 27 76726 83899 64338080
Blood pressure fluctuation 37.40 18.49 8 76745 51863 64370116
Pneumonia 37.39 18.49 900 75853 558676 63863303
Therapeutic procedure 37.27 18.49 18 76735 719 64421260
Cough 36.97 18.49 534 76219 301614 64120365
Hepatocellular injury 36.96 18.49 5 76748 45230 64376749
Urinary retention 36.70 18.49 7 76746 49194 64372785
Cholestasis 36.57 18.49 5 76748 44867 64377112
Orthostatic hypotension 36.27 18.49 6 76747 46732 64375247
Platelet transfusion 36.00 18.49 24 76729 1787 64420192
Biopsy bone marrow 35.90 18.49 14 76739 329 64421650
General physical health deterioration 35.80 18.49 124 76629 204301 64217678
Catheter site oedema 35.36 18.49 10 76743 81 64421898
Injection site swelling 35.18 18.49 4 76749 41349 64380630
Drug-induced liver injury 35.07 18.49 7 76746 47636 64374343
Disturbance in attention 34.88 18.49 4 76749 41070 64380909
C-reactive protein increased 34.69 18.49 37 76716 94872 64327107
Infusion site pruritus 34.54 18.49 27 76726 2579 64419400
Helicobacter infection 34.50 18.49 3 76750 38359 64383620
Agranulocytosis 34.35 18.49 3 76750 38226 64383753
Cholecystectomy 34.28 18.49 45 76708 7987 64413992
Hypokalaemia 33.94 18.49 58 76695 121845 64300134
Catheter site erosion 33.10 18.49 9 76744 62 64421917
Ear discomfort 32.97 18.49 42 76711 7238 64414741
Tracheostomy 32.82 18.49 19 76734 1101 64420878
Dysarthria 32.46 18.49 15 76738 59391 64362588
Congestive hepatopathy 32.03 18.49 31 76722 3942 64418037
Cardiac output increased 31.68 18.49 11 76742 184 64421795
Catheter site thrombosis 31.57 18.49 11 76742 186 64421793
Chest tube insertion 31.40 18.49 10 76743 126 64421853
Catheterisation cardiac abnormal 31.01 18.49 12 76741 276 64421703
Right ventricular dilatation 30.80 18.49 20 76733 1425 64420554
Dyskinesia 30.69 18.49 5 76748 39383 64382596
Endotracheal intubation 30.67 18.49 30 76723 3865 64418114
Interstitial lung disease 30.55 18.49 43 76710 97689 64324290
Haematuria 30.45 18.49 17 76736 60454 64361525
Duodenal ulcer perforation 30.35 18.49 3 76750 34622 64387357
Mineral supplementation 30.35 18.49 16 76737 771 64421208
Ventilation perfusion mismatch 30.16 18.49 12 76741 298 64421681
Wound 30.03 18.49 28 76725 76449 64345530
Retching 29.89 18.49 60 76693 15196 64406783
Drug level increased 29.88 18.49 3 76750 34193 64387786
Pulmonary capillary haemangiomatosis 29.82 18.49 8 76745 52 64421927
Right ventricular dysfunction 29.57 18.49 23 76730 2180 64419799
Endarterectomy 29.54 18.49 12 76741 315 64421664
Catheter site granuloma 29.44 18.49 8 76745 55 64421924
Biopsy liver 29.25 18.49 14 76739 548 64421431
Urticaria 28.83 18.49 85 76668 147232 64274747
Blood lactate dehydrogenase increased 28.65 18.49 3 76750 33075 64388904
Arthralgia 28.63 18.49 363 76390 441897 63980082
Dysentery 28.47 18.49 16 76737 876 64421103
Therapeutic embolisation 28.43 18.49 13 76740 458 64421521
Drug resistance 28.40 18.49 4 76749 35098 64386881
Brain natriuretic peptide increased 28.39 18.49 40 76713 7593 64414386
Drug delivery system malfunction 28.33 18.49 13 76740 462 64421517
Decreased appetite 28.25 18.49 481 76272 280808 64141171
Swollen tongue 28.24 18.49 4 76749 34950 64387029
Pruritus 28.18 18.49 237 76516 312163 64109816
Micrococcus test positive 28.18 18.49 6 76747 11 64421968
Mechanical ventilation 28.02 18.49 23 76730 2355 64419624
Mouth ulceration 27.95 18.49 3 76750 32441 64389538
Goitre 27.93 18.49 32 76721 4941 64417038
Caesarean section 27.90 18.49 49 76704 11225 64410754
Plasma cell myeloma 27.83 18.49 10 76743 46065 64375914
Seasonal allergy 27.78 18.49 50 76703 11676 64410303
Chest discomfort 27.51 18.49 234 76519 115872 64306107
Systemic-pulmonary artery shunt 27.48 18.49 7 76746 36 64421943
Pulmonary haemorrhage 27.43 18.49 53 76700 13056 64408923
Renal impairment 27.08 18.49 77 76676 134940 64287039
Hospice care 26.95 18.49 39 76714 7586 64414393
Paraesthesia 26.77 18.49 77 76676 134445 64287534
Epilepsy 26.71 18.49 4 76749 33527 64388452
Tremor 26.56 18.49 89 76664 148141 64273838
Diabetes mellitus 26.50 18.49 24 76729 66450 64355529
Cerebral infarction 26.38 18.49 8 76745 41036 64380943
Silent thyroiditis 26.29 18.49 9 76744 144 64421835
Infusion site discharge 26.24 18.49 13 76740 549 64421430
Cardioversion 26.00 18.49 20 76733 1865 64420114
Culture positive 25.88 18.49 16 76737 1046 64420933
Colonoscopy 25.73 18.49 19 76734 1666 64420313
Hepatitis 25.70 18.49 11 76742 45571 64376408
Biopsy lymph gland 25.63 18.49 8 76745 94 64421885
Lower respiratory tract infection 25.44 18.49 46 76707 94568 64327411
COVID-19 25.40 18.49 24 76729 65116 64356863
Blood creatinine increased 25.39 18.49 80 76673 135702 64286277
Hypocalcaemia 25.32 18.49 9 76744 41744 64380235
Liver injury 25.20 18.49 3 76750 29929 64392050
Diabetic ketoacidosis 25.11 18.49 3 76750 29842 64392137
Altered state of consciousness 25.07 18.49 7 76746 37895 64384084
Asthma 24.98 18.49 47 76706 95178 64326801
Encephalopathy 24.96 18.49 20 76733 58799 64363180
Cor pulmonale 24.74 18.49 20 76733 2005 64419974
Abnormal behaviour 24.62 18.49 5 76748 33617 64388362
Disease recurrence 24.55 18.49 4 76749 31506 64390473
Hypomagnesaemia 24.54 18.49 7 76746 37369 64384610
Muscular weakness 24.53 18.49 74 76679 127264 64294715
Feeling abnormal 24.52 18.49 255 76498 133347 64288632
Sleep disorder 24.47 18.49 21 76732 59688 64362291
Ischaemic stroke 24.23 18.49 3 76750 29032 64392947
Device related thrombosis 24.22 18.49 20 76733 2065 64419914
Atrial septal defect repair 24.13 18.49 11 76742 385 64421594
Hepatic steatosis 24.02 18.49 4 76749 31003 64390976
Jaundice 23.91 18.49 14 76739 48498 64373481
Application site odour 23.86 18.49 6 76747 29 64421950
Catheter site abscess 23.86 18.49 6 76747 29 64421950
Dry mouth 23.86 18.49 22 76731 60396 64361583
First bite syndrome 23.70 18.49 6 76747 30 64421949
Cardiac flutter 23.60 18.49 27 76726 4162 64417817
Sinus disorder 23.54 18.49 58 76695 16850 64405129
Cardiac operation 23.47 18.49 27 76726 4187 64417792
Application site reaction 23.30 18.49 13 76740 702 64421277
Abdominal pain upper 23.25 18.49 314 76439 174716 64247263
Injection site pruritus 23.20 18.49 8 76745 37818 64384161
Spinal cord ischaemia 23.14 18.49 8 76745 132 64421847
Acute respiratory failure 23.09 18.49 119 76634 49815 64372164
Cardiac disorder 23.08 18.49 129 76624 55687 64366292
Biopsy thyroid gland 22.94 18.49 4 76749 0 64421979
Aphasia 22.86 18.49 10 76743 40896 64381083
Thyroxine free increased 22.81 18.49 15 76738 1092 64420887
Female sterilisation 22.71 18.49 9 76744 221 64421758
Application site vesicles 22.69 18.49 16 76737 1306 64420673
Myelodysplastic syndrome 22.65 18.49 3 76750 27576 64394403
Suture insertion 22.50 18.49 8 76745 144 64421835
Speech disorder 22.46 18.49 15 76738 48426 64373553
Osteoporosis 22.41 18.49 11 76742 42069 64379910
Dizziness postural 22.36 18.49 41 76712 9711 64412268
Dizziness exertional 22.20 18.49 11 76742 465 64421514
Neuropathy peripheral 22.14 18.49 69 76684 117456 64304523
Catheter site scar 22.02 18.49 5 76748 14 64421965
Diuretic therapy 21.95 18.49 8 76745 155 64421824
Transaminases increased 21.79 18.49 13 76740 44581 64377398
Concomitant disease progression 21.77 18.49 23 76730 3246 64418733
Loss of personal independence in daily activities 21.55 18.49 33 76720 72421 64349558
Intra-abdominal fluid collection 21.53 18.49 21 76732 2696 64419283
Emotional distress 21.46 18.49 8 76745 36030 64385949
Dialysis 21.43 18.49 56 76697 16864 64405115
Device use error 21.29 18.49 32 76721 6439 64415540
Wound treatment 21.22 18.49 8 76745 171 64421808
Fibromyalgia 21.16 18.49 8 76745 35723 64386256
Acute hepatic failure 21.07 18.49 3 76750 26109 64395870
Exercise tolerance decreased 21.04 18.49 35 76718 7675 64414304
Ventricular assist device insertion 20.96 18.49 6 76747 51 64421928
Upper respiratory tract congestion 20.85 18.49 19 76734 2239 64419740
Pneumonia aspiration 20.67 18.49 24 76729 59247 64362732
Ear infection 20.56 18.49 68 76685 23336 64398643
Proteinuria 20.56 18.49 4 76749 27719 64394260
Vertigo 20.47 18.49 24 76729 58987 64362992
Jugular vein distension 20.40 18.49 15 76738 1307 64420672
Cardiomyopathy 20.25 18.49 3 76750 25353 64396626
Drug titration 20.17 18.49 4 76749 4 64421975
Culture negative 20.17 18.49 4 76749 4 64421975
Respiratory failure 20.12 18.49 286 76467 160897 64261082
Bacteraemia 20.02 18.49 74 76679 26837 64395142
Pulmonary alveolar haemorrhage 19.92 18.49 39 76714 9699 64412280
Pulmonary endarterectomy 19.83 18.49 8 76745 206 64421773
Pneumonitis 19.12 18.49 19 76734 50346 64371633
Injection site haemorrhage 19.10 18.49 3 76750 24275 64397704
Biopsy skin 19.03 18.49 6 76747 73 64421906
Irritability 18.98 18.49 10 76743 36736 64385243
Stent placement 18.97 18.49 28 76725 5543 64416436
Hypoaesthesia 18.95 18.49 93 76660 139015 64282964
Pancreatitis acute 18.91 18.49 14 76739 42841 64379138
Middle ear effusion 18.81 18.49 17 76736 1982 64419997
Localised oedema 18.77 18.49 32 76721 7159 64414820
Body temperature decreased 18.69 18.49 4 76749 25924 64396055
Chronic respiratory failure 18.54 18.49 19 76734 2587 64419392
Pulmonary artery dilatation 18.53 18.49 9 76744 364 64421615

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AC09 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
FDA CS M0017817 Prostaglandins I
FDA PE N0000009909 Vasodilation
FDA EPC N0000175416 Prostacycline Vasodilator
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pulmonary arterial hypertension indication 11399002
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Pulmonary hypertension indication 70995007 DOID:6432
Common cold indication 82272006 DOID:10459
Pulmonary edema contraindication 19242006 DOID:11396
Chronic heart failure contraindication 48447003
Blood coagulation disorder contraindication 64779008 DOID:1247




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.75 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin E2 receptor EP1 subtype GPCR AGONIST Ki 4.80 IUPHAR IUPHAR
Prostacyclin receptor GPCR AGONIST Ki 7.80 IUPHAR CHEMBL
P2Y purinoceptor 12 GPCR WOMBAT-PK
Prostaglandin E2 receptor EP4 subtype GPCR AGONIST Ki 5.10 IUPHAR

External reference:

IDSource
4024020 VUID
N0000022025 NUI
D00106 KEGG_DRUG
61849-14-7 SECONDARY_CAS_RN
4020958 VANDF
4024020 VANDF
C0033567 UMLSCUI
CHEBI:15552 CHEBI
CHEMBL1139 ChEMBL_ID
DB01240 DRUGBANK_ID
CHEMBL962 ChEMBL_ID
D011464 MESH_DESCRIPTOR_UI
5282411 PUBCHEM_CID
4725 INN_ID
DCR9Z582X0 UNII
104463 RXNORM
137029 MMSL
29551 MMSL
4669 MMSL
d03842 MMSL
003963 NDDF
003964 NDDF
108593000 SNOMEDCT_US
108594006 SNOMEDCT_US
372513003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FLOLAN HUMAN PRESCRIPTION DRUG LABEL 1 0173-0517 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 0.50 mg INTRAVENOUS NDA 25 sections
FLOLAN HUMAN PRESCRIPTION DRUG LABEL 1 0173-0519 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1.50 mg INTRAVENOUS NDA 25 sections
Epoprostenol Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0703-1985 INJECTION, POWDER, FOR SOLUTION 0.50 mg INTRAVENOUS ANDA 23 sections
Epoprostenol Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0703-1995 INJECTION, POWDER, FOR SOLUTION 1.50 mg INTRAVENOUS ANDA 23 sections
epoprostenol Human Prescription Drug Label 1 62756-059 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 0.50 mg INTRAVENOUS ANDA 25 sections
epoprostenol Human Prescription Drug Label 1 62756-060 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1.50 mg INTRAVENOUS ANDA 25 sections
Veletri HUMAN PRESCRIPTION DRUG LABEL 1 66215-402 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1.50 mg INTRAVENOUS NDA 28 sections
Veletri HUMAN PRESCRIPTION DRUG LABEL 1 66215-403 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 0.50 mg INTRAVENOUS NDA 28 sections