Stem definition | Drug id | CAS RN |
---|---|---|
prostaglandins | 1034 | 35121-78-9 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 20, 1995 | FDA | GLAXOSMITHKLINE LLC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pain in jaw | 3032.15 | 18.15 | 1315 | 65284 | 37113 | 50501412 |
Catheter site erythema | 1912.80 | 18.15 | 527 | 66072 | 3435 | 50535090 |
Catheter management | 1569.00 | 18.15 | 417 | 66182 | 2322 | 50536203 |
Catheter site pruritus | 1426.39 | 18.15 | 362 | 66237 | 1625 | 50536900 |
Device related infection | 1377.76 | 18.15 | 630 | 65969 | 20105 | 50518420 |
Flushing | 1251.15 | 18.15 | 886 | 65713 | 66129 | 50472396 |
Right ventricular failure | 1116.06 | 18.15 | 502 | 66097 | 15391 | 50523134 |
Catheter site discharge | 1096.49 | 18.15 | 290 | 66309 | 1578 | 50536947 |
Catheter site pain | 1082.64 | 18.15 | 335 | 66264 | 3427 | 50535098 |
Dyspnoea exertional | 1010.83 | 18.15 | 701 | 65898 | 50532 | 50487993 |
Catheter site infection | 978.65 | 18.15 | 320 | 66279 | 3966 | 50534559 |
Fluid retention | 945.57 | 18.15 | 670 | 65929 | 49979 | 50488546 |
Dyspnoea | 873.54 | 18.15 | 2093 | 64506 | 545515 | 49993010 |
Device leakage | 842.55 | 18.15 | 310 | 66289 | 5568 | 50532957 |
Device alarm issue | 779.03 | 18.15 | 208 | 66391 | 1180 | 50537345 |
Lung transplant | 702.25 | 18.15 | 225 | 66374 | 2600 | 50535925 |
Drug ineffective | 684.36 | 18.15 | 128 | 66471 | 819205 | 49719320 |
Catheter site haemorrhage | 666.61 | 18.15 | 216 | 66383 | 2594 | 50535931 |
Hypervolaemia | 665.90 | 18.15 | 416 | 66183 | 25083 | 50513442 |
Catheter placement | 662.36 | 18.15 | 199 | 66400 | 1825 | 50536700 |
Central venous catheterisation | 635.32 | 18.15 | 195 | 66404 | 1935 | 50536590 |
Catheter site rash | 618.80 | 18.15 | 153 | 66446 | 602 | 50537923 |
Hospitalisation | 603.24 | 18.15 | 584 | 66015 | 67353 | 50471172 |
Device occlusion | 590.25 | 18.15 | 241 | 66358 | 5782 | 50532743 |
Catheter site swelling | 535.81 | 18.15 | 154 | 66445 | 1190 | 50537335 |
Headache | 526.78 | 18.15 | 1658 | 64941 | 504877 | 50033648 |
Pulmonary hypertension | 486.45 | 18.15 | 381 | 66218 | 33036 | 50505489 |
Complication associated with device | 443.88 | 18.15 | 263 | 66336 | 14392 | 50524133 |
Catheter site inflammation | 414.33 | 18.15 | 109 | 66490 | 578 | 50537947 |
Diarrhoea | 396.17 | 18.15 | 1673 | 64926 | 586803 | 49951722 |
Pulmonary arterial hypertension | 365.37 | 18.15 | 263 | 66336 | 20056 | 50518469 |
Death | 352.40 | 18.15 | 1082 | 65517 | 324297 | 50214228 |
Catheter site irritation | 348.67 | 18.15 | 90 | 66509 | 437 | 50538088 |
Vascular device infection | 334.88 | 18.15 | 147 | 66452 | 4237 | 50534288 |
Off label use | 334.22 | 18.15 | 105 | 66494 | 474321 | 50064204 |
Device infusion issue | 319.82 | 18.15 | 104 | 66495 | 1263 | 50537262 |
Therapy change | 316.33 | 18.15 | 149 | 66450 | 5076 | 50533449 |
Transplant evaluation | 311.68 | 18.15 | 96 | 66503 | 964 | 50537561 |
Device dislocation | 299.15 | 18.15 | 239 | 66360 | 21307 | 50517218 |
Device breakage | 298.70 | 18.15 | 175 | 66424 | 9372 | 50529153 |
Palpitations | 297.64 | 18.15 | 483 | 66116 | 94023 | 50444502 |
Transfusion | 283.60 | 18.15 | 189 | 66410 | 12716 | 50525809 |
Catheter site vesicles | 246.27 | 18.15 | 61 | 66538 | 242 | 50538283 |
Oedema | 236.42 | 18.15 | 370 | 66229 | 69811 | 50468714 |
Dermatitis contact | 230.46 | 18.15 | 143 | 66456 | 8503 | 50530022 |
Toxicity to various agents | 230.42 | 18.15 | 12 | 66587 | 212487 | 50326038 |
Paracentesis | 227.80 | 18.15 | 73 | 66526 | 843 | 50537682 |
Ascites | 219.33 | 18.15 | 253 | 66346 | 35608 | 50502917 |
Catheter site related reaction | 216.85 | 18.15 | 68 | 66531 | 728 | 50537797 |
Emergency care | 209.61 | 18.15 | 67 | 66532 | 767 | 50537758 |
Infusion related reaction | 207.58 | 18.15 | 3 | 66596 | 169554 | 50368971 |
Pulmonary arterial pressure increased | 201.20 | 18.15 | 95 | 66504 | 3253 | 50535272 |
Rheumatoid arthritis | 200.52 | 18.15 | 18 | 66581 | 202532 | 50335993 |
Device connection issue | 199.62 | 18.15 | 59 | 66540 | 508 | 50538017 |
Alopecia | 193.44 | 18.15 | 43 | 66556 | 245004 | 50293521 |
Catheterisation cardiac | 192.96 | 18.15 | 98 | 66501 | 3942 | 50534583 |
Hypoxia | 192.62 | 18.15 | 284 | 66315 | 50839 | 50487686 |
Nausea | 188.56 | 18.15 | 1574 | 65025 | 703824 | 49834701 |
Chest pain | 185.95 | 18.15 | 583 | 66016 | 176299 | 50362226 |
Oxygen saturation decreased | 180.37 | 18.15 | 336 | 66263 | 72912 | 50465613 |
Catheter removal | 178.79 | 18.15 | 49 | 66550 | 311 | 50538214 |
Thrombosis in device | 174.68 | 18.15 | 81 | 66518 | 2660 | 50535865 |
Drug interaction | 172.44 | 18.15 | 28 | 66571 | 199593 | 50338932 |
Drug hypersensitivity | 172.00 | 18.15 | 58 | 66541 | 250952 | 50287573 |
Device physical property issue | 168.72 | 18.15 | 68 | 66531 | 1574 | 50536951 |
Joint swelling | 165.77 | 18.15 | 58 | 66541 | 245228 | 50293297 |
Medical device change | 165.10 | 18.15 | 45 | 66554 | 279 | 50538246 |
Device malfunction | 164.98 | 18.15 | 146 | 66453 | 14975 | 50523550 |
Therapeutic product effect decreased | 164.02 | 18.15 | 3 | 66596 | 136047 | 50402478 |
Arthropathy | 161.88 | 18.15 | 12 | 66587 | 157894 | 50380631 |
Treatment failure | 158.42 | 18.15 | 5 | 66594 | 137632 | 50400893 |
Neutropenia | 158.32 | 18.15 | 9 | 66590 | 147956 | 50390569 |
Oxygen consumption increased | 135.41 | 18.15 | 74 | 66525 | 3462 | 50535063 |
Central venous catheter removal | 133.50 | 18.15 | 39 | 66560 | 321 | 50538204 |
Drug intolerance | 126.89 | 18.15 | 65 | 66534 | 219039 | 50319486 |
Cardiac failure | 126.45 | 18.15 | 297 | 66302 | 75743 | 50462782 |
Haemoptysis | 124.78 | 18.15 | 161 | 66438 | 25412 | 50513113 |
Blood culture positive | 124.38 | 18.15 | 75 | 66524 | 4233 | 50534292 |
Glossodynia | 123.70 | 18.15 | 7 | 66592 | 115562 | 50422963 |
Catheter site scab | 123.35 | 18.15 | 32 | 66567 | 159 | 50538366 |
Application site pruritus | 123.12 | 18.15 | 71 | 66528 | 3688 | 50534837 |
Dyspnoea at rest | 122.43 | 18.15 | 70 | 66529 | 3577 | 50534948 |
Hypertension | 120.31 | 18.15 | 64 | 66535 | 211139 | 50327386 |
Musculoskeletal stiffness | 117.93 | 18.15 | 15 | 66584 | 128466 | 50410059 |
Product use issue | 116.31 | 18.15 | 27 | 66572 | 149448 | 50389077 |
Maternal exposure during pregnancy | 112.75 | 18.15 | 35 | 66564 | 159743 | 50378782 |
Febrile neutropenia | 110.77 | 18.15 | 4 | 66595 | 97663 | 50440862 |
Hepatic enzyme increased | 110.56 | 18.15 | 23 | 66576 | 137357 | 50401168 |
Hypotension | 110.30 | 18.15 | 605 | 65994 | 234864 | 50303661 |
Stomatitis | 105.86 | 18.15 | 7 | 66592 | 101337 | 50437188 |
Skin irritation | 105.69 | 18.15 | 85 | 66514 | 7642 | 50530883 |
Catheter site warmth | 105.29 | 18.15 | 29 | 66570 | 188 | 50538337 |
Device related sepsis | 104.23 | 18.15 | 62 | 66537 | 3413 | 50535112 |
Blood culture negative | 102.88 | 18.15 | 26 | 66573 | 114 | 50538411 |
Device issue | 100.99 | 18.15 | 128 | 66471 | 19844 | 50518681 |
Unevaluable event | 100.69 | 18.15 | 201 | 66398 | 45865 | 50492660 |
Abdominal distension | 98.36 | 18.15 | 263 | 66336 | 72640 | 50465885 |
Discomfort | 96.26 | 18.15 | 14 | 66585 | 108366 | 50430159 |
Product use in unapproved indication | 96.11 | 18.15 | 18 | 66581 | 115801 | 50422724 |
Oedema peripheral | 94.46 | 18.15 | 435 | 66164 | 157526 | 50380999 |
Injection site pain | 90.55 | 18.15 | 18 | 66581 | 111006 | 50427519 |
Nasal congestion | 89.72 | 18.15 | 204 | 66395 | 50916 | 50487609 |
Heart and lung transplant | 87.89 | 18.15 | 22 | 66577 | 92 | 50538433 |
Catheter site discolouration | 87.32 | 18.15 | 22 | 66577 | 95 | 50538430 |
Weight decreased | 87.05 | 18.15 | 543 | 66056 | 220702 | 50317823 |
Blood pressure increased | 85.61 | 18.15 | 34 | 66565 | 133098 | 50405427 |
Catheter site cellulitis | 85.34 | 18.15 | 25 | 66574 | 208 | 50538317 |
Staphylococcus test positive | 84.90 | 18.15 | 54 | 66545 | 3352 | 50535173 |
Abdominal cavity drainage | 84.64 | 18.15 | 28 | 66571 | 360 | 50538165 |
Scleroderma | 83.65 | 18.15 | 61 | 66538 | 4740 | 50533785 |
Therapeutic product effect incomplete | 83.20 | 18.15 | 11 | 66588 | 91504 | 50447021 |
Application site irritation | 82.48 | 18.15 | 41 | 66558 | 1574 | 50536951 |
Gastritis hypertrophic | 82.37 | 18.15 | 18 | 66581 | 34 | 50538491 |
Product administration interrupted | 80.19 | 18.15 | 35 | 66564 | 994 | 50537531 |
Catheter culture positive | 80.03 | 18.15 | 21 | 66578 | 110 | 50538415 |
Malaise | 79.68 | 18.15 | 731 | 65868 | 334801 | 50203724 |
Intentional product use issue | 75.60 | 18.15 | 7 | 66592 | 76911 | 50461614 |
Pulmonary veno-occlusive disease | 75.45 | 18.15 | 33 | 66566 | 942 | 50537583 |
White blood cell count decreased | 74.73 | 18.15 | 30 | 66569 | 116692 | 50421833 |
Transplant | 74.04 | 18.15 | 29 | 66570 | 621 | 50537904 |
Hyperthyroidism | 72.89 | 18.15 | 85 | 66514 | 12090 | 50526435 |
Pericarditis | 72.64 | 18.15 | 9 | 66590 | 78680 | 50459845 |
Psoriasis | 71.37 | 18.15 | 5 | 66594 | 68995 | 50469530 |
Disease progression | 67.97 | 18.15 | 278 | 66321 | 95588 | 50442937 |
Confusional state | 66.88 | 18.15 | 88 | 66511 | 185840 | 50352685 |
Wound | 66.41 | 18.15 | 28 | 66571 | 105766 | 50432759 |
Depression | 66.20 | 18.15 | 72 | 66527 | 165351 | 50373174 |
Drug abuse | 66 | 18.15 | 3 | 66596 | 59843 | 50478682 |
Syncope | 65.52 | 18.15 | 289 | 66310 | 102713 | 50435812 |
Osteoarthritis | 65.44 | 18.15 | 7 | 66592 | 68599 | 50469926 |
Pneumonia | 65.00 | 18.15 | 772 | 65827 | 377629 | 50160896 |
Inappropriate schedule of product administration | 64.42 | 18.15 | 9 | 66590 | 71822 | 50466703 |
Leukopenia | 64.13 | 18.15 | 7 | 66592 | 67521 | 50471004 |
Pericardial effusion | 63.69 | 18.15 | 118 | 66481 | 25471 | 50513054 |
Investigation | 63.66 | 18.15 | 34 | 66565 | 1518 | 50537007 |
Emergency care examination | 63.29 | 18.15 | 15 | 66584 | 47 | 50538478 |
Aspiration pleural cavity | 62.82 | 18.15 | 27 | 66572 | 738 | 50537787 |
Condition aggravated | 61.98 | 18.15 | 630 | 65969 | 296428 | 50242097 |
Walking distance test abnormal | 61.27 | 18.15 | 24 | 66575 | 514 | 50538011 |
Heart rate increased | 61.21 | 18.15 | 232 | 66367 | 77018 | 50461507 |
Acute kidney injury | 60.75 | 18.15 | 131 | 66468 | 227927 | 50310598 |
Cardiac ablation | 60.66 | 18.15 | 31 | 66568 | 1263 | 50537262 |
Vomiting | 60.45 | 18.15 | 895 | 65704 | 459863 | 50078662 |
Hypersensitivity | 60.34 | 18.15 | 120 | 66479 | 215041 | 50323484 |
Impaired healing | 59.72 | 18.15 | 10 | 66589 | 69776 | 50468749 |
Pulmonary oedema | 59.49 | 18.15 | 170 | 66429 | 48768 | 50489757 |
Pain in extremity | 59.48 | 18.15 | 584 | 66015 | 272281 | 50266244 |
Arthralgia | 59.36 | 18.15 | 337 | 66262 | 438365 | 50100160 |
Oxygen therapy | 58.74 | 18.15 | 34 | 66565 | 1778 | 50536747 |
Liver transplant | 58.68 | 18.15 | 36 | 66563 | 2096 | 50536429 |
Application site erythema | 58.02 | 18.15 | 48 | 66551 | 4490 | 50534035 |
Mobility decreased | 57.29 | 18.15 | 17 | 66582 | 79931 | 50458594 |
Systemic lupus erythematosus | 56.48 | 18.15 | 61 | 66538 | 140561 | 50397964 |
Somnolence | 56.09 | 18.15 | 73 | 66526 | 154912 | 50383613 |
Infusion site infection | 55.31 | 18.15 | 31 | 66568 | 1524 | 50537001 |
Pain | 53.96 | 18.15 | 495 | 66104 | 578408 | 49960117 |
Coma | 53.75 | 18.15 | 6 | 66593 | 56873 | 50481652 |
Injection site reaction | 53.61 | 18.15 | 3 | 66596 | 50029 | 50488496 |
Injection site erythema | 53.57 | 18.15 | 16 | 66583 | 74920 | 50463605 |
Presyncope | 53.36 | 18.15 | 106 | 66493 | 24092 | 50514433 |
Clostridium difficile infection | 53.19 | 18.15 | 109 | 66490 | 25330 | 50513195 |
Catheter site nodule | 53.01 | 18.15 | 13 | 66586 | 49 | 50538476 |
Wrong technique in product usage process | 52.09 | 18.15 | 6 | 66593 | 55504 | 50483021 |
Infusion site erythema | 49.05 | 18.15 | 59 | 66540 | 8668 | 50529857 |
Gait disturbance | 48.98 | 18.15 | 76 | 66523 | 149929 | 50388596 |
Acute right ventricular failure | 48.66 | 18.15 | 15 | 66584 | 151 | 50538374 |
Duodenal ulcer perforation | 48.06 | 18.15 | 3 | 66596 | 45608 | 50492917 |
Anaphylactic reaction | 47.94 | 18.15 | 7 | 66592 | 54048 | 50484477 |
Electrocardiogram QT prolonged | 47.72 | 18.15 | 6 | 66593 | 51880 | 50486645 |
Catheter site dermatitis | 47.60 | 18.15 | 12 | 66587 | 52 | 50538473 |
Overdose | 47.47 | 18.15 | 37 | 66562 | 99690 | 50438835 |
Suicidal ideation | 47.25 | 18.15 | 8 | 66591 | 55377 | 50483148 |
Intentional product misuse | 46.60 | 18.15 | 4 | 66595 | 46730 | 50491795 |
Platelet transfusion | 46.22 | 18.15 | 21 | 66578 | 657 | 50537868 |
Decreased appetite | 46.18 | 18.15 | 435 | 66164 | 200488 | 50338037 |
Blood potassium decreased | 45.54 | 18.15 | 129 | 66470 | 36816 | 50501709 |
Application site hypersensitivity | 45.33 | 18.15 | 15 | 66584 | 193 | 50538332 |
Suicide attempt | 45.19 | 18.15 | 7 | 66592 | 51725 | 50486800 |
Catheter site extravasation | 44.93 | 18.15 | 16 | 66583 | 260 | 50538265 |
Staphylococcal infection | 44.53 | 18.15 | 125 | 66474 | 35491 | 50503034 |
Ventilation perfusion mismatch | 43.98 | 18.15 | 15 | 66584 | 213 | 50538312 |
Catheter site induration | 43.20 | 18.15 | 11 | 66588 | 50 | 50538475 |
Immunoglobulin G4 related disease | 43.03 | 18.15 | 11 | 66588 | 51 | 50538474 |
Right ventricular dilatation | 42.21 | 18.15 | 22 | 66577 | 934 | 50537591 |
Catheter site erosion | 41.86 | 18.15 | 11 | 66588 | 58 | 50538467 |
Pulmonary haemorrhage | 41.69 | 18.15 | 47 | 66552 | 6445 | 50532080 |
Hallucination | 41.47 | 18.15 | 6 | 66593 | 46651 | 50491874 |
Disease complication | 41.04 | 18.15 | 32 | 66567 | 2750 | 50535775 |
Dizziness | 40.79 | 18.15 | 661 | 65938 | 345708 | 50192817 |
Catheter site hypersensitivity | 40.73 | 18.15 | 12 | 66587 | 102 | 50538423 |
Pulmonary arterial pressure abnormal | 40.34 | 18.15 | 17 | 66582 | 442 | 50538083 |
Seizure | 40.14 | 18.15 | 58 | 66541 | 117816 | 50420709 |
Blood glucose increased | 39.99 | 18.15 | 22 | 66577 | 71302 | 50467223 |
Pruritus | 39.82 | 18.15 | 215 | 66384 | 283353 | 50255172 |
Injury | 39.73 | 18.15 | 8 | 66591 | 48917 | 50489608 |
Epistaxis | 39.55 | 18.15 | 178 | 66421 | 63776 | 50474749 |
Hypoglycaemia | 39.11 | 18.15 | 11 | 66588 | 53570 | 50484955 |
Pancytopenia | 38.95 | 18.15 | 32 | 66567 | 83998 | 50454527 |
Catheter site bruise | 38.75 | 18.15 | 15 | 66584 | 311 | 50538214 |
Lower respiratory tract infection | 38.54 | 18.15 | 41 | 66558 | 95160 | 50443365 |
Concomitant disease aggravated | 37.99 | 18.15 | 50 | 66549 | 8041 | 50530484 |
Pulmonary embolism | 37.72 | 18.15 | 47 | 66552 | 101657 | 50436868 |
Cardiac failure high output | 37.64 | 18.15 | 14 | 66585 | 259 | 50538266 |
Cough | 37.34 | 18.15 | 483 | 66116 | 240781 | 50297744 |
Depressed level of consciousness | 37.30 | 18.15 | 11 | 66588 | 51942 | 50486583 |
Nasopharyngitis | 37.25 | 18.15 | 403 | 66196 | 192524 | 50346001 |
Respiratory failure | 37.15 | 18.15 | 226 | 66373 | 90955 | 50447570 |
Application site rash | 36.71 | 18.15 | 28 | 66571 | 2329 | 50536196 |
Endotracheal intubation | 36.69 | 18.15 | 27 | 66572 | 2127 | 50536398 |
Balance disorder | 36.45 | 18.15 | 24 | 66575 | 70566 | 50467959 |
Myocardial infarction | 36.42 | 18.15 | 38 | 66561 | 88989 | 50449536 |
Deep vein thrombosis | 36.42 | 18.15 | 26 | 66573 | 73278 | 50465247 |
Therapeutic embolisation | 36.22 | 18.15 | 12 | 66587 | 155 | 50538370 |
Hyponatraemia | 36.10 | 18.15 | 44 | 66555 | 96095 | 50442430 |
Thyroidectomy | 36.04 | 18.15 | 20 | 66579 | 964 | 50537561 |
Suture related complication | 35.74 | 18.15 | 12 | 66587 | 162 | 50538363 |
Dysphagia | 35.34 | 18.15 | 30 | 66569 | 77488 | 50461037 |
Catheter site oedema | 35.15 | 18.15 | 9 | 66590 | 42 | 50538483 |
Lung assist device therapy | 34.81 | 18.15 | 10 | 66589 | 77 | 50538448 |
Cognitive disorder | 34.23 | 18.15 | 8 | 66591 | 44115 | 50494410 |
Catheter site urticaria | 33.77 | 18.15 | 8 | 66591 | 25 | 50538500 |
Ear discomfort | 33.73 | 18.15 | 43 | 66556 | 6701 | 50531824 |
First bite syndrome | 33.67 | 18.15 | 7 | 66592 | 9 | 50538516 |
Abortion spontaneous | 33.57 | 18.15 | 7 | 66592 | 41765 | 50496760 |
Catheter site dryness | 33.08 | 18.15 | 8 | 66591 | 28 | 50538497 |
Cerebrovascular accident | 32.81 | 18.15 | 46 | 66553 | 94634 | 50443891 |
C-reactive protein increased | 32.47 | 18.15 | 24 | 66575 | 66450 | 50472075 |
Chest discomfort | 32.36 | 18.15 | 221 | 66378 | 92501 | 50446024 |
Irritable bowel syndrome | 31.66 | 18.15 | 14 | 66585 | 51427 | 50487098 |
Urticaria | 31.57 | 18.15 | 78 | 66521 | 129483 | 50409042 |
Bacteraemia | 31.55 | 18.15 | 63 | 66536 | 14370 | 50524155 |
Osteoporosis | 31.32 | 18.15 | 10 | 66589 | 44869 | 50493656 |
Pulmonary alveolar haemorrhage | 30.84 | 18.15 | 32 | 66567 | 3995 | 50534530 |
Mineral supplementation | 30.62 | 18.15 | 16 | 66583 | 683 | 50537842 |
Atrial flutter | 30.58 | 18.15 | 47 | 66552 | 8716 | 50529809 |
Blood pressure systolic increased | 30.50 | 18.15 | 5 | 66594 | 35444 | 50503081 |
Dizziness postural | 30.45 | 18.15 | 39 | 66560 | 6106 | 50532419 |
Biopsy liver | 29.76 | 18.15 | 13 | 66586 | 370 | 50538155 |
Fibromyalgia | 29.70 | 18.15 | 11 | 66588 | 44967 | 50493558 |
Infusion site pruritus | 29.64 | 18.15 | 31 | 66568 | 3906 | 50534619 |
Catheter site thrombosis | 29.51 | 18.15 | 10 | 66589 | 139 | 50538386 |
Hyperglycaemia | 29.46 | 18.15 | 6 | 66593 | 36399 | 50502126 |
Bradycardia | 29.28 | 18.15 | 25 | 66574 | 64401 | 50474124 |
Female sterilisation | 29.05 | 18.15 | 14 | 66585 | 502 | 50538023 |
Congestive hepatopathy | 29.05 | 18.15 | 25 | 66574 | 2469 | 50536056 |
Catheterisation cardiac abnormal | 29.01 | 18.15 | 11 | 66588 | 215 | 50538310 |
Systemic-pulmonary artery shunt | 28.84 | 18.15 | 7 | 66592 | 25 | 50538500 |
Paraesthesia | 28.82 | 18.15 | 73 | 66526 | 120170 | 50418355 |
Device related thrombosis | 28.36 | 18.15 | 19 | 66580 | 1288 | 50537237 |
Injection site pruritus | 28.21 | 18.15 | 9 | 66590 | 40402 | 50498123 |
Caesarean section | 28.08 | 18.15 | 63 | 66536 | 15576 | 50522949 |
Product deposit | 27.94 | 18.15 | 10 | 66589 | 165 | 50538360 |
Hypoaesthesia | 27.70 | 18.15 | 81 | 66518 | 127176 | 50411349 |
Sleep disorder | 27.57 | 18.15 | 21 | 66578 | 57262 | 50481263 |
Right ventricular dysfunction | 27.49 | 18.15 | 20 | 66579 | 1548 | 50536977 |
Loss of personal independence in daily activities | 27.43 | 18.15 | 31 | 66568 | 70019 | 50468506 |
Urinary tract infection | 27.11 | 18.15 | 178 | 66421 | 223842 | 50314683 |
Application site odour | 26.95 | 18.15 | 7 | 66592 | 35 | 50538490 |
Concomitant disease progression | 26.92 | 18.15 | 22 | 66577 | 2023 | 50536502 |
Knee arthroplasty | 26.83 | 18.15 | 7 | 66592 | 35839 | 50502686 |
Tri-iodothyronine increased | 26.77 | 18.15 | 9 | 66590 | 122 | 50538403 |
No adverse event | 26.22 | 18.15 | 6 | 66593 | 33572 | 50504953 |
Balloon atrial septostomy | 26.18 | 18.15 | 8 | 66591 | 78 | 50538447 |
Coronary artery disease | 26.01 | 18.15 | 4 | 66595 | 29722 | 50508803 |
Echocardiogram abnormal | 25.70 | 18.15 | 17 | 66582 | 1128 | 50537397 |
Culture positive | 25.46 | 18.15 | 12 | 66587 | 409 | 50538116 |
Biopsy bone marrow | 25.41 | 18.15 | 11 | 66588 | 306 | 50538219 |
Jugular vein distension | 25.29 | 18.15 | 15 | 66584 | 821 | 50537704 |
Mechanical ventilation | 25.16 | 18.15 | 17 | 66582 | 1169 | 50537356 |
Agitation | 25.15 | 18.15 | 20 | 66579 | 53364 | 50485161 |
Tracheostomy | 25.05 | 18.15 | 13 | 66586 | 547 | 50537978 |
Blood pressure fluctuation | 24.97 | 18.15 | 8 | 66591 | 35815 | 50502710 |
Multiple allergies | 24.89 | 18.15 | 42 | 66557 | 8421 | 50530104 |
Catheter site abscess | 24.81 | 18.15 | 6 | 66593 | 21 | 50538504 |
Emotional distress | 24.76 | 18.15 | 4 | 66595 | 28659 | 50509866 |
Swollen tongue | 24.72 | 18.15 | 4 | 66595 | 28626 | 50509899 |
General physical health deterioration | 24.67 | 18.15 | 100 | 66499 | 142334 | 50396191 |
Hospice care | 24.56 | 18.15 | 34 | 66565 | 5738 | 50532787 |
Cholecystectomy | 24.54 | 18.15 | 44 | 66555 | 9259 | 50529266 |
Tremor | 24.38 | 18.15 | 74 | 66525 | 114829 | 50423696 |
Terminal state | 24.27 | 18.15 | 21 | 66578 | 2089 | 50536436 |
Urinary retention | 24.15 | 18.15 | 3 | 66596 | 26187 | 50512338 |
Asthma | 24.01 | 18.15 | 51 | 66548 | 89286 | 50449239 |
Biopsy lymph gland | 23.61 | 18.15 | 6 | 66593 | 27 | 50538498 |
Orthostatic hypotension | 23.56 | 18.15 | 5 | 66594 | 29476 | 50509049 |
Disturbance in attention | 23.52 | 18.15 | 6 | 66593 | 31180 | 50507345 |
Therapeutic procedure | 23.49 | 18.15 | 14 | 66585 | 773 | 50537752 |
Femur fracture | 23.36 | 18.15 | 10 | 66589 | 37454 | 50501071 |
Cardioversion | 23.31 | 18.15 | 16 | 66583 | 1129 | 50537396 |
Contusion | 23.27 | 18.15 | 73 | 66526 | 112110 | 50426415 |
Infusion site rash | 23.26 | 18.15 | 17 | 66582 | 1325 | 50537200 |
Dry mouth | 22.95 | 18.15 | 24 | 66575 | 56154 | 50482371 |
Arthritis | 22.90 | 18.15 | 50 | 66549 | 86671 | 50451854 |
Application site reaction | 22.79 | 18.15 | 13 | 66586 | 661 | 50537864 |
Oral pain | 22.76 | 18.15 | 3 | 66596 | 25030 | 50513495 |
Upper respiratory tract congestion | 22.66 | 18.15 | 19 | 66580 | 1810 | 50536715 |
Lactic acidosis | 22.29 | 18.15 | 8 | 66591 | 33347 | 50505178 |
Stent placement | 22.26 | 18.15 | 25 | 66574 | 3413 | 50535112 |
Hypokalaemia | 22.20 | 18.15 | 52 | 66547 | 87940 | 50450585 |
Cardiac output increased | 22.08 | 18.15 | 8 | 66591 | 137 | 50538388 |
Drug-induced liver injury | 21.98 | 18.15 | 5 | 66594 | 28090 | 50510435 |
Blister | 21.94 | 18.15 | 50 | 66549 | 85368 | 50453157 |
Myalgia | 21.84 | 18.15 | 255 | 66344 | 124064 | 50414461 |
Metabolic acidosis | 21.72 | 18.15 | 12 | 66587 | 38813 | 50499712 |
Vertigo | 21.33 | 18.15 | 22 | 66577 | 51810 | 50486715 |
Brain natriuretic peptide increased | 21.29 | 18.15 | 28 | 66571 | 4499 | 50534026 |
Dysentery | 21.17 | 18.15 | 13 | 66586 | 758 | 50537767 |
Delirium | 21.09 | 18.15 | 12 | 66587 | 38180 | 50500345 |
Dry eye | 20.94 | 18.15 | 8 | 66591 | 32087 | 50506438 |
Cardiac flutter | 20.85 | 18.15 | 24 | 66575 | 3366 | 50535159 |
Endarterectomy | 20.84 | 18.15 | 8 | 66591 | 162 | 50538363 |
Acute respiratory failure | 20.80 | 18.15 | 84 | 66515 | 28698 | 50509827 |
Pulmonary artery dilatation | 20.77 | 18.15 | 9 | 66590 | 251 | 50538274 |
Therapeutic response decreased | 20.65 | 18.15 | 19 | 66580 | 47212 | 50491313 |
Insomnia | 20.61 | 18.15 | 140 | 66459 | 174725 | 50363800 |
Angioedema | 20.57 | 18.15 | 12 | 66587 | 37664 | 50500861 |
Aphasia | 20.51 | 18.15 | 6 | 66593 | 28488 | 50510037 |
Adrenocorticotropic hormone deficiency | 20.51 | 18.15 | 9 | 66590 | 259 | 50538266 |
Suture insertion | 20.42 | 18.15 | 7 | 66592 | 101 | 50538424 |
Catheter site mass | 20.35 | 18.15 | 5 | 66594 | 19 | 50538506 |
Culture negative | 20.30 | 18.15 | 4 | 66595 | 3 | 50538522 |
Catheter site scar | 20.30 | 18.15 | 4 | 66595 | 3 | 50538522 |
Muscular weakness | 20.29 | 18.15 | 61 | 66538 | 94952 | 50443573 |
Supraventricular tachycardia | 20.17 | 18.15 | 49 | 66550 | 12752 | 50525773 |
Speech disorder | 19.87 | 18.15 | 11 | 66588 | 35537 | 50502988 |
Dyskinesia | 19.81 | 18.15 | 6 | 66593 | 27855 | 50510670 |
N-terminal prohormone brain natriuretic peptide increased | 19.63 | 18.15 | 17 | 66582 | 1693 | 50536832 |
Drain placement | 19.59 | 18.15 | 6 | 66593 | 59 | 50538466 |
Hepatocellular injury | 19.55 | 18.15 | 5 | 66594 | 25942 | 50512583 |
Pituitary enlargement | 19.42 | 18.15 | 5 | 66594 | 24 | 50538501 |
Chronic right ventricular failure | 19.42 | 18.15 | 5 | 66594 | 24 | 50538501 |
Inflammation | 19.37 | 18.15 | 28 | 66571 | 56884 | 50481641 |
Cardiac output decreased | 19.33 | 18.15 | 13 | 66586 | 887 | 50537638 |
Pulmonary capillary haemangiomatosis | 19.25 | 18.15 | 5 | 66594 | 25 | 50538500 |
Infusion site pain | 19.18 | 18.15 | 47 | 66552 | 12299 | 50526226 |
Visual impairment | 19.17 | 18.15 | 38 | 66561 | 68237 | 50470288 |
Cardiac disorder | 19.09 | 18.15 | 109 | 66490 | 42870 | 50495655 |
Cholestasis | 18.94 | 18.15 | 5 | 66594 | 25396 | 50513129 |
Diabetes mellitus | 18.87 | 18.15 | 22 | 66577 | 49011 | 50489514 |
Biopsy skin | 18.82 | 18.15 | 6 | 66593 | 68 | 50538457 |
Irritability | 18.69 | 18.15 | 7 | 66592 | 28419 | 50510106 |
Plasma cell myeloma | 18.53 | 18.15 | 9 | 66590 | 31313 | 50507212 |
Right atrial dilatation | 18.51 | 18.15 | 11 | 66588 | 604 | 50537921 |
Silent thyroiditis | 18.51 | 18.15 | 6 | 66593 | 72 | 50538453 |
Cor pulmonale | 18.19 | 18.15 | 17 | 66582 | 1870 | 50536655 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pain in jaw | 1063.13 | 24.88 | 354 | 16548 | 11287 | 29546338 |
Catheter management | 604.15 | 24.88 | 131 | 16771 | 713 | 29556912 |
Catheter site erythema | 468.96 | 24.88 | 114 | 16788 | 1097 | 29556528 |
Right ventricular failure | 459.66 | 24.88 | 172 | 16730 | 7718 | 29549907 |
Fluid retention | 400.92 | 24.88 | 217 | 16685 | 23343 | 29534282 |
Device related infection | 361.31 | 24.88 | 177 | 16725 | 15459 | 29542166 |
Catheter site pruritus | 342.67 | 24.88 | 69 | 16833 | 242 | 29557383 |
Device alarm issue | 299.58 | 24.88 | 69 | 16833 | 513 | 29557112 |
Lung transplant | 293.54 | 24.88 | 85 | 16817 | 1671 | 29555954 |
Catheter placement | 287.90 | 24.88 | 69 | 16833 | 621 | 29557004 |
Headache | 264.55 | 24.88 | 404 | 16498 | 173603 | 29384022 |
Dyspnoea | 262.98 | 24.88 | 575 | 16327 | 326157 | 29231468 |
Device occlusion | 257.91 | 24.88 | 103 | 16799 | 5505 | 29552120 |
Flushing | 252.47 | 24.88 | 174 | 16728 | 28818 | 29528807 |
Catheter site discharge | 223.14 | 24.88 | 54 | 16848 | 508 | 29557117 |
Catheter site infection | 222.34 | 24.88 | 71 | 16831 | 1961 | 29555664 |
Hypervolaemia | 213.55 | 24.88 | 130 | 16772 | 17415 | 29540210 |
Dyspnoea exertional | 206.11 | 24.88 | 169 | 16733 | 36321 | 29521304 |
Catheter site pain | 197.45 | 24.88 | 57 | 16845 | 1107 | 29556518 |
Pulmonary hypertension | 179.37 | 24.88 | 119 | 16783 | 18489 | 29539136 |
Device dislocation | 176.90 | 24.88 | 74 | 16828 | 4453 | 29553172 |
Complication associated with device | 176.87 | 24.88 | 77 | 16825 | 5114 | 29552511 |
Catheter site haemorrhage | 165.75 | 24.88 | 57 | 16845 | 1991 | 29555634 |
Central venous catheterisation | 159.25 | 24.88 | 47 | 16855 | 989 | 29556636 |
Catheter site rash | 149.76 | 24.88 | 32 | 16870 | 160 | 29557465 |
Device leakage | 144.47 | 24.88 | 64 | 16838 | 4431 | 29553194 |
Pulmonary arterial hypertension | 124.80 | 24.88 | 68 | 16834 | 7381 | 29550244 |
Oxygen saturation decreased | 123.49 | 24.88 | 140 | 16762 | 44797 | 29512828 |
Hospitalisation | 115.85 | 24.88 | 137 | 16765 | 45851 | 29511774 |
Catheter removal | 110.84 | 24.88 | 25 | 16877 | 167 | 29557458 |
Catheter site inflammation | 108.14 | 24.88 | 25 | 16877 | 189 | 29557436 |
Catheter site irritation | 104.86 | 24.88 | 22 | 16880 | 99 | 29557526 |
Medical device change | 102.90 | 24.88 | 21 | 16881 | 80 | 29557545 |
Transplant evaluation | 101.53 | 24.88 | 28 | 16874 | 457 | 29557168 |
Drug interaction | 95.80 | 24.88 | 4 | 16898 | 197381 | 29360244 |
Catheter site swelling | 94.55 | 24.88 | 24 | 16878 | 279 | 29557346 |
Paracentesis | 92.24 | 24.88 | 25 | 16877 | 381 | 29557244 |
Pulmonary veno-occlusive disease | 89.70 | 24.88 | 25 | 16877 | 425 | 29557200 |
Device infusion issue | 86.39 | 24.88 | 26 | 16876 | 586 | 29557039 |
Thrombosis in device | 85.71 | 24.88 | 40 | 16862 | 3124 | 29554501 |
Toxicity to various agents | 79.57 | 24.88 | 5 | 16897 | 173656 | 29383969 |
Therapy change | 77.12 | 24.88 | 35 | 16867 | 2563 | 29555062 |
Pain in extremity | 76.43 | 24.88 | 184 | 16718 | 110249 | 29447376 |
Condition aggravated | 76.04 | 24.88 | 219 | 16683 | 146076 | 29411549 |
Oedema | 75.64 | 24.88 | 104 | 16798 | 40379 | 29517246 |
Ascites | 74.41 | 24.88 | 98 | 16804 | 36521 | 29521104 |
Device connection issue | 73.66 | 24.88 | 20 | 16882 | 307 | 29557318 |
Transfusion | 73.50 | 24.88 | 48 | 16854 | 7250 | 29550375 |
Device breakage | 73.32 | 24.88 | 30 | 16872 | 1704 | 29555921 |
Vascular device infection | 72.01 | 24.88 | 33 | 16869 | 2472 | 29555153 |
Heart and lung transplant | 71.77 | 24.88 | 15 | 16887 | 66 | 29557559 |
Blood culture positive | 63.68 | 24.88 | 37 | 16865 | 4540 | 29553085 |
Neutropenia | 62.76 | 24.88 | 3 | 16899 | 131708 | 29425917 |
Hypoxia | 61.86 | 24.88 | 103 | 16799 | 47276 | 29510349 |
Death | 61.16 | 24.88 | 368 | 16534 | 341716 | 29215909 |
Concomitant disease aggravated | 60.80 | 24.88 | 37 | 16865 | 4941 | 29552684 |
Device physical property issue | 60.25 | 24.88 | 20 | 16882 | 625 | 29557000 |
Diarrhoea | 58.88 | 24.88 | 357 | 16545 | 332341 | 29225284 |
Oxygen consumption increased | 56.93 | 24.88 | 23 | 16879 | 1264 | 29556361 |
Abdominal distension | 56.21 | 24.88 | 97 | 16805 | 45814 | 29511811 |
Catheterisation cardiac | 54.57 | 24.88 | 26 | 16876 | 2127 | 29555498 |
Pulmonary arterial pressure increased | 53.59 | 24.88 | 21 | 16881 | 1065 | 29556560 |
Device malfunction | 53.47 | 24.88 | 42 | 16860 | 8465 | 29549160 |
Drug ineffective | 52.74 | 24.88 | 79 | 16823 | 363091 | 29194534 |
Product deposit | 52.50 | 24.88 | 15 | 16887 | 280 | 29557345 |
Febrile neutropenia | 52.07 | 24.88 | 3 | 16899 | 112237 | 29445388 |
Haemoptysis | 51.88 | 24.88 | 75 | 16827 | 30475 | 29527150 |
Off label use | 50.19 | 24.88 | 59 | 16843 | 300741 | 29256884 |
Liver transplant | 49.80 | 24.88 | 25 | 16877 | 2291 | 29555334 |
Device related sepsis | 48.04 | 24.88 | 25 | 16877 | 2470 | 29555155 |
Catheter site vesicles | 46.27 | 24.88 | 9 | 16893 | 25 | 29557600 |
Blood culture negative | 40.67 | 24.88 | 8 | 16894 | 24 | 29557601 |
Device issue | 37.62 | 24.88 | 33 | 16869 | 7747 | 29549878 |
Nausea | 37.08 | 24.88 | 287 | 16615 | 288968 | 29268657 |
Cardiac failure | 36.63 | 24.88 | 114 | 16788 | 79173 | 29478452 |
Dermatitis contact | 35.92 | 24.88 | 22 | 16880 | 2970 | 29554655 |
Oxygen therapy | 35.83 | 24.88 | 14 | 16888 | 704 | 29556921 |
Catheter site scab | 33.73 | 24.88 | 6 | 16896 | 8 | 29557617 |
Palpitations | 33.67 | 24.88 | 64 | 16838 | 32540 | 29525085 |
Abdominal cavity drainage | 33.44 | 24.88 | 11 | 16891 | 334 | 29557291 |
Pulmonary endarterectomy | 33.27 | 24.88 | 8 | 16894 | 73 | 29557552 |
Spinal cord ischaemia | 33.07 | 24.88 | 8 | 16894 | 75 | 29557550 |
Micrococcus test positive | 32.57 | 24.88 | 6 | 16896 | 11 | 29557614 |
Pulmonary oedema | 32.53 | 24.88 | 74 | 16828 | 42661 | 29514964 |
White blood cell count decreased | 31.42 | 24.88 | 5 | 16897 | 83357 | 29474268 |
Catheter culture positive | 30.50 | 24.88 | 6 | 16896 | 18 | 29557607 |
Catheter site dermatitis | 29.99 | 24.88 | 5 | 16897 | 3 | 29557622 |
Catheter site dryness | 29.99 | 24.88 | 5 | 16897 | 3 | 29557622 |
Catheter site mass | 29.80 | 24.88 | 6 | 16896 | 21 | 29557604 |
Oedema peripheral | 29.29 | 24.88 | 127 | 16775 | 103430 | 29454195 |
Catheter site related reaction | 28.12 | 24.88 | 9 | 16893 | 250 | 29557375 |
Central venous catheter removal | 27.75 | 24.88 | 6 | 16896 | 32 | 29557593 |
Disease progression | 27.55 | 24.88 | 106 | 16796 | 81810 | 29475815 |
Catheter site extravasation | 27.29 | 24.88 | 7 | 16895 | 85 | 29557540 |
Epistaxis | 26.36 | 24.88 | 77 | 16825 | 51627 | 29505998 |
Nasal congestion | 25.90 | 24.88 | 42 | 16860 | 18837 | 29538788 |
Overdose | 25.54 | 24.88 | 7 | 16895 | 79812 | 29477813 |
Catheter site warmth | 25.23 | 24.88 | 6 | 16896 | 52 | 29557573 |
Myocardial infarction | 25.16 | 24.88 | 16 | 16886 | 110280 | 29447345 |
Staphylococcus test positive | 25.15 | 24.88 | 17 | 16885 | 2716 | 29554909 |
Balloon atrial septostomy | 24.94 | 24.88 | 5 | 16897 | 17 | 29557608 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pain in jaw | 3603.22 | 18.49 | 1469 | 75284 | 39286 | 64382693 |
Catheter site erythema | 2106.52 | 18.49 | 581 | 76172 | 4268 | 64417711 |
Catheter management | 1848.38 | 18.49 | 485 | 76268 | 2870 | 64419109 |
Catheter site pruritus | 1579.36 | 18.49 | 391 | 76362 | 1757 | 64420222 |
Device related infection | 1527.71 | 18.49 | 740 | 76013 | 29886 | 64392093 |
Right ventricular failure | 1388.28 | 18.49 | 621 | 76132 | 20850 | 64401129 |
Flushing | 1350.05 | 18.49 | 950 | 75803 | 77698 | 64344281 |
Fluid retention | 1224.91 | 18.49 | 805 | 75948 | 58801 | 64363178 |
Catheter site discharge | 1200.95 | 18.49 | 317 | 76436 | 1924 | 64420055 |
Catheter site pain | 1143.02 | 18.49 | 355 | 76398 | 4107 | 64417872 |
Catheter site infection | 1069.89 | 18.49 | 358 | 76395 | 5335 | 64416644 |
Dyspnoea exertional | 991.07 | 18.49 | 769 | 75984 | 72961 | 64349018 |
Dyspnoea | 987.83 | 18.49 | 2438 | 74315 | 716236 | 63705743 |
Device alarm issue | 963.48 | 18.49 | 257 | 76496 | 1633 | 64420346 |
Device leakage | 932.24 | 18.49 | 356 | 76397 | 7910 | 64414069 |
Catheter placement | 883.04 | 18.49 | 257 | 76496 | 2336 | 64419643 |
Lung transplant | 862.85 | 18.49 | 281 | 76472 | 3827 | 64418152 |
Headache | 788.04 | 18.49 | 1855 | 74898 | 527612 | 63894367 |
Hypervolaemia | 776.10 | 18.49 | 513 | 76240 | 37772 | 64384207 |
Device occlusion | 728.81 | 18.49 | 314 | 76439 | 9599 | 64412380 |
Central venous catheterisation | 722.73 | 18.49 | 223 | 76530 | 2518 | 64419461 |
Catheter site haemorrhage | 719.37 | 18.49 | 252 | 76501 | 4339 | 64417640 |
Catheter site rash | 666.62 | 18.49 | 167 | 76586 | 794 | 64421185 |
Complication associated with device | 597.48 | 18.49 | 312 | 76441 | 14768 | 64407211 |
Pulmonary hypertension | 572.75 | 18.49 | 447 | 76306 | 42692 | 64379287 |
Catheter site swelling | 565.84 | 18.49 | 164 | 76589 | 1466 | 64420513 |
Hospitalisation | 552.33 | 18.49 | 557 | 76196 | 74650 | 64347329 |
Drug ineffective | 503.72 | 18.49 | 187 | 76566 | 840060 | 63581919 |
Catheter site inflammation | 484.01 | 18.49 | 129 | 76624 | 816 | 64421163 |
Device dislocation | 439.24 | 18.49 | 288 | 76465 | 20890 | 64401089 |
Diarrhoea | 420.42 | 18.49 | 1833 | 74920 | 720871 | 63701108 |
Pulmonary arterial hypertension | 410.41 | 18.49 | 296 | 76457 | 25071 | 64396908 |
Device breakage | 389.81 | 18.49 | 196 | 76557 | 8559 | 64413420 |
Death | 375.93 | 18.49 | 1343 | 75410 | 481362 | 63940617 |
Device infusion issue | 372.16 | 18.49 | 121 | 76632 | 1637 | 64420342 |
Catheter site irritation | 367.33 | 18.49 | 93 | 76660 | 465 | 64421514 |
Toxicity to various agents | 364.96 | 18.49 | 16 | 76737 | 363497 | 64058482 |
Off label use | 360.17 | 18.49 | 152 | 76601 | 632654 | 63789325 |
Transplant evaluation | 332.99 | 18.49 | 108 | 76645 | 1449 | 64420530 |
Drug interaction | 330.15 | 18.49 | 27 | 76726 | 362056 | 64059923 |
Transfusion | 309.54 | 18.49 | 218 | 76535 | 17776 | 64404203 |
Palpitations | 308.57 | 18.49 | 491 | 76262 | 103997 | 64317982 |
Oedema | 288.09 | 18.49 | 444 | 76309 | 91491 | 64330488 |
Paracentesis | 284.25 | 18.49 | 91 | 76662 | 1168 | 64420811 |
Vascular device infection | 274.08 | 18.49 | 138 | 76615 | 6042 | 64415937 |
Therapy change | 271.72 | 18.49 | 139 | 76614 | 6295 | 64415684 |
Nausea | 267.39 | 18.49 | 1720 | 75033 | 784080 | 63637899 |
Dermatitis contact | 262.05 | 18.49 | 152 | 76601 | 8848 | 64413131 |
Catheter removal | 246.50 | 18.49 | 68 | 76685 | 498 | 64421481 |
Neutropenia | 242.14 | 18.49 | 10 | 76743 | 239614 | 64182365 |
Oxygen saturation decreased | 240.55 | 18.49 | 446 | 76307 | 106730 | 64315249 |
Catheter site vesicles | 238.03 | 18.49 | 59 | 76694 | 266 | 64421713 |
Medical device change | 237.82 | 18.49 | 64 | 76689 | 422 | 64421557 |
Thrombosis in device | 235.98 | 18.49 | 117 | 76636 | 4954 | 64417025 |
Ascites | 225.16 | 18.49 | 321 | 76432 | 61680 | 64360299 |
Catheterisation cardiac | 222.53 | 18.49 | 111 | 76642 | 4762 | 64417217 |
Catheter site related reaction | 221.29 | 18.49 | 71 | 76682 | 918 | 64421061 |
Device connection issue | 221.13 | 18.49 | 69 | 76684 | 810 | 64421169 |
Device physical property issue | 209.03 | 18.49 | 83 | 76670 | 2050 | 64419929 |
Device malfunction | 208.88 | 18.49 | 171 | 76582 | 17462 | 64404517 |
Pulmonary arterial pressure increased | 206.59 | 18.49 | 100 | 76653 | 4016 | 64417963 |
Emergency care | 205.17 | 18.49 | 66 | 76687 | 861 | 64421118 |
Febrile neutropenia | 192.38 | 18.49 | 7 | 76746 | 187650 | 64234329 |
Hypoxia | 184.32 | 18.49 | 356 | 76397 | 87793 | 64334186 |
Infusion related reaction | 176.39 | 18.49 | 4 | 76749 | 164463 | 64257516 |
Blood culture positive | 165.53 | 18.49 | 108 | 76645 | 7760 | 64414219 |
Chest pain | 159.05 | 18.49 | 628 | 76125 | 235352 | 64186627 |
Oxygen consumption increased | 153.97 | 18.49 | 85 | 76668 | 4496 | 64417483 |
Central venous catheter removal | 145.72 | 18.49 | 42 | 76711 | 367 | 64421612 |
Device related sepsis | 144.62 | 18.49 | 85 | 76668 | 5070 | 64416909 |
Acute kidney injury | 139.68 | 18.49 | 199 | 76554 | 449041 | 63972938 |
Catheter site scab | 138.56 | 18.49 | 35 | 76718 | 173 | 64421806 |
Device issue | 137.99 | 18.49 | 152 | 76601 | 22496 | 64399483 |
Rheumatoid arthritis | 137.20 | 18.49 | 17 | 76736 | 164277 | 64257702 |
Heart and lung transplant | 135.80 | 18.49 | 34 | 76719 | 161 | 64421818 |
Drug abuse | 135.43 | 18.49 | 5 | 76748 | 132369 | 64289610 |
Application site pruritus | 133.81 | 18.49 | 71 | 76682 | 3468 | 64418511 |
Abdominal distension | 131.44 | 18.49 | 327 | 76426 | 95667 | 64326312 |
Blood culture negative | 130.66 | 18.49 | 33 | 76720 | 163 | 64421816 |
Haemoptysis | 127.80 | 18.49 | 218 | 76535 | 48830 | 64373149 |
Pulmonary veno-occlusive disease | 127.61 | 18.49 | 52 | 76701 | 1376 | 64420603 |
Hypertension | 126.39 | 18.49 | 76 | 76677 | 259185 | 64162794 |
Product use in unapproved indication | 123.95 | 18.49 | 29 | 76724 | 176589 | 64245390 |
Therapeutic product effect decreased | 122.91 | 18.49 | 3 | 76750 | 115348 | 64306631 |
Drug hypersensitivity | 121.22 | 18.49 | 66 | 76687 | 237749 | 64184230 |
Unevaluable event | 116.81 | 18.49 | 213 | 76540 | 50276 | 64371703 |
Catheter site warmth | 115.68 | 18.49 | 32 | 76721 | 237 | 64421742 |
Oedema peripheral | 113.22 | 18.49 | 523 | 76230 | 209794 | 64212185 |
Skin irritation | 110.64 | 18.49 | 90 | 76663 | 9104 | 64412875 |
Treatment failure | 108.28 | 18.49 | 8 | 76745 | 116808 | 64305171 |
Stomatitis | 106.06 | 18.49 | 6 | 76747 | 109599 | 64312380 |
Pain in extremity | 105.00 | 18.49 | 668 | 76085 | 302417 | 64119562 |
Condition aggravated | 104.87 | 18.49 | 780 | 75973 | 371646 | 64050333 |
Arthropathy | 104.78 | 18.49 | 11 | 76742 | 120956 | 64301023 |
Malaise | 102.73 | 18.49 | 814 | 75939 | 395433 | 64026546 |
Dyspnoea at rest | 102.65 | 18.49 | 74 | 76679 | 6255 | 64415724 |
Abdominal cavity drainage | 102.64 | 18.49 | 37 | 76716 | 694 | 64421285 |
Nasal congestion | 102.24 | 18.49 | 222 | 76531 | 59436 | 64362543 |
Catheter culture positive | 100.59 | 18.49 | 27 | 76726 | 176 | 64421803 |
Cardiac failure | 98.68 | 18.49 | 364 | 76389 | 132009 | 64289970 |
Application site irritation | 96.72 | 18.49 | 44 | 76709 | 1532 | 64420447 |
Staphylococcus test positive | 96.15 | 18.49 | 68 | 76685 | 5577 | 64416402 |
White blood cell count decreased | 95.87 | 18.49 | 34 | 76719 | 157803 | 64264176 |
Joint swelling | 94.39 | 18.49 | 71 | 76682 | 215311 | 64206668 |
Scleroderma | 93.76 | 18.49 | 63 | 76690 | 4755 | 64417224 |
Alopecia | 93.52 | 18.49 | 40 | 76713 | 165650 | 64256329 |
Confusional state | 93.20 | 18.49 | 104 | 76649 | 261040 | 64160939 |
Hepatic enzyme increased | 91.82 | 18.49 | 21 | 76732 | 129922 | 64292057 |
Product use issue | 89.91 | 18.49 | 34 | 76719 | 151681 | 64270298 |
Musculoskeletal stiffness | 88.90 | 18.49 | 19 | 76734 | 123187 | 64298792 |
Leukopenia | 88.21 | 18.49 | 9 | 76744 | 101233 | 64320746 |
Overdose | 84.66 | 18.49 | 42 | 76711 | 159524 | 64262455 |
Gastritis hypertrophic | 84.18 | 18.49 | 18 | 76735 | 34 | 64421945 |
Weight decreased | 83.51 | 18.49 | 604 | 76149 | 285135 | 64136844 |
Catheter site discolouration | 82.61 | 18.49 | 21 | 76732 | 107 | 64421872 |
Catheter site cellulitis | 81.03 | 18.49 | 27 | 76726 | 396 | 64421583 |
Liver transplant | 80.81 | 18.49 | 54 | 76699 | 4038 | 64417941 |
Injection site pain | 80.75 | 18.49 | 17 | 76736 | 111391 | 64310588 |
Blood pressure increased | 80.71 | 18.49 | 53 | 76700 | 172499 | 64249480 |
Myocardial infarction | 78.83 | 18.49 | 50 | 76703 | 165771 | 64256208 |
Pancytopenia | 78.66 | 18.49 | 36 | 76717 | 143273 | 64278706 |
Coma | 78.42 | 18.49 | 7 | 76746 | 87608 | 64334371 |
Infusion site infection | 78.13 | 18.49 | 38 | 76715 | 1542 | 64420437 |
Intentional product use issue | 76.88 | 18.49 | 11 | 76742 | 95353 | 64326626 |
Inappropriate schedule of product administration | 75.92 | 18.49 | 10 | 76743 | 92276 | 64329703 |
Transplant | 75.15 | 18.49 | 31 | 76722 | 847 | 64421132 |
Somnolence | 74.96 | 18.49 | 79 | 76674 | 203566 | 64218413 |
Therapeutic product effect incomplete | 74.57 | 18.49 | 16 | 76737 | 103466 | 64318513 |
Heart rate increased | 74.07 | 18.49 | 272 | 76481 | 98403 | 64323576 |
Product administration interrupted | 73.74 | 18.49 | 33 | 76720 | 1105 | 64420874 |
Investigation | 73.53 | 18.49 | 41 | 76712 | 2211 | 64419768 |
Oxygen therapy | 72.84 | 18.49 | 41 | 76712 | 2252 | 64419727 |
Pulmonary oedema | 72.28 | 18.49 | 232 | 76521 | 78442 | 64343537 |
Disease progression | 72.27 | 18.49 | 347 | 76406 | 141333 | 64280646 |
Electrocardiogram QT prolonged | 72.05 | 18.49 | 6 | 76747 | 79442 | 64342537 |
Hyperthyroidism | 71.73 | 18.49 | 98 | 76655 | 18081 | 64403898 |
Product deposit | 70.63 | 18.49 | 24 | 76729 | 375 | 64421604 |
Infusion site erythema | 69.77 | 18.49 | 61 | 76692 | 6812 | 64415167 |
Concomitant disease aggravated | 69.50 | 18.49 | 77 | 76676 | 11465 | 64410514 |
Catheter site dermatitis | 69.25 | 18.49 | 17 | 76736 | 73 | 64421906 |
Cardiac ablation | 68.27 | 18.49 | 36 | 76717 | 1736 | 64420243 |
Hypotension | 67.81 | 18.49 | 722 | 76031 | 380252 | 64041727 |
Vomiting | 67.33 | 18.49 | 973 | 75780 | 550144 | 63871835 |
Drug intolerance | 66.89 | 18.49 | 75 | 76678 | 187917 | 64234062 |
Psoriasis | 66.18 | 18.49 | 5 | 76748 | 71698 | 64350281 |
Pericardial effusion | 66.02 | 18.49 | 145 | 76608 | 39109 | 64382870 |
Catheter site extravasation | 64.26 | 18.49 | 22 | 76731 | 352 | 64421627 |
Hyponatraemia | 63.56 | 18.49 | 50 | 76703 | 148289 | 64273690 |
Aspiration pleural cavity | 63.49 | 18.49 | 32 | 76721 | 1403 | 64420576 |
Hypoglycaemia | 62.56 | 18.49 | 15 | 76738 | 89877 | 64332102 |
Hallucination | 62.05 | 18.49 | 7 | 76746 | 72781 | 64349198 |
Application site erythema | 60.89 | 18.49 | 48 | 76705 | 4641 | 64417338 |
Walking distance test abnormal | 60.26 | 18.49 | 25 | 76728 | 693 | 64421286 |
Blood glucose increased | 59.75 | 18.49 | 21 | 76732 | 98052 | 64323927 |
Intentional product misuse | 59.07 | 18.49 | 8 | 76745 | 72287 | 64349692 |
Emergency care examination | 57.63 | 18.49 | 14 | 76739 | 57 | 64421922 |
Nasopharyngitis | 56.94 | 18.49 | 414 | 76339 | 195659 | 64226320 |
Depression | 56.02 | 18.49 | 82 | 76671 | 183209 | 64238770 |
Suicide attempt | 55.38 | 18.49 | 9 | 76744 | 70998 | 64350981 |
Anaphylactic reaction | 55.16 | 18.49 | 8 | 76745 | 68656 | 64353323 |
Syncope | 54.81 | 18.49 | 348 | 76405 | 157287 | 64264692 |
Blood creatine phosphokinase increased | 54.28 | 18.49 | 4 | 76749 | 58554 | 64363425 |
Deep vein thrombosis | 53.82 | 18.49 | 29 | 76724 | 105153 | 64316826 |
Pulmonary embolism | 53.59 | 18.49 | 57 | 76696 | 146299 | 64275680 |
Wrong technique in product usage process | 53.54 | 18.49 | 7 | 76746 | 64967 | 64357012 |
Catheter site dryness | 53.00 | 18.49 | 12 | 76741 | 33 | 64421946 |
Mobility decreased | 52.95 | 18.49 | 18 | 76735 | 85822 | 64336157 |
Metabolic acidosis | 51.06 | 18.49 | 11 | 76742 | 70947 | 64351032 |
Glossodynia | 50.91 | 18.49 | 8 | 76745 | 64688 | 64357291 |
Injection site erythema | 50.89 | 18.49 | 11 | 76742 | 70789 | 64351190 |
Thyroidectomy | 50.85 | 18.49 | 23 | 76730 | 790 | 64421189 |
Bradycardia | 50.44 | 18.49 | 40 | 76713 | 118179 | 64303800 |
Drug reaction with eosinophilia and systemic symptoms | 49.42 | 18.49 | 4 | 76749 | 54213 | 64367766 |
Hyperglycaemia | 49.21 | 18.49 | 7 | 76746 | 60961 | 64361018 |
Epistaxis | 49.05 | 18.49 | 239 | 76514 | 97892 | 64324087 |
Depressed level of consciousness | 48.65 | 18.49 | 18 | 76735 | 81418 | 64340561 |
Coronary artery disease | 48.64 | 18.49 | 7 | 76746 | 60426 | 64361553 |
Pericarditis | 48.58 | 18.49 | 8 | 76745 | 62508 | 64359471 |
Presyncope | 48.47 | 18.49 | 120 | 76633 | 34969 | 64387010 |
Discomfort | 48.11 | 18.49 | 18 | 76735 | 80860 | 64341119 |
Seizure | 47.80 | 18.49 | 78 | 76675 | 166814 | 64255165 |
Osteoarthritis | 47.27 | 18.49 | 9 | 76744 | 63327 | 64358652 |
Application site rash | 46.51 | 18.49 | 29 | 76724 | 1925 | 64420054 |
Suicidal ideation | 46.50 | 18.49 | 11 | 76742 | 66531 | 64355448 |
Gait disturbance | 46.07 | 18.49 | 84 | 76669 | 172071 | 64249908 |
Lung assist device therapy | 45.90 | 18.49 | 13 | 76740 | 106 | 64421873 |
Dysphagia | 45.75 | 18.49 | 36 | 76717 | 106776 | 64315203 |
Agitation | 45.74 | 18.49 | 24 | 76729 | 88343 | 64333636 |
Balloon atrial septostomy | 45.58 | 18.49 | 13 | 76740 | 109 | 64421870 |
Blood potassium decreased | 45.46 | 18.49 | 128 | 76625 | 40271 | 64381708 |
Immunoglobulin G4 related disease | 45.37 | 18.49 | 13 | 76740 | 111 | 64421868 |
Dizziness | 45.32 | 18.49 | 741 | 76012 | 429422 | 63992557 |
Catheter site induration | 45.24 | 18.49 | 11 | 76742 | 45 | 64421934 |
Multiple allergies | 44.33 | 18.49 | 44 | 76709 | 5770 | 64416209 |
Acute myocardial infarction | 44.08 | 18.49 | 14 | 76739 | 69704 | 64352275 |
Tri-iodothyronine increased | 44.06 | 18.49 | 14 | 76739 | 175 | 64421804 |
Catheter site mass | 43.95 | 18.49 | 11 | 76742 | 52 | 64421927 |
Hyperkalaemia | 43.42 | 18.49 | 34 | 76719 | 101095 | 64320884 |
Lactic acidosis | 43.21 | 18.49 | 10 | 76743 | 61400 | 64360579 |
Cardiac failure high output | 43.14 | 18.49 | 15 | 76738 | 252 | 64421727 |
Maternal exposure during pregnancy | 42.75 | 18.49 | 31 | 76722 | 95853 | 64326126 |
Suture related complication | 42.39 | 18.49 | 15 | 76738 | 266 | 64421713 |
Pulmonary arterial pressure abnormal | 42.02 | 18.49 | 19 | 76734 | 652 | 64421327 |
Delirium | 41.83 | 18.49 | 15 | 76738 | 69179 | 64352800 |
Hypersensitivity | 41.71 | 18.49 | 109 | 76644 | 196343 | 64225636 |
Clostridium difficile infection | 41.11 | 18.49 | 115 | 76638 | 36048 | 64385931 |
Acute right ventricular failure | 40.95 | 18.49 | 15 | 76738 | 295 | 64421684 |
Staphylococcal infection | 40.82 | 18.49 | 143 | 76610 | 50535 | 64371444 |
Cognitive disorder | 40.75 | 18.49 | 8 | 76745 | 55079 | 64366900 |
Psoriatic arthropathy | 39.99 | 18.49 | 3 | 76750 | 43278 | 64378701 |
Angioedema | 39.83 | 18.49 | 12 | 76741 | 61809 | 64360170 |
Disease complication | 39.68 | 18.49 | 36 | 76717 | 4219 | 64417760 |
Catheter site nodule | 39.66 | 18.49 | 10 | 76743 | 49 | 64421930 |
Blood pressure systolic increased | 39.17 | 18.49 | 6 | 76747 | 49447 | 64372532 |
Catheter site urticaria | 38.93 | 18.49 | 9 | 76744 | 28 | 64421951 |
Cerebrovascular accident | 38.74 | 18.49 | 65 | 76688 | 137518 | 64284461 |
Impaired healing | 38.49 | 18.49 | 12 | 76741 | 60461 | 64361518 |
Infusion site rash | 38.49 | 18.49 | 21 | 76732 | 1085 | 64420894 |
Application site hypersensitivity | 38.28 | 18.49 | 14 | 76739 | 274 | 64421705 |
Aggression | 38.04 | 18.49 | 5 | 76748 | 46227 | 64375752 |
Catheter site bruise | 38.00 | 18.49 | 14 | 76739 | 280 | 64421699 |
Infusion site pain | 37.95 | 18.49 | 54 | 76699 | 10343 | 64411636 |
Sedation | 37.95 | 18.49 | 3 | 76750 | 41459 | 64380520 |
Catheter site hypersensitivity | 37.88 | 18.49 | 11 | 76742 | 99 | 64421880 |
Injury | 37.69 | 18.49 | 10 | 76743 | 55982 | 64365997 |
Balance disorder | 37.59 | 18.49 | 27 | 76726 | 83899 | 64338080 |
Blood pressure fluctuation | 37.40 | 18.49 | 8 | 76745 | 51863 | 64370116 |
Pneumonia | 37.39 | 18.49 | 900 | 75853 | 558676 | 63863303 |
Therapeutic procedure | 37.27 | 18.49 | 18 | 76735 | 719 | 64421260 |
Cough | 36.97 | 18.49 | 534 | 76219 | 301614 | 64120365 |
Hepatocellular injury | 36.96 | 18.49 | 5 | 76748 | 45230 | 64376749 |
Urinary retention | 36.70 | 18.49 | 7 | 76746 | 49194 | 64372785 |
Cholestasis | 36.57 | 18.49 | 5 | 76748 | 44867 | 64377112 |
Orthostatic hypotension | 36.27 | 18.49 | 6 | 76747 | 46732 | 64375247 |
Platelet transfusion | 36.00 | 18.49 | 24 | 76729 | 1787 | 64420192 |
Biopsy bone marrow | 35.90 | 18.49 | 14 | 76739 | 329 | 64421650 |
General physical health deterioration | 35.80 | 18.49 | 124 | 76629 | 204301 | 64217678 |
Catheter site oedema | 35.36 | 18.49 | 10 | 76743 | 81 | 64421898 |
Injection site swelling | 35.18 | 18.49 | 4 | 76749 | 41349 | 64380630 |
Drug-induced liver injury | 35.07 | 18.49 | 7 | 76746 | 47636 | 64374343 |
Disturbance in attention | 34.88 | 18.49 | 4 | 76749 | 41070 | 64380909 |
C-reactive protein increased | 34.69 | 18.49 | 37 | 76716 | 94872 | 64327107 |
Infusion site pruritus | 34.54 | 18.49 | 27 | 76726 | 2579 | 64419400 |
Helicobacter infection | 34.50 | 18.49 | 3 | 76750 | 38359 | 64383620 |
Agranulocytosis | 34.35 | 18.49 | 3 | 76750 | 38226 | 64383753 |
Cholecystectomy | 34.28 | 18.49 | 45 | 76708 | 7987 | 64413992 |
Hypokalaemia | 33.94 | 18.49 | 58 | 76695 | 121845 | 64300134 |
Catheter site erosion | 33.10 | 18.49 | 9 | 76744 | 62 | 64421917 |
Ear discomfort | 32.97 | 18.49 | 42 | 76711 | 7238 | 64414741 |
Tracheostomy | 32.82 | 18.49 | 19 | 76734 | 1101 | 64420878 |
Dysarthria | 32.46 | 18.49 | 15 | 76738 | 59391 | 64362588 |
Congestive hepatopathy | 32.03 | 18.49 | 31 | 76722 | 3942 | 64418037 |
Cardiac output increased | 31.68 | 18.49 | 11 | 76742 | 184 | 64421795 |
Catheter site thrombosis | 31.57 | 18.49 | 11 | 76742 | 186 | 64421793 |
Chest tube insertion | 31.40 | 18.49 | 10 | 76743 | 126 | 64421853 |
Catheterisation cardiac abnormal | 31.01 | 18.49 | 12 | 76741 | 276 | 64421703 |
Right ventricular dilatation | 30.80 | 18.49 | 20 | 76733 | 1425 | 64420554 |
Dyskinesia | 30.69 | 18.49 | 5 | 76748 | 39383 | 64382596 |
Endotracheal intubation | 30.67 | 18.49 | 30 | 76723 | 3865 | 64418114 |
Interstitial lung disease | 30.55 | 18.49 | 43 | 76710 | 97689 | 64324290 |
Haematuria | 30.45 | 18.49 | 17 | 76736 | 60454 | 64361525 |
Duodenal ulcer perforation | 30.35 | 18.49 | 3 | 76750 | 34622 | 64387357 |
Mineral supplementation | 30.35 | 18.49 | 16 | 76737 | 771 | 64421208 |
Ventilation perfusion mismatch | 30.16 | 18.49 | 12 | 76741 | 298 | 64421681 |
Wound | 30.03 | 18.49 | 28 | 76725 | 76449 | 64345530 |
Retching | 29.89 | 18.49 | 60 | 76693 | 15196 | 64406783 |
Drug level increased | 29.88 | 18.49 | 3 | 76750 | 34193 | 64387786 |
Pulmonary capillary haemangiomatosis | 29.82 | 18.49 | 8 | 76745 | 52 | 64421927 |
Right ventricular dysfunction | 29.57 | 18.49 | 23 | 76730 | 2180 | 64419799 |
Endarterectomy | 29.54 | 18.49 | 12 | 76741 | 315 | 64421664 |
Catheter site granuloma | 29.44 | 18.49 | 8 | 76745 | 55 | 64421924 |
Biopsy liver | 29.25 | 18.49 | 14 | 76739 | 548 | 64421431 |
Urticaria | 28.83 | 18.49 | 85 | 76668 | 147232 | 64274747 |
Blood lactate dehydrogenase increased | 28.65 | 18.49 | 3 | 76750 | 33075 | 64388904 |
Arthralgia | 28.63 | 18.49 | 363 | 76390 | 441897 | 63980082 |
Dysentery | 28.47 | 18.49 | 16 | 76737 | 876 | 64421103 |
Therapeutic embolisation | 28.43 | 18.49 | 13 | 76740 | 458 | 64421521 |
Drug resistance | 28.40 | 18.49 | 4 | 76749 | 35098 | 64386881 |
Brain natriuretic peptide increased | 28.39 | 18.49 | 40 | 76713 | 7593 | 64414386 |
Drug delivery system malfunction | 28.33 | 18.49 | 13 | 76740 | 462 | 64421517 |
Decreased appetite | 28.25 | 18.49 | 481 | 76272 | 280808 | 64141171 |
Swollen tongue | 28.24 | 18.49 | 4 | 76749 | 34950 | 64387029 |
Pruritus | 28.18 | 18.49 | 237 | 76516 | 312163 | 64109816 |
Micrococcus test positive | 28.18 | 18.49 | 6 | 76747 | 11 | 64421968 |
Mechanical ventilation | 28.02 | 18.49 | 23 | 76730 | 2355 | 64419624 |
Mouth ulceration | 27.95 | 18.49 | 3 | 76750 | 32441 | 64389538 |
Goitre | 27.93 | 18.49 | 32 | 76721 | 4941 | 64417038 |
Caesarean section | 27.90 | 18.49 | 49 | 76704 | 11225 | 64410754 |
Plasma cell myeloma | 27.83 | 18.49 | 10 | 76743 | 46065 | 64375914 |
Seasonal allergy | 27.78 | 18.49 | 50 | 76703 | 11676 | 64410303 |
Chest discomfort | 27.51 | 18.49 | 234 | 76519 | 115872 | 64306107 |
Systemic-pulmonary artery shunt | 27.48 | 18.49 | 7 | 76746 | 36 | 64421943 |
Pulmonary haemorrhage | 27.43 | 18.49 | 53 | 76700 | 13056 | 64408923 |
Renal impairment | 27.08 | 18.49 | 77 | 76676 | 134940 | 64287039 |
Hospice care | 26.95 | 18.49 | 39 | 76714 | 7586 | 64414393 |
Paraesthesia | 26.77 | 18.49 | 77 | 76676 | 134445 | 64287534 |
Epilepsy | 26.71 | 18.49 | 4 | 76749 | 33527 | 64388452 |
Tremor | 26.56 | 18.49 | 89 | 76664 | 148141 | 64273838 |
Diabetes mellitus | 26.50 | 18.49 | 24 | 76729 | 66450 | 64355529 |
Cerebral infarction | 26.38 | 18.49 | 8 | 76745 | 41036 | 64380943 |
Silent thyroiditis | 26.29 | 18.49 | 9 | 76744 | 144 | 64421835 |
Infusion site discharge | 26.24 | 18.49 | 13 | 76740 | 549 | 64421430 |
Cardioversion | 26.00 | 18.49 | 20 | 76733 | 1865 | 64420114 |
Culture positive | 25.88 | 18.49 | 16 | 76737 | 1046 | 64420933 |
Colonoscopy | 25.73 | 18.49 | 19 | 76734 | 1666 | 64420313 |
Hepatitis | 25.70 | 18.49 | 11 | 76742 | 45571 | 64376408 |
Biopsy lymph gland | 25.63 | 18.49 | 8 | 76745 | 94 | 64421885 |
Lower respiratory tract infection | 25.44 | 18.49 | 46 | 76707 | 94568 | 64327411 |
COVID-19 | 25.40 | 18.49 | 24 | 76729 | 65116 | 64356863 |
Blood creatinine increased | 25.39 | 18.49 | 80 | 76673 | 135702 | 64286277 |
Hypocalcaemia | 25.32 | 18.49 | 9 | 76744 | 41744 | 64380235 |
Liver injury | 25.20 | 18.49 | 3 | 76750 | 29929 | 64392050 |
Diabetic ketoacidosis | 25.11 | 18.49 | 3 | 76750 | 29842 | 64392137 |
Altered state of consciousness | 25.07 | 18.49 | 7 | 76746 | 37895 | 64384084 |
Asthma | 24.98 | 18.49 | 47 | 76706 | 95178 | 64326801 |
Encephalopathy | 24.96 | 18.49 | 20 | 76733 | 58799 | 64363180 |
Cor pulmonale | 24.74 | 18.49 | 20 | 76733 | 2005 | 64419974 |
Abnormal behaviour | 24.62 | 18.49 | 5 | 76748 | 33617 | 64388362 |
Disease recurrence | 24.55 | 18.49 | 4 | 76749 | 31506 | 64390473 |
Hypomagnesaemia | 24.54 | 18.49 | 7 | 76746 | 37369 | 64384610 |
Muscular weakness | 24.53 | 18.49 | 74 | 76679 | 127264 | 64294715 |
Feeling abnormal | 24.52 | 18.49 | 255 | 76498 | 133347 | 64288632 |
Sleep disorder | 24.47 | 18.49 | 21 | 76732 | 59688 | 64362291 |
Ischaemic stroke | 24.23 | 18.49 | 3 | 76750 | 29032 | 64392947 |
Device related thrombosis | 24.22 | 18.49 | 20 | 76733 | 2065 | 64419914 |
Atrial septal defect repair | 24.13 | 18.49 | 11 | 76742 | 385 | 64421594 |
Hepatic steatosis | 24.02 | 18.49 | 4 | 76749 | 31003 | 64390976 |
Jaundice | 23.91 | 18.49 | 14 | 76739 | 48498 | 64373481 |
Application site odour | 23.86 | 18.49 | 6 | 76747 | 29 | 64421950 |
Catheter site abscess | 23.86 | 18.49 | 6 | 76747 | 29 | 64421950 |
Dry mouth | 23.86 | 18.49 | 22 | 76731 | 60396 | 64361583 |
First bite syndrome | 23.70 | 18.49 | 6 | 76747 | 30 | 64421949 |
Cardiac flutter | 23.60 | 18.49 | 27 | 76726 | 4162 | 64417817 |
Sinus disorder | 23.54 | 18.49 | 58 | 76695 | 16850 | 64405129 |
Cardiac operation | 23.47 | 18.49 | 27 | 76726 | 4187 | 64417792 |
Application site reaction | 23.30 | 18.49 | 13 | 76740 | 702 | 64421277 |
Abdominal pain upper | 23.25 | 18.49 | 314 | 76439 | 174716 | 64247263 |
Injection site pruritus | 23.20 | 18.49 | 8 | 76745 | 37818 | 64384161 |
Spinal cord ischaemia | 23.14 | 18.49 | 8 | 76745 | 132 | 64421847 |
Acute respiratory failure | 23.09 | 18.49 | 119 | 76634 | 49815 | 64372164 |
Cardiac disorder | 23.08 | 18.49 | 129 | 76624 | 55687 | 64366292 |
Biopsy thyroid gland | 22.94 | 18.49 | 4 | 76749 | 0 | 64421979 |
Aphasia | 22.86 | 18.49 | 10 | 76743 | 40896 | 64381083 |
Thyroxine free increased | 22.81 | 18.49 | 15 | 76738 | 1092 | 64420887 |
Female sterilisation | 22.71 | 18.49 | 9 | 76744 | 221 | 64421758 |
Application site vesicles | 22.69 | 18.49 | 16 | 76737 | 1306 | 64420673 |
Myelodysplastic syndrome | 22.65 | 18.49 | 3 | 76750 | 27576 | 64394403 |
Suture insertion | 22.50 | 18.49 | 8 | 76745 | 144 | 64421835 |
Speech disorder | 22.46 | 18.49 | 15 | 76738 | 48426 | 64373553 |
Osteoporosis | 22.41 | 18.49 | 11 | 76742 | 42069 | 64379910 |
Dizziness postural | 22.36 | 18.49 | 41 | 76712 | 9711 | 64412268 |
Dizziness exertional | 22.20 | 18.49 | 11 | 76742 | 465 | 64421514 |
Neuropathy peripheral | 22.14 | 18.49 | 69 | 76684 | 117456 | 64304523 |
Catheter site scar | 22.02 | 18.49 | 5 | 76748 | 14 | 64421965 |
Diuretic therapy | 21.95 | 18.49 | 8 | 76745 | 155 | 64421824 |
Transaminases increased | 21.79 | 18.49 | 13 | 76740 | 44581 | 64377398 |
Concomitant disease progression | 21.77 | 18.49 | 23 | 76730 | 3246 | 64418733 |
Loss of personal independence in daily activities | 21.55 | 18.49 | 33 | 76720 | 72421 | 64349558 |
Intra-abdominal fluid collection | 21.53 | 18.49 | 21 | 76732 | 2696 | 64419283 |
Emotional distress | 21.46 | 18.49 | 8 | 76745 | 36030 | 64385949 |
Dialysis | 21.43 | 18.49 | 56 | 76697 | 16864 | 64405115 |
Device use error | 21.29 | 18.49 | 32 | 76721 | 6439 | 64415540 |
Wound treatment | 21.22 | 18.49 | 8 | 76745 | 171 | 64421808 |
Fibromyalgia | 21.16 | 18.49 | 8 | 76745 | 35723 | 64386256 |
Acute hepatic failure | 21.07 | 18.49 | 3 | 76750 | 26109 | 64395870 |
Exercise tolerance decreased | 21.04 | 18.49 | 35 | 76718 | 7675 | 64414304 |
Ventricular assist device insertion | 20.96 | 18.49 | 6 | 76747 | 51 | 64421928 |
Upper respiratory tract congestion | 20.85 | 18.49 | 19 | 76734 | 2239 | 64419740 |
Pneumonia aspiration | 20.67 | 18.49 | 24 | 76729 | 59247 | 64362732 |
Ear infection | 20.56 | 18.49 | 68 | 76685 | 23336 | 64398643 |
Proteinuria | 20.56 | 18.49 | 4 | 76749 | 27719 | 64394260 |
Vertigo | 20.47 | 18.49 | 24 | 76729 | 58987 | 64362992 |
Jugular vein distension | 20.40 | 18.49 | 15 | 76738 | 1307 | 64420672 |
Cardiomyopathy | 20.25 | 18.49 | 3 | 76750 | 25353 | 64396626 |
Drug titration | 20.17 | 18.49 | 4 | 76749 | 4 | 64421975 |
Culture negative | 20.17 | 18.49 | 4 | 76749 | 4 | 64421975 |
Respiratory failure | 20.12 | 18.49 | 286 | 76467 | 160897 | 64261082 |
Bacteraemia | 20.02 | 18.49 | 74 | 76679 | 26837 | 64395142 |
Pulmonary alveolar haemorrhage | 19.92 | 18.49 | 39 | 76714 | 9699 | 64412280 |
Pulmonary endarterectomy | 19.83 | 18.49 | 8 | 76745 | 206 | 64421773 |
Pneumonitis | 19.12 | 18.49 | 19 | 76734 | 50346 | 64371633 |
Injection site haemorrhage | 19.10 | 18.49 | 3 | 76750 | 24275 | 64397704 |
Biopsy skin | 19.03 | 18.49 | 6 | 76747 | 73 | 64421906 |
Irritability | 18.98 | 18.49 | 10 | 76743 | 36736 | 64385243 |
Stent placement | 18.97 | 18.49 | 28 | 76725 | 5543 | 64416436 |
Hypoaesthesia | 18.95 | 18.49 | 93 | 76660 | 139015 | 64282964 |
Pancreatitis acute | 18.91 | 18.49 | 14 | 76739 | 42841 | 64379138 |
Middle ear effusion | 18.81 | 18.49 | 17 | 76736 | 1982 | 64419997 |
Localised oedema | 18.77 | 18.49 | 32 | 76721 | 7159 | 64414820 |
Body temperature decreased | 18.69 | 18.49 | 4 | 76749 | 25924 | 64396055 |
Chronic respiratory failure | 18.54 | 18.49 | 19 | 76734 | 2587 | 64419392 |
Pulmonary artery dilatation | 18.53 | 18.49 | 9 | 76744 | 364 | 64421615 |
None
Source | Code | Description |
---|---|---|
ATC | B01AC09 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Platelet aggregation inhibitors excl. heparin |
FDA CS | M0017817 | Prostaglandins I |
FDA PE | N0000009909 | Vasodilation |
FDA EPC | N0000175416 | Prostacycline Vasodilator |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D010975 | Platelet Aggregation Inhibitors |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pulmonary arterial hypertension | indication | 11399002 | |
Cough | indication | 49727002 | |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Rhinitis | indication | 70076002 | DOID:4483 |
Pulmonary hypertension | indication | 70995007 | DOID:6432 |
Common cold | indication | 82272006 | DOID:10459 |
Pulmonary edema | contraindication | 19242006 | DOID:11396 |
Chronic heart failure | contraindication | 48447003 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.75 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP1 subtype | GPCR | AGONIST | Ki | 4.80 | IUPHAR | IUPHAR | |||
Prostacyclin receptor | GPCR | AGONIST | Ki | 7.80 | IUPHAR | CHEMBL | |||
P2Y purinoceptor 12 | GPCR | WOMBAT-PK | |||||||
Prostaglandin E2 receptor EP4 subtype | GPCR | AGONIST | Ki | 5.10 | IUPHAR |
ID | Source |
---|---|
4024020 | VUID |
N0000022025 | NUI |
D00106 | KEGG_DRUG |
61849-14-7 | SECONDARY_CAS_RN |
4020958 | VANDF |
4024020 | VANDF |
C0033567 | UMLSCUI |
CHEBI:15552 | CHEBI |
CHEMBL1139 | ChEMBL_ID |
DB01240 | DRUGBANK_ID |
CHEMBL962 | ChEMBL_ID |
D011464 | MESH_DESCRIPTOR_UI |
5282411 | PUBCHEM_CID |
4725 | INN_ID |
DCR9Z582X0 | UNII |
104463 | RXNORM |
137029 | MMSL |
29551 | MMSL |
4669 | MMSL |
d03842 | MMSL |
003963 | NDDF |
003964 | NDDF |
108593000 | SNOMEDCT_US |
108594006 | SNOMEDCT_US |
372513003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
FLOLAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0517 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 0.50 mg | INTRAVENOUS | NDA | 25 sections |
FLOLAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0519 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1.50 mg | INTRAVENOUS | NDA | 25 sections |
Epoprostenol Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-1985 | INJECTION, POWDER, FOR SOLUTION | 0.50 mg | INTRAVENOUS | ANDA | 23 sections |
Epoprostenol Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-1995 | INJECTION, POWDER, FOR SOLUTION | 1.50 mg | INTRAVENOUS | ANDA | 23 sections |
epoprostenol | Human Prescription Drug Label | 1 | 62756-059 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 0.50 mg | INTRAVENOUS | ANDA | 25 sections |
epoprostenol | Human Prescription Drug Label | 1 | 62756-060 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1.50 mg | INTRAVENOUS | ANDA | 25 sections |
Veletri | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66215-402 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1.50 mg | INTRAVENOUS | NDA | 28 sections |
Veletri | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66215-403 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 0.50 mg | INTRAVENOUS | NDA | 28 sections |