ibuprofen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 1407 15687-27-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ibuprofen lysine
  • ibuprofen lysinate
  • ibuprofen lysine salt
  • soluphene
  • solufenum
  • neoprofen
  • ibuprofen
  • ibuprofen sodium
A nonsteroidal anti-inflammatory agent with analgesic properties used in the treatment of RHEUMATISM and ARTHRITIS. Concerns that anti-inflammatory drugs such as ibuprofen may worsen COVID-19 circulated widely in the early months of the pandemic. FDA has stated that it is not aware of scientific evidence connecting the use of NSAIAs, such as ibuprofen, with worsening COVID-19 symptoms and will communicate publicly when more information is available.
  • Molecular weight: 206.29
  • Formula: C13H18O2
  • CLOGP: 3.68
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -3.48
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg P
1.20 g O
1.20 g P
1.20 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 193.90 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 85 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.15 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.82 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 19, 1974 FDA
Jan. 19, 2018 PMDA Senju Pharmaceutical Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional overdose 899.40 9.84 1371 239172 63573 46381946
Cholecystitis chronic 566.25 9.84 454 240089 10045 46435474
Injury 501.81 9.84 851 239692 43176 46402343
Angioedema 466.41 9.84 774 239769 38568 46406951
Suicide attempt 313.86 9.84 800 239743 54236 46391283
Emotional distress 311.46 9.84 564 239979 30143 46415376
Drug hypersensitivity 290.82 9.84 2200 238343 241625 46203894
Death 269.91 9.84 860 239683 334688 46110831
Uterine perforation 225.03 9.84 230 240313 7037 46438482
Abdominal pain upper 223.35 9.84 1396 239147 143909 46301610
Overdose 219.89 9.84 1074 239469 100905 46344614
Tubulointerstitial nephritis 219.86 9.84 323 240220 14465 46431054
Deep vein thrombosis 208.32 9.84 889 239654 78884 46366635
Gallbladder disorder 202.93 9.84 341 240202 17157 46428362
Renal tubular acidosis 192.21 9.84 113 240430 1470 46444049
Off label use 186.47 9.84 1170 239373 378671 46066848
Aspirin-exacerbated respiratory disease 178.73 9.84 84 240459 664 46444855
Urticaria 178.20 9.84 1128 239415 116764 46328755
Toxicity to various agents 170.19 9.84 1753 238790 210013 46235506
Pneumonia 168.19 9.84 1192 239351 375128 46070391
Cholelithiasis 152.99 9.84 493 240050 38188 46407331
Deafness transitory 151.09 9.84 98 240445 1534 46443985
Biliary dyskinesia 149.68 9.84 120 240423 2653 46442866
Pain 148.67 9.84 3355 237188 473593 45971926
Haematemesis 142.16 9.84 397 240146 28409 46417110
Gastrointestinal pain 128.83 9.84 175 240368 7280 46438239
Completed suicide 126.80 9.84 1228 239315 144692 46300827
Pulmonary embolism 126.39 9.84 975 239568 107610 46337909
Gastric ulcer 123.72 9.84 317 240226 21546 46423973
Lip oedema 121.87 9.84 116 240427 3248 46442271
Cardiac failure congestive 116.23 9.84 183 240360 91567 46353952
Rheumatoid arthritis 114.51 9.84 746 239797 239469 46206050
Interstitial lung disease 112.91 9.84 69 240474 53880 46391639
Drug ineffective 111.87 9.84 2652 237891 675186 45770333
Acute kidney injury 111.86 9.84 1771 238772 234084 46211435
Cardiac failure 111.55 9.84 149 240394 79799 46365720
Kounis syndrome 105.96 9.84 70 240473 1132 46444387
Intentional self-injury 103.83 9.84 317 240226 23849 46421670
Muscle spasticity 103.33 9.84 200 240343 11240 46434279
Febrile neutropenia 100.83 9.84 210 240333 94417 46351102
Systemic lupus erythematosus 95.56 9.84 117 240426 65063 46380456
Pemphigus 94.61 9.84 58 240485 45216 46400303
Metabolic acidosis 93.42 9.84 422 240121 38358 46407161
Treatment failure 93.06 9.84 214 240329 92873 46352646
Plasma cell myeloma 92.92 9.84 57 240486 44421 46401098
Anxiety 90.67 9.84 1378 239165 180579 46264940
Atrial fibrillation 86.17 9.84 261 240282 103329 46342190
Vomiting 83.80 9.84 2982 237561 449812 45995707
Toxic epidermal necrolysis 81.87 9.84 277 240266 22001 46423518
Gallbladder injury 81.80 9.84 63 240480 1311 46444208
Fall 81.61 9.84 1199 239344 327898 46117621
Stevens-Johnson syndrome 79.81 9.84 283 240260 23014 46422505
Anhedonia 79.46 9.84 169 240374 10166 46435353
Hospitalisation 78.77 9.84 128 240415 63257 46382262
Peritonsillar abscess 78.42 9.84 43 240500 485 46445034
Meningitis aseptic 77.40 9.84 100 240443 3959 46441560
Neutropenia 73.72 9.84 434 240109 142770 46302749
Bezoar 73.61 9.84 60 240483 1359 46444160
Malignant neoplasm progression 71.78 9.84 141 240402 64785 46380734
Lip swelling 71.70 9.84 290 240253 25105 46420414
Upper gastrointestinal haemorrhage 71.37 9.84 219 240324 16519 46429000
Sepsis 71.19 9.84 410 240133 135604 46309915
Fluid overload 70.31 9.84 26 240517 27159 46418360
Ear pain 68.63 9.84 260 240283 21832 46423687
Pharyngitis 68.51 9.84 223 240320 17360 46428159
Melaena 65.98 9.84 301 240242 27471 46418048
Fixed eruption 65.83 9.84 46 240497 819 46444700
Ear infection 65.13 9.84 263 240280 22750 46422769
Gastritis 64.88 9.84 349 240194 34029 46411490
Eyelid oedema 64.73 9.84 156 240387 10201 46435318
Maternal exposure during pregnancy 64.51 9.84 290 240253 102259 46343260
Pruritus 63.71 9.84 1667 238876 240685 46204834
Muscle injury 63.43 9.84 100 240443 4766 46440753
Hypoaldosteronism 63.41 9.84 27 240516 164 46445355
Headache 63.16 9.84 3040 237503 475312 45970207
Wound closure 61.88 9.84 26 240517 152 46445367
Duodenal ulcer 61.33 9.84 123 240420 7095 46438424
Vanishing bile duct syndrome 61.23 9.84 40 240503 634 46444885
Gastrointestinal haemorrhage 60.79 9.84 638 239905 76735 46368784
Platelet count decreased 60.46 9.84 287 240256 99737 46345782
Self-medication 59.29 9.84 64 240479 2088 46443431
Abdominal pain 58.07 9.84 1574 238969 228457 46217062
Diarrhoea 57.92 9.84 2328 238215 557274 45888245
Alopecia 57.86 9.84 546 239997 161868 46283651
Gastric ulcer perforation 56.73 9.84 47 240496 1090 46444429
Disease progression 54.58 9.84 263 240280 91037 46354482
Osteotomy 53.63 9.84 27 240516 252 46445267
Biliary colic 52.85 9.84 77 240466 3421 46442098
Pelvic pain 52.48 9.84 155 240388 11447 46434072
Acute hepatic failure 51.43 9.84 180 240363 14541 46430978
Drug resistance 51.42 9.84 13 240530 17355 46428164
Gallbladder cholesterolosis 51.35 9.84 38 240505 743 46444776
Thrombocytopenia 51.07 9.84 412 240131 126169 46319350
Irritable bowel syndrome 51.00 9.84 194 240349 16321 46429198
Renal impairment 50.65 9.84 204 240339 74168 46371351
Pulmonary infarction 49.68 9.84 65 240478 2606 46442913
Shoulder arthroplasty 49.27 9.84 70 240473 3038 46442481
Cytomegalovirus infection 49.25 9.84 16 240527 18128 46427391
Ductus arteriosus premature closure 48.60 9.84 27 240516 313 46445206
Thrombophlebitis superficial 48.31 9.84 90 240453 4913 46440606
Pulmonary arterial hypertension 47.84 9.84 38 240505 25890 46419629
Analgesic drug level increased 47.56 9.84 48 240495 1446 46444073
Cholecystitis acute 46.53 9.84 113 240430 7425 46438094
Jejunal ulcer 45.96 9.84 18 240525 85 46445434
Fluid retention 45.81 9.84 124 240419 50922 46394597
Myocardial infarction 45.30 9.84 305 240238 97223 46348296
Embedded device 45.24 9.84 65 240478 2851 46442668
Bone marrow failure 44.81 9.84 52 240491 29617 46415902
Multiple sclerosis relapse 43.92 9.84 369 240174 41756 46403763
Chronic obstructive pulmonary disease 43.87 9.84 151 240392 57482 46388037
Enthesopathy 43.59 9.84 83 240460 4607 46440912
Drug intolerance 43.57 9.84 516 240027 146533 46298986
Femur fracture 42.95 9.84 78 240465 36919 46408600
Face oedema 42.85 9.84 204 240339 18949 46426570
Red blood cell sedimentation rate abnormal 42.83 9.84 9 240534 13640 46431879
Medical device discomfort 42.35 9.84 52 240491 1954 46443565
Anaemia 42.06 9.84 1000 239543 254779 46190740
Folliculitis 41.56 9.84 96 240447 6107 46439412
Hand deformity 40.94 9.84 72 240471 34502 46411017
Drug-induced liver injury 40.94 9.84 247 240296 25121 46420398
Night sweats 40.64 9.84 260 240283 26990 46418529
Body temperature increased 40.08 9.84 242 240301 24619 46420900
Cholesterosis 39.43 9.84 26 240517 419 46445100
Foot operation 39.39 9.84 80 240463 4657 46440862
Rheumatoid factor positive 39.01 9.84 29 240514 20432 46425087
Pelvic venous thrombosis 38.00 9.84 44 240499 1553 46443966
Acute myeloid leukaemia 37.70 9.84 17 240526 15761 46429758
Respiratory disorder 36.80 9.84 254 240289 27046 46418473
General physical health deterioration 36.29 9.84 816 239727 114953 46330566
Pleural effusion 36.27 9.84 264 240279 82688 46362831
Duodenal ulcer perforation 36.02 9.84 111 240432 8391 46437128
Wrong technique in product usage process 35.98 9.84 151 240392 54271 46391248
Foetal acidosis 35.86 9.84 10 240533 10 46445509
Glossodynia 35.32 9.84 114 240429 44259 46401260
Laryngeal oedema 35.28 9.84 82 240461 5237 46440282
Synovitis 34.73 9.84 179 240364 60896 46384623
Cardiac disorder 34.69 9.84 113 240430 43745 46401774
Cholecystitis 34.51 9.84 157 240386 14309 46431210
Neonatal cardiac failure 34.19 9.84 8 240535 0 46445519
Pneumocystis jirovecii pneumonia 34.05 9.84 18 240525 15230 46430289
Brain death 34.04 9.84 56 240487 2767 46442752
Abdominal pain lower 34.03 9.84 206 240337 20975 46424544
Clostridium difficile infection 33.77 9.84 48 240495 25055 46420464
Herpes zoster 33.68 9.84 208 240335 67664 46377855
Migraine 33.53 9.84 527 240016 69499 46376020
Pneumonia aspiration 32.92 9.84 71 240472 31534 46413985
Gastric perforation 32.89 9.84 37 240506 1265 46444254
Pancytopenia 32.86 9.84 280 240263 84778 46360741
Product prescribing error 32.86 9.84 196 240347 19851 46425668
Open globe injury 32.82 9.84 12 240531 45 46445474
Contraindicated product administered 32.79 9.84 259 240284 79688 46365831
Haemoglobin decreased 32.48 9.84 468 240075 128481 46317038
Acute generalised exanthematous pustulosis 31.99 9.84 114 240429 9291 46436228
Genital haemorrhage 31.90 9.84 90 240453 6476 46439043
Protein-losing gastroenteropathy 31.81 9.84 16 240527 149 46445370
Myelodysplastic syndrome 31.62 9.84 21 240522 15690 46429829
Procedural pain 31.42 9.84 143 240400 13036 46432483
Hyponatraemia 31.39 9.84 352 240191 100980 46344539
Pulmonary hypertension 31.13 9.84 89 240454 35904 46409615
Duodenal ulcer haemorrhage 30.72 9.84 49 240494 2359 46443160
Gallbladder hypofunction 30.70 9.84 24 240519 511 46445008
Medication overuse headache 30.68 9.84 23 240520 459 46445060
Malaise 30.36 9.84 1396 239147 329836 46115683
Respiratory failure 30.31 9.84 327 240216 94489 46351030
Oxygen saturation decreased 30.29 9.84 220 240323 68944 46376575
Multiple organ dysfunction syndrome 30.29 9.84 150 240393 51560 46393959
Hepatitis cholestatic 30.00 9.84 89 240454 6588 46438931
Premature delivery 29.89 9.84 42 240501 22027 46423492
Scar 29.84 9.84 132 240411 11887 46433632
Hypocalcaemia 29.74 9.84 58 240485 26727 46418792
Device related infection 29.55 9.84 39 240504 21002 46424517
Cholecystectomy 29.40 9.84 108 240435 8934 46436585
Medical device pain 29.34 9.84 38 240505 1508 46444011
Transfusion 28.99 9.84 16 240527 13215 46432304
Ankylosing spondylitis 28.58 9.84 88 240455 6649 46438870
Acute lung injury 28.55 9.84 34 240509 1237 46444282
Sleep disorder due to general medical condition, insomnia type 28.55 9.84 75 240468 5174 46440345
Corneal leukoma 28.20 9.84 8 240535 9 46445510
Nasal disorder 28.17 9.84 45 240498 2169 46443350
Neurotoxicity 28.06 9.84 18 240525 13699 46431820
Drug abuse 28.04 9.84 471 240072 62937 46382582
Infusion related reaction 27.75 9.84 361 240182 100847 46344672
Poisoning 27.72 9.84 144 240399 13850 46431669
Orthostatic hypotension 27.72 9.84 53 240490 24605 46420914
Tinnitus 27.58 9.84 240 240303 27433 46418086
Hypomagnesaemia 27.44 9.84 45 240498 22165 46423354
Brain empyema 27.43 9.84 7 240536 3 46445516
Hip fracture 27.38 9.84 60 240483 26496 46419023
Dysmenorrhoea 27.36 9.84 58 240485 3480 46442039
Urinary tract infection 27.24 9.84 896 239647 219370 46226149
Sinusitis 27.23 9.84 868 239675 128900 46316619
Tenosynovitis 27.22 9.84 93 240450 7422 46438097
Psychological trauma 27.16 9.84 31 240512 1077 46444442
Infected dermal cyst 27.02 9.84 21 240522 443 46445076
Duodenitis haemorrhagic 26.92 9.84 8 240535 12 46445507
Distichiasis 26.92 9.84 8 240535 12 46445507
Neutrophil count decreased 26.58 9.84 124 240419 43302 46402217
Neuropathy peripheral 26.50 9.84 320 240223 90573 46354946
Swelling face 26.42 9.84 402 240141 52657 46392862
Dementia 26.16 9.84 23 240520 14907 46430612
Osteoporosis 26.02 9.84 114 240429 40494 46405025
Fear 25.80 9.84 157 240386 16015 46429504
Depression 25.78 9.84 1097 239446 169007 46276512
Effusion 25.76 9.84 35 240508 1456 46444063
Genital odour 25.64 9.84 6 240537 0 46445519
White blood cell count decreased 25.64 9.84 415 240128 111816 46333703
Right ventricular failure 25.63 9.84 27 240516 16066 46429453
Toxic shock syndrome streptococcal 25.62 9.84 12 240531 94 46445425
Laryngeal discomfort 25.57 9.84 17 240526 278 46445241
Anaphylactic reaction 25.53 9.84 400 240143 52712 46392807
Genital tract inflammation 25.48 9.84 8 240535 16 46445503
Renal papillary necrosis 25.31 9.84 16 240527 239 46445280
Palatal oedema 25.24 9.84 21 240522 490 46445029
Pneumonia streptococcal 25.16 9.84 37 240506 1658 46443861
Peritonitis bacterial 24.63 9.84 7 240536 8646 46436873
Septic shock 24.46 9.84 186 240357 57707 46387812
Serum sickness-like reaction 24.32 9.84 19 240524 404 46445115
Leukopenia 24.20 9.84 230 240313 68113 46377406
Jaundice 24.14 9.84 241 240302 28604 46416915
Dyspnoea exertional 23.98 9.84 156 240387 50133 46395386
SJS-TEN overlap 23.91 9.84 13 240530 144 46445375
Gastritis erosive 23.91 9.84 71 240472 5259 46440260
Intentional product misuse 23.83 9.84 358 240185 46770 46398749
Product dose omission issue 23.64 9.84 674 239869 167846 46277673
Renal tubular necrosis 23.64 9.84 114 240429 10645 46434874
Hepatic necrosis 23.61 9.84 73 240470 5528 46439991
Hypertensive emergency 23.55 9.84 35 240508 1583 46443936
Food refusal 23.38 9.84 16 240527 275 46445244
Kidney enlargement 23.36 9.84 20 240523 486 46445033
Hepatitis acute 23.34 9.84 94 240449 8120 46437399
Back pain 23.33 9.84 1314 239229 208725 46236794
Hypoglycaemia 23.26 9.84 174 240369 54175 46391344
Hypothermia 23.20 9.84 124 240419 12059 46433460
Deafness 23.15 9.84 152 240391 15916 46429603
Functional gastrointestinal disorder 23.15 9.84 51 240492 3143 46442376
Cerebral venous sinus thrombosis 23.09 9.84 37 240506 1788 46443731
Necrosis ischaemic 23.05 9.84 25 240518 820 46444699
Bone erosion 22.84 9.84 10 240533 9433 46436086
Chondritis 22.63 9.84 7 240536 13 46445506
Fear of disease 22.56 9.84 28 240515 1064 46444455
Wound 22.38 9.84 129 240414 42673 46402846
Haematochezia 22.25 9.84 293 240250 37200 46408319
Abortion spontaneous 22.24 9.84 332 240211 43314 46402205
Internal injury 22.22 9.84 18 240525 404 46445115
Beta haemolytic streptococcal infection 22.15 9.84 37 240506 1852 46443667
Diabetes mellitus 22.04 9.84 159 240384 49906 46395613
Pharyngeal abscess 21.92 9.84 14 240529 213 46445306
Productive cough 21.87 9.84 162 240381 50553 46394966
Bradycardia 21.85 9.84 227 240316 66071 46379448
Anal haemorrhage 21.79 9.84 33 240510 1518 46444001
Device expulsion 21.75 9.84 71 240472 27471 46418048
Enzyme induction 21.65 9.84 9 240534 51 46445468
Pneumonia viral 21.56 9.84 4 240539 6620 46438899
Infertility female 21.48 9.84 21 240522 608 46444911
Bronchopulmonary aspergillosis 21.45 9.84 6 240537 7490 46438029
Influenza like illness 21.35 9.84 416 240127 57154 46388365
Dehydration 21.15 9.84 643 239900 158897 46286622
Nausea 21.15 9.84 3933 236610 683521 45761998
Red blood cell sedimentation rate 21.15 9.84 35 240508 1738 46443781
Chromaturia 20.99 9.84 141 240402 14878 46430641
Ascites 20.92 9.84 107 240436 36477 46409042
Coma scale abnormal 20.88 9.84 65 240478 4941 46440578
Knee arthroplasty 20.84 9.84 58 240485 23607 46421912
Ceruloplasmin decreased 20.60 9.84 6 240537 8 46445511
Tongue oedema 20.54 9.84 56 240487 3950 46441569
Tendonitis 20.54 9.84 135 240408 14142 46431377
Cardiac failure acute 20.43 9.84 8 240535 8070 46437449
Tumour lysis syndrome 20.32 9.84 6 240537 7230 46438289
Mediastinal abscess 20.19 9.84 6 240537 9 46445510
Skin papilloma 20.05 9.84 57 240486 4119 46441400
Dyspareunia 19.98 9.84 40 240503 2304 46443215
Dermo-hypodermitis 19.95 9.84 14 240529 251 46445268
Embolism arterial 19.64 9.84 27 240516 1136 46444383
Brain injury 19.61 9.84 73 240470 6077 46439442
Mucosal inflammation 19.56 9.84 119 240424 38857 46406662
Exposure during pregnancy 19.47 9.84 417 240126 107795 46337724
Swollen tongue 19.29 9.84 233 240310 28999 46416520
Product communication issue 19.29 9.84 12 240531 174 46445345
Tachycardia 19.26 9.84 660 239883 98962 46346557
Allergy test positive 19.20 9.84 15 240528 319 46445200
Paraesthesia 19.07 9.84 763 239780 116674 46328845
Pathogen resistance 19.01 9.84 4 240539 6056 46439463
Poisoning deliberate 18.89 9.84 86 240457 7840 46437679
Periorbital oedema 18.84 9.84 63 240480 4972 46440547
Suicidal ideation 18.79 9.84 401 240142 55981 46389538
Uterine leiomyoma 18.65 9.84 87 240456 8012 46437507
Ludwig angina 18.41 9.84 7 240536 30 46445489
Thyroid disorder 18.41 9.84 21 240522 12055 46433464
Erosive duodenitis 18.37 9.84 17 240526 459 46445060
Anion gap 18.25 9.84 25 240518 1048 46444471
Intestinal obstruction 18.08 9.84 71 240472 26004 46419515
Genital pain 18.07 9.84 14 240529 294 46445225
Therapeutic response decreased 18.05 9.84 139 240404 43006 46402513
Bronchiectasis 18.02 9.84 13 240530 9303 46436216
Blood magnesium decreased 18.01 9.84 18 240525 10974 46434545
Multiple sclerosis 17.87 9.84 201 240342 24590 46420929
Hepatic function abnormal 17.85 9.84 104 240439 34317 46411202
Tongue disorder 17.76 9.84 79 240464 7131 46438388
Bronchitis 17.75 9.84 413 240130 105566 46339953
Dactylitis 17.64 9.84 26 240517 1167 46444352
Epilepsy 17.52 9.84 63 240480 23675 46421844
Posterior reversible encephalopathy syndrome 17.50 9.84 32 240511 15109 46430410
No adverse event 17.45 9.84 104 240439 34127 46411392
Product use in unapproved indication 17.38 9.84 344 240199 89929 46355590
Accidental exposure to product by child 17.37 9.84 25 240518 1098 46444421
Autoimmune hepatitis 17.31 9.84 83 240460 7731 46437788
Thrombophlebitis septic 17.28 9.84 10 240533 126 46445393
Musculoskeletal disorder 17.18 9.84 138 240405 15407 46430112
Oesophageal discomfort 17.13 9.84 11 240532 169 46445350
Photophobia 17.11 9.84 131 240412 14413 46431106
Blister 17.06 9.84 324 240219 44307 46401212
Perichondritis 16.95 9.84 6 240537 20 46445499
Product use issue 16.94 9.84 365 240178 94279 46351240
Necrotising fasciitis 16.92 9.84 40 240503 2583 46442936
Lower respiratory tract infection 16.84 9.84 387 240156 54702 46390817
Trichiasis 16.84 9.84 8 240535 65 46445454
Acute haemorrhagic oedema of infancy 16.73 9.84 6 240537 21 46445498
Coma 16.64 9.84 406 240137 57943 46387576
Blood copper decreased 16.63 9.84 5 240538 8 46445511
Gastric ulcer haemorrhage 16.55 9.84 59 240484 4809 46440710
Intestinal diaphragm disease 16.53 9.84 9 240534 100 46445419
Psychogenic tremor 16.51 9.84 6 240537 22 46445497
Disturbance in attention 16.44 9.84 241 240302 31319 46414200
Pulmonary fibrosis 16.42 9.84 51 240492 20041 46425478
Hypertonia neonatal 16.37 9.84 12 240531 231 46445288
Acquired haemophilia 16.31 9.84 22 240521 909 46444610
Tremor neonatal 16.30 9.84 9 240534 103 46445416
Neonatal hypoxia 16.29 9.84 16 240527 466 46445053
Superior sagittal sinus thrombosis 16.14 9.84 21 240522 837 46444682
Serotonin syndrome 16.13 9.84 67 240476 24153 46421366
Cytokine release syndrome 16.01 9.84 6 240537 6217 46439302
Gastric infection 15.99 9.84 41 240502 2787 46442732
Evans syndrome 15.98 9.84 11 240532 191 46445328
Viral parotitis 15.93 9.84 5 240538 10 46445509
Second primary malignancy 15.88 9.84 7 240536 6577 46438942
Device issue 15.79 9.84 165 240378 19815 46425704
Pulseless electrical activity 15.79 9.84 76 240467 7091 46438428
Electrocardiogram U-wave abnormality 15.73 9.84 7 240536 48 46445471
Pregnancy with contraceptive device 15.68 9.84 55 240488 4448 46441071
Creatinine renal clearance abnormal 15.64 9.84 11 240532 198 46445321
Hyperlactacidaemia 15.64 9.84 35 240508 2180 46443339
Dyspnoea 15.62 9.84 2375 238168 513173 45932346
Alpha 1 microglobulin increased 15.61 9.84 5 240538 11 46445508
Aspergillus infection 15.58 9.84 8 240535 6882 46438637
Liver disorder 15.58 9.84 120 240423 37126 46408393
Thrombotic microangiopathy 15.54 9.84 12 240531 8294 46437225
Abscess rupture 15.45 9.84 11 240532 202 46445317
Dyspepsia 15.41 9.84 462 240081 68010 46377509
Acute pulmonary oedema 15.28 9.84 11 240532 7880 46437639
Metastases to bone 15.27 9.84 43 240500 17433 46428086
Unevaluable event 15.25 9.84 158 240385 46017 46399502
Staphylococcal sepsis 15.25 9.84 10 240533 7522 46437997
Optic neuritis 15.24 9.84 73 240470 6798 46438721
Coagulopathy 15.21 9.84 154 240389 18345 46427174
Vulval disorder 15.16 9.84 18 240525 653 46444866
Lung neoplasm malignant 15.15 9.84 36 240507 15453 46430066
Skin discomfort 15.06 9.84 14 240529 380 46445139
Gastrointestinal sounds abnormal 15.06 9.84 46 240497 3460 46442059
Osteonecrosis 14.89 9.84 75 240468 25669 46419850
Salivary gland cyst 14.87 9.84 4 240539 3 46445516
Duodenal ulcer repair 14.82 9.84 7 240536 56 46445463
Device malfunction 14.81 9.84 29 240514 13345 46432174
Gastrointestinal disorder 14.80 9.84 407 240136 59169 46386350
Allergic respiratory disease 14.73 9.84 6 240537 32 46445487
Drug level decreased 14.71 9.84 6 240537 5906 46439613
Mydriasis 14.70 9.84 99 240444 10454 46435065
Cephalo-pelvic disproportion 14.65 9.84 11 240532 220 46445299
Lip erythema 14.61 9.84 8 240535 90 46445429
Hepatic infiltration eosinophilic 14.58 9.84 6 240537 33 46445486
Cerebral haemorrhage 14.56 9.84 86 240457 28285 46417234
Cough 14.53 9.84 1006 239537 229243 46216276
Substance abuser 14.51 9.84 5 240538 15 46445504
Muscle rigidity 14.47 9.84 18 240525 9943 46435576
Cerebrovascular accident 14.44 9.84 403 240140 100636 46344883
Oedema peripheral 14.41 9.84 674 239869 159032 46286487
Limbal stem cell deficiency 14.34 9.84 4 240539 4 46445515
Chest wall abscess 14.29 9.84 6 240537 35 46445484
Device difficult to use 14.25 9.84 80 240463 7924 46437595
Benzodiazepine drug level increased 14.22 9.84 10 240533 180 46445339
Hyperchromic anaemia 14.15 9.84 6 240537 36 46445483
Schizophrenia 14.07 9.84 14 240529 8554 46436965
Intestinal cyst 14.02 9.84 8 240535 98 46445421
Alanine aminotransferase increased 13.97 9.84 573 239970 87878 46357641
Muscle tone disorder 13.95 9.84 8 240535 99 46445420
Nuchal rigidity 13.93 9.84 16 240527 560 46444959
Upper gastrointestinal perforation 13.88 9.84 4 240539 5 46445514
Throat tightness 13.83 9.84 165 240378 20474 46425045
Bacteraemia 13.83 9.84 33 240510 14146 46431373
Posthaemorrhagic hydrocephalus 13.83 9.84 5 240538 18 46445501
Metastases to liver 13.79 9.84 53 240490 19532 46425987
Pancreatitis acute 13.78 9.84 192 240351 24680 46420839
Underdose 13.72 9.84 53 240490 19505 46426014
Aplasia pure red cell 13.72 9.84 3 240540 4422 46441097
Diabetic ketoacidosis 13.66 9.84 48 240495 18162 46427357
Anti-thyroid antibody positive 13.62 9.84 14 240529 431 46445088
Henoch-Schonlein purpura nephritis 13.62 9.84 5 240538 19 46445500
Pulmonary valve disease 13.62 9.84 5 240538 19 46445500
Papillitis 13.62 9.84 5 240538 19 46445500
Cytopenia 13.57 9.84 12 240531 7756 46437763
Lung disorder 13.57 9.84 150 240393 43154 46402365
Pituitary tumour benign 13.52 9.84 28 240515 1653 46443866
Granuloma skin 13.51 9.84 44 240499 3426 46442093
Ductus arteriosus stenosis foetal 13.48 9.84 8 240535 106 46445413
Faeces discoloured 13.44 9.84 139 240404 16648 46428871
Staphylococcal scalded skin syndrome 13.44 9.84 9 240534 149 46445370
Abnormal clotting factor 13.42 9.84 8 240535 107 46445412
Left ventricular dysfunction 13.41 9.84 20 240523 10235 46435284
Labelled drug-food interaction medication error 13.38 9.84 6 240537 42 46445477
Breast cancer 13.35 9.84 160 240383 45358 46400161
Acidosis 13.35 9.84 101 240442 11073 46434446
Flank pain 13.30 9.84 106 240437 11807 46433712
Coronavirus infection 13.28 9.84 38 240505 2756 46442763
Diffuse large B-cell lymphoma 13.27 9.84 7 240536 5931 46439588
Pain in jaw 13.21 9.84 130 240413 38242 46407277
Device dislocation 13.19 9.84 171 240372 21631 46423888
Anoxia 13.17 9.84 11 240532 258 46445261
Systolic dysfunction 13.14 9.84 24 240519 1290 46444229
Progressive multifocal leukoencephalopathy 13.10 9.84 24 240519 11322 46434197
Bladder irritation 12.94 9.84 9 240534 159 46445360
Narrow anterior chamber angle 12.92 9.84 6 240537 46 46445473
Torsade de pointes 12.91 9.84 27 240516 12127 46433392
Autoimmune thyroiditis 12.91 9.84 39 240504 2916 46442603
Electrocardiogram QRS complex prolonged 12.89 9.84 59 240484 5390 46440129
Extrapyramidal disorder 12.86 9.84 24 240519 11244 46434275
Laryngeal web 12.82 9.84 3 240540 0 46445519
Uraemic gastropathy 12.82 9.84 3 240540 0 46445519
Anastomotic ulcer perforation 12.82 9.84 3 240540 0 46445519
Ultrasound antenatal screen 12.82 9.84 3 240540 0 46445519
Foetal non-stress test 12.82 9.84 3 240540 0 46445519
Xanthoma 12.81 9.84 6 240537 47 46445472
Grief reaction 12.79 9.84 10 240533 213 46445306
Base excess 12.70 9.84 5 240538 24 46445495
Diabetes mellitus inadequate control 12.70 9.84 31 240512 13183 46432336
Substance dependence 12.67 9.84 10 240533 216 46445303
Hyperacusis 12.65 9.84 29 240514 1835 46443684
Complication of device removal 12.47 9.84 43 240500 3447 46442072
Cataract 12.44 9.84 162 240381 45253 46400266
Biliary sepsis 12.42 9.84 15 240528 554 46444965
Blood pressure systolic increased 12.39 9.84 92 240451 28695 46416824
Vulvovaginitis trichomonal 12.38 9.84 5 240538 26 46445493
Strawberry tongue 12.38 9.84 5 240538 26 46445493
Platelet aggregation decreased 12.38 9.84 5 240538 26 46445493
Blood parathyroid hormone decreased 12.34 9.84 50 240493 4331 46441188
Facial spasm 12.30 9.84 16 240527 638 46444881
Pain in extremity 12.25 9.84 1517 239026 257163 46188356
Duodenitis 12.22 9.84 41 240502 3242 46442277
Product administration error 12.18 9.84 155 240388 19526 46425993
Blood pressure increased 12.14 9.84 531 240012 126135 46319384
Hangover 12.14 9.84 23 240520 1272 46444247
Anti-transglutaminase antibody 12.13 9.84 4 240539 10 46445509
Duodenogastric reflux 12.10 9.84 6 240537 54 46445465
Osteonecrosis of jaw 12.08 9.84 116 240427 34286 46411233
Glomerulonephropathy 12.04 9.84 7 240536 89 46445430
Circulatory collapse 12.01 9.84 167 240376 21457 46424062
Post cholecystectomy syndrome 12.01 9.84 6 240537 55 46445464
COVID-19 11.99 9.84 52 240491 18523 46426996
Injection site hyperaesthesia 11.93 9.84 5 240538 29 46445490
Parkinsonism 11.93 9.84 14 240529 7934 46437585
Glaucoma 11.92 9.84 42 240501 15879 46429640
Polymenorrhagia 11.92 9.84 6 240537 56 46445463
Frequent bowel movements 11.85 9.84 30 240513 12602 46432917
Spinal compression fracture 11.83 9.84 31 240512 12872 46432647
Oedema genital 11.82 9.84 9 240534 184 46445335
Glomerulonephritis minimal lesion 11.82 9.84 9 240534 184 46445335
Live birth 11.79 9.84 22 240521 10308 46435211
Cushingoid 11.79 9.84 9 240534 6257 46439262
Vertebral artery occlusion 11.78 9.84 7 240536 93 46445426
Dyskinesia 11.72 9.84 94 240449 28831 46416688
Gastric haemorrhage 11.71 9.84 61 240482 5873 46439646
Muscle tightness 11.67 9.84 92 240451 10213 46435306
Tuberculosis 11.59 9.84 22 240521 10243 46435276
Mental disorder 11.59 9.84 171 240372 22254 46423265
Full blood count decreased 11.58 9.84 67 240476 22144 46423375
Staphylococcal infection 11.57 9.84 123 240420 35648 46409871
Panniculitis 11.51 9.84 59 240484 5645 46439874
Quadriparesis 11.49 9.84 27 240516 1737 46443782
Vulval ulceration 11.34 9.84 9 240534 196 46445323
Hypogammaglobulinaemia 11.31 9.84 7 240536 5431 46440088
Substance abuse 11.30 9.84 47 240496 4120 46441399
Injection site extravasation 11.24 9.84 11 240532 6774 46438745
Ulcer 11.20 9.84 138 240405 17254 46428265
Fatigue 11.16 9.84 2877 237666 605820 45839699
Patient uncooperative 11.14 9.84 8 240535 149 46445370
Gastrointestinal ulcer 11.10 9.84 29 240514 1994 46443525
Drug withdrawal headache 11.07 9.84 6 240537 66 46445453
Poor venous access 11.06 9.84 16 240527 8292 46437227
Acute myocardial infarction 11.06 9.84 108 240435 31816 46413703
Oedema 11.05 9.84 262 240281 66809 46378710
Scleroderma 11.04 9.84 5 240538 4624 46440895
Red blood cell count decreased 11.03 9.84 111 240432 32512 46413007
Cardiotoxicity 11.02 9.84 11 240532 6711 46438808
Congestive cardiomyopathy 11.01 9.84 8 240535 5705 46439814
Pulmonary oedema 11.00 9.84 191 240352 50914 46394605
Superficial vein prominence 10.99 9.84 6 240537 67 46445452
Treatment noncompliance 10.98 9.84 99 240444 29632 46415887
Hepatobiliary scan abnormal 10.92 9.84 6 240537 68 46445451
Alveolar rhabdomyosarcoma 10.92 9.84 5 240538 37 46445482
Hip arthroplasty 10.91 9.84 52 240491 18060 46427459
Mania 10.78 9.84 25 240518 10821 46434698
Anion gap abnormal 10.77 9.84 11 240532 336 46445183
Oral candidiasis 10.76 9.84 50 240493 17482 46428037
Pharyngeal lesion 10.76 9.84 3 240540 3 46445516
Myoglobin urine 10.74 9.84 4 240539 16 46445503
Hunger 10.74 9.84 44 240499 3831 46441688
Thyroid stimulating immunoglobulin increased 10.66 9.84 7 240536 112 46445407
Musculoskeletal stiffness 10.66 9.84 612 239931 97381 46348138
Myoclonus 10.65 9.84 38 240505 14314 46431205
Peripheral sensory neuropathy 10.60 9.84 11 240532 6592 46438927
Disease recurrence 10.57 9.84 54 240489 18417 46427102
Tardive dyskinesia 10.57 9.84 14 240529 7529 46437990
Rales 10.57 9.84 21 240522 9610 46435909
Gait deviation 10.55 9.84 6 240537 73 46445446
Renal infarct 10.53 9.84 21 240522 1206 46444313
Hepatic enzyme increased 10.49 9.84 331 240212 81456 46364063
Macular degeneration 10.48 9.84 13 240530 7192 46438327
Adverse event 10.48 9.84 119 240424 34065 46411454
Hyperventilation 10.43 9.84 57 240486 5590 46439929
Mallory-Weiss syndrome 10.40 9.84 24 240519 1526 46443993
Colon cancer 10.35 9.84 20 240523 9249 46436270
Pericardial effusion 10.35 9.84 83 240460 25460 46420059
Blood glucose increased 10.34 9.84 287 240256 71726 46373793
Product administered to patient of inappropriate age 10.33 9.84 34 240509 2662 46442857
Transverse sinus thrombosis 10.32 9.84 15 240528 665 46444854
Tendon disorder 10.31 9.84 52 240491 4943 46440576
Heart rate decreased 10.29 9.84 109 240434 31614 46413905
Pneumoperitoneum 10.21 9.84 23 240520 1439 46444080
Reaction to excipient 10.21 9.84 20 240523 1134 46444385
Uterine pain 10.20 9.84 9 240534 228 46445291
Scleral oedema 10.20 9.84 4 240539 19 46445500
Carotid artery dissection 10.17 9.84 8 240535 172 46445347
Myelosuppression 10.10 9.84 15 240528 7688 46437831
Neck pain 10.08 9.84 364 240179 54942 46390577
Genitourinary symptom 10.08 9.84 6 240537 80 46445439
Persistent foetal circulation 10.07 9.84 9 240534 232 46445287
Myopathy 10.06 9.84 19 240524 8862 46436657
Eye disorder 10.04 9.84 140 240403 18001 46427518
Forced expiratory volume decreased 10.03 9.84 7 240536 5097 46440422
Medical diet 10.03 9.84 4 240539 20 46445499
Fat intolerance 10.03 9.84 4 240539 20 46445499
Human papilloma virus test positive 9.99 9.84 11 240532 367 46445152
Accident at home 9.95 9.84 7 240536 126 46445393
Amyotrophy 9.91 9.84 7 240536 127 46445392
Myeloma cast nephropathy 9.91 9.84 7 240536 127 46445392
Respiratory tract oedema 9.90 9.84 11 240532 371 46445148
Urosepsis 9.90 9.84 43 240500 15310 46430209
Time perception altered 9.87 9.84 4 240539 21 46445498
Lymphadenopathy 9.85 9.84 234 240309 33254 46412265
Product used for unknown indication 9.84 9.84 13 240530 526 46444993

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 498.61 10.07 666 124881 33718 29793213
Intentional overdose 389.87 10.07 656 124891 40825 29786106
Drug hypersensitivity 338.15 10.07 829 124718 67690 29759241
Suicide attempt 291.29 10.07 539 125008 36158 29790773
Haematemesis 280.91 10.07 440 125107 25763 29801168
Death 220.86 10.07 765 124782 356518 29470413
Melaena 215.43 10.07 442 125105 31995 29794936
Urticaria 214.47 10.07 607 124940 53999 29772932
Gastric haemorrhage 203.51 10.07 224 125323 9243 29817688
Aspirin-exacerbated respiratory disease 202.63 10.07 71 125476 296 29826635
Gastric ulcer 174.79 10.07 263 125284 14858 29812073
Lip oedema 165.36 10.07 108 125439 2129 29824802
Febrile neutropenia 163.28 10.07 125 125422 106568 29720363
Pneumonia 150.37 10.07 807 124740 333499 29493432
Duodenal ulcer 142.16 10.07 191 125356 9710 29817221
Completed suicide 138.13 10.07 799 124748 98693 29728238
Upper gastrointestinal haemorrhage 136.69 10.07 292 125255 21736 29805195
Anaphylactic reaction 134.06 10.07 335 125212 27647 29799284
Acute kidney injury 131.85 10.07 1737 123810 272105 29554826
Interstitial lung disease 131.65 10.07 44 125503 60153 29766778
Gastrointestinal haemorrhage 120.29 10.07 677 124870 82769 29744162
Tubulointerstitial nephritis 116.62 10.07 242 125305 17649 29809282
Gastritis 116.51 10.07 260 125287 19938 29806993
Overdose 114.23 10.07 673 124874 83664 29743267
Glomerulonephritis minimal lesion 113.11 10.07 48 125499 366 29826565
Off label use 112.29 10.07 601 124946 248689 29578242
Palatal oedema 109.91 10.07 57 125490 713 29826218
Neutropenia 105.87 10.07 239 125308 128301 29698630
Platelet count decreased 104.09 10.07 178 125369 105951 29720980
Duodenal ulcer haemorrhage 102.93 10.07 112 125435 4560 29822371
Gastric ulcer perforation 102.39 10.07 57 125490 829 29826102
Peptic ulcer 101.93 10.07 88 125459 2680 29824251
Duodenal ulcer perforation 95.09 10.07 69 125478 1623 29825308
Renal papillary necrosis 93.77 10.07 32 125515 121 29826810
Cardiac failure 89.25 10.07 132 125415 83286 29743645
Meningitis aseptic 87.90 10.07 75 125472 2247 29824684
Gastric ulcer haemorrhage 78.56 10.07 104 125443 5210 29821721
Metabolic acidosis 78.29 10.07 338 125209 37123 29789808
Peritonsillar abscess 77.67 10.07 34 125513 282 29826649
Sepsis 77.39 10.07 333 125214 146062 29680869
Cardiac failure congestive 76.98 10.07 148 125399 84259 29742672
Toxicity to various agents 73.31 10.07 1095 124452 176088 29650843
Face oedema 72.33 10.07 152 125395 11182 29815749
Abdominal pain upper 69.64 10.07 475 125072 62076 29764855
Stevens-Johnson syndrome 68.68 10.07 195 125352 17361 29809570
Enthesopathy 68.13 10.07 72 125475 2834 29824097
Headache 67.18 10.07 1105 124442 181201 29645730
Self-medication 66.94 10.07 64 125483 2230 29824701
Wound closure 66.51 10.07 24 125523 111 29826820
Eyelid oedema 65.91 10.07 93 125454 4952 29821979
Renal tubular acidosis 65.22 10.07 57 125490 1765 29825166
Ankylosing spondylitis 64.37 10.07 87 125460 4447 29822484
Osteotomy 64.36 10.07 24 125523 124 29826807
Pancytopenia 63.76 10.07 166 125381 84886 29742045
Cytomegalovirus infection 61.91 10.07 12 125535 23662 29803269
Gastritis erosive 61.14 10.07 95 125452 5518 29821413
Intestinal diaphragm disease 60.86 10.07 27 125520 232 29826699
Plasma cell myeloma 59.73 10.07 82 125465 53380 29773551
Hepatic function abnormal 55.80 10.07 56 125491 41889 29785042
Thrombocytopenia 55.29 10.07 342 125205 136702 29690229
Tongue oedema 54.98 10.07 63 125484 2717 29824214
Psoriatic arthropathy 54.91 10.07 168 125379 15593 29811338
Tenosynovitis 53.83 10.07 70 125477 3445 29823486
Faeces discoloured 53.67 10.07 154 125393 13792 29813139
Hypersensitivity 53.57 10.07 399 125148 53629 29773302
Disease progression 52.46 10.07 166 125381 79708 29747223
Drug resistance 51.00 10.07 11 125536 20122 29806809
Septic shock 50.90 10.07 120 125427 63487 29763444
Pyloric stenosis 50.25 10.07 31 125516 551 29826380
Swelling face 49.53 10.07 198 125349 21006 29805925
Pain 49.05 10.07 1005 124542 171636 29655295
Toxic epidermal necrolysis 48.90 10.07 176 125371 17764 29809167
Neutrophil count decreased 48.55 10.07 64 125483 42390 29784541
Tongue disorder 48.27 10.07 74 125473 4248 29822683
Nasal obstruction 48.16 10.07 32 125515 650 29826281
Tendonitis 46.95 10.07 104 125443 7932 29818999
Malignant neoplasm progression 45.54 10.07 153 125394 72134 29754797
Atrial fibrillation 45.08 10.07 267 125280 107857 29719074
Laryngeal dyspnoea 44.73 10.07 15 125532 53 29826878
Vomiting 43.95 10.07 1219 124328 218599 29608332
Hospitalisation 43.70 10.07 74 125473 44245 29782686
Lip swelling 43.61 10.07 135 125412 12609 29814322
White blood cell count decreased 43.06 10.07 193 125354 83754 29743177
Jejunal ulcer perforation 42.72 10.07 15 125532 63 29826868
Coronavirus infection 42.07 10.07 62 125485 3436 29823495
Macrocephaly 41.96 10.07 23 125524 324 29826607
Pruritus 39.65 10.07 706 124841 117498 29709433
Duodenitis 39.37 10.07 65 125482 3975 29822956
Bone marrow failure 39.35 10.07 40 125507 29745 29797186
Mast cell activation syndrome 38.24 10.07 15 125532 91 29826840
Intentional product misuse 37.81 10.07 262 125285 34405 29792526
Ascites 37.27 10.07 58 125489 35863 29791068
Tropical infectious disease 37.26 10.07 12 125535 36 29826895
Myocardial infarction 36.67 10.07 343 125204 125282 29701649
Conjunctivitis 36.44 10.07 94 125453 7906 29819025
Peritonitis bacterial 36.40 10.07 3 125544 11375 29815556
Acute hepatic failure 34.80 10.07 119 125428 11708 29815223
Encephalopathy 34.38 10.07 51 125496 32154 29794777
Hypoxia 33.15 10.07 97 125450 47757 29779174
Renal tubular necrosis 32.92 10.07 139 125408 15112 29811819
Synovitis 32.89 10.07 103 125444 9680 29817251
Erosive oesophagitis 32.74 10.07 35 125512 1396 29825535
Hypoglycaemia 32.72 10.07 107 125440 50874 29776057
Eye swelling 32.58 10.07 97 125450 8867 29818064
Gastritis haemorrhagic 32.56 10.07 32 125515 1154 29825777
Erythema multiforme 32.51 10.07 90 125457 7895 29819036
Myelodysplastic syndrome 31.32 10.07 20 125527 18758 29808173
C-reactive protein abnormal 31.13 10.07 71 125476 5522 29821409
Ventricular tachyarrhythmia 31.11 10.07 18 125529 283 29826648
Hyperhidrosis 30.99 10.07 423 125124 66667 29760264
Analgesic drug level increased 30.80 10.07 23 125524 566 29826365
Intervertebral disc protrusion 30.60 10.07 97 125450 9174 29817757
Weight increased 30.15 10.07 187 125360 74726 29752205
Multiple sclerosis relapse 29.97 10.07 107 125440 10755 29816176
Muscle swelling 29.93 10.07 19 125528 356 29826575
Perforated ulcer 29.90 10.07 14 125533 138 29826793
Dermatomyositis 29.85 10.07 29 125518 1031 29825900
Glomerulonephritis membranous 29.69 10.07 29 125518 1038 29825893
Joint swelling 29.57 10.07 314 125233 46632 29780299
Alanine aminotransferase abnormal 29.47 10.07 45 125502 2574 29824357
Helicobacter test positive 29.34 10.07 21 125526 483 29826448
Graft versus host disease 29.09 10.07 4 125543 10146 29816785
Brain empyema 28.87 10.07 7 125540 3 29826928
Pharyngeal abscess 28.56 10.07 20 125527 444 29826487
Dactylitis 28.40 10.07 20 125527 448 29826483
Pulmonary arterial hypertension 28.30 10.07 3 125544 9298 29817633
Meningitis pneumococcal 28.22 10.07 13 125534 123 29826808
Respiratory failure 28.00 10.07 278 125269 100364 29726567
Cerebral infarction 27.92 10.07 42 125505 26331 29800600
Neuropathy peripheral 27.80 10.07 177 125370 70298 29756633
Confusional state 27.71 10.07 398 125149 134436 29692495
Musculoskeletal stiffness 27.48 10.07 250 125297 35631 29791300
Nasal disorder 27.43 10.07 29 125518 1142 29825789
Tonsillitis 27.42 10.07 38 125509 1989 29824942
Arthralgia 27.34 10.07 754 124793 135037 29691894
Blood glucose increased 27.20 10.07 149 125398 61381 29765550
Fixed eruption 27.16 10.07 29 125518 1155 29825776
Hepatocellular carcinoma 27.05 10.07 4 125543 9606 29817325
Obstruction gastric 27.05 10.07 26 125521 912 29826019
Erysipelas 26.94 10.07 59 125488 4465 29822466
Lemierre syndrome 26.53 10.07 7 125540 7 29826924
Swelling of eyelid 26.52 10.07 17 125530 324 29826607
Beta haemolytic streptococcal infection 26.48 10.07 20 125527 501 29826430
Angular cheilitis 26.38 10.07 12 125535 110 29826821
Poisoning 26.35 10.07 106 125441 11276 29815655
Pneumocystis jirovecii pneumonia 26.22 10.07 20 125527 17100 29809831
Chronic obstructive pulmonary disease 26.15 10.07 102 125445 46024 29780907
Milk-alkali syndrome 25.88 10.07 20 125527 519 29826412
Back pain 25.78 10.07 587 124960 102009 29724922
Transposition of the great vessels 25.26 10.07 19 125528 473 29826458
Oral pruritus 25.21 10.07 15 125532 249 29826682
Flank pain 24.81 10.07 68 125479 5930 29821001
Symmetrical drug-related intertriginous and flexural exanthema 24.76 10.07 13 125534 167 29826764
Hypomagnesaemia 24.65 10.07 20 125527 16578 29810353
Superinfection 24.49 10.07 32 125515 1582 29825349
Discoloured vomit 24.45 10.07 17 125530 373 29826558
Hypoaldosteronism 24.43 10.07 13 125534 172 29826759
Diarrhoea 24.31 10.07 1149 124398 332954 29493977
Phonophobia 24.26 10.07 11 125536 100 29826831
Acute generalised exanthematous pustulosis 24.10 10.07 68 125479 6030 29820901
Tobacco abuse 23.98 10.07 17 125530 385 29826546
Medication overuse headache 23.90 10.07 9 125538 48 29826883
Pulmonary oedema 23.82 10.07 99 125448 43876 29783055
Pneumonia aspiration 23.76 10.07 80 125467 37700 29789231
Necrotising soft tissue infection 23.75 10.07 9 125538 49 29826882
Febrile bone marrow aplasia 23.67 10.07 3 125544 8094 29818837
Bronchopulmonary aspergillosis 23.52 10.07 11 125536 12273 29814658
Clostridium difficile infection 23.46 10.07 19 125528 15764 29811167
Drug-induced liver injury 23.32 10.07 161 125386 21113 29805818
Dermo-hypodermitis 23.17 10.07 15 125532 291 29826640
Gastrointestinal injury 23.05 10.07 16 125531 350 29826581
Haematochezia 23.02 10.07 232 125315 33990 29792941
Periorbital oedema 22.86 10.07 46 125501 3280 29823651
Hypotension 22.85 10.07 653 124894 199912 29627019
Infection masked 22.80 10.07 7 125540 17 29826914
Cardiac arrest 22.79 10.07 264 125283 92586 29734345
Fluid retention 22.62 10.07 44 125503 24954 29801977
Benign familial pemphigus 22.39 10.07 5 125542 0 29826931
Kawasaki's disease 22.39 10.07 5 125542 0 29826931
Prepyloric stenosis 22.39 10.07 5 125542 0 29826931
Macrophages increased 22.34 10.07 12 125535 162 29826769
Otitis media acute 22.02 10.07 16 125531 377 29826554
Fluid overload 21.60 10.07 29 125518 19063 29807868
Lymphocyte count decreased 21.50 10.07 29 125518 19026 29807905
Transplant rejection 21.43 10.07 6 125541 9200 29817731
Streptococcal infection 21.11 10.07 55 125492 4653 29822278
Cerebral atrophy congenital 20.75 10.07 8 125539 46 29826885
Duodenal obstruction 20.40 10.07 10 125537 110 29826821
Anaemia 20.33 10.07 691 124856 207301 29619630
Neuroleptic malignant syndrome 20.28 10.07 23 125524 16272 29810659
Wrong technique in product usage process 20.26 10.07 65 125482 31090 29795841
Cytopenia 19.94 10.07 5 125542 8251 29818680
Poisoning deliberate 19.70 10.07 62 125485 5842 29821089
Ulcer 19.69 10.07 68 125479 6723 29820208
Renal impairment 19.64 10.07 242 125305 83942 29742989
Gastrointestinal hypermotility 19.64 10.07 10 125537 120 29826811
Severe acute respiratory syndrome 19.42 10.07 6 125541 15 29826916
Kidney transplant rejection 19.23 10.07 4 125543 7505 29819426
Red blood cell count decreased 19.23 10.07 52 125495 26269 29800662
Peptic ulcer perforation 19.17 10.07 11 125536 170 29826761
Intestinal obstruction 19.01 10.07 32 125515 19180 29807751
Influenza like illness 18.90 10.07 177 125370 25428 29801503
Atrioventricular block complete 18.86 10.07 6 125541 8471 29818460
Conjunctival hyperaemia 18.85 10.07 34 125513 2233 29824698
Crying 18.80 10.07 59 125488 5550 29821381
Conjunctival scar 18.74 10.07 8 125539 62 29826869
Onychomycosis 18.70 10.07 33 125514 2130 29824801
Blood count abnormal 18.64 10.07 13 125534 11639 29815292
Pathogen resistance 18.63 10.07 6 125541 8404 29818527
Meningitis streptococcal 18.49 10.07 7 125540 38 29826893
Diffuse large B-cell lymphoma 18.45 10.07 5 125542 7836 29819095
Erosive duodenitis 18.39 10.07 26 125521 1387 29825544
Vanishing bile duct syndrome 18.30 10.07 18 125529 650 29826281
Intentional self-injury 18.28 10.07 108 125439 13424 29813507
Food intolerance 18.26 10.07 23 125524 1096 29825835
Coma 18.25 10.07 254 125293 40195 29786736
Intervertebral disc disorder 18.19 10.07 29 125518 1722 29825209
Oropharyngeal blistering 18.16 10.07 11 125536 189 29826742
Mucosal necrosis 18.11 10.07 8 125539 68 29826863
Implant site extravasation 18.02 10.07 15 125532 434 29826497
Tympanic membrane hyperaemia 17.92 10.07 4 125543 0 29826931
Acute myeloid leukaemia 17.80 10.07 30 125517 17976 29808955
Delirium 17.62 10.07 99 125448 40532 29786399
Drug ineffective 17.56 10.07 1210 124337 339177 29487754
Epistaxis 17.51 10.07 140 125407 52841 29774090
Mallory-Weiss syndrome 17.44 10.07 25 125522 1351 29825580
Energy increased 17.38 10.07 24 125523 1252 29825679
Tumour lysis syndrome 17.36 10.07 17 125530 12868 29814063
Duodenal stenosis 17.33 10.07 11 125536 206 29826725
Skin texture abnormal 17.32 10.07 6 125541 24 29826907
Transmission of an infectious agent via product 17.24 10.07 10 125537 158 29826773
Hepatitis acute 17.23 10.07 67 125480 7016 29819915
Cerebral haemorrhage 17.21 10.07 75 125472 32812 29794119
Ocular icterus 17.17 10.07 39 125508 3025 29823906
Ankle deformity 17.10 10.07 11 125536 211 29826720
Alcohol use 16.98 10.07 44 125503 3711 29823220
Herbal interaction 16.96 10.07 13 125534 333 29826598
Aortic bruit 16.81 10.07 10 125537 166 29826765
Xyphoid retraction 16.81 10.07 10 125537 166 29826765
Nasal septum deviation 16.78 10.07 20 125527 900 29826031
Thrombosis mesenteric vessel 16.76 10.07 7 125540 51 29826880
Oesophagitis haemorrhagic 16.70 10.07 11 125536 220 29826711
Paraesthesia oral 16.66 10.07 43 125504 3618 29823313
Dyspepsia 16.44 10.07 197 125350 30132 29796799
Epiglottic oedema 16.35 10.07 10 125537 175 29826756
Acquired epidermolysis bullosa 16.33 10.07 5 125542 12 29826919
Portal vein phlebitis 16.33 10.07 5 125542 12 29826919
International normalised ratio increased 16.31 10.07 125 125422 47614 29779317
Type I hypersensitivity 16.30 10.07 20 125527 928 29826003
Posthaemorrhagic hydrocephalus 16.16 10.07 8 125539 90 29826841
Diabetes mellitus 16.07 10.07 106 125441 41759 29785172
Gastritis bacterial 16.05 10.07 10 125537 181 29826750
Hepatitis B 16.04 10.07 3 125544 6069 29820862
Depression 15.94 10.07 494 125053 89943 29736988
Urticaria chronic 15.94 10.07 8 125539 93 29826838
Lip erosion 15.92 10.07 16 125531 593 29826338
Cerebrovascular accident 15.89 10.07 250 125297 83227 29743704
Gastric perforation 15.78 10.07 30 125517 2051 29824880
Extrapyramidal disorder 15.73 10.07 13 125534 10680 29816251
Subdural abscess 15.69 10.07 4 125543 3 29826928
Anosmia 15.59 10.07 30 125517 2070 29824861
Febrile convulsion 15.55 10.07 14 125533 451 29826480
Anterior interosseous syndrome 15.53 10.07 5 125542 15 29826916
Haemophilia 15.53 10.07 5 125542 15 29826916
Musculoskeletal pain 15.49 10.07 198 125349 30742 29796189
Dental operation 15.45 10.07 13 125534 382 29826549
Pleural effusion 15.42 10.07 218 125329 73848 29753083
Respiratory fatigue 15.31 10.07 7 125540 65 29826866
Blood bilirubin unconjugated 15.16 10.07 4 125543 4 29826927
Bradycardia 15.04 10.07 189 125358 65337 29761594
Product dose omission issue 15.00 10.07 282 125265 91349 29735582
Cervicobrachial syndrome 14.93 10.07 12 125535 330 29826601
Clostridium difficile colitis 14.85 10.07 19 125528 12749 29814182
Cytomegalovirus viraemia 14.78 10.07 3 125544 5726 29821205
Coating in mouth 14.69 10.07 7 125540 72 29826859
Epidermolysis 14.58 10.07 11 125536 275 29826656
Oesophageal rupture 14.57 10.07 13 125534 414 29826517
Mycoplasma infection 14.55 10.07 11 125536 276 29826655
Pulmonary embolism 14.54 10.07 235 125312 77900 29749031
Spinal cord infection 14.54 10.07 9 125538 161 29826770
Axillary pain 14.48 10.07 10 125537 217 29826714
Abdominal pain 14.41 10.07 701 124846 134953 29691978
Pneumonia bacterial 14.38 10.07 11 125536 9392 29817539
Meningoencephalitis bacterial 14.33 10.07 8 125539 117 29826814
SJS-TEN overlap 14.28 10.07 7 125540 77 29826854
Oesophageal infection 14.28 10.07 10 125537 222 29826709
Microbiology test abnormal 14.28 10.07 4 125543 6 29826925
Blood ethanol increased 14.13 10.07 12 125535 357 29826574
Exostosis 14.12 10.07 39 125508 3416 29823515
Incorrect route of product administration 14.05 10.07 16 125531 11299 29815632
Staphylococcal abscess 13.96 10.07 15 125532 602 29826329
Transaminases increased 13.89 10.07 155 125392 23302 29803629
Elbow operation 13.81 10.07 8 125539 126 29826805
Oxygen saturation decreased 13.80 10.07 116 125431 43324 29783607
Presbyopia 13.80 10.07 9 125538 177 29826754
Kounis syndrome 13.79 10.07 25 125522 1648 29825283
Application site haematoma 13.79 10.07 6 125541 49 29826882
Mediastinitis 13.73 10.07 14 125533 528 29826403
Spondylitis 13.68 10.07 20 125527 1100 29825831
Neutrophil Pelger-Huet anomaly present 13.68 10.07 10 125537 238 29826693
Hyperglycaemia 13.57 10.07 89 125458 35111 29791820
Posterior reversible encephalopathy syndrome 13.55 10.07 10 125537 8697 29818234
Pruritus genital 13.55 10.07 13 125534 455 29826476
Acute respiratory failure 13.50 10.07 59 125488 25791 29801140
Subdural haematoma 13.47 10.07 38 125509 18934 29807997
Gastric mucosa erythema 13.46 10.07 10 125537 244 29826687
Ureteric obstruction 13.45 10.07 21 125526 1225 29825706
Atrio-oesophageal fistula 13.44 10.07 3 125544 0 29826931
Vestibular ataxia 13.44 10.07 3 125544 0 29826931
Burn oral cavity 13.44 10.07 3 125544 0 29826931
Pigment nephropathy 13.44 10.07 3 125544 0 29826931
Colonic abscess 13.40 10.07 12 125535 384 29826547
Asthmatic crisis 13.38 10.07 13 125534 462 29826469
Cardiac disorder 13.37 10.07 105 125442 39788 29787143
Deep vein thrombosis 13.33 10.07 176 125371 60325 29766606
Lower gastrointestinal haemorrhage 13.32 10.07 67 125480 7837 29819094
Neutropenic sepsis 13.24 10.07 17 125530 11392 29815539
Conjunctival erosion 13.24 10.07 4 125543 9 29826922
Suspected suicide 13.24 10.07 36 125511 3125 29823806
Post transplant lymphoproliferative disorder 13.23 10.07 3 125544 5303 29821628
Mesenteric panniculitis 13.23 10.07 8 125539 137 29826794
Disseminated intravascular coagulation 13.23 10.07 48 125499 22123 29804808
Progressive multifocal leukoencephalopathy 13.21 10.07 11 125536 9002 29817929
Foreign body in throat 13.19 10.07 6 125541 55 29826876
Erythema 13.10 10.07 421 125126 77030 29749901
Orbital oedema 13.08 10.07 8 125539 140 29826791
Dementia 13.04 10.07 20 125527 12441 29814490
Stomatitis 13.02 10.07 97 125450 37182 29789749
Arthritis 13.01 10.07 158 125389 24243 29802688
Neurotoxicity 13.00 10.07 22 125525 13160 29813771
Pupils unequal 13.00 10.07 21 125526 1261 29825670
Torsade de pointes 12.92 10.07 7 125540 7183 29819748
Speech sound disorder 12.91 10.07 6 125541 58 29826873
Heat stroke 12.82 10.07 17 125530 853 29826078
Multiple organ dysfunction syndrome 12.81 10.07 188 125359 63299 29763632
Dermatitis acneiform 12.71 10.07 4 125543 5685 29821246
Apnoea 12.71 10.07 56 125491 6202 29820729
Migraine 12.70 10.07 95 125452 12779 29814152
Hereditary angioedema 12.60 10.07 16 125531 769 29826162
Hiatus hernia 12.59 10.07 61 125486 7029 29819902
Nasal turbinate hypertrophy 12.57 10.07 6 125541 62 29826869
Cataract 12.55 10.07 48 125499 21787 29805144
Congenital skin dimples 12.55 10.07 8 125539 151 29826780
Oesophagitis 12.51 10.07 85 125462 11086 29815845
Antinuclear antibody increased 12.50 10.07 9 125538 209 29826722
Photophobia 12.44 10.07 53 125494 5783 29821148
Thrombosis 12.43 10.07 115 125432 42116 29784815
Complement factor C4 decreased 12.42 10.07 4 125543 12 29826919
Gastrooesophageal reflux disease 12.38 10.07 197 125350 32058 29794873
Ulcer haemorrhage 12.37 10.07 30 125517 2428 29824503
Epiglottitis 12.33 10.07 11 125536 350 29826581
Escherichia pyelonephritis 12.32 10.07 6 125541 65 29826866
Fusobacterium infection 12.32 10.07 6 125541 65 29826866
Muscle injury 12.31 10.07 20 125527 1207 29825724
Rash macular 12.29 10.07 80 125467 10287 29816644
Facet joint syndrome 12.28 10.07 9 125538 215 29826716
Immune reconstitution inflammatory syndrome 12.27 10.07 12 125535 9089 29817842
Capillary nail refill test abnormal 12.27 10.07 5 125542 34 29826897
Focal segmental glomerulosclerosis 12.24 10.07 25 125522 1802 29825129
Electrocardiogram QT shortened 12.23 10.07 8 125539 158 29826773
Arrhythmia 12.22 10.07 85 125462 33084 29793847
Extra dose administered 12.22 10.07 33 125514 2853 29824078
Ear canal stenosis 12.18 10.07 4 125543 13 29826918
Cardio-respiratory arrest 12.16 10.07 168 125379 57138 29769793
Atrial septal defect 12.15 10.07 58 125489 6643 29820288
Hepatic cirrhosis 12.15 10.07 31 125516 15968 29810963
Allergic respiratory disease 12.03 10.07 5 125542 36 29826895
Gastrointestinal ulcer 11.96 10.07 24 125523 1708 29825223
Ear injury 11.91 10.07 5 125542 37 29826894
Necrotising panniculitis 11.91 10.07 5 125542 37 29826894
Inflammation 11.90 10.07 143 125404 21883 29805048
Anuria 11.86 10.07 79 125468 10237 29816694
Bronchospasm 11.78 10.07 79 125468 10259 29816672
Purpura fulminans 11.78 10.07 7 125540 116 29826815
Parkinsonism 11.77 10.07 8 125539 7261 29819670
Orthostatic hypotension 11.76 10.07 56 125491 23923 29803008
Fall 11.72 10.07 633 124914 181239 29645692
Intentional product use issue 11.71 10.07 97 125450 36343 29790588
Blood pressure systolic increased 11.69 10.07 29 125518 15081 29811850
Pulmonary fistula 11.68 10.07 5 125542 39 29826892
Hypertensive emergency 11.68 10.07 16 125531 828 29826103
Pelvic fluid collection 11.57 10.07 7 125540 120 29826811
Decreased appetite 11.56 10.07 512 125035 149398 29677533
Right ventricular failure 11.54 10.07 10 125537 8026 29818905
Tension headache 11.53 10.07 20 125527 1273 29825658
Full blood count decreased 11.52 10.07 31 125516 15686 29811245
Inadequate analgesia 11.50 10.07 31 125516 2677 29824254
Candida infection 11.48 10.07 30 125517 15332 29811599
Hypothermia 11.44 10.07 74 125473 9493 29817438
Neoplasm progression 11.44 10.07 38 125509 17985 29808946
Perineurial cyst 11.37 10.07 3 125544 3 29826928
Peritonsillitis 11.37 10.07 3 125544 3 29826928
Kernicterus 11.37 10.07 3 125544 3 29826928
Vertebral artery hypoplasia 11.37 10.07 3 125544 3 29826928
Pneumonitis 11.31 10.07 68 125479 27386 29799545
Necrotising colitis 11.31 10.07 17 125530 959 29825972
Mucosal inflammation 11.30 10.07 78 125469 30416 29796515
Large intestinal ulcer 11.21 10.07 23 125524 1663 29825268
Retinopathy of prematurity 11.17 10.07 7 125540 128 29826803
Bladder neck obstruction 11.17 10.07 7 125540 128 29826803
Tongue injury 11.13 10.07 7 125540 129 29826802
Haematotoxicity 11.10 10.07 6 125541 6164 29820767
Haemorrhoids thrombosed 11.07 10.07 8 125539 187 29826744
Liver disorder 11.03 10.07 76 125471 29646 29797285
Streptococcal sepsis 11.00 10.07 20 125527 1322 29825609
Cardiomyopathy 11.00 10.07 30 125517 15113 29811818
Lung neoplasm malignant 10.97 10.07 30 125517 15102 29811829
Anaphylactic shock 10.97 10.07 98 125449 13895 29813036
Neck pain 10.89 10.07 135 125412 20809 29806122
Wrist deformity 10.86 10.07 10 125537 332 29826599
Asthenia 10.82 10.07 790 124757 220500 29606431
Dystonia 10.78 10.07 15 125532 9712 29817219
Anxiety 10.74 10.07 470 125077 89401 29737530
Generalised oedema 10.68 10.07 21 125526 11864 29815067
Intervertebral disc degeneration 10.67 10.07 47 125500 5204 29821727
Ligament injury 10.66 10.07 10 125537 340 29826591
Social anxiety disorder 10.65 10.07 9 125538 266 29826665
Breath odour 10.61 10.07 15 125532 800 29826131
Oral mucosa erosion 10.57 10.07 15 125532 803 29826128
Bone disorder 10.57 10.07 56 125491 6685 29820246
Circumoral oedema 10.53 10.07 5 125542 51 29826880
Paranasal sinus mucosal hypertrophy 10.53 10.07 5 125542 51 29826880
Pneumonia fungal 10.52 10.07 5 125542 5528 29821403
Testicular abscess 10.52 10.07 4 125543 22 29826909
Nail disorder 10.49 10.07 23 125524 1742 29825189
Urinary tract infection 10.47 10.07 232 125315 73427 29753504
Laryngeal discomfort 10.41 10.07 7 125540 145 29826786
Pain in extremity 10.36 10.07 563 124984 109658 29717273
Xanthelasma 10.33 10.07 6 125541 95 29826836
Pharyngitis streptococcal 10.31 10.07 24 125523 1891 29825040
Eye oedema 10.20 10.07 14 125533 726 29826205
Post concussion syndrome 10.20 10.07 5 125542 55 29826876
Laryngeal leukoplakia 10.20 10.07 5 125542 55 29826876
Product dispensing error 10.20 10.07 6 125541 5883 29821048
Rhinitis 10.19 10.07 42 125505 4517 29822414
Paraesthesia 10.17 10.07 299 125248 54028 29772903
Anhidrosis 10.17 10.07 6 125541 98 29826833
Fibromuscular dysplasia 10.17 10.07 3 125544 6 29826925
Congenital nipple anomaly 10.17 10.07 3 125544 6 29826925
Dyskinesia 10.13 10.07 52 125495 21782 29805149
Therapy non-responder 10.11 10.07 77 125470 29376 29797555
Tonsillar hypertrophy 10.10 10.07 12 125535 538 29826393
Double stranded DNULL antibody 10.10 10.07 4 125543 25 29826906

Pharmacologic Action:

SourceCodeDescription
ATC C01EB16 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
OTHER CARDIAC PREPARATIONS
Other cardiac preparations
ATC G02CC01 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
OTHER GYNECOLOGICALS
Antiinflammatory products for vaginal administration
ATC M01AE01 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M02AA13 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC R02AX02 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Other throat preparations
ATC M01AE51 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC N02AJ08 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ19 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drugs
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:48578 free-radical scavenger
CHEBI has role CHEBI:50629 cyclooxygenase-2 inhibitor
CHEBI has role CHEBI:50630 cyclooxygenase-1 inhibitor
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Pain indication 22253000
Rheumatoid arthritis indication 69896004 DOID:7148
Severe pain indication 76948002
Patent ductus arteriosus indication 83330001 DOID:13832
Headache disorder indication 230461009
Dysmenorrhea indication 266599000
Influenza-like symptoms indication 315642008
Fever indication 386661006
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001
Acute postoperative pain indication 107401000119105
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Constipation contraindication 14760008 DOID:2089
Mood swings contraindication 18963009
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Agoraphobia contraindication 70691001 DOID:593
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Atrophic gastritis contraindication 84568007 DOID:8929
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Acute abdominal pain contraindication 116290004
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Thromboembolic disorder contraindication 371039008
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Smokes tobacco daily contraindication 449868002
Significant Bleeding contraindication
Acute Thromboembolic Stroke contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
250MG;125MG ADVIL DUAL ACTION WITH ACETAMINOPHEN GLAXOSMITHKLINE N211733 Feb. 28, 2020 OTC TABLET ORAL Feb. 28, 2023 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5.14 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.12 WOMBAT-PK CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 4.48 CHEMBL
Cytochrome P450 2C9 Enzyme Ki 4.30 WOMBAT-PK
Arachidonate 5-lipoxygenase Enzyme WOMBAT-PK
Sodium-coupled monocarboxylate transporter 1 Transporter INHIBITOR IC50 4.20 IUPHAR
Interleukin-8 Cytokine IC50 7.30 CHEMBL
Acid-sensing ion channel 1 Ion channel BLOCKER IC50 3.53 SCIENTIFIC LITERATURE
Aldo-keto reductase family 1 member C2 Enzyme IC50 4.37 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.96 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.07 CHEMBL
Serum albumin Secreted IC50 5.52 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 4.32 CHEMBL
Dehydrogenase/reductase SDR family member 9 Unclassified IC50 4 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.54 CHEMBL
Cyclooxygenase Enzyme IC50 5.70 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 5.05 CHEMBL
Solute carrier family 22 member 20 Transporter Ki 5.96 CHEMBL
Solute carrier family 22 member 6 Transporter Ki 5.33 CHEMBL
Prostaglandin G/H synthase 1 Enzyme Ki 5.05 CHEMBL
Prostaglandin-H2 D-isomerase Enzyme IC50 4.89 CHEMBL

External reference:

IDSource
4032936 VUID
N0000189536 NUI
D00126 KEGG_DRUG
57469-77-9 SECONDARY_CAS_RN
4017840 VANDF
4032936 VANDF
C0020740 UMLSCUI
CHEBI:132922 CHEBI
IBP PDB_CHEM_ID
CHEMBL521 ChEMBL_ID
CHEMBL427526 ChEMBL_ID
CHEMBL1201141 ChEMBL_ID
CHEMBL3989408 ChEMBL_ID
CHEMBL1241153 ChEMBL_ID
CHEMBL175 ChEMBL_ID
DB01050 DRUGBANK_ID
D007052 MESH_DESCRIPTOR_UI
2713 IUPHAR_LIGAND_ID
C016106 MESH_SUPPLEMENTAL_RECORD_UI
2118 INN_ID
WK2XYI10QM UNII
3672 PUBCHEM_CID
1429044 RXNORM
2133 MMSL
240518 MMSL
32273 MMSL
4862 MMSL
7027 MMSL
82565 MMSL
d00015 MMSL
002377 NDDF
006088 NDDF
006232 NDDF
38268001 SNOMEDCT_US
387207008 SNOMEDCT_US
425516000 SNOMEDCT_US
725863000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense ibuprofen pm HUMAN OTC DRUG LABEL 2 0113-0050 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Good Sense ibuprofeninfants HUMAN OTC DRUG LABEL 1 0113-0057 SUSPENSION 50 mg ORAL ANDA 15 sections
Good Sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0074 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
good sense ibuprofenchildrens HUMAN OTC DRUG LABEL 1 0113-0166 SUSPENSION 100 mg ORAL ANDA 15 sections
good sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0298 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 16 sections
Good Sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0517 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
good sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0604 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
good sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0647 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Good Sense IbuprofenChildrens HUMAN OTC DRUG LABEL 1 0113-0660 SUSPENSION 100 mg ORAL ANDA 15 sections
Good Sense Ibuprofen HUMAN OTC DRUG LABEL 1 0113-0685 SUSPENSION 100 mg ORAL ANDA 15 sections
Basic Care ibuprofen HUMAN OTC DRUG LABEL 1 0113-0788 TABLET, CHEWABLE 100 mg ORAL ANDA 15 sections
good sense ibuprofenchildrens HUMAN OTC DRUG LABEL 1 0113-0897 SUSPENSION 100 mg ORAL ANDA 15 sections
Good Sense Ibuprofen HUMAN OTC DRUG LABEL 1 0113-1212 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
basic care childrens ibuprofen HUMAN OTC DRUG LABEL 1 0113-1461 TABLET, CHEWABLE 100 mg ORAL ANDA 15 sections
Good Sense Childrens Ibuprofen HUMAN OTC DRUG LABEL 1 0113-2461 TABLET, CHEWABLE 100 mg ORAL ANDA 15 sections
basic care ibuprofen HUMAN OTC DRUG LABEL 1 0113-7131 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 16 sections
basic care ibuprofen HUMAN OTC DRUG LABEL 1 0113-7517 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Basic Care Ibuprofen HUMAN OTC DRUG LABEL 1 0113-7604 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
basic care childrens ibuprofen HUMAN OTC DRUG LABEL 1 0113-7660 SUSPENSION 100 mg ORAL ANDA 15 sections
Basic Care childrens ibuprofen HUMAN OTC DRUG LABEL 1 0113-7897 SUSPENSION 100 mg ORAL ANDA 15 sections
Childrens Ibuprofen Oral Suspension HUMAN OTC DRUG LABEL 1 0121-0914 SUSPENSION 100 mg ORAL ANDA 16 sections
Childrens Ibuprofen HUMAN OTC DRUG LABEL 1 0121-0917 SUSPENSION 100 mg ORAL ANDA 15 sections
Ibuprofen HUMAN PRESCRIPTION DRUG LABEL 1 0121-0918 SUSPENSION 100 mg ORAL ANDA 28 sections
IBUPROFEN HUMAN PRESCRIPTION DRUG LABEL 1 0121-1548 SUSPENSION 100 mg ORAL ANDA 28 sections
Childrens Ibuprofen Oral Suspension HUMAN OTC DRUG LABEL 1 0121-1828 SUSPENSION 100 mg ORAL ANDA 16 sections
Childrens Ibuprofen HUMAN OTC DRUG LABEL 1 0121-1836 SUSPENSION 100 mg ORAL ANDA 16 sections
IBUPROFEN HUMAN PRESCRIPTION DRUG LABEL 1 0121-4774 SUSPENSION 100 mg ORAL ANDA 28 sections
IBUPROFEN Human OTC Drug Label 1 0363-0003 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 16 sections
Ibuprofen PM HUMAN OTC DRUG LABEL 2 0363-0050 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Dye-Free Ibuprofen 200 HUMAN OTC DRUG LABEL 1 0363-0103 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 17 sections