Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory agents, ibuprofen derivatives | 1407 | 15687-27-1 |
Dose | Unit | Route |
---|---|---|
30 | mg | P |
1.20 | g | O |
1.20 | g | P |
1.20 | g | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.04 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 193.90 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 85 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.15 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.82 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 19, 1974 | FDA | ||
Jan. 19, 2018 | PMDA | Senju Pharmaceutical Co., Ltd. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intentional overdose | 825.51 | 9.72 | 1413 | 305927 | 61091 | 50236693 |
Cholecystitis chronic | 525.36 | 9.72 | 450 | 306890 | 9219 | 50288565 |
Muscle injury | 503.00 | 9.72 | 849 | 306491 | 36262 | 50261522 |
Angioedema | 492.28 | 9.72 | 848 | 306492 | 36828 | 50260956 |
Folliculitis | 480.28 | 9.72 | 858 | 306482 | 38367 | 50259417 |
Injury | 475.49 | 9.72 | 970 | 306370 | 47955 | 50249829 |
Irritable bowel syndrome | 469.63 | 9.72 | 994 | 306346 | 50447 | 50247337 |
Lower respiratory tract infection | 373.91 | 9.72 | 1350 | 305990 | 93851 | 50203933 |
Death | 353.82 | 9.72 | 921 | 306419 | 324458 | 49973326 |
Sleep disorder due to general medical condition, insomnia type | 333.76 | 9.72 | 647 | 306693 | 30800 | 50266984 |
Blister | 322.51 | 9.72 | 1196 | 306144 | 84222 | 50213562 |
Impaired healing | 295.81 | 9.72 | 1015 | 306325 | 68771 | 50229013 |
Abdominal pain upper | 288.59 | 9.72 | 1804 | 305536 | 157505 | 50140279 |
Urticaria | 285.25 | 9.72 | 1545 | 305795 | 128016 | 50169768 |
Off label use | 283.48 | 9.72 | 1706 | 305634 | 472720 | 49825064 |
Emotional distress | 282.81 | 9.72 | 572 | 306768 | 28091 | 50269693 |
Pneumonia | 276.06 | 9.72 | 1271 | 306069 | 377130 | 49920654 |
Pruritus | 268.04 | 9.72 | 2765 | 304575 | 280803 | 50016981 |
Gastrointestinal disorder | 255.52 | 9.72 | 1194 | 306146 | 93262 | 50204522 |
Suicide attempt | 254.83 | 9.72 | 792 | 306548 | 50940 | 50246844 |
Muscle spasticity | 240.60 | 9.72 | 399 | 306941 | 16785 | 50280999 |
Sinusitis | 239.81 | 9.72 | 1815 | 305525 | 168743 | 50129041 |
Ill-defined disorder | 232.52 | 9.72 | 796 | 306544 | 53858 | 50243926 |
Drug hypersensitivity | 232.09 | 9.72 | 2437 | 304903 | 248573 | 50049211 |
Uterine perforation | 219.17 | 9.72 | 231 | 307109 | 6184 | 50291600 |
Tubulointerstitial nephritis | 218.09 | 9.72 | 357 | 306983 | 14854 | 50282930 |
Ear pain | 205.10 | 9.72 | 499 | 306841 | 27784 | 50270000 |
Overdose | 187.13 | 9.72 | 1140 | 306200 | 98587 | 50199197 |
Aspirin-exacerbated respiratory disease | 184.36 | 9.72 | 95 | 307245 | 779 | 50297005 |
Deep vein thrombosis | 176.21 | 9.72 | 896 | 306444 | 72408 | 50225376 |
Deafness transitory | 173.91 | 9.72 | 118 | 307222 | 1678 | 50296106 |
Renal tubular acidosis | 173.36 | 9.72 | 111 | 307229 | 1423 | 50296361 |
Stomatitis | 173.07 | 9.72 | 1131 | 306209 | 100213 | 50197571 |
Gallbladder disorder | 172.19 | 9.72 | 340 | 307000 | 16402 | 50281382 |
Peripheral swelling | 161.78 | 9.72 | 1937 | 305403 | 203999 | 50093785 |
Duodenal ulcer perforation | 158.33 | 9.72 | 622 | 306718 | 44989 | 50252795 |
Febrile neutropenia | 152.23 | 9.72 | 223 | 307117 | 97444 | 50200340 |
Cardiac failure | 143.29 | 9.72 | 150 | 307190 | 75890 | 50221894 |
Biliary dyskinesia | 143.26 | 9.72 | 121 | 307219 | 2429 | 50295355 |
Fall | 138.57 | 9.72 | 1333 | 306007 | 333599 | 49964185 |
Completed suicide | 137.82 | 9.72 | 1314 | 306026 | 130575 | 50167209 |
Toxicity to various agents | 136.33 | 9.72 | 1926 | 305414 | 210573 | 50087211 |
Cardiac failure congestive | 136.12 | 9.72 | 188 | 307152 | 84194 | 50213590 |
Interstitial lung disease | 135.66 | 9.72 | 77 | 307263 | 53099 | 50244685 |
Body temperature increased | 135.48 | 9.72 | 459 | 306881 | 30882 | 50266902 |
Lip oedema | 131.09 | 9.72 | 127 | 307213 | 3066 | 50294718 |
Night sweats | 129.03 | 9.72 | 473 | 306867 | 33101 | 50264683 |
Gastrointestinal pain | 124.97 | 9.72 | 196 | 307144 | 7860 | 50289924 |
Haematemesis | 123.35 | 9.72 | 410 | 306930 | 27315 | 50270469 |
Treatment failure | 123.03 | 9.72 | 426 | 306914 | 137211 | 50160573 |
Respiratory disorder | 122.07 | 9.72 | 442 | 306898 | 30745 | 50267039 |
Drug ineffective | 119.91 | 9.72 | 3932 | 303408 | 815401 | 49482383 |
Metabolic acidosis | 118.58 | 9.72 | 509 | 306831 | 38316 | 50259468 |
Helicobacter infection | 117.65 | 9.72 | 605 | 306735 | 49097 | 50248687 |
Cholelithiasis | 116.11 | 9.72 | 498 | 306842 | 37475 | 50260309 |
Gastric ulcer | 113.14 | 9.72 | 335 | 307005 | 20970 | 50276814 |
Malignant neoplasm progression | 112.68 | 9.72 | 149 | 307191 | 67975 | 50229809 |
Neutropenia | 105.76 | 9.72 | 500 | 306840 | 147465 | 50150319 |
Intentional self-injury | 104.79 | 9.72 | 344 | 306996 | 22768 | 50275016 |
Oligohydramnios | 103.57 | 9.72 | 150 | 307190 | 5600 | 50292184 |
Kounis syndrome | 99.27 | 9.72 | 71 | 307269 | 1104 | 50296680 |
Stevens-Johnson syndrome | 97.94 | 9.72 | 323 | 307017 | 21429 | 50276355 |
Atrial fibrillation | 95.63 | 9.72 | 308 | 307032 | 101437 | 50196347 |
Nasopharyngitis | 94.97 | 9.72 | 1673 | 305667 | 191254 | 50106530 |
Pulmonary embolism | 93.04 | 9.72 | 986 | 306354 | 100718 | 50197066 |
Hospitalisation | 91.96 | 9.72 | 170 | 307170 | 67767 | 50230017 |
Sepsis | 88.76 | 9.72 | 460 | 306880 | 132465 | 50165319 |
Vomiting | 87.28 | 9.72 | 3522 | 303818 | 457236 | 49840548 |
Toxic epidermal necrolysis | 85.12 | 9.72 | 301 | 307039 | 20691 | 50277093 |
Platelet count decreased | 83.88 | 9.72 | 321 | 307019 | 100405 | 50197379 |
Meningitis aseptic | 81.72 | 9.72 | 113 | 307227 | 4039 | 50293745 |
Hypersensitivity | 81.03 | 9.72 | 1792 | 305548 | 213369 | 50084415 |
Hypervolaemia | 80.73 | 9.72 | 27 | 307313 | 25472 | 50272312 |
Foreign body in throat | 80.51 | 9.72 | 29 | 307311 | 83 | 50297701 |
Joint swelling | 78.98 | 9.72 | 1999 | 305341 | 243287 | 50054497 |
Infection | 78.84 | 9.72 | 1482 | 305858 | 171472 | 50126312 |
Pain | 78.77 | 9.72 | 4281 | 303059 | 574622 | 49723162 |
Thrombocytopenia | 76.95 | 9.72 | 457 | 306883 | 127216 | 50170568 |
Disease progression | 76.33 | 9.72 | 311 | 307029 | 95555 | 50202229 |
Acute kidney injury | 76.21 | 9.72 | 1868 | 305472 | 226190 | 50071594 |
Gallbladder injury | 76.00 | 9.72 | 63 | 307277 | 1231 | 50296553 |
Anhedonia | 75.50 | 9.72 | 174 | 307166 | 9350 | 50288434 |
Gastric ulcer perforation | 75.12 | 9.72 | 58 | 307282 | 1019 | 50296765 |
Renal impairment | 74.65 | 9.72 | 224 | 307116 | 75437 | 50222347 |
Eyelid oedema | 74.00 | 9.72 | 172 | 307168 | 9294 | 50288490 |
Fixed eruption | 73.89 | 9.72 | 52 | 307288 | 787 | 50296997 |
Peritonsillar abscess | 73.45 | 9.72 | 43 | 307297 | 464 | 50297320 |
Anaemia | 72.33 | 9.72 | 1088 | 306252 | 251368 | 50046416 |
Drug resistance | 71.82 | 9.72 | 14 | 307326 | 18975 | 50278809 |
Diarrhoea | 71.28 | 9.72 | 2888 | 304452 | 585588 | 49712196 |
Upper gastrointestinal haemorrhage | 70.31 | 9.72 | 236 | 307104 | 15799 | 50281985 |
Face oedema | 69.95 | 9.72 | 253 | 307087 | 17586 | 50280198 |
Wound closure | 69.41 | 9.72 | 26 | 307314 | 86 | 50297698 |
Pharyngitis | 68.43 | 9.72 | 248 | 307092 | 17255 | 50280529 |
Duodenal ulcer | 67.75 | 9.72 | 136 | 307204 | 6639 | 50291145 |
Bezoar | 67.70 | 9.72 | 60 | 307280 | 1288 | 50296496 |
Therapeutic product effect decreased | 64.83 | 9.72 | 1174 | 306166 | 134876 | 50162908 |
Vanishing bile duct syndrome | 64.43 | 9.72 | 43 | 307297 | 594 | 50297190 |
Red blood cell sedimentation rate abnormal | 64.07 | 9.72 | 11 | 307329 | 16332 | 50281452 |
Hypoaldosteronism | 64.06 | 9.72 | 27 | 307313 | 131 | 50297653 |
Lip swelling | 63.40 | 9.72 | 308 | 307032 | 24428 | 50273356 |
Femur fracture | 61.88 | 9.72 | 82 | 307258 | 37382 | 50260402 |
Confusional state | 61.79 | 9.72 | 1522 | 305818 | 184406 | 50113378 |
Plasma cell myeloma | 61.02 | 9.72 | 60 | 307280 | 31262 | 50266522 |
Enthesopathy | 61.02 | 9.72 | 135 | 307205 | 7058 | 50290726 |
Haemoglobin decreased | 60.53 | 9.72 | 488 | 306852 | 126728 | 50171056 |
Anxiety | 59.36 | 9.72 | 1455 | 305885 | 176151 | 50121633 |
Malaise | 58.18 | 9.72 | 1572 | 305768 | 333960 | 49963824 |
Gastritis | 58.01 | 9.72 | 371 | 306969 | 32612 | 50265172 |
Herpes zoster | 57.37 | 9.72 | 228 | 307112 | 70558 | 50227226 |
Osteotomy | 57.32 | 9.72 | 27 | 307313 | 178 | 50297606 |
Weight increased | 57.09 | 9.72 | 1618 | 305722 | 200273 | 50097511 |
Cytomegalovirus infection | 56.90 | 9.72 | 19 | 307321 | 17943 | 50279841 |
Orthostatic hypotension | 56.83 | 9.72 | 57 | 307283 | 29424 | 50268360 |
Fluid retention | 56.66 | 9.72 | 141 | 307199 | 50508 | 50247276 |
Myocardial infarction | 56.13 | 9.72 | 314 | 307026 | 88713 | 50209071 |
Sleep disorder | 55.99 | 9.72 | 563 | 306777 | 56720 | 50241064 |
Urinary tract infection | 55.38 | 9.72 | 992 | 306348 | 223028 | 50074756 |
Oesophageal obstruction | 55.15 | 9.72 | 34 | 307306 | 406 | 50297378 |
Wrong technique in product usage process | 55.00 | 9.72 | 164 | 307176 | 55346 | 50242438 |
Melaena | 54.77 | 9.72 | 314 | 307026 | 26550 | 50271234 |
Analgesic drug level increased | 53.29 | 9.72 | 59 | 307281 | 1672 | 50296112 |
Chronic obstructive pulmonary disease | 52.85 | 9.72 | 158 | 307182 | 53277 | 50244507 |
Osteoporosis | 51.73 | 9.72 | 123 | 307217 | 44756 | 50253028 |
White blood cell count decreased | 51.36 | 9.72 | 457 | 306883 | 116265 | 50181519 |
Cardiac disorder | 50.98 | 9.72 | 116 | 307224 | 42863 | 50254921 |
Gastrointestinal haemorrhage | 50.75 | 9.72 | 674 | 306666 | 72647 | 50225137 |
Clostridium difficile infection | 50.41 | 9.72 | 48 | 307292 | 25391 | 50272393 |
Biliary colic | 50.15 | 9.72 | 79 | 307261 | 3180 | 50294604 |
Product use issue | 50.01 | 9.72 | 624 | 306716 | 148851 | 50148933 |
Bone marrow failure | 49.26 | 9.72 | 57 | 307283 | 27567 | 50270217 |
Product prescribing error | 48.78 | 9.72 | 254 | 307086 | 20707 | 50277077 |
Pulmonary infarction | 48.30 | 9.72 | 66 | 307274 | 2332 | 50295452 |
Pulmonary arterial hypertension | 48.23 | 9.72 | 32 | 307308 | 20287 | 50277497 |
Oxygen saturation decreased | 48.01 | 9.72 | 255 | 307085 | 72993 | 50224791 |
Gallbladder cholesterolosis | 47.98 | 9.72 | 38 | 307302 | 694 | 50297090 |
Ear infection | 47.46 | 9.72 | 295 | 307045 | 25675 | 50272109 |
Acute lung injury | 47.30 | 9.72 | 50 | 307290 | 1343 | 50296441 |
Neuropathy peripheral | 47.01 | 9.72 | 369 | 306971 | 96388 | 50201396 |
Transplant rejection | 46.46 | 9.72 | 3 | 307337 | 9606 | 50288178 |
Pancytopenia | 45.87 | 9.72 | 310 | 307030 | 83720 | 50214064 |
Pleural effusion | 45.72 | 9.72 | 298 | 307042 | 81156 | 50216628 |
Neutrophil count decreased | 45.58 | 9.72 | 136 | 307204 | 45890 | 50251894 |
Ductus arteriosus premature closure | 45.53 | 9.72 | 27 | 307313 | 299 | 50297485 |
Self-medication | 44.39 | 9.72 | 62 | 307278 | 2237 | 50295547 |
Hypomagnesaemia | 44.37 | 9.72 | 45 | 307295 | 23111 | 50274673 |
Shoulder arthroplasty | 44.21 | 9.72 | 77 | 307263 | 3371 | 50294413 |
Pneumonia aspiration | 43.36 | 9.72 | 76 | 307264 | 30928 | 50266856 |
Septic shock | 43.32 | 9.72 | 189 | 307151 | 56986 | 50240798 |
Jejunal ulcer | 43.27 | 9.72 | 18 | 307322 | 84 | 50297700 |
Acute myeloid leukaemia | 42.68 | 9.72 | 19 | 307321 | 15055 | 50282729 |
Embedded device | 42.59 | 9.72 | 68 | 307272 | 2769 | 50295015 |
Macular degeneration | 42.56 | 9.72 | 17 | 307323 | 14371 | 50283413 |
Dementia | 42.49 | 9.72 | 22 | 307318 | 15975 | 50281809 |
Contusion | 42.37 | 9.72 | 935 | 306405 | 111248 | 50186536 |
Swelling | 42.23 | 9.72 | 1554 | 305786 | 199318 | 50098466 |
Insomnia | 42.06 | 9.72 | 1374 | 305966 | 173491 | 50124293 |
Red blood cell sedimentation rate | 42.03 | 9.72 | 77 | 307263 | 3509 | 50294275 |
Medication overuse headache | 41.70 | 9.72 | 33 | 307307 | 602 | 50297182 |
Acute hepatic failure | 41.47 | 9.72 | 197 | 307143 | 15480 | 50282304 |
Bone erosion | 41.39 | 9.72 | 10 | 307330 | 11677 | 50286107 |
Medical device discomfort | 41.34 | 9.72 | 51 | 307289 | 1626 | 50296158 |
Heavy menstrual bleeding | 40.92 | 9.72 | 195 | 307145 | 15342 | 50282442 |
Rash | 40.86 | 9.72 | 3134 | 304206 | 434337 | 49863447 |
Pneumocystis jirovecii pneumonia | 40.71 | 9.72 | 19 | 307321 | 14644 | 50283140 |
Tenosynovitis | 40.71 | 9.72 | 149 | 307191 | 10416 | 50287368 |
Gastric perforation | 40.00 | 9.72 | 47 | 307293 | 1423 | 50296361 |
Myelodysplastic syndrome | 39.91 | 9.72 | 21 | 307319 | 15111 | 50282673 |
Cholecystitis acute | 39.90 | 9.72 | 114 | 307226 | 6992 | 50290792 |
Bradycardia | 39.65 | 9.72 | 229 | 307111 | 64197 | 50233587 |
Functional gastrointestinal disorder | 39.20 | 9.72 | 73 | 307267 | 3369 | 50294415 |
Pulmonary hypertension | 38.98 | 9.72 | 91 | 307249 | 33326 | 50264458 |
Pelvic pain | 38.96 | 9.72 | 153 | 307187 | 11060 | 50286724 |
Leukopenia | 38.94 | 9.72 | 245 | 307095 | 67283 | 50230501 |
Abdominal pain lower | 38.43 | 9.72 | 245 | 307095 | 21511 | 50276273 |
Neurotoxicity | 38.08 | 9.72 | 21 | 307319 | 14719 | 50283065 |
Device related infection | 37.82 | 9.72 | 42 | 307298 | 20693 | 50277091 |
Hyponatraemia | 37.78 | 9.72 | 387 | 306953 | 95752 | 50202032 |
Foetal acidosis | 37.65 | 9.72 | 11 | 307329 | 11 | 50297773 |
Productive cough | 37.64 | 9.72 | 178 | 307162 | 52516 | 50245268 |
Foot operation | 37.59 | 9.72 | 95 | 307245 | 5415 | 50292369 |
Lemierre syndrome | 37.42 | 9.72 | 16 | 307324 | 81 | 50297703 |
Abdominal pain | 37.27 | 9.72 | 1773 | 305567 | 234455 | 50063329 |
Respiratory failure | 37.10 | 9.72 | 364 | 306976 | 90817 | 50206967 |
Dehydration | 37.03 | 9.72 | 677 | 306663 | 151772 | 50146012 |
Pelvic venous thrombosis | 36.88 | 9.72 | 43 | 307297 | 1291 | 50296493 |
Premature delivery | 36.87 | 9.72 | 54 | 307286 | 23609 | 50274175 |
Duodenal ulcer haemorrhage | 36.84 | 9.72 | 55 | 307285 | 2111 | 50295673 |
Cough | 36.81 | 9.72 | 1150 | 306190 | 240114 | 50057670 |
Tendonitis | 36.54 | 9.72 | 199 | 307141 | 16506 | 50281278 |
Cholesterosis | 35.88 | 9.72 | 26 | 307314 | 413 | 50297371 |
Blood pressure increased | 35.62 | 9.72 | 581 | 306759 | 132551 | 50165233 |
General physical health deterioration | 35.49 | 9.72 | 1124 | 306216 | 141310 | 50156474 |
Hypocalcaemia | 35.49 | 9.72 | 68 | 307272 | 26748 | 50271036 |
Dyspnoea exertional | 35.47 | 9.72 | 175 | 307165 | 51058 | 50246726 |
Right ventricular failure | 35.13 | 9.72 | 27 | 307313 | 15866 | 50281918 |
Bronchitis | 35.13 | 9.72 | 434 | 306906 | 103725 | 50194059 |
Tongue disorder | 34.69 | 9.72 | 129 | 307211 | 9087 | 50288697 |
Alopecia | 34.54 | 9.72 | 1180 | 306160 | 243867 | 50053917 |
Multiple organ dysfunction syndrome | 34.24 | 9.72 | 173 | 307167 | 50164 | 50247620 |
Diabetes mellitus | 34.23 | 9.72 | 167 | 307173 | 48866 | 50248918 |
Hepatitis cholestatic | 34.22 | 9.72 | 98 | 307242 | 6019 | 50291765 |
Hip fracture | 34.10 | 9.72 | 66 | 307274 | 25865 | 50271919 |
Transfusion | 33.90 | 9.72 | 18 | 307322 | 12887 | 50284897 |
Acute generalised exanthematous pustulosis | 33.55 | 9.72 | 125 | 307215 | 8813 | 50288971 |
Oedema peripheral | 32.80 | 9.72 | 720 | 306620 | 157241 | 50140543 |
Hypoglycaemia | 32.67 | 9.72 | 191 | 307149 | 53390 | 50244394 |
Product dose omission issue | 32.66 | 9.72 | 858 | 306482 | 182980 | 50114804 |
Tongue oedema | 32.50 | 9.72 | 72 | 307268 | 3767 | 50294017 |
Open globe injury | 32.43 | 9.72 | 12 | 307328 | 38 | 50297746 |
Laryngeal oedema | 32.29 | 9.72 | 85 | 307255 | 4968 | 50292816 |
Sedation complication | 32.04 | 9.72 | 7 | 307333 | 8759 | 50289025 |
Eosinophilic oesophagitis | 32.01 | 9.72 | 20 | 307320 | 245 | 50297539 |
Ankylosing spondylitis | 31.90 | 9.72 | 106 | 307234 | 7059 | 50290725 |
Hypotension | 31.78 | 9.72 | 1140 | 306200 | 234329 | 50063455 |
Pharyngeal abscess | 31.66 | 9.72 | 20 | 307320 | 250 | 50297534 |
Suspected suicide | 31.11 | 9.72 | 87 | 307253 | 5270 | 50292514 |
Rheumatoid factor positive | 30.26 | 9.72 | 178 | 307162 | 49681 | 50248103 |
Pain in jaw | 29.74 | 9.72 | 126 | 307214 | 38302 | 50259482 |
Foreign body in gastrointestinal tract | 29.68 | 9.72 | 11 | 307329 | 35 | 50297749 |
Ascites | 29.37 | 9.72 | 115 | 307225 | 35746 | 50262038 |
Renal papillary necrosis | 29.34 | 9.72 | 18 | 307322 | 213 | 50297571 |
Exposure during pregnancy | 29.19 | 9.72 | 538 | 306802 | 120477 | 50177307 |
Poisoning | 29.19 | 9.72 | 151 | 307189 | 12278 | 50285506 |
Headache | 29.00 | 9.72 | 3506 | 303834 | 503029 | 49794755 |
Condition aggravated | 28.49 | 9.72 | 1494 | 305846 | 295564 | 50002220 |
Neonatal cardiac failure | 28.44 | 9.72 | 8 | 307332 | 6 | 50297778 |
Multiple sclerosis | 28.11 | 9.72 | 217 | 307123 | 20276 | 50277508 |
Therapeutic product effect incomplete | 28.04 | 9.72 | 389 | 306951 | 91126 | 50206658 |
Musculoskeletal disorder | 27.99 | 9.72 | 191 | 307149 | 17158 | 50280626 |
Brain death | 27.99 | 9.72 | 56 | 307284 | 2727 | 50295057 |
Device expulsion | 27.94 | 9.72 | 86 | 307254 | 28736 | 50269048 |
Duodenitis haemorrhagic | 27.89 | 9.72 | 8 | 307332 | 7 | 50297777 |
Bronchopulmonary aspergillosis | 27.88 | 9.72 | 6 | 307334 | 7586 | 50290198 |
Mucosal inflammation | 27.85 | 9.72 | 137 | 307203 | 40005 | 50257779 |
Gallbladder hypofunction | 27.63 | 9.72 | 24 | 307316 | 501 | 50297283 |
Injection site pain | 27.59 | 9.72 | 491 | 306849 | 110533 | 50187251 |
Intestinal obstruction | 27.56 | 9.72 | 76 | 307264 | 26307 | 50271477 |
Gastritis erosive | 27.51 | 9.72 | 81 | 307259 | 5053 | 50292731 |
Serotonin syndrome | 27.48 | 9.72 | 69 | 307271 | 24644 | 50273140 |
Maternal exposure during pregnancy | 27.25 | 9.72 | 750 | 306590 | 159028 | 50138756 |
Glomerulonephritis membranous | 26.93 | 9.72 | 24 | 307316 | 519 | 50297265 |
Corneal leukoma | 26.90 | 9.72 | 8 | 307332 | 9 | 50297775 |
Protein-losing gastroenteropathy | 26.69 | 9.72 | 16 | 307324 | 181 | 50297603 |
Palatal oedema | 26.62 | 9.72 | 22 | 307318 | 428 | 50297356 |
Brain empyema | 26.29 | 9.72 | 7 | 307333 | 3 | 50297781 |
Constipation | 26.21 | 9.72 | 894 | 306446 | 184814 | 50112970 |
Thyroid disorder | 26.21 | 9.72 | 23 | 307317 | 12654 | 50285130 |
Myelosuppression | 26.20 | 9.72 | 26 | 307314 | 13491 | 50284293 |
Pericarditis | 26.05 | 9.72 | 644 | 306696 | 78045 | 50219739 |
Cytokine release syndrome | 25.87 | 9.72 | 10 | 307330 | 8624 | 50289160 |
Cerebrovascular accident | 25.71 | 9.72 | 412 | 306928 | 94268 | 50203516 |
Distichiasis | 25.62 | 9.72 | 8 | 307332 | 12 | 50297772 |
Cholecystitis | 25.62 | 9.72 | 158 | 307182 | 13713 | 50284071 |
Unevaluable event | 25.60 | 9.72 | 169 | 307171 | 45897 | 50251887 |
Rheumatoid nodule | 25.40 | 9.72 | 148 | 307192 | 12587 | 50285197 |
Posterior reversible encephalopathy syndrome | 25.34 | 9.72 | 32 | 307308 | 14896 | 50282888 |
Drug-induced liver injury | 25.02 | 9.72 | 271 | 307069 | 27824 | 50269960 |
Multiple sclerosis relapse | 24.94 | 9.72 | 383 | 306957 | 42581 | 50255203 |
Systemic lupus erythematosus | 24.78 | 9.72 | 657 | 306683 | 139965 | 50157819 |
Tonsillar erythema | 24.66 | 9.72 | 6 | 307334 | 0 | 50297784 |
Genital odour | 24.66 | 9.72 | 6 | 307334 | 0 | 50297784 |
Blood parathyroid hormone decreased | 24.66 | 9.72 | 97 | 307243 | 7017 | 50290767 |
Blood magnesium decreased | 24.62 | 9.72 | 19 | 307321 | 11141 | 50286643 |
Hunger | 24.53 | 9.72 | 69 | 307271 | 4194 | 50293590 |
Infected dermal cyst | 24.39 | 9.72 | 21 | 307319 | 433 | 50297351 |
Toxic shock syndrome streptococcal | 24.30 | 9.72 | 12 | 307328 | 89 | 50297695 |
Medical device pain | 24.21 | 9.72 | 37 | 307303 | 1450 | 50296334 |
Hepatic function abnormal | 24.17 | 9.72 | 109 | 307231 | 32572 | 50265212 |
Haematochezia | 24.11 | 9.72 | 358 | 306982 | 39524 | 50258260 |
Psychological trauma | 23.99 | 9.72 | 30 | 307310 | 970 | 50296814 |
Cardiac failure acute | 23.99 | 9.72 | 10 | 307330 | 8240 | 50289544 |
Heart rate decreased | 23.94 | 9.72 | 127 | 307213 | 36370 | 50261414 |
Knee arthroplasty | 23.92 | 9.72 | 124 | 307216 | 35722 | 50262062 |
Pneumonia viral | 23.90 | 9.72 | 6 | 307334 | 6828 | 50290956 |
Serum sickness-like reaction | 23.73 | 9.72 | 21 | 307319 | 450 | 50297334 |
Pulmonary fibrosis | 23.63 | 9.72 | 73 | 307267 | 24364 | 50273420 |
Laryngeal discomfort | 23.62 | 9.72 | 17 | 307323 | 267 | 50297517 |
Hypertension | 23.62 | 9.72 | 1045 | 306295 | 210158 | 50087626 |
Cataract | 23.61 | 9.72 | 179 | 307161 | 47121 | 50250663 |
Arthralgia | 23.59 | 9.72 | 3025 | 304315 | 435677 | 49862107 |
Dysmenorrhoea | 23.56 | 9.72 | 58 | 307282 | 3252 | 50294532 |
Back pain | 23.50 | 9.72 | 1594 | 305746 | 218436 | 50079348 |
Ductus arteriosus stenosis foetal | 23.46 | 9.72 | 14 | 307326 | 157 | 50297627 |
Cytopenia | 23.41 | 9.72 | 12 | 307328 | 8763 | 50289021 |
Bronchiectasis | 23.34 | 9.72 | 17 | 307323 | 10266 | 50287518 |
Tumour lysis syndrome | 23.24 | 9.72 | 8 | 307332 | 7413 | 50290371 |
Genital haemorrhage | 23.08 | 9.72 | 90 | 307250 | 6484 | 50291300 |
Kidney enlargement | 23.02 | 9.72 | 22 | 307318 | 522 | 50297262 |
Pneumonia streptococcal | 23.00 | 9.72 | 38 | 307302 | 1593 | 50296191 |
Full blood count decreased | 22.87 | 9.72 | 65 | 307275 | 22281 | 50275503 |
Embolism arterial | 22.76 | 9.72 | 27 | 307313 | 826 | 50296958 |
Scar | 22.70 | 9.72 | 136 | 307204 | 11682 | 50286102 |
Torsade de pointes | 22.67 | 9.72 | 23 | 307317 | 11812 | 50285972 |
Blood glucose increased | 22.63 | 9.72 | 301 | 307039 | 71023 | 50226761 |
Chondritis | 22.62 | 9.72 | 7 | 307333 | 10 | 50297774 |
Red blood cell count decreased | 22.61 | 9.72 | 117 | 307223 | 33718 | 50264066 |
Panniculitis | 22.60 | 9.72 | 107 | 307233 | 8396 | 50289388 |
Cerebral venous sinus thrombosis | 22.37 | 9.72 | 38 | 307302 | 1630 | 50296154 |
Drug level decreased | 22.35 | 9.72 | 6 | 307334 | 6527 | 50291257 |
Underdose | 22.25 | 9.72 | 57 | 307283 | 20221 | 50277563 |
Jaundice | 22.19 | 9.72 | 252 | 307088 | 26177 | 50271607 |
Pathogen resistance | 21.93 | 9.72 | 4 | 307336 | 5685 | 50292099 |
Cholecystectomy | 21.83 | 9.72 | 113 | 307227 | 9190 | 50288594 |
Genital tract inflammation | 21.70 | 9.72 | 8 | 307332 | 25 | 50297759 |
Discomfort | 21.67 | 9.72 | 834 | 306506 | 107546 | 50190238 |
Disease recurrence | 21.61 | 9.72 | 57 | 307283 | 20024 | 50277760 |
Fear of disease | 21.55 | 9.72 | 27 | 307313 | 875 | 50296909 |
Granuloma skin | 21.54 | 9.72 | 81 | 307259 | 5737 | 50292047 |
Nasal disorder | 21.51 | 9.72 | 45 | 307295 | 2263 | 50295521 |
Anaphylactic reaction | 21.50 | 9.72 | 454 | 306886 | 53601 | 50244183 |
Hypertensive emergency | 21.48 | 9.72 | 36 | 307304 | 1527 | 50296257 |
Frequent bowel movements | 21.45 | 9.72 | 32 | 307308 | 13886 | 50283898 |
Internal injury | 21.26 | 9.72 | 17 | 307323 | 315 | 50297469 |
Cushingoid | 21.10 | 9.72 | 7 | 307333 | 6638 | 50291146 |
Beta haemolytic streptococcal infection | 21.07 | 9.72 | 39 | 307301 | 1791 | 50295993 |
Infertility female | 21.05 | 9.72 | 21 | 307319 | 526 | 50297258 |
Fear | 21.04 | 9.72 | 156 | 307184 | 14393 | 50283391 |
Systemic lupus erythematosus rash | 20.97 | 9.72 | 38 | 307302 | 1717 | 50296067 |
Necrosis ischaemic | 20.84 | 9.72 | 25 | 307315 | 774 | 50297010 |
Second primary malignancy | 20.73 | 9.72 | 8 | 307332 | 6906 | 50290878 |
Creatinine renal clearance decreased | 20.66 | 9.72 | 25 | 307315 | 11856 | 50285928 |
Thrombotic microangiopathy | 20.65 | 9.72 | 14 | 307326 | 8777 | 50289007 |
Diabetic ketoacidosis | 20.58 | 9.72 | 49 | 307291 | 17823 | 50279961 |
Viral parotitis | 20.55 | 9.72 | 5 | 307335 | 0 | 50297784 |
Hyperglycaemia | 20.51 | 9.72 | 133 | 307207 | 36272 | 50261512 |
Inappropriate schedule of product administration | 20.37 | 9.72 | 310 | 307030 | 71521 | 50226263 |
Sedation | 20.36 | 9.72 | 106 | 307234 | 30504 | 50267280 |
Aspergillus infection | 20.27 | 9.72 | 8 | 307332 | 6813 | 50290971 |
Extrapyramidal disorder | 20.22 | 9.72 | 25 | 307315 | 11745 | 50286039 |
Metastases to bone | 20.20 | 9.72 | 50 | 307290 | 17945 | 50279839 |
SJS-TEN overlap | 20.17 | 9.72 | 14 | 307326 | 207 | 50297577 |
Progressive multifocal leukoencephalopathy | 20.04 | 9.72 | 24 | 307316 | 11433 | 50286351 |
Enzyme induction | 19.94 | 9.72 | 9 | 307331 | 53 | 50297731 |
Epilepsy | 19.75 | 9.72 | 66 | 307274 | 21501 | 50276283 |
Pericardial effusion | 19.74 | 9.72 | 84 | 307256 | 25505 | 50272279 |
Pemphigus | 19.73 | 9.72 | 567 | 306773 | 119599 | 50178185 |
Breast cancer | 19.71 | 9.72 | 166 | 307174 | 42724 | 50255060 |
Psoriatic arthropathy | 19.69 | 9.72 | 398 | 306942 | 46634 | 50251150 |
Dermo-hypodermitis | 19.67 | 9.72 | 14 | 307326 | 216 | 50297568 |
Pulmonary oedema | 19.63 | 9.72 | 196 | 307144 | 48742 | 50249042 |
Ceruloplasmin decreased | 19.62 | 9.72 | 6 | 307334 | 8 | 50297776 |
Food refusal | 19.59 | 9.72 | 16 | 307324 | 306 | 50297478 |
Renal tubular necrosis | 19.52 | 9.72 | 117 | 307223 | 10051 | 50287733 |
Genital pain | 19.50 | 9.72 | 16 | 307324 | 308 | 50297476 |
Mediastinal abscess | 19.22 | 9.72 | 6 | 307334 | 9 | 50297775 |
Anti-cyclic citrullinated peptide antibody positive | 19.16 | 9.72 | 563 | 306777 | 70024 | 50227760 |
Therapeutic response decreased | 19.01 | 9.72 | 189 | 307151 | 47042 | 50250742 |
Coma scale abnormal | 18.99 | 9.72 | 68 | 307272 | 4703 | 50293081 |
Injection site extravasation | 18.93 | 9.72 | 11 | 307329 | 7490 | 50290294 |
Dyskinesia | 18.81 | 9.72 | 96 | 307244 | 27765 | 50270019 |
Poor venous access | 18.80 | 9.72 | 21 | 307319 | 10319 | 50287465 |
Tinnitus | 18.79 | 9.72 | 257 | 307083 | 27875 | 50269909 |
Metastases to liver | 18.77 | 9.72 | 61 | 307279 | 20043 | 50277741 |
No adverse event | 18.75 | 9.72 | 123 | 307217 | 33455 | 50264329 |
Bacteraemia | 18.75 | 9.72 | 37 | 307303 | 14396 | 50283388 |
Procedural pain | 18.71 | 9.72 | 146 | 307194 | 13686 | 50284098 |
COVID-19 | 18.67 | 9.72 | 187 | 307153 | 46475 | 50251309 |
Staphylococcal infection | 18.63 | 9.72 | 133 | 307207 | 35483 | 50262301 |
Electrocardiogram QRS complex prolonged | 18.63 | 9.72 | 73 | 307267 | 5271 | 50292513 |
Device malfunction | 18.59 | 9.72 | 40 | 307300 | 15081 | 50282703 |
Hepatic necrosis | 18.55 | 9.72 | 72 | 307268 | 5176 | 50292608 |
Full blood count abnormal | 18.52 | 9.72 | 76 | 307264 | 23312 | 50274472 |
Liver disorder | 18.51 | 9.72 | 141 | 307199 | 37081 | 50260703 |
Perichondritis | 18.50 | 9.72 | 7 | 307333 | 24 | 50297760 |
Skin papilloma | 18.33 | 9.72 | 62 | 307278 | 4167 | 50293617 |
Electrocardiogram U-wave abnormality | 18.28 | 9.72 | 7 | 307333 | 25 | 50297759 |
Effusion | 18.26 | 9.72 | 34 | 307306 | 1569 | 50296215 |
Blood pressure fluctuation | 18.15 | 9.72 | 135 | 307205 | 35688 | 50262096 |
Drug abuse | 18.11 | 9.72 | 484 | 306856 | 59362 | 50238422 |
Ulcer | 18.06 | 9.72 | 195 | 307145 | 20005 | 50277779 |
Loss of personal independence in daily activities | 17.97 | 9.72 | 308 | 307032 | 69742 | 50228042 |
Necrotising fasciitis | 17.87 | 9.72 | 45 | 307295 | 2559 | 50295225 |
Labelled drug-food interaction medication error | 17.87 | 9.72 | 7 | 307333 | 27 | 50297757 |
Acute pulmonary oedema | 17.85 | 9.72 | 11 | 307329 | 7256 | 50290528 |
Muscle rigidity | 17.83 | 9.72 | 20 | 307320 | 9809 | 50287975 |
Flushing | 17.73 | 9.72 | 293 | 307047 | 66722 | 50231062 |
Intestinal diaphragm disease | 17.73 | 9.72 | 10 | 307330 | 100 | 50297684 |
Brain injury | 17.71 | 9.72 | 78 | 307262 | 5936 | 50291848 |
Balance disorder | 17.59 | 9.72 | 312 | 307028 | 70278 | 50227506 |
Acute haemorrhagic oedema of infancy | 17.52 | 9.72 | 6 | 307334 | 14 | 50297770 |
Dyspareunia | 17.48 | 9.72 | 40 | 307300 | 2139 | 50295645 |
Hypothermia | 17.47 | 9.72 | 129 | 307211 | 11887 | 50285897 |
Lung neoplasm malignant | 17.40 | 9.72 | 43 | 307297 | 15441 | 50282343 |
Hepatic cirrhosis | 17.35 | 9.72 | 52 | 307288 | 17525 | 50280259 |
Blood pressure decreased | 17.35 | 9.72 | 237 | 307103 | 55672 | 50242112 |
Ludwig angina | 17.34 | 9.72 | 8 | 307332 | 50 | 50297734 |
Osteonecrosis | 17.32 | 9.72 | 74 | 307266 | 22443 | 50275341 |
Glaucoma | 17.28 | 9.72 | 44 | 307296 | 15642 | 50282142 |
Osteonecrosis of jaw | 17.24 | 9.72 | 121 | 307219 | 32405 | 50265379 |
Myoclonus | 17.20 | 9.72 | 39 | 307301 | 14431 | 50283353 |
Tendon disorder | 17.20 | 9.72 | 71 | 307269 | 5251 | 50292533 |
Deafness | 17.19 | 9.72 | 158 | 307182 | 15533 | 50282251 |
Parkinsonism | 17.17 | 9.72 | 17 | 307323 | 8830 | 50288954 |
Product use in unapproved indication | 17.16 | 9.72 | 554 | 306786 | 115265 | 50182519 |
Accidental exposure to product by child | 17.11 | 9.72 | 26 | 307314 | 1014 | 50296770 |
Periorbital oedema | 17.10 | 9.72 | 68 | 307272 | 4944 | 50292840 |
Chromaturia | 17.05 | 9.72 | 149 | 307191 | 14441 | 50283343 |
Vulval ulceration | 16.86 | 9.72 | 13 | 307327 | 228 | 50297556 |
Hepatitis acute | 16.85 | 9.72 | 94 | 307246 | 7867 | 50289917 |
Intentional product misuse | 16.84 | 9.72 | 387 | 306953 | 46347 | 50251437 |
Drug withdrawal headache | 16.83 | 9.72 | 8 | 307332 | 54 | 50297730 |
Electrocardiogram QT prolonged | 16.81 | 9.72 | 218 | 307122 | 51668 | 50246116 |
Glomerulonephritis minimal lesion | 16.81 | 9.72 | 13 | 307327 | 229 | 50297555 |
Staphylococcal sepsis | 16.81 | 9.72 | 11 | 307329 | 7025 | 50290759 |
Immunodeficiency | 16.80 | 9.72 | 41 | 307299 | 14787 | 50282997 |
Cardiotoxicity | 16.77 | 9.72 | 11 | 307329 | 7016 | 50290768 |
Swelling face | 16.68 | 9.72 | 428 | 306912 | 52167 | 50245617 |
Superior sagittal sinus thrombosis | 16.63 | 9.72 | 21 | 307319 | 686 | 50297098 |
Uterine leiomyoma | 16.58 | 9.72 | 93 | 307247 | 7798 | 50289986 |
Tardive dyskinesia | 16.56 | 9.72 | 12 | 307328 | 7267 | 50290517 |
Posthaemorrhagic hydrocephalus | 16.45 | 9.72 | 6 | 307334 | 18 | 50297766 |
Shoulder injury related to vaccine administration | 16.44 | 9.72 | 4 | 307336 | 0 | 50297784 |
Photophobia | 16.36 | 9.72 | 150 | 307190 | 14737 | 50283047 |
Trichiasis | 16.35 | 9.72 | 8 | 307332 | 58 | 50297726 |
Diffuse large B-cell lymphoma | 16.25 | 9.72 | 7 | 307333 | 5655 | 50292129 |
Aplasia pure red cell | 16.17 | 9.72 | 3 | 307337 | 4212 | 50293572 |
Erosive duodenitis | 16.16 | 9.72 | 16 | 307324 | 397 | 50297387 |
Muscle tone disorder | 16.11 | 9.72 | 10 | 307330 | 121 | 50297663 |
Spinal compression fracture | 15.96 | 9.72 | 33 | 307307 | 12623 | 50285161 |
Mania | 15.96 | 9.72 | 26 | 307314 | 10890 | 50286894 |
Pulmonary mass | 15.95 | 9.72 | 59 | 307281 | 18646 | 50279138 |
Anal haemorrhage | 15.78 | 9.72 | 33 | 307307 | 1659 | 50296125 |
Oesophageal discomfort | 15.77 | 9.72 | 11 | 307329 | 164 | 50297620 |
Hepatic infiltration eosinophilic | 15.76 | 9.72 | 6 | 307334 | 21 | 50297763 |
Pituitary tumour benign | 15.76 | 9.72 | 34 | 307306 | 1747 | 50296037 |
Obstructive airways disorder | 15.67 | 9.72 | 46 | 307294 | 15606 | 50282178 |
Cerebral haemorrhage | 15.67 | 9.72 | 98 | 307242 | 26954 | 50270830 |
Tremor neonatal | 15.62 | 9.72 | 9 | 307331 | 94 | 50297690 |
Psychogenic tremor | 15.55 | 9.72 | 6 | 307334 | 22 | 50297762 |
Alanine aminotransferase abnormal | 15.50 | 9.72 | 58 | 307282 | 4098 | 50293686 |
Blood pressure systolic increased | 15.49 | 9.72 | 139 | 307201 | 35310 | 50262474 |
Blood copper decreased | 15.46 | 9.72 | 5 | 307335 | 9 | 50297775 |
Small intestinal stenosis | 15.43 | 9.72 | 17 | 307323 | 479 | 50297305 |
Depression | 15.35 | 9.72 | 1185 | 306155 | 164238 | 50133546 |
Pancreatitis acute | 15.28 | 9.72 | 216 | 307124 | 23596 | 50274188 |
Myopathy | 15.09 | 9.72 | 20 | 307320 | 9119 | 50288665 |
Anoxia | 15.07 | 9.72 | 12 | 307328 | 221 | 50297563 |
Paraesthesia | 15.00 | 9.72 | 883 | 306457 | 119360 | 50178424 |
Nodule | 14.92 | 9.72 | 53 | 307287 | 16950 | 50280834 |
Evans syndrome | 14.90 | 9.72 | 11 | 307329 | 180 | 50297604 |
Hypogammaglobulinaemia | 14.90 | 9.72 | 8 | 307332 | 5691 | 50292093 |
Therapy partial responder | 14.82 | 9.72 | 11 | 307329 | 6580 | 50291204 |
Normochromic anaemia | 14.79 | 9.72 | 13 | 307327 | 276 | 50297508 |
Abdominal tenderness | 14.77 | 9.72 | 85 | 307255 | 7195 | 50290589 |
Injection site hyperaesthesia | 14.75 | 9.72 | 7 | 307333 | 47 | 50297737 |
Laryngeal dyspnoea | 14.63 | 9.72 | 10 | 307330 | 144 | 50297640 |
Schizophrenia | 14.60 | 9.72 | 14 | 307326 | 7383 | 50290401 |
Hypertonia neonatal | 14.58 | 9.72 | 12 | 307328 | 232 | 50297552 |
Urogenital haemorrhage | 14.58 | 9.72 | 12 | 307328 | 232 | 50297552 |
Allergy test positive | 14.58 | 9.72 | 15 | 307325 | 390 | 50297394 |
Cystitis | 14.52 | 9.72 | 187 | 307153 | 44377 | 50253407 |
Thrombophlebitis septic | 14.51 | 9.72 | 10 | 307330 | 146 | 50297638 |
Left ventricular dysfunction | 14.47 | 9.72 | 26 | 307314 | 10480 | 50287304 |
Blood potassium increased | 14.46 | 9.72 | 51 | 307289 | 16347 | 50281437 |
Abnormal loss of weight | 14.40 | 9.72 | 65 | 307275 | 4999 | 50292785 |
Haematotoxicity | 14.39 | 9.72 | 16 | 307324 | 7879 | 50289905 |
Stress cardiomyopathy | 14.36 | 9.72 | 16 | 307324 | 7871 | 50289913 |
Hyperventilation | 14.33 | 9.72 | 68 | 307272 | 5341 | 50292443 |
Temperature regulation disorder | 14.24 | 9.72 | 4 | 307336 | 4223 | 50293561 |
Salivary gland cyst | 14.22 | 9.72 | 4 | 307336 | 3 | 50297781 |
Chemical burn | 14.15 | 9.72 | 14 | 307326 | 347 | 50297437 |
Drug intolerance | 14.12 | 9.72 | 1142 | 306198 | 217962 | 50079822 |
Neonatal hypoxia | 14.08 | 9.72 | 16 | 307324 | 467 | 50297317 |
Bunion operation | 14.07 | 9.72 | 25 | 307315 | 1112 | 50296672 |
Anion gap | 14.07 | 9.72 | 25 | 307315 | 1112 | 50296672 |
Congestive cardiomyopathy | 14.05 | 9.72 | 8 | 307332 | 5510 | 50292274 |
Acquired haemophilia | 14.05 | 9.72 | 22 | 307318 | 881 | 50296903 |
Hypoxia | 14.03 | 9.72 | 222 | 307118 | 50901 | 50246883 |
Gastric infection | 13.98 | 9.72 | 45 | 307295 | 2947 | 50294837 |
Visual snow syndrome | 13.96 | 9.72 | 5 | 307335 | 14 | 50297770 |
Duodenal ulcer repair | 13.94 | 9.72 | 7 | 307333 | 54 | 50297730 |
Blood glucose decreased | 13.91 | 9.72 | 60 | 307280 | 18151 | 50279633 |
Allodynia | 13.87 | 9.72 | 19 | 307321 | 673 | 50297111 |
Alanine aminotransferase increased | 13.86 | 9.72 | 663 | 306677 | 87696 | 50210088 |
Staphylococcal scalded skin syndrome | 13.82 | 9.72 | 9 | 307331 | 119 | 50297665 |
Influenza | 13.82 | 9.72 | 426 | 306914 | 89112 | 50208672 |
Prescribed underdose | 13.80 | 9.72 | 50 | 307290 | 15899 | 50281885 |
Neoplasm progression | 13.78 | 9.72 | 112 | 307228 | 29045 | 50268739 |
Substance abuser | 13.71 | 9.72 | 5 | 307335 | 15 | 50297769 |
Vulvovaginitis trichomonal | 13.71 | 9.72 | 5 | 307335 | 15 | 50297769 |
Urosepsis | 13.71 | 9.72 | 48 | 307292 | 15417 | 50282367 |
Upper gastrointestinal perforation | 13.69 | 9.72 | 4 | 307336 | 4 | 50297780 |
Scleroderma | 13.67 | 9.72 | 6 | 307334 | 4795 | 50292989 |
Pregnancy with contraceptive device | 13.64 | 9.72 | 55 | 307285 | 4024 | 50293760 |
Asphyxia | 13.63 | 9.72 | 8 | 307332 | 5419 | 50292365 |
Diabetes mellitus inadequate control | 13.63 | 9.72 | 38 | 307302 | 13107 | 50284677 |
Splenic vein thrombosis | 13.62 | 9.72 | 13 | 307327 | 308 | 50297476 |
Swollen tongue | 13.59 | 9.72 | 247 | 307093 | 28383 | 50269401 |
Acute myocardial infarction | 13.58 | 9.72 | 113 | 307227 | 29160 | 50268624 |
Fear of injection | 13.55 | 9.72 | 73 | 307267 | 6030 | 50291754 |
Suicidal ideation | 13.50 | 9.72 | 436 | 306904 | 54949 | 50242835 |
Tachycardia | 13.49 | 9.72 | 738 | 306602 | 99025 | 50198759 |
Alveolar rhabdomyosarcoma | 13.47 | 9.72 | 5 | 307335 | 16 | 50297768 |
Total bile acids increased | 13.44 | 9.72 | 9 | 307331 | 125 | 50297659 |
Oral candidiasis | 13.37 | 9.72 | 55 | 307285 | 16860 | 50280924 |
Respiratory tract infection | 13.36 | 9.72 | 127 | 307213 | 31890 | 50265894 |
Allergic respiratory disease | 13.34 | 9.72 | 6 | 307334 | 35 | 50297749 |
Throat tightness | 13.34 | 9.72 | 189 | 307151 | 20658 | 50277126 |
Pneumoperitoneum | 13.32 | 9.72 | 26 | 307314 | 1243 | 50296541 |
Intestinal cyst | 13.31 | 9.72 | 8 | 307332 | 91 | 50297693 |
Renal failure | 13.30 | 9.72 | 521 | 306819 | 106112 | 50191672 |
Abortion spontaneous | 13.26 | 9.72 | 340 | 307000 | 41432 | 50256352 |
Alpha 1 microglobulin increased | 13.23 | 9.72 | 7 | 307333 | 61 | 50297723 |
Hyperuricaemia | 13.09 | 9.72 | 6 | 307334 | 4674 | 50293110 |
Small intestine ulcer | 13.08 | 9.72 | 13 | 307327 | 324 | 50297460 |
Hyperchromic anaemia | 13.07 | 9.72 | 6 | 307334 | 37 | 50297747 |
Blood creatine phosphokinase increased | 13.06 | 9.72 | 100 | 307240 | 26267 | 50271517 |
Henoch-Schonlein purpura nephritis | 13.03 | 9.72 | 5 | 307335 | 18 | 50297766 |
Cellulitis | 12.93 | 9.72 | 329 | 307011 | 70469 | 50227315 |
Benzodiazepine drug level increased | 12.89 | 9.72 | 10 | 307330 | 177 | 50297607 |
Renal disorder | 12.84 | 9.72 | 106 | 307234 | 27399 | 50270385 |
Pulmonary valve disease | 12.82 | 9.72 | 5 | 307335 | 19 | 50297765 |
pH body fluid decreased | 12.82 | 9.72 | 5 | 307335 | 19 | 50297765 |
Lice infestation | 12.81 | 9.72 | 4 | 307336 | 6 | 50297778 |
Pasteurella infection | 12.76 | 9.72 | 7 | 307333 | 66 | 50297718 |
Therapy interrupted | 12.73 | 9.72 | 71 | 307269 | 20081 | 50277703 |
Skin necrosis | 12.71 | 9.72 | 111 | 307229 | 10756 | 50287028 |
Hyperlactacidaemia | 12.67 | 9.72 | 38 | 307302 | 2395 | 50295389 |
Cerebral infarction | 12.65 | 9.72 | 78 | 307262 | 21526 | 50276258 |
Nuchal rigidity | 12.63 | 9.72 | 17 | 307323 | 592 | 50297192 |
Foetal exposure during pregnancy | 12.52 | 9.72 | 106 | 307234 | 27253 | 50270531 |
Erythema multiforme | 12.50 | 9.72 | 96 | 307244 | 8954 | 50288830 |
Anti-thyroid antibody positive | 12.50 | 9.72 | 14 | 307326 | 402 | 50297382 |
Deformity | 12.49 | 9.72 | 18 | 307322 | 7922 | 50289862 |
Papillitis | 12.43 | 9.72 | 5 | 307335 | 21 | 50297763 |
Neuroleptic malignant syndrome | 12.43 | 9.72 | 31 | 307309 | 11099 | 50286685 |
Treatment noncompliance | 12.41 | 9.72 | 120 | 307220 | 30030 | 50267754 |
Pseudomonas infection | 12.40 | 9.72 | 24 | 307316 | 9406 | 50288378 |
Left ventricular failure | 12.36 | 9.72 | 7 | 307333 | 4834 | 50292950 |
Rash maculo-papular | 12.35 | 9.72 | 229 | 307111 | 26412 | 50271372 |
Gastric ulcer haemorrhage | 12.34 | 9.72 | 57 | 307283 | 4427 | 50293357 |
Uraemic gastropathy | 12.33 | 9.72 | 3 | 307337 | 0 | 50297784 |
Corrosive gastritis | 12.33 | 9.72 | 3 | 307337 | 0 | 50297784 |
Ultrasound antenatal screen | 12.33 | 9.72 | 3 | 307337 | 0 | 50297784 |
Anastomotic ulcer perforation | 12.33 | 9.72 | 3 | 307337 | 0 | 50297784 |
Laryngeal web | 12.33 | 9.72 | 3 | 307337 | 0 | 50297784 |
Microsleep | 12.33 | 9.72 | 3 | 307337 | 0 | 50297784 |
Foetal non-stress test | 12.33 | 9.72 | 3 | 307337 | 0 | 50297784 |
Autoimmune hepatitis | 12.26 | 9.72 | 83 | 307257 | 7436 | 50290348 |
Monoplegia | 12.24 | 9.72 | 41 | 307299 | 2742 | 50295042 |
Polymenorrhagia | 12.21 | 9.72 | 6 | 307334 | 44 | 50297740 |
Chest wall abscess | 12.21 | 9.72 | 6 | 307334 | 44 | 50297740 |
Listless | 12.14 | 9.72 | 37 | 307303 | 2353 | 50295431 |
Substance dependence | 12.12 | 9.72 | 10 | 307330 | 194 | 50297590 |
Disturbance in attention | 12.10 | 9.72 | 261 | 307079 | 30925 | 50266859 |
Medication error | 12.10 | 9.72 | 296 | 307044 | 35808 | 50261976 |
Narrow anterior chamber angle | 12.09 | 9.72 | 6 | 307334 | 45 | 50297739 |
Metastases to lung | 12.07 | 9.72 | 31 | 307309 | 10989 | 50286795 |
Vulval disorder | 12.03 | 9.72 | 18 | 307322 | 692 | 50297092 |
Systemic mastocytosis | 12.01 | 9.72 | 9 | 307331 | 151 | 50297633 |
Base excess | 12.00 | 9.72 | 7 | 307333 | 75 | 50297709 |
Facial spasm | 11.99 | 9.72 | 17 | 307323 | 622 | 50297162 |
Xanthoma | 11.98 | 9.72 | 6 | 307334 | 46 | 50297738 |
Dystonia | 11.98 | 9.72 | 35 | 307305 | 11891 | 50285893 |
Carotid artery dissection | 11.96 | 9.72 | 9 | 307331 | 152 | 50297632 |
Haemorrhage intracranial | 11.94 | 9.72 | 37 | 307303 | 12337 | 50285447 |
Abscess rupture | 11.90 | 9.72 | 11 | 307329 | 250 | 50297534 |
Duodenogastric reflux | 11.87 | 9.72 | 6 | 307334 | 47 | 50297737 |
Hyperkalaemia | 11.83 | 9.72 | 213 | 307127 | 47876 | 50249908 |
Escherichia infection | 11.82 | 9.72 | 31 | 307309 | 10910 | 50286874 |
Product administered to patient of inappropriate age | 11.79 | 9.72 | 39 | 307301 | 2591 | 50295193 |
Abnormal clotting factor | 11.78 | 9.72 | 8 | 307332 | 114 | 50297670 |
Rales | 11.77 | 9.72 | 27 | 307313 | 9951 | 50287833 |
Thyroid stimulating immunoglobulin increased | 11.77 | 9.72 | 7 | 307333 | 78 | 50297706 |
Device leakage | 11.75 | 9.72 | 11 | 307329 | 5867 | 50291917 |
Strawberry tongue | 11.74 | 9.72 | 5 | 307335 | 25 | 50297759 |
Drug interaction | 11.73 | 9.72 | 1048 | 306292 | 198573 | 50099211 |
Acidosis | 11.72 | 9.72 | 104 | 307236 | 10123 | 50287661 |
Upper limb fracture | 11.70 | 9.72 | 53 | 307287 | 15820 | 50281964 |
Necrotising colitis | 11.64 | 9.72 | 15 | 307325 | 500 | 50297284 |
Helicobacter test positive | 11.64 | 9.72 | 13 | 307327 | 372 | 50297412 |
Psychotic disorder | 11.63 | 9.72 | 81 | 307259 | 21731 | 50276053 |
Grief reaction | 11.62 | 9.72 | 10 | 307330 | 206 | 50297578 |
Coagulopathy | 11.61 | 9.72 | 163 | 307177 | 17781 | 50280003 |
Blood pressure systolic abnormal | 11.60 | 9.72 | 18 | 307322 | 7688 | 50290096 |
Platelet aggregation decreased | 11.59 | 9.72 | 5 | 307335 | 26 | 50297758 |
Catheterisation cardiac | 11.58 | 9.72 | 5 | 307335 | 4035 | 50293749 |
Cystitis haemorrhagic | 11.58 | 9.72 | 4 | 307336 | 3698 | 50294086 |
Ventricular tachycardia | 11.56 | 9.72 | 53 | 307287 | 15768 | 50282016 |
Glomerulonephropathy | 11.54 | 9.72 | 7 | 307333 | 81 | 50297703 |
Peritonitis bacterial | 11.53 | 9.72 | 7 | 307333 | 4654 | 50293130 |
Coeliac disease | 11.51 | 9.72 | 22 | 307318 | 8663 | 50289121 |
Anti-transglutaminase antibody | 11.49 | 9.72 | 4 | 307336 | 10 | 50297774 |
Clostridium difficile colitis | 11.49 | 9.72 | 62 | 307278 | 17680 | 50280104 |
Blood iron abnormal | 11.48 | 9.72 | 3 | 307337 | 3323 | 50294461 |
Product storage error | 11.48 | 9.72 | 37 | 307303 | 12187 | 50285597 |
Spinal fracture | 11.48 | 9.72 | 52 | 307288 | 15521 | 50282263 |
Pulseless electrical activity | 11.45 | 9.72 | 76 | 307264 | 6765 | 50291019 |
Transverse sinus thrombosis | 11.44 | 9.72 | 15 | 307325 | 509 | 50297275 |
Pneumonia fungal | 11.39 | 9.72 | 6 | 307334 | 4314 | 50293470 |
Tuberculosis | 11.33 | 9.72 | 28 | 307312 | 10055 | 50287729 |
Blood pressure diastolic abnormal | 11.31 | 9.72 | 25 | 307315 | 9336 | 50288448 |
Haemoptysis | 11.29 | 9.72 | 100 | 307240 | 25473 | 50272311 |
Product administration error | 11.20 | 9.72 | 175 | 307165 | 19524 | 50278260 |
Sacroiliitis | 11.19 | 9.72 | 38 | 307302 | 2559 | 50295225 |
Lip erythema | 11.10 | 9.72 | 8 | 307332 | 126 | 50297658 |
Oedema genital | 11.07 | 9.72 | 9 | 307331 | 171 | 50297613 |
Disseminated intravascular coagulation | 11.03 | 9.72 | 60 | 307280 | 17075 | 50280709 |
Basal ganglion degeneration | 11.03 | 9.72 | 13 | 307327 | 395 | 50297389 |
Muscle tightness | 11.00 | 9.72 | 103 | 307237 | 10177 | 50287607 |
Blood calcium decreased | 10.99 | 9.72 | 77 | 307263 | 20629 | 50277155 |
Hepatobiliary scan abnormal | 10.99 | 9.72 | 6 | 307334 | 56 | 50297728 |
Malnutrition | 10.99 | 9.72 | 42 | 307298 | 13147 | 50284637 |
Genitourinary symptom | 10.99 | 9.72 | 6 | 307334 | 56 | 50297728 |
Rash pruritic | 10.98 | 9.72 | 374 | 306966 | 47472 | 50250312 |
Orthopnoea | 10.96 | 9.72 | 11 | 307329 | 5678 | 50292106 |
Needle issue | 10.95 | 9.72 | 17 | 307323 | 7258 | 50290526 |
Atrial flutter | 10.93 | 9.72 | 23 | 307317 | 8740 | 50289044 |
Duodenitis | 10.88 | 9.72 | 44 | 307296 | 3224 | 50294560 |
Prothrombin time ratio decreased | 10.82 | 9.72 | 13 | 307327 | 403 | 50297381 |
Disorientation | 10.80 | 9.72 | 151 | 307189 | 35333 | 50262451 |
Fistula | 10.73 | 9.72 | 21 | 307319 | 8197 | 50289587 |
Vertebral artery occlusion | 10.72 | 9.72 | 7 | 307333 | 93 | 50297691 |
Human papilloma virus test positive | 10.70 | 9.72 | 14 | 307326 | 474 | 50297310 |
Accidental exposure to product | 10.70 | 9.72 | 89 | 307251 | 22968 | 50274816 |
Osteoarthritis | 10.68 | 9.72 | 326 | 307014 | 68280 | 50229504 |
Epistaxis | 10.68 | 9.72 | 301 | 307039 | 63653 | 50234131 |
Colon cancer | 10.68 | 9.72 | 23 | 307317 | 8668 | 50289116 |
Skin cancer | 10.62 | 9.72 | 26 | 307314 | 9368 | 50288416 |
Hip arthroplasty | 10.55 | 9.72 | 126 | 307214 | 30303 | 50267481 |
Lung disorder | 10.53 | 9.72 | 200 | 307140 | 44599 | 50253185 |
Product communication issue | 10.46 | 9.72 | 12 | 307328 | 354 | 50297430 |
Gait deviation | 10.39 | 9.72 | 6 | 307334 | 63 | 50297721 |
International normalised ratio increased | 10.35 | 9.72 | 192 | 307148 | 42960 | 50254824 |
Coronary artery disease | 10.34 | 9.72 | 123 | 307217 | 29603 | 50268181 |
Forced expiratory volume decreased | 10.32 | 9.72 | 7 | 307333 | 4387 | 50293397 |
Secondary adrenocortical insufficiency | 10.32 | 9.72 | 22 | 307318 | 1121 | 50296663 |
Blindness transient | 10.31 | 9.72 | 43 | 307297 | 3195 | 50294589 |
Peripheral sensory neuropathy | 10.31 | 9.72 | 15 | 307325 | 6576 | 50291208 |
Limbal stem cell deficiency | 10.30 | 9.72 | 4 | 307336 | 15 | 50297769 |
Erythema nodosum | 10.29 | 9.72 | 49 | 307291 | 3854 | 50293930 |
Coma | 10.28 | 9.72 | 433 | 306907 | 56446 | 50241338 |
Pharyngeal lesion | 10.27 | 9.72 | 3 | 307337 | 3 | 50297781 |
Meconium ileus | 10.27 | 9.72 | 3 | 307337 | 3 | 50297781 |
Ejection fraction decreased | 10.26 | 9.72 | 68 | 307272 | 18452 | 50279332 |
Toxic encephalopathy | 10.25 | 9.72 | 11 | 307329 | 5504 | 50292280 |
Faeces discoloured | 10.24 | 9.72 | 146 | 307194 | 15978 | 50281806 |
Asthma | 10.18 | 9.72 | 441 | 306899 | 88896 | 50208888 |
Retroplacental haematoma | 10.15 | 9.72 | 8 | 307332 | 145 | 50297639 |
Epiglottic oedema | 10.13 | 9.72 | 5 | 307335 | 37 | 50297747 |
Gastrointestinal ulcer | 10.13 | 9.72 | 29 | 307311 | 1781 | 50296003 |
Scleral oedema | 10.10 | 9.72 | 4 | 307336 | 16 | 50297768 |
Breath sounds abnormal | 10.10 | 9.72 | 20 | 307320 | 7772 | 50290012 |
Myoglobin urine | 10.10 | 9.72 | 4 | 307336 | 16 | 50297768 |
Quadriparesis | 10.10 | 9.72 | 28 | 307312 | 1688 | 50296096 |
Post cholecystectomy syndrome | 10.07 | 9.72 | 6 | 307334 | 67 | 50297717 |
Atypical femur fracture | 10.06 | 9.72 | 9 | 307331 | 4907 | 50292877 |
Syncope | 10.04 | 9.72 | 517 | 306823 | 102485 | 50195299 |
Glycosylated haemoglobin increased | 10.03 | 9.72 | 32 | 307308 | 10574 | 50287210 |
Pleural fibrosis | 10.01 | 9.72 | 4 | 307336 | 3380 | 50294404 |
Neutropenic sepsis | 9.98 | 9.72 | 48 | 307292 | 14099 | 50283685 |
Atrioventricular block complete | 9.95 | 9.72 | 18 | 307322 | 7237 | 50290547 |
Superficial vein prominence | 9.92 | 9.72 | 6 | 307334 | 69 | 50297715 |
Bladder irritation | 9.86 | 9.72 | 9 | 307331 | 201 | 50297583 |
Mallory-Weiss syndrome | 9.86 | 9.72 | 24 | 307316 | 1336 | 50296448 |
Haemorrhage | 9.85 | 9.72 | 248 | 307092 | 53193 | 50244591 |
Murphy's sign positive | 9.81 | 9.72 | 3 | 307337 | 4 | 50297780 |
Heart rate irregular | 9.79 | 9.72 | 73 | 307267 | 19287 | 50278497 |
Gastrointestinal toxicity | 9.75 | 9.72 | 55 | 307285 | 4622 | 50293162 |
Pelvic adhesions | 9.73 | 9.72 | 11 | 307329 | 319 | 50297465 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 540.45 | 10.22 | 702 | 136318 | 31213 | 29406294 |
Intentional overdose | 371.95 | 10.22 | 652 | 136368 | 37876 | 29399631 |
Haematemesis | 311.36 | 10.22 | 471 | 136549 | 24155 | 29413352 |
Drug hypersensitivity | 301.61 | 10.22 | 845 | 136175 | 67561 | 29369946 |
Suicide attempt | 274.74 | 10.22 | 534 | 136486 | 33576 | 29403931 |
Melaena | 243.71 | 10.22 | 482 | 136538 | 30694 | 29406813 |
Aspirin-exacerbated respiratory disease | 241.65 | 10.22 | 83 | 136937 | 283 | 29437224 |
Death | 218.81 | 10.22 | 832 | 136188 | 341252 | 29096255 |
Urticaria | 218.42 | 10.22 | 652 | 136368 | 54008 | 29383499 |
Febrile neutropenia | 210.35 | 10.22 | 130 | 136890 | 112110 | 29325397 |
Completed suicide | 205.87 | 10.22 | 896 | 136124 | 89350 | 29348157 |
Gastric haemorrhage | 201.85 | 10.22 | 232 | 136788 | 9065 | 29428442 |
Off label use | 189.33 | 10.22 | 736 | 136284 | 300064 | 29137443 |
Gastric ulcer | 184.91 | 10.22 | 274 | 136746 | 13787 | 29423720 |
Tubulointerstitial nephritis | 175.90 | 10.22 | 303 | 136717 | 17340 | 29420167 |
Duodenal ulcer | 173.33 | 10.22 | 214 | 136806 | 9024 | 29428483 |
Lip oedema | 171.30 | 10.22 | 114 | 136906 | 2090 | 29435417 |
Glomerulonephritis minimal lesion | 170.24 | 10.22 | 66 | 136954 | 343 | 29437164 |
Acute kidney injury | 154.46 | 10.22 | 1891 | 135129 | 263376 | 29174131 |
Pneumonia | 152.70 | 10.22 | 866 | 136154 | 319306 | 29118201 |
Upper gastrointestinal haemorrhage | 147.91 | 10.22 | 319 | 136701 | 21595 | 29415912 |
Overdose | 142.24 | 10.22 | 738 | 136282 | 79081 | 29358426 |
Interstitial lung disease | 138.87 | 10.22 | 47 | 136973 | 57671 | 29379836 |
Anaphylactic reaction | 134.75 | 10.22 | 354 | 136666 | 27219 | 29410288 |
Gastrointestinal haemorrhage | 123.27 | 10.22 | 708 | 136312 | 78825 | 29358682 |
Neutropenia | 122.96 | 10.22 | 267 | 136753 | 131444 | 29306063 |
Meningitis aseptic | 116.49 | 10.22 | 93 | 136927 | 2283 | 29435224 |
Gastritis | 115.90 | 10.22 | 270 | 136750 | 19247 | 29418260 |
Platelet count decreased | 115.37 | 10.22 | 192 | 136828 | 104480 | 29333027 |
Duodenal ulcer haemorrhage | 111.37 | 10.22 | 120 | 136900 | 4359 | 29433148 |
Peptic ulcer | 108.67 | 10.22 | 91 | 136929 | 2394 | 29435113 |
Palatal oedema | 107.32 | 10.22 | 57 | 136963 | 674 | 29436833 |
Gastric ulcer perforation | 100.08 | 10.22 | 58 | 136962 | 822 | 29436685 |
Abdominal pain upper | 97.78 | 10.22 | 548 | 136472 | 60445 | 29377062 |
Duodenal ulcer perforation | 96.10 | 10.22 | 69 | 136951 | 1437 | 29436070 |
Cardiac failure | 95.41 | 10.22 | 137 | 136883 | 79150 | 29358357 |
Ankylosing spondylitis | 95.37 | 10.22 | 107 | 136913 | 4069 | 29433438 |
Toxicity to various agents | 93.50 | 10.22 | 1221 | 135799 | 172440 | 29265067 |
Sepsis | 92.07 | 10.22 | 345 | 136675 | 142337 | 29295170 |
Renal papillary necrosis | 81.58 | 10.22 | 30 | 136990 | 131 | 29437376 |
Face oedema | 81.52 | 10.22 | 160 | 136860 | 10123 | 29427384 |
Metabolic acidosis | 79.75 | 10.22 | 366 | 136654 | 37296 | 29400211 |
Cardiac failure congestive | 79.32 | 10.22 | 146 | 136874 | 76435 | 29361072 |
Enthesopathy | 78.88 | 10.22 | 92 | 136928 | 3651 | 29433856 |
Eyelid oedema | 78.41 | 10.22 | 102 | 136918 | 4534 | 29432973 |
Wound closure | 77.68 | 10.22 | 24 | 136996 | 52 | 29437455 |
Pancytopenia | 77.21 | 10.22 | 169 | 136851 | 82999 | 29354508 |
Gastric ulcer haemorrhage | 76.78 | 10.22 | 104 | 136916 | 4810 | 29432697 |
Osteotomy | 76.47 | 10.22 | 24 | 136996 | 56 | 29437451 |
Stevens-Johnson syndrome | 73.75 | 10.22 | 205 | 136815 | 16292 | 29421215 |
Intentional product misuse | 72.76 | 10.22 | 336 | 136684 | 34325 | 29403182 |
Peritonsillar abscess | 72.70 | 10.22 | 34 | 136986 | 299 | 29437208 |
Thrombocytopenia | 71.03 | 10.22 | 352 | 136668 | 134471 | 29303036 |
Gastritis erosive | 67.90 | 10.22 | 103 | 136917 | 5290 | 29432217 |
Cytomegalovirus infection | 67.12 | 10.22 | 13 | 137007 | 23202 | 29414305 |
Headache | 64.75 | 10.22 | 1149 | 135871 | 172858 | 29264649 |
Vomiting | 64.54 | 10.22 | 1359 | 135661 | 210901 | 29226606 |
Psoriatic arthropathy | 64.14 | 10.22 | 181 | 136839 | 14510 | 29422997 |
Renal tubular acidosis | 62.75 | 10.22 | 58 | 136962 | 1745 | 29435762 |
Nasal obstruction | 61.70 | 10.22 | 36 | 136984 | 517 | 29436990 |
Self-medication | 61.24 | 10.22 | 62 | 136958 | 2092 | 29435415 |
Glomerulonephritis membranous | 60.84 | 10.22 | 44 | 136976 | 927 | 29436580 |
Tongue oedema | 60.75 | 10.22 | 67 | 136953 | 2499 | 29435008 |
Hypersensitivity | 60.36 | 10.22 | 436 | 136584 | 52467 | 29385040 |
Intestinal diaphragm disease | 59.29 | 10.22 | 27 | 136993 | 222 | 29437285 |
Disease progression | 58.89 | 10.22 | 189 | 136831 | 81727 | 29355780 |
Malignant neoplasm progression | 58.43 | 10.22 | 163 | 136857 | 73696 | 29363811 |
Drug resistance | 58.33 | 10.22 | 14 | 137006 | 21526 | 29415981 |
Tenosynovitis | 58.31 | 10.22 | 79 | 136941 | 3654 | 29433853 |
Hepatic function abnormal | 56.52 | 10.22 | 59 | 136961 | 39200 | 29398307 |
White blood cell count decreased | 54.73 | 10.22 | 200 | 136820 | 83162 | 29354345 |
Lip swelling | 53.30 | 10.22 | 152 | 136868 | 12258 | 29425249 |
Faeces discoloured | 53.00 | 10.22 | 159 | 136861 | 13192 | 29424315 |
Suspected suicide | 52.35 | 10.22 | 78 | 136942 | 3942 | 29433565 |
Tongue disorder | 50.69 | 10.22 | 83 | 136937 | 4553 | 29432954 |
Swelling face | 50.12 | 10.22 | 207 | 136813 | 20143 | 29417364 |
Septic shock | 49.52 | 10.22 | 138 | 136882 | 62422 | 29375085 |
Tendonitis | 49.31 | 10.22 | 112 | 136908 | 7849 | 29429658 |
Toxic epidermal necrolysis | 48.18 | 10.22 | 189 | 136831 | 17964 | 29419543 |
Ascites | 45.29 | 10.22 | 62 | 136958 | 36557 | 29400950 |
Atrial fibrillation | 45.23 | 10.22 | 295 | 136725 | 105351 | 29332156 |
Pyloric stenosis | 44.76 | 10.22 | 33 | 136987 | 717 | 29436790 |
Hospitalisation | 44.70 | 10.22 | 91 | 136929 | 45897 | 29391610 |
Hyperhidrosis | 44.43 | 10.22 | 476 | 136544 | 64064 | 29373443 |
Acute hepatic failure | 44.33 | 10.22 | 139 | 136881 | 11813 | 29425694 |
Neutrophil count decreased | 43.38 | 10.22 | 85 | 136935 | 43482 | 29394025 |
Coronavirus infection | 43.11 | 10.22 | 64 | 136956 | 3224 | 29434283 |
Pruritus | 41.42 | 10.22 | 766 | 136254 | 116083 | 29321424 |
Jejunal ulcer perforation | 41.25 | 10.22 | 15 | 137005 | 63 | 29437444 |
Bone marrow failure | 40.93 | 10.22 | 40 | 136980 | 27409 | 29410098 |
Macrocephaly | 40.61 | 10.22 | 25 | 136995 | 398 | 29437109 |
Haematochezia | 40.57 | 10.22 | 302 | 136718 | 36681 | 29400826 |
Conjunctivitis | 40.40 | 10.22 | 104 | 136916 | 7894 | 29429613 |
Encephalopathy | 38.95 | 10.22 | 52 | 136968 | 30991 | 29406516 |
Fixed eruption | 38.64 | 10.22 | 37 | 136983 | 1165 | 29436342 |
Discoloured vomit | 38.39 | 10.22 | 25 | 136995 | 441 | 29437066 |
Erythema multiforme | 37.60 | 10.22 | 99 | 136921 | 7618 | 29429889 |
Pain | 37.59 | 10.22 | 1050 | 135970 | 170382 | 29267125 |
Mast cell activation syndrome | 37.57 | 10.22 | 18 | 137002 | 168 | 29437339 |
Mucocutaneous disorder | 37.44 | 10.22 | 16 | 137004 | 111 | 29437396 |
Hypoglycaemia | 37.26 | 10.22 | 108 | 136912 | 48238 | 29389269 |
Laryngeal dyspnoea | 37.20 | 10.22 | 15 | 137005 | 88 | 29437419 |
Tropical infectious disease | 36.08 | 10.22 | 12 | 137008 | 36 | 29437471 |
Duodenitis | 36.05 | 10.22 | 67 | 136953 | 4068 | 29433439 |
Erosive oesophagitis | 35.96 | 10.22 | 38 | 136982 | 1349 | 29436158 |
Respiratory failure | 35.85 | 10.22 | 283 | 136737 | 96848 | 29340659 |
Hypoxia | 35.67 | 10.22 | 107 | 136913 | 47272 | 29390235 |
Medication overuse headache | 34.51 | 10.22 | 15 | 137005 | 109 | 29437398 |
Graft versus host disease | 33.52 | 10.22 | 3 | 137017 | 9625 | 29427882 |
Neuropathy peripheral | 33.16 | 10.22 | 193 | 136827 | 70834 | 29366673 |
Hypomagnesaemia | 32.99 | 10.22 | 20 | 137000 | 17448 | 29420059 |
Renal cortical necrosis | 32.79 | 10.22 | 16 | 137004 | 156 | 29437351 |
Myocardial infarction | 32.59 | 10.22 | 340 | 136680 | 109956 | 29327551 |
Type I hypersensitivity | 32.59 | 10.22 | 32 | 136988 | 1040 | 29436467 |
Gastritis haemorrhagic | 32.13 | 10.22 | 34 | 136986 | 1209 | 29436298 |
Acute generalised exanthematous pustulosis | 31.79 | 10.22 | 76 | 136944 | 5507 | 29432000 |
Renal tubular necrosis | 31.69 | 10.22 | 141 | 136879 | 14174 | 29423333 |
Pharyngeal abscess | 31.60 | 10.22 | 21 | 136999 | 384 | 29437123 |
Eye swelling | 31.48 | 10.22 | 100 | 136920 | 8557 | 29428950 |
Alanine aminotransferase abnormal | 31.07 | 10.22 | 52 | 136968 | 2905 | 29434602 |
Pneumocystis jirovecii pneumonia | 30.60 | 10.22 | 20 | 137000 | 16759 | 29420748 |
Myelodysplastic syndrome | 30.09 | 10.22 | 23 | 136997 | 17771 | 29419736 |
Musculoskeletal stiffness | 29.97 | 10.22 | 285 | 136735 | 37173 | 29400334 |
Clostridium difficile infection | 29.76 | 10.22 | 19 | 137001 | 16122 | 29421385 |
Cytopenia | 29.62 | 10.22 | 5 | 137015 | 9854 | 29427653 |
Ventricular tachyarrhythmia | 29.60 | 10.22 | 18 | 137002 | 280 | 29437227 |
Blood glucose increased | 29.31 | 10.22 | 157 | 136863 | 58827 | 29378680 |
Cerebral infarction | 29.29 | 10.22 | 43 | 136977 | 24632 | 29412875 |
Muscle swelling | 29.28 | 10.22 | 19 | 137001 | 333 | 29437174 |
Analgesic drug level increased | 28.65 | 10.22 | 23 | 136997 | 569 | 29436938 |
Plasma cell myeloma | 28.53 | 10.22 | 83 | 136937 | 37032 | 29400475 |
Conjunctival hyperaemia | 28.48 | 10.22 | 42 | 136978 | 2103 | 29435404 |
Brain empyema | 28.17 | 10.22 | 7 | 137013 | 3 | 29437504 |
Arthralgia | 27.53 | 10.22 | 844 | 136176 | 138773 | 29298734 |
Diarrhoea | 27.50 | 10.22 | 1261 | 135759 | 331437 | 29106070 |
Poisoning | 27.29 | 10.22 | 105 | 136915 | 9888 | 29427619 |
Full blood count abnormal | 27.23 | 10.22 | 18 | 137002 | 14995 | 29422512 |
Confusional state | 27.05 | 10.22 | 423 | 136597 | 127454 | 29310053 |
Joint swelling | 27.03 | 10.22 | 350 | 136670 | 49280 | 29388227 |
Intervertebral disc protrusion | 26.96 | 10.22 | 95 | 136925 | 8575 | 29428932 |
Milk-alkali syndrome | 26.81 | 10.22 | 21 | 136999 | 501 | 29437006 |
Erysipelas | 26.79 | 10.22 | 60 | 136960 | 4165 | 29433342 |
Periorbital oedema | 26.78 | 10.22 | 52 | 136968 | 3263 | 29434244 |
Bronchopulmonary aspergillosis | 26.46 | 10.22 | 12 | 137008 | 12332 | 29425175 |
Beta haemolytic streptococcal infection | 26.30 | 10.22 | 20 | 137000 | 456 | 29437051 |
Synovitis | 26.20 | 10.22 | 110 | 136910 | 10780 | 29426727 |
C-reactive protein abnormal | 26.09 | 10.22 | 78 | 136942 | 6458 | 29431049 |
Lemierre syndrome | 25.84 | 10.22 | 7 | 137013 | 7 | 29437500 |
Erosive duodenitis | 25.68 | 10.22 | 31 | 136989 | 1276 | 29436231 |
Peptic ulcer perforation | 25.54 | 10.22 | 14 | 137006 | 177 | 29437330 |
Dactylitis | 25.47 | 10.22 | 23 | 136997 | 671 | 29436836 |
Wrong technique in product usage process | 25.10 | 10.22 | 69 | 136951 | 31359 | 29406148 |
Meningitis pneumococcal | 25.06 | 10.22 | 13 | 137007 | 146 | 29437361 |
Tonsillitis | 24.97 | 10.22 | 38 | 136982 | 1957 | 29435550 |
Transplant rejection | 24.91 | 10.22 | 6 | 137014 | 9206 | 29428301 |
Cerebral atrophy congenital | 24.89 | 10.22 | 10 | 137010 | 58 | 29437449 |
Weight increased | 24.87 | 10.22 | 231 | 136789 | 76436 | 29361071 |
Transposition of the great vessels | 24.70 | 10.22 | 19 | 137001 | 441 | 29437066 |
Neuroleptic malignant syndrome | 24.70 | 10.22 | 23 | 136997 | 16125 | 29421382 |
Obstruction gastric | 24.66 | 10.22 | 25 | 136995 | 845 | 29436662 |
Perforated ulcer | 24.53 | 10.22 | 13 | 137007 | 153 | 29437354 |
Swelling of eyelid | 24.43 | 10.22 | 21 | 136999 | 573 | 29436934 |
Drug-induced liver injury | 24.40 | 10.22 | 178 | 136842 | 21477 | 29416030 |
Drug ineffective | 24.37 | 10.22 | 1406 | 135614 | 361764 | 29075743 |
Ulcer | 24.33 | 10.22 | 80 | 136940 | 6971 | 29430536 |
Sacroiliitis | 24.25 | 10.22 | 28 | 136992 | 1099 | 29436408 |
Oral pruritus | 24.03 | 10.22 | 15 | 137005 | 245 | 29437262 |
Dermo-hypodermitis | 23.98 | 10.22 | 15 | 137005 | 246 | 29437261 |
Back pain | 23.95 | 10.22 | 632 | 136388 | 101652 | 29335855 |
Febrile bone marrow aplasia | 23.77 | 10.22 | 3 | 137017 | 7348 | 29430159 |
Intentional product use issue | 23.47 | 10.22 | 109 | 136911 | 42389 | 29395118 |
Multiple sclerosis relapse | 23.44 | 10.22 | 110 | 136910 | 11309 | 29426198 |
Fluid retention | 23.42 | 10.22 | 46 | 136974 | 23514 | 29413993 |
Renal impairment | 23.09 | 10.22 | 253 | 136767 | 81080 | 29356427 |
Tobacco abuse | 22.76 | 10.22 | 17 | 137003 | 377 | 29437130 |
Chronic obstructive pulmonary disease | 22.64 | 10.22 | 105 | 136915 | 40850 | 29396657 |
Vanishing bile duct syndrome | 22.60 | 10.22 | 20 | 137000 | 568 | 29436939 |
Dermatomyositis | 22.49 | 10.22 | 26 | 136994 | 1022 | 29436485 |
Helicobacter test positive | 22.47 | 10.22 | 21 | 136999 | 641 | 29436866 |
Liver injury | 22.32 | 10.22 | 117 | 136903 | 12573 | 29424934 |
Sebaceous gland disorder | 22.14 | 10.22 | 6 | 137014 | 6 | 29437501 |
Red blood cell count decreased | 22.14 | 10.22 | 54 | 136966 | 25548 | 29411959 |
Gastrointestinal injury | 22.09 | 10.22 | 16 | 137004 | 338 | 29437169 |
Prepyloric stenosis | 21.90 | 10.22 | 5 | 137015 | 0 | 29437507 |
Kawasaki's disease | 21.90 | 10.22 | 5 | 137015 | 0 | 29437507 |
Benign familial pemphigus | 21.90 | 10.22 | 5 | 137015 | 0 | 29437507 |
Pulmonary arterial hypertension | 21.90 | 10.22 | 4 | 137016 | 7445 | 29430062 |
Angular cheilitis | 21.74 | 10.22 | 12 | 137008 | 154 | 29437353 |
Lymphocyte count decreased | 21.52 | 10.22 | 35 | 136985 | 19236 | 29418271 |
Migraine | 21.45 | 10.22 | 114 | 136906 | 12316 | 29425191 |
Hypervolaemia | 21.39 | 10.22 | 30 | 136990 | 17515 | 29419992 |
Flank pain | 21.36 | 10.22 | 68 | 136952 | 5825 | 29431682 |
Fractional exhaled nitric oxide increased | 21.22 | 10.22 | 16 | 137004 | 360 | 29437147 |
Macrophages increased | 21.15 | 10.22 | 12 | 137008 | 163 | 29437344 |
Abdominal pain | 21.04 | 10.22 | 796 | 136224 | 134561 | 29302946 |
Oxygen saturation decreased | 21.02 | 10.22 | 122 | 136898 | 44815 | 29392692 |
Anosmia | 20.90 | 10.22 | 35 | 136985 | 1956 | 29435551 |
Hypoaldosteronism | 20.90 | 10.22 | 12 | 137008 | 167 | 29437340 |
Oesophageal rupture | 20.81 | 10.22 | 16 | 137004 | 371 | 29437136 |
Symmetrical drug-related intertriginous and flexural exanthema | 20.64 | 10.22 | 13 | 137007 | 216 | 29437291 |
Pathogen resistance | 20.59 | 10.22 | 6 | 137014 | 8110 | 29429397 |
Heart rate decreased | 20.42 | 10.22 | 54 | 136966 | 24858 | 29412649 |
Nasal disorder | 20.15 | 10.22 | 29 | 136991 | 1420 | 29436087 |
Kidney transplant rejection | 20.08 | 10.22 | 4 | 137016 | 7001 | 29430506 |
Psoriasis | 20.02 | 10.22 | 233 | 136787 | 31994 | 29405513 |
Pulmonary oedema | 20.00 | 10.22 | 116 | 136904 | 42619 | 29394888 |
Ocular icterus | 19.89 | 10.22 | 40 | 136980 | 2575 | 29434932 |
Tumour lysis syndrome | 19.82 | 10.22 | 21 | 136999 | 13863 | 29423644 |
Diabetes mellitus | 19.79 | 10.22 | 106 | 136914 | 39725 | 29397782 |
Secondary amyloidosis | 19.76 | 10.22 | 9 | 137011 | 74 | 29437433 |
Nasal turbinate hypertrophy | 19.66 | 10.22 | 9 | 137011 | 75 | 29437432 |
Hypotension | 19.55 | 10.22 | 720 | 136300 | 193634 | 29243873 |
Cytomegalovirus viraemia | 19.45 | 10.22 | 3 | 137017 | 6317 | 29431190 |
Alcohol use | 19.32 | 10.22 | 44 | 136976 | 3088 | 29434419 |
Streptococcal infection | 19.30 | 10.22 | 55 | 136965 | 4433 | 29433074 |
Post concussion syndrome | 19.22 | 10.22 | 10 | 137010 | 113 | 29437394 |
Anaemia | 19.20 | 10.22 | 749 | 136271 | 200202 | 29237305 |
Erythema | 19.10 | 10.22 | 472 | 136548 | 75134 | 29362373 |
Duodenal obstruction | 19.03 | 10.22 | 11 | 137009 | 155 | 29437352 |
Haemophilia | 18.98 | 10.22 | 5 | 137015 | 4 | 29437503 |
Necrotising soft tissue infection | 18.90 | 10.22 | 8 | 137012 | 54 | 29437453 |
Nausea | 18.87 | 10.22 | 1570 | 135450 | 287685 | 29149822 |
Clostridium difficile colitis | 18.85 | 10.22 | 20 | 137000 | 13192 | 29424315 |
Neutropenic sepsis | 18.78 | 10.22 | 16 | 137004 | 11711 | 29425796 |
Gastrointestinal hypermotility | 18.77 | 10.22 | 10 | 137010 | 119 | 29437388 |
Xyphoid retraction | 18.61 | 10.22 | 11 | 137009 | 162 | 29437345 |
Meningitis streptococcal | 18.61 | 10.22 | 7 | 137013 | 33 | 29437474 |
Epidermolysis | 18.60 | 10.22 | 13 | 137007 | 259 | 29437248 |
Implant site extravasation | 18.49 | 10.22 | 15 | 137005 | 377 | 29437130 |
Atrioventricular block complete | 18.44 | 10.22 | 7 | 137013 | 8004 | 29429503 |
Phonophobia | 18.44 | 10.22 | 11 | 137009 | 165 | 29437342 |
Food intolerance | 18.37 | 10.22 | 24 | 136996 | 1071 | 29436436 |
Plantar fasciitis | 18.35 | 10.22 | 26 | 136994 | 1255 | 29436252 |
Pleural effusion | 18.35 | 10.22 | 229 | 136791 | 71679 | 29365828 |
Pulmonary embolism | 18.32 | 10.22 | 247 | 136773 | 76287 | 29361220 |
Head discomfort | 18.31 | 10.22 | 44 | 136976 | 3198 | 29434309 |
Hepatocellular carcinoma | 18.24 | 10.22 | 5 | 137015 | 7033 | 29430474 |
Acute respiratory failure | 18.21 | 10.22 | 62 | 136958 | 26340 | 29411167 |
Oropharyngeal blistering | 18.15 | 10.22 | 11 | 137009 | 170 | 29437337 |
Otitis media acute | 18.12 | 10.22 | 16 | 137004 | 453 | 29437054 |
Mucosal necrosis | 18.08 | 10.22 | 8 | 137012 | 61 | 29437446 |
Posthaemorrhagic hydrocephalus | 18.08 | 10.22 | 9 | 137011 | 92 | 29437415 |
Intestinal obstruction | 18.01 | 10.22 | 39 | 136981 | 19238 | 29418269 |
Epistaxis | 17.98 | 10.22 | 153 | 136867 | 51551 | 29385956 |
Oesophagitis haemorrhagic | 17.89 | 10.22 | 12 | 137008 | 223 | 29437284 |
Neurotoxicity | 17.80 | 10.22 | 25 | 136995 | 14588 | 29422919 |
Cardiac arrest | 17.79 | 10.22 | 284 | 136736 | 85307 | 29352200 |
Cerebral haemorrhage | 17.71 | 10.22 | 80 | 136940 | 31346 | 29406161 |
Influenza like illness | 17.54 | 10.22 | 182 | 136838 | 24288 | 29413219 |
Tympanic membrane hyperaemia | 17.52 | 10.22 | 4 | 137016 | 0 | 29437507 |
Fall | 17.45 | 10.22 | 658 | 136362 | 176520 | 29260987 |
Intervertebral disc disorder | 17.42 | 10.22 | 30 | 136990 | 1715 | 29435792 |
COVID-19 | 17.26 | 10.22 | 97 | 136923 | 35917 | 29401590 |
Duodenal stenosis | 17.24 | 10.22 | 11 | 137009 | 187 | 29437320 |
Angiocardiogram | 17.14 | 10.22 | 11 | 137009 | 189 | 29437318 |
Cerebrovascular accident | 17.07 | 10.22 | 252 | 136768 | 76659 | 29360848 |
Energy increased | 17.00 | 10.22 | 24 | 136996 | 1154 | 29436353 |
Cardiogenic shock | 16.97 | 10.22 | 40 | 136980 | 19150 | 29418357 |
International normalised ratio increased | 16.95 | 10.22 | 128 | 136892 | 44244 | 29393263 |
Crying | 16.95 | 10.22 | 59 | 136961 | 5292 | 29432215 |
Mallory-Weiss syndrome | 16.95 | 10.22 | 25 | 136995 | 1252 | 29436255 |
Lip erosion | 16.91 | 10.22 | 16 | 137004 | 496 | 29437011 |
Asthenia | 16.90 | 10.22 | 820 | 136200 | 214430 | 29223077 |
Delirium | 16.84 | 10.22 | 110 | 136910 | 39287 | 29398220 |
Acute myeloid leukaemia | 16.62 | 10.22 | 32 | 136988 | 16481 | 29421026 |
Extra dose administered | 16.57 | 10.22 | 41 | 136979 | 3036 | 29434471 |
Herbal interaction | 16.57 | 10.22 | 13 | 137007 | 311 | 29437196 |
Deep vein thrombosis | 16.50 | 10.22 | 178 | 136842 | 57221 | 29380286 |
Transaminases increased | 16.45 | 10.22 | 169 | 136851 | 22493 | 29415014 |
Exostosis | 16.43 | 10.22 | 45 | 136975 | 3544 | 29433963 |
Cytokine release syndrome | 16.43 | 10.22 | 22 | 136998 | 13097 | 29424410 |
Coma scale abnormal | 16.39 | 10.22 | 44 | 136976 | 3425 | 29434082 |
Neoplasm progression | 16.29 | 10.22 | 39 | 136981 | 18573 | 29418934 |
Onychomycosis | 16.24 | 10.22 | 32 | 136988 | 2030 | 29435477 |
Dyspepsia | 16.21 | 10.22 | 212 | 136808 | 29913 | 29407594 |
Intentional self-injury | 16.15 | 10.22 | 106 | 136914 | 12355 | 29425152 |
Gastrointestinal ulcer | 16.13 | 10.22 | 28 | 136992 | 1611 | 29435896 |
Hypothermia | 16.12 | 10.22 | 85 | 136935 | 9154 | 29428353 |
Neck pain | 16.08 | 10.22 | 161 | 136859 | 21286 | 29416221 |
Inadequate analgesia | 16.06 | 10.22 | 37 | 136983 | 2617 | 29434890 |
Congenital skin dimples | 16.04 | 10.22 | 10 | 137010 | 163 | 29437344 |
Post transplant lymphoproliferative disorder | 16.04 | 10.22 | 3 | 137017 | 5490 | 29432017 |
Thrombosis mesenteric vessel | 15.97 | 10.22 | 7 | 137013 | 52 | 29437455 |
Epiglottic oedema | 15.93 | 10.22 | 10 | 137010 | 165 | 29437342 |
Ankle deformity | 15.92 | 10.22 | 11 | 137009 | 215 | 29437292 |
Infection masked | 15.86 | 10.22 | 7 | 137013 | 53 | 29437454 |
Portal vein phlebitis | 15.83 | 10.22 | 5 | 137015 | 12 | 29437495 |
Acquired epidermolysis bullosa | 15.83 | 10.22 | 5 | 137015 | 12 | 29437495 |
Cataract | 15.81 | 10.22 | 52 | 136968 | 22326 | 29415181 |
Cervicobrachial syndrome | 15.80 | 10.22 | 12 | 137008 | 273 | 29437234 |
Incorrect route of product administration | 15.80 | 10.22 | 16 | 137004 | 10785 | 29426722 |
Spinal pain | 15.73 | 10.22 | 54 | 136966 | 4810 | 29432697 |
Superinfection | 15.69 | 10.22 | 31 | 136989 | 1970 | 29435537 |
Skin texture abnormal | 15.66 | 10.22 | 6 | 137014 | 30 | 29437477 |
Urticaria chronic | 15.56 | 10.22 | 8 | 137012 | 88 | 29437419 |
Aortic bruit | 15.48 | 10.22 | 10 | 137010 | 174 | 29437333 |
Hepatitis acute | 15.33 | 10.22 | 65 | 136955 | 6397 | 29431110 |
Subdural abscess | 15.29 | 10.22 | 4 | 137016 | 3 | 29437504 |
Diffuse large B-cell lymphoma | 15.28 | 10.22 | 5 | 137015 | 6271 | 29431236 |
Full blood count decreased | 15.23 | 10.22 | 32 | 136988 | 15960 | 29421547 |
Orthostatic intolerance | 15.18 | 10.22 | 17 | 137003 | 645 | 29436862 |
Haematotoxicity | 15.18 | 10.22 | 6 | 137014 | 6693 | 29430814 |
Hypertensive emergency | 15.09 | 10.22 | 19 | 137001 | 817 | 29436690 |
Progressive multifocal leukoencephalopathy | 15.09 | 10.22 | 11 | 137009 | 8708 | 29428799 |
Peritonitis bacterial | 15.08 | 10.22 | 4 | 137016 | 5752 | 29431755 |
Gastric mucosa erythema | 15.08 | 10.22 | 11 | 137009 | 235 | 29437272 |
Dental operation | 15.05 | 10.22 | 13 | 137007 | 357 | 29437150 |
Carbohydrate antigen 19-9 increased | 15.04 | 10.22 | 10 | 137010 | 183 | 29437324 |
Torsade de pointes | 15.04 | 10.22 | 6 | 137014 | 6655 | 29430852 |
Anterior interosseous syndrome | 15.03 | 10.22 | 5 | 137015 | 15 | 29437492 |
Retinopathy of prematurity | 15.03 | 10.22 | 8 | 137012 | 95 | 29437412 |
Disease recurrence | 15.03 | 10.22 | 32 | 136988 | 15882 | 29421625 |
Gastric perforation | 14.94 | 10.22 | 32 | 136988 | 2154 | 29435353 |
SJS-TEN overlap | 14.84 | 10.22 | 11 | 137009 | 241 | 29437266 |
Eye oedema | 14.81 | 10.22 | 17 | 137003 | 663 | 29436844 |
Blood bilirubin unconjugated | 14.76 | 10.22 | 4 | 137016 | 4 | 29437503 |
Allergy test negative | 14.76 | 10.22 | 4 | 137016 | 4 | 29437503 |
Facet joint syndrome | 14.69 | 10.22 | 11 | 137009 | 245 | 29437262 |
Tongue injury | 14.68 | 10.22 | 8 | 137012 | 100 | 29437407 |
Respiratory fatigue | 14.64 | 10.22 | 7 | 137013 | 65 | 29437442 |
Oesophagitis | 14.60 | 10.22 | 100 | 136920 | 11823 | 29425684 |
Spinal cord infection | 14.58 | 10.22 | 9 | 137011 | 144 | 29437363 |
Bradycardia | 14.57 | 10.22 | 215 | 136805 | 65414 | 29372093 |
Asthma | 14.54 | 10.22 | 229 | 136791 | 33620 | 29403887 |
Gastritis bacterial | 14.45 | 10.22 | 10 | 137010 | 196 | 29437311 |
Musculoskeletal pain | 14.45 | 10.22 | 201 | 136819 | 28752 | 29408755 |
Pruritus genital | 14.37 | 10.22 | 15 | 137005 | 525 | 29436982 |
Pneumonitis | 14.28 | 10.22 | 74 | 136946 | 27970 | 29409537 |
Parkinsonism | 14.21 | 10.22 | 8 | 137012 | 7270 | 29430237 |
Blood pressure fluctuation | 14.21 | 10.22 | 46 | 136974 | 19848 | 29417659 |
Costochondritis | 14.21 | 10.22 | 14 | 137006 | 457 | 29437050 |
Anuria | 14.14 | 10.22 | 84 | 136936 | 9457 | 29428050 |
Hepatitis B | 14.07 | 10.22 | 4 | 137016 | 5493 | 29432014 |
Depression | 14.01 | 10.22 | 504 | 136516 | 84643 | 29352864 |
Photophobia | 13.99 | 10.22 | 60 | 136960 | 5935 | 29431572 |
Lower gastrointestinal haemorrhage | 13.95 | 10.22 | 75 | 136945 | 8138 | 29429369 |
Multiple organ dysfunction syndrome | 13.93 | 10.22 | 207 | 136813 | 62909 | 29374598 |
Paraesthesia oral | 13.92 | 10.22 | 42 | 136978 | 3495 | 29434012 |
Oesophageal infection | 13.88 | 10.22 | 11 | 137009 | 267 | 29437240 |
Microbiology test abnormal | 13.88 | 10.22 | 4 | 137016 | 6 | 29437501 |
Coating in mouth | 13.78 | 10.22 | 7 | 137013 | 75 | 29437432 |
Meningoencephalitis bacterial | 13.77 | 10.22 | 8 | 137012 | 114 | 29437393 |
Purpura fulminans | 13.70 | 10.22 | 7 | 137013 | 76 | 29437431 |
Ulcer haemorrhage | 13.65 | 10.22 | 33 | 136987 | 2408 | 29435099 |
Staphylococcal abscess | 13.63 | 10.22 | 15 | 137005 | 558 | 29436949 |
Asthmatic crisis | 13.61 | 10.22 | 13 | 137007 | 408 | 29437099 |
Right ventricular failure | 13.60 | 10.22 | 10 | 137010 | 7880 | 29429627 |
Exposure to toxic agent | 13.54 | 10.22 | 34 | 136986 | 2541 | 29434966 |
Hyperglycaemia | 13.53 | 10.22 | 98 | 136922 | 34189 | 29403318 |
Conjunctival erosion | 13.50 | 10.22 | 4 | 137016 | 7 | 29437500 |
Osteomyelitis blastomyces | 13.50 | 10.22 | 4 | 137016 | 7 | 29437500 |
Posterior reversible encephalopathy syndrome | 13.47 | 10.22 | 13 | 137007 | 8963 | 29428544 |
Apnoea | 13.43 | 10.22 | 60 | 136960 | 6042 | 29431465 |
Severe acute respiratory syndrome | 13.42 | 10.22 | 6 | 137014 | 47 | 29437460 |
Presbyopia | 13.38 | 10.22 | 9 | 137011 | 168 | 29437339 |
Candida infection | 13.25 | 10.22 | 32 | 136988 | 15193 | 29422314 |
Elbow operation | 13.24 | 10.22 | 8 | 137012 | 123 | 29437384 |
Bronchospasm | 13.23 | 10.22 | 83 | 136937 | 9526 | 29427981 |
Tubulointerstitial nephritis and uveitis syndrome | 13.16 | 10.22 | 7 | 137013 | 83 | 29437424 |
Joint effusion | 13.14 | 10.22 | 46 | 136974 | 4138 | 29433369 |
Burn oral cavity | 13.14 | 10.22 | 3 | 137017 | 0 | 29437507 |
Pigment nephropathy | 13.14 | 10.22 | 3 | 137017 | 0 | 29437507 |
Vestibular ataxia | 13.14 | 10.22 | 3 | 137017 | 0 | 29437507 |
Atrio-oesophageal fistula | 13.14 | 10.22 | 3 | 137017 | 0 | 29437507 |
Pneumonia aspiration | 13.09 | 10.22 | 108 | 136912 | 36629 | 29400878 |
Nasal septum deviation | 13.05 | 10.22 | 19 | 137001 | 940 | 29436567 |
Spondylitis | 13.04 | 10.22 | 20 | 137000 | 1037 | 29436470 |
Mesenteric panniculitis | 13.02 | 10.22 | 8 | 137012 | 127 | 29437380 |
Aspergillus infection | 12.99 | 10.22 | 18 | 137002 | 10563 | 29426944 |
Cardiomyopathy | 12.93 | 10.22 | 31 | 136989 | 14756 | 29422751 |
Bacteraemia | 12.91 | 10.22 | 36 | 136984 | 16287 | 29421220 |
Allergic respiratory disease | 12.89 | 10.22 | 5 | 137015 | 26 | 29437481 |
Ear canal stenosis | 12.84 | 10.22 | 4 | 137016 | 9 | 29437498 |
Urinary tract infection | 12.82 | 10.22 | 247 | 136773 | 72107 | 29365400 |
Neutrophil Pelger-Huet anomaly present | 12.79 | 10.22 | 10 | 137010 | 238 | 29437269 |
Gastrooesophageal reflux disease | 12.75 | 10.22 | 211 | 136809 | 31285 | 29406222 |
Vascular pseudoaneurysm | 12.72 | 10.22 | 28 | 136992 | 1921 | 29435586 |
Blood pressure systolic increased | 12.70 | 10.22 | 38 | 136982 | 16807 | 29420700 |
Nephrolithiasis | 12.69 | 10.22 | 176 | 136844 | 25158 | 29412349 |
Inflammation | 12.67 | 10.22 | 161 | 136859 | 22567 | 29414940 |
Drug reaction with eosinophilia and systemic symptoms | 12.65 | 10.22 | 191 | 136829 | 27801 | 29409706 |
Febrile convulsion | 12.51 | 10.22 | 14 | 137006 | 531 | 29436976 |
Tremor | 12.43 | 10.22 | 253 | 136767 | 73285 | 29364222 |
Acid-base balance disorder mixed | 12.43 | 10.22 | 6 | 137014 | 57 | 29437450 |
Orbital oedema | 12.39 | 10.22 | 8 | 137012 | 139 | 29437368 |
Product use in unapproved indication | 12.38 | 10.22 | 307 | 136713 | 86568 | 29350939 |
Subdural haematoma | 12.35 | 10.22 | 43 | 136977 | 18150 | 29419357 |
Akathisia | 12.34 | 10.22 | 8 | 137012 | 6734 | 29430773 |
Escherichia pyelonephritis | 12.34 | 10.22 | 6 | 137014 | 58 | 29437449 |
Product dose omission issue | 12.32 | 10.22 | 346 | 136674 | 96037 | 29341470 |
Dermatitis acneiform | 12.31 | 10.22 | 5 | 137015 | 5486 | 29432021 |
Electrocardiogram QT shortened | 12.29 | 10.22 | 8 | 137012 | 141 | 29437366 |
Hypogammaglobulinaemia | 12.26 | 10.22 | 6 | 137014 | 5901 | 29431606 |
Ear injury | 12.17 | 10.22 | 5 | 137015 | 31 | 29437476 |
Thrombosis | 12.16 | 10.22 | 134 | 136886 | 42911 | 29394596 |
Liver disorder | 12.10 | 10.22 | 77 | 136943 | 27672 | 29409835 |
Anhidrosis | 12.09 | 10.22 | 7 | 137013 | 99 | 29437408 |
Bone disorder | 12.08 | 10.22 | 56 | 136964 | 5727 | 29431780 |
Foreign body in throat | 12.08 | 10.22 | 6 | 137014 | 61 | 29437446 |
Ischaemic stroke | 12.08 | 10.22 | 36 | 136984 | 15941 | 29421566 |
Immune reconstitution inflammatory syndrome | 12.06 | 10.22 | 11 | 137009 | 7791 | 29429716 |
Coma | 12.05 | 10.22 | 253 | 136767 | 39197 | 29398310 |
Complement factor C4 decreased | 12.03 | 10.22 | 4 | 137016 | 12 | 29437495 |
Sensation of foreign body | 12.00 | 10.22 | 26 | 136994 | 1764 | 29435743 |
Paranasal sinus mucosal hypertrophy | 12.00 | 10.22 | 6 | 137014 | 62 | 29437445 |
Anaphylactic shock | 11.95 | 10.22 | 104 | 136916 | 13232 | 29424275 |
Oral mucosa erosion | 11.94 | 10.22 | 17 | 137003 | 824 | 29436683 |
Blood ethanol increased | 11.94 | 10.22 | 13 | 137007 | 478 | 29437029 |
Pelvic fluid collection | 11.91 | 10.22 | 7 | 137013 | 102 | 29437405 |
Capillary nail refill test abnormal | 11.91 | 10.22 | 5 | 137015 | 33 | 29437474 |
Focal segmental glomerulosclerosis | 11.84 | 10.22 | 26 | 136994 | 1781 | 29435726 |
Hemiplegia | 11.83 | 10.22 | 8 | 137012 | 6586 | 29430921 |
Ventricular tachycardia | 11.82 | 10.22 | 59 | 136961 | 22515 | 29414992 |
Pneumonia fungal | 11.80 | 10.22 | 6 | 137014 | 5771 | 29431736 |
Bladder discomfort | 11.79 | 10.22 | 7 | 137013 | 104 | 29437403 |
Muscle injury | 11.75 | 10.22 | 20 | 137000 | 1133 | 29436374 |
Hereditary angioedema | 11.73 | 10.22 | 16 | 137004 | 745 | 29436762 |
Colonic abscess | 11.68 | 10.22 | 12 | 137008 | 412 | 29437095 |
Mucosal inflammation | 11.67 | 10.22 | 92 | 136928 | 31503 | 29406004 |
Arrhythmia | 11.64 | 10.22 | 91 | 136929 | 31222 | 29406285 |
Respiratory tract oedema | 11.63 | 10.22 | 11 | 137009 | 341 | 29437166 |
Ureteric obstruction | 11.62 | 10.22 | 20 | 137000 | 1143 | 29436364 |
Blood pressure increased | 11.58 | 10.22 | 257 | 136763 | 73546 | 29363961 |
Alcohol poisoning | 11.52 | 10.22 | 36 | 136984 | 3053 | 29434454 |
Stomatitis | 11.52 | 10.22 | 113 | 136907 | 37000 | 29400507 |
Therapy non-responder | 11.42 | 10.22 | 90 | 136930 | 30821 | 29406686 |
Agitation | 11.42 | 10.22 | 315 | 136705 | 50989 | 29386518 |
Hyperammonaemia | 11.39 | 10.22 | 6 | 137014 | 5657 | 29431850 |
Fusobacterium infection | 11.37 | 10.22 | 6 | 137014 | 70 | 29437437 |
Pneumonia bacterial | 11.37 | 10.22 | 16 | 137004 | 9327 | 29428180 |
Orthostatic hypotension | 11.36 | 10.22 | 60 | 136960 | 22569 | 29414938 |
Hepatic cancer | 11.36 | 10.22 | 8 | 137012 | 6448 | 29431059 |
Rash macular | 11.35 | 10.22 | 85 | 136935 | 10340 | 29427167 |
Medication error | 11.30 | 10.22 | 149 | 136871 | 21062 | 29416445 |
Myelosuppression | 11.20 | 10.22 | 25 | 136995 | 12202 | 29425305 |
Anxiety | 11.17 | 10.22 | 493 | 136527 | 84872 | 29352635 |
Lung neoplasm malignant | 11.11 | 10.22 | 32 | 136988 | 14325 | 29423182 |
Pharyngeal erythema | 11.08 | 10.22 | 13 | 137007 | 519 | 29436988 |
Spinal meningeal cyst | 11.07 | 10.22 | 3 | 137017 | 3 | 29437504 |
Peritonsillitis | 11.07 | 10.22 | 3 | 137017 | 3 | 29437504 |
Oculoauriculovertebral dysplasia | 11.07 | 10.22 | 3 | 137017 | 3 | 29437504 |
Vertebral artery hypoplasia | 11.07 | 10.22 | 3 | 137017 | 3 | 29437504 |
Kernicterus | 11.07 | 10.22 | 3 | 137017 | 3 | 29437504 |
Multiple sclerosis | 11.03 | 10.22 | 53 | 136967 | 5501 | 29432006 |
Colostomy closure | 10.99 | 10.22 | 5 | 137015 | 41 | 29437466 |
Ligament injury | 10.98 | 10.22 | 10 | 137010 | 295 | 29437212 |
Social anxiety disorder | 10.97 | 10.22 | 9 | 137011 | 230 | 29437277 |
Antineutrophil cytoplasmic antibody | 10.96 | 10.22 | 4 | 137016 | 17 | 29437490 |
Transmission of an infectious agent via product | 10.96 | 10.22 | 8 | 137012 | 171 | 29437336 |
Meniscus injury | 10.94 | 10.22 | 26 | 136994 | 1877 | 29435630 |
Heat stroke | 10.93 | 10.22 | 17 | 137003 | 892 | 29436615 |
Cardiac failure acute | 10.93 | 10.22 | 16 | 137004 | 9176 | 29428331 |
Generalised oedema | 10.92 | 10.22 | 22 | 136998 | 11143 | 29426364 |
Mycoplasma infection | 10.90 | 10.22 | 10 | 137010 | 298 | 29437209 |
Accidental overdose | 10.84 | 10.22 | 127 | 136893 | 17466 | 29420041 |
Gastrointestinal erosion | 10.82 | 10.22 | 11 | 137009 | 373 | 29437134 |
Oropharyngeal swelling | 10.76 | 10.22 | 12 | 137008 | 453 | 29437054 |
Dermatitis bullous | 10.76 | 10.22 | 55 | 136965 | 5851 | 29431656 |
Emotional distress | 10.75 | 10.22 | 105 | 136915 | 13790 | 29423717 |
Mediastinitis | 10.68 | 10.22 | 14 | 137006 | 627 | 29436880 |
Congestive cardiomyopathy | 10.67 | 10.22 | 9 | 137011 | 6621 | 29430886 |
Red blood cell sedimentation rate | 10.66 | 10.22 | 13 | 137007 | 541 | 29436966 |
Klebsiella infection | 10.62 | 10.22 | 11 | 137009 | 7338 | 29430169 |
Anxiety disorder due to a general medical condition | 10.61 | 10.22 | 3 | 137017 | 4 | 29437503 |
Hepatic cirrhosis | 10.59 | 10.22 | 33 | 136987 | 14411 | 29423096 |
Pyrexia | 10.58 | 10.22 | 1169 | 135851 | 286453 | 29151054 |
Tension headache | 10.57 | 10.22 | 21 | 136999 | 1340 | 29436167 |
Lumbar radiculopathy | 10.55 | 10.22 | 15 | 137005 | 726 | 29436781 |
Dementia | 10.55 | 10.22 | 24 | 136996 | 11634 | 29425873 |
Kounis syndrome | 10.52 | 10.22 | 25 | 136995 | 1804 | 29435703 |
Allergy to chemicals | 10.50 | 10.22 | 5 | 137015 | 46 | 29437461 |
Iritis | 10.49 | 10.22 | 20 | 137000 | 1238 | 29436269 |
Mental fatigue | 10.48 | 10.22 | 6 | 137014 | 83 | 29437424 |
Cross sensitivity reaction | 10.44 | 10.22 | 20 | 137000 | 1242 | 29436265 |
Axillary pain | 10.44 | 10.22 | 10 | 137010 | 315 | 29437192 |
Metatarsalgia | 10.42 | 10.22 | 6 | 137014 | 84 | 29437423 |
Circumoral oedema | 10.41 | 10.22 | 5 | 137015 | 47 | 29437460 |
Hiatus hernia | 10.36 | 10.22 | 60 | 136960 | 6692 | 29430815 |
Haemorrhoids thrombosed | 10.35 | 10.22 | 8 | 137012 | 187 | 29437320 |
Bladder neck obstruction | 10.35 | 10.22 | 7 | 137013 | 132 | 29437375 |
Application site haematoma | 10.23 | 10.22 | 5 | 137015 | 49 | 29437458 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 1077.69 | 9.79 | 1521 | 359878 | 60300 | 64077033 |
Intentional overdose | 1067.48 | 9.79 | 1854 | 359545 | 88090 | 64049243 |
Drug hypersensitivity | 594.62 | 9.79 | 2773 | 358626 | 235042 | 63902291 |
Injury | 467.80 | 9.79 | 995 | 360404 | 54997 | 64082336 |
Cholecystitis chronic | 461.90 | 9.79 | 397 | 361002 | 8890 | 64128443 |
Off label use | 459.11 | 9.79 | 1908 | 359491 | 630898 | 63506435 |
Urticaria | 457.00 | 9.79 | 1834 | 359565 | 145483 | 63991850 |
Suicide attempt | 439.83 | 9.79 | 1122 | 360277 | 69885 | 64067448 |
Aspirin-exacerbated respiratory disease | 388.16 | 9.79 | 169 | 361230 | 991 | 64136342 |
Haematemesis | 380.87 | 9.79 | 825 | 360574 | 46174 | 64091159 |
Pneumonia | 368.76 | 9.79 | 1748 | 359651 | 557828 | 63579505 |
Febrile neutropenia | 357.54 | 9.79 | 315 | 361084 | 187342 | 63949991 |
Tubulointerstitial nephritis | 357.02 | 9.79 | 630 | 360769 | 30279 | 64107054 |
Death | 349.79 | 9.79 | 1455 | 359944 | 481250 | 63656083 |
Abdominal pain upper | 337.74 | 9.79 | 1899 | 359500 | 173131 | 63964202 |
Overdose | 313.64 | 9.79 | 1740 | 359659 | 157826 | 63979507 |
Muscle injury | 302.94 | 9.79 | 537 | 360862 | 25900 | 64111433 |
Completed suicide | 301.22 | 9.79 | 2221 | 359178 | 222193 | 63915140 |
Lip oedema | 297.83 | 9.79 | 241 | 361158 | 4948 | 64132385 |
Duodenal ulcer perforation | 292.26 | 9.79 | 618 | 360781 | 34007 | 64103326 |
Emotional distress | 284.46 | 9.79 | 626 | 360773 | 35412 | 64101921 |
Interstitial lung disease | 279.56 | 9.79 | 99 | 361300 | 97633 | 64039700 |
Irritable bowel syndrome | 270.30 | 9.79 | 627 | 360772 | 36742 | 64100591 |
Melaena | 258.89 | 9.79 | 773 | 360626 | 52775 | 64084558 |
Gastric ulcer | 256.76 | 9.79 | 541 | 360858 | 29693 | 64107640 |
Uterine perforation | 251.96 | 9.79 | 230 | 361169 | 5590 | 64131743 |
Renal tubular acidosis | 245.93 | 9.79 | 172 | 361227 | 2807 | 64134526 |
Folliculitis | 244.83 | 9.79 | 529 | 360870 | 29548 | 64107785 |
Sleep disorder due to general medical condition, insomnia type | 243.05 | 9.79 | 487 | 360912 | 25783 | 64111550 |
Cardiac failure | 225.67 | 9.79 | 245 | 361154 | 132128 | 64005205 |
Duodenal ulcer | 222.05 | 9.79 | 335 | 361064 | 14100 | 64123233 |
Neutropenia | 221.79 | 9.79 | 650 | 360749 | 238974 | 63898359 |
Toxicity to various agents | 221.31 | 9.79 | 3054 | 358345 | 360459 | 63776874 |
Pruritus | 204.69 | 9.79 | 2660 | 358739 | 309740 | 63827593 |
Cardiac failure congestive | 191.80 | 9.79 | 271 | 361128 | 130309 | 64007024 |
Upper gastrointestinal haemorrhage | 190.11 | 9.79 | 529 | 360870 | 34691 | 64102642 |
Metabolic acidosis | 184.67 | 9.79 | 838 | 360561 | 70120 | 64067213 |
Acute kidney injury | 181.63 | 9.79 | 3528 | 357871 | 445712 | 63691621 |
Platelet count decreased | 180.25 | 9.79 | 422 | 360977 | 167289 | 63970044 |
Blister | 178.78 | 9.79 | 912 | 360487 | 80055 | 64057278 |
Pain | 176.95 | 9.79 | 4201 | 357198 | 549310 | 63588023 |
Meningitis aseptic | 176.41 | 9.79 | 188 | 361211 | 5542 | 64131791 |
Helicobacter infection | 176.23 | 9.79 | 544 | 360855 | 37818 | 64099515 |
Glomerulonephritis minimal lesion | 165.92 | 9.79 | 80 | 361319 | 613 | 64136720 |
Gallbladder disorder | 165.12 | 9.79 | 322 | 361077 | 16708 | 64120625 |
Sepsis | 158.60 | 9.79 | 707 | 360692 | 229634 | 63907699 |
Face oedema | 157.11 | 9.79 | 395 | 361004 | 24366 | 64112967 |
Gastric haemorrhage | 154.64 | 9.79 | 274 | 361125 | 13207 | 64124126 |
Gastric ulcer perforation | 153.82 | 9.79 | 106 | 361293 | 1687 | 64135646 |
Thrombocytopenia | 153.44 | 9.79 | 688 | 360711 | 223113 | 63914220 |
Malignant neoplasm progression | 153.42 | 9.79 | 247 | 361152 | 112624 | 64024709 |
Wound closure | 149.28 | 9.79 | 50 | 361349 | 119 | 64137214 |
Eyelid oedema | 149.22 | 9.79 | 256 | 361143 | 12023 | 64125310 |
Stevens-Johnson syndrome | 147.52 | 9.79 | 475 | 360924 | 33774 | 64103559 |
Gastrointestinal haemorrhage | 146.83 | 9.79 | 1254 | 360145 | 131058 | 64006275 |
Drug resistance | 143.13 | 9.79 | 15 | 361384 | 35087 | 64102246 |
Vomiting | 141.20 | 9.79 | 4063 | 357336 | 547054 | 63590279 |
Osteotomy | 140.09 | 9.79 | 51 | 361348 | 169 | 64137164 |
Lower respiratory tract infection | 137.47 | 9.79 | 955 | 360444 | 93659 | 64043674 |
Peritonsillar abscess | 136.92 | 9.79 | 73 | 361326 | 707 | 64136626 |
Gastritis | 136.29 | 9.79 | 536 | 360863 | 42082 | 64095251 |
Biliary dyskinesia | 135.78 | 9.79 | 110 | 361289 | 2262 | 64135071 |
Sinusitis | 132.62 | 9.79 | 1325 | 360074 | 144603 | 63992730 |
Impaired healing | 131.97 | 9.79 | 679 | 360720 | 59794 | 64077539 |
Muscle spasticity | 126.40 | 9.79 | 285 | 361114 | 16384 | 64120949 |
Cytomegalovirus infection | 124.27 | 9.79 | 28 | 361371 | 37171 | 64100162 |
Duodenal ulcer haemorrhage | 124.25 | 9.79 | 165 | 361234 | 6160 | 64131173 |
Atrial fibrillation | 123.30 | 9.79 | 516 | 360883 | 170573 | 63966760 |
Toxic epidermal necrolysis | 121.74 | 9.79 | 471 | 360928 | 36695 | 64100638 |
Hypersensitivity | 119.46 | 9.79 | 1651 | 359748 | 194801 | 63942532 |
Lip swelling | 119.30 | 9.79 | 422 | 360977 | 31485 | 64105848 |
Fall | 118.91 | 9.79 | 1633 | 359766 | 415193 | 63722140 |
Ear pain | 117.82 | 9.79 | 359 | 361040 | 24777 | 64112556 |
Pancytopenia | 114.93 | 9.79 | 414 | 360985 | 142895 | 63994438 |
Anaphylactic reaction | 110.52 | 9.79 | 711 | 360688 | 67953 | 64069380 |
Palatal oedema | 110.38 | 9.79 | 74 | 361325 | 1123 | 64136210 |
Disease progression | 109.88 | 9.79 | 415 | 360984 | 141265 | 63996068 |
Enthesopathy | 101.79 | 9.79 | 189 | 361210 | 9449 | 64127884 |
Renal papillary necrosis | 99.37 | 9.79 | 46 | 361353 | 318 | 64137015 |
Discomfort | 97.97 | 9.79 | 782 | 360617 | 80096 | 64057237 |
Hypervolaemia | 94.69 | 9.79 | 48 | 361351 | 38237 | 64099096 |
Gastrointestinal disorder | 94.67 | 9.79 | 841 | 360558 | 88868 | 64048465 |
Deep vein thrombosis | 93.10 | 9.79 | 950 | 360449 | 104232 | 64033101 |
Intentional self-injury | 92.62 | 9.79 | 365 | 361034 | 28679 | 64108654 |
Septic shock | 91.73 | 9.79 | 294 | 361105 | 105143 | 64032190 |
Hospitalisation | 90.95 | 9.79 | 177 | 361222 | 75030 | 64062303 |
Self-medication | 90.61 | 9.79 | 114 | 361285 | 4031 | 64133302 |
Bone marrow failure | 89.41 | 9.79 | 82 | 361317 | 47870 | 64089463 |
Renal impairment | 88.93 | 9.79 | 421 | 360978 | 134596 | 64002737 |
Kounis syndrome | 87.43 | 9.79 | 96 | 361303 | 2929 | 64134404 |
Glomerulonephritis membranous | 87.16 | 9.79 | 67 | 361332 | 1273 | 64136060 |
Myocardial infarction | 86.29 | 9.79 | 559 | 360840 | 165262 | 63972071 |
Foreign body in throat | 85.41 | 9.79 | 35 | 361364 | 172 | 64137161 |
Fixed eruption | 85.12 | 9.79 | 81 | 361318 | 2078 | 64135255 |
Ascites | 84.86 | 9.79 | 135 | 361264 | 61866 | 64075467 |
Neutrophil count decreased | 84.68 | 9.79 | 192 | 361207 | 77004 | 64060329 |
Plasma cell myeloma | 84.49 | 9.79 | 80 | 361319 | 45995 | 64091338 |
Gastritis erosive | 84.14 | 9.79 | 174 | 361225 | 9421 | 64127912 |
Respiratory failure | 84.06 | 9.79 | 543 | 360856 | 160640 | 63976693 |
Tongue oedema | 83.71 | 9.79 | 133 | 361266 | 5857 | 64131476 |
White blood cell count decreased | 83.19 | 9.79 | 530 | 360869 | 157307 | 63980026 |
Cholelithiasis | 83.18 | 9.79 | 487 | 360912 | 45019 | 64092314 |
Tenosynovitis | 82.77 | 9.79 | 196 | 361203 | 11637 | 64125696 |
Fluid retention | 82.33 | 9.79 | 129 | 361270 | 59477 | 64077856 |
Suspected suicide | 80.72 | 9.79 | 161 | 361238 | 8493 | 64128840 |
Diarrhoea | 79.91 | 9.79 | 3276 | 358123 | 719428 | 63417905 |
Analgesic drug level increased | 79.84 | 9.79 | 80 | 361319 | 2190 | 64135143 |
Joint swelling | 78.29 | 9.79 | 1666 | 359733 | 213716 | 63923617 |
Clostridium difficile infection | 77.25 | 9.79 | 54 | 361345 | 36109 | 64101224 |
Hepatic function abnormal | 77.21 | 9.79 | 152 | 361247 | 64161 | 64073172 |
Pericarditis | 77.09 | 9.79 | 607 | 360792 | 61909 | 64075424 |
Psoriatic arthropathy | 77.06 | 9.79 | 460 | 360939 | 42821 | 64094512 |
Vanishing bile duct syndrome | 76.88 | 9.79 | 61 | 361338 | 1216 | 64136117 |
Intestinal diaphragm disease | 76.60 | 9.79 | 38 | 361361 | 312 | 64137021 |
Ill-defined disorder | 75.76 | 9.79 | 464 | 360935 | 43588 | 64093745 |
Hypomagnesaemia | 75.71 | 9.79 | 59 | 361340 | 37317 | 64100016 |
Anxiety | 75.11 | 9.79 | 1572 | 359827 | 201077 | 63936256 |
Acute hepatic failure | 74.45 | 9.79 | 317 | 361082 | 25795 | 64111538 |
Hypoglycaemia | 73.17 | 9.79 | 258 | 361141 | 89634 | 64047699 |
Tendonitis | 73.04 | 9.79 | 265 | 361134 | 20017 | 64117316 |
Tongue disorder | 72.78 | 9.79 | 189 | 361210 | 11891 | 64125442 |
Orthostatic hypotension | 72.64 | 9.79 | 93 | 361306 | 46645 | 64090688 |
Wrong technique in product usage process | 72.58 | 9.79 | 160 | 361239 | 64814 | 64072519 |
Abdominal pain | 71.65 | 9.79 | 2273 | 359126 | 310102 | 63827231 |
Ankylosing spondylitis | 70.66 | 9.79 | 148 | 361251 | 8086 | 64129247 |
Intentional product misuse | 70.31 | 9.79 | 666 | 360733 | 71629 | 64065704 |
Night sweats | 69.97 | 9.79 | 392 | 361007 | 35654 | 64101679 |
Hypoaldosteronism | 69.67 | 9.79 | 35 | 361364 | 296 | 64137037 |
Oxygen saturation decreased | 69.51 | 9.79 | 336 | 361063 | 106840 | 64030493 |
Transplant rejection | 69.51 | 9.79 | 8 | 361391 | 17393 | 64119940 |
Pulmonary arterial hypertension | 68.67 | 9.79 | 28 | 361371 | 25339 | 64111994 |
Neuropathy peripheral | 68.60 | 9.79 | 382 | 361017 | 117143 | 64020190 |
Pneumocystis jirovecii pneumonia | 66.34 | 9.79 | 36 | 361363 | 27598 | 64109735 |
Pulmonary hypertension | 65.85 | 9.79 | 87 | 361312 | 43052 | 64094281 |
Anaemia | 65.83 | 9.79 | 1617 | 359782 | 377063 | 63760270 |
Anti-cyclic citrullinated peptide antibody positive | 65.44 | 9.79 | 489 | 360910 | 49073 | 64088260 |
Peptic ulcer | 65.41 | 9.79 | 112 | 361287 | 5251 | 64132082 |
Chronic obstructive pulmonary disease | 64.70 | 9.79 | 194 | 361205 | 70854 | 64066479 |
Swelling | 64.37 | 9.79 | 1258 | 360141 | 158960 | 63978373 |
Medication overuse headache | 63.34 | 9.79 | 43 | 361356 | 667 | 64136666 |
Gallbladder injury | 63.11 | 9.79 | 52 | 361347 | 1096 | 64136237 |
Acute myeloid leukaemia | 62.75 | 9.79 | 38 | 361361 | 27425 | 64109908 |
Haematochezia | 62.35 | 9.79 | 607 | 360792 | 65766 | 64071567 |
Pleural effusion | 62.15 | 9.79 | 434 | 360965 | 126125 | 64011208 |
Graft versus host disease | 61.55 | 9.79 | 4 | 361395 | 13809 | 64123524 |
Gastric ulcer haemorrhage | 61.48 | 9.79 | 139 | 361260 | 8004 | 64129329 |
Drug ineffective | 61.21 | 9.79 | 3974 | 357425 | 836273 | 63301060 |
Red blood cell sedimentation rate abnormal | 59.25 | 9.79 | 10 | 361389 | 16296 | 64121037 |
Myelodysplastic syndrome | 59.15 | 9.79 | 41 | 361358 | 27538 | 64109795 |
Lemierre syndrome | 59.11 | 9.79 | 23 | 361376 | 96 | 64137237 |
Herpes zoster | 58.77 | 9.79 | 236 | 361163 | 78951 | 64058382 |
Acute generalised exanthematous pustulosis | 58.75 | 9.79 | 193 | 361206 | 13865 | 64123468 |
Rash | 58.19 | 9.79 | 3133 | 358266 | 455416 | 63681917 |
Bronchopulmonary aspergillosis | 56.87 | 9.79 | 18 | 361381 | 19067 | 64118266 |
Anhedonia | 56.23 | 9.79 | 187 | 361212 | 13519 | 64123814 |
Pharyngeal abscess | 56.05 | 9.79 | 38 | 361361 | 588 | 64136745 |
Neurotoxicity | 55.84 | 9.79 | 43 | 361356 | 27361 | 64109972 |
Headache | 55.48 | 9.79 | 3556 | 357843 | 525911 | 63611422 |
Pneumonia aspiration | 55.30 | 9.79 | 160 | 361239 | 59111 | 64078222 |
Hypoxia | 55.06 | 9.79 | 280 | 361119 | 87869 | 64049464 |
Swelling face | 55.04 | 9.79 | 540 | 360859 | 58626 | 64078707 |
Peripheral swelling | 54.40 | 9.79 | 1546 | 359853 | 207607 | 63929726 |
Faeces discoloured | 54.11 | 9.79 | 286 | 361113 | 25443 | 64111890 |
Brain empyema | 53.70 | 9.79 | 14 | 361385 | 6 | 64137327 |
Abdominal pain lower | 53.48 | 9.79 | 291 | 361108 | 26178 | 64111155 |
Diabetes mellitus | 53.28 | 9.79 | 192 | 361207 | 66282 | 64071051 |
Deafness transitory | 53.20 | 9.79 | 41 | 361358 | 782 | 64136551 |
Respiratory disorder | 52.71 | 9.79 | 365 | 361034 | 35746 | 64101587 |
Osteoporosis | 52.65 | 9.79 | 97 | 361302 | 41983 | 64095350 |
Gastrointestinal pain | 52.48 | 9.79 | 125 | 361274 | 7449 | 64129884 |
Nasal disorder | 51.74 | 9.79 | 72 | 361327 | 2812 | 64134521 |
Hyponatraemia | 51.33 | 9.79 | 557 | 360842 | 147782 | 63989551 |
Blood pressure increased | 51.24 | 9.79 | 670 | 360729 | 171882 | 63965451 |
Bradycardia | 50.67 | 9.79 | 421 | 360978 | 117798 | 64019535 |
Product prescribing error | 50.60 | 9.79 | 355 | 361044 | 34914 | 64102419 |
Body temperature increased | 50.25 | 9.79 | 365 | 361034 | 36301 | 64101032 |
Product use in unapproved indication | 50.19 | 9.79 | 692 | 360707 | 175926 | 63961407 |
Right ventricular failure | 50.06 | 9.79 | 29 | 361370 | 21442 | 64115891 |
Heavy menstrual bleeding | 49.75 | 9.79 | 165 | 361234 | 11912 | 64125421 |
Multiple organ dysfunction syndrome | 49.67 | 9.79 | 348 | 361051 | 101065 | 64036268 |
Febrile bone marrow aplasia | 48.04 | 9.79 | 4 | 361395 | 11251 | 64126082 |
Laryngeal dyspnoea | 47.25 | 9.79 | 25 | 361374 | 238 | 64137095 |
Red blood cell sedimentation rate | 47.20 | 9.79 | 79 | 361320 | 3635 | 64133698 |
Oesophageal obstruction | 46.92 | 9.79 | 38 | 361361 | 781 | 64136552 |
Medical device discomfort | 46.24 | 9.79 | 50 | 361349 | 1499 | 64135834 |
Mucosal inflammation | 46.13 | 9.79 | 187 | 361212 | 62397 | 64074936 |
Cytokine release syndrome | 45.97 | 9.79 | 30 | 361369 | 20799 | 64116534 |
Cytomegalovirus viraemia | 45.80 | 9.79 | 4 | 361395 | 10824 | 64126509 |
Tumour lysis syndrome | 45.69 | 9.79 | 26 | 361373 | 19414 | 64117919 |
Glossodynia | 45.67 | 9.79 | 559 | 360840 | 64137 | 64073196 |
Bezoar | 45.65 | 9.79 | 59 | 361340 | 2144 | 64135189 |
Hypotension | 45.39 | 9.79 | 1711 | 359688 | 379263 | 63758070 |
Cytopenia | 45.38 | 9.79 | 15 | 361384 | 15456 | 64121877 |
Haematotoxicity | 44.52 | 9.79 | 9 | 361390 | 12887 | 64124446 |
Device related infection | 44.50 | 9.79 | 64 | 361335 | 30562 | 64106771 |
Cerebral infarction | 44.27 | 9.79 | 103 | 361296 | 40941 | 64096392 |
Pelvic pain | 44.00 | 9.79 | 148 | 361251 | 10762 | 64126571 |
Neuroleptic malignant syndrome | 43.98 | 9.79 | 45 | 361354 | 24951 | 64112382 |
Embedded device | 43.94 | 9.79 | 65 | 361334 | 2687 | 64134646 |
Heart rate decreased | 43.51 | 9.79 | 160 | 361239 | 54907 | 64082426 |
Haemoglobin decreased | 43.46 | 9.79 | 800 | 360599 | 194263 | 63943070 |
Dementia | 43.06 | 9.79 | 32 | 361367 | 20734 | 64116599 |
Cardiac disorder | 42.91 | 9.79 | 164 | 361235 | 55652 | 64081681 |
Stomatitis | 42.79 | 9.79 | 857 | 360542 | 108748 | 64028585 |
Alanine aminotransferase abnormal | 42.77 | 9.79 | 109 | 361290 | 6779 | 64130554 |
Leukopenia | 42.72 | 9.79 | 362 | 361037 | 100880 | 64036453 |
Encephalopathy | 42.57 | 9.79 | 177 | 361222 | 58642 | 64078691 |
Post transplant lymphoproliferative disorder | 41.84 | 9.79 | 3 | 361396 | 9541 | 64127792 |
Kidney transplant rejection | 41.66 | 9.79 | 3 | 361396 | 9508 | 64127825 |
Coronavirus infection | 41.31 | 9.79 | 94 | 361305 | 5436 | 64131897 |
Synovitis | 41.12 | 9.79 | 782 | 360617 | 98308 | 64039025 |
Pathogen resistance | 40.79 | 9.79 | 10 | 361389 | 12533 | 64124800 |
Pulmonary oedema | 39.99 | 9.79 | 267 | 361132 | 78407 | 64058926 |
Urinary tract infection | 39.62 | 9.79 | 991 | 360408 | 230605 | 63906728 |
Posterior reversible encephalopathy syndrome | 39.59 | 9.79 | 42 | 361357 | 22904 | 64114429 |
Dermo-hypodermitis | 39.52 | 9.79 | 29 | 361370 | 512 | 64136821 |
Blood glucose increased | 39.46 | 9.79 | 355 | 361044 | 97718 | 64039615 |
Drug-induced liver injury | 39.16 | 9.79 | 424 | 360975 | 47219 | 64090114 |
Nasopharyngitis | 38.86 | 9.79 | 1403 | 359996 | 194670 | 63942663 |
Periorbital oedema | 38.66 | 9.79 | 110 | 361289 | 7304 | 64130029 |
Poisoning | 38.60 | 9.79 | 232 | 361167 | 21647 | 64115686 |
Bone erosion | 38.18 | 9.79 | 9 | 361390 | 11586 | 64125747 |
Ulcer | 38.17 | 9.79 | 240 | 361159 | 22750 | 64114583 |
Cerebral haemorrhage | 38.07 | 9.79 | 152 | 361247 | 50938 | 64086395 |
Arthropathy | 38.05 | 9.79 | 917 | 360482 | 120050 | 64017283 |
Red blood cell count decreased | 37.96 | 9.79 | 141 | 361258 | 48245 | 64089088 |
Productive cough | 37.43 | 9.79 | 248 | 361151 | 72955 | 64064378 |
Hypocalcaemia | 37.30 | 9.79 | 115 | 361284 | 41638 | 64095695 |
Dyspnoea exertional | 37.09 | 9.79 | 251 | 361148 | 73479 | 64063854 |
Aspergillus infection | 36.95 | 9.79 | 23 | 361376 | 16356 | 64120977 |
Obstruction gastric | 36.87 | 9.79 | 43 | 361356 | 1403 | 64135930 |
Pulmonary embolism | 36.70 | 9.79 | 1077 | 360322 | 145279 | 63992054 |
Renal cortical necrosis | 36.60 | 9.79 | 22 | 361377 | 273 | 64137060 |
Blood pressure decreased | 36.46 | 9.79 | 308 | 361091 | 85891 | 64051442 |
Genital haemorrhage | 35.98 | 9.79 | 89 | 361310 | 5433 | 64131900 |
Jejunal ulcer | 35.90 | 9.79 | 19 | 361380 | 181 | 64137152 |
Bronchitis | 35.76 | 9.79 | 413 | 360986 | 108330 | 64029003 |
Renal tubular necrosis | 35.59 | 9.79 | 229 | 361170 | 21881 | 64115452 |
Cardiac failure acute | 35.45 | 9.79 | 24 | 361375 | 16320 | 64121013 |
Conjunctivitis | 35.38 | 9.79 | 215 | 361184 | 20139 | 64117194 |
Hypertensive emergency | 35.26 | 9.79 | 53 | 361346 | 2223 | 64135110 |
COVID-19 | 35.19 | 9.79 | 217 | 361182 | 64923 | 64072410 |
Multiple sclerosis relapse | 35.17 | 9.79 | 369 | 361030 | 40766 | 64096567 |
Beta haemolytic streptococcal infection | 35.06 | 9.79 | 48 | 361351 | 1846 | 64135487 |
Pulmonary infarction | 35.05 | 9.79 | 64 | 361335 | 3158 | 64134175 |
Arthralgia | 34.61 | 9.79 | 2902 | 358497 | 439358 | 63697975 |
Coma scale abnormal | 34.54 | 9.79 | 109 | 361290 | 7665 | 64129668 |
Cataract | 34.22 | 9.79 | 159 | 361240 | 51103 | 64086230 |
Diffuse large B-cell lymphoma | 34.20 | 9.79 | 8 | 361391 | 10353 | 64126980 |
Duodenitis | 34.17 | 9.79 | 99 | 361300 | 6642 | 64130691 |
Sedation complication | 34.17 | 9.79 | 8 | 361391 | 10346 | 64126987 |
Disease recurrence | 34.04 | 9.79 | 79 | 361320 | 31431 | 64105902 |
Nasal obstruction | 33.97 | 9.79 | 40 | 361359 | 1319 | 64136014 |
Discoloured vomit | 33.93 | 9.79 | 37 | 361362 | 1120 | 64136213 |
Product dose omission issue | 33.93 | 9.79 | 831 | 360568 | 193916 | 63943417 |
Tropical infectious disease | 33.85 | 9.79 | 12 | 361387 | 36 | 64137297 |
Hyperglycaemia | 33.51 | 9.79 | 202 | 361197 | 60766 | 64076567 |
Myelosuppression | 33.45 | 9.79 | 51 | 361348 | 23779 | 64113554 |
Blood pressure fluctuation | 33.40 | 9.79 | 163 | 361236 | 51708 | 64085625 |
SJS-TEN overlap | 33.38 | 9.79 | 25 | 361374 | 456 | 64136877 |
Erythema multiforme | 33.34 | 9.79 | 175 | 361224 | 15526 | 64121807 |
Erosive duodenitis | 33.31 | 9.79 | 44 | 361355 | 1634 | 64135699 |
Mucocutaneous disorder | 33.25 | 9.79 | 16 | 361383 | 122 | 64137211 |
Biliary colic | 33.24 | 9.79 | 65 | 361334 | 3379 | 64133954 |
Progressive multifocal leukoencephalopathy | 33.02 | 9.79 | 32 | 361367 | 18200 | 64119133 |
Photophobia | 32.85 | 9.79 | 187 | 361212 | 17106 | 64120227 |
Bacteraemia | 32.82 | 9.79 | 63 | 361336 | 26848 | 64110485 |
Pemphigus | 32.81 | 9.79 | 500 | 360899 | 60201 | 64077132 |
Jejunal ulcer perforation | 32.49 | 9.79 | 15 | 361384 | 103 | 64137230 |
Serotonin syndrome | 32.45 | 9.79 | 112 | 361287 | 39170 | 64098163 |
Gastric perforation | 32.21 | 9.79 | 65 | 361334 | 3458 | 64133875 |
Obstructive airways disorder | 32.18 | 9.79 | 50 | 361349 | 23135 | 64114198 |
Transfusion | 32.11 | 9.79 | 32 | 361367 | 17962 | 64119371 |
Torsade de pointes | 32 | 9.79 | 30 | 361369 | 17333 | 64120000 |
Gallbladder cholesterolosis | 32.00 | 9.79 | 26 | 361373 | 537 | 64136796 |
Liver disorder | 31.89 | 9.79 | 172 | 361227 | 53179 | 64084154 |
Full blood count abnormal | 31.83 | 9.79 | 75 | 361324 | 29682 | 64107651 |
Intestinal obstruction | 31.67 | 9.79 | 101 | 361298 | 36185 | 64101148 |
Rheumatoid arthritis | 31.67 | 9.79 | 1172 | 360227 | 163122 | 63974211 |
Hand deformity | 31.26 | 9.79 | 510 | 360889 | 62261 | 64075072 |
Conjunctival hyperaemia | 31.06 | 9.79 | 68 | 361331 | 3831 | 64133502 |
Metastases to liver | 31.02 | 9.79 | 54 | 361345 | 23887 | 64113446 |
Distichiasis | 30.99 | 9.79 | 8 | 361391 | 3 | 64137330 |
Cystitis haemorrhagic | 30.94 | 9.79 | 4 | 361395 | 7952 | 64129381 |
Medical device pain | 30.77 | 9.79 | 38 | 361361 | 1318 | 64136015 |
Pain in jaw | 30.52 | 9.79 | 121 | 361278 | 40634 | 64096699 |
Femur fracture | 30.50 | 9.79 | 94 | 361305 | 34041 | 64103292 |
Musculoskeletal stiffness | 30.43 | 9.79 | 905 | 360494 | 122301 | 64015032 |
Laryngeal discomfort | 30.39 | 9.79 | 24 | 361375 | 475 | 64136858 |
Hypothermia | 30.35 | 9.79 | 203 | 361196 | 19653 | 64117680 |
Malaise | 30.25 | 9.79 | 1865 | 359534 | 394382 | 63742951 |
Laryngeal oedema | 30.03 | 9.79 | 98 | 361301 | 7015 | 64130318 |
Premature delivery | 29.92 | 9.79 | 36 | 361363 | 18553 | 64118780 |
Hepatitis B | 29.86 | 9.79 | 4 | 361395 | 7741 | 64129592 |
Cholecystectomy | 29.82 | 9.79 | 106 | 361293 | 7926 | 64129407 |
Back pain | 29.62 | 9.79 | 1699 | 359700 | 248472 | 63888861 |
Treatment failure | 29.59 | 9.79 | 468 | 360931 | 116348 | 64020985 |
Cross sensitivity reaction | 29.45 | 9.79 | 61 | 361338 | 3306 | 64134027 |
Constipation | 29.30 | 9.79 | 1021 | 360378 | 228316 | 63909017 |
Throat tightness | 29.16 | 9.79 | 226 | 361173 | 22934 | 64114399 |
Hepatitis acute | 28.96 | 9.79 | 150 | 361249 | 13239 | 64124094 |
Blood parathyroid hormone decreased | 28.89 | 9.79 | 99 | 361300 | 7267 | 64130066 |
Epilepsy | 28.80 | 9.79 | 94 | 361305 | 33437 | 64103896 |
Hepatocellular carcinoma | 28.73 | 9.79 | 6 | 361393 | 8397 | 64128936 |
Parkinsonism | 28.72 | 9.79 | 23 | 361376 | 14350 | 64122983 |
International normalised ratio increased | 28.69 | 9.79 | 294 | 361105 | 78873 | 64058460 |
Aplasia pure red cell | 28.59 | 9.79 | 3 | 361396 | 7011 | 64130322 |
Migraine | 28.57 | 9.79 | 502 | 360897 | 62175 | 64075158 |
Corneal leukoma | 28.53 | 9.79 | 8 | 361391 | 7 | 64137326 |
Therapeutic product effect decreased | 28.41 | 9.79 | 847 | 360552 | 114504 | 64022829 |
Serum sickness-like reaction | 28.34 | 9.79 | 24 | 361375 | 526 | 64136807 |
Toxic shock syndrome streptococcal | 28.31 | 9.79 | 13 | 361386 | 88 | 64137245 |
Acute lung injury | 28.15 | 9.79 | 53 | 361346 | 2678 | 64134655 |
Milk-alkali syndrome | 27.99 | 9.79 | 34 | 361365 | 1159 | 64136174 |
Helicobacter test positive | 27.98 | 9.79 | 32 | 361367 | 1022 | 64136311 |
Cerebrovascular accident | 27.67 | 9.79 | 574 | 360825 | 137009 | 64000324 |
Depression | 27.65 | 9.79 | 1274 | 360125 | 182017 | 63955316 |
Eosinophilic oesophagitis | 27.58 | 9.79 | 22 | 361377 | 442 | 64136891 |
Medication error | 27.56 | 9.79 | 413 | 360986 | 49553 | 64087780 |
Rheumatoid nodule | 27.55 | 9.79 | 142 | 361257 | 12509 | 64124824 |
Flank pain | 27.50 | 9.79 | 170 | 361229 | 16019 | 64121314 |
Allergic respiratory disease | 27.36 | 9.79 | 11 | 361388 | 51 | 64137282 |
Open globe injury | 27.33 | 9.79 | 12 | 361387 | 72 | 64137261 |
Musculoskeletal disorder | 27.33 | 9.79 | 183 | 361216 | 17723 | 64119610 |
Eye swelling | 27.27 | 9.79 | 216 | 361183 | 22065 | 64115268 |
Pelvic venous thrombosis | 27.06 | 9.79 | 41 | 361358 | 1732 | 64135601 |
Catatonia | 26.98 | 9.79 | 5 | 361394 | 7615 | 64129718 |
Second primary malignancy | 26.91 | 9.79 | 18 | 361381 | 12319 | 64125014 |
Blood magnesium decreased | 26.86 | 9.79 | 23 | 361376 | 13882 | 64123451 |
Abdominal discomfort | 26.59 | 9.79 | 1263 | 360136 | 181059 | 63956274 |
Bronchiectasis | 26.57 | 9.79 | 24 | 361375 | 14116 | 64123217 |
Clostridium difficile colitis | 26.49 | 9.79 | 72 | 361327 | 27151 | 64110182 |
Oedema peripheral | 26.47 | 9.79 | 938 | 360461 | 209379 | 63927954 |
Neutropenic sepsis | 26.24 | 9.79 | 57 | 361342 | 23215 | 64114118 |
Foreign body in gastrointestinal tract | 26.22 | 9.79 | 11 | 361388 | 58 | 64137275 |
Peritonitis bacterial | 26.12 | 9.79 | 9 | 361390 | 9034 | 64128299 |
Coma | 26.00 | 9.79 | 659 | 360740 | 86956 | 64050377 |
Gastritis haemorrhagic | 25.97 | 9.79 | 46 | 361353 | 2216 | 64135117 |
Hunger | 25.81 | 9.79 | 67 | 361332 | 4214 | 64133119 |
Blood creatine phosphokinase increased | 25.78 | 9.79 | 207 | 361192 | 58351 | 64078982 |
Blood pressure systolic increased | 25.55 | 9.79 | 167 | 361232 | 49286 | 64088047 |
Scar | 25.53 | 9.79 | 145 | 361254 | 13253 | 64124080 |
Congestive cardiomyopathy | 25.53 | 9.79 | 13 | 361386 | 10331 | 64127002 |
Ventricular tachycardia | 25.49 | 9.79 | 102 | 361297 | 34163 | 64103170 |
General physical health deterioration | 25.49 | 9.79 | 1395 | 360004 | 203030 | 63934303 |
Pericardial effusion | 25.47 | 9.79 | 123 | 361276 | 39131 | 64098202 |
Lung neoplasm malignant | 25.47 | 9.79 | 51 | 361348 | 21397 | 64115936 |
Panniculitis | 25.47 | 9.79 | 108 | 361291 | 8771 | 64128562 |
Cholesterosis | 25.40 | 9.79 | 19 | 361380 | 346 | 64136987 |
Pneumonia fungal | 25.36 | 9.79 | 9 | 361390 | 8868 | 64128465 |
Liver injury | 25.35 | 9.79 | 268 | 361131 | 29664 | 64107669 |
Hypogammaglobulinaemia | 25.33 | 9.79 | 13 | 361386 | 10286 | 64127047 |
Atrioventricular block complete | 25.31 | 9.79 | 26 | 361373 | 14392 | 64122941 |
Electrocardiogram QT prolonged | 25.24 | 9.79 | 304 | 361095 | 79144 | 64058189 |
Genital odour | 25.14 | 9.79 | 6 | 361393 | 0 | 64137333 |
Cardiogenic shock | 25.10 | 9.79 | 95 | 361304 | 32332 | 64105001 |
Granuloma skin | 25.03 | 9.79 | 83 | 361316 | 5991 | 64131342 |
Pregnancy with contraceptive device | 24.88 | 9.79 | 55 | 361344 | 3119 | 64134214 |
Systemic lupus erythematosus rash | 24.71 | 9.79 | 35 | 361364 | 1390 | 64135943 |
Extrapyramidal disorder | 24.52 | 9.79 | 45 | 361354 | 19507 | 64117826 |
Hepatic cirrhosis | 24.52 | 9.79 | 71 | 361328 | 26227 | 64111106 |
Cough | 24.29 | 9.79 | 1415 | 359984 | 300733 | 63836600 |
Nausea | 24.24 | 9.79 | 4870 | 356529 | 780930 | 63356403 |
Immunodeficiency | 24.12 | 9.79 | 33 | 361366 | 16091 | 64121242 |
Pneumonitis | 24.08 | 9.79 | 174 | 361225 | 50191 | 64087142 |
Psychological trauma | 23.98 | 9.79 | 32 | 361367 | 1200 | 64136133 |
Metastases to bone | 23.92 | 9.79 | 49 | 361350 | 20386 | 64116947 |
Insomnia | 23.87 | 9.79 | 1346 | 360053 | 196490 | 63940843 |
Subdural haematoma | 23.85 | 9.79 | 79 | 361320 | 27975 | 64109358 |
Delirium | 23.84 | 9.79 | 260 | 361139 | 68934 | 64068399 |
Erosive oesophagitis | 23.73 | 9.79 | 48 | 361351 | 2558 | 64134775 |
Aplasia | 23.70 | 9.79 | 5 | 361394 | 6948 | 64130385 |
Hyperkalaemia | 23.69 | 9.79 | 411 | 360988 | 100718 | 64036615 |
Disseminated intravascular coagulation | 23.62 | 9.79 | 97 | 361302 | 32251 | 64105082 |
Dehydration | 23.49 | 9.79 | 984 | 360415 | 215779 | 63921554 |
Neoplasm progression | 23.42 | 9.79 | 134 | 361265 | 40830 | 64096503 |
Myoclonus | 23.28 | 9.79 | 68 | 361331 | 25050 | 64112283 |
Tonsillar erythema | 23.18 | 9.79 | 7 | 361392 | 10 | 64137323 |
Intentional product use issue | 23.17 | 9.79 | 385 | 361014 | 94979 | 64042354 |
Dyskinesia | 22.98 | 9.79 | 128 | 361271 | 39260 | 64098073 |
Cerebral venous sinus thrombosis | 22.97 | 9.79 | 39 | 361360 | 1816 | 64135517 |
Unevaluable event | 22.91 | 9.79 | 177 | 361222 | 50312 | 64087021 |
Dyspareunia | 22.85 | 9.79 | 38 | 361361 | 1739 | 64135594 |
Mast cell activation syndrome | 22.85 | 9.79 | 18 | 361381 | 355 | 64136978 |
Multiple sclerosis | 22.84 | 9.79 | 183 | 361216 | 18758 | 64118575 |
Allergy test negative | 22.78 | 9.79 | 7 | 361392 | 11 | 64137322 |
Paraesthesia | 22.71 | 9.79 | 946 | 360453 | 133576 | 64003757 |
Sleep disorder | 22.67 | 9.79 | 465 | 360934 | 59244 | 64078089 |
Epistaxis | 22.61 | 9.79 | 400 | 360999 | 97731 | 64039602 |
Acute pulmonary oedema | 22.60 | 9.79 | 23 | 361376 | 12786 | 64124547 |
Diabetes mellitus inadequate control | 22.59 | 9.79 | 54 | 361345 | 21267 | 64116066 |
Hip fracture | 22.56 | 9.79 | 77 | 361322 | 27022 | 64110311 |
Swollen tongue | 22.53 | 9.79 | 297 | 361102 | 34657 | 64102676 |
Full blood count decreased | 22.52 | 9.79 | 59 | 361340 | 22523 | 64114810 |
Hemiplegia | 22.45 | 9.79 | 23 | 361376 | 12745 | 64124588 |
Meningitis pneumococcal | 22.43 | 9.79 | 18 | 361381 | 365 | 64136968 |
Wound | 22.33 | 9.79 | 574 | 360825 | 75903 | 64061430 |
Therapeutic response decreased | 22.28 | 9.79 | 186 | 361213 | 52002 | 64085331 |
Infertility female | 22.27 | 9.79 | 19 | 361380 | 421 | 64136912 |
Tendon disorder | 22.18 | 9.79 | 82 | 361317 | 6250 | 64131083 |
Dental operation | 22.12 | 9.79 | 27 | 361372 | 925 | 64136408 |
Thrombotic microangiopathy | 22.10 | 9.79 | 37 | 361362 | 16618 | 64120715 |
Genital tract inflammation | 22.09 | 9.79 | 8 | 361391 | 26 | 64137307 |
Creatinine renal clearance decreased | 22.09 | 9.79 | 29 | 361370 | 14392 | 64122941 |
Coronary arterial stent insertion | 21.80 | 9.79 | 3 | 361396 | 5689 | 64131644 |
Decreased appetite | 21.78 | 9.79 | 1322 | 360077 | 279967 | 63857366 |
Pseudomonas infection | 21.69 | 9.79 | 42 | 361357 | 17841 | 64119492 |
Dysmenorrhoea | 21.56 | 9.79 | 45 | 361354 | 2452 | 64134881 |
Pulmonary mass | 21.55 | 9.79 | 66 | 361333 | 23950 | 64113383 |
Gallbladder hypofunction | 21.46 | 9.79 | 19 | 361380 | 443 | 64136890 |
Contraindicated product administered | 21.44 | 9.79 | 772 | 360627 | 107057 | 64030276 |
Cardiac failure chronic | 21.38 | 9.79 | 12 | 361387 | 9029 | 64128304 |
Frequent bowel movements | 21.33 | 9.79 | 44 | 361355 | 18261 | 64119072 |
Epiglottic oedema | 21.28 | 9.79 | 15 | 361384 | 248 | 64137085 |
Cushingoid | 21.22 | 9.79 | 8 | 361391 | 7595 | 64129738 |
Head discomfort | 21.20 | 9.79 | 126 | 361273 | 11708 | 64125625 |
Drug interaction | 21.11 | 9.79 | 1744 | 359655 | 360339 | 63776994 |
Systemic lupus erythematosus | 21.07 | 9.79 | 577 | 360822 | 77035 | 64060298 |
Contusion | 20.99 | 9.79 | 809 | 360590 | 113156 | 64024177 |
Oesophagitis haemorrhagic | 20.95 | 9.79 | 21 | 361378 | 575 | 64136758 |
Viral parotitis | 20.95 | 9.79 | 5 | 361394 | 0 | 64137333 |
Pulmonary fibrosis | 20.95 | 9.79 | 91 | 361308 | 29787 | 64107546 |
Psychotic disorder | 20.93 | 9.79 | 111 | 361288 | 34467 | 64102866 |
Internal injury | 20.88 | 9.79 | 17 | 361382 | 352 | 64136981 |
Diabetic ketoacidosis | 20.86 | 9.79 | 91 | 361308 | 29754 | 64107579 |
Staphylococcal sepsis | 20.74 | 9.79 | 25 | 361374 | 12874 | 64124459 |
Embolism arterial | 20.65 | 9.79 | 30 | 361369 | 1220 | 64136113 |
Thyroid disorder | 20.62 | 9.79 | 21 | 361378 | 11671 | 64125662 |
Dystonia | 20.62 | 9.79 | 47 | 361352 | 18818 | 64118515 |
Pneumonia viral | 20.58 | 9.79 | 9 | 361390 | 7813 | 64129520 |
Staphylococcal infection | 20.57 | 9.79 | 183 | 361216 | 50495 | 64086838 |
Peripheral sensory neuropathy | 20.57 | 9.79 | 20 | 361379 | 11358 | 64125975 |
Respiratory tract infection | 20.52 | 9.79 | 124 | 361275 | 37283 | 64100050 |
Genital pain | 20.46 | 9.79 | 18 | 361381 | 416 | 64136917 |
Peptic ulcer perforation | 20.45 | 9.79 | 17 | 361382 | 363 | 64136970 |
Underdose | 20.43 | 9.79 | 75 | 361324 | 25754 | 64111579 |
Perforated ulcer | 20.40 | 9.79 | 21 | 361378 | 594 | 64136739 |
Muscle rigidity | 20.36 | 9.79 | 42 | 361357 | 17431 | 64119902 |
Urosepsis | 20.35 | 9.79 | 60 | 361339 | 22034 | 64115299 |
Vulval ulceration | 20.31 | 9.79 | 12 | 361387 | 144 | 64137189 |
Intervertebral disc disorder | 20.27 | 9.79 | 63 | 361336 | 4394 | 64132939 |
Uterine leiomyoma | 20.05 | 9.79 | 71 | 361328 | 5298 | 64132035 |
Injection site pain | 20.04 | 9.79 | 473 | 360926 | 110935 | 64026398 |
Poor venous access | 20.03 | 9.79 | 24 | 361375 | 12393 | 64124940 |
Acute respiratory failure | 19.97 | 9.79 | 181 | 361218 | 49753 | 64087580 |
Systemic candida | 19.97 | 9.79 | 3 | 361396 | 5326 | 64132007 |
Procedural pain | 19.90 | 9.79 | 152 | 361247 | 15356 | 64121977 |
Escherichia infection | 19.84 | 9.79 | 34 | 361365 | 15134 | 64122199 |
Jaundice | 19.82 | 9.79 | 382 | 361017 | 48130 | 64089203 |
Haemorrhage intracranial | 19.79 | 9.79 | 68 | 361331 | 23816 | 64113517 |
Candida infection | 19.50 | 9.79 | 100 | 361299 | 31319 | 64106014 |
Hyperventilation | 19.46 | 9.79 | 83 | 361316 | 6757 | 64130576 |
Mallory-Weiss syndrome | 19.40 | 9.79 | 44 | 361355 | 2539 | 64134794 |
Foot operation | 19.39 | 9.79 | 60 | 361339 | 4175 | 64133158 |
Metastases to lung | 19.26 | 9.79 | 35 | 361364 | 15229 | 64122104 |
Bunion operation | 19.26 | 9.79 | 23 | 361376 | 770 | 64136563 |
Toxic encephalopathy | 19.24 | 9.79 | 16 | 361383 | 9799 | 64127534 |
Shoulder arthroplasty | 19.08 | 9.79 | 45 | 361354 | 2664 | 64134669 |
Sacroiliitis | 19.05 | 9.79 | 48 | 361351 | 2964 | 64134369 |
Bladder cancer | 19.03 | 9.79 | 20 | 361379 | 10954 | 64126379 |
Hepatitis cholestatic | 19.02 | 9.79 | 125 | 361274 | 12030 | 64125303 |
Protein-losing gastroenteropathy | 18.91 | 9.79 | 19 | 361380 | 522 | 64136811 |
Tinnitus | 18.77 | 9.79 | 282 | 361117 | 33851 | 64103482 |
Left ventricular failure | 18.74 | 9.79 | 12 | 361387 | 8405 | 64128928 |
Gastritis bacterial | 18.70 | 9.79 | 15 | 361384 | 304 | 64137029 |
Cardiotoxicity | 18.64 | 9.79 | 18 | 361381 | 10256 | 64127077 |
Prepyloric stenosis | 18.62 | 9.79 | 5 | 361394 | 3 | 64137330 |
Anhidrosis | 18.54 | 9.79 | 13 | 361386 | 213 | 64137120 |
Head injury | 18.47 | 9.79 | 108 | 361291 | 32734 | 64104599 |
Chromaturia | 18.47 | 9.79 | 201 | 361198 | 22410 | 64114923 |
Duodenal stenosis | 18.45 | 9.79 | 21 | 361378 | 667 | 64136666 |
Poisoning deliberate | 18.45 | 9.79 | 134 | 361265 | 13324 | 64124009 |
Duodenal ulcer repair | 18.45 | 9.79 | 9 | 361390 | 71 | 64137262 |
Trichiasis | 18.45 | 9.79 | 9 | 361390 | 71 | 64137262 |
Gastrointestinal ulcer | 18.41 | 9.79 | 48 | 361351 | 3027 | 64134306 |
Pneumonia streptococcal | 18.41 | 9.79 | 41 | 361358 | 2337 | 64134996 |
Fear of disease | 18.38 | 9.79 | 24 | 361375 | 881 | 64136452 |
Acidosis | 18.33 | 9.79 | 166 | 361233 | 17629 | 64119704 |
Atrial flutter | 18.31 | 9.79 | 52 | 361347 | 19328 | 64118005 |
Rales | 18.27 | 9.79 | 36 | 361363 | 15193 | 64122140 |
Stress cardiomyopathy | 18.26 | 9.79 | 15 | 361384 | 9242 | 64128091 |
Ischaemic stroke | 18.25 | 9.79 | 92 | 361307 | 28943 | 64108390 |
Weight decreased | 18.24 | 9.79 | 1366 | 360033 | 284373 | 63852960 |
Oropharyngeal blistering | 18.21 | 9.79 | 21 | 361378 | 677 | 64136656 |
Duodenal obstruction | 18.08 | 9.79 | 16 | 361383 | 373 | 64136960 |
Pulmonary tuberculosis | 18.03 | 9.79 | 9 | 361390 | 7235 | 64130098 |
Prescribed underdose | 18.02 | 9.79 | 47 | 361352 | 17968 | 64119365 |
Dactylitis | 18.01 | 9.79 | 36 | 361363 | 1902 | 64135431 |
Dyspepsia | 17.99 | 9.79 | 583 | 360816 | 79729 | 64057604 |
Infection | 17.89 | 9.79 | 1234 | 360165 | 183646 | 63953687 |
Fear of injection | 17.81 | 9.79 | 73 | 361326 | 5839 | 64131494 |
Food refusal | 17.80 | 9.79 | 17 | 361382 | 438 | 64136895 |
Chemical burn | 17.74 | 9.79 | 17 | 361382 | 440 | 64136893 |
Sinus node dysfunction | 17.74 | 9.79 | 8 | 361391 | 6820 | 64130513 |
Blood glucose decreased | 17.73 | 9.79 | 68 | 361331 | 23055 | 64114278 |
Anoxia | 17.67 | 9.79 | 15 | 361384 | 330 | 64137003 |
Glaucoma | 17.65 | 9.79 | 41 | 361358 | 16307 | 64121026 |
Cervicobrachial syndrome | 17.63 | 9.79 | 25 | 361374 | 994 | 64136339 |
Malnutrition | 17.57 | 9.79 | 52 | 361347 | 19073 | 64118260 |
Functional gastrointestinal disorder | 17.52 | 9.79 | 57 | 361342 | 4074 | 64133259 |
Hepatic cancer | 17.45 | 9.79 | 10 | 361389 | 7438 | 64129895 |
Muscle swelling | 17.45 | 9.79 | 21 | 361378 | 709 | 64136624 |
Skin cancer | 17.42 | 9.79 | 25 | 361374 | 11949 | 64125384 |
Macrophages increased | 17.31 | 9.79 | 12 | 361387 | 193 | 64137140 |
Nocardiosis | 17.15 | 9.79 | 3 | 361396 | 4764 | 64132569 |
Rash maculo-papular | 17.12 | 9.79 | 364 | 361035 | 46662 | 64090671 |
Needle issue | 17.11 | 9.79 | 16 | 361383 | 9256 | 64128077 |
Necrotising fasciitis | 17.03 | 9.79 | 67 | 361332 | 5259 | 64132074 |
Myopathy | 17.02 | 9.79 | 47 | 361352 | 17633 | 64119700 |
Pasteurella infection | 16.98 | 9.79 | 7 | 361392 | 35 | 64137298 |
Kidney enlargement | 16.94 | 9.79 | 25 | 361374 | 1031 | 64136302 |
Device malfunction | 16.89 | 9.79 | 47 | 361352 | 17586 | 64119747 |
Leukoencephalopathy | 16.83 | 9.79 | 9 | 361390 | 6958 | 64130375 |
Device leakage | 16.80 | 9.79 | 13 | 361386 | 8253 | 64129080 |
Muscle tone disorder | 16.78 | 9.79 | 10 | 361389 | 122 | 64137211 |
Shoulder injury related to vaccine administration | 16.76 | 9.79 | 4 | 361395 | 0 | 64137333 |
Salivary gland cyst | 16.76 | 9.79 | 4 | 361395 | 0 | 64137333 |
Lymphoproliferative disorder | 16.73 | 9.79 | 4 | 361395 | 5099 | 64132234 |
Tobacco abuse | 16.72 | 9.79 | 22 | 361377 | 814 | 64136519 |
Infection masked | 16.71 | 9.79 | 10 | 361389 | 123 | 64137210 |
Xyphoid retraction | 16.69 | 9.79 | 11 | 361388 | 162 | 64137171 |
Glycosylated haemoglobin increased | 16.64 | 9.79 | 41 | 361358 | 15978 | 64121355 |
Gastric mucosa erythema | 16.59 | 9.79 | 15 | 361384 | 360 | 64136973 |
B-cell lymphoma | 16.52 | 9.79 | 5 | 361394 | 5452 | 64131881 |
Allergy test positive | 16.51 | 9.79 | 16 | 361383 | 420 | 64136913 |
Suicidal ideation | 16.48 | 9.79 | 489 | 360910 | 66053 | 64071280 |
Eosinophil count increased | 16.38 | 9.79 | 34 | 361365 | 14078 | 64123255 |
Ejection fraction decreased | 16.36 | 9.79 | 94 | 361305 | 28613 | 64108720 |
Hepatic necrosis | 16.34 | 9.79 | 92 | 361307 | 8381 | 64128952 |
Nodule | 16.34 | 9.79 | 49 | 361350 | 17898 | 64119435 |
Epstein-Barr virus infection | 16.33 | 9.79 | 28 | 361371 | 12460 | 64124873 |
Therapeutic product effect incomplete | 16.30 | 9.79 | 448 | 360951 | 103034 | 64034299 |
Electrocardiogram QRS complex prolonged | 16.29 | 9.79 | 98 | 361301 | 9146 | 64128187 |
Organising pneumonia | 16.27 | 9.79 | 16 | 361383 | 9039 | 64128294 |
Sedation | 16.27 | 9.79 | 151 | 361248 | 41311 | 64096022 |
Ceruloplasmin decreased | 16.23 | 9.79 | 6 | 361393 | 21 | 64137312 |
Rash pruritic | 16.22 | 9.79 | 429 | 360970 | 56975 | 64080358 |
Oral mucosa erosion | 16.21 | 9.79 | 32 | 361367 | 1675 | 64135658 |
Psoriasis | 16.18 | 9.79 | 521 | 360878 | 71182 | 64066151 |
Device occlusion | 16.16 | 9.79 | 19 | 361380 | 9894 | 64127439 |
Oral pruritus | 16.14 | 9.79 | 33 | 361366 | 1772 | 64135561 |
Cardiomyopathy | 16.13 | 9.79 | 80 | 361319 | 25276 | 64112057 |
Abdominal tenderness | 16.13 | 9.79 | 99 | 361300 | 9306 | 64128027 |
Endophthalmitis | 16.09 | 9.79 | 5 | 361394 | 5360 | 64131973 |
Injection site extravasation | 16.08 | 9.79 | 13 | 361386 | 8073 | 64129260 |
Psychogenic tremor | 16.02 | 9.79 | 6 | 361393 | 22 | 64137311 |
Pruritus genital | 15.94 | 9.79 | 24 | 361375 | 1008 | 64136325 |
Benign familial pemphigus | 15.85 | 9.79 | 5 | 361394 | 9 | 64137324 |
Respiratory tract oedema | 15.83 | 9.79 | 20 | 361379 | 710 | 64136623 |
Meningoencephalitis bacterial | 15.81 | 9.79 | 11 | 361388 | 178 | 64137155 |
Food intolerance | 15.79 | 9.79 | 43 | 361356 | 2783 | 64134550 |
Febrile convulsion | 15.61 | 9.79 | 21 | 361378 | 794 | 64136539 |
Superficial vein prominence | 15.60 | 9.79 | 8 | 361391 | 71 | 64137262 |
Pharyngeal erythema | 15.54 | 9.79 | 32 | 361367 | 1727 | 64135606 |
Pulmonary alveolar haemorrhage | 15.52 | 9.79 | 19 | 361380 | 9719 | 64127614 |
Pneumatosis intestinalis | 15.46 | 9.79 | 5 | 361394 | 5224 | 64132109 |
Fusobacterium infection | 15.45 | 9.79 | 9 | 361390 | 105 | 64137228 |
Lung disorder | 15.43 | 9.79 | 243 | 361156 | 60457 | 64076876 |
Listless | 15.42 | 9.79 | 47 | 361352 | 3243 | 64134090 |
Dermatitis bullous | 15.38 | 9.79 | 118 | 361281 | 11936 | 64125397 |
Necrosis ischaemic | 15.38 | 9.79 | 23 | 361376 | 960 | 64136373 |
Colon cancer | 15.38 | 9.79 | 30 | 361369 | 12709 | 64124624 |
Neutrophil Pelger-Huet anomaly present | 15.38 | 9.79 | 14 | 361385 | 339 | 64136994 |
Enzyme induction | 15.38 | 9.79 | 9 | 361390 | 106 | 64137227 |
Spondylitis | 15.33 | 9.79 | 45 | 361354 | 3041 | 64134292 |
Glomerulonephropathy | 15.27 | 9.79 | 13 | 361386 | 287 | 64137046 |
Adenovirus infection | 15.27 | 9.79 | 11 | 361388 | 7244 | 64130089 |
Blood copper decreased | 15.20 | 9.79 | 5 | 361394 | 11 | 64137322 |
Bradypnoea | 15.13 | 9.79 | 5 | 361394 | 5154 | 64132179 |
Food craving | 15.13 | 9.79 | 28 | 361371 | 1396 | 64135937 |
Exposure during pregnancy | 15.04 | 9.79 | 326 | 361073 | 77349 | 64059984 |
Accidental overdose | 15.02 | 9.79 | 268 | 361131 | 33289 | 64104044 |
Asthenia | 15.01 | 9.79 | 2136 | 359263 | 425908 | 63711425 |
Tremor | 14.99 | 9.79 | 678 | 360721 | 147552 | 63989781 |
Inappropriate schedule of product administration | 14.93 | 9.79 | 398 | 361001 | 91888 | 64045445 |
Tympanic membrane hyperaemia | 14.90 | 9.79 | 5 | 361394 | 12 | 64137321 |
Portal vein phlebitis | 14.90 | 9.79 | 5 | 361394 | 12 | 64137321 |
Type I hypersensitivity | 14.87 | 9.79 | 49 | 361350 | 3525 | 64133808 |
Necrotising soft tissue infection | 14.86 | 9.79 | 11 | 361388 | 197 | 64137136 |
Rash macular | 14.75 | 9.79 | 200 | 361199 | 23485 | 64113848 |
Secondary amyloidosis | 14.68 | 9.79 | 9 | 361390 | 116 | 64137217 |
Therapy interrupted | 14.68 | 9.79 | 60 | 361339 | 19976 | 64117357 |
Klebsiella infection | 14.58 | 9.79 | 33 | 361366 | 13248 | 64124085 |
Angular cheilitis | 14.58 | 9.79 | 16 | 361383 | 488 | 64136845 |
Infected dermal cyst | 14.55 | 9.79 | 20 | 361379 | 772 | 64136561 |
Fear | 14.54 | 9.79 | 175 | 361224 | 19996 | 64117337 |
Drug withdrawal headache | 14.53 | 9.79 | 8 | 361391 | 83 | 64137250 |
Pemphigoid | 14.48 | 9.79 | 32 | 361367 | 12954 | 64124379 |
Hyperacusis | 14.46 | 9.79 | 33 | 361366 | 1912 | 64135421 |
Blood potassium increased | 14.31 | 9.79 | 86 | 361313 | 25894 | 64111439 |
Aortic bruit | 14.18 | 9.79 | 11 | 361388 | 212 | 64137121 |
Duodenitis haemorrhagic | 14.17 | 9.79 | 9 | 361390 | 124 | 64137209 |
Pyrexia | 14.10 | 9.79 | 2839 | 358560 | 555805 | 63581528 |
Vulvovaginitis trichomonal | 14.10 | 9.79 | 5 | 361394 | 15 | 64137318 |
Superior sagittal sinus thrombosis | 14.09 | 9.79 | 22 | 361377 | 954 | 64136379 |
Hyperammonaemia | 14.09 | 9.79 | 21 | 361378 | 9883 | 64127450 |
Accidental exposure to product by child | 14.08 | 9.79 | 38 | 361361 | 2447 | 64134886 |
Burn oral cavity | 14.06 | 9.79 | 7 | 361392 | 58 | 64137275 |
Blood bilirubin unconjugated | 14.01 | 9.79 | 4 | 361395 | 4 | 64137329 |
Swelling of eyelid | 13.94 | 9.79 | 35 | 361364 | 2157 | 64135176 |
Pneumoperitoneum | 13.92 | 9.79 | 40 | 361359 | 2671 | 64134662 |
Lung transplant | 13.91 | 9.79 | 3 | 361396 | 4105 | 64133228 |
Product storage error | 13.90 | 9.79 | 34 | 361365 | 13284 | 64124049 |
Asphyxia | 13.89 | 9.79 | 20 | 361379 | 9546 | 64127787 |
Alveolar rhabdomyosarcoma | 13.86 | 9.79 | 5 | 361394 | 16 | 64137317 |
Brain death | 13.84 | 9.79 | 59 | 361340 | 4802 | 64132531 |
Balance disorder | 13.82 | 9.79 | 361 | 361038 | 83565 | 64053768 |
Renal disorder | 13.79 | 9.79 | 129 | 361270 | 35236 | 64102097 |
Staphylococcal bacteraemia | 13.74 | 9.79 | 23 | 361376 | 10332 | 64127001 |
Generalised oedema | 13.73 | 9.79 | 65 | 361334 | 20788 | 64116545 |
Pneumonia bacterial | 13.72 | 9.79 | 41 | 361358 | 14994 | 64122339 |
Rhabdomyolysis | 13.71 | 9.79 | 400 | 360999 | 91326 | 64046007 |
Spinal compression fracture | 13.69 | 9.79 | 40 | 361359 | 14735 | 64122598 |
Immune reconstitution inflammatory syndrome | 13.68 | 9.79 | 31 | 361368 | 12439 | 64124894 |
Complication of device removal | 13.68 | 9.79 | 45 | 361354 | 3235 | 64134098 |
Escherichia sepsis | 13.66 | 9.79 | 12 | 361387 | 7153 | 64130180 |
Lymphopenia | 13.58 | 9.79 | 86 | 361313 | 25571 | 64111762 |
Scleroderma | 13.57 | 9.79 | 5 | 361394 | 4813 | 64132520 |
Sebaceous gland disorder | 13.53 | 9.79 | 6 | 361393 | 37 | 64137296 |
Bacterial infection | 13.53 | 9.79 | 83 | 361316 | 24867 | 64112466 |
Abscess rupture | 13.48 | 9.79 | 12 | 361387 | 282 | 64137051 |
Phonophobia | 13.47 | 9.79 | 15 | 361384 | 465 | 64136868 |
Transverse sinus thrombosis | 13.47 | 9.79 | 17 | 361382 | 603 | 64136730 |
Lymphoma | 13.47 | 9.79 | 37 | 361362 | 13904 | 64123429 |
Otitis media acute | 13.36 | 9.79 | 23 | 361376 | 1083 | 64136250 |
Angiocardiogram | 13.34 | 9.79 | 11 | 361388 | 232 | 64137101 |
Pulmonary function test decreased | 13.34 | 9.79 | 10 | 361389 | 6451 | 64130882 |
Mucosal necrosis | 13.33 | 9.79 | 8 | 361391 | 99 | 64137234 |
Conjunctival erosion | 13.33 | 9.79 | 8 | 361391 | 99 | 64137234 |
Erythema nodosum | 13.32 | 9.79 | 51 | 361348 | 3953 | 64133380 |
Large intestine perforation | 13.29 | 9.79 | 32 | 361367 | 12572 | 64124761 |
Herbal interaction | 13.26 | 9.79 | 14 | 361385 | 408 | 64136925 |
Paradoxical drug reaction | 13.25 | 9.79 | 9 | 361390 | 6111 | 64131222 |
Substance dependence | 13.22 | 9.79 | 15 | 361384 | 475 | 64136858 |
Condition aggravated | 13.22 | 9.79 | 1857 | 359542 | 370569 | 63766764 |
Exposure via partner | 13.21 | 9.79 | 5 | 361394 | 19 | 64137314 |
Alpha 1 microglobulin increased | 13.20 | 9.79 | 7 | 361392 | 67 | 64137266 |
Sleep disorder due to a general medical condition | 13.19 | 9.79 | 16 | 361383 | 8218 | 64129115 |
Hyperuricaemia | 13.19 | 9.79 | 23 | 361376 | 10168 | 64127165 |
Brain natriuretic peptide increased | 13.14 | 9.79 | 14 | 361385 | 7619 | 64129714 |
Microbiology test abnormal | 13.13 | 9.79 | 4 | 361395 | 6 | 64137327 |
Drug level decreased | 13.11 | 9.79 | 28 | 361371 | 11475 | 64125858 |
Palmar-plantar erythrodysaesthesia syndrome | 13.09 | 9.79 | 101 | 361298 | 28718 | 64108615 |
Nephrolithiasis | 13.08 | 9.79 | 329 | 361070 | 43354 | 64093979 |
Tuberculosis | 13.05 | 9.79 | 34 | 361365 | 13004 | 64124329 |
Oesophageal ulcer | 13.04 | 9.79 | 69 | 361330 | 6141 | 64131192 |
Cephalo-pelvic disproportion | 13.02 | 9.79 | 9 | 361390 | 144 | 64137189 |
Visual snow syndrome | 13.02 | 9.79 | 5 | 361394 | 20 | 64137313 |
COVID-19 pneumonia | 13.00 | 9.79 | 48 | 361351 | 16456 | 64120877 |
Cardiac arrest | 13.00 | 9.79 | 718 | 360681 | 153346 | 63983987 |
Vulval disorder | 12.99 | 9.79 | 15 | 361384 | 484 | 64136849 |
Pancreatic carcinoma | 12.90 | 9.79 | 24 | 361375 | 10349 | 64126984 |
Cardiac pacemaker insertion | 12.87 | 9.79 | 6 | 361393 | 5017 | 64132316 |
Necrotising fasciitis streptococcal | 12.86 | 9.79 | 9 | 361390 | 147 | 64137186 |
Status asthmaticus | 12.85 | 9.79 | 21 | 361378 | 947 | 64136386 |
Device dislocation | 12.85 | 9.79 | 178 | 361221 | 21000 | 64116333 |
Cerebellar syndrome | 12.84 | 9.79 | 6 | 361393 | 5010 | 64132323 |
Loss of control of legs | 12.82 | 9.79 | 29 | 361370 | 1670 | 64135663 |
Hypoglycaemic coma | 12.79 | 9.79 | 4 | 361395 | 4270 | 64133063 |
Polymenorrhagia | 12.78 | 9.79 | 6 | 361393 | 43 | 64137290 |
Ductus arteriosus stenosis foetal | 12.77 | 9.79 | 7 | 361392 | 72 | 64137261 |
Cholecystitis acute | 12.75 | 9.79 | 108 | 361291 | 11252 | 64126081 |
Osteomyelitis blastomyces | 12.75 | 9.79 | 4 | 361395 | 7 | 64137326 |
Oesophageal discomfort | 12.73 | 9.79 | 11 | 361388 | 248 | 64137085 |
Abnormal clotting factor | 12.73 | 9.79 | 8 | 361391 | 108 | 64137225 |
Subileus | 12.67 | 9.79 | 6 | 361393 | 4971 | 64132362 |
Crying | 12.65 | 9.79 | 170 | 361229 | 19920 | 64117413 |
Skin toxicity | 12.65 | 9.79 | 11 | 361388 | 6591 | 64130742 |
Exposure to toxic agent | 12.63 | 9.79 | 68 | 361331 | 6091 | 64131242 |
Mycoplasma test positive | 12.62 | 9.79 | 10 | 361389 | 199 | 64137134 |
Nerve injury | 12.62 | 9.79 | 80 | 361319 | 7605 | 64129728 |
Anastomotic ulcer perforation | 12.57 | 9.79 | 3 | 361396 | 0 | 64137333 |
Corrosive gastritis | 12.57 | 9.79 | 3 | 361396 | 0 | 64137333 |
Oculoauriculovertebral dysplasia | 12.57 | 9.79 | 3 | 361396 | 0 | 64137333 |
Vestibular ataxia | 12.57 | 9.79 | 3 | 361396 | 0 | 64137333 |
Ultrasound antenatal screen | 12.57 | 9.79 | 3 | 361396 | 0 | 64137333 |
Foetal non-stress test | 12.57 | 9.79 | 3 | 361396 | 0 | 64137333 |
Enterococcal infection | 12.52 | 9.79 | 38 | 361361 | 13828 | 64123505 |
Hepatic enzyme increased | 12.51 | 9.79 | 867 | 360532 | 129076 | 64008257 |
Temperature regulation disorder | 12.50 | 9.79 | 4 | 361395 | 4207 | 64133126 |
Therapy partial responder | 12.49 | 9.79 | 24 | 361375 | 10224 | 64127109 |
Mental disorder | 12.48 | 9.79 | 213 | 361186 | 26232 | 64111101 |
Anterior interosseous syndrome | 12.47 | 9.79 | 5 | 361394 | 23 | 64137310 |
Strawberry tongue | 12.47 | 9.79 | 5 | 361394 | 23 | 64137310 |
Lymphocyte count decreased | 12.44 | 9.79 | 157 | 361242 | 40542 | 64096791 |
Mycoplasma infection | 12.43 | 9.79 | 17 | 361382 | 653 | 64136680 |
Foreign body reaction | 12.42 | 9.79 | 8 | 361391 | 113 | 64137220 |
Small intestinal stenosis | 12.41 | 9.79 | 17 | 361382 | 654 | 64136679 |
Monoplegia | 12.41 | 9.79 | 45 | 361354 | 3398 | 64133935 |
Grief reaction | 12.41 | 9.79 | 11 | 361388 | 257 | 64137076 |
Product used for unknown indication | 12.39 | 9.79 | 19 | 361380 | 811 | 64136522 |
Fungaemia | 12.34 | 9.79 | 3 | 361396 | 3782 | 64133551 |
Neurosis | 12.31 | 9.79 | 13 | 361386 | 379 | 64136954 |
Status epilepticus | 12.31 | 9.79 | 71 | 361328 | 21592 | 64115741 |
Cholecystitis | 12.30 | 9.79 | 166 | 361233 | 19470 | 64117863 |
Enterocolitis | 12.29 | 9.79 | 31 | 361368 | 11987 | 64125346 |
Hepatitis B reactivation | 12.28 | 9.79 | 6 | 361393 | 4883 | 64132450 |
Left ventricular dysfunction | 12.28 | 9.79 | 51 | 361348 | 16903 | 64120430 |
Hypocoagulable state | 12.22 | 9.79 | 30 | 361369 | 1823 | 64135510 |
Tachycardia | 12.21 | 9.79 | 985 | 360414 | 148594 | 63988739 |
Blood pressure diastolic decreased | 12.19 | 9.79 | 74 | 361325 | 22227 | 64115106 |
Human papilloma virus test positive | 12.15 | 9.79 | 14 | 361385 | 451 | 64136882 |
Henoch-Schonlein purpura nephritis | 12.13 | 9.79 | 5 | 361394 | 25 | 64137308 |
Ear canal stenosis | 12.10 | 9.79 | 4 | 361395 | 9 | 64137324 |
Anion gap | 12.07 | 9.79 | 30 | 361369 | 1837 | 64135496 |
Benzodiazepine drug level increased | 12.05 | 9.79 | 10 | 361389 | 213 | 64137120 |
Heparin-induced thrombocytopenia | 12.04 | 9.79 | 18 | 361381 | 8461 | 64128872 |
Crepitations | 12.04 | 9.79 | 16 | 361383 | 7899 | 64129434 |
Glucose tolerance impaired | 12.03 | 9.79 | 11 | 361388 | 6432 | 64130901 |
Post cholecystectomy syndrome | 12.02 | 9.79 | 6 | 361393 | 50 | 64137283 |
Breath sounds abnormal | 12.01 | 9.79 | 30 | 361369 | 11639 | 64125694 |
Acidosis hyperchloraemic | 12.00 | 9.79 | 17 | 361382 | 675 | 64136658 |
Menstruation irregular | 12.00 | 9.79 | 53 | 361346 | 4382 | 64132951 |
Base excess | 11.99 | 9.79 | 7 | 361392 | 82 | 64137251 |
Purpura fulminans | 11.98 | 9.79 | 9 | 361390 | 165 | 64137168 |
Pituitary tumour benign | 11.94 | 9.79 | 34 | 361365 | 2259 | 64135074 |
Mediastinal abscess | 11.92 | 9.79 | 6 | 361393 | 51 | 64137282 |
Symmetrical drug-related intertriginous and flexural exanthema | 11.89 | 9.79 | 16 | 361383 | 605 | 64136728 |
Tubulointerstitial nephritis and uveitis syndrome | 11.86 | 9.79 | 11 | 361388 | 273 | 64137060 |
Injection site hyperaesthesia | 11.82 | 9.79 | 6 | 361393 | 52 | 64137281 |
Kawasaki's disease | 11.81 | 9.79 | 4 | 361395 | 10 | 64137323 |
Anti-transglutaminase antibody | 11.81 | 9.79 | 4 | 361395 | 10 | 64137323 |
Symblepharon | 11.75 | 9.79 | 9 | 361390 | 170 | 64137163 |
Pharyngeal oedema | 11.75 | 9.79 | 136 | 361263 | 15395 | 64121938 |
Anti-thyroid antibody positive | 11.74 | 9.79 | 14 | 361385 | 468 | 64136865 |
Orthostatic intolerance | 11.73 | 9.79 | 27 | 361372 | 1573 | 64135760 |
Product use issue | 11.73 | 9.79 | 713 | 360686 | 151002 | 63986331 |
Aortic stenosis | 11.73 | 9.79 | 11 | 361388 | 6354 | 64130979 |
Emphysema | 11.70 | 9.79 | 40 | 361359 | 14029 | 64123304 |
Uterine pain | 11.66 | 9.79 | 9 | 361390 | 172 | 64137161 |
Euglycaemic diabetic ketoacidosis | 11.66 | 9.79 | 8 | 361391 | 5402 | 64131931 |
Ileus | 11.64 | 9.79 | 78 | 361321 | 22888 | 64114445 |
Facet joint syndrome | 11.64 | 9.79 | 30 | 361369 | 1879 | 64135454 |
Haemoptysis | 11.59 | 9.79 | 199 | 361200 | 48849 | 64088484 |
Drug screen positive | 11.58 | 9.79 | 63 | 361336 | 5666 | 64131667 |
Thyroid stimulating immunoglobulin increased | 11.57 | 9.79 | 7 | 361392 | 88 | 64137245 |
Pyloric stenosis | 11.55 | 9.79 | 13 | 361386 | 408 | 64136925 |
Speech sound disorder | 11.53 | 9.79 | 6 | 361393 | 55 | 64137278 |
Linear IgA disease | 11.51 | 9.79 | 38 | 361361 | 2736 | 64134597 |
Pelvic adhesions | 11.50 | 9.79 | 11 | 361388 | 284 | 64137049 |
Conjunctival scar | 11.50 | 9.79 | 7 | 361392 | 89 | 64137244 |
Genital ulceration | 11.46 | 9.79 | 16 | 361383 | 627 | 64136706 |
Lower gastrointestinal haemorrhage | 11.43 | 9.79 | 124 | 361275 | 13815 | 64123518 |
Interleukin level increased | 11.42 | 9.79 | 13 | 361386 | 413 | 64136920 |
Renal cancer | 11.40 | 9.79 | 13 | 361386 | 6862 | 64130471 |
pH body fluid decreased | 11.39 | 9.79 | 5 | 361394 | 30 | 64137303 |
Acute haemorrhagic oedema of infancy | 11.35 | 9.79 | 6 | 361393 | 57 | 64137276 |
Upper gastrointestinal perforation | 11.28 | 9.79 | 4 | 361395 | 12 | 64137321 |
Schizophrenia | 11.27 | 9.79 | 29 | 361370 | 11139 | 64126194 |
Human herpesvirus 6 infection | 11.26 | 9.79 | 6 | 361393 | 4648 | 64132685 |
Eye disorder | 11.21 | 9.79 | 158 | 361241 | 18711 | 64118622 |
Urinary retention | 11.19 | 9.79 | 201 | 361198 | 49000 | 64088333 |
Tension headache | 11.18 | 9.79 | 43 | 361356 | 3340 | 64133993 |
Skin irritation | 11.18 | 9.79 | 89 | 361310 | 9105 | 64128228 |
Mania | 11.18 | 9.79 | 50 | 361349 | 16236 | 64121097 |
Prescription drug used without a prescription | 11.14 | 9.79 | 36 | 361363 | 2564 | 64134769 |
Blood prolactin increased | 11.11 | 9.79 | 3 | 361396 | 3525 | 64133808 |
Inadequate analgesia | 11.11 | 9.79 | 48 | 361351 | 3930 | 64133403 |
Intestinal cyst | 11.11 | 9.79 | 8 | 361391 | 137 | 64137196 |
Muscle tightness | 11.10 | 9.79 | 103 | 361296 | 11012 | 64126321 |
Skin necrosis | 11.07 | 9.79 | 126 | 361273 | 14203 | 64123130 |
Gastric cancer | 11.07 | 9.79 | 12 | 361387 | 6481 | 64130852 |
Skin papilloma | 11.05 | 9.79 | 58 | 361341 | 5145 | 64132188 |
Pathological fracture | 11.05 | 9.79 | 21 | 361378 | 8984 | 64128349 |
Normochromic anaemia | 11.03 | 9.79 | 13 | 361386 | 429 | 64136904 |
Catheter site haemorrhage | 10.99 | 9.79 | 6 | 361393 | 4585 | 64132748 |
Bladder neck obstruction | 10.98 | 9.79 | 7 | 361392 | 97 | 64137236 |
Increased upper airway secretion | 10.98 | 9.79 | 44 | 361355 | 3483 | 64133850 |
Varicella | 10.97 | 9.79 | 36 | 361363 | 2585 | 64134748 |
Tissue infiltration | 10.93 | 9.79 | 15 | 361384 | 578 | 64136755 |
Gait deviation | 10.92 | 9.79 | 6 | 361393 | 62 | 64137271 |
Osteosclerosis | 10.91 | 9.79 | 3 | 361396 | 3483 | 64133850 |
Nasal pruritus | 10.88 | 9.79 | 12 | 361387 | 368 | 64136965 |
Antineutrophil cytoplasmic antibody | 10.87 | 9.79 | 5 | 361394 | 34 | 64137299 |
Delusion | 10.80 | 9.79 | 58 | 361341 | 17956 | 64119377 |
Atrioventricular block | 10.80 | 9.79 | 33 | 361366 | 11982 | 64125351 |
Cystitis | 10.79 | 9.79 | 171 | 361228 | 42504 | 64094829 |
Device breakage | 10.78 | 9.79 | 85 | 361314 | 8670 | 64128663 |
Catheterisation cardiac | 10.78 | 9.79 | 7 | 361392 | 4866 | 64132467 |
Complication of device insertion | 10.73 | 9.79 | 56 | 361343 | 4956 | 64132377 |
Epiglottitis | 10.72 | 9.79 | 16 | 361383 | 667 | 64136666 |
Reaction to excipient | 10.65 | 9.79 | 24 | 361375 | 1379 | 64135954 |
Blood test abnormal | 10.62 | 9.79 | 37 | 361362 | 12906 | 64124427 |
Myeloma cast nephropathy | 10.59 | 9.79 | 8 | 361391 | 148 | 64137185 |
Osteonecrosis | 10.57 | 9.79 | 104 | 361295 | 28125 | 64109208 |
Streptococcal infection | 10.56 | 9.79 | 75 | 361324 | 7404 | 64129929 |
Cystoscopy abnormal | 10.51 | 9.79 | 3 | 361396 | 3 | 64137330 |
Circumoral swelling | 10.51 | 9.79 | 3 | 361396 | 3 | 64137330 |
Vertebral artery hypoplasia | 10.51 | 9.79 | 3 | 361396 | 3 | 64137330 |
Tongue injury | 10.49 | 9.79 | 11 | 361388 | 318 | 64137015 |
Blood calcium decreased | 10.49 | 9.79 | 92 | 361307 | 25462 | 64111871 |
Gastrointestinal perforation | 10.44 | 9.79 | 9 | 361390 | 5415 | 64131918 |
Wrong patient received product | 10.43 | 9.79 | 4 | 361395 | 3758 | 64133575 |
Nuchal rigidity | 10.43 | 9.79 | 19 | 361380 | 936 | 64136397 |
Hyperhidrosis | 10.42 | 9.79 | 824 | 360575 | 124096 | 64013237 |
Peritonsillitis | 10.40 | 9.79 | 5 | 361394 | 38 | 64137295 |
Staphylococcal scalded skin syndrome | 10.38 | 9.79 | 12 | 361387 | 388 | 64136945 |
Escherichia bacteraemia | 10.36 | 9.79 | 9 | 361390 | 5394 | 64131939 |
Thrombophlebitis septic | 10.35 | 9.79 | 11 | 361388 | 323 | 64137010 |
Drug ineffective for unapproved indication | 10.32 | 9.79 | 118 | 361281 | 31015 | 64106318 |
Postoperative wound infection | 10.31 | 9.79 | 27 | 361372 | 10309 | 64127024 |
Subacute hepatic failure | 10.30 | 9.79 | 9 | 361390 | 206 | 64137127 |
Haemorrhoids thrombosed | 10.30 | 9.79 | 9 | 361390 | 206 | 64137127 |
Catheter site infection | 10.30 | 9.79 | 10 | 361389 | 5683 | 64131650 |
Catheter management | 10.29 | 9.79 | 3 | 361396 | 3352 | 64133981 |
Maternal exposure timing unspecified | 10.29 | 9.79 | 36 | 361363 | 2671 | 64134662 |
Thrombosis in device | 10.28 | 9.79 | 8 | 361391 | 5063 | 64132270 |
Vulvitis | 10.27 | 9.79 | 9 | 361390 | 207 | 64137126 |
Hypothyroidism | 10.27 | 9.79 | 162 | 361237 | 40295 | 64097038 |
Viral mutation identified | 10.25 | 9.79 | 3 | 361396 | 3343 | 64133990 |
Bradykinesia | 10.25 | 9.79 | 13 | 361386 | 6547 | 64130786 |
Hypoaesthesia | 10.24 | 9.79 | 909 | 360490 | 138199 | 63999134 |
Scleral oedema | 10.22 | 9.79 | 4 | 361395 | 17 | 64137316 |
Spinal pain | 10.22 | 9.79 | 112 | 361287 | 12509 | 64124824 |
Respiratory fatigue | 10.20 | 9.79 | 9 | 361390 | 209 | 64137124 |
Drug eruption | 10.19 | 9.79 | 270 | 361129 | 35866 | 64101467 |
Lip erythema | 10.19 | 9.79 | 8 | 361391 | 157 | 64137176 |
Basal ganglion degeneration | 10.18 | 9.79 | 12 | 361387 | 396 | 64136937 |
Cognitive disorder | 10.15 | 9.79 | 233 | 361166 | 54854 | 64082479 |
Xanthelasma | 10.15 | 9.79 | 8 | 361391 | 158 | 64137175 |
Pneumonia klebsiella | 10.07 | 9.79 | 5 | 361394 | 4032 | 64133301 |
Effusion | 10.07 | 9.79 | 29 | 361370 | 1939 | 64135394 |
Akathisia | 10.07 | 9.79 | 32 | 361367 | 11478 | 64125855 |
Empyema | 10.07 | 9.79 | 44 | 361355 | 3621 | 64133712 |
Thrombosis prophylaxis | 10.04 | 9.79 | 4 | 361395 | 18 | 64137315 |
Protein urine present | 10.04 | 9.79 | 22 | 361377 | 8934 | 64128399 |
Agranulocytosis | 10.03 | 9.79 | 283 | 361116 | 37946 | 64099387 |
Erysipelas | 10.02 | 9.79 | 86 | 361313 | 8995 | 64128338 |
Choluria | 10.01 | 9.79 | 11 | 361388 | 336 | 64136997 |
Cerebral atrophy | 9.84 | 9.79 | 16 | 361383 | 7269 | 64130064 |
Stent placement | 9.83 | 9.79 | 10 | 361389 | 5561 | 64131772 |
White blood cell count increased | 9.83 | 9.79 | 288 | 361111 | 65726 | 64071607 |
Joint injury | 9.82 | 9.79 | 182 | 361217 | 22765 | 64114568 |
Chondromalacia | 9.81 | 9.79 | 8 | 361391 | 166 | 64137167 |
Transaminases | 9.81 | 9.79 | 6 | 361393 | 77 | 64137256 |
Allodynia | 9.80 | 9.79 | 22 | 361377 | 1261 | 64136072 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intestinal perforation | 51.41 | 25.43 | 21 | 702 | 61 | 83894 |
Oliguria | 34.00 | 25.43 | 9 | 714 | 0 | 83955 |
Intraventricular haemorrhage | 30.61 | 25.43 | 18 | 705 | 136 | 83819 |
Product use in unapproved indication | 30.00 | 25.43 | 10 | 713 | 12 | 83943 |
Product use issue | 29.41 | 25.43 | 16 | 707 | 102 | 83853 |
Pulmonary arterial hypertension | 27.30 | 25.43 | 10 | 713 | 19 | 83936 |
Source | Code | Description |
---|---|---|
ATC | C01EB16 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY OTHER CARDIAC PREPARATIONS Other cardiac preparations |
ATC | G02CC01 | GENITO URINARY SYSTEM AND SEX HORMONES OTHER GYNECOLOGICALS OTHER GYNECOLOGICALS Antiinflammatory products for vaginal administration |
ATC | M01AE01 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
ATC | M01AE51 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
ATC | M02AA13 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
ATC | N02AJ08 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
ATC | N02AJ19 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
ATC | R02AX02 | RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Other throat preparations |
FDA CS | M0001335 | Anti-Inflammatory Agents, Non-Steroidal |
FDA MoA | N0000000160 | Cyclooxygenase Inhibitors |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D016861 | Cyclooxygenase Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
CHEBI has role | CHEBI:35493 | anti-pyretic |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:48578 | free radical scavengers |
CHEBI has role | CHEBI:50629 | COX-2 inhibitor |
CHEBI has role | CHEBI:50630 | COX-1 inhibitor |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
CHEBI has role | CHEBI:176497 | geroprotectors |
FDA EPC | N0000175722 | Nonsteroidal Anti-inflammatory Drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Sinus headache | indication | 4969004 | |
Pain | indication | 22253000 | |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Severe pain | indication | 76948002 | |
Patent ductus arteriosus | indication | 83330001 | DOID:13832 |
Headache disorder | indication | 230461009 | |
Dysmenorrhea | indication | 266599000 | |
Influenza-like symptoms | indication | 315642008 | |
Fever | indication | 386661006 | |
Osteoarthritis | indication | 396275006 | |
Juvenile rheumatoid arthritis | indication | 410795001 | |
Acute postoperative pain | indication | 107401000119105 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Suicidal thoughts | contraindication | 6471006 | |
Dependent drug abuse | contraindication | 6525002 | |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Asthenia | contraindication | 13791008 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Mood swings | contraindication | 18963009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Alcohol intoxication | contraindication | 25702006 | |
Shock | contraindication | 27942005 | |
Hypercapnia | contraindication | 29596007 | |
Dehydration | contraindication | 34095006 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Hypokalemia | contraindication | 43339004 | |
Body fluid retention | contraindication | 43498006 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Gastrointestinal perforation | contraindication | 51875005 | |
Gastrectomy | contraindication | 53442002 | |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Leber's optic atrophy | contraindication | 58610003 | DOID:705 |
Hepatic failure | contraindication | 59927004 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Agoraphobia | contraindication | 70691001 | DOID:593 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Urethral stricture | contraindication | 76618002 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
Pulmonary emphysema | contraindication | 87433001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Acute abdominal pain | contraindication | 116290004 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
Impaired renal function disorder | contraindication | 197663003 | |
Cerebrovascular accident | contraindication | 230690007 | |
Coronary artery bypass graft | contraindication | 232717009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Morbid obesity | contraindication | 238136002 | DOID:11981 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Exacerbation of asthma | contraindication | 281239006 | |
Pregnancy, function | contraindication | 289908002 | |
Lesion of brain | contraindication | 301766008 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Thromboembolic disorder | contraindication | 371039008 | |
Panic disorder | contraindication | 371631005 | DOID:594 |
Coma | contraindication | 371632003 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Operation on gastrointestinal tract | contraindication | 386621005 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Cardiovascular event risk | contraindication | 395112001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Central nervous system depression | contraindication | 418072004 | |
Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
Hypertensive urgency | contraindication | 443482000 | |
Smokes tobacco daily | contraindication | 449868002 | |
Significant Bleeding | contraindication | ||
Acute Thromboembolic Stroke | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.37 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
25MG;EQ 200MG FREE ACID AND POTASSIUM SALT | ADVIL PM | GLAXOSMITHKLINE | N021393 | Dec. 21, 2005 | OTC | CAPSULE | ORAL | 8883849 | Jan. 17, 2022 | A METHOD OF TREATING A PATIENT SUFFERING FROM A PAIN ASSOCIATED SLEEP DISTURBANCE COMPRISING ADMINISTERING A LIQUID COMPOSITION FORMULATED INSIDE A SOFT GEL CAPSULE, AS CLAIMED, TO THE PATIENT |
26.6MG;800MG | DUEXIS | HORIZON | N022519 | April 23, 2011 | RX | TABLET | ORAL | 8067451 | July 18, 2026 | RELIEF OF SIGNS AND SYMPTOMS OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS AND TO DECREASE RISK OF DEVELOPING UPPER GASTROINTESTINAL ULCERS IN PATIENTS WHO ARE TAKING IBUPROFEN FOR THOSE INDICATIONS |
26.6MG;800MG | DUEXIS | HORIZON | N022519 | April 23, 2011 | RX | TABLET | ORAL | 8501228 | July 18, 2026 | RELIEF OF SIGNS AND SYMPTOMS OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS AND TO DECREASE RISK OF DEVELOPING UPPER GASTROINTESTINAL ULCERS IN PATIENTS WHO ARE TAKING IBUPROFEN FOR THOSE INDICATIONS |
800MG/200ML (4MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | Jan. 25, 2019 | RX | SOLUTION | INTRAVENOUS | 8735452 | Sept. 30, 2029 | MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY |
800MG/200ML (4MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | Jan. 25, 2019 | RX | SOLUTION | INTRAVENOUS | 8871810 | Sept. 30, 2029 | MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY |
800MG/8ML (100MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | June 11, 2009 | RX | SOLUTION | INTRAVENOUS | 8735452 | Sept. 30, 2029 | MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY |
800MG/8ML (100MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | June 11, 2009 | RX | SOLUTION | INTRAVENOUS | 8871810 | Sept. 30, 2029 | MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY |
800MG/8ML (100MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | June 11, 2009 | RX | SOLUTION | INTRAVENOUS | 9114068 | Sept. 30, 2029 | METHODS OF TREATING PAIN, INFLAMMATION AND/OR FEVER WITH INTRAVENOUS IBUPROFEN SUCH THAT MEAN ARTERIAL BLOOD PRESSURE DOES NOT INCREASE THE DOSAGE INTERVAL |
800MG/8ML (100MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | June 11, 2009 | RX | SOLUTION | INTRAVENOUS | 9138404 | Sept. 30, 2029 | METHODS OF TREATING PAIN, INFLAMMATION AND/OR FEVER IN A CRITICALLY ILL PATIENT WITH INTRAVENOUS IBUPROFEN IN NEED THEREOF |
800MG/8ML (100MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | June 11, 2009 | RX | SOLUTION | INTRAVENOUS | 9295639 | Sept. 30, 2029 | METHODS OF TREATING PAIN, INFLAMMATION AND/OR FEVER IN A CRITICALLY ILL PATIENT WITH INTRAVENOUS IBUPROFEN IN NEED THEREOF |
800MG/8ML (100MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | June 11, 2009 | RX | SOLUTION | INTRAVENOUS | 9649284 | Sept. 30, 2029 | MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS IN A CRITICALLY ILL PATIENT WITH INTRAVENOUS IBUPROFEN IN NEED THEREOF |
800MG/200ML (4MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | Jan. 25, 2019 | RX | SOLUTION | INTRAVENOUS | 9012508 | Sept. 14, 2030 | MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY |
800MG/8ML (100MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | June 11, 2009 | RX | SOLUTION | INTRAVENOUS | 9012508 | Sept. 14, 2030 | MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY |
800MG/200ML (4MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | Jan. 25, 2019 | RX | SOLUTION | INTRAVENOUS | 9072661 | March 16, 2032 | METHODS OF TREATING PAIN, INFLAMMATION, FEVER, PATENT DUCTUS ARTERIOSIS WITH AQUEOUS COMPOSITION |
800MG/200ML (4MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | Jan. 25, 2019 | RX | SOLUTION | INTRAVENOUS | 9072710 | March 16, 2032 | METHODS OF MAKING AQUEOUS COMPOSITION AND TREATING PAIN, INFLAMMATION, FEVER, PATENT DUCTUS ARTERIOSIS WITH AQUEOUS COMPOSITION |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
250MG;125MG | ADVIL DUAL ACTION WITH ACETAMINOPHEN | GLAXOSMITHKLINE | N211733 | Feb. 28, 2020 | OTC | TABLET | ORAL | Feb. 28, 2023 | NEW PRODUCT |
400MG/4ML (100MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | June 11, 2009 | DISCN | SOLUTION | INTRAVENOUS | Nov. 19, 2024 | CLINICAL TRIAL STUDY RESULTS |
800MG/200ML (4MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | Jan. 25, 2019 | RX | SOLUTION | INTRAVENOUS | Nov. 19, 2024 | CLINICAL TRIAL STUDY RESULTS |
800MG/8ML (100MG/ML) | CALDOLOR | CUMBERLAND PHARMS | N022348 | June 11, 2009 | RX | SOLUTION | INTRAVENOUS | Nov. 19, 2024 | CLINICAL TRIAL STUDY RESULTS |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 5.14 | WOMBAT-PK | CHEMBL | |||
Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 5.12 | WOMBAT-PK | CHEMBL | |||
Cytochrome P450 2C9 | Enzyme | Ki | 4.30 | WOMBAT-PK | |||||
Aldo-keto reductase family 1 member C2 | Enzyme | IC50 | 4.37 | CHEMBL | |||||
Aldo-keto reductase family 1 member C3 | Enzyme | IC50 | 4.48 | CHEMBL | |||||
Arachidonate 5-lipoxygenase | Enzyme | WOMBAT-PK | |||||||
Interleukin-8 | Cytokine | IC50 | 7.30 | CHEMBL | |||||
Sodium-coupled monocarboxylate transporter 1 | Transporter | INHIBITOR | IC50 | 4.20 | IUPHAR | ||||
Acid-sensing ion channel 1 | Ion channel | BLOCKER | IC50 | 3.53 | SCIENTIFIC LITERATURE | ||||
Fatty acid-binding protein, liver | Unclassified | Ki | 4.32 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.07 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | Ki | 5.05 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 5.96 | CHEMBL | |||||
Prostaglandin-H2 D-isomerase | Enzyme | IC50 | 4.89 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | Ki | 5.05 | CHEMBL | |||||
Serum albumin | Secreted | IC50 | 5.52 | CHEMBL | |||||
Solute carrier family 22 member 6 | Transporter | Ki | 5.33 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 5.54 | CHEMBL | |||||
Solute carrier family 22 member 20 | Transporter | Ki | 5.96 | CHEMBL | |||||
Cyclooxygenase | Enzyme | IC50 | 5.70 | CHEMBL | |||||
Dehydrogenase/reductase SDR family member 9 | Enzyme | IC50 | 4 | CHEMBL |
ID | Source |
---|---|
4032936 | VUID |
N0000189536 | NUI |
D00126 | KEGG_DRUG |
57469-77-9 | SECONDARY_CAS_RN |
527688-20-6 | SECONDARY_CAS_RN |
4017840 | VANDF |
4032936 | VANDF |
C0020740 | UMLSCUI |
CHEBI:132922 | CHEBI |
IBP | PDB_CHEM_ID |
CHEMBL427526 | ChEMBL_ID |
CHEMBL521 | ChEMBL_ID |
DB01050 | DRUGBANK_ID |
CHEMBL1201141 | ChEMBL_ID |
CHEMBL175 | ChEMBL_ID |
D007052 | MESH_DESCRIPTOR_UI |
3672 | PUBCHEM_CID |
2118 | INN_ID |
C016106 | MESH_SUPPLEMENTAL_RECORD_UI |
2713 | IUPHAR_LIGAND_ID |
WK2XYI10QM | UNII |
1429044 | RXNORM |
2133 | MMSL |
240518 | MMSL |
32273 | MMSL |
4862 | MMSL |
7027 | MMSL |
82565 | MMSL |
d00015 | MMSL |
002377 | NDDF |
006088 | NDDF |
006232 | NDDF |
38268001 | SNOMEDCT_US |
387207008 | SNOMEDCT_US |
425516000 | SNOMEDCT_US |
725863000 | SNOMEDCT_US |
CHEMBL3989408 | ChEMBL_ID |
CHEMBL1241153 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ibuprofen and famotidine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-8107 | TABLET, FILM COATED | 800 mg | ORAL | ANDA | 28 sections |
good sense ibuprofen pm | HUMAN OTC DRUG LABEL | 2 | 0113-0050 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
Good Sense ibuprofeninfants | HUMAN OTC DRUG LABEL | 1 | 0113-0057 | SUSPENSION | 50 mg | ORAL | ANDA | 15 sections |
Good Sense ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-0074 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
good sense ibuprofenchildrens | HUMAN OTC DRUG LABEL | 1 | 0113-0166 | SUSPENSION | 100 mg | ORAL | ANDA | 15 sections |
good sense ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-0298 | CAPSULE, LIQUID FILLED | 200 mg | ORAL | ANDA | 16 sections |
Good Sense ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-0517 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
Good Sense ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-0517 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
good sense ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-0604 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
good sense ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-0647 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
Good Sense IbuprofenChildrens | HUMAN OTC DRUG LABEL | 1 | 0113-0660 | SUSPENSION | 100 mg | ORAL | ANDA | 15 sections |
Good Sense Ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-0685 | SUSPENSION | 100 mg | ORAL | ANDA | 15 sections |
good sense ibuprofenchildrens | HUMAN OTC DRUG LABEL | 1 | 0113-0897 | SUSPENSION | 100 mg | ORAL | ANDA | 15 sections |
Good Sense Ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-1212 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
basic care childrens ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-1461 | TABLET, CHEWABLE | 100 mg | ORAL | ANDA | 15 sections |
Good Sense Childrens Ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-2461 | TABLET, CHEWABLE | 100 mg | ORAL | ANDA | 15 sections |
good sense ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-4501 | CAPSULE, LIQUID FILLED | 200 mg | ORAL | ANDA | 16 sections |
basic care ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-7131 | CAPSULE, LIQUID FILLED | 200 mg | ORAL | ANDA | 16 sections |
basic care ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-7517 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
Basic Care Ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-7604 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 16 sections |
basic care childrens ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-7660 | SUSPENSION | 100 mg | ORAL | ANDA | 15 sections |
Basic Care childrens ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0113-7897 | SUSPENSION | 100 mg | ORAL | ANDA | 15 sections |
Childrens Ibuprofen Oral Suspension | HUMAN OTC DRUG LABEL | 1 | 0121-0914 | SUSPENSION | 100 mg | ORAL | ANDA | 16 sections |
Childrens Ibuprofen Oral Suspension | HUMAN OTC DRUG LABEL | 1 | 0121-0914 | SUSPENSION | 100 mg | ORAL | ANDA | 16 sections |
Childrens Ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0121-0917 | SUSPENSION | 100 mg | ORAL | ANDA | 15 sections |
Ibuprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0918 | SUSPENSION | 100 mg | ORAL | ANDA | 27 sections |
IBUPROFEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1548 | SUSPENSION | 100 mg | ORAL | ANDA | 28 sections |
Childrens Ibuprofen Oral Suspension | HUMAN OTC DRUG LABEL | 1 | 0121-1828 | SUSPENSION | 100 mg | ORAL | ANDA | 16 sections |
Childrens Ibuprofen Oral Suspension | HUMAN OTC DRUG LABEL | 1 | 0121-1828 | SUSPENSION | 100 mg | ORAL | ANDA | 16 sections |
Childrens Ibuprofen | HUMAN OTC DRUG LABEL | 1 | 0121-1836 | SUSPENSION | 100 mg | ORAL | ANDA | 16 sections |