Stem definition | Drug id | CAS RN |
---|---|---|
analgesics | 2711 | 27203-92-5 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
0.30 | g | P |
0.30 | g | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 20 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 16.27 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 72.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.80 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 6.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.80 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
March 3, 1995 | FDA | JANSSEN PHARMS | |
Sept. 25, 2020 | PMDA | NIPPON ZOKI PHARMACEUTICAL CO., LTD. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 776.44 | 9.48 | 702 | 217167 | 27980 | 63243173 |
Drug dependence | 697.88 | 9.48 | 617 | 217252 | 23866 | 63247287 |
Drug abuse | 643.84 | 9.48 | 1002 | 216867 | 71516 | 63199637 |
Poisoning deliberate | 605.83 | 9.48 | 413 | 217456 | 10805 | 63260348 |
Toxicity to various agents | 601.39 | 9.48 | 2040 | 215829 | 245210 | 63025943 |
Pemphigus | 427.75 | 9.48 | 61 | 217808 | 183665 | 63087488 |
Drug hypersensitivity | 420.56 | 9.48 | 2141 | 215728 | 308546 | 62962607 |
Completed suicide | 403.28 | 9.48 | 1257 | 216612 | 144416 | 63126737 |
Coma | 323.09 | 9.48 | 695 | 217174 | 63669 | 63207484 |
Glossodynia | 322.26 | 9.48 | 106 | 217763 | 178770 | 63092383 |
Hand deformity | 315.80 | 9.48 | 79 | 217790 | 159378 | 63111775 |
Systemic lupus erythematosus | 310.24 | 9.48 | 165 | 217704 | 208753 | 63062400 |
Contraindicated product administered | 296.14 | 9.48 | 191 | 217678 | 217457 | 63053696 |
Intentional overdose | 289.06 | 9.48 | 725 | 217144 | 73427 | 63197726 |
Somnolence | 271.81 | 9.48 | 1274 | 216595 | 177411 | 63093742 |
Withdrawal syndrome | 255.47 | 9.48 | 329 | 217540 | 19668 | 63251485 |
Deafness transitory | 255.24 | 9.48 | 128 | 217741 | 1842 | 63269311 |
Bradypnoea | 254.01 | 9.48 | 156 | 217713 | 3394 | 63267759 |
Prescription form tampering | 251.54 | 9.48 | 89 | 217780 | 489 | 63270664 |
Overdose | 241.02 | 9.48 | 905 | 216964 | 114173 | 63156980 |
Infusion related reaction | 238.64 | 9.48 | 295 | 217574 | 245226 | 63025927 |
Pericarditis | 231.67 | 9.48 | 81 | 217788 | 131498 | 63139655 |
Maternal exposure during pregnancy | 230.49 | 9.48 | 249 | 217620 | 219813 | 63051340 |
Drug interaction | 218.58 | 9.48 | 1440 | 216429 | 227691 | 63043462 |
Gastrointestinal pain | 214.32 | 9.48 | 213 | 217656 | 9563 | 63261590 |
Synovitis | 212.33 | 9.48 | 197 | 217672 | 186721 | 63084432 |
Treatment failure | 212.03 | 9.48 | 222 | 217647 | 198821 | 63072332 |
Alopecia | 210.16 | 9.48 | 536 | 217333 | 337000 | 62934153 |
Drug withdrawal syndrome | 206.14 | 9.48 | 350 | 217519 | 26844 | 63244309 |
Anti-cyclic citrullinated peptide antibody positive | 202.08 | 9.48 | 73 | 217796 | 116139 | 63155014 |
Drug intolerance | 192.22 | 9.48 | 490 | 217379 | 308171 | 62962982 |
Wound | 190.26 | 9.48 | 168 | 217701 | 163095 | 63108058 |
Drug use disorder | 186.36 | 9.48 | 147 | 217722 | 4837 | 63266316 |
Drug ineffective | 185.18 | 9.48 | 2504 | 215365 | 1042261 | 62228892 |
Sensitisation | 178.87 | 9.48 | 123 | 217746 | 3263 | 63267890 |
Joint swelling | 167.88 | 9.48 | 570 | 217299 | 327096 | 62944057 |
Hepatic enzyme increased | 167.82 | 9.48 | 272 | 217597 | 202056 | 63069097 |
Discomfort | 165.82 | 9.48 | 198 | 217671 | 167176 | 63103977 |
Off label use | 165.44 | 9.48 | 1500 | 216369 | 672962 | 62598191 |
Miosis | 164.51 | 9.48 | 162 | 217707 | 7191 | 63263962 |
Respiratory depression | 158.74 | 9.48 | 215 | 217654 | 13500 | 63257653 |
Mydriasis | 157.90 | 9.48 | 200 | 217669 | 11756 | 63259397 |
Polycystic ovaries | 152.58 | 9.48 | 125 | 217744 | 4346 | 63266807 |
Ejection fraction | 147.80 | 9.48 | 96 | 217773 | 2310 | 63268843 |
Helicobacter infection | 142.51 | 9.48 | 70 | 217799 | 92715 | 63178438 |
Rheumatoid factor positive | 141.75 | 9.48 | 56 | 217813 | 84350 | 63186803 |
Therapeutic product effect decreased | 140.23 | 9.48 | 282 | 217587 | 192905 | 63078248 |
Duodenal ulcer perforation | 139.80 | 9.48 | 62 | 217807 | 87147 | 63184006 |
Intentional product misuse | 125.72 | 9.48 | 477 | 217392 | 60440 | 63210713 |
Hepatocellular injury | 125.28 | 9.48 | 285 | 217584 | 27096 | 63244057 |
Suicide attempt | 120.80 | 9.48 | 471 | 217398 | 60447 | 63210706 |
Rash | 120.27 | 9.48 | 1288 | 216581 | 559583 | 62711570 |
Exposure during pregnancy | 107.01 | 9.48 | 234 | 217635 | 155313 | 63115840 |
Arthropathy | 104.14 | 9.48 | 433 | 217436 | 234359 | 63036794 |
Product use issue | 103.94 | 9.48 | 397 | 217472 | 220123 | 63051030 |
Abdominal discomfort | 103.76 | 9.48 | 660 | 217209 | 320225 | 62950928 |
Shoulder arthroplasty | 102.48 | 9.48 | 95 | 217774 | 3907 | 63267246 |
Fall | 101.88 | 9.48 | 1901 | 215968 | 390433 | 62880720 |
Vomiting | 101.10 | 9.48 | 2573 | 215296 | 557044 | 62714109 |
Blood test abnormal | 100.23 | 9.48 | 187 | 217682 | 15442 | 63255711 |
Pharyngitis | 97.01 | 9.48 | 214 | 217655 | 19929 | 63251224 |
Muscle injury | 94.86 | 9.48 | 53 | 217816 | 65292 | 63205861 |
Rhinitis allergic | 88.95 | 9.48 | 151 | 217718 | 11576 | 63259577 |
Swelling | 88.69 | 9.48 | 567 | 217302 | 274811 | 62996342 |
Hallucination | 81.11 | 9.48 | 388 | 217481 | 54429 | 63216724 |
Carpal tunnel syndrome | 80.49 | 9.48 | 203 | 217666 | 20614 | 63250539 |
Folliculitis | 79.90 | 9.48 | 74 | 217795 | 70243 | 63200910 |
Derealisation | 78.65 | 9.48 | 50 | 217819 | 1158 | 63269995 |
Device expulsion | 77.99 | 9.48 | 13 | 217856 | 34909 | 63236244 |
Functional gastrointestinal disorder | 77.52 | 9.48 | 84 | 217785 | 4175 | 63266978 |
Dependence | 74.96 | 9.48 | 60 | 217809 | 2017 | 63269136 |
Cholestasis | 74.93 | 9.48 | 247 | 217622 | 29187 | 63241966 |
Sleep apnoea syndrome | 71.96 | 9.48 | 242 | 217627 | 28891 | 63242262 |
Impaired healing | 71.55 | 9.48 | 153 | 217716 | 102389 | 63168764 |
Depersonalisation/derealisation disorder | 70.50 | 9.48 | 49 | 217820 | 1323 | 63269830 |
Nausea | 68.80 | 9.48 | 3585 | 214284 | 850886 | 62420267 |
Asphyxia | 67.17 | 9.48 | 94 | 217775 | 6087 | 63265066 |
Generalised tonic-clonic seizure | 66.41 | 9.48 | 235 | 217634 | 28781 | 63242372 |
Cardio-respiratory arrest | 64.58 | 9.48 | 389 | 217480 | 59570 | 63211583 |
Red blood cell sedimentation rate increased | 63.36 | 9.48 | 36 | 217833 | 43946 | 63227207 |
Abnormal loss of weight | 62.93 | 9.48 | 88 | 217781 | 5694 | 63265459 |
Drug detoxification | 62.79 | 9.48 | 28 | 217841 | 304 | 63270849 |
Hallucination, visual | 62.28 | 9.48 | 176 | 217693 | 19122 | 63252031 |
Feeding disorder | 62.14 | 9.48 | 140 | 217729 | 13222 | 63257931 |
Infection | 60.63 | 9.48 | 499 | 217370 | 228674 | 63042479 |
Ejection fraction abnormal | 59.02 | 9.48 | 49 | 217820 | 1736 | 63269417 |
Hypersensitivity | 58.23 | 9.48 | 683 | 217186 | 292002 | 62979151 |
Analgesic drug level increased | 58.23 | 9.48 | 55 | 217814 | 2317 | 63268836 |
Lower respiratory tract infection | 57.99 | 9.48 | 245 | 217624 | 132062 | 63139091 |
Prescription drug used without a prescription | 57.95 | 9.48 | 55 | 217814 | 2331 | 63268822 |
Gastric pH decreased | 57.91 | 9.48 | 35 | 217834 | 739 | 63270414 |
Drug abuser | 57.36 | 9.48 | 60 | 217809 | 2863 | 63268290 |
Drug diversion | 56.21 | 9.48 | 37 | 217832 | 911 | 63270242 |
Seizure | 55.75 | 9.48 | 698 | 217171 | 131936 | 63139217 |
Respiratory acidosis | 55.67 | 9.48 | 90 | 217779 | 6625 | 63264528 |
Red blood cell sedimentation rate abnormal | 55.54 | 9.48 | 3 | 217866 | 19779 | 63251374 |
Irritable bowel syndrome | 54.19 | 9.48 | 127 | 217742 | 82285 | 63188868 |
Clonus | 54.14 | 9.48 | 73 | 217796 | 4563 | 63266590 |
Pyrexia | 53.33 | 9.48 | 1219 | 216650 | 469259 | 62801894 |
Nephrectomy | 53.23 | 9.48 | 43 | 217826 | 1465 | 63269688 |
Burning sensation | 52.99 | 9.48 | 344 | 217525 | 54063 | 63217090 |
Foot operation | 52.07 | 9.48 | 91 | 217778 | 7140 | 63264013 |
Mycotic allergy | 51.73 | 9.48 | 36 | 217833 | 974 | 63270179 |
Ear infection | 51.21 | 9.48 | 263 | 217606 | 37950 | 63233203 |
Dizziness | 50.43 | 9.48 | 1876 | 215993 | 428049 | 62843104 |
Depression | 50.13 | 9.48 | 950 | 216919 | 195542 | 63075611 |
Hyponatraemia | 48.79 | 9.48 | 593 | 217276 | 111307 | 63159846 |
Poisoning | 48.24 | 9.48 | 129 | 217740 | 13571 | 63257582 |
Confusional state | 47.95 | 9.48 | 1105 | 216764 | 235275 | 63035878 |
Victim of chemical submission | 47.56 | 9.48 | 27 | 217842 | 505 | 63270648 |
Sleep disorder due to general medical condition, insomnia type | 47.30 | 9.48 | 66 | 217803 | 52151 | 63219002 |
Sleep disorder due to a general medical condition | 47.27 | 9.48 | 119 | 217750 | 12069 | 63259084 |
Hypophagia | 46.04 | 9.48 | 221 | 217648 | 31038 | 63240115 |
Suicidal ideation | 45.95 | 9.48 | 369 | 217500 | 62052 | 63209101 |
Feeling of despair | 45.88 | 9.48 | 48 | 217821 | 2291 | 63268862 |
Loss of consciousness | 45.17 | 9.48 | 611 | 217258 | 117510 | 63153643 |
Hyperhidrosis | 45.09 | 9.48 | 567 | 217302 | 107269 | 63163884 |
Agitation | 44.39 | 9.48 | 354 | 217515 | 59403 | 63211750 |
Constipation | 44.23 | 9.48 | 1047 | 216822 | 223896 | 63047257 |
H1N1 influenza | 43.99 | 9.48 | 41 | 217828 | 1698 | 63269455 |
Abortion spontaneous | 43.40 | 9.48 | 59 | 217810 | 47136 | 63224017 |
Disorientation | 43.15 | 9.48 | 257 | 217612 | 39195 | 63231958 |
Decorticate posture | 42.90 | 9.48 | 21 | 217848 | 286 | 63270867 |
Hyperacusis | 42.59 | 9.48 | 44 | 217825 | 2069 | 63269084 |
Somatic symptom disorder | 42.48 | 9.48 | 49 | 217820 | 2611 | 63268542 |
Chronic kidney disease | 42.36 | 9.48 | 284 | 217585 | 45114 | 63226039 |
Pain | 42.21 | 9.48 | 2095 | 215774 | 738533 | 62532620 |
Myoclonus | 42.04 | 9.48 | 135 | 217734 | 15733 | 63255420 |
Multiple drug therapy | 41.95 | 9.48 | 57 | 217812 | 3589 | 63267564 |
Respiratory arrest | 41.89 | 9.48 | 222 | 217647 | 32423 | 63238730 |
Vertigo | 41.38 | 9.48 | 349 | 217520 | 59538 | 63211615 |
Urinary retention | 40.92 | 9.48 | 209 | 217660 | 30092 | 63241061 |
Myocardial depression | 40.86 | 9.48 | 24 | 217845 | 480 | 63270673 |
Blister | 40.85 | 9.48 | 269 | 217600 | 129545 | 63141608 |
Muscle rigidity | 40.20 | 9.48 | 108 | 217761 | 11392 | 63259761 |
Deafness | 39.87 | 9.48 | 144 | 217725 | 17813 | 63253340 |
Delirium | 39.53 | 9.48 | 303 | 217566 | 50238 | 63220915 |
Cyanosis | 39.48 | 9.48 | 138 | 217731 | 16797 | 63254356 |
Peripheral circulatory failure | 39.34 | 9.48 | 30 | 217839 | 938 | 63270215 |
Encephalopathy | 39.34 | 9.48 | 247 | 217622 | 38373 | 63232780 |
Dissociation | 38.81 | 9.48 | 49 | 217820 | 2870 | 63268283 |
Acute generalised exanthematous pustulosis | 38.57 | 9.48 | 104 | 217765 | 10995 | 63260158 |
Drug tolerance decreased | 37.93 | 9.48 | 7 | 217862 | 17466 | 63253687 |
Myelosuppression | 37.74 | 9.48 | 17 | 217852 | 23686 | 63247467 |
Headache | 37.36 | 9.48 | 2586 | 215283 | 630655 | 62640498 |
Intentional product use issue | 36.81 | 9.48 | 272 | 217597 | 127620 | 63143533 |
Speech disorder | 36.62 | 9.48 | 252 | 217617 | 40377 | 63230776 |
Musculoskeletal disorder | 36.44 | 9.48 | 154 | 217715 | 20490 | 63250663 |
Rheumatoid arthritis | 36.10 | 9.48 | 633 | 217236 | 253186 | 63017967 |
Hypoglycaemia | 35.83 | 9.48 | 339 | 217530 | 59726 | 63211427 |
Swollen joint count increased | 35.29 | 9.48 | 43 | 217826 | 36011 | 63235142 |
Fracture | 35.28 | 9.48 | 147 | 217722 | 19437 | 63251716 |
Rheumatoid nodule | 34.91 | 9.48 | 8 | 217861 | 17147 | 63254006 |
Cogwheel rigidity | 34.37 | 9.48 | 38 | 217831 | 1932 | 63269221 |
Renal disorder | 34.28 | 9.48 | 212 | 217657 | 32762 | 63238391 |
Cryopyrin associated periodic syndrome | 34.16 | 9.48 | 19 | 217850 | 341 | 63270812 |
Victim of sexual abuse | 34.14 | 9.48 | 24 | 217845 | 660 | 63270493 |
Eyelid myoclonus | 33.16 | 9.48 | 13 | 217856 | 99 | 63271054 |
Rheumatic fever | 32.92 | 9.48 | 61 | 217808 | 43050 | 63228103 |
Drug resistance | 32.70 | 9.48 | 19 | 217850 | 22914 | 63248239 |
Blood cholesterol increased | 32.62 | 9.48 | 189 | 217680 | 93843 | 63177310 |
Ankylosing spondylitis | 32.32 | 9.48 | 94 | 217775 | 10380 | 63260773 |
Pituitary tumour benign | 32.28 | 9.48 | 37 | 217832 | 1958 | 63269195 |
Coma scale abnormal | 32.22 | 9.48 | 61 | 217808 | 5092 | 63266061 |
Sphincter of Oddi dysfunction | 32.21 | 9.48 | 19 | 217850 | 383 | 63270770 |
Disturbance in attention | 32.16 | 9.48 | 233 | 217636 | 37956 | 63233197 |
Muscle spasms | 31.96 | 9.48 | 731 | 217138 | 155419 | 63115734 |
Skin necrosis | 31.58 | 9.48 | 5 | 217864 | 13945 | 63257208 |
Stomatitis | 31.45 | 9.48 | 314 | 217555 | 138411 | 63132742 |
Pancreatic fibrosis | 31.23 | 9.48 | 12 | 217857 | 86 | 63271067 |
Tonic clonic movements | 30.96 | 9.48 | 31 | 217838 | 1404 | 63269749 |
Nightmare | 30.69 | 9.48 | 139 | 217730 | 19055 | 63252098 |
Therapeutic product ineffective | 30.60 | 9.48 | 34 | 217835 | 1738 | 63269415 |
Pancreatitis acute | 30.37 | 9.48 | 178 | 217691 | 26988 | 63244165 |
Febrile neutropenia | 30.34 | 9.48 | 260 | 217609 | 118189 | 63152964 |
Leukopenia | 30.34 | 9.48 | 149 | 217720 | 77141 | 63194012 |
Psychotic disorder due to a general medical condition | 30.18 | 9.48 | 16 | 217853 | 260 | 63270893 |
Hallucinations, mixed | 29.99 | 9.48 | 57 | 217812 | 4772 | 63266381 |
Adverse reaction | 29.99 | 9.48 | 90 | 217779 | 10113 | 63261040 |
Visceral congestion | 29.71 | 9.48 | 17 | 217852 | 323 | 63270830 |
Acute motor-sensory axonal neuropathy | 29.49 | 9.48 | 16 | 217853 | 273 | 63270880 |
Feeling of body temperature change | 29.43 | 9.48 | 57 | 217812 | 4840 | 63266313 |
Limb injury | 29.17 | 9.48 | 168 | 217701 | 25309 | 63245844 |
Fibromyalgia | 29.11 | 9.48 | 412 | 217457 | 80008 | 63191145 |
Sacroiliitis | 28.86 | 9.48 | 45 | 217824 | 3212 | 63267941 |
Hypothermia | 28.54 | 9.48 | 107 | 217762 | 13474 | 63257679 |
Macular degeneration | 28.46 | 9.48 | 25 | 217844 | 24351 | 63246802 |
Restless legs syndrome | 28.01 | 9.48 | 132 | 217737 | 18399 | 63252754 |
Muscle disorder | 27.65 | 9.48 | 56 | 217813 | 4913 | 63266240 |
Nasopharyngitis | 27.55 | 9.48 | 663 | 217206 | 253594 | 63017559 |
Ill-defined disorder | 27.47 | 9.48 | 166 | 217703 | 81589 | 63189564 |
Tremor | 27.35 | 9.48 | 620 | 217249 | 131619 | 63139534 |
Anxiety | 27.32 | 9.48 | 957 | 216912 | 216584 | 63054569 |
Drug eruption | 27.27 | 9.48 | 35 | 217834 | 28659 | 63242494 |
Myocardial fibrosis | 27.22 | 9.48 | 22 | 217847 | 750 | 63270403 |
Creatinine renal clearance decreased | 27.07 | 9.48 | 11 | 217858 | 16297 | 63254856 |
Premature baby | 27.07 | 9.48 | 19 | 217850 | 20716 | 63250437 |
Depressed level of consciousness | 27.05 | 9.48 | 329 | 217540 | 61749 | 63209404 |
Gastrooesophageal reflux disease | 27.03 | 9.48 | 470 | 217399 | 95169 | 63175984 |
Cardiac disorder | 27 | 9.48 | 280 | 217589 | 50536 | 63220617 |
Cestode infection | 26.84 | 9.48 | 15 | 217854 | 272 | 63270881 |
Unresponsive to stimuli | 26.59 | 9.48 | 203 | 217666 | 33613 | 63237540 |
Cytomegalovirus infection | 26.32 | 9.48 | 20 | 217849 | 20932 | 63250221 |
C-reactive protein increased | 26.03 | 9.48 | 204 | 217665 | 94503 | 63176650 |
Brain injury | 25.49 | 9.48 | 67 | 217802 | 6976 | 63264177 |
Swollen tongue | 25.21 | 9.48 | 205 | 217664 | 34595 | 63236558 |
Blood creatinine increased | 25.19 | 9.48 | 187 | 217682 | 87657 | 63183496 |
Neck pain | 25.04 | 9.48 | 355 | 217514 | 68963 | 63202190 |
Feeling abnormal | 24.80 | 9.48 | 676 | 217193 | 147716 | 63123437 |
Drooling | 24.45 | 9.48 | 46 | 217823 | 3822 | 63267331 |
Caesarean section | 24.45 | 9.48 | 14 | 217855 | 17018 | 63254135 |
Substance abuse | 24.20 | 9.48 | 52 | 217817 | 4755 | 63266398 |
Death | 24.16 | 9.48 | 1541 | 216328 | 372840 | 62898313 |
Hyperreflexia | 24.13 | 9.48 | 59 | 217810 | 5875 | 63265278 |
Transplant rejection | 24.10 | 9.48 | 4 | 217865 | 10776 | 63260377 |
Eagle Barrett syndrome | 23.93 | 9.48 | 6 | 217863 | 6 | 63271147 |
Abdominal pain upper | 23.92 | 9.48 | 900 | 216969 | 205544 | 63065609 |
Restlessness | 23.83 | 9.48 | 178 | 217691 | 29275 | 63241878 |
Bone lesion | 23.42 | 9.48 | 58 | 217811 | 5823 | 63265330 |
Disease progression | 23.40 | 9.48 | 289 | 217580 | 122469 | 63148684 |
Accidental overdose | 23.07 | 9.48 | 148 | 217721 | 23161 | 63247992 |
General physical health deterioration | 22.97 | 9.48 | 521 | 217348 | 200881 | 63070272 |
Neutropenia | 22.81 | 9.48 | 443 | 217426 | 174562 | 63096591 |
Hepatic function abnormal | 22.26 | 9.48 | 60 | 217809 | 37082 | 63234071 |
Listless | 21.92 | 9.48 | 37 | 217832 | 2823 | 63268330 |
Tinnitus | 21.70 | 9.48 | 202 | 217667 | 35426 | 63235727 |
Blood calcium decreased | 21.48 | 9.48 | 36 | 217833 | 26415 | 63244738 |
Congenital central hypoventilation syndrome | 21.38 | 9.48 | 7 | 217862 | 29 | 63271124 |
Pulmonary fibrosis | 21.18 | 9.48 | 68 | 217801 | 39741 | 63231412 |
Disease recurrence | 21.10 | 9.48 | 40 | 217829 | 27990 | 63243163 |
Hip arthroplasty | 21 | 9.48 | 88 | 217781 | 47558 | 63223595 |
Pregnancy | 20.97 | 9.48 | 61 | 217808 | 36775 | 63234378 |
Hypertonia neonatal | 20.79 | 9.48 | 12 | 217857 | 232 | 63270921 |
Product use in unapproved indication | 20.78 | 9.48 | 462 | 217407 | 178618 | 63092535 |
Menstrual disorder | 20.73 | 9.48 | 52 | 217817 | 5261 | 63265892 |
Perineal fistula | 20.66 | 9.48 | 7 | 217862 | 33 | 63271120 |
Deep vein thrombosis | 20.60 | 9.48 | 403 | 217466 | 83397 | 63187756 |
Muscle tone disorder | 20.57 | 9.48 | 10 | 217859 | 134 | 63271019 |
Epilepsy | 20.46 | 9.48 | 161 | 217708 | 26904 | 63244249 |
Inappropriate antidiuretic hormone secretion | 20.42 | 9.48 | 106 | 217763 | 15356 | 63255797 |
Hyperlipasaemia | 20.37 | 9.48 | 18 | 217851 | 695 | 63270458 |
Sedation complication | 20.36 | 9.48 | 11 | 217858 | 13811 | 63257342 |
Liver injury | 20.27 | 9.48 | 123 | 217746 | 60397 | 63210756 |
Obstructive airways disorder | 19.93 | 9.48 | 25 | 217844 | 20674 | 63250479 |
Accidental exposure to product | 19.86 | 9.48 | 40 | 217829 | 27365 | 63243788 |
Heart rate decreased | 19.56 | 9.48 | 85 | 217784 | 45475 | 63225678 |
Snoring | 19.51 | 9.48 | 44 | 217825 | 4158 | 63266995 |
Parosmia | 19.44 | 9.48 | 56 | 217813 | 6150 | 63265003 |
Blood parathyroid hormone decreased | 19.08 | 9.48 | 5 | 217864 | 9786 | 63261367 |
Hypothyroidism | 19.04 | 9.48 | 227 | 217642 | 42405 | 63228748 |
Persistent genital arousal disorder | 19.03 | 9.48 | 12 | 217857 | 274 | 63270879 |
Pneumocystis jirovecii pneumonia | 18.97 | 9.48 | 18 | 217851 | 16896 | 63254257 |
Gallbladder polyp | 18.85 | 9.48 | 18 | 217851 | 769 | 63270384 |
Congenital hypoplasia of depressor angularis oris muscle | 18.71 | 9.48 | 4 | 217865 | 0 | 63271153 |
Wrong technique in product usage process | 18.70 | 9.48 | 131 | 217738 | 62209 | 63208944 |
Arthralgia | 18.56 | 9.48 | 1693 | 216176 | 568017 | 62703136 |
Nephropathy toxic | 18.17 | 9.48 | 5 | 217864 | 9474 | 63261679 |
Road traffic accident | 18.13 | 9.48 | 199 | 217670 | 36433 | 63234720 |
Premature delivery | 18.09 | 9.48 | 49 | 217820 | 30232 | 63240921 |
Livedo reticularis | 18.03 | 9.48 | 31 | 217838 | 2401 | 63268752 |
Bladder prolapse | 18.01 | 9.48 | 29 | 217840 | 2127 | 63269026 |
Respiratory disorder | 17.97 | 9.48 | 71 | 217798 | 39011 | 63232142 |
Hypersensitivity vasculitis | 17.92 | 9.48 | 42 | 217827 | 4070 | 63267083 |
Intervertebral disc protrusion | 17.90 | 9.48 | 141 | 217728 | 23568 | 63247585 |
Hepatotoxicity | 17.86 | 9.48 | 66 | 217803 | 36975 | 63234178 |
Weight increased | 17.76 | 9.48 | 723 | 217146 | 260069 | 63011084 |
Interstitial lung disease | 17.64 | 9.48 | 132 | 217737 | 61776 | 63209377 |
Paralysis | 17.59 | 9.48 | 74 | 217795 | 9826 | 63261327 |
Enthesopathy | 17.56 | 9.48 | 4 | 217865 | 8610 | 63262543 |
Metastases to liver | 17.56 | 9.48 | 34 | 217835 | 23605 | 63247548 |
Thermal burn | 17.46 | 9.48 | 53 | 217816 | 5993 | 63265160 |
Cholangiocarcinoma | 17.42 | 9.48 | 21 | 217848 | 1173 | 63269980 |
Inadequate analgesia | 17.37 | 9.48 | 34 | 217835 | 2909 | 63268244 |
Neuralgia | 17.33 | 9.48 | 150 | 217719 | 25776 | 63245377 |
Allergy test negative | 17.29 | 9.48 | 10 | 217859 | 194 | 63270959 |
Cardiogenic shock | 17.22 | 9.48 | 113 | 217756 | 17819 | 63253334 |
Decreased appetite | 17.22 | 9.48 | 1039 | 216830 | 250013 | 63021140 |
Eating disorder | 17.16 | 9.48 | 118 | 217751 | 18898 | 63252255 |
Breast disorder | 17.14 | 9.48 | 31 | 217838 | 2499 | 63268654 |
Fear of disease | 17.12 | 9.48 | 22 | 217847 | 1312 | 63269841 |
Faecaloma | 17.05 | 9.48 | 63 | 217806 | 7878 | 63263275 |
Bone marrow failure | 17.04 | 9.48 | 48 | 217821 | 29242 | 63241911 |
Performance enhancing product use | 17.03 | 9.48 | 5 | 217864 | 13 | 63271140 |
Type 2 diabetes mellitus | 16.89 | 9.48 | 139 | 217730 | 63729 | 63207424 |
Ventricular hypokinesia | 16.62 | 9.48 | 44 | 217825 | 4600 | 63266553 |
Haematoma muscle | 16.59 | 9.48 | 20 | 217849 | 1117 | 63270036 |
Behaviour disorder | 16.56 | 9.48 | 35 | 217834 | 3164 | 63267989 |
Oral discomfort | 16.52 | 9.48 | 69 | 217800 | 9132 | 63262021 |
Diabetes mellitus inadequate control | 16.19 | 9.48 | 98 | 217771 | 15028 | 63256125 |
Lip pruritus | 16.06 | 9.48 | 18 | 217851 | 929 | 63270224 |
Thymus disorder | 16.05 | 9.48 | 11 | 217858 | 290 | 63270863 |
Anoxia | 15.95 | 9.48 | 10 | 217859 | 226 | 63270927 |
Secondary adrenocortical insufficiency | 15.94 | 9.48 | 22 | 217847 | 1406 | 63269747 |
Mood swings | 15.74 | 9.48 | 112 | 217757 | 18136 | 63253017 |
Multiple organ dysfunction syndrome | 15.70 | 9.48 | 122 | 217747 | 56630 | 63214523 |
Rectal prolapse | 15.66 | 9.48 | 26 | 217843 | 1957 | 63269196 |
Umbilical hernia | 15.63 | 9.48 | 33 | 217836 | 2981 | 63268172 |
Feeling drunk | 15.60 | 9.48 | 40 | 217829 | 4102 | 63267051 |
Vaccination site reaction | 15.60 | 9.48 | 8 | 217861 | 121 | 63271032 |
Back injury | 15.48 | 9.48 | 70 | 217799 | 9590 | 63261563 |
Labelled drug-drug interaction issue | 15.47 | 9.48 | 19 | 217850 | 1082 | 63270071 |
Panniculitis | 15.44 | 9.48 | 10 | 217859 | 11375 | 63259778 |
Fear of injection | 15.28 | 9.48 | 3 | 217866 | 7161 | 63263992 |
Device ineffective | 15.27 | 9.48 | 10 | 217859 | 244 | 63270909 |
Hypoacusis | 15.25 | 9.48 | 138 | 217731 | 24013 | 63247140 |
Gastritis | 15.10 | 9.48 | 195 | 217674 | 37108 | 63234045 |
Apnoea | 15.07 | 9.48 | 61 | 217808 | 7961 | 63263192 |
Magnesium deficiency | 15.06 | 9.48 | 14 | 217855 | 578 | 63270575 |
Septic shock | 15.01 | 9.48 | 151 | 217718 | 66478 | 63204675 |
Hypoaesthesia oral | 14.96 | 9.48 | 86 | 217783 | 12947 | 63258206 |
Deformity | 14.87 | 9.48 | 11 | 217858 | 11673 | 63259480 |
Thrombocytopenia | 14.79 | 9.48 | 400 | 217469 | 150757 | 63120396 |
Therapy non-responder | 14.72 | 9.48 | 178 | 217691 | 75723 | 63195430 |
Diastolic hypotension | 14.65 | 9.48 | 7 | 217862 | 90 | 63271063 |
Maternal exposure before pregnancy | 14.59 | 9.48 | 4 | 217865 | 7599 | 63263554 |
Foaming at mouth | 14.58 | 9.48 | 19 | 217850 | 1149 | 63270004 |
Premenstrual syndrome | 14.54 | 9.48 | 15 | 217854 | 704 | 63270449 |
COVID-19 | 14.52 | 9.48 | 287 | 217582 | 112816 | 63158337 |
Platelet count decreased | 14.51 | 9.48 | 296 | 217573 | 115826 | 63155327 |
Haemoglobin decreased | 14.49 | 9.48 | 384 | 217485 | 145101 | 63126052 |
Erythema | 14.49 | 9.48 | 476 | 217393 | 175275 | 63095878 |
Condition aggravated | 14.45 | 9.48 | 1186 | 216683 | 401031 | 62870122 |
Accidental death | 14.40 | 9.48 | 25 | 217844 | 1951 | 63269202 |
Vasoplegia syndrome | 14.40 | 9.48 | 23 | 217846 | 1676 | 63269477 |
Foetal malnutrition | 14.39 | 9.48 | 7 | 217862 | 94 | 63271059 |
Congenital diaphragmatic eventration | 14.35 | 9.48 | 4 | 217865 | 8 | 63271145 |
Cholangiectasis acquired | 14.35 | 9.48 | 4 | 217865 | 8 | 63271145 |
Wrong rate | 14.34 | 9.48 | 6 | 217863 | 55 | 63271098 |
Purple glove syndrome | 14.33 | 9.48 | 9 | 217860 | 204 | 63270949 |
Breast cancer stage II | 14.33 | 9.48 | 6 | 217863 | 8730 | 63262423 |
Chemical submission | 14.32 | 9.48 | 10 | 217859 | 272 | 63270881 |
Prothrombin time shortened | 14.23 | 9.48 | 25 | 217844 | 1970 | 63269183 |
Growth disorder | 14.20 | 9.48 | 5 | 217864 | 27 | 63271126 |
Sinusitis | 14.04 | 9.48 | 635 | 217234 | 226018 | 63045135 |
Cleft uvula | 14.03 | 9.48 | 4 | 217865 | 9 | 63271144 |
Antibiotic therapy | 13.98 | 9.48 | 18 | 217851 | 1075 | 63270078 |
Polymenorrhoea | 13.91 | 9.48 | 19 | 217850 | 1202 | 63269951 |
Amnesia | 13.89 | 9.48 | 268 | 217601 | 55317 | 63215836 |
Abdominal wound dehiscence | 13.88 | 9.48 | 9 | 217860 | 216 | 63270937 |
Adjustment disorder with depressed mood | 13.79 | 9.48 | 9 | 217860 | 10195 | 63260958 |
Lichen sclerosus | 13.78 | 9.48 | 18 | 217851 | 1091 | 63270062 |
Victim of child abuse | 13.74 | 9.48 | 4 | 217865 | 10 | 63271143 |
Pneumonia viral | 13.72 | 9.48 | 5 | 217864 | 7917 | 63263236 |
Hypertonia | 13.72 | 9.48 | 41 | 217828 | 4596 | 63266557 |
Vasculitis | 13.69 | 9.48 | 26 | 217843 | 18183 | 63252970 |
Alkalosis hypochloraemic | 13.66 | 9.48 | 8 | 217861 | 159 | 63270994 |
Renal impairment | 13.63 | 9.48 | 217 | 217652 | 88138 | 63183015 |
Blood pressure increased | 13.58 | 9.48 | 438 | 217431 | 161624 | 63109529 |
Narcolepsy | 13.57 | 9.48 | 20 | 217849 | 1358 | 63269795 |
Insomnia | 13.49 | 9.48 | 884 | 216985 | 214368 | 63056785 |
Electrocardiogram QT interval | 13.49 | 9.48 | 8 | 217861 | 163 | 63270990 |
Vertebrobasilar insufficiency | 13.49 | 9.48 | 8 | 217861 | 163 | 63270990 |
Altered state of consciousness | 13.39 | 9.48 | 139 | 217730 | 25091 | 63246062 |
Haemodialysis | 13.36 | 9.48 | 7 | 217862 | 8940 | 63262213 |
Hepatitis | 13.28 | 9.48 | 201 | 217668 | 39587 | 63231566 |
Emotional disorder | 13.27 | 9.48 | 85 | 217784 | 13294 | 63257859 |
Pulmonary toxicity | 13.25 | 9.48 | 8 | 217861 | 9447 | 63261706 |
Product label confusion | 13.21 | 9.48 | 23 | 217846 | 1799 | 63269354 |
Mixed liver injury | 13.20 | 9.48 | 41 | 217828 | 4694 | 63266459 |
Frequent bowel movements | 13.19 | 9.48 | 38 | 217831 | 22984 | 63248169 |
Incorrect route of product administration | 13.18 | 9.48 | 49 | 217820 | 27403 | 63243750 |
Gallbladder cholesterolosis | 13.13 | 9.48 | 15 | 217854 | 791 | 63270362 |
Injection site reaction | 13.03 | 9.48 | 133 | 217736 | 58391 | 63212762 |
Eosinophil count increased | 13.01 | 9.48 | 11 | 217858 | 10917 | 63260236 |
Surgery | 13.00 | 9.48 | 184 | 217685 | 35728 | 63235425 |
Pathogen resistance | 12.99 | 9.48 | 3 | 217866 | 6395 | 63264758 |
Gait inability | 12.78 | 9.48 | 254 | 217615 | 52705 | 63218448 |
Complication of device insertion | 12.72 | 9.48 | 5 | 217864 | 7559 | 63263594 |
Spinal operation | 12.56 | 9.48 | 59 | 217810 | 8212 | 63262941 |
Initial insomnia | 12.52 | 9.48 | 48 | 217821 | 6109 | 63265044 |
Tuberculosis | 12.49 | 9.48 | 12 | 217857 | 11199 | 63259954 |
Prothrombin level increased | 12.48 | 9.48 | 9 | 217860 | 258 | 63270895 |
Lymphomatoid papulosis | 12.47 | 9.48 | 7 | 217862 | 128 | 63271025 |
Bradycardia foetal | 12.44 | 9.48 | 11 | 217858 | 425 | 63270728 |
Hypercapnic coma | 12.37 | 9.48 | 8 | 217861 | 191 | 63270962 |
Psychomotor skills impaired | 12.37 | 9.48 | 26 | 217843 | 2342 | 63268811 |
Hypertension | 12.35 | 9.48 | 1116 | 216753 | 278187 | 62992966 |
Vascular encephalopathy | 12.33 | 9.48 | 11 | 217858 | 430 | 63270723 |
Ulcer | 12.27 | 9.48 | 47 | 217822 | 26060 | 63245093 |
Bradyphrenia | 12.26 | 9.48 | 52 | 217817 | 6928 | 63264225 |
Tachycardia | 12.24 | 9.48 | 509 | 217360 | 117647 | 63153506 |
Central nervous system stimulation | 12.23 | 9.48 | 5 | 217864 | 43 | 63271110 |
Dementia | 12.18 | 9.48 | 108 | 217761 | 18686 | 63252467 |
Nodular rash | 12.15 | 9.48 | 8 | 217861 | 197 | 63270956 |
Stillbirth | 12.14 | 9.48 | 4 | 217865 | 6746 | 63264407 |
Withdrawal catatonia | 12.11 | 9.48 | 6 | 217863 | 84 | 63271069 |
Substance use disorder | 12.08 | 9.48 | 8 | 217861 | 199 | 63270954 |
Rhabdomyolysis | 12.06 | 9.48 | 215 | 217654 | 43736 | 63227417 |
Therapeutic response decreased | 12.04 | 9.48 | 144 | 217725 | 61381 | 63209772 |
Carotid pulse abnormal | 11.97 | 9.48 | 3 | 217866 | 3 | 63271150 |
Candida endophthalmitis | 11.94 | 9.48 | 5 | 217864 | 46 | 63271107 |
Tenosynovitis | 11.94 | 9.48 | 18 | 217851 | 13777 | 63257376 |
Pre-existing condition improved | 11.93 | 9.48 | 58 | 217811 | 8186 | 63262967 |
Fatigue | 11.88 | 9.48 | 2784 | 215085 | 885244 | 62385909 |
Mood altered | 11.87 | 9.48 | 89 | 217780 | 14654 | 63256499 |
Retinal toxicity | 11.84 | 9.48 | 18 | 217851 | 1257 | 63269896 |
Dermo-hypodermitis | 11.81 | 9.48 | 9 | 217860 | 281 | 63270872 |
Carbohydrate antigen 15-3 | 11.80 | 9.48 | 6 | 217863 | 89 | 63271064 |
Oral lichenoid reaction | 11.80 | 9.48 | 6 | 217863 | 89 | 63271064 |
Normal newborn | 11.77 | 9.48 | 7 | 217862 | 8334 | 63262819 |
Electric shock sensation | 11.72 | 9.48 | 14 | 217855 | 774 | 63270379 |
Increased tendency to bruise | 11.70 | 9.48 | 69 | 217800 | 10483 | 63260670 |
Neuromyopathy | 11.68 | 9.48 | 13 | 217856 | 666 | 63270487 |
Carcinoembryonic antigen | 11.63 | 9.48 | 6 | 217863 | 92 | 63271061 |
Urinary tract infection | 11.61 | 9.48 | 1057 | 216812 | 263627 | 63007526 |
Neuroglycopenia | 11.57 | 9.48 | 11 | 217858 | 467 | 63270686 |
Transcription medication error | 11.57 | 9.48 | 8 | 217861 | 214 | 63270939 |
Basal cell carcinoma | 11.54 | 9.48 | 53 | 217816 | 27938 | 63243215 |
Foreign body | 11.44 | 9.48 | 25 | 217844 | 2313 | 63268840 |
Vitamin D decreased | 11.38 | 9.48 | 67 | 217802 | 10175 | 63260978 |
Hypoventilation | 11.31 | 9.48 | 39 | 217830 | 4715 | 63266438 |
Fat tissue decreased | 11.30 | 9.48 | 4 | 217865 | 22 | 63271131 |
Bruxism | 11.23 | 9.48 | 32 | 217837 | 3493 | 63267660 |
Dysphoria | 11.17 | 9.48 | 40 | 217829 | 4926 | 63266227 |
Back pain | 11.16 | 9.48 | 1052 | 216817 | 263093 | 63008060 |
Moebius II syndrome | 11.15 | 9.48 | 4 | 217865 | 23 | 63271130 |
Abdominal pain lower | 11.15 | 9.48 | 136 | 217733 | 25542 | 63245611 |
Hypotonia | 11.14 | 9.48 | 62 | 217807 | 9223 | 63261930 |
Post cardiac arrest syndrome | 11.01 | 9.48 | 4 | 217865 | 24 | 63271129 |
Intestinal diaphragm disease | 10.97 | 9.48 | 6 | 217863 | 104 | 63271049 |
Dry mouth | 10.90 | 9.48 | 347 | 217522 | 77516 | 63193637 |
Multiple injuries | 10.89 | 9.48 | 21 | 217848 | 1777 | 63269376 |
Live birth | 10.89 | 9.48 | 48 | 217821 | 25582 | 63245571 |
Drug dependence, antepartum | 10.87 | 9.48 | 4 | 217865 | 25 | 63271128 |
Myelodysplastic syndrome | 10.86 | 9.48 | 26 | 217843 | 16728 | 63254425 |
Foetal death | 10.85 | 9.48 | 13 | 217856 | 10967 | 63260186 |
Porphyria | 10.83 | 9.48 | 7 | 217862 | 167 | 63270986 |
Lung neoplasm malignant | 10.82 | 9.48 | 33 | 217836 | 19600 | 63251553 |
Depressed mood | 10.81 | 9.48 | 196 | 217673 | 39995 | 63231158 |
Cytomegalovirus viraemia | 10.79 | 9.48 | 3 | 217866 | 5646 | 63265507 |
Bladder dilatation | 10.79 | 9.48 | 14 | 217855 | 843 | 63270310 |
Haemodynamic instability | 10.78 | 9.48 | 61 | 217808 | 9129 | 63262024 |
Body temperature increased | 10.74 | 9.48 | 79 | 217790 | 37113 | 63234040 |
Asthma | 10.72 | 9.48 | 538 | 217331 | 127023 | 63144130 |
Gait disturbance | 10.72 | 9.48 | 748 | 217121 | 182430 | 63088723 |
Acquired cystic kidney disease | 10.70 | 9.48 | 5 | 217864 | 61 | 63271092 |
Lymphopenia | 10.69 | 9.48 | 30 | 217839 | 18297 | 63252856 |
Musculoskeletal stiffness | 10.68 | 9.48 | 521 | 217348 | 184097 | 63087056 |
Substance use | 10.67 | 9.48 | 11 | 217858 | 516 | 63270637 |
Neutrophil count decreased | 10.66 | 9.48 | 133 | 217736 | 56273 | 63214880 |
Neonatal hypoxia | 10.65 | 9.48 | 12 | 217857 | 623 | 63270530 |
Nystagmus | 10.65 | 9.48 | 4 | 217865 | 6216 | 63264937 |
Retinitis | 10.58 | 9.48 | 4 | 217865 | 6192 | 63264961 |
Life support | 10.58 | 9.48 | 8 | 217861 | 247 | 63270906 |
Haemolysis | 10.55 | 9.48 | 5 | 217864 | 6763 | 63264390 |
No adverse event | 10.55 | 9.48 | 91 | 217778 | 41314 | 63229839 |
Cystitis noninfective | 10.52 | 9.48 | 15 | 217854 | 988 | 63270165 |
Breast cancer female | 10.51 | 9.48 | 19 | 217850 | 13540 | 63257613 |
Somnolence neonatal | 10.49 | 9.48 | 6 | 217863 | 114 | 63271039 |
Peptic ulcer | 10.36 | 9.48 | 37 | 217832 | 4550 | 63266603 |
Tuberculin test positive | 10.35 | 9.48 | 31 | 217838 | 3480 | 63267673 |
Haematemesis | 10.29 | 9.48 | 154 | 217715 | 30258 | 63240895 |
Hypokalaemia | 10.26 | 9.48 | 445 | 217424 | 103359 | 63167794 |
Appetite disorder | 10.24 | 9.48 | 51 | 217818 | 7270 | 63263883 |
Gastrointestinal toxicity | 10.23 | 9.48 | 7 | 217862 | 7734 | 63263419 |
Peritoneal perforation | 10.21 | 9.48 | 6 | 217863 | 120 | 63271033 |
Benzodiazepine drug level increased | 10.20 | 9.48 | 7 | 217862 | 185 | 63270968 |
Thinking abnormal | 10.18 | 9.48 | 67 | 217802 | 10576 | 63260577 |
Abdominal tenderness | 10.11 | 9.48 | 55 | 217814 | 8111 | 63263042 |
Rectal spasm | 10.09 | 9.48 | 5 | 217864 | 70 | 63271083 |
Haemophagocytic lymphohistiocytosis | 10.06 | 9.48 | 13 | 217856 | 10614 | 63260539 |
Hepatic enzyme abnormal | 10.00 | 9.48 | 46 | 217823 | 6346 | 63264807 |
Hot flush | 9.99 | 9.48 | 238 | 217631 | 50921 | 63220232 |
Hypercapnia | 9.96 | 9.48 | 41 | 217828 | 5390 | 63265763 |
Knee operation | 9.95 | 9.48 | 44 | 217825 | 5969 | 63265184 |
Poverty | 9.91 | 9.48 | 3 | 217866 | 9 | 63271144 |
Drug withdrawal syndrome neonatal | 9.90 | 9.48 | 22 | 217847 | 2059 | 63269094 |
Tearfulness | 9.88 | 9.48 | 34 | 217835 | 4105 | 63267048 |
Euphoric mood | 9.86 | 9.48 | 38 | 217831 | 4849 | 63266304 |
Congenital multiplex arthrogryposis | 9.82 | 9.48 | 4 | 217865 | 34 | 63271119 |
Back disorder | 9.73 | 9.48 | 68 | 217801 | 10949 | 63260204 |
Potentiating drug interaction | 9.73 | 9.48 | 35 | 217834 | 4321 | 63266832 |
Epstein-Barr virus infection | 9.71 | 9.48 | 8 | 217861 | 8042 | 63263111 |
Enostosis | 9.67 | 9.48 | 3 | 217866 | 10 | 63271143 |
VIIIth nerve injury | 9.67 | 9.48 | 3 | 217866 | 10 | 63271143 |
Blood pressure systolic increased | 9.63 | 9.48 | 110 | 217759 | 47287 | 63223866 |
Respiratory depth decreased | 9.63 | 9.48 | 4 | 217865 | 36 | 63271117 |
Pneumonia | 9.57 | 9.48 | 1398 | 216471 | 455369 | 62815784 |
Injection site erythema | 9.52 | 9.48 | 215 | 217654 | 82959 | 63188194 |
Trigger finger | 9.49 | 9.48 | 35 | 217834 | 4373 | 63266780 |
Facial paresis | 9.48 | 9.48 | 30 | 217839 | 3468 | 63267685 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug dependence | 982.86 | 10.44 | 704 | 101968 | 23513 | 34830746 |
Drug abuse | 953.71 | 10.44 | 1308 | 101364 | 97788 | 34756471 |
Toxicity to various agents | 503.65 | 10.44 | 1508 | 101164 | 198854 | 34655405 |
Poisoning deliberate | 442.69 | 10.44 | 280 | 102392 | 7564 | 34846695 |
Overdose | 418.35 | 10.44 | 864 | 101808 | 90195 | 34764064 |
Prescription form tampering | 418.27 | 10.44 | 120 | 102552 | 346 | 34853913 |
Serotonin syndrome | 354.68 | 10.44 | 361 | 102311 | 19572 | 34834687 |
Intentional overdose | 329.85 | 10.44 | 515 | 102157 | 43159 | 34811100 |
Intentional product misuse | 321.31 | 10.44 | 521 | 102151 | 45090 | 34809169 |
Drug use disorder | 318 | 10.44 | 181 | 102491 | 4010 | 34850249 |
Coma | 313.96 | 10.44 | 516 | 102156 | 45162 | 34809097 |
Withdrawal syndrome | 257.71 | 10.44 | 245 | 102427 | 12210 | 34842049 |
Miosis | 231.24 | 10.44 | 205 | 102467 | 9330 | 34844929 |
Bradypnoea | 167.17 | 10.44 | 104 | 102568 | 2725 | 34851534 |
Respiratory depression | 137.33 | 10.44 | 202 | 102470 | 16043 | 34838216 |
Somnolence | 128.89 | 10.44 | 656 | 102016 | 110460 | 34743799 |
Seizure | 127.94 | 10.44 | 628 | 102044 | 104229 | 34750030 |
Asphyxia | 112.90 | 10.44 | 119 | 102553 | 6716 | 34847543 |
Confusional state | 112.70 | 10.44 | 767 | 101905 | 143393 | 34710866 |
Suicide attempt | 111.79 | 10.44 | 309 | 102363 | 38807 | 34815452 |
Drug abuser | 110.05 | 10.44 | 92 | 102580 | 3862 | 34850397 |
Off label use | 108.98 | 10.44 | 754 | 101918 | 418770 | 34435489 |
Drug dispensed to wrong patient | 108.45 | 10.44 | 45 | 102627 | 479 | 34853780 |
Generalised tonic-clonic seizure | 100.63 | 10.44 | 204 | 102468 | 20970 | 34833289 |
Prescription drug used without a prescription | 95.11 | 10.44 | 66 | 102606 | 2088 | 34852171 |
Poisoning | 94.75 | 10.44 | 146 | 102526 | 12080 | 34842179 |
Completed suicide | 87.47 | 10.44 | 540 | 102132 | 97628 | 34756631 |
Wrong patient received product | 82.80 | 10.44 | 66 | 102606 | 2588 | 34851671 |
Drug withdrawal syndrome | 81.39 | 10.44 | 180 | 102492 | 19654 | 34834605 |
Mydriasis | 76.14 | 10.44 | 100 | 102572 | 7137 | 34847122 |
Antimicrobial susceptibility test resistant | 67.03 | 10.44 | 29 | 102643 | 345 | 34853914 |
Minimum inhibitory concentration | 64.06 | 10.44 | 23 | 102649 | 159 | 34854100 |
Hypoglycaemia | 62.14 | 10.44 | 321 | 102351 | 54319 | 34799940 |
Depressed level of consciousness | 59.05 | 10.44 | 266 | 102406 | 42575 | 34811684 |
Loss of consciousness | 58.16 | 10.44 | 429 | 102243 | 82238 | 34772021 |
Hepatocellular injury | 58.11 | 10.44 | 170 | 102502 | 22041 | 34832218 |
Housebound | 58.05 | 10.44 | 23 | 102649 | 215 | 34854044 |
Inadequate analgesia | 56.78 | 10.44 | 56 | 102616 | 2919 | 34851340 |
Dependence | 54.95 | 10.44 | 37 | 102635 | 1113 | 34853146 |
Drug resistance | 54.93 | 10.44 | 6 | 102666 | 25921 | 34828338 |
Disorientation | 50.26 | 10.44 | 212 | 102460 | 32976 | 34821283 |
Disease progression | 50.03 | 10.44 | 157 | 102515 | 107920 | 34746339 |
Therapeutic response delayed | 49.60 | 10.44 | 28 | 102644 | 610 | 34853649 |
Analgesic drug level above therapeutic | 48.78 | 10.44 | 22 | 102650 | 291 | 34853968 |
Antidepressant drug level above therapeutic | 47.14 | 10.44 | 20 | 102652 | 226 | 34854033 |
Cholestasis | 45.46 | 10.44 | 178 | 102494 | 26770 | 34827489 |
Myoclonus | 44.72 | 10.44 | 119 | 102553 | 14606 | 34839653 |
Febrile neutropenia | 42.03 | 10.44 | 233 | 102439 | 136616 | 34717643 |
Constipation | 41.12 | 10.44 | 597 | 102075 | 136385 | 34717874 |
Pyrexia | 39.09 | 10.44 | 716 | 101956 | 332297 | 34521962 |
Accidental overdose | 38.94 | 10.44 | 139 | 102533 | 20001 | 34834258 |
Epilepsy | 37.90 | 10.44 | 144 | 102528 | 21351 | 34832908 |
Drug ineffective | 36.95 | 10.44 | 1041 | 101631 | 455710 | 34398549 |
Drug hypersensitivity | 36.79 | 10.44 | 380 | 102292 | 80149 | 34774110 |
Hallucination | 36.05 | 10.44 | 267 | 102405 | 51231 | 34803028 |
Agitation | 35.96 | 10.44 | 290 | 102382 | 57109 | 34797150 |
Drug tolerance | 35.36 | 10.44 | 43 | 102629 | 2839 | 34851420 |
Drug interaction | 35.10 | 10.44 | 890 | 101782 | 225056 | 34629203 |
Product use in unapproved indication | 35.02 | 10.44 | 202 | 102470 | 117297 | 34736962 |
Analgesic drug level increased | 34.94 | 10.44 | 25 | 102647 | 831 | 34853428 |
Expired product administered | 34.89 | 10.44 | 46 | 102626 | 3295 | 34850964 |
Cough | 34.85 | 10.44 | 278 | 102394 | 149862 | 34704397 |
White blood cell count decreased | 34.76 | 10.44 | 153 | 102519 | 95292 | 34758967 |
Joint dislocation | 34.65 | 10.44 | 48 | 102624 | 3605 | 34850654 |
Myocardial fibrosis | 33.62 | 10.44 | 28 | 102644 | 1169 | 34853090 |
Altered state of consciousness | 32.93 | 10.44 | 144 | 102528 | 22749 | 34831510 |
Anterograde amnesia | 32.63 | 10.44 | 14 | 102658 | 163 | 34854096 |
Apnoea | 32.60 | 10.44 | 65 | 102607 | 6599 | 34847660 |
Adrenergic syndrome | 32.58 | 10.44 | 12 | 102660 | 90 | 34854169 |
Narcotic bowel syndrome | 32.04 | 10.44 | 13 | 102659 | 130 | 34854129 |
Alanine aminotransferase increased | 31.63 | 10.44 | 126 | 102546 | 80689 | 34773570 |
Hyperhidrosis | 30.78 | 10.44 | 349 | 102323 | 75343 | 34778916 |
Platelet count decreased | 29.97 | 10.44 | 217 | 102455 | 119500 | 34734759 |
Parasomnia | 29.44 | 10.44 | 17 | 102655 | 387 | 34853872 |
Treatment failure | 29.27 | 10.44 | 58 | 102614 | 46639 | 34807620 |
Haemoglobin decreased | 28.77 | 10.44 | 222 | 102450 | 120550 | 34733709 |
Oedematous pancreatitis | 28.68 | 10.44 | 18 | 102654 | 479 | 34853780 |
Pneumonia aspiration | 28.62 | 10.44 | 216 | 102456 | 41687 | 34812572 |
Vomiting | 28.16 | 10.44 | 938 | 101734 | 246683 | 34607576 |
Hyperacusis | 27.70 | 10.44 | 22 | 102650 | 858 | 34853401 |
Hallucination, visual | 27.20 | 10.44 | 114 | 102558 | 17677 | 34836582 |
Anal haemorrhage | 26.16 | 10.44 | 35 | 102637 | 2543 | 34851716 |
Negative pressure pulmonary oedema | 25.96 | 10.44 | 13 | 102659 | 220 | 34854039 |
Symmetrical drug-related intertriginous and flexural exanthema | 25.96 | 10.44 | 15 | 102657 | 342 | 34853917 |
Mucosal inflammation | 25.94 | 10.44 | 46 | 102626 | 38576 | 34815683 |
Drug diversion | 25.60 | 10.44 | 21 | 102651 | 858 | 34853401 |
Respiratory acidosis | 25.60 | 10.44 | 50 | 102622 | 5000 | 34849259 |
Arteriovenous fistula | 25.18 | 10.44 | 23 | 102649 | 1088 | 34853171 |
Mixed anxiety and depressive disorder | 24.74 | 10.44 | 10 | 102662 | 99 | 34854160 |
Foetal disorder | 24.62 | 10.44 | 20 | 102652 | 806 | 34853453 |
Myelosuppression | 24.47 | 10.44 | 13 | 102659 | 19252 | 34835007 |
Urinary retention | 24.18 | 10.44 | 186 | 102486 | 36102 | 34818157 |
Behaviour disorder | 24.15 | 10.44 | 48 | 102624 | 4862 | 34849397 |
Tonic convulsion | 23.65 | 10.44 | 23 | 102649 | 1178 | 34853081 |
Euphoric mood | 22.92 | 10.44 | 51 | 102621 | 5590 | 34848669 |
Cytomegalovirus infection | 22.63 | 10.44 | 26 | 102646 | 26109 | 34828150 |
Wrong product administered | 22.55 | 10.44 | 49 | 102623 | 5285 | 34848974 |
Product dispensing error | 22.49 | 10.44 | 54 | 102618 | 6220 | 34848039 |
Hyperaesthesia | 22.45 | 10.44 | 45 | 102627 | 4585 | 34849674 |
Drug screen positive | 22.42 | 10.44 | 41 | 102631 | 3902 | 34850357 |
Neutrophil count decreased | 22.40 | 10.44 | 76 | 102596 | 51028 | 34803231 |
Hyper IgE syndrome | 22.32 | 10.44 | 8 | 102664 | 55 | 34854204 |
Hallucinations, mixed | 22.09 | 10.44 | 33 | 102639 | 2656 | 34851603 |
Appendicitis | 21.95 | 10.44 | 8 | 102664 | 14799 | 34839460 |
Sepsis | 21.77 | 10.44 | 351 | 102321 | 166210 | 34688049 |
Accidental exposure to product by child | 21.41 | 10.44 | 24 | 102648 | 1452 | 34852807 |
Puncture site haematoma | 21.23 | 10.44 | 10 | 102662 | 147 | 34854112 |
Suicidal behaviour | 21.13 | 10.44 | 24 | 102648 | 1473 | 34852786 |
Graft versus host disease | 21.04 | 10.44 | 3 | 102669 | 10566 | 34843693 |
Body mass index abnormal | 20.87 | 10.44 | 10 | 102662 | 153 | 34854106 |
Road traffic accident | 20.86 | 10.44 | 104 | 102568 | 17346 | 34836913 |
Neutropenia neonatal | 20.72 | 10.44 | 17 | 102655 | 695 | 34853564 |
Pulmonary oedema | 20.62 | 10.44 | 222 | 102450 | 47307 | 34806952 |
Pneumonia | 20.29 | 10.44 | 865 | 101807 | 361762 | 34492497 |
Palmoplantar pustulosis | 20.16 | 10.44 | 9 | 102663 | 116 | 34854143 |
Drug withdrawal syndrome neonatal | 19.78 | 10.44 | 37 | 102635 | 3582 | 34850677 |
Hypoosmolar state | 19.69 | 10.44 | 9 | 102663 | 123 | 34854136 |
Dyspnoea | 19.60 | 10.44 | 906 | 101766 | 375876 | 34478383 |
Vascular malformation | 19.54 | 10.44 | 8 | 102664 | 82 | 34854177 |
Physical deconditioning | 19.54 | 10.44 | 22 | 102650 | 1337 | 34852922 |
Substance use disorder | 19.38 | 10.44 | 17 | 102655 | 762 | 34853497 |
Decompression sickness | 19.33 | 10.44 | 4 | 102668 | 0 | 34854259 |
Product administration error | 19.25 | 10.44 | 97 | 102575 | 16247 | 34838012 |
Wheezing | 19.24 | 10.44 | 60 | 102612 | 41342 | 34812917 |
Insomnia | 18.74 | 10.44 | 418 | 102254 | 103489 | 34750770 |
Hypopnoea | 18.67 | 10.44 | 28 | 102644 | 2261 | 34851998 |
Multiple organ dysfunction syndrome | 18.57 | 10.44 | 140 | 102532 | 76426 | 34777833 |
Drug detoxification | 18.53 | 10.44 | 11 | 102661 | 264 | 34853995 |
Post stroke epilepsy | 18.38 | 10.44 | 5 | 102667 | 11 | 34854248 |
Discoloured vomit | 18.36 | 10.44 | 14 | 102658 | 514 | 34853745 |
Sleep disorder | 18.18 | 10.44 | 157 | 102515 | 31531 | 34822728 |
Urethral valves | 18.14 | 10.44 | 11 | 102661 | 275 | 34853984 |
Inappropriate schedule of product administration | 18.06 | 10.44 | 108 | 102564 | 62188 | 34792071 |
Bladder cancer | 17.89 | 10.44 | 13 | 102659 | 16265 | 34837994 |
Inflammation | 17.85 | 10.44 | 35 | 102637 | 28260 | 34825999 |
Oesophageal carcinoma | 17.70 | 10.44 | 3 | 102669 | 9301 | 34844958 |
Neuroleptic malignant syndrome | 17.62 | 10.44 | 16 | 102656 | 17918 | 34836341 |
Logorrhoea | 17.45 | 10.44 | 28 | 102644 | 2398 | 34851861 |
Acidosis | 17.41 | 10.44 | 71 | 102601 | 10874 | 34843385 |
Spinal operation | 17.23 | 10.44 | 31 | 102641 | 2913 | 34851346 |
Substance abuser | 17.21 | 10.44 | 8 | 102664 | 114 | 34854145 |
Fall | 17.15 | 10.44 | 744 | 101928 | 202141 | 34652118 |
Polyneuropathy in malignant disease | 17.04 | 10.44 | 10 | 102662 | 235 | 34854024 |
Change of bowel habit | 16.94 | 10.44 | 18 | 102654 | 1025 | 34853234 |
Aspartate aminotransferase increased | 16.88 | 10.44 | 123 | 102549 | 67660 | 34786599 |
Faecaloma | 16.88 | 10.44 | 44 | 102628 | 5333 | 34848926 |
Aplastic anaemia | 16.68 | 10.44 | 4 | 102668 | 9712 | 34844547 |
Nightmare | 16.66 | 10.44 | 85 | 102587 | 14306 | 34839953 |
Product substitution | 16.65 | 10.44 | 6 | 102666 | 42 | 34854217 |
Product storage error | 16.51 | 10.44 | 57 | 102615 | 8065 | 34846194 |
Acute cutaneous lupus erythematosus | 16.51 | 10.44 | 7 | 102665 | 79 | 34854180 |
Intentional self-injury | 16.41 | 10.44 | 82 | 102590 | 13689 | 34840570 |
Hepatic function abnormal | 16.21 | 10.44 | 71 | 102601 | 44292 | 34809967 |
Visceral congestion | 16.18 | 10.44 | 14 | 102658 | 616 | 34853643 |
Bone marrow failure | 16.13 | 10.44 | 39 | 102633 | 29214 | 34825045 |
Faecal disimpaction | 15.99 | 10.44 | 5 | 102667 | 21 | 34854238 |
Renal impairment | 15.98 | 10.44 | 189 | 102483 | 94324 | 34759935 |
Disease recurrence | 15.92 | 10.44 | 24 | 102648 | 21466 | 34832793 |
Nausea | 15.60 | 10.44 | 1179 | 101493 | 338729 | 34515530 |
Suicidal ideation | 15.42 | 10.44 | 184 | 102488 | 40204 | 34814055 |
Ligament calcification | 15.35 | 10.44 | 9 | 102663 | 211 | 34854048 |
Gastric bypass | 15.27 | 10.44 | 10 | 102662 | 287 | 34853972 |
Leukopenia | 15.20 | 10.44 | 115 | 102557 | 62741 | 34791518 |
Condition aggravated | 15.19 | 10.44 | 439 | 102233 | 191757 | 34662502 |
Stoma site pain | 15.19 | 10.44 | 14 | 102658 | 670 | 34853589 |
Haemorrhagic fever | 14.96 | 10.44 | 5 | 102667 | 27 | 34854232 |
Oesophagitis chemical | 14.88 | 10.44 | 6 | 102666 | 59 | 34854200 |
Tooth injury | 14.82 | 10.44 | 18 | 102654 | 1187 | 34853072 |
Wrong technique in product usage process | 14.78 | 10.44 | 55 | 102617 | 35931 | 34818328 |
Death | 14.67 | 10.44 | 1358 | 101314 | 396691 | 34457568 |
Full blood count abnormal | 14.67 | 10.44 | 20 | 102652 | 18648 | 34835611 |
Cardiac failure congestive | 14.67 | 10.44 | 165 | 102507 | 83105 | 34771154 |
Aggression | 14.65 | 10.44 | 177 | 102495 | 38787 | 34815472 |
Therapy partial responder | 14.59 | 10.44 | 5 | 102667 | 9611 | 34844648 |
Transplant rejection | 14.57 | 10.44 | 6 | 102666 | 10305 | 34843954 |
Femoral artery aneurysm | 14.56 | 10.44 | 8 | 102664 | 165 | 34854094 |
Inappropriate antidiuretic hormone secretion | 14.54 | 10.44 | 75 | 102597 | 12678 | 34841581 |
Aspergillus infection | 14.52 | 10.44 | 9 | 102663 | 12245 | 34842014 |
Hanging | 14.52 | 10.44 | 8 | 102664 | 166 | 34854093 |
Injection site pain | 14.51 | 10.44 | 62 | 102610 | 38943 | 34815316 |
Epilepsy with myoclonic-atonic seizures | 14.50 | 10.44 | 3 | 102669 | 0 | 34854259 |
Lumbar radiculopathy | 14.48 | 10.44 | 15 | 102657 | 829 | 34853430 |
Hepatic cytolysis | 14.33 | 10.44 | 82 | 102590 | 14414 | 34839845 |
Drug reaction with eosinophilia and systemic symptoms | 14.23 | 10.44 | 154 | 102518 | 32858 | 34821401 |
Hyperinsulinaemia | 14.20 | 10.44 | 6 | 102666 | 67 | 34854192 |
Influenza virus test positive | 14.16 | 10.44 | 7 | 102665 | 115 | 34854144 |
Dehydration | 14.09 | 10.44 | 283 | 102389 | 129686 | 34724573 |
Schizophrenia | 14.05 | 10.44 | 4 | 102668 | 8662 | 34845597 |
Perineal infection | 14.04 | 10.44 | 13 | 102659 | 626 | 34853633 |
Ventricular fibrillation | 13.96 | 10.44 | 29 | 102643 | 22925 | 34831334 |
Theft | 13.90 | 10.44 | 9 | 102663 | 253 | 34854006 |
Ascites | 13.89 | 10.44 | 80 | 102592 | 46491 | 34807768 |
Somnambulism | 13.88 | 10.44 | 29 | 102643 | 3043 | 34851216 |
Quality of life decreased | 13.88 | 10.44 | 34 | 102638 | 3967 | 34850292 |
Scrotal infection | 13.80 | 10.44 | 13 | 102659 | 640 | 34853619 |
White blood cell count increased | 13.77 | 10.44 | 68 | 102604 | 41083 | 34813176 |
Anxiety | 13.76 | 10.44 | 386 | 102286 | 99042 | 34755217 |
Lymphoma | 13.73 | 10.44 | 10 | 102662 | 12497 | 34841762 |
Chemical poisoning | 13.69 | 10.44 | 7 | 102665 | 124 | 34854135 |
Anaemia | 13.56 | 10.44 | 554 | 102118 | 232781 | 34621478 |
Reversible cerebral vasoconstriction syndrome | 13.48 | 10.44 | 11 | 102661 | 446 | 34853813 |
Blood creatinine increased | 13.46 | 10.44 | 197 | 102475 | 94779 | 34759480 |
Haemophagocytic lymphohistiocytosis | 13.44 | 10.44 | 11 | 102661 | 12962 | 34841297 |
Haematocrit decreased | 13.39 | 10.44 | 49 | 102623 | 32167 | 34822092 |
Osteoarthritis | 13.30 | 10.44 | 105 | 102567 | 20537 | 34833722 |
Dyspnoea exertional | 13.09 | 10.44 | 74 | 102598 | 43205 | 34811054 |
Myocardial infarction | 13.02 | 10.44 | 264 | 102408 | 120821 | 34733438 |
Eosinophilic pneumonia chronic | 12.93 | 10.44 | 9 | 102663 | 286 | 34853973 |
Major depression | 12.93 | 10.44 | 36 | 102636 | 4536 | 34849723 |
Allodynia | 12.90 | 10.44 | 14 | 102658 | 817 | 34853442 |
Abnormal sleep-related event | 12.87 | 10.44 | 11 | 102661 | 476 | 34853783 |
Increased appetite | 12.87 | 10.44 | 3 | 102669 | 7426 | 34846833 |
Optic nerve operation | 12.81 | 10.44 | 11 | 102661 | 479 | 34853780 |
Pleural mesothelioma | 12.81 | 10.44 | 6 | 102666 | 87 | 34854172 |
Respiratory rate decreased | 12.75 | 10.44 | 24 | 102648 | 2335 | 34851924 |
Back pain | 12.71 | 10.44 | 457 | 102215 | 121332 | 34732927 |
Dermal cyst | 12.68 | 10.44 | 21 | 102651 | 1846 | 34852413 |
Blood glucose increased | 12.63 | 10.44 | 130 | 102542 | 66588 | 34787671 |
Immune reconstitution inflammatory syndrome | 12.54 | 10.44 | 5 | 102667 | 8754 | 34845505 |
Capillary fragility | 12.50 | 10.44 | 5 | 102667 | 48 | 34854211 |
Rash | 12.49 | 10.44 | 531 | 102141 | 222221 | 34632038 |
Therapeutic product effect decreased | 12.45 | 10.44 | 56 | 102616 | 34687 | 34819572 |
Central-alveolar hypoventilation | 12.43 | 10.44 | 3 | 102669 | 3 | 34854256 |
Victim of sexual abuse | 12.43 | 10.44 | 3 | 102669 | 3 | 34854256 |
Hydroxyprolinuria | 12.43 | 10.44 | 3 | 102669 | 3 | 34854256 |
Spleen congestion | 12.40 | 10.44 | 9 | 102663 | 306 | 34853953 |
Eosinophilic fasciitis | 12.40 | 10.44 | 6 | 102666 | 94 | 34854165 |
Torsade de pointes | 12.31 | 10.44 | 3 | 102669 | 7206 | 34847053 |
Arterial spasm | 12.28 | 10.44 | 6 | 102666 | 96 | 34854163 |
Antiphospholipid antibodies positive | 12.27 | 10.44 | 9 | 102663 | 311 | 34853948 |
Weaning failure | 12.11 | 10.44 | 8 | 102664 | 233 | 34854026 |
Blood urea increased | 12.09 | 10.44 | 47 | 102625 | 30317 | 34823942 |
Interstitial lung disease | 12.03 | 10.44 | 128 | 102544 | 65154 | 34789105 |
Poor feeding infant | 11.94 | 10.44 | 11 | 102661 | 526 | 34853733 |
Haematuria | 11.92 | 10.44 | 92 | 102580 | 49974 | 34804285 |
Hyperthermia | 11.91 | 10.44 | 62 | 102610 | 10515 | 34843744 |
Cerebral infarction | 11.91 | 10.44 | 41 | 102631 | 27414 | 34826845 |
Sweat gland disorder | 11.91 | 10.44 | 6 | 102666 | 103 | 34854156 |
Bronchiectasis | 11.89 | 10.44 | 7 | 102665 | 9794 | 34844465 |
Bladder dilatation | 11.81 | 10.44 | 18 | 102654 | 1474 | 34852785 |
Ichthyosis | 11.80 | 10.44 | 6 | 102666 | 105 | 34854154 |
Congenital heart valve disorder | 11.75 | 10.44 | 5 | 102667 | 57 | 34854202 |
Intervertebral disc protrusion | 11.66 | 10.44 | 59 | 102613 | 9897 | 34844362 |
Blood lactate dehydrogenase increased | 11.63 | 10.44 | 32 | 102640 | 22958 | 34831301 |
Social anxiety disorder | 11.56 | 10.44 | 9 | 102663 | 341 | 34853918 |
Therapeutic drug monitoring analysis not performed | 11.47 | 10.44 | 11 | 102661 | 554 | 34853705 |
Cardio-respiratory arrest | 11.46 | 10.44 | 227 | 102445 | 55046 | 34799213 |
Stress | 11.43 | 10.44 | 48 | 102624 | 30299 | 34823960 |
Tongue injury | 11.41 | 10.44 | 6 | 102666 | 113 | 34854146 |
Hepatic cancer | 11.40 | 10.44 | 5 | 102667 | 8270 | 34845989 |
Thrombocytopenia | 11.33 | 10.44 | 361 | 102311 | 155886 | 34698373 |
Asthma | 11.31 | 10.44 | 76 | 102596 | 42580 | 34811679 |
Visceral pain | 11.30 | 10.44 | 5 | 102667 | 63 | 34854196 |
Limb fracture | 11.22 | 10.44 | 4 | 102668 | 27 | 34854232 |
Otospondylomegaepiphyseal dysplasia | 11.18 | 10.44 | 6 | 102666 | 118 | 34854141 |
Pre-existing condition improved | 11.17 | 10.44 | 24 | 102648 | 2568 | 34851691 |
Perineal pain | 11.16 | 10.44 | 13 | 102659 | 820 | 34853439 |
Lentigo maligna | 11.16 | 10.44 | 9 | 102663 | 359 | 34853900 |
Renal tubular necrosis | 11.15 | 10.44 | 18 | 102654 | 15662 | 34838597 |
Ejection fraction decreased | 10.99 | 10.44 | 25 | 102647 | 19129 | 34835130 |
Product appearance confusion | 10.98 | 10.44 | 4 | 102668 | 29 | 34854230 |
Neuralgia | 10.94 | 10.44 | 79 | 102593 | 15034 | 34839225 |
Pseudoporphyria | 10.86 | 10.44 | 9 | 102663 | 373 | 34853886 |
Restless legs syndrome | 10.86 | 10.44 | 51 | 102621 | 8303 | 34845956 |
Arthrofibrosis | 10.83 | 10.44 | 5 | 102667 | 70 | 34854189 |
Oxygen saturation decreased | 10.82 | 10.44 | 220 | 102452 | 53598 | 34800661 |
Obstructive airways disorder | 10.82 | 10.44 | 18 | 102654 | 15476 | 34838783 |
Haemodialysis | 10.81 | 10.44 | 9 | 102663 | 10517 | 34843742 |
Trigger finger | 10.64 | 10.44 | 13 | 102659 | 862 | 34853397 |
Product dose omission issue | 10.60 | 10.44 | 269 | 102403 | 119442 | 34734817 |
Spinal disorder | 10.60 | 10.44 | 32 | 102640 | 4220 | 34850039 |
Impaired reasoning | 10.58 | 10.44 | 6 | 102666 | 132 | 34854127 |
Pulmonary congestion | 10.57 | 10.44 | 73 | 102599 | 13692 | 34840567 |
Dyschezia | 10.55 | 10.44 | 17 | 102655 | 1461 | 34852798 |
Drug withdrawal convulsions | 10.47 | 10.44 | 15 | 102657 | 1162 | 34853097 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 1198.93 | 9.51 | 2060 | 270324 | 160631 | 79311373 |
Drug dependence | 1181.78 | 9.51 | 1035 | 271349 | 39734 | 79432270 |
Serotonin syndrome | 1066.82 | 9.51 | 1021 | 271363 | 44006 | 79427998 |
Poisoning deliberate | 995.78 | 9.51 | 683 | 271701 | 18145 | 79453859 |
Toxicity to various agents | 993.60 | 9.51 | 3429 | 268955 | 418111 | 79053893 |
Coma | 631.46 | 9.51 | 1189 | 271195 | 99460 | 79372544 |
Intentional overdose | 525.27 | 9.51 | 1135 | 271249 | 104825 | 79367179 |
Overdose | 513.97 | 9.51 | 1589 | 270795 | 182617 | 79289387 |
Drug use disorder | 431.97 | 9.51 | 303 | 272081 | 8348 | 79463656 |
Withdrawal syndrome | 426.42 | 9.51 | 492 | 271892 | 26362 | 79445642 |
Completed suicide | 412.63 | 9.51 | 1798 | 270586 | 243969 | 79228035 |
Intentional product misuse | 400.00 | 9.51 | 955 | 271429 | 94210 | 79377794 |
Bradypnoea | 388.96 | 9.51 | 248 | 272136 | 5804 | 79466200 |
Somnolence | 380.48 | 9.51 | 1721 | 270663 | 237260 | 79234744 |
Miosis | 373.74 | 9.51 | 358 | 272026 | 15431 | 79456573 |
Respiratory depression | 322.77 | 9.51 | 434 | 271950 | 27196 | 79444808 |
Drug withdrawal syndrome | 271.58 | 9.51 | 452 | 271932 | 34266 | 79437738 |
Off label use | 252.73 | 9.51 | 1940 | 270444 | 905275 | 78566729 |
Mydriasis | 233.90 | 9.51 | 295 | 272089 | 17348 | 79454656 |
Suicide attempt | 218.68 | 9.51 | 702 | 271682 | 82230 | 79389774 |
Prescription form tampering | 216.25 | 9.51 | 72 | 272312 | 320 | 79471684 |
Drug hypersensitivity | 206.87 | 9.51 | 1735 | 270649 | 297181 | 79174823 |
Drug interaction | 186.64 | 9.51 | 2203 | 270181 | 412980 | 79059024 |
Pemphigus | 179.69 | 9.51 | 58 | 272326 | 99524 | 79372480 |
Hepatocellular injury | 163.82 | 9.51 | 443 | 271941 | 47150 | 79424854 |
Generalised tonic-clonic seizure | 163.64 | 9.51 | 421 | 271963 | 43489 | 79428515 |
Seizure | 162.22 | 9.51 | 1153 | 271231 | 187681 | 79284323 |
Confusional state | 160.78 | 9.51 | 1727 | 270657 | 316270 | 79155734 |
Sensitisation | 158.43 | 9.51 | 113 | 272271 | 3198 | 79468806 |
Asphyxia | 157.00 | 9.51 | 197 | 272187 | 11523 | 79460481 |
Treatment failure | 155.36 | 9.51 | 213 | 272171 | 170273 | 79301731 |
Polycystic ovaries | 147.26 | 9.51 | 114 | 272270 | 3665 | 79468339 |
Hand deformity | 142.97 | 9.51 | 89 | 272295 | 103830 | 79368174 |
Synovitis | 138.67 | 9.51 | 187 | 272197 | 150547 | 79321457 |
Infusion related reaction | 135.51 | 9.51 | 373 | 272011 | 229864 | 79242140 |
Drug abuser | 130.44 | 9.51 | 130 | 272254 | 5883 | 79466121 |
Ejection fraction | 126.33 | 9.51 | 85 | 272299 | 2184 | 79469820 |
Drug ineffective | 125.70 | 9.51 | 2777 | 269607 | 1078136 | 78393868 |
Prescription drug used without a prescription | 124.94 | 9.51 | 107 | 272277 | 3978 | 79468026 |
Contraindicated product administered | 124.22 | 9.51 | 217 | 272167 | 157321 | 79314683 |
Glossodynia | 123.22 | 9.51 | 103 | 272281 | 103234 | 79368770 |
Poisoning | 122.00 | 9.51 | 268 | 272116 | 25004 | 79447000 |
Anti-cyclic citrullinated peptide antibody positive | 120.31 | 9.51 | 67 | 272317 | 83076 | 79388928 |
Joint swelling | 120.01 | 9.51 | 542 | 271842 | 288104 | 79183900 |
Pericarditis | 119.32 | 9.51 | 108 | 272276 | 104128 | 79367876 |
Cholestasis | 113.57 | 9.51 | 414 | 271970 | 51695 | 79420309 |
Drug detoxification | 106.37 | 9.51 | 43 | 272341 | 360 | 79471644 |
Maternal exposure during pregnancy | 105.90 | 9.51 | 190 | 272194 | 136348 | 79335656 |
Systemic lupus erythematosus | 103.81 | 9.51 | 158 | 272226 | 120991 | 79351013 |
Vomiting | 100.03 | 9.51 | 2978 | 269406 | 662850 | 78809154 |
Drug intolerance | 95.93 | 9.51 | 520 | 271864 | 263599 | 79208405 |
Fall | 94.43 | 9.51 | 2255 | 270129 | 485374 | 78986630 |
Gastrointestinal pain | 90.38 | 9.51 | 138 | 272246 | 9717 | 79462287 |
Hallucination, visual | 88.01 | 9.51 | 279 | 272105 | 32450 | 79439554 |
Rash | 87.24 | 9.51 | 1420 | 270964 | 576938 | 78895066 |
Disorientation | 87.23 | 9.51 | 435 | 271949 | 62341 | 79409663 |
Helicobacter infection | 86.19 | 9.51 | 67 | 272317 | 69637 | 79402367 |
Therapeutic product effect decreased | 85.92 | 9.51 | 280 | 272104 | 163583 | 79308421 |
Hepatic enzyme increased | 83.17 | 9.51 | 331 | 272053 | 182279 | 79289725 |
Myoclonus | 82.98 | 9.51 | 245 | 272139 | 27415 | 79444589 |
Analgesic drug level increased | 82.77 | 9.51 | 76 | 272308 | 3102 | 79468902 |
Deafness transitory | 82.50 | 9.51 | 48 | 272336 | 947 | 79471057 |
Wound | 81.13 | 9.51 | 172 | 272212 | 116007 | 79355997 |
Drug resistance | 80.85 | 9.51 | 22 | 272362 | 42191 | 79429813 |
Derealisation | 80.56 | 9.51 | 57 | 272327 | 1592 | 79470412 |
Rheumatoid factor positive | 79.90 | 9.51 | 53 | 272331 | 59786 | 79412218 |
Febrile neutropenia | 79.41 | 9.51 | 463 | 271921 | 230536 | 79241468 |
Duodenal ulcer perforation | 78.92 | 9.51 | 66 | 272318 | 66145 | 79405859 |
Hallucination | 78.53 | 9.51 | 532 | 271852 | 85213 | 79386791 |
Hypoglycaemia | 78.43 | 9.51 | 605 | 271779 | 100989 | 79371015 |
Loss of consciousness | 78.29 | 9.51 | 898 | 271486 | 167045 | 79304959 |
Rhinitis allergic | 76.91 | 9.51 | 145 | 272239 | 12124 | 79459880 |
Pyrexia | 76.19 | 9.51 | 1752 | 270632 | 676957 | 78795047 |
Discomfort | 75.75 | 9.51 | 201 | 272183 | 125416 | 79346588 |
Alopecia | 74.66 | 9.51 | 473 | 271911 | 230882 | 79241122 |
Carpal tunnel syndrome | 74.58 | 9.51 | 189 | 272195 | 19339 | 79452665 |
Dependence | 73.18 | 9.51 | 63 | 272321 | 2359 | 79469645 |
Depressed level of consciousness | 72.64 | 9.51 | 572 | 271812 | 96080 | 79375924 |
Wrong patient received product | 72.27 | 9.51 | 84 | 272300 | 4534 | 79467470 |
Agitation | 69.99 | 9.51 | 581 | 271803 | 99134 | 79372870 |
Respiratory acidosis | 69.75 | 9.51 | 132 | 272252 | 11068 | 79460936 |
Hyperacusis | 67.52 | 9.51 | 58 | 272326 | 2165 | 79469839 |
Blood test abnormal | 67.21 | 9.51 | 171 | 272213 | 17539 | 79454465 |
Myelosuppression | 66.68 | 9.51 | 27 | 272357 | 40269 | 79431735 |
Death | 66.27 | 9.51 | 2461 | 269923 | 564053 | 78907951 |
Depersonalisation/derealisation disorder | 65.74 | 9.51 | 53 | 272331 | 1809 | 79470195 |
Epilepsy | 64.65 | 9.51 | 294 | 272090 | 40566 | 79431438 |
Cardio-respiratory arrest | 64.17 | 9.51 | 609 | 271775 | 107901 | 79364103 |
Urinary retention | 64.11 | 9.51 | 371 | 272013 | 56259 | 79415745 |
Hyperhidrosis | 62.70 | 9.51 | 792 | 271592 | 150700 | 79321304 |
Burning sensation | 62.44 | 9.51 | 378 | 272006 | 58254 | 79413750 |
Constipation | 61.23 | 9.51 | 1330 | 271054 | 281720 | 79190284 |
Minimum inhibitory concentration | 60.92 | 9.51 | 23 | 272361 | 157 | 79471847 |
Red blood cell sedimentation rate increased | 60.92 | 9.51 | 41 | 272343 | 45901 | 79426103 |
Sleep apnoea syndrome | 60.37 | 9.51 | 266 | 272118 | 36212 | 79435792 |
Red blood cell sedimentation rate abnormal | 59.10 | 9.51 | 3 | 272381 | 20960 | 79451044 |
Antimicrobial susceptibility test resistant | 58.74 | 9.51 | 28 | 272356 | 360 | 79471644 |
Gastric pH decreased | 56.17 | 9.51 | 36 | 272348 | 850 | 79471154 |
Inadequate analgesia | 56.03 | 9.51 | 74 | 272310 | 4555 | 79467449 |
Disease progression | 55.90 | 9.51 | 384 | 272000 | 183978 | 79288026 |
Muscle injury | 54.75 | 9.51 | 51 | 272333 | 48510 | 79423494 |
Cytomegalovirus infection | 53.98 | 9.51 | 40 | 272344 | 42604 | 79429400 |
Hallucinations, mixed | 52.84 | 9.51 | 89 | 272295 | 6810 | 79465194 |
Accidental overdose | 52.68 | 9.51 | 271 | 272113 | 39310 | 79432694 |
Hypersensitivity | 52.31 | 9.51 | 608 | 271776 | 261631 | 79210373 |
Drug diversion | 51.54 | 9.51 | 39 | 272345 | 1211 | 79470793 |
Product use in unapproved indication | 51.28 | 9.51 | 577 | 271807 | 249782 | 79222222 |
Apnoea | 50.80 | 9.51 | 119 | 272265 | 11585 | 79460419 |
Drug dispensed to wrong patient | 50.58 | 9.51 | 31 | 272353 | 675 | 79471329 |
Device expulsion | 50.43 | 9.51 | 13 | 272371 | 25848 | 79446156 |
Nausea | 50.35 | 9.51 | 3856 | 268528 | 953340 | 78518664 |
Platelet count decreased | 49.80 | 9.51 | 425 | 271959 | 194239 | 79277765 |
Clonus | 49.44 | 9.51 | 86 | 272298 | 6754 | 79465250 |
C-reactive protein increased | 47.92 | 9.51 | 252 | 272132 | 128775 | 79343229 |
Ejection fraction abnormal | 47.92 | 9.51 | 50 | 272334 | 2390 | 79469614 |
Suicidal ideation | 47.92 | 9.51 | 434 | 271950 | 75906 | 79396098 |
Shoulder arthroplasty | 46.91 | 9.51 | 57 | 272327 | 3225 | 79468779 |
Exposure during pregnancy | 46.86 | 9.51 | 182 | 272202 | 100950 | 79371054 |
Abdominal discomfort | 46.69 | 9.51 | 590 | 271794 | 250137 | 79221867 |
Folliculitis | 46.68 | 9.51 | 73 | 272311 | 55307 | 79416697 |
Arthropathy | 45.16 | 9.51 | 387 | 271997 | 176724 | 79295280 |
Housebound | 44.95 | 9.51 | 25 | 272359 | 451 | 79471553 |
Infection | 44.56 | 9.51 | 570 | 271814 | 241142 | 79230862 |
Ankylosing spondylitis | 44.41 | 9.51 | 116 | 272268 | 12089 | 79459915 |
Behaviour disorder | 43.86 | 9.51 | 78 | 272306 | 6235 | 79465769 |
Depression | 43.50 | 9.51 | 1008 | 271376 | 215782 | 79256222 |
Functional gastrointestinal disorder | 43.14 | 9.51 | 68 | 272316 | 4922 | 79467082 |
Visceral congestion | 42.04 | 9.51 | 31 | 272353 | 925 | 79471079 |
Intentional product use issue | 41.69 | 9.51 | 326 | 272058 | 151786 | 79320218 |
Haemoglobin decreased | 41.61 | 9.51 | 522 | 271862 | 221597 | 79250407 |
Decorticate posture | 40.84 | 9.51 | 21 | 272363 | 321 | 79471683 |
Leukopenia | 40.29 | 9.51 | 233 | 272151 | 116280 | 79355724 |
Altered state of consciousness | 40.17 | 9.51 | 272 | 272112 | 43550 | 79428454 |
Myocardial depression | 39.88 | 9.51 | 24 | 272360 | 505 | 79471499 |
Delirium | 39.62 | 9.51 | 453 | 271931 | 84174 | 79387830 |
Multiple organ dysfunction syndrome | 39.19 | 9.51 | 245 | 272139 | 120001 | 79352003 |
Nephrectomy | 39.16 | 9.51 | 42 | 272342 | 2073 | 79469931 |
Cyanosis | 38.95 | 9.51 | 180 | 272204 | 25002 | 79447002 |
Hepatic function abnormal | 38.94 | 9.51 | 124 | 272260 | 72983 | 79399021 |
Feeling of despair | 38.71 | 9.51 | 48 | 272336 | 2773 | 79469231 |
Impaired healing | 38.56 | 9.51 | 161 | 272223 | 87494 | 79384510 |
Tonic clonic movements | 38.51 | 9.51 | 43 | 272341 | 2221 | 79469783 |
Sacroiliitis | 37.91 | 9.51 | 55 | 272329 | 3699 | 79468305 |
Rheumatoid nodule | 37.58 | 9.51 | 7 | 272377 | 17431 | 79454573 |
Vertigo | 37.55 | 9.51 | 381 | 272003 | 68701 | 79403303 |
Multiple drug therapy | 37.25 | 9.51 | 57 | 272327 | 4021 | 79467983 |
Blood creatinine increased | 37.25 | 9.51 | 344 | 272040 | 154713 | 79317291 |
Peripheral circulatory failure | 37.07 | 9.51 | 31 | 272353 | 1115 | 79470889 |
Renal impairment | 37.06 | 9.51 | 352 | 272032 | 157431 | 79314573 |
Mycotic allergy | 37.00 | 9.51 | 35 | 272349 | 1484 | 79470520 |
Sphincter of Oddi dysfunction | 36.20 | 9.51 | 21 | 272363 | 412 | 79471592 |
Transplant rejection | 35.62 | 9.51 | 11 | 272373 | 19426 | 79452578 |
Disease recurrence | 35.44 | 9.51 | 60 | 272324 | 44049 | 79427955 |
Therapeutic response delayed | 35.10 | 9.51 | 30 | 272354 | 1112 | 79470892 |
Nightmare | 35.07 | 9.51 | 178 | 272206 | 25683 | 79446321 |
Cough | 34.79 | 9.51 | 970 | 271414 | 365819 | 79106185 |
Victim of sexual abuse | 34.68 | 9.51 | 22 | 272362 | 510 | 79471494 |
COVID-19 | 34.43 | 9.51 | 358 | 272026 | 157316 | 79314688 |
Pneumonia | 34.10 | 9.51 | 1876 | 270508 | 658370 | 78813634 |
Abnormal loss of weight | 34.02 | 9.51 | 83 | 272301 | 8293 | 79463711 |
Analgesic drug level above therapeutic | 33.83 | 9.51 | 21 | 272363 | 468 | 79471536 |
Neutropenia | 33.49 | 9.51 | 738 | 271646 | 286972 | 79185032 |
Faecaloma | 33.33 | 9.51 | 101 | 272283 | 11463 | 79460541 |
Anxiety | 33.29 | 9.51 | 1097 | 271287 | 247415 | 79224589 |
Eyelid myoclonus | 33.11 | 9.51 | 13 | 272371 | 100 | 79471904 |
Euphoric mood | 32.93 | 9.51 | 78 | 272306 | 7648 | 79464356 |
Product use issue | 32.91 | 9.51 | 511 | 271873 | 209311 | 79262693 |
Pathogen resistance | 32.58 | 9.51 | 5 | 272379 | 14337 | 79457667 |
Cryopyrin associated periodic syndrome | 32.43 | 9.51 | 19 | 272365 | 380 | 79471624 |
Wrong technique in product usage process | 32.30 | 9.51 | 136 | 272248 | 73739 | 79398265 |
Bone marrow failure | 32.16 | 9.51 | 80 | 272304 | 51027 | 79420977 |
Respiratory arrest | 32.05 | 9.51 | 319 | 272065 | 57231 | 79414773 |
Sleep disorder due to general medical condition, insomnia type | 31.65 | 9.51 | 63 | 272321 | 43493 | 79428511 |
Unresponsive to stimuli | 31.44 | 9.51 | 310 | 272074 | 55478 | 79416526 |
Somatic symptom disorder | 31.39 | 9.51 | 41 | 272343 | 2496 | 79469508 |
Obstructive airways disorder | 31.02 | 9.51 | 37 | 272347 | 31422 | 79440582 |
Inappropriate antidiuretic hormone secretion | 30.84 | 9.51 | 174 | 272210 | 26139 | 79445865 |
Disturbance in attention | 30.46 | 9.51 | 286 | 272098 | 50515 | 79421489 |
Narcotic bowel syndrome | 30.03 | 9.51 | 16 | 272368 | 264 | 79471740 |
Hyponatraemia | 30.03 | 9.51 | 808 | 271576 | 177040 | 79294964 |
Feeling of body temperature change | 29.80 | 9.51 | 60 | 272324 | 5266 | 79466738 |
Pancreatic fibrosis | 29.73 | 9.51 | 12 | 272372 | 100 | 79471904 |
Alanine aminotransferase increased | 29.71 | 9.51 | 384 | 272000 | 162186 | 79309818 |
Dissociation | 29.64 | 9.51 | 51 | 272333 | 3970 | 79468034 |
Thrombotic microangiopathy | 29.54 | 9.51 | 16 | 272368 | 20153 | 79451851 |
Speech disorder | 29.45 | 9.51 | 300 | 272084 | 54145 | 79417859 |
Psychotic disorder due to a general medical condition | 29.45 | 9.51 | 16 | 272368 | 275 | 79471729 |
Creatinine renal clearance decreased | 29.44 | 9.51 | 14 | 272370 | 18988 | 79453016 |
Pancreatitis acute | 29.11 | 9.51 | 278 | 272106 | 49326 | 79422678 |
Fibromyalgia | 29.04 | 9.51 | 342 | 272042 | 63998 | 79408006 |
Feeding disorder | 28.79 | 9.51 | 121 | 272263 | 16133 | 79455871 |
Expired product administered | 28.77 | 9.51 | 70 | 272314 | 6981 | 79465023 |
Premature delivery | 28.45 | 9.51 | 23 | 272361 | 23444 | 79448560 |
White blood cell count decreased | 28.37 | 9.51 | 462 | 271922 | 187826 | 79284178 |
Interstitial lung disease | 28.26 | 9.51 | 247 | 272137 | 112353 | 79359651 |
Cytomegalovirus viraemia | 27.95 | 9.51 | 5 | 272379 | 12816 | 79459188 |
Acute generalised exanthematous pustulosis | 27.93 | 9.51 | 125 | 272259 | 17129 | 79454875 |
Gastrooesophageal reflux disease | 27.92 | 9.51 | 506 | 271878 | 103740 | 79368264 |
Neutrophil count decreased | 27.82 | 9.51 | 197 | 272187 | 93762 | 79378242 |
Restless legs syndrome | 27.74 | 9.51 | 139 | 272245 | 19953 | 79452051 |
Eosinophil count increased | 27.44 | 9.51 | 12 | 272372 | 17093 | 79454911 |
Cestode infection | 27.35 | 9.51 | 15 | 272369 | 263 | 79471741 |
Blood pressure increased | 27.28 | 9.51 | 533 | 271851 | 210827 | 79261177 |
H1N1 influenza | 27.05 | 9.51 | 38 | 272346 | 2481 | 79469523 |
Hyperlipasaemia | 26.99 | 9.51 | 27 | 272357 | 1227 | 79470777 |
Aspergillus infection | 26.91 | 9.51 | 16 | 272368 | 19145 | 79452859 |
Epstein-Barr virus infection | 26.71 | 9.51 | 8 | 272376 | 14408 | 79457596 |
Chronic kidney disease | 26.56 | 9.51 | 344 | 272040 | 65810 | 79406194 |
Parasomnia | 26.50 | 9.51 | 19 | 272365 | 542 | 79471462 |
Bladder cancer | 26.46 | 9.51 | 17 | 272367 | 19509 | 79452495 |
Encephalopathy | 26.45 | 9.51 | 349 | 272035 | 67048 | 79404956 |
Breast disorder | 26.32 | 9.51 | 34 | 272350 | 2047 | 79469957 |
Coma scale abnormal | 26.15 | 9.51 | 77 | 272307 | 8601 | 79463403 |
Adrenergic syndrome | 25.98 | 9.51 | 12 | 272372 | 143 | 79471861 |
Sleep disorder due to a general medical condition | 25.85 | 9.51 | 107 | 272277 | 14170 | 79457834 |
Road traffic accident | 25.77 | 9.51 | 245 | 272139 | 43419 | 79428585 |
Irritable bowel syndrome | 25.74 | 9.51 | 117 | 272267 | 62124 | 79409880 |
Haemophagocytic lymphohistiocytosis | 25.73 | 9.51 | 22 | 272362 | 21815 | 79450189 |
Stomatitis | 25.59 | 9.51 | 350 | 272034 | 146407 | 79325597 |
Skin necrosis | 25.55 | 9.51 | 15 | 272369 | 18072 | 79453932 |
Septic shock | 25.52 | 9.51 | 282 | 272102 | 122519 | 79349485 |
Antidepressant drug level above therapeutic | 25.49 | 9.51 | 20 | 272364 | 656 | 79471348 |
Accidental exposure to product by child | 25.47 | 9.51 | 40 | 272344 | 2886 | 79469118 |
Menstrual disorder | 25.41 | 9.51 | 48 | 272336 | 4019 | 79467985 |
Neck pain | 24.97 | 9.51 | 379 | 272005 | 75038 | 79396966 |
Pituitary tumour benign | 24.94 | 9.51 | 37 | 272347 | 2539 | 79469465 |
Fracture | 24.78 | 9.51 | 143 | 272241 | 21658 | 79450346 |
Nephropathy toxic | 24.77 | 9.51 | 20 | 272364 | 20399 | 79451605 |
Muscle spasms | 24.61 | 9.51 | 776 | 271608 | 173954 | 79298050 |
Drug eruption | 24.47 | 9.51 | 73 | 272311 | 43862 | 79428142 |
Victim of chemical submission | 24.44 | 9.51 | 18 | 272366 | 536 | 79471468 |
Bradycardia foetal | 24.43 | 9.51 | 11 | 272373 | 123 | 79471881 |
Cerebral infarction | 23.95 | 9.51 | 78 | 272306 | 45598 | 79426406 |
Prothrombin time shortened | 23.87 | 9.51 | 41 | 272343 | 3187 | 79468817 |
Negative pressure pulmonary oedema | 23.85 | 9.51 | 13 | 272371 | 225 | 79471779 |
Swelling | 23.76 | 9.51 | 561 | 271823 | 216150 | 79255854 |
Acute motor-sensory axonal neuropathy | 23.71 | 9.51 | 16 | 272368 | 413 | 79471591 |
Lower respiratory tract infection | 23.69 | 9.51 | 305 | 272079 | 128915 | 79343089 |
Therapeutic product ineffective | 23.69 | 9.51 | 31 | 272353 | 1891 | 79470113 |
Pneumocystis jirovecii pneumonia | 23.64 | 9.51 | 47 | 272337 | 32461 | 79439543 |
Substance use disorder | 23.59 | 9.51 | 22 | 272362 | 916 | 79471088 |
Blood parathyroid hormone decreased | 23.20 | 9.51 | 4 | 272380 | 10532 | 79461472 |
Tremor | 23.07 | 9.51 | 752 | 271632 | 169331 | 79302673 |
Haemodialysis | 23.05 | 9.51 | 17 | 272367 | 18151 | 79453853 |
Heart rate decreased | 23.05 | 9.51 | 143 | 272241 | 70173 | 79401831 |
Sleep disorder | 22.99 | 9.51 | 416 | 271968 | 85261 | 79386743 |
Oesophageal carcinoma | 22.74 | 9.51 | 5 | 272379 | 11079 | 79460925 |
Thrombocytopenia | 22.52 | 9.51 | 712 | 271672 | 264547 | 79207457 |
Suicidal behaviour | 22.40 | 9.51 | 40 | 272344 | 3207 | 79468797 |
Gait disturbance | 21.93 | 9.51 | 892 | 271492 | 206614 | 79265390 |
Respiratory disorder | 21.90 | 9.51 | 79 | 272305 | 44777 | 79427227 |
Graft versus host disease | 21.89 | 9.51 | 12 | 272372 | 15014 | 79456990 |
Intervertebral disc protrusion | 21.88 | 9.51 | 147 | 272237 | 23474 | 79448530 |
Arteriovenous fistula | 21.81 | 9.51 | 25 | 272359 | 1329 | 79470675 |
Hyperaesthesia | 21.66 | 9.51 | 91 | 272293 | 12131 | 79459873 |
Hypertonia | 21.63 | 9.51 | 64 | 272320 | 7168 | 79464836 |
Ascites | 21.61 | 9.51 | 160 | 272224 | 75402 | 79396602 |
Neuralgia | 21.56 | 9.51 | 191 | 272193 | 33193 | 79438811 |
Blood calcium decreased | 21.46 | 9.51 | 48 | 272336 | 31771 | 79440233 |
Drug screen positive | 21.42 | 9.51 | 57 | 272327 | 6006 | 79465998 |
Congenital central hypoventilation syndrome | 21.42 | 9.51 | 7 | 272377 | 29 | 79471975 |
Headache | 21.28 | 9.51 | 2547 | 269837 | 651225 | 78820779 |
Pneumonia aspiration | 21.20 | 9.51 | 334 | 272050 | 66633 | 79405371 |
Abortion spontaneous | 21.17 | 9.51 | 43 | 272341 | 29464 | 79442540 |
Hepatic cytolysis | 21.11 | 9.51 | 162 | 272222 | 26989 | 79445015 |
Muscle rigidity | 21.05 | 9.51 | 128 | 272256 | 19754 | 79452250 |
Cardiac failure congestive | 20.92 | 9.51 | 351 | 272033 | 142051 | 79329953 |
Central nervous system stimulation | 20.90 | 9.51 | 8 | 272376 | 57 | 79471947 |
Sedation complication | 20.75 | 9.51 | 14 | 272370 | 15655 | 79456349 |
Substance abuse | 20.75 | 9.51 | 81 | 272303 | 10445 | 79461559 |
Mucosal inflammation | 20.69 | 9.51 | 162 | 272222 | 75418 | 79396586 |
Hyperkalaemia | 20.60 | 9.51 | 271 | 272113 | 114127 | 79357877 |
Body mass index abnormal | 20.57 | 9.51 | 12 | 272372 | 238 | 79471766 |
Amnesia | 20.53 | 9.51 | 316 | 272068 | 62741 | 79409263 |
Haematocrit decreased | 20.45 | 9.51 | 124 | 272260 | 61188 | 79410816 |
Frequent bowel movements | 20.39 | 9.51 | 44 | 272340 | 29495 | 79442509 |
Myocardial infarction | 20.36 | 9.51 | 476 | 271908 | 183653 | 79288351 |
Psychomotor skills impaired | 20.32 | 9.51 | 51 | 272333 | 5186 | 79466818 |
Pseudomonas infection | 20.17 | 9.51 | 25 | 272359 | 20878 | 79451126 |
Cogwheel rigidity | 19.98 | 9.51 | 37 | 272347 | 3051 | 79468953 |
Weight increased | 19.97 | 9.51 | 760 | 271624 | 276626 | 79195378 |
Appendicitis | 19.93 | 9.51 | 25 | 272359 | 20769 | 79451235 |
Substance abuser | 19.92 | 9.51 | 10 | 272374 | 145 | 79471859 |
Listless | 19.84 | 9.51 | 42 | 272342 | 3819 | 79468185 |
Allergy test negative | 19.77 | 9.51 | 13 | 272371 | 321 | 79471683 |
Dizziness | 19.72 | 9.51 | 2070 | 270314 | 524371 | 78947633 |
Colorectal cancer | 19.68 | 9.51 | 3 | 272381 | 8644 | 79463360 |
General physical health deterioration | 19.62 | 9.51 | 755 | 271629 | 274483 | 79197521 |
Muscle tone disorder | 19.56 | 9.51 | 10 | 272374 | 151 | 79471853 |
Mixed anxiety and depressive disorder | 19.54 | 9.51 | 14 | 272370 | 399 | 79471605 |
Renal disorder | 19.53 | 9.51 | 225 | 272159 | 41880 | 79430124 |
Emotional disorder | 19.49 | 9.51 | 99 | 272285 | 14288 | 79457716 |
Tachycardia | 19.44 | 9.51 | 767 | 271617 | 177001 | 79295003 |
Persistent genital arousal disorder | 19.27 | 9.51 | 12 | 272372 | 269 | 79471735 |
Condition aggravated | 19.13 | 9.51 | 1463 | 270921 | 499661 | 78972343 |
Inappropriate schedule of product administration | 19.10 | 9.51 | 331 | 272053 | 133297 | 79338707 |
Limb injury | 19.10 | 9.51 | 169 | 272215 | 29359 | 79442645 |
Blister | 19.05 | 9.51 | 290 | 272094 | 119186 | 79352818 |
Parosmia | 19.04 | 9.51 | 60 | 272324 | 6954 | 79465050 |
Accidental death | 19.03 | 9.51 | 44 | 272340 | 4247 | 79467757 |
Deafness | 18.94 | 9.51 | 130 | 272254 | 20907 | 79451097 |
Symmetrical drug-related intertriginous and flexural exanthema | 18.93 | 9.51 | 19 | 272365 | 867 | 79471137 |
Bladder prolapse | 18.87 | 9.51 | 24 | 272360 | 1423 | 79470581 |
Ex-drug abuser | 18.73 | 9.51 | 4 | 272380 | 0 | 79472004 |
Umbilical hernia | 18.71 | 9.51 | 53 | 272331 | 5792 | 79466212 |
Insomnia | 18.66 | 9.51 | 1020 | 271364 | 244150 | 79227854 |
Abdominal pain upper | 18.61 | 9.51 | 939 | 271445 | 222880 | 79249124 |
Nasopharyngitis | 18.41 | 9.51 | 695 | 271689 | 253186 | 79218818 |
Renal tubular necrosis | 18.38 | 9.51 | 36 | 272348 | 25003 | 79447001 |
Bone lesion | 18.30 | 9.51 | 53 | 272331 | 5866 | 79466138 |
Anaemia | 18.29 | 9.51 | 1291 | 271093 | 443724 | 79028280 |
Caesarean section | 18.28 | 9.51 | 10 | 272374 | 12525 | 79459479 |
Puncture site haematoma | 18.25 | 9.51 | 10 | 272374 | 175 | 79471829 |
Hepatotoxicity | 18.12 | 9.51 | 102 | 272282 | 51250 | 79420754 |
Drug tolerance decreased | 18 | 9.51 | 11 | 272373 | 12967 | 79459037 |
Therapeutic response decreased | 17.97 | 9.51 | 144 | 272240 | 66709 | 79405295 |
Product substitution | 17.96 | 9.51 | 8 | 272376 | 87 | 79471917 |
Panniculitis | 17.85 | 9.51 | 10 | 272374 | 12361 | 79459643 |
Erythema | 17.84 | 9.51 | 604 | 271780 | 222686 | 79249318 |
Hyperreflexia | 17.74 | 9.51 | 66 | 272318 | 8319 | 79463685 |
Sepsis | 17.71 | 9.51 | 746 | 271638 | 268682 | 79203322 |
Pregnancy | 17.71 | 9.51 | 41 | 272343 | 26810 | 79445194 |
Premenstrual syndrome | 17.67 | 9.51 | 15 | 272369 | 551 | 79471453 |
Lymphopenia | 17.58 | 9.51 | 50 | 272334 | 30507 | 79441497 |
Muscle disorder | 17.54 | 9.51 | 51 | 272333 | 5656 | 79466348 |
Progressive multifocal leukoencephalopathy | 17.51 | 9.51 | 27 | 272357 | 20573 | 79451431 |
Tonic convulsion | 17.48 | 9.51 | 29 | 272355 | 2191 | 79469813 |
Bronchiectasis | 17.48 | 9.51 | 31 | 272353 | 22355 | 79449649 |
Post stroke epilepsy | 17.34 | 9.51 | 5 | 272379 | 12 | 79471992 |
Back pain | 17.32 | 9.51 | 1234 | 271150 | 302946 | 79169058 |
Feeling drunk | 17.32 | 9.51 | 45 | 272339 | 4674 | 79467330 |
Quality of life decreased | 17.25 | 9.51 | 76 | 272308 | 10344 | 79461660 |
Blood pressure systolic increased | 17.23 | 9.51 | 146 | 272238 | 66840 | 79405164 |
Aggression | 17.22 | 9.51 | 257 | 272127 | 50701 | 79421303 |
Blood pressure fluctuation | 16.97 | 9.51 | 147 | 272237 | 66998 | 79405006 |
Vasoplegia syndrome | 16.96 | 9.51 | 38 | 272346 | 3592 | 79468412 |
Therapy non-responder | 16.87 | 9.51 | 218 | 272166 | 92087 | 79379917 |
Mood swings | 16.81 | 9.51 | 121 | 272263 | 19759 | 79452245 |
Pleural mesothelioma | 16.78 | 9.51 | 7 | 272377 | 64 | 79471940 |
Accidental exposure to product | 16.76 | 9.51 | 53 | 272331 | 31269 | 79440735 |
Tenosynovitis | 16.76 | 9.51 | 17 | 272367 | 15537 | 79456467 |
Incorrect route of product administration | 16.73 | 9.51 | 62 | 272322 | 34867 | 79437137 |
Disinhibition | 16.65 | 9.51 | 31 | 272353 | 2567 | 79469437 |
Hanging | 16.60 | 9.51 | 9 | 272375 | 154 | 79471850 |
Mania | 16.53 | 9.51 | 113 | 272271 | 18147 | 79453857 |
Cardiac disorder | 16.50 | 9.51 | 316 | 272068 | 65441 | 79406563 |
Cushingoid | 16.47 | 9.51 | 6 | 272378 | 9546 | 79462458 |
Foot operation | 16.45 | 9.51 | 50 | 272334 | 5683 | 79466321 |
Allodynia | 16.43 | 9.51 | 24 | 272360 | 1624 | 79470380 |
Bronchopulmonary aspergillosis | 16.41 | 9.51 | 32 | 272352 | 22262 | 79449742 |
Myelodysplastic syndrome | 16.41 | 9.51 | 51 | 272333 | 30250 | 79441754 |
Snoring | 16.41 | 9.51 | 49 | 272335 | 5517 | 79466487 |
Pseudoporphyria | 16.32 | 9.51 | 15 | 272369 | 613 | 79471391 |
Adverse reaction | 16.24 | 9.51 | 69 | 272315 | 9245 | 79462759 |
Thymus disorder | 16.23 | 9.51 | 11 | 272373 | 286 | 79471718 |
Oedematous pancreatitis | 16.23 | 9.51 | 20 | 272364 | 1148 | 79470856 |
Anal haemorrhage | 16.19 | 9.51 | 41 | 272343 | 4193 | 79467811 |
Fear of disease | 16.17 | 9.51 | 21 | 272363 | 1271 | 79470733 |
Multiple-drug resistance | 16.11 | 9.51 | 5 | 272379 | 8803 | 79463201 |
BK virus infection | 16.10 | 9.51 | 5 | 272379 | 8799 | 79463205 |
Cardiac failure | 16.10 | 9.51 | 404 | 271980 | 154438 | 79317566 |
Device ineffective | 15.81 | 9.51 | 9 | 272375 | 170 | 79471834 |
Pancytopenia | 15.77 | 9.51 | 438 | 271946 | 165307 | 79306697 |
Secondary adrenocortical insufficiency | 15.74 | 9.51 | 33 | 272351 | 2981 | 79469023 |
Aspartate aminotransferase increased | 15.72 | 9.51 | 357 | 272027 | 138284 | 79333720 |
Dyspnoea | 15.70 | 9.51 | 2631 | 269753 | 854394 | 78617610 |
Thermal burn | 15.69 | 9.51 | 57 | 272327 | 7103 | 79464901 |
Hypothermia | 15.66 | 9.51 | 132 | 272252 | 22614 | 79449390 |
Vaccination site reaction | 15.63 | 9.51 | 8 | 272376 | 121 | 79471883 |
Lung neoplasm malignant | 15.61 | 9.51 | 46 | 272338 | 27746 | 79444258 |
Drug level below therapeutic | 15.44 | 9.51 | 7 | 272377 | 9763 | 79462241 |
Faecal disimpaction | 15.44 | 9.51 | 5 | 272379 | 20 | 79471984 |
Fluid retention | 15.43 | 9.51 | 158 | 272226 | 69651 | 79402353 |
Back injury | 15.38 | 9.51 | 74 | 272310 | 10449 | 79461555 |
Polymenorrhoea | 15.30 | 9.51 | 18 | 272366 | 984 | 79471020 |
Swollen tongue | 15.30 | 9.51 | 217 | 272167 | 42353 | 79429651 |
Performance enhancing product use | 15.26 | 9.51 | 7 | 272377 | 82 | 79471922 |
Product label confusion | 15.24 | 9.51 | 23 | 272361 | 1603 | 79470401 |
Surgery | 15.15 | 9.51 | 175 | 272209 | 32591 | 79439413 |
Trigger finger | 15.09 | 9.51 | 40 | 272344 | 4205 | 79467799 |
Musculoskeletal disorder | 15.05 | 9.51 | 125 | 272259 | 21323 | 79450681 |
Subileus | 15.02 | 9.51 | 48 | 272336 | 5606 | 79466398 |
Urticaria | 15.02 | 9.51 | 500 | 271884 | 184701 | 79287303 |
Immunosuppressant drug level increased | 15.01 | 9.51 | 6 | 272378 | 9021 | 79462983 |
Lip pruritus | 14.96 | 9.51 | 17 | 272367 | 895 | 79471109 |
Pharyngitis | 14.96 | 9.51 | 129 | 272255 | 22246 | 79449758 |
Ventricular tachycardia | 14.95 | 9.51 | 83 | 272301 | 41852 | 79430152 |
Postmortem blood drug level increased | 14.86 | 9.51 | 16 | 272368 | 793 | 79471211 |
Spinal operation | 14.86 | 9.51 | 60 | 272324 | 7857 | 79464147 |
Acidosis | 14.86 | 9.51 | 117 | 272267 | 19645 | 79452359 |
Enterococcal infection | 14.83 | 9.51 | 19 | 272365 | 15641 | 79456363 |
Labelled drug-drug interaction issue | 14.71 | 9.51 | 21 | 272363 | 1392 | 79470612 |
Mixed liver injury | 14.68 | 9.51 | 58 | 272326 | 7520 | 79464484 |
Blood glucose increased | 14.51 | 9.51 | 291 | 272093 | 114684 | 79357320 |
Magnesium deficiency | 14.48 | 9.51 | 14 | 272370 | 610 | 79471394 |
Respiratory rate decreased | 14.37 | 9.51 | 45 | 272339 | 5198 | 79466806 |
Visceral pain | 14.35 | 9.51 | 7 | 272377 | 95 | 79471909 |
Polyneuropathy in malignant disease | 14.17 | 9.51 | 10 | 272374 | 278 | 79471726 |
Breast cancer stage II | 14.17 | 9.51 | 5 | 272379 | 8115 | 79463889 |
Inflammation | 14.13 | 9.51 | 230 | 272154 | 93523 | 79378481 |
Fear of injection | 14.12 | 9.51 | 4 | 272380 | 7470 | 79464534 |
Gallbladder cholesterolosis | 14.07 | 9.51 | 14 | 272370 | 632 | 79471372 |
Ligament calcification | 14.06 | 9.51 | 9 | 272375 | 212 | 79471792 |
Hepatitis | 14.05 | 9.51 | 268 | 272116 | 55459 | 79416545 |
Electrocution | 14.05 | 9.51 | 3 | 272381 | 0 | 79472004 |
Vascular purpura | 13.99 | 9.51 | 32 | 272352 | 3066 | 79468938 |
Rectal prolapse | 13.97 | 9.51 | 26 | 272358 | 2152 | 79469852 |
Injection site pain | 13.97 | 9.51 | 337 | 272047 | 129501 | 79342503 |
Abdominal pain lower | 13.93 | 9.51 | 168 | 272216 | 31614 | 79440390 |
Foaming at mouth | 13.91 | 9.51 | 24 | 272360 | 1873 | 79470131 |
Cystitis haemorrhagic | 13.84 | 9.51 | 7 | 272377 | 9165 | 79462839 |
Gallbladder polyp | 13.84 | 9.51 | 17 | 272367 | 973 | 79471031 |
Oral discomfort | 13.81 | 9.51 | 68 | 272316 | 9692 | 79462312 |
Product administration error | 13.81 | 9.51 | 168 | 272216 | 31678 | 79440326 |
Blood bilirubin increased | 13.79 | 9.51 | 152 | 272232 | 66080 | 79405924 |
Lichen sclerosus | 13.78 | 9.51 | 17 | 272367 | 977 | 79471027 |
Hypoaesthesia oral | 13.75 | 9.51 | 89 | 272295 | 14035 | 79457969 |
Tinnitus | 13.61 | 9.51 | 220 | 272164 | 44113 | 79427891 |
Growth disorder | 13.52 | 9.51 | 5 | 272379 | 32 | 79471972 |
Mucormycosis | 13.49 | 9.51 | 6 | 272378 | 8463 | 79463541 |
Arthrofibrosis | 13.39 | 9.51 | 7 | 272377 | 111 | 79471893 |
Product used for unknown indication | 13.29 | 9.51 | 21 | 272363 | 1523 | 79470481 |
Anterograde amnesia | 13.29 | 9.51 | 14 | 272370 | 677 | 79471327 |
Wrong rate | 13.26 | 9.51 | 6 | 272378 | 68 | 79471936 |
Autoimmune haemolytic anaemia | 13.25 | 9.51 | 6 | 272378 | 8374 | 79463630 |
Feeling abnormal | 13.25 | 9.51 | 668 | 271716 | 158531 | 79313473 |
Hyperthermia | 13.13 | 9.51 | 106 | 272278 | 17931 | 79454073 |
Vasculitis | 13.07 | 9.51 | 43 | 272341 | 25059 | 79446945 |
Hepatic cirrhosis | 13.05 | 9.51 | 68 | 272316 | 34838 | 79437166 |
Lumbar radiculopathy | 13.00 | 9.51 | 24 | 272360 | 1975 | 79470029 |
Second primary malignancy | 12.99 | 9.51 | 18 | 272366 | 14332 | 79457672 |
Pulmonary alveolar haemorrhage | 12.95 | 9.51 | 12 | 272372 | 11445 | 79460559 |
Aplastic anaemia | 12.92 | 9.51 | 26 | 272358 | 17879 | 79454125 |
Lymphoma | 12.91 | 9.51 | 25 | 272359 | 17435 | 79454569 |
Therapy partial responder | 12.78 | 9.51 | 25 | 272359 | 17372 | 79454632 |
Blood pressure decreased | 12.77 | 9.51 | 251 | 272133 | 99215 | 79372789 |
Sinus congestion | 12.63 | 9.51 | 31 | 272353 | 19865 | 79452139 |
Back disorder | 12.55 | 9.51 | 75 | 272309 | 11503 | 79460501 |
Oesophagitis chemical | 12.53 | 9.51 | 6 | 272378 | 78 | 79471926 |
Manipulation | 12.53 | 9.51 | 6 | 272378 | 78 | 79471926 |
Pneumonia viral | 12.37 | 9.51 | 8 | 272376 | 9150 | 79462854 |
Purple glove syndrome | 12.37 | 9.51 | 9 | 272375 | 263 | 79471741 |
Withdrawal catatonia | 12.19 | 9.51 | 8 | 272376 | 197 | 79471807 |
Hypopnoea | 12.17 | 9.51 | 43 | 272341 | 5286 | 79466718 |
Anoxia | 12.16 | 9.51 | 10 | 272374 | 351 | 79471653 |
Prothrombin level increased | 12.12 | 9.51 | 11 | 272373 | 442 | 79471562 |
Spleen congestion | 12.10 | 9.51 | 11 | 272373 | 443 | 79471561 |
Femoral artery aneurysm | 12.08 | 9.51 | 8 | 272376 | 200 | 79471804 |
Ulcer | 12 | 9.51 | 57 | 272327 | 29915 | 79442089 |
Thecal sac compression | 11.98 | 9.51 | 3 | 272381 | 3 | 79472001 |
Coagulopathy | 11.91 | 9.51 | 73 | 272311 | 35933 | 79436071 |
Diabetes mellitus | 11.91 | 9.51 | 192 | 272192 | 78198 | 79393806 |
Hypokalaemia | 11.90 | 9.51 | 604 | 271780 | 143436 | 79328568 |
Pulmonary toxicity | 11.89 | 9.51 | 16 | 272368 | 12898 | 79459106 |
Ill-defined disorder | 11.88 | 9.51 | 156 | 272228 | 65719 | 79406285 |
Sinusitis | 11.88 | 9.51 | 546 | 271838 | 194955 | 79277049 |
Pulmonary fibrosis | 11.86 | 9.51 | 95 | 272289 | 44017 | 79427987 |
Lip erosion | 11.78 | 9.51 | 20 | 272364 | 1540 | 79470464 |
Narcolepsy | 11.78 | 9.51 | 18 | 272366 | 1268 | 79470736 |
Hypersensitivity vasculitis | 11.77 | 9.51 | 51 | 272333 | 6892 | 79465112 |
Infective pulmonary exacerbation of cystic fibrosis | 11.75 | 9.51 | 16 | 272368 | 12835 | 79459169 |
Poor venous access | 11.74 | 9.51 | 28 | 272356 | 18121 | 79453883 |
Organising pneumonia | 11.74 | 9.51 | 12 | 272372 | 10927 | 79461077 |
Appetite disorder | 11.73 | 9.51 | 55 | 272329 | 7684 | 79464320 |
Haemorrhage | 11.68 | 9.51 | 230 | 272154 | 90888 | 79381116 |
Carcinoembryonic antigen | 11.65 | 9.51 | 6 | 272378 | 92 | 79471912 |
Myasthenia gravis | 11.63 | 9.51 | 11 | 272373 | 10388 | 79461616 |
Skin toxicity | 11.60 | 9.51 | 7 | 272377 | 8307 | 79463697 |
Lymphadenopathy | 11.57 | 9.51 | 121 | 272263 | 53126 | 79418878 |
Logorrhoea | 11.54 | 9.51 | 37 | 272347 | 4328 | 79467676 |
Neuroglycopenia | 11.50 | 9.51 | 11 | 272373 | 473 | 79471531 |
Carbohydrate antigen 15-3 | 11.48 | 9.51 | 6 | 272378 | 95 | 79471909 |
Hypoventilation | 11.44 | 9.51 | 52 | 272332 | 7172 | 79464832 |
Optic nerve operation | 11.39 | 9.51 | 11 | 272373 | 479 | 79471525 |
Compulsive shopping | 11.38 | 9.51 | 14 | 272370 | 802 | 79471202 |
Product dispensing error | 11.37 | 9.51 | 81 | 272303 | 13182 | 79458822 |
Feeling jittery | 11.35 | 9.51 | 79 | 272305 | 12762 | 79459242 |
Haematuria | 11.34 | 9.51 | 166 | 272218 | 68670 | 79403334 |
Temperature regulation disorder | 11.30 | 9.51 | 3 | 272381 | 5850 | 79466154 |
Visual acuity reduced | 11.25 | 9.51 | 57 | 272327 | 29412 | 79442592 |
Respiratory rate increased | 11.25 | 9.51 | 37 | 272347 | 21563 | 79450441 |
Tongue disorder | 11.23 | 9.51 | 19 | 272365 | 13956 | 79458048 |
Disseminated intravascular coagulation | 11.18 | 9.51 | 74 | 272310 | 35768 | 79436236 |
Drooling | 11.16 | 9.51 | 45 | 272339 | 5889 | 79466115 |
Gastric cancer | 11.11 | 9.51 | 11 | 272373 | 10168 | 79461836 |
Electrocardiogram QT interval | 11.08 | 9.51 | 8 | 272376 | 231 | 79471773 |
Livedo reticularis | 11.05 | 9.51 | 35 | 272349 | 4068 | 79467936 |
Scrotal infection | 11.05 | 9.51 | 12 | 272372 | 601 | 79471403 |
Middle insomnia | 11.04 | 9.51 | 24 | 272360 | 16045 | 79455959 |
Post cardiac arrest syndrome | 11.03 | 9.51 | 4 | 272380 | 24 | 79471980 |
Prothrombin time prolonged | 10.99 | 9.51 | 26 | 272358 | 16873 | 79455131 |
Complications of transplanted kidney | 10.97 | 9.51 | 4 | 272380 | 6362 | 79465642 |
Immune reconstitution inflammatory syndrome | 10.96 | 9.51 | 19 | 272365 | 13822 | 79458182 |
Flushing | 10.96 | 9.51 | 224 | 272160 | 88044 | 79383960 |
Rotator cuff syndrome | 10.90 | 9.51 | 84 | 272300 | 14011 | 79457993 |
Drug dependence, antepartum | 10.89 | 9.51 | 4 | 272380 | 25 | 79471979 |
Depressed mood | 10.84 | 9.51 | 229 | 272155 | 48251 | 79423753 |
Resting tremor | 10.83 | 9.51 | 19 | 272365 | 1502 | 79470502 |
Bladder dilatation | 10.83 | 9.51 | 23 | 272361 | 2096 | 79469908 |
Electric shock sensation | 10.81 | 9.51 | 14 | 272370 | 845 | 79471159 |
Cell death | 10.80 | 9.51 | 38 | 272346 | 4661 | 79467343 |
Peritoneal perforation | 10.79 | 9.51 | 7 | 272377 | 169 | 79471835 |
Syringe issue | 10.78 | 9.51 | 4 | 272380 | 6294 | 79465710 |
Alcoholic seizure | 10.77 | 9.51 | 3 | 272381 | 6 | 79471998 |
Oropharyngeal neoplasm | 10.77 | 9.51 | 3 | 272381 | 6 | 79471998 |
Subarachnoid haemorrhage | 10.72 | 9.51 | 45 | 272339 | 24420 | 79447584 |
Haemolysis | 10.69 | 9.51 | 17 | 272367 | 12795 | 79459209 |
Decreased immune responsiveness | 10.68 | 9.51 | 42 | 272342 | 5433 | 79466571 |
Theft | 10.67 | 9.51 | 8 | 272376 | 245 | 79471759 |
Lymphoproliferative disorder | 10.61 | 9.51 | 3 | 272381 | 5612 | 79466392 |
Papilloedema | 10.60 | 9.51 | 4 | 272380 | 6229 | 79465775 |
Retinal toxicity | 10.54 | 9.51 | 18 | 272366 | 1393 | 79470611 |
No adverse event | 10.51 | 9.51 | 79 | 272305 | 37113 | 79434891 |
Dehydration | 10.51 | 9.51 | 718 | 271666 | 247469 | 79224535 |
Diastolic hypotension | 10.50 | 9.51 | 7 | 272377 | 177 | 79471827 |
Methaemoglobinaemia | 10.45 | 9.51 | 3 | 272381 | 5554 | 79466450 |
Hypoosmolar state | 10.43 | 9.51 | 9 | 272375 | 338 | 79471666 |
Renal cancer | 10.41 | 9.51 | 16 | 272368 | 12210 | 79459794 |
Menstruation delayed | 10.40 | 9.51 | 18 | 272366 | 1408 | 79470596 |
Blood phosphorus increased | 10.38 | 9.51 | 12 | 272372 | 10335 | 79461669 |
Drug level decreased | 10.32 | 9.51 | 21 | 272363 | 14381 | 79457623 |
Pre-existing condition improved | 10.32 | 9.51 | 42 | 272342 | 5521 | 79466483 |
Injection site swelling | 10.28 | 9.51 | 107 | 272277 | 47025 | 79424979 |
Basal cell carcinoma | 10.28 | 9.51 | 80 | 272304 | 37295 | 79434709 |
Central-alveolar hypoventilation | 10.27 | 9.51 | 4 | 272380 | 30 | 79471974 |
Burning mouth syndrome | 10.27 | 9.51 | 11 | 272373 | 542 | 79471462 |
Oral lichenoid reaction | 10.20 | 9.51 | 6 | 272378 | 121 | 79471883 |
Gastritis | 10.19 | 9.51 | 225 | 272159 | 47768 | 79424236 |
Acquired cystic kidney disease | 10.18 | 9.51 | 5 | 272379 | 69 | 79471935 |
Dermo-hypodermitis | 10.16 | 9.51 | 13 | 272371 | 775 | 79471229 |
Haemorrhagic fever | 10.16 | 9.51 | 4 | 272380 | 31 | 79471973 |
Injection site erythema | 10.14 | 9.51 | 197 | 272187 | 78000 | 79394004 |
Orthostatic hypotension | 10.13 | 9.51 | 133 | 272251 | 56031 | 79415973 |
Metastases to liver | 10.12 | 9.51 | 56 | 272328 | 28258 | 79443746 |
Hip arthroplasty | 10.08 | 9.51 | 76 | 272308 | 35680 | 79436324 |
Enthesopathy | 10.07 | 9.51 | 15 | 272369 | 11593 | 79460411 |
Unintentional medical device removal | 10.07 | 9.51 | 7 | 272377 | 7705 | 79464299 |
Body temperature increased | 10.04 | 9.51 | 100 | 272284 | 44320 | 79427684 |
Hot flush | 10.03 | 9.51 | 252 | 272132 | 54625 | 79417379 |
Retinal haemorrhage | 10.03 | 9.51 | 8 | 272376 | 8209 | 79463795 |
Dermatitis bullous | 10.01 | 9.51 | 21 | 272363 | 14224 | 79457780 |
Activated partial thromboplastin time prolonged | 9.98 | 9.51 | 21 | 272363 | 14207 | 79457797 |
Pleural neoplasm | 9.97 | 9.51 | 9 | 272375 | 359 | 79471645 |
Discoloured vomit | 9.93 | 9.51 | 18 | 272366 | 1460 | 79470544 |
Perineal infection | 9.92 | 9.51 | 13 | 272371 | 794 | 79471210 |
Carotid pulse abnormal | 9.92 | 9.51 | 3 | 272381 | 9 | 79471995 |
Mouth swelling | 9.92 | 9.51 | 44 | 272340 | 6007 | 79465997 |
Chemical poisoning | 9.91 | 9.51 | 7 | 272377 | 195 | 79471809 |
Cystitis noninfective | 9.88 | 9.51 | 17 | 272367 | 1323 | 79470681 |
Sweat gland disorder | 9.88 | 9.51 | 7 | 272377 | 196 | 79471808 |
Rheumatic fever | 9.88 | 9.51 | 57 | 272327 | 28468 | 79443536 |
Liver disorder | 9.83 | 9.51 | 181 | 272203 | 72236 | 79399768 |
Dysphonia | 9.77 | 9.51 | 259 | 272125 | 56613 | 79415391 |
Breast cancer female | 9.76 | 9.51 | 15 | 272369 | 11446 | 79460558 |
Hyperinsulinaemia | 9.76 | 9.51 | 7 | 272377 | 200 | 79471804 |
Postictal paralysis | 9.73 | 9.51 | 9 | 272375 | 371 | 79471633 |
Prostate cancer | 9.72 | 9.51 | 70 | 272314 | 33198 | 79438806 |
Granulocytopenia | 9.70 | 9.51 | 15 | 272369 | 11416 | 79460588 |
Rheumatoid arthritis | 9.69 | 9.51 | 598 | 271786 | 207872 | 79264132 |
Accidental poisoning | 9.67 | 9.51 | 19 | 272365 | 1638 | 79470366 |
Incontinence | 9.65 | 9.51 | 82 | 272302 | 14082 | 79457922 |
Respiratory depth decreased | 9.64 | 9.51 | 4 | 272380 | 36 | 79471968 |
Capillary fragility | 9.64 | 9.51 | 7 | 272377 | 204 | 79471800 |
Hyperbilirubinaemia | 9.60 | 9.51 | 47 | 272337 | 24471 | 79447533 |
Endophthalmitis | 9.56 | 9.51 | 5 | 272379 | 6423 | 79465581 |
Alcohol abuse | 9.56 | 9.51 | 40 | 272344 | 5323 | 79466681 |
Limb fracture | 9.55 | 9.51 | 4 | 272380 | 37 | 79471967 |
Wrong product administered | 9.53 | 9.51 | 58 | 272326 | 8954 | 79463050 |
None
Source | Code | Description |
---|---|---|
ATC | N02AJ13 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
ATC | N02AJ14 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
ATC | N02AJ15 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
ATC | N02AJ16 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
ATC | N02AX02 | NERVOUS SYSTEM ANALGESICS OPIOIDS Other opioids |
CHEBI has role | CHEBI:35482 | narcotic analgesic |
CHEBI has role | CHEBI:35640 | adrenergic uptake inhibitors |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:48279 | serotonin antagonists |
CHEBI has role | CHEBI:48876 | muscarinic antagonists |
CHEBI has role | CHEBI:48878 | nicotinic antagonists |
CHEBI has role | CHEBI:50949 | SSRI |
CHEBI has role | CHEBI:51177 | anti-tussive |
CHEBI has role | CHEBI:55322 | mu-opioid agonists |
CHEBI has role | CHEBI:59282 | kappa-opioid receptor agonists |
CHEBI has role | CHEBI:60643 | N-methyl-D-aspartate receptor antagonists |
CHEBI has role | CHEBI:70774 | vanilloid receptor 1 antagonists |
CHEBI has role | CHEBI:78298 | environmental contaminants |
FDA MoA | N0000175684 | Full Opioid Agonists |
FDA EPC | N0000175690 | Opioid Agonist |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000701 | Analgesics, Opioid |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009294 | Narcotics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pain | indication | 22253000 | |
Chronic pain | indication | 82423001 | |
Osteoarthritis | indication | 396275006 | |
Fibromyalgia | off-label use | 203082005 | DOID:631 |
Neuropathic pain | off-label use | 247398009 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Lowered convulsive threshold | contraindication | 19260006 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Poisoning by acetaminophen | contraindication | 70273001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Infectious disease of central nervous system | contraindication | 128117002 | |
Seizure disorder | contraindication | 128613002 | |
Alcohol withdrawal syndrome | contraindication | 191480000 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Poisoning by opiate analgesic drug | contraindication | 241749009 | |
Suicidal | contraindication | 267073005 | |
Pregnancy, function | contraindication | 289908002 | |
Drug withdrawal | contraindication | 363101005 | |
Serotonin syndrome | contraindication | 371089000 | |
Central nervous system depression | contraindication | 418072004 | |
Benzodiazepine Toxicity | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.01 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
56MG;44MG | SEGLENTIS | KOWA PHARMS | N213426 | Oct. 15, 2021 | RX | TABLET | ORAL | 10238668 | April 19, 2030 | A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB |
56MG;44MG | SEGLENTIS | KOWA PHARMS | N213426 | Oct. 15, 2021 | RX | TABLET | ORAL | 10548909 | April 19, 2030 | A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB |
56MG;44MG | SEGLENTIS | KOWA PHARMS | N213426 | Oct. 15, 2021 | RX | TABLET | ORAL | 11478488 | April 19, 2030 | A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB |
5MG/ML | QDOLO | ATHENA | N214044 | Sept. 1, 2020 | RX | SOLUTION | ORAL | 11103452 | Sept. 1, 2040 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE AN OPIOID ANALGESIC AND FOR WHICH ALTERNATIVE TREATMENTS ARE INADEQUATE |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
56MG;44MG | SEGLENTIS | KOWA PHARMS | N213426 | Oct. 15, 2021 | RX | TABLET | ORAL | Oct. 15, 2024 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | Ki | 5.80 | CHEMBL | CHEMBL | |||
Sodium-dependent serotonin transporter | Transporter | IC50 | 5.83 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | IC50 | 6.10 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 7.85 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 8.03 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.28 | WOMBAT-PK | |||||
Mu-type opioid receptor | GPCR | Ki | 5.62 | CHEMBL |
ID | Source |
---|---|
4023985 | VUID |
N0000021990 | NUI |
D01355 | KEGG_DRUG |
36282-47-0 | SECONDARY_CAS_RN |
4020912 | VANDF |
4023985 | VANDF |
C0040610 | UMLSCUI |
CHEBI:9648 | CHEBI |
CHEMBL1237044 | ChEMBL_ID |
DB00193 | DRUGBANK_ID |
CHEMBL1237065 | ChEMBL_ID |
D014147 | MESH_DESCRIPTOR_UI |
33741 | PUBCHEM_CID |
8286 | IUPHAR_LIGAND_ID |
2722 | INN_ID |
39J1LGJ30J | UNII |
10689 | RXNORM |
44050 | MMSL |
5605 | MMSL |
d03826 | MMSL |
004180 | NDDF |
004181 | NDDF |
108505002 | SNOMEDCT_US |
108507005 | SNOMEDCT_US |
386858008 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0058 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 29 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0058 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 29 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4151 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 37 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4152 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 35 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4153 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 35 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4154 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | ANDA | 35 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7810 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 28 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8005 | TABLET, COATED | 50 mg | ORAL | ANDA | 14 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8005 | TABLET, COATED | 50 mg | ORAL | ANDA | 14 sections |
TRAMADOL HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6365 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
tramadol hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7179 | TABLET | 50 mg | ORAL | ANDA | 33 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-009 | TABLET | 50 mg | ORAL | ANDA | 17 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-531 | TABLET | 50 mg | ORAL | ANDA | 16 sections |
TRAMADOL HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-786 | TABLET | 50 mg | ORAL | ANDA | 16 sections |
Tramadol HydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-689 | CAPSULE | 100 mg | ORAL | NDA AUTHORIZED GENERIC | 38 sections |
Tramadol HydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-689 | CAPSULE | 100 mg | ORAL | NDA AUTHORIZED GENERIC | 38 sections |
Tramadol HydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-690 | CAPSULE | 200 mg | ORAL | NDA AUTHORIZED GENERIC | 38 sections |
Tramadol HydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-690 | CAPSULE | 200 mg | ORAL | NDA AUTHORIZED GENERIC | 38 sections |
Tramadol HydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-691 | CAPSULE | 300 mg | ORAL | NDA AUTHORIZED GENERIC | 38 sections |
Tramadol HydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-691 | CAPSULE | 300 mg | ORAL | NDA AUTHORIZED GENERIC | 38 sections |
Tramadol Hydrochloride | Human Prescription Drug Label | 1 | 16571-716 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
Tramadol Hydrochloride | Human Prescription Drug Label | 1 | 16571-716 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
TRAMADOL HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-229 | TABLET | 50 mg | ORAL | ANDA | 28 sections |
Tramadol Hydrochloride and Acetaminophen | HUMAN PRESCRIPTION DRUG LABEL | 2 | 16590-230 | TABLET, COATED | 37.50 mg | ORAL | NDA | 31 sections |
RYZOLT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-244 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | NDA | 12 sections |
RYZOLT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-253 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA | 12 sections |
RYZOLT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-255 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | NDA | 12 sections |
Tramadol ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-893 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 13 sections |
Tramadol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-132 | TABLET | 50 mg | ORAL | ANDA | 16 sections |
ULTRACET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-143 | TABLET | 37.50 mg | ORAL | NDA | 25 sections |