tramadol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
analgesics 2711 27203-92-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tramadol
  • (+/-)-Tramadol
  • racemic tramadol
  • tradolan
  • tramadon
  • tramadol hydrochloride
  • tramadol HCl
  • twotram
A narcotic analgesic proposed for severe pain. It may be habituating.
  • Molecular weight: 263.38
  • Formula: C16H25NO2
  • CLOGP: 3.10
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.70
  • ALOGS: -2.55
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P
0.30 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 16.27 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 72.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.80 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.80 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.80 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.335 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.107 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 19.055 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 4.932 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 83.430 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 81.190 % High 1
herg hERG pIC50 4.677 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.202 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.648 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 85.600 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,SIK3,TEK,TGFBR1,ZAP70 34
kinase-selectivity-class AXL,EIF2AK3,EPHB4,ERBB2,PDK4,SIK2 6
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.938 High 1
mh-clint Mouse hepatocyte intrinsic clearance 32.359 High 1
mppb Mouse plasma protein binding (% unbound) 81.880 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 4.457 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 82.390 % High 1
rh-clint Rat hepatocyte intrinsic clearance 38.905 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 88.590 % High 1
rppb Rat plasma protein binding (% unbound) 81.810 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 931.108 uM High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 25, 2020 PMDA NIPPON ZOKI PHARMACEUTICAL CO., LTD.
March 3, 1995 FDA JANSSEN PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug dependence 757.52 9.36 719 330355 28608 90268765
Serotonin syndrome 716.41 9.36 785 330289 37102 90260271
Drug abuse 664.72 9.36 1128 329946 81219 90216154
Poisoning deliberate 663.69 9.36 521 330553 15965 90281408
Drug use disorder 645.06 9.36 394 330680 7949 90289424
Drug hypersensitivity 549.31 9.36 3225 327849 460384 89836989
Toxicity to various agents 511.43 9.36 2245 328829 285601 90011772
Completed suicide 474.73 9.36 1383 329691 143675 90153698
Coma 343.16 9.36 795 330279 71837 90225536
Drug ineffective 318.28 9.36 3383 327691 1380915 88916458
Wheezing 308.10 9.36 1697 329377 236383 90060990
Intentional overdose 281.65 9.36 868 330206 92966 90204407
Vomiting 257.22 9.36 4173 326901 784120 89513253
Prescription form tampering 251.08 9.36 96 330978 631 90296742
Deafness transitory 248.97 9.36 130 330944 1913 90295460
Withdrawal syndrome 247.86 9.36 356 330718 22168 90275205
Bradypnoea 240.64 9.36 171 330903 4487 90292886
Off label use 212.76 9.36 2797 328277 1099455 89197918
Nasal oedema 190.46 9.36 172 330902 6412 90290961
Lip dry 188.57 9.36 800 330274 100155 90197218
Gastrointestinal pain 180.93 9.36 214 330860 10992 90286381
Joint range of motion decreased 173.38 9.36 964 330110 134679 90162694
Sensitisation 172.48 9.36 134 330940 4041 90293332
Somnolence 170.27 9.36 1327 329747 207757 90089616
Miosis 168.03 9.36 190 330884 9294 90288079
Overdose 154.90 9.36 1047 330027 156662 90140711
Polycystic ovaries 152.44 9.36 142 330932 5512 90291861
Oedema 148.31 9.36 1244 329830 199051 90098322
Drug withdrawal syndrome 144.05 9.36 322 330752 28401 90268972
Ejection fraction 142.91 9.36 105 330969 2906 90294467
Epilepsy 138.74 9.36 632 330442 81574 90215799
Blepharospasm 137.68 9.36 481 330593 54964 90242409
Respiratory depression 137.18 9.36 222 330852 15353 90282020
Nail disorder 136.08 9.36 500 330574 58567 90238806
Drug interaction 134.43 9.36 1573 329501 274880 90022493
Taste disorder 133.49 9.36 511 330563 61035 90236338
Facet joint syndrome 131.59 9.36 708 330366 97681 90199692
Fibromyalgia 129.55 9.36 1236 329838 205033 90092340
Onychomadesis 127.43 9.36 414 330660 45584 90251789
Dry mouth 127.26 9.36 1126 329948 182933 90114440
Mydriasis 124.16 9.36 208 330866 14804 90282569
Myelosuppression 123.56 9.36 23 331051 53568 90243805
Asthma 119.99 9.36 1383 329691 240777 90056596
Breast cancer stage III 118.63 9.36 616 330458 83831 90213542
Contraindicated product administered 116.31 9.36 689 330385 319450 89977923
Suicide attempt 115.78 9.36 564 330510 74835 90222538
Victim of chemical submission 107.49 9.36 53 331021 686 90296687
Hepatocellular injury 107.28 9.36 289 330785 28669 90268704
Pyrexia 106.33 9.36 1735 329339 658750 89638623
Device expulsion 102.25 9.36 14 331060 40872 90256501
Wound infection 96.55 9.36 693 330381 105709 90191664
Psoriatic arthropathy 96.21 9.36 1265 329809 227070 90070303
Back injury 96.15 9.36 381 330693 46241 90251132
Shoulder arthroplasty 94.21 9.36 95 330979 4071 90293302
Road traffic accident 93.66 9.36 694 330380 106932 90190441
Drug withdrawal maintenance therapy 93.34 9.36 22 331052 10 90297363
Peripheral venous disease 90.80 9.36 571 330503 83350 90214023
Febrile neutropenia 90.44 9.36 287 330787 158062 90139311
Memory impairment 90.41 9.36 1110 329964 196134 90101239
Onychomycosis 89.99 9.36 321 330753 37055 90260318
Product quality issue 89.13 9.36 545 330529 78780 90218593
Drug detoxification 88.39 9.36 37 331037 317 90297056
Substance use disorder 83.81 9.36 65 331009 1955 90295418
Neck pain 82.80 9.36 705 330369 113258 90184115
Inflammation 82.26 9.36 1006 330068 177586 90119787
Blood test abnormal 81.57 9.36 213 330861 20739 90276634
Gait inability 80.53 9.36 854 330220 145602 90151771
Alopecia 80.40 9.36 1298 329776 493773 89803600
Finger deformity 79.60 9.36 283 330791 32614 90264759
Neutropenia 79.55 9.36 488 330586 224416 90072957
Type 2 diabetes mellitus 79.45 9.36 1111 329963 202133 90095240
Adverse reaction 79.23 9.36 264 330810 29448 90267925
Disease progression 79.21 9.36 299 330775 156316 90141057
Maternal exposure during pregnancy 78.74 9.36 888 330186 359175 89938198
Gastrooesophageal reflux disease 77.92 9.36 940 330134 165397 90131976
Depersonalisation/derealisation disorder 77.65 9.36 57 331017 1575 90295798
Cardio-respiratory arrest 76.85 9.36 443 330631 62697 90234676
Poisoning 76.76 9.36 171 330903 15046 90282327
Abortion spontaneous 76.12 9.36 52 331022 54004 90243369
Sleep disorder 75.59 9.36 1078 329996 196952 90100421
Confusional state 75.58 9.36 1896 329178 384309 89913064
Intentional product misuse 75.25 9.36 573 330501 89031 90208342
Macular degeneration 74.40 9.36 23 331051 37947 90259426
Anaemia 74.07 9.36 878 330196 351924 89945449
Live birth 73.37 9.36 518 330556 78589 90218784
Discomfort 73.13 9.36 645 330429 273690 90023683
Liver function test increased 72.59 9.36 545 330529 84310 90213063
Lung disorder 71.95 9.36 851 330223 149032 90148341
Blood pressure increased 70.75 9.36 426 330648 196791 90100582
Pharyngitis 70.49 9.36 208 330866 21739 90275634
Sciatica 68.88 9.36 618 330456 100764 90196609
COVID-19 68.59 9.36 350 330724 168493 90128880
Erythema 68.38 9.36 523 330551 228723 90068650
Hypercholesterolaemia 68.03 9.36 614 330460 100278 90197095
Functional gastrointestinal disorder 67.78 9.36 88 330986 4974 90292399
Derealisation 66.48 9.36 50 331024 1435 90295938
Osteoarthritis 65.96 9.36 1043 330031 194687 90102686
Ejection fraction abnormal 64.16 9.36 61 331013 2430 90294943
Respiratory tract infection 63.30 9.36 401 330673 58677 90238696
Mobility decreased 63.17 9.36 1276 329798 249458 90047915
Rheumatic fever 63.08 9.36 845 330229 152276 90145097
Product label confusion 62.69 9.36 205 330869 22645 90274728
Asphyxia 62.22 9.36 101 330973 7002 90290371
C-reactive protein 61.22 9.36 252 330822 31115 90266258
Rash 60.90 9.36 2336 328738 793764 89503609
Drug diversion 60.08 9.36 41 331033 1006 90296367
Carpal tunnel syndrome 59.75 9.36 208 330866 23720 90273653
Myocardial infarction 58.46 9.36 195 330879 105777 90191596
Cholestasis 58.22 9.36 275 330799 36024 90261349
Injury 58.19 9.36 1029 330045 196320 90101053
Hypoaesthesia 57.76 9.36 1530 329544 312680 89984693
Hallucination 57.19 9.36 425 330649 65534 90231839
Night sweats 56.98 9.36 720 330354 128046 90169327
Drug resistance 56.93 9.36 20 331054 30429 90266944
Nephrectomy 55.83 9.36 51 331023 1930 90295443
Leukopenia 55.77 9.36 185 330889 100525 90196848
Swollen tongue 54.98 9.36 321 330753 45635 90251738
Abnormal loss of weight 53.08 9.36 92 330982 6731 90290642
Rhinitis allergic 52.88 9.36 158 330916 16627 90280746
Gastric pH decreased 52.79 9.36 37 331037 949 90296424
Depression 52.76 9.36 1455 329619 299146 89998227
Analgesic drug level increased 52.60 9.36 59 331015 2860 90294513
Red blood cell sedimentation rate abnormal 52.46 9.36 12 331062 24192 90273181
Respiratory acidosis 52.43 9.36 101 330973 8018 90289355
Prescription drug used without a prescription 52.28 9.36 62 331012 3193 90294180
Product use issue 52.17 9.36 869 330205 329050 89968323
Chest discomfort 51.13 9.36 296 330778 138069 90159304
Haemoglobin decreased 50.91 9.36 364 330710 161592 90135781
Treatment failure 50.55 9.36 793 330281 303135 89994238
Hepatitis 50 9.36 435 330639 70304 90227069
Mycotic allergy 49.89 9.36 37 331037 1039 90296334
Cardiac failure congestive 49.52 9.36 189 330885 98505 90198868
Multiple drug therapy 48.74 9.36 90 330984 6919 90290454
Platelet count decreased 46.96 9.36 300 330774 136669 90160704
Disease recurrence 46.94 9.36 41 331033 37612 90259761
Drug intolerance 46.70 9.36 1261 329813 446330 89851043
Injection site pain 45.99 9.36 409 330665 173290 90124083
C-reactive protein abnormal 45.97 9.36 687 330387 126742 90170631
Rheumatoid nodule 45.75 9.36 9 331065 20157 90277216
Wrong technique in product usage process 45.73 9.36 123 330951 71448 90225925
Thrombotic microangiopathy 45.66 9.36 3 331071 15740 90281633
Therapeutic product effect decreased 45.23 9.36 727 330347 276844 90020529
Hepatic function abnormal 44.91 9.36 62 331012 46226 90251147
Blood creatinine increased 44.75 9.36 204 330870 101182 90196191
Drug dependence, antepartum 44.55 9.36 15 331059 64 90297309
Fall 44.45 9.36 2169 328905 479641 89817732
Feeding disorder 44.40 9.36 153 330921 17359 90280014
Grip strength decreased 44.13 9.36 525 330549 92051 90205322
Clonus 44.04 9.36 77 330997 5673 90291700
Cytomegalovirus infection 44.02 9.36 21 331053 26581 90270792
Multiple organ dysfunction syndrome 44.00 9.36 117 330957 68219 90229154
Immunodeficiency 43.89 9.36 56 331018 43178 90254195
Exposure during pregnancy 43.81 9.36 610 330464 237800 90059573
Irritable bowel syndrome 43.70 9.36 1029 330045 206419 90090954
Sleep apnoea syndrome 42.79 9.36 229 330845 31518 90265855
Drug eruption 42.41 9.36 40 331034 35367 90262006
Physical deconditioning 41.69 9.36 46 331028 2189 90295184
Pancytopenia 40.41 9.36 265 330809 119998 90177375
Septic shock 40.41 9.36 164 330910 83996 90213377
Hallucination, visual 40.04 9.36 179 330895 22913 90274460
Abdominal pain upper 39.88 9.36 1539 329535 331135 89966238
Creatinine renal clearance decreased 39.72 9.36 10 331064 18889 90278484
Thrombocytopenia 39.44 9.36 531 330543 208194 90089179
Decorticate posture 39.34 9.36 21 331053 324 90297049
Obesity 38.90 9.36 571 330503 104936 90192437
Peripheral circulatory failure 38.90 9.36 38 331036 1566 90295807
H1N1 influenza 38.59 9.36 42 331032 1968 90295405
Acute generalised exanthematous pustulosis 38.55 9.36 124 330950 13579 90283794
Muscle spasms 38.12 9.36 1197 329877 250686 90046687
Foetal death 38.08 9.36 14 331060 20709 90276664
Skin necrosis 37.52 9.36 8 331066 16933 90280440
Hepatotoxicity 37.30 9.36 69 331005 45773 90251600
Dependence 37.16 9.36 42 331032 2053 90295320
Drug-induced liver injury 37.00 9.36 498 330576 89820 90207553
Bursitis 36.86 9.36 681 330393 130973 90166400
Premature baby 36.83 9.36 23 331051 25054 90272319
Therapeutic response decreased 36.43 9.36 186 330888 89543 90207830
Accidental exposure to product 36.06 9.36 62 331012 42304 90255069
Pemphigus 35.35 9.36 916 330158 325948 89971425
Ear infection 34.72 9.36 399 330675 69376 90227997
Muscle rigidity 34.53 9.36 123 330951 14186 90283187
Myocardial depression 34.47 9.36 24 331050 609 90296764
Burning sensation 34.39 9.36 369 330705 63083 90234290
Pneumocystis jirovecii pneumonia 34.36 9.36 18 331056 21598 90275775
Injection site erythema 34.14 9.36 215 330859 98287 90199086
Respiratory arrest 33.78 9.36 223 330851 33088 90264285
Alanine aminotransferase increased 33.40 9.36 274 330800 118064 90179309
Folliculitis 33.02 9.36 979 330095 203374 90093999
Aspartate aminotransferase increased 33 9.36 230 330844 102707 90194666
Ulcer 32.96 9.36 43 331031 32839 90264534
Musculoskeletal pain 32.92 9.36 839 330235 170412 90126961
Feeling of despair 32.87 9.36 49 331025 3155 90294218
Transplant rejection 32.79 9.36 4 331070 12754 90284619
Victim of sexual abuse 32.45 9.36 24 331050 671 90296702
Cogwheel rigidity 32.06 9.36 39 331035 2063 90295310
Joint swelling 32.05 9.36 1507 329567 501793 89795580
Generalised tonic-clonic seizure 32.03 9.36 228 330846 34675 90262698
Cryopyrin associated periodic syndrome 32.02 9.36 22 331052 546 90296827
Interstitial lung disease 31.80 9.36 157 330917 76248 90221125
Blood calcium decreased 31.79 9.36 38 331036 30144 90267229
Insomnia 31.72 9.36 1506 329568 331968 89965405
Eyelid myoclonus 31.72 9.36 13 331061 105 90297268
Somatic symptom disorder 31.61 9.36 50 331024 3391 90293982
Skin exfoliation 31.57 9.36 134 330940 67779 90229594
Disorientation 31.55 9.36 272 330802 43842 90253531
Foot operation 31.52 9.36 88 330986 8913 90288460
Hepatic enzyme 31.52 9.36 64 331010 5280 90292093
Urinary retention 31.47 9.36 241 330833 37503 90259870
Prescribed underdose 31.29 9.36 415 330659 74604 90222769
Neutrophil count decreased 30.93 9.36 145 330929 71387 90225986
Renal impairment 30.71 9.36 242 330832 105179 90192194
Metastases to liver 30.63 9.36 36 331038 28771 90268602
Rash erythematous 30.55 9.36 128 330946 64976 90232397
Pancreatic fibrosis 30.50 9.36 12 331062 86 90297287
Pleural effusion 30.39 9.36 262 330812 111729 90185644
Psychotic disorder due to a general medical condition 30.25 9.36 16 331058 242 90297131
Nephropathy toxic 30.22 9.36 5 331069 12683 90284690
Chronic kidney disease 30.11 9.36 298 330776 49893 90247480
Vaginal discharge 29.78 9.36 17 331057 19447 90277926
Injection site swelling 29.75 9.36 115 330959 59724 90237649
Female genital tract fistula 29.72 9.36 14 331060 17854 90279519
Tonic clonic movements 29.66 9.36 34 331040 1688 90295685
Amnesia 29.59 9.36 559 330515 107946 90189427
Cyanosis 29.47 9.36 145 330929 19310 90278063
Musculoskeletal disorder 29.32 9.36 157 330917 21612 90275761
Fatigue 29.24 9.36 3732 327342 1150291 89147082
Obstructive airways disorder 28.95 9.36 31 331043 25838 90271535
Sphincter of Oddi dysfunction 28.92 9.36 19 331055 437 90296936
Hypocholesterolaemia 28.71 9.36 69 331005 6380 90290993
Blood parathyroid hormone decreased 28.68 9.36 5 331069 12211 90285162
Product complaint 28.65 9.36 7 331067 13493 90283880
Proctitis 28.56 9.36 10 331064 15249 90282124
Blood glucose increased 28.51 9.36 217 330857 95029 90202344
Pituitary tumour benign 28.45 9.36 37 331037 2095 90295278
Basal cell carcinoma 28.29 9.36 49 331025 33340 90264033
Delirium 28.24 9.36 537 330537 103822 90193551
Cardiac failure 28.03 9.36 260 330814 109236 90188137
Dizziness 28.02 9.36 2508 328566 586776 89710597
Urticaria 27.99 9.36 1404 329670 311330 89986043
Agitation 27.91 9.36 371 330703 66727 90230646
Abdominal discomfort 27.70 9.36 1443 329631 475885 89821488
Malignant neoplasm progression 27.68 9.36 253 330821 106617 90190756
Premature delivery 27.59 9.36 63 331011 38699 90258674
Angina pectoris 27.59 9.36 64 331010 39096 90258277
Infusion related reaction 27.11 9.36 1245 329829 415535 89881838
Bronchiectasis 27.01 9.36 25 331049 22305 90275068
Coma scale abnormal 27.01 9.36 62 331012 5564 90291809
Food allergy 26.91 9.36 32 331042 25446 90271927
Diabetes mellitus inadequate control 26.72 9.36 137 330937 18547 90278826
Visceral congestion 26.57 9.36 17 331057 373 90297000
Sleep disorder due to a general medical condition 26.53 9.36 265 330809 44473 90252900
Drug tolerance decreased 26.46 9.36 48 331026 32082 90265291
Substance abuse 26.43 9.36 60 331014 5346 90292027
Pain 26.21 9.36 3214 327860 993127 89304246
Panniculitis 26.18 9.36 10 331064 14448 90282925
Blood pressure systolic increased 25.98 9.36 117 330957 58228 90239145
Myelodysplastic syndrome 25.77 9.36 23 331051 20880 90276493
Hypoglycaemia 25.74 9.36 378 330696 69470 90227903
Diabetes mellitus 25.48 9.36 136 330938 64739 90232634
Cerebral infarction 25.42 9.36 36 331038 26560 90270813
Arthralgia 25.26 9.36 2475 328599 776047 89521326
Pre-eclampsia 24.92 9.36 5 331069 11043 90286330
Hypertension 24.85 9.36 1967 329107 455565 89841808
Cestode infection 24.71 9.36 15 331059 299 90297074
Hyperacusis 24.66 9.36 40 331034 2771 90294602
Radiculopathy 24.49 9.36 19 331055 18486 90278887
Colitis ulcerative 24.42 9.36 125 330949 60141 90237232
Hypophagia 24.36 9.36 219 330855 35718 90261655
Somatosensory evoked potentials abnormal 24.35 9.36 7 331067 15 90297358
Renal disorder 24.29 9.36 228 330846 37631 90259742
Hypothermia 24.25 9.36 117 330957 15458 90281915
Lung neoplasm malignant 24.06 9.36 32 331042 24241 90273132
Condition aggravated 23.92 9.36 1862 329212 593683 89703690
Death 23.70 9.36 1956 329118 454595 89842778
Eagle Barrett syndrome 23.56 9.36 6 331068 6 90297367
Sinus congestion 23.46 9.36 40 331034 27384 90269989
Caesarean section 23.43 9.36 20 331054 18557 90278816
Infusion site reaction 23.43 9.36 134 330940 18905 90278468
Encephalopathy 23.29 9.36 266 330808 46178 90251195
Carotid artery thrombosis 23.00 9.36 3 331071 9089 90288284
Haemophagocytic lymphohistiocytosis 22.95 9.36 14 331060 15445 90281928
Altered state of consciousness 22.85 9.36 195 330879 31337 90266036
Pseudomonas infection 22.72 9.36 13 331061 14852 90282521
Brain injury 22.66 9.36 71 331003 7667 90289706
Blood bilirubin increased 22.61 9.36 82 330992 43388 90253985
Liver injury 22.57 9.36 798 330276 169769 90127604
Muscle tone disorder 22.47 9.36 11 331063 140 90297233
C-reactive protein increased 22.39 9.36 842 330232 180547 90116826
Myocardial fibrosis 22.32 9.36 22 331052 917 90296456
Acute motor-sensory axonal neuropathy 22.27 9.36 15 331059 360 90297013
Flushing 22.27 9.36 211 330863 88280 90209093
Tuberculosis 22.19 9.36 9 331065 12540 90284833
Electric shock sensation 22.13 9.36 28 331046 1542 90295831
Pneumonia viral 22.11 9.36 3 331071 8820 90288553
Therapeutic product ineffective 22.07 9.36 35 331039 2379 90294994
Hallucinations, mixed 22.04 9.36 59 331015 5830 90291543
Paraesthesia 22.01 9.36 1122 329952 249204 90048169
Arterial occlusive disease 21.89 9.36 9 331065 12437 90284936
Oropharyngeal pain 21.76 9.36 293 330781 114894 90182479
Enthesopathy 21.75 9.36 4 331070 9400 90287973
Suicidal ideation 21.71 9.36 385 330689 73470 90223903
Haematocrit decreased 21.70 9.36 79 330995 41753 90255620
Normal newborn 21.67 9.36 153 330921 23209 90274164
Feeling of body temperature change 21.55 9.36 57 331017 5592 90291781
White blood cell count decreased 21.47 9.36 456 330618 166653 90130720
Throat irritation 21.47 9.36 98 330976 48597 90248776
Arthropathy 21.46 9.36 1106 329968 365136 89932237
Coronary artery disease 21.31 9.36 58 331016 33565 90263808
Influenza like illness 21.24 9.36 190 330884 80421 90216952
Heart rate decreased 21.10 9.36 112 330962 53393 90243980
Chronic sinusitis 21.03 9.36 34 331040 23768 90273605
Congenital central hypoventilation syndrome 20.95 9.36 7 331067 29 90297344
Malaise 20.95 9.36 2446 328628 583540 89713833
Wrong rate 20.94 9.36 11 331063 164 90297209
Lymphopenia 20.87 9.36 32 331042 22849 90274524
Bone marrow failure 20.87 9.36 55 331019 32166 90265207
Rheumatoid arthritis 20.85 9.36 1566 329508 361048 89936325
Magnesium deficiency 20.82 9.36 19 331055 718 90296655
Fracture 20.72 9.36 145 330929 21931 90275442
Ankylosing spondylitis 20.70 9.36 99 330975 13034 90284339
Infection 20.54 9.36 1097 329977 360997 89936376
Blood cholesterol decreased 20.48 9.36 30 331044 1901 90295472
Sedation complication 20.46 9.36 19 331055 16925 90280448
Myoclonus 20.46 9.36 130 330944 19038 90278335
Seronegative arthritis 20.30 9.36 125 330949 18109 90279264
Uveitis 20.21 9.36 17 331057 15886 90281487
Vascular encephalopathy 20.11 9.36 19 331055 751 90296622
Deafness 20.04 9.36 146 330928 22368 90275005
Dissociation 20.02 9.36 62 331012 6653 90290720
Dysphagia 20.00 9.36 289 330785 111989 90185384
Hyperkalaemia 19.92 9.36 147 330927 64817 90232556
Breast disorder 19.84 9.36 36 331038 2731 90294642
Therapeutic product effect incomplete 19.79 9.36 882 330192 193014 90104359
Acne 19.75 9.36 47 331027 28460 90268913
Sacroiliitis 19.71 9.36 46 331028 4173 90293200
Atelectasis 19.63 9.36 37 331037 24372 90273001
Drooling 19.56 9.36 48 331026 4498 90292875
Deformity 19.54 9.36 10 331064 12160 90285213
Coeliac disease 19.53 9.36 249 330825 44361 90253012
Palpitations 19.40 9.36 367 330707 136361 90161012
Haemorrhage 19.39 9.36 161 330913 69208 90228165
Mucosal inflammation 19.34 9.36 127 330947 57498 90239875
Inappropriate schedule of product administration 19.30 9.36 409 330665 149524 90147849
Nasal congestion 19.28 9.36 203 330871 83211 90214162
Body temperature increased 19.11 9.36 91 330983 44619 90252754
Paraesthesia oral 19.05 9.36 56 331018 31603 90265770
Drug withdrawal syndrome neonatal 19.00 9.36 32 331042 2287 90295086
Nightmare 18.83 9.36 140 330934 21585 90275788
Vertigo 18.81 9.36 359 330715 69452 90227921
Ocular hyperaemia 18.77 9.36 62 331012 33736 90263637
Aspergillus infection 18.76 9.36 8 331066 10815 90286558
Hypertonia neonatal 18.61 9.36 12 331062 267 90297106
Adjustment disorder 18.61 9.36 6 331068 9636 90287737
Joint destruction 18.41 9.36 13 331061 13274 90284099
Blood pressure fluctuation 18.37 9.36 114 330960 52299 90245074
Major depression 18.32 9.36 79 330995 9956 90287417
Ascites 18.24 9.36 101 330973 47639 90249734
Blood pressure inadequately controlled 18.13 9.36 57 331017 6167 90291206
Therapy partial responder 18.09 9.36 33 331041 22010 90275363
Sepsis 18.09 9.36 509 330565 179305 90118068
Listless 18.09 9.36 38 331036 3211 90294162
Cytomegalovirus viraemia 18.04 9.36 3 331071 7583 90289790
Acute myocardial infarction 18.03 9.36 66 331008 34824 90262549
Dysphonia 17.89 9.36 327 330747 62757 90234616
Apnoea 17.87 9.36 75 330999 9339 90288034
Vasculitis 17.72 9.36 35 331039 22658 90274715
Speech disorder 17.71 9.36 249 330825 45336 90252037
Cough 17.67 9.36 1136 329938 367826 89929547
Chemical submission 17.65 9.36 15 331059 515 90296858
Complication of device insertion 17.63 9.36 8 331066 10428 90286945
Victim of child abuse 17.62 9.36 5 331069 10 90297363
Arrhythmia 17.61 9.36 87 330987 42245 90255128
Neuroglycopenia 17.52 9.36 21 331053 1094 90296279
Coordination abnormal 17.50 9.36 32 331042 21324 90276049
Substance dependence 17.47 9.36 10 331064 178 90297195
Lymphadenopathy 17.40 9.36 97 330977 45678 90251695
Epstein-Barr virus infection 17.37 9.36 8 331066 10336 90287037
Gangrene 17.32 9.36 13 331061 12863 90284510
Hyponatraemia 17.23 9.36 623 330451 132915 90164458
Feeling drunk 17.14 9.36 47 331027 4711 90292662
Hyperlipasaemia 17.08 9.36 18 331056 813 90296560
Oral candidiasis 17.07 9.36 69 331005 35386 90261987
Spondylitis 16.94 9.36 99 330975 14079 90283294
Tenosynovitis 16.82 9.36 17 331057 14550 90282823
Hyperreflexia 16.73 9.36 58 331016 6599 90290774
Performance enhancing product use 16.72 9.36 5 331069 13 90297360
Disturbance in attention 16.60 9.36 253 330821 46856 90250517
Haemoptysis 16.58 9.36 64 331010 33256 90264117
Accidental overdose 16.54 9.36 167 330907 28106 90269267
Agranulocytosis 16.31 9.36 69 331005 34933 90262440
Cytopenia 16.30 9.36 24 331050 17425 90279948
Neoplasm malignant 16.28 9.36 66 331008 33814 90263559
Poor venous access 16.23 9.36 29 331045 19498 90277875
Muscle spasticity 16.23 9.36 70 331004 35252 90262121
Gastrointestinal haemorrhage 16.17 9.36 232 330842 90016 90207357
Bone lesion 16.11 9.36 56 331018 6381 90290992
Skin lesion 16 9.36 76 330998 37289 90260084
Abortion induced 16.00 9.36 12 331062 11876 90285497
Haemodialysis 15.92 9.36 6 331068 8741 90288632
Epigastric discomfort 15.92 9.36 4 331070 7564 90289809
Degenerative bone disease 15.87 9.36 11 331063 277 90297096
Blood pressure decreased 15.83 9.36 186 330888 74709 90222664
Haematochezia 15.82 9.36 174 330900 70739 90226634
Muscle disorder 15.79 9.36 50 331024 5429 90291944
Pancreatitis acute 15.69 9.36 183 330891 31932 90265441
Angioedema 15.60 9.36 328 330746 64548 90232825
Parosmia 15.57 9.36 59 331015 7010 90290363
Lymphoma 15.53 9.36 16 331058 13575 90283798
Stillbirth 15.53 9.36 4 331070 7439 90289934
Ill-defined disorder 15.49 9.36 825 330249 184066 90113307
Hypocalcaemia 15.45 9.36 91 330983 42277 90255096
Livedo reticularis 15.39 9.36 37 331037 3422 90293951
Breast cancer 15.38 9.36 124 330950 53637 90243736
Dehydration 15.35 9.36 568 330506 193879 90103494
Osteonecrosis of jaw 15.34 9.36 82 330992 39021 90258352
Allergy test negative 15.33 9.36 10 331064 227 90297146
Device dislocation 15.33 9.36 61 331013 31421 90265952
Dermatitis atopic 15.25 9.36 40 331034 23432 90273941
Haemolysis 15.22 9.36 6 331068 8504 90288869
Complication associated with device 15.19 9.36 30 331044 19419 90277954
Joint stiffness 15.18 9.36 383 330691 77659 90219714
Frequent bowel movements 15.09 9.36 134 330940 56801 90240572
Cholelithiasis 15.07 9.36 121 330953 52385 90244988
Cardiomyopathy 15.07 9.36 32 331042 20174 90277199
Pulmonary toxicity 15.06 9.36 12 331062 11519 90285854
Lower limb fracture 15.03 9.36 412 330662 84601 90212772
Vaginal haemorrhage 14.97 9.36 61 331013 31210 90266163
Muscular weakness 14.96 9.36 910 330164 205756 90091617
Respiratory failure 14.96 9.36 324 330750 118094 90179279
Cytomegalovirus infection reactivation 14.79 9.36 5 331069 7795 90289578
Syncope 14.79 9.36 370 330704 132293 90165080
Rectal haemorrhage 14.73 9.36 213 330861 82531 90214842
Bronchopulmonary aspergillosis 14.71 9.36 12 331062 11386 90285987
Eczema 14.65 9.36 123 330951 52747 90244626
Swollen joint count increased 14.64 9.36 520 330554 110686 90186687
Cushingoid 14.63 9.36 10 331064 10385 90286988
Metastases to central nervous system 14.63 9.36 26 331048 17516 90279857
Nasal polyps 14.62 9.36 11 331063 10869 90286504
Neurosis 14.60 9.36 12 331062 393 90296980
Vaccination site reaction 14.60 9.36 10 331064 247 90297126
Thymus disorder 14.53 9.36 11 331063 319 90297054
Diastolic hypotension 14.45 9.36 7 331067 87 90297286
Rhinitis 14.39 9.36 17 331057 13555 90283818
Visual acuity reduced 14.38 9.36 41 331033 23369 90274004
Herpes zoster 14.38 9.36 251 330823 94393 90202980
Breast cancer female 14.38 9.36 20 331054 14866 90282507
Device ineffective 14.35 9.36 10 331064 254 90297119
Acute myeloid leukaemia 14.32 9.36 34 331040 20606 90276767
Unintended pregnancy 14.30 9.36 5 331069 7632 90289741
Atypical femur fracture 14.29 9.36 3 331071 6418 90290955
Eosinophil count increased 14.28 9.36 16 331058 13065 90284308
Haemolytic anaemia 14.26 9.36 13 331061 11684 90285689
Progressive multifocal leukoencephalopathy 14.17 9.36 22 331052 15633 90281740
Bladder prolapse 14.15 9.36 27 331047 2128 90295245
Cholangiectasis acquired 14.10 9.36 4 331070 8 90297365
Congenital diaphragmatic eventration 14.10 9.36 4 331070 8 90297365
SARS-CoV-2 test positive 14.01 9.36 12 331062 11116 90286257
General physical health deterioration 13.99 9.36 1492 329582 353623 89943750
Platelet count increased 13.97 9.36 35 331039 20824 90276549
Colitis 13.91 9.36 176 330898 69766 90227607
Faecaloma 13.89 9.36 75 330999 10356 90287017
Personality disorder 13.83 9.36 15 331059 12429 90284944
Inadequate analgesia 13.82 9.36 34 331040 3190 90294183
Middle insomnia 13.82 9.36 25 331049 16726 90280647
Cleft uvula 13.78 9.36 4 331070 9 90297364
Incorrect dose administered 13.76 9.36 204 330870 78726 90218647
Thermal burn 13.73 9.36 55 331019 6707 90290666
Bronchospasm 13.68 9.36 35 331039 20674 90276699
Joint dislocation 13.68 9.36 234 330840 44348 90253025
Injection site extravasation 13.62 9.36 8 331066 9011 90288362
Enterococcal infection 13.55 9.36 10 331064 9981 90287392
Ear pruritus 13.55 9.36 4 331070 6799 90290574
Hepatic enzyme increased 13.51 9.36 1134 329940 359602 89937771
Purple glove syndrome 13.47 9.36 9 331065 213 90297160
Cholangiocarcinoma 13.47 9.36 20 331054 1283 90296090
Coagulopathy 13.43 9.36 42 331032 23247 90274126
Foetal malnutrition 13.41 9.36 7 331067 103 90297270
Menstrual disorder 13.33 9.36 51 331023 6087 90291286
Gallbladder polyp 13.19 9.36 17 331057 954 90296419
Liver disorder 13.11 9.36 555 330519 120714 90176659
Psychomotor skills impaired 13.08 9.36 31 331043 2841 90294532
Perineal fistula 13.06 9.36 7 331067 109 90297264
Hypersensitivity vasculitis 12.96 9.36 39 331035 4120 90293253
Sinusitis 12.93 9.36 1078 329996 342010 89955363
Umbilical hernia 12.91 9.36 36 331038 3644 90293729
Anti-cyclic citrullinated peptide antibody 12.80 9.36 154 330920 27067 90270306
Arthritis 12.71 9.36 491 330583 166824 90130549
Accidental death 12.64 9.36 25 331049 2023 90295350
Underdose 12.63 9.36 272 330802 53745 90243628
Dyslipidaemia 12.60 9.36 11 331063 10096 90287277
Influenza 12.57 9.36 400 330674 138864 90158509
Ovarian hyperstimulation syndrome 12.52 9.36 3 331071 5859 90291514
Hand dermatitis 12.48 9.36 13 331061 579 90296794
Growth disorder 12.46 9.36 5 331069 38 90297335
Loss of consciousness 12.40 9.36 629 330445 139609 90157764
Restless legs syndrome 12.32 9.36 131 330943 22339 90275034
Hypotension 12.32 9.36 1022 330052 324375 89972998
Pleuritic pain 12.32 9.36 12 331062 10449 90286924
Spinal fusion surgery 12.31 9.36 82 330992 12201 90285172
Premenstrual syndrome 12.31 9.36 15 331059 795 90296578
Glaucoma 12.28 9.36 37 331037 20718 90276655
Respiratory rate increased 12.22 9.36 25 331049 15976 90281397
Metastases to lung 12.20 9.36 25 331049 15966 90281407
Gastrointestinal toxicity 12.18 9.36 10 331064 9457 90287916
Rectal prolapse 12.03 9.36 26 331048 2241 90295132
Fluid retention 12.02 9.36 238 330836 87853 90209520
Mixed anxiety and depressive disorder 11.92 9.36 11 331063 422 90296951
Anoxia 11.92 9.36 9 331065 260 90297113
Walking aid user 11.87 9.36 189 330885 35317 90262056
Electrocardiogram QT interval 11.84 9.36 8 331066 193 90297180
Stomatitis 11.80 9.36 1161 329913 273537 90023836
Limb injury 11.80 9.36 171 330903 31337 90266036
Chronic obstructive pulmonary disease 11.80 9.36 194 330880 73635 90223738
Skin toxicity 11.77 9.36 5 331069 6774 90290599
Lupus-like syndrome 11.76 9.36 247 330827 48599 90248774
Pulmonary hypertension 11.75 9.36 99 330975 42424 90254949
Drug dose omission by device 11.74 9.36 12 331062 10219 90287154
Abdominal wound dehiscence 11.74 9.36 9 331065 266 90297107
Brachial artery entrapment syndrome 11.73 9.36 5 331069 45 90297328
Euglycaemic diabetic ketoacidosis 11.72 9.36 4 331070 6197 90291176
Sarcoidosis 11.71 9.36 13 331061 10660 90286713
Bacterial infection 11.69 9.36 45 331029 23399 90273974
Skin fissures 11.67 9.36 38 331036 20771 90276602
Injection site pruritus 11.65 9.36 133 330941 53701 90243672
Systemic lupus erythematosus 11.62 9.36 1151 329923 360745 89936628
Fear of disease 11.61 9.36 20 331054 1456 90295917
Nodular rash 11.59 9.36 8 331066 200 90297173
Migraine 11.56 9.36 826 330248 189566 90107807
Nystagmus 11.51 9.36 6 331068 7221 90290152
Pulmonary mass 11.47 9.36 60 331014 28712 90268661
Stupor 11.46 9.36 45 331029 5437 90291936
Lip pruritus 11.46 9.36 19 331055 1341 90296032
Knee operation 11.45 9.36 53 331021 6883 90290490
Diabetic ketoacidosis 11.44 9.36 48 331026 24359 90273014
Candida endophthalmitis 11.36 9.36 5 331069 49 90297324
Skin haemorrhage 11.34 9.36 40 331034 21340 90276033
Hypertonia 11.34 9.36 43 331031 5112 90292261
Product storage error 11.33 9.36 37 331037 20204 90277169
Diffuse large B-cell lymphoma 11.28 9.36 9 331065 8636 90288737
Impaired healing 11.28 9.36 998 330076 233201 90064172
Carcinoembryonic antigen 11.27 9.36 6 331068 92 90297281
Pulmonary embolism 11.27 9.36 378 330696 130442 90166931
Tricuspid valve incompetence 11.26 9.36 28 331046 16703 90280670
Lymphomatoid papulosis 11.25 9.36 7 331067 146 90297227
Rash pruritic 11.25 9.36 222 330852 81992 90215381
Glossodynia 11.24 9.36 1017 330057 320762 89976611
Hypercalcaemia 11.22 9.36 76 330998 34164 90263209
Congenital muscle absence 11.21 9.36 4 331070 21 90297352
Bone disorder 11.13 9.36 45 331029 23075 90274298
Neuromyopathy 11.12 9.36 14 331060 767 90296606
Antibiotic therapy 11.12 9.36 18 331056 1245 90296128
Skin ulcer 11.11 9.36 123 330951 49952 90247421
Skin plaque 11.11 9.36 12 331062 9963 90287410
Tongue disorder 11.09 9.36 14 331060 10846 90286527
Gastroenteritis 11.08 9.36 62 331012 29167 90268206
Mood swings 11.03 9.36 120 330954 20582 90276791
Second primary malignancy 11.00 9.36 13 331061 10365 90287008
Hypoxia 11.00 9.36 192 330882 72207 90225166
Renal cyst 10.98 9.36 19 331055 12931 90284442
Bradycardia foetal 10.96 9.36 12 331062 566 90296807
Unintentional medical device removal 10.96 9.36 6 331068 7024 90290349
Carbohydrate antigen 15-3 10.94 9.36 6 331068 98 90297275
Moebius II syndrome 10.91 9.36 4 331070 23 90297350
Maternal exposure before pregnancy 10.89 9.36 15 331059 11198 90286175
Polymenorrhoea 10.88 9.36 19 331055 1398 90295975
Acquired cystic kidney disease 10.86 9.36 5 331069 55 90297318
Skin disorder 10.81 9.36 84 330990 36622 90260751
Hypernatraemia 10.79 9.36 11 331063 9376 90287997
Rebound effect 10.78 9.36 11 331063 9373 90288000
Akathisia 10.77 9.36 15 331059 11144 90286229
Post cardiac arrest syndrome 10.77 9.36 4 331070 24 90297349
Cholinergic syndrome 10.76 9.36 13 331061 683 90296690
Ventricular extrasystoles 10.73 9.36 20 331054 13230 90284143
Oral lichenoid reaction 10.73 9.36 6 331068 102 90297271
Cryoglobulinaemia 10.72 9.36 14 331060 796 90296577
Encephalitis 10.71 9.36 15 331059 11119 90286254
Hypotonia 10.69 9.36 75 330999 11351 90286022
Nausea 10.68 9.36 4352 326722 1105964 89191409
Injection site haematoma 10.66 9.36 6 331068 6916 90290457
Central nervous system stimulation 10.62 9.36 5 331069 58 90297315
Carotid pulse abnormal 10.57 9.36 3 331071 6 90297367
Device difficult to use 10.54 9.36 31 331043 17494 90279879
Thoracic radiculopathy 10.50 9.36 4 331070 26 90297347
Scleritis 10.48 9.36 3 331071 5205 90292168
Disinhibition 10.48 9.36 16 331058 1052 90296321
Liver function test abnormal 10.47 9.36 127 330947 50718 90246655
Alkalosis hypochloraemic 10.45 9.36 8 331066 236 90297137
Nephrotic syndrome 10.41 9.36 7 331067 7332 90290041
Prothrombin level increased 10.39 9.36 9 331065 317 90297056
Escherichia infection 10.39 9.36 27 331047 15868 90281505
Cardiovascular disorder 10.37 9.36 21 331053 13471 90283902
Bacteraemia 10.36 9.36 44 331030 22256 90275117
Staphylococcal infection 10.35 9.36 120 330954 48319 90249054
Alcohol interaction 10.34 9.36 21 331053 1733 90295640
Escherichia bacteraemia 10.33 9.36 4 331070 5731 90291642
Deep vein thrombosis postoperative 10.30 9.36 335 330739 70474 90226899
Schizoaffective disorder 10.30 9.36 3 331071 5144 90292229
Suspected suicide 10.28 9.36 65 331009 9503 90287870
Subileus 10.27 9.36 33 331041 3611 90293762
Life support 10.25 9.36 8 331066 243 90297130
Depressed level of consciousness 10.24 9.36 343 330731 72441 90224932
Product expiration date issue 10.19 9.36 5 331069 64 90297309
Hair colour changes 10.18 9.36 32 331042 3462 90293911
Somnolence neonatal 10.14 9.36 6 331068 114 90297259
Oxygen saturation decreased 10.12 9.36 307 330767 107176 90190197
Lichen sclerosus 10.11 9.36 18 331056 1345 90296028
No adverse event 10.10 9.36 181 330893 67801 90229572
Renal tubular necrosis 10.08 9.36 24 331050 14531 90282842
Clonic convulsion 10.06 9.36 14 331060 846 90296527
Pleural neoplasm 10.06 9.36 10 331064 421 90296952
Injection site urticaria 10.03 9.36 33 331041 17978 90279395
Dry eye 10.00 9.36 150 330924 57781 90239592
Graft versus host disease 9.99 9.36 9 331065 8135 90289238
Device malfunction 9.99 9.36 41 331033 20936 90276437
Procedural pain 9.98 9.36 76 330998 33284 90264089
Bone erosion 9.95 9.36 259 330815 52762 90244611
Oral discomfort 9.92 9.36 69 331005 10414 90286959
Hypoventilation 9.90 9.36 42 331032 5254 90292119
Drug reaction with eosinophilia and systemic symptoms 9.90 9.36 104 330970 42654 90254719
Respiratory depth decreased 9.90 9.36 4 331070 31 90297342
Cardiac disorder 9.87 9.36 275 330799 56597 90240776
Exercise tolerance decreased 9.86 9.36 54 331020 7497 90289876
Initial insomnia 9.85 9.36 63 331011 9247 90288126
Incorrect product administration duration 9.84 9.36 111 330963 19211 90278162
Pruritus 9.82 9.36 1785 329289 539740 89757633
Peripheral swelling 9.81 9.36 1684 329390 411422 89885951
Transcription medication error 9.81 9.36 8 331066 259 90297114
Osteonecrosis 9.76 9.36 56 331018 26185 90271188
Hemiparesis 9.76 9.36 72 331002 31747 90265626
Intraocular pressure increased 9.75 9.36 7 331067 7086 90290287
Poverty 9.72 9.36 3 331071 9 90297364
Systemic candida 9.72 9.36 3 331071 4956 90292417
Product preparation error 9.70 9.36 14 331060 10247 90287126
Hypogammaglobulinaemia 9.66 9.36 15 331059 10659 90286714
Hypercapnic coma 9.66 9.36 8 331066 265 90297108
Toothache 9.64 9.36 45 331029 22185 90275188
Peritoneal perforation 9.61 9.36 6 331068 126 90297247
Haematoma muscle 9.57 9.36 21 331053 1829 90295544
Heart rate increased 9.55 9.36 327 330747 112575 90184798
Anaphylactic reaction 9.52 9.36 245 330829 87279 90210094
Rales 9.52 9.36 28 331046 15799 90281574
Urine glucose/creatinine ratio increased 9.49 9.36 7 331067 195 90297178
White blood cells urine positive 9.49 9.36 6 331068 6492 90290881
Gallbladder cholesterolosis 9.48 9.36 13 331061 775 90296598
Benzodiazepine drug level increased 9.46 9.36 7 331067 196 90297177
Tinnitus 9.43 9.36 215 330859 42887 90254486
Dysphoria 9.42 9.36 46 331028 6108 90291265
Crohn's disease 9.39 9.36 3 331071 4848 90292525
Tachyarrhythmia 9.36 9.36 4 331070 5402 90291971

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1414.87 10.57 1527 106688 103244 42409876
Drug dependence 1191.73 10.57 804 107411 28290 42484830
Drug use disorder 924.97 10.57 474 107741 9859 42503261
Toxicity to various agents 682.57 10.57 1674 106541 227462 42285658
Poisoning deliberate 540.69 10.57 331 107884 9803 42503317
Coma 462.34 10.57 623 107592 52931 42460189
Prescription form tampering 455.98 10.57 132 108083 480 42512640
Intentional overdose 434.15 10.57 592 107623 50864 42462256
Serotonin syndrome 420.31 10.57 417 107798 25428 42487692
Overdose 417.50 10.57 863 107352 104401 42408719
Intentional product misuse 376.74 10.57 611 107604 61289 42451831
Miosis 347.86 10.57 282 107933 13164 42499956
Withdrawal syndrome 342.96 10.57 291 107924 14484 42498636
Bradypnoea 195.57 10.57 128 108087 4265 42508855
Completed suicide 188.52 10.57 606 107609 95859 42417261
Suicide attempt 183.67 10.57 379 107836 45721 42467399
Somnolence 183.61 10.57 777 107438 140328 42372792
Confusional state 168.68 10.57 856 107359 166741 42346379
Substance use disorder 161.75 10.57 123 108092 5222 42507898
Respiratory depression 152.84 10.57 213 108002 18655 42494465
Off label use 146.60 10.57 986 107229 637349 41875771
Poisoning 142.21 10.57 181 108034 14518 42498602
Asphyxia 129.15 10.57 131 108084 8195 42504925
Prescription drug used without a prescription 127.55 10.57 82 108133 2648 42510472
Mydriasis 112.97 10.57 125 108090 8645 42504475
Generalised tonic-clonic seizure 108.73 10.57 220 107995 26159 42486961
Drug dispensed to wrong patient 108.35 10.57 43 108172 474 42512646
Seizure 95.22 10.57 577 107638 119984 42393136
Drug withdrawal syndrome 90.34 10.57 181 108034 21368 42491752
Hyperhidrosis 78.43 10.57 444 107771 90068 42423052
Disorientation 76.87 10.57 235 107980 36154 42476966
Loss of consciousness 76.08 10.57 447 107768 91907 42421213
Hypoglycaemia 73.40 10.57 324 107891 59530 42453590
Altered state of consciousness 70.46 10.57 198 108017 29061 42484059
Depressed level of consciousness 70.06 10.57 274 107941 47696 42465424
Wrong patient received product 69.97 10.57 64 108151 3519 42509601
Drug interaction 69.90 10.57 1007 107208 265992 42247128
Dependence 68.02 10.57 44 108171 1436 42511684
Death 64.06 10.57 1606 106609 469579 42043541
Antimicrobial susceptibility test resistant 62.85 10.57 27 108188 369 42512751
Hepatocellular injury 61.76 10.57 165 108050 23513 42489607
Hallucination 61.43 10.57 299 107916 57208 42455912
Housebound 61.22 10.57 23 108192 216 42512904
Minimum inhibitory concentration 60.53 10.57 21 108194 153 42512967
Agitation 60.05 10.57 322 107893 63992 42449128
Disease progression 59.93 10.57 177 108038 143479 42369641
Drug resistance 57.57 10.57 9 108206 34239 42478881
Epilepsy 57.14 10.57 171 108044 26000 42487120
Physical deconditioning 57.09 10.57 48 108167 2357 42510763
Drug ineffective 56.13 10.57 1198 107017 628999 41884121
Nightmare 56.10 10.57 165 108050 24847 42488273
Myelosuppression 55.18 10.57 17 108198 40444 42472676
Myoclonus 52.94 10.57 127 108088 16938 42496182
Cholestasis 52.29 10.57 193 108022 32686 42480434
Antidepressant drug level above therapeutic 51.25 10.57 21 108194 253 42512867
Analgesic drug level above therapeutic 50.67 10.57 22 108193 309 42512811
Constipation 50.61 10.57 632 107583 161659 42351461
Sedation 50.24 10.57 181 108034 30294 42482826
Febrile neutropenia 49.50 10.57 273 107942 185430 42327690
Therapeutic response delayed 44.89 10.57 26 108189 693 42512427
Drug diversion 44.52 10.57 29 108186 958 42512162
Aggression 42.50 10.57 223 107992 43940 42469180
Inadequate analgesia 41.92 10.57 46 108169 3151 42509969
Hyper IgE syndrome 41.52 10.57 16 108199 162 42512958
Major depression 40.84 10.57 59 108156 5339 42507781
Hallucination, visual 40.03 10.57 131 108084 20889 42492231
Pyrexia 39.16 10.57 735 107480 393307 42119813
Vomiting 38.46 10.57 985 107230 288738 42224382
Behaviour disorder 38.00 10.57 66 108149 6988 42506132
Narcotic bowel syndrome 37.31 10.57 14 108201 131 42512989
Tonic convulsion 37.10 10.57 32 108183 1627 42511493
Analgesic drug level increased 36.88 10.57 27 108188 1081 42512039
Cardio-respiratory arrest 36.74 10.57 265 107950 58371 42454749
Accidental overdose 36.73 10.57 156 108059 28174 42484946
Treatment failure 35.90 10.57 65 108150 62559 42450561
Myocardial fibrosis 35.65 10.57 28 108187 1247 42511873
Condition aggravated 34.75 10.57 460 107755 260294 42252826
Pneumonia aspiration 34.72 10.57 232 107983 49846 42463274
Hyperaesthesia 33.79 10.57 57 108158 5895 42507225
Stress 32.05 10.57 39 108176 44173 42468947
Inappropriate antidiuretic hormone secretion 31.42 10.57 103 108112 16438 42496682
Cough 31.31 10.57 295 107920 177808 42335312
Respiratory acidosis 31.23 10.57 57 108158 6274 42506846
Expired product administered 30.77 10.57 45 108170 4118 42509002
Nausea 30.73 10.57 1265 106950 395534 42117586
Anal haemorrhage 30.38 10.57 37 108178 2836 42510284
Alanine aminotransferase increased 30.00 10.57 119 108096 88287 42424833
Bronchiectasis 29.69 10.57 5 108210 18014 42495106
Drug tolerance 29.45 10.57 39 108176 3251 42509869
Adrenergic syndrome 29.40 10.57 12 108203 143 42512977
Drug detoxification 29.40 10.57 16 108199 377 42512743
Parasomnia 29.39 10.57 17 108198 452 42512668
Full blood count abnormal 29.21 10.57 20 108195 29856 42483264
Pulmonary oedema 29.02 10.57 233 107982 53039 42460081
Suicidal behaviour 29.00 10.57 27 108188 1519 42511601
Joint dislocation 28.98 10.57 45 108170 4342 42508778
Disease recurrence 28.84 10.57 20 108195 29658 42483462
Foetal disorder 28.68 10.57 23 108192 1056 42512064
Mucosal inflammation 28.52 10.57 51 108164 49323 42463797
Drug hypersensitivity 27.98 10.57 380 107835 99009 42414111
Logorrhoea 27.83 10.57 35 108180 2772 42510348
Urinary retention 27.73 10.57 193 108022 42021 42471099
Anterograde amnesia 27.52 10.57 14 108201 286 42512834
Appendicitis 27.50 10.57 9 108206 20604 42492516
Arteriovenous fistula 27.36 10.57 23 108192 1129 42511991
Polyneuropathy in malignant disease 27.27 10.57 15 108200 361 42512759
Drug screen positive 26.76 10.57 42 108173 4089 42509031
Myocardial infarction 26.50 10.57 195 108020 123814 42389306
Substance dependence 26.36 10.57 18 108197 644 42512476
Cytomegalovirus infection 26.17 10.57 26 108189 32280 42480840
White blood cell count decreased 25.85 10.57 169 108046 110227 42402893
Fall 25.65 10.57 778 107437 233742 42279378
Inappropriate schedule of product administration 25.51 10.57 141 108074 95761 42417359
Sepsis 25.32 10.57 355 107860 198979 42314141
Apnoea 25.20 10.57 59 108156 7744 42505376
Activated partial thromboplastin time prolonged 24.94 10.57 5 108210 15898 42497222
Product dispensing error 24.94 10.57 58 108157 7581 42505539
Accidental exposure to product by child 24.93 10.57 25 108190 1542 42511578
Therapy partial responder 24.58 10.57 10 108205 20011 42493109
Oedematous pancreatitis 24.10 10.57 18 108197 743 42512377
Hyperacusis 24.05 10.57 20 108195 967 42512153
Drug reaction with eosinophilia and systemic symptoms 24.00 10.57 186 108029 41889 42471231
Tonic clonic movements 23.97 10.57 23 108192 1344 42511776
Acidosis 23.81 10.57 77 108138 12202 42500918
Ventricular fibrillation 23.54 10.57 25 108190 30098 42483022
Injection site pain 23.51 10.57 72 108143 57726 42455394
Euphoric mood 23.30 10.57 51 108164 6402 42506718
Platelet count decreased 23.30 10.57 232 107983 138349 42374771
Wheezing 23.17 10.57 67 108148 54714 42458406
Neutropenia neonatal 23.16 10.57 19 108196 901 42512219
Chemical poisoning 22.69 10.57 9 108206 99 42513021
Cardiac failure congestive 22.69 10.57 126 108089 85476 42427644
Drug withdrawal convulsions 22.50 10.57 22 108193 1316 42511804
Hallucinations, mixed 22.36 10.57 35 108180 3400 42509720
Confusion postoperative 22.20 10.57 10 108205 154 42512966
Product use in unapproved indication 22.20 10.57 332 107883 184124 42328996
Haemoglobin decreased 22.17 10.57 222 107993 132249 42380871
Spinal operation 22.11 10.57 39 108176 4181 42508939
Body mass index abnormal 21.58 10.57 10 108205 165 42512955
Cutaneous T-cell lymphoma stage I 21.56 10.57 9 108206 114 42513006
Aspartate aminotransferase increased 21.32 10.57 112 108103 77051 42436069
Puncture site haematoma 21.26 10.57 10 108205 171 42512949
Wrong product administered 21.13 10.57 48 108167 6178 42506942
Formication 21.12 10.57 26 108189 2015 42511105
Hepatic cytolysis 20.84 10.57 128 108087 26716 42486404
Postoperative delirium 20.83 10.57 15 108200 585 42512535
Hanging 20.75 10.57 10 108205 181 42512939
Pulmonary alveolar haemorrhage 20.61 10.57 6 108209 14810 42498310
Hyperphosphataemia 20.58 10.57 4 108211 13000 42500120
Urethral valves 20.57 10.57 11 108204 250 42512870
Graft versus host disease 20.40 10.57 4 108211 12921 42500199
Gas poisoning 20.34 10.57 8 108207 86 42513034
Allodynia 20.31 10.57 19 108196 1075 42512045
Vascular malformation 20.25 10.57 8 108207 87 42513033
Cardiac murmur 20.07 10.57 4 108211 12771 42500349
Frequent bowel movements 20.05 10.57 15 108200 21392 42491728
Oesophagitis chemical 19.95 10.57 7 108208 53 42513067
Intentional self-injury 19.93 10.57 84 108131 15118 42498002
Faecaloma 19.81 10.57 47 108168 6223 42506897
Hypoosmolar state 19.51 10.57 9 108206 147 42512973
Road traffic accident 19.47 10.57 98 108117 18995 42494125
Hyperthermia 19.31 10.57 73 108142 12501 42500619
Tachycardia 19.20 10.57 362 107853 100725 42412395
Aplastic anaemia 19.20 10.57 4 108211 12380 42500740
Multiple organ dysfunction syndrome 19.12 10.57 156 108059 96879 42416241
COVID-19 19.11 10.57 195 108020 115753 42397367
Dyspnoea 19.11 10.57 924 107291 441697 42071423
Suspected suicide 19.08 10.57 46 108169 6153 42506967
Ascites 18.77 10.57 77 108138 56601 42456519
Visceral congestion 18.75 10.57 17 108198 924 42512196
Respiratory symptom 18.48 10.57 3 108212 11103 42502017
Mixed anxiety and depressive disorder 18.47 10.57 10 108205 233 42512887
Myasthenia gravis 18.34 10.57 9 108206 16128 42496992
Haemophagocytic lymphohistiocytosis 18.08 10.57 12 108203 18210 42494910
Transplant rejection 18.01 10.57 6 108209 13582 42499538
Sleep disorder due to a general medical condition 17.99 10.57 11 108204 17442 42495678
Symmetrical drug-related intertriginous and flexural exanthema 17.92 10.57 16 108199 852 42512268
Pulmonary embolism 17.78 10.57 206 108009 119406 42393714
Aspergillus infection 17.74 10.57 9 108206 15828 42497292
Acute cutaneous lupus erythematosus 17.49 10.57 7 108208 79 42513041
Acute myocardial infarction 17.46 10.57 82 108133 58083 42455037
Suicidal ideation 17.38 10.57 193 108022 47968 42465152
Cerebral infarction 17.28 10.57 33 108182 31136 42481984
Product administration error 17.21 10.57 92 108123 18251 42494869
Central-alveolar hypoventilation 17.15 10.57 4 108211 4 42513116
Product substitution 17.15 10.57 6 108209 45 42513075
No adverse event 17.04 10.57 47 108168 38974 42474146
Drug withdrawal syndrome neonatal 16.96 10.57 36 108179 4425 42508695
Insomnia 16.81 10.57 406 107809 117847 42395273
Faecal disimpaction 16.70 10.57 5 108210 21 42513099
Acute kidney injury 16.56 10.57 1113 107102 366224 42146896
Pneumonia 16.53 10.57 890 107325 421259 42091861
Pseudomonas infection 16.46 10.57 10 108205 15913 42497207
Tooth injury 16.40 10.57 18 108197 1233 42511887
Renal impairment 16.32 10.57 190 108025 110038 42403082
Decompression sickness 16.26 10.57 4 108211 6 42513114
Leukopenia 16.21 10.57 117 108098 74629 42438491
Neurological symptom 15.97 10.57 3 108212 9988 42503132
Negative pressure pulmonary oedema 15.93 10.57 13 108202 612 42512508
Bladder cancer 15.89 10.57 12 108203 17035 42496085
Productive cough 15.89 10.57 72 108143 51495 42461625
Ligament calcification 15.81 10.57 9 108206 232 42512888
Theft 15.81 10.57 9 108206 232 42512888
Blood phosphorus increased 15.80 10.57 6 108209 12519 42500601
Alcohol abuse 15.77 10.57 33 108182 4016 42509104
Obstructive airways disorder 15.76 10.57 24 108191 24735 42488385
Haemorrhagic fever 15.68 10.57 5 108210 27 42513093
Incision site haematoma 15.65 10.57 7 108208 106 42513014
Quality of life decreased 15.60 10.57 39 108176 5337 42507783
Neuroleptic malignant syndrome 15.50 10.57 19 108196 21453 42491667
Perineal infection 15.45 10.57 13 108202 639 42512481
Neutrophil count decreased 15.39 10.57 96 108119 63319 42449801
Product dose omission issue 15.24 10.57 288 107927 154077 42359043
Drug abuser 15.20 10.57 30 108185 3501 42509619
Schizophrenia 15.18 10.57 4 108211 10546 42502574
Hyponatraemic seizure 15.11 10.57 8 108207 178 42512942
Epilepsy with myoclonic-atonic seizures 14.94 10.57 3 108212 0 42513120
Tongue biting 14.88 10.57 16 108199 1071 42512049
Substance abuse 14.77 10.57 53 108162 8852 42504268
Cytomegalovirus infection reactivation 14.70 10.57 5 108210 11173 42501947
Prothrombin time shortened 14.48 10.57 19 108196 1570 42511550
Post stroke epilepsy 14.46 10.57 5 108210 36 42513084
Therapeutic product effect incomplete 14.45 10.57 113 108102 70826 42442294
Therapeutic product effect decreased 14.38 10.57 51 108164 39099 42474021
Gastric bypass 14.35 10.57 9 108206 278 42512842
Blood creatinine increased 14.27 10.57 195 108020 109808 42403312
Abnormal sleep-related event 14.22 10.57 11 108204 479 42512641
Optic nerve operation 14.18 10.57 11 108204 481 42512639
Clonus 14.07 10.57 29 108186 3491 42509629
Diabetes mellitus 14.05 10.57 92 108123 59995 42453125
Red blood cell sedimentation rate increased 13.84 10.57 4 108211 9920 42503200
Eosinophilic pneumonia chronic 13.80 10.57 9 108206 298 42512822
Asthma 13.78 10.57 97 108118 62217 42450903
Lymphopenia 13.63 10.57 21 108194 21542 42491578
Product used for unknown indication 13.57 10.57 16 108199 1185 42511935
Bladder dilatation 13.56 10.57 19 108196 1671 42511449
Discoloured vomit 13.56 10.57 13 108202 759 42512361
Electrocution 13.52 10.57 4 108211 16 42513104
Somnambulism 13.50 10.57 28 108187 3387 42509733
Bacterial infection 13.39 10.57 32 108183 27847 42485273
Oesophageal carcinoma 13.35 10.57 4 108211 9692 42503428
BK virus infection 13.29 10.57 3 108212 8781 42504339
Capillary fragility 13.12 10.57 5 108210 49 42513071
Nephrolithiasis 13.02 10.57 147 108068 36683 42476437
Interstitial lung disease 12.91 10.57 132 108083 78330 42434790
Torsade de pointes 12.87 10.57 3 108212 8591 42504529
Victim of abuse 12.86 10.57 3 108212 3 42513117
Hydroxyprolinuria 12.86 10.57 3 108212 3 42513117
Device leakage 12.85 10.57 5 108210 10280 42502840
SARS-CoV-2 test false positive 12.80 10.57 4 108211 20 42513100
Oxygen saturation decreased 12.74 10.57 233 107982 64454 42448666
Weaning failure 12.70 10.57 8 108207 249 42512871
Haemophilic arthropathy 12.68 10.57 8 108207 250 42512870
Ventricular tachycardia 12.67 10.57 37 108178 30123 42482997
Product storage error 12.67 10.57 59 108156 11081 42502039
Influenza virus test positive 12.63 10.57 7 108208 171 42512949
Hepatic cancer 12.62 10.57 3 108212 8477 42504643
Accidental poisoning 12.60 10.57 16 108199 1280 42511840
Scrotal infection 12.59 10.57 13 108202 830 42512290
Spleen congestion 12.57 10.57 9 108206 348 42512772
Therapeutic drug monitoring analysis not performed 12.56 10.57 11 108204 571 42512549
Immune reconstitution inflammatory syndrome 12.56 10.57 5 108210 10138 42502982
Hepatic function abnormal 12.54 10.57 78 108137 51489 42461631
Sweat gland disorder 12.53 10.57 6 108209 107 42513013
Congenital heart valve disorder 12.45 10.57 5 108210 57 42513063
Otospondylomegaepiphyseal dysplasia 12.38 10.57 6 108209 110 42513010
Respiratory failure 12.35 10.57 240 107975 127892 42385228
Hypothyroidism 12.32 10.57 41 108174 32043 42481077
Pleural mesothelioma 12.28 10.57 6 108209 112 42513008
Pulmonary congestion 12.21 10.57 75 108140 15655 42497465
Femoral artery aneurysm 12.17 10.57 7 108208 184 42512936
Electric shock sensation 12.12 10.57 10 108205 478 42512642
Blood glucose increased 12.12 10.57 124 108091 73575 42439545
Substance abuser 12.10 10.57 8 108207 271 42512849
Blood pressure increased 12.06 10.57 184 108031 101744 42411376
Wrong strength 11.91 10.57 6 108209 120 42513000
Precancerous condition 11.91 10.57 6 108209 120 42513000
Gallbladder injury 11.87 10.57 7 108208 193 42512927
Drug screen false positive 11.86 10.57 13 108202 889 42512231
Tendon pain 11.82 10.57 26 108189 3274 42509846
Nerve injury 11.82 10.57 29 108186 3921 42509199
Limb fracture 11.79 10.57 4 108211 27 42513093
Hypophosphataemia 11.77 10.57 22 108193 20923 42492197
Lentigo maligna 11.75 10.57 9 108206 386 42512734
Hyperlipidaemia 11.74 10.57 23 108192 21493 42491627
Psychomotor hyperactivity 11.71 10.57 57 108158 10901 42502219
Increased appetite 11.69 10.57 4 108211 8902 42504218
Antiphospholipid antibodies positive 11.57 10.57 9 108206 395 42512725
Impaired reasoning 11.56 10.57 6 108209 128 42512992
Dehydration 11.50 10.57 273 107942 141494 42371626
Atrial septal defect 11.40 10.57 3 108212 7916 42505204
Pre-existing condition improved 11.37 10.57 24 108191 2939 42510181
Delirium 11.36 10.57 192 108023 52327 42460793
Glutathione decreased 11.34 10.57 3 108212 7 42513113
Victim of sexual abuse 11.34 10.57 3 108212 7 42513113
Eosinophilic fasciitis 11.31 10.57 6 108209 134 42512986
Ventricular hypoplasia 11.22 10.57 5 108210 75 42513045
Visual acuity reduced 11.18 10.57 17 108198 17533 42495587
Rash 11.17 10.57 582 107633 276372 42236748
Wrong technique in product usage process 11.16 10.57 63 108152 42572 42470548
Blood cholesterol increased 11.09 10.57 33 108182 26708 42486412
Respiratory distress 10.99 10.57 158 108057 41662 42471458
Progressive multifocal leukoencephalopathy 10.91 10.57 8 108207 11528 42501592
Gastric haemorrhage 10.74 10.57 54 108161 10461 42502659
Accidental death 10.72 10.57 24 108191 3059 42510061
Ichthyosis 10.67 10.57 6 108209 151 42512969
Mania 10.66 10.57 54 108161 10493 42502627
Shock 10.65 10.57 38 108177 29083 42484037
Blood urea increased 10.58 10.57 45 108170 32748 42480372

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1491.54 9.67 2391 377380 175020 110034508
Drug use disorder 1406.01 9.67 838 378933 17236 110192292
Drug dependence 1400.25 9.67 1248 378523 48772 110160756
Poisoning deliberate 1136.85 9.67 846 378925 25485 110184043
Toxicity to various agents 996.62 9.67 3765 376006 476790 109732738
Serotonin syndrome 962.31 9.67 1100 378671 58053 110151475
Coma 758.32 9.67 1412 378359 116457 110093071
Completed suicide 553.52 9.67 1961 377810 240420 109969108
Intentional overdose 502.91 9.67 1283 378488 131218 110078310
Withdrawal syndrome 482.51 9.67 567 379204 30813 110178715
Miosis 459.71 9.67 467 379304 21516 110188012
Overdose 403.65 9.67 1732 378039 232062 109977466
Drug hypersensitivity 403.30 9.67 2805 376966 451285 109758243
Bradypnoea 393.79 9.67 287 379484 8362 110201166
Intentional product misuse 356.01 9.67 1135 378636 131769 110077759
Off label use 336.66 9.67 3415 376356 1496770 108712758
Respiratory depression 314.39 9.67 464 379307 31537 110177991
Somnolence 314.22 9.67 1920 377851 295529 109913999
Vomiting 276.27 9.67 4524 375247 906151 109303377
Prescription form tampering 244.98 9.67 85 379686 436 110209092
Mydriasis 230.35 9.67 330 379441 21827 110187701
Confusional state 225.85 9.67 2532 377239 466148 109743380
Wheezing 221.13 9.67 1568 378203 253662 109955866
Drug withdrawal syndrome 218.93 9.67 435 379336 37619 110171909
Drug ineffective 214.41 9.67 3807 375964 1516733 108692795
Substance use disorder 212.09 9.67 186 379585 7104 110202424
Suicide attempt 206.81 9.67 802 378969 102592 110106936
Myelosuppression 202.51 9.67 39 379732 94301 110115227
Epilepsy 198.56 9.67 775 378996 99434 110110094
Lip dry 195.05 9.67 770 379001 99313 110110215
Nasal oedema 193.99 9.67 172 379599 6667 110202861
Febrile neutropenia 182.95 9.67 522 379249 316245 109893283
Poisoning 178.74 9.67 342 379429 28763 110180765
Joint range of motion decreased 159.25 9.67 833 378938 120999 110088529
Sensitisation 156.35 9.67 123 379648 4028 110205500
Asphyxia 155.59 9.67 217 379554 13998 110195530
Fibromyalgia 154.42 9.67 1061 378710 169848 110039680
Nail disorder 148.92 9.67 488 379283 57447 110152081
Blepharospasm 147.31 9.67 469 379302 54382 110155146
Drug detoxification 145.52 9.67 60 379711 528 110209000
Hepatocellular injury 145.23 9.67 443 379328 50199 110159329
Polycystic ovaries 144.83 9.67 125 379646 4671 110204857
Onychomadesis 143.85 9.67 413 379358 45250 110164278
Facet joint syndrome 142.03 9.67 684 379087 96144 110113384
Pyrexia 137.43 9.67 2214 377557 896051 109313477
Disease progression 132.32 9.67 414 379357 243620 109965908
Drug interaction 131.37 9.67 2430 377341 497753 109711775
Prescription drug used without a prescription 128.32 9.67 124 379647 5372 110204156
Taste disorder 126.52 9.67 502 379269 64885 110144643
Ejection fraction 125.41 9.67 94 379677 2861 110206667
COVID-19 120.38 9.67 434 379337 244626 109964902
Psoriatic arthropathy 119.92 9.67 1116 378655 195645 110013883
Generalised tonic-clonic seizure 119.14 9.67 436 379335 54244 110155284
Sleep disorder 117.73 9.67 1120 378651 197524 110012004
Dry mouth 116.85 9.67 1124 378647 198824 110010704
Drug resistance 115.43 9.67 26 379745 56348 110153180
Oedema 111.88 9.67 1158 378613 208818 110000710
Cardio-respiratory arrest 104.53 9.67 719 379052 115117 110094411
Onychomycosis 102.13 9.67 328 379443 38203 110171325
Breast cancer stage III 99.30 9.67 535 379236 78582 110130946
Myocardial infarction 99.15 9.67 333 379438 191750 110017778
Back injury 99.13 9.67 373 379398 47026 110162502
Type 2 diabetes mellitus 98.03 9.67 985 378786 176247 110033281
Cholestasis 96.95 9.67 459 379312 64059 110145469
Rheumatic fever 96.30 9.67 736 379035 121843 110087685
Live birth 94.18 9.67 480 379291 69004 110140524
Victim of chemical submission 93.38 9.67 50 379721 829 110208699
Death 92.51 9.67 3094 376677 695775 109513753
Peripheral venous disease 91.85 9.67 548 379223 83569 110125959
Neck pain 91.04 9.67 729 379042 122401 110087127
Finger deformity 89.81 9.67 284 379487 32808 110176720
Neutropenia 89.54 9.67 838 378933 373782 109835746
Product quality issue 89.21 9.67 511 379260 76788 110132740
Platelet count decreased 89.19 9.67 447 379324 229996 109979532
Anaemia 87.31 9.67 1337 378434 545749 109663779
Disorientation 86.07 9.67 474 379297 70197 110139331
Memory impairment 84.45 9.67 1041 378730 195903 110013625
Road traffic accident 83.33 9.67 643 379128 106755 110102773
Deafness transitory 83.22 9.67 50 379721 1043 110208485
Blood pressure increased 82.80 9.67 533 379238 257840 109951688
Asthma 82.44 9.67 1262 378509 249029 109960499
Cytomegalovirus infection 82.28 9.67 42 379729 54402 110155126
Analgesic drug level increased 80.99 9.67 83 379688 3863 110205665
Multiple organ dysfunction syndrome 80.36 9.67 260 379511 151450 110058078
Altered state of consciousness 79.44 9.67 400 379371 57226 110152302
Hallucination 78.54 9.67 607 379164 100825 110108703
Haemoglobin decreased 78.24 9.67 516 379255 248211 109961317
Rheumatoid arthritis 76.59 9.67 1450 378321 298163 109911365
Disease recurrence 76.49 9.67 58 379713 60726 110148802
Gastrooesophageal reflux disease 75.31 9.67 947 378824 179029 110030499
Hallucination, visual 74.96 9.67 302 379469 39303 110170225
Gastrointestinal pain 74.84 9.67 141 379630 11719 110197809
Night sweats 74.73 9.67 746 379025 133237 110076291
Depersonalisation/derealisation disorder 74.43 9.67 61 379710 2120 110207408
Drug withdrawal maintenance therapy 74.20 9.67 26 379745 138 110209390
Respiratory acidosis 73.53 9.67 153 379618 13673 110195855
Mobility decreased 72.84 9.67 1183 378588 236239 109973289
Product label confusion 71.32 9.67 205 379566 22472 110187056
Adverse reaction 70.49 9.67 243 379528 29351 110180177
Cardiac failure congestive 70.48 9.67 273 379498 150727 110058801
Inflammation 70.17 9.67 991 378780 192247 110017281
Gait inability 69.27 9.67 745 379026 135631 110073897
Agitation 69.24 9.67 642 379129 112409 110097119
Leukopenia 68.81 9.67 270 379501 148521 110061007
Hypoglycaemia 68.44 9.67 654 379117 115450 110094078
Folliculitis 68.37 9.67 878 378893 166775 110042753
Irritable bowel syndrome 68.24 9.67 863 378908 163352 110046176
C-reactive protein 67.89 9.67 244 379527 30087 110179441
Renal impairment 67.62 9.67 375 379396 188070 110021458
Injury 67.17 9.67 916 378855 176349 110033179
Blood creatinine increased 66.14 9.67 363 379408 182526 110027002
Fall 65.93 9.67 2615 377156 600867 109608661
Device expulsion 65.80 9.67 13 379758 30878 110178650
Derealisation 64.67 9.67 56 379715 2102 110207426
Osteoarthritis 63.70 9.67 930 378841 181693 110027835
Alanine aminotransferase increased 63.09 9.67 371 379400 183402 110026126
Wound infection 62.74 9.67 555 379216 95910 110113618
Erythema 62.11 9.67 670 379101 290777 109918751
Myoclonus 61.95 9.67 251 379520 32747 110176781
Septic shock 61.26 9.67 305 379466 157223 110052305
Hepatic function abnormal 60.93 9.67 135 379636 89160 110120368
Haematotoxicity 59.85 9.67 3 379768 21079 110188449
Sepsis 59.22 9.67 780 378991 326566 109882962
Bronchiectasis 58.44 9.67 26 379745 36467 110173061
White blood cell count decreased 58.32 9.67 505 379266 228885 109980643
Ill-defined disorder 57.18 9.67 805 378966 156048 110053480
Abdominal pain upper 56.89 9.67 1586 378185 347525 109862003
Seizure 56.69 9.67 1071 378700 220114 109989414
Lung disorder 55.91 9.67 899 378872 179148 110030380
Obstructive airways disorder 55.59 9.67 46 379725 46103 110163425
Minimum inhibitory concentration 54.47 9.67 21 379750 152 110209376
Drug diversion 54.38 9.67 42 379729 1338 110208190
Carpal tunnel syndrome 54.15 9.67 186 379585 22424 110187104
Insomnia 54.04 9.67 1621 378150 358969 109850559
Hypercholesterolaemia 53.70 9.67 512 379259 90325 110119203
C-reactive protein abnormal 53.63 9.67 681 379090 129014 110080514
Pancytopenia 53.49 9.67 461 379310 209152 110000376
Gastric pH decreased 53.40 9.67 37 379734 993 110208535
Mucosal inflammation 52.85 9.67 162 379609 95979 110113549
Aspartate aminotransferase increased 52.73 9.67 327 379444 159609 110049919
Wrong patient received product 51.98 9.67 87 379684 6587 110202941
Urinary retention 51.73 9.67 413 379358 69270 110140258
Cerebral infarction 51.70 9.67 61 379710 51777 110157751
Tonic clonic movements 51.57 9.67 57 379714 2895 110206633
Wrong technique in product usage process 51.06 9.67 143 379628 87205 110122323
Transplant rejection 50.96 9.67 11 379760 24556 110184972
Ejection fraction abnormal 50.67 9.67 61 379710 3399 110206129
Neutrophil count decreased 50.04 9.67 229 379542 120712 110088816
Antimicrobial susceptibility test resistant 49.83 9.67 26 379745 408 110209120
Nightmare 49.57 9.67 264 379507 38599 110170929
Hepatitis 49.53 9.67 500 379271 89554 110119974
Hyperhidrosis 49.06 9.67 910 378861 186388 110023140
Inappropriate schedule of product administration 48.83 9.67 455 379316 203182 110006346
Red blood cell sedimentation rate abnormal 48.80 9.67 12 379759 24497 110185031
Interstitial lung disease 48.50 9.67 280 379491 139054 110070474
Depressed level of consciousness 48.33 9.67 594 379177 111684 110097844
Haemophagocytic lymphohistiocytosis 48.20 9.67 24 379747 31535 110177993
Burning sensation 47.51 9.67 403 379368 68809 110140719
Thrombocytopenia 47.31 9.67 878 378893 348007 109861521
Loss of consciousness 47.07 9.67 941 378830 195365 110014163
Clonus 46.99 9.67 97 379674 8619 110200909
Drug dependence, antepartum 46.94 9.67 16 379755 77 110209451
Diabetes mellitus 46.80 9.67 179 379592 99202 110110326
Sciatica 46.56 9.67 504 379267 91895 110117633
Multiple drug therapy 46.56 9.67 92 379679 7922 110201606
Thrombotic microangiopathy 46.31 9.67 21 379750 29128 110180400
Condition aggravated 45.93 9.67 2059 377712 732777 109476751
Therapy partial responder 45.82 9.67 36 379735 37025 110172503
Pathogen resistance 45.81 9.67 4 379767 17668 110191860
Injection site pain 45.52 9.67 391 379380 177531 110031997
Respiratory tract infection 45.52 9.67 410 379361 71207 110138321
Housebound 45.47 9.67 25 379746 438 110209090
Acute myocardial infarction 45.46 9.67 142 379629 83635 110125893
Rhinitis allergic 45.19 9.67 150 379621 17772 110191756
Hyperacusis 44.81 9.67 53 379718 2899 110206629
Hypoaesthesia 44.78 9.67 1404 378367 312819 109896709
Aspergillus infection 44.70 9.67 16 379755 25600 110183928
Rheumatoid nodule 44.39 9.67 8 379763 20288 110189240
Pseudomonas infection 44.36 9.67 20 379751 27833 110181695
Hyperkalaemia 44.06 9.67 279 379492 135517 110074011
Shoulder arthroplasty 43.93 9.67 58 379713 3549 110205979
Drug dispensed to wrong patient 43.83 9.67 29 379742 720 110208808
Cytomegalovirus viraemia 43.50 9.67 5 379766 17759 110191769
Dependence 43.09 9.67 50 379721 2679 110206849
Depression 42.90 9.67 1409 378362 315926 109893602
Musculoskeletal pain 42.77 9.67 874 378897 182149 110027379
Nephrectomy 42.75 9.67 49 379722 2591 110206937
Bursitis 42.72 9.67 655 379116 129263 110080265
Muscle spasms 42.62 9.67 1254 378517 276903 109932625
Hallucinations, mixed 42.54 9.67 93 379678 8600 110200928
Grip strength decreased 42.11 9.67 441 379330 79733 110129795
Cough 41.58 9.67 1237 378534 460404 109749124
Sleep apnoea syndrome 41.30 9.67 259 379512 40188 110169340
Pneumocystis jirovecii pneumonia 40.82 9.67 52 379719 42683 110166845
Pleural effusion 40.51 9.67 402 379369 177307 110032221
Nephropathy toxic 40.33 9.67 22 379749 27456 110182072
Chest discomfort 40.16 9.67 392 379379 173456 110036072
Accidental overdose 40.01 9.67 310 379461 51524 110158004
Malaise 39.94 9.67 2748 377023 669071 109540457
Liver injury 39.80 9.67 732 379039 149681 110059847
Cardiac failure 39.68 9.67 432 379339 187194 110022334
Decorticate posture 39.50 9.67 21 379750 343 110209185
Angina pectoris 39.44 9.67 98 379673 62197 110147331
Inadequate analgesia 39.30 9.67 66 379705 5011 110204517
Behaviour disorder 39.27 9.67 96 379675 9551 110199977
Creatinine renal clearance decreased 39.15 9.67 13 379758 21802 110187726
Activated partial thromboplastin time prolonged 38.99 9.67 14 379757 22354 110187174
Ascites 38.83 9.67 175 379596 92633 110116895
Peripheral circulatory failure 38.68 9.67 39 379732 1780 110207748
Myasthenia gravis 38.29 9.67 13 379758 21498 110188030
Lymphopenia 38.24 9.67 49 379722 40121 110169407
Blood test abnormal 37.81 9.67 196 379575 28358 110181170
Epstein-Barr virus infection 37.65 9.67 9 379762 18729 110190799
Ulcer 37.63 9.67 56 379715 43060 110166468
Skin exfoliation 37.44 9.67 164 379607 87487 110122041
Acute generalised exanthematous pustulosis 36.93 9.67 160 379611 21504 110188024
Liver function test increased 36.62 9.67 465 379306 88083 110121445
Pulmonary embolism 36.62 9.67 517 379254 213957 109995571
Premature delivery 36.32 9.67 31 379740 30601 110178927
Blood glucose increased 36.25 9.67 286 379485 132210 110077318
Blood pressure systolic increased 36.23 9.67 154 379617 82837 110126691
Bacterial infection 36.23 9.67 64 379707 45972 110163556
Pulmonary alveolar haemorrhage 36.18 9.67 12 379759 20138 110189390
Hepatic enzyme 35.89 9.67 64 379707 5099 110204429
Therapeutic response decreased 35.72 9.67 190 379581 96309 110113219
Swollen tongue 35.56 9.67 340 379431 60022 110149506
Appendicitis 34.75 9.67 28 379743 28436 110181092
Colitis ulcerative 34.74 9.67 142 379629 77221 110132307
Functional gastrointestinal disorder 34.61 9.67 69 379702 5980 110203548
Visceral congestion 34.56 9.67 32 379739 1313 110208215
Obesity 34.44 9.67 564 379207 112787 110096741
Victim of sexual abuse 34.31 9.67 22 379749 517 110209011
Drug eruption 34.29 9.67 84 379687 53575 110155953
Dehydration 34.07 9.67 716 379055 278795 109930733
Rash 34.06 9.67 2394 377377 818570 109390958
Respiratory failure 34.02 9.67 527 379244 214805 109994723
Accidental exposure to product 33.79 9.67 76 379695 49932 110159596
Amnesia 33.72 9.67 529 379242 104879 110104649
Abortion spontaneous 33.49 9.67 41 379730 34241 110175287
Apnoea 33.36 9.67 113 379658 13526 110196002
Bladder cancer 33.22 9.67 14 379757 20278 110189250
Haematocrit decreased 33.16 9.67 116 379655 66001 110143527
Temperature regulation disorder 32.99 9.67 3 379768 12823 110196705
Analgesic drug level above therapeutic 32.96 9.67 21 379750 488 110209040
Bone marrow failure 32.86 9.67 96 379675 57752 110151776
Narcotic bowel syndrome 32.85 9.67 17 379754 262 110209266
Cytomegalovirus infection reactivation 32.77 9.67 11 379760 18322 110191206
Myocardial depression 32.67 9.67 24 379747 708 110208820
Immunodeficiency 32.40 9.67 52 379719 38786 110170742
Haemoptysis 32.02 9.67 131 379640 71223 110138305
Ankylosing spondylitis 31.93 9.67 122 379649 15490 110194038
Coronary artery disease 31.93 9.67 132 379639 71558 110137970
Blood calcium decreased 31.82 9.67 46 379725 35799 110173729
Faecaloma 31.74 9.67 118 379653 14790 110194738
Paraesthesia 31.71 9.67 1205 378566 275316 109934212
Wound 31.43 9.67 1040 378731 233397 109976131
Cryopyrin associated periodic syndrome 31.35 9.67 22 379749 603 110208925
Blood bilirubin increased 31.33 9.67 144 379627 75828 110133700
Blood parathyroid hormone decreased 31.27 9.67 4 379767 13085 110196443
Graft versus host disease 30.75 9.67 13 379758 18793 110190735
Eosinophil count increased 30.71 9.67 17 379754 21041 110188487
Impaired healing 30.71 9.67 889 378882 195828 110013700
Hypocholesterolaemia 30.63 9.67 68 379703 6353 110203175
Flushing 30.58 9.67 222 379549 104514 110105014
Myelodysplastic syndrome 30.51 9.67 51 379720 37433 110172095
Skin necrosis 30.46 9.67 18 379753 21494 110188034
Pancreatic fibrosis 30.20 9.67 12 379759 95 110209433
Sphincter of Oddi dysfunction 30.20 9.67 21 379750 567 110208961
Normal newborn 30.18 9.67 152 379619 21744 110187784
Eyelid myoclonus 29.99 9.67 13 379758 131 110209397
Euphoric mood 29.92 9.67 82 379689 8745 110200783
Suicidal ideation 29.88 9.67 471 379300 93466 110116062
Product complaint 29.51 9.67 6 379765 13966 110195562
Lung neoplasm malignant 29.49 9.67 44 379727 33798 110175730
Multiple-drug resistance 29.42 9.67 5 379766 13230 110196298
Injection site erythema 29.27 9.67 196 379575 93980 110115548
Sinus congestion 29.15 9.67 37 379734 30422 110179106
Duodenal ulcer perforation 29.11 9.67 808 378963 176892 110032636
BK virus infection 29.02 9.67 5 379766 13101 110196427
Blood pressure decreased 28.95 9.67 254 379517 114837 110094691
Feeling of despair 28.90 9.67 49 379722 3749 110205779
Coeliac disease 28.87 9.67 250 379521 42937 110166591
Abnormal loss of weight 28.72 9.67 89 379682 10168 110199360
Hepatotoxicity 28.70 9.67 116 379655 63284 110146244
Progressive multifocal leukoencephalopathy 28.69 9.67 26 379745 24930 110184598
Injection site swelling 28.64 9.67 112 379659 61678 110147850
Psychotic disorder due to a general medical condition 28.62 9.67 16 379755 290 110209238
Dysphonia 28.59 9.67 392 379379 75537 110133991
Substance dependence 28.43 9.67 22 379749 703 110208825
Mixed anxiety and depressive disorder 28.28 9.67 21 379750 630 110208898
Heart rate decreased 27.89 9.67 168 379603 82588 110126940
Frequent bowel movements 27.87 9.67 138 379633 71252 110138276
Breast disorder 27.86 9.67 37 379734 2277 110207251
Bronchopulmonary aspergillosis 27.84 9.67 37 379734 29826 110179702
Bradycardia foetal 27.42 9.67 12 379759 124 110209404
Hyperphosphataemia 27.30 9.67 11 379760 16370 110193158
Aplastic anaemia 27.15 9.67 26 379745 24282 110185246
Macular degeneration 26.83 9.67 21 379750 21638 110187890
Blood pressure fluctuation 26.77 9.67 149 379622 74675 110134853
Panniculitis 26.74 9.67 10 379761 15572 110193956
Respiratory symptom 26.66 9.67 9 379762 14936 110194592
Respiratory arrest 26.65 9.67 312 379459 57987 110151541
Rhinitis 26.51 9.67 23 379748 22522 110187006
Electric shock sensation 26.41 9.67 33 379738 1911 110207617
Sacroiliitis 26.37 9.67 55 379716 4923 110204605
Vasculitis 26.35 9.67 52 379719 35821 110173707
Coagulopathy 26.18 9.67 64 379707 40847 110168681
Female genital tract fistula 26.09 9.67 12 379759 16507 110193021
Nasal congestion 26.03 9.67 214 379557 98068 110111460
Arterial occlusive disease 25.98 9.67 10 379761 15298 110194230
Inappropriate antidiuretic hormone secretion 25.87 9.67 202 379569 33649 110175879
Eczema 25.84 9.67 144 379627 72149 110137379
Cestode infection 25.84 9.67 15 379756 293 110209235
Feeling of body temperature change 25.64 9.67 62 379709 6126 110203402
Throat irritation 25.51 9.67 96 379675 53456 110156072
Antidepressant drug level above therapeutic 25.47 9.67 21 379750 736 110208792
Productive cough 25.45 9.67 260 379511 114045 110095483
Poor venous access 25.38 9.67 28 379743 24494 110185034
Vaginal discharge 25.34 9.67 15 379756 17893 110191635
Rash erythematous 25.09 9.67 171 379600 81661 110127867
Basal cell carcinoma 25.08 9.67 76 379695 45194 110164334
Coma scale abnormal 25.05 9.67 82 379689 9644 110199884
Oedema peripheral 24.97 9.67 900 378871 327760 109881768
Enterococcal infection 24.90 9.67 20 379751 20346 110189182
Hyperlipasaemia 24.72 9.67 28 379743 1461 110208067
Therapeutic response delayed 24.56 9.67 27 379744 1363 110208165
Haemorrhage 24.46 9.67 241 379530 106451 110103077
H1N1 influenza 24.39 9.67 40 379731 2978 110206550
Substance abuse 24.36 9.67 96 379675 12367 110197161
Red blood cell sedimentation rate increased 24.32 9.67 163 379608 78139 110131389
Oesophageal carcinoma 24.23 9.67 5 379766 11519 110198009
Blood phosphorus increased 24.10 9.67 13 379758 16327 110193201
Aggression 24.08 9.67 310 379461 58900 110150628
Dysphagia 23.89 9.67 377 379394 153223 110056305
Arthritis 23.87 9.67 418 379353 167168 110042360
Ventricular fibrillation 23.87 9.67 68 379703 41245 110168283
Gastrointestinal haemorrhage 23.85 9.67 412 379359 165106 110044422
Feeling drunk 23.75 9.67 56 379715 5444 110204084
Swollen joint count increased 23.49 9.67 411 379360 83250 110126278
Haemodialysis 23.48 9.67 16 379755 17703 110191825
Oropharyngeal pain 23.47 9.67 325 379446 134951 110074577
Lymphadenopathy 23.45 9.67 126 379645 63709 110145819
Foetal death 23.33 9.67 13 379758 16032 110193496
Expired product administered 23.12 9.67 72 379699 8248 110201280
Somatic symptom disorder 23.04 9.67 40 379731 3119 110206409
Ventricular tachycardia 22.95 9.67 91 379680 49918 110159610
Weight decreased 22.95 9.67 1344 378427 466713 109742815
Haematochezia 22.84 9.67 270 379501 115254 110094274
Proctitis 22.81 9.67 15 379756 16912 110192616
Haematuria 22.78 9.67 179 379592 82826 110126702
Dissociation 22.73 9.67 80 379691 9762 110199766
Accidental exposure to product by child 22.69 9.67 40 379731 3158 110206370
Delirium 22.69 9.67 616 379155 134409 110075119
Dyspnoea exertional 22.64 9.67 238 379533 103822 110105706
Visual acuity reduced 22.47 9.67 48 379723 32125 110177403
Cyanosis 22.47 9.67 177 379594 29564 110179964
Sedation complication 22.46 9.67 21 379750 19834 110189694
Cytokine release syndrome 22.01 9.67 146 379625 70160 110139368
Neurologic neglect syndrome 21.84 9.67 3 379768 9295 110200233
Treatment failure 21.78 9.67 756 379015 276478 109933050
Congenital central hypoventilation syndrome 21.38 9.67 7 379764 29 110209499
Back disorder 21.37 9.67 134 379637 20788 110188740
Suicidal behaviour 21.36 9.67 41 379730 3456 110206072
Prothrombin time shortened 21.35 9.67 42 379729 3604 110205924
Diarrhoea 21.30 9.67 3514 376257 1135991 109073537
Colorectal cancer 21.26 9.67 3 379768 9111 110200417
Tonic convulsion 21.23 9.67 38 379733 3036 110206492
Bradycardia 21.17 9.67 391 379380 155126 110054402
Cushingoid 20.98 9.67 7 379764 11705 110197823
Menstrual disorder 20.98 9.67 49 379722 4735 110204793
Helicobacter infection 20.94 9.67 793 378978 181084 110028444
Discomfort 20.91 9.67 569 379202 214138 109995390
Hyperaesthesia 20.84 9.67 103 379668 14624 110194904
COVID-19 pneumonia 20.83 9.67 62 379709 37081 110172447
Graft versus host disease in gastrointestinal tract 20.81 9.67 3 379768 8965 110200563
Pituitary tumour benign 20.70 9.67 36 379735 2811 110206717
Cystitis haemorrhagic 20.68 9.67 8 379763 12201 110197327
Middle insomnia 20.58 9.67 24 379747 20478 110189050
Disturbance in attention 20.54 9.67 313 379458 61682 110147846
Drug level decreased 20.53 9.67 20 379751 18528 110191000
Cardiac murmur 20.52 9.67 33 379738 24595 110184933
Oral candidiasis 20.19 9.67 82 379689 44678 110164850
Rebound effect 20.12 9.67 13 379758 14793 110194735
Atelectasis 20.08 9.67 62 379709 36650 110172878
Orthostatic hypotension 20.03 9.67 139 379632 66110 110143418
Vascular encephalopathy 20.01 9.67 19 379752 805 110208723
Stomatitis 20.00 9.67 1127 378644 269115 109940413
Hypertonia 20.00 9.67 69 379702 8337 110201191
Tenosynovitis 19.90 9.67 16 379755 16267 110193261
Suspected suicide 19.90 9.67 104 379667 15095 110194433
Arteriovenous fistula 19.84 9.67 25 379746 1460 110208068
Pre-eclampsia 19.83 9.67 3 379768 8647 110200881
Pulmonary toxicity 19.80 9.67 19 379752 17727 110191801
Blood uric acid increased 19.74 9.67 27 379744 21502 110188026
Mucormycosis 19.67 9.67 6 379765 10622 110198906
Cerebrovascular accident 19.63 9.67 473 379298 180811 110028717
Malignant neoplasm progression 19.59 9.67 453 379318 174114 110035414
Body temperature increased 19.55 9.67 109 379662 54604 110154924
Psychomotor skills impaired 19.54 9.67 61 379710 6997 110202531
Neurological symptom 19.50 9.67 15 379756 15593 110193935
Hanging 19.45 9.67 11 379760 204 110209324
Pneumonia viral 19.42 9.67 7 379764 11150 110198378
Adrenergic syndrome 19.37 9.67 12 379759 265 110209263
Central nervous system stimulation 19.34 9.67 8 379763 71 110209457
Full blood count abnormal 19.31 9.67 113 379658 55939 110153589
Polyneuropathy in malignant disease 19.20 9.67 15 379756 486 110209042
Nausea 19.20 9.67 4651 375120 1231039 108978489
Infusion site reaction 19.17 9.67 115 379656 17567 110191961
Parasomnia 19.15 9.67 18 379753 753 110208775
Hypoxia 19.11 9.67 321 379450 129194 110080334
Stress 19.03 9.67 251 379520 105097 110104431
Migraine 18.95 9.67 745 379026 170907 110038621
Caesarean section 18.95 9.67 12 379759 13805 110195723
Muscle tone disorder 18.94 9.67 11 379760 215 110209313
Feeding disorder 18.91 9.67 132 379639 21230 110188298
Hypophosphataemia 18.89 9.67 55 379716 33127 110176401
Bladder prolapse 18.83 9.67 24 379747 1418 110208110
Tongue disorder 18.83 9.67 13 379758 14285 110195243
Dermatitis atopic 18.78 9.67 37 379734 25504 110184024
Allodynia 18.75 9.67 29 379742 2054 110207474
Respiratory rate increased 18.73 9.67 36 379735 25047 110184481
Ex-drug abuser 18.71 9.67 4 379767 0 110209528
Lactic acidosis 18.70 9.67 216 379555 92595 110116933
Chronic obstructive pulmonary disease 18.67 9.67 263 379508 108895 110100633
Hepatic cytolysis 18.65 9.67 279 379492 54774 110154754
Hypotension 18.61 9.67 1547 378224 522302 109687226
Transient ischaemic attack 18.49 9.67 136 379635 63846 110145682
Fear of injection 18.46 9.67 4 379767 8907 110200621
Accidental death 18.46 9.67 48 379723 4961 110204567
Listless 18.45 9.67 45 379726 4470 110205058
Neuroglycopenia 18.40 9.67 21 379750 1105 110208423
Disseminated intravascular coagulation 18.40 9.67 76 379695 41210 110168318
Postoperative delirium 18.33 9.67 19 379752 896 110208632
Syringe issue 18.32 9.67 5 379766 9520 110200008
Wrong rate 18.30 9.67 10 379761 173 110209355
Second primary malignancy 18.30 9.67 21 379750 18047 110191481
Acute motor-sensory axonal neuropathy 18.26 9.67 15 379756 523 110209005
Eosinophilic granulomatosis with polyangiitis 18.10 9.67 7 379764 10679 110198849
Drug dose omission by device 18.07 9.67 14 379757 14502 110195026
Renal failure 17.99 9.67 617 379154 225957 109983571
Radiculopathy 17.98 9.67 24 379747 19312 110190216
Skin toxicity 17.94 9.67 9 379762 11774 110197754
Herpes zoster 17.88 9.67 263 379508 108116 110101412
Chronic sinusitis 17.88 9.67 37 379734 25047 110184481
Metastases to liver 17.80 9.67 62 379709 35324 110174204
Immunosuppressant drug level increased 17.78 9.67 9 379762 11715 110197813
Hypernatraemia 17.77 9.67 21 379750 17812 110191716
Gas poisoning 17.76 9.67 8 379763 89 110209439
Therapeutic product ineffective 17.74 9.67 32 379739 2572 110206956
Chronic kidney disease 17.71 9.67 364 379407 75927 110133601
Encephalopathy 17.60 9.67 383 379388 80672 110128856
Muscle rigidity 17.60 9.67 142 379629 23889 110185639
Thrombosis 17.47 9.67 265 379506 108397 110101131
Cogwheel rigidity 17.46 9.67 39 379732 3659 110205869
Organising pneumonia 17.40 9.67 14 379757 14229 110195299
Immune reconstitution inflammatory syndrome 17.38 9.67 18 379753 16208 110193320
Nasal polyps 17.38 9.67 12 379759 13188 110196340
Allergy test negative 17.31 9.67 13 379758 397 110209131
Subileus 17.24 9.67 55 379716 6382 110203146
Glomerular filtration rate decreased 17.22 9.67 47 379724 28909 110180619
Restless legs syndrome 17.22 9.67 144 379627 24482 110185046
Cutaneous T-cell lymphoma stage I 17.20 9.67 9 379762 142 110209386
Tricuspid valve incompetence 17.19 9.67 35 379736 23838 110185690
Hyper IgE syndrome 17.11 9.67 16 379755 665 110208863
Heart rate increased 17.06 9.67 370 379401 143464 110066064
Disinhibition 17.04 9.67 35 379736 3099 110206429
Colitis 16.98 9.67 248 379523 102075 110107453
Hyperreflexia 16.90 9.67 71 379700 9414 110200114
Infection 16.86 9.67 1045 378726 361155 109848373
Lymphoma 16.83 9.67 27 379744 20144 110189384
Mood swings 16.82 9.67 135 379636 22677 110186851
Dizziness 16.79 9.67 2686 377085 695507 109514021
Premenstrual syndrome 16.71 9.67 15 379756 591 110208937
Bone lesion 16.71 9.67 58 379713 7029 110202499
Cardiovascular disorder 16.71 9.67 33 379738 22727 110186801
Acne 16.68 9.67 59 379712 33461 110176067
Escherichia bacteraemia 16.66 9.67 7 379764 10157 110199371
Hypercalcaemia 16.64 9.67 93 379678 46564 110162964
Gangrene 16.54 9.67 19 379752 16322 110193206
Hyperglycaemia 16.39 9.67 200 379571 84890 110124638
White blood cells urine positive 16.38 9.67 3 379768 7521 110202007
Cytopenia 16.37 9.67 51 379720 30065 110179463
Uveitis 16.35 9.67 31 379740 21679 110187849
Electrocution 16.27 9.67 5 379766 16 110209512
Infective pulmonary exacerbation of cystic fibrosis 16.27 9.67 16 379755 14755 110194773
Drug level below therapeutic 16.20 9.67 10 379761 11663 110197865
Pulmonary hypertension 16.14 9.67 117 379654 55103 110154425
Speech disorder 16.06 9.67 299 379472 61270 110148258
Haemolysis 16.03 9.67 18 379753 15621 110193907
Constipation 16.02 9.67 1432 378339 356354 109853174
Neuritis 16 9.67 3 379768 7396 110202132
Neutropenic colitis 15.96 9.67 4 379767 8061 110201467
Ocular hyperaemia 15.88 9.67 75 379696 39211 110170317
Tubulointerstitial nephritis 15.87 9.67 115 379656 54169 110155359
Hypertension 15.86 9.67 1992 377779 508092 109701436
Acute myeloid leukaemia 15.85 9.67 72 379699 38038 110171490
Catarrh 15.81 9.67 3 379768 7332 110202196
Oesophagitis chemical 15.77 9.67 7 379764 75 110209453
SARS-CoV-2 test positive 15.77 9.67 21 379750 16914 110192614
Swelling face 15.74 9.67 422 379349 91899 110117629
Influenza 15.73 9.67 451 379320 168650 110040878
Chemical poisoning 15.63 9.67 9 379762 173 110209355
Neuroleptic malignant syndrome 15.61 9.67 62 379709 33997 110175531
Drug screen positive 15.58 9.67 53 379718 6357 110203171
Substance abuser 15.57 9.67 13 379758 464 110209064
Vaccination site reaction 15.52 9.67 10 379761 237 110209291
Prothrombin time prolonged 15.47 9.67 22 379749 17239 110192289
Faecal disimpaction 15.41 9.67 5 379766 20 110209508
Vertigo 15.36 9.67 399 379372 86471 110123057
Urticaria 15.34 9.67 1283 378488 317574 109891954
Fracture 15.28 9.67 141 379630 24647 110184881
Thermal burn 15.18 9.67 61 379710 7927 110201601
Drug-induced liver injury 15.16 9.67 529 379242 119538 110089990
Akathisia 15.15 9.67 22 379749 17091 110192437
Drug screen false positive 15.13 9.67 21 379750 1348 110208180
Thrombotic thrombocytopenic purpura 15.13 9.67 3 379768 7108 110202420
Glossodynia 15.12 9.67 919 378852 221085 109988443
Mitral valve incompetence 15.07 9.67 61 379710 33268 110176260
Fear 15.06 9.67 36 379735 23157 110186371
Palpitations 14.96 9.67 424 379347 158788 110050740
Diabetic ketoacidosis 14.91 9.67 84 379687 41974 110167554
Drug effective for unapproved indication 14.86 9.67 16 379755 14151 110195377
Congenital muscle absence 14.85 9.67 5 379766 23 110209505
Device leakage 14.84 9.67 20 379751 16028 110193500
Anal haemorrhage 14.84 9.67 44 379727 4908 110204620
Rales 14.83 9.67 40 379731 24699 110184829
Influenza like illness 14.77 9.67 214 379557 88198 110121330
Therapeutic response shortened 14.77 9.67 52 379719 29531 110179997
Capillary fragility 14.71 9.67 10 379761 260 110209268
Livedo reticularis 14.71 9.67 47 379724 5459 110204069
Upper respiratory tract infection 14.68 9.67 341 379430 130987 110078541
Hyperthermia 14.67 9.67 124 379647 21148 110188380
Hyperbilirubinaemia 14.59 9.67 55 379716 30616 110178912
Sarcoidosis 14.59 9.67 13 379758 12566 110196962
Injection site reaction 14.58 9.67 405 379366 88665 110120863
Gastroenteritis 14.58 9.67 76 379695 38724 110170804
Puncture site haematoma 14.58 9.67 10 379761 264 110209264
Product used for unknown indication 14.51 9.67 25 379746 1938 110207590
Endophthalmitis 14.48 9.67 5 379766 8182 110201346
Systemic lupus erythematosus 14.48 9.67 1037 378734 253301 109956227
Hypothermia 14.44 9.67 146 379625 26156 110183372
Product use in unapproved indication 14.43 9.67 1331 378440 446046 109763482
Device ineffective 14.40 9.67 9 379762 202 110209326
Blood cholesterol decreased 14.38 9.67 30 379741 2686 110206842
Kidney transplant rejection 14.37 9.67 12 379759 11975 110197553
Skin fissures 14.32 9.67 40 379731 24418 110185110
Bacteraemia 14.31 9.67 86 379685 42304 110167224
Incorrect dose administered 14.28 9.67 260 379511 103381 110106147
Blood pressure inadequately controlled 14.28 9.67 58 379713 7575 110201953
Renal tubular necrosis 14.27 9.67 55 379716 30420 110179108
Clostridium test positive 14.22 9.67 10 379761 10883 110198645
Pleural mesothelioma 14.19 9.67 7 379764 97 110209431
Intraocular pressure increased 14.17 9.67 10 379761 10866 110198662
Subcutaneous drug absorption impaired 14.17 9.67 58 379713 7601 110201927
Hyperlipidaemia 14.16 9.67 69 379702 35779 110173749
Cardiomyopathy 14.15 9.67 63 379708 33462 110176066
Complications of transplanted kidney 14.14 9.67 4 379767 7438 110202090
Muscle injury 14.14 9.67 605 379166 140202 110069326
Brain abscess 14.12 9.67 3 379768 6771 110202757
Papilloedema 14.04 9.67 4 379767 7405 110202123
Eye irritation 14.03 9.67 63 379708 33389 110176139
Sinus bradycardia 13.94 9.67 53 379718 29430 110180098
Blood lactate dehydrogenase increased 13.91 9.67 92 379679 44242 110165286
Rhinovirus infection 13.89 9.67 12 379759 11777 110197751
Pneumothorax 13.89 9.67 68 379703 35217 110174311
Logorrhoea 13.87 9.67 43 379728 4914 110204614
Anaphylactic reaction 13.85 9.67 293 379478 114007 110095521
Fluid retention 13.82 9.67 234 379537 94073 110115455
Transcription medication error 13.81 9.67 14 379757 643 110208885
Cardio-respiratory distress 13.76 9.67 10 379761 290 110209238
Granulocytopenia 13.74 9.67 14 379757 12701 110196827
Product substitution 13.70 9.67 8 379763 158 110209370
Spinal operation 13.63 9.67 74 379697 10898 110198630
Human herpesvirus 6 infection 13.54 9.67 3 379768 6578 110202950
Impaired quality of life 13.53 9.67 55 379716 29962 110179566
Musculoskeletal disorder 13.51 9.67 128 379643 22536 110186992
Gastrointestinal ulcer haemorrhage 13.51 9.67 22 379749 1628 110207900
Magnesium deficiency 13.44 9.67 15 379756 770 110208758
Contraindicated product administered 13.42 9.67 706 379065 247561 109961967
Renal cancer 13.36 9.67 15 379756 13019 110196509
Post stroke epilepsy 13.36 9.67 5 379766 33 110209495
Incorrect product administration duration 13.36 9.67 118 379653 20380 110189148
Product dose omission issue 13.35 9.67 938 378833 320844 109888684
Polymenorrhoea 13.33 9.67 18 379753 1126 110208402
Unintentional medical device removal 13.31 9.67 7 379764 8916 110200612
Respiratory disorder 13.29 9.67 169 379602 71213 110138315
Ligament calcification 13.27 9.67 9 379762 233 110209295
Systemic candida 13.22 9.67 9 379762 9965 110199563
Gastric cancer 13.22 9.67 11 379760 10997 110198531
Burns second degree 13.21 9.67 5 379766 7728 110201800
Pneumonia aspiration 13.19 9.67 369 379402 80864 110128664
Lung infiltration 13.18 9.67 42 379729 24586 110184942
Hypogammaglobulinaemia 13.17 9.67 31 379740 20045 110189483
Pseudoporphyria 13.16 9.67 15 379756 788 110208740
Injection site mass 13.15 9.67 42 379729 24571 110184957
Brain herniation 13.15 9.67 7 379764 8856 110200672
Alcohol abuse 13.10 9.67 42 379729 4887 110204641
Tachycardia 13.06 9.67 925 378846 225720 109983808
Tachyarrhythmia 13.05 9.67 6 379765 8255 110201273
Pneumonia fungal 13.03 9.67 19 379752 14735 110194793
Chronic spontaneous urticaria 12.96 9.67 24 379747 1969 110207559
Pleural neoplasm 12.93 9.67 11 379760 403 110209125
Device related infection 12.91 9.67 81 379690 39438 110170090
Large intestine polyp 12.84 9.67 20 379751 15097 110194431
Peripheral swelling 12.83 9.67 1580 378191 402454 109807074
Quality of life decreased 12.80 9.67 88 379683 14081 110195447
Nodule 12.78 9.67 63 379708 32568 110176960
Pneumonia cytomegaloviral 12.73 9.67 4 379767 6950 110202578
Adjustment disorder 12.71 9.67 11 379760 10784 110198744
Mania 12.68 9.67 118 379653 20678 110188850
Foot deformity 12.63 9.67 106 379665 48374 110161154
Cholelithiasis 12.62 9.67 148 379623 63274 110146254
Liver function test abnormal 12.56 9.67 164 379607 68786 110140742
Ventricular extrasystoles 12.55 9.67 38 379733 22603 110186925
Pancreatitis acute 12.52 9.67 283 379488 59991 110149537
Manipulation 12.50 9.67 6 379765 78 110209450
Skin plaque 12.48 9.67 15 379756 12630 110196898
Intestinal perforation 12.45 9.67 34 379737 20910 110188618
Product administered to patient of inappropriate age 12.44 9.67 6 379765 8030 110201498
Acidosis 12.34 9.67 125 379646 22406 110187122
Euglycaemic diabetic ketoacidosis 12.33 9.67 13 379758 11610 110197918
Pneumatosis intestinalis 12.27 9.67 7 379764 8522 110201006
Breast cancer stage I 12.25 9.67 5 379766 7382 110202146
No adverse event 12.24 9.67 179 379592 73660 110135868
Pleuritic pain 12.20 9.67 23 379748 16117 110193411
Autoimmune haemolytic anaemia 12.16 9.67 11 379760 10556 110198972
Epigastric discomfort 12.13 9.67 8 379763 9007 110200521
Gallbladder cholesterolosis 12.12 9.67 13 379758 638 110208890
Enthesopathy 12.11 9.67 15 379756 12463 110197065
Acute kidney injury 12.10 9.67 1957 377814 633473 109576055
Drug tolerance decreased 12.08 9.67 51 379720 27489 110182039
Umbilical hernia 12.07 9.67 52 379719 6970 110202558
Knee operation 12.07 9.67 52 379719 6970 110202558
Bronchospasm 12.06 9.67 58 379713 30181 110179347
Device malfunction 12.05 9.67 46 379725 25512 110184016
Retinal haemorrhage 12.04 9.67 9 379762 9492 110200036
Metabolic disorder 12.02 9.67 11 379760 10499 110199029
Tuberculosis 12.02 9.67 27 379744 17747 110191781
Bronchopulmonary aspergillosis allergic 12.00 9.67 7 379764 8419 110201109
Therapeutic product effect incomplete 11.97 9.67 908 378863 222897 109986631
Pruritus 11.97 9.67 1783 377988 579777 109629751
Thecal sac compression 11.96 9.67 3 379768 3 110209525
Fungal infection 11.96 9.67 114 379657 50692 110158836
Confusion postoperative 11.95 9.67 10 379761 358 110209170
Central-alveolar hypoventilation 11.93 9.67 5 379766 46 110209482
Muscle disorder 11.93 9.67 50 379721 6622 110202906
Ear pruritus 11.90 9.67 5 379766 7255 110202273
Joint destruction 11.88 9.67 12 379759 10931 110198597
Labelled drug-drug interaction issue 11.87 9.67 36 379735 4065 110205463
Personality disorder 11.87 9.67 16 379755 12821 110196707
Underdose 11.85 9.67 294 379477 63260 110146268
General physical health deterioration 11.84 9.67 1650 378121 423645 109785883
Lymphoproliferative disorder 11.78 9.67 5 379766 7213 110202315
Oral herpes 11.76 9.67 74 379697 36006 110173522
Drug withdrawal convulsions 11.76 9.67 26 379745 2423 110207105
Laryngeal pain 11.75 9.67 3 379768 5972 110203556
Blood calcium increased 11.72 9.67 28 379743 18012 110191516
Complication of device insertion 11.68 9.67 8 379763 8830 110200698
Medication overuse headache 11.68 9.67 20 379751 1543 110207985
Cerebral haemorrhage 11.66 9.67 155 379616 64813 110144715
Hyponatraemia 11.64 9.67 883 378888 216770 109992758
Neuropathy peripheral 11.63 9.67 500 379271 178777 110030751
Carcinoembryonic antigen 11.62 9.67 6 379765 92 110209436
Purple glove syndrome 11.62 9.67 9 379762 288 110209240
Lichen sclerosus 11.56 9.67 17 379754 1151 110208377
Dermatitis bullous 11.55 9.67 27 379744 17502 110192026
Paraesthesia oral 11.53 9.67 68 379703 33603 110175925
Jaundice 11.50 9.67 139 379632 59097 110150431
Accidental poisoning 11.49 9.67 26 379745 2461 110207067
Glycosylated haemoglobin increased 11.47 9.67 42 379729 23577 110185951
Mycobacterium avium complex infection 11.46 9.67 3 379768 5874 110203654
Metastases to central nervous system 11.46 9.67 40 379731 22777 110186751
Hemiparesis 11.44 9.67 96 379675 43807 110165721
Toxic epidermal necrolysis 11.44 9.67 132 379639 56595 110152933
Cognitive disorder 11.41 9.67 387 379384 87124 110122404
Hemiplegia 11.40 9.67 40 379731 22742 110186786
Fibrosis 11.39 9.67 6 379765 7636 110201892
Negative pressure pulmonary oedema 11.36 9.67 13 379758 686 110208842
Normochromic normocytic anaemia 11.35 9.67 17 379754 13040 110196488
Lip pruritus 11.34 9.67 18 379753 1304 110208224
Diabetes mellitus inadequate control 11.32 9.67 154 379617 29621 110179907
Hepatobiliary disease 11.31 9.67 16 379755 1046 110208482
Surgery 11.30 9.67 202 379569 41081 110168447
Transfusion 11.28 9.67 47 379724 25425 110184103
Optic nerve operation 11.26 9.67 11 379760 483 110209045
Pericardial effusion 11.20 9.67 134 379637 57083 110152445
Secretion discharge 11.20 9.67 34 379737 20210 110189318
Deformity 11.19 9.67 11 379760 10149 110199379
Carbohydrate antigen 15-3 11.18 9.67 6 379765 100 110209428
Spleen congestion 11.17 9.67 11 379760 488 110209040
Extrapyramidal disorder 11.15 9.67 56 379715 28811 110180717
Pulmonary tuberculosis 11.14 9.67 9 379762 9130 110200398
Escherichia infection 11.14 9.67 43 379728 23773 110185755
Colon cancer 11.10 9.67 25 379746 16418 110193110
Hyperpyrexia 11.08 9.67 7 379764 8062 110201466
Neurosis 11.04 9.67 12 379759 598 110208930
Postmortem blood drug level increased 11.03 9.67 17 379754 1200 110208328
Hepatitis B reactivation 10.97 9.67 6 379765 7478 110202050
Eyelid ptosis 10.97 9.67 18 379753 13309 110196219
Rectal prolapse 10.96 9.67 26 379745 2537 110206991
Post procedural haemorrhage 10.95 9.67 23 379748 15489 110194039
Atrioventricular block complete 10.92 9.67 34 379737 20048 110189480
Acquired cystic kidney disease 10.92 9.67 5 379766 58 110209470
Complication associated with device 10.90 9.67 34 379737 20039 110189489
Encephalitis 10.89 9.67 31 379740 18808 110190720
Clostridial infection 10.89 9.67 4 379767 6298 110203230
Skin haemorrhage 10.88 9.67 46 379725 24781 110184747
Performance enhancing product use 10.86 9.67 7 379764 166 110209362
Pneumonitis 10.86 9.67 191 379580 76340 110133188
Oedematous pancreatitis 10.86 9.67 20 379751 1634 110207894
Lymphocyte count decreased 10.85 9.67 135 379636 57108 110152420
Brachial artery entrapment syndrome 10.84 9.67 5 379766 59 110209469
Arthrofibrosis 10.82 9.67 6 379765 107 110209421
Renal disorder 10.81 9.67 234 379537 49245 110160283
Blood cholesterol increased 10.79 9.67 755 379016 184030 110025498
Abscess 10.78 9.67 53 379718 27416 110182112
Atrial fibrillation 10.78 9.67 662 379109 228980 109980548
Granuloma 10.78 9.67 10 379761 9480 110200048
Staphylococcal infection 10.76 9.67 172 379599 69772 110139756
Thoracic radiculopathy 10.74 9.67 4 379767 26 110209502
Skin reaction 10.67 9.67 37 379734 21107 110188421
Therapeutic product effect decreased 10.66 9.67 709 379062 243607 109965921
Blood urea increased 10.65 9.67 129 379642 54828 110154700
Compulsive shopping 10.64 9.67 14 379757 854 110208674
Respiratory syncytial virus infection 10.63 9.67 21 379750 14463 110195065
Clostridium difficile infection 10.63 9.67 121 379650 52008 110157520
Fear of disease 10.62 9.67 18 379753 1377 110208151
Hyperthyroidism 10.61 9.67 58 379713 29203 110180325
SARS-CoV-2 test false positive 10.61 9.67 4 379767 27 110209501
Rash pruritic 10.58 9.67 256 379515 97813 110111715
Peritoneal perforation 10.57 9.67 7 379764 174 110209354
Muscle spasticity 10.54 9.67 76 379695 35839 110173689
Osteopenia 10.45 9.67 40 379731 22169 110187359
Emotional distress 10.40 9.67 101 379670 44746 110164782
Anterograde amnesia 10.39 9.67 14 379757 874 110208654
Adverse event 10.36 9.67 465 379306 108344 110101184
Neutrophil count increased 10.33 9.67 73 379698 34579 110174949
Gallbladder polyp 10.32 9.67 17 379754 1270 110208258
Nephrogenic systemic fibrosis 10.32 9.67 3 379768 5480 110204048
Incision site haematoma 10.30 9.67 7 379764 182 110209346
Confusional arousal 10.26 9.67 7 379764 183 110209345
Clonic convulsion 10.24 9.67 19 379752 1561 110207967
Gastrointestinal toxicity 10.20 9.67 14 379757 11134 110198394
Dyslipidaemia 10.19 9.67 25 379746 15940 110193588
Narcolepsy 10.17 9.67 19 379752 1569 110207959
Cardiac failure chronic 10.16 9.67 20 379751 13791 110195737
Cataract 10.15 9.67 202 379569 79283 110130245
Theft 10.14 9.67 8 379763 263 110209265
Respiratory depth decreased 10.14 9.67 4 379767 31 110209497
Post procedural complication 10.14 9.67 52 379719 26606 110182922
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.13 9.67 3 379768 5414 110204114
Breast cancer female 10.11 9.67 17 379754 12451 110197077
Pneumonia bacterial 10.11 9.67 51 379720 26210 110183318
Device difficult to use 10.11 9.67 32 379739 18773 110190755
Klebsiella infection 10.10 9.67 35 379736 19974 110189554
Skin hyperpigmentation 10.07 9.67 9 379762 8687 110200841
Diffuse large B-cell lymphoma 10.07 9.67 25 379746 15873 110193655
Bundle branch block left 10.07 9.67 18 379753 12870 110196658
International normalised ratio increased 10.06 9.67 224 379547 86548 110122980
Persistent genital arousal disorder 10.03 9.67 12 379759 664 110208864
Incorrect route of product administration 10.03 9.67 157 379614 63904 110145624
Unevaluable event 10.02 9.67 143 379628 59084 110150444
Anhedonia 9.98 9.67 24 379747 15404 110194124
Pulmonary mass 9.97 9.67 81 379690 37220 110172308
Skin ulcer 9.96 9.67 156 379615 63489 110146039
Renal injury 9.95 9.67 32 379739 18681 110190847
Ejection fraction decreased 9.94 9.67 91 379680 40789 110168739
Vascular purpura 9.90 9.67 32 379739 3739 110205789
Cytomegalovirus colitis 9.87 9.67 6 379765 7055 110202473
Coronary artery occlusion 9.84 9.67 25 379746 15747 110193781
Device use error 9.83 9.67 10 379761 9079 110200449
Haemorrhagic fever 9.82 9.67 4 379767 34 110209494
Sputum discoloured 9.80 9.67 56 379715 27889 110181639
Electrocardiogram QT interval 9.79 9.67 8 379763 277 110209251
Exposure via ingestion 9.78 9.67 38 379733 4862 110204666
Trigger finger 9.77 9.67 39 379732 5053 110204475
Post viral fatigue syndrome 9.76 9.67 8 379763 278 110209250
Pseudomonal sepsis 9.73 9.67 10 379761 9036 110200492
Thymus disorder 9.70 9.67 11 379760 575 110208953
Glaucoma 9.69 9.67 42 379729 22475 110187053
Gamma-glutamyltransferase increased 9.69 9.67 150 379621 61159 110148369

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02AJ13 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ14 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ15 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ16 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AX02 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Other opioids
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018689 Sensory System Agents
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35482 opioid analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35640 adrenergic uptake inhibitor
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:48279 serotonergic antagonist
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:48878 nicotinic antagonist
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:55322 μ-opioid receptor agonist
CHEBI has role CHEBI:59282 κ-opioid receptor agonist
CHEBI has role CHEBI:60643 NMDA receptor antagonist
CHEBI has role CHEBI:64054 δ-opioid receptor agonist
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:70774 capsaicin receptor antagonist
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

N02AJ Opioids in combination with non-opioid analgesics 9 drugs
acetylsalicylic acidcelecoxibcodeinedexketoprofendihydrocodeinehydrocodoneibuprofenoxycodoneparacetamol
N02AX Other opioids 6 drugs
dezocinemeptazinolnaloxoneoliceridinetapentadoltilidine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Chronic pain indication 82423001
Osteoarthritis indication 396275006
Fibromyalgia off-label use 203082005 DOID:631
Neuropathic pain off-label use 247398009
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Hypertensive disorder contraindication 38341003 DOID:10763
Hyperlipidemia contraindication 55822004 DOID:1168
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Poisoning by acetaminophen contraindication 70273001
Diabetes mellitus contraindication 73211009 DOID:9351
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Epilepsy contraindication 84757009 DOID:1826
Infectious disease of central nervous system contraindication 128117002
Seizure disorder contraindication 128613002
Alcohol withdrawal syndrome contraindication 191480000
Disease of liver contraindication 235856003 DOID:409
Poisoning by opiate analgesic drug contraindication 241749009
Suicidal contraindication 267073005
Pregnancy, function contraindication 289908002
Drug withdrawal contraindication 363101005
Serotonin syndrome contraindication 371089000
Central nervous system depression contraindication 418072004
Benzodiazepine Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.01 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 DISCN TABLET ORAL 10238668 April 19, 2030 A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 DISCN TABLET ORAL 10548909 April 19, 2030 A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 DISCN TABLET ORAL 11478488 April 19, 2030 A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB
5MG/ML QDOLO ROSEMONT N214044 Sept. 1, 2020 DISCN SOLUTION ORAL 11103452 Sept. 1, 2040 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE AN OPIOID ANALGESIC AND FOR WHICH ALTERNATIVE TREATMENTS ARE INADEQUATE
5MG/ML QDOLO ROSEMONT N214044 Sept. 1, 2020 DISCN SOLUTION ORAL 11752103 Sept. 1, 2040 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE AN OPIOID ANALGESIC AND FOR WHICH ALTERNATIVE TREATMENTS ARE INADEQUATE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST Ki 5.80 CHEMBL CHEMBL
Sodium-dependent serotonin transporter Transporter IC50 5.83 CHEMBL
Sodium-dependent noradrenaline transporter Transporter IC50 6.10 CHEMBL
Kappa-type opioid receptor GPCR Ki 7.85 CHEMBL
Delta-type opioid receptor GPCR Ki 8.03 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.28 WOMBAT-PK
Mu-type opioid receptor GPCR Ki 5.62 CHEMBL

External reference:

IDSource
4023985 VUID
N0000021990 NUI
D01355 KEGG_DRUG
36282-47-0 SECONDARY_CAS_RN
4020912 VANDF
4023985 VANDF
C0040610 UMLSCUI
CHEBI:9648 CHEBI
CHEMBL1237044 ChEMBL_ID
CHEMBL1237065 ChEMBL_ID
DB00193 DRUGBANK_ID
D014147 MESH_DESCRIPTOR_UI
33741 PUBCHEM_CID
8286 IUPHAR_LIGAND_ID
2722 INN_ID
39J1LGJ30J UNII
10689 RXNORM
44050 MMSL
5605 MMSL
d03826 MMSL
004180 NDDF
004181 NDDF
108505002 SNOMEDCT_US
108507005 SNOMEDCT_US
386858008 SNOMEDCT_US
39J1LGJ30J INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Tramadol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-3301 TABLET, FILM COATED 50 mg ORAL ANDA 29 sections
Tramadol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7496 TABLET, COATED 50 mg ORAL ANDA 30 sections
Tramadol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-009 TABLET 50 mg ORAL ANDA 17 sections
Tramadol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-531 TABLET 50 mg ORAL ANDA 16 sections
TRAMADOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 12634-786 TABLET 50 mg ORAL ANDA 16 sections
Tramadol HydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 13811-689 CAPSULE 100 mg ORAL NDA AUTHORIZED GENERIC 38 sections
Tramadol HydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 13811-690 CAPSULE 200 mg ORAL NDA AUTHORIZED GENERIC 38 sections
Tramadol HydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 13811-691 CAPSULE 300 mg ORAL NDA AUTHORIZED GENERIC 38 sections
Tramadol Hydrochloride Human Prescription Drug Label 1 16571-716 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Tramadol Hydrochloride Human Prescription Drug Label 1 16571-716 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
TRAMADOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-229 TABLET 50 mg ORAL ANDA 28 sections
Tramadol Hydrochloride and Acetaminophen HUMAN PRESCRIPTION DRUG LABEL 2 16590-230 TABLET, COATED 37.50 mg ORAL NDA 31 sections
RYZOLT HUMAN PRESCRIPTION DRUG LABEL 1 16590-244 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 12 sections
RYZOLT HUMAN PRESCRIPTION DRUG LABEL 1 16590-253 TABLET, EXTENDED RELEASE 100 mg ORAL NDA 12 sections
RYZOLT HUMAN PRESCRIPTION DRUG LABEL 1 16590-255 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 12 sections
Tramadol ER HUMAN PRESCRIPTION DRUG LABEL 1 16590-893 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 13 sections
Tramadol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-132 TABLET 50 mg ORAL ANDA 16 sections
ULTRACET HUMAN PRESCRIPTION DRUG LABEL 2 21695-143 TABLET 37.50 mg ORAL NDA 25 sections
Tramadol Hydrochloride and Acetaminophen HUMAN PRESCRIPTION DRUG LABEL 2 21695-236 TABLET 37.50 mg ORAL ANDA 27 sections
ULTRAM ER HUMAN PRESCRIPTION DRUG LABEL 1 21695-292 TABLET, EXTENDED RELEASE 100 mg ORAL NDA 26 sections
ULTRAM ER HUMAN PRESCRIPTION DRUG LABEL 1 21695-563 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 26 sections
TRAMADOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 21695-699 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 24 sections
TRAMADOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 21695-700 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 24 sections
ULTRAM ER HUMAN PRESCRIPTION DRUG LABEL 1 21695-913 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 26 sections
Tramadol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 24236-609 TABLET 50 mg ORAL ANDA 22 sections
TRAMADOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 27808-301 TABLET, FILM COATED 50 mg ORAL ANDA 32 sections
Tramadol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 29300-355 TABLET, FILM COATED 50 mg ORAL ANDA 21 sections
Tramadol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 29300-355 TABLET, FILM COATED 50 mg ORAL ANDA 21 sections
Tramadol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-105 TABLET, COATED 50 mg ORAL ANDA 14 sections
Tramadol Hydrochloride and Acetaminophen HUMAN PRESCRIPTION DRUG LABEL 2 33261-389 TABLET 37.50 mg ORAL ANDA 13 sections