Stem definition | Drug id | CAS RN |
---|---|---|
blood coagulation factor XA inhibitors, antithrombotics | 4182 | 366789-02-8 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
Property | Value | Reference |
---|---|---|
Vd (Volume of distribution) | 0.70 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.06 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 18, 2012 | PMDA | Bayer Yakuhin, Ltd. | |
July 1, 2011 | FDA | JANSSEN PHARMS | |
Sept. 30, 2008 | EMA | BAYER PHARMA AG |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Gastrointestinal haemorrhage | 5623.70 | 10.65 | 2938 | 110566 | 77392 | 53158170 |
Pulmonary embolism | 2348.79 | 10.65 | 1943 | 111561 | 112499 | 53123063 |
Deep vein thrombosis | 1929.36 | 10.65 | 1516 | 111988 | 81397 | 53154165 |
Ischaemic stroke | 1253.49 | 10.65 | 658 | 112846 | 17335 | 53218227 |
Haemorrhage | 1150.57 | 10.65 | 967 | 112537 | 57020 | 53178542 |
Cerebral haemorrhage | 1037.33 | 10.65 | 698 | 112806 | 29298 | 53206264 |
Cerebrovascular accident | 1013.11 | 10.65 | 1182 | 112322 | 103992 | 53131570 |
Epistaxis | 977.05 | 10.65 | 950 | 112554 | 67760 | 53167802 |
Haemorrhage intracranial | 805.80 | 10.65 | 444 | 113060 | 12908 | 53222654 |
Upper gastrointestinal haemorrhage | 805.05 | 10.65 | 487 | 113017 | 16943 | 53218619 |
Thrombosis | 801.88 | 10.65 | 807 | 112697 | 59986 | 53175576 |
Heavy menstrual bleeding | 689.92 | 10.65 | 441 | 113063 | 16935 | 53218627 |
Haematuria | 684.65 | 10.65 | 531 | 112973 | 27858 | 53207704 |
Rectal haemorrhage | 666.50 | 10.65 | 614 | 112890 | 40867 | 53194695 |
Vaginal haemorrhage | 612.59 | 10.65 | 486 | 113018 | 26355 | 53209207 |
Haematoma | 610.91 | 10.65 | 535 | 112969 | 33309 | 53202253 |
Haemoglobin decreased | 589.27 | 10.65 | 1051 | 112453 | 136256 | 53099306 |
Cerebral infarction | 556.53 | 10.65 | 442 | 113062 | 24002 | 53211560 |
Melaena | 508.75 | 10.65 | 452 | 113052 | 28677 | 53206885 |
Lower gastrointestinal haemorrhage | 499.27 | 10.65 | 267 | 113237 | 7299 | 53228263 |
Haemorrhagic stroke | 439.41 | 10.65 | 224 | 113280 | 5534 | 53230028 |
Anaemia | 436.31 | 10.65 | 1436 | 112068 | 275282 | 52960280 |
Embolic stroke | 433.98 | 10.65 | 195 | 113309 | 3604 | 53231958 |
Rheumatoid arthritis | 406.19 | 10.65 | 87 | 113417 | 314444 | 52921118 |
Atrial fibrillation | 364.93 | 10.65 | 762 | 112742 | 110890 | 53124672 |
Internal haemorrhage | 362.16 | 10.65 | 184 | 113320 | 4512 | 53231050 |
Subdural haematoma | 340.82 | 10.65 | 262 | 113242 | 13551 | 53222011 |
Haematochezia | 327.88 | 10.65 | 427 | 113077 | 41931 | 53193631 |
Atrial thrombosis | 270.76 | 10.65 | 107 | 113397 | 1412 | 53234150 |
Blood loss anaemia | 268.69 | 10.65 | 190 | 113314 | 8633 | 53226929 |
Incorrect dose administered | 258.46 | 10.65 | 421 | 113083 | 50624 | 53184938 |
Intraventricular haemorrhage | 238.21 | 10.65 | 106 | 113398 | 1912 | 53233650 |
Pericardial haemorrhage | 235.73 | 10.65 | 98 | 113406 | 1485 | 53234077 |
Pain | 234.69 | 10.65 | 571 | 112933 | 587827 | 52647735 |
Haemoptysis | 230.05 | 10.65 | 291 | 113213 | 27748 | 53207814 |
Haemarthrosis | 228.74 | 10.65 | 120 | 113384 | 3150 | 53232412 |
International normalised ratio increased | 208.80 | 10.65 | 369 | 113135 | 47392 | 53188170 |
Post procedural haemorrhage | 205.05 | 10.65 | 155 | 113349 | 7813 | 53227749 |
Haematemesis | 203.71 | 10.65 | 288 | 113216 | 30569 | 53204993 |
Diverticulum intestinal haemorrhagic | 198.97 | 10.65 | 82 | 113422 | 1214 | 53234348 |
Haemorrhoidal haemorrhage | 198.81 | 10.65 | 117 | 113387 | 3861 | 53231701 |
Faeces discoloured | 197.49 | 10.65 | 215 | 113289 | 17471 | 53218091 |
Infusion related reaction | 197.27 | 10.65 | 45 | 113459 | 155912 | 53079650 |
Shock haemorrhagic | 193.98 | 10.65 | 159 | 113345 | 9024 | 53226538 |
Synovitis | 191.62 | 10.65 | 9 | 113495 | 107884 | 53127678 |
Haemorrhagic arteriovenous malformation | 186.74 | 10.65 | 47 | 113457 | 107 | 53235455 |
Fall | 172.09 | 10.65 | 1327 | 112177 | 357113 | 52878449 |
Therapeutic product effect decreased | 167.66 | 10.65 | 32 | 113472 | 125623 | 53109939 |
Systemic lupus erythematosus | 167.20 | 10.65 | 32 | 113472 | 125382 | 53110180 |
Transient ischaemic attack | 166.55 | 10.65 | 284 | 113220 | 35441 | 53200121 |
Hand deformity | 165.37 | 10.65 | 3 | 113501 | 84846 | 53150716 |
Gingival bleeding | 161.32 | 10.65 | 163 | 113341 | 12145 | 53223417 |
Glossodynia | 158.73 | 10.65 | 15 | 113489 | 100276 | 53135286 |
Subarachnoid haemorrhage | 156.78 | 10.65 | 158 | 113346 | 11735 | 53223827 |
Drug intolerance | 156.12 | 10.65 | 125 | 113379 | 205368 | 53030194 |
Labelled drug-drug interaction medication error | 155.18 | 10.65 | 151 | 113353 | 10748 | 53224814 |
Basal ganglia haemorrhage | 154.46 | 10.65 | 56 | 113448 | 573 | 53234989 |
Drug hypersensitivity | 148.28 | 10.65 | 209 | 113295 | 265033 | 52970529 |
Uterine haemorrhage | 145.22 | 10.65 | 95 | 113409 | 3792 | 53231770 |
Maternal exposure during pregnancy | 145.05 | 10.65 | 75 | 113429 | 155564 | 53079998 |
Hemiplegia | 144.05 | 10.65 | 125 | 113379 | 7675 | 53227887 |
Blood urine present | 140.54 | 10.65 | 157 | 113347 | 13128 | 53222434 |
Cerebral haematoma | 138.95 | 10.65 | 89 | 113415 | 3425 | 53232137 |
Creatinine renal clearance decreased | 135.84 | 10.65 | 139 | 113365 | 10512 | 53225050 |
Joint swelling | 133.00 | 10.65 | 183 | 113321 | 234455 | 53001107 |
Arthralgia | 132.87 | 10.65 | 485 | 113019 | 439298 | 52796264 |
Embolic cerebral infarction | 130.15 | 10.65 | 47 | 113457 | 475 | 53235087 |
Cerebellar haemorrhage | 129.94 | 10.65 | 63 | 113441 | 1392 | 53234170 |
Subcutaneous haematoma | 127.94 | 10.65 | 65 | 113439 | 1593 | 53233969 |
Abdominal wall haematoma | 126.21 | 10.65 | 79 | 113425 | 2919 | 53232643 |
Toxicity to various agents | 122.72 | 10.65 | 173 | 113331 | 219425 | 53016137 |
Muscle haemorrhage | 114.26 | 10.65 | 78 | 113426 | 3345 | 53232217 |
Haemorrhagic transformation stroke | 113.44 | 10.65 | 54 | 113450 | 1144 | 53234418 |
Hemiparesis | 112.57 | 10.65 | 180 | 113324 | 21295 | 53214267 |
Arthropathy | 111.25 | 10.65 | 83 | 113421 | 141370 | 53094192 |
Pyrexia | 111.24 | 10.65 | 461 | 113043 | 402732 | 52832830 |
Dyspnoea exertional | 110.18 | 10.65 | 311 | 113193 | 54689 | 53180873 |
Mouth haemorrhage | 110.05 | 10.65 | 100 | 113404 | 6526 | 53229036 |
Anxiety | 106.90 | 10.65 | 158 | 113346 | 196546 | 53039016 |
Thalamus haemorrhage | 106.89 | 10.65 | 43 | 113461 | 596 | 53234966 |
Iron deficiency anaemia | 106.10 | 10.65 | 162 | 113342 | 18418 | 53217144 |
Hypersensitivity | 104.31 | 10.65 | 180 | 113324 | 210485 | 53025077 |
Gastrointestinal vascular malformation haemorrhagic | 102.22 | 10.65 | 30 | 113474 | 144 | 53235418 |
Depression | 99.49 | 10.65 | 147 | 113357 | 182905 | 53052657 |
Subdural haemorrhage | 96.68 | 10.65 | 67 | 113437 | 2945 | 53232617 |
Drug interaction | 88.83 | 10.65 | 782 | 112722 | 218547 | 53017015 |
Musculoskeletal stiffness | 88.77 | 10.65 | 79 | 113425 | 123289 | 53112273 |
Prothrombin time prolonged | 88.68 | 10.65 | 107 | 113397 | 9715 | 53225847 |
Injection site erythema | 88.67 | 10.65 | 27 | 113477 | 77222 | 53158340 |
Dyspnoea | 87.99 | 10.65 | 1741 | 111763 | 584491 | 52651071 |
Cardiac failure | 87.94 | 10.65 | 389 | 113115 | 85455 | 53150107 |
Discomfort | 87.44 | 10.65 | 47 | 113457 | 95425 | 53140137 |
Drug abuse | 86.71 | 10.65 | 17 | 113487 | 65509 | 53170053 |
Contraindicated product administered | 85.97 | 10.65 | 97 | 113407 | 135532 | 53100030 |
Retroperitoneal haemorrhage | 85.06 | 10.65 | 61 | 113443 | 2833 | 53232729 |
Gastric ulcer haemorrhage | 84.99 | 10.65 | 77 | 113427 | 5005 | 53230557 |
Hospitalisation | 84.60 | 10.65 | 337 | 113167 | 70675 | 53164887 |
Alopecia | 84.41 | 10.65 | 239 | 113265 | 234344 | 53001218 |
Sinusitis | 84.36 | 10.65 | 143 | 113361 | 168421 | 53067141 |
Duodenal ulcer haemorrhage | 84.36 | 10.65 | 57 | 113447 | 2403 | 53233159 |
Eye haemorrhage | 82.83 | 10.65 | 92 | 113412 | 7642 | 53227920 |
Infection | 79.10 | 10.65 | 154 | 113350 | 172051 | 53063511 |
Extradural haematoma | 79.01 | 10.65 | 48 | 113456 | 1680 | 53233882 |
Cerebral artery embolism | 78.90 | 10.65 | 38 | 113466 | 827 | 53234735 |
Embolism venous | 78.63 | 10.65 | 59 | 113445 | 2940 | 53232622 |
Condition aggravated | 78.60 | 10.65 | 345 | 113159 | 296789 | 52938773 |
Embolism | 78.21 | 10.65 | 88 | 113416 | 7415 | 53228147 |
Wound haemorrhage | 77.75 | 10.65 | 52 | 113452 | 2155 | 53233407 |
Splenic rupture | 77.54 | 10.65 | 43 | 113461 | 1264 | 53234298 |
Post procedural haematoma | 77.23 | 10.65 | 44 | 113460 | 1364 | 53234198 |
Injection site pain | 76.43 | 10.65 | 77 | 113427 | 113314 | 53122248 |
Exposure during pregnancy | 76.23 | 10.65 | 92 | 113412 | 124768 | 53110794 |
Small intestinal haemorrhage | 74.99 | 10.65 | 50 | 113454 | 2061 | 53233501 |
Pulmonary thrombosis | 74.90 | 10.65 | 89 | 113415 | 7952 | 53227610 |
Haemorrhage urinary tract | 74.56 | 10.65 | 36 | 113468 | 788 | 53234774 |
Cerebral artery occlusion | 74.11 | 10.65 | 38 | 113466 | 950 | 53234612 |
Swelling | 73.79 | 10.65 | 188 | 113316 | 190917 | 53044645 |
Postmenopausal haemorrhage | 73.39 | 10.65 | 50 | 113454 | 2137 | 53233425 |
Renal haemorrhage | 73.21 | 10.65 | 36 | 113468 | 821 | 53234741 |
Treatment failure | 72.82 | 10.65 | 100 | 113404 | 128303 | 53107259 |
Venous thrombosis | 72.37 | 10.65 | 70 | 113434 | 4944 | 53230618 |
Product prescribing issue | 71.49 | 10.65 | 40 | 113464 | 1197 | 53234365 |
Rheumatoid factor positive | 71.33 | 10.65 | 4 | 113500 | 41194 | 53194368 |
Injection site reaction | 70.44 | 10.65 | 12 | 113492 | 51154 | 53184408 |
Gastric haemorrhage | 70.39 | 10.65 | 76 | 113428 | 6115 | 53229447 |
Peripheral embolism | 70.07 | 10.65 | 40 | 113464 | 1245 | 53234317 |
Wound | 69.07 | 10.65 | 56 | 113448 | 91501 | 53144061 |
Completed suicide | 68.44 | 10.65 | 118 | 113386 | 138083 | 53097479 |
Haemorrhage subcutaneous | 68.40 | 10.65 | 55 | 113449 | 3036 | 53232526 |
Febrile neutropenia | 67.64 | 10.65 | 74 | 113430 | 104862 | 53130700 |
Product prescribing error | 66.87 | 10.65 | 150 | 113354 | 22881 | 53212681 |
Activated partial thromboplastin time prolonged | 65.54 | 10.65 | 78 | 113426 | 6981 | 53228581 |
Abnormal uterine bleeding | 64.97 | 10.65 | 39 | 113465 | 1335 | 53234227 |
Cerebral ventricular rupture | 64.80 | 10.65 | 22 | 113482 | 182 | 53235380 |
Cerebral ischaemia | 64.12 | 10.65 | 75 | 113429 | 6590 | 53228972 |
Pericarditis | 63.05 | 10.65 | 29 | 113475 | 64377 | 53171185 |
Pulmonary arterial hypertension | 62.98 | 10.65 | 162 | 113342 | 26960 | 53208602 |
Weight increased | 60.66 | 10.65 | 227 | 113277 | 204340 | 53031222 |
Treatment noncompliance | 60.56 | 10.65 | 181 | 113323 | 32854 | 53202708 |
Gastritis haemorrhagic | 59.70 | 10.65 | 38 | 113466 | 1446 | 53234116 |
Contusion | 59.15 | 10.65 | 421 | 113083 | 110311 | 53125251 |
Haemothorax | 58.58 | 10.65 | 43 | 113461 | 2071 | 53233491 |
Renal impairment | 57.52 | 10.65 | 338 | 113166 | 82980 | 53152582 |
Venous thrombosis limb | 56.04 | 10.65 | 48 | 113456 | 2895 | 53232667 |
Traumatic intracranial haemorrhage | 56.02 | 10.65 | 23 | 113481 | 337 | 53235225 |
Coagulopathy | 55.74 | 10.65 | 127 | 113377 | 19571 | 53215991 |
Gastric ulcer | 55.73 | 10.65 | 141 | 113363 | 23228 | 53212334 |
Therapeutic response decreased | 55.73 | 10.65 | 16 | 113488 | 47553 | 53188009 |
Incision site haemorrhage | 55.66 | 10.65 | 26 | 113478 | 527 | 53235035 |
Psoriatic arthropathy | 55.01 | 10.65 | 17 | 113487 | 48173 | 53187389 |
Transfusion | 55.01 | 10.65 | 102 | 113402 | 13585 | 53221977 |
Occult blood positive | 54.75 | 10.65 | 52 | 113452 | 3590 | 53231972 |
Pulmonary hypertension | 54.51 | 10.65 | 189 | 113315 | 37081 | 53198481 |
Anaphylactic reaction | 54.45 | 10.65 | 28 | 113476 | 58298 | 53177264 |
Therapeutic product effect incomplete | 53.53 | 10.65 | 70 | 113434 | 91714 | 53143848 |
Acute kidney injury | 53.50 | 10.65 | 797 | 112707 | 253071 | 52982491 |
Mobility decreased | 53.47 | 10.65 | 50 | 113454 | 76221 | 53159341 |
Haematoma muscle | 53.09 | 10.65 | 27 | 113477 | 663 | 53234899 |
Brain stem haemorrhage | 52.82 | 10.65 | 28 | 113476 | 751 | 53234811 |
Nasopharyngitis | 52.80 | 10.65 | 220 | 113284 | 192075 | 53043487 |
Pericardial effusion | 52.42 | 10.65 | 152 | 113352 | 27126 | 53208436 |
Intracardiac thrombus | 52.36 | 10.65 | 43 | 113461 | 2446 | 53233116 |
Loss of personal independence in daily activities | 52.28 | 10.65 | 43 | 113461 | 69772 | 53165790 |
Folliculitis | 52.18 | 10.65 | 4 | 113500 | 31705 | 53203857 |
Hepatic enzyme increased | 51.95 | 10.65 | 120 | 113384 | 126075 | 53109487 |
Splenic haemorrhage | 51.75 | 10.65 | 19 | 113485 | 202 | 53235360 |
Pregnancy | 51.64 | 10.65 | 4 | 113500 | 31437 | 53204125 |
Spinal cord haematoma | 51.40 | 10.65 | 18 | 113486 | 165 | 53235397 |
Adrenal haemorrhage | 51.22 | 10.65 | 23 | 113481 | 424 | 53235138 |
Anticoagulation drug level increased | 50.78 | 10.65 | 19 | 113485 | 214 | 53235348 |
Psoriasis | 50.20 | 10.65 | 67 | 113437 | 87022 | 53148540 |
Neutropenia | 49.59 | 10.65 | 173 | 113331 | 159012 | 53076550 |
Suicidal ideation | 49.51 | 10.65 | 34 | 113470 | 60477 | 53175085 |
Stomatitis | 49.32 | 10.65 | 83 | 113421 | 98075 | 53137487 |
Urinary bladder haemorrhage | 49.17 | 10.65 | 30 | 113474 | 1058 | 53234504 |
Multiple sclerosis relapse | 49.13 | 10.65 | 17 | 113487 | 44836 | 53190726 |
Pharyngeal haemorrhage | 48.94 | 10.65 | 24 | 113480 | 544 | 53235018 |
Cardioversion | 48.65 | 10.65 | 31 | 113473 | 1182 | 53234380 |
Muscle injury | 48.30 | 10.65 | 4 | 113500 | 29762 | 53205800 |
Cerebellar infarction | 48.18 | 10.65 | 37 | 113467 | 1909 | 53233653 |
Sedation | 48.12 | 10.65 | 4 | 113500 | 29671 | 53205891 |
Prothrombin time shortened | 48.08 | 10.65 | 36 | 113468 | 1788 | 53233774 |
Impaired healing | 47.52 | 10.65 | 40 | 113464 | 64165 | 53171397 |
Retinal haemorrhage | 47.07 | 10.65 | 56 | 113448 | 5009 | 53230553 |
Abdominal discomfort | 46.32 | 10.65 | 278 | 113226 | 220784 | 53014778 |
Pulmonary haemorrhage | 46.16 | 10.65 | 65 | 113439 | 6868 | 53228694 |
Large intestinal haemorrhage | 45.22 | 10.65 | 30 | 113474 | 1226 | 53234336 |
Seizure | 45.03 | 10.65 | 134 | 113370 | 129375 | 53106187 |
Microcytic anaemia | 44.66 | 10.65 | 45 | 113459 | 3340 | 53232222 |
Blood cholesterol increased | 44.39 | 10.65 | 29 | 113475 | 52960 | 53182602 |
Dizziness | 44.25 | 10.65 | 1070 | 112434 | 371189 | 52864373 |
Hypovolaemic shock | 44.17 | 10.65 | 57 | 113447 | 5540 | 53230022 |
Ecchymosis | 43.71 | 10.65 | 82 | 113422 | 11017 | 53224545 |
Injection site pruritus | 43.46 | 10.65 | 17 | 113487 | 41572 | 53193990 |
Spontaneous haematoma | 43.11 | 10.65 | 25 | 113479 | 802 | 53234760 |
Intra-abdominal haemorrhage | 42.95 | 10.65 | 38 | 113466 | 2394 | 53233168 |
Oedema peripheral | 42.34 | 10.65 | 552 | 112952 | 170235 | 53065327 |
Irritable bowel syndrome | 42.15 | 10.65 | 20 | 113484 | 43612 | 53191950 |
Inflammation | 41.79 | 10.65 | 36 | 113468 | 57100 | 53178462 |
Skin haemorrhage | 41.48 | 10.65 | 61 | 113443 | 6706 | 53228856 |
Glomerular filtration rate decreased | 41.45 | 10.65 | 87 | 113417 | 12680 | 53222882 |
Head injury | 41.31 | 10.65 | 135 | 113369 | 25698 | 53209864 |
Retroperitoneal haematoma | 41.30 | 10.65 | 40 | 113464 | 2830 | 53232732 |
Procedural haemorrhage | 41.16 | 10.65 | 38 | 113466 | 2531 | 53233031 |
Cerebral mass effect | 40.84 | 10.65 | 25 | 113479 | 887 | 53234675 |
Fatigue | 40.56 | 10.65 | 1215 | 112289 | 729291 | 52506271 |
Agitation | 40.42 | 10.65 | 39 | 113465 | 58587 | 53176975 |
Vascular pseudoaneurysm | 40.17 | 10.65 | 30 | 113474 | 1484 | 53234078 |
Salpingo-oophorectomy unilateral | 39.75 | 10.65 | 22 | 113482 | 644 | 53234918 |
Insomnia | 39.31 | 10.65 | 235 | 113269 | 186837 | 53048725 |
Blister | 39.19 | 10.65 | 67 | 113437 | 78686 | 53156876 |
Injection site swelling | 38.99 | 10.65 | 21 | 113483 | 42607 | 53192955 |
Drug ineffective | 38.81 | 10.65 | 1387 | 112117 | 815858 | 52419704 |
Suicide attempt | 38.61 | 10.65 | 40 | 113464 | 58128 | 53177434 |
Device related thrombosis | 38.60 | 10.65 | 28 | 113476 | 1324 | 53234238 |
Foetal exposure during pregnancy | 38.29 | 10.65 | 13 | 113491 | 34702 | 53200860 |
Cardiac failure chronic | 38.19 | 10.65 | 45 | 113459 | 3985 | 53231577 |
Hypertension | 38.07 | 10.65 | 302 | 113202 | 225129 | 53010433 |
Labelled drug-disease interaction medication error | 37.95 | 10.65 | 14 | 113490 | 151 | 53235411 |
Conjunctival haemorrhage | 37.19 | 10.65 | 40 | 113464 | 3204 | 53232358 |
Pelvic venous thrombosis | 36.34 | 10.65 | 29 | 113475 | 1583 | 53233979 |
Rash | 36.33 | 10.65 | 700 | 112804 | 445491 | 52790071 |
High frequency ablation | 36.25 | 10.65 | 14 | 113490 | 173 | 53235389 |
Traumatic haematoma | 36.15 | 10.65 | 28 | 113476 | 1463 | 53234099 |
Coagulation factor X level increased | 36.09 | 10.65 | 7 | 113497 | 0 | 53235562 |
Herpes zoster | 35.89 | 10.65 | 64 | 113440 | 73955 | 53161607 |
Retinal artery occlusion | 35.86 | 10.65 | 29 | 113475 | 1614 | 53233948 |
Fluid retention | 35.81 | 10.65 | 218 | 113286 | 54183 | 53181379 |
Intra-abdominal haematoma | 35.21 | 10.65 | 29 | 113475 | 1656 | 53233906 |
Subgaleal haematoma | 35.03 | 10.65 | 11 | 113493 | 69 | 53235493 |
Alanine aminotransferase increased | 34.06 | 10.65 | 97 | 113407 | 94998 | 53140564 |
Haemorrhagic cerebral infarction | 33.98 | 10.65 | 20 | 113484 | 660 | 53234902 |
Ill-defined disorder | 33.96 | 10.65 | 33 | 113471 | 49411 | 53186151 |
Product monitoring error | 33.50 | 10.65 | 36 | 113468 | 2881 | 53232681 |
Hepatotoxicity | 33.36 | 10.65 | 9 | 113495 | 27871 | 53207691 |
Sinusitis fungal | 33.35 | 10.65 | 26 | 113478 | 1372 | 53234190 |
Gastrointestinal angiodysplasia | 33.12 | 10.65 | 17 | 113487 | 426 | 53235136 |
Pulmonary alveolar haemorrhage | 33.07 | 10.65 | 44 | 113460 | 4406 | 53231156 |
Pallor | 32.82 | 10.65 | 123 | 113381 | 25059 | 53210503 |
Intentional overdose | 32.68 | 10.65 | 58 | 113446 | 67147 | 53168415 |
Anovulatory cycle | 32.24 | 10.65 | 12 | 113492 | 133 | 53235429 |
Gastrointestinal ulcer haemorrhage | 32.14 | 10.65 | 19 | 113485 | 632 | 53234930 |
Gastrointestinal disorder | 32.09 | 10.65 | 92 | 113412 | 89912 | 53145650 |
Duodenal ulcer | 32.06 | 10.65 | 58 | 113446 | 7578 | 53227984 |
Helicobacter infection | 31.90 | 10.65 | 22 | 113482 | 39047 | 53196515 |
Aphasia | 31.89 | 10.65 | 140 | 113364 | 30638 | 53204924 |
Peripheral ischaemia | 31.82 | 10.65 | 45 | 113459 | 4774 | 53230788 |
Abdominal wall haemorrhage | 31.77 | 10.65 | 12 | 113492 | 139 | 53235423 |
Mesenteric artery embolism | 31.76 | 10.65 | 7 | 113497 | 6 | 53235556 |
Traumatic haemorrhage | 31.31 | 10.65 | 17 | 113487 | 479 | 53235083 |
Emotional distress | 30.93 | 10.65 | 15 | 113489 | 32302 | 53203260 |
Gastritis erosive | 30.77 | 10.65 | 48 | 113456 | 5558 | 53230004 |
Chills | 30.62 | 10.65 | 117 | 113387 | 104731 | 53130831 |
Somnolence | 30.53 | 10.65 | 220 | 113284 | 167514 | 53068048 |
Ischaemic cerebral infarction | 30.46 | 10.65 | 24 | 113480 | 1286 | 53234276 |
Cardiac tamponade | 30.44 | 10.65 | 43 | 113461 | 4557 | 53231005 |
Intestinal haemorrhage | 30.28 | 10.65 | 37 | 113467 | 3403 | 53232159 |
Irritability | 30.19 | 10.65 | 14 | 113490 | 30939 | 53204623 |
Chest wall haematoma | 30.18 | 10.65 | 12 | 113492 | 161 | 53235401 |
Creatinine renal clearance abnormal | 30.04 | 10.65 | 15 | 113489 | 354 | 53235208 |
Potentiating drug interaction | 30.00 | 10.65 | 41 | 113463 | 4212 | 53231350 |
Ear haemorrhage | 29.92 | 10.65 | 24 | 113480 | 1320 | 53234242 |
Arterial haemorrhage | 29.88 | 10.65 | 27 | 113477 | 1749 | 53233813 |
Spinal cord haemorrhage | 29.86 | 10.65 | 13 | 113491 | 222 | 53235340 |
Stress | 29.86 | 10.65 | 47 | 113457 | 57037 | 53178525 |
Oesophageal haemorrhage | 29.46 | 10.65 | 17 | 113487 | 540 | 53235022 |
Syncope | 29.01 | 10.65 | 365 | 113139 | 111628 | 53123934 |
Hypersensitivity vasculitis | 28.62 | 10.65 | 41 | 113463 | 4402 | 53231160 |
Cerebral artery thrombosis | 28.07 | 10.65 | 15 | 113489 | 409 | 53235153 |
Renal infarct | 27.98 | 10.65 | 24 | 113480 | 1450 | 53234112 |
Brain herniation | 27.78 | 10.65 | 35 | 113469 | 3321 | 53232241 |
Peripheral artery thrombosis | 27.72 | 10.65 | 27 | 113477 | 1923 | 53233639 |
Fluid overload | 27.63 | 10.65 | 125 | 113379 | 27706 | 53207856 |
Injury | 27.59 | 10.65 | 41 | 113463 | 50930 | 53184632 |
Deep vein thrombosis postoperative | 27.54 | 10.65 | 21 | 113483 | 1072 | 53234490 |
Drug dependence | 27.51 | 10.65 | 6 | 113498 | 21466 | 53214096 |
Toxic epidermal necrolysis | 27.44 | 10.65 | 8 | 113496 | 23542 | 53212020 |
Dry eye | 27.39 | 10.65 | 19 | 113485 | 33625 | 53201937 |
Basal cell carcinoma | 27.29 | 10.65 | 8 | 113496 | 23461 | 53212101 |
Aggression | 27.17 | 10.65 | 8 | 113496 | 23395 | 53212167 |
Type 2 diabetes mellitus | 26.98 | 10.65 | 17 | 113487 | 31653 | 53203909 |
Gastrointestinal polyp haemorrhage | 26.80 | 10.65 | 11 | 113493 | 161 | 53235401 |
International normalised ratio abnormal | 26.76 | 10.65 | 33 | 113471 | 3064 | 53232498 |
Mood swings | 26.66 | 10.65 | 3 | 113501 | 17483 | 53218079 |
Purpura | 26.41 | 10.65 | 66 | 113438 | 10787 | 53224775 |
Aspartate aminotransferase increased | 26.36 | 10.65 | 91 | 113413 | 83938 | 53151624 |
Haematoma infection | 26.36 | 10.65 | 16 | 113488 | 559 | 53235003 |
Petechiae | 26.32 | 10.65 | 76 | 113428 | 13529 | 53222033 |
Sputum increased | 26.29 | 10.65 | 28 | 113476 | 2218 | 53233344 |
Lower respiratory tract infection | 26.26 | 10.65 | 102 | 113402 | 90879 | 53144683 |
Nasal polyps | 26.18 | 10.65 | 32 | 113472 | 2944 | 53232618 |
Joint stiffness | 26.15 | 10.65 | 16 | 113488 | 30267 | 53205295 |
Right ventricular failure | 26.01 | 10.65 | 87 | 113417 | 16756 | 53218806 |
C-reactive protein increased | 26.00 | 10.65 | 67 | 113437 | 67819 | 53167743 |
Cytomegalovirus infection | 25.99 | 10.65 | 5 | 113499 | 19534 | 53216028 |
Haemoperitoneum | 25.91 | 10.65 | 30 | 113474 | 2607 | 53232955 |
Respiratory symptom | 25.80 | 10.65 | 30 | 113474 | 2619 | 53232943 |
Cerebral thrombosis | 25.79 | 10.65 | 25 | 113479 | 1770 | 53233792 |
Arterial injury | 25.63 | 10.65 | 11 | 113493 | 181 | 53235381 |
Cardiac pacemaker insertion | 25.59 | 10.65 | 36 | 113468 | 3801 | 53231761 |
Menometrorrhagia | 25.51 | 10.65 | 19 | 113485 | 936 | 53234626 |
Intentional self-injury | 25.34 | 10.65 | 11 | 113493 | 25273 | 53210289 |
Therapeutic response increased | 25.24 | 10.65 | 13 | 113491 | 328 | 53235234 |
Arrhythmia | 25.23 | 10.65 | 149 | 113355 | 36630 | 53198932 |
Atrial flutter | 25.13 | 10.65 | 60 | 113444 | 9531 | 53226031 |
Injection site rash | 24.88 | 10.65 | 3 | 113501 | 16576 | 53218986 |
Premature baby | 24.44 | 10.65 | 6 | 113498 | 19795 | 53215767 |
Malignant neoplasm progression | 24.15 | 10.65 | 75 | 113429 | 71466 | 53164096 |
Cardiac ablation | 24.01 | 10.65 | 21 | 113483 | 1303 | 53234259 |
Diverticulum | 23.96 | 10.65 | 67 | 113437 | 11712 | 53223850 |
Multiple sclerosis | 23.94 | 10.65 | 14 | 113490 | 27139 | 53208423 |
Overdose | 23.86 | 10.65 | 133 | 113371 | 107603 | 53127959 |
Premature delivery | 23.67 | 10.65 | 13 | 113491 | 26091 | 53209471 |
Haemorrhagic erosive gastritis | 23.47 | 10.65 | 12 | 113492 | 298 | 53235264 |
Crying | 23.43 | 10.65 | 9 | 113495 | 22253 | 53213309 |
Thrombophlebitis superficial | 23.42 | 10.65 | 40 | 113464 | 4995 | 53230567 |
Bone marrow failure | 23.23 | 10.65 | 18 | 113486 | 30097 | 53205465 |
Blood pressure increased | 22.86 | 10.65 | 190 | 113314 | 140289 | 53095273 |
Sleep disorder | 22.62 | 10.65 | 58 | 113446 | 58812 | 53176750 |
Drug withdrawal syndrome | 22.58 | 10.65 | 16 | 113488 | 28006 | 53207556 |
Brain stem infarction | 22.57 | 10.65 | 17 | 113487 | 852 | 53234710 |
Ear pain | 22.55 | 10.65 | 18 | 113486 | 29655 | 53205907 |
Diverticulitis intestinal haemorrhagic | 22.49 | 10.65 | 9 | 113495 | 123 | 53235439 |
Sinus tachycardia | 22.47 | 10.65 | 11 | 113493 | 23561 | 53212001 |
Mucosal haemorrhage | 22.45 | 10.65 | 17 | 113487 | 859 | 53234703 |
Catheter management | 22.44 | 10.65 | 29 | 113475 | 2823 | 53232739 |
Fibromyalgia | 22.38 | 10.65 | 37 | 113467 | 44038 | 53191524 |
Tremor | 21.87 | 10.65 | 167 | 113337 | 125569 | 53109993 |
Osteopenia | 21.82 | 10.65 | 6 | 113498 | 18349 | 53217213 |
Spontaneous haemorrhage | 21.67 | 10.65 | 11 | 113493 | 269 | 53235293 |
Injection site bruising | 21.65 | 10.65 | 29 | 113475 | 37617 | 53197945 |
Oropharyngeal pain | 21.64 | 10.65 | 94 | 113410 | 81174 | 53154388 |
Arthritis | 21.45 | 10.65 | 104 | 113400 | 87194 | 53148368 |
Erythema | 21.36 | 10.65 | 222 | 113282 | 156747 | 53078815 |
Bradyarrhythmia | 21.36 | 10.65 | 24 | 113480 | 2019 | 53233543 |
Intracranial haematoma | 21.21 | 10.65 | 12 | 113492 | 367 | 53235195 |
Hypoaesthesia | 21.13 | 10.65 | 181 | 113323 | 132814 | 53102748 |
Drug resistance | 21.12 | 10.65 | 8 | 113496 | 19954 | 53215608 |
Muscle spasticity | 20.89 | 10.65 | 6 | 113498 | 17832 | 53217730 |
Underdose | 20.87 | 10.65 | 96 | 113408 | 21426 | 53214136 |
Urticaria | 20.68 | 10.65 | 187 | 113317 | 135698 | 53099864 |
Pelvic haemorrhage | 20.65 | 10.65 | 9 | 113495 | 154 | 53235408 |
Product use issue | 20.42 | 10.65 | 194 | 113310 | 139390 | 53096172 |
Foot deformity | 20.40 | 10.65 | 7 | 113497 | 18561 | 53217001 |
Ventricle rupture | 20.30 | 10.65 | 5 | 113499 | 10 | 53235552 |
Abortion spontaneous | 20.28 | 10.65 | 43 | 113461 | 46592 | 53188970 |
Migraine | 20.23 | 10.65 | 95 | 113409 | 80322 | 53155240 |
Injection site warmth | 20.15 | 10.65 | 3 | 113501 | 14125 | 53221437 |
Serotonin syndrome | 20.09 | 10.65 | 16 | 113488 | 26390 | 53209172 |
Oral herpes | 20.01 | 10.65 | 10 | 113494 | 21169 | 53214393 |
Hypercoagulation | 19.99 | 10.65 | 24 | 113480 | 2167 | 53233395 |
Arterial thrombosis | 19.94 | 10.65 | 20 | 113484 | 1476 | 53234086 |
Presyncope | 19.86 | 10.65 | 109 | 113395 | 26085 | 53209477 |
Neuralgia | 19.53 | 10.65 | 13 | 113491 | 23508 | 53212054 |
Pruritus | 19.50 | 10.65 | 476 | 113028 | 293356 | 52942206 |
Thrombocytosis | 19.50 | 10.65 | 39 | 113465 | 5493 | 53230069 |
Gait disturbance | 19.49 | 10.65 | 230 | 113274 | 158612 | 53076950 |
Product administration error | 19.39 | 10.65 | 94 | 113410 | 21437 | 53214125 |
Osteomyelitis | 19.32 | 10.65 | 14 | 113490 | 24221 | 53211341 |
Haemoglobin abnormal | 19.31 | 10.65 | 35 | 113469 | 4579 | 53230983 |
Periorbital haematoma | 19.26 | 10.65 | 15 | 113489 | 790 | 53234772 |
Urogenital haemorrhage | 19.25 | 10.65 | 10 | 113494 | 257 | 53235305 |
Asthenia | 19.15 | 10.65 | 904 | 112600 | 342686 | 52892876 |
Neutrophil count decreased | 19.15 | 10.65 | 48 | 113456 | 49050 | 53186512 |
Heart rate irregular | 19.09 | 10.65 | 90 | 113414 | 20294 | 53215268 |
Multiple organ dysfunction syndrome | 19.06 | 10.65 | 58 | 113446 | 55619 | 53179943 |
Red blood cell sedimentation rate increased | 18.95 | 10.65 | 19 | 113485 | 28038 | 53207524 |
Leukopenia | 18.94 | 10.65 | 86 | 113418 | 73377 | 53162185 |
Rhinorrhoea | 18.92 | 10.65 | 55 | 113449 | 53523 | 53182039 |
Nausea | 18.90 | 10.65 | 1370 | 112134 | 754721 | 52480841 |
Platelet aggregation inhibition | 18.85 | 10.65 | 8 | 113496 | 128 | 53235434 |
Generalised tonic-clonic seizure | 18.83 | 10.65 | 20 | 113484 | 28738 | 53206824 |
Pulmonary endarterectomy | 18.68 | 10.65 | 8 | 113496 | 131 | 53235431 |
Hepatic steatosis | 18.65 | 10.65 | 17 | 113487 | 26242 | 53209320 |
Bradycardia | 18.57 | 10.65 | 232 | 113272 | 70824 | 53164738 |
Female genital tract fistula | 18.56 | 10.65 | 32 | 113472 | 4026 | 53231536 |
Post procedural pulmonary embolism | 18.54 | 10.65 | 10 | 113494 | 278 | 53235284 |
Gastric pH increased | 18.42 | 10.65 | 6 | 113498 | 43 | 53235519 |
Metabolic acidosis | 18.33 | 10.65 | 39 | 113465 | 42203 | 53193359 |
Confusional state | 18.20 | 10.65 | 297 | 113207 | 193924 | 53041638 |
Prosthetic cardiac valve thrombosis | 18.18 | 10.65 | 5 | 113499 | 18 | 53235544 |
Body temperature increased | 18.12 | 10.65 | 26 | 113478 | 32773 | 53202789 |
Ear infection | 18.12 | 10.65 | 17 | 113487 | 25883 | 53209679 |
C-reactive protein abnormal | 18.07 | 10.65 | 17 | 113487 | 25853 | 53209709 |
Dystonia | 18.04 | 10.65 | 3 | 113501 | 13018 | 53222544 |
Fibrin D dimer increased | 18.01 | 10.65 | 34 | 113470 | 4589 | 53230973 |
Orthopnoea | 17.99 | 10.65 | 40 | 113464 | 6064 | 53229498 |
Breast haematoma | 17.96 | 10.65 | 9 | 113495 | 214 | 53235348 |
Paraplegia | 17.90 | 10.65 | 25 | 113479 | 2622 | 53232940 |
Swelling face | 17.87 | 10.65 | 62 | 113442 | 57106 | 53178456 |
Anal haemorrhage | 17.86 | 10.65 | 20 | 113484 | 1676 | 53233886 |
Quadriplegia | 17.84 | 10.65 | 21 | 113483 | 1857 | 53233705 |
Normochromic normocytic anaemia | 17.79 | 10.65 | 34 | 113470 | 4632 | 53230930 |
Hysterectomy | 17.71 | 10.65 | 49 | 113455 | 8512 | 53227050 |
Polyp | 17.71 | 10.65 | 39 | 113465 | 5875 | 53229687 |
Emergency care | 17.68 | 10.65 | 15 | 113489 | 893 | 53234669 |
Subcapsular renal haematoma | 17.67 | 10.65 | 10 | 113494 | 306 | 53235256 |
Toothache | 17.63 | 10.65 | 8 | 113496 | 17906 | 53217656 |
Haemorrhagic infarction | 17.61 | 10.65 | 10 | 113494 | 308 | 53235254 |
Arrhythmogenic right ventricular dysplasia | 17.58 | 10.65 | 5 | 113499 | 21 | 53235541 |
Antineutrophil cytoplasmic antibody positive | 17.36 | 10.65 | 12 | 113492 | 525 | 53235037 |
Product dose omission issue | 17.34 | 10.65 | 532 | 112972 | 191088 | 53044474 |
Mucosal inflammation | 17.34 | 10.65 | 41 | 113463 | 42743 | 53192819 |
Vascular stent thrombosis | 17.28 | 10.65 | 15 | 113489 | 921 | 53234641 |
Thrombotic stroke | 17.18 | 10.65 | 12 | 113492 | 534 | 53235028 |
Respiratory arrest | 17.17 | 10.65 | 28 | 113476 | 33512 | 53202050 |
Urethral haemorrhage | 17.13 | 10.65 | 6 | 113498 | 55 | 53235507 |
Haemorrhagic hepatic cyst | 17.04 | 10.65 | 5 | 113499 | 24 | 53235538 |
Oesophagitis haemorrhagic | 16.97 | 10.65 | 11 | 113493 | 432 | 53235130 |
Ulcer haemorrhage | 16.90 | 10.65 | 29 | 113475 | 3635 | 53231927 |
Death | 16.85 | 10.65 | 925 | 112579 | 356307 | 52879255 |
Mesenteric haemorrhage | 16.85 | 10.65 | 6 | 113498 | 58 | 53235504 |
Post procedural stroke | 16.76 | 10.65 | 6 | 113498 | 59 | 53235503 |
Catheter site discharge | 16.66 | 10.65 | 21 | 113483 | 1993 | 53233569 |
Arteriovenous malformation | 16.52 | 10.65 | 17 | 113487 | 1294 | 53234268 |
Photophobia | 16.41 | 10.65 | 7 | 113497 | 16251 | 53219311 |
Coagulation time prolonged | 16.38 | 10.65 | 17 | 113487 | 1307 | 53234255 |
Intentional product use issue | 16.32 | 10.65 | 89 | 113415 | 72405 | 53163157 |
Tenderness | 16.25 | 10.65 | 11 | 113493 | 19719 | 53215843 |
Throat tightness | 16.24 | 10.65 | 14 | 113490 | 22202 | 53213360 |
Neuroleptic malignant syndrome | 16.17 | 10.65 | 3 | 113501 | 12030 | 53223532 |
Depressed mood | 16.14 | 10.65 | 34 | 113470 | 36930 | 53198632 |
Hypochromic anaemia | 16.11 | 10.65 | 20 | 113484 | 1869 | 53233693 |
White blood cell count increased | 15.95 | 10.65 | 48 | 113456 | 46197 | 53189365 |
Pain in jaw | 15.89 | 10.65 | 144 | 113360 | 40525 | 53195037 |
Hypoglycaemia | 15.87 | 10.65 | 68 | 113436 | 58945 | 53176617 |
Venous haemorrhage | 15.86 | 10.65 | 8 | 113496 | 193 | 53235369 |
Influenza like illness | 15.84 | 10.65 | 71 | 113433 | 60788 | 53174774 |
Intervertebral disc protrusion | 15.83 | 10.65 | 14 | 113490 | 21931 | 53213631 |
Therapeutic procedure | 15.81 | 10.65 | 14 | 113490 | 883 | 53234679 |
Blood glucose increased | 15.80 | 10.65 | 98 | 113406 | 77263 | 53158299 |
Mania | 15.79 | 10.65 | 3 | 113501 | 11826 | 53223736 |
Peritoneal haematoma | 15.77 | 10.65 | 6 | 113498 | 71 | 53235491 |
Coagulation test abnormal | 15.75 | 10.65 | 13 | 113491 | 745 | 53234817 |
Spinal subdural haematoma | 15.74 | 10.65 | 7 | 113497 | 126 | 53235436 |
Carotid artery occlusion | 15.73 | 10.65 | 24 | 113480 | 2725 | 53232837 |
Abnormal behaviour | 15.71 | 10.65 | 14 | 113490 | 21852 | 53213710 |
Cerebral ventricle collapse | 15.70 | 10.65 | 5 | 113499 | 33 | 53235529 |
Inappropriate schedule of product administration | 15.69 | 10.65 | 235 | 113269 | 74643 | 53160919 |
Putamen haemorrhage | 15.67 | 10.65 | 8 | 113496 | 198 | 53235364 |
Mallory-Weiss syndrome | 15.65 | 10.65 | 18 | 113486 | 1553 | 53234009 |
Antiphospholipid syndrome | 15.55 | 10.65 | 19 | 113485 | 1747 | 53233815 |
Influenza | 15.51 | 10.65 | 129 | 113375 | 95250 | 53140312 |
Right hemisphere deficit syndrome | 15.47 | 10.65 | 3 | 113501 | 0 | 53235562 |
Orthostatic heart rate response increased | 15.47 | 10.65 | 3 | 113501 | 0 | 53235562 |
CHA2DS2-VASc annual stroke risk high | 15.47 | 10.65 | 3 | 113501 | 0 | 53235562 |
Spinal cord injury thoracic | 15.47 | 10.65 | 3 | 113501 | 0 | 53235562 |
Contraindication to surgery | 15.47 | 10.65 | 3 | 113501 | 0 | 53235562 |
Procedural pain | 15.40 | 10.65 | 6 | 113498 | 14711 | 53220851 |
Post procedural discharge | 15.38 | 10.65 | 10 | 113494 | 395 | 53235167 |
Aortic valve calcification | 15.33 | 10.65 | 10 | 113494 | 397 | 53235165 |
Post procedural haematuria | 15.21 | 10.65 | 5 | 113499 | 37 | 53235525 |
Intentional product misuse | 15.14 | 10.65 | 54 | 113450 | 49338 | 53186224 |
Stevens-Johnson syndrome | 15.11 | 10.65 | 18 | 113486 | 24564 | 53210998 |
Cerebral vascular occlusion | 15.10 | 10.65 | 4 | 113500 | 12 | 53235550 |
Cognitive disorder | 15.07 | 10.65 | 47 | 113457 | 44731 | 53190831 |
Meningorrhagia | 14.94 | 10.65 | 7 | 113497 | 143 | 53235419 |
Cerebellar haematoma | 14.92 | 10.65 | 10 | 113494 | 416 | 53235146 |
Medical device site haemorrhage | 14.87 | 10.65 | 5 | 113499 | 40 | 53235522 |
Rhabdomyolysis | 14.86 | 10.65 | 46 | 113458 | 43877 | 53191685 |
Retinal vein thrombosis | 14.81 | 10.65 | 10 | 113494 | 421 | 53235141 |
Rectal polyp | 14.77 | 10.65 | 14 | 113490 | 964 | 53234598 |
Lymphocyte count decreased | 14.76 | 10.65 | 23 | 113481 | 28029 | 53207533 |
White blood cell count decreased | 14.60 | 10.65 | 182 | 113322 | 124293 | 53111269 |
Anaphylactic shock | 14.59 | 10.65 | 15 | 113489 | 21878 | 53213684 |
Chronic gastrointestinal bleeding | 14.46 | 10.65 | 7 | 113497 | 154 | 53235408 |
Chronic gastritis | 14.41 | 10.65 | 22 | 113482 | 2500 | 53233062 |
Osteonecrosis of jaw | 14.36 | 10.65 | 35 | 113469 | 36111 | 53199451 |
Withdrawal syndrome | 14.31 | 10.65 | 12 | 113492 | 19289 | 53216273 |
Autoimmune nephritis | 14.25 | 10.65 | 9 | 113495 | 338 | 53235224 |
Vulval haemorrhage | 14.22 | 10.65 | 4 | 113500 | 16 | 53235546 |
Vascular device infection | 14.20 | 10.65 | 30 | 113474 | 4391 | 53231171 |
Retinal ischaemia | 14.20 | 10.65 | 9 | 113495 | 340 | 53235222 |
Bleeding varicose vein | 14.13 | 10.65 | 8 | 113496 | 245 | 53235317 |
Respiratory tract haemorrhage | 14.10 | 10.65 | 10 | 113494 | 456 | 53235106 |
Lipase increased | 14.09 | 10.65 | 48 | 113456 | 9330 | 53226232 |
No adverse event | 14.09 | 10.65 | 40 | 113464 | 39225 | 53196337 |
Myoclonus | 14.08 | 10.65 | 8 | 113496 | 15756 | 53219806 |
Muscle rigidity | 13.95 | 10.65 | 3 | 113501 | 10838 | 53224724 |
Traumatic fracture | 13.90 | 10.65 | 11 | 113493 | 593 | 53234969 |
Protein S deficiency | 13.89 | 10.65 | 5 | 113499 | 50 | 53235512 |
Rheumatoid nodule | 13.88 | 10.65 | 4 | 113500 | 11860 | 53223702 |
Exsanguination | 13.84 | 10.65 | 4 | 113500 | 18 | 53235544 |
Psychotic disorder | 13.80 | 10.65 | 19 | 113485 | 24366 | 53211196 |
Monoparesis | 13.80 | 10.65 | 17 | 113487 | 1577 | 53233985 |
Cholelithiasis | 13.78 | 10.65 | 43 | 113461 | 40921 | 53194641 |
Splenic haematoma | 13.75 | 10.65 | 6 | 113498 | 103 | 53235459 |
Duodenal polyp | 13.70 | 10.65 | 6 | 113498 | 104 | 53235458 |
Jaundice acholuric | 13.60 | 10.65 | 6 | 113498 | 106 | 53235456 |
Brain compression | 13.58 | 10.65 | 9 | 113495 | 367 | 53235195 |
Coronary artery disease | 13.58 | 10.65 | 32 | 113472 | 33405 | 53202157 |
Respiratory disorder | 13.56 | 10.65 | 33 | 113471 | 34064 | 53201498 |
Catheter site pruritus | 13.51 | 10.65 | 19 | 113485 | 2005 | 53233557 |
Anticoagulant therapy | 13.50 | 10.65 | 4 | 113500 | 20 | 53235542 |
Pancytopenia | 13.45 | 10.65 | 126 | 113378 | 90802 | 53144760 |
Incorrect dosage administered | 13.43 | 10.65 | 18 | 113486 | 1815 | 53233747 |
Injection site urticaria | 13.43 | 10.65 | 5 | 113499 | 12602 | 53222960 |
Pulmonary artery thrombosis | 13.41 | 10.65 | 12 | 113492 | 767 | 53234795 |
Device expulsion | 13.38 | 10.65 | 27 | 113477 | 29786 | 53205776 |
Degenerative mitral valve disease | 13.33 | 10.65 | 4 | 113500 | 21 | 53235541 |
Ovarian cyst | 13.28 | 10.65 | 8 | 113496 | 15261 | 53220301 |
Tooth abscess | 13.26 | 10.65 | 6 | 113498 | 13452 | 53222110 |
Pulmonary haematoma | 13.23 | 10.65 | 5 | 113499 | 58 | 53235504 |
Anastomotic ulcer haemorrhage | 13.23 | 10.65 | 5 | 113499 | 58 | 53235504 |
Throat irritation | 13.13 | 10.65 | 30 | 113474 | 31651 | 53203911 |
Dyspnoea at rest | 13.12 | 10.65 | 27 | 113477 | 3880 | 53231682 |
Contraindicated product prescribed | 13.09 | 10.65 | 12 | 113492 | 792 | 53234770 |
Thrombotic cerebral infarction | 13.06 | 10.65 | 6 | 113498 | 117 | 53235445 |
Anger | 13.05 | 10.65 | 5 | 113499 | 12385 | 53223177 |
Viral infection | 13.04 | 10.65 | 31 | 113473 | 32264 | 53203298 |
Incorrect route of product administration | 13.03 | 10.65 | 13 | 113491 | 19231 | 53216331 |
Catheter site erythema | 13.00 | 10.65 | 28 | 113476 | 4154 | 53231408 |
Vena cava thrombosis | 13.00 | 10.65 | 20 | 113484 | 2288 | 53233274 |
Therapy non-responder | 12.96 | 10.65 | 57 | 113447 | 49063 | 53186499 |
Mydriasis | 12.92 | 10.65 | 4 | 113500 | 11322 | 53224240 |
Weight decreased | 12.88 | 10.65 | 391 | 113113 | 234557 | 53001005 |
Accidental exposure to product | 12.85 | 10.65 | 19 | 113485 | 23655 | 53211907 |
Panic attack | 12.83 | 10.65 | 16 | 113488 | 21402 | 53214160 |
Back pain | 12.80 | 10.65 | 390 | 113114 | 233857 | 53001705 |
Epidural haemorrhage | 12.78 | 10.65 | 6 | 113498 | 123 | 53235439 |
Pharyngitis | 12.65 | 10.65 | 13 | 113491 | 18967 | 53216595 |
Diastolic dysfunction | 12.64 | 10.65 | 34 | 113470 | 5810 | 53229752 |
Lacunar stroke | 12.61 | 10.65 | 6 | 113498 | 127 | 53235435 |
Incision site haematoma | 12.58 | 10.65 | 5 | 113499 | 67 | 53235495 |
Thrombectomy | 12.55 | 10.65 | 7 | 113497 | 208 | 53235354 |
Anaemia macrocytic | 12.55 | 10.65 | 22 | 113482 | 2804 | 53232758 |
Constipation | 12.45 | 10.65 | 324 | 113180 | 198088 | 53037474 |
Muscle twitching | 12.44 | 10.65 | 10 | 113494 | 16416 | 53219146 |
Craniocerebral injury | 12.43 | 10.65 | 20 | 113484 | 2378 | 53233184 |
Acute respiratory distress syndrome | 12.40 | 10.65 | 19 | 113485 | 23313 | 53212249 |
Extra dose administered | 12.39 | 10.65 | 32 | 113472 | 5338 | 53230224 |
Blood blister | 12.38 | 10.65 | 17 | 113487 | 1754 | 53233808 |
Blood creatine phosphokinase increased | 12.37 | 10.65 | 27 | 113477 | 28958 | 53206604 |
Pelvic haematoma | 12.37 | 10.65 | 10 | 113494 | 556 | 53235006 |
Headache | 12.37 | 10.65 | 979 | 112525 | 535842 | 52699720 |
Cardiac failure acute | 12.34 | 10.65 | 45 | 113459 | 9047 | 53226515 |
Thrombophlebitis | 12.28 | 10.65 | 29 | 113475 | 4574 | 53230988 |
Bursitis | 12.26 | 10.65 | 18 | 113486 | 22474 | 53213088 |
Lymphadenopathy | 12.24 | 10.65 | 38 | 113466 | 36217 | 53199345 |
Basilar artery thrombosis | 12.20 | 10.65 | 6 | 113498 | 137 | 53235425 |
Retinal artery embolism | 12.19 | 10.65 | 5 | 113499 | 73 | 53235489 |
Osteorrhagia | 12.18 | 10.65 | 3 | 113501 | 6 | 53235556 |
Manufacturing materials issue | 12.18 | 10.65 | 3 | 113501 | 6 | 53235556 |
Lymphostasis | 12.18 | 10.65 | 3 | 113501 | 6 | 53235556 |
Peritonitis | 12.17 | 10.65 | 17 | 113487 | 21670 | 53213892 |
Respiratory depression | 12.17 | 10.65 | 6 | 113498 | 12800 | 53222762 |
Peripheral artery occlusion | 12.14 | 10.65 | 14 | 113490 | 1211 | 53234351 |
Infective pericardial effusion | 12.12 | 10.65 | 4 | 113500 | 30 | 53235532 |
Cholestatic liver injury | 12.10 | 10.65 | 20 | 113484 | 2431 | 53233131 |
Vision blurred | 12.08 | 10.65 | 120 | 113384 | 85484 | 53150078 |
Postoperative thrombosis | 12.08 | 10.65 | 6 | 113498 | 140 | 53235422 |
Blindness unilateral | 12.07 | 10.65 | 33 | 113471 | 5694 | 53229868 |
Spinal cord compression | 12.02 | 10.65 | 26 | 113478 | 3868 | 53231694 |
Post thrombotic syndrome | 11.99 | 10.65 | 10 | 113494 | 581 | 53234981 |
Brain contusion | 11.99 | 10.65 | 10 | 113494 | 581 | 53234981 |
Colon cancer | 11.99 | 10.65 | 47 | 113457 | 9778 | 53225784 |
Vascular purpura | 11.88 | 10.65 | 15 | 113489 | 1426 | 53234136 |
Hypercholesterolaemia | 11.87 | 10.65 | 6 | 113498 | 12620 | 53222942 |
Medication error | 11.87 | 10.65 | 124 | 113380 | 36241 | 53199321 |
Laryngeal haemorrhage | 11.87 | 10.65 | 3 | 113501 | 7 | 53235555 |
Investigation | 11.85 | 10.65 | 16 | 113488 | 1625 | 53233937 |
Lymphopenia | 11.85 | 10.65 | 11 | 113493 | 16832 | 53218730 |
Hypercalcaemia | 11.85 | 10.65 | 21 | 113483 | 24327 | 53211235 |
Catheter site haemorrhage | 11.84 | 10.65 | 22 | 113482 | 2933 | 53232629 |
Catheter site bruise | 11.84 | 10.65 | 8 | 113496 | 337 | 53235225 |
Chondrocalcinosis | 11.83 | 10.65 | 10 | 113494 | 592 | 53234970 |
Central nervous system haemorrhage | 11.81 | 10.65 | 6 | 113498 | 147 | 53235415 |
Anticoagulation drug level decreased | 11.79 | 10.65 | 4 | 113500 | 33 | 53235529 |
Soft tissue haemorrhage | 11.78 | 10.65 | 7 | 113497 | 235 | 53235327 |
Spinal osteoarthritis | 11.76 | 10.65 | 9 | 113495 | 15148 | 53220414 |
Haemorrhagic diathesis | 11.71 | 10.65 | 28 | 113476 | 4450 | 53231112 |
Intracranial aneurysm | 11.64 | 10.65 | 24 | 113480 | 3455 | 53232107 |
Osteoarthritis | 11.61 | 10.65 | 95 | 113409 | 70391 | 53165171 |
Infarction | 11.54 | 10.65 | 20 | 113484 | 2527 | 53233035 |
Extrapyramidal disorder | 11.50 | 10.65 | 6 | 113498 | 12396 | 53223166 |
Cerebellar ischaemia | 11.49 | 10.65 | 4 | 113500 | 36 | 53235526 |
Hypotension | 11.40 | 10.65 | 655 | 112849 | 253421 | 52982141 |
Pseudomonas infection | 11.34 | 10.65 | 4 | 113500 | 10424 | 53225138 |
Tumour haemorrhage | 11.30 | 10.65 | 15 | 113489 | 1499 | 53234063 |
Chronic sinusitis | 11.30 | 10.65 | 33 | 113471 | 5912 | 53229650 |
Tonic clonic movements | 11.28 | 10.65 | 14 | 113490 | 1308 | 53234254 |
Affect lability | 11.26 | 10.65 | 3 | 113501 | 9372 | 53226190 |
Hyperlipidaemia | 11.25 | 10.65 | 15 | 113489 | 19500 | 53216062 |
Brain natriuretic peptide abnormal | 11.24 | 10.65 | 8 | 113496 | 367 | 53235195 |
Tracheal haemorrhage | 11.18 | 10.65 | 6 | 113498 | 165 | 53235397 |
Osteonecrosis | 11.14 | 10.65 | 25 | 113479 | 26550 | 53209012 |
Ataxia | 11.12 | 10.65 | 9 | 113495 | 14728 | 53220834 |
Cerebral amyloid angiopathy | 11.12 | 10.65 | 6 | 113498 | 167 | 53235395 |
Anti factor X activity increased | 11.09 | 10.65 | 3 | 113501 | 10 | 53235552 |
Infective pulmonary exacerbation of cystic fibrosis | 10.95 | 10.65 | 5 | 113499 | 11151 | 53224411 |
Contraindication to medical treatment | 10.95 | 10.65 | 10 | 113494 | 657 | 53234905 |
Carpal tunnel syndrome | 10.93 | 10.65 | 13 | 113491 | 17754 | 53217808 |
Breast cancer | 10.89 | 10.65 | 61 | 113443 | 49297 | 53186265 |
Degenerative aortic valve disease | 10.86 | 10.65 | 5 | 113499 | 98 | 53235464 |
Peptostreptococcus infection | 10.86 | 10.65 | 4 | 113500 | 43 | 53235519 |
Neurotoxicity | 10.82 | 10.65 | 10 | 113494 | 15339 | 53220223 |
Brain stem stroke | 10.82 | 10.65 | 7 | 113497 | 274 | 53235288 |
Tuberculosis | 10.81 | 10.65 | 5 | 113499 | 11066 | 53224496 |
Myelosuppression | 10.77 | 10.65 | 7 | 113497 | 12821 | 53222741 |
Right atrial enlargement | 10.77 | 10.65 | 5 | 113499 | 100 | 53235462 |
Muscle spasms | 10.76 | 10.65 | 212 | 113292 | 134583 | 53100979 |
Vascular stent insertion | 10.66 | 10.65 | 3 | 113501 | 12 | 53235550 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Gastrointestinal haemorrhage | 4710.70 | 11.94 | 3136 | 103432 | 83746 | 32323212 |
Deep vein thrombosis | 1833.06 | 11.94 | 1579 | 104989 | 62134 | 32344824 |
Haemorrhage | 1485.61 | 11.94 | 1257 | 105311 | 48191 | 32358767 |
Haematuria | 1382.57 | 11.94 | 1195 | 105373 | 47166 | 32359792 |
Pulmonary embolism | 1294.54 | 11.94 | 1479 | 105089 | 82180 | 32324778 |
Epistaxis | 1143.38 | 11.94 | 1146 | 105422 | 54709 | 32352249 |
Cerebral haemorrhage | 1085.56 | 11.94 | 904 | 105664 | 33843 | 32373115 |
Haemorrhage intracranial | 974.35 | 11.94 | 622 | 105946 | 15265 | 32391693 |
Ischaemic stroke | 931.35 | 11.94 | 628 | 105940 | 16948 | 32390010 |
Upper gastrointestinal haemorrhage | 825.65 | 11.94 | 659 | 105909 | 23190 | 32383768 |
Cerebrovascular accident | 816.40 | 11.94 | 1197 | 105371 | 85123 | 32321835 |
Cerebral infarction | 743.32 | 11.94 | 660 | 105908 | 26954 | 32380004 |
Rectal haemorrhage | 638.16 | 11.94 | 697 | 105871 | 36726 | 32370232 |
Thrombosis | 596.03 | 11.94 | 742 | 105826 | 45012 | 32361946 |
Atrial thrombosis | 592.98 | 11.94 | 229 | 106339 | 1758 | 32405200 |
Haematoma | 580.73 | 11.94 | 557 | 106011 | 25127 | 32381831 |
Subdural haematoma | 507.38 | 11.94 | 462 | 106106 | 19491 | 32387467 |
Lower gastrointestinal haemorrhage | 505.41 | 11.94 | 331 | 106237 | 8486 | 32398472 |
Embolic stroke | 466.57 | 11.94 | 234 | 106334 | 3540 | 32403418 |
Melaena | 465.50 | 11.94 | 571 | 105997 | 34094 | 32372864 |
Haemorrhagic stroke | 463.74 | 11.94 | 280 | 106288 | 6198 | 32400760 |
Internal haemorrhage | 390.74 | 11.94 | 225 | 106343 | 4547 | 32402411 |
Gastric haemorrhage | 380.75 | 11.94 | 291 | 106277 | 9585 | 32397373 |
Post procedural haemorrhage | 372.56 | 11.94 | 268 | 106300 | 8032 | 32398926 |
Transient ischaemic attack | 327.14 | 11.94 | 413 | 106155 | 25381 | 32381577 |
Haemoptysis | 314.85 | 11.94 | 464 | 106104 | 33061 | 32373897 |
Blood loss anaemia | 279.55 | 11.94 | 222 | 106346 | 7740 | 32399218 |
Anaemia | 278.77 | 11.94 | 1456 | 105112 | 222168 | 32184790 |
Blood urine present | 251.35 | 11.94 | 235 | 106333 | 10250 | 32396708 |
Diverticulum intestinal haemorrhagic | 250.68 | 11.94 | 129 | 106439 | 2065 | 32404893 |
Haemoglobin decreased | 239.26 | 11.94 | 898 | 105670 | 118773 | 32288185 |
Pericardial haemorrhage | 232.82 | 11.94 | 138 | 106430 | 2948 | 32404010 |
Haemarthrosis | 230.99 | 11.94 | 142 | 106426 | 3248 | 32403710 |
Gingival bleeding | 228.86 | 11.94 | 187 | 106381 | 6794 | 32400164 |
Basal ganglia haemorrhage | 226.62 | 11.94 | 91 | 106477 | 783 | 32406175 |
Haemorrhagic arteriovenous malformation | 225.64 | 11.94 | 73 | 106495 | 306 | 32406652 |
Toxicity to various agents | 219.98 | 11.94 | 158 | 106410 | 177883 | 32229075 |
Haematochezia | 217.07 | 11.94 | 429 | 106139 | 38779 | 32368179 |
Atrial fibrillation | 209.04 | 11.94 | 846 | 105722 | 115858 | 32291100 |
Pyrexia | 204.72 | 11.94 | 468 | 106100 | 319500 | 32087458 |
Fall | 201.37 | 11.94 | 1213 | 105355 | 194988 | 32211970 |
Incorrect dose administered | 193.57 | 11.94 | 383 | 106185 | 34645 | 32372313 |
Drug abuse | 189.20 | 11.94 | 21 | 106547 | 80222 | 32326736 |
Shock haemorrhagic | 185.99 | 11.94 | 201 | 106367 | 10444 | 32396514 |
Labelled drug-drug interaction medication error | 183.75 | 11.94 | 215 | 106353 | 12198 | 32394760 |
Cerebellar haemorrhage | 173.25 | 11.94 | 89 | 106479 | 1419 | 32405539 |
Cerebral haematoma | 170.71 | 11.94 | 135 | 106433 | 4676 | 32402282 |
Thalamus haemorrhage | 168.42 | 11.94 | 77 | 106491 | 936 | 32406022 |
Intraventricular haemorrhage | 162.36 | 11.94 | 111 | 106457 | 3059 | 32403899 |
Embolic cerebral infarction | 162.13 | 11.94 | 67 | 106501 | 625 | 32406333 |
Haemorrhoidal haemorrhage | 162.08 | 11.94 | 112 | 106456 | 3142 | 32403816 |
Contusion | 154.56 | 11.94 | 340 | 106228 | 33128 | 32373830 |
Febrile neutropenia | 154.35 | 11.94 | 101 | 106467 | 119465 | 32287493 |
Subarachnoid haemorrhage | 145.31 | 11.94 | 175 | 106393 | 10236 | 32396722 |
Procedural haemorrhage | 143.82 | 11.94 | 94 | 106474 | 2399 | 32404559 |
Gastrointestinal vascular malformation haemorrhagic | 133.89 | 11.94 | 56 | 106512 | 540 | 32406418 |
Haematemesis | 133.60 | 11.94 | 286 | 106282 | 27349 | 32379609 |
Cerebral artery embolism | 132.41 | 11.94 | 64 | 106504 | 889 | 32406069 |
International normalised ratio increased | 129.39 | 11.94 | 404 | 106164 | 48631 | 32358327 |
Wound haemorrhage | 124.66 | 11.94 | 79 | 106489 | 1909 | 32405049 |
Faeces discoloured | 124.14 | 11.94 | 195 | 106373 | 14682 | 32392276 |
Hemiplegia | 119.18 | 11.94 | 131 | 106437 | 6937 | 32400021 |
Creatinine renal clearance decreased | 118.64 | 11.94 | 96 | 106472 | 3438 | 32403520 |
Gastric ulcer haemorrhage | 114.31 | 11.94 | 115 | 106453 | 5492 | 32401466 |
Neutropenia | 114.21 | 11.94 | 181 | 106387 | 141994 | 32264964 |
Foetal exposure during pregnancy | 113.96 | 11.94 | 5 | 106563 | 41296 | 32365662 |
Cardioversion | 113.86 | 11.94 | 57 | 106511 | 858 | 32406100 |
Hemiparesis | 111.88 | 11.94 | 191 | 106377 | 15416 | 32391542 |
Cardiac tamponade | 108.84 | 11.94 | 107 | 106461 | 4968 | 32401990 |
Iron deficiency anaemia | 108.40 | 11.94 | 146 | 106422 | 9555 | 32397403 |
Subcutaneous haematoma | 103.51 | 11.94 | 55 | 106513 | 943 | 32406015 |
Mouth haemorrhage | 103.44 | 11.94 | 106 | 106462 | 5175 | 32401783 |
Depression | 102.62 | 11.94 | 100 | 106468 | 96960 | 32309998 |
Retroperitoneal haemorrhage | 101.72 | 11.94 | 80 | 106488 | 2748 | 32404210 |
Haemorrhagic transformation stroke | 100.54 | 11.94 | 60 | 106508 | 1298 | 32405660 |
Intracardiac thrombus | 94.33 | 11.94 | 73 | 106495 | 2448 | 32404510 |
Sepsis | 92.82 | 11.94 | 243 | 106325 | 158591 | 32248367 |
Haemorrhage urinary tract | 90.60 | 11.94 | 61 | 106507 | 1638 | 32405320 |
Muscle haemorrhage | 87.34 | 11.94 | 84 | 106484 | 3795 | 32403163 |
Subdural haemorrhage | 86.52 | 11.94 | 75 | 106493 | 2958 | 32404000 |
Anxiety | 85.11 | 11.94 | 114 | 106454 | 95891 | 32311067 |
High frequency ablation | 81.29 | 11.94 | 28 | 106540 | 148 | 32406810 |
Splenic rupture | 81.22 | 11.94 | 56 | 106512 | 1565 | 32405393 |
Cerebral ventricular rupture | 80.07 | 11.94 | 28 | 106540 | 156 | 32406802 |
Drug hypersensitivity | 79.47 | 11.94 | 74 | 106494 | 73326 | 32333632 |
Condition aggravated | 78.66 | 11.94 | 255 | 106313 | 155406 | 32251552 |
Anticoagulation drug level increased | 77.98 | 11.94 | 37 | 106531 | 492 | 32406466 |
Microcytic anaemia | 76.26 | 11.94 | 61 | 106507 | 2148 | 32404810 |
Aphasia | 75.92 | 11.94 | 193 | 106375 | 20635 | 32386323 |
Abdominal wall haematoma | 75.25 | 11.94 | 55 | 106513 | 1689 | 32405269 |
Disease progression | 75.12 | 11.94 | 105 | 106463 | 86757 | 32320201 |
Traumatic intracranial haemorrhage | 74.75 | 11.94 | 39 | 106529 | 643 | 32406315 |
Infusion related reaction | 74.63 | 11.94 | 28 | 106540 | 45571 | 32361387 |
Product prescribing issue | 74.44 | 11.94 | 47 | 106521 | 1128 | 32405830 |
Small intestinal haemorrhage | 74.36 | 11.94 | 59 | 106509 | 2053 | 32404905 |
Pelvic venous thrombosis | 71.49 | 11.94 | 36 | 106532 | 549 | 32406409 |
Renal haemorrhage | 71.48 | 11.94 | 49 | 106519 | 1356 | 32405602 |
Large intestinal haemorrhage | 70.01 | 11.94 | 51 | 106517 | 1558 | 32405400 |
Completed suicide | 69.40 | 11.94 | 123 | 106445 | 92394 | 32314564 |
Haemorrhagic diathesis | 68.69 | 11.94 | 65 | 106503 | 2877 | 32404081 |
Nausea | 67.72 | 11.94 | 699 | 105869 | 320150 | 32086808 |
Agitation | 67.69 | 11.94 | 53 | 106515 | 57183 | 32349775 |
Drug interaction | 67.40 | 11.94 | 1046 | 105522 | 217139 | 32189819 |
Brain stem haemorrhage | 67.02 | 11.94 | 41 | 106527 | 929 | 32406029 |
Traumatic haemorrhage | 66.87 | 11.94 | 37 | 106531 | 690 | 32406268 |
Haemothorax | 66.61 | 11.94 | 72 | 106496 | 3740 | 32403218 |
Occult blood positive | 66.16 | 11.94 | 74 | 106494 | 3995 | 32402963 |
Head injury | 64.71 | 11.94 | 164 | 106404 | 17499 | 32389459 |
Seizure | 64.41 | 11.94 | 154 | 106414 | 103700 | 32303258 |
Rheumatoid arthritis | 63.99 | 11.94 | 33 | 106535 | 44511 | 32362447 |
Post procedural haematoma | 63.42 | 11.94 | 48 | 106520 | 1556 | 32405402 |
Insomnia | 62.08 | 11.94 | 149 | 106419 | 100199 | 32306759 |
Haemorrhage subcutaneous | 61.93 | 11.94 | 56 | 106512 | 2337 | 32404621 |
Pulmonary haemorrhage | 60.82 | 11.94 | 113 | 106455 | 9744 | 32397214 |
Rhabdomyolysis | 59.47 | 11.94 | 80 | 106488 | 67185 | 32339773 |
Neutrophil count decreased | 59.17 | 11.94 | 41 | 106527 | 47098 | 32359860 |
Mucosal inflammation | 59.11 | 11.94 | 18 | 106550 | 33416 | 32373542 |
Tremor | 58.34 | 11.94 | 111 | 106457 | 81166 | 32325792 |
Drug dependence | 58.33 | 11.94 | 5 | 106563 | 23479 | 32383479 |
Prothrombin time prolonged | 57.92 | 11.94 | 110 | 106458 | 9645 | 32397313 |
Pancytopenia | 57.60 | 11.94 | 134 | 106434 | 91101 | 32315857 |
Spinal cord haemorrhage | 57.31 | 11.94 | 26 | 106542 | 310 | 32406648 |
Gastric ulcer | 57.10 | 11.94 | 146 | 106422 | 15663 | 32391295 |
Aggression | 55.37 | 11.94 | 30 | 106538 | 39359 | 32367599 |
Adrenal haemorrhage | 55.32 | 11.94 | 22 | 106546 | 184 | 32406774 |
Gastrointestinal polyp haemorrhage | 55.03 | 11.94 | 25 | 106543 | 299 | 32406659 |
Compartment syndrome | 54.64 | 11.94 | 54 | 106514 | 2523 | 32404435 |
N-terminal prohormone brain natriuretic peptide abnormal | 54.51 | 11.94 | 22 | 106546 | 192 | 32406766 |
Penile haemorrhage | 54.45 | 11.94 | 31 | 106537 | 612 | 32406346 |
Bladder tamponade | 54.38 | 11.94 | 29 | 106539 | 501 | 32406457 |
Overdose | 53.29 | 11.94 | 130 | 106438 | 86947 | 32320011 |
Gastritis erosive | 53.07 | 11.94 | 81 | 106487 | 5946 | 32401012 |
Prostatic haemorrhage | 53.07 | 11.94 | 22 | 106546 | 207 | 32406751 |
Duodenal ulcer haemorrhage | 52.75 | 11.94 | 73 | 106495 | 4901 | 32402057 |
Gastritis haemorrhagic | 52.55 | 11.94 | 40 | 106528 | 1308 | 32405650 |
Product prescribing error | 52.47 | 11.94 | 163 | 106405 | 19554 | 32387404 |
Haemorrhagic cerebral infarction | 52.27 | 11.94 | 33 | 106535 | 792 | 32406166 |
Vomiting | 52.18 | 11.94 | 507 | 106061 | 235050 | 32171908 |
Arterial haemorrhage | 52.01 | 11.94 | 33 | 106535 | 799 | 32406159 |
Psoriasis | 51.70 | 11.94 | 45 | 106523 | 46078 | 32360880 |
Inappropriate schedule of product administration | 51.09 | 11.94 | 290 | 106278 | 45535 | 32361423 |
Somnolence | 51.03 | 11.94 | 172 | 106396 | 103625 | 32303333 |
Aspartate aminotransferase increased | 51.00 | 11.94 | 87 | 106481 | 66342 | 32340616 |
Eye haemorrhage | 50.63 | 11.94 | 64 | 106504 | 3933 | 32403025 |
Blood glucose increased | 50.50 | 11.94 | 85 | 106483 | 65156 | 32341802 |
Multiple organ dysfunction syndrome | 50.47 | 11.94 | 95 | 106473 | 69759 | 32337199 |
Gastrointestinal ulcer haemorrhage | 50.18 | 11.94 | 30 | 106538 | 651 | 32406307 |
Cerebral ischaemia | 49.74 | 11.94 | 81 | 106487 | 6286 | 32400672 |
Death | 49.52 | 11.94 | 920 | 105648 | 381597 | 32025361 |
Bone marrow failure | 49.20 | 11.94 | 19 | 106549 | 30385 | 32376573 |
Peripheral embolism | 49.09 | 11.94 | 34 | 106534 | 957 | 32406001 |
Blood creatine phosphokinase increased | 49.02 | 11.94 | 46 | 106522 | 45430 | 32361528 |
Urinary bladder haemorrhage | 48.69 | 11.94 | 43 | 106525 | 1739 | 32405219 |
Drug withdrawal syndrome | 48.40 | 11.94 | 5 | 106563 | 20226 | 32386732 |
Cytomegalovirus infection | 48.21 | 11.94 | 12 | 106556 | 25452 | 32381506 |
Asthma | 48.18 | 11.94 | 44 | 106524 | 44021 | 32362937 |
Suicidal ideation | 47.96 | 11.94 | 33 | 106535 | 38050 | 32368908 |
Therapeutic response decreased | 47.58 | 11.94 | 13 | 106555 | 25907 | 32381051 |
Hyponatraemia | 47.38 | 11.94 | 109 | 106459 | 74404 | 32332554 |
Deep vein thrombosis postoperative | 47.20 | 11.94 | 11 | 106557 | 6 | 32406952 |
Thrombophlebitis superficial | 47 | 11.94 | 52 | 106516 | 2773 | 32404185 |
Leukopenia | 46.84 | 11.94 | 78 | 106490 | 60044 | 32346914 |
Embolism venous | 46.57 | 11.94 | 38 | 106530 | 1377 | 32405581 |
Urogenital haemorrhage | 46.28 | 11.94 | 26 | 106542 | 500 | 32406458 |
Cerebral ventricle collapse | 45.78 | 11.94 | 15 | 106553 | 66 | 32406892 |
Treatment noncompliance | 45.26 | 11.94 | 193 | 106375 | 27009 | 32379949 |
Haemorrhagic erosive gastritis | 45.23 | 11.94 | 17 | 106551 | 120 | 32406838 |
Pneumonia | 44.85 | 11.94 | 858 | 105710 | 354394 | 32052564 |
Coagulopathy | 44.15 | 11.94 | 153 | 106415 | 19424 | 32387534 |
Hypochromic anaemia | 43.93 | 11.94 | 30 | 106538 | 825 | 32406133 |
Malignant neoplasm progression | 43.59 | 11.94 | 123 | 106445 | 78373 | 32328585 |
White blood cell count increased | 43.32 | 11.94 | 43 | 106525 | 41359 | 32365599 |
Conjunctival haemorrhage | 43.16 | 11.94 | 50 | 106518 | 2805 | 32404153 |
Chills | 42.89 | 11.94 | 123 | 106445 | 77961 | 32328997 |
Skin haemorrhage | 42.64 | 11.94 | 57 | 106511 | 3702 | 32403256 |
Retinal vascular thrombosis | 42.48 | 11.94 | 14 | 106554 | 63 | 32406895 |
Ischaemic cerebral infarction | 42.13 | 11.94 | 32 | 106536 | 1043 | 32405915 |
Alanine aminotransferase increased | 42.10 | 11.94 | 125 | 106443 | 78354 | 32328604 |
Infection | 41.89 | 11.94 | 140 | 106428 | 84575 | 32322383 |
Cerebellar infarction | 41.75 | 11.94 | 42 | 106526 | 2005 | 32404953 |
Psychotic disorder | 41.41 | 11.94 | 12 | 106556 | 23008 | 32383950 |
Pericardial effusion | 41.25 | 11.94 | 167 | 106401 | 22835 | 32384123 |
Splenic haemorrhage | 40.90 | 11.94 | 22 | 106546 | 387 | 32406571 |
Peripheral swelling | 40.79 | 11.94 | 372 | 106196 | 67973 | 32338985 |
Irritability | 40.57 | 11.94 | 15 | 106553 | 24639 | 32382319 |
Ecchymosis | 40.54 | 11.94 | 77 | 106491 | 6751 | 32400207 |
Cerebral mass effect | 40.47 | 11.94 | 29 | 106539 | 863 | 32406095 |
White blood cell count decreased | 40.27 | 11.94 | 158 | 106410 | 91040 | 32315918 |
Cardiac ventricular thrombosis | 40.23 | 11.94 | 29 | 106539 | 871 | 32406087 |
Pain | 40.10 | 11.94 | 407 | 106161 | 187149 | 32219809 |
Vascular stent thrombosis | 39.16 | 11.94 | 45 | 106523 | 2502 | 32404456 |
Hypovolaemic shock | 38.97 | 11.94 | 76 | 106492 | 6796 | 32400162 |
Vitreous haemorrhage | 38.96 | 11.94 | 42 | 106526 | 2175 | 32404783 |
Dehydration | 38.95 | 11.94 | 255 | 106313 | 128703 | 32278255 |
Wound haematoma | 38.83 | 11.94 | 13 | 106555 | 62 | 32406896 |
Retroperitoneal haematoma | 38.75 | 11.94 | 46 | 106522 | 2649 | 32404309 |
Neutrophil count increased | 38.51 | 11.94 | 4 | 106564 | 16110 | 32390848 |
Drug reaction with eosinophilia and systemic symptoms | 38.50 | 11.94 | 30 | 106538 | 32455 | 32374503 |
Venous thrombosis | 38.45 | 11.94 | 52 | 106516 | 3415 | 32403543 |
Vascular pseudoaneurysm | 38.19 | 11.94 | 41 | 106527 | 2113 | 32404845 |
No adverse event | 36.91 | 11.94 | 10 | 106558 | 20043 | 32386915 |
Ear haemorrhage | 36.59 | 11.94 | 28 | 106540 | 923 | 32406035 |
Lymphocyte count decreased | 36.21 | 11.94 | 12 | 106556 | 21107 | 32385851 |
Duodenal ulcer | 36.15 | 11.94 | 95 | 106473 | 10360 | 32396598 |
Pulmonary alveolar haemorrhage | 35.84 | 11.94 | 75 | 106493 | 7054 | 32399904 |
Hypoxia | 35.83 | 11.94 | 73 | 106495 | 52059 | 32354899 |
Activated partial thromboplastin time prolonged | 35.77 | 11.94 | 83 | 106485 | 8372 | 32398586 |
Dizziness | 35.33 | 11.94 | 918 | 105650 | 208700 | 32198258 |
Pancreatitis | 35.12 | 11.94 | 44 | 106524 | 38107 | 32368851 |
Weight decreased | 35.08 | 11.94 | 358 | 106210 | 164460 | 32242498 |
Spontaneous haematoma | 34.95 | 11.94 | 22 | 106546 | 525 | 32406433 |
Anticoagulation drug level decreased | 34.90 | 11.94 | 12 | 106556 | 63 | 32406895 |
Diabetes mellitus | 34.81 | 11.94 | 59 | 106509 | 45114 | 32361844 |
Brain stem infarction | 34.52 | 11.94 | 31 | 106537 | 1282 | 32405676 |
Gastrointestinal angiectasia | 34.49 | 11.94 | 17 | 106551 | 247 | 32406711 |
Peptic ulcer haemorrhage | 34.40 | 11.94 | 21 | 106547 | 474 | 32406484 |
Intestinal haemorrhage | 33.47 | 11.94 | 48 | 106520 | 3331 | 32403627 |
Abnormal behaviour | 33.23 | 11.94 | 23 | 106545 | 26443 | 32380515 |
Splenic haematoma | 33.20 | 11.94 | 15 | 106553 | 177 | 32406781 |
Renal haematoma | 33.19 | 11.94 | 21 | 106547 | 506 | 32406452 |
Drug intolerance | 33.14 | 11.94 | 72 | 106496 | 50163 | 32356795 |
Osteonecrosis | 33.13 | 11.94 | 7 | 106561 | 16615 | 32390343 |
Neurotoxicity | 32.95 | 11.94 | 5 | 106563 | 15065 | 32391893 |
Blood blister | 32.88 | 11.94 | 33 | 106535 | 1571 | 32405387 |
Injection site pain | 32.71 | 11.94 | 36 | 106532 | 33022 | 32373936 |
Incision site haemorrhage | 32.61 | 11.94 | 21 | 106547 | 522 | 32406436 |
Arteriovenous malformation | 32.22 | 11.94 | 23 | 106545 | 680 | 32406278 |
Extra dose administered | 31.76 | 11.94 | 47 | 106521 | 3356 | 32403602 |
Hypophagia | 31.75 | 11.94 | 19 | 106549 | 23604 | 32383354 |
Putamen haemorrhage | 31.43 | 11.94 | 16 | 106552 | 250 | 32406708 |
Cardiac ablation | 31.37 | 11.94 | 22 | 106546 | 632 | 32406326 |
Anticoagulation drug level above therapeutic | 31.35 | 11.94 | 35 | 106533 | 1885 | 32405073 |
Venous thrombosis limb | 31.00 | 11.94 | 35 | 106533 | 1909 | 32405049 |
Aneurysm ruptured | 30.89 | 11.94 | 20 | 106548 | 502 | 32406456 |
Therapy non-responder | 30.75 | 11.94 | 37 | 106531 | 32617 | 32374341 |
Pruritus genital | 30.73 | 11.94 | 21 | 106547 | 578 | 32406380 |
Puncture site haemorrhage | 30.25 | 11.94 | 17 | 106551 | 327 | 32406631 |
Thrombotic stroke | 30.23 | 11.94 | 16 | 106552 | 272 | 32406686 |
Therapeutic procedure | 29.92 | 11.94 | 14 | 106554 | 180 | 32406778 |
Mesenteric haemorrhage | 29.92 | 11.94 | 7 | 106561 | 4 | 32406954 |
Cardiac arrest | 29.90 | 11.94 | 190 | 106378 | 96586 | 32310372 |
Ulcer haemorrhage | 29.87 | 11.94 | 40 | 106528 | 2602 | 32404356 |
Decreased appetite | 29.58 | 11.94 | 361 | 106207 | 160452 | 32246506 |
Haemorrhoids | 29.46 | 11.94 | 101 | 106467 | 12752 | 32394206 |
Renal tubular necrosis | 29.35 | 11.94 | 8 | 106560 | 15970 | 32390988 |
Dyspnoea exertional | 29.06 | 11.94 | 223 | 106345 | 38738 | 32368220 |
Glomerular filtration rate decreased | 28.78 | 11.94 | 100 | 106468 | 12711 | 32394247 |
Fractured coccyx | 28.73 | 11.94 | 13 | 106555 | 154 | 32406804 |
Cardio-respiratory arrest | 28.72 | 11.94 | 91 | 106477 | 55898 | 32351060 |
Anaphylactic reaction | 28.61 | 11.94 | 34 | 106534 | 30138 | 32376820 |
Toxic epidermal necrolysis | 28.48 | 11.94 | 16 | 106552 | 20577 | 32386381 |
Emotional distress | 28.42 | 11.94 | 9 | 106559 | 16297 | 32390661 |
Embolism | 28.37 | 11.94 | 70 | 106498 | 7344 | 32399614 |
Hypersensitivity | 28.16 | 11.94 | 96 | 106472 | 57662 | 32349296 |
Myocardial infarction | 27.97 | 11.94 | 270 | 106298 | 125406 | 32281552 |
Diarrhoea | 27.93 | 11.94 | 948 | 105620 | 363854 | 32043104 |
Sedation | 27.70 | 11.94 | 13 | 106555 | 18513 | 32388445 |
Septic shock | 27.67 | 11.94 | 124 | 106444 | 68865 | 32338093 |
Intentional self-injury | 27.40 | 11.94 | 6 | 106562 | 13894 | 32393064 |
Cardiac failure | 27.25 | 11.94 | 437 | 106131 | 91236 | 32315722 |
Cerebral artery occlusion | 27.20 | 11.94 | 22 | 106546 | 787 | 32406171 |
Confusional state | 27.19 | 11.94 | 319 | 106249 | 142796 | 32264162 |
Stomatitis | 27.08 | 11.94 | 57 | 106511 | 40172 | 32366786 |
Respiratory failure | 27.03 | 11.94 | 223 | 106345 | 106959 | 32299999 |
Anal haemorrhage | 27.03 | 11.94 | 34 | 106534 | 2079 | 32404879 |
Respiratory arrest | 26.96 | 11.94 | 33 | 106535 | 28875 | 32378083 |
Brain natriuretic peptide abnormal | 26.94 | 11.94 | 16 | 106552 | 343 | 32406615 |
Loss of personal independence in daily activities | 26.79 | 11.94 | 29 | 106539 | 26804 | 32380154 |
Colitis | 26.48 | 11.94 | 44 | 106524 | 33907 | 32373051 |
Haematoma muscle | 26.41 | 11.94 | 24 | 106544 | 1008 | 32405950 |
Bleeding varicose vein | 26.31 | 11.94 | 15 | 106553 | 297 | 32406661 |
Therapeutic product effect decreased | 26.29 | 11.94 | 38 | 106530 | 30979 | 32375979 |
Blood thyroid stimulating hormone abnormal | 26.09 | 11.94 | 14 | 106554 | 245 | 32406713 |
Peritonitis | 25.98 | 11.94 | 21 | 106547 | 22309 | 32384649 |
Blood urea increased | 25.94 | 11.94 | 41 | 106527 | 32232 | 32374726 |
Periorbital haemorrhage | 25.86 | 11.94 | 11 | 106557 | 111 | 32406847 |
Penis injury | 25.74 | 11.94 | 14 | 106554 | 252 | 32406706 |
Mesenteric artery thrombosis | 25.73 | 11.94 | 17 | 106551 | 442 | 32406516 |
Peripheral artery occlusion | 25.69 | 11.94 | 29 | 106539 | 1581 | 32405377 |
Post thrombotic syndrome | 25.67 | 11.94 | 12 | 106556 | 154 | 32406804 |
Peritonitis bacterial | 25.45 | 11.94 | 5 | 106563 | 12491 | 32394467 |
Coronary artery disease | 25.35 | 11.94 | 81 | 106487 | 49625 | 32357333 |
Polyp | 25.19 | 11.94 | 43 | 106525 | 3469 | 32403489 |
Osteonecrosis of jaw | 24.95 | 11.94 | 16 | 106552 | 19150 | 32387808 |
Injection site reaction | 24.93 | 11.94 | 4 | 106564 | 11565 | 32395393 |
Pharyngeal haemorrhage | 24.79 | 11.94 | 20 | 106548 | 713 | 32406245 |
Mallory-Weiss syndrome | 24.78 | 11.94 | 27 | 106541 | 1415 | 32405543 |
Aortic aneurysm rupture | 24.75 | 11.94 | 24 | 106544 | 1095 | 32405863 |
Neurologic neglect syndrome | 24.55 | 11.94 | 12 | 106556 | 171 | 32406787 |
Hydrocephalus | 24.54 | 11.94 | 50 | 106518 | 4615 | 32402343 |
Myocardial strain | 24.51 | 11.94 | 10 | 106558 | 90 | 32406868 |
Sinusitis | 24.44 | 11.94 | 52 | 106516 | 36508 | 32370450 |
Constipation | 23.87 | 11.94 | 282 | 106286 | 126091 | 32280867 |
Coagulation test abnormal | 23.84 | 11.94 | 17 | 106551 | 502 | 32406456 |
Hyperglycaemia | 23.72 | 11.94 | 57 | 106511 | 38334 | 32368624 |
Retinal artery occlusion | 23.59 | 11.94 | 29 | 106539 | 1732 | 32405226 |
Respiratory depression | 23.55 | 11.94 | 7 | 106561 | 13204 | 32393754 |
Prescribed underdose | 23.42 | 11.94 | 72 | 106496 | 8587 | 32398371 |
Traumatic haematoma | 23.30 | 11.94 | 20 | 106548 | 778 | 32406180 |
Psoriatic arthropathy | 23.12 | 11.94 | 15 | 106553 | 17845 | 32389113 |
Pulmonary arterial pressure abnormal | 23.04 | 11.94 | 12 | 106556 | 197 | 32406761 |
Abdominal pain | 23.04 | 11.94 | 348 | 106220 | 149181 | 32257777 |
Delirium | 23.01 | 11.94 | 71 | 106497 | 43975 | 32362983 |
Aspergillus infection | 22.81 | 11.94 | 5 | 106563 | 11569 | 32395389 |
Therapeutic product effect incomplete | 22.78 | 11.94 | 65 | 106503 | 41276 | 32365682 |
Intentional product misuse | 22.69 | 11.94 | 53 | 106515 | 35998 | 32370960 |
Paranoia | 22.68 | 11.94 | 4 | 106564 | 10795 | 32396163 |
Hospitalisation | 22.67 | 11.94 | 253 | 106315 | 48718 | 32358240 |
Product administration error | 22.34 | 11.94 | 106 | 106462 | 15519 | 32391439 |
Dental care | 22.29 | 11.94 | 13 | 106555 | 269 | 32406689 |
Hepatic function abnormal | 22.22 | 11.94 | 74 | 106494 | 44766 | 32362192 |
Dystonia | 22.17 | 11.94 | 4 | 106564 | 10619 | 32396339 |
Staphylococcal infection | 21.80 | 11.94 | 46 | 106522 | 32393 | 32374565 |
Purpura | 21.80 | 11.94 | 80 | 106488 | 10445 | 32396513 |
Pancreatitis acute | 21.71 | 11.94 | 35 | 106533 | 27300 | 32379658 |
Back pain | 21.68 | 11.94 | 246 | 106322 | 110807 | 32296151 |
Diabetes mellitus inadequate control | 21.62 | 11.94 | 9 | 106559 | 13759 | 32393199 |
Herpes zoster | 21.62 | 11.94 | 46 | 106522 | 32295 | 32374663 |
Product label issue | 21.53 | 11.94 | 12 | 106556 | 227 | 32406731 |
Haemorrhagic infarction | 21.51 | 11.94 | 15 | 106553 | 427 | 32406531 |
Diverticulitis intestinal haemorrhagic | 21.50 | 11.94 | 14 | 106554 | 355 | 32406603 |
Oesophageal haemorrhage | 21.44 | 11.94 | 23 | 106545 | 1184 | 32405774 |
Arthralgia | 21.35 | 11.94 | 350 | 106218 | 148098 | 32258860 |
Peripheral ischaemia | 21.33 | 11.94 | 54 | 106514 | 5757 | 32401201 |
Stress | 21.29 | 11.94 | 28 | 106540 | 23754 | 32383204 |
Cardiac failure chronic | 21.28 | 11.94 | 62 | 106506 | 7178 | 32399780 |
Phlebitis deep | 21.17 | 11.94 | 6 | 106562 | 14 | 32406944 |
Acute myeloid leukaemia | 21.13 | 11.94 | 19 | 106549 | 19155 | 32387803 |
Platelet dysfunction | 21.07 | 11.94 | 12 | 106556 | 237 | 32406721 |
Renal infarct | 21.05 | 11.94 | 23 | 106545 | 1209 | 32405749 |
Hyperkalaemia | 20.99 | 11.94 | 138 | 106430 | 69612 | 32337346 |
Hepatitis C | 20.97 | 11.94 | 9 | 106559 | 13509 | 32393449 |
Hallucination | 20.84 | 11.94 | 95 | 106473 | 52524 | 32354434 |
Synovitis | 20.84 | 11.94 | 5 | 106563 | 10873 | 32396085 |
Palmar-plantar erythrodysaesthesia syndrome | 20.70 | 11.94 | 13 | 106555 | 15736 | 32391222 |
Candida infection | 20.57 | 11.94 | 15 | 106553 | 16788 | 32390170 |
Electrocardiogram QRS complex abnormal | 20.55 | 11.94 | 13 | 106555 | 313 | 32406645 |
Intra-abdominal haematoma | 20.54 | 11.94 | 24 | 106544 | 1359 | 32405599 |
Hyperhomocysteinaemia | 20.52 | 11.94 | 11 | 106557 | 192 | 32406766 |
Large intestine polyp | 20.50 | 11.94 | 61 | 106507 | 7145 | 32399813 |
Haematospermia | 20.44 | 11.94 | 14 | 106554 | 387 | 32406571 |
Neutropenic sepsis | 20.44 | 11.94 | 8 | 106560 | 12691 | 32394267 |
Brain compression | 20.37 | 11.94 | 11 | 106557 | 195 | 32406763 |
Lymphopenia | 20.32 | 11.94 | 11 | 106557 | 14445 | 32392513 |
Hepatotoxicity | 20.32 | 11.94 | 20 | 106548 | 19317 | 32387641 |
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits | 20.17 | 11.94 | 5 | 106563 | 5 | 32406953 |
Oxygen saturation increased | 20.13 | 11.94 | 12 | 106556 | 259 | 32406699 |
Traumatic haemothorax | 20.05 | 11.94 | 12 | 106556 | 261 | 32406697 |
Angioedema | 20.03 | 11.94 | 57 | 106511 | 36232 | 32370726 |
Colitis ulcerative | 19.88 | 11.94 | 16 | 106552 | 17035 | 32389923 |
Bleeding time prolonged | 19.88 | 11.94 | 17 | 106551 | 658 | 32406300 |
Accidental exposure to product | 19.85 | 11.94 | 6 | 106562 | 11196 | 32395762 |
Brain herniation | 19.78 | 11.94 | 41 | 106527 | 3830 | 32403128 |
Haemoperitoneum | 19.78 | 11.94 | 26 | 106542 | 1661 | 32405297 |
Hypercoagulation | 19.72 | 11.94 | 22 | 106546 | 1184 | 32405774 |
Multiple sclerosis relapse | 19.67 | 11.94 | 7 | 106561 | 11774 | 32395184 |
Encephalopathy | 19.51 | 11.94 | 53 | 106515 | 34204 | 32372754 |
Hypertension | 19.48 | 11.94 | 309 | 106259 | 131441 | 32275517 |
Postoperative thrombosis | 19.39 | 11.94 | 6 | 106562 | 21 | 32406937 |
Intra-abdominal haemorrhage | 19.34 | 11.94 | 30 | 106538 | 2233 | 32404725 |
Vena cava thrombosis | 19.33 | 11.94 | 21 | 106547 | 1097 | 32405861 |
Carotid artery aneurysm | 19.31 | 11.94 | 7 | 106561 | 44 | 32406914 |
Cholestasis | 19.31 | 11.94 | 37 | 106531 | 26996 | 32379962 |
Catheter site haemorrhage | 19.22 | 11.94 | 30 | 106538 | 2245 | 32404713 |
Bladder neoplasm | 19.15 | 11.94 | 23 | 106545 | 1341 | 32405617 |
Progressive multifocal leukoencephalopathy | 19.02 | 11.94 | 4 | 106564 | 9527 | 32397431 |
Fatigue | 18.98 | 11.94 | 948 | 105620 | 349753 | 32057205 |
Pulmonary arterial hypertension | 18.97 | 11.94 | 73 | 106495 | 9748 | 32397210 |
C-reactive protein increased | 18.96 | 11.94 | 87 | 106481 | 48015 | 32358943 |
Coagulation factor X level increased | 18.90 | 11.94 | 4 | 106564 | 0 | 32406958 |
Haematotympanum | 18.90 | 11.94 | 4 | 106564 | 0 | 32406958 |
Peripheral artery thrombosis | 18.83 | 11.94 | 30 | 106538 | 2285 | 32404673 |
Hypertriglyceridaemia | 18.82 | 11.94 | 3 | 106565 | 8716 | 32398242 |
Dysphagia | 18.82 | 11.94 | 121 | 106447 | 61355 | 32345603 |
Hypocalcaemia | 18.80 | 11.94 | 29 | 106539 | 23025 | 32383933 |
Anastomotic ulcer haemorrhage | 18.77 | 11.94 | 6 | 106562 | 24 | 32406934 |
Restlessness | 18.71 | 11.94 | 33 | 106535 | 24848 | 32382110 |
Post-traumatic amnestic disorder | 18.67 | 11.94 | 7 | 106561 | 49 | 32406909 |
Influenza like illness | 18.65 | 11.94 | 38 | 106530 | 27102 | 32379856 |
Drug resistance | 18.62 | 11.94 | 29 | 106539 | 22936 | 32384022 |
Syncope | 18.58 | 11.94 | 406 | 106162 | 89718 | 32317240 |
Blood bilirubin increased | 18.54 | 11.94 | 65 | 106503 | 38719 | 32368239 |
Neuroleptic malignant syndrome | 18.49 | 11.94 | 18 | 106550 | 17477 | 32389481 |
Lung diffusion disorder | 18.45 | 11.94 | 8 | 106560 | 85 | 32406873 |
Fear | 18.43 | 11.94 | 7 | 106561 | 11312 | 32395646 |
Bronchopulmonary aspergillosis | 18.40 | 11.94 | 11 | 106557 | 13676 | 32393282 |
Limb injury | 18.40 | 11.94 | 74 | 106494 | 10085 | 32396873 |
Anger | 18.35 | 11.94 | 8 | 106560 | 11896 | 32395062 |
Ill-defined disorder | 18.31 | 11.94 | 8 | 106560 | 11881 | 32395077 |
Metabolic acidosis | 18.28 | 11.94 | 70 | 106498 | 40629 | 32366329 |
Arterial thrombosis | 18.27 | 11.94 | 24 | 106544 | 1532 | 32405426 |
Contraindicated product administered | 18.23 | 11.94 | 116 | 106452 | 18960 | 32387998 |
Pneumocystis jirovecii pneumonia | 18.17 | 11.94 | 21 | 106547 | 18849 | 32388109 |
Skin ulcer haemorrhage | 18.06 | 11.94 | 9 | 106559 | 134 | 32406824 |
Cytokine release syndrome | 18.03 | 11.94 | 11 | 106557 | 13524 | 32393434 |
Malnutrition | 18.02 | 11.94 | 9 | 106559 | 12369 | 32394589 |
Tachycardia | 17.97 | 11.94 | 169 | 106399 | 78919 | 32328039 |
Blood triglycerides increased | 17.96 | 11.94 | 13 | 106555 | 14606 | 32392352 |
Hepatic steatosis | 17.76 | 11.94 | 16 | 106552 | 16117 | 32390841 |
Renal failure | 17.74 | 11.94 | 322 | 106246 | 134156 | 32272802 |
Embolism arterial | 17.71 | 11.94 | 15 | 106553 | 573 | 32406385 |
Hypersensitivity vasculitis | 17.67 | 11.94 | 38 | 106530 | 3643 | 32403315 |
Duodenitis haemorrhagic | 17.59 | 11.94 | 8 | 106560 | 96 | 32406862 |
Extradural haematoma | 17.58 | 11.94 | 21 | 106547 | 1217 | 32405741 |
Respiratory distress | 17.58 | 11.94 | 58 | 106510 | 35188 | 32371770 |
Tumour haemorrhage | 17.55 | 11.94 | 32 | 106536 | 2719 | 32404239 |
Lacunar stroke | 17.49 | 11.94 | 9 | 106559 | 144 | 32406814 |
N-terminal prohormone brain natriuretic peptide increased | 17.45 | 11.94 | 27 | 106541 | 2005 | 32404953 |
Hypernatraemia | 17.40 | 11.94 | 3 | 106565 | 8230 | 32398728 |
Withdrawal syndrome | 17.37 | 11.94 | 9 | 106559 | 12113 | 32394845 |
Neuropathy peripheral | 17.27 | 11.94 | 165 | 106403 | 76817 | 32330141 |
Blood lactate dehydrogenase increased | 17.24 | 11.94 | 28 | 106540 | 21777 | 32385181 |
Injection site swelling | 17.23 | 11.94 | 5 | 106563 | 9579 | 32397379 |
Diabetic ketoacidosis | 17.22 | 11.94 | 20 | 106548 | 17912 | 32389046 |
Disseminated intravascular coagulation | 17.19 | 11.94 | 31 | 106537 | 23145 | 32383813 |
Hypoglycaemia | 17.18 | 11.94 | 106 | 106462 | 54276 | 32352682 |
Acidosis | 17.18 | 11.94 | 7 | 106561 | 10839 | 32396119 |
Mental status changes | 17.18 | 11.94 | 66 | 106502 | 38271 | 32368687 |
Lymphoma | 17.06 | 11.94 | 7 | 106561 | 10793 | 32396165 |
Erythema | 17.04 | 11.94 | 182 | 106386 | 82923 | 32324035 |
International normalised ratio abnormal | 17 | 11.94 | 35 | 106533 | 3254 | 32403704 |
Chronic gastrointestinal bleeding | 16.99 | 11.94 | 11 | 106557 | 276 | 32406682 |
Surgery | 16.95 | 11.94 | 84 | 106484 | 12515 | 32394443 |
Haemodilution | 16.93 | 11.94 | 6 | 106562 | 35 | 32406923 |
Nephropathy toxic | 16.93 | 11.94 | 9 | 106559 | 11937 | 32395021 |
Adverse event | 16.89 | 11.94 | 102 | 106466 | 16370 | 32390588 |
Ascites | 16.87 | 11.94 | 71 | 106497 | 40120 | 32366838 |
Metastases to bone | 16.82 | 11.94 | 7 | 106561 | 10703 | 32396255 |
Spinal cord haematoma | 16.82 | 11.94 | 8 | 106560 | 107 | 32406851 |
Supine hypertension | 16.69 | 11.94 | 12 | 106556 | 359 | 32406599 |
Tongue haemorrhage | 16.63 | 11.94 | 14 | 106554 | 530 | 32406428 |
Perforated ulcer | 16.60 | 11.94 | 9 | 106559 | 161 | 32406797 |
Night sweats | 16.49 | 11.94 | 17 | 106551 | 16071 | 32390887 |
Poisoning | 16.42 | 11.94 | 8 | 106560 | 11150 | 32395808 |
Presyncope | 16.41 | 11.94 | 105 | 106463 | 17196 | 32389762 |
Vascular graft thrombosis | 16.40 | 11.94 | 9 | 106559 | 165 | 32406793 |
Suicide attempt | 16.40 | 11.94 | 67 | 106501 | 38177 | 32368781 |
Cerebral amyloid angiopathy | 16.31 | 11.94 | 8 | 106560 | 115 | 32406843 |
Dyskinesia | 16.26 | 11.94 | 33 | 106535 | 23570 | 32383388 |
Pulmonary endarterectomy | 16.25 | 11.94 | 7 | 106561 | 73 | 32406885 |
Hypercalcaemia | 16.25 | 11.94 | 13 | 106555 | 13881 | 32393077 |
Therapeutic product ineffective | 16.17 | 11.94 | 15 | 106553 | 647 | 32406311 |
Subarachnoid haematoma | 16.17 | 11.94 | 7 | 106561 | 74 | 32406884 |
Gout | 16.15 | 11.94 | 111 | 106457 | 18617 | 32388341 |
Ureteric haemorrhage | 16.12 | 11.94 | 8 | 106560 | 118 | 32406840 |
Hepatic encephalopathy | 16.12 | 11.94 | 15 | 106553 | 14880 | 32392078 |
Facial paresis | 16.11 | 11.94 | 32 | 106536 | 2899 | 32404059 |
Occult blood | 16.08 | 11.94 | 13 | 106555 | 465 | 32406493 |
Myocarditis | 16.03 | 11.94 | 9 | 106559 | 11581 | 32395377 |
Depressed level of consciousness | 16.03 | 11.94 | 74 | 106494 | 40773 | 32366185 |
Rhinorrhoea | 15.95 | 11.94 | 32 | 106536 | 22954 | 32384004 |
Labelled drug-disease interaction medication error | 15.89 | 11.94 | 8 | 106560 | 122 | 32406836 |
Biopsy prostate | 15.84 | 11.94 | 5 | 106563 | 19 | 32406939 |
Basilar artery thrombosis | 15.79 | 11.94 | 9 | 106559 | 178 | 32406780 |
Pseudomonas infection | 15.78 | 11.94 | 10 | 106558 | 12046 | 32394912 |
Renal embolism | 15.77 | 11.94 | 8 | 106560 | 124 | 32406834 |
Oral candidiasis | 15.71 | 11.94 | 10 | 106558 | 12017 | 32394941 |
Post procedural haematuria | 15.71 | 11.94 | 9 | 106559 | 180 | 32406778 |
Implant site haematoma | 15.69 | 11.94 | 7 | 106561 | 80 | 32406878 |
Vascular access site occlusion | 15.65 | 11.94 | 6 | 106562 | 45 | 32406913 |
Cyanosis | 15.64 | 11.94 | 11 | 106557 | 12542 | 32394416 |
Serotonin syndrome | 15.63 | 11.94 | 24 | 106544 | 19093 | 32387865 |
Mania | 15.61 | 11.94 | 6 | 106562 | 9626 | 32397332 |
Platelet count decreased | 15.55 | 11.94 | 273 | 106295 | 114318 | 32292640 |
Hemiataxia | 15.54 | 11.94 | 6 | 106562 | 46 | 32406912 |
Cardiac valve replacement complication | 15.43 | 11.94 | 6 | 106562 | 47 | 32406911 |
Plasma cell myeloma | 15.38 | 11.94 | 118 | 106450 | 57496 | 32349462 |
Lymphadenopathy | 15.35 | 11.94 | 42 | 106526 | 27040 | 32379918 |
Subclavian vein thrombosis | 15.33 | 11.94 | 17 | 106551 | 909 | 32406049 |
Intestinal perforation | 15.29 | 11.94 | 5 | 106563 | 8870 | 32398088 |
Hypophosphataemia | 15.29 | 11.94 | 5 | 106563 | 8870 | 32398088 |
Anaphylactic shock | 15.28 | 11.94 | 16 | 106552 | 15018 | 32391940 |
Splenomegaly | 15.18 | 11.94 | 15 | 106553 | 14462 | 32392496 |
Cytopenia | 15.14 | 11.94 | 7 | 106561 | 10057 | 32396901 |
Carotid artery occlusion | 15.12 | 11.94 | 26 | 106542 | 2110 | 32404848 |
Upper respiratory tract infection | 15.04 | 11.94 | 48 | 106520 | 29425 | 32377533 |
Abdominal wall haemorrhage | 15.03 | 11.94 | 7 | 106561 | 89 | 32406869 |
Blood pressure increased | 15.00 | 11.94 | 177 | 106391 | 79177 | 32327781 |
Conjunctivitis | 14.88 | 11.94 | 5 | 106563 | 8721 | 32398237 |
Uterine haemorrhage | 14.87 | 11.94 | 4 | 106564 | 7 | 32406951 |
Subclavian artery thrombosis | 14.87 | 11.94 | 4 | 106564 | 7 | 32406951 |
Post procedural oedema | 14.87 | 11.94 | 4 | 106564 | 7 | 32406951 |
Potentiating drug interaction | 14.83 | 11.94 | 43 | 106525 | 4965 | 32401993 |
Blood potassium increased | 14.82 | 11.94 | 20 | 106548 | 16784 | 32390174 |
Retinal artery thrombosis | 14.74 | 11.94 | 5 | 106563 | 25 | 32406933 |
Cardiac vein perforation | 14.74 | 11.94 | 5 | 106563 | 25 | 32406933 |
Klebsiella infection | 14.74 | 11.94 | 4 | 106564 | 8008 | 32398950 |
Mobility decreased | 14.69 | 11.94 | 46 | 106522 | 28363 | 32378595 |
Myelodysplastic syndrome | 14.68 | 11.94 | 27 | 106541 | 20011 | 32386947 |
Polyneuropathy | 14.67 | 11.94 | 13 | 106555 | 13202 | 32393756 |
Vocal cord inflammation | 14.61 | 11.94 | 6 | 106562 | 55 | 32406903 |
Idiopathic interstitial pneumonia | 14.56 | 11.94 | 8 | 106560 | 147 | 32406811 |
Small intestinal obstruction | 14.55 | 11.94 | 15 | 106553 | 14181 | 32392777 |
Melanaemia | 14.53 | 11.94 | 4 | 106564 | 8 | 32406950 |
Cardiac assistance device user | 14.53 | 11.94 | 4 | 106564 | 8 | 32406950 |
Hypertrophic osteoarthropathy | 14.50 | 11.94 | 7 | 106561 | 97 | 32406861 |
Renal injury | 14.45 | 11.94 | 11 | 106557 | 12044 | 32394914 |
Gastrointestinal angiodysplasia | 14.43 | 11.94 | 14 | 106554 | 639 | 32406319 |
Delusion | 14.43 | 11.94 | 13 | 106555 | 13095 | 32393863 |
Varicose vein ruptured | 14.43 | 11.94 | 5 | 106563 | 27 | 32406931 |
Transfusion | 14.40 | 11.94 | 57 | 106511 | 7711 | 32399247 |
Gastrointestinal arteriovenous malformation | 14.34 | 11.94 | 11 | 106557 | 364 | 32406594 |
Lung infiltration | 14.29 | 11.94 | 13 | 106555 | 13035 | 32393923 |
Electrocardiogram QT prolonged | 14.29 | 11.94 | 74 | 106494 | 39567 | 32367391 |
Skin exfoliation | 14.27 | 11.94 | 39 | 106529 | 25118 | 32381840 |
Intentional overdose | 14.25 | 11.94 | 79 | 106489 | 41522 | 32365436 |
Tumour lysis syndrome | 14.21 | 11.94 | 16 | 106552 | 14531 | 32392427 |
Thalamic infarction | 14.20 | 11.94 | 14 | 106554 | 652 | 32406306 |
Aortic surgery | 14.17 | 11.94 | 3 | 106565 | 0 | 32406958 |
Phlebectomy | 14.17 | 11.94 | 3 | 106565 | 0 | 32406958 |
Prostatic varices | 14.17 | 11.94 | 3 | 106565 | 0 | 32406958 |
Peripheral arterial occlusive disease | 14.09 | 11.94 | 46 | 106522 | 5663 | 32401295 |
Visual acuity reduced | 14.08 | 11.94 | 20 | 106548 | 16425 | 32390533 |
Cerebral microhaemorrhage | 13.98 | 11.94 | 6 | 106562 | 62 | 32406896 |
Thrombophlebitis | 13.93 | 11.94 | 31 | 106537 | 3041 | 32403917 |
Atrial septal defect | 13.91 | 11.94 | 3 | 106565 | 7022 | 32399936 |
Mediastinal haematoma | 13.83 | 11.94 | 7 | 106561 | 108 | 32406850 |
Hepatic cytolysis | 13.83 | 11.94 | 5 | 106563 | 8328 | 32398630 |
Nasopharyngitis | 13.77 | 11.94 | 138 | 106430 | 63649 | 32343309 |
Body temperature increased | 13.72 | 11.94 | 19 | 106549 | 15772 | 32391186 |
Multiple sclerosis | 13.72 | 11.94 | 4 | 106564 | 7640 | 32399318 |
Intentional product use issue | 13.48 | 11.94 | 82 | 106486 | 42129 | 32364829 |
Left ventricular dilatation | 13.43 | 11.94 | 14 | 106554 | 697 | 32406261 |
Renal vein thrombosis | 13.33 | 11.94 | 8 | 106560 | 175 | 32406783 |
Tuberculosis | 13.24 | 11.94 | 6 | 106562 | 8723 | 32398235 |
Disorganised speech | 13.13 | 11.94 | 14 | 106554 | 716 | 32406242 |
Blood glucose decreased | 13.10 | 11.94 | 15 | 106553 | 13519 | 32393439 |
Dose calculation error | 13.10 | 11.94 | 5 | 106563 | 37 | 32406921 |
Hyperlipidaemia | 13.08 | 11.94 | 17 | 106551 | 14494 | 32392464 |
Cytomegalovirus viraemia | 13.07 | 11.94 | 3 | 106565 | 6724 | 32400234 |
Generalised oedema | 13.01 | 11.94 | 13 | 106555 | 12470 | 32394488 |
Vision blurred | 13 | 11.94 | 88 | 106480 | 44098 | 32362860 |
Aplastic anaemia | 12.97 | 11.94 | 4 | 106564 | 7369 | 32399589 |
Hyperhidrosis | 12.97 | 11.94 | 160 | 106408 | 71008 | 32335950 |
Eye pain | 12.92 | 11.94 | 14 | 106554 | 12934 | 32394024 |
Hyperbilirubinaemia | 12.89 | 11.94 | 24 | 106544 | 17706 | 32389252 |
Subcapsular renal haematoma | 12.88 | 11.94 | 11 | 106557 | 425 | 32406533 |
Gravitational oedema | 12.81 | 11.94 | 13 | 106555 | 627 | 32406331 |
Myopathy | 12.78 | 11.94 | 11 | 106557 | 11330 | 32395628 |
Macular ischaemia | 12.77 | 11.94 | 6 | 106562 | 78 | 32406880 |
Vascular rupture | 12.71 | 11.94 | 8 | 106560 | 191 | 32406767 |
Vascular graft occlusion | 12.66 | 11.94 | 13 | 106555 | 636 | 32406322 |
Dialysis | 12.66 | 11.94 | 11 | 106557 | 11277 | 32395681 |
Fungal infection | 12.62 | 11.94 | 19 | 106549 | 15236 | 32391722 |
Thyroiditis | 12.59 | 11.94 | 23 | 106545 | 1957 | 32405001 |
Myositis | 12.54 | 11.94 | 11 | 106557 | 11224 | 32395734 |
Monoplegia | 12.51 | 11.94 | 20 | 106548 | 1528 | 32405430 |
Antiphospholipid syndrome | 12.49 | 11.94 | 11 | 106557 | 443 | 32406515 |
Cough | 12.45 | 11.94 | 353 | 106215 | 138464 | 32268494 |
Weight increased | 12.43 | 11.94 | 196 | 106372 | 83467 | 32323491 |
Injection site erythema | 12.40 | 11.94 | 18 | 106550 | 14650 | 32392308 |
Stiff person syndrome | 12.35 | 11.94 | 7 | 106561 | 137 | 32406821 |
Urethral haemorrhage | 12.33 | 11.94 | 11 | 106557 | 451 | 32406507 |
Hydronephrosis | 12.32 | 11.94 | 8 | 106560 | 9515 | 32397443 |
Ocular retrobulbar haemorrhage | 12.32 | 11.94 | 4 | 106564 | 17 | 32406941 |
Factor V Leiden mutation | 12.32 | 11.94 | 4 | 106564 | 17 | 32406941 |
Blood calcium decreased | 12.28 | 11.94 | 9 | 106559 | 10048 | 32396910 |
Depressed mood | 12.25 | 11.94 | 26 | 106542 | 18274 | 32388684 |
Paresis cranial nerve | 12.25 | 11.94 | 6 | 106562 | 86 | 32406872 |
Pollakiuria | 12.24 | 11.94 | 27 | 106541 | 18717 | 32388241 |
Thrombotic microangiopathy | 12.23 | 11.94 | 8 | 106560 | 9474 | 32397484 |
Tonsillar ulcer | 12.21 | 11.94 | 8 | 106560 | 205 | 32406753 |
Sinus tachycardia | 12.13 | 11.94 | 22 | 106546 | 16392 | 32390566 |
Feeling abnormal | 12.11 | 11.94 | 133 | 106435 | 60290 | 32346668 |
Protein C deficiency | 12.10 | 11.94 | 3 | 106565 | 3 | 32406955 |
Severe invasive streptococcal infection | 12.10 | 11.94 | 3 | 106565 | 3 | 32406955 |
Anal fissure haemorrhage | 12.10 | 11.94 | 3 | 106565 | 3 | 32406955 |
Echocardiogram | 12.10 | 11.94 | 3 | 106565 | 3 | 32406955 |
Urinary incontinence | 12.08 | 11.94 | 26 | 106542 | 18181 | 32388777 |
Ventricle rupture | 12.07 | 11.94 | 5 | 106563 | 47 | 32406911 |
Brief psychotic disorder with marked stressors | 11.97 | 11.94 | 8 | 106560 | 212 | 32406746 |
Post procedural pulmonary embolism | 11.96 | 11.94 | 4 | 106564 | 19 | 32406939 |
Haematoma infection | 11.96 | 11.94 | 16 | 106552 | 1040 | 32405918 |
Source | Code | Description |
---|---|---|
ATC | B01AF01 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Direct factor Xa inhibitors |
MeSH PA | D000925 | Anticoagulants |
MeSH PA | D000991 | Antithrombins |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D065427 | Factor Xa Inhibitors |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D011480 | Protease Inhibitors |
MeSH PA | D015842 | Serine Proteinase Inhibitors |
FDA MoA | N0000175635 | Factor Xa Inhibitors |
FDA EPC | N0000175637 | Factor Xa Inhibitor |
CHEBI has role | CHEBI:50249 | anticoagulante |
CHEBI has role | CHEBI:68581 | coagulation factor Xa inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Nonvalvular atrial fibrillation | indication | 49436004 | DOID:0060224 |
Prevention of pulmonary embolism | indication | 59282003 | DOID:9477 |
Pulmonary embolism | indication | 59282003 | DOID:9477 |
Deep venous thrombosis | indication | 128053003 | |
Prevention of stroke caused by a clot in a blood vessel in the brain | indication | 135875009 | |
Prevention of systemic embolism caused by a clot in a blood vessel | indication | 414086009 | |
Prevention of venous thromboembolism from re-occuring | indication | 429098002 | |
Prevention of venous thromboembolism in undergoing surgery | indication | 429098002 | |
Prevention of deep vein thrombosis | indication | 439993001 | |
Prevention of atherothrombotic events at high risk of ischaemic events | indication | ||
Prevention of atherothrombotic events after an acute coronary syndrome | indication | ||
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Local anesthetic intrathecal block | contraindication | 231249005 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Procedure on spine | contraindication | 238181003 | |
Lumbar puncture | contraindication | 277762005 | |
Significant Bleeding | contraindication | ||
Placement of Epidural Catheter | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.89 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 7157456 | Aug. 28, 2024 | TREATMENT OF DEEP VEIN THROMBOSIS (DVT) |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 7157456 | Aug. 28, 2024 | TREATMENT OF PULMONARY EMBOLISM (PE) |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 7157456 | Aug. 28, 2024 | TREATMENT OF DEEP VEIN THROMBOSIS (DVT) |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 7157456 | Aug. 28, 2024 | TREATMENT OF PULMONARY EMBOLISM (PE) |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 7157456 | Aug. 28, 2024 | TREATMENT OF DEEP VEIN THROMBOSIS (DVT) |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 7157456 | Aug. 28, 2024 | TREATMENT OF PULMONARY EMBOLISM (PE) |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | PROPHYLAXIS OF DEEP VEIN THROMBOSIS (DVT) |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | PROPHYLAXIS OF THROMBOEMBOLIC DISEASES IN PEDIATRIC PATIENTS AGED 2 YEARS AND OLDER WITH CONGENITAL HEART DISEASE WHO HAVE UNDERGONE THE FONTAN PROCEDURE AND A BODY WEIGHT OF >=50 KG |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | PROPHYLAXIS OF VENOUS THROMBOEMBOLISM IN ACUTELY ILL MEDICAL PATIENTS AT RISK FOR THROMBOEMBOLIC COMPLICATIONS NOT AT HIGH RISK OF BLEEDING |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | REDUCTION IN THE RISK OF RECURRENCE OF DEEP VEIN THROMBOSIS (DVT) AND/OR PULMONARY EMBOLISM (PE) IN PATIENTS AT CONTINUED RISK FOR RECURRENT DVT AND/OR AFTER COMPLETION OF INITIAL TREATMENT LASTING AT LEAST 6 MONTHS |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | REDUCING THE RISK OF STROKE AND SYSTEMIC EMBOLISM |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | TREATMENT OF DEEP VEIN THROMBOSIS (DVT) |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | TREATMENT OF PULMONARY EMBOLISM (PE) |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | TREATMENT OF VENOUS THROMBOEMBOLISM (VTE) AND THE REDUCTION IN THE RISK OF RECURRENT VTE IN PEDIATRIC PATIENTS FROM BIRTH TO LESS THAN 18 YEARS WITH A BODY WEIGHT OF 30 KG TO 49.9 KG AFTER AT LEAST 5 DAYS OF INITIAL PARENTERAL ANTICOAGULANT TREATMENT |
2.5MG | XARELTO | JANSSEN PHARMS | N022406 | Oct. 11, 2018 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | REDUCTION OF RISK OF MAJOR CARDIOVASCULAR EVENTS (CARDIOVASCULAR DEATH, MYOCARDIAL INFARCTION AND STROKE) IN PATIENTS WITH CAD |
2.5MG | XARELTO | JANSSEN PHARMS | N022406 | Oct. 11, 2018 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | REDUCTION OF RISK OF MAJOR CARDIOVASCULAR EVENTS (CV DEATH, MI, AND STROKE) IN CHRONIC CAD OR PAD |
2.5MG | XARELTO | JANSSEN PHARMS | N022406 | Oct. 11, 2018 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | REDUCTION OF RISK OF MAJOR THROMBOTIC VASCULAR EVENTS (MYOCARDIAL INFARCTION, ISCHEMIC STROKE, ACUTE LIMB ISCHEMIA, AND MAJOR AMPUTATION OF VASCULAR ETIOLOGY) IN PATIENTS WITH PAD |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | REDUCING THE RISK OF STROKE AND SYSTEMIC EMBOLISM |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | TREATMENT OF DEEP VEIN THROMBOSIS (DVT) |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | TREATMENT OF PULMONARY EMBOLISM (PE) |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9415053 | Nov. 13, 2024 | TREATMENT OF VENOUS THROMBOEMBOLISM (VTE) AND THE REDUCTION IN THE RISK OF RECURRENT VTE IN PEDIATRIC PATIENTS FROM BIRTH TO LESS THAN 18 YEARS WITH A BODY WEIGHT OF >=50 KG AFTER AT LEAST 5 DAYS OF INITIAL PARENTERAL ANTICOAGULANT TREATMENT |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | AFTER COMPLETION OF INITIAL TREATMENT LASTING AT LEAST 6 MONTHS, TO REDUCE THE RISK OF RECURRENCE OF DEEP VEIN THROMBOSIS AND/OR PULMONARY EMBOLISM IN CERTAIN PATIENTS WITH ONCE DAILY, RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST 5 CONSECUTIVE DAYS |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | PROPHYLAXIS OF DEEP VEIN THROMBOSIS, WHICH MAY LEAD TO PULMONARY EMBOLISM IN PATIENTS UNDERGOING KNEE OR HIP REPLACEMENT SURGERY, WITH ONCE DAILY, RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST FIVE CONSECUTIVE DAYS |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | PROPHYLAXIS OF PE, DVT AND/OR STROKE IN PEDIATRIC PATIENTS (>=50 KG) AGED 2 YEARS AND OLDER WITH CONGENITAL HEART DISEASE AFTER FONTAN PROCEDURE WITH ONCE DAILY, RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST 5 CONSECUTIVE DAYS |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | PROPHYLAXIS OF VENOUS THROMBOEMBOLISM IN ACUTELY ILL MEDICAL PATIENTS AT RISK FOR THROMBOEMBOLIC COMPLICATIONS NOT AT HIGH RISK OF BLEEDING WITH ONCE DAILY, RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST 5 CONSECUTIVE DAYS |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | REDUCE THE RISK OF STROKE IN PATIENTS WITH NONVALVULAR ATRIAL FIBRILLATION WITH ONCE DAILY, RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST FIVE CONSECUTIVE DAYS |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | TREATMENT OF DVT AND/OR PE AND REDUCTION IN RISK OF RECURRENT DVT AND/OR PE IN PEDIATRIC PATIENTS (30-49.9 KG) ONCE DAILY WITH RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST 5 CONSECUTIVE DAYS AFTER AT LEAST 5 DAYS PARENTERAL ANTICOAGULANT TREATMENT |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | REDUCE THE RISK OF STROKE IN PATIENTS WITH NONVALVULAR ATRIAL FIBRILLATION WITH ONCE DAILY, RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST FIVE CONSECUTIVE DAYS |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | TREATMENT OF DEEP VEIN THROMBOSIS WITH ONCE DAILY, RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST FIVE CONSECUTIVE DAYS |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | TREATMENT OF DVT AND/OR PE AND REDUCTION IN THE RISK OF RECURRENT DVT AND/OR PE IN PEDIATRIC PATIENTS (>=50 KG) ONCE DAILY WITH RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST 5 CONSECUTIVE DAYS AFTER AT LEAST 5 DAYS PARENTERAL ANTICOAGULANT TREATMENT |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | 9539218 | Feb. 17, 2034 | TREATMENT OF PULMONARY EMBOLISM WITH ONCE DAILY, RAPID-RELEASE TABLET ADMINISTERED FOR AT LEAST FIVE CONSECUTIVE DAYS |
2.5MG | XARELTO | JANSSEN PHARMS | N022406 | Oct. 11, 2018 | RX | TABLET | ORAL | 10828310 | Jan. 31, 2039 | REDUCTION OF RISK OF CARDIOVASCULAR DEATH, MYOCARDIAL INFARCTION, AND STROKE IN PATIENTS WITH CAD BY ADMINISTERING CLINICALLY PROVEN EFFECTIVE AMOUNTS THAT ARE 2.5 MG RIVAROXABAN TWICE DAILY AND 75-100 MG ASPIRIN DAILY |
2.5MG | XARELTO | JANSSEN PHARMS | N022406 | Oct. 11, 2018 | RX | TABLET | ORAL | 10828310 | Jan. 31, 2039 | REDUCTION OF RISK OF MYOCARDIAL INFARCTION AND ISCHEMIC STROKE IN PATIENTS WITH PAD BY ADMINISTERING CLINICALLY PROVEN EFFECTIVE AMOUNTS THAT ARE 2.5 MG RIVAROXABAN TWICE DAILY AND 75-100 MG ASPIRIN DAILY |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | Oct. 11, 2022 | PROPHYLAXIS OF VENOUS THROMBOEMBOLISM IN ACUTELY ILL MEDICAL PATIENTS AT RISK FOR THROMBOEMBOLIC COMPLICATIONS NOT AT HIGH RISK OF BLEEDING |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | Oct. 11, 2022 | PROPHYLAXIS OF VENOUS THROMBOEMBOLISM IN ACUTELY ILL MEDICAL PATIENTS AT RISK FOR THROMBOEMBOLIC COMPLICATIONS NOT AT HIGH RISK OF BLEEDING |
2.5MG | XARELTO | JANSSEN PHARMS | N022406 | Oct. 11, 2018 | RX | TABLET | ORAL | Oct. 11, 2022 | PROPHYLAXIS OF VENOUS THROMBOEMBOLISM IN ACUTELY ILL MEDICAL PATIENTS AT RISK FOR THROMBOEMBOLIC COMPLICATIONS NOT AT HIGH RISK OF BLEEDING |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | Oct. 11, 2022 | PROPHYLAXIS OF VENOUS THROMBOEMBOLISM IN ACUTELY ILL MEDICAL PATIENTS AT RISK FOR THROMBOEMBOLIC COMPLICATIONS NOT AT HIGH RISK OF BLEEDING |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | April 11, 2023 | PEDIATRIC EXCLUSIVITY |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | April 11, 2023 | PEDIATRIC EXCLUSIVITY |
2.5MG | XARELTO | JANSSEN PHARMS | N022406 | Oct. 11, 2018 | RX | TABLET | ORAL | April 11, 2023 | PEDIATRIC EXCLUSIVITY |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | April 11, 2023 | PEDIATRIC EXCLUSIVITY |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | Aug. 23, 2024 | INDICATED TO REDUCE THE RISK OF MAJOR THROMBOTIC VASCULAR EVENTS (MYOCARDIAL INFARCTION, ISCHEMIC STROKE, ACUTE LIMB ISCHEMIA, AND MAJOR AMPUTATION OF VASCULAR ETIOLOGY) IN PATIENTS WITH PAD, INCLUDING PATIENTS WHO HAVE RECENTLY UNDERGONE A LOWER EXTREMITY REVASCULARIZATION PROCEDURE DUE TO SYMPTOMATIC PAD |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | Aug. 23, 2024 | INDICATED TO REDUCE THE RISK OF MAJOR THROMBOTIC VASCULAR EVENTS (MYOCARDIAL INFARCTION, ISCHEMIC STROKE, ACUTE LIMB ISCHEMIA, AND MAJOR AMPUTATION OF VASCULAR ETIOLOGY) IN PATIENTS WITH PAD, INCLUDING PATIENTS WHO HAVE RECENTLY UNDERGONE A LOWER EXTREMITY REVASCULARIZATION PROCEDURE DUE TO SYMPTOMATIC PAD |
2.5MG | XARELTO | JANSSEN PHARMS | N022406 | Oct. 11, 2018 | RX | TABLET | ORAL | Aug. 23, 2024 | INDICATED TO REDUCE THE RISK OF MAJOR THROMBOTIC VASCULAR EVENTS (MYOCARDIAL INFARCTION, ISCHEMIC STROKE, ACUTE LIMB ISCHEMIA, AND MAJOR AMPUTATION OF VASCULAR ETIOLOGY) IN PATIENTS WITH PAD, INCLUDING PATIENTS WHO HAVE RECENTLY UNDERGONE A LOWER EXTREMITY REVASCULARIZATION PROCEDURE DUE TO SYMPTOMATIC PAD |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | Aug. 23, 2024 | INDICATED TO REDUCE THE RISK OF MAJOR THROMBOTIC VASCULAR EVENTS (MYOCARDIAL INFARCTION, ISCHEMIC STROKE, ACUTE LIMB ISCHEMIA, AND MAJOR AMPUTATION OF VASCULAR ETIOLOGY) IN PATIENTS WITH PAD, INCLUDING PATIENTS WHO HAVE RECENTLY UNDERGONE A LOWER EXTREMITY REVASCULARIZATION PROCEDURE DUE TO SYMPTOMATIC PAD |
1MG/ML | XARELTO | JANSSEN PHARMS | N215859 | Dec. 20, 2021 | RX | FOR SUSPENSION | ORAL | Dec. 20, 2024 | NEW PRODUCT |
10MG | XARELTO | JANSSEN PHARMS | N022406 | July 1, 2011 | RX | TABLET | ORAL | Feb. 23, 2025 | PEDIATRIC EXCLUSIVITY |
15MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | Feb. 23, 2025 | PEDIATRIC EXCLUSIVITY |
2.5MG | XARELTO | JANSSEN PHARMS | N022406 | Oct. 11, 2018 | RX | TABLET | ORAL | Feb. 23, 2025 | PEDIATRIC EXCLUSIVITY |
20MG | XARELTO | JANSSEN PHARMS | N022406 | Nov. 4, 2011 | RX | TABLET | ORAL | Feb. 23, 2025 | PEDIATRIC EXCLUSIVITY |
1MG/ML | XARELTO | JANSSEN PHARMS | N215859 | Dec. 20, 2021 | RX | FOR SUSPENSION | ORAL | June 20, 2025 | PEDIATRIC EXCLUSIVITY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Coagulation factor X | Enzyme | INHIBITOR | Ki | 9.40 | CHEMBL | CHEMBL | |||
Suppressor of tumorigenicity 14 protein | Enzyme | Ki | 5.47 | CHEMBL | |||||
Coagulation factor X | Enzyme | IC50 | 6.29 | CHEMBL |
ID | Source |
---|---|
D07086 | KEGG_DRUG |
4030906 | VANDF |
CHEBI:68579 | CHEBI |
RIV | PDB_CHEM_ID |
CHEMBL198362 | ChEMBL_ID |
6388 | IUPHAR_LIGAND_ID |
8428 | INN_ID |
DB06228 | DRUGBANK_ID |
9NDF7JZ4M3 | UNII |
9875401 | PUBCHEM_CID |
1114195 | RXNORM |
159029 | MMSL |
26019 | MMSL |
d07356 | MMSL |
012873 | NDDF |
442031002 | SNOMEDCT_US |
442539005 | SNOMEDCT_US |
D000069552 | MESH_DESCRIPTOR_UI |
C1739768 | UMLSCUI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3625 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3639 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 31 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4468 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4469 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50458-575 | GRANULE, FOR SUSPENSION | 155 mg | ORAL | NDA | 35 sections |
XARELTO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50458-577 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 35 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50458-578 | TABLET, FILM COATED | 15 mg | ORAL | NDA | 35 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50458-579 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 35 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50458-580 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 35 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55154-1422 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55154-1423 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Xarelto | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55154-1424 | TABLET, FILM COATED | 15 mg | ORAL | NDA | 32 sections |