bisoprolol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 380 66722-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bisoprolol hemifumarate
  • bisoprolol
  • bisoprolol fumarate
A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.
  • Molecular weight: 325.45
  • Formula: C18H31NO4
  • CLOGP: 1.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 59.95
  • ALOGS: -3.66
  • ROTB: 12

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 63 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.88 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.66 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 88 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
July 31, 1992 FDA TEVA WOMENS
June 28, 2013 PMDA TOA EIYO LTD.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 1783.64 10.42 2957 184416 260458 63041191
Bradycardia 1293.48 10.42 1323 186050 71904 63229745
Drug interaction 878.23 10.42 2026 185347 227105 63074544
Cardiac failure 824.85 10.42 1159 186214 87983 63213666
Hyponatraemia 754.37 10.42 1256 186117 110644 63191005
Hyperkalaemia 742.71 10.42 857 186516 53346 63248303
Atrial fibrillation 628.50 10.42 1187 186186 115449 63186200
Drug ineffective 585.67 10.42 1400 185973 1043365 62258284
General physical health deterioration 577.48 10.42 1596 185777 199806 63101843
Hypotension 498.77 10.42 1851 185522 270753 63030896
Pemphigus 470.60 10.42 16 187357 183710 63117939
Lactic acidosis 446.66 10.42 558 186815 37729 63263920
Glossodynia 443.14 10.42 20 187353 178856 63122793
Pain 427.63 10.42 975 186398 739653 62561996
Systemic lupus erythematosus 419.95 10.42 59 187314 208859 63092790
Syncope 415.11 10.42 1007 186366 116378 63185271
Hand deformity 404.47 10.42 15 187358 159442 63142207
Melaena 387.33 10.42 463 186910 29902 63271747
Anaemia 386.81 10.42 1802 185571 291628 63010021
Swelling 356.45 10.42 184 187189 275194 63026455
Sinusitis 348.74 10.42 117 187256 226536 63075113
Arthropathy 344.57 10.42 131 187242 234661 63066988
Abdominal discomfort 324.58 10.42 282 187091 320603 62981046
Maternal exposure during pregnancy 322.54 10.42 123 187250 219939 63081710
International normalised ratio increased 312.30 10.42 521 186852 45904 63255745
Joint swelling 305.51 10.42 310 187063 327356 62974293
Completed suicide 302.58 10.42 37 187336 145636 63156013
Therapeutic product effect decreased 301.94 10.42 97 187276 193090 63108559
Treatment failure 297.13 10.42 108 187265 198935 63102714
Ischaemic stroke 294.29 10.42 312 187061 17645 63284004
Infusion related reaction 290.55 10.42 183 187190 245338 63056311
Alopecia 286.47 10.42 345 187028 337191 62964458
Product dose omission issue 283.72 10.42 170 187203 234143 63067506
Renal impairment 275.66 10.42 723 186650 87632 63214017
Synovitis 272.99 10.42 105 187268 186813 63114836
Hypokalaemia 255.91 10.42 780 186593 103024 63198625
Haematoma 254.82 10.42 406 186967 34414 63267235
Product prescribing error 252.07 10.42 348 187025 25941 63275708
Rhabdomyolysis 249.79 10.42 458 186915 43493 63258156
Drug intolerance 244.74 10.42 332 187041 308329 62993320
Hypertensive crisis 244.14 10.42 262 187111 15024 63286625
Product use issue 242.65 10.42 178 187195 220342 63081307
Helicobacter infection 241.36 10.42 7 187366 92778 63208871
Sinus bradycardia 236.98 10.42 252 187121 14299 63287350
Cerebral haemorrhage 234.14 10.42 365 187008 30364 63271285
Atrioventricular block complete 224.77 10.42 190 187183 8061 63293588
Arrhythmia 219.97 10.42 400 186973 37740 63263909
Contraindicated product administered 216.61 10.42 194 187179 217454 63084195
Sopor 214.90 10.42 295 187078 21869 63279780
Drug hypersensitivity 214.68 10.42 367 187006 310320 62991329
Discomfort 213.20 10.42 114 187259 167260 63134389
Atrioventricular block 212.25 10.42 178 187195 7469 63294180
Rheumatoid arthritis 207.27 10.42 267 187106 253552 63048097
Systemic infection 205.65 10.42 143 187230 4517 63297132
Exposure during pregnancy 205.48 10.42 101 187272 155446 63146203
Hypoglycaemia 205.45 10.42 509 186864 59556 63242093
Duodenal ulcer perforation 202.77 10.42 14 187359 87195 63214454
Wound 196.77 10.42 119 187254 163144 63138505
Fall 190.48 10.42 1880 185493 390454 62911195
Renal failure 190.15 10.42 769 186604 116883 63184766
Cardiac failure chronic 184.33 10.42 131 187242 4287 63297362
Electrocardiogram QT prolonged 183.43 10.42 485 186888 59045 63242604
Cardiogenic shock 181.94 10.42 244 187129 17688 63283961
Rash 180.80 10.42 947 186426 559924 62741725
Arthralgia 179.72 10.42 969 186404 568741 62732908
Hypomagnesaemia 178.05 10.42 311 187062 28426 63273223
Nasopharyngitis 173.14 10.42 303 187070 253954 63047695
Irritable bowel syndrome 170.91 10.42 21 187352 82391 63219258
Hypersensitivity 170.74 10.42 382 186991 292303 63009346
Shock haemorrhagic 167.60 10.42 175 187198 9720 63291929
Pericarditis 164.07 10.42 92 187281 131487 63170162
Subarachnoid haemorrhage 163.06 10.42 206 187167 14077 63287572
Injection site pain 162.95 10.42 90 187283 129710 63171939
Dyspnoea 160.57 10.42 2790 184583 658523 62643126
Confusional state 160.25 10.42 1220 186153 235160 63066489
Circulatory collapse 159.40 10.42 255 187118 21683 63279966
Left ventricular dysfunction 156.47 10.42 185 187188 11803 63289846
International normalised ratio fluctuation 153.37 10.42 94 187279 2384 63299265
Folliculitis 150.62 10.42 16 187357 70301 63231348
Haematemesis 149.48 10.42 298 187075 30114 63271535
Dehydration 148.84 10.42 948 186425 172406 63129243
Anuria 148.03 10.42 184 187189 12367 63289282
Mitral valve incompetence 146.83 10.42 231 187142 19363 63282286
Upper gastrointestinal haemorrhage 146.50 10.42 226 187147 18626 63283023
Rheumatoid factor positive 145.54 10.42 35 187338 84371 63217278
Bradyarrhythmia 143.22 10.42 85 187288 2030 63299619
Presyncope 139.86 10.42 275 187098 27510 63274139
Orthostatic hypotension 136.05 10.42 318 187055 35842 63265807
Injection site erythema 134.84 10.42 39 187334 83135 63218514
Psoriatic arthropathy 134.21 10.42 51 187322 91469 63210180
Tachyarrhythmia 132.71 10.42 108 187265 4342 63297307
Rectal haemorrhage 131.74 10.42 380 186993 48650 63252999
Haematochezia 131.54 10.42 402 186971 53142 63248507
Subdural haematoma 124.52 10.42 181 187192 14147 63287502
Fatigue 120.10 10.42 1873 185500 886155 62415494
Gastrointestinal haemorrhage 118.15 10.42 514 186859 80662 63220987
Angina pectoris 118.09 10.42 269 187104 29809 63271840
Infection 117.21 10.42 320 187053 228853 63072796
Fibromyalgia 115.96 10.42 46 187327 80374 63221275
Ejection fraction decreased 113.58 10.42 222 187151 22110 63279539
Death 113.29 10.42 645 186728 373736 62927913
Vertigo 111.89 10.42 410 186963 59477 63242172
Oedema peripheral 110.35 10.42 945 186428 188566 63113083
Cholestasis 109.80 10.42 258 187115 29176 63272473
Torsade de pointes 109.32 10.42 164 187209 13187 63288462
Off label use 107.87 10.42 1375 185998 673087 62628562
Product monitoring error 106.90 10.42 96 187277 4420 63297229
Hemiplegia 105.68 10.42 134 187239 9189 63292460
Cerebral infarction 105.48 10.42 224 187149 23669 63277980
Acute coronary syndrome 101.52 10.42 137 187236 9989 63291660
Blister 99.34 10.42 143 187230 129671 63171978
Hip arthroplasty 99.13 10.42 12 187361 47634 63254015
Labelled drug-drug interaction medication error 99.06 10.42 157 187216 13242 63288407
Vital capacity decreased 97.98 10.42 62 187311 1666 63299983
Ill-defined disorder 96.49 10.42 61 187312 81694 63219955
Hepatic enzyme increased 95.77 10.42 293 187080 202035 63099614
Injection site pruritus 94.76 10.42 11 187362 45105 63256544
Bloody discharge 93.87 10.42 58 187315 1493 63300156
Stomatitis 93.72 10.42 166 187207 138559 63163090
Headache 92.48 10.42 1315 186058 631926 62669723
Knee arthroplasty 92.42 10.42 23 187350 54183 63247466
Hypocalcaemia 92.25 10.42 253 187120 31460 63270189
Atrial flutter 91.62 10.42 128 187245 9644 63292005
Acute myocardial infarction 91.19 10.42 254 187119 31870 63269779
Metabolic acidosis 90.54 10.42 316 187057 44753 63256896
Atrial tachycardia 90.38 10.42 85 187288 4155 63297494
Impaired healing 89.81 10.42 102 187271 102440 63199209
Hemiparesis 88.94 10.42 206 187167 23076 63278573
Hallucination, visual 87.60 10.42 183 187190 19115 63282534
Electrolyte imbalance 87.22 10.42 187 187186 19889 63281760
Reversible airways obstruction 87.13 10.42 59 187314 1783 63299866
Erysipelas 87.05 10.42 112 187261 7793 63293856
Tachycardia 85.13 10.42 619 186754 117537 63184112
Weight increased 85.04 10.42 438 186935 260354 63041295
Glomerular filtration rate decreased 83.95 10.42 146 187227 13295 63288354
Musculoskeletal stiffness 82.71 10.42 274 187099 184344 63117305
Pregnancy 82.54 10.42 7 187366 36829 63264820
Injection site reaction 81.90 10.42 35 187338 58489 63243160
Cardioactive drug level increased 79.92 10.42 60 187313 2140 63299509
Vasoplegia syndrome 79.36 10.42 54 187319 1645 63300004
Upper respiratory tract infection 79.31 10.42 75 187298 81972 63219677
Palpitations 79.07 10.42 587 186786 112183 63189466
Eosinophilia 79.00 10.42 194 187179 22562 63279087
Skin haemorrhage 78.41 10.42 121 187252 9973 63291676
Jaundice 77.88 10.42 226 187147 29025 63272624
Hospitalisation 77.41 10.42 82 187291 84999 63216650
Sputum culture positive 76.29 10.42 58 187315 2109 63299540
Cardiospasm 76.01 10.42 55 187318 1852 63299797
Adverse drug reaction 75.74 10.42 74 187299 79640 63222009
Blood cholesterol increased 75.53 10.42 100 187273 93932 63207717
Abortion spontaneous 74.90 10.42 23 187350 47172 63254477
Asthenia 74.36 10.42 1565 185808 382039 62919610
Hepatocellular injury 74.30 10.42 213 187160 27168 63274481
Sinus node dysfunction 74.27 10.42 80 187293 4605 63297044
Epistaxis 74.03 10.42 416 186957 72309 63229340
Ventricular tachycardia 73.29 10.42 174 187199 19805 63281844
Neuropathy peripheral 73.22 10.42 140 187233 113527 63188122
Polyneuropathy 72.94 10.42 144 187229 14445 63287204
Disease progression 71.64 10.42 160 187213 122598 63179051
Palmoplantar keratoderma 71.28 10.42 54 187319 1953 63299696
Pruritus genital 70.00 10.42 60 187313 2594 63299055
Pain in extremity 68.74 10.42 636 186737 330850 62970799
Gastrointestinal disorder 68.74 10.42 181 187192 131058 63170591
C-reactive protein abnormal 68.72 10.42 25 187348 46071 63255578
Adverse event 68.59 10.42 59 187314 67500 63234149
Injury 68.43 10.42 69 187304 73178 63228471
Ventricular fibrillation 66.56 10.42 123 187250 11744 63289905
Asthma 66.00 10.42 177 187196 127384 63174265
Hyponatraemic syndrome 64.75 10.42 32 187341 523 63301126
Microcytic anaemia 64.17 10.42 64 187309 3365 63298284
Bronchial secretion retention 63.77 10.42 58 187315 2715 63298934
N-terminal prohormone brain natriuretic peptide increased 63.50 10.42 52 187321 2109 63299540
Hypoaesthesia 62.99 10.42 269 187104 168124 63133525
Malignant mediastinal neoplasm 62.93 10.42 44 187329 1402 63300247
Cardiac failure acute 62.84 10.42 106 187267 9417 63292232
Injection site swelling 62.60 10.42 31 187342 47541 63254108
Unevaluable event 62.49 10.42 37 187336 51349 63250300
Depression 61.79 10.42 334 187039 196158 63105491
Hallucination 61.49 10.42 322 187051 54495 63247154
Dyspnoea exertional 61.41 10.42 345 187028 59957 63241692
Wrong patient received product 60.48 10.42 51 187322 2156 63299493
Peripheral swelling 59.18 10.42 501 186872 265441 63036208
Neurologic neglect syndrome 58.86 10.42 55 187318 2666 63298983
Mental status changes 58.15 10.42 22 187351 39577 63262072
Blood creatinine increased 58.06 10.42 451 186922 87393 63214256
Sleep terror 57.65 10.42 54 187319 2626 63299023
Disorientation 57.52 10.42 250 187123 39202 63262447
Illness 57.34 10.42 37 187336 49022 63252627
Bursitis 57.09 10.42 19 187354 37022 63264627
Cerebral ischaemia 57.02 10.42 84 187289 6644 63295005
Therapy interrupted 56.84 10.42 13 187360 32442 63269207
Dizziness 56.68 10.42 1665 185708 428260 62873389
Lyme disease 56.63 10.42 60 187313 3389 63298260
White blood cell count decreased 56.57 10.42 215 187158 138889 63162760
Contusion 55.92 10.42 240 187133 149804 63151845
Hypovolaemic shock 55.92 10.42 80 187293 6161 63295488
Carotid artery thrombosis 55.73 10.42 54 187319 2740 63298909
Gamma-glutamyltransferase increased 55.35 10.42 223 187150 33808 63267841
Renin increased 55.22 10.42 21 187352 173 63301476
Loss of consciousness 55.12 10.42 562 186811 117559 63184090
Joint range of motion decreased 54.81 10.42 14 187359 32414 63269235
Pleural effusion 54.29 10.42 465 186908 92745 63208904
Carotid artery occlusion 54.05 10.42 68 187305 4626 63297023
Congestive cardiomyopathy 53.58 10.42 78 187295 6104 63295545
Pallor 53.52 10.42 205 187168 30363 63271286
Toxic epidermal necrolysis 52.94 10.42 180 187193 25154 63276495
Night sweats 52.84 10.42 40 187333 48774 63252875
Hypothermia 52.79 10.42 121 187252 13460 63288189
Aphasia 52.69 10.42 215 187158 32785 63268864
Injection site bruising 52.65 10.42 29 187344 41881 63259768
Prerenal failure 52.35 10.42 42 187331 1654 63299995
Atrial thrombosis 51.86 10.42 43 187330 1775 63299874
Lower respiratory tract infection 51.56 10.42 208 187165 132099 63169550
Mobility decreased 51.40 10.42 184 187189 120975 63180674
Electrocardiogram abnormal 51.30 10.42 95 187278 9084 63292565
Immunisation 51.22 10.42 36 187337 1157 63300492
Urticaria 50.93 10.42 284 187089 165518 63136131
Tinnitus 50.59 10.42 224 187149 35404 63266245
Coma scale abnormal 50.56 10.42 69 187304 5084 63296565
Haemarthrosis 50.15 10.42 54 187319 3107 63298542
Migraine 50.05 10.42 148 187225 103198 63198451
Therapy cessation 49.87 10.42 14 187359 30443 63271206
Acute cutaneous lupus erythematosus 49.57 10.42 22 187351 278 63301371
Transaminases increased 49.00 10.42 203 187170 31164 63270485
Haematuria 48.98 10.42 193 187180 28964 63272685
Embolic stroke 48.82 10.42 58 187315 3718 63297931
Product quality issue 47.76 10.42 23 187350 35842 63265807
Polyuria 47.23 10.42 88 187285 8454 63293195
Myopathy 47.19 10.42 103 187270 11088 63290561
Bundle branch block left 47.14 10.42 79 187294 6980 63294669
Lupus vasculitis 46.91 10.42 26 187347 543 63301106
Blood creatine phosphokinase increased 46.81 10.42 196 187177 30234 63271415
Full blood count decreased 46.43 10.42 10 187363 26014 63275635
Insomnia 46.31 10.42 409 186964 214843 63086806
Therapy non-responder 45.86 10.42 97 187276 75804 63225845
Iron deficiency anaemia 45.40 10.42 146 187227 19823 63281826
Pancytopenia 45.12 10.42 461 186912 96472 63205177
Paresis 45.11 10.42 46 187327 2484 63299165
Urinary retention 44.93 10.42 193 187180 30108 63271541
Multiple sclerosis relapse 44.90 10.42 46 187327 48432 63253217
Cerebrovascular accident 44.81 10.42 502 186871 107522 63194127
Lip swelling 44.64 10.42 196 187177 30867 63270782
Ear infection 44.41 10.42 29 187344 38184 63263465
Agranulocytosis 44.36 10.42 169 187204 24965 63276684
Blood pressure decreased 44.16 10.42 336 187037 64686 63236963
Tachypnoea 43.50 10.42 131 187242 17171 63284478
Thrombocytopenia 43.18 10.42 656 186717 150501 63151148
Myocardial infarction 43.17 10.42 468 186905 99425 63202224
Sleep disorder 43.07 10.42 112 187261 81454 63220195
Haemorrhage intracranial 43.02 10.42 111 187262 13308 63288341
Spontaneous haemorrhage 43.00 10.42 25 187348 574 63301075
Toxic skin eruption 42.77 10.42 108 187265 12777 63288872
Colitis erosive 42.56 10.42 15 187358 97 63301552
Bronchitis 42.28 10.42 207 187166 124728 63176921
Flushing 42.07 10.42 100 187273 74987 63226662
Lower limb fracture 41.82 10.42 10 187363 24211 63277438
Faecaloma 41.67 10.42 80 187293 7861 63293788
Haemorrhagic stroke 41.62 10.42 67 187306 5725 63295924
Left ventricular failure 41.16 10.42 66 187307 5621 63296028
Road traffic accident 40.97 10.42 29 187344 36603 63265046
Osteoarthritis 40.97 10.42 144 187229 95199 63206450
Orthopnoea 40.39 10.42 69 187304 6192 63295457
Restlessness 40.18 10.42 183 187190 29270 63272379
Acute pulmonary oedema 40.15 10.42 80 187293 8078 63293571
Type 2 diabetes mellitus 39.96 10.42 80 187293 63788 63237861
No adverse event 39.83 10.42 38 187335 41367 63260282
Blood pressure increased 39.82 10.42 686 186687 161376 63140273
Live birth 39.76 10.42 13 187360 25617 63276032
Adjustment disorder 39.75 10.42 48 187325 3130 63298519
Heart rate decreased 39.54 10.42 250 187123 45310 63256339
Blood pressure systolic decreased 39.40 10.42 75 187298 7322 63294327
Atrioventricular block first degree 39.06 10.42 74 187299 7199 63294450
Tricuspid valve incompetence 38.95 10.42 113 187260 14508 63287141
Grip strength decreased 38.88 10.42 9 187364 22278 63279371
Device issue 38.81 10.42 11 187362 23770 63277879
Bradyphrenia 38.71 10.42 72 187301 6908 63294741
Joint stiffness 38.47 10.42 40 187333 41829 63259820
Blood immunoglobulin E increased 38.47 10.42 52 187321 3797 63297852
Altered state of consciousness 38.41 10.42 162 187211 25068 63276581
Infusion site pain 38.36 10.42 3 187370 16866 63284783
Conjoined twins 38.29 10.42 18 187355 262 63301387
Basilar artery occlusion 38.18 10.42 14 187359 103 63301546
Inappropriate antidiuretic hormone secretion 37.87 10.42 116 187257 15346 63286303
Angioedema 37.86 10.42 257 187116 47708 63253941
Dermatitis bullous 37.82 10.42 80 187293 8428 63293221
Hyperthyroidism 37.75 10.42 112 187261 14561 63287088
Subcutaneous haematoma 37.69 10.42 35 187338 1683 63299966
Femoral hernia incarcerated 37.56 10.42 26 187347 815 63300834
Personality disorder 37.44 10.42 64 187309 5747 63295902
Hepatitis acute 37.39 10.42 83 187290 9037 63292612
Faeces discoloured 37.36 10.42 130 187243 18379 63283270
Tension headache 37.28 10.42 60 187313 5126 63296523
Cardiovascular disorder 37.14 10.42 97 187276 11715 63289934
Vasculitis 36.84 10.42 128 187245 18081 63283568
Vomiting 36.70 10.42 2010 185363 557607 62744042
Urine output decreased 36.39 10.42 94 187279 11276 63290373
N-terminal prohormone brain natriuretic peptide abnormal 36.15 10.42 11 187362 41 63301608
Anosmia 35.86 10.42 69 187304 6791 63294858
Osteoporosis 35.72 10.42 72 187301 57266 63244383
Petechiae 35.68 10.42 106 187267 13791 63287858
Coronary artery stenosis 35.64 10.42 56 187317 4688 63296961
Aortic arteriosclerosis 35.63 10.42 65 187308 6144 63295505
Orthostatic intolerance 35.59 10.42 29 187344 1168 63300481
Nocturia 35.55 10.42 76 187297 8065 63293584
Sight disability 35.45 10.42 14 187359 129 63301520
Cardiac tamponade 35.36 10.42 56 187317 4719 63296930
Optic ischaemic neuropathy 35.06 10.42 29 187344 1193 63300456
Abnormal loss of weight 35.06 10.42 62 187311 5720 63295929
Disability 34.95 10.42 6 187367 18341 63283308
Potentiating drug interaction 34.94 10.42 53 187320 4303 63297346
Bundle branch block right 34.81 10.42 57 187316 4941 63296708
Abdominal wall haematoma 34.77 10.42 44 187329 3011 63298638
Transient ischaemic attack 34.55 10.42 210 187163 37543 63264106
Therapeutic drug monitoring analysis not performed 34.51 10.42 30 187343 1322 63300327
Epileptic encephalopathy 34.28 10.42 17 187356 280 63301369
Irritability 34.26 10.42 26 187347 31668 63269981
Gastrooesophageal reflux disease 33.80 10.42 156 187217 95483 63206166
Aortic valve stenosis 33.63 10.42 45 187328 3254 63298395
Multiple organ dysfunction syndrome 33.49 10.42 284 187089 56468 63245181
Gravitational oedema 33.15 10.42 28 187345 1186 63300463
Oliguria 33.09 10.42 79 187294 9022 63292627
Product use in unapproved indication 32.72 10.42 354 187019 178726 63122923
Medication error 32.65 10.42 265 187108 52019 63249630
Stress 32.65 10.42 96 187277 67071 63234578
Lower gastrointestinal haemorrhage 32.57 10.42 72 187301 7818 63293831
Interstitial lung disease 32.51 10.42 302 187071 61606 63240043
Psychomotor retardation 32.34 10.42 48 187325 3822 63297827
Sinus arrest 32.17 10.42 34 187339 1915 63299734
Lip dry 31.92 10.42 4 187369 15466 63286183
Gait inability 31.72 10.42 68 187305 52891 63248758
Retroperitoneal haematoma 31.65 10.42 41 187332 2872 63298777
Bone erosion 31.22 10.42 7 187366 17710 63283939
Pancreatic steatosis 31.02 10.42 25 187348 991 63300658
Tachycardia paroxysmal 30.80 10.42 16 187357 292 63301357
Chills 30.71 10.42 202 187171 113176 63188473
Tooth disorder 30.56 10.42 23 187350 28134 63273515
Blood loss anaemia 30.46 10.42 76 187297 8925 63292724
Motor dysfunction 30.45 10.42 85 187288 10676 63290973
Myelosuppression 30.36 10.42 16 187357 23687 63277962
Therapeutic product effect incomplete 30.35 10.42 230 187143 124826 63176823
Sinus rhythm 30.33 10.42 23 187350 833 63300816
Vascular purpura 30.30 10.42 29 187344 1449 63300200
Pemphigoid 30.29 10.42 67 187306 7277 63294372
Arterial haemorrhage 30.22 10.42 31 187342 1686 63299963
Lymphatic fistula 29.81 10.42 22 187351 764 63300885
Dysarthria 29.73 10.42 222 187151 42489 63259160
Device malfunction 29.63 10.42 8 187365 17849 63283800
Thalamus haemorrhage 29.52 10.42 21 187352 688 63300961
Dyspnoea at rest 29.06 10.42 47 187326 4032 63297617
Drug reaction with eosinophilia and systemic symptoms 28.95 10.42 185 187188 33651 63267998
Coma 28.94 10.42 304 187069 64060 63237589
Congenital bladder anomaly 28.83 10.42 13 187360 171 63301478
Fungal infection 28.80 10.42 40 187333 36834 63264815
Hypersensitivity vasculitis 28.78 10.42 47 187326 4065 63297584
Muscular weakness 28.64 10.42 514 186859 121839 63179810
Diabetic metabolic decompensation 28.52 10.42 30 187343 1680 63299969
Cerebral haematoma 28.39 10.42 44 187329 3639 63298010
Thrombosis 28.35 10.42 97 187276 64658 63236991
Urachal abnormality 28.30 10.42 13 187360 179 63301470
Intestinal transit time abnormal 28.20 10.42 10 187363 66 63301583
Respiratory arrest 28.00 10.42 33 187340 32612 63269037
Ventricular extrasystoles 27.99 10.42 87 187286 11600 63290049
Vascular encephalopathy 27.99 10.42 17 187356 424 63301225
Lichen planopilaris 27.97 10.42 9 187364 42 63301607
Eczema 27.90 10.42 177 187196 32114 63269535
Back pain 27.86 10.42 581 186792 263564 63038085
Shock 27.82 10.42 140 187233 23323 63278326
Exostosis 27.81 10.42 9 187364 17853 63283796
Peripheral embolism 27.67 10.42 26 187347 1269 63300380
Anaemia macrocytic 27.66 10.42 42 187331 3412 63298237
Language disorder 27.63 10.42 33 187340 2127 63299522
Memory impairment 27.61 10.42 187 187186 104071 63197578
Androgenetic alopecia 27.51 10.42 12 187361 145 63301504
Platelet count decreased 27.51 10.42 215 187158 115907 63185742
Persistent cloaca 27.48 10.42 13 187360 192 63301457
Laryngitis 27.41 10.42 8 187365 16959 63284690
Ear pain 27.40 10.42 40 187333 36078 63265571
Drug monitoring procedure not performed 27.35 10.42 19 187354 599 63301050
Hepatitis 27.23 10.42 206 187167 39582 63262067
Therapeutic response decreased 27.05 10.42 92 187281 61433 63240216
Erythrodermic psoriasis 26.82 10.42 23 187350 995 63300654
Gallbladder disorder 26.79 10.42 11 187362 18831 63282818
Nephrolithiasis 26.77 10.42 52 187321 41932 63259717
Drug ineffective for unapproved indication 26.56 10.42 37 187336 34026 63267623
Haemorrhagic diathesis 26.33 10.42 47 187326 4368 63297281
Diverticulum intestinal 26.30 10.42 60 187313 6653 63294996
Injection site haemorrhage 26.21 10.42 20 187353 24294 63277355
Wrong technique in product usage process 26.21 10.42 95 187278 62245 63239404
Fracture 26.21 10.42 121 187252 19463 63282186
Sudden hearing loss 26.21 10.42 25 187348 1244 63300405
Skin weeping 26.17 10.42 20 187353 733 63300916
Stress cardiomyopathy 26.11 10.42 74 187299 9376 63292273
Surgery 26.06 10.42 41 187332 35871 63265778
Thermohypoaesthesia 26.06 10.42 11 187362 122 63301527
Drug level increased 25.79 10.42 134 187239 22602 63279047
Neck pain 25.73 10.42 111 187262 69207 63232442
Intestinal haemorrhage 25.62 10.42 43 187330 3804 63297845
Laboratory test abnormal 25.53 10.42 25 187348 26887 63274762
Bone density decreased 25.29 10.42 6 187367 14606 63287043
Feeling abnormal 25.27 10.42 298 187075 148094 63153555
Oropharyngeal pain 25.25 10.42 169 187204 94318 63207331
Spontaneous haematoma 25.22 10.42 21 187352 872 63300777
Macular degeneration 25.09 10.42 21 187352 24355 63277294
Sciatica 25.08 10.42 39 187334 34285 63267364
Overdose 25.04 10.42 478 186895 114600 63187049
Intestinal malrotation 25.02 10.42 15 187358 365 63301284
Eosinophil count increased 24.94 10.42 80 187293 10848 63290801
Gastroenteritis viral 24.91 10.42 20 187353 23680 63277969
Polycythaemia 24.78 10.42 21 187352 894 63300755
Musculoskeletal discomfort 24.73 10.42 11 187362 17956 63283693
Anal haemorrhage 24.68 10.42 31 187342 2105 63299544
Haematoma muscle 24.63 10.42 23 187350 1114 63300535
Pulmonary oedema 24.59 10.42 259 187114 54614 63247035
Hypochloraemia 24.57 10.42 30 187343 1979 63299670
Waist circumference increased 24.52 10.42 21 187352 907 63300742
Arterial occlusive disease 24.18 10.42 54 187319 5904 63295745
Respiratory tract infection 24.16 10.42 207 187166 41276 63260373
Pancreatitis acute 24.15 10.42 150 187223 27016 63274633
Myositis 24.09 10.42 71 187302 9195 63292454
Retinal artery occlusion 24.08 10.42 27 187346 1626 63300023
Loss of personal independence in daily activities 24.05 10.42 178 187195 97112 63204537
Eye disorder 24.03 10.42 19 187354 22666 63278983
Dermatitis exfoliative 23.88 10.42 51 187322 5408 63296241
Purpura 23.88 10.42 81 187292 11304 63290345
Oral herpes 23.85 10.42 25 187348 26049 63275600
Clostridium difficile infection 23.83 10.42 32 187341 29890 63271759
Herpes zoster 23.83 10.42 144 187229 82318 63219331
Thiopurine methyltransferase decreased 23.64 10.42 14 187359 333 63301316
Hepatic cytolysis 23.51 10.42 99 187274 15308 63286341
Deprescribing error 23.45 10.42 7 187366 24 63301625
Multimorbidity 23.38 10.42 17 187356 577 63301072
Product administration error 23.37 10.42 129 187244 22268 63279381
Disease recurrence 23.33 10.42 29 187344 28001 63273648
Sinoatrial block 23.27 10.42 20 187353 868 63300781
Neuropathy, ataxia, retinitis pigmentosa syndrome 23.20 10.42 8 187365 48 63301601
Accidental exposure to product 23.19 10.42 28 187345 27377 63274272
Hepatorenal failure 23.17 10.42 18 187355 676 63300973
Leukopenia 23.05 10.42 338 187035 76952 63224697
Neovascular age-related macular degeneration 23.00 10.42 12 187361 221 63301428
Hypereosinophilic syndrome 22.98 10.42 13 187360 283 63301366
Seasonal allergy 22.89 10.42 17 187356 20933 63280716
Peripheral arterial occlusive disease 22.88 10.42 43 187330 4158 63297491
Delirium 22.86 10.42 239 187134 50302 63251347
Acne 22.85 10.42 21 187352 23272 63278377
Face oedema 22.84 10.42 119 187254 20093 63281556
Emotional distress 22.83 10.42 38 187335 32511 63269138
Femoral neck fracture 22.83 10.42 66 187307 8457 63293192
Serum procollagen type I N-terminal propeptide increased 22.82 10.42 7 187366 27 63301622
Embolic cerebral infarction 22.69 10.42 16 187357 517 63301132
Infective exacerbation of chronic obstructive airways disease 22.68 10.42 23 187350 1234 63300415
Supraventricular extrasystoles 22.58 10.42 45 187328 4544 63297105
Suicidal ideation 22.54 10.42 101 187272 62320 63239329
Complication associated with device 22.43 10.42 11 187362 16967 63284682
Electrocardiogram ST segment elevation 22.39 10.42 41 187332 3886 63297763
Mood swings 22.38 10.42 13 187360 18235 63283414
Back disorder 22.37 10.42 3 187370 11014 63290635
Pyroglutamic acidosis 22.36 10.42 17 187356 618 63301031
Infective spondylitis 22.25 10.42 11 187362 180 63301469
Ventricular hypokinesia 22.21 10.42 45 187328 4599 63297050
Emotional disorder 22.18 10.42 6 187367 13373 63288276
Diverticulum intestinal haemorrhagic 21.89 10.42 25 187348 1536 63300113
Deformity 21.87 10.42 4 187369 11680 63289969
Skin dystrophy 21.80 10.42 8 187365 59 63301590
Rash maculo-papular 21.75 10.42 165 187208 31731 63269918
Diplopia 21.71 10.42 132 187241 23596 63278053
Chronic kidney disease 21.64 10.42 217 187156 45181 63256468
Ketoacidosis 21.63 10.42 43 187330 4335 63297314
Wound infection pseudomonas 21.62 10.42 23 187350 1305 63300344
Sensory loss 21.62 10.42 73 187300 10165 63291484
Multiple sclerosis 21.59 10.42 24 187349 24348 63277301
Metabolic alkalosis 21.44 10.42 35 187338 3026 63298623
Exercise tolerance decreased 21.39 10.42 49 187324 5448 63296201
Iron deficiency 21.34 10.42 58 187315 7172 63294477
Hepatitis toxic 21.18 10.42 36 187337 3217 63298432
Muscle spasms 21.02 10.42 329 187044 155821 63145828
Long QT syndrome 20.97 10.42 36 187337 3243 63298406
Troponin T increased 20.92 10.42 22 187351 1232 63300417
Eastern Cooperative Oncology Group performance status worsened 20.92 10.42 22 187351 1232 63300417
Vitamin B12 decreased 20.90 10.42 38 187335 3582 63298067
Lethargy 20.87 10.42 255 187118 55752 63245897
Bicytopenia 20.83 10.42 31 187342 2474 63299175
Neoplasm malignant 20.82 10.42 35 187338 29826 63271823
Ligament sprain 20.74 10.42 6 187367 12794 63288855
Myocardial ischaemia 20.70 10.42 84 187289 12775 63288874
Foot fracture 20.70 10.42 24 187349 23890 63277759
Peripheral ischaemia 20.69 10.42 45 187328 4833 63296816
Transcription medication error 20.68 10.42 11 187362 211 63301438
Breast cancer stage III 20.68 10.42 3 187370 10383 63291266
Small cell carcinoma 20.65 10.42 10 187363 156 63301493
Arthritis 20.43 10.42 231 187142 115690 63185959
Catarrh 20.37 10.42 24 187349 1525 63300124
Blood calcium decreased 20.35 10.42 29 187344 26422 63275227
Tenderness 20.26 10.42 22 187351 22556 63279093
Aortic valve calcification 20.25 10.42 15 187358 524 63301125
Adjustment disorder with depressed mood 20.20 10.42 3 187370 10201 63291448
Foot deformity 20.02 10.42 32 187341 27821 63273828
Blood uric acid increased 19.96 10.42 47 187326 5320 63296329
Anxiety 19.95 10.42 489 186884 217052 63084597
Hyperuricaemia 19.94 10.42 47 187326 5323 63296326
Rhinitis allergic 19.94 10.42 5 187368 11722 63289927
Hyperglycaemia 19.89 10.42 200 187173 41667 63259982
Hepatocellular carcinoma 19.48 10.42 28 187345 2166 63299483
Ocular icterus 19.39 10.42 37 187336 3619 63298030
Procollagen type I C-terminal propeptide increased 19.39 10.42 6 187367 24 63301625
Seizure 19.38 10.42 275 187098 132359 63169290
Craniocerebral injury 19.32 10.42 32 187341 2800 63298849
Lupus nephritis 19.26 10.42 32 187341 2807 63298842
Chest pain 19.25 10.42 800 186573 215159 63086490
Hypertensive angiopathy 19.25 10.42 8 187365 85 63301564
Sedation 19.20 10.42 55 187318 38754 63262895
Cerebral artery occlusion 19.19 10.42 18 187355 877 63300772
Administration site discomfort 19.17 10.42 8 187365 86 63301563
Intentional product use issue 19.11 10.42 264 187109 127628 63174021
Periorbital haematoma 19.03 10.42 17 187356 777 63300872
Extrasystoles 18.99 10.42 45 187328 5115 63296534
Agitation 18.88 10.42 264 187109 59493 63242156
Urosepsis 18.86 10.42 106 187267 18418 63283231
Malaise 18.83 10.42 1448 185925 414506 62887143
Hypoglycaemic coma 18.79 10.42 30 187343 2545 63299104
Obstructive pancreatitis 18.71 10.42 13 187360 410 63301239
Influenza 18.63 10.42 218 187155 108504 63193145
Enanthema 18.63 10.42 13 187360 413 63301236
Small intestinal obstruction 18.62 10.42 16 187357 18321 63283328
Sputum culture 18.52 10.42 11 187362 263 63301386
Nephrosclerosis 18.49 10.42 19 187354 1035 63300614
Cholestatic liver injury 18.49 10.42 30 187343 2580 63299069
Cannabinoid hyperemesis syndrome 18.48 10.42 7 187366 57 63301592
Paraesthesia 18.43 10.42 339 187034 156627 63145022
Coagulation time prolonged 18.32 10.42 22 187351 1426 63300223
Obesity 18.32 10.42 38 187335 29914 63271735
Nodule 18.31 10.42 21 187352 21005 63280644
Nasal congestion 18.27 10.42 116 187257 65544 63236105
Premature labour 18.27 10.42 7 187366 12497 63289152
Sudden death 18.23 10.42 70 187303 10379 63291270
Anhedonia 18.05 10.42 5 187368 10969 63290680
Muscle haemorrhage 17.89 10.42 33 187340 3146 63298503
Immunodeficiency 17.88 10.42 20 187353 20234 63281415
Acidosis 17.78 10.42 73 187300 11160 63290489
First trimester pregnancy 17.78 10.42 5 187368 13 63301636
Blood pressure systolic increased 17.75 10.42 216 187157 47181 63254468
Bladder sphincter atony 17.74 10.42 9 187364 156 63301493
Drug dependence 17.72 10.42 28 187345 24455 63277194
Haemorrhagic transformation stroke 17.69 10.42 20 187353 1215 63300434
Plasma cell myeloma 17.68 10.42 51 187322 35854 63265795
Eye haematoma 17.68 10.42 7 187366 65 63301584
Troponin I increased 17.62 10.42 27 187346 2211 63299438
Polydipsia 17.60 10.42 35 187338 3529 63298120
Brain stem haemorrhage 17.57 10.42 16 187357 750 63300899
Ventricular internal diameter abnormal 17.54 10.42 6 187367 35 63301614
Ultrasound uterus abnormal 17.49 10.42 7 187366 67 63301582
Acute generalised exanthematous pustulosis 17.47 10.42 72 187301 11027 63290622
Mucosal dryness 17.39 10.42 30 187343 2714 63298935
Liver injury 17.32 10.42 106 187267 60414 63241235
Candida infection 17.32 10.42 36 187337 28315 63273334
Therapy partial responder 17.26 10.42 5 187368 10653 63290996
Psychogenic visual disorder 17.26 10.42 5 187368 15 63301634
Dilatation ventricular 17.18 10.42 28 187345 2417 63299232
Myocarditis 17.06 10.42 68 187305 10257 63291392
Pustule 17.05 10.42 23 187350 1676 63299973
Rash scarlatiniform 17.04 10.42 8 187365 116 63301533
Immune thrombocytopenia 17.03 10.42 69 187304 10487 63291162
Skin discolouration 17.01 10.42 56 187317 37772 63263877
Urinary straining 17.00 10.42 6 187367 39 63301610
Peripheral artery haematoma 17.00 10.42 6 187367 39 63301610
Tetany 16.98 10.42 25 187348 1976 63299673
Sleep apnoea syndrome 16.96 10.42 38 187335 29095 63272554
Walking disability 16.95 10.42 21 187352 1406 63300243
Gonorrhoea 16.92 10.42 8 187365 118 63301531
Faeces pale 16.86 10.42 23 187350 1694 63299955
Inappropriate schedule of product administration 16.85 10.42 211 187162 103754 63197895
Aortic dissection 16.82 10.42 25 187348 1993 63299656
Epilepsy 16.80 10.42 137 187236 26928 63274721
Cardiovascular insufficiency 16.79 10.42 21 187352 1420 63300229
Gastric ulcer 16.76 10.42 125 187248 23912 63277737
Gastrointestinal sounds abnormal 16.76 10.42 37 187336 4014 63297635
Hypertrophic cardiomyopathy 16.72 10.42 22 187351 1565 63300084
Kussmaul respiration 16.66 10.42 10 187363 244 63301405
Subileus 16.65 10.42 32 187341 3147 63298502
Staphylococcal scalded skin syndrome 16.63 10.42 8 187365 123 63301526
Nodal rhythm 16.59 10.42 23 187350 1720 63299929
Neutrophil count decreased 16.56 10.42 98 187275 56308 63245341
Disturbance in attention 16.52 10.42 179 187194 38010 63263639
Prescribed overdose 16.46 10.42 49 187324 34104 63267545
Dysaesthesia 16.42 10.42 39 187334 4439 63297210
Renal artery stenosis 16.42 10.42 24 187349 1885 63299764
Gastric pH increased 16.38 10.42 6 187367 44 63301605
Monoparesis 16.29 10.42 22 187351 1605 63300044
Hepatitis cholestatic 16.29 10.42 51 187322 6827 63294822
Psoriasis 16.23 10.42 171 187202 86786 63214863
Accidental overdose 16.13 10.42 121 187252 23188 63278461
Tuberculosis of central nervous system 16.11 10.42 11 187362 337 63301312
Hyporesponsive to stimuli 16.02 10.42 18 187355 1086 63300563
Eye irritation 16.02 10.42 25 187348 21946 63279703
Cachexia 15.98 10.42 45 187328 5681 63295968
Pericardial effusion 15.96 10.42 147 187226 29911 63271738
Abdominal pain 15.94 10.42 1037 186336 292419 63009230
Eyelid retraction 15.93 10.42 6 187367 48 63301601
Hip fracture 15.92 10.42 40 187333 29434 63272215
Viral infection 15.90 10.42 53 187320 35610 63266039
Ventricular arrhythmia 15.88 10.42 35 187338 3793 63297856
Coeliac disease 15.86 10.42 9 187364 12788 63288861
Feeling jittery 15.81 10.42 10 187363 13393 63288256
Full blood count abnormal 15.79 10.42 153 187220 31564 63270085
Seroma 15.79 10.42 25 187348 2106 63299543
Chest injury 15.76 10.42 22 187351 1656 63299993
Pulmonary haematoma 15.75 10.42 8 187365 139 63301510
Injection site warmth 15.75 10.42 13 187360 15182 63286467
Crying 15.69 10.42 28 187345 23315 63278334
Hypertransaminasaemia 15.64 10.42 49 187324 6560 63295089
Prothrombin time shortened 15.61 10.42 24 187349 1971 63299678
Subacute cutaneous lupus erythematosus 15.59 10.42 28 187345 2615 63299034
Breath sounds abnormal 15.58 10.42 69 187304 10904 63290745
Musculoskeletal disorder 15.52 10.42 23 187350 20621 63281028
Shock symptom 15.51 10.42 6 187367 52 63301597
Defect conduction intraventricular 15.50 10.42 8 187365 144 63301505
Small fibre neuropathy 15.44 10.42 12 187361 451 63301198
Cardiac valve sclerosis 15.42 10.42 5 187368 24 63301625
Connective tissue inflammation 15.41 10.42 6 187367 53 63301596
Spinal disorder 15.40 10.42 5 187368 9897 63291752
Cerebrovascular arteriovenous malformation 15.39 10.42 7 187366 94 63301555
Red cell distribution width abnormal 15.35 10.42 8 187365 147 63301502
Fluid retention 15.33 10.42 108 187265 59578 63242071
Behaviour disorder 15.30 10.42 31 187342 3168 63298481
Procedural pain 15.29 10.42 25 187348 21544 63280105
Tooth abscess 15.28 10.42 13 187360 14956 63286693
Duodenal ulcer 15.24 10.42 54 187319 7702 63293947
Pharyngeal haemorrhage 15.23 10.42 13 187360 559 63301090
Orbital swelling 15.22 10.42 6 187367 55 63301594
Obstructive airways disorder 15.21 10.42 109 187264 20590 63281059
Blood sodium decreased 15.18 10.42 123 187250 24129 63277520
Atelectasis 15.14 10.42 25 187348 21458 63280191
Autoimmune disorder 15.12 10.42 17 187356 17160 63284489
Extensor plantar response 15.11 10.42 19 187354 1292 63300357
Platelet aggregation decreased 15.10 10.42 5 187368 26 63301623
Incorrect route of product administration 15.02 10.42 37 187336 27415 63274234
Hormone receptor positive HER2 negative breast cancer 15.02 10.42 8 187365 154 63301495
Hypernatraemia 14.97 10.42 53 187320 7556 63294093
Infusion site extravasation 14.96 10.42 6 187367 10420 63291229
Cardiomyopathy 14.95 10.42 96 187277 17488 63284161
Fear of eating 14.93 10.42 11 187362 381 63301268
Left atrial enlargement 14.89 10.42 10 187363 298 63301351
Bone disorder 14.86 10.42 25 187348 21301 63280348
Retroperitoneal fibrosis 14.86 10.42 10 187363 299 63301350
Injection site mass 14.81 10.42 20 187353 18636 63283013
Pulmonary embolism 14.79 10.42 450 186923 116234 63185415
Poisoning deliberate 14.78 10.42 69 187304 11149 63290500
Wrong strength 14.76 10.42 6 187367 60 63301589
Supraventricular tachycardia 14.76 10.42 82 187291 14189 63287460
Peripheral sensory neuropathy 14.75 10.42 52 187321 7399 63294250
X-ray abnormal 14.71 10.42 3 187370 8107 63293542
Pleurothotonus 14.68 10.42 19 187354 1330 63300319
Retrograde amnesia 14.63 10.42 12 187361 488 63301161
Intentional dose omission 14.62 10.42 3 187370 8072 63293577
Pharyngitis 14.61 10.42 23 187350 20120 63281529
Parkinsonian rest tremor 14.58 10.42 7 187366 107 63301542
Device dislocation 14.58 10.42 34 187339 25671 63275978
Polyserositis 14.56 10.42 11 187362 396 63301253
Renal aplasia 14.54 10.42 10 187363 310 63301339
Musculoskeletal toxicity 14.50 10.42 6 187367 63 63301586
Normochromic normocytic anaemia 14.50 10.42 38 187335 4598 63297051
Glomerular filtration rate abnormal 14.50 10.42 15 187358 824 63300825
Spinal ligament ossification 14.49 10.42 3 187370 0 63301649
Paranasal sinus haematoma 14.49 10.42 3 187370 0 63301649
Device breakage 14.48 10.42 8 187365 11534 63290115
Hysterectomy 14.42 10.42 5 187368 9494 63292155
General physical condition abnormal 14.37 10.42 36 187337 4238 63297411
Sudden cardiac death 14.36 10.42 24 187349 2116 63299533
Periorbital inflammation 14.34 10.42 6 187367 65 63301584
Bipolar disorder 14.32 10.42 3 187370 7957 63293692
Respiratory acidosis 14.28 10.42 48 187325 6667 63294982
Ventricular dysfunction 14.24 10.42 28 187345 2800 63298849
Femur fracture 14.22 10.42 69 187304 41687 63259962
Pneumonia viral 14.22 10.42 3 187370 7919 63293730
Chondrocalcinosis 14.22 10.42 15 187358 843 63300806
Tubulointerstitial nephritis 14.16 10.42 104 187269 19799 63281850
Body height decreased 14.14 10.42 6 187367 10072 63291577
Dystonia 14.11 10.42 12 187361 13807 63287842
Myoglobin blood increased 14.07 10.42 19 187354 1386 63300263
Myopathy toxic 14.02 10.42 12 187361 518 63301131
Condition aggravated 14.00 10.42 1010 186363 401207 62900442
Cholecystectomy 13.98 10.42 7 187366 10670 63290979
Peripheral venous disease 13.98 10.42 15 187358 15462 63286187
Calcification metastatic 13.94 10.42 8 187365 179 63301470
Weight decreased 13.94 10.42 671 186702 276127 63025522
Prohormone brain natriuretic peptide increased 13.86 10.42 8 187365 181 63301468
Page kidney 13.80 10.42 4 187369 12 63301637
Concussion 13.80 10.42 5 187368 9239 63292410
Finger deformity 13.77 10.42 3 187370 7742 63293907
Altered visual depth perception 13.76 10.42 10 187363 339 63301310
Ketonuria 13.74 10.42 13 187360 640 63301009
Anal polyp 13.72 10.42 6 187367 73 63301576
Postural tremor 13.71 10.42 10 187363 341 63301308
Liver function test abnormal 13.70 10.42 209 187164 47972 63253677
Bifascicular block 13.66 10.42 7 187366 124 63301525
Mood altered 13.64 10.42 14 187359 14729 63286920
Renal function test abnormal 13.60 10.42 32 187341 3621 63298028
Anaemia megaloblastic 13.58 10.42 11 187362 439 63301210
Anaphylactic reaction 13.58 10.42 127 187246 65973 63235676
Angiodermatitis 13.58 10.42 6 187367 75 63301574
Head injury 13.56 10.42 132 187241 27264 63274385
Mania 13.55 10.42 10 187363 12357 63289292
Eye pruritus 13.53 10.42 98 187275 18573 63283076
Premature delivery 13.50 10.42 45 187328 30236 63271413
Subdural haemorrhage 13.49 10.42 29 187344 3089 63298560
Vascular stenosis 13.48 10.42 10 187363 350 63301299
Bacterial infection 13.46 10.42 23 187350 19476 63282173
Product dose omission in error 13.43 10.42 3 187370 7609 63294040
Nerve compression 13.42 10.42 5 187368 9082 63292567
Cardiac arrest 13.41 10.42 363 187010 92182 63209467
Pyramidal tract syndrome 13.41 10.42 10 187363 353 63301296
Paroxysmal arrhythmia 13.38 10.42 5 187368 39 63301610
Infusion site erythema 13.38 10.42 9 187364 11670 63289979
Blood aldosterone increased 13.33 10.42 8 187365 195 63301454
Chronic sinusitis 13.30 10.42 11 187362 12832 63288817
Product complaint 13.23 10.42 11 187362 12798 63288851
Foetal death 13.22 10.42 8 187365 10972 63290677
Systolic hypertension 13.19 10.42 11 187362 458 63301191
Cerebellar syndrome 13.17 10.42 31 187342 3508 63298141
Intra-abdominal haematoma 13.13 10.42 21 187352 1784 63299865
Genital herpes zoster 13.13 10.42 4 187369 15 63301634
Eructation 13.07 10.42 54 187319 8279 63293370
Small for dates baby 13.04 10.42 32 187341 3719 63297930
Anticoagulation drug level increased 13.01 10.42 8 187365 204 63301445
Brain contusion 12.99 10.42 12 187361 573 63301076
Mucosal membrane hyperplasia 12.96 10.42 5 187368 43 63301606
Ocular hyperaemia 12.91 10.42 35 187338 25109 63276540
Coordination abnormal 12.84 10.42 77 187296 13696 63287953
Pruritus 12.84 10.42 906 186467 360547 62941102
Necrotising fasciitis 12.83 10.42 28 187345 3013 63298636
Injection site extravasation 12.83 10.42 5 187368 8836 63292813
Cardioactive drug level above therapeutic 12.81 10.42 7 187366 142 63301507
Spur cell anaemia 12.76 10.42 5 187368 45 63301604
Tongue oedema 12.75 10.42 36 187337 4550 63297099
Upper-airway cough syndrome 12.75 10.42 67 187306 11351 63290298
Peripheral circulatory failure 12.73 10.42 15 187358 953 63300696
Jaundice cholestatic 12.72 10.42 49 187324 7275 63294374
Cerebellar infarction 12.70 10.42 22 187351 1997 63299652
Limb discomfort 12.68 10.42 45 187328 29671 63271978
External ear disorder 12.67 10.42 5 187368 46 63301603
Brain natriuretic peptide increased 12.66 10.42 39 187334 5174 63296475
Peripheral coldness 12.64 10.42 70 187303 12095 63289554
Amaurosis 12.58 10.42 12 187361 597 63301052
Alanine aminotransferase increased 12.57 10.42 398 186975 103372 63198277
Peripartum cardiomyopathy 12.55 10.42 7 187366 148 63301501
Degenerative aortic valve disease 12.55 10.42 7 187366 148 63301501
Lupus-like syndrome 12.55 10.42 16 187357 15279 63286370
Hepatic function abnormal 12.52 10.42 166 187207 36976 63264673
Adrenal insufficiency 12.48 10.42 21 187352 17894 63283755
Product selection error 12.48 10.42 6 187367 92 63301557
Foot operation 12.46 10.42 3 187370 7228 63294421
Coloboma 12.43 10.42 6 187367 93 63301556
Blood lactate dehydrogenase 12.42 10.42 3 187370 3 63301646
Gastric atony 12.42 10.42 3 187370 3 63301646
Cardiac valve fibroelastoma 12.42 10.42 3 187370 3 63301646
Skin pressure mark 12.37 10.42 4 187369 19 63301630
Failure to thrive 12.37 10.42 3 187370 7195 63294454
Intervertebral disc degeneration 12.35 10.42 17 187356 15715 63285934
Onychomycosis 12.34 10.42 4 187369 7928 63293721
Ecchymosis 12.32 10.42 65 187308 11029 63290620
Intracardiac thrombus 12.30 10.42 24 187349 2386 63299263
Rotator cuff syndrome 12.29 10.42 13 187360 13489 63288160
Haematocrit decreased 12.27 10.42 67 187306 39273 63262376
Abdominal wall haemorrhage 12.27 10.42 7 187366 155 63301494
Paraparesis 12.23 10.42 23 187350 2225 63299424
Phaeochromocytoma 12.22 10.42 11 187362 508 63301141
Anal paraesthesia 12.21 10.42 4 187369 20 63301629
Genital paraesthesia 12.21 10.42 4 187369 20 63301629
Red blood cell sedimentation rate abnormal 12.18 10.42 25 187348 19757 63281892
Superinfection 12.16 10.42 25 187348 2582 63299067
Injection site induration 12.16 10.42 6 187367 9220 63292429
Body temperature decreased 12.15 10.42 102 187271 20217 63281432
Device leakage 12.11 10.42 3 187370 7093 63294556
Blindness cortical 12.07 10.42 11 187362 516 63301133
Nodal arrhythmia 12.06 10.42 16 187357 1147 63300502
Degenerative mitral valve disease 12.05 10.42 4 187369 21 63301628
Angiocardiogram 12.04 10.42 5 187368 53 63301596
Aortic valve incompetence 12.03 10.42 42 187331 5946 63295703
Respiratory tract congestion 12.02 10.42 92 187281 17740 63283909
Synovial cyst 12.01 10.42 8 187365 10425 63291224
Discoloured vomit 12.00 10.42 14 187359 880 63300769
Photophobia 11.99 10.42 21 187352 17614 63284035
Immune-mediated lung disease 11.98 10.42 12 187361 634 63301015
Peripheral artery thrombosis 11.97 10.42 21 187352 1925 63299724
Pre-eclampsia 11.94 10.42 6 187367 9127 63292522
Vertebrobasilar insufficiency 11.91 10.42 7 187366 164 63301485
Foetal growth restriction 11.89 10.42 49 187324 7504 63294145
Osteocalcin decreased 11.88 10.42 5 187368 55 63301594
Inflammation 11.87 10.42 171 187202 82102 63219547
Ischaemic cardiomyopathy 11.84 10.42 24 187349 2453 63299196
Caesarean section 11.84 10.42 20 187353 17012 63284637
Antipsychotic drug level above therapeutic 11.83 10.42 15 187358 1028 63300621
Gastritis erosive 11.83 10.42 42 187331 5997 63295652
Trifascicular block 11.83 10.42 6 187367 104 63301545
Throat irritation 11.81 10.42 64 187309 37583 63264066
Meningioma surgery 11.80 10.42 5 187368 56 63301593
Pulmonary vein occlusion 11.77 10.42 6 187367 105 63301544
Tachycardia induced cardiomyopathy 11.77 10.42 6 187367 105 63301544
Gamma-glutamyltransferase abnormal 11.77 10.42 9 187364 330 63301319
Cyanosis 11.77 10.42 88 187285 16847 63284802
Skin necrosis 11.76 10.42 76 187297 13874 63287775
Compensatory sweating 11.74 10.42 4 187369 23 63301626
Faecal volume decreased 11.69 10.42 7 187366 170 63301479
Genital candidiasis 11.69 10.42 7 187366 170 63301479
Ischaemic cerebral infarction 11.69 10.42 17 187356 1329 63300320
Back injury 11.68 10.42 7 187366 9653 63291996
Renin decreased 11.67 10.42 6 187367 107 63301542
Drug therapeutic incompatibility 11.65 10.42 5 187368 58 63301591
Hernia 11.56 10.42 12 187361 12562 63289087
Thirst 11.54 10.42 76 187297 13965 63287684
Splenic haematoma 11.53 10.42 6 187367 110 63301539
Adrenomegaly 11.53 10.42 6 187367 110 63301539
Pelvi-ureteric obstruction 11.51 10.42 7 187366 175 63301474
Brief psychotic disorder with marked stressors 11.50 10.42 5 187368 60 63301589
Hepatic fibrosis 11.49 10.42 30 187343 3622 63298027
Affect lability 11.48 10.42 64 187309 11087 63290562
Product substitution error 11.46 10.42 4 187369 25 63301624
Blindness 11.46 10.42 106 187267 21593 63280056
Haemothorax 11.45 10.42 22 187351 2163 63299486
Dyspnoea paroxysmal nocturnal 11.42 10.42 14 187359 927 63300722
Brain stem infarction 11.42 10.42 13 187360 796 63300853
Cardiomegaly 11.39 10.42 90 187283 17524 63284125
Kidney infection 11.35 10.42 33 187340 23143 63278506
Ventricular dyssynchrony 11.35 10.42 5 187368 62 63301587
Dry eye 11.35 10.42 72 187301 40689 63260960
Coma acidotic 11.33 10.42 6 187367 114 63301535
Hypercreatininaemia 11.32 10.42 11 187362 560 63301089
Walking aid user 11.32 10.42 9 187364 10708 63290941
Bronchiectasis 11.28 10.42 84 187289 16058 63285591
Facial paresis 11.28 10.42 29 187344 3469 63298180
Inflammatory marker increased 11.27 10.42 45 187328 6794 63294855
Stillbirth 11.24 10.42 3 187370 6747 63294902
Cerebellar haemorrhage 11.23 10.42 17 187356 1377 63300272
Adjusted calcium decreased 11.23 10.42 7 187366 183 63301466
Carbohydrate metabolism disorder 11.21 10.42 3 187370 6 63301643
Parapsoriasis 11.19 10.42 6 187367 117 63301532
Rhonchi 11.19 10.42 24 187349 2552 63299097
Carotid arteriosclerosis 11.14 10.42 15 187358 1091 63300558
Facial pain 11.13 10.42 61 187312 10500 63291149
Mixed liver injury 11.11 10.42 35 187338 4700 63296949
Drug abuse 11.08 10.42 149 187224 72369 63229280
Urogenital haemorrhage 11.07 10.42 8 187365 269 63301380
Peritoneal perforation 11.06 10.42 6 187367 120 63301529
Serratia infection 11.05 10.42 14 187359 959 63300690
Pain in jaw 11.02 10.42 79 187294 43417 63258232
Cerebral artery embolism 11.02 10.42 14 187359 962 63300687
Ileus paralytic 11.01 10.42 34 187339 4517 63297132
Mucosal atrophy 10.96 10.42 4 187369 29 63301620
Pleuritic pain 10.92 10.42 5 187368 8024 63293625
Gingival bleeding 10.88 10.42 69 187304 12518 63289131
Central nervous system inflammation 10.87 10.42 7 187366 194 63301455
Anticoagulation drug level above therapeutic 10.86 10.42 17 187356 1418 63300231
Heart valve incompetence 10.86 10.42 25 187348 2789 63298860
Ovarian cyst 10.83 10.42 19 187354 15926 63285723
Wrong drug 10.81 10.42 7 187366 196 63301453
Apathy 10.80 10.42 53 187320 8741 63292908
Compartment syndrome 10.77 10.42 22 187351 2262 63299387
Renal infarct 10.76 10.42 17 187356 1430 63300219
Electrocardiogram QT shortened 10.75 10.42 6 187367 127 63301522
Kidney malformation 10.75 10.42 6 187367 127 63301522
Resuscitation 10.75 10.42 15 187358 1129 63300520
Bullous haemorrhagic dermatosis 10.75 10.42 5 187368 71 63301578
Glaucoma 10.73 10.42 25 187348 18880 63282769
Somnolence 10.72 10.42 637 186736 178048 63123601
Eye infection 10.71 10.42 12 187361 12133 63289516
Chronic gastritis 10.70 10.42 25 187348 2816 63298833
Weight fluctuation 10.68 10.42 8 187365 9811 63291838
Hepatic necrosis 10.67 10.42 39 187334 5648 63296001
Cheyne-Stokes respiration 10.63 10.42 6 187367 130 63301519
Intertrigo 10.62 10.42 11 187362 605 63301044
Escherichia urinary tract infection 10.60 10.42 66 187307 11896 63289753
Rales 10.60 10.42 69 187304 12628 63289021
Hypokinesia 10.60 10.42 74 187299 13862 63287787
Chest wall haematoma 10.59 10.42 7 187366 203 63301446
Scoliosis 10.59 10.42 5 187368 7883 63293766
Joint injury 10.58 10.42 48 187325 29524 63272125
Cellulitis 10.58 10.42 174 187199 81784 63219865
Haemorrhagic infarction 10.57 10.42 8 187365 289 63301360
Coronavirus test positive 10.56 10.42 12 187361 733 63300916
Normochromic anaemia 10.54 10.42 8 187365 290 63301359
Mediastinitis 10.53 10.42 7 187366 205 63301444
Tardive dyskinesia 10.51 10.42 6 187367 8496 63293153
Anxiety disorder 10.50 10.42 31 187342 4019 63297630
Burns second degree 10.47 10.42 20 187353 1958 63299691
Chest wall mass 10.44 10.42 5 187368 76 63301573
Nephritis 10.43 10.42 23 187350 2493 63299156

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 828.08 10.89 3604 189786 301384 34462157
Bradycardia 760.03 10.89 1437 191953 73981 34689560
Cardiac failure 712.34 10.89 1564 191826 89684 34673857
Death 513.96 10.89 886 192504 397163 34366378
Hyperkalaemia 493.88 10.89 1147 192243 68242 34695299
Drug ineffective 445.43 10.89 1190 192200 455561 34307980
Drug interaction 426.97 10.89 2412 190978 223534 34540007
Atrial fibrillation 373.55 10.89 1502 191888 120891 34642650
Completed suicide 336.47 10.89 67 193323 98101 34665440
General physical health deterioration 296.49 10.89 1449 191941 126820 34636721
Product dose omission issue 284.30 10.89 154 193236 119557 34643984
Melaena 270.52 10.89 602 192788 34778 34728763
Syncope 248.82 10.89 1084 192306 90367 34673174
Hypotension 245.67 10.89 2077 191313 219572 34543969
Dyspnoea 228.10 10.89 3126 190264 373656 34389885
Off label use 218.52 10.89 1394 191996 418130 34345411
Ventricular tachycardia 217.67 10.89 465 192925 26114 34737427
Lactic acidosis 206.96 10.89 537 192853 34235 34729306
Cardiac failure chronic 204.61 10.89 235 193155 7644 34755897
Drug abuse 189.12 10.89 162 193228 98934 34664607
Disease progression 181.50 10.89 198 193192 107879 34655662
Mitral valve incompetence 173.36 10.89 303 193087 14640 34748901
Dyspnoea exertional 170.24 10.89 577 192813 42702 34720839
Sinus bradycardia 167.79 10.89 276 193114 12687 34750854
Systemic infection 167.65 10.89 174 193216 5038 34758503
Arrhythmia 166.86 10.89 506 192884 35302 34728239
Haematuria 165.03 10.89 630 192760 49436 34714105
White blood cell count decreased 162.31 10.89 173 193217 95272 34668269
Toxicity to various agents 161.45 10.89 568 192822 199794 34563747
Labelled drug-drug interaction medication error 156.80 10.89 290 193100 14649 34748892
Angina pectoris 156.40 10.89 454 192936 30909 34732632
N-terminal prohormone brain natriuretic peptide increased 150.70 10.89 123 193267 2592 34760949
Ejection fraction decreased 148.70 10.89 328 193062 18826 34744715
Neuropathy peripheral 148.29 10.89 145 193245 83118 34680423
Ischaemic stroke 145.63 10.89 316 193074 17934 34745607
Oedema peripheral 144.89 10.89 1146 192244 118666 34644875
Rales 143.83 10.89 222 193168 9661 34753880
Cerebral haemorrhage 142.01 10.89 471 192919 34466 34729075
Dyspnoea at rest 141.87 10.89 138 193252 3690 34759851
International normalised ratio increased 134.73 10.89 569 192821 46758 34716783
Shock haemorrhagic 130.11 10.89 229 193161 11125 34752416
Left ventricular dysfunction 129.43 10.89 213 193177 9794 34753747
Orthostatic hypotension 127.12 10.89 373 193017 25546 34737995
Febrile neutropenia 126.92 10.89 364 193026 136485 34627056
Electrocardiogram abnormal 123.90 10.89 200 193190 9047 34754494
Anaemia 121.62 10.89 1888 191502 231447 34532094
Mental status changes 120.36 10.89 31 193359 38052 34725489
Ventricular hypokinesia 118.64 10.89 150 193240 5402 34758139
Rectal haemorrhage 115.40 10.89 485 192905 39764 34723777
Presyncope 111.99 10.89 293 193097 18766 34744775
Atrial tachycardia 108.90 10.89 117 193273 3528 34760013
Platelet count decreased 108.39 10.89 322 193068 119395 34644146
Diastolic dysfunction 108.11 10.89 152 193238 6075 34757466
Pneumonia 107.13 10.89 1390 192000 361237 34402304
Atrioventricular block 106.14 10.89 173 193217 7890 34755651
Palpitations 105.57 10.89 470 192920 39516 34724025
Coronary artery stenosis 103.85 10.89 189 193201 9427 34754114
Hospitalisation 103.73 10.89 97 193293 56805 34706736
Haematoma 102.09 10.89 343 193047 25262 34738279
Nausea 100.33 10.89 1303 192087 338605 34424936
Rash 99.36 10.89 773 192617 221979 34541562
Seizure 98.58 10.89 277 193113 104580 34658961
Renal impairment 98.21 10.89 874 192516 93639 34669902
Treatment failure 97.03 10.89 70 193320 46627 34716914
Drug hypersensitivity 92.91 10.89 191 193199 80338 34683203
Pain 92.79 10.89 707 192683 203968 34559573
Sinusitis 91.46 10.89 58 193332 41344 34722197
Unevaluable event 91.32 10.89 33 193357 32557 34730984
Infusion related reaction 89.22 10.89 97 193293 52960 34710581
Subarachnoid haemorrhage 88.77 10.89 208 193182 12427 34751114
Fall 88.47 10.89 1595 191795 201290 34562251
Exercise tolerance decreased 86.00 10.89 124 193266 5074 34758467
Venous pressure jugular increased 85.45 10.89 54 193336 747 34762794
Acute myocardial infarction 84.68 10.89 548 192842 53171 34710370
Ventricular enlargement 84.22 10.89 50 193340 614 34762927
Circulatory collapse 84.02 10.89 282 193108 20756 34742785
Brain natriuretic peptide increased 83.58 10.89 128 193262 5531 34758010
Hypertensive crisis 83.33 10.89 163 193227 8588 34754953
Rhabdomyolysis 82.84 10.89 653 192737 67510 34696031
Subdural haematoma 82.69 10.89 275 193115 20146 34743395
Drug dispensed to wrong patient 81.31 10.89 45 193345 479 34763062
Atrioventricular block complete 80.87 10.89 167 193223 9152 34754389
Upper respiratory tract infection 80.63 10.89 41 193349 33018 34730523
Product use in unapproved indication 77.52 10.89 360 193030 117139 34646402
Wrong patient received product 77.20 10.89 84 193306 2570 34760971
Interstitial lung disease 76.38 10.89 620 192770 64662 34698879
Product use issue 76.30 10.89 146 193244 63070 34700471
Electrolyte imbalance 76.08 10.89 213 193177 14199 34749342
Cardiospasm 75.89 10.89 66 193324 1522 34762019
Palmoplantar keratoderma 75.38 10.89 72 193318 1881 34761660
Sopor 74.83 10.89 190 193200 11946 34751595
Ventricular arrhythmia 74.65 10.89 120 193270 5408 34758133
Injection site pain 74.06 10.89 64 193326 38941 34724600
Bradyarrhythmia 73.82 10.89 75 193315 2116 34761425
Inferior vena cava dilatation 73.09 10.89 48 193342 712 34762829
Occult blood 71.96 10.89 50 193340 818 34762723
Urogenital haemorrhage 71.52 10.89 47 193343 698 34762843
Pulmonary function test abnormal 71.42 10.89 80 193310 2530 34761011
Right atrial hypertrophy 70.58 10.89 48 193342 757 34762784
Therapeutic product effect decreased 69.70 10.89 54 193336 34689 34728852
Full blood count decreased 69.41 10.89 9 193381 18079 34745462
Drug resistance 68.11 10.89 29 193361 25898 34737643
Congestive cardiomyopathy 68.03 10.89 137 193253 7373 34756168
Sepsis 67.81 10.89 592 192798 165969 34597572
Acute coronary syndrome 67.43 10.89 196 193194 13349 34750192
Respiratory tract haemorrhage 67.27 10.89 56 193334 1214 34762327
Bronchial wall thickening 65.66 10.89 57 193333 1311 34762230
Headache 65.51 10.89 752 192638 199883 34563658
Drug dependence 65.38 10.89 26 193364 24191 34739350
Tricuspid valve incompetence 64.60 10.89 157 193233 9603 34753938
Electrocardiogram QT prolonged 64.06 10.89 417 192973 40535 34723006
Product prescribing error 63.17 10.89 273 193117 22654 34740887
No adverse event 62.91 10.89 24 193366 22903 34740638
Neutrophil count decreased 61.69 10.89 118 193272 50986 34712555
Chest pain 60.71 10.89 1012 192378 125750 34637791
Hypomagnesaemia 59.29 10.89 259 193131 21592 34741949
Hypoxia 59.12 10.89 136 193254 54959 34708582
Atrial flutter 58.89 10.89 205 193185 15369 34748172
Respiratory failure 58.59 10.89 356 193034 108216 34655325
Hyponatraemia 58.40 10.89 707 192683 81984 34681557
Pruritus genital 57.66 10.89 66 193324 2138 34761403
Vascular stent thrombosis 56.01 10.89 75 193315 2860 34760681
Stomatitis 55.96 10.89 93 193297 42421 34721120
Infection 55.63 10.89 286 193104 90629 34672912
Tension headache 55.42 10.89 76 193314 2966 34760575
Orthopnoea 54.72 10.89 100 193290 5003 34758538
Normocytic anaemia 54.37 10.89 66 193324 2278 34761263
Dizziness 53.87 10.89 1586 191804 216935 34546606
Minimum inhibitory concentration 53.12 10.89 24 193366 158 34763383
Cerebral haematoma 52.76 10.89 93 193297 4522 34759019
Nasopharyngitis 52.50 10.89 204 193186 69764 34693777
Foetal exposure during pregnancy 52.36 10.89 81 193309 38020 34725521
Antimicrobial susceptibility test resistant 52.29 10.89 30 193360 344 34763197
Immunisation 51.95 10.89 45 193345 1032 34762509
Cardiogenic shock 51.82 10.89 287 193103 26331 34737210
Sleep terror 51.72 10.89 64 193326 2254 34761287
Depression 51.53 10.89 320 193070 96778 34666763
Cerebral infarction 51.45 10.89 293 193097 27162 34736379
Systolic dysfunction 51.37 10.89 69 193321 2639 34760902
Hypokalaemia 51.29 10.89 520 192870 57694 34705847
Pyrexia 51.24 10.89 1427 191963 331586 34431955
Drug withdrawal syndrome 50.81 10.89 23 193367 19811 34743730
Ventricular extrasystoles 49.76 10.89 163 193227 11845 34751696
Oesophageal perforation 49.72 10.89 46 193344 1153 34762388
Pemphigoid 49.65 10.89 132 193258 8534 34755007
Atrial enlargement 49.46 10.89 36 193354 636 34762905
Glomerular filtration rate decreased 49.35 10.89 171 193219 12790 34750751
Arthralgia 49.18 10.89 654 192736 169387 34594154
Ischaemic cardiomyopathy 49.11 10.89 109 193281 6280 34757261
Right ventricular hypertrophy 48.95 10.89 51 193339 1483 34762058
Carotid artery occlusion 48.94 10.89 80 193310 3657 34759884
Therapeutic response decreased 48.82 10.89 54 193336 29259 34734282
Abnormal behaviour 48.59 10.89 40 193350 24929 34738612
Constipation 48.42 10.89 504 192886 136478 34627063
Fatigue 48.28 10.89 1624 191766 369029 34394512
Nephrolithiasis 48.22 10.89 58 193332 30275 34733266
Left ventricular hypertrophy 47.76 10.89 125 193265 8005 34755536
Vertigo 47.51 10.89 272 193118 25264 34738277
Stress 47.22 10.89 59 193331 30288 34733253
Bronchial secretion retention 47.11 10.89 50 193340 1486 34762055
Bundle branch block left 47.09 10.89 103 193287 5876 34757665
Aortic valve stenosis 46.95 10.89 66 193324 2637 34760904
Contraindicated product administered 46.87 10.89 239 193151 21242 34742299
Anuria 46.71 10.89 145 193245 10240 34753301
Product monitoring error 45.90 10.89 85 193305 4296 34759245
Facial pain 45.43 10.89 77 193313 3627 34759914
Upper gastrointestinal haemorrhage 45.00 10.89 268 193122 25250 34738291
Injection site erythema 44.70 10.89 16 193374 15883 34747658
Confusional state 44.58 10.89 1078 192312 143082 34620459
Therapy cessation 44.56 10.89 19 193371 16954 34746587
Blood pressure systolic decreased 44.24 10.89 85 193305 4418 34759123
Malignant neoplasm progression 43.75 10.89 296 193094 87750 34675791
Graft versus host disease 43.75 10.89 4 193386 10565 34752976
Hyperthyroidism 43.40 10.89 143 193247 10423 34753118
Cardiovascular insufficiency 43.26 10.89 50 193340 1637 34761904
Vascular purpura 42.77 10.89 51 193339 1727 34761814
Myoglobin blood increased 42.72 10.89 67 193323 2956 34760585
Haematochezia 42.60 10.89 419 192971 46115 34717426
Left atrial enlargement 42.02 10.89 37 193353 868 34762673
Lip swelling 41.66 10.89 188 193202 15892 34747649
Hepatojugular reflux 41.54 10.89 31 193359 570 34762971
Premature baby 41.34 10.89 29 193361 19604 34743937
Accidental exposure to product 41.26 10.89 10 193380 12792 34750749
Pathogen resistance 40.88 10.89 3 193387 9479 34754062
Hypoglycaemia 40.69 10.89 472 192918 54168 34709373
Deep vein thrombosis 40.62 10.89 204 193186 65044 34698497
Eosinophilia 40.38 10.89 266 193124 25956 34737585
Electrocardiogram PR prolongation 40.37 10.89 36 193354 859 34762682
Electrocardiogram Q wave abnormal 39.91 10.89 27 193363 422 34763119
Mitral valve thickening 38.17 10.89 25 193365 369 34763172
Hypersensitivity 37.89 10.89 191 193199 60844 34702697
Degenerative mitral valve disease 37.78 10.89 22 193368 260 34763281
Therapeutic response delayed 37.73 10.89 30 193360 608 34762933
Bone marrow failure 37.57 10.89 65 193325 29188 34734353
Irritability 37.38 10.89 49 193341 24641 34738900
Left ventricular enlargement 37.28 10.89 31 193359 671 34762870
Respiratory arrest 37.22 10.89 61 193329 27982 34735559
Cardiac murmur 36.72 10.89 111 193279 7726 34755815
Plasma cell myeloma 36.61 10.89 115 193275 41922 34721619
Incorrect dose administered 36.59 10.89 109 193281 40406 34723135
Blood creatinine increased 36.58 10.89 733 192657 94243 34669298
Cardiac failure acute 36.44 10.89 135 193255 10435 34753106
Flushing 36.43 10.89 78 193312 32342 34731199
Hemiparesis 36.15 10.89 178 193212 15600 34747941
Product quality issue 36.08 10.89 25 193365 17010 34746531
Cellulitis 35.62 10.89 161 193229 52790 34710751
Atrioventricular block second degree 35.39 10.89 70 193320 3718 34759823
Hypocalcaemia 35.37 10.89 243 193147 24046 34739495
Injection site reaction 35.16 10.89 14 193376 13019 34750522
Influenza 34.62 10.89 149 193241 49517 34714024
Monoparesis 34.55 10.89 53 193337 2293 34761248
Intestinal haemorrhage 34.36 10.89 66 193324 3430 34760111
Tachyarrhythmia 34.10 10.89 67 193323 3541 34760000
Pain of skin 33.94 10.89 92 193298 6017 34757524
Tachycardia 33.90 10.89 658 192732 84114 34679427
Rheumatoid arthritis 33.73 10.89 104 193286 38134 34725407
Nasal congestion 33.65 10.89 47 193343 23010 34740531
Anosmia 33.61 10.89 71 193319 3953 34759588
Thrombosis 33.59 10.89 154 193236 50304 34713237
Duodenal ulcer haemorrhage 33.56 10.89 81 193309 4932 34758609
Back pain 33.53 10.89 473 192917 121316 34642225
Pulmonary vascular disorder 33.48 10.89 29 193361 665 34762876
Staphylococcal infection 33.44 10.89 83 193307 32677 34730864
Blood glucose fluctuation 33.37 10.89 71 193319 3973 34759568
Therapeutic product effect incomplete 33.20 10.89 155 193235 50386 34713155
Jaundice 33.15 10.89 295 193095 31587 34731954
Multimorbidity 33.12 10.89 33 193357 909 34762632
Strangury 33.12 10.89 16 193374 125 34763416
Needle fatigue 33.10 10.89 32 193358 849 34762692
Decreased appetite 32.94 10.89 686 192704 165706 34597835
Epistaxis 32.78 10.89 478 192912 57773 34705768
Mucosal inflammation 32.70 10.89 107 193283 38515 34725026
Intraventricular haemorrhage 32.68 10.89 65 193325 3466 34760075
Cerebral ventricular rupture 32.65 10.89 18 193372 190 34763351
Cardiac aneurysm 32.60 10.89 33 193357 927 34762614
Arthropathy 32.57 10.89 62 193328 26845 34736696
Acute pulmonary oedema 32.54 10.89 102 193288 7241 34756300
Jugular vein distension 32.47 10.89 28 193362 638 34762903
Tremor 32.47 10.89 296 193094 82291 34681250
Chronic coronary syndrome 32.14 10.89 17 193373 164 34763377
Myocardial ischaemia 32.10 10.89 185 193205 17223 34746318
Bacteraemia 32.09 10.89 37 193353 19680 34743861
Neutropenia 32.03 10.89 643 192747 156135 34607406
Gout 31.92 10.89 199 193191 19054 34744487
Torsade de pointes 31.82 10.89 100 193290 7109 34756432
Metabolic acidosis 31.05 10.89 374 193016 43306 34720235
Abdominal distension 30.90 10.89 193 193197 58299 34705242
Psychotic disorder 30.79 10.89 55 193335 24397 34739144
ECG signs of myocardial ischaemia 30.79 10.89 17 193373 180 34763361
Drug intolerance 30.72 10.89 198 193192 59372 34704169
Synovitis 30.65 10.89 20 193370 14046 34749495
Renal failure 30.60 10.89 942 192448 129615 34633926
Ocular myasthenia 30.53 10.89 18 193372 218 34763323
Chills 30.35 10.89 294 193096 80749 34682792
Psoriatic arthropathy 30.27 10.89 39 193351 19759 34743782
Increased appetite 30.25 10.89 3 193387 7426 34756115
Aspergillus infection 30.17 10.89 15 193375 12239 34751302
Obstruction 30.07 10.89 54 193336 2665 34760876
Osteonecrosis 30.04 10.89 23 193367 14867 34748674
Inappropriate antidiuretic hormone secretion 30.02 10.89 145 193245 12608 34750933
Transient ischaemic attack 30.00 10.89 258 193132 27355 34736186
Psoriasis 29.85 10.89 112 193278 38700 34724841
Loss of consciousness 29.85 10.89 632 192758 82035 34681506
Erysipelas 29.83 10.89 76 193314 4787 34758754
Transplant rejection 29.64 10.89 10 193380 10301 34753240
Product dispensing error 29.52 10.89 89 193301 6185 34757356
Myelosuppression 29.40 10.89 38 193352 19227 34744314
Urticaria 29.36 10.89 213 193177 62164 34701377
Chronic kidney disease 29.35 10.89 353 193037 40857 34722684
Fractional exhaled nitric oxide increased 29.32 10.89 33 193357 1049 34762492
Carotid artery stenosis 29.31 10.89 77 193313 4942 34758599
Therapy non-responder 28.80 10.89 115 193275 39031 34724510
Small intestinal obstruction 28.69 10.89 24 193366 14842 34748699
Stenosis 28.66 10.89 38 193352 1435 34762106
Illness 28.46 10.89 20 193370 13509 34750032
Atrial thrombosis 28.46 10.89 47 193343 2167 34761374
Relapsing-remitting multiple sclerosis 28.41 10.89 32 193358 1018 34762523
Inflammatory marker increased 28.21 10.89 76 193314 4952 34758589
Hepatic vein dilatation 28.21 10.89 17 193373 215 34763326
Haematemesis 28.09 10.89 255 193135 27456 34736085
Hypersomnia 27.92 10.89 17 193373 12390 34751151
Sinoatrial block 27.89 10.89 23 193367 492 34763049
Pericardial haemorrhage 27.88 10.89 57 193333 3101 34760440
Therapy interrupted 27.84 10.89 21 193369 13676 34749865
Viral infection 27.69 10.89 34 193356 17589 34745952
Hypocoagulable state 27.62 10.89 30 193360 916 34762625
Soft tissue mass 27.48 10.89 31 193359 988 34762553
Faeces discoloured 27.36 10.89 158 193232 14720 34748821
Gait spastic 27.30 10.89 32 193358 1064 34762477
Appendicitis 27.25 10.89 25 193365 14782 34748759
Febrile infection 27.17 10.89 46 193344 2165 34761376
Injection site swelling 27.07 10.89 15 193375 11512 34752029
Respiratory depression 26.97 10.89 30 193360 16215 34747326
Extremity necrosis 26.89 10.89 43 193347 1929 34761612
Intentional product use issue 26.84 10.89 207 193183 59609 34703932
Musculoskeletal stiffness 26.78 10.89 150 193240 46530 34717011
Drug ineffective for unapproved indication 26.69 10.89 57 193333 23658 34739883
Blood thyroid stimulating hormone increased 26.63 10.89 67 193323 4188 34759353
Echocardiogram abnormal 26.41 10.89 31 193359 1032 34762509
Cardio-respiratory arrest 26.37 10.89 188 193202 55085 34708456
Haematoma muscle 26.17 10.89 35 193355 1333 34762208
Red cell distribution width increased 26.17 10.89 84 193306 6039 34757502
Duodenitis 26.11 10.89 72 193318 4756 34758785
Gravitational oedema 26.11 10.89 25 193365 655 34762886
Hypochromic anaemia 26.07 10.89 29 193361 910 34762631
Herpes zoster 25.98 10.89 100 193290 34299 34729242
Surgery 25.94 10.89 24 193366 14133 34749408
Embolic stroke 25.67 10.89 68 193322 4386 34759155
Renal injury 25.67 10.89 15 193375 11180 34752361
Device issue 25.57 10.89 11 193379 9766 34753775
Aspartate aminotransferase increased 25.33 10.89 246 193144 67537 34696004
Adrenal cyst 25.30 10.89 14 193376 149 34763392
Medication error 25.27 10.89 234 193156 25331 34738210
Aortic valve incompetence 25.24 10.89 81 193309 5823 34757718
Tongue oedema 25.17 10.89 53 193337 2944 34760597
Spinal cord haemorrhage 24.87 10.89 18 193372 315 34763226
Hypovolaemic shock 24.85 10.89 91 193299 6994 34756547
Aortic stenosis 24.58 10.89 66 193324 4292 34759249
Localised infection 24.53 10.89 37 193353 17550 34745991
Blood lactic acid 24.26 10.89 18 193372 328 34763213
Benign prostatic hyperplasia 24.14 10.89 150 193240 14345 34749196
C-reactive protein abnormal 24.09 10.89 9 193381 8701 34754840
Therapeutic drug monitoring analysis not performed 24.06 10.89 22 193368 543 34762998
Therapeutic response unexpected 23.94 10.89 12 193378 9745 34753796
Vascular stent stenosis 23.80 10.89 31 193359 1150 34762391
Fungal infection 23.74 10.89 32 193358 15903 34747638
Extrasystoles 23.72 10.89 60 193330 3763 34759778
Pericarditis 23.63 10.89 127 193263 11518 34752023
Head titubation 23.61 10.89 19 193371 392 34763149
Pallor 23.59 10.89 230 193160 25250 34738291
Cytomegalovirus viraemia 23.56 10.89 6 193384 7424 34756117
Exposure during pregnancy 23.45 10.89 10 193380 8924 34754617
Carotid arteriosclerosis 23.29 10.89 39 193351 1819 34761722
Poisoning 23.27 10.89 20 193370 12206 34751335
Hypochromasia 23.18 10.89 17 193373 304 34763237
Paranoia 22.66 10.89 20 193370 12048 34751493
Anaemia macrocytic 22.56 10.89 51 193339 2975 34760566
Cytokine release syndrome 22.55 10.89 59 193331 22818 34740723
Cerebellar haemorrhage 22.45 10.89 35 193355 1536 34762005
Nicotine dependence 22.38 10.89 22 193368 596 34762945
Gastritis erosive 22.35 10.89 78 193312 5854 34757687
Toxic skin eruption 22.32 10.89 123 193267 11262 34752279
Agranulocytosis 22.04 10.89 215 193175 23606 34739935
Eye pruritus 22.04 10.89 91 193299 7398 34756143
Discharge 21.91 10.89 17 193373 332 34763209
Knee arthroplasty 21.78 10.89 7 193383 7437 34756104
Muscle haemorrhage 21.67 10.89 57 193333 3661 34759880
Ventricular hyperkinesia 21.65 10.89 14 193376 202 34763339
Malaise 21.56 10.89 1245 192145 184580 34578961
Emotional distress 21.56 10.89 31 193359 14995 34748546
Supine hypertension 21.49 10.89 17 193373 342 34763199
Hepatotoxicity 21.49 10.89 55 193335 21430 34742111
Injection site pruritus 21.46 10.89 6 193384 6977 34756564
Haemothorax 21.39 10.89 58 193332 3794 34759747
Laboratory test abnormal 21.33 10.89 51 193339 20340 34743201
Helicobacter gastritis 21.20 10.89 30 193360 1206 34762335
Vomiting 21.17 10.89 1137 192253 246484 34517057
Cardioversion 21.16 10.89 26 193364 909 34762632
Immune reconstitution inflammatory syndrome 21.15 10.89 11 193379 8748 34754793
Hepatic function abnormal 21.11 10.89 151 193239 44212 34719329
Transferrin saturation decreased 21.08 10.89 19 193371 460 34763081
Peripheral arterial occlusive disease 21.07 10.89 76 193314 5798 34757743
Feeling abnormal 20.97 10.89 236 193154 62999 34700542
Hypokinesia 20.93 10.89 101 193289 8779 34754762
Weight decreased 20.89 10.89 781 192609 175520 34588021
Histamine level increased 20.89 10.89 9 193381 52 34763489
Helicobacter test positive 20.89 10.89 25 193365 850 34762691
Subdural haemorrhage 20.76 10.89 51 193339 3140 34760401
Dehydration 20.71 10.89 898 192492 129071 34634470
Anhedonia 20.71 10.89 8 193382 7577 34755964
Ejection fraction abnormal 20.67 10.89 26 193364 931 34762610
Hypertonic bladder 20.59 10.89 37 193353 1827 34761714
Heart sounds abnormal 20.55 10.89 25 193365 865 34762676
Atelectasis 20.46 10.89 42 193348 17685 34745856
Ear infection 20.39 10.89 16 193374 10215 34753326
Aggression 20.35 10.89 129 193261 38835 34724706
International normalised ratio abnormal 20.33 10.89 52 193338 3283 34760258
Chest X-ray abnormal 20.33 10.89 62 193328 4336 34759205
Retinal artery occlusion 20.29 10.89 37 193353 1848 34761693
Unresponsive to stimuli 20.27 10.89 81 193309 27488 34736053
Nuchal rigidity 20.19 10.89 19 193371 487 34763054
Abnormal loss of weight 20.18 10.89 59 193331 4031 34759510
Cholestasis 20.14 10.89 233 193157 26715 34736826
Neoplasm progression 20.10 10.89 64 193326 23236 34740305
Haemarthrosis 20.06 10.89 51 193339 3208 34760333
Crying 20.06 10.89 4 193386 5858 34757683
Postrenal failure 19.93 10.89 18 193372 437 34763104
Liver palpable 19.86 10.89 15 193375 281 34763260
Poisoning deliberate 19.79 10.89 91 193299 7753 34755788
Treatment noncompliance 19.76 10.89 84 193306 28016 34735525
Sensation of foreign body 19.75 10.89 46 193344 2737 34760804
Dermatitis atopic 19.72 10.89 3 193387 5344 34758197
Tendon rupture 19.70 10.89 84 193306 6928 34756613
Left ventricular failure 19.70 10.89 68 193322 5076 34758465
Osteomyelitis 19.69 10.89 37 193353 16099 34747442
Eye injury 19.62 10.89 24 193366 835 34762706
Wheezing 19.58 10.89 330 193060 41072 34722469
Granulocytopenia 19.53 10.89 6 193384 6561 34756980
Joint range of motion decreased 19.49 10.89 8 193382 7304 34756237
Intestinal obstruction 19.47 10.89 63 193327 22759 34740782
Immune thrombocytopenia 19.38 10.89 101 193289 9051 34754490
Myelodysplastic syndrome 19.34 10.89 49 193341 19159 34744382
Muscle spasms 19.33 10.89 295 193095 74706 34688835
Peripheral artery stenosis 19.33 10.89 24 193366 848 34762693
Epstein-Barr virus infection 19.30 10.89 9 193381 7619 34755922
Vision blurred 19.27 10.89 162 193228 45801 34717740
Cystitis haemorrhagic 19.18 10.89 4 193386 5675 34757866
Hyperkaliuria 19.13 10.89 10 193380 94 34763447
Syringe issue 19.10 10.89 4 193386 5660 34757881
Steatorrhoea 19.02 10.89 22 193368 721 34762820
Troponin T increased 18.85 10.89 41 193349 2330 34761211
Device pacing issue 18.74 10.89 8 193382 45 34763496
Influenza like illness 18.59 10.89 84 193306 27550 34735991
Cerebellar haematoma 18.59 10.89 13 193377 215 34763326
Procalcitonin abnormal 18.50 10.89 16 193374 366 34763175
Left ventricular dilatation 18.45 10.89 22 193368 745 34762796
Heart rate irregular 18.40 10.89 150 193240 15657 34747884
Mechanical urticaria 18.35 10.89 10 193380 103 34763438
Blood glucose decreased 18.32 10.89 28 193362 13209 34750332
Neck pain 18.31 10.89 75 193315 25274 34738267
Subacute cutaneous lupus erythematosus 18.20 10.89 25 193365 977 34762564
Back disorder 18.18 10.89 7 193383 6644 34756897
Leukocytosis 18.14 10.89 70 193320 23995 34739546
Neurotoxicity 18.09 10.89 46 193344 17964 34745577
Blood glucose abnormal 18.05 10.89 73 193317 5879 34757662
Wound 17.81 10.89 142 193248 14722 34748819
Oropharyngeal pain 17.76 10.89 119 193271 35366 34728175
Intracranial haematoma 17.74 10.89 17 193373 446 34763095
Bleeding time prolonged 17.72 10.89 20 193370 638 34762903
Immune-mediated myositis 17.69 10.89 37 193353 2046 34761495
Cold sweat 17.68 10.89 105 193285 9882 34753659
Osteochondrosis 17.66 10.89 26 193364 1084 34762457
Cardiac septal hypertrophy 17.56 10.89 14 193376 285 34763256
Brain stem infarction 17.54 10.89 28 193362 1254 34762287
Tongue disorder 17.54 10.89 4 193386 5335 34758206
Dyslipidaemia 17.53 10.89 85 193305 7403 34756138
Obstructive airways disorder 17.48 10.89 146 193244 15348 34748193
Periarthritis calcarea 17.46 10.89 9 193381 82 34763459
Prostate cancer 17.42 10.89 138 193252 39511 34724030
Injection site haemorrhage 17.38 10.89 17 193373 9751 34753790
Melanoderma 17.29 10.89 11 193379 154 34763387
Plantar fasciitis 17.29 10.89 37 193353 2079 34761462
Sedation 17.23 10.89 59 193331 20947 34742594
Visual acuity reduced 17.20 10.89 40 193350 16109 34747432
Disease recurrence 17.19 10.89 61 193329 21429 34742112
Articular calcification 17.18 10.89 9 193381 85 34763456
Laryngeal discomfort 17.13 10.89 12 193378 199 34763342
Genital herpes simplex 17.11 10.89 10 193380 119 34763422
Ventricular asystole 17.05 10.89 11 193379 158 34763383
Blood potassium decreased 17.05 10.89 47 193343 17868 34745673
Sinus node dysfunction 17.00 10.89 57 193333 4192 34759349
Sinus disorder 16.96 10.89 9 193381 7076 34756465
Alanine aminotransferase increased 16.92 10.89 330 193060 80485 34683056
Bacterial infection 16.82 10.89 44 193346 17019 34746522
Xyphoid retraction 16.82 10.89 11 193379 162 34763379
Subcutaneous haematoma 16.77 10.89 24 193366 975 34762566
Breath sounds abnormal 16.75 10.89 79 193311 6802 34756739
Injection site bruising 16.70 10.89 14 193376 8649 34754892
Hallucination, auditory 16.69 10.89 25 193365 11892 34751649
Vascular pseudoaneurysm 16.69 10.89 37 193353 2130 34761411
Scar 16.68 10.89 6 193384 5938 34757603
Drug reaction with eosinophilia and systemic symptoms 16.67 10.89 266 193124 32746 34730795
Skin pressure mark 16.61 10.89 8 193382 62 34763479
Troponin increased 16.61 10.89 114 193276 11275 34752266
Disorientation 16.61 10.89 267 193123 32921 34730620
Haemorrhagic stroke 16.60 10.89 76 193314 6463 34757078
Base excess decreased 16.58 10.89 12 193378 210 34763331
Anger 16.58 10.89 25 193365 11859 34751682
Respiratory syncytial virus infection 16.57 10.89 3 193387 4706 34758835
Pulmonary fibrosis 16.51 10.89 165 193225 18231 34745310
Product complaint 16.43 10.89 6 193384 5884 34757657
Encephalopathy 16.42 10.89 121 193269 35198 34728343
Polymerase chain reaction 16.41 10.89 9 193381 94 34763447
Inappropriate schedule of product administration 16.40 10.89 244 193146 62052 34701489
Tuberculosis 16.36 10.89 14 193376 8563 34754978
Venous pressure jugular decreased 16.31 10.89 7 193383 40 34763501
Traumatic intracranial haemorrhage 16.30 10.89 20 193370 698 34762843
Escherichia infection 16.30 10.89 13 193377 8232 34755309
Drug level fluctuating 16.22 10.89 17 193373 498 34763043
Enthesopathy 16.10 10.89 3 193387 4610 34758931
Amaurosis fugax 16.10 10.89 18 193372 568 34762973
Platelet distribution width increased 16.10 10.89 10 193380 134 34763407
Benign gastrointestinal neoplasm 16.03 10.89 10 193380 135 34763406
Abdominal wall haematoma 16.03 10.89 33 193357 1804 34761737
Hypoglycaemic coma 15.97 10.89 39 193351 2392 34761149
Electrocardiogram T wave inversion 15.97 10.89 37 193353 2194 34761347
Insomnia 15.96 10.89 445 192945 103462 34660079
Acute graft versus host disease 15.95 10.89 8 193382 6495 34757046
Procalcitonin increased 15.93 10.89 32 193358 1719 34761822
Facial asymmetry 15.88 10.89 14 193376 329 34763212
Blood creatine phosphokinase increased 15.88 10.89 342 193048 44515 34719026
Bronchitis 15.79 10.89 152 193238 41811 34721730
Procedural haemorrhage 15.70 10.89 39 193351 2418 34761123
Therapy partial responder 15.70 10.89 18 193372 9598 34753943
Anorectal discomfort 15.65 10.89 34 193356 1930 34761611
Atrioventricular block first degree 15.61 10.89 71 193319 6021 34757520
Pneumonia fungal 15.60 10.89 10 193380 7090 34756451
Dyspnoea paroxysmal nocturnal 15.60 10.89 29 193361 1470 34762071
Infusion site induration 15.57 10.89 12 193378 232 34763309
Hemiataxia 15.50 10.89 7 193383 46 34763495
Therapeutic response shortened 15.50 10.89 11 193379 7393 34756148
Glomerular filtration rate 15.48 10.89 9 193381 106 34763435
Anxiety 15.48 10.89 425 192965 99003 34664538
Night sweats 15.44 10.89 47 193343 17305 34746236
Hyperammonaemia 15.37 10.89 8 193382 6359 34757182
Basilar artery thrombosis 15.35 10.89 12 193378 237 34763304
Leptotrichia infection 15.32 10.89 8 193382 75 34763466
Puncture site haematoma 15.30 10.89 10 193380 147 34763394
Infected skin ulcer 15.30 10.89 30 193360 1583 34761958
Blood creatine increased 15.24 10.89 61 193329 4890 34758651
Flagellate dermatitis 15.23 10.89 8 193382 76 34763465
Hepatitis B 15.23 10.89 7 193383 5976 34757565
Osteopenia 15.22 10.89 4 193386 4845 34758696
Cardiomyopathy 15.20 10.89 151 193239 16657 34746884
Cardioactive drug level increased 15.17 10.89 31 193359 1686 34761855
Substance abuse 15.16 10.89 12 193378 7629 34755912
Documented hypersensitivity to administered product 15.16 10.89 13 193377 294 34763247
Adenomatous polyposis coli 15.13 10.89 10 193380 150 34763391
Concomitant disease progression 15.08 10.89 39 193351 2479 34761062
Tooth disorder 15.08 10.89 23 193367 10859 34752682
Glycosylated haemoglobin increased 14.99 10.89 111 193279 11249 34752292
Cytomegalovirus infection 14.98 10.89 84 193306 26051 34737490
Gamma-glutamyltransferase increased 14.94 10.89 236 193154 28995 34734546
Blood pressure decreased 14.93 10.89 382 193008 51133 34712408
Haematotoxicity 14.89 10.89 14 193376 8180 34755361
Atypical fibroxanthoma 14.84 10.89 11 193379 200 34763341
Blood potassium increased 14.83 10.89 148 193242 16347 34747194
Coronary artery disease 14.83 10.89 361 193029 47944 34715597
Disability 14.82 10.89 4 193386 4761 34758780
Liver function test abnormal 14.81 10.89 248 193142 30826 34732715
Colorectal cancer 14.80 10.89 4 193386 4757 34758784
Right atrial enlargement 14.77 10.89 12 193378 251 34763290
Oropharyngeal swelling 14.77 10.89 16 193374 487 34763054
Vasculitis 14.70 10.89 110 193280 11186 34752355
Physical examination abnormal 14.69 10.89 13 193377 307 34763234
Fear 14.65 10.89 22 193368 10454 34753087
Lower gastrointestinal haemorrhage 14.62 10.89 96 193294 9356 34754185
Subarachnoid haematoma 14.62 10.89 12 193378 255 34763286
Rhinovirus infection 14.57 10.89 3 193387 4296 34759245
Diarrhoea 14.52 10.89 1913 191477 387999 34375542
Phlebitis infective 14.46 10.89 9 193381 121 34763420
Femoral artery aneurysm 14.42 10.89 10 193380 163 34763378
Muscle twitching 14.38 10.89 102 193288 10196 34753345
Urinary hesitation 14.38 10.89 41 193349 2761 34760780
Hepatitis C 14.38 10.89 20 193370 9810 34753731
Prostatic specific antigen increased 14.36 10.89 38 193352 14642 34748899
Dialysis 14.30 10.89 25 193365 11183 34752358
Bronchopulmonary aspergillosis 14.30 10.89 38 193352 14621 34748920
Arthritis 14.28 10.89 108 193282 31238 34732303
Small for dates baby 14.25 10.89 51 193339 3876 34759665
Endoscopy upper gastrointestinal tract abnormal 14.24 10.89 7 193383 57 34763484
Vertebrobasilar insufficiency 14.15 10.89 9 193381 126 34763415
Multiple drug therapy 14.13 10.89 15 193375 446 34763095
Haemoglobin urine present 14.09 10.89 9 193381 127 34763414
Angiogram 14.08 10.89 11 193379 217 34763324
Haemoptysis 14.07 10.89 272 193118 34734 34728807
Emotional disorder 14.07 10.89 7 193383 5709 34757832
Retinal phototoxicity 14.06 10.89 4 193386 4 34763537
Drug use disorder 14.05 10.89 3 193387 4188 34759353
Loss of proprioception 14.04 10.89 14 193376 386 34763155
Cardiac amyloidosis 14.03 10.89 25 193365 1226 34762315
Primary hypoparathyroidism 14.02 10.89 6 193384 34 34763507
Renal disorder 14.01 10.89 83 193307 25397 34738144
Hypoparathyroidism 13.98 10.89 17 193373 588 34762953
Cytopenia 13.97 10.89 31 193359 12692 34750849
Pulmonary valve disease 13.92 10.89 13 193377 330 34763211
Endocarditis 13.89 10.89 72 193318 6439 34757102
Hyperuricaemia 13.88 10.89 84 193306 7959 34755582
Seasonal allergy 13.87 10.89 10 193380 6665 34756876
Poikiloderma 13.87 10.89 10 193380 174 34763367
Nightmare 13.86 10.89 131 193259 14260 34749281
Immature granulocyte count increased 13.85 10.89 9 193381 131 34763410
Right ventricular dysfunction 13.84 10.89 24 193366 1152 34762389
Acne 13.83 10.89 25 193365 11041 34752500
Hypoaesthesia 13.75 10.89 248 193142 61196 34702345
Hepatic enzyme increased 13.69 10.89 144 193246 38936 34724605
Photosensitivity reaction 13.69 10.89 103 193287 10491 34753050
Sexual dysfunction 13.68 10.89 9 193381 6294 34757247
Blood chloride increased 13.68 10.89 41 193349 2840 34760701
Crystalluria 13.60 10.89 15 193375 466 34763075
Staphylococcal bacteraemia 13.60 10.89 16 193374 8436 34755105
Tricuspid valve calcification 13.60 10.89 4 193386 5 34763536
Multiple organ dysfunction syndrome 13.59 10.89 321 193069 76245 34687296
Gastrointestinal adenocarcinoma 13.56 10.89 7 193383 64 34763477
Lipid metabolism disorder 13.50 10.89 13 193377 343 34763198
Plasma cell myeloma recurrent 13.42 10.89 4 193386 4461 34759080
Obsessive-compulsive disorder 13.42 10.89 7 193383 5557 34757984
Bone disorder 13.32 10.89 9 193381 6206 34757335
Hiccups 13.31 10.89 22 193368 10060 34753481
Nephroangiosclerosis 13.30 10.89 10 193380 186 34763355
Pseudohyponatraemia 13.28 10.89 7 193383 67 34763474
Mania 13.27 10.89 20 193370 9491 34754050
Urinary retention 13.27 10.89 278 193112 36010 34727531
Osteoma 13.15 10.89 8 193382 103 34763438
Gastroenteritis viral 13.14 10.89 12 193378 7112 34756429
Hip fracture 13.14 10.89 29 193361 11896 34751645
Adrenomegaly 13.11 10.89 13 193377 356 34763185
Oesophageal infection 13.09 10.89 12 193378 297 34763244
Polycystic liver disease 13.09 10.89 8 193382 104 34763437
Brain natriuretic peptide abnormal 13.08 10.89 13 193377 357 34763184
Type 2 diabetes mellitus 13.07 10.89 141 193249 15891 34747650
Traumatic haematoma 13.06 10.89 18 193372 706 34762835
C-reactive protein decreased 13.03 10.89 32 193358 1970 34761571
Aplastic anaemia 13.02 10.89 21 193369 9695 34753846
Lymphadenopathy 13.00 10.89 98 193292 28365 34735176
Product administration error 12.98 10.89 143 193247 16201 34747340
Ammonia increased 12.98 10.89 4 193386 4365 34759176
Renal tubular acidosis 12.96 10.89 35 193355 2284 34761257
Hyperlipasaemia 12.96 10.89 15 193375 492 34763049
Macular ischaemia 12.94 10.89 7 193383 71 34763470
Swelling 12.93 10.89 161 193229 42205 34721336
Haemorrhage subcutaneous 12.91 10.89 35 193355 2289 34761252
Glomerular filtration rate increased 12.90 10.89 14 193376 427 34763114
Oliguria 12.89 10.89 85 193305 8295 34755246
Drop attacks 12.85 10.89 16 193374 567 34762974
Gait inability 12.85 10.89 65 193325 20693 34742848
Post procedural haematoma 12.83 10.89 27 193363 1499 34762042
Rapid correction of hyponatraemia 12.83 10.89 8 193382 108 34763433
Mucosal haemorrhage 12.80 10.89 28 193362 1597 34761944
Erosive duodenitis 12.79 10.89 29 193361 1695 34761846
Graft versus host disease in skin 12.78 10.89 3 193387 3922 34759619
Cardiac dysfunction 12.78 10.89 35 193355 2303 34761238
Body mass index increased 12.73 10.89 22 193368 1053 34762488
Generalised tonic-clonic seizure 12.72 10.89 67 193323 21107 34742434
Gastrointestinal haemorrhage 12.71 10.89 605 192785 87872 34675669
Brain contusion 12.70 10.89 19 193371 804 34762737
Rash vesicular 12.70 10.89 39 193351 2738 34760803
Low birth weight baby 12.68 10.89 15 193375 7890 34755651
Postictal paralysis 12.67 10.89 11 193379 253 34763288
Pericardial disease 12.67 10.89 14 193376 436 34763105
Cogwheel rigidity 12.65 10.89 25 193365 1327 34762214
Purpura 12.63 10.89 99 193291 10212 34753329
Tuberculosis bladder 12.61 10.89 3 193387 0 34763541
Suspected product quality issue 12.61 10.89 9 193381 154 34763387
Traumatic ulcer 12.61 10.89 3 193387 0 34763541
Neonatal deafness 12.61 10.89 3 193387 0 34763541
Catatonia 12.60 10.89 6 193384 5019 34758522
Glycosylated haemoglobin decreased 12.59 10.89 13 193377 374 34763167
Disseminated intravascular coagulation 12.57 10.89 70 193320 21746 34741795
Gastroduodenal ulcer 12.56 10.89 13 193377 375 34763166
Blood loss anaemia 12.54 10.89 83 193307 8111 34755430
Fluid intake reduced 12.53 10.89 47 193343 3654 34759887
Adrenal insufficiency 12.53 10.89 38 193352 14009 34749532
Complication associated with device 12.47 10.89 9 193381 5997 34757544
Drug level decreased 12.47 10.89 15 193375 7831 34755710
Thalamus haemorrhage 12.47 10.89 21 193369 984 34762557
Haemorrhage intracranial 12.42 10.89 139 193251 15807 34747734
Mydriasis 12.42 10.89 13 193377 7224 34756317
Uveitis 12.41 10.89 14 193376 7521 34756020
Subcutaneous abscess 12.39 10.89 3 193387 3840 34759701
Extradural haematoma 12.37 10.89 23 193367 1166 34762375
Akathisia 12.37 10.89 16 193374 8093 34755448
Blood cholesterol increased 12.34 10.89 65 193325 20478 34743063
Splenic necrosis 12.34 10.89 8 193382 116 34763425
Shock 12.27 10.89 195 193195 23984 34739557
Lung neoplasm malignant 12.23 10.89 52 193338 17343 34746198
Perihepatic abscess 12.22 10.89 8 193382 118 34763423
Gastrointestinal angiodysplasia 12.21 10.89 16 193374 597 34762944
Angina unstable 12.20 10.89 108 193282 11545 34751996
Body temperature increased 12.16 10.89 52 193338 17316 34746225
Concomitant disease aggravated 12.13 10.89 63 193327 5638 34757903
Joint injury 12.13 10.89 20 193370 9153 34754388
Reticulocytosis 12.11 10.89 11 193379 269 34763272
Hyperkinetic heart syndrome 12.11 10.89 8 193382 120 34763421
Haemodialysis 12.10 10.89 25 193365 10501 34753040
Anaemia of malignant disease 12.07 10.89 14 193376 460 34763081
Foot deformity 12.03 10.89 5 193385 4532 34759009
Faeces pale 12.00 10.89 25 193365 1378 34762163
Muscle tightness 11.99 10.89 6 193384 4878 34758663
Nodule 11.98 10.89 12 193378 6807 34756734
Conduction disorder 11.95 10.89 32 193358 2078 34761463
Laryngeal haematoma 11.94 10.89 9 193381 168 34763373
Hepatic cancer 11.94 10.89 17 193373 8258 34755283
Subclavian artery occlusion 11.94 10.89 8 193382 123 34763418
Diverticulum intestinal haemorrhagic 11.90 10.89 36 193354 2506 34761035
Orthostatic hypertension 11.88 10.89 11 193379 276 34763265
Diffuse vasculitis 11.86 10.89 7 193383 85 34763456
Aortic dissection 11.85 10.89 38 193352 2730 34760811
Vasculitic rash 11.85 10.89 20 193370 939 34762602
Periorbital haematoma 11.83 10.89 12 193378 338 34763203
Candida infection 11.82 10.89 54 193336 17661 34745880
Cardiac tamponade 11.77 10.89 59 193331 5207 34758334
Haemoglobin decreased 11.75 10.89 547 192843 120225 34643316
Arterial intramural haematoma 11.70 10.89 6 193384 54 34763487
Rash papular 11.67 10.89 97 193293 10181 34753360
Prolonged expiration 11.67 10.89 10 193380 226 34763315
Haemophagocytic lymphohistiocytosis 11.64 10.89 35 193355 12938 34750603
Peritonitis bacterial 11.62 10.89 10 193380 6100 34757441
Thyroiditis 11.58 10.89 34 193356 2328 34761213
Hypochloraemia 11.58 10.89 16 193374 629 34762912
Splenic cyst 11.56 10.89 8 193382 130 34763411
Ill-defined disorder 11.45 10.89 39 193351 13870 34749671
Renal-limited thrombotic microangiopathy 11.45 10.89 7 193383 91 34763450
Apparent death 11.45 10.89 3 193387 3641 34759900
Intrapericardial thrombosis 11.42 10.89 6 193384 57 34763484
Head injury 11.41 10.89 152 193238 18008 34745533
Vitamin D deficiency 11.39 10.89 69 193321 6539 34757002
Cerebrospinal fluid circulation disorder 11.33 10.89 4 193386 12 34763529
Tooth extraction 11.32 10.89 6 193384 4722 34758819
Genitourinary symptom 11.32 10.89 5 193385 31 34763510
Microcytic anaemia 11.25 10.89 34 193356 2366 34761175
Joint swelling 11.22 10.89 249 193141 59641 34703900
Pneumonitis chemical 11.21 10.89 9 193381 185 34763356
Adverse event 11.19 10.89 60 193330 18817 34744724
Hirsutism 11.17 10.89 9 193381 186 34763355
Superinfection 11.17 10.89 35 193355 2484 34761057
Blood pressure ambulatory increased 11.16 10.89 6 193384 60 34763481
Gastrointestinal disorder 11.13 10.89 127 193263 33821 34729720
Post-traumatic headache 11.08 10.89 6 193384 61 34763480
Hypogammaglobulinaemia 11.07 10.89 16 193374 7724 34755817
Bladder diverticulum 11.07 10.89 7 193383 97 34763444
Eczema infected 11.06 10.89 5 193385 33 34763508
Basal ganglia haemorrhage 11.03 10.89 19 193371 907 34762634
Necrotising retinitis 10.99 10.89 18 193372 824 34762717
Cardiac autonomic neuropathy 10.91 10.89 6 193384 63 34763478
Anticoagulation drug level above therapeutic 10.90 10.89 31 193359 2085 34761456
Angiocardiogram 10.89 10.89 9 193381 193 34763348

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 2512.26 10.08 6360 340008 513044 78884976
Bradycardia 1981.24 10.08 2683 343685 132874 79265146
Cardiac failure 1459.81 10.08 2500 343868 152342 79245678
Hyperkalaemia 1220.15 10.08 1953 344415 112445 79285575
Drug interaction 1178.80 10.08 4219 342149 410964 78987056
Atrial fibrillation 936.71 10.08 2409 343959 195477 79202543
General physical health deterioration 783.06 10.08 2801 343567 272437 79125583
Drug ineffective 732.20 10.08 2342 344026 1078571 78319449
Completed suicide 720.32 10.08 105 346263 245662 79152358
Hypotension 681.62 10.08 3734 342634 436583 78961437
Melaena 650.72 10.08 1041 345327 59849 79338171
Syncope 601.30 10.08 1930 344438 177519 79220501
Lactic acidosis 597.50 10.08 1086 345282 69273 79328747
Hyponatraemia 567.26 10.08 1881 344487 175967 79222053
Anaemia 507.40 10.08 3488 342880 441527 78956493
Pain 486.12 10.08 1509 344859 702293 78695727
Sinusitis 441.56 10.08 149 346219 195352 79202668
Product dose omission issue 416.67 10.08 282 346086 247255 79150765
International normalised ratio increased 403.94 10.08 1035 345333 83686 79314334
Hand deformity 392.53 10.08 13 346355 103906 79294114
Infusion related reaction 390.58 10.08 260 346108 229977 79168043
Death 381.34 10.08 1228 345140 565286 78832734
Cerebral haemorrhage 374.06 10.08 795 345573 56878 79341142
Sinus bradycardia 373.06 10.08 503 345865 24744 79373276
Systemic infection 363.51 10.08 317 346051 9435 79388585
Arthropathy 361.73 10.08 158 346210 176953 79221067
Ischaemic stroke 361.53 10.08 572 345796 32559 79365461
Dyspnoea 352.98 10.08 5446 340922 851579 78546441
Synovitis 350.72 10.08 109 346259 150625 79247395
Therapeutic product effect decreased 347.83 10.08 138 346230 163725 79234295
Arrhythmia 342.64 10.08 796 345572 60476 79337544
Cardiac failure chronic 340.71 10.08 324 346044 10811 79387209
Pemphigus 336.50 10.08 25 346343 99557 79298463
Renal impairment 334.95 10.08 1466 344902 156317 79241703
Treatment failure 331.27 10.08 163 346205 170323 79227697
Glossodynia 319.74 10.08 37 346331 103300 79294720
Ventricular tachycardia 318.20 10.08 617 345751 41318 79356702
Drug hypersensitivity 314.55 10.08 508 345860 298408 79099612
Systemic lupus erythematosus 313.29 10.08 71 346297 121078 79276942
Atrioventricular block 310.49 10.08 343 346025 13698 79384322
Maternal exposure during pregnancy 308.34 10.08 104 346264 136434 79261586
Rhabdomyolysis 305.85 10.08 1065 345303 102066 79295954
Swelling 299.98 10.08 299 346069 216412 79181608
Joint swelling 294.00 10.08 501 345867 288145 79109875
Haematoma 286.28 10.08 673 345695 51522 79346498
Mitral valve incompetence 278.89 10.08 469 345899 28096 79369924
Drug intolerance 278.66 10.08 448 345920 263671 79134349
Product use issue 276.33 10.08 302 346066 209520 79188500
Shock haemorrhagic 275.80 10.08 386 345982 19674 79378346
Off label use 275.67 10.08 2568 343800 904647 78493373
Hypertensive crisis 271.29 10.08 390 345978 20380 79377640
Nasopharyngitis 271.27 10.08 427 345941 253454 79144566
Product prescribing error 270.34 10.08 600 345768 44213 79353807
Atrioventricular block complete 270.27 10.08 347 346021 16263 79381757
Arthralgia 264.15 10.08 1433 344935 570370 78827650
Left ventricular dysfunction 263.88 10.08 371 345997 18990 79379030
Haematuria 260.57 10.08 773 345595 68063 79329957
Rectal haemorrhage 257.36 10.08 823 345545 75477 79322543
Oedema peripheral 247.99 10.08 1910 344458 250378 79147642
Angina pectoris 245.48 10.08 631 345737 51101 79346919
Fall 244.45 10.08 3210 343158 484419 78913601
Sopor 242.32 10.08 479 345889 32531 79365489
Rheumatoid arthritis 241.86 10.08 331 346037 208139 79189881
Subarachnoid haemorrhage 237.93 10.08 401 345967 24064 79373956
Helicobacter infection 234.07 10.08 18 346350 69686 79328334
Ejection fraction decreased 231.56 10.08 483 345885 34094 79363926
Orthostatic hypotension 231.20 10.08 650 345718 55514 79342506
Circulatory collapse 230.21 10.08 507 345861 37161 79360859
Presyncope 230.21 10.08 534 345834 40520 79357500
Labelled drug-drug interaction medication error 229.82 10.08 423 345945 27227 79370793
Hypokalaemia 229.68 10.08 1233 345135 142807 79255213
Injection site pain 227.75 10.08 141 346227 129697 79268323
Exposure during pregnancy 226.64 10.08 78 346290 101054 79296966
Abdominal discomfort 225.48 10.08 469 345899 250258 79147762
Duodenal ulcer perforation 222.61 10.08 17 346351 66194 79331826
Electrocardiogram QT prolonged 220.81 10.08 877 345491 89509 79308511
Hypomagnesaemia 218.26 10.08 568 345800 46343 79351677
Rash 216.46 10.08 1547 344821 576811 78821209
Subdural haematoma 216.26 10.08 444 345924 30990 79367030
Alopecia 214.64 10.08 425 345943 230930 79167090
Hypoglycaemia 213.24 10.08 941 345427 100653 79297367
Hypersensitivity 211.07 10.08 521 345847 261718 79136302
Confusional state 210.98 10.08 2210 344158 315787 79082233
Cardiogenic shock 203.79 10.08 516 345852 41398 79356622
Disease progression 200.76 10.08 306 346062 184056 79213964
Bradyarrhythmia 198.85 10.08 156 346212 3990 79394030
White blood cell count decreased 196.98 10.08 321 346047 187967 79210053
Irritable bowel syndrome 195.77 10.08 21 346347 62220 79335800
Renal failure 193.24 10.08 1514 344854 199454 79198566
Injection site erythema 192.07 10.08 51 346317 78146 79319874
Electrocardiogram abnormal 188.17 10.08 293 346075 16444 79381576
Headache 187.74 10.08 1875 344493 651897 78746123
Acute myocardial infarction 186.17 10.08 745 345623 76291 79321729
N-terminal prohormone brain natriuretic peptide increased 182.14 10.08 157 346211 4598 79393422
Infection 175.71 10.08 505 345863 241207 79156813
Sleep disorder due to general medical condition, insomnia type 173.80 10.08 3 346365 43553 79354467
Atrial tachycardia 173.04 10.08 183 346185 6950 79391070
Mental status changes 171.57 10.08 40 346328 66919 79331101
Stomatitis 169.17 10.08 234 346134 146523 79251497
Acute coronary syndrome 167.75 10.08 317 346051 20816 79377204
Dehydration 165.04 10.08 1726 344642 246461 79151559
Upper gastrointestinal haemorrhage 164.54 10.08 473 345895 40907 79357113
Fibromyalgia 163.74 10.08 39 346329 64301 79333719
Discomfort 161.80 10.08 184 346184 125433 79272587
Electrolyte imbalance 161.55 10.08 391 345977 30490 79367530
Upper respiratory tract infection 161.27 10.08 98 346270 91070 79306950
Haematochezia 160.43 10.08 780 345588 86865 79311155
Anuria 158.47 10.08 308 346060 20655 79377365
Rheumatoid factor positive 156.83 10.08 34 346334 59805 79338215
Dyspnoea exertional 156.58 10.08 771 345597 86302 79311718
Dyspnoea at rest 155.64 10.08 175 346193 7127 79390893
Drug abuse 154.19 10.08 295 346073 162396 79235624
Psoriatic arthropathy 153.84 10.08 73 346295 77926 79320094
Neuropathy peripheral 152.40 10.08 236 346132 141069 79256951
Toxicity to various agents 151.98 10.08 1139 345229 420401 78977619
Muscle injury 151.17 10.08 17 346351 48544 79349476
Folliculitis 148.16 10.08 30 346338 55350 79342670
Haematemesis 145.68 10.08 529 345839 51735 79346285
Cardiospasm 140.87 10.08 116 346252 3185 79394835
Cerebral infarction 138.21 10.08 475 345893 45201 79352819
Palmoplantar keratoderma 136.90 10.08 120 346248 3596 79394424
Coronary artery stenosis 136.81 10.08 216 346152 12268 79385752
Product monitoring error 133.94 10.08 179 346189 8727 79389293
Hepatic enzyme increased 133.78 10.08 380 345988 182230 79215790
Tachyarrhythmia 133.51 10.08 158 346210 6804 79391216
Palpitations 131.81 10.08 972 345396 125638 79272382
Injection site pruritus 131.12 10.08 15 346353 42268 79355752
International normalised ratio fluctuation 128.17 10.08 112 346256 3342 79394678
Atrial flutter 126.43 10.08 286 346082 21339 79376681
Musculoskeletal stiffness 126.14 10.08 367 346001 174641 79223379
Injection site reaction 124.91 10.08 41 346327 54744 79343276
Ventricular hypokinesia 123.76 10.08 176 346192 9103 79388917
Wrong patient received product 121.96 10.08 124 346244 4494 79393526
Rales 120.83 10.08 268 346100 19733 79378287
Torsade de pointes 120.33 10.08 262 346106 19050 79378970
Interstitial lung disease 118.09 10.08 866 345502 111734 79286286
Jaundice 117.91 10.08 502 345866 52847 79345173
Pruritus genital 117.64 10.08 120 346248 4366 79393654
Hospitalisation 117.09 10.08 142 346226 94094 79303926
C-reactive protein abnormal 114.21 10.08 34 346334 48333 79349687
Hypocalcaemia 113.62 10.08 474 345894 49450 79348570
Fatigue 113.03 10.08 3126 343242 926601 78471419
Febrile neutropenia 113.01 10.08 567 345801 230432 79167588
Glomerular filtration rate decreased 112.97 10.08 282 346086 22420 79375600
Knee arthroplasty 110.47 10.08 26 346342 43222 79354798
Product use in unapproved indication 106.34 10.08 644 345724 249715 79148305
Sleep terror 105.71 10.08 113 346255 4345 79393675
Unevaluable event 105.12 10.08 55 346313 55530 79342490
Vertigo 105.08 10.08 584 345784 68498 79329522
Gastrointestinal haemorrhage 104.64 10.08 1041 345327 146678 79251342
Metabolic acidosis 104.54 10.08 665 345703 81864 79316156
Hemiparesis 103.98 10.08 353 346015 33380 79364640
Pregnancy 102.66 10.08 3 346365 26848 79371172
Exercise tolerance decreased 99.47 10.08 157 346211 8914 79389106
Epistaxis 98.88 10.08 825 345543 110690 79287330
Blister 97.89 10.08 235 346133 119241 79278779
Congestive cardiomyopathy 97.61 10.08 180 346188 11600 79386420
Bronchial secretion retention 97.27 10.08 104 346264 4000 79394020
Cholestasis 96.95 10.08 466 345902 51643 79346377
Cardiac failure acute 96.16 10.08 237 346131 18692 79379328
Tachycardia 95.83 10.08 1187 345181 176581 79221439
Urticaria 95.55 10.08 446 345922 184755 79213265
Orthopnoea 95.15 10.08 163 346205 9910 79388110
Injection site swelling 94.66 10.08 43 346325 47089 79350931
Ill-defined disorder 94.42 10.08 88 346280 65787 79332233
Hip arthroplasty 94.34 10.08 20 346348 35736 79362284
Immunisation 94.26 10.08 77 346291 2090 79395930
Tricuspid valve incompetence 94.06 10.08 241 346127 19471 79378549
Carotid artery occlusion 93.21 10.08 139 346229 7508 79390512
Diastolic dysfunction 93.13 10.08 168 346200 10643 79387377
Blood cholesterol increased 92.98 10.08 137 346231 83583 79314437
Ventricular arrhythmia 91.46 10.08 149 346219 8691 79389329
Urogenital haemorrhage 90.15 10.08 55 346313 922 79397098
Depression 89.27 10.08 563 345805 216227 79181793
Dizziness 89.24 10.08 2952 343416 523489 78874531
Joint range of motion decreased 89.08 10.08 18 346350 33264 79364756
Pain in extremity 89.00 10.08 1084 345284 363454 79034566
Ventricular enlargement 88.20 10.08 49 346319 683 79397337
Bundle branch block left 88.05 10.08 170 346198 11343 79386677
Eosinophilia 87.63 10.08 410 345958 44935 79353085
Blood creatinine increased 86.01 10.08 1041 345327 154016 79244004
Respiratory arrest 85.93 10.08 74 346294 57476 79340544
Therapy cessation 85.83 10.08 28 346340 37534 79360486
Stress 85.78 10.08 133 346235 79479 79318541
Impaired healing 85.61 10.08 156 346212 87499 79310521
Weight increased 85.07 10.08 782 345586 276604 79121416
Illness 85.07 10.08 48 346320 46463 79351557
Tension headache 84.94 10.08 129 346239 7082 79390938
Flushing 84.52 10.08 159 346209 88109 79309911
Platelet count decreased 83.02 10.08 500 345868 194164 79203856
Wound 82.69 10.08 245 346123 115934 79282086
Loss of consciousness 82.32 10.08 1102 345266 166841 79231179
Pericarditis 82.28 10.08 209 346159 104027 79293993
Sinus node dysfunction 81.30 10.08 131 346237 7570 79390450
Right atrial hypertrophy 80.50 10.08 47 346321 724 79397296
Blood pressure systolic decreased 79.20 10.08 159 346209 10917 79387103
Gastrointestinal disorder 78.39 10.08 270 346098 121935 79276085
Lip swelling 78.39 10.08 369 345999 40542 79357478
Mobility decreased 78.32 10.08 270 346098 121905 79276115
Hypovolaemic shock 78.14 10.08 168 346200 12108 79385912
Hemiplegia 77.97 10.08 189 346179 14750 79383270
Erysipelas 77.88 10.08 156 346212 10694 79387326
Inferior vena cava dilatation 77.74 10.08 48 346320 823 79397197
Chronic kidney disease 77.65 10.08 523 345845 65631 79332389
Cardioactive drug level increased 77.53 10.08 88 346280 3621 79394399
Hypoaesthesia 77.36 10.08 459 345909 178893 79219127
Full blood count decreased 77.23 10.08 12 346356 26807 79371213
Pemphigoid 77.00 10.08 191 346177 15124 79382896
Cerebral haematoma 76.98 10.08 130 346238 7812 79390208
Injury 76.51 10.08 137 346231 77359 79320661
Pallor 75.98 10.08 423 345945 49639 79348381
Injection site bruising 75.44 10.08 42 346326 40960 79357060
Vital capacity decreased 73.73 10.08 62 346306 1754 79396266
Abortion spontaneous 72.91 10.08 19 346349 29488 79368532
Vascular purpura 72.53 10.08 78 346290 3020 79395000
Contraindicated product administered 72.35 10.08 395 345973 157143 79240877
Venous pressure jugular increased 72.12 10.08 54 346314 1286 79396734
Nausea 72.06 10.08 3412 342956 953784 78444236
Device issue 71.85 10.08 15 346353 27093 79370927
Aortic valve stenosis 71.47 10.08 101 346267 5193 79392827
Respiratory tract haemorrhage 71.47 10.08 61 346307 1762 79396258
Chest pain 71.43 10.08 1667 344701 280637 79117383
Seizure 71.40 10.08 503 345865 188331 79209689
Hallucination, visual 70.03 10.08 305 346063 32424 79365596
Ischaemic cardiomyopathy 69.40 10.08 122 346246 7573 79390447
Nasal congestion 68.89 10.08 143 346225 76409 79321611
Bursitis 68.47 10.08 35 346333 35809 79362211
Bloody discharge 67.83 10.08 61 346307 1892 79396128
Drug dependence 67.76 10.08 47 346321 40722 79357298
Bronchitis 67.73 10.08 314 346054 130330 79267690
Neutrophil count decreased 67.69 10.08 197 346171 93762 79304258
Osteoarthritis 67.41 10.08 177 346191 87132 79310888
Night sweats 67.39 10.08 76 346292 52019 79346001
Adverse event 67.38 10.08 98 346270 60116 79337904
Microcytic anaemia 67.36 10.08 98 346270 5176 79392844
Grip strength decreased 67.20 10.08 8 346360 21861 79376159
Accidental exposure to product 67.04 10.08 26 346342 31296 79366724
Anosmia 66.91 10.08 130 346238 8714 79389306
Ventricular extrasystoles 66.82 10.08 213 346155 19491 79378529
Hyperthyroidism 66.34 10.08 230 346138 21979 79376041
Back pain 64.54 10.08 931 345437 303249 79094771
Abnormal loss of weight 64.45 10.08 124 346244 8252 79389768
Vascular stent thrombosis 64.31 10.08 80 346288 3630 79394390
Myelosuppression 63.67 10.08 49 346319 40247 79357773
Disorientation 63.62 10.08 479 345889 62297 79335723
Asthma 63.54 10.08 336 346032 134759 79263261
Faeces discoloured 63.52 10.08 273 346095 28854 79369166
Inappropriate antidiuretic hormone secretion 63.16 10.08 254 346114 26059 79371961
Asthenia 62.93 10.08 2770 343598 508919 78889101
Haemarthrosis 62.91 10.08 100 346268 5712 79392308
Hallucination 62.51 10.08 608 345760 85137 79312883
Ear infection 62.30 10.08 36 346332 34396 79363624
Therapy interrupted 62.30 10.08 29 346339 31312 79366708
Injection site rash 62.11 10.08 4 346364 17950 79380070
Pulmonary function test abnormal 61.87 10.08 83 346285 4061 79393959
Blood creatine phosphokinase increased 60.74 10.08 493 345875 65597 79332423
Embolic stroke 60.39 10.08 116 346252 7710 79390310
Minimum inhibitory concentration 58.96 10.08 24 346344 156 79397864
Atrial thrombosis 58.88 10.08 76 346292 3580 79394440
Acute pulmonary oedema 58.84 10.08 165 346203 14065 79383955
Drug resistance 58.62 10.08 58 346310 42155 79355865
Urinary retention 58.46 10.08 434 345934 56196 79341824
Fungal infection 58.39 10.08 57 346311 41691 79356329
Therapy non-responder 57.81 10.08 206 346162 92099 79305921
Therapeutic product effect incomplete 57.69 10.08 369 345999 141276 79256744
Left atrial enlargement 57.12 10.08 45 346323 1158 79396862
Pneumonia 56.87 10.08 2318 344050 657928 78740092
Transient ischaemic attack 56.78 10.08 408 345960 52287 79345733
Neck pain 56.63 10.08 155 346213 75262 79322758
Toxic skin eruption 56.58 10.08 219 346149 22074 79375946
Product quality issue 56.58 10.08 39 346329 33901 79364119
Multimorbidity 56.10 10.08 48 346320 1391 79396629
Therapeutic response decreased 55.94 10.08 130 346238 66723 79331297
Agranulocytosis 55.87 10.08 361 346007 44669 79353351
Myocardial ischaemia 55.50 10.08 239 346129 25280 79372740
Hypoxia 55.39 10.08 245 346123 102998 79295022
Antimicrobial susceptibility test resistant 55.20 10.08 29 346339 359 79397661
Hepatocellular injury 55.10 10.08 375 345993 47218 79350802
Herpes zoster 54.85 10.08 213 346155 92870 79305150
Chills 54.77 10.08 439 345929 159795 79238225
Nephrolithiasis 54.61 10.08 92 346276 53199 79344821
Brain natriuretic peptide increased 54.60 10.08 120 346248 8780 79389240
Oesophageal perforation 54.43 10.08 49 346319 1522 79396498
No adverse event 54.11 10.08 49 346319 37143 79360877
Atrial enlargement 53.85 10.08 41 346327 1002 79397018
Haemorrhage intracranial 53.69 10.08 241 346127 25952 79372068
Bone erosion 53.69 10.08 7 346361 17840 79380180
Lower limb fracture 53.58 10.08 17 346351 23198 79374822
Gravitational oedema 53.40 10.08 52 346316 1787 79396233
Reversible airways obstruction 53.09 10.08 56 346312 2120 79395900
Drug ineffective for unapproved indication 52.93 10.08 88 346280 51150 79346870
Atrioventricular block first degree 52.80 10.08 146 346222 12345 79385675
Right ventricular hypertrophy 52.70 10.08 49 346319 1588 79396432
Hyponatraemic syndrome 52.47 10.08 36 346332 744 79397276
Systolic dysfunction 52.12 10.08 73 346295 3722 79394298
Influenza 52.08 10.08 339 346029 129267 79268753
Renin increased 51.94 10.08 24 346344 220 79397800
Degenerative mitral valve disease 51.93 10.08 26 346342 289 79397731
Haemorrhagic stroke 51.62 10.08 134 346234 10912 79387108
Therapeutic drug monitoring analysis not performed 51.15 10.08 52 346316 1884 79396136
Left ventricular failure 50.84 10.08 122 346246 9459 79388561
Occult blood 50.56 10.08 49 346319 1674 79396346
Live birth 50.45 10.08 10 346358 18734 79379286
Oropharyngeal pain 50.30 10.08 274 346094 109079 79288941
Vasculitis 49.99 10.08 229 346139 24873 79373147
Electrocardiogram Q wave abnormal 49.43 10.08 32 346336 598 79397422
Bronchial wall thickening 49.10 10.08 59 346309 2582 79395438
Multiple sclerosis relapse 48.93 10.08 79 346289 46454 79351566
Hepatojugular reflux 48.61 10.08 32 346336 616 79397404
Disability 48.53 10.08 8 346360 17112 79380908
Sinoatrial block 48.51 10.08 43 346325 1308 79396712
Sedation 48.35 10.08 95 346273 51800 79346220
Intraventricular haemorrhage 47.37 10.08 80 346288 4807 79393213
Malignant mediastinal neoplasm 46.80 10.08 43 346325 1372 79396648
Duodenal ulcer haemorrhage 46.71 10.08 99 346269 7064 79390956
Skin haemorrhage 46.70 10.08 136 346232 11845 79386175
Blood pressure decreased 46.39 10.08 647 345721 98819 79299201
Haematoma muscle 46.31 10.08 57 346311 2558 79395462
Neurologic neglect syndrome 46.14 10.08 60 346308 2847 79395173
Gait inability 45.82 10.08 119 346249 58798 79339222
Respiratory depression 45.72 10.08 32 346336 27598 79370422
Hypothermia 45.66 10.08 208 346160 22538 79375482
ECG signs of myocardial ischaemia 45.47 10.08 25 346343 341 79397679
Thrombosis 45.46 10.08 199 346169 83901 79314119
Benign prostatic hyperplasia 45.44 10.08 132 346236 11480 79386540
Intentional product use issue 45.23 10.08 432 345936 151680 79246340
Subcutaneous haematoma 45.15 10.08 58 346310 2719 79395301
Road traffic accident 45.09 10.08 75 346293 43589 79354431
Normocytic anaemia 45.01 10.08 72 346296 4135 79393885
Sinus rhythm 44.90 10.08 34 346334 824 79397196
Emotional distress 44.77 10.08 65 346303 39904 79358116
Left ventricular hypertrophy 44.55 10.08 128 346240 11063 79386957
Left ventricular enlargement 44.52 10.08 32 346336 714 79397306
Mitral valve thickening 44.51 10.08 26 346342 401 79397619
Monoparesis 44.49 10.08 65 346303 3446 79394574
Peripheral swelling 44.47 10.08 864 345504 268753 79129267
Arthritis 44.39 10.08 304 346064 114576 79283444
Troponin T increased 44.34 10.08 65 346303 3457 79394563
Vasoplegia syndrome 44.27 10.08 66 346302 3564 79394456
Cardiac aneurysm 44.23 10.08 43 346325 1475 79396545
Atrioventricular block second degree 44.19 10.08 98 346270 7214 79390806
Irritability 44.06 10.08 69 346299 41075 79356945
Injection site haemorrhage 43.89 10.08 34 346334 27836 79370184
Multiple sclerosis 43.70 10.08 21 346347 22261 79375759
Small intestinal obstruction 43.29 10.08 33 346335 27239 79370781
Joint stiffness 43.23 10.08 69 346299 40761 79357259
Migraine 43.17 10.08 214 346154 87279 79310741
Tinnitus 43.09 10.08 335 346033 43998 79354022
Osteoporosis 43.08 10.08 108 346260 54004 79344016
Product administration error 43.06 10.08 261 346107 31585 79366435
Lower gastrointestinal haemorrhage 43.06 10.08 161 346207 15964 79382056
Cellulitis 42.94 10.08 287 346081 108773 79289247
Insomnia 42.48 10.08 779 345589 244391 79153629
Pathogen resistance 42.26 10.08 6 346362 14336 79383684
Gamma-glutamyltransferase increased 41.96 10.08 392 345976 54288 79343732
Retinal artery occlusion 41.77 10.08 61 346307 3233 79394787
Muscle spasms 41.66 10.08 522 345846 174208 79223812
Contusion 41.53 10.08 429 345939 148347 79249673
Drug dispensed to wrong patient 41.49 10.08 30 346338 676 79397344
Colitis erosive 41.38 10.08 18 346350 141 79397879
Polyneuropathy 41.37 10.08 211 346157 23940 79374080
Loss of personal independence in daily activities 41.37 10.08 268 346100 102312 79295708
Pyrexia 41.18 10.08 2471 343897 676238 78721782
Nocturia 41.14 10.08 142 346226 13539 79384481
Surgery 41.09 10.08 49 346319 32717 79365303
Abdominal wall haematoma 41.05 10.08 75 346293 4798 79393222
Foot deformity 41.02 10.08 27 346341 24047 79373973
Polyuria 41.01 10.08 151 346217 14863 79383157
Tachypnoea 40.98 10.08 259 346109 31804 79366216
Aortic valve incompetence 40.88 10.08 112 346256 9418 79388602
Device difficult to use 40.88 10.08 5 346363 13380 79384640
Viral infection 40.72 10.08 78 346290 42938 79355082
Angioedema 40.62 10.08 507 345861 75528 79322492
Facial pain 40.51 10.08 132 346236 12218 79385802
Graft versus host disease 40.48 10.08 8 346360 15018 79383002
Peripheral arterial occlusive disease 40.48 10.08 102 346266 8156 79389864
Cardiovascular insufficiency 40.43 10.08 57 346311 2924 79395096
Oliguria 40.40 10.08 159 346209 16150 79381870
Intestinal haemorrhage 39.83 10.08 87 346281 6339 79391681
Cardiac murmur 39.79 10.08 155 346213 15669 79382351
Spontaneous haemorrhage 39.74 10.08 31 346337 786 79397234
Neoplasm progression 39.72 10.08 105 346263 51577 79346443
Duodenitis 39.67 10.08 99 346269 7868 79390152
Exostosis 39.53 10.08 12 346356 16846 79381174
Carotid artery thrombosis 39.38 10.08 57 346311 2996 79395024
Pleural effusion 39.26 10.08 866 345502 144396 79253624
Ventricular fibrillation 39.03 10.08 255 346113 31671 79366349
Shock 39.02 10.08 323 346045 43225 79354795
Drug reaction with eosinophilia and systemic symptoms 39.01 10.08 439 345929 63805 79334215
Medication error 38.97 10.08 463 345905 68179 79329841
Subdural haemorrhage 38.55 10.08 82 346286 5866 79392154
Ear pain 38.26 10.08 52 346316 32817 79365203
Sciatica 38.23 10.08 53 346315 33169 79364851
Lyme disease 38.15 10.08 59 346309 3291 79394729
Therapy partial responder 37.97 10.08 14 346354 17383 79380637
Dysarthria 37.90 10.08 455 345913 67167 79330853
Cardiac tamponade 37.81 10.08 107 346261 9169 79388851
Feeling abnormal 37.80 10.08 476 345892 158723 79239297
Pericardial haemorrhage 37.64 10.08 69 346299 4426 79393594
Nodule 37.56 10.08 27 346341 22967 79375053
Disease recurrence 37.52 10.08 85 346283 44024 79353996
Lupus vasculitis 37.45 10.08 26 346342 548 79397472
Gastroenteritis viral 36.98 10.08 32 346336 24799 79373221
Thalamus haemorrhage 36.78 10.08 42 346326 1740 79396280
Extrasystoles 36.74 10.08 92 346276 7327 79390693
Blood loss anaemia 36.71 10.08 149 346219 15349 79382671
Complication associated with device 36.66 10.08 15 346353 17481 79380539
Pulmonary vascular disorder 36.52 10.08 33 346335 1030 79396990
Drug withdrawal syndrome 36.44 10.08 59 346309 34659 79363361
Paresis 36.43 10.08 66 346302 4195 79393825
Cardiovascular disorder 36.31 10.08 165 346203 17860 79380160
Potentiating drug interaction 36.21 10.08 102 346266 8717 79389303
Dermatitis bullous 36.20 10.08 140 346228 14105 79383915
Eye pruritus 36.14 10.08 181 346187 20389 79377631
Acute cutaneous lupus erythematosus 36.00 10.08 22 346346 370 79397650
Acne 35.90 10.08 39 346329 27151 79370869
Food allergy 35.76 10.08 3 346365 10821 79387199
Psoriasis 35.64 10.08 235 346133 89352 79308668
Tooth disorder 35.33 10.08 37 346331 26196 79371824
Procedural pain 35.30 10.08 29 346339 23055 79374965
Crying 35.17 10.08 29 346339 23014 79375006
Lower respiratory tract infection 35.09 10.08 375 345993 128845 79269175
Red blood cell sedimentation rate abnormal 35.06 10.08 24 346344 20939 79377081
Psychotic disorder 35.05 10.08 80 346288 41322 79356698
Needle fatigue 34.99 10.08 30 346338 872 79397148
Drug level increased 34.94 10.08 293 346075 39358 79358662
Bacterial infection 34.90 10.08 51 346317 31229 79366791
Condition aggravated 34.85 10.08 1800 344568 499324 78898696
Hypoglycaemic coma 34.84 10.08 69 346299 4691 79393329
Strangury 34.84 10.08 17 346351 178 79397842
Bone disorder 34.56 10.08 20 346348 19093 79378927
Oral herpes 34.48 10.08 41 346327 27413 79370607
Liver function test abnormal 34.48 10.08 430 345938 64045 79333975
Immune thrombocytopenia 34.40 10.08 161 346207 17644 79380376
Cerebral ischaemia 34.36 10.08 117 346251 11078 79386942
Pain of skin 34.23 10.08 140 346228 14473 79383547
Anhedonia 34.22 10.08 11 346357 14887 79383133
Emotional disorder 34.17 10.08 10 346358 14377 79383643
Cardiomyopathy 34.07 10.08 228 346140 28546 79369474
Electrocardiogram PR prolongation 33.84 10.08 38 346330 1545 79396475
Anaemia macrocytic 33.81 10.08 75 346293 5522 79392498
Myocardial infarction 33.54 10.08 1042 345326 183087 79214933
Heart sounds abnormal 33.41 10.08 36 346332 1397 79396623
Tenderness 33.39 10.08 32 346336 23610 79374410
Coma scale abnormal 33.34 10.08 98 346270 8580 79389440
Device leakage 33.29 10.08 4 346364 10852 79387168
Hypersensitivity vasculitis 33.24 10.08 85 346283 6858 79391162
Muscle haemorrhage 33.19 10.08 80 346288 6220 79391800
Purpura 33.03 10.08 170 346198 19357 79378663
Adverse drug reaction 32.98 10.08 162 346206 66230 79331790
Cerebral ventricular rupture 32.77 10.08 22 346346 438 79397582
Haemothorax 32.63 10.08 73 346295 5405 79392615
Heart rate decreased 32.62 10.08 457 345911 69859 79328161
Joint injury 32.19 10.08 54 346314 31281 79366739
Injection site warmth 32.17 10.08 12 346356 14795 79383225
Cytomegalovirus viraemia 32.17 10.08 8 346360 12813 79385207
Drug monitoring procedure not performed 32.04 10.08 30 346338 981 79397039
Myositis 31.82 10.08 166 346202 19002 79379018
Head injury 31.80 10.08 274 346094 37095 79360925
Infective exacerbation of chronic obstructive airways disease 31.66 10.08 49 346319 2735 79395285
Inflammation 31.50 10.08 258 346110 93495 79304525
Aphasia 31.46 10.08 326 346042 46406 79351614
Anxiety 31.42 10.08 830 345538 247682 79150338
Plasma cell myeloma 31.29 10.08 122 346246 53137 79344883
Immunodeficiency 31.28 10.08 29 346339 21739 79376281
Cerebellar haemorrhage 31.27 10.08 50 346318 2870 79395150
Gastritis erosive 31.24 10.08 111 346257 10736 79387284
Gallbladder disorder 31.22 10.08 23 346345 19317 79378703
Post transplant lymphoproliferative disorder 31.10 10.08 6 346362 11458 79386562
Aortic stenosis 31.08 10.08 87 346281 7408 79390612
Gout 31.06 10.08 199 346169 24550 79373470
Hypochloraemia 31.06 10.08 46 346322 2469 79395551
Periorbital haematoma 31.06 10.08 29 346339 945 79397075
Inflammatory marker increased 31.02 10.08 110 346258 10630 79387390
Product dispensing error 31.01 10.08 127 346241 13136 79384884
Thrombocytopenia 30.99 10.08 1429 344939 263830 79134190
Foot fracture 30.75 10.08 30 346338 21951 79376069
Gastrooesophageal reflux disease 30.58 10.08 297 346071 103949 79294071
Carotid arteriosclerosis 30.56 10.08 47 346321 2609 79395411
Breath sounds abnormal 30.49 10.08 144 346224 15840 79382180
Product complaint 30.41 10.08 10 346358 13339 79384681
Bone density decreased 30.40 10.08 10 346358 13337 79384683
Obstruction 30.39 10.08 64 346304 4546 79393474
Hypocoagulable state 30.35 10.08 42 346326 2117 79395903
Diabetic metabolic decompensation 30.27 10.08 53 346315 3279 79394741
International normalised ratio abnormal 30.13 10.08 73 346295 5695 79392325
Rhinitis allergic 30.12 10.08 8 346360 12261 79385759
Helicobacter test positive 30.12 10.08 33 346335 1305 79396715
Hyperuricaemia 30.02 10.08 116 346252 11683 79386337
Gait spastic 29.55 10.08 31 346337 1166 79396854
Stenosis 29.48 10.08 44 346324 2378 79395642
Weight decreased 29.43 10.08 1252 345116 353946 79044074
Optic ischaemic neuropathy 29.41 10.08 49 346319 2912 79395108
Blood thyroid stimulating hormone increased 29.39 10.08 101 346267 9607 79388413
Myopathy 29.39 10.08 171 346197 20392 79377628
Hypochromic anaemia 29.32 10.08 47 346321 2704 79395316
Atelectasis 29.23 10.08 60 346308 32197 79365823
Cardiac septal hypertrophy 29.17 10.08 17 346351 261 79397759
Disturbance in attention 28.99 10.08 343 346025 50458 79347562
Neoplasm malignant 28.97 10.08 59 346309 31751 79366269
Therapeutic response delayed 28.95 10.08 30 346338 1112 79396908
Tongue oedema 28.91 10.08 82 346286 7035 79390985
Sedation complication 28.90 10.08 16 346352 15653 79382367
Femoral hernia incarcerated 28.65 10.08 26 346342 816 79397204
Poisoning deliberate 28.50 10.08 159 346209 18669 79379351
Malaise 28.47 10.08 2484 343884 487385 78910635
Paraesthesia 28.45 10.08 567 345801 175756 79222264
Spinal cord haemorrhage 28.40 10.08 22 346346 552 79397468
Infusion site pain 28.36 10.08 13 346355 14163 79383857
Extremity necrosis 28.36 10.08 50 346318 3111 79394909
Candida infection 28.34 10.08 79 346289 38135 79359885
Rash maculo-papular 28.29 10.08 370 345998 55708 79342312
Tendon rupture 28.26 10.08 116 346252 12010 79386010
Hepatic vein dilatation 28.25 10.08 16 346352 232 79397788
Bone marrow failure 28.19 10.08 120 346248 50987 79347033
Hip fracture 28.06 10.08 57 346311 30704 79367316
Angina unstable 28.04 10.08 144 346224 16383 79381637
Inappropriate schedule of product administration 27.95 10.08 410 345958 133218 79264802
Hyperglycaemia 27.90 10.08 445 345923 69890 79328130
Sputum culture positive 27.90 10.08 55 346313 3726 79394294
Pancreatitis acute 27.90 10.08 334 346034 49270 79348750
Dyspnoea paroxysmal nocturnal 27.87 10.08 41 346327 2187 79395833
Urinary hesitation 27.87 10.08 59 346309 4207 79393813
Adrenal cyst 27.85 10.08 14 346354 157 79397863
Ejection fraction abnormal 27.82 10.08 43 346325 2397 79395623
Sleep disorder 27.78 10.08 238 346130 85439 79312581
Subacute cutaneous lupus erythematosus 27.74 10.08 53 346315 3508 79394512
Soft tissue mass 27.67 10.08 31 346337 1257 79396763
Back disorder 27.59 10.08 8 346360 11570 79386450
Prerenal failure 27.54 10.08 54 346314 3644 79394376
Craniocerebral injury 27.40 10.08 66 346302 5130 79392890
Throat irritation 27.25 10.08 89 346279 40857 79357163
Myoglobin blood increased 27.18 10.08 49 346319 3102 79394918
Sight disability 27.16 10.08 13 346355 130 79397890
Sinus arrest 27.11 10.08 53 346315 3569 79394451
Waist circumference increased 27.03 10.08 35 346333 1654 79396366
Blood glucose abnormal 26.98 10.08 104 346264 10462 79387558
Lipids abnormal 26.87 10.08 22 346346 599 79397421
Dystonia 26.83 10.08 32 346336 21367 79376653
Brain stem infarction 26.75 10.08 38 346330 1963 79396057
Epileptic encephalopathy 26.72 10.08 20 346348 476 79397544
Transplant rejection 26.65 10.08 27 346341 19410 79378610
Vascular stent stenosis 26.58 10.08 33 346335 1494 79396526
Bundle branch block right 26.52 10.08 108 346260 11143 79386877
Blood calcium decreased 26.51 10.08 62 346306 31757 79366263
Language disorder 26.49 10.08 49 346319 3165 79394855
Ocular myasthenia 26.36 10.08 18 346350 369 79397651
Aortic arteriosclerosis 26.32 10.08 92 346276 8826 79389194
Cholestatic liver injury 26.31 10.08 63 346305 4878 79393142
Hypokinesia 26.27 10.08 157 346211 18903 79379117
Epstein-Barr virus infection 26.18 10.08 15 346353 14401 79383619
Dry eye 26.18 10.08 78 346290 36853 79361167
Scar 25.95 10.08 17 346351 15179 79382841
Cushingoid 25.91 10.08 5 346363 9547 79388473
Aspergillus infection 25.84 10.08 27 346341 19134 79378886
Hepatotoxicity 25.68 10.08 125 346243 51227 79346793
Anaphylactic reaction 25.67 10.08 236 346132 83507 79314513
Dermatitis exfoliative 25.56 10.08 104 346264 10725 79387295
Carotid artery stenosis 25.55 10.08 90 346278 8668 79389352
Peripheral artery stenosis 25.55 10.08 30 346338 1281 79396739
Skin pressure mark 25.42 10.08 11 346357 85 79397935
Pancreatic steatosis 25.36 10.08 28 346340 1117 79396903
Deprescribing error 25.34 10.08 8 346360 21 79397999
Basilar artery occlusion 25.34 10.08 14 346354 193 79397827
Tooth abscess 25.24 10.08 20 346348 16190 79381830
BK virus infection 25.21 10.08 4 346364 8800 79389220
Androgenetic alopecia 25.17 10.08 13 346355 155 79397865
Erosive duodenitis 25.12 10.08 38 346330 2079 79395941
Coeliac disease 25.00 10.08 9 346359 11342 79386678
Orthostatic intolerance 24.93 10.08 36 346332 1888 79396132
Arterial haemorrhage 24.93 10.08 42 346326 2519 79395501
Vertebrobasilar insufficiency 24.90 10.08 16 346352 295 79397725
Supine hypertension 24.88 10.08 18 346350 406 79397614
Staphylococcal infection 24.69 10.08 150 346218 58145 79339875
Pulmonary thrombosis 24.60 10.08 11 346357 12160 79385860
Lichen planopilaris 24.56 10.08 9 346359 42 79397978
Brain stem haemorrhage 24.56 10.08 33 346335 1617 79396403
Diverticulum intestinal haemorrhagic 24.51 10.08 54 346314 3957 79394063
Retroperitoneal haematoma 24.49 10.08 64 346304 5233 79392787
Chronic sinusitis 24.46 10.08 13 346355 13013 79385007
Temperature intolerance 24.46 10.08 6 346362 9699 79388321
Intestinal transit time abnormal 24.44 10.08 10 346358 66 79397954
Brain contusion 24.43 10.08 30 346338 1343 79396677
Myocarditis 24.42 10.08 170 346198 21563 79376457
Jugular vein distension 24.37 10.08 31 346337 1439 79396581
Faeces pale 24.34 10.08 45 346323 2905 79395115
Immune reconstitution inflammatory syndrome 24.30 10.08 15 346353 13826 79384194
Rhinovirus infection 24.21 10.08 3 346365 7950 79390070
Aortic dissection 24.16 10.08 55 346313 4120 79393900
Adjustment disorder with depressed mood 24.14 10.08 5 346363 9081 79388939
Appendicitis 24.10 10.08 33 346335 20761 79377259
Red blood cell sedimentation rate increased 24.05 10.08 110 346258 45832 79352188
Respiratory tract infection 24.04 10.08 320 346048 48369 79349651
Hepatitis acute 24.03 10.08 132 346236 15410 79382610
Duodenal ulcer 23.97 10.08 137 346231 16232 79381788
Incorrect route of product administration 23.88 10.08 75 346293 34854 79363166
Lymphatic fistula 23.87 10.08 23 346345 780 79397240
Feeling jittery 23.84 10.08 13 346355 12828 79385192
Therapeutic response unexpected 23.78 10.08 31 346337 19915 79378105
Diplopia 23.74 10.08 236 346132 33230 79364790
Obstructive pancreatitis 23.69 10.08 24 346344 866 79397154
Troponin increased 23.66 10.08 154 346214 19101 79378919
Erectile dysfunction 23.66 10.08 126 346242 14538 79383482
Premature delivery 23.60 10.08 41 346327 23426 79374594
Hypersomnia 23.52 10.08 40 346328 23046 79374974
Chronic coronary syndrome 23.51 10.08 11 346357 104 79397916
Pharyngitis 23.51 10.08 38 346330 22337 79375683
Bacteraemia 23.50 10.08 69 346299 32755 79365265
Fluid retention 23.50 10.08 192 346176 69617 79328403
Laryngitis 23.49 10.08 21 346347 16018 79382002
Blood lactic acid 23.46 10.08 18 346350 445 79397575
Adrenal insufficiency 23.34 10.08 56 346312 28431 79369589
Lipid metabolism disorder 23.22 10.08 16 346352 333 79397687
Mania 23.22 10.08 27 346341 18233 79379787
Ventricular hyperkinesia 23.00 10.08 15 346353 284 79397736
Tachycardia induced cardiomyopathy 22.98 10.08 13 346355 188 79397832
Cytomegalovirus infection 22.98 10.08 101 346267 42543 79355477
Ammonia increased 22.96 10.08 3 346365 7632 79390388
Posterior reversible encephalopathy syndrome 22.88 10.08 50 346318 26231 79371789
Sudden hearing loss 22.87 10.08 35 346333 1934 79396086
Cytokine release syndrome 22.76 10.08 80 346288 35918 79362102
Pain in jaw 22.70 10.08 113 346255 46038 79351982
Intracranial haematoma 22.59 10.08 24 346344 916 79397104
Peripheral ischaemia 22.46 10.08 91 346277 9366 79388654
Clostridium difficile infection 22.46 10.08 102 346266 42583 79355437
Injection site mass 22.43 10.08 33 346335 20151 79377869
Pneumonia viral 22.43 10.08 6 346362 9152 79388868
Vascular pseudoaneurysm 22.30 10.08 48 346320 3462 79394558
Seasonal allergy 22.25 10.08 23 346345 16383 79381637
Cerebrospinal fluid circulation disorder 22.22 10.08 5 346363 0 79398020
Skin weeping 22.16 10.08 25 346343 1022 79396998
Dermatitis atopic 22.10 10.08 8 346360 10048 79387972
Urine output decreased 22.06 10.08 144 346224 17878 79380142
Relapsing-remitting multiple sclerosis 22.03 10.08 30 346338 1489 79396531
Spontaneous haematoma 22.03 10.08 29 346339 1393 79396627
Drop attacks 22.00 10.08 25 346343 1030 79396990
Urosepsis 21.88 10.08 193 346175 26302 79371718
Eye irritation 21.84 10.08 35 346333 20646 79377374
Spinal operation 21.78 10.08 4 346364 7913 79390107
Haemorrhagic diathesis 21.76 10.08 67 346301 6017 79392003
Polycythaemia 21.63 10.08 37 346331 2247 79395773
Procalcitonin abnormal 21.62 10.08 16 346352 374 79397646
Macular degeneration 21.62 10.08 11 346357 11285 79386735
Renal injury 21.56 10.08 25 346343 16902 79381118
Immune-mediated myositis 21.56 10.08 47 346321 3420 79394600
Peripheral embolism 21.52 10.08 34 346334 1932 79396088
Premature labour 21.51 10.08 5 346363 8385 79389635
Cold sweat 21.44 10.08 147 346221 18552 79379468
Haematocrit decreased 21.39 10.08 167 346201 61145 79336875
Embolic cerebral infarction 21.38 10.08 27 346341 1244 79396776
Basal ganglia haemorrhage 21.27 10.08 31 346337 1640 79396380
Tachycardia paroxysmal 21.23 10.08 16 346352 385 79397635
Faecaloma 21.20 10.08 103 346265 11461 79386559
Hypoparathyroidism 21.19 10.08 25 346343 1073 79396947
Nightmare 21.16 10.08 188 346180 25673 79372347
Ocular hyperaemia 21.15 10.08 58 346310 28148 79369872
Osteonecrosis 21.10 10.08 67 346301 31028 79366992
Platelet distribution width increased 21.09 10.08 11 346357 134 79397886
Musculoskeletal disorder 21.09 10.08 38 346330 21410 79376610
Iron deficiency 21.07 10.08 97 346271 10557 79387463
Onychomycosis 21.03 10.08 5 346363 8256 79389764
Rash papular 20.96 10.08 165 346203 21751 79376269
Memory impairment 20.94 10.08 350 346018 111384 79286636
Petechiae 20.88 10.08 157 346211 20408 79377612
Device use error 20.85 10.08 3 346365 7098 79390922
Acute graft versus host disease 20.85 10.08 9 346359 10158 79387862
Generalised tonic-clonic seizure 20.75 10.08 109 346259 43801 79354219
Vision blurred 20.74 10.08 329 346039 105569 79292451
Vascular encephalopathy 20.74 10.08 19 346349 604 79397416
Constipation 20.74 10.08 1011 345357 282039 79115981
Injection site extravasation 20.73 10.08 8 346360 9661 79388359
Breast cancer female 20.71 10.08 12 346356 11449 79386571
Blood test abnormal 20.63 10.08 28 346340 17682 79380338
Pre-eclampsia 20.62 10.08 3 346365 7038 79390982
Wrong technique in product usage process 20.61 10.08 213 346155 73662 79324358
Respiratory failure 20.61 10.08 613 345755 180298 79217722
Heart rate irregular 20.61 10.08 225 346143 32454 79365566
Diverticulum intestinal 20.60 10.08 83 346285 8522 79389498
Ultrasound uterus abnormal 20.57 10.08 7 346361 25 79397995
Eosinophil count increased 20.53 10.08 136 346232 16969 79381051
Coagulation time prolonged 20.51 10.08 38 346330 2457 79395563
General physical condition abnormal 20.50 10.08 69 346299 6494 79391526
Poisoning 20.46 10.08 50 346318 25222 79372798
Liver palpable 20.44 10.08 15 346353 346 79397674
Superinfection 20.42 10.08 57 346311 4845 79393175
Cerebellar haematoma 20.40 10.08 19 346349 617 79397403
Bradyphrenia 20.40 10.08 96 346272 10544 79387476
Traumatic intracranial haemorrhage 20.37 10.08 26 346342 1211 79396809
Glaucoma 20.35 10.08 34 346334 19727 79378293
Fracture 20.23 10.08 163 346205 21638 79376382
Anticoagulation drug level above therapeutic 20.19 10.08 47 346321 3573 79394447
Neuropathy, ataxia, retinitis pigmentosa syndrome 20.19 10.08 8 346360 48 79397972
Sudden death 20.18 10.08 167 346201 22344 79375676
Demyelination 20.14 10.08 5 346363 8018 79390002
Blood creatine increased 20.14 10.08 88 346280 9367 79388653
Suicidal ideation 20.13 10.08 223 346145 76117 79321903
Electrocardiogram ST segment elevation 20.11 10.08 81 346287 8316 79389704
Eczema 20.04 10.08 268 346100 40550 79357470
Muscle tightness 20.02 10.08 16 346352 12898 79385122
Serum procollagen type I N-terminal propeptide increased 19.96 10.08 7 346361 28 79397992
Thermohypoaesthesia 19.91 10.08 10 346358 112 79397908
Muscular weakness 19.87 10.08 871 345497 159858 79238162
Fear 19.83 10.08 41 346327 21945 79376075
Helicobacter gastritis 19.76 10.08 37 346331 2412 79395608
Mood swings 19.75 10.08 35 346333 19845 79378175
Supraventricular extrasystoles 19.70 10.08 71 346297 6916 79391104
Bleeding time prolonged 19.65 10.08 26 346342 1255 79396765
Chest wall haematoma 19.63 10.08 16 346352 433 79397587
Autoimmune disorder 19.62 10.08 26 346342 16586 79381434
Spinal fracture 19.60 10.08 30 346338 18024 79379996
Glycosylated haemoglobin increased 19.53 10.08 147 346221 19113 79378907
Hepatic cytolysis 19.52 10.08 192 346176 26959 79371061
Left ventricular dilatation 19.50 10.08 24 346344 1077 79396943
Body temperature increased 19.49 10.08 113 346255 44307 79353713
Eye infection 19.47 10.08 14 346354 11906 79386114
Pustule 19.43 10.08 33 346335 1992 79396028
Gastric ulcer 19.38 10.08 229 346139 33676 79364344
Femur fracture 19.37 10.08 94 346274 38558 79359462
Xyphoid retraction 19.27 10.08 11 346357 162 79397858
High density lipoprotein decreased 19.27 10.08 54 346314 4601 79393419
Walking aid user 19.25 10.08 10 346358 10138 79387882
Polymerase chain reaction 19.23 10.08 10 346358 121 79397899
N-terminal prohormone brain natriuretic peptide abnormal 19.23 10.08 13 346355 262 79397758
Sepsis 19.22 10.08 965 345403 268463 79129557
Anorectal discomfort 19.18 10.08 46 346322 3565 79394455
Periarthritis calcarea 19.16 10.08 9 346359 86 79397934
Transplant dysfunction 19.13 10.08 4 346364 7217 79390803
Cystitis haemorrhagic 19.00 10.08 8 346360 9164 79388856
Ketoacidosis 19.00 10.08 76 346292 7778 79390242
Blood glucose fluctuation 18.92 10.08 68 346300 6614 79391406
Caesarean section 18.85 10.08 16 346352 12519 79385501
Nicotine dependence 18.85 10.08 22 346346 933 79397087
Rotator cuff syndrome 18.85 10.08 20 346348 14075 79383945
Malignant neoplasm progression 18.84 10.08 448 345920 135542 79262478
Traumatic haematoma 18.83 10.08 33 346335 2043 79395977
Altered state of consciousness 18.81 10.08 281 346087 43541 79354479
Percutaneous coronary intervention 18.78 10.08 15 346353 394 79397626
Melanoderma 18.75 10.08 15 346353 395 79397625
Stress cardiomyopathy 18.74 10.08 97 346271 11069 79386951
Nodal arrhythmia 18.67 10.08 32 346336 1946 79396074
Post procedural complication 18.62 10.08 48 346320 23781 79374239
Incorrect dose administered 18.60 10.08 228 346140 76402 79321618
Cardioversion 18.58 10.08 33 346335 2065 79395955
Body height decreased 18.56 10.08 7 346361 8573 79389447
Ventricle rupture 18.55 10.08 9 346359 93 79397927
Pneumonia fungal 18.53 10.08 13 346355 11197 79386823
Tongue disorder 18.50 10.08 20 346348 13955 79384065
Prescribed overdose 18.49 10.08 93 346275 37790 79360230
Enthesopathy 18.48 10.08 14 346354 11594 79386426
Osteochondrosis 18.46 10.08 32 346336 1964 79396056
Psychomotor retardation 18.43 10.08 64 346304 6120 79391900
Histamine level increased 18.38 10.08 9 346359 95 79397925
Increased appetite 18.37 10.08 15 346353 11963 79386057
Gastric haemorrhage 18.27 10.08 120 346248 14930 79383090
Iron deficiency anaemia 18.19 10.08 181 346187 25491 79372529
Concomitant disease progression 18.19 10.08 44 346324 3429 79394591
Febrile infection 18.18 10.08 43 346325 3303 79394717
Spinal disorder 18.18 10.08 11 346357 10249 79387771
Device breakage 18.15 10.08 12 346356 10663 79387357
Angiocardiogram 18.14 10.08 12 346356 233 79397787
Hepatorenal failure 18.07 10.08 25 346343 1260 79396760
Thiopurine methyltransferase decreased 18.05 10.08 14 346354 352 79397668
Benign gastrointestinal neoplasm 18.02 10.08 10 346358 139 79397881
Ovarian cyst 18.02 10.08 17 346351 12638 79385382
Blood potassium decreased 18 10.08 123 346245 46389 79351631
Bifascicular block 17.95 10.08 14 346354 355 79397665
Pulmonary valve disease 17.90 10.08 13 346355 295 79397725
Physical examination abnormal 17.86 10.08 13 346355 296 79397724
Personality disorder 17.79 10.08 63 346305 6083 79391937
Defect conduction intraventricular 17.77 10.08 16 346352 497 79397523
Hepatitis cholestatic 17.77 10.08 112 346256 13740 79384280
Infective spondylitis 17.74 10.08 16 346352 498 79397522
Paranasal sinus haematoma 17.67 10.08 7 346361 42 79397978
Hemiataxia 17.67 10.08 7 346361 42 79397978
Back injury 17.66 10.08 12 346356 10511 79387509
Hysterectomy 17.63 10.08 3 346365 6269 79391751
Limb discomfort 17.58 10.08 78 346290 32772 79365248
Nasal polyps 17.57 10.08 5 346363 7322 79390698
Therapeutic response shortened 17.56 10.08 26 346342 15837 79382183
Drug dose omission by device 17.54 10.08 3 346365 6247 79391773
Synovial cyst 17.54 10.08 11 346357 10054 79387966
Skin dystrophy 17.54 10.08 8 346360 71 79397949
Heavy menstrual bleeding 17.52 10.08 21 346347 13990 79384030
Haemoptysis 17.46 10.08 341 346027 55658 79342362
Product dose omission in error 17.45 10.08 6 346362 7782 79390238
Dyslipidaemia 17.45 10.08 98 346270 11535 79386485
Atypical fibroxanthoma 17.45 10.08 11 346357 196 79397824
Pulmonary oedema 17.29 10.08 504 345864 87750 79310270
Electrocardiogram T wave inversion 17.25 10.08 57 346311 5315 79392705
Bicytopenia 17.24 10.08 52 346316 4618 79393402
Drug use disorder 17.20 10.08 8 346360 8643 79389377
Nephrogenic systemic fibrosis 17.19 10.08 3 346365 6157 79391863
Colorectal cancer 17.19 10.08 8 346360 8639 79389381
Mucosal haemorrhage 17.16 10.08 36 346332 2550 79395470
Adjustment disorder 17.15 10.08 47 346321 3953 79394067
Procollagen type I C-terminal propeptide increased 17.11 10.08 6 346362 24 79397996
Photophobia 17.10 10.08 40 346328 20488 79377532
Hot flush 17.10 10.08 154 346214 54723 79343297
Skull fracture 17.07 10.08 29 346339 1751 79396269
Paradoxical drug reaction 17.05 10.08 5 346363 7180 79390840
Osteomyelitis 17.02 10.08 79 346289 32786 79365234
Graft versus host disease in skin 16.86 10.08 3 346365 6070 79391950
Acquired haemophilia 16.85 10.08 30 346338 1881 79396139
Drug therapeutic incompatibility 16.80 10.08 10 346358 160 79397860
Burning sensation 16.79 10.08 168 346200 58464 79339556
Transaminases increased 16.79 10.08 317 346051 51426 79346594
Muscle twitching 16.78 10.08 173 346195 24591 79373429
Cytopenia 16.76 10.08 40 346328 20343 79377677
Pyroglutamic acidosis 16.76 10.08 22 346346 1054 79396966
Nerve injury 16.74 10.08 10 346358 9382 79388638
Procalcitonin increased 16.73 10.08 39 346329 2967 79395053
Parkinsonian rest tremor 16.65 10.08 12 346356 269 79397751
Polycystic liver disease 16.64 10.08 10 346358 163 79397857
Drug abuser 16.63 10.08 3 346365 6010 79392010
Obstructive airways disorder 16.47 10.08 209 346159 31250 79366770
Ocular icterus 16.46 10.08 57 346311 5443 79392577
Blood potassium increased 16.41 10.08 197 346171 29078 79368942
Activated partial thromboplastin time prolonged 16.40 10.08 112 346256 14116 79383904
Mood altered 16.34 10.08 33 346335 17814 79380206
Carpal tunnel syndrome 16.31 10.08 38 346330 19490 79378530
Bladder sphincter atony 16.29 10.08 9 346359 124 79397896
Laryngeal haematoma 16.22 10.08 10 346358 171 79397849
Obesity 16.15 10.08 88 346280 35037 79362983
Subarachnoid haematoma 16.13 10.08 12 346356 283 79397737
Withdrawal syndrome 16.10 10.08 61 346307 26793 79371227
Renal tubular acidosis 16.03 10.08 43 346325 3571 79394449
Deep vein thrombosis 16.03 10.08 401 345967 120518 79277502
Puncture site haematoma 16.02 10.08 10 346358 175 79397845
Ventricular asystole 16.02 10.08 12 346356 286 79397734
Acute generalised exanthematous pustulosis 16.01 10.08 129 346239 17125 79380895
Glomerular filtration rate abnormal 16.00 10.08 27 346341 1621 79396399
Prothrombin time shortened 15.96 10.08 40 346328 3188 79394832
Pericardial effusion 15.95 10.08 286 346082 45951 79352069
Product preparation error 15.78 10.08 3 346365 5790 79392230
Postrenal failure 15.77 10.08 17 346351 660 79397360
Arrhythmia supraventricular 15.77 10.08 31 346337 2096 79395924
Pelvic pain 15.74 10.08 21 346347 13360 79384660
Documented hypersensitivity to administered product 15.74 10.08 20 346348 927 79397093
Diabetes mellitus inadequate control 15.73 10.08 168 346200 24096 79373924
Nodal rhythm 15.66 10.08 39 346329 3096 79394924
Anticoagulation drug level increased 15.62 10.08 18 346350 753 79397267
Brain stem ischaemia 15.60 10.08 12 346356 298 79397722
Status epilepticus 15.59 10.08 56 346312 24985 79373035
Device failure 15.53 10.08 4 346364 6257 79391763
Blood urea increased 15.52 10.08 298 346070 48492 79349528
Left atrial dilatation 15.51 10.08 39 346329 3114 79394906
Subcapsular renal haematoma 15.51 10.08 18 346350 759 79397261
Cholecystectomy 15.51 10.08 11 346357 9421 79388599
Ventricular internal diameter abnormal 15.48 10.08 11 346357 241 79397779
Injection site induration 15.43 10.08 12 346356 9807 79388213
Cannabinoid hyperemesis syndrome 15.36 10.08 7 346361 62 79397958
Frequent bowel movements 15.30 10.08 71 346297 29468 79368552
Respiratory acidosis 15.27 10.08 92 346276 11108 79386912
Seroma 15.24 10.08 32 346336 2268 79395752
Inflammatory bowel disease 15.24 10.08 3 346365 5648 79392372
Thermal burn 15.23 10.08 6 346362 7154 79390866
Injection site discolouration 15.20 10.08 7 346361 7607 79390413
Eastern Cooperative Oncology Group performance status worsened 15.19 10.08 30 346338 2035 79395985
Mental disorder 15.19 10.08 77 346291 31225 79366795
Red blood cell count decreased 15.17 10.08 168 346200 57345 79340675
Hypertensive angiopathy 15.16 10.08 8 346360 100 79397920
Foetal death 15.15 10.08 8 346360 8036 79389984
Coronary artery disease 15.12 10.08 382 345986 65092 79332928
Hepatitis toxic 15.11 10.08 53 346315 5094 79392926
Blood immunoglobulin E increased 15.10 10.08 58 346310 5824 79392196
Cardiac amyloidosis 15.10 10.08 28 346340 1812 79396208
Endoscopy upper gastrointestinal tract abnormal 15.07 10.08 7 346361 65 79397955
Post procedural haematoma 15.06 10.08 33 346335 2409 79395611
Blindness 15.04 10.08 189 346179 28194 79369826
Retinal phototoxicity 15.02 10.08 4 346364 4 79398016
Renal artery stenosis 15.01 10.08 41 346327 3441 79394579
Primary hypoparathyroidism 15.01 10.08 6 346362 37 79397983
Ligament sprain 14.97 10.08 22 346346 13442 79384578
Fear of eating 14.92 10.08 14 346354 459 79397561
Normal newborn 14.92 10.08 6 346362 7066 79390954
Nerve compression 14.89 10.08 11 346357 9228 79388792
Anaemia megaloblastic 14.89 10.08 16 346352 619 79397401
Sensory loss 14.82 10.08 102 346266 12889 79385131
Drug screen positive 14.80 10.08 4 346364 6059 79391961
Hypertensive heart disease 14.75 10.08 46 346322 4160 79393860
Glomerular filtration rate 14.75 10.08 9 346359 151 79397869
Glomerular filtration rate increased 14.74 10.08 22 346346 1189 79396831
Catatonia 14.67 10.08 10 346358 8746 79389274
Influenza like illness 14.64 10.08 221 346147 71486 79326534
Linear IgA disease 14.64 10.08 38 346330 3094 79394926
Osteoma 14.62 10.08 8 346360 108 79397912
Poor venous access 14.62 10.08 36 346332 18113 79379907
Extradural haematoma 14.60 10.08 36 346332 2840 79395180
Arterial stenosis 14.58 10.08 24 346344 1412 79396608
Arterial occlusive disease 14.57 10.08 74 346294 8382 79389638
Anal haemorrhage 14.57 10.08 46 346322 4188 79393832
Hypogammaglobulinaemia 14.56 10.08 21 346347 12930 79385090
Bladder diverticulum 14.56 10.08 8 346360 109 79397911
Tricuspid valve calcification 14.55 10.08 4 346364 5 79398015
Thirst 14.54 10.08 134 346234 18485 79379535
Staphylococcal scalded skin syndrome 14.54 10.08 13 346355 400 79397620
Fluid intake reduced 14.54 10.08 60 346308 6228 79391792
Burns second degree 14.53 10.08 34 346334 2594 79395426
Cerebrovascular accident 14.51 10.08 819 345549 154473 79243547
Abdominal distension 14.49 10.08 402 345966 119248 79278772
Female genital tract fistula 14.47 10.08 4 346364 5971 79392049
Middle insomnia 14.47 10.08 30 346338 16039 79381981
Drug tolerance 14.42 10.08 10 346358 8665 79389355
Supraventricular tachyarrhythmia 14.37 10.08 8 346360 112 79397908
Cardiac dysfunction 14.37 10.08 45 346323 4079 79393941
Joint effusion 14.30 10.08 36 346332 17978 79380042
Normochromic normocytic anaemia 14.29 10.08 69 346299 7658 79390362
Ecchymosis 14.28 10.08 114 346254 15092 79382928
Catheter site pain 14.27 10.08 3 346365 5393 79392627
Renal function test abnormal 14.27 10.08 51 346317 4947 79393073
Blood glucose decreased 14.22 10.08 62 346306 26172 79371848
Laboratory test abnormal 14.18 10.08 68 346300 27980 79370040
Immunosuppression 14.16 10.08 21 346347 12782 79385238
Thinking abnormal 14.16 10.08 22 346346 13139 79384881
Skin hyperpigmentation 14.14 10.08 7 346361 7296 79390724
Motor dysfunction 14.13 10.08 111 346257 14622 79383398
Pericardial disease 14.13 10.08 15 346353 572 79397448
Discoloured vomit 14.07 10.08 24 346344 1454 79396566
Prurigo 14.06 10.08 23 346345 1346 79396674
Subclavian artery occlusion 14.05 10.08 9 346359 165 79397855
Pelvi-ureteric obstruction 14.04 10.08 7 346361 77 79397943
Hepatitis 14.04 10.08 329 346039 55398 79342622
Pleuritic pain 14.03 10.08 14 346354 10138 79387882
Bladder tamponade 14.03 10.08 15 346353 577 79397443
Eyelid retraction 14.02 10.08 6 346362 45 79397975
Aortic valve calcification 13.99 10.08 17 346351 753 79397267
Musculoskeletal discomfort 13.98 10.08 42 346326 19793 79378227
Nephrosclerosis 13.97 10.08 27 346341 1803 79396217
Gonorrhoea 13.88 10.08 10 346358 224 79397796
X-ray abnormal 13.88 10.08 4 346364 5809 79392211
Putamen haemorrhage 13.87 10.08 14 346354 503 79397517
Hyperkaliuria 13.86 10.08 9 346359 169 79397851
Mechanical urticaria 13.86 10.08 13 346355 426 79397594
Laryngeal discomfort 13.86 10.08 15 346353 585 79397435
Gastrointestinal angiodysplasia 13.85 10.08 20 346348 1049 79396971
Spinal stenosis 13.78 10.08 30 346338 15761 79382259
Urinary tract infection 13.78 10.08 1016 345352 273496 79124524
Skin discolouration 13.74 10.08 113 346255 40921 79357099
Localised infection 13.74 10.08 101 346267 37474 79360546
Hypertrophic cardiomyopathy 13.73 10.08 31 346337 2309 79395711
Trifascicular block 13.73 10.08 9 346359 172 79397848
Hypochromasia 13.68 10.08 16 346352 680 79397340
Haemorrhage subcutaneous 13.67 10.08 49 346319 4760 79393260
Dermatitis exfoliative generalised 13.64 10.08 65 346303 7176 79390844
Impaired work ability 13.64 10.08 42 346326 19639 79378381
Chest X-ray abnormal 13.59 10.08 69 346299 7814 79390206
Intentional dose omission 13.58 10.08 11 346357 8806 79389214
Hepatitis fulminant 13.54 10.08 65 346303 7197 79390823
Brain natriuretic peptide abnormal 13.52 10.08 17 346351 780 79397240
Venous pressure jugular decreased 13.51 10.08 7 346361 84 79397936
Vascular stent occlusion 13.51 10.08 10 346358 234 79397786
Drug specific antibody present 13.46 10.08 6 346362 6646 79391374
Postictal paralysis 13.46 10.08 12 346356 368 79397652
Vaginal haemorrhage 13.45 10.08 49 346319 21768 79376252
Device pacing issue 13.44 10.08 8 346360 128 79397892
Product selection error 13.43 10.08 10 346358 236 79397784
Procedural haemorrhage 13.42 10.08 48 346320 4658 79393362
Activated partial thromboplastin time shortened 13.41 10.08 18 346350 881 79397139
Gastric ulcer perforation 13.34 10.08 29 346339 2106 79395914
Trepopnoea 13.33 10.08 3 346365 0 79398020
Hyperkinetic heart syndrome 13.33 10.08 8 346360 130 79397890
Spleen scan abnormal 13.33 10.08 3 346365 0 79398020
Anal polyp 13.30 10.08 7 346361 87 79397933
Base excess decreased 13.30 10.08 12 346356 374 79397646
Infarction 13.29 10.08 47 346321 4535 79393485
Adenomatous polyposis coli 13.29 10.08 10 346358 240 79397780
Hormone receptor positive HER2 negative breast cancer 13.28 10.08 8 346360 131 79397889
Gastric pH increased 13.27 10.08 6 346362 52 79397968
Abnormal behaviour 13.27 10.08 98 346270 36323 79361697
Administration site discomfort 13.22 10.08 8 346360 132 79397888
Calcification metastatic 13.17 10.08 8 346360 133 79397887
Endocarditis 13.17 10.08 85 346283 10512 79387508
Tuberculosis 13.16 10.08 29 346339 15169 79382851
Bronchiectasis 13.15 10.08 152 346216 22234 79375786
Sinus tachycardia 13.12 10.08 100 346268 36808 79361212
Mucosal inflammation 13.12 10.08 240 346128 75340 79322680
Transitional cell carcinoma 13.10 10.08 32 346336 2509 79395511
Abnormal precordial movement 13.10 10.08 4 346364 9 79398011
First trimester pregnancy 13.10 10.08 4 346364 9 79398011
Anger 13.08 10.08 35 346333 17127 79380893
Right atrial enlargement 13.06 10.08 12 346356 383 79397637
Pericarditis constrictive 13.03 10.08 15 346353 627 79397393
Mesenteric artery thrombosis 13.03 10.08 15 346353 627 79397393
Coma 13.01 10.08 548 345820 100101 79297919
Facial paresis 12.99 10.08 53 346315 5473 79392547
Secondary hyperthyroidism 12.99 10.08 6 346362 55 79397965
Peripheral sensory neuropathy 12.95 10.08 99 346269 12934 79385086
Dyspepsia 12.94 10.08 366 346002 108321 79289699
Wrong dose 12.94 10.08 25 346343 1669 79396351
Product administered to patient of inappropriate age 12.93 10.08 4 346364 5549 79392471
Bullous haemorrhagic dermatosis 12.89 10.08 7 346361 93 79397927
Sexual dysfunction 12.83 10.08 9 346359 7754 79390266
Orbital swelling 12.80 10.08 6 346362 57 79397963
Intrapericardial thrombosis 12.80 10.08 6 346362 57 79397963
Iron metabolism disorder 12.80 10.08 6 346362 57 79397963
Plasma cell myeloma recurrent 12.78 10.08 3 346365 4998 79393022
Incorrect dose administered by device 12.74 10.08 3 346365 4986 79393034
Cytomegalovirus chorioretinitis 12.71 10.08 4 346364 5486 79392534
C-reactive protein 12.70 10.08 3 346365 4976 79393044
Mydriasis 12.70 10.08 37 346331 17606 79380414
Endophthalmitis 12.70 10.08 6 346362 6422 79391598
Pancytopenia 12.67 10.08 859 345509 164886 79233134
Bipolar disorder 12.65 10.08 9 346359 7698 79390322
Tetany 12.65 10.08 33 346335 2695 79395325
Femoral artery aneurysm 12.59 10.08 9 346359 199 79397821
Sleep disorder due to a general medical condition 12.56 10.08 27 346341 14250 79383770
Disease complication 12.54 10.08 3 346365 4934 79393086
Thrombin time prolonged 12.51 10.08 11 346357 331 79397689
Acute graft versus host disease in skin 12.50 10.08 9 346359 7649 79390371
Restlessness 12.49 10.08 277 346091 46215 79351805
Electrocardiogram ST segment depression 12.44 10.08 48 346320 4830 79393190
Saliva altered 12.43 10.08 13 346355 487 79397533
Change of bowel habit 12.43 10.08 33 346335 2724 79395296
Tenosynovitis 12.41 10.08 31 346337 15523 79382497
Granulocytopenia 12.40 10.08 19 346349 11412 79386608
Haematotoxicity 12.33 10.08 31 346337 15488 79382532
Nephroangiosclerosis 12.32 10.08 11 346357 338 79397682
Psychogenic visual disorder 12.22 10.08 5 346363 33 79397987
Haemophagocytic lymphohistiocytosis 12.21 10.08 51 346317 21786 79376234
Blood pressure ambulatory increased 12.20 10.08 6 346362 64 79397956
Cardiac autonomic neuropathy 12.20 10.08 6 346362 64 79397956
Walking disability 12.15 10.08 28 346340 2115 79395905
Articular calcification 12.14 10.08 9 346359 211 79397809
Loss of proprioception 12.13 10.08 16 346352 770 79397250
Dysaesthesia 12.13 10.08 54 346314 5794 79392226
Lymphocyte count decreased 12.13 10.08 139 346229 47150 79350870
Lip oedema 12.12 10.08 57 346311 6259 79391761
Feeling of body temperature change 12.11 10.08 4 346364 5322 79392698
Cardiomegaly 12.11 10.08 171 346197 26181 79371839
Weight fluctuation 12.10 10.08 20 346348 11655 79386365
Toxic epidermal necrolysis 12.10 10.08 266 346102 44315 79353705
Urinary bladder haemorrhage 12.09 10.08 31 346337 2505 79395515
Foetal exposure during pregnancy 12.07 10.08 5 346363 5785 79392235
Retrograde amnesia 12.05 10.08 14 346354 591 79397429
Blood pressure inadequately controlled 12.04 10.08 56 346312 6121 79391899
Ventricular dysfunction 12.03 10.08 55 346313 5968 79392052
Tardive dyskinesia 12.03 10.08 17 346351 10554 79387466
Impaired quality of life 12.01 10.08 28 346340 14358 79383662
Vitamin B12 decreased 11.98 10.08 38 346330 3467 79394553
Pericardial fibrosis 11.93 10.08 8 346360 159 79397861
Sputum culture 11.92 10.08 9 346359 217 79397803
Haemorrhagic transformation stroke 11.91 10.08 32 346336 2660 79395360
Eye haematoma 11.89 10.08 8 346360 160 79397860
Amaurosis fugax 11.85 10.08 17 346351 886 79397134
Blood aldosterone increased 11.85 10.08 9 346359 219 79397801
Traumatic haemorrhage 11.85 10.08 21 346347 1312 79396708
Catarrh 11.84 10.08 28 346340 2150 79395870
Axonal neuropathy 11.82 10.08 27 346341 2027 79395993
Tooth infection 11.80 10.08 42 346326 18790 79379230
Spinal fusion surgery 11.80 10.08 4 346364 5234 79392786
Hypernatraemia 11.80 10.08 105 346263 14346 79383674
Eye swelling 11.79 10.08 67 346301 26401 79371619
Infusion site extravasation 11.75 10.08 16 346352 10092 79387928
Cardiovascular somatic symptom disorder 11.74 10.08 5 346363 37 79397983
Device related infection 11.69 10.08 94 346274 34200 79363820
Red cell distribution width abnormal 11.68 10.08 9 346359 224 79397796
Coronavirus test positive 11.64 10.08 19 346349 1110 79396910
Lymphadenopathy 11.61 10.08 162 346206 53085 79344935
Troponin I increased 11.58 10.08 46 346322 4692 79393328
Oxygen consumption decreased 11.51 10.08 12 346356 448 79397572
Polyomavirus-associated nephropathy 11.51 10.08 5 346363 5622 79392398
Cataract 11.50 10.08 195 346173 61925 79336095
Thyroiditis 11.49 10.08 45 346323 4560 79393460
Small fibre neuropathy 11.49 10.08 13 346355 533 79397487
Perihepatic abscess 11.47 10.08 8 346360 170 79397850
Cerebral artery occlusion 11.46 10.08 24 346344 1698 79396322
Hypereosinophilic syndrome 11.45 10.08 13 346355 535 79397485
Genital herpes simplex 11.44 10.08 11 346357 372 79397648
Ischaemia 11.44 10.08 67 346301 8008 79390012
Diffuse vasculitis 11.44 10.08 7 346361 118 79397902
Transferrin saturation decreased 11.43 10.08 19 346349 1127 79396893
Splenic necrosis 11.43 10.08 8 346360 171 79397849
Echocardiogram abnormal 11.43 10.08 28 346340 2200 79395820
Sudden cardiac death 11.41 10.08 49 346319 5176 79392844
Hernia 11.40 10.08 37 346331 17022 79380998
Basilar artery thrombosis 11.39 10.08 11 346357 374 79397646
Bilirubin conjugated abnormal 11.39 10.08 7 346361 119 79397901
Oral pain 11.38 10.08 86 346282 31712 79366308
Post procedural infection 11.34 10.08 20 346348 11364 79386656
Low cardiac output syndrome 11.34 10.08 18 346350 1027 79396993
Bronchopulmonary aspergillosis 11.30 10.08 54 346314 22240 79375780
Paresis cranial nerve 11.30 10.08 5 346363 41 79397979
Pre-existing condition improved 11.29 10.08 5 346363 5558 79392462
Wound infection pseudomonas 11.27 10.08 23 346345 1598 79396422
Electrocardiogram change 11.27 10.08 20 346348 1251 79396769
Pacemaker generated arrhythmia 11.26 10.08 3 346365 3 79398017
Cardiac valve fibroelastoma 11.26 10.08 3 346365 3 79398017
Cerebrovascular arteriovenous malformation 11.24 10.08 7 346361 122 79397898
Sinus headache 11.24 10.08 4 346364 5076 79392944
Skin infection 11.23 10.08 41 346327 18204 79379816
Orthostatic hypertension 11.23 10.08 16 346352 829 79397191
Nocturnal dyspnoea 11.22 10.08 23 346345 1603 79396417
Failure to suspend medication 11.21 10.08 12 346356 462 79397558
Intestinal obstruction 11.21 10.08 126 346242 42894 79355126
Ankle fracture 11.21 10.08 37 346331 16932 79381088
Tremor 11.21 10.08 614 345754 169469 79228551
Suspected product quality issue 11.21 10.08 10 346358 307 79397713
Cholecystitis chronic 11.20 10.08 16 346352 9890 79388130
Areflexia 11.19 10.08 5 346363 5529 79392491
Cardiac hypertrophy 11.18 10.08 23 346345 1607 79396413
Gingival bleeding 11.17 10.08 114 346254 16162 79381858
Mean cell haemoglobin concentration 11.10 10.08 5 346363 43 79397977
Cardio-respiratory arrest 11.07 10.08 373 345995 108137 79289883
Red cell distribution width increased 11.06 10.08 108 346260 15134 79382886
Cerebral artery embolism 11.04 10.08 25 346343 1866 79396154
Kidney infection 11.03 10.08 53 346315 21798 79376222
Mucosal membrane hyperplasia 11.00 10.08 5 346363 44 79397976
Meniscus injury 10.99 10.08 8 346360 6760 79391260
Decreased immune responsiveness 10.98 10.08 5 346363 5470 79392550
Cardiac ventricular thrombosis 10.98 10.08 24 346344 1749 79396271
Infusion site erythema 10.98 10.08 15 346353 9445 79388575
Arterial intramural haematoma 10.97 10.08 6 346362 81 79397939
Neovascular age-related macular degeneration 10.95 10.08 11 346357 393 79397627
Coma acidotic 10.94 10.08 7 346361 128 79397892
Peripheral artery occlusion 10.92 10.08 30 346338 2527 79395493
Small cell carcinoma 10.91 10.08 10 346358 318 79397702
Nervous system disorder 10.91 10.08 70 346298 26786 79371234
Tracheal pain 10.90 10.08 5 346363 45 79397975
Gait disturbance 10.90 10.08 765 345603 206741 79191279
Long QT syndrome 10.89 10.08 53 346315 5902 79392118
Pseudofolliculitis 10.86 10.08 4 346364 19 79398001
Pseudohyponatraemia 10.85 10.08 7 346361 130 79397890
Hyperaesthesia 10.85 10.08 23 346345 12199 79385821
Staphylococcal bacteraemia 10.84 10.08 23 346345 12195 79385825
Oesophageal infection 10.84 10.08 14 346354 660 79397360
Acute myeloid leukaemia 10.83 10.08 84 346284 30801 79367219
Pulmonary pain 10.82 10.08 3 346365 4470 79393550
Jaundice cholestatic 10.81 10.08 85 346283 11199 79386821
Thrombolysis 10.81 10.08 9 346359 251 79397769
Adrenomegaly 10.79 10.08 11 346357 400 79397620
Muscle rigidity 10.77 10.08 47 346321 19835 79378185
Nervousness 10.75 10.08 93 346275 33322 79364698
Left ventricle outflow tract obstruction 10.74 10.08 11 346357 402 79397618
Varicella zoster virus infection 10.71 10.08 3 346365 4438 79393582
Neuralgia 10.70 10.08 93 346275 33291 79364729
Apheresis related complication 10.69 10.08 4 346364 20 79398000
Hyperhidrosis 10.69 10.08 780 345588 150712 79247308
Splenic cyst 10.69 10.08 9 346359 255 79397765
Finger deformity 10.69 10.08 10 346358 7464 79390556
Splinter haemorrhages 10.67 10.08 7 346361 134 79397886
Oral candidiasis 10.66 10.08 80 346288 29548 79368472
Polyserositis 10.66 10.08 14 346354 671 79397349
Human herpesvirus 6 infection 10.63 10.08 5 346363 5365 79392655
Cyanosis 10.62 10.08 161 346207 25021 79372999
Hypertensive cardiomyopathy 10.60 10.08 10 346358 330 79397690
Hyperammonaemia 10.60 10.08 20 346348 11073 79386947
Thyroiditis acute 10.60 10.08 8 346360 193 79397827
Neck mass 10.57 10.08 3 346365 4401 79393619
Discharge 10.55 10.08 21 346347 1433 79396587
Genital herpes zoster 10.54 10.08 4 346364 21 79397999
Anal paraesthesia 10.54 10.08 4 346364 21 79397999
Urinary straining 10.53 10.08 5 346363 49 79397971
Paroxysmal arrhythmia 10.53 10.08 5 346363 49 79397971
Drug level decreased 10.51 10.08 30 346338 14372 79383648
Hereditary angioedema 10.51 10.08 5 346363 5330 79392690
Intra-abdominal haematoma 10.49 10.08 32 346336 2859 79395161
Dermatitis contact 10.45 10.08 20 346348 11013 79387007
Osteocalcin decreased 10.45 10.08 5 346363 50 79397970
Skin turgor decreased 10.44 10.08 15 346353 783 79397237
Kussmaul respiration 10.44 10.08 11 346357 416 79397604
Wrong product administered 10.42 10.08 71 346297 8941 79389079
Intermittent claudication 10.41 10.08 36 346332 3435 79394585
Muscle enzyme increased 10.39 10.08 11 346357 418 79397602
Blood lactate dehydrogenase 10.38 10.08 4 346364 22 79397998
Aspartate aminotransferase increased 10.38 10.08 494 345874 138147 79259873
Platelet aggregation decreased 10.36 10.08 5 346363 51 79397969
Tooth extraction 10.35 10.08 20 346348 10975 79387045
Peripartum cardiomyopathy 10.32 10.08 7 346361 142 79397878
Bundle branch block 10.30 10.08 22 346346 1578 79396442
Systolic hypertension 10.30 10.08 14 346354 694 79397326
Vitamin D deficiency 10.28 10.08 101 346267 14178 79383842
Hepatitis B reactivation 10.20 10.08 7 346361 6101 79391919
Periorbital inflammation 10.19 10.08 6 346362 94 79397926
Post-traumatic headache 10.13 10.08 6 346362 95 79397925
Cogwheel rigidity 10.12 10.08 33 346335 3055 79394965
Prohormone brain natriuretic peptide increased 10.12 10.08 9 346359 275 79397745

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Small for dates baby 31.92 30.45 41 248 2768 86735

Pharmacologic Action:

SourceCodeDescription
ATC C07AB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07FB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FX04 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C09BX02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
CHEBI has role CHEBI:35530 beta-adrenergic blockers
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:66991 sympatholytic drug
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013565 Sympatholytics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Chronic heart failure off-label use 48447003
Angina pectoris off-label use 194828000
Diastolic heart failure off-label use 418304008 DOID:9775
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Anuria contraindication 2472002 DOID:2983
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Hypomagnesemia contraindication 190855004
Partial atrioventricular block contraindication 195039008
Decompensated cardiac failure contraindication 195111005
Asthma contraindication 195967001 DOID:2841
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Severe chronic obstructive pulmonary disease contraindication 313299006
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Azotemia contraindication 445009001
Acute exacerbation of asthma contraindication 708038006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.65 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.94 WOMBAT-PK
Beta-3 adrenergic receptor GPCR Ki 5.04 WOMBAT-PK
Beta-1 adrenergic receptor GPCR Ki 8.28 CHEMBL

External reference:

IDSource
4023923 VUID
N0000021928 NUI
D00634 KEGG_DRUG
104344-23-2 SECONDARY_CAS_RN
142146 RXNORM
C0053799 UMLSCUI
CHEBI:3127 CHEBI
CHEMBL645 ChEMBL_ID
CHEMBL1472989 ChEMBL_ID
DB00612 DRUGBANK_ID
CHEMBL1200708 ChEMBL_ID
D017298 MESH_DESCRIPTOR_UI
2405 PUBCHEM_CID
7129 IUPHAR_LIGAND_ID
5225 INN_ID
Y41JS2NL6U UNII
38369 MMSL
4291 MMSL
d00709 MMSL
108547003 SNOMEDCT_US
386868003 SNOMEDCT_US
386869006 SNOMEDCT_US
4020862 VANDF
4023923 VANDF
003703 NDDF
003704 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3241 TABLET, FILM COATED 2.50 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3241 TABLET, FILM COATED 2.50 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3242 TABLET, FILM COATED 5 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3242 TABLET, FILM COATED 5 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3243 TABLET, FILM COATED 10 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3243 TABLET, FILM COATED 10 mg ORAL NDA authorized generic 23 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0501 TABLET, FILM COATED 2.50 mg ORAL ANDA 26 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0503 TABLET, FILM COATED 5 mg ORAL ANDA 26 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0505 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10135-740 TABLET 2.50 mg ORAL ANDA 19 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10135-740 TABLET 2.50 mg ORAL ANDA 19 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10135-741 TABLET 5 mg ORAL ANDA 19 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10135-741 TABLET 5 mg ORAL ANDA 19 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10135-742 TABLET 10 mg ORAL ANDA 19 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10135-742 TABLET 10 mg ORAL ANDA 19 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-173 TABLET 2.50 mg ORAL ANDA 20 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-174 TABLET 10 mg ORAL ANDA 20 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-563 TABLET 5 mg ORAL ANDA 20 sections
BISOPROLOL FUMARATE Human Prescription Drug Label 1 15955-373 TABLET, FILM COATED 5 mg ORAL ANDA 11 sections
BISOPROLOL FUMARATE Human Prescription Drug Label 1 15955-374 TABLET, FILM COATED 10 mg ORAL ANDA 11 sections
Bisoprolol Fumarate Human Prescription Drug Label 1 16714-529 TABLET, FILM COATED 5 mg ORAL ANDA 18 sections
Bisoprolol Fumarate Human Prescription Drug Label 1 16714-530 TABLET, FILM COATED 10 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 21695-667 TABLET 5 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 21695-670 TABLET 10 mg ORAL ANDA 18 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 21695-808 TABLET, COATED 5 mg ORAL ANDA 23 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 21695-809 TABLET, COATED 10 mg ORAL ANDA 23 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 29300-126 TABLET 5 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 29300-126 TABLET 5 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 29300-127 TABLET 10 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 29300-127 TABLET 10 mg ORAL ANDA 18 sections