bisoprolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 380 66722-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bisoprolol hemifumarate
  • bisoprolol
  • bisoprolol fumarate
A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.
  • Molecular weight: 325.45
  • Formula: C18H31NO4
  • CLOGP: 1.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 59.95
  • ALOGS: -3.66
  • ROTB: 12

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 63 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.88 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.66 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 31, 1992 FDA TEVA WOMENS
June 28, 2013 PMDA TOA EIYO LTD.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 1401.50 10.24 2563 150462 251305 52944736
Bradycardia 1127.40 10.24 1196 151829 69860 53126181
Drug interaction 751.41 10.24 1824 151201 217505 52978536
Cardiac failure 738.67 10.24 1062 151963 84782 53111259
General physical health deterioration 607.61 10.24 1317 151708 145625 53050416
Hyperkalaemia 576.81 10.24 744 152281 53512 53142529
Hyponatraemia 555.07 10.24 1063 151962 107544 53088497
Atrial fibrillation 551.33 10.24 1077 151948 110575 53085466
Rheumatoid arthritis 438.64 10.24 177 152848 314354 52881687
Hypotension 413.54 10.24 1630 151395 252446 52943595
Pain 408.72 10.24 663 152362 587735 52608306
Drug ineffective 408.65 10.24 1111 151914 816134 52379907
Lactic acidosis 391.36 10.24 508 152517 36745 53159296
Syncope 344.37 10.24 895 152130 111098 53084943
Melaena 338.90 10.24 418 152607 28711 53167330
International normalised ratio increased 289.96 10.24 504 152521 47257 53148784
Sinusitis 274.94 10.24 72 152953 168492 53027549
Ischaemic stroke 272.81 10.24 296 152729 17697 53178344
Completed suicide 253.91 10.24 45 152980 138156 53057885
Pemphigus 248.11 10.24 12 153013 104019 53092022
Anaemia 247.53 10.24 1496 151529 275222 52920819
Therapeutic product effect decreased 239.54 10.24 37 152988 125618 53070423
Abdominal discomfort 237.08 10.24 173 152852 220889 52975152
Maternal exposure during pregnancy 232.80 10.24 78 152947 155561 53040480
Systemic lupus erythematosus 227.86 10.24 42 152983 125372 53070669
Haematoma 222.38 10.24 370 152655 33474 53162567
Glossodynia 220.02 10.24 18 153007 100273 53095768
Hypertensive crisis 215.32 10.24 236 152789 14270 53181771
Cerebral haemorrhage 212.08 10.24 339 152686 29657 53166384
Product dose omission issue 211.96 10.24 145 152880 191475 53004566
Arthropathy 211.35 10.24 71 152954 141382 53054659
Drug hypersensitivity 206.74 10.24 275 152750 264967 52931074
Hand deformity 204.88 10.24 9 153016 84840 53111201
Treatment failure 203.41 10.24 58 152967 128345 53067696
Joint swelling 203.26 10.24 224 152801 234414 52961627
Sinus bradycardia 193.60 10.24 224 152801 14377 53181664
Sopor 193.09 10.24 269 152756 20815 53175226
Hypoglycaemia 193.03 10.24 483 152542 58530 53137511
Swelling 191.63 10.24 160 152865 190945 53005096
Arrhythmia 187.58 10.24 360 152665 36419 53159622
Confusional state 185.01 10.24 1068 151957 193153 53002888
Alopecia 184.01 10.24 242 152783 234341 52961700
Rhabdomyolysis 180.31 10.24 393 152632 43530 53152511
Atrioventricular block complete 179.32 10.24 163 152862 7852 53188189
Fall 172.52 10.24 1676 151349 356764 52839277
Orthostatic hypotension 170.24 10.24 306 152719 29447 53166594
Hypokalaemia 169.42 10.24 635 152390 95882 53100159
Exposure during pregnancy 166.15 10.24 75 152950 124785 53071256
Electrocardiogram QT prolonged 161.26 10.24 439 152586 55964 53140077
Product prescribing error 161.04 10.24 259 152766 22772 53173269
Atrioventricular block 159.34 10.24 145 152880 6995 53189046
Synovitis 157.95 10.24 56 152969 107837 53088204
Infusion related reaction 155.79 10.24 131 152894 155826 53040215
Haematemesis 150.00 10.24 296 152729 30561 53165480
Death 145.41 10.24 531 152494 356701 52839340
Injection site pain 144.89 10.24 72 152953 113319 53082722
Product use issue 144.70 10.24 113 152912 139471 53056570
Renal failure 139.70 10.24 691 152334 117761 53078280
Cardiac failure chronic 136.06 10.24 104 152921 3926 53192115
Arthralgia 135.31 10.24 726 152299 439057 52756984
Drug intolerance 135.09 10.24 239 152786 205254 52990787
Rash 129.42 10.24 751 152274 445440 52750601
Left ventricular dysfunction 128.64 10.24 160 152865 11077 53184964
Hypomagnesaemia 127.91 10.24 244 152781 24567 53171474
Rectal haemorrhage 127.82 10.24 332 152693 41149 53154892
Cardiogenic shock 125.52 10.24 199 152826 17283 53178758
Tachyarrhythmia 123.73 10.24 105 152920 4611 53191430
Renal impairment 123.50 10.24 520 152505 82798 53113243
International normalised ratio fluctuation 122.42 10.24 79 152946 2264 53193777
Shock haemorrhagic 121.93 10.24 141 152884 9042 53186999
Upper gastrointestinal haemorrhage 121.84 10.24 196 152829 17234 53178807
Headache 119.85 10.24 976 152049 535845 52660196
Presyncope 118.63 10.24 244 152781 25950 53170091
Injection site erythema 118.47 10.24 37 152988 77212 53118829
Circulatory collapse 115.39 10.24 222 152803 22492 53173549
Subdural haematoma 112.93 10.24 167 152858 13646 53182395
Nasopharyngitis 112.18 10.24 240 152785 192055 53003986
Anuria 111.34 10.24 157 152868 12283 53183758
Bradyarrhythmia 107.02 10.24 69 152956 1974 53194067
Ejection fraction decreased 100.84 10.24 194 152831 19654 53176387
Fatigue 100.29 10.24 1485 151540 729021 52467020
Cerebral infarction 97.22 10.24 216 152809 24228 53171813
Mitral valve incompetence 96.77 10.24 189 152836 19362 53176679
Dyspnoea 96.60 10.24 2279 150746 583953 52612088
Contraindicated product administered 96.27 10.24 150 152875 135479 53060562
Vertigo 95.88 10.24 366 152659 55715 53140326
Migraine 95.49 10.24 56 152969 80361 53115680
Pericarditis 94.98 10.24 33 152992 64373 53131668
Hypersensitivity 93.10 10.24 302 152723 210363 52985678
Angina pectoris 90.64 10.24 232 152793 28493 53167548
Injection site pruritus 89.72 10.24 8 153017 41581 53154460
Haematochezia 89.17 10.24 296 152729 42062 53153979
Helicobacter infection 88.54 10.24 6 153019 39063 53156978
Dehydration 86.96 10.24 800 152225 167610 53028431
Psoriatic arthropathy 85.65 10.24 17 153008 48173 53147868
Torsade de pointes 85.16 10.24 142 152883 12863 53183178
Oedema peripheral 83.05 10.24 801 152224 169986 53026055
Acute coronary syndrome 82.31 10.24 124 152901 10300 53185741
Injection site reaction 81.19 10.24 23 153002 51143 53144898
Hypocalcaemia 80.50 10.24 225 152800 29112 53166929
Asthma 79.75 10.24 118 152907 108854 53087187
Adverse drug reaction 78.17 10.24 28 152997 53597 53142444
Polyneuropathy 76.83 10.24 137 152888 13096 53182945
Discomfort 76.28 10.24 97 152928 95375 53100666
Abortion spontaneous 75.80 10.24 20 153005 46615 53149426
Insomnia 74.68 10.24 280 152745 186792 53009249
Irritable bowel syndrome 72.29 10.24 18 153007 43614 53152427
Cardioactive drug level increased 72.00 10.24 55 152970 2074 53193967
Gastrointestinal haemorrhage 71.34 10.24 434 152591 79896 53116145
Cholestasis 70.94 10.24 212 152813 28483 53167558
Pregnancy 70.75 10.24 5 153020 31436 53164605
Systemic infection 69.45 10.24 54 152971 2091 53193950
Sinus node dysfunction 68.29 10.24 73 152952 4288 53191753
Hallucination, visual 67.79 10.24 160 152865 18672 53177369
Unevaluable event 66.96 10.24 29 152996 49469 53146572
Acute myocardial infarction 65.33 10.24 227 152798 33008 53163033
Vasoplegia syndrome 64.88 10.24 42 152983 1210 53194831
Atrial flutter 64.51 10.24 106 152919 9485 53186556
Hepatocellular injury 64.41 10.24 211 152814 29775 53166266
Duodenal ulcer perforation 63.39 10.24 12 153013 35171 53160870
Hospitalisation 63.37 10.24 66 152959 70946 53125095
Neuropathy peripheral 62.47 10.24 126 152899 103061 53092980
Pain in extremity 62.13 10.24 521 152504 284529 52911512
Hyponatraemic syndrome 61.02 10.24 32 152993 614 53195427
Depression 60.16 10.24 295 152730 182757 53013284
Off label use 59.77 10.24 974 152051 471238 52724803
Mental status changes 58.81 10.24 20 153005 39551 53156490
Myopathy 58.41 10.24 102 152923 9590 53186451
Bloody discharge 58.21 10.24 39 152986 1192 53194849
Musculoskeletal stiffness 57.89 10.24 172 152853 123196 53072845
Glomerular filtration rate decreased 57.89 10.24 119 152906 12648 53183393
Pallor 57.54 10.24 181 152844 25001 53171040
Medication error 57.02 10.24 231 152794 36134 53159907
White blood cell count decreased 56.65 10.24 176 152849 124299 53071742
Subarachnoid haemorrhage 56.47 10.24 113 152912 11780 53184261
Hemiplegia 56.28 10.24 89 152936 7711 53188330
Renin increased 56.12 10.24 21 153004 170 53195871
Epistaxis 55.27 10.24 362 152663 68348 53127693
Infection 55.16 10.24 280 152745 171925 53024116
Eosinophilia 55.00 10.24 160 152865 21175 53174866
Labelled drug-drug interaction medication error 54.71 10.24 106 152919 10793 53185248
Folliculitis 54.67 10.24 12 153013 31697 53164344
Stress 54.47 10.24 50 152975 57034 53139007
Jaundice 54.43 10.24 201 152824 30112 53165929
Hemiparesis 54.36 10.24 160 152865 21315 53174726
Peripheral swelling 54.30 10.24 357 152668 205751 52990290
Ventricular fibrillation 53.89 10.24 111 152914 11814 53184227
Wound 53.56 10.24 114 152911 91443 53104598
Wrong patient received product 53.02 10.24 46 152979 2082 53193959
Product quality issue 52.83 10.24 20 153005 37003 53159038
Asthenia 52.49 10.24 1323 151702 342267 52853774
Disease progression 52.35 10.24 136 152889 101784 53094257
Anxiety 52.18 10.24 340 152685 196364 52999677
Hypovolaemic shock 52.11 10.24 72 152953 5525 53190516
Electrolyte imbalance 51.97 10.24 145 152880 18739 53177302
Knee arthroplasty 51.59 10.24 16 153009 33553 53162488
Upper respiratory tract infection 51.34 10.24 74 152951 69023 53127018
Cardiac failure acute 51.34 10.24 93 152932 8999 53187042
Urinary retention 51.32 10.24 189 152836 28277 53167764
Injection site bruising 51.01 10.24 22 153003 37624 53158417
Erysipelas 50.88 10.24 82 152943 7219 53188822
Metabolic acidosis 50.85 10.24 248 152777 41994 53154047
Injection site swelling 48.76 10.24 31 152994 42597 53153444
Microcytic anaemia 48.37 10.24 54 152971 3331 53192710
Arthritis 48.35 10.24 112 152913 87186 53108855
Prerenal failure 48.32 10.24 39 152986 1595 53194446
Hip arthroplasty 47.12 10.24 11 153014 27851 53168190
Gamma-glutamyltransferase increased 47.04 10.24 206 152819 33349 53162692
Plasma cell myeloma 46.79 10.24 41 152984 47833 53148208
Disorientation 46.61 10.24 230 152795 39129 53156912
Atrioventricular block first degree 46.37 10.24 74 152951 6461 53189580
Colitis erosive 46.36 10.24 15 153010 74 53195967
Back pain 46.24 10.24 439 152586 233808 52962233
Hypoaesthesia 45.62 10.24 211 152814 132784 53063257
Haemarthrosis 44.74 10.24 51 152974 3219 53192822
Vital capacity decreased 44.58 10.24 31 152994 1008 53195033
Feeling abnormal 44.46 10.24 218 152807 135083 53060958
Coma scale abnormal 44.35 10.24 64 152961 5114 53190927
Adverse event 44.10 10.24 32 152993 41029 53155012
Agranulocytosis 43.92 10.24 159 152866 23590 53172451
Hypothermia 43.85 10.24 108 152917 12948 53183093
Iron deficiency anaemia 43.79 10.24 135 152890 18445 53177596
Polyuria 43.51 10.24 80 152945 7831 53188210
No adverse event 42.96 10.24 30 152995 39235 53156806
Congestive cardiomyopathy 42.86 10.24 69 152956 6069 53189972
Tachycardia 42.85 10.24 487 152538 107725 53088316
Weight increased 42.25 10.24 379 152646 204188 52991853
Device issue 42.11 10.24 6 153019 21652 53174389
Bradyphrenia 41.93 10.24 72 152953 6678 53189363
Therapy cessation 41.93 10.24 14 153011 28011 53168030
Fibromyalgia 41.58 10.24 39 152986 44036 53152005
Toxic epidermal necrolysis 41.31 10.24 155 152870 23395 53172646
Haemorrhage intracranial 41.25 10.24 107 152918 13245 53182796
Haematuria 41.11 10.24 176 152849 28213 53167828
Pleural effusion 40.83 10.24 411 152614 88168 53107873
Multiple sclerosis relapse 40.79 10.24 41 152984 44812 53151229
Transaminases increased 40.74 10.24 183 152842 29949 53166092
Therapeutic response decreased 40.46 10.24 46 152979 47523 53148518
Flushing 40.38 10.24 89 152936 70511 53125530
Embolic stroke 40.17 10.24 52 152973 3747 53192294
Faecaloma 39.97 10.24 79 152946 8162 53187879
Lupus vasculitis 39.71 10.24 22 153003 473 53195568
Psoriasis 39.71 10.24 123 152902 86966 53109075
Acute cutaneous lupus erythematosus 39.66 10.24 18 153007 248 53195793
Loss of consciousness 39.53 10.24 501 152524 113711 53082330
Bronchitis 39.29 10.24 176 152849 111723 53084318
N-terminal prohormone brain natriuretic peptide increased 39.25 10.24 37 152988 1867 53194174
Haemorrhagic stroke 39.22 10.24 64 152961 5694 53190347
Cerebral ischaemia 38.69 10.24 69 152956 6596 53189445
Left ventricular failure 38.68 10.24 61 152964 5272 53190769
Acute pulmonary oedema 38.68 10.24 78 152947 8177 53187864
Urticaria 38.01 10.24 231 152794 135654 53060387
Conjoined twins 37.94 10.24 18 153007 276 53195765
Reversible airways obstruction 37.48 10.24 29 152996 1115 53194926
Memory impairment 37.04 10.24 122 152903 84635 53111406
Blood creatinine increased 36.88 10.24 381 152644 82281 53113760
Basilar artery occlusion 36.22 10.24 14 153011 125 53195916
Thrombosis 36.13 10.24 75 152950 60718 53135323
Palpitations 35.43 10.24 449 152576 101899 53094142
Lyme disease 35.36 10.24 41 152984 2636 53193405
Stomatitis 35.30 10.24 153 152872 98005 53098036
N-terminal prohormone brain natriuretic peptide abnormal 35.27 10.24 11 153014 47 53195994
Clostridium difficile infection 35.17 10.24 18 153007 27875 53168166
Chills 34.98 10.24 168 152857 104680 53091361
Bundle branch block left 34.95 10.24 68 152957 6945 53189096
Respiratory arrest 34.91 10.24 27 152998 33513 53162528
Pancytopenia 34.56 10.24 406 152619 90522 53105519
Epileptic encephalopathy 34.53 10.24 17 153008 284 53195757
Hypertension 34.35 10.24 868 152157 224563 52971478
Full blood count decreased 34.25 10.24 13 153012 24016 53172025
Atrial thrombosis 34.19 10.24 31 152994 1488 53194553
Blood creatine phosphokinase increased 34.05 10.24 169 152856 28816 53167225
Dizziness 33.94 10.24 1347 151678 370912 52825129
Blood pressure increased 33.94 10.24 579 152446 139900 53056141
Ill-defined disorder 33.81 10.24 56 152969 49388 53146653
Dermatitis bullous 33.43 10.24 73 152952 8090 53187951
Irritability 33.40 10.24 24 153001 30929 53165112
Platelet count decreased 33.33 10.24 178 152847 107921 53088120
Inappropriate antidiuretic hormone secretion 32.82 10.24 106 152919 14845 53181196
Pemphigoid 32.74 10.24 63 152962 6381 53189660
Gravitational oedema 32.67 10.24 28 152997 1246 53194795
Fungal infection 32.26 10.24 27 152998 32219 53163822
Therapy interrupted 32.23 10.24 8 153017 19428 53176613
Delirium 31.94 10.24 216 152809 41213 53154828
Hepatitis 31.92 10.24 186 152839 33708 53162333
Hyperthyroidism 31.76 10.24 96 152929 12977 53183064
Skin weeping 31.74 10.24 17 153008 341 53195700
Abnormal loss of weight 31.68 10.24 56 152969 5316 53190725
Abdominal wall haematoma 31.64 10.24 41 152984 2957 53193084
Vascular purpura 31.63 10.24 29 152996 1412 53194629
Herpes zoster 31.35 10.24 108 152917 73911 53122130
Eczema 31.30 10.24 145 152880 24037 53172004
Psychomotor retardation 31.21 10.24 45 152980 3593 53192448
C-reactive protein abnormal 30.72 10.24 18 153007 25852 53170189
Multiple sclerosis 30.71 10.24 20 153005 27133 53168908
Heart rate decreased 30.52 10.24 196 152829 36751 53159290
Tachycardia paroxysmal 30.51 10.24 16 153009 307 53195734
Illness 30.48 10.24 13 153012 22383 53173658
Aortic arteriosclerosis 30.27 10.24 58 152967 5856 53190185
Dyspnoea exertional 30.24 10.24 265 152760 54735 53141306
Drug monitoring procedure not performed 30.21 10.24 19 153006 520 53195521
Hepatitis acute 30.21 10.24 74 152951 8842 53187199
Orthopnoea 30.19 10.24 59 152966 6045 53189996
Injury 30.19 10.24 63 152962 50908 53145133
Loss of personal independence in daily activities 30.16 10.24 101 152924 69714 53126327
Paresis 30.14 10.24 35 152990 2254 53193787
Wrong technique in product usage process 30.13 10.24 81 152944 59951 53136090
Blood pressure decreased 29.93 10.24 290 152735 61579 53134462
Retroperitoneal haematoma 29.90 10.24 39 152986 2831 53193210
Seizure 29.86 10.24 233 152792 129276 53066765
Urine output decreased 29.80 10.24 87 152938 11536 53184505
Impaired healing 29.75 10.24 90 152935 64115 53131926
Restlessness 29.00 10.24 158 152867 27929 53168112
Sputum culture positive 28.80 10.24 28 152997 1469 53194572
Diabetic metabolic decompensation 28.63 10.24 29 152996 1599 53194442
Nocturia 28.63 10.24 66 152959 7584 53188457
Arterial haemorrhage 28.29 10.24 30 152995 1746 53194295
Faeces discoloured 28.24 10.24 113 152912 17573 53178468
Nasal congestion 28.20 10.24 70 152955 53217 53142824
Subcutaneous haematoma 28.19 10.24 29 152996 1629 53194412
Congenital bladder anomaly 28.08 10.24 13 153012 188 53195853
Urachal abnormality 27.84 10.24 13 153012 192 53195849
Gastrooesophageal reflux disease 27.83 10.24 132 152893 82531 53113510
Femoral hernia incarcerated 27.46 10.24 22 153003 890 53195151
Bicytopenia 27.46 10.24 32 152993 2069 53193972
Gastrointestinal disorder 27.31 10.24 149 152876 89855 53106186
Sight disability 27.28 10.24 11 153014 111 53195930
Hepatic enzyme increased 27.28 10.24 231 152794 125964 53070077
Thermohypoaesthesia 27.19 10.24 11 153014 112 53195929
Spontaneous haematoma 27.17 10.24 21 153004 806 53195235
Hypersensitivity vasculitis 27.09 10.24 47 152978 4396 53191645
Surgery 27.08 10.24 31 152994 31933 53164108
Multiple organ dysfunction syndrome 26.94 10.24 261 152764 55416 53140625
Spontaneous haemorrhage 26.82 10.24 14 153011 266 53195775
Persistent cloaca 26.79 10.24 13 153012 210 53195831
Nephrolithiasis 26.66 10.24 40 152985 36707 53159334
Blood pressure systolic decreased 26.60 10.24 55 152970 5869 53190172
Bronchial secretion retention 26.57 10.24 28 152997 1618 53194423
Androgenetic alopecia 26.53 10.24 12 153013 164 53195877
Oliguria 26.48 10.24 72 152953 9166 53186875
Cardiovascular disorder 26.34 10.24 87 152938 12326 53183715
Bursitis 26.21 10.24 16 153009 22476 53173565
Toxic skin eruption 26.04 10.24 90 152935 13049 53182992
Potentiating drug interaction 25.94 10.24 45 152980 4208 53191833
Pancreatic steatosis 25.86 10.24 23 153002 1076 53194965
Neck pain 25.80 10.24 87 152938 59929 53136112
Lymphatic fistula 25.64 10.24 21 153004 877 53195164
Neutrophil count decreased 25.59 10.24 65 152960 49033 53147008
Oropharyngeal pain 25.51 10.24 133 152892 81135 53114906
Night sweats 25.39 10.24 38 152987 34909 53161132
Injection site haemorrhage 25.27 10.24 16 153009 22035 53174006
Altered state of consciousness 25.17 10.24 139 152886 24697 53171344
Diverticulum intestinal 25.01 10.24 57 152968 6500 53189541
Peripheral circulatory failure 24.92 10.24 15 153010 379 53195662
Skin haemorrhage 24.90 10.24 58 152967 6709 53189332
Product monitoring error 24.90 10.24 36 152989 2881 53193160
Intentional product use issue 24.85 10.24 115 152910 72379 53123662
Premature delivery 24.74 10.24 23 153002 26081 53169960
Drug level increased 24.65 10.24 120 152905 20301 53175740
Cardiac tamponade 24.65 10.24 46 152979 4554 53191487
Bundle branch block right 24.64 10.24 49 152976 5084 53190957
Tricuspid valve incompetence 24.63 10.24 94 152931 14302 53181739
Intestinal malrotation 24.43 10.24 15 153010 393 53195648
Jaundice cholestatic 24.40 10.24 51 152974 5483 53190558
Tooth disorder 24.35 10.24 22 153003 25290 53170751
Complication associated with device 24.32 10.24 8 153017 16157 53179884
Anaemia macrocytic 24.30 10.24 35 152990 2791 53193250
Haemorrhagic diathesis 24.27 10.24 45 152980 4433 53191608
Myositis 24.20 10.24 66 152959 8417 53187624
Anal haemorrhage 24.14 10.24 27 152998 1669 53194372
Gallbladder disorder 24.00 10.24 11 153014 18154 53177887
Polycythaemia 23.86 10.24 20 153005 863 53195178
Ear pain 23.84 10.24 30 152995 29643 53166398
Laboratory test abnormal 23.73 10.24 21 153004 24388 53171653
Device malfunction 23.71 10.24 8 153017 15900 53180141
Infusion site pain 23.67 10.24 3 153022 11830 53184211
Serum procollagen type I N-terminal propeptide increased 23.65 10.24 7 153018 24 53196017
Blood loss anaemia 23.54 10.24 67 152958 8756 53187285
Neuropathy, ataxia, retinitis pigmentosa syndrome 23.43 10.24 8 153017 48 53195993
Embolic cerebral infarction 23.40 10.24 16 153009 506 53195535
Fracture 23.29 10.24 108 152917 17911 53178130
Interstitial lung disease 23.27 10.24 264 152761 58358 53137683
Osteoporosis 23.08 10.24 63 152962 46397 53149644
Disability 23.08 10.24 4 153021 12494 53183547
Injection site warmth 23.07 10.24 6 153019 14122 53181919
Hypereosinophilic syndrome 22.96 10.24 13 153012 292 53195749
Acne 22.95 10.24 17 153008 21569 53174472
Long QT syndrome 22.94 10.24 37 152988 3259 53192782
Pustule 22.76 10.24 22 153003 1146 53194895
Influenza 22.73 10.24 170 152855 95209 53100832
Lower gastrointestinal haemorrhage 22.72 10.24 60 152965 7506 53188535
Emotional distress 22.66 10.24 36 152989 32281 53163760
Petechiae 22.59 10.24 88 152937 13517 53182524
Metabolic alkalosis 22.55 10.24 35 152990 2984 53193057
Obstructive pancreatitis 22.48 10.24 12 153013 239 53195802
Intestinal transit time abnormal 22.39 10.24 9 153016 90 53195951
Infective exacerbation of chronic obstructive airways disease 22.28 10.24 23 153002 1297 53194744
Aphasia 22.26 10.24 158 152867 30620 53165421
Purpura 22.08 10.24 75 152950 10778 53185263
Ear infection 22.07 10.24 25 153000 25875 53170166
Dermatitis exfoliative 21.98 10.24 51 152974 5885 53190156
Aortic valve stenosis 21.66 10.24 36 152989 3252 53192789
Thrombocytopenia 21.65 10.24 536 152489 138191 53057850
Erythrodermic psoriasis 21.54 10.24 20 153005 990 53195051
Neovascular age-related macular degeneration 21.51 10.24 11 153014 200 53195841
Product administration error 21.48 10.24 120 152905 21411 53174630
Retinal artery occlusion 21.43 10.24 25 153000 1618 53194423
Grip strength decreased 21.18 10.24 4 153021 11745 53184296
Rash maculo-papular 21.10 10.24 152 152873 29597 53166444
Musculoskeletal disorder 21.03 10.24 12 153013 17487 53178554
Blister 20.91 10.24 136 152889 78617 53117424
Electrocardiogram abnormal 20.87 10.24 61 152964 8092 53187949
Tetany 20.71 10.24 26 152999 1817 53194224
Joint range of motion decreased 20.61 10.24 13 153012 17943 53178098
Foot fracture 20.58 10.24 18 153007 21021 53175020
Vascular encephalopathy 20.52 10.24 14 153011 441 53195600
Sinoatrial block 20.48 10.24 18 153007 829 53195212
Intestinal haemorrhage 20.46 10.24 36 152989 3404 53192637
Pain in jaw 20.31 10.24 55 152970 40614 53155427
Therapeutic product effect incomplete 20.28 10.24 167 152858 91617 53104424
Hallucination 20.27 10.24 240 152785 53598 53142443
Osteoarthritis 20.13 10.24 119 152906 70367 53125674
Ventricular arrhythmia 20.11 10.24 37 152988 3623 53192418
Hypertransaminasaemia 20.08 10.24 39 152986 3977 53192064
Inappropriate schedule of product administration 20.04 10.24 129 152896 74749 53121292
Musculoskeletal discomfort 19.90 10.24 10 153015 15650 53180391
Subacute cutaneous lupus erythematosus 19.89 10.24 29 152996 2339 53193702
Respiratory tract infection 19.80 10.24 163 152862 33061 53162980
Haematocrit decreased 19.79 10.24 49 152976 37282 53158759
Sudden hearing loss 19.68 10.24 21 153004 1231 53194810
Vomiting 19.66 10.24 1668 151357 495471 52700570
Dyspnoea at rest 19.61 10.24 38 152987 3869 53192172
Mood swings 19.61 10.24 13 153012 17473 53178568
Hypochloraemia 19.59 10.24 26 152999 1920 53194121
Suicidal ideation 19.57 10.24 98 152927 60413 53135628
Thiopurine methyltransferase decreased 19.56 10.24 12 153013 314 53195727
Contusion 19.55 10.24 213 152812 110519 53085522
Atelectasis 19.55 10.24 17 153008 19909 53176132
Road traffic accident 19.48 10.24 27 152998 25604 53170437
Bone density decreased 19.45 10.24 4 153021 11060 53184981
Rheumatoid nodule 19.44 10.24 5 153020 11859 53184182
Procollagen type I C-terminal propeptide increased 19.36 10.24 6 153019 25 53196016
Muscle haemorrhage 19.31 10.24 35 152990 3388 53192653
Shock 19.26 10.24 123 152902 23016 53173025
Disease recurrence 19.21 10.24 19 153006 20927 53175114
Joint stiffness 19.16 10.24 36 152989 30247 53165794
Hypertensive angiopathy 19.15 10.24 8 153017 89 53195952
Exercise tolerance decreased 19.07 10.24 45 152980 5250 53190791
Immune thrombocytopenia 19.01 10.24 65 152960 9373 53186668
Accidental exposure to product 18.95 10.24 24 153001 23650 53172391
Aortic dissection 18.90 10.24 24 153001 1696 53194345
Small intestinal obstruction 18.89 10.24 13 153012 17134 53178907
Small cell carcinoma 18.79 10.24 10 153015 198 53195843
Pulmonary oedema 18.71 10.24 236 152789 53487 53142554
Transcription medication error 18.67 10.24 11 153014 267 53195774
Lethargy 18.66 10.24 236 152789 53524 53142517
Emotional disorder 18.65 10.24 7 153018 13023 53183018
Cerebral haematoma 18.65 10.24 35 152990 3479 53192562
Deprescribing error 18.64 10.24 6 153019 29 53196012
Hepatorenal failure 18.62 10.24 15 153010 612 53195429
Wound infection pseudomonas 18.60 10.24 22 153003 1445 53194596
Overdose 18.55 10.24 422 152603 107314 53088727
Language disorder 18.42 10.24 25 153000 1886 53194155
Multimorbidity 18.39 10.24 16 153009 727 53195314
Pancreatitis acute 18.29 10.24 133 152892 25976 53170065
Back disorder 18.23 10.24 3 153022 9732 53186309
Blood cholesterol increased 18.19 10.24 84 152941 52905 53143136
Cerebrovascular accident 18.12 10.24 412 152613 104762 53091279
Peripheral arterial occlusive disease 18.09 10.24 37 152988 3917 53192124
Coma 18.07 10.24 263 152762 61520 53134521
Blood pressure systolic increased 18.06 10.24 167 152858 35010 53161031
Hepatocellular carcinoma 18.02 10.24 32 152993 3048 53192993
Enanthema 18.01 10.24 13 153012 449 53195592
Pyroglutamic acidosis 17.93 10.24 12 153013 366 53195675
First trimester pregnancy 17.92 10.24 5 153020 13 53196028
Administration site discomfort 17.84 10.24 8 153017 107 53195934
Mucosal dryness 17.61 10.24 29 152996 2599 53193442
Defect conduction intraventricular 17.58 10.24 8 153017 111 53195930
Psychogenic visual disorder 17.40 10.24 5 153020 15 53196026
Lupus nephritis 17.32 10.24 28 152997 2471 53193570
Drug resistance 17.30 10.24 19 153006 19943 53176098
Bladder sphincter atony 17.29 10.24 9 153016 170 53195871
Infective spondylitis 17.29 10.24 9 153016 170 53195871
Periorbital haematoma 17.28 10.24 16 153009 789 53195252
Stress cardiomyopathy 17.27 10.24 59 152966 8503 53187538
Renal artery stenosis 17.27 10.24 24 153001 1852 53194189
Renal aplasia 17.22 10.24 10 153015 236 53195805
Live birth 17.15 10.24 11 153014 15048 53180993
Premature labour 17.10 10.24 7 153018 12355 53183686
Walking disability 17.08 10.24 21 153004 1436 53194605
Subileus 17.03 10.24 32 152993 3184 53192857
Chondrocalcinosis 17.03 10.24 14 153011 588 53195453
Orthostatic intolerance 16.99 10.24 19 153006 1174 53194867
Device dislocation 16.82 10.24 26 152999 23571 53172470
Hyporesponsive to stimuli 16.72 10.24 18 153007 1066 53194975
Lower limb fracture 16.70 10.24 10 153015 14195 53181846
Vitamin B12 decreased 16.67 10.24 31 152994 3061 53192980
Anal polyp 16.66 10.24 6 153019 43 53195998
Gastric pH increased 16.66 10.24 6 153019 43 53195998
Anhedonia 16.59 10.24 5 153020 10682 53185359
Extrasystoles 16.58 10.24 42 152983 5124 53190917
Fluid retention 16.53 10.24 90 152935 54311 53141730
Ventricular hypokinesia 16.44 10.24 38 152987 4374 53191667
Chest injury 16.43 10.24 21 153004 1494 53194547
Oral herpes 16.41 10.24 22 153003 21157 53174884
Retrograde amnesia 16.39 10.24 12 153013 424 53195617
Eastern Cooperative Oncology Group performance status worsened 16.36 10.24 14 153011 622 53195419
Red blood cell sedimentation rate increased 16.34 10.24 35 152990 28022 53168019
Muscle spasms 16.32 10.24 280 152745 134515 53061526
Prothrombin time shortened 16.29 10.24 23 153002 1801 53194240
Therapy non-responder 16.20 10.24 79 152946 49041 53147000
Gonorrhoea 16.12 10.24 8 153017 136 53195905
Coronary artery stenosis 16.11 10.24 40 152985 4819 53191222
Sinus arrest 16.10 10.24 23 153002 1821 53194220
Spinal disorder 16.02 10.24 3 153022 8861 53187180
Ventricular internal diameter abnormal 15.99 10.24 6 153019 49 53195992
Ligament sprain 15.98 10.24 6 153019 11160 53184881
Peripheral embolism 15.85 10.24 19 153006 1266 53194775
Extensor plantar response 15.85 10.24 19 153006 1266 53194775
Hip fracture 15.84 10.24 36 152989 28221 53167820
Tenderness 15.79 10.24 20 153005 19710 53176331
Ventricular tachycardia 15.78 10.24 96 152929 17666 53178375
Duodenal ulcer 15.74 10.24 53 152972 7583 53188458
Rash scarlatiniform 15.71 10.24 8 153017 144 53195897
Cataract 15.68 10.24 81 152944 49539 53146502
Vascular stenosis 15.67 10.24 10 153015 281 53195760
Genital candidiasis 15.58 10.24 7 153018 94 53195947
Eye disorder 15.58 10.24 20 153005 19594 53176447
Left atrial enlargement 15.54 10.24 10 153015 285 53195756
Neurologic neglect syndrome 15.53 10.24 18 153007 1157 53194884
Connective tissue inflammation 15.48 10.24 6 153019 54 53195987
Staphylococcal scalded skin syndrome 15.42 10.24 8 153017 150 53195891
Tuberculosis of central nervous system 15.39 10.24 11 153014 374 53195667
Hypokinesia 15.33 10.24 76 152949 12951 53183090
Ketoacidosis 15.28 10.24 37 152988 4389 53191652
Platelet aggregation decreased 15.24 10.24 5 153020 26 53196015
Cardiac valve sclerosis 15.24 10.24 5 153020 26 53196015
Blood potassium decreased 15.20 10.24 62 152963 40398 53155643
Fear of eating 15.19 10.24 11 153014 382 53195659
Red cell distribution width abnormal 15.19 10.24 8 153017 155 53195886
Myocardial ischaemia 15.16 10.24 75 152950 12769 53183272
Ocular icterus 15.11 10.24 34 152991 3845 53192196
Hepatitis toxic 15.10 10.24 30 152995 3111 53192930
Gastroenteritis viral 15.08 10.24 20 153005 19325 53176716
Gastrointestinal sounds abnormal 15.08 10.24 34 152991 3850 53192191
Pneumonia 15.08 10.24 986 152039 406183 52789858
Normochromic normocytic anaemia 15.04 10.24 38 152987 4628 53191413
Atrial tachycardia 15.03 10.24 25 153000 2259 53193782
Ventricular extrasystoles 14.95 10.24 70 152955 11654 53184387
Feeling jittery 14.93 10.24 8 153017 12075 53183966
Eyelid retraction 14.84 10.24 6 153019 61 53195980
Optic ischaemic neuropathy 14.84 10.24 17 153008 1079 53194962
Pleurothotonus 14.77 10.24 19 153006 1360 53194681
Prohormone brain natriuretic peptide increased 14.74 10.24 8 153017 165 53195876
Peripheral artery haematoma 14.67 10.24 6 153019 63 53195978
Nodule 14.66 10.24 17 153008 17412 53178629
Parkinsonian rest tremor 14.66 10.24 7 153018 109 53195932
Device breakage 14.59 10.24 6 153019 10561 53185480
Spinal ligament ossification 14.57 10.24 3 153022 0 53196041
Paranasal sinus haematoma 14.57 10.24 3 153022 0 53196041
Cerebral artery occlusion 14.53 10.24 16 153009 972 53195069
Acidosis 14.51 10.24 68 152957 11324 53184717
Hypercreatininaemia 14.46 10.24 11 153014 412 53195629
Chronic kidney disease 14.46 10.24 189 152836 43181 53152860
Skin discolouration 14.46 10.24 52 152973 35140 53160901
Hepatitis cholestatic 14.39 10.24 49 152976 7050 53188991
Genital infection female 14.38 10.24 7 153018 114 53195927
Ventricular dyssynchrony 14.37 10.24 5 153020 32 53196009
Angioedema 14.30 10.24 184 152841 41892 53154149
Nephrosclerosis 14.28 10.24 16 153009 991 53195050
Urinary straining 14.24 10.24 5 153020 33 53196008
Peripheral sensory neuropathy 14.20 10.24 49 152976 7099 53188942
Blood aldosterone increased 14.20 10.24 8 153017 178 53195863
Lower respiratory tract infection 14.13 10.24 180 152845 90801 53105240
Wrong dose 14.09 10.24 15 153010 877 53195164
Neoplasm malignant 14.04 10.24 33 152992 25568 53170473
Superinfection 14.00 10.24 24 153001 2223 53193818
Sleep disorder 13.99 10.24 105 152920 58765 53137276
Nodal rhythm 13.98 10.24 21 153004 1739 53194302
Amaurosis 13.96 10.24 12 153013 536 53195505
Brain stem haemorrhage 13.93 10.24 14 153011 765 53195276
Retroperitoneal fibrosis 13.89 10.24 10 153015 344 53195697
Sleep apnoea syndrome 13.88 10.24 34 152991 25968 53170073
Anaphylactic reaction 13.87 10.24 104 152921 58222 53137819
Seasonal allergy 13.86 10.24 14 153011 15271 53180770
Bacterial infection 13.83 10.24 18 153007 17529 53178512
Bifascicular block 13.75 10.24 7 153018 126 53195915
Femoral neck fracture 13.74 10.24 54 152971 8329 53187712
Myoglobin blood increased 13.72 10.24 19 153006 1461 53194580
Small for dates baby 13.63 10.24 32 152993 3720 53192321
Abortion induced 13.63 10.24 7 153018 10819 53185222
Haemorrhagic transformation stroke 13.62 10.24 17 153008 1181 53194860
Bone disorder 13.61 10.24 24 153001 20659 53175382
Pharyngeal haemorrhage 13.59 10.24 12 153013 556 53195485
Subdural haemorrhage 13.57 10.24 28 152997 2984 53193057
Photophobia 13.52 10.24 16 153009 16242 53179799
Hypoglycaemic coma 13.52 10.24 26 152999 2632 53193409
Cardiac failure congestive 13.50 10.24 186 152839 92571 53103470
Exostosis 13.49 10.24 8 153017 11416 53184625
Haematoma muscle 13.45 10.24 13 153012 677 53195364
Femur fracture 13.44 10.24 63 152962 39522 53156519
Head injury 13.44 10.24 123 152902 25710 53170331
Altered visual depth perception 13.42 10.24 10 153015 363 53195678
Behaviour disorder 13.39 10.24 25 153000 2475 53193566
Kussmaul respiration 13.36 10.24 8 153017 200 53195841
Febrile neutropenia 13.35 10.24 216 152809 104720 53091321
Seroma 13.33 10.24 23 153002 2142 53193899
Rhinitis allergic 13.28 10.24 3 153022 7770 53188271
Blindness cortical 13.28 10.24 11 153014 467 53195574
Wrong drug 13.27 10.24 7 153018 136 53195905
Laryngitis 13.25 10.24 7 153018 10648 53185393
Carotid artery thrombosis 13.24 10.24 17 153008 1215 53194826
Ecchymosis 13.24 10.24 65 152960 11034 53185007
Phrenic nerve paralysis 13.20 10.24 5 153020 42 53195999
Skin dystrophy 13.20 10.24 5 153020 42 53195999
Brain contusion 13.18 10.24 12 153013 579 53195462
Drug dependence 13.17 10.24 26 152999 21446 53174595
Hypernatraemia 13.07 10.24 47 152978 6950 53189091
Bipolar disorder 13.06 10.24 3 153022 7683 53188358
Sinus rhythm 12.95 10.24 13 153012 709 53195332
Myocardial infarction 12.95 10.24 375 152650 98979 53097062
Glomerular filtration rate abnormal 12.94 10.24 12 153013 593 53195448
Bullous haemorrhagic dermatosis 12.90 10.24 5 153020 45 53195996
Rotator cuff syndrome 12.89 10.24 10 153015 12395 53183646
Cholecystectomy 12.88 10.24 6 153019 9809 53186232
Cardioactive drug level above therapeutic 12.87 10.24 7 153018 145 53195896
Agitation 12.85 10.24 238 152787 58388 53137653
Dilatation ventricular 12.84 10.24 25 153000 2554 53193487
Mucosal membrane hyperplasia 12.80 10.24 5 153020 46 53195995
Inflammatory marker increased 12.79 10.24 43 152982 6147 53189894
Crying 12.78 10.24 28 152997 22234 53173807
Candida infection 12.76 10.24 34 152991 25239 53170802
Paroxysmal arrhythmia 12.71 10.24 5 153020 47 53195994
Nerve compression 12.69 10.24 3 153022 7533 53188508
Renal cyst ruptured 12.66 10.24 4 153021 18 53196023
Monoparesis 12.64 10.24 19 153006 1575 53194466
Tooth abscess 12.58 10.24 12 153013 13446 53182595
External ear disorder 12.53 10.24 5 153020 49 53195992
Gastric atony 12.50 10.24 3 153022 3 53196038
Cardiac valve fibroelastoma 12.50 10.24 3 153022 3 53196038
Blood lactate dehydrogenase 12.50 10.24 3 153022 3 53196038
Caesarean section 12.42 10.24 19 153006 17301 53178740
Lip swelling 12.42 10.24 126 152899 27075 53168966
Angiodermatitis 12.36 10.24 6 153019 97 53195944
Compensatory sweating 12.32 10.24 4 153021 20 53196021
Mood altered 12.31 10.24 13 153012 13888 53182153
Malaise 12.29 10.24 1188 151837 356429 52839612
Peripheral ischaemia 12.28 10.24 36 152989 4783 53191258
Angiocardiogram 12.27 10.24 5 153020 52 53195989
Intentional product misuse 12.26 10.24 87 152938 49305 53146736
Giant cell arteritis 12.23 10.24 21 153004 1948 53194093
Degenerative mitral valve disease 12.16 10.24 4 153021 21 53196020
Blood calcium decreased 12.11 10.24 24 153001 19770 53176271
Acute generalised exanthematous pustulosis 12.11 10.24 60 152965 10221 53185820
Epilepsy 12.08 10.24 120 152905 25647 53170394
Systolic hypertension 12.04 10.24 10 153015 426 53195615
Blood glucose increased 12.03 10.24 153 152872 77208 53118833
Tachycardia induced cardiomyopathy 12.02 10.24 5 153020 55 53195986
Wrong strength 11.94 10.24 5 153020 56 53195985
Cystitis bacterial 11.94 10.24 5 153020 56 53195985
Serratia infection 11.90 10.24 14 153011 914 53195127
Face oedema 11.90 10.24 99 152926 20141 53175900
Thirst 11.90 10.24 65 152960 11501 53184540
Deformity 11.85 10.24 4 153021 7950 53188091
Intra-abdominal haematoma 11.84 10.24 19 153006 1666 53194375
Peripartum cardiomyopathy 11.80 10.24 7 153018 172 53195869
Leukopenia 11.80 10.24 285 152740 73178 53122863
Chronic cutaneous lupus erythematosus 11.77 10.24 7 153018 173 53195868
Drug-induced liver injury 11.76 10.24 132 152893 29101 53166940
Dystonia 11.73 10.24 12 153013 13009 53183032
Paraparesis 11.72 10.24 22 153003 2188 53193853
Mania 11.72 10.24 10 153015 11819 53184222
Product substitution error 11.71 10.24 4 153021 24 53196017
Hypoacusis 11.71 10.24 30 152995 22569 53173472
Gamma-glutamyltransferase abnormal 11.65 10.24 8 153017 255 53195786
Pharyngitis 11.63 10.24 23 153002 18957 53177084
Eye irritation 11.61 10.24 22 153003 18427 53177614
Renal injury 11.60 10.24 7 153018 9897 53186144
Eructation 11.60 10.24 49 152976 7806 53188235
Hysterectomy 11.60 10.24 5 153020 8556 53187485
Troponin I increased 11.59 10.24 21 153004 2032 53194009
Dysarthria 11.59 10.24 172 152853 40396 53155645
Ventricular dysfunction 11.57 10.24 26 152999 2937 53193104
Drug therapeutic incompatibility 11.56 10.24 5 153020 61 53195980
Body height decreased 11.55 10.24 7 153018 9872 53186169
Phaeochromocytoma 11.54 10.24 11 153014 563 53195478
Muscular weakness 11.51 10.24 375 152650 100617 53095424
Hepatic cyst 11.49 10.24 36 152989 4960 53191081
Cardiovascular insufficiency 11.49 10.24 17 153008 1389 53194652
Pyrexia 11.48 10.24 998 152027 402195 52793846
Immune-mediated enterocolitis 11.47 10.24 14 153011 950 53195091
Hyperglycaemia 11.47 10.24 170 152855 39914 53156127
Product used for unknown indication 11.46 10.24 12 153013 688 53195353
Chest wall mass 11.42 10.24 5 153020 63 53195978
Product complaint 11.38 10.24 11 153014 12246 53183795
Normochromic anaemia 11.38 10.24 8 153017 265 53195776
Discoloured vomit 11.36 10.24 12 153013 695 53195346
Failure to thrive 11.36 10.24 3 153022 6989 53189052
Supraventricular extrasystoles 11.34 10.24 33 152992 4367 53191674
Respiratory depression 11.31 10.24 12 153013 12794 53183247
Gait inability 11.30 10.24 64 152961 38247 53157794
Urosepsis 11.28 10.24 84 152941 16526 53179515
Hepatitis fulminant 11.18 10.24 29 152996 3590 53192451
Parapsoriasis 11.17 10.24 6 153019 121 53195920
Influenza like illness 11.17 10.24 116 152909 60743 53135298
Drug ineffective for unapproved indication 11.13 10.24 27 152998 20693 53175348
Chorea 11.12 10.24 17 153008 1430 53194611
Cerebellar infarction 11.11 10.24 20 153005 1926 53194115
Scar 11.09 10.24 12 153013 12681 53183360
Polydipsia 11.07 10.24 28 152997 3412 53192629
Cerebellar haemorrhage 11.05 10.24 17 153008 1438 53194603
Electrocardiogram QT shortened 11.04 10.24 6 153019 124 53195917
Peritoneal perforation 11.04 10.24 6 153019 124 53195917
Vulval cancer 11.03 10.24 12 153013 719 53195322
Cerebral artery embolism 11.01 10.24 13 153012 852 53195189
Ulcer 10.98 10.24 27 152998 20592 53175449
Limb discomfort 10.96 10.24 37 152988 25485 53170556
Cerebral ventricular rupture 10.96 10.24 7 153018 197 53195844
Joint injury 10.95 10.24 30 152995 22070 53173971
Glaucoma 10.95 10.24 20 153005 16983 53179058
Ischaemic cerebral infarction 10.94 10.24 16 153009 1294 53194747
Cystitis noninfective 10.92 10.24 13 153012 860 53195181
Nodal arrhythmia 10.90 10.24 16 153009 1298 53194743
Resuscitation 10.88 10.24 15 153010 1149 53194892
Coma acidotic 10.87 10.24 6 153019 128 53195913
Faecal volume decreased 10.86 10.24 7 153018 200 53195841
Sudden death 10.82 10.24 58 152967 10190 53185851
Gastritis erosive 10.76 10.24 38 152987 5568 53190473
Trifascicular block 10.75 10.24 6 153019 131 53195910
Ovarian cyst 10.71 10.24 17 153008 15252 53180789
Diffuse alopecia 10.71 10.24 11 153014 617 53195424
Body temperature decreased 10.68 10.24 83 152942 16544 53179497
Antipsychotic drug level above therapeutic 10.67 10.24 14 153011 1022 53195019
Iron deficiency 10.66 10.24 41 152984 6259 53189782
Nerve injury 10.66 10.24 6 153019 8809 53187232
Supraventricular tachycardia 10.63 10.24 74 152951 14251 53181790
Viral infection 10.61 10.24 52 152973 32243 53163798
Pruritus 10.61 10.24 713 152312 293119 52902922
Muscle spasticity 10.60 10.24 22 153003 17816 53178225
Hyperleukocytosis 10.59 10.24 10 153015 506 53195535
Gastric ulcer 10.55 10.24 108 152917 23261 53172780
Thalamus haemorrhage 10.55 10.24 11 153014 628 53195413
Skin turgor decreased 10.50 10.24 10 153015 511 53195530
Injection site mass 10.50 10.24 19 153006 16195 53179846
Tardive dyskinesia 10.49 10.24 5 153020 8065 53187976
Liver function test abnormal 10.48 10.24 195 152830 47876 53148165
Pericardial effusion 10.44 10.24 122 152903 27156 53168885
Drug metabolising enzyme decreased 10.44 10.24 3 153022 9 53196032
Cheyne-Stokes respiration 10.43 10.24 6 153019 139 53195902
Throat irritation 10.42 10.24 51 152974 31630 53164411
Secondary hypertension 10.39 10.24 6 153019 140 53195901
Respiratory acidosis 10.35 10.24 41 152984 6347 53189694
Electrocardiogram ST segment elevation 10.33 10.24 29 152996 3760 53192281
Cerebellar ischaemia 10.32 10.24 4 153021 36 53196005
Angiotensin converting enzyme inhibitor foetopathy 10.32 10.24 4 153021 36 53196005
Injection site induration 10.31 10.24 6 153019 8652 53187389
Brief psychotic disorder with marked stressors 10.29 10.24 5 153020 81 53195960
Pre-eclampsia 10.29 10.24 6 153019 8641 53187400
Compartment syndrome 10.29 10.24 20 153005 2041 53194000
Brain injury 10.29 10.24 41 152984 6364 53189677
Haemorrhagic infarction 10.28 10.24 8 153017 310 53195731
Hyperglycaemic hyperosmolar nonketotic syndrome 10.28 10.24 11 153014 647 53195394
Mediastinitis 10.28 10.24 7 153018 220 53195821
Myelosuppression 10.27 10.24 13 153012 12815 53183226
Necrotising fasciitis 10.27 10.24 24 153001 2783 53193258

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 766.58 10.94 3089 151864 290379 32068194
Bradycardia 710.80 10.94 1245 153708 70317 32288256
Cardiac failure 620.58 10.94 1357 153596 90316 32268257
Hyperkalaemia 445.22 10.94 1009 153944 68741 32289832
Death 444.68 10.94 713 154240 381804 31976769
Drug interaction 419.54 10.94 2100 152853 216085 32142488
Atrial fibrillation 295.14 10.94 1219 153734 115485 32243088
Melaena 255.79 10.94 532 154421 34133 32324440
Completed suicide 251.93 10.94 65 154888 92452 32266121
Lactic acidosis 231.61 10.94 501 154452 33035 32325538
Drug ineffective 229.87 10.94 995 153958 382482 31976091
General physical health deterioration 207.21 10.94 1090 153863 114169 32244404
Hypotension 198.75 10.94 1730 153223 214380 32144193
Syncope 194.52 10.94 898 154055 89226 32269347
Product dose omission issue 192.45 10.94 126 154827 102449 32256124
Ischaemic stroke 171.79 10.94 304 154649 17272 32341301
Cardiac failure chronic 160.24 10.94 185 154768 7055 32351518
Haematuria 153.12 10.94 543 154410 47818 32310755
Dyspnoea 151.06 10.94 2491 152462 359554 31999019
Labelled drug-drug interaction medication error 141.56 10.94 230 154723 12183 32346390
Cerebral haemorrhage 141.39 10.94 425 154528 34322 32324251
Sinus bradycardia 138.51 10.94 233 154720 12705 32345868
Rectal haemorrhage 137.72 10.94 442 154511 36981 32321592
International normalised ratio increased 136.34 10.94 528 154425 48507 32310066
Angina pectoris 131.29 10.94 388 154565 31038 32327535
N-terminal prohormone brain natriuretic peptide increased 129.35 10.94 94 154859 1938 32356635
Shock haemorrhagic 129.30 10.94 203 154750 10442 32348131
Orthostatic hypotension 124.10 10.94 334 154619 25316 32333257
White blood cell count decreased 119.04 10.94 156 154797 91042 32267531
Disease progression 116.04 10.94 146 154807 86716 32271857
Arrhythmia 113.10 10.94 398 154555 34905 32323668
Left ventricular dysfunction 111.04 10.94 180 154773 9515 32349058
Toxicity to various agents 109.22 10.94 457 154496 177584 32180989
Presyncope 107.64 10.94 248 154705 17053 32341520
Neuropathy peripheral 107.48 10.94 125 154828 76857 32281716
Mental status changes 106.09 10.94 26 154927 38311 32320262
Hospitalisation 104.93 10.94 51 154902 48920 32309653
Febrile neutropenia 103.01 10.94 264 154689 119302 32239271
Ventricular tachycardia 101.52 10.94 310 154643 25246 32333327
Pain 101.00 10.94 505 154448 187051 32171522
Atrioventricular block 97.18 10.94 149 154804 7506 32351067
Unevaluable event 96.48 10.94 21 154932 33565 32325008
Rhabdomyolysis 95.67 10.94 598 154355 66667 32291906
Plasma cell myeloma 93.60 10.94 82 154871 57532 32301041
Mitral valve incompetence 91.23 10.94 212 154741 14659 32343914
Sopor 90.95 10.94 184 154769 11565 32347008
Haematoma 90.55 10.94 299 154654 25385 32333188
Pneumonia 89.01 10.94 1177 153776 354075 32004498
Headache 88.93 10.94 559 154394 195638 32162935
Oedema peripheral 88.27 10.94 881 154072 113210 32245363
Off label use 88.04 10.94 985 153968 305335 32053238
Ejection fraction decreased 87.49 10.94 232 154721 17426 32341147
Cardiogenic shock 87.14 10.94 256 154697 20406 32338167
Fall 86.66 10.94 1364 153589 194837 32163736
Subdural haematoma 85.86 10.94 249 154704 19704 32338869
Venous pressure jugular increased 84.85 10.94 51 154902 753 32357820
Nausea 84.79 10.94 1051 153902 319798 32038775
Anaemia 82.88 10.94 1511 153442 222113 32136460
Dyspnoea exertional 82.29 10.94 386 154567 38575 32319998
Dyspnoea at rest 81.43 10.94 90 154863 3269 32355304
Rash 79.41 10.94 628 154325 208705 32149868
Drug abuse 78.04 10.94 166 154787 80077 32278496
Platelet count decreased 77.30 10.94 283 154670 114308 32244265
Hyponatraemia 75.35 10.94 610 154343 73903 32284670
Atrioventricular block complete 71.54 10.94 142 154811 8802 32349771
Interstitial lung disease 71.15 10.94 542 154411 64459 32294114
Acute coronary syndrome 70.94 10.94 185 154768 13756 32344817
Ventricular hypokinesia 70.28 10.94 101 154852 4799 32353774
Sinusitis 69.74 10.94 44 154909 36516 32322057
Ventricular enlargement 69.38 10.94 37 154916 428 32358145
Inferior vena cava dilatation 68.82 10.94 43 154910 683 32357890
Coronary artery stenosis 67.21 10.94 146 154807 9647 32348926
Drug hypersensitivity 66.35 10.94 158 154795 73242 32285331
Seizure 65.20 10.94 264 154689 103590 32254983
Nasopharyngitis 64.52 10.94 129 154824 63658 32294915
Hypertensive crisis 63.45 10.94 134 154819 8683 32349890
Drug dispensed to wrong patient 62.35 10.94 28 154925 215 32358358
Bradyarrhythmia 61.58 10.94 63 154890 2091 32356482
Treatment failure 60.91 10.94 58 154895 39105 32319468
Fatigue 60.60 10.94 1244 153709 349457 32009116
Depression 60.12 10.94 248 154705 96812 32261761
Vertigo 58.34 10.94 250 154703 24033 32334540
Infusion related reaction 57.43 10.94 80 154873 45519 32313054
Contraindicated product administered 56.77 10.94 210 154743 18866 32339707
Pyrexia 56.74 10.94 1130 153823 318838 32039735
Vascular stent thrombosis 56.22 10.94 65 154888 2482 32356091
Electrocardiogram abnormal 55.19 10.94 118 154835 7712 32350861
Electrolyte imbalance 55.04 10.94 157 154796 12305 32346268
Electrocardiogram QT prolonged 54.82 10.94 350 154603 39291 32319282
Product prescribing error 54.50 10.94 212 154741 19505 32339068
Full blood count decreased 52.30 10.94 9 154944 17001 32341572
Cerebral infarction 52.15 10.94 265 154688 27349 32331224
Circulatory collapse 51.92 10.94 219 154734 20906 32337667
Normocytic anaemia 51.14 10.94 57 154896 2090 32356483
Drug dependence 50.99 10.94 24 154929 23460 32335113
Upper gastrointestinal haemorrhage 50.87 10.94 237 154716 23612 32334961
Acute myocardial infarction 50.69 10.94 442 154511 54707 32303866
Cerebral haematoma 50.63 10.94 86 154867 4725 32353848
Upper respiratory tract infection 50.25 10.94 40 154913 29433 32329140
Vascular purpura 50.05 10.94 50 154903 1612 32356961
Wrong patient received product 49.66 10.94 60 154893 2402 32356171
Diastolic dysfunction 49.29 10.94 89 154864 5135 32353438
No adverse event 49.24 10.94 17 154936 20036 32338537
Injection site pain 49.06 10.94 51 154902 33007 32325566
Renal impairment 48.61 10.94 660 154293 91312 32267261
Infection 48.47 10.94 223 154730 84492 32274081
Back pain 48.39 10.94 320 154633 110733 32247840
Electrocardiogram PR prolongation 47.85 10.94 35 154918 729 32357844
Hyperthyroidism 47.39 10.94 124 154829 9238 32349335
Hypoxia 47.28 10.94 112 154841 52020 32306553
Atrial flutter 46.75 10.94 169 154784 15014 32343559
Drug resistance 46.10 10.94 26 154927 22939 32335634
Pemphigoid 46.08 10.94 115 154838 8321 32350252
Foetal exposure during pregnancy 45.76 10.94 79 154874 41222 32317351
Congestive cardiomyopathy 45.63 10.94 104 154849 7098 32351475
Rheumatoid arthritis 45.10 10.94 90 154863 44454 32314119
Arthralgia 45.03 10.94 471 154482 147977 32210596
Drug withdrawal syndrome 44.98 10.94 20 154933 20211 32338362
Therapeutic product effect decreased 44.75 10.94 49 154904 30968 32327605
Sepsis 43.80 10.94 515 154438 158319 32200254
Blood pressure systolic decreased 43.28 10.94 75 154878 4188 32354385
Product use issue 42.78 10.94 120 154833 52657 32305916
Left ventricular hypertrophy 42.10 10.94 98 154855 6782 32351791
Epistaxis 42.01 10.94 429 154524 55426 32303147
Psoriasis 41.89 10.94 99 154854 46024 32312549
Exercise tolerance decreased 41.81 10.94 77 154876 4511 32354062
Confusional state 41.56 10.94 933 154020 142182 32216391
Neutrophil count decreased 41.38 10.94 103 154850 47036 32311537
Subarachnoid haemorrhage 41.06 10.94 126 154827 10285 32348288
Memory impairment 40.80 10.94 82 154871 40397 32318176
Erysipelas 40.46 10.94 79 154874 4837 32353736
Therapy cessation 40.32 10.94 13 154940 16000 32342573
Rales 40.17 10.94 104 154849 7697 32350876
Graft versus host disease 39.98 10.94 3 154950 10803 32347770
Ventricular arrhythmia 39.85 10.94 80 154873 4999 32353574
Anuria 39.84 10.94 128 154825 10709 32347864
Glomerular filtration rate decreased 39.78 10.94 143 154810 12668 32345905
Hypomagnesaemia 39.46 10.94 186 154767 18619 32339954
Respiratory failure 39.42 10.94 324 154629 106858 32251715
Palpitations 39.37 10.94 300 154653 35669 32322904
Constipation 39.12 10.94 399 154554 125974 32232599
Abnormal behaviour 39.08 10.94 41 154912 26425 32332148
Product monitoring error 38.30 10.94 54 154899 2520 32356053
Mitral valve thickening 37.10 10.94 24 154929 406 32358167
Insomnia 37.06 10.94 303 154650 100045 32258528
Hemiparesis 36.96 10.94 160 154793 15447 32343126
Product quality issue 36.88 10.94 23 154930 19210 32339363
Respiratory tract haemorrhage 36.57 10.94 34 154919 1001 32357572
Chest pain 36.57 10.94 811 154142 123326 32235247
Nephrolithiasis 36.47 10.94 46 154907 27308 32331265
Feeling abnormal 36.40 10.94 156 154797 60267 32298306
Intestinal haemorrhage 36.35 10.94 61 154892 3318 32355255
Stomatitis 36.02 10.94 87 154866 40142 32318431
Hypokalaemia 35.80 10.94 411 154542 54683 32303890
Therapeutic response decreased 35.17 10.94 43 154910 25877 32332696
Duodenal ulcer haemorrhage 35.10 10.94 75 154878 4899 32353674
Hypoglycaemia 35.03 10.94 405 154548 53977 32304596
Stress 34.94 10.94 37 154916 23745 32334828
Pericardial haemorrhage 34.93 10.94 57 154896 3029 32355544
Bone marrow failure 34.74 10.94 57 154896 30347 32328226
Anxiety 34.49 10.94 292 154661 95713 32262860
Systemic infection 34.28 10.94 47 154906 2136 32356437
Intentional product use issue 34.18 10.94 96 154857 42115 32316458
Cardiac murmur 34.12 10.94 93 154860 7098 32351475
Left ventricular enlargement 34.09 10.94 27 154926 636 32357937
Hypocoagulable state 33.49 10.94 32 154921 976 32357597
Atrial tachycardia 32.88 10.94 46 154907 2131 32356442
Orthopnoea 32.83 10.94 74 154879 5013 32353560
Deep vein thrombosis 32.82 10.94 174 154779 63539 32295034
Strangury 32.57 10.94 15 154938 123 32358450
Migraine 32.41 10.94 13 154940 13972 32344601
Degenerative mitral valve disease 32.27 10.94 18 154935 229 32358344
Ocular myasthenia 32.20 10.94 18 154935 230 32358343
Accidental exposure to product 32.17 10.94 7 154946 11195 32347378
Brain natriuretic peptide increased 31.69 10.94 66 154887 4234 32354339
Atrial thrombosis 31.54 10.94 43 154910 1944 32356629
Device issue 31.53 10.94 3 154950 8909 32349664
Influenza 31.41 10.94 113 154840 45901 32312672
Torsade de pointes 31.38 10.94 92 154861 7323 32351250
Cerebral ventricular rupture 31.34 10.94 16 154937 168 32358405
Tongue oedema 30.78 10.94 52 154901 2844 32355729
Hepatic vein dilatation 30.70 10.94 17 154936 213 32358360
Nasal congestion 30.64 10.94 31 154922 20320 32338253
Injection site erythema 30.32 10.94 16 154937 14652 32343921
Atrial enlargement 30.24 10.94 19 154934 305 32358268
Occult blood 30.17 10.94 22 154931 456 32358117
Peritonitis bacterial 29.98 10.94 11 154942 12485 32346088
Intraventricular haemorrhage 29.90 10.94 54 154899 3116 32355457
Cardiac aneurysm 29.52 10.94 29 154924 916 32357657
Ischaemic cardiomyopathy 29.33 10.94 82 154871 6352 32352221
Irritability 29.33 10.94 45 154908 24609 32333964
Osteonecrosis 29.04 10.94 22 154931 16600 32341973
Therapeutic drug monitoring analysis not performed 29.01 10.94 22 154931 485 32358088
Acute pulmonary oedema 28.97 10.94 92 154861 7649 32350924
Faeces discoloured 28.95 10.94 144 154809 14733 32343840
ECG signs of myocardial ischaemia 28.86 10.94 16 154937 201 32358372
Urogenital haemorrhage 28.29 10.94 22 154931 504 32358069
Tricuspid valve incompetence 28.27 10.94 103 154850 9184 32349389
Premature baby 28.12 10.94 28 154925 18490 32340083
Flushing 28.11 10.94 67 154886 31060 32327513
Hypokinesia 27.98 10.94 96 154857 8309 32350264
Respiratory arrest 27.92 10.94 60 154893 28848 32329725
Sinoatrial block 27.81 10.94 21 154932 460 32358113
Blood glucose fluctuation 27.77 10.94 60 154893 3949 32354624
Cardiovascular insufficiency 27.75 10.94 36 154917 1550 32357023
Staphylococcal infection 27.60 10.94 72 154881 32367 32326206
Loss of personal independence in daily activities 27.34 10.94 54 154899 26779 32331794
Dizziness 27.17 10.94 1240 153713 208378 32150195
Spinal cord haemorrhage 27.15 10.94 18 154935 318 32358255
Aspartate aminotransferase increased 27.14 10.94 195 154758 66234 32292339
Right atrial hypertrophy 27.06 10.94 18 154935 320 32358253
Pulmonary vascular disorder 26.83 10.94 23 154930 607 32357966
Arthropathy 26.80 10.94 41 154912 22448 32336125
Duodenitis 26.51 10.94 64 154889 4535 32354038
Injection site reaction 26.41 10.94 11 154942 11558 32347015
Hypersensitivity 26.37 10.94 164 154789 57594 32300979
Subacute cutaneous lupus erythematosus 26.34 10.94 25 154928 756 32357817
Vascular stent stenosis 26.24 10.94 29 154924 1053 32357520
Loss of consciousness 26.15 10.94 546 154407 82161 32276412
Pulmonary fibrosis 26.06 10.94 154 154799 16820 32341753
Systolic dysfunction 25.65 10.94 42 154911 2238 32356335
Pulmonary function test abnormal 25.63 10.94 40 154913 2046 32356527
Haematoma muscle 25.62 10.94 28 154925 1004 32357569
Supine hypertension 25.54 10.94 18 154935 353 32358220
Malignant neoplasm progression 25.45 10.94 245 154708 78251 32280322
Abnormal loss of weight 25.42 10.94 58 154895 3961 32354612
Cardiac failure acute 25.35 10.94 106 154847 10078 32348495
Needle fatigue 25.28 10.94 19 154934 413 32358160
Subdural haemorrhage 25.28 10.94 49 154904 2984 32355589
Toxic skin eruption 25.19 10.94 116 154837 11498 32347075
Discharge 25.18 10.94 13 154940 140 32358433
Febrile infection 25.00 10.94 41 154912 2188 32356385
Anhedonia 24.90 10.94 5 154948 8459 32350114
Cellulitis 24.86 10.94 139 154814 50091 32308482
Tachyarrhythmia 24.85 10.94 52 154901 3347 32355226
Hypersomnia 24.79 10.94 13 154940 11948 32346625
Thrombosis 24.66 10.94 123 154830 45631 32312942
Oesophageal perforation 24.60 10.94 21 154932 551 32358022
Renal failure 24.59 10.94 826 154127 133652 32224921
Muscle haemorrhage 24.56 10.94 56 154897 3823 32354750
Ventricular extrasystoles 24.54 10.94 118 154835 11908 32346665
Small intestinal obstruction 24.53 10.94 19 154934 14177 32344396
Ill-defined disorder 24.53 10.94 13 154940 11876 32346697
Cerebellar haemorrhage 24.49 10.94 33 154920 1475 32357098
Embolic stroke 24.47 10.94 55 154898 3719 32354854
Blood lactic acid 24.40 10.94 18 154935 380 32358193
Aortic stenosis 24.27 10.94 59 154894 4199 32354374
Hypovolaemic shock 24.21 10.94 80 154873 6792 32351781
Bacteraemia 24.19 10.94 29 154924 17604 32340969
Therapeutic product effect incomplete 24.12 10.94 108 154845 41233 32317340
Haematemesis 24.09 10.94 219 154734 27416 32331157
Poisoning deliberate 24.07 10.94 76 154877 6299 32352274
Metabolic acidosis 23.97 10.94 298 154655 40401 32318172
Hypocalcaemia 23.96 10.94 190 154763 22864 32335709
Hypochromasia 23.92 10.94 17 154936 338 32358235
Renal injury 23.69 10.94 14 154939 12041 32346532
Transplant rejection 23.66 10.94 9 154944 9990 32348583
Immune reconstitution inflammatory syndrome 23.65 10.94 8 154945 9551 32349022
Haematochezia 23.48 10.94 288 154665 38920 32319653
Blood creatinine increased 23.42 10.94 612 154341 95520 32263053
Eosinophilia 23.42 10.94 201 154752 24757 32333816
Atrioventricular block second degree 23.38 10.94 51 154902 3379 32355194
Retinal artery occlusion 23.38 10.94 35 154918 1726 32356847
Monoparesis 23.31 10.94 36 154917 1825 32356748
Incorrect dose administered 23.26 10.94 87 154866 34941 32323632
Immune-mediated myositis 23.25 10.94 34 154919 1641 32356932
Fungal infection 23.24 10.94 23 154930 15232 32343341
Abdominal discomfort 23.22 10.94 151 154802 52473 32306100
Jaundice 23.17 10.94 257 154696 33901 32324672
Product use in unapproved indication 23.14 10.94 285 154668 86919 32271654
Haemothorax 23.00 10.94 54 154899 3758 32354815
Intestinal obstruction 22.83 10.94 40 154913 20758 32337815
Psoriatic arthropathy 22.82 10.94 31 154922 17829 32340744
Left ventricular failure 22.67 10.94 65 154888 5108 32353465
Tremor 22.57 10.94 263 154690 81014 32277559
Agranulocytosis 22.52 10.94 190 154763 23287 32335286
Urticaria 22.45 10.94 179 154774 59435 32299138
Postrenal failure 22.33 10.94 18 154935 435 32358138
Hepatitis C 22.23 10.94 19 154934 13499 32345074
Gait spastic 22.21 10.94 19 154934 500 32358073
Left atrial enlargement 22.13 10.94 21 154932 635 32357938
Liver palpable 22.10 10.94 15 154938 276 32358297
Cardio-respiratory arrest 22.08 10.94 166 154787 55823 32302750
Psychotic disorder 22.04 10.94 48 154905 22972 32335601
Aspergillus infection 21.97 10.94 14 154939 11560 32347013
Ventricular hyperkinesia 21.79 10.94 14 154939 234 32358339
Myocardial ischaemia 21.65 10.94 152 154801 17607 32340966
Adverse event 21.65 10.94 28 154925 16444 32342129
Laryngeal discomfort 21.63 10.94 12 154941 151 32358422
Laboratory test abnormal 21.60 10.94 36 154917 19051 32339522
Adverse drug reaction 21.54 10.94 58 154895 25803 32332770
Inappropriate antidiuretic hormone secretion 21.54 10.94 114 154839 11949 32346624
Haemarthrosis 21.53 10.94 49 154904 3341 32355232
Nuchal rigidity 21.45 10.94 18 154935 461 32358112
Pallor 21.33 10.94 184 154769 22697 32335876
Epstein-Barr virus infection 21.26 10.94 4 154949 7086 32351487
Mechanical urticaria 21.20 10.94 10 154943 87 32358486
Emotional distress 21.14 10.94 28 154925 16278 32342295
Gastritis erosive 21.08 10.94 70 154883 5957 32352616
Liver function test abnormal 21.05 10.94 239 154714 31708 32326865
Ear infection 21.02 10.94 7 154946 8441 32350132
Viral infection 20.97 10.94 28 154925 16222 32342351
Heart rate irregular 20.51 10.94 126 154827 13952 32344621
Herpes zoster 20.40 10.94 82 154871 32259 32326314
Decreased appetite 20.37 10.94 597 154356 160216 32198357
Bronchial wall thickening 20.25 10.94 24 154929 941 32357632
Bundle branch block left 20.11 10.94 67 154886 5712 32352861
Basilar artery thrombosis 20.09 10.94 12 154941 175 32358398
Immune thrombocytopenia 20.03 10.94 87 154866 8410 32350163
Blood glucose decreased 19.94 10.94 21 154932 13513 32345060
Procalcitonin increased 19.88 10.94 32 154921 1681 32356892
Treatment noncompliance 19.78 10.94 65 154888 27137 32331436
Bleeding time prolonged 19.76 10.94 20 154933 655 32357918
Tendon rupture 19.75 10.94 78 154875 7225 32351348
Nicotine dependence 19.64 10.94 18 154935 520 32358053
Cardioversion 19.61 10.94 23 154930 892 32357681
Alanine aminotransferase increased 19.52 10.94 260 154693 78219 32280354
Cerebellar haematoma 19.50 10.94 13 154940 232 32358341
Eye injury 19.49 10.94 20 154933 666 32357907
Cardiac septal hypertrophy 19.29 10.94 14 154939 288 32358285
Relapsing-remitting multiple sclerosis 19.26 10.94 19 154934 603 32357970
Steatorrhoea 19.24 10.94 21 154932 752 32357821
Procalcitonin abnormal 19.19 10.94 10 154943 110 32358463
Exposure during pregnancy 19.18 10.94 10 154943 9219 32349354
Asthma 19.15 10.94 127 154826 43938 32314635
Therapeutic response unexpected 19.12 10.94 11 154942 9601 32348972
Mucosal inflammation 19.11 10.94 88 154865 33346 32325227
Cardiac failure congestive 19.02 10.94 287 154666 84565 32274008
Injection site swelling 19.02 10.94 11 154942 9573 32349000
Histamine level increased 18.94 10.94 8 154945 52 32358521
Sinus node dysfunction 18.89 10.94 52 154901 3992 32354581
Infected skin ulcer 18.46 10.94 29 154924 1492 32357081
Ventricular asystole 18.44 10.94 11 154942 160 32358413
Crying 18.39 10.94 3 154950 5893 32352680
Intentional product misuse 18.25 10.94 99 154854 35952 32322621
Vascular pseudoaneurysm 18.20 10.94 35 154918 2119 32356454
Drug level fluctuating 18.19 10.94 17 154936 504 32358069
Abdominal wall haematoma 18.12 10.94 31 154922 1713 32356860
Therapy non-responder 18.05 10.94 87 154866 32567 32326006
Subcutaneous haematoma 18.01 10.94 23 154930 975 32357598
Therapy interrupted 17.93 10.94 8 154945 8070 32350503
Drug intolerance 17.93 10.94 153 154800 50082 32308491
Drug reaction with eosinophilia and systemic symptoms 17.91 10.94 235 154718 32250 32326323
Base excess decreased 17.86 10.94 12 154941 217 32358356
Localised infection 17.79 10.94 28 154925 15159 32343414
Cytomegalovirus viraemia 17.77 10.94 5 154948 6722 32351851
Oliguria 17.68 10.94 82 154871 8152 32350421
Genital herpes simplex 17.67 10.94 10 154943 131 32358442
Melanoderma 17.64 10.94 11 154942 174 32358399
Infusion site induration 17.58 10.94 12 154941 223 32358350
Hypochromic anaemia 17.51 10.94 21 154932 834 32357739
Head injury 17.50 10.94 144 154809 17519 32341054
Benign gastrointestinal neoplasm 17.41 10.94 10 154943 135 32358438
Polymerase chain reaction 17.35 10.94 9 154944 98 32358475
Weight decreased 17.27 10.94 627 154326 164191 32194382
Osteomyelitis 17.22 10.94 30 154923 15603 32342970
Xyphoid retraction 17.16 10.94 11 154942 183 32358390
Tachycardia 17.14 10.94 496 154457 78592 32279981
Abdominal distension 17.09 10.94 159 154794 51136 32307437
Synovitis 17.04 10.94 16 154937 10862 32347711
Anger 16.95 10.94 19 154934 11885 32346688
Granulocytopenia 16.92 10.94 5 154948 6510 32352063
Tooth disorder 16.87 10.94 14 154939 10093 32348480
Visual acuity reduced 16.84 10.94 33 154920 16412 32342161
Back disorder 16.71 10.94 5 154948 6458 32352115
Injection site haemorrhage 16.62 10.94 10 154943 8518 32350055
Gout 16.62 10.94 149 154804 18579 32339994
Chills 16.52 10.94 267 154686 77817 32280756
Blood chloride increased 16.50 10.94 41 154912 2958 32355615
Antimicrobial susceptibility test resistant 16.49 10.94 12 154941 248 32358325
Chronic kidney disease 16.48 10.94 275 154678 39700 32318873
Knee arthroplasty 16.47 10.94 4 154949 5933 32352640
Oropharyngeal swelling 16.45 10.94 16 154937 499 32358074
Oesophageal infection 16.44 10.94 12 154941 249 32358324
Peripheral artery stenosis 16.43 10.94 21 154932 891 32357682
Aggression 16.39 10.94 115 154838 39274 32319299
Atypical fibroxanthoma 16.37 10.94 11 154942 199 32358374
Muscle spasms 16.19 10.94 237 154716 70181 32288392
Concomitant disease progression 16.08 10.94 37 154916 2541 32356032
Traumatic intracranial haemorrhage 16.06 10.94 18 154935 664 32357909
Right atrial enlargement 16.00 10.94 12 154941 260 32358313
Dissociation 15.99 10.94 24 154929 1186 32357387
Tuberculosis 15.97 10.94 11 154942 8718 32349855
Surgery 15.96 10.94 22 154931 12577 32345996
Myelodysplastic syndrome 15.90 10.94 46 154907 19992 32338581
Brain stem infarction 15.89 10.94 25 154928 1288 32357285
Mucosal haemorrhage 15.87 10.94 28 154925 1586 32356987
Right ventricular hypertrophy 15.85 10.94 21 154932 923 32357650
Hyperkaliuria 15.83 10.94 10 154943 162 32358411
Intracranial haematoma 15.76 10.94 14 154939 388 32358185
Swelling 15.70 10.94 112 154841 38110 32320463
Puncture site haematoma 15.62 10.94 10 154943 166 32358407
Blood thyroid stimulating hormone increased 15.62 10.94 42 154911 3180 32355393
Joint range of motion decreased 15.60 10.94 5 154948 6177 32352396
Adenomatous polyposis coli 15.57 10.94 10 154943 167 32358406
Venous pressure jugular decreased 15.56 10.94 7 154946 54 32358519
Neutropenia 15.54 10.94 538 154415 141637 32216936
Cholestasis 15.51 10.94 197 154756 26836 32331737
Hyperlipasaemia 15.40 10.94 16 154937 541 32358032
Vertebrobasilar insufficiency 15.39 10.94 9 154944 126 32358447
Vomiting 15.31 10.94 943 154010 234614 32123959
Perihepatic abscess 15.27 10.94 8 154945 89 32358484
Gravitational oedema 15.26 10.94 17 154936 623 32357950
Injection site pruritus 15.23 10.94 5 154948 6085 32352488
Anorectal discomfort 15.22 10.94 30 154923 1850 32356723
Fear 15.12 10.94 19 154934 11300 32347273
Leptotrichia infection 15.12 10.94 8 154945 91 32358482
Brain natriuretic peptide abnormal 15.07 10.94 13 154940 346 32358227
Oxygen consumption decreased 15.07 10.94 10 154943 177 32358396
Crystalluria 15.03 10.94 15 154938 483 32358090
Vasodilatation 15.01 10.94 22 154931 1064 32357509
Hiccups 14.98 10.94 15 154938 9880 32348693
Femoral artery aneurysm 14.97 10.94 10 154943 179 32358394
Hepatic function abnormal 14.93 10.94 139 154814 44701 32313872
C-reactive protein decreased 14.87 10.94 28 154925 1668 32356905
Poikiloderma 14.83 10.94 10 154943 182 32358391
Neurotoxicity 14.78 10.94 31 154922 15039 32343534
Hyperammonaemia 14.76 10.94 5 154948 5964 32352609
Rash maculo-papular 14.74 10.94 201 154752 27821 32330752
Post procedural haematoma 14.72 10.94 27 154926 1577 32356996
Procedural haemorrhage 14.70 10.94 35 154918 2458 32356115
Retinal phototoxicity 14.65 10.94 4 154949 4 32358569
Poisoning 14.63 10.94 19 154934 11139 32347434
Multiple drug therapy 14.61 10.94 13 154940 361 32358212
Primary hypoparathyroidism 14.60 10.94 6 154947 36 32358537
Prolonged expiration 14.60 10.94 10 154943 187 32358386
Facial asymmetry 14.58 10.94 12 154941 299 32358274
Hepatitis B 14.52 10.94 6 154947 6335 32352238
Impaired work ability 14.44 10.94 5 154948 5883 32352690
Helicobacter test positive 14.43 10.94 18 154935 745 32357828
Gastroduodenal ulcer 14.38 10.94 13 154940 369 32358204
Cardiac tamponade 14.37 10.94 55 154898 5020 32353553
Haemorrhagic stroke 14.27 10.94 65 154888 6413 32352160
Hallucination, auditory 14.22 10.94 17 154936 10333 32348240
Gastrointestinal haemorrhage 14.21 10.94 527 154426 86355 32272218
Nephroangiosclerosis 14.19 10.94 10 154943 196 32358377
Cardioactive drug level increased 14.19 10.94 28 154925 1728 32356845
Tricuspid valve calcification 14.18 10.94 4 154949 5 32358568
Troponin T increased 14.13 10.94 26 154927 1522 32357051
Necrotising myositis 14.11 10.94 15 154938 521 32358052
Hypoglycaemic coma 14.08 10.94 34 154919 2409 32356164
Phlebitis infective 14.08 10.94 9 154944 149 32358424
Stenosis 13.97 10.94 21 154932 1039 32357534
Purpura 13.97 10.94 92 154861 10433 32348140
Blood creatine phosphokinase increased 13.97 10.94 299 154654 45177 32313396
Nightmare 13.95 10.94 109 154844 13057 32345516
Haemorrhage intracranial 13.90 10.94 126 154827 15761 32342812
Peripheral arterial occlusive disease 13.88 10.94 59 154894 5650 32352923
Endocarditis 13.82 10.94 65 154888 6499 32352074
Oropharyngeal pain 13.81 10.94 90 154863 31262 32327311
Rash vesicular 13.79 10.94 36 154917 2678 32355895
Road traffic accident 13.72 10.94 40 154913 17341 32341232
Delusion 13.68 10.94 26 154927 13082 32345491
Bronchitis 13.68 10.94 129 154824 41378 32317195
Adrenomegaly 13.67 10.94 13 154940 394 32358179
Blood potassium decreased 13.62 10.94 40 154913 17298 32341275
Myositis 13.60 10.94 96 154857 11139 32347434
Paranoia 13.54 10.94 19 154934 10780 32347793
Echocardiogram abnormal 13.52 10.94 19 154934 884 32357689
Bone disorder 13.51 10.94 8 154945 6872 32351701
Macular ischaemia 13.43 10.94 7 154946 77 32358496
Haematocrit decreased 13.39 10.94 92 154861 31570 32327003
Hemiataxia 13.37 10.94 6 154947 46 32358527
Pneumonitis chemical 13.34 10.94 9 154944 164 32358409
Gastrointestinal angiodysplasia 13.31 10.94 16 154937 637 32357936
Dyspnoea paroxysmal nocturnal 13.25 10.94 25 154928 1492 32357081
Polyneuropathy 13.23 10.94 108 154845 13107 32345466
Inappropriate schedule of product administration 13.22 10.94 147 154806 45678 32312895
Prescription drug used without a prescription 13.17 10.94 23 154930 1292 32357281
Aortic valve stenosis 13.17 10.94 31 154922 2161 32356412
Cardiovascular somatic symptom disorder 13.15 10.94 6 154947 48 32358525
Cystitis haemorrhagic 13.15 10.94 4 154949 5110 32353463
Angiogram 13.13 10.94 10 154943 222 32358351
Faeces pale 13.11 10.94 25 154928 1504 32357069
Vitamin D deficiency 13.10 10.94 60 154893 5934 32352639
Tuberculosis bladder 13.05 10.94 3 154950 0 32358573
Traumatic ulcer 13.05 10.94 3 154950 0 32358573
Neonatal deafness 13.05 10.94 3 154950 0 32358573
Prostatic specific antigen increased 13.04 10.94 27 154926 13160 32345413
C-reactive protein abnormal 13.04 10.94 7 154946 6349 32352224
Hyperkinetic heart syndrome 12.97 10.94 8 154945 124 32358449
Musculoskeletal stiffness 12.95 10.94 122 154831 39142 32319431
Drop attacks 12.93 10.94 15 154938 575 32357998
Jugular vein distension 12.93 10.94 15 154938 575 32357998
Suspected product quality issue 12.92 10.94 9 154944 173 32358400
Acne 12.86 10.94 18 154935 10224 32348349
Extradural haematoma 12.86 10.94 22 154931 1216 32357357
Injection site bruising 12.85 10.94 11 154942 7809 32350764
Medication error 12.83 10.94 164 154789 22371 32336202
Scar 12.83 10.94 6 154947 5887 32352686
Brain contusion 12.82 10.94 18 154935 837 32357736
Unresponsive to stimuli 12.80 10.94 78 154875 27531 32331042
Necrotising retinitis 12.73 10.94 18 154935 842 32357731
Bronchopulmonary aspergillosis 12.73 10.94 29 154924 13658 32344915
Gastrointestinal ulcer 12.71 10.94 27 154926 1756 32356817
Subclavian artery occlusion 12.70 10.94 8 154945 129 32358444
Periorbital haematoma 12.69 10.94 12 154941 361 32358212
Stress cardiomyopathy 12.68 10.94 27 154926 1759 32356814
Glycosylated haemoglobin decreased 12.64 10.94 12 154941 363 32358210
Peritonitis 12.63 10.94 59 154894 22271 32336302
Burning feet syndrome 12.62 10.94 7 154946 88 32358485
Atrioventricular block first degree 12.61 10.94 58 154895 5745 32352828
Eczema infected 12.60 10.94 5 154948 27 32358546
Blood potassium increased 12.59 10.94 129 154824 16675 32341898
Pseudohyponatraemia 12.55 10.94 7 154946 89 32358484
Basal ganglia haemorrhage 12.51 10.94 18 154935 856 32357717
Muscle enzyme increased 12.50 10.94 10 154943 239 32358334
Hirsutism 12.49 10.94 9 154944 183 32358390
Product complaint 12.49 10.94 6 154947 5797 32352776
Bronchial secretion retention 12.49 10.94 20 154933 1046 32357527
Acute myeloid leukaemia 12.48 10.94 48 154905 19126 32339447
Blood count abnormal 12.34 10.94 27 154926 12899 32345674
Atelectasis 12.33 10.94 40 154913 16768 32341805
Upper airway obstruction 12.31 10.94 15 154938 606 32357967
Cytomegalovirus infection 12.31 10.94 71 154882 25393 32333180
Carotid artery stenosis 12.27 10.94 51 154902 4835 32353738
Reticulocytosis 12.26 10.94 11 154942 309 32358264
Seasonal allergy 12.25 10.94 5 154948 5319 32353254
Left ventricular dilatation 12.22 10.94 16 154937 695 32357878
Hepatotoxicity 12.21 10.94 49 154904 19288 32339285
Laryngeal haematoma 12.18 10.94 8 154945 139 32358434
Documented hypersensitivity to administered product 12.17 10.94 11 154942 312 32358261
Glycosylated haemoglobin increased 12.13 10.94 88 154865 10301 32348272
Cardiac ventricular thrombosis 12.11 10.94 18 154935 882 32357691
Pyelitis 12.09 10.94 7 154946 96 32358477
Intrapericardial thrombosis 12.09 10.94 6 154947 59 32358514
Skin pressure mark 12.09 10.94 6 154947 59 32358514
Blood loss anaemia 12.07 10.94 72 154881 7890 32350683
Mania 12.02 10.94 17 154936 9615 32348958
Complication associated with device 12.01 10.94 7 154946 6065 32352508
Wrong technique in product usage process 11.97 10.94 108 154845 34951 32323622
Mean platelet volume increased 11.94 10.94 13 154940 464 32358109
Cerebrospinal fluid circulation disorder 11.92 10.94 4 154949 12 32358561
Rapid correction of hyponatraemia 11.91 10.94 7 154946 99 32358474
Pseudolymphoma 11.87 10.94 14 154939 546 32358027
Posterior reversible encephalopathy syndrome 11.85 10.94 17 154936 9559 32349014
Conduction disorder 11.80 10.94 28 154925 1962 32356611
Genitourinary symptom 11.77 10.94 5 154948 33 32358540
Blood triglycerides decreased 11.75 10.94 6 154947 63 32358510
Electrocardiogram T wave inversion 11.73 10.94 30 154923 2204 32356369
Renal artery occlusion 11.73 10.94 7 154946 102 32358471
Angiocardiogram 11.69 10.94 9 154944 203 32358370
Acute graft versus host disease 11.69 10.94 8 154945 6362 32352211
Disability 11.67 10.94 4 154949 4736 32353837
Chest wall haematoma 11.66 10.94 8 154945 150 32358423
Respiratory tract infection 11.64 10.94 130 154823 17175 32341398
Hypochloraemia 11.60 10.94 15 154938 644 32357929
Therapeutic response shortened 11.59 10.94 4 154949 4716 32353857
Leukocytosis 11.57 10.94 65 154888 23402 32335171
Head titubation 11.57 10.94 10 154943 267 32358306
Social anxiety disorder 11.57 10.94 10 154943 267 32358306
Bronchostenosis 11.54 10.94 10 154943 268 32358305
Disseminated intravascular coagulation 11.53 10.94 64 154889 23112 32335461
Respiratory depression 11.48 10.94 29 154924 13182 32345391
Skull fracture 11.46 10.94 18 154935 926 32357647
Haemodialysis 11.45 10.94 22 154931 11024 32347549
Cardiac dysfunction 11.45 10.94 27 154926 1884 32356689
Extrasystoles 11.43 10.94 43 154910 3894 32354679
Ejection fraction abnormal 11.41 10.94 18 154935 929 32357644
Sexual dysfunction 11.41 10.94 8 154945 6281 32352292
Haemorrhage subcutaneous 11.41 10.94 31 154922 2362 32356211
Sinus disorder 11.34 10.94 9 154944 6635 32351938
Gastric mucosal lesion 11.34 10.94 14 154939 573 32358000
Product dispensing error 11.29 10.94 61 154892 6444 32352129
Dialysis 11.26 10.94 23 154930 11265 32347308
Hypoaesthesia 11.22 10.94 203 154750 58150 32300423
Oscillopsia 11.18 10.94 5 154948 38 32358535
Thyroiditis acute 11.16 10.94 7 154946 112 32358461
Emotional disorder 11.15 10.94 6 154947 5435 32353138
Subcapsular renal haematoma 11.12 10.94 12 154941 424 32358149
Procedural pain 11.11 10.94 6 154947 5423 32353150
Cardiomyopathy 11.09 10.94 121 154832 15892 32342681
Puncture site infection 11.07 10.94 5 154948 39 32358534
Vasculitic rash 11.06 10.94 18 154935 954 32357619
Hypogammaglobulinaemia 11.01 10.94 8 154945 6168 32352405
Drug ineffective for unapproved indication 10.99 10.94 32 154921 13880 32344693
Pseudofolliculitis 10.99 10.94 3 154950 3 32358570
Nail dystrophy 10.96 10.94 8 154945 166 32358407

Pharmacologic Action:

SourceCodeDescription
ATC C07AB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07FB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FX04 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C09BX02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
CHEBI has role CHEBI:35530 beta-adrenoceptor antagonists
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:66991 sympatholytics
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013565 Sympatholytics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Chronic heart failure off-label use 48447003
Angina pectoris off-label use 194828000
Diastolic heart failure off-label use 418304008 DOID:9775
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Anuria contraindication 2472002 DOID:2983
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Hypomagnesemia contraindication 190855004
Partial atrioventricular block contraindication 195039008
Decompensated cardiac failure contraindication 195111005
Asthma contraindication 195967001 DOID:2841
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Severe chronic obstructive pulmonary disease contraindication 313299006
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Azotemia contraindication 445009001
Acute exacerbation of asthma contraindication 708038006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.65 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.94 WOMBAT-PK
Beta-3 adrenergic receptor GPCR Ki 5.04 WOMBAT-PK
Beta-1 adrenergic receptor GPCR Ki 8.28 CHEMBL

External reference:

IDSource
4023923 VUID
N0000021928 NUI
D00634 KEGG_DRUG
104344-23-2 SECONDARY_CAS_RN
C0053799 UMLSCUI
CHEBI:3127 CHEBI
CHEMBL645 ChEMBL_ID
CHEMBL1472989 ChEMBL_ID
CHEMBL1200708 ChEMBL_ID
DB00612 DRUGBANK_ID
D017298 MESH_DESCRIPTOR_UI
2405 PUBCHEM_CID
7129 IUPHAR_LIGAND_ID
5225 INN_ID
Y41JS2NL6U UNII
142146 RXNORM
38369 MMSL
4291 MMSL
d00709 MMSL
003703 NDDF
003704 NDDF
108547003 SNOMEDCT_US
386868003 SNOMEDCT_US
386869006 SNOMEDCT_US
4020862 VANDF
4023923 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3241 TABLET, FILM COATED 2.50 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3242 TABLET, FILM COATED 5 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3243 TABLET, FILM COATED 10 mg ORAL NDA authorized generic 23 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0501 TABLET, FILM COATED 2.50 mg ORAL ANDA 26 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0503 TABLET, FILM COATED 5 mg ORAL ANDA 26 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0505 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-173 TABLET 2.50 mg ORAL ANDA 20 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-174 TABLET 10 mg ORAL ANDA 20 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-563 TABLET 5 mg ORAL ANDA 20 sections
BISOPROLOL FUMARATE Human Prescription Drug Label 1 15955-373 TABLET, FILM COATED 5 mg ORAL ANDA 11 sections
BISOPROLOL FUMARATE Human Prescription Drug Label 1 15955-374 TABLET, FILM COATED 10 mg ORAL ANDA 11 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 21695-667 TABLET 5 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 21695-670 TABLET 10 mg ORAL ANDA 18 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 21695-808 TABLET, COATED 5 mg ORAL ANDA 23 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 21695-809 TABLET, COATED 10 mg ORAL ANDA 23 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 29300-126 TABLET 5 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 29300-127 TABLET 10 mg ORAL ANDA 18 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 29300-187 TABLET 2.50 mg ORAL ANDA 19 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 29300-188 TABLET 5 mg ORAL ANDA 19 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 29300-189 TABLET 10 mg ORAL ANDA 19 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 33261-918 TABLET 5 mg ORAL ANDA 19 sections
Bisoprolol Fumarate and Hydrochlorothiazide Human Prescription Drug Label 2 42799-920 TABLET, FILM COATED 2.50 mg ORAL ANDA 20 sections
Bisoprolol Fumarate and Hydrochlorothiazide Human Prescription Drug Label 2 42799-921 TABLET, FILM COATED 5 mg ORAL ANDA 20 sections
Bisoprolol Fumarate and Hydrochlorothiazide Human Prescription Drug Label 2 42799-922 TABLET, FILM COATED 10 mg ORAL ANDA 20 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 50090-0789 TABLET 5 mg ORAL ANDA 20 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 50090-0796 TABLET 2.50 mg ORAL ANDA 20 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 50090-0799 TABLET 10 mg ORAL ANDA 20 sections
Bisoprolol Fumarate and Hydrochlorothiazide Human Prescription Drug Label 2 50090-5849 TABLET, FILM COATED 5 mg ORAL ANDA 20 sections
Bisoprolol Fumarate and Hydrochlorothiazide Human Prescription Drug Label 2 50090-5905 TABLET, FILM COATED 10 mg ORAL ANDA 20 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 50268-127 TABLET, FILM COATED 5 mg ORAL ANDA 18 sections