clopidogrel Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
platelet aggregation inhibitors 708 113665-84-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clopidogrel
  • zyllt
  • clopidogrel bisulfate
  • clopidogrel besilate
  • clopidogrel hydrochloride
  • clopidogrel hydrogen sulphate
  • clopidogrel hydrobromide
  • clopidogrel sulfate
  • clopidogrel HCl
A ticlopidine analog and platelet purinergic P2Y receptor antagonist that inhibits adenosine diphosphate-mediated PLATELET AGGREGATION. It is used to prevent THROMBOEMBOLISM in patients with ARTERIAL OCCLUSIVE DISEASES; MYOCARDIAL INFARCTION; STROKE; or ATRIAL FIBRILLATION.
  • Molecular weight: 321.82
  • Formula: C16H16ClNO2S
  • CLOGP: 4.21
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 29.54
  • ALOGS: -4.43
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.05 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.32 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.01 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 23.65 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.06 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 15, 1998 EMA
Nov. 17, 1997 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaemia 1051.29 43.23 376 4057 34416 2319236
Gastrointestinal haemorrhage 905.66 43.23 263 4170 12172 2341480
Haematoma 615.75 43.23 161 4272 4960 2348692
Haematemesis 557.03 43.23 142 4291 3940 2349712
Melaena 536.56 43.23 138 4295 3968 2349684
Rectal haemorrhage 488.01 43.23 138 4295 5718 2347934
Drug interaction 470.24 43.23 201 4232 28962 2324690
Haematochezia 442.07 43.23 125 4308 5170 2348482
Cerebral haemorrhage 366.37 43.23 109 4324 5395 2348257
Vascular stent thrombosis 359.04 43.23 59 4374 133 2353519
Acute myocardial infarction 349.03 43.23 103 4330 4952 2348700
Haemoglobin decreased 345.25 43.23 141 4292 18010 2335642
Labelled drug-drug interaction medication error 341.77 43.23 77 4356 1231 2352421
Epistaxis 308.59 43.23 110 4323 9669 2343983
Dyspnoea 294.63 43.23 206 4227 78527 2275125
Hypotension 284.21 43.23 147 4286 32289 2321363
Fall 282.15 43.23 166 4267 46933 2306719
Haemorrhage intracranial 279.88 43.23 75 4358 2519 2351133
General physical health deterioration 255.51 43.23 106 4327 14033 2339619
Subdural haematoma 252.04 43.23 67 4366 2179 2351473
Upper gastrointestinal haemorrhage 242.88 43.23 64 4369 2010 2351642
Acute kidney injury 230.54 43.23 122 4311 28000 2325652
Extradural haematoma 221.84 43.23 42 4391 263 2353389
Haemorrhage 220.63 43.23 89 4344 10950 2342702
Hemiparesis 210.67 43.23 64 4369 3386 2350266
Angina pectoris 209.86 43.23 66 4367 3921 2349731
Thrombosis in device 206.63 43.23 45 4388 608 2353044
Arterial haemorrhage 206.50 43.23 37 4396 162 2353490
Thrombotic thrombocytopenic purpura 202.99 43.23 46 4387 753 2352899
Vascular pseudoaneurysm 193.23 43.23 37 4396 248 2353404
Vomiting 183.98 43.23 150 4283 71452 2282200
Cardiogenic shock 177.16 43.23 52 4381 2439 2351213
Subarachnoid haemorrhage 176.83 43.23 50 4383 2050 2351602
Medication error 174.55 43.23 64 4369 6067 2347585
Spinal epidural haematoma 173.01 43.23 29 4404 77 2353575
Syncope 172.30 43.23 85 4348 16790 2336862
Diverticulum intestinal 171.81 43.23 39 4394 643 2353009
Contusion 165.85 43.23 76 4357 12734 2340918
Haematuria 164.57 43.23 56 4377 4262 2349390
Myocardial infarction 157.00 43.23 83 4350 18930 2334722
Thrombocytopenia 153.69 43.23 82 4351 19049 2334603
Retroperitoneal haemorrhage 150.25 43.23 34 4399 552 2353100
Asthenia 145.48 43.23 110 4323 46816 2306836
Lymphatic fistula 142.41 43.23 20 4413 3 2353649
Circulatory collapse 140.78 43.23 48 4385 3672 2349980
Femoral hernia incarcerated 137.78 43.23 20 4413 9 2353643
Chest pain 136.68 43.23 87 4346 28050 2325602
Shock haemorrhagic 133.12 43.23 36 4397 1247 2352405
Dyspepsia 129.22 43.23 59 4374 9785 2343867
Hiatus hernia 128.60 43.23 39 4394 2045 2351607
Gastritis erosive 128.29 43.23 32 4401 801 2352851
Pancreatic steatosis 124.99 43.23 20 4413 35 2353617
Abdominal wall haematoma 123.75 43.23 28 4405 454 2353198
Cough 121.45 43.23 86 4347 33031 2320621
Tachyarrhythmia 120.83 43.23 29 4404 615 2353037
Anuria 120.59 43.23 36 4397 1788 2351864
Pruritus 119.85 43.23 95 4338 43245 2310407
Cardiac arrest 119.84 43.23 64 4369 14866 2338786
Duodenal ulcer 118.52 43.23 32 4401 1101 2352551
Vascular stent stenosis 116.97 43.23 21 4412 93 2353559
Wound infection pseudomonas 116.05 43.23 20 4413 66 2353586
Coronary artery disease 115.45 43.23 47 4386 5892 2347760
Contraindicated product administered 114.36 43.23 39 4394 2982 2350670
Product substitution issue 112.01 43.23 44 4389 5025 2348627
Transient ischaemic attack 111.75 43.23 46 4387 5932 2347720
Drug ineffective 110.00 43.23 133 4300 101491 2252161
Hyponatraemia 109.41 43.23 58 4375 13267 2340385
Atrial fibrillation 107.62 43.23 58 4375 13710 2339942
Haemarthrosis 99.97 43.23 23 4410 403 2353249
Aortic valve stenosis 99.45 43.23 22 4411 320 2353332
Hyperkalaemia 98.90 43.23 42 4391 5851 2347801
Confusional state 98.02 43.23 67 4366 24277 2329375
Haemoptysis 97.29 43.23 36 4397 3491 2350161
Dysarthria 96.19 43.23 42 4391 6260 2347392
Drug-induced liver injury 95.62 43.23 36 4397 3663 2349989
Acute coronary syndrome 95.10 43.23 29 4404 1548 2352104
Completed suicide 94.54 43.23 62 4371 20972 2332680
Coma scale abnormal 94.53 43.23 25 4408 793 2352859
Product administration error 93.38 43.23 36 4397 3907 2349745
Inflammatory marker increased 93.15 43.23 23 4410 551 2353101
Seroma 92.93 43.23 20 4413 254 2353398
Petechiae 91.32 43.23 30 4403 2042 2351610
Oedema peripheral 90.01 43.23 63 4370 23700 2329952
Nausea 88.90 43.23 126 4307 112063 2241589
Drug resistance 88.19 43.23 31 4402 2593 2351059
Cardiovascular disorder 87.55 43.23 30 4403 2325 2351327
Spinal cord compression 87.15 43.23 22 4411 578 2353074
Neutropenia 85.99 43.23 59 4374 21489 2332163
Abdominal pain 85.71 43.23 71 4362 34303 2319349
Oesophageal intramural haematoma 85.26 43.23 12 4421 2 2353650
Myelodysplastic syndrome 85.10 43.23 30 4403 2530 2351122
Product prescribing error 84.54 43.23 31 4402 2929 2350723
Bradycardia 83.46 43.23 44 4389 9937 2343715
Pulmonary alveolar haemorrhage 82.90 43.23 22 4411 707 2352945
Post procedural haemorrhage 82.53 43.23 25 4408 1304 2352348
Groin pain 82.14 43.23 25 4408 1325 2352327
Kidney rupture 81.88 43.23 13 4420 21 2353631
Lower gastrointestinal haemorrhage 79.95 43.23 23 4410 1001 2352651
Haemorrhagic diathesis 79.35 43.23 20 4413 522 2353130
Wound dehiscence 78.92 43.23 21 4412 682 2352970
Aplastic anaemia 78.21 43.23 22 4411 882 2352770
Faecaloma 77.95 43.23 22 4411 893 2352759
Condition aggravated 77.52 43.23 65 4368 31914 2321738
Blood loss anaemia 77.41 43.23 23 4410 1122 2352530
Peripheral swelling 76.93 43.23 51 4382 17546 2336106
Aortic arteriosclerosis 76.37 43.23 20 4413 610 2353042
Muscle haemorrhage 76.08 43.23 20 4413 619 2353033
Faeces discoloured 75.96 43.23 27 4406 2332 2351320
Left ventricular dysfunction 75.60 43.23 23 4410 1217 2352435
Hepatic cyst 75.35 43.23 20 4413 643 2353009
Iron deficiency anaemia 75.15 43.23 26 4407 2073 2351579
Gastritis 74.70 43.23 32 4401 4549 2349103
Overdose 73.54 43.23 52 4381 19855 2333797
Obstructive airways disorder 73.29 43.23 23 4410 1350 2352302
Thrombosis 72.75 43.23 39 4394 9105 2344547
Cerebral infarction 72.37 43.23 31 4402 4406 2349246
Head injury 71.84 43.23 30 4403 4004 2349648
Procedural haemorrhage 71.04 43.23 18 4415 480 2353172
Paraesthesia 70.92 43.23 53 4380 22035 2331617
Coagulopathy 70.44 43.23 27 4406 2882 2350770
Mitral valve incompetence 70.21 43.23 26 4407 2524 2351128
Ecchymosis 70.07 43.23 23 4410 1560 2352092
Fatigue 69.56 43.23 97 4336 84776 2268876
Treatment noncompliance 68.90 43.23 32 4401 5502 2348150
Eructation 68.48 43.23 21 4412 1141 2352511
Endothelial dysfunction 68.43 43.23 12 4421 45 2353607
Postoperative wound infection 67.89 43.23 21 4412 1175 2352477
Intestinal haemorrhage 67.25 43.23 18 4415 598 2353054
Cardiac tamponade 66.87 43.23 19 4414 790 2352862
Pericardial haemorrhage 66.70 43.23 16 4417 338 2353314
Abdominal pain upper 66.47 43.23 51 4382 22049 2331603
Ischaemic stroke 66.38 43.23 27 4406 3370 2350282
Rhabdomyolysis 66.00 43.23 33 4400 6671 2346981
Escherichia infection 65.41 43.23 21 4412 1327 2352325
Cardiac failure 65.14 43.23 40 4393 12054 2341598
Tricuspid valve incompetence 65.09 43.23 22 4411 1634 2352018
Decreased appetite 64.43 43.23 56 4377 28835 2324817
Joint dislocation 63.82 43.23 21 4412 1435 2352217
Dizziness 63.54 43.23 77 4356 58588 2295064
Eye haemorrhage 61.12 43.23 20 4413 1343 2352309
Urinary retention 61.05 43.23 26 4407 3641 2350011
Oesophagitis 60.96 43.23 22 4411 1984 2351668
Pallor 60.54 43.23 26 4407 3716 2349936
Hepatitis cholestatic 60.17 43.23 19 4414 1138 2352514
Cerebrovascular accident 59.41 43.23 46 4387 20140 2333512
Long QT syndrome 59.05 43.23 16 4417 557 2353095
Pulmonary hypertension 58.80 43.23 28 4405 5090 2348562
Mucosal haemorrhage 58.63 43.23 13 4420 191 2353461
Leukopenia 58.18 43.23 35 4398 10161 2343491
Osteopenia 57.97 43.23 21 4412 1914 2351738
Platelet count decreased 57.67 43.23 41 4392 15772 2337880
Traumatic haematoma 57.60 43.23 13 4420 208 2353444
Haemorrhagic stroke 57.56 43.23 18 4415 1044 2352608
Abdominal discomfort 56.26 43.23 42 4391 17414 2336238
Hydrocephalus 56.12 43.23 17 4416 886 2352766
Brain midline shift 55.77 43.23 12 4421 152 2353500
Lichen nitidus 54.19 43.23 8 4425 5 2353647
Compartment syndrome 54.12 43.23 14 4419 406 2353246
Haemorrhoidal haemorrhage 54.12 43.23 15 4418 569 2353083
Cerebellar haemorrhage 53.82 43.23 13 4420 283 2353369
Loss of consciousness 53.56 43.23 42 4391 18725 2334927
Platelet disorder 53.52 43.23 13 4420 290 2353362
Vaginal haemorrhage 53.43 43.23 26 4407 4954 2348698
Coronary artery stenosis 53.36 43.23 16 4417 805 2352847
Anal haemorrhage 53.26 43.23 13 4420 296 2353356
Retroperitoneal haematoma 52.68 43.23 14 4419 452 2353200
Anal incontinence 52.23 43.23 19 4414 1753 2351899
Rash 51.59 43.23 70 4363 59488 2294164
Rectosigmoid cancer 51.06 43.23 9 4424 35 2353617
Aphasia 50.69 43.23 25 4408 4903 2348749
Increased tendency to bruise 50.12 43.23 18 4415 1600 2352052
Toxicity to various agents 49.13 43.23 51 4382 32703 2320949
Capillary fragility test 49.05 43.23 7 4426 2 2353650
Acute left ventricular failure 48.28 43.23 10 4423 104 2353548
Diabetic macroangiopathy 47.65 43.23 7 4426 4 2353648
Resuscitation 47.21 43.23 12 4421 324 2353328
Gingival bleeding 45.93 43.23 18 4415 2037 2351615
Abdominal tenderness 45.48 43.23 15 4418 1032 2352620
Jaundice 45.21 43.23 24 4409 5484 2348168
Brain herniation 44.99 43.23 13 4420 574 2353078
Anal stenosis 44.53 43.23 9 4424 82 2353570
International normalised ratio increased 43.97 43.23 26 4407 7310 2346342
Diarrhoea 43.96 43.23 78 4355 83486 2270166
Blood creatine phosphokinase increased 43.92 43.23 23 4410 5113 2348539
Aspiration 43.54 43.23 16 4417 1518 2352134

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal haemorrhage 1683.19 45.37 547 6565 13720 1725949
Anaemia 1266.01 45.37 538 6574 28919 1710750
Melaena 1123.74 45.37 319 6793 4891 1734778
Gastric haemorrhage 856.91 45.37 229 6883 2749 1736920
Haemorrhage 789.89 45.37 284 6828 9545 1730124
Cerebral haemorrhage 724.57 45.37 238 6874 6039 1733630
Haemoglobin decreased 712.28 45.37 307 6805 16807 1722862
Haematochezia 708.87 45.37 221 6891 4711 1734958
Drug interaction 666.27 45.37 341 6771 27617 1712052
Vascular stent thrombosis 613.70 45.37 125 6987 374 1739295
Upper gastrointestinal haemorrhage 588.56 45.37 171 6941 2828 1736841
Haematuria 560.06 45.37 206 6906 7354 1732315
Rectal haemorrhage 535.51 45.37 184 6928 5358 1734311
Haematemesis 528.90 45.37 172 6940 4205 1735464
Labelled drug-drug interaction medication error 509.52 45.37 129 6983 1222 1738447
Acute myocardial infarction 463.92 45.37 186 6926 8401 1731268
Thrombosis in device 445.02 45.37 108 7004 843 1738826
Subdural haematoma 430.24 45.37 139 6973 3318 1736351
Haematoma 412.22 45.37 139 6973 3806 1735863
Chest pain 390.86 45.37 214 6898 19700 1719969
Dyspnoea 382.92 45.37 302 6810 51757 1687912
Epistaxis 373.95 45.37 158 6954 8148 1731521
Haemoptysis 346.33 45.37 129 6983 4747 1734922
Dizziness 345.71 45.37 241 6871 34120 1705549
International normalised ratio increased 331.18 45.37 145 6967 8154 1731515
Contraindicated product administered 326.24 45.37 92 7020 1352 1738317
Haemorrhage intracranial 319.69 45.37 110 7002 3200 1736469
Angina pectoris 317.44 45.37 122 6990 4896 1734773
Fall 294.88 45.37 200 6912 27014 1712655
Hypotension 263.31 45.37 193 6919 29461 1710208
Faeces discoloured 256.01 45.37 86 7026 2318 1737351
Drug ineffective 224.93 45.37 246 6866 63555 1676114
Retroperitoneal haematoma 215.08 45.37 52 7060 397 1739272
Gastric ulcer 212.51 45.37 77 7035 2608 1737061
Subarachnoid haemorrhage 210.99 45.37 69 7043 1705 1737964
Product administration error 201.73 45.37 76 7036 2877 1736792
Asthenia 199.32 45.37 175 6937 34495 1705174
Vascular pseudoaneurysm 198.57 45.37 47 7065 324 1739345
Aphasia 190.01 45.37 76 7036 3385 1736284
Hemiparesis 174.60 45.37 67 7045 2667 1737002
Completed suicide 169.36 45.37 117 6995 16195 1723474
Thrombocytopenia 165.32 45.37 128 6984 21121 1718548
Cerebral infarction 163.20 45.37 77 7035 5132 1734537
Pulmonary alveolar haemorrhage 161.82 45.37 51 7061 1114 1738555
Syncope 159.82 45.37 107 7005 14062 1725607
Muscle haemorrhage 151.93 45.37 45 7067 791 1738878
Transient ischaemic attack 150.62 45.37 71 7041 4720 1734949
Iron deficiency anaemia 148.90 45.37 48 7064 1130 1738539
Drug resistance 146.89 45.37 62 7050 3168 1736501
Lower gastrointestinal haemorrhage 145.65 45.37 47 7065 1110 1738559
Duodenal ulcer 144.94 45.37 52 7060 1708 1737961
Insulin autoimmune syndrome 143.95 45.37 26 7086 29 1739640
Blood loss anaemia 142.21 45.37 44 7068 902 1738767
Intraventricular haemorrhage 140.24 45.37 39 7073 541 1739128
Fatigue 132.11 45.37 168 6944 50613 1689056
Cardiac tamponade 131.56 45.37 42 7070 957 1738712
Haematocrit decreased 130.25 45.37 62 7050 4211 1735458
Gastritis 129.08 45.37 56 7056 3061 1736608
Thrombosis 128.42 45.37 74 7038 7447 1732222
Post procedural haemorrhage 128.18 45.37 45 7067 1385 1738284
Subdural haemorrhage 128.14 45.37 37 7075 592 1739077
Cardiac arrest 126.04 45.37 97 7015 15833 1723836
Shock haemorrhagic 124.79 45.37 44 7068 1372 1738297
Ecchymosis 121.61 45.37 40 7072 1005 1738664
Headache 121.25 45.37 133 6979 34243 1705426
Spinal cord haemorrhage 119.69 45.37 24 7088 64 1739605
Thrombotic thrombocytopenic purpura 119.05 45.37 36 7076 681 1738988
Myocardial infarction 118.86 45.37 118 6994 27056 1712613
Coronary artery restenosis 112.79 45.37 28 7084 241 1739428
Duodenal ulcer haemorrhage 112.00 45.37 35 7077 742 1738927
Renal impairment 108.50 45.37 80 7032 12234 1727435
Gastritis erosive 108.45 45.37 36 7076 931 1738738
Haemodynamic instability 104.44 45.37 38 7074 1299 1738370
Blood pressure decreased 103.97 45.37 65 7047 7581 1732088
Mallory-Weiss syndrome 101.99 45.37 27 7085 307 1739362
Dysarthria 101.25 45.37 56 7056 5203 1734466
Haemobilia 98.43 45.37 21 7091 83 1739586
Presyncope 97.30 45.37 44 7068 2654 1737015
Prescribed underdose 96.39 45.37 37 7075 1471 1738198
Respiratory tract haemorrhage 94.25 45.37 21 7091 106 1739563
Abdominal pain 93.29 45.37 93 7019 21397 1718272
General physical health deterioration 93.18 45.37 75 7037 13043 1726626
Renal failure 93.18 45.37 90 7022 19927 1719742
Pruritus 92.63 45.37 96 7016 23126 1716543
Cardiac failure 91.53 45.37 73 7039 12529 1727140
Abdominal pain upper 91.37 45.37 69 7043 10932 1728737
Petechiae 91.09 45.37 36 7076 1549 1738120
Kounis syndrome 90.32 45.37 26 7086 411 1739258
Microcytic anaemia 89.46 45.37 25 7087 353 1739316
Coronary artery occlusion 88.46 45.37 38 7074 2025 1737644
Cardiogenic shock 88.42 45.37 40 7072 2414 1737255
Hyphaema 87.90 45.37 19 7093 81 1739588
Extradural haematoma 87.32 45.37 23 7089 256 1739413
Purpura 87.16 45.37 36 7076 1738 1737931
Procedural haemorrhage 85.88 45.37 25 7087 412 1739257
Ischaemic stroke 83.90 45.37 42 7070 3180 1736489
Pulmonary haematoma 83.87 45.37 15 7097 15 1739654
Acute coronary syndrome 83.63 45.37 38 7074 2317 1737352
Confusional state 83.11 45.37 87 7025 21191 1718478
Haemothorax 82.41 45.37 27 7085 669 1739000
Acquired haemophilia 82.08 45.37 20 7092 158 1739511
Polyarthritis 80.98 45.37 25 7087 508 1739161
Ventricular fibrillation 80.94 45.37 39 7073 2717 1736952
Contusion 79.46 45.37 48 7064 5261 1734408
Oesophagitis 78.46 45.37 33 7079 1668 1738001
Condition aggravated 78.20 45.37 84 7028 21066 1718603
Abdominal tenderness 77.90 45.37 25 7087 579 1739090
Wound haemorrhage 77.43 45.37 22 7090 331 1739338
Haemorrhagic stroke 73.71 45.37 29 7083 1232 1738437
Vitreous haemorrhage 73.12 45.37 23 7089 498 1739171
Vascular stent stenosis 72.92 45.37 19 7093 202 1739467
Atrial fibrillation 72.27 45.37 69 7043 15042 1724627
Duodenitis 72.12 45.37 24 7088 625 1739044
Haemorrhagic ascites 71.63 45.37 15 7097 53 1739616
Product substitution issue 71.60 45.37 38 7074 3248 1736421
Hypertension 71.46 45.37 77 7035 19371 1720298
Dyspnoea exertional 71.12 45.37 41 7071 4120 1735549
Angina unstable 70.92 45.37 33 7079 2125 1737544
Electrocardiogram ST segment elevation 70.86 45.37 26 7086 910 1738759
Long QT syndrome 70.50 45.37 20 7092 299 1739370
Pallor 70.27 45.37 38 7074 3373 1736296
Cerebrovascular accident 69.64 45.37 73 7039 17793 1721876
Cardiac ventricular thrombosis 69.57 45.37 17 7095 136 1739533
Off label use 67.83 45.37 106 7006 38465 1701204
Mouth haemorrhage 67.67 45.37 25 7087 892 1738777
Coronary artery thrombosis 67.11 45.37 22 7090 546 1739123
Acute kidney injury 67.04 45.37 100 7012 34844 1704825
Diverticulum intestinal haemorrhagic 65.61 45.37 19 7093 307 1739362
Retroperitoneal haemorrhage 65.53 45.37 21 7091 484 1739185
Nausea 65.37 45.37 122 6990 51074 1688595
Cerebral haematoma 65.05 45.37 23 7089 722 1738947
Vomiting 64.20 45.37 103 7009 38212 1701457
Coronary artery stenosis 64.09 45.37 28 7084 1554 1738115
Peripheral artery stenosis 63.90 45.37 16 7096 143 1739526
Spontaneous haemorrhage 63.45 45.37 13 7099 40 1739629
Coronary artery disease 62.98 45.37 53 7059 9793 1729876
Hemiplegia 61.75 45.37 26 7086 1317 1738352
Haemorrhagic transformation stroke 61.47 45.37 18 7094 303 1739366
Haemorrhage subcutaneous 61.37 45.37 20 7092 487 1739182
Head injury 60.38 45.37 33 7079 2991 1736678
Ulcer haemorrhage 60.20 45.37 19 7093 416 1739253
Aorta hypoplasia 59.84 45.37 12 7100 32 1739637
Erythema 58.93 45.37 60 7052 14128 1725541
Gastric ulcer haemorrhage 58.48 45.37 23 7089 976 1738693
Bleeding time prolonged 57.86 45.37 15 7097 156 1739513
Rash 56.75 45.37 98 7014 38595 1701074
Medication error 56.21 45.37 37 7075 4706 1734963
Intra-abdominal haematoma 56.17 45.37 16 7096 243 1739426
Vertigo 56.16 45.37 36 7076 4377 1735292
Gingival bleeding 55.97 45.37 24 7088 1272 1738397
Shone complex 55.91 45.37 10 7102 10 1739659
Benign gastrointestinal neoplasm 55.91 45.37 10 7102 10 1739659
Pulmonary haemorrhage 55.88 45.37 26 7086 1673 1737996
Multiple organ dysfunction syndrome 55.53 45.37 48 7064 9194 1730475
Brain oedema 55.32 45.37 28 7084 2168 1737501
Small intestinal haemorrhage 54.80 45.37 17 7095 351 1739318
Supravalvular aortic stenosis 54.75 45.37 9 7103 2 1739667
Spinal epidural haematoma 54.46 45.37 12 7100 57 1739612
Pericardial effusion 54.22 45.37 32 7080 3358 1736311
Circulatory collapse 53.55 45.37 32 7080 3435 1736234
Abdominal wall haematoma 53.38 45.37 16 7096 293 1739376
Transfusion 52.57 45.37 22 7090 1097 1738572
Chest discomfort 52.18 45.37 42 7070 7289 1732380
Cholestasis 51.91 45.37 32 7080 3633 1736036
Coagulopathy 51.82 45.37 29 7083 2752 1736917
Diverticulum 51.40 45.37 21 7091 985 1738684
Spontaneous haematoma 51.26 45.37 13 7099 123 1739546
Splenic rupture 50.88 45.37 16 7096 346 1739323
Spinal subarachnoid haemorrhage 50.83 45.37 9 7103 8 1739661
Haemorrhage urinary tract 50.24 45.37 16 7096 361 1739308
Product prescribing error 50.05 45.37 27 7085 2383 1737286
Device occlusion 49.69 45.37 20 7092 902 1738767
Oesophageal ulcer 49.26 45.37 18 7094 622 1739047
Oedema peripheral 49.24 45.37 57 7055 15493 1724176
Fat embolism 49.22 45.37 12 7100 95 1739574
Post procedural haematoma 48.85 45.37 15 7097 299 1739370
Blood creatinine increased 47.33 45.37 53 7059 13893 1725776
Product odour abnormal 47.19 45.37 14 7098 247 1739422
Facial paralysis 47.01 45.37 24 7088 1892 1737777
Blood urea increased 46.90 45.37 33 7079 4678 1734991
Hydrocephalus 46.87 45.37 19 7093 873 1738796
Respiratory distress 46.47 45.37 34 7078 5123 1734546
Ventricular tachycardia 45.90 45.37 30 7082 3768 1735901
Mitral valve hypoplasia 45.80 45.37 8 7104 6 1739663

Pharmacologic Action:

SourceCodeDescription
ATC B01AC04 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
CHEBI has role CHEBI:50427 platelet aggregation inhibitor
CHEBI has role CHEBI:50249 anticoagulant
MeSH PA D006401 Hematologic Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D058914 Purinergic Antagonists
MeSH PA D058919 Purinergic P2 Receptor Antagonists
MeSH PA D058921 Purinergic P2Y Receptor Antagonists
FDA PE N0000008832 Decreased Platelet Aggregation
FDA EPC N0000182142 P2Y12 Platelet Inhibitor
FDA MoA N0000182143 P2Y12 Receptor Antagonists
FDA MoA N0000187062 Cytochrome P450 2C8 Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Cerebral embolism indication 75543006 DOID:4372
Non-Q wave myocardial infarction indication 314207007
Acute coronary syndrome indication 394659003
Acute ST segment elevation myocardial infarction indication 401303003
Myocardial Reinfarction Prevention indication
Peripheral Arterial Thromboembolism Prevention indication
Intracranial hemorrhage contraindication 1386000
Acute hemorrhage contraindication 8573003
Retinal hemorrhage contraindication 28998008
Gastrointestinal ulcer contraindication 40845000
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Acute hepatic failure contraindication 197270009
Surgical procedure contraindication 387713003
Traumatic injury contraindication 417746004
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
P2Y purinoceptor 12 GPCR ANTAGONIST Ki 6.90 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.52 DRUG MATRIX
Cytochrome P450 2B6 Enzyme Ki 6.30 WOMBAT-PK

External reference:

IDSource
D000077144 MESH_DESCRIPTOR_UI
4024096 VUID
N0000022101 NUI
C0070166 UMLSCUI
D00769 KEGG_DRUG
08I79HTP27 UNII
120202-66-6 SECONDARY_CAS_RN
108979001 SNOMEDCT_US
4024096 VANDF
007363 NDDF
d04258 MMSL
4480 MMSL
32968 RXNORM
386952008 SNOMEDCT_US
5908 INN_ID
DB00758 DRUGBANK_ID
CHEMBL1771 ChEMBL_ID
CHEMBL1083385 ChEMBL_ID
CGE PDB_CHEM_ID
CHEBI:37941 CHEBI
7150 IUPHAR_LIGAND_ID
60606 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0093-7314 TABLET, FILM COATED 75 mg ORAL ANDA 18 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0615-7719 TABLET, FILM COATED 75 mg ORAL ANDA 19 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0615-8014 TABLET, FILM COATED 75 mg ORAL ANDA 18 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6294 TABLET 75 mg ORAL ANDA 18 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0904-6467 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 13668-141 TABLET 75 mg ORAL ANDA 18 sections
PLAVIX HUMAN PRESCRIPTION DRUG LABEL 1 16590-288 TABLET, FILM COATED 75 mg ORAL NDA 12 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 16729-218 TABLET, FILM COATED 75 mg ORAL ANDA 19 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 16729-219 TABLET, FILM COATED 300 mg ORAL ANDA 19 sections
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 21695-665 TABLET, FILM COATED 75 mg ORAL NDA 19 sections
clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 31722-901 TABLET, FILM COATED 75 mg ORAL ANDA 19 sections
clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 31722-902 TABLET, FILM COATED 300 mg ORAL ANDA 19 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 33261-987 TABLET, FILM COATED 75 mg ORAL ANDA 19 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 33342-060 TABLET 75 mg ORAL ANDA 19 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 42543-713 TABLET 75 mg ORAL ANDA 18 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 42543-714 TABLET 300 mg ORAL ANDA 18 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 43063-371 TABLET 75 mg ORAL ANDA 18 sections
clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 43353-269 TABLET, FILM COATED 75 mg ORAL ANDA 20 sections
CLOPIDOGREL HUMAN PRESCRIPTION DRUG LABEL 1 43547-484 TABLET 75 mg ORAL ANDA 18 sections
CLOPIDOGREL HUMAN PRESCRIPTION DRUG LABEL 1 43547-485 TABLET 300 mg ORAL ANDA 18 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 47335-894 TABLET, FILM COATED 75 mg ORAL ANDA 18 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-1300 TABLET, FILM COATED 75 mg ORAL ANDA 18 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 50090-2598 TABLET, FILM COATED 75 mg ORAL ANDA 19 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 50090-4918 TABLET, FILM COATED 75 mg ORAL ANDA 19 sections
Clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 50228-121 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
Clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 50228-124 TABLET, FILM COATED 75 mg ORAL ANDA 18 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 50268-184 TABLET, FILM COATED 300 mg ORAL ANDA 19 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 50436-9986 TABLET, FILM COATED 75 mg ORAL ANDA 19 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 51407-032 TABLET, FILM COATED 75 mg ORAL ANDA 18 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 53002-1672 TABLET, FILM COATED 75 mg ORAL ANDA 18 sections