clopidogrel Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
platelet aggregation inhibitors 708 113665-84-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clopidogrel
  • zyllt
  • clopidogrel bisulfate
  • clopidogrel besilate
  • clopidogrel hydrochloride
  • clopidogrel hydrogen sulphate
  • clopidogrel hydrobromide
  • clopidogrel sulfate
  • clopidogrel HCl
A ticlopidine analog and platelet purinergic P2Y receptor antagonist that inhibits adenosine diphosphate-mediated PLATELET AGGREGATION. It is used to prevent THROMBOEMBOLISM in patients with ARTERIAL OCCLUSIVE DISEASES; MYOCARDIAL INFARCTION; STROKE; or ATRIAL FIBRILLATION.
  • Molecular weight: 321.82
  • Formula: C16H16ClNO2S
  • CLOGP: 4.21
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 29.54
  • ALOGS: -4.43
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.05 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.32 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.01 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 23.65 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.06 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 15, 1998 EMA
Nov. 17, 1997 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1765.48 10.08 1775 134589 95753 46453945
Acute myocardial infarction 978.13 10.08 783 135581 31141 46518557
Gastrointestinal haemorrhage 860.09 10.08 1094 135270 76279 46473419
Cerebrovascular accident 746.39 10.08 1175 135189 99864 46449834
Coronary artery disease 721.44 10.08 674 135690 33078 46516620
Coronary arterial stent insertion 418.81 10.08 192 136172 2661 46547037
Labelled drug-drug interaction medication error 416.67 10.08 284 136080 8777 46540921
Angina pectoris 402.22 10.08 442 135922 26333 46523365
Melaena 342.33 10.08 414 135950 27358 46522340
Transient ischaemic attack 341.59 10.08 464 135900 34439 46515259
Cardiac failure congestive 339.58 10.08 796 135568 90954 46458744
Anaemia 327.75 10.08 1546 134818 254233 46295465
Drug ineffective 327.38 10.08 962 135402 676876 45872822
Haematoma 326.10 10.08 433 135931 31439 46518259
Rheumatoid arthritis 321.34 10.08 150 136214 240065 46309633
Coronary artery occlusion 281.02 10.08 214 136150 7888 46541810
Vascular stent thrombosis 266.05 10.08 99 136265 772 46548926
Cerebral haemorrhage 260.81 10.08 366 135998 28005 46521693
Drug interaction 260.18 10.08 1228 135136 201866 46347832
Acute coronary syndrome 241.75 10.08 216 136148 9988 46539710
Rectal haemorrhage 224.73 10.08 402 135962 37853 46511845
Thrombosis in device 211.54 10.08 123 136241 2856 46546842
Subdural haematoma 208.16 10.08 222 136142 12775 46536923
Haematemesis 208.09 10.08 332 136032 28474 46521224
Completed suicide 206.22 10.08 84 136280 145836 46403862
Angina unstable 205.53 10.08 173 136191 7375 46542323
Stent placement 191.45 10.08 123 136241 3433 46546265
Upper gastrointestinal haemorrhage 190.88 10.08 240 136124 16498 46533200
Treatment failure 187.46 10.08 25 136339 93062 46456636
Chest pain 184.81 10.08 1008 135356 175316 46374382
Vascular pseudoaneurysm 184.32 10.08 87 136277 1293 46548405
Rhabdomyolysis 182.28 10.08 388 135976 41521 46508177
Haemorrhage intracranial 177.23 10.08 202 136162 12522 46537176
Acute kidney injury 176.49 10.08 1236 135128 234619 46315079
Coronary artery stenosis 175.71 10.08 130 136234 4583 46545115
Epistaxis 174.79 10.08 497 135867 63808 46485890
Vascular stent stenosis 172.77 10.08 64 136300 492 46549206
Haemorrhage 170.02 10.08 445 135919 54424 46495274
Maternal exposure during pregnancy 163.88 10.08 48 136316 102501 46447197
Haematochezia 161.76 10.08 346 136018 37147 46512551
Off label use 160.25 10.08 571 135793 379270 46170428
Exposure during pregnancy 153.32 10.08 62 136302 108150 46441548
Shock haemorrhagic 150.07 10.08 154 136210 8470 46541228
Toxicity to various agents 145.31 10.08 247 136117 211519 46338179
Synovitis 142.62 10.08 9 136355 61066 46488632
Drug intolerance 134.01 10.08 139 136225 146910 46402788
Fall 130.70 10.08 1502 134862 327595 46222103
Coronary artery thrombosis 130.15 10.08 65 136299 1100 46548598
Cerebral infarction 126.39 10.08 237 136127 23129 46526569
Drug hypersensitivity 123.54 10.08 337 136027 243488 46306210
Multiple injuries 123.38 10.08 75 136289 1894 46547804
Thrombotic thrombocytopenic purpura 119.82 10.08 96 136268 3814 46545884
Retroperitoneal haemorrhage 119.44 10.08 83 136281 2647 46547051
Infusion related reaction 117.93 10.08 75 136289 101133 46448565
Pyrexia 114.48 10.08 577 135787 348225 46201473
Hyperkalaemia 113.39 10.08 366 135998 50343 46499355
Spinal epidural haematoma 112.43 10.08 52 136312 736 46548962
Syncope 108.87 10.08 598 135766 104205 46445493
Hypoglycaemia 106.28 10.08 375 135989 53974 46495724
Arterial haemorrhage 103.97 10.08 64 136300 1654 46548044
Therapeutic product effect decreased 103.60 10.08 56 136308 82545 46467153
Joint swelling 102.08 10.08 207 136157 165866 46383832
Alopecia 101.93 10.08 200 136164 162214 46387484
Abdominal wall haematoma 101.89 10.08 77 136287 2804 46546894
Systemic lupus erythematosus 101.41 10.08 32 136332 65148 46484550
Pemphigus 99.11 10.08 9 136355 45265 46504433
Subarachnoid haemorrhage 98.21 10.08 141 136223 11012 46538686
Hemiparesis 98.07 10.08 195 136169 19874 46529824
Abortion spontaneous 97.39 10.08 8 136356 43638 46506060
Arteriosclerosis 96.08 10.08 130 136234 9603 46540095
Ecchymosis 95.03 10.08 135 136229 10441 46539257
Pain 93.89 10.08 916 135448 476032 46073666
Extradural haematoma 93.81 10.08 56 136308 1367 46548331
Febrile neutropenia 93.68 10.08 83 136281 94544 46455154
Malignant neoplasm progression 92.26 10.08 37 136327 64889 46484809
Myocardial ischaemia 90.76 10.08 146 136218 12603 46537095
Therapeutic product effect incomplete 88.21 10.08 60 136304 78093 46471605
Hyponatraemia 85.16 10.08 547 135817 100785 46448913
Carotid artery stenosis 84.72 10.08 89 136275 5031 46544667
Drug abuse 83.98 10.08 40 136324 63368 46486330
Lower gastrointestinal haemorrhage 83.51 10.08 105 136259 7215 46542483
Coronary artery bypass 83.50 10.08 64 136300 2381 46547317
Infection 82.51 10.08 166 136198 133426 46416272
Cardiogenic shock 82.23 10.08 161 136203 16223 46533475
Arterial stenosis 80.72 10.08 39 136325 612 46549086
Lactic acidosis 78.76 10.08 248 136116 33661 46516037
Hand deformity 78.08 10.08 6 136358 34568 46515130
Hypotension 77.62 10.08 1028 135336 231561 46318137
Ischaemic stroke 77.56 10.08 159 136205 16563 46533135
Haemoglobin decreased 74.62 10.08 637 135727 128312 46421386
Arthralgia 74.28 10.08 694 135670 363909 46185789
Rash 73.75 10.08 676 135688 355836 46193862
Contraindicated product administered 72.30 10.08 76 136288 79871 46469827
Arterial occlusive disease 71.57 10.08 79 136285 4725 46544973
Ischaemic cardiomyopathy 71.42 10.08 60 136304 2550 46547148
Haemorrhagic stroke 70.22 10.08 84 136280 5482 46544216
Sinusitis 69.72 10.08 174 136190 129594 46420104
Blood loss anaemia 69.30 10.08 104 136260 8453 46541245
Product use issue 68.94 10.08 106 136258 94538 46455160
Headache 67.44 10.08 988 135376 477364 46072334
Cardiac disorder 66.35 10.08 279 136085 43579 46506119
Nasopharyngitis 64.38 10.08 232 136132 153766 46395932
Disease progression 63.90 10.08 105 136259 91195 46458503
Injection site reaction 63.64 10.08 30 136334 47819 46501879
Peripheral arterial occlusive disease 63.47 10.08 66 136298 3686 46546012
Contusion 63.19 10.08 455 135909 87032 46462666
Injection site erythema 62.65 10.08 75 136289 74352 46475346
Peripheral vascular disorder 62.32 10.08 82 136282 5895 46543803
Bradycardia 62.03 10.08 368 135996 65930 46483768
Post procedural haematoma 61.28 10.08 42 136322 1309 46548389
Haemoptysis 61.24 10.08 192 136172 25997 46523701
Fatigue 60.87 10.08 1336 135028 607361 45942337
White blood cell count decreased 59.88 10.08 151 136213 112080 46437618
Product use in unapproved indication 59.37 10.08 108 136256 90165 46459533
Device expulsion 58.89 10.08 6 136358 27536 46522162
Retroperitoneal haematoma 58.82 10.08 54 136310 2586 46547112
Gastritis erosive 58.50 10.08 75 136289 5255 46544443
Pregnancy 57.80 10.08 6 136358 27131 46522567
Coronary artery restenosis 56.56 10.08 27 136337 412 46549286
Intentional overdose 56.21 10.08 64 136300 64880 46484818
Foetal exposure during pregnancy 55.73 10.08 11 136353 30736 46518962
Eosinophilic bronchitis 52.89 10.08 23 136341 279 46549419
Glossodynia 52.88 10.08 32 136332 44341 46505357
Arthropathy 49.13 10.08 109 136255 84591 46465107
Asthenia 48.19 10.08 1219 135145 309856 46239842
Kidney rupture 48.06 10.08 13 136351 28 46549670
Rheumatoid factor positive 47.80 10.08 3 136361 20458 46529240
Confusional state 47.31 10.08 692 135672 159200 46390498
Brain herniation 47.28 10.08 51 136313 2972 46546726
Atrial fibrillation 47.01 10.08 486 135878 103104 46446594
Hypersensitivity 46.73 10.08 253 136111 150068 46399630
Peripheral ischaemia 46.69 10.08 62 136302 4497 46545201
Device occlusion 46.36 10.08 71 136293 5874 46543824
Internal haemorrhage 46.26 10.08 61 136303 4394 46545304
Musculoskeletal stiffness 46.19 10.08 140 136224 97853 46451845
Peripheral artery stenosis 45.88 10.08 25 136339 510 46549188
Oesophageal intramural haematoma 45.76 10.08 15 136349 76 46549622
Product administration error 45.75 10.08 144 136220 19537 46530161
Injection site pain 45.71 10.08 160 136204 106992 46442706
Abdominal discomfort 45.58 10.08 257 136107 150908 46398790
Intentional self-injury 45.18 10.08 8 136356 24158 46525540
Angioplasty 45.11 10.08 34 136330 1233 46548465
Coronary artery dissection 45.08 10.08 27 136337 663 46549035
Psoriasis 44.90 10.08 102 136262 78502 46471196
Post procedural haemorrhage 44.82 10.08 79 136285 7347 46542351
Renal failure 44.23 10.08 517 135847 113077 46436621
Coma scale abnormal 43.65 10.08 63 136301 4943 46544755
Haematuria 43.09 10.08 174 136190 26684 46523014
Dysarthria 43.01 10.08 220 136144 37278 46512420
Subarachnoid haematoma 42.53 10.08 10 136354 8 46549690
Psoriatic arthropathy 42.29 10.08 27 136337 36352 46513346
Nausea 42.26 10.08 1613 134751 685841 45863857
Pallor 42.00 10.08 156 136208 23010 46526688
Migraine 41.53 10.08 89 136275 69937 46479761
Duodenal ulcer 41.27 10.08 75 136289 7143 46542555
Traumatic haematoma 41.26 10.08 34 136330 1406 46548292
Lymphocyte count decreased 40.81 10.08 12 136352 25577 46524121
Arteriosclerosis coronary artery 39.54 10.08 79 136285 8077 46541621
Periorbital haematoma 39.19 10.08 26 136338 767 46548931
Diverticulum intestinal haemorrhagic 39.12 10.08 31 136333 1212 46548486
Intermittent claudication 38.18 10.08 36 136328 1784 46547914
Suicide attempt 37.84 10.08 64 136300 54972 46494726
C-reactive protein abnormal 37.74 10.08 8 136356 21262 46528436
Endothelial dysfunction 37.53 10.08 14 136350 110 46549588
Aortic arteriosclerosis 37.33 10.08 63 136301 5658 46544040
Cardiac tamponade 37.31 10.08 55 136309 4399 46545299
Procedural haemorrhage 36.87 10.08 40 136324 2346 46547352
Vascular graft 36.82 10.08 25 136339 767 46548931
Suicidal ideation 36.57 10.08 68 136296 56314 46493384
Diarrhoea 36.34 10.08 1304 135060 558298 45991400
Gastrointestinal tract mucosal pigmentation 36.10 10.08 22 136342 558 46549140
Electrocardiogram ST segment elevation 35.93 10.08 49 136315 3646 46546052
Mitral valve incompetence 35.90 10.08 129 136235 18723 46530975
Ventricular fibrillation 35.33 10.08 93 136271 11403 46538295
Pemphigoid 34.94 10.08 61 136303 5630 46544068
Loss of personal independence in daily activities 34.47 10.08 72 136292 57111 46492587
Carotid arteriosclerosis 34.23 10.08 26 136338 954 46548744
Muscle haemorrhage 33.94 10.08 45 136319 3259 46546439
Diverticulum intestinal 33.57 10.08 62 136302 5979 46543719
Labile hypertension 33.51 10.08 20 136344 488 46549210
Carotid artery occlusion 33.33 10.08 40 136324 2619 46547079
Hepatic enzyme increased 32.98 10.08 125 136239 81662 46468036
Tachyarrhythmia 32.90 10.08 53 136311 4579 46545119
Head injury 32.90 10.08 151 136213 24485 46525213
Cardiovascular disorder 32.89 10.08 94 136270 12093 46537605
Intracardiac thrombus 32.74 10.08 37 136327 2271 46547427
Haemarthrosis 32.67 10.08 42 136322 2951 46546747
Puncture site haemorrhage 32.29 10.08 16 136348 266 46549432
Gastric ulcer haemorrhage 32.28 10.08 54 136310 4814 46544884
Gastric haemorrhage 31.85 10.08 60 136304 5874 46543824
Cerebral ischaemia 31.55 10.08 62 136302 6263 46543435
Abnormal loss of weight 31.42 10.08 54 136310 4921 46544777
Blood creatine phosphokinase increased 31.34 10.08 162 136202 27562 46522136
Weight increased 31.30 10.08 318 136046 164155 46385543
Faeces discoloured 31.23 10.08 114 136250 16673 46533025
Swelling 31.20 10.08 224 136140 124287 46425411
Cardiac failure 31.16 10.08 364 136000 79584 46470114
Mucosal inflammation 30.99 10.08 41 136323 38935 46510763
Coronary angioplasty 30.85 10.08 12 136352 107 46549591
Peripheral artery occlusion 30.83 10.08 26 136338 1111 46548587
Subdural haemorrhage 30.44 10.08 40 136324 2872 46546826
Microcytic anaemia 30.00 10.08 41 136323 3057 46546641
International normalised ratio increased 29.98 10.08 237 136127 46646 46503052
Hip arthroplasty 29.80 10.08 8 136356 18104 46531594
Injection site swelling 29.51 10.08 45 136319 40282 46509416
Medication error 29.17 10.08 172 136192 30739 46518959
Gastritis 29.10 10.08 186 136178 34192 46515506
Neutropenia 28.87 10.08 273 136091 142931 46406767
Acne 28.87 10.08 11 136353 19908 46529790
Heparin-induced thrombocytopenia 28.84 10.08 48 136316 4261 46545437
Skin weeping 28.46 10.08 14 136350 229 46549469
Gastric ulcer 28.46 10.08 133 136231 21730 46527968
Coronary artery reocclusion 28.42 10.08 9 136355 40 46549658
Intestinal haemorrhage 28.40 10.08 40 136324 3068 46546630
Catheter site haematoma 28.39 10.08 12 136352 135 46549563
Condition aggravated 28.17 10.08 525 135839 244527 46305171
Intentional product use issue 28.14 10.08 71 136293 52709 46496989
Multiple sclerosis relapse 28.04 10.08 50 136314 42075 46507623
Herpes zoster 27.84 10.08 103 136261 67769 46481929
Neutrophil count decreased 27.61 10.08 53 136311 43373 46506325
Injection site pruritus 27.52 10.08 46 136318 39697 46510001
Angioedema 27.46 10.08 203 136161 39139 46510559
Percutaneous coronary intervention 27.34 10.08 12 136352 149 46549549
Flushing 27.20 10.08 97 136267 64517 46485181
Eye haemorrhage 26.93 10.08 62 136302 6990 46542708
Bladder sphincter atony 26.92 10.08 12 136352 155 46549543
Platelet function test abnormal 26.87 10.08 10 136354 78 46549620
Traumatic intracranial haemorrhage 26.84 10.08 15 136349 322 46549376
Ischaemic cerebral infarction 26.84 10.08 25 136339 1220 46548478
Asthma 26.84 10.08 157 136207 91385 46458313
Hiatus hernia 26.57 10.08 115 136249 18187 46531511
Acute pulmonary oedema 26.49 10.08 66 136298 7825 46541873
Chills 26.43 10.08 168 136196 95864 46453834
Premature baby 26.25 10.08 10 136354 18102 46531596
Neuropathy peripheral 26.06 10.08 157 136207 90736 46458962
Plasma cell myeloma 25.98 10.08 57 136307 44421 46505277
Chronic kidney disease 25.80 10.08 206 136158 40665 46509033
Pericardial haemorrhage 25.73 10.08 27 136337 1524 46548174
Hemiplegia 25.40 10.08 60 136304 6878 46542820
Dyspnoea 25.39 10.08 1789 134575 513759 46035939
Lymphatic fistula 25.31 10.08 21 136343 877 46548821
Aortic aneurysm 25.28 10.08 40 136324 3404 46546294
Stomatitis 25.25 10.08 108 136256 68189 46481509
Liver function test increased 25.11 10.08 18 136346 22808 46526890
Orthostatic hypotension 25.09 10.08 140 136224 24518 46525180
Femoral hernia incarcerated 25.09 10.08 21 136343 888 46548810
General physical health deterioration 24.98 10.08 476 135888 115293 46434405
Pericarditis 24.87 10.08 20 136344 23907 46525791
Cerebral haematoma 24.81 10.08 39 136325 3300 46546398
Cerebral hyperperfusion syndrome 24.48 10.08 7 136357 20 46549678
Device inappropriate shock delivery 24.41 10.08 6 136358 7 46549691
Rectosigmoid cancer 24.41 10.08 11 136353 146 46549552
Caesarean section 24.34 10.08 9 136355 16594 46533104
Capillary fragility test 24.23 10.08 7 136357 21 46549677
Tricuspid valve incompetence 23.73 10.08 91 136273 13626 46536072
Ocular retrobulbar haemorrhage 23.72 10.08 8 136356 45 46549653
Cerebellar haemorrhage 23.61 10.08 24 136340 1305 46548393
Lacunar infarction 23.57 10.08 39 136325 3446 46546252
Arterial thrombosis 23.38 10.08 24 136340 1320 46548378
Pancreatic steatosis 23.26 10.08 21 136343 984 46548714
Spinal subdural haematoma 23.24 10.08 10 136354 118 46549580
Metastases to bone 23.17 10.08 11 136353 17465 46532233
Spinal cord haemorrhage 23.15 10.08 11 136353 166 46549532
Breast cancer 22.92 10.08 63 136301 45455 46504243
Atrioventricular block 22.90 10.08 57 136307 6754 46542944
Coronary artery perforation 22.89 10.08 7 136357 27 46549671
Intraventricular haemorrhage 22.81 10.08 28 136336 1877 46547821
Oedema peripheral 22.67 10.08 619 135745 159087 46390611
Dermatitis exfoliative 22.65 10.08 51 136313 5665 46544033
Influenza 22.64 10.08 160 136204 89110 46460588
Renal artery stenosis 22.58 10.08 27 136337 1761 46547937
No adverse event 22.45 10.08 41 136323 34190 46515508
Arthritis 22.45 10.08 133 136231 77183 46472515
Dizziness 22.44 10.08 1212 135152 339202 46210496
Oropharyngeal pain 22.38 10.08 126 136238 74042 46475656
Premature delivery 22.26 10.08 19 136345 22050 46527648
Tachycardia 22.24 10.08 185 136179 99437 46450261
Troponin increased 21.79 10.08 61 136303 7755 46541943
Hepatic cyst 21.72 10.08 45 136319 4721 46544977
Product dose omission issue 21.60 10.08 354 136010 168166 46381532
Diabetes mellitus inadequate control 21.51 10.08 86 136278 13128 46536570
Postinfarction angina 21.43 10.08 7 136357 35 46549663
Chronic obstructive pulmonary disease 21.39 10.08 260 136104 57373 46492325
Palmar-plantar erythrodysaesthesia syndrome 21.38 10.08 17 136347 20434 46529264
Blood glucose increased 21.00 10.08 311 136053 71702 46477996
Posterior reversible encephalopathy syndrome 20.90 10.08 9 136355 15132 46534566
Tongue oedema 20.87 10.08 40 136324 3966 46545732
Neurotoxicity 20.86 10.08 7 136357 13710 46535988
Large intestinal haemorrhage 20.85 10.08 21 136343 1129 46548569
Knee arthroplasty 20.82 10.08 23 136341 23642 46526056
Therapeutic response decreased 20.78 10.08 61 136303 43084 46506614
Myalgia 20.69 10.08 488 135876 122600 46427098
Cardiac procedure complication 20.65 10.08 11 136353 214 46549484
Fungal infection 20.59 10.08 34 136330 29486 46520212
Premature labour 20.57 10.08 4 136360 11295 46538403
Product prescribing error 20.52 10.08 114 136250 19933 46529765
Lichen nitidus 20.50 10.08 8 136356 72 46549626
Arterial injury 20.47 10.08 10 136354 161 46549537
Respiratory tract infection 20.47 10.08 35 136329 29937 46519761
Hypertensive heart disease 20.40 10.08 31 136333 2547 46547151
Coronary ostial stenosis 20.31 10.08 8 136356 74 46549624
Amblyopia 20.29 10.08 11 136353 222 46549476
Respiratory tract haemorrhage 20.29 10.08 13 136351 361 46549337
Coagulation time prolonged 20.25 10.08 22 136342 1292 46548406
Live birth 20.25 10.08 3 136361 10327 46539371
Wound infection pseudomonas 20.09 10.08 23 136341 1432 46548266
Bone marrow failure 19.94 10.08 35 136329 29634 46520064
Loss of consciousness 19.71 10.08 434 135930 107804 46441894
Resuscitation 19.50 10.08 20 136344 1099 46548599
Petechiae 19.46 10.08 81 136283 12589 46537109
Contrast encephalopathy 19.46 10.08 7 136357 49 46549649
Cardiac death 19.34 10.08 15 136349 568 46549130
Acute myeloid leukaemia 19.33 10.08 11 136353 15767 46533931
Neoplasm progression 19.31 10.08 30 136334 26653 46523045
Vessel puncture site haematoma 19.29 10.08 9 136355 130 46549568
Oesophageal mucosal dissection 19.25 10.08 6 136358 25 46549673
Death 19.25 10.08 793 135571 334755 46214943
Product odour abnormal 19.25 10.08 20 136344 1116 46548582
Blood creatine phosphokinase MB increased 19.24 10.08 21 136343 1240 46548458
Hot flush 19.21 10.08 64 136300 43453 46506245
Haemorrhoidal haemorrhage 19.21 10.08 37 136327 3683 46546015
Device issue 19.19 10.08 18 136346 19962 46529736
Adverse drug reaction 19.07 10.08 66 136298 44296 46505402
Metastases to lung 19.02 10.08 4 136360 10692 46539006
Red blood cell sedimentation rate abnormal 19.02 10.08 8 136356 13641 46536057
Low density lipoprotein increased 18.91 10.08 49 136315 5951 46543747
Sciatic nerve palsy 18.88 10.08 6 136358 27 46549671
Toxic skin eruption 18.88 10.08 79 136285 12308 46537390
Atrioventricular block complete 18.83 10.08 57 136307 7570 46542128
Acid base balance abnormal 18.78 10.08 11 136353 259 46549439
Insomnia 18.73 10.08 354 136010 164570 46385128
Fibromyalgia 18.71 10.08 50 136314 36413 46513285
Acute left ventricular failure 18.66 10.08 17 136347 806 46548892
Pneumonia 18.60 10.08 904 135460 375416 46174282
Iliac artery occlusion 18.58 10.08 9 136355 142 46549556
Aortic valve stenosis 18.55 10.08 33 136331 3091 46546607
Gastrointestinal angiodysplasia 18.50 10.08 13 136351 422 46549276
Joint effusion 18.45 10.08 6 136358 11989 46537709
Coagulation factor increased 18.41 10.08 5 136359 11 46549687
Cardiac stress test abnormal 18.40 10.08 15 136349 611 46549087
Hepatorenal failure 18.40 10.08 15 136349 611 46549087
Injection site urticaria 18.38 10.08 6 136358 11961 46537737
Peripheral swelling 18.35 10.08 338 136026 157733 46391965
Device dislocation 18.31 10.08 22 136342 21780 46527918
Catheterisation cardiac 18.20 10.08 38 136326 4009 46545689
Vascular occlusion 18.14 10.08 17 136347 836 46548862
Ischaemia 18.12 10.08 40 136324 4384 46545314
Administration site discomfort 18.11 10.08 8 136356 101 46549597
Presyncope 18.11 10.08 128 136236 24326 46525372
Drug dependence 17.89 10.08 19 136345 19882 46529816
Cytomegalovirus infection 17.84 10.08 16 136348 18128 46531570
Lipoprotein (a) increased 17.75 10.08 6 136358 34 46549664
Cerebrovascular disorder 17.74 10.08 31 136333 2863 46546835
Circulatory collapse 17.69 10.08 116 136248 21508 46528190
Facial paralysis 17.53 10.08 81 136283 13169 46536529
Facial nerve disorder 17.45 10.08 14 136350 557 46549141
Pituitary apoplexy 17.44 10.08 8 136356 111 46549587
Hepatotoxicity 17.26 10.08 29 136335 24980 46524718
Carotid artery disease 17.22 10.08 23 136341 1678 46548020
Compartment syndrome 17.20 10.08 25 136339 1974 46547724
Interstitial lung disease 17.19 10.08 90 136274 53859 46495839
Upper respiratory tract infection 17.07 10.08 112 136252 63444 46486254
Haemothorax 16.96 10.08 25 136339 1999 46547699
Drug withdrawal syndrome 16.91 10.08 34 136330 27350 46522348
C-reactive protein increased 16.89 10.08 101 136263 58489 46491209
Tongue haematoma 16.70 10.08 7 136357 77 46549621
Sepsis 16.68 10.08 288 136076 135726 46413972
Occult blood positive 16.62 10.08 34 136330 3536 46546162
Catheter site haemorrhage 16.58 10.08 29 136335 2680 46547018
Small intestinal haemorrhage 16.44 10.08 24 136340 1902 46547796
Groin pain 16.39 10.08 61 136303 9004 46540694
Pulmonary alveolar haemorrhage 16.34 10.08 37 136327 4125 46545573
Mucosal membrane hyperplasia 16.32 10.08 6 136358 45 46549653
Injection site warmth 16.31 10.08 10 136354 13762 46535936
Device related thrombosis 16.28 10.08 19 136345 1208 46548490
Pulseless electrical activity 16.25 10.08 52 136312 7115 46542583
Diabetic macroangiopathy 16.09 10.08 8 136356 134 46549564
Tuberculosis 16.03 10.08 5 136359 10260 46539438
Angiocardiogram 15.99 10.08 6 136358 48 46549650
Nephrosclerosis 15.95 10.08 17 136347 977 46548721
Diverticulum 15.95 10.08 70 136294 11136 46538562
Macroangiopathy 15.94 10.08 7 136357 87 46549611
Aphasia 15.90 10.08 140 136224 28427 46521271
Neutrophilia 15.85 10.08 30 136334 2947 46546751
Night sweats 15.85 10.08 35 136329 27215 46522483
Arterial restenosis 15.83 10.08 5 136359 22 46549676
Osteoporosis 15.76 10.08 63 136301 40545 46509153
Anal haemorrhage 15.74 10.08 21 136343 1530 46548168
Erosive oesophagitis 15.73 10.08 22 136342 1676 46548022
Brain compression 15.69 10.08 11 136353 356 46549342
Lymphadenopathy 15.65 10.08 48 136316 33440 46516258
Arterial stent insertion 15.65 10.08 5 136359 23 46549675
Intentional product misuse 15.36 10.08 78 136286 47050 46502648
Paraplegia 15.14 10.08 26 136338 2368 46547330
Eosinophil count increased 15.13 10.08 54 136310 7812 46541886
Constipation 15.08 10.08 390 135974 173707 46375991
Nephrogenic systemic fibrosis 15.07 10.08 39 136325 4733 46544965
Mucosal haemorrhage 15.04 10.08 15 136349 797 46548901
Pulmonary oedema 15.01 10.08 221 136143 50884 46498814
Choroidal haemorrhage 15 10.08 6 136358 58 46549640
Metastases to central nervous system 14.97 10.08 7 136357 11214 46538484
Pulmonary embolism 14.95 10.08 225 136139 108360 46441338
Kounis syndrome 14.93 10.08 18 136346 1184 46548514
Hypercholesterolaemia 14.90 10.08 70 136294 11460 46538238
Immunodeficiency 14.86 10.08 10 136354 13096 46536602
Chest expansion decreased 14.84 10.08 5 136359 28 46549670
Anal stenosis 14.81 10.08 10 136354 304 46549394
Drop attacks 14.79 10.08 14 136350 697 46549001
Discomfort 14.78 10.08 78 136286 46592 46503106
Thrombosis 14.76 10.08 238 136126 55831 46493867
Spinal cord compression 14.74 10.08 33 136331 3651 46546047
Eyelid retraction 14.73 10.08 6 136358 61 46549637
Parkinsonian rest tremor 14.71 10.08 7 136357 106 46549592
Influenza like illness 14.68 10.08 103 136261 57467 46492231
Peripheral artery thrombosis 14.67 10.08 22 136342 1787 46547911
Swollen tongue 14.62 10.08 140 136224 29092 46520606
Haemorrhagic diathesis 14.60 10.08 33 136331 3675 46546023
Obstructive shock 14.55 10.08 5 136359 30 46549668
Mastocytic enterocolitis 14.52 10.08 3 136361 0 46549698
Malabsorption from application site 14.52 10.08 3 136361 0 46549698
Hypothrombinaemia 14.52 10.08 3 136361 0 46549698
Gastrointestinal disorder 14.51 10.08 108 136256 59468 46490230
Iron deficiency anaemia 14.50 10.08 93 136271 17113 46532585
Ventricular tachycardia 14.48 10.08 92 136272 16875 46532823
Binocular eye movement disorder 14.41 10.08 5 136359 31 46549667
Intracranial aneurysm 14.40 10.08 30 136334 3160 46546538
Cardiac operation 14.36 10.08 27 136337 2639 46547059
Sensorimotor disorder 14.31 10.08 11 136353 411 46549287
Arterial disorder 14.30 10.08 17 136347 1102 46548596
Mouth haemorrhage 14.28 10.08 46 136318 6316 46543382
Electrocardiogram ST segment depression 14.17 10.08 27 136337 2666 46547032
Urinary straining 14.15 10.08 5 136359 33 46549665
Vascular stent insertion 14.10 10.08 4 136360 11 46549687
Left ventricular hypertrophy 14.10 10.08 39 136325 4924 46544774
Tongue haemorrhage 14.08 10.08 11 136353 421 46549277
Blood glucose decreased 14.05 10.08 99 136265 18793 46530905
Myocardial necrosis marker increased 13.98 10.08 20 136344 1556 46548142
Device related infection 13.98 10.08 25 136339 21016 46528682
Left ventricular failure 13.96 10.08 39 136325 4951 46544747
Drug-induced liver injury 13.96 10.08 124 136240 25244 46524454
Cerebellar ischaemia 13.90 10.08 5 136359 35 46549663
Ocular icterus 13.89 10.08 32 136332 3608 46546090
Vaginal haematoma 13.88 10.08 7 136357 121 46549577
Ulcer haemorrhage 13.87 10.08 31 136333 3427 46546271
Brown-Sequard syndrome 13.85 10.08 4 136360 12 46549686
Dilatation ventricular 13.83 10.08 26 136338 2541 46547157
Pneumonitis 13.81 10.08 40 136324 28380 46521318
Duodenal ulcer haemorrhage 13.74 10.08 25 136339 2383 46547315
Quadriparesis 13.66 10.08 21 136343 1743 46547955
Brain contusion 13.63 10.08 12 136352 544 46549154
Arteriogram coronary abnormal 13.61 10.08 4 136360 13 46549685
Foot deformity 13.56 10.08 15 136349 15410 46534288
Neutrophil count increased 13.50 10.08 13 136351 14240 46535458
Akathisia 13.48 10.08 3 136361 7711 46541987
Coronary artery embolism 13.45 10.08 8 136356 194 46549504
Anal prolapse 13.43 10.08 7 136357 130 46549568
Emphysematous cystitis 13.43 10.08 7 136357 130 46549568
Implant site haematoma 13.43 10.08 6 136358 78 46549620
Ascites 13.43 10.08 58 136306 36526 46513172
Symmetrical drug-related intertriginous and flexural exanthema 13.35 10.08 9 136355 273 46549425
Myocardial rupture 13.29 10.08 6 136358 80 46549618
Abscess neck 13.28 10.08 12 136352 563 46549135
Coagulation time abnormal 13.23 10.08 6 136358 81 46549617
Gastrointestinal arteriovenous malformation 13.21 10.08 12 136352 567 46549131
Ovarian cyst 13.17 10.08 13 136351 14074 46535624
Exsanguination 13.17 10.08 4 136360 15 46549683
Muscle abscess 13.16 10.08 10 136354 367 46549331
Haemophagocytic lymphohistiocytosis 13.14 10.08 4 136360 8338 46541360
Overdose 13.13 10.08 214 136150 101765 46447933
Ear infection 13.02 10.08 30 136334 22983 46526715
Device breakage 13.00 10.08 6 136358 9686 46540012
Soft tissue haemorrhage 12.85 10.08 8 136356 211 46549487
Mediastinal haematoma 12.84 10.08 6 136358 87 46549611
Physical disability 12.83 10.08 21 136343 1839 46547859
Ejection fraction decreased 12.77 10.08 93 136271 17844 46531854
Amenorrhoea 12.74 10.08 5 136359 8890 46540808
Haemorrhage subcutaneous 12.73 10.08 27 136337 2879 46546819
Malignant melanoma 12.73 10.08 7 136357 10227 46539471
Depression 12.70 10.08 389 135975 169715 46379983
Urine output decreased 12.65 10.08 65 136299 11032 46538666
Microangiopathy 12.65 10.08 14 136350 840 46548858
Joint stiffness 12.57 10.08 39 136325 27069 46522629
Product substitution issue 12.52 10.08 81 136283 14950 46534748
Injection site induration 12.50 10.08 4 136360 8075 46541623
Lacunar stroke 12.43 10.08 6 136358 94 46549604
Platelet dysfunction 12.43 10.08 6 136358 94 46549604
Hypoglycaemic unconsciousness 12.40 10.08 13 136351 733 46548965
Foetal death 12.39 10.08 5 136359 8738 46540960
Anuria 12.37 10.08 66 136298 11365 46538333
Bundle branch block left 12.36 10.08 44 136320 6355 46543343
Carotid bruit 12.36 10.08 13 136351 736 46548962
Atrial thrombosis 12.34 10.08 18 136346 1426 46548272
Gastrointestinal vascular malformation haemorrhagic 12.25 10.08 7 136357 157 46549541
Myoglobinaemia 12.25 10.08 4 136360 20 46549678
Change of bowel habit 12.25 10.08 20 136344 1748 46547950
Lymphopenia 12.25 10.08 16 136348 15277 46534421
Skull fracture 12.22 10.08 14 136350 872 46548826
Vascular graft occlusion 12.13 10.08 7 136357 160 46549538
Incision site haemorrhage 12.12 10.08 11 136353 519 46549179
Sedation 12.07 10.08 31 136333 22879 46526819
Mood swings 12.02 10.08 18 136346 16234 46533464
Reocclusion 11.99 10.08 3 136361 4 46549694
Urine albumin/creatinine ratio increased 11.98 10.08 7 136357 164 46549534
Multiple organ dysfunction syndrome 11.97 10.08 215 136149 51495 46498203
Burn oesophageal 11.94 10.08 7 136357 165 46549533
Seizure 11.93 10.08 271 136093 122783 46426915
Drug eruption 11.91 10.08 28 136336 21301 46528397
Orthopnoea 11.85 10.08 41 136323 5839 46543859
Therapy non-responder 11.83 10.08 71 136293 41081 46508617
Vascular purpura 11.82 10.08 17 136347 1329 46548369
Septic shock 11.81 10.08 110 136254 57783 46491915
Embolic stroke 11.76 10.08 30 136334 3609 46546089
Splenic rupture 11.73 10.08 16 136348 1191 46548507
Ligament pain 11.72 10.08 7 136357 171 46549527
Cardiovascular symptom 11.70 10.08 5 136359 58 46549640
Eosinophilia 11.66 10.08 96 136268 19121 46530577
Thalamus haemorrhage 11.65 10.08 11 136353 546 46549152
Nikolsky's sign 11.63 10.08 6 136358 109 46549589
Inflammation 11.61 10.08 89 136275 48692 46501006
Cardiac arrest 11.60 10.08 346 136018 90053 46459645
Gangrene 11.51 10.08 35 136329 4660 46545038
Eructation 11.49 10.08 47 136317 7248 46542450
Sweat gland tumour 11.44 10.08 6 136358 113 46549585
Impaired work ability 11.43 10.08 12 136352 12624 46537074
Iliac vein occlusion 11.37 10.08 4 136360 26 46549672
Nuchal rigidity 11.34 10.08 11 136353 565 46549133
Oral contusion 11.33 10.08 5 136359 63 46549635
Platelet disorder 11.26 10.08 18 136346 1545 46548153
Multiple sclerosis 11.26 10.08 36 136328 24755 46524943
Phlebitis deep 11.24 10.08 3 136361 6 46549692
Anaphylactic reaction 11.23 10.08 100 136264 53012 46496686
Product complaint 11.20 10.08 67 136297 12034 46537664
Documented hypersensitivity to administered product 11.19 10.08 11 136353 574 46549124
Vascular pseudoaneurysm ruptured 11.12 10.08 5 136359 66 46549632
Infusion site pain 11.08 10.08 8 136356 10099 46539599
Subacute cutaneous lupus erythematosus 11.08 10.08 20 136344 1895 46547803
Leukopenia 11.06 10.08 137 136227 68206 46481492
Inappropriate schedule of product administration 11.03 10.08 129 136235 64884 46484814
Unresponsive to stimuli 11.02 10.08 143 136221 32031 46517667
Spontaneous haematoma 10.97 10.08 12 136352 710 46548988
Polyserositis 10.96 10.08 8 136356 276 46549422
Renal injury 10.95 10.08 56 136308 9485 46540213
Seroma 10.93 10.08 21 136343 2086 46547612
Basal ganglia haemorrhage 10.93 10.08 11 136353 591 46549107
Ventricular dysfunction 10.92 10.08 25 136339 2807 46546891
Hyperlipidaemia 10.92 10.08 92 136272 18447 46531251
Sinus rhythm 10.88 10.08 11 136353 594 46549104
Ventricular hypertrophy 10.86 10.08 30 136334 3784 46545914
Photophobia 10.86 10.08 16 136348 14528 46535170
Hyporesponsive to stimuli 10.83 10.08 13 136351 851 46548847
Wound haemorrhage 10.79 10.08 21 136343 2106 46547592
Gastroenteritis viral 10.76 10.08 23 136341 18096 46531602
Anhedonia 10.73 10.08 59 136305 10276 46539422
Hydrocephalus 10.71 10.08 35 136329 4842 46544856
Metastases to liver 10.71 10.08 26 136338 19559 46530139
Fat embolism 10.69 10.08 7 136357 202 46549496
Embolism arterial 10.68 10.08 15 136349 1148 46548550
Device difficult to use 10.67 10.08 5 136359 7999 46541699
Aneurysm repair 10.66 10.08 4 136360 32 46549666
Angiopathy 10.66 10.08 32 136332 4231 46545467
Eyelid haematoma 10.64 10.08 3 136361 8 46549690
Vascular access site haemorrhage 10.64 10.08 3 136361 8 46549690
Uveitis 10.62 10.08 6 136358 8635 46541063
Foetal growth restriction 10.62 10.08 3 136361 6564 46543134
Pain in jaw 10.61 10.08 67 136297 38305 46511393
Muscle hypertrophy 10.61 10.08 5 136359 74 46549624
Helicobacter gastritis 10.58 10.08 17 136347 1465 46548233
Duodenitis 10.54 10.08 27 136337 3256 46546442
Sinus node dysfunction 10.54 10.08 32 136332 4257 46545441
Mitral valve calcification 10.53 10.08 14 136350 1017 46548681
Prosopagnosia 10.45 10.08 4 136360 34 46549664
Essential hypertension 10.44 10.08 32 136332 4278 46545420
Nasal congestion 10.44 10.08 90 136274 48023 46501675
Rectal perforation 10.41 10.08 9 136355 398 46549300
Chest wall tumour 10.35 10.08 4 136360 35 46549663
Foot amputation 10.34 10.08 8 136356 302 46549396
Bursitis 10.34 10.08 27 136337 19815 46529883
Gastrointestinal ulcer haemorrhage 10.31 10.08 11 136353 633 46549065
Intracranial mass 10.30 10.08 15 136349 1186 46548512
Coeliac disease 10.30 10.08 4 136360 7157 46542541
Lip infection 10.26 10.08 5 136359 80 46549618
Traumatic haemorrhage 10.26 10.08 9 136355 406 46549292
Implantable defibrillator insertion 10.24 10.08 9 136355 407 46549291
Hypoglycaemic coma 10.24 10.08 23 136341 2551 46547147
Urticaria 10.23 10.08 264 136100 117628 46432070
Meningorrhagia 10.18 10.08 6 136358 143 46549555
Encephalopathy 10.16 10.08 57 136307 33532 46516166
Intestinal perforation 10.16 10.08 10 136354 10841 46538857
Colitis ulcerative 10.13 10.08 23 136341 17709 46531989
Arterial insufficiency 10.10 10.08 6 136358 145 46549553

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1641.30 10.88 2741 170104 122884 29656749
Gastrointestinal haemorrhage 946.78 10.88 1713 171132 81733 29697900
Acute myocardial infarction 940.90 10.88 1334 171511 51605 29728028
Coronary artery disease 797.94 10.88 1194 171651 48518 29731115
Melaena 653.67 10.88 869 171976 31568 29748065
Coronary arterial stent insertion 609.53 10.88 350 172495 3844 29775789
Labelled drug-drug interaction medication error 528.02 10.88 458 172387 10080 29769553
Angina pectoris 483.30 10.88 716 172129 28802 29750831
Vascular stent thrombosis 472.66 10.88 243 172602 2100 29777533
Cerebrovascular accident 466.30 10.88 1292 171553 82185 29697448
Thrombosis in device 464.19 10.88 276 172569 3250 29776383
Toxicity to various agents 371.13 10.88 288 172557 176895 29602738
Chest pain 354.30 10.88 1480 171365 116147 29663486
Drug abuse 353.26 10.88 33 172812 82039 29697594
Cerebral haemorrhage 343.09 10.88 652 172193 32235 29747398
Gastric haemorrhage 334.68 10.88 339 172506 9128 29770505
Angina unstable 325.21 10.88 378 172467 11932 29767701
Haemorrhage 315.35 10.88 770 172075 45309 29734324
Upper gastrointestinal haemorrhage 310.90 10.88 499 172346 21529 29758104
Subdural haematoma 290.25 10.88 446 172399 18526 29761107
Acute coronary syndrome 272.23 10.88 363 172482 13210 29766423
Cardiac failure congestive 265.69 10.88 1077 171768 83330 29696303
Haematemesis 255.55 10.88 505 172340 25698 29753935
Febrile neutropenia 253.09 10.88 151 172694 106542 29673091
Rectal haemorrhage 249.88 10.88 594 172251 34345 29745288
Haematoma 236.44 10.88 464 172381 23489 29756144
Anaemia 236.39 10.88 2025 170820 205967 29573666
Coronary artery occlusion 227.77 10.88 301 172544 10856 29768777
Haematuria 225.78 10.88 669 172176 44165 29735468
Haematochezia 224.68 10.88 563 172282 33659 29745974
Coronary artery stenosis 215.67 10.88 264 172581 8806 29770827
Pyrexia 193.89 10.88 958 171887 293531 29486102
Completed suicide 192.88 10.88 174 172671 99318 29680315
Off label use 191.77 10.88 765 172080 248525 29531108
Coronary artery restenosis 183.38 10.88 103 172742 1080 29778553
Haemorrhage intracranial 183.31 10.88 319 172526 14713 29764920
Vascular stent stenosis 181.55 10.88 99 172746 975 29778658
Transient ischaemic attack 177.52 10.88 426 172419 24774 29754859
Stent placement 168.71 10.88 168 172677 4428 29775205
Death 151.16 10.88 1328 171517 355955 29423678
Drug interaction 149.61 10.88 1784 171061 197784 29581849
Drug ineffective 149.42 10.88 1253 171592 339134 29440499
Post procedural haemorrhage 142.68 10.88 201 172644 7709 29771924
Coronary artery thrombosis 141.85 10.88 110 172735 2054 29777579
Cerebral infarction 141.82 10.88 403 172442 25970 29753663
Foetal exposure during pregnancy 140.95 10.88 22 172823 36849 29742784
Neutropenia 139.36 10.88 337 172508 128203 29651430
Epistaxis 137.38 10.88 638 172207 52343 29727290
Vascular pseudoaneurysm 125.33 10.88 99 172746 1901 29777732
Subarachnoid haemorrhage 123.41 10.88 212 172633 9674 29769959
Blood loss anaemia 120.42 10.88 182 172663 7445 29772188
Faeces discoloured 119.65 10.88 255 172590 13691 29765942
Disease progression 117.66 10.88 174 172671 79700 29699933
Myocardial ischaemia 115.82 10.88 287 172558 17030 29762603
Dizziness 113.72 10.88 1665 171180 193244 29586389
Product use in unapproved indication 113.02 10.88 156 172689 73537 29706096
Coronary artery bypass 111.16 10.88 143 172702 5019 29774614
Retroperitoneal haematoma 108.90 10.88 101 172744 2431 29777202
Rhabdomyolysis 107.99 10.88 682 172163 62898 29716735
Haemoptysis 105.22 10.88 406 172439 30672 29748961
Pneumonia 104.45 10.88 1333 171512 332973 29446660
Ischaemic stroke 101.82 10.88 263 172582 16012 29763621
Malignant neoplasm progression 101.16 10.88 163 172682 72124 29707509
Insulin autoimmune syndrome 99.63 10.88 41 172804 197 29779436
Infusion related reaction 99.52 10.88 55 172790 40509 29739124
Peripheral arterial occlusive disease 95.70 10.88 133 172712 5035 29774598
Lower gastrointestinal haemorrhage 95.39 10.88 167 172678 7737 29771896
Plasma cell myeloma 90.46 10.88 105 172740 53357 29726276
Arterial occlusive disease 90.28 10.88 114 172731 3926 29775707
Product administration error 87.55 10.88 230 172615 14147 29765486
Syncope 86.96 10.88 809 172036 84094 29695539
Haemoglobin decreased 86.59 10.88 1023 171822 113075 29666558
Thrombotic thrombocytopenic purpura 85.18 10.88 102 172743 3323 29776310
Carotid artery stenosis 85.03 10.88 119 172726 4535 29775098
Rheumatoid arthritis 84.71 10.88 68 172777 41129 29738504
Pancytopenia 84.41 10.88 233 172612 84819 29694814
Hemiparesis 84.29 10.88 231 172614 14571 29765062
Multiple injuries 82.36 10.88 78 172767 1929 29777704
White blood cell count decreased 81.07 10.88 233 172612 83714 29695919
Cytomegalovirus infection 80.17 10.88 19 172826 23655 29755978
Intermittent claudication 78.94 10.88 80 172765 2154 29777479
Duodenal ulcer haemorrhage 75.91 10.88 113 172732 4559 29775074
Stomatitis 74.82 10.88 63 172782 37216 29742417
Diarrhoea 74.48 10.88 1420 171425 332683 29446950
Treatment failure 72.86 10.88 56 172789 34623 29745010
Haemobilia 72.30 10.88 35 172810 262 29779371
Cardiac tamponade 72.15 10.88 110 172735 4534 29775099
Fall 70.31 10.88 1455 171390 180417 29599216
Gastritis erosive 69.57 10.88 120 172725 5493 29774140
Muscle haemorrhage 68.12 10.88 95 172750 3608 29776025
Gastric ulcer 68 10.88 217 172628 14904 29764729
Cerebral haematoma 67.44 10.88 105 172740 4409 29775224
Cardiac disorder 67.12 10.88 427 172418 39466 29740167
Therapeutic product effect incomplete 66.90 10.88 58 172787 33776 29745857
Haemorrhagic stroke 66.69 10.88 124 172721 6023 29773610
Intraventricular haemorrhage 65.33 10.88 84 172761 2946 29776687
Diverticulum intestinal haemorrhagic 65.03 10.88 70 172775 2025 29777608
Drug dependence 64.81 10.88 21 172824 21274 29758359
Infection 64.70 10.88 232 172613 77842 29701791
Presyncope 62.95 10.88 220 172625 15836 29763797
Angioplasty 62.26 10.88 50 172795 984 29778649
Mallory-Weiss syndrome 61.34 10.88 56 172789 1320 29778313
Psychotic disorder 60.74 10.88 24 172821 21491 29758142
Coronary angioplasty 60.17 10.88 34 172811 361 29779272
Sepsis 59.87 10.88 548 172297 145847 29633786
Shock haemorrhagic 59.23 10.88 157 172688 9708 29769925
Subdural haemorrhage 57.86 10.88 77 172768 2795 29776838
Neuroleptic malignant syndrome 57.35 10.88 12 172833 16283 29763350
Bleeding time prolonged 56.35 10.88 39 172806 606 29779027
Serotonin syndrome 55.60 10.88 17 172828 17874 29761759
Extradural haematoma 54.20 10.88 49 172796 1140 29778493
Spinal cord haemorrhage 54.11 10.88 30 172815 306 29779327
Duodenal ulcer 53.89 10.88 152 172693 9749 29769884
Mucosal inflammation 53.64 10.88 58 172787 30436 29749197
Leukopenia 53.37 10.88 157 172688 56002 29723631
Overdose 53.13 10.88 278 172567 84059 29695574
Arteriosclerosis 52.91 10.88 160 172685 10673 29768960
Drug intolerance 52.84 10.88 114 172731 45177 29734456
Peripheral artery stenosis 52.67 10.88 42 172803 818 29778815
Retroperitoneal haemorrhage 51.97 10.88 71 172774 2644 29776989
Contraindicated product administered 51.82 10.88 217 172628 17014 29762619
Myalgia 51.05 10.88 671 172174 75996 29703637
Premature baby 49.85 10.88 17 172828 16674 29762959
Bone marrow failure 49.83 10.88 59 172786 29726 29749907
Neuropathy peripheral 49.79 10.88 223 172622 70252 29709381
Cardiogenic shock 49.67 10.88 211 172634 16650 29762983
Aphasia 49.54 10.88 233 172612 19206 29760427
Coronary artery dissection 49.53 10.88 23 172822 155 29779478
Device occlusion 49.18 10.88 109 172736 6011 29773622
Gingival bleeding 49.16 10.88 112 172733 6292 29773341
Respiratory tract haemorrhage 48.98 10.88 40 172805 807 29778826
Ventricular fibrillation 48.98 10.88 195 172650 14943 29764690
Nasopharyngitis 48.66 10.88 175 172670 58674 29720959
Post procedural haematoma 48.56 10.88 52 172793 1495 29778138
Spinal subarachnoid haemorrhage 48.22 10.88 15 172830 24 29779609
Ischaemic cardiomyopathy 48.19 10.88 110 172735 6187 29773446
Pulmonary haematoma 47.96 10.88 17 172828 49 29779584
Intra-abdominal haematoma 47.55 10.88 48 172797 1286 29778347
Product prescribing error 47.44 10.88 207 172638 16526 29763107
Suicide attempt 47.42 10.88 87 172758 36610 29743023
Arterial stenosis 47.23 10.88 46 172799 1179 29778454
Ulcer haemorrhage 46.62 10.88 64 172781 2394 29777239
Percutaneous coronary intervention 46.32 10.88 24 172821 211 29779422
Septic shock 46.31 10.88 199 172646 63408 29716225
Hemiplegia 46.23 10.88 112 172733 6549 29773084
Contusion 46.10 10.88 324 172521 30956 29748677
Pulmonary alveolar haemorrhage 46.05 10.88 111 172734 6470 29773163
Iron deficiency anaemia 45.70 10.88 135 172710 8889 29770744
Intentional product use issue 45.67 10.88 88 172757 36352 29743281
Arthralgia 45.38 10.88 533 172312 135258 29644375
Carotid artery occlusion 45.02 10.88 57 172788 1968 29777665
International normalised ratio increased 44.93 10.88 447 172398 47292 29732341
Pneumocystis jirovecii pneumonia 43.77 10.88 22 172823 17098 29762535
Arterial restenosis 43.77 10.88 17 172828 68 29779565
Cardiac failure 43.24 10.88 699 172146 82719 29696914
Procedural haemorrhage 43.03 10.88 60 172785 2278 29777355
Electrocardiogram ST segment elevation 42.54 10.88 85 172760 4357 29775276
Fat embolism 42.50 10.88 22 172823 193 29779440
Troponin increased 42.49 10.88 130 172715 8727 29770906
Sinusitis 42.25 10.88 80 172765 33265 29746368
Suicidal ideation 42.04 10.88 91 172754 36023 29743610
Product use issue 42.03 10.88 131 172714 45885 29733748
Platelet function test abnormal 41.92 10.88 18 172827 98 29779535
Dyspnoea 41.71 10.88 2335 170510 330960 29448673
Coronary artery perforation 41.64 10.88 15 172830 46 29779587
Neutrophil count decreased 41.57 10.88 117 172728 42337 29737296
Intentional product misuse 41.49 10.88 86 172759 34581 29745052
Gastritis haemorrhagic 41.05 10.88 42 172803 1144 29778489
Immune reconstitution inflammatory syndrome 40.94 10.88 3 172842 9098 29770535
Haemorrhagic ascites 40.77 10.88 18 172827 106 29779527
Hypoglycaemia 40.34 10.88 461 172384 50520 29729113
Psoriasis 40.26 10.88 119 172726 42387 29737246
Weight increased 40.19 10.88 260 172585 74653 29704980
Gastric ulcer haemorrhage 39.75 10.88 92 172753 5222 29774411
Conjunctival haemorrhage 39.22 10.88 62 172783 2638 29776995
Drug withdrawal syndrome 39.10 10.88 34 172811 19775 29759858
Exposure during pregnancy 39.08 10.88 4 172841 9257 29770376
Aggression 38.95 10.88 98 172747 36809 29742824
Angiocardiogram 38.88 10.88 20 172825 173 29779460
Hyphaema 38.80 10.88 26 172819 382 29779251
Product dose omission issue 38.73 10.88 340 172505 91291 29688342
Pericardial haemorrhage 38.30 10.88 64 172781 2854 29776779
Haemorrhagic transformation stroke 38.26 10.88 41 172804 1180 29778453
Vascular graft occlusion 38.24 10.88 30 172815 570 29779063
Respiratory failure 38.02 10.88 384 172461 100258 29679375
Acute myeloid leukaemia 37.91 10.88 29 172816 17977 29761656
Haemothorax 37.76 10.88 71 172774 3478 29776155
Blood creatine phosphokinase MB increased 37.21 10.88 51 172794 1905 29777728
Poisoning 36.87 10.88 10 172835 11372 29768261
Injury 36.78 10.88 233 172612 21498 29758135
Ecchymosis 36.35 10.88 101 172744 6421 29773212
Posterior reversible encephalopathy syndrome 36.13 10.88 4 172841 8703 29770930
Occult blood positive 36.07 10.88 72 172773 3688 29775945
Spinal epidural haematoma 35.92 10.88 19 172826 175 29779458
Bronchopulmonary aspergillosis 35.85 10.88 13 172832 12271 29767362
Microcytic anaemia 35.85 10.88 53 172792 2125 29777508
Vascular stent occlusion 35.72 10.88 17 172828 122 29779511
Platelet count decreased 35.66 10.88 416 172429 105713 29673920
Vascular graft 35.64 10.88 43 172802 1412 29778221
Respiratory arrest 35.50 10.88 72 172773 29186 29750447
Dermatitis exfoliative 35.36 10.88 109 172736 7347 29772286
Joint swelling 35.32 10.88 145 172700 46801 29732832
Intentional overdose 35.18 10.88 122 172723 41359 29738274
Aspergillus infection 34.97 10.88 8 172837 10206 29769427
Small intestinal haemorrhage 34.86 10.88 51 172794 2025 29777608
Synovitis 34.85 10.88 7 172838 9776 29769857
Normochromic normocytic anaemia 34.52 10.88 73 172772 3897 29775736
Fatigue 34.40 10.88 1507 171338 319166 29460467
Peripheral vascular disorder 34.36 10.88 86 172759 5133 29774500
Pulmonary embolism 33.87 10.88 288 172557 77847 29701786
Intentional self-injury 33.68 10.88 18 172827 13514 29766119
Neurotoxicity 33.61 10.88 17 172828 13165 29766468
Musculoskeletal stiffness 33.58 10.88 101 172744 35780 29743853
Neoplasm progression 33.14 10.88 33 172812 17990 29761643
Acquired haemophilia 33.09 10.88 31 172814 756 29778877
Mediastinal haematoma 32.69 10.88 15 172830 98 29779535
Dystonia 32.55 10.88 8 172837 9719 29769914
Bradycardia 32.44 10.88 545 172300 64981 29714652
Kounis syndrome 32.40 10.88 44 172801 1629 29778004
Nausea 32.16 10.88 1394 171451 295563 29484070
Hospitalisation 32.04 10.88 139 172706 44180 29735453
Haemorrhage subcutaneous 31.98 10.88 51 172794 2186 29777447
Cardiac failure chronic 31.90 10.88 90 172755 5773 29773860
Drug hypersensitivity 31.78 10.88 248 172597 68271 29711362
Mesenteric artery thrombosis 31.73 10.88 24 172821 431 29779202
Vitreous haemorrhage 31.41 10.88 49 172796 2061 29777572
Encephalopathy 31.34 10.88 89 172756 32116 29747517
Haemorrhagic arteriovenous malformation 31.19 10.88 22 172823 353 29779280
Psoriatic arthropathy 31.17 10.88 27 172818 15734 29763899
Hepatic encephalopathy 30.99 10.88 22 172823 14170 29765463
Agitation 30.90 10.88 184 172661 53889 29725744
Puncture site haemorrhage 30.63 10.88 21 172824 321 29779312
Shone complex 30.55 10.88 13 172832 69 29779564
Insomnia 30.52 10.88 368 172477 92968 29686665
Vomiting 30.40 10.88 1002 171843 218816 29560817
Device related infection 30.32 10.88 32 172813 16983 29762650
Ischaemia 30.29 10.88 75 172770 4446 29775187
Asthma 30.27 10.88 107 172738 36067 29743566
Neutropenic sepsis 30.17 10.88 14 172831 11395 29768238
Spontaneous haemorrhage 29.96 10.88 17 172828 182 29779451
Wound haemorrhage 29.95 10.88 44 172801 1754 29777879
Catheter site haematoma 29.65 10.88 16 172829 154 29779479
Hepatitis C 29.46 10.88 20 172825 13185 29766448
Therapeutic product effect decreased 29.30 10.88 79 172766 28997 29750636
Peripheral ischaemia 29.14 10.88 82 172763 5252 29774381
Gastritis 29.05 10.88 208 172637 19990 29759643
Lower respiratory tract infection 28.91 10.88 70 172775 26644 29752989
Colitis 28.67 10.88 87 172758 30733 29748900
Head injury 28.50 10.88 182 172663 16838 29762795
Arteriosclerosis coronary artery 28.50 10.88 134 172711 11042 29768591
Atrial thrombosis 28.44 10.88 44 172801 1837 29777796
Tachycardia 28.40 10.88 280 172565 73459 29706174
Mouth haemorrhage 28.26 10.88 78 172767 4939 29774694
Myocardial rupture 28.22 10.88 16 172829 171 29779462
Haemorrhage urinary tract 28.03 10.88 41 172804 1628 29778005
Rash 27.64 10.88 870 171975 191019 29588614
Schizophrenia 27.40 10.88 9 172836 9039 29770594
Cardiac ventricular thrombosis 27.18 10.88 28 172817 769 29778864
Injection site pain 27.17 10.88 87 172758 30223 29749410
Hypotension 27.15 10.88 1416 171429 199149 29580484
Somnolence 27.08 10.88 394 172451 96369 29683264
Duodenitis 27.05 10.88 67 172778 3973 29775660
Pallor 27.01 10.88 211 172634 20838 29758795
Thrombocytopenic purpura 26.63 10.88 32 172813 1046 29778587
Headache 26.63 10.88 825 172020 181481 29598152
Cerebral hyperperfusion syndrome 26.46 10.88 12 172833 76 29779557
Cardiac aneurysm 26.31 10.88 25 172820 621 29779012
Deep vein thrombosis 26.21 10.88 223 172622 60278 29719355
Laryngeal haemorrhage 26.16 10.88 9 172836 23 29779610
Herpes zoster 26.12 10.88 87 172758 29856 29749777
Coagulation time abnormal 26.09 10.88 15 172830 165 29779468
Aortic stenosis 25.92 10.88 66 172779 3982 29775651
Petechiae 25.91 10.88 113 172732 9018 29770615
Cerebellar haemorrhage 25.80 10.88 36 172809 1368 29778265
Sedation 25.74 10.88 34 172811 16339 29763294
Coronary artery reocclusion 25.41 10.88 13 172832 111 29779522
Skin flap necrosis 25.27 10.88 8 172837 14 29779619
Irritability 25.26 10.88 60 172785 22990 29756643
Haematotoxicity 25.19 10.88 3 172842 6167 29773466
Influenza 25.15 10.88 147 172698 43251 29736382
Aorta hypoplasia 24.88 10.88 12 172833 89 29779544
Osteonecrosis 24.87 10.88 34 172811 16101 29763532
Pituitary haemorrhage 24.84 10.88 15 172830 182 29779451
Hyperbilirubinaemia 24.83 10.88 37 172808 16905 29762728
Transplant rejection 24.81 10.88 11 172834 9195 29770438
Infarction 24.79 10.88 50 172795 2580 29777053
Lymphocyte count decreased 24.77 10.88 45 172800 19010 29760623
Cellulitis 24.76 10.88 163 172682 46621 29733012
Ventricular tachycardia 24.70 10.88 228 172617 23634 29755999
Depression 24.69 10.88 370 172475 90067 29689566
Coronary revascularisation 24.59 10.88 8 172837 16 29779617
Lacunar infarction 24.02 10.88 55 172790 3100 29776533
Heparin-induced thrombocytopenia 23.97 10.88 77 172768 5306 29774327
Sudden cardiac death 23.84 10.88 61 172784 3691 29775942
Vessel puncture site haematoma 23.82 10.88 10 172835 51 29779582
Intracardiac thrombus 23.63 10.88 47 172798 2401 29777232
Epstein-Barr virus infection 23.47 10.88 5 172840 6701 29772932
Substance abuse 23.15 10.88 6 172839 7034 29772599
Peripheral swelling 23.06 10.88 233 172612 60841 29718792
Venoocclusive liver disease 23.00 10.88 5 172840 6608 29773025
Alopecia 22.90 10.88 48 172797 19227 29760406
Oropharyngeal pain 22.71 10.88 86 172759 28410 29751223
Traumatic haemothorax 22.58 10.88 15 172830 217 29779416
Parinaud syndrome 22.55 10.88 6 172839 3 29779630
Subacute hepatic failure 22.54 10.88 11 172834 84 29779549
Peptic ulcer haemorrhage 22.49 10.88 20 172825 455 29779178
Gastrointestinal polyp haemorrhage 22.35 10.88 16 172829 263 29779370
Gastrointestinal vascular malformation haemorrhagic 22.08 10.88 21 172824 522 29779111
Cytopenia 22.04 10.88 10 172835 8246 29771387
Ischaemic cerebral infarction 22.01 10.88 27 172818 902 29778731
Skin haemorrhage 21.93 10.88 56 172789 3384 29776249
Nipple exudate bloody 21.92 10.88 6 172839 4 29779629
Haemorrhagic infarction 21.80 10.88 18 172827 369 29779264
Diffuse large B-cell lymphoma 21.72 10.88 9 172836 7832 29771801
Alanine aminotransferase increased 21.63 10.88 300 172545 73976 29705657
Mania 21.60 10.88 13 172832 9141 29770492
Acute right ventricular failure 21.59 10.88 11 172834 93 29779540
Purpura 21.52 10.88 114 172731 9853 29769780
Supravalvular aortic stenosis 21.42 10.88 9 172836 46 29779587
Pharyngeal haematoma 21.42 10.88 8 172837 28 29779605
Ear haemorrhage 21.35 10.88 26 172819 862 29778771
Mesenteric arterial occlusion 21.20 10.88 7 172838 15 29779618
Electrocardiogram ST segment depression 21.20 10.88 44 172801 2318 29777315
Thrombosis 21.16 10.88 352 172493 41879 29737754
Chills 21.13 10.88 292 172553 72046 29707587
Subcutaneous haematoma 21.13 10.88 27 172818 941 29778692
Thrombotic cerebral infarction 21.08 10.88 16 172829 289 29779344
Incision site haemorrhage 20.87 10.88 20 172825 502 29779131
Orthostatic hypotension 20.87 10.88 221 172624 23758 29755875
Pain 20.85 10.88 800 172045 171841 29607792
Product shape issue 20.80 10.88 5 172840 0 29779633
Wrong dosage formulation 20.80 10.88 5 172840 0 29779633
Blood bilirubin increased 20.75 10.88 125 172720 36511 29743122
Oxygen saturation decreased 20.71 10.88 156 172689 43284 29736349
Respiratory tract infection 20.71 10.88 36 172809 15470 29764163
Labelled drug-disease interaction medication error 20.64 10.88 11 172834 103 29779530
Prostatic adenoma 20.63 10.88 13 172832 171 29779462
Fungal infection 20.62 10.88 29 172816 13571 29766062
Cytomegalovirus viraemia 20.61 10.88 4 172841 5725 29773908
Upper respiratory tract infection 20.58 10.88 85 172760 27391 29752242
Implant site haematoma 20.53 10.88 10 172835 76 29779557
Adverse drug reaction 20.35 10.88 67 172778 23078 29756555
Vascular occlusion 20.35 10.88 27 172818 977 29778656
Hallucination, auditory 20.31 10.88 16 172829 9773 29769860
Candida infection 20.22 10.88 36 172809 15326 29764307
Embolic stroke 20.10 10.88 56 172789 3566 29776067
Colonic haematoma 20.03 10.88 8 172837 35 29779598
Atheroembolism 19.99 10.88 14 172831 222 29779411
Drug ineffective for unapproved indication 19.91 10.88 20 172825 10860 29768773
Pneumonitis 19.90 10.88 86 172759 27368 29752265
C-reactive protein increased 19.84 10.88 158 172687 43315 29736318
Lymphadenopathy 19.80 10.88 73 172772 24303 29755330
Generalised tonic-clonic seizure 19.79 10.88 53 172792 19498 29760135
Gastrointestinal tract mucosal pigmentation 19.67 10.88 14 172831 228 29779405
Swollen tongue 19.64 10.88 137 172708 13055 29766578
Aspartate aminotransferase increased 19.61 10.88 253 172592 63169 29716464
Reperfusion injury 19.59 10.88 10 172835 85 29779548
Product substitution error 19.54 10.88 7 172838 21 29779612
Monoparesis 19.50 10.88 31 172814 1325 29778308
Poisoning deliberate 19.48 10.88 5 172840 5899 29773734
Traumatic haematoma 19.46 10.88 22 172823 673 29778960
Circulatory collapse 19.36 10.88 190 172655 20024 29759609
Asthenia 19.23 10.88 1504 171341 219786 29559847
Haemophagocytic lymphohistiocytosis 19.09 10.88 17 172828 9774 29769859
Haemodynamic instability 18.92 10.88 94 172751 7921 29771712
Mitral valve hypoplasia 18.87 10.88 8 172837 42 29779591
Mitral valve incompetence 18.86 10.88 136 172709 13098 29766535
Gallbladder neoplasm 18.85 10.88 7 172838 24 29779609
Post procedural complication 18.78 10.88 124 172721 11602 29768031
Spontaneous haematoma 18.76 10.88 19 172826 511 29779122
Arterial intramural haematoma 18.72 10.88 8 172837 43 29779590
Wound 18.58 10.88 129 172716 12273 29767360
Low birth weight baby 18.47 10.88 6 172839 6070 29773563
Hepatitis B 18.45 10.88 6 172839 6066 29773567
Muscle rupture 18.44 10.88 39 172806 2082 29777551
Oesophagitis 18.42 10.88 119 172726 11052 29768581
Arteriosclerotic gangrene 18.30 10.88 9 172836 70 29779563
Ileus 18.26 10.88 39 172806 15516 29764117
Benign gastrointestinal neoplasm 18.25 10.88 11 172834 133 29779500
Blood pressure decreased 18.24 10.88 377 172468 46698 29732935
Constipation 18.20 10.88 504 172341 112402 29667231
Subarachnoid haematoma 18.19 10.88 9 172836 71 29779562
Ascites 18.09 10.88 127 172718 35794 29743839
Peripheral artery occlusion 18.03 10.88 31 172814 1415 29778218
Splenic haemorrhage 17.88 10.88 16 172829 367 29779266
Chest discomfort 17.87 10.88 365 172480 45115 29734518
Laboratory test abnormal 17.87 10.88 47 172798 17395 29762238
Eosinophilia 17.79 10.88 201 172644 21959 29757674
Mood swings 17.76 10.88 11 172834 7615 29772018
Gastrointestinal angiodysplasia 17.66 10.88 18 172827 488 29779145
Acute pulmonary oedema 17.65 10.88 88 172757 7427 29772206
Albumin urine present 17.63 10.88 16 172829 374 29779259
Myocardial necrosis marker increased 17.57 10.88 32 172813 1529 29778104
Blood cholesterol 17.55 10.88 10 172835 108 29779525
Brain stem haemorrhage 17.53 10.88 23 172822 823 29778810
Insulin C-peptide increased 17.47 10.88 8 172837 52 29779581
Metallosis of globe 17.37 10.88 5 172840 5 29779628
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits 17.37 10.88 5 172840 5 29779628
CYP2C19 polymorphism 17.37 10.88 5 172840 5 29779628
Traumatic haemorrhage 17.35 10.88 20 172825 625 29779008
Intestinal obstruction 17.32 10.88 55 172790 19157 29760476
Intestinal haemorrhage 17.28 10.88 49 172796 3152 29776481
Tardive dyskinesia 17.24 10.88 4 172841 5053 29774580
Arterial disorder 17.21 10.88 27 172818 1141 29778492
Coronary artery embolism 17.18 10.88 11 172834 149 29779484
Catheterisation cardiac 17.10 10.88 39 172806 2192 29777441
Lactic acidosis 17.08 10.88 264 172581 30949 29748684
Withdrawal syndrome 17.04 10.88 24 172821 11226 29768407
COVID-19 16.96 10.88 50 172795 17828 29761805
Abnormal behaviour 16.95 10.88 83 172762 25540 29754093
Dyspnoea exertional 16.91 10.88 293 172552 35137 29744496
Encephalitis 16.86 10.88 8 172837 6428 29773205
Colitis microscopic 16.80 10.88 33 172812 1670 29777963
Supine hypertension 16.70 10.88 13 172832 244 29779389
Clostridium difficile infection 16.58 10.88 42 172803 15741 29763892
Seizure 16.54 10.88 437 172408 98038 29681595
Large intestine perforation 16.52 10.88 12 172833 7639 29771994
Platelet aggregation abnormal 16.51 10.88 6 172839 19 29779614
Myelosuppression 16.45 10.88 11 172834 7311 29772322
Toxic epidermal necrolysis 16.43 10.88 51 172794 17889 29761744
Oral candidiasis 16.39 10.88 24 172821 11047 29768586
Condition aggravated 16.38 10.88 640 172205 137226 29642407
Troponin I increased 16.28 10.88 34 172811 1799 29777834
Bladder tamponade 16.27 10.88 16 172829 415 29779218
C-reactive protein abnormal 16.18 10.88 6 172839 5587 29774046
Staphylococcal infection 16.14 10.88 105 172740 30119 29749514
Hepatocellular carcinoma 16.11 10.88 19 172826 9591 29770042
Inappropriate schedule of product administration 16.07 10.88 149 172696 39579 29740054
Drug screen positive 16.02 10.88 3 172842 4404 29775229
Akathisia 15.99 10.88 7 172838 5897 29773736
Chronic kidney disease 15.98 10.88 307 172538 37531 29742102
Injection site erythema 15.98 10.88 35 172810 13799 29765834
Osteoporosis 15.90 10.88 23 172822 10640 29768993
Pneumonia fungal 15.90 10.88 6 172839 5527 29774106
Retinal artery occlusion 15.86 10.88 32 172813 1652 29777981
Cerebral artery stenosis 15.83 10.88 14 172831 316 29779317
Wound haematoma 15.77 10.88 8 172837 67 29779566
Polyarthritis 15.70 10.88 48 172797 3221 29776412
Intracranial haematoma 15.67 10.88 15 172830 376 29779257
Multiple sclerosis relapse 15.65 10.88 24 172821 10838 29768795
Arthropathy 15.60 10.88 64 172781 20663 29758970
Creatinine renal clearance decreased 15.53 10.88 49 172796 3344 29776289
Psychological trauma 15.41 10.88 11 172834 180 29779453
Maternal drugs affecting foetus 15.34 10.88 3 172842 4270 29775363
Anxiety 15.30 10.88 398 172447 89473 29690160
Intra-abdominal haemorrhage 15.29 10.88 36 172809 2066 29777567
Ill-defined disorder 15.26 10.88 23 172822 10461 29769172
Spinal cord haematoma 15.20 10.88 9 172836 105 29779528
Product odour abnormal 15.13 10.88 18 172827 582 29779051
Urinary bladder haemorrhage 15.10 10.88 31 172814 1620 29778013
Arterial injury 15.09 10.88 13 172832 283 29779350
Hepatic steatosis 15.05 10.88 40 172805 14753 29764880
Blood creatine phosphokinase increased 15.02 10.88 345 172500 43503 29736130
Concomitant disease progression 15.02 10.88 40 172805 2480 29777153
Prescribed underdose 14.91 10.88 86 172759 7673 29771960
Peritonitis 14.86 10.88 68 172777 21307 29758326
Nephropathy toxic 14.86 10.88 24 172821 10615 29769018
Post-traumatic amnestic disorder 14.85 10.88 7 172838 49 29779584
Consciousness fluctuating 14.78 10.88 23 172822 965 29778668
Thyroid haemorrhage 14.75 10.88 5 172840 12 29779621
Haemarthrosis 14.73 10.88 44 172801 2915 29776718
Upper motor neurone lesion 14.71 10.88 9 172836 112 29779521
Loss of personal independence in daily activities 14.68 10.88 69 172776 21466 29758167
Ankylosing spondylitis 14.65 10.88 4 172841 4530 29775103
Intracranial aneurysm 14.65 10.88 25 172820 1134 29778499
Haemorrhagic cyst 14.62 10.88 7 172838 51 29779582
Multiple organ dysfunction syndrome 14.60 10.88 268 172577 63219 29716414
Vessel puncture site haemorrhage 14.57 10.88 8 172837 80 29779553
Palmar-plantar erythrodysaesthesia syndrome 14.53 10.88 41 172804 14829 29764804
Hemiataxia 14.39 10.88 6 172839 30 29779603
Hepatic cirrhosis 14.28 10.88 46 172799 15953 29763680
No adverse event 14.25 10.88 52 172793 17367 29762266
Splenic rupture 14.24 10.88 29 172816 1507 29778126
Brain contusion 14.21 10.88 20 172825 766 29778867
Congenital heart valve disorder 14.17 10.88 7 172838 55 29779578
Arterial stent insertion 14.15 10.88 8 172837 85 29779548
Electrocardiogram Q wave abnormal 13.92 10.88 9 172836 124 29779509
Progressive multifocal leukoencephalopathy 13.88 10.88 19 172826 8994 29770639
Rectal ulcer 13.87 10.88 21 172824 860 29778773
Acute respiratory distress syndrome 13.87 10.88 79 172766 23393 29756240
Intrapericardial thrombosis 13.86 10.88 7 172838 58 29779575
Angioedema 13.86 10.88 277 172568 34107 29745526
Diverticulum 13.85 10.88 76 172769 6657 29772976
Eye haemorrhage 13.85 10.88 50 172795 3657 29775976
Small intestinal obstruction 13.84 10.88 37 172808 13622 29766011
BK virus infection 13.83 10.88 4 172841 4360 29775273
Abdominal wall haematoma 13.82 10.88 30 172815 1631 29778002
Carotid artery dissection 13.80 10.88 9 172836 126 29779507
Post procedural myocardial infarction 13.78 10.88 6 172839 34 29779599
Tumour lysis syndrome 13.76 10.88 34 172811 12851 29766782
Haemorrhagic erosive gastritis 13.68 10.88 9 172836 128 29779505
Haemodilution 13.64 10.88 6 172839 35 29779598
Cutaneous lupus erythematosus 13.51 10.88 17 172828 583 29779050
Myelodysplastic syndrome 13.50 10.88 59 172786 18719 29760914
Bundle branch block right 13.50 10.88 78 172767 6964 29772669
Alcohol abuse 13.50 10.88 7 172838 5346 29774287
Primary hypoparathyroidism 13.50 10.88 6 172839 36 29779597
Haemorrhage coronary artery 13.49 10.88 5 172840 17 29779616
Transcatheter aortic valve implantation 13.43 10.88 4 172841 5 29779628
Cholestatic liver injury 13.41 10.88 29 172816 1572 29778061
Vertigo 13.37 10.88 194 172651 22441 29757192
Respiratory depression 13.37 10.88 29 172816 11474 29768159
Subacute cutaneous lupus erythematosus 13.36 10.88 18 172827 661 29778972
Ventricular hypokinesia 13.34 10.88 54 172791 4169 29775464
Viral infection 13.32 10.88 44 172801 15141 29764492
Maternal exposure during pregnancy 13.32 10.88 3 172842 3868 29775765
Factor V inhibition 13.30 10.88 10 172835 178 29779455
Platelet aggregation decreased 13.28 10.88 5 172840 18 29779615
Arterial bypass operation 13.23 10.88 6 172839 38 29779595
Blood pressure fluctuation 13.20 10.88 54 172791 17449 29762184
N-terminal prohormone brain natriuretic peptide increased 13.18 10.88 26 172819 1320 29778313
Hypocoagulable state 13.17 10.88 21 172824 900 29778733
Arteriovenous malformation 13.14 10.88 17 172828 600 29779033
Bacteraemia 13.03 10.88 46 172799 15514 29764119
Peritonitis bacterial 12.96 10.88 29 172816 11349 29768284
Aneurysm 12.89 10.88 30 172815 1709 29777924
Internal haemorrhage 12.76 10.88 55 172790 4367 29775266
Immunosuppression 12.71 10.88 7 172838 5168 29774465
Panic attack 12.68 10.88 19 172826 8662 29770971
Bradyarrhythmia 12.68 10.88 32 172813 1920 29777713
Post procedural cellulitis 12.64 10.88 4 172841 7 29779626
Haematocoele 12.64 10.88 4 172841 7 29779626
Escherichia infection 12.63 10.88 11 172834 6394 29773239
Gastrointestinal angiectasia 12.60 10.88 11 172834 244 29779389
High density lipoprotein decreased 12.59 10.88 44 172801 3166 29776467
Non-cardiac chest pain 12.58 10.88 52 172793 4052 29775581
Myoglobinaemia 12.58 10.88 8 172837 107 29779526
Quadriparesis 12.57 10.88 22 172823 1019 29778614
Herpes simplex 12.56 10.88 5 172840 4459 29775174
Thalamus haemorrhage 12.56 10.88 21 172824 937 29778696
Upper airway obstruction 12.56 10.88 16 172829 556 29779077
Febrile bone marrow aplasia 12.54 10.88 17 172828 8080 29771553
Amaurosis fugax 12.53 10.88 16 172829 557 29779076
Strangury 12.52 10.88 8 172837 108 29779525
Oesophageal mucosal dissection 12.48 10.88 3 172842 0 29779633
Peripheral artery stent insertion 12.48 10.88 3 172842 0 29779633
Hypertrophy of tongue papillae 12.48 10.88 3 172842 0 29779633
Post stroke seizure 12.48 10.88 3 172842 0 29779633
Peripheral revascularisation 12.48 10.88 3 172842 0 29779633
Cough 12.48 10.88 595 172250 125047 29654586
Tuberculosis 12.47 10.88 17 172828 8060 29771573
Cystitis haemorrhagic 12.46 10.88 6 172839 4781 29774852
Hepatotoxicity 12.45 10.88 58 172787 18087 29761546
Metastases to liver 12.44 10.88 32 172813 11933 29767700
Kidney transplant rejection 12.42 10.88 15 172830 7494 29772139
Muscle injury 12.38 10.88 24 172821 1203 29778430
Body temperature decreased 12.37 10.88 23 172822 9632 29770001
Neutrophil count increased 12.37 10.88 46 172799 15277 29764356
Urinary hesitation 12.36 10.88 35 172810 2249 29777384
Weight decreased 12.31 10.88 729 172116 150192 29629441
Cardiac stress test 12.30 10.88 4 172841 8 29779625
Drug abuser 12.27 10.88 5 172840 4396 29775237
Aortic valve stenosis 12.26 10.88 29 172816 1670 29777963
Anal abscess 12.24 10.88 7 172838 5062 29774571
Aortic valve calcification 12.21 10.88 12 172833 311 29779322
Emotional distress 12.21 10.88 142 172703 15623 29764010
Lymphoma 12.20 10.88 25 172820 10096 29769537
Macular ischaemia 12.18 10.88 7 172838 77 29779556
Catatonia 12.18 10.88 5 172840 4375 29775258
Device embolisation 12.15 10.88 5 172840 24 29779609
Heart rate increased 12.14 10.88 154 172691 38567 29741066
Neonatal respiratory distress syndrome 12.13 10.88 4 172841 4008 29775625
Erosive oesophagitis 12.08 10.88 26 172819 1405 29778228
Compartment syndrome 12.04 10.88 37 172808 2490 29777143
Thoracic haemorrhage 12.03 10.88 10 172835 207 29779426
Dyspnoea paroxysmal nocturnal 12.01 10.88 23 172822 1142 29778491
Stent malfunction 11.99 10.88 5 172840 25 29779608
Hiatus hernia 11.98 10.88 76 172769 7014 29772619
Peripheral artery restenosis 11.98 10.88 4 172841 9 29779624
Laryngeal haematoma 11.97 10.88 8 172837 117 29779516
Knee arthroplasty 11.94 10.88 9 172836 5621 29774012
Blue toe syndrome 11.93 10.88 9 172836 161 29779472
Anhedonia 11.92 10.88 86 172759 8283 29771350
Prostate cancer 11.91 10.88 85 172760 23872 29755761
Ejection fraction decreased 11.89 10.88 137 172708 15038 29764595
Gastrointestinal ulcer 11.89 10.88 29 172816 1703 29777930
Urinary bladder polyp 11.87 10.88 7 172838 81 29779552
Serum ferritin abnormal 11.87 10.88 10 172835 211 29779422
Crying 11.85 10.88 9 172836 5600 29774033
Cardioactive drug level increased 11.85 10.88 28 172817 1611 29778022
Nerve degeneration 11.84 10.88 9 172836 163 29779470
Myocarditis 11.83 10.88 25 172820 9986 29769647
Hypovolaemic shock 11.82 10.88 71 172774 6429 29773204
Vestibular neuronitis 11.80 10.88 7 172838 82 29779551
Lipodystrophy acquired 11.77 10.88 3 172842 3557 29776076
Blood pressure orthostatic abnormal 11.73 10.88 7 172838 83 29779550
Coronary ostial stenosis 11.73 10.88 7 172838 83 29779550
Decreased appetite 11.71 10.88 727 172118 149183 29630450
Carotid artery stent insertion 11.69 10.88 4 172841 10 29779623
Thrombotic stroke 11.68 10.88 11 172834 270 29779363
Wheezing 11.68 10.88 118 172727 30820 29748813
Therapeutic drug monitoring analysis not performed 11.65 10.88 13 172832 392 29779241
Hepatic function abnormal 11.65 10.88 171 172674 41774 29737859
Gastrointestinal disorder 11.61 10.88 105 172740 28032 29751601
Paranoia 11.58 10.88 26 172819 10162 29769471
Urinary tract infection 11.55 10.88 330 172515 73329 29706304
Hypokalaemia 11.50 10.88 212 172633 49980 29729653
Contrast media reaction 11.49 10.88 19 172826 840 29778793
Oesophagitis haemorrhagic 11.49 10.88 10 172835 221 29779412
Catheter site haemorrhage 11.48 10.88 33 172812 2139 29777494
Cerebral microhaemorrhage 11.46 10.88 6 172839 54 29779579
Anti-insulin antibody increased 11.45 10.88 7 172838 87 29779546
Atrioventricular block complete 11.44 10.88 86 172759 8391 29771242
Dysarthria 11.42 10.88 243 172602 30247 29749386
Osteonecrosis of jaw 11.36 10.88 62 172783 18556 29761077
Haemorrhagic cerebral infarction 11.35 10.88 18 172827 768 29778865
Therapeutic response decreased 11.34 10.88 88 172757 24261 29755372
Brain stem infarction 11.34 10.88 24 172821 1282 29778351
Hypoxia 11.32 10.88 201 172644 47653 29731980
Needle issue 11.28 10.88 4 172841 3828 29775805
Nocardiosis 11.26 10.88 3 172842 3452 29776181
Epiglottic oedema 11.25 10.88 9 172836 176 29779457
Arteriospasm coronary 11.25 10.88 37 172808 2581 29777052
Oesophageal ulcer 11.24 10.88 43 172802 3234 29776399
Sinus bradycardia 11.23 10.88 110 172735 11585 29768048
Cardiac stress test abnormal 11.21 10.88 12 172833 345 29779288
Chest wall haematoma 11.20 10.88 8 172837 131 29779502
Carotid artery disease 11.20 10.88 20 172825 941 29778692
Congenital aortic anomaly 11.18 10.88 7 172838 91 29779542
Osteitis deformans 11.11 10.88 5 172840 31 29779602
Traumatic intracranial haemorrhage 11.09 10.88 16 172829 627 29779006
Coagulation time prolonged 11.09 10.88 23 172822 1211 29778422
Enterococcal infection 11.07 10.88 19 172826 8205 29771428
Alcoholism 11.06 10.88 3 172842 3411 29776222
Injection site reaction 11.02 10.88 29 172816 10731 29768902
Oral herpes 10.98 10.88 6 172839 4449 29775184
Haematocrit decreased 10.97 10.88 243 172602 30456 29749177
Haemorrhagic disorder 10.95 10.88 15 172830 560 29779073
Tongue haemorrhage 10.93 10.88 14 172831 489 29779144
Agnosia 10.92 10.88 6 172839 60 29779573
Implantable defibrillator insertion 10.90 10.88 17 172828 715 29778918
Cutaneous vasculitis 10.88 10.88 40 172805 2951 29776682
Cervical cord compression 10.88 10.88 9 172836 185 29779448
Haematoma evacuation 10.88 10.88 9 172836 185 29779448

Pharmacologic Action:

SourceCodeDescription
ATC B01AC04 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
FDA PE N0000008832 Decreased Platelet Aggregation
CHEBI has role CHEBI:50249 anticoagulante
CHEBI has role CHEBI:50427 platelet aggregation inhibitors
CHEBI has role CHEBI:68563 purinergic receptor subtype p2y12 antagonist
MeSH PA D006401 Hematologic Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D058914 Purinergic Antagonists
MeSH PA D058919 Purinergic P2 Receptor Antagonists
MeSH PA D058921 Purinergic P2Y Receptor Antagonists
FDA EPC N0000182142 P2Y12 Platelet Inhibitor
FDA MoA N0000182143 P2Y12 Receptor Antagonists
FDA MoA N0000187062 Cytochrome P450 2C8 Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Cerebral embolism indication 75543006 DOID:4372
Non-Q wave myocardial infarction indication 314207007
Acute coronary syndrome indication 394659003
Acute ST segment elevation myocardial infarction indication 401303003
Myocardial Reinfarction Prevention indication
Peripheral Arterial Thromboembolism Prevention indication
Intracranial hemorrhage contraindication 1386000
Acute hemorrhage contraindication 8573003
Retinal hemorrhage contraindication 28998008
Gastrointestinal ulcer contraindication 40845000
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Acute hepatic failure contraindication 197270009
Surgical procedure contraindication 387713003
Traumatic injury contraindication 417746004
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
P2Y purinoceptor 12 GPCR ANTAGONIST Ki 6.90 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.52 DRUG MATRIX
Cytochrome P450 2B6 Enzyme Ki 6.30 WOMBAT-PK

External reference:

IDSource
4024096 VUID
N0000022101 NUI
D00769 KEGG_DRUG
120202-66-6 SECONDARY_CAS_RN
4021078 VANDF
4024096 VANDF
C0070166 UMLSCUI
CHEBI:37941 CHEBI
CGE PDB_CHEM_ID
CHEMBL1771 ChEMBL_ID
CHEMBL1083385 ChEMBL_ID
DB00758 DRUGBANK_ID
D000077144 MESH_DESCRIPTOR_UI
60606 PUBCHEM_CID
7150 IUPHAR_LIGAND_ID
5908 INN_ID
A74586SNO7 UNII
236991 RXNORM
24922 MMSL
4480 MMSL
87809 MMSL
d04258 MMSL
007363 NDDF
007364 NDDF
015645 NDDF
015649 NDDF
108979001 SNOMEDCT_US
386952008 SNOMEDCT_US
412354008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 0024-1171 TABLET, FILM COATED 75 mg ORAL NDA 28 sections
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 0024-1332 TABLET, FILM COATED 300 mg ORAL NDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0093-7314 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0615-8014 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6294 TABLET 75 mg ORAL ANDA 20 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0904-6467 TABLET, FILM COATED 300 mg ORAL ANDA 27 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 13668-141 TABLET 75 mg ORAL ANDA 20 sections
PLAVIX HUMAN PRESCRIPTION DRUG LABEL 1 16590-288 TABLET, FILM COATED 75 mg ORAL NDA 12 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 16729-218 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 16729-219 TABLET, FILM COATED 300 mg ORAL ANDA 28 sections
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 21695-665 TABLET, FILM COATED 75 mg ORAL NDA 28 sections
clopidogrel Human Prescription Drug Label 1 31722-901 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
clopidogrel Human Prescription Drug Label 1 31722-902 TABLET, FILM COATED 300 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 33261-987 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel Human Prescription Drug Label 1 33342-060 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 42543-713 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 42543-714 TABLET 300 mg ORAL ANDA 27 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 43063-371 TABLET 75 mg ORAL ANDA 20 sections
clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 43353-269 TABLET, FILM COATED 75 mg ORAL ANDA 29 sections
CLOPIDOGREL HUMAN PRESCRIPTION DRUG LABEL 1 43547-484 TABLET 75 mg ORAL ANDA 22 sections
CLOPIDOGREL HUMAN PRESCRIPTION DRUG LABEL 1 43547-485 TABLET 300 mg ORAL ANDA 22 sections
Clopidogrel Bisulfate Human Prescription Drug Label 1 47335-894 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel Bisulfate Human Prescription Drug Label 1 50090-1300 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 50090-1301 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 50090-2598 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 50090-2598 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 50090-4918 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 50090-5330 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 50228-121 TABLET, FILM COATED 300 mg ORAL ANDA 26 sections
Clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 50228-124 TABLET, FILM COATED 75 mg ORAL ANDA 26 sections