clopidogrel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
platelet aggregation inhibitors 708 113665-84-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clopidogrel
  • zyllt
  • clopidogrel bisulfate
  • clopidogrel besilate
  • clopidogrel hydrochloride
  • clopidogrel hydrogen sulphate
  • clopidogrel hydrobromide
  • clopidogrel sulfate
  • clopidogrel HCl
A ticlopidine analog and platelet purinergic P2Y receptor antagonist that inhibits adenosine diphosphate-mediated PLATELET AGGREGATION. It is used to prevent THROMBOEMBOLISM in patients with ARTERIAL OCCLUSIVE DISEASES; MYOCARDIAL INFARCTION; STROKE; or ATRIAL FIBRILLATION.
  • Molecular weight: 321.82
  • Formula: C16H16ClNO2S
  • CLOGP: 4.21
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 29.54
  • ALOGS: -4.43
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.32 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.01 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 23.65 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.06 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PRKDC,STK33,TEK,TTK 32
kinase-selectivity-class AXL,BRAF,EIF2AK3,GRK2,PDK4 5
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1

Approvals:

DateAgencyCompanyOrphan
July 15, 1998 EMA
Nov. 17, 1997 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2724.69 9.81 2001 178005 103971 90344470
Gastrointestinal haemorrhage 1607.65 9.81 1374 178632 88874 90359567
Acute myocardial infarction 1445.50 9.81 887 179119 34003 90414438
Cerebrovascular accident 1180.21 9.81 1338 178668 122195 90326246
Coronary artery disease 1081.49 9.81 729 179277 32894 90415547
Anaemia 829.56 9.81 2025 177981 350777 90097664
Melaena 805.83 9.81 618 179388 34179 90414262
Drug interaction 614.57 9.81 1554 178452 274899 90173542
Labelled drug-drug interaction medication error 601.86 9.81 370 179636 14212 90434229
Synovitis 600.15 9.81 11 179995 329741 90118700
Cardiac failure congestive 589.75 9.81 847 179159 97847 90350594
Pemphigus 578.82 9.81 15 179991 326849 90121592
Systemic lupus erythematosus 573.33 9.81 37 179969 361859 90086582
Haematoma 559.03 9.81 526 179480 38522 90409919
Hand deformity 551.55 9.81 7 179999 296355 90152086
Cerebral haemorrhage 538.76 9.81 488 179518 34034 90414407
Coronary arterial stent insertion 537.31 9.81 205 179801 2635 90445806
Transient ischaemic attack 501.68 9.81 519 179487 42657 90405784
Angina pectoris 482.76 9.81 486 179520 38674 90409767
Acute kidney injury 482.09 9.81 1565 178441 318822 90129619
Upper gastrointestinal haemorrhage 471.36 9.81 380 179626 22596 90425845
Glossodynia 465.24 9.81 49 179957 321730 90126711
Maternal exposure during pregnancy 463.24 9.81 79 179927 359984 90088457
Infusion related reaction 460.36 9.81 129 179877 416651 90031790
Haematemesis 451.81 9.81 438 179568 33288 90415153
Pericarditis 451.53 9.81 20 179986 270131 90178310
Rhabdomyolysis 420.53 9.81 514 179492 50742 90397699
Coronary artery occlusion 417.96 9.81 242 179764 8312 90440129
Drug intolerance 413.41 9.81 186 179820 447405 90001036
Treatment failure 408.28 9.81 59 179947 303869 90144572
Duodenal ulcer perforation 396.04 9.81 9 179997 221279 90227162
Drug ineffective 388.22 9.81 1432 178574 1382866 89065575
Helicobacter infection 385.06 9.81 15 179991 226835 90221606
Folliculitis 375.04 9.81 6 180000 204347 90244094
Alopecia 370.97 9.81 266 179740 494805 89953636
Epistaxis 367.04 9.81 629 179377 84496 90363945
Subdural haematoma 364.33 9.81 286 179720 16359 90432082
Haemorrhage 363.55 9.81 560 179446 68809 90379632
Arthropathy 362.67 9.81 137 179869 366105 90082336
Vascular stent thrombosis 357.25 9.81 119 179887 997 90447444
Joint swelling 346.01 9.81 295 179711 503005 89945436
Acute coronary syndrome 344.09 9.81 233 179773 10580 90437861
Therapeutic product effect decreased 333.39 9.81 72 179934 277499 90170942
Off label use 330.69 9.81 1107 178899 1101145 89347296
Haematochezia 329.69 9.81 542 179464 70371 90378070
Rheumatoid factor positive 324.05 9.81 3 180003 171647 90276794
Contraindicated product administered 321.55 9.81 117 179889 320022 90128419
Fall 321.39 9.81 1839 178167 479971 89968470
Haemorrhage intracranial 320.00 9.81 255 179751 14907 90433534
Wound 319.43 9.81 102 179904 302878 90145563
Muscle injury 316.80 9.81 7 179999 176647 90271794
Psoriatic arthropathy 312.06 9.81 42 179964 228293 90220148
Hepatic enzyme increased 310.05 9.81 165 179841 360571 90087870
Shock haemorrhagic 308.94 9.81 229 179777 12016 90436425
Angina unstable 306.92 9.81 186 179820 6957 90441484
Irritable bowel syndrome 274.51 9.81 42 179964 207406 90241035
Discomfort 272.52 9.81 102 179904 274233 90174208
Stent placement 271.64 9.81 143 179863 4060 90444381
Thrombosis in device 270.64 9.81 129 179877 2946 90445495
Rheumatoid arthritis 268.60 9.81 197 179809 362417 90086024
Hypoglycaemia 259.84 9.81 484 179522 69364 90379077
Coronary artery stenosis 257.32 9.81 149 179857 5117 90443324
Hypotension 254.60 9.81 1298 178708 324099 90124342
Vascular pseudoaneurysm 254.52 9.81 104 179902 1619 90446822
Hyperkalaemia 249 9.81 456 179550 64508 90383933
Syncope 247.96 9.81 700 179306 131963 90316478
Haemoglobin decreased 245.71 9.81 794 179212 161162 90287279
Rectal haemorrhage 243.66 9.81 520 179486 82224 90366217
Cerebral infarction 241.63 9.81 281 179725 26315 90422126
Swelling 238.45 9.81 289 179717 418769 90029672
Hypersensitivity 237.76 9.81 334 179672 454343 89994098
Sleep disorder due to general medical condition, insomnia type 235.16 9.81 4 180002 128690 90319751
Vascular stent stenosis 232.10 9.81 76 179930 600 90447841
Exposure during pregnancy 229.56 9.81 93 179913 238317 90210124
Product use issue 222.10 9.81 197 179809 329722 90118719
Lower gastrointestinal haemorrhage 221.43 9.81 165 179841 8727 90439714
Infection 216.43 9.81 240 179766 361854 90086587
C-reactive protein abnormal 214.24 9.81 9 179997 127420 90321021
Nasopharyngitis 204.98 9.81 307 179699 406797 90041644
Impaired healing 199.81 9.81 108 179898 234091 90214350
Eosinophilic bronchitis 199.62 9.81 67 179939 576 90447865
Pain 199.07 9.81 1164 178842 995177 89453264
Stomatitis 197.23 9.81 154 179852 274544 90173897
Ischaemic stroke 196.04 9.81 231 179775 21935 90426506
Ill-defined disorder 195.20 9.81 62 179944 184829 90263612
Fibromyalgia 191.30 9.81 85 179921 206184 90242257
Type 2 diabetes mellitus 191.27 9.81 82 179924 203162 90245279
Hyponatraemia 190.26 9.81 641 179365 132897 90315544
Intentional product use issue 189.48 9.81 97 179909 216795 90231646
Sinusitis 189.44 9.81 242 179764 342846 90105595
Liver injury 184.01 9.81 55 179951 170512 90277929
Thrombotic thrombocytopenic purpura 183.59 9.81 110 179896 4028 90444413
Ecchymosis 182.08 9.81 169 179837 12154 90436287
Facet joint syndrome 179.99 9.81 3 180003 98386 90350055
Subarachnoid haemorrhage 177.60 9.81 198 179808 17706 90430735
Abdominal discomfort 177.26 9.81 432 179574 476896 89971545
Chest pain 177.26 9.81 1164 178842 318481 90129960
Musculoskeletal stiffness 176.65 9.81 197 179809 296335 90152106
Therapeutic product effect incomplete 171.94 9.81 85 179921 193811 90254630
Arterial haemorrhage 166.35 9.81 87 179919 2436 90446005
Retroperitoneal haemorrhage 166.23 9.81 93 179913 2987 90445454
Spinal epidural haematoma 165.13 9.81 71 179935 1263 90447178
Lip dry 163.69 9.81 9 179997 100946 90347495
Arteriosclerosis 162.60 9.81 150 179856 10703 90437738
Coronary artery thrombosis 162.12 9.81 67 179939 1075 90447366
Bursitis 160.33 9.81 33 179973 131621 90316820
Multiple injuries 157.33 9.81 76 179930 1789 90446652
Joint range of motion decreased 157.13 9.81 38 179968 135605 90312836
Drug hypersensitivity 152.85 9.81 445 179561 463164 89985277
Abdominal wall haematoma 151.04 9.81 90 179916 3262 90445179
Gastrointestinal disorder 150.17 9.81 173 179833 256514 90191927
Renal failure 148.62 9.81 584 179422 130423 90318018
Pyrexia 146.79 9.81 744 179262 659741 89788700
Atrial fibrillation 146.26 9.81 589 179417 133022 90315419
Haemoptysis 145.89 9.81 248 179758 33072 90415369
Lactic acidosis 144.92 9.81 314 179692 50149 90398292
Blood loss anaemia 143.93 9.81 136 179870 10004 90438437
Rash 142.74 9.81 961 179045 795139 89653302
Bradycardia 141.78 9.81 427 179579 83420 90365021
Cardiac disorder 141.19 9.81 334 179672 56538 90391903
Myocardial ischaemia 140.87 9.81 155 179851 13659 90434782
Lower respiratory tract infection 139.14 9.81 176 179830 250483 90197958
Weight increased 135.67 9.81 404 179602 417523 90030918
Arthralgia 131.57 9.81 956 179050 777566 89670875
Product use in unapproved indication 131.37 9.81 296 179710 335940 90112501
Blister 129.49 9.81 191 179815 254807 90193634
Carotid artery stenosis 128.41 9.81 97 179909 5237 90443204
Live birth 128.41 9.81 7 179999 79100 90369341
Deep vein thrombosis postoperative 126.15 9.81 3 180003 70806 90377635
Cardiogenic shock 125.99 9.81 196 179810 24272 90424169
Cardiac failure 125.71 9.81 490 179516 109006 90339435
Blood cholesterol increased 125.14 9.81 137 179869 207875 90240566
Hemiparesis 121.45 9.81 223 179783 31596 90416845
Haemorrhagic stroke 119.75 9.81 101 179905 6395 90442046
Grip strength decreased 119.58 9.81 20 179986 92556 90355885
Coronary artery bypass 118.87 9.81 68 179938 2281 90446160
Sleep disorder 115.22 9.81 134 179872 197896 90250545
Hip arthroplasty 114.25 9.81 10 179996 76198 90372243
Wound infection 113.49 9.81 35 179971 106367 90342074
Haematuria 112.69 9.81 228 179778 34709 90413732
Mitral valve incompetence 112.60 9.81 178 179828 22346 90426095
Post procedural haematoma 110.00 9.81 54 179952 1318 90447123
Peripheral arterial occlusive disease 108.96 9.81 83 179923 4538 90443903
Blood creatine phosphokinase increased 108.51 9.81 221 179785 33802 90414639
Peripheral venous disease 106.48 9.81 19 179987 83902 90364539
Extradural haematoma 105.01 9.81 60 179946 2008 90446433
Wheezing 104.47 9.81 196 179810 237884 90210557
Obesity 103.39 9.81 40 179966 105467 90342974
Diverticulum intestinal haemorrhagic 102.81 9.81 56 179950 1705 90446736
Inflammation 102.66 9.81 122 179884 178470 90269971
Night sweats 101.82 9.81 65 179941 128701 90319740
Pulmonary fibrosis 100.10 9.81 44 179962 107459 90340982
Ischaemic cardiomyopathy 99.47 9.81 63 179943 2550 90445891
Peripheral vascular disorder 98.51 9.81 90 179916 6341 90442100
Pallor 97.42 9.81 212 179794 33953 90414488
Dislocation of vertebra 97.36 9.81 3 180003 55965 90392476
Migraine 96.25 9.81 143 179863 190249 90258192
Pregnancy 96.20 9.81 7 179999 62040 90386401
Autoimmune disorder 96.03 9.81 18 179988 76726 90371715
Pulmonary alveolar haemorrhage 93.95 9.81 85 179921 5913 90442528
International normalised ratio increased 93.59 9.81 255 179751 47061 90401380
Gastritis erosive 92.83 9.81 89 179917 6666 90441775
C-reactive protein increased 91.92 9.81 136 179870 181253 90267188
Asthenia 91.70 9.81 1529 178477 532222 89916219
Oesophageal intramural haematoma 90.49 9.81 26 179980 124 90448317
Cerebral haematoma 90.21 9.81 72 179934 4217 90444224
Myalgia 89.32 9.81 625 179381 174500 90273941
Prescribed overdose 89.26 9.81 41 179965 97584 90350857
Gastric ulcer 88.37 9.81 179 179827 27269 90421172
Eosinophil count increased 88.09 9.81 119 179887 12962 90435479
Cardiac arrest 87.81 9.81 427 179579 104508 90343933
Intraventricular haemorrhage 87.73 9.81 57 179949 2412 90446029
Lower limb fracture 87.07 9.81 30 179976 84983 90363458
Duodenal ulcer 86.88 9.81 101 179905 9451 90438990
Liver function test increased 86.81 9.81 30 179976 84825 90363616
Post procedural haemorrhage 86.75 9.81 97 179909 8701 90439740
Cardiovascular disorder 86.72 9.81 120 179886 13372 90435069
Hallucination 86.39 9.81 308 179698 65651 90382790
Knee arthroplasty 85.81 9.81 29 179977 83153 90365288
Faeces discoloured 84.64 9.81 152 179854 21168 90427273
Sciatica 84.60 9.81 48 179958 101334 90347107
Loss of consciousness 84.58 9.81 522 179484 139716 90308725
Retroperitoneal haematoma 82.75 9.81 62 179944 3306 90445135
Mobility decreased 82.27 9.81 241 179765 250493 90197948
Circulatory collapse 82.07 9.81 164 179842 24740 90423701
Tachyarrhythmia 81.53 9.81 75 179931 5331 90443110
Gastric haemorrhage 79.98 9.81 84 179922 7019 90441422
Arteriosclerosis coronary artery 79.85 9.81 97 179909 9506 90438935
Haemarthrosis 79.66 9.81 65 179941 3929 90444512
Intestinal haemorrhage 79.63 9.81 68 179938 4379 90444062
Chronic obstructive pulmonary disease 79.58 9.81 324 179682 73505 90374936
Onychomadesis 78.13 9.81 3 180003 45995 90402446
Presyncope 78.08 9.81 186 179820 31619 90416822
Osteoarthritis 77.45 9.81 171 179835 195559 90252882
Coronary artery restenosis 77.38 9.81 28 179978 307 90448134
X-ray abnormal 77.03 9.81 3 180003 45421 90403020
Abortion spontaneous 76.08 9.81 9 179997 54047 90394394
Gastritis 75.68 9.81 218 179788 41535 90406906
Dyspnoea 75.68 9.81 2286 177720 878669 89569772
Neutrophilia 75.41 9.81 74 179932 5704 90442737
Subdural haemorrhage 75.29 9.81 59 179947 3364 90445077
Condition aggravated 75.22 9.81 788 179218 594757 89853684
Diabetes mellitus inadequate control 75.19 9.81 134 179872 18550 90429891
Gait inability 74.99 9.81 109 179897 146347 90302094
Febrile neutropenia 74.27 9.81 125 179881 158224 90290217
Arterial stenosis 74.23 9.81 34 179972 707 90447734
Abnormal loss of weight 73.84 9.81 79 179927 6744 90441697
Polyp 73.19 9.81 83 179923 7561 90440880
Peripheral ischaemia 72.88 9.81 72 179934 5595 90442846
Tricuspid valve incompetence 72.54 9.81 124 179882 16607 90431834
Injection site reaction 72.08 9.81 47 179959 92033 90356408
Product administration error 71.99 9.81 161 179845 26262 90422179
Aortic arteriosclerosis 71.15 9.81 82 179924 7602 90440839
Dysarthria 71.00 9.81 254 179752 54228 90394213
Dehydration 70.66 9.81 642 179364 193805 90254636
Injury 70.47 9.81 182 179824 197167 90251274
Angioplasty 70.07 9.81 41 179965 1436 90447005
Dizziness 69.59 9.81 1595 178411 587689 89860752
Cardiac tamponade 69.56 9.81 70 179936 5562 90442879
Internal haemorrhage 69.05 9.81 73 179933 6147 90442294
Skin candida 68.85 9.81 43 179963 1698 90446743
Therapy non-responder 68.76 9.81 103 179903 136601 90311840
Pemphigoid 68.36 9.81 87 179919 8939 90439502
Pericardial haemorrhage 68.36 9.81 44 179962 1832 90446609
Kidney rupture 68.21 9.81 18 179988 58 90448383
Adverse event 67.69 9.81 80 179926 117338 90331103
Red blood cell sedimentation rate increased 67.64 9.81 40 179966 82555 90365886
Ventricular fibrillation 66.11 9.81 108 179898 13936 90434505
Malignant neoplasm progression 65.79 9.81 69 179937 106801 90341640
Splenic rupture 64.89 9.81 38 179968 1333 90447108
Foot deformity 64.73 9.81 19 179987 59632 90388809
Intermittent claudication 64.57 9.81 42 179964 1781 90446660
Hypoaesthesia 64.03 9.81 364 179642 313846 90134595
Diverticulum intestinal 62.83 9.81 84 179922 9058 90439383
Traumatic haematoma 62.71 9.81 41 179965 1754 90446687
Procedural haemorrhage 62.64 9.81 51 179955 3073 90445368
Groin pain 61.71 9.81 97 179909 12116 90436325
Chronic kidney disease 61.19 9.81 229 179777 49962 90398479
Brain herniation 60.89 9.81 57 179949 4143 90444298
Loss of personal independence in daily activities 60.60 9.81 111 179895 135994 90312447
Cerebral ischaemia 60.34 9.81 73 179933 7123 90441318
Blood pressure inadequately controlled 60.30 9.81 68 179938 6156 90442285
Lymphatic fistula 60.09 9.81 37 179969 1424 90447017
Blood glucose increased 59.61 9.81 358 179648 94888 90353553
Drug abuse 59.24 9.81 46 179960 82301 90366140
Femoral hernia incarcerated 59.01 9.81 37 179969 1471 90446970
Heparin-induced thrombocytopenia 58.36 9.81 62 179944 5250 90443191
Microcytic anaemia 57.64 9.81 53 179953 3765 90444676
Peripheral artery stenosis 57.60 9.81 27 179979 593 90447848
Atrioventricular block 57.55 9.81 79 179927 8736 90439705
Coronary artery dissection 57.54 9.81 31 179975 923 90447518
Electrocardiogram ST segment elevation 57.26 9.81 54 179952 3962 90444479
Spontaneous haematoma 57.20 9.81 33 179973 1125 90447316
Coma scale abnormal 57.14 9.81 63 179943 5563 90442878
Oedema peripheral 57.08 9.81 772 179234 257143 90191298
Subarachnoid haematoma 57.07 9.81 13 179993 17 90448424
Device expulsion 57.07 9.81 7 179999 40879 90407562
Peripheral swelling 56.94 9.81 535 179471 412571 90035870
Toxicity to various agents 56.75 9.81 337 179669 287509 90160932
Mesenteric haematoma 56.69 9.81 15 179991 49 90448392
Head injury 56.68 9.81 163 179843 31025 90417416
Gastric ulcer haemorrhage 56.60 9.81 61 179945 5250 90443191
Ocular retrobulbar haemorrhage 56.50 9.81 17 179989 98 90448343
Renal impairment 55.94 9.81 380 179626 105041 90343400
Colitis ulcerative 55.57 9.81 25 179981 60241 90388200
Pulmonary oedema 55.10 9.81 257 179749 61823 90386618
Hypercholesterolaemia 54.74 9.81 72 179934 100820 90347621
Breast cancer stage II 54.73 9.81 4 180002 35330 90413111
Myelosuppression 54.72 9.81 19 179987 53572 90394869
Toxic skin eruption 54.54 9.81 106 179900 15668 90432773
Road traffic accident 54.21 9.81 81 179925 107545 90340896
Wound infection pseudomonas 53.66 9.81 39 179967 1984 90446457
Thrombosis 53.53 9.81 287 179719 72964 90375477
Cerebellar haemorrhage 53.50 9.81 36 179970 1617 90446824
Renal artery stenosis 53.32 9.81 40 179966 2137 90446304
Disease progression 53.21 9.81 148 179858 156467 90291974
Joint stiffness 53.16 9.81 46 179960 77996 90370445
Onychomycosis 53.16 9.81 6 180000 37370 90411071
Aortic valve stenosis 52.92 9.81 53 179953 4187 90444254
Dermatitis exfoliative 52.81 9.81 60 179946 5476 90442965
Vascular graft 52.24 9.81 28 179978 825 90447616
Blood pressure decreased 51.74 9.81 289 179717 74606 90373835
Urticaria 51.67 9.81 386 179620 312348 90136093
Jaundice 51.59 9.81 162 179844 32355 90416086
Pancreatic steatosis 51.33 9.81 35 179971 1607 90446834
Adverse drug reaction 51.22 9.81 96 179910 116605 90331836
Nail disorder 50.68 9.81 27 179979 59040 90389401
Exostosis 50.65 9.81 21 179985 53113 90395328
Eructation 50.30 9.81 83 179923 10799 90437642
Psoriasis 49.92 9.81 140 179866 147614 90300827
Hypomagnesaemia 49.90 9.81 170 179836 35418 90413023
Petechiae 49.89 9.81 102 179904 15639 90432802
Foetal exposure during pregnancy 49.83 9.81 12 179994 42963 90405478
Orbital compartment syndrome 49.77 9.81 15 179991 87 90448354
Hiatus hernia 49.47 9.81 136 179870 25225 90423216
Fatigue 49.32 9.81 1836 178170 1152187 89296254
Lacunar infarction 49.28 9.81 46 179960 3331 90445110
Hepatic cyst 49.26 9.81 63 179943 6505 90441936
Haemorrhage subcutaneous 49.06 9.81 46 179960 3350 90445091
Drug tolerance decreased 48.75 9.81 4 180002 32126 90416315
Facial paralysis 48.46 9.81 100 179906 15434 90433007
Gastrointestinal tract mucosal pigmentation 48.32 9.81 25 179981 684 90447757
Muscle haemorrhage 47.72 9.81 45 179961 3301 90445140
Device occlusion 47.29 9.81 74 179932 9208 90439233
Cholestasis 47.09 9.81 169 179837 36130 90412311
Disorientation 47.06 9.81 193 179813 43921 90404520
Asthma 46.94 9.81 285 179721 241875 90206566
Ischaemic cerebral infarction 46.84 9.81 32 179974 1474 90446967
Immunodeficiency 46.49 9.81 14 179992 43220 90405221
Completed suicide 46.42 9.81 141 179865 144917 90303524
Oesophageal pain 46.20 9.81 50 179956 4324 90444117
Product prescribing error 45.83 9.81 148 179858 29997 90418444
Urinary tract infection 45.74 9.81 857 179149 304775 90143666
Oesophageal spasm 45.65 9.81 44 179962 3317 90445124
Ejection fraction decreased 45.59 9.81 135 179871 26118 90422323
Large intestinal haemorrhage 45.30 9.81 32 179974 1556 90446885
Angioedema 45.25 9.81 251 179755 64625 90383816
Angiopathy 44.99 9.81 55 179951 5425 90443016
Carotid arteriosclerosis 44.98 9.81 29 179977 1211 90447230
Multiple organ dysfunction syndrome 44.78 9.81 260 179746 68076 90380365
Musculoskeletal pain 44.40 9.81 182 179824 171069 90277372
Intracardiac thrombus 43.94 9.81 37 179969 2337 90446104
Liver disorder 43.92 9.81 111 179895 121158 90327283
Duodenal ulcer haemorrhage 43.57 9.81 38 179968 2518 90445923
Lichen planopilaris 43.53 9.81 16 179990 184 90448257
Arterial occlusive disease 43.48 9.81 84 179922 12362 90436079
Insomnia 42.93 9.81 439 179567 333035 90115406
Coronary angioplasty 42.62 9.81 13 179993 79 90448362
Hypokalaemia 41.71 9.81 421 179585 130695 90317746
Gastrointestinal vascular malformation haemorrhagic 41.70 9.81 16 179990 209 90448232
Unresponsive to stimuli 41.63 9.81 168 179838 37953 90410488
Atrioventricular block complete 41.59 9.81 72 179934 9739 90438702
Lethargy 41.22 9.81 240 179766 62899 90385542
Ear infection 40.79 9.81 47 179959 69728 90378713
Finger deformity 40.55 9.81 8 179998 32889 90415552
Labile hypertension 40.49 9.81 20 179986 495 90447946
Troponin increased 39.68 9.81 84 179922 13197 90435244
Intentional overdose 39.60 9.81 79 179927 93755 90354686
Laryngitis 39.59 9.81 26 179980 50727 90397714
Frequent bowel movements 39.46 9.81 33 179973 56902 90391539
Endothelial dysfunction 39.09 9.81 15 179991 196 90448245
Haemangioma of spleen 38.94 9.81 10 179996 28 90448413
Spinal cord haemorrhage 38.47 9.81 16 179990 261 90448180
Osteoporosis 38.44 9.81 84 179922 96447 90351994
Eye haemorrhage 38.41 9.81 71 179935 10109 90438332
Dysphagia 38.39 9.81 366 179640 111912 90336529
Orthopnoea 38.36 9.81 57 179949 6778 90441663
Aortic aneurysm 37.70 9.81 45 179961 4330 90444111
Acute pulmonary oedema 37.64 9.81 68 179938 9512 90438929
Balance disorder 37.54 9.81 325 179681 96755 90351686
Disability 37.41 9.81 17 179989 40728 90407713
Dyspnoea exertional 37.41 9.81 259 179747 72029 90376412
Peripheral artery occlusion 37.29 9.81 28 179978 1498 90446943
Orbital haematoma 37.16 9.81 9 179997 18 90448423
Periorbital haematoma 37.13 9.81 22 179984 789 90447652
Aphasia 37.09 9.81 176 179830 42636 90405805
Coagulopathy 36.92 9.81 116 179890 23173 90425268
Vertigo 36.65 9.81 251 179755 69560 90378881
Lip swelling 36.61 9.81 163 179843 38447 90409994
Lung disorder 36.57 9.81 163 179843 149720 90298721
Headache 36.22 9.81 1375 178631 861371 89587070
Systemic infection 36.12 9.81 46 179960 4729 90443712
Coeliac disease 35.97 9.81 22 179984 44588 90403853
Puncture site haemorrhage 35.95 9.81 17 179989 381 90448060
Faecaloma 35.95 9.81 70 179936 10361 90438080
Blood creatinine increased 35.92 9.81 333 179673 101053 90347388
Seroma 35.91 9.81 37 179969 3023 90445418
Iron deficiency anaemia 35.82 9.81 116 179890 23546 90424895
Memory impairment 35.72 9.81 237 179769 197007 90251434
Small intestinal haemorrhage 35.21 9.81 32 179974 2239 90446202
Dry mouth 34.94 9.81 218 179788 183841 90264600
Coronary artery reocclusion 34.84 9.81 9 179997 26 90448415
Insulin autoimmune syndrome 34.80 9.81 13 179993 157 90448284
Capillary fragility test 34.59 9.81 9 179997 27 90448414
Agitation 34.49 9.81 240 179766 66858 90381583
Swollen tongue 34.21 9.81 181 179825 45775 90402666
Cytokine release syndrome 34.07 9.81 7 179999 27966 90420475
Necrotising myositis 34.06 9.81 21 179985 810 90447631
Occult blood positive 34.04 9.81 41 179965 3982 90444459
Vision blurred 33.58 9.81 351 179655 109942 90338499
Product substitution issue 33.58 9.81 95 179911 17913 90430528
Mitral valve stenosis 33.35 9.81 25 179981 1334 90447107
Pericardial effusion 33.06 9.81 153 179853 36680 90411761
Percutaneous coronary intervention 33.03 9.81 14 179992 240 90448201
Cardiac operation 33.01 9.81 40 179966 3909 90444532
Lupus-like syndrome 33.01 9.81 29 179977 48817 90399624
Hypertensive heart disease 32.95 9.81 33 179973 2607 90445834
Low density lipoprotein increased 32.55 9.81 58 179948 8027 90440414
Ischaemia 32.40 9.81 46 179960 5249 90443192
Urine output decreased 32.34 9.81 75 179931 12528 90435913
Acute left ventricular failure 32.16 9.81 24 179982 1272 90447169
Blood glucose decreased 32.04 9.81 111 179895 23318 90425123
Arterial thrombosis 31.83 9.81 26 179980 1574 90446867
Nephrogenic systemic fibrosis 31.75 9.81 40 179966 4068 90444373
Oedema 31.75 9.81 250 179756 200045 90248396
Liver function test abnormal 31.73 9.81 191 179815 50654 90397787
Hydrocephalus 31.62 9.81 49 179957 6045 90442396
Respiratory rate increased 31.40 9.81 86 179920 15915 90432526
Taste disorder 31.30 9.81 46 179960 61500 90386941
Hyperparathyroidism secondary 31.15 9.81 27 179979 1774 90446667
Therapeutic response decreased 31.06 9.81 84 179922 89645 90358796
Diverticulum 30.99 9.81 72 179934 12041 90436400
Platelet function test abnormal 30.87 9.81 10 179996 76 90448365
Hyperlipidaemia 30.85 9.81 108 179898 22808 90425633
Coagulation time prolonged 30.58 9.81 26 179980 1664 90446777
Haematoma muscle 30.53 9.81 27 179979 1823 90446618
Muscle spasticity 30.51 9.81 16 179990 35306 90413135
Embolic stroke 30.45 9.81 39 179967 4033 90444408
Anuria 30.44 9.81 81 179925 14737 90433704
Arrhythmia 30.34 9.81 165 179841 42167 90406274
Contrast encephalopathy 30.20 9.81 12 179994 173 90448268
Kounis syndrome 30.20 9.81 31 179975 2522 90445919
Skin wrinkling 30.18 9.81 24 179982 1398 90447043
Haemorrhagic transformation stroke 29.90 9.81 23 179983 1276 90447165
Traumatic intracranial haemorrhage 29.90 9.81 18 179988 665 90447776
Amblyopia 29.85 9.81 14 179992 308 90448133
Upper respiratory tract infection 29.84 9.81 142 179864 128176 90320265
Hepatorenal failure 29.56 9.81 18 179988 679 90447762
Cerebrovascular disorder 29.50 9.81 32 179974 2774 90445667
Cerebral mass effect 29.30 9.81 21 179985 1045 90447396
Sinus bradycardia 29.27 9.81 87 179919 16865 90431576
Coronary artery perforation 29.24 9.81 7 179999 13 90448428
Injection site erythema 29.23 9.81 99 179907 98403 90350038
Wound dehiscence 29.08 9.81 46 179960 5776 90442665
Pharyngeal haematoma 29.06 9.81 9 179997 58 90448383
Obstructive airways disorder 29.04 9.81 115 179891 25754 90422687
Nail ridging 29.02 9.81 16 179990 499 90447942
Left ventricular dysfunction 28.94 9.81 79 179927 14590 90433851
Blood creatine phosphokinase MB increased 28.76 9.81 22 179984 1210 90447231
Ventricular tachycardia 28.68 9.81 111 179895 24597 90423844
Mental status changes 28.62 9.81 169 179837 44510 90403931
Aortic valve incompetence 28.59 9.81 49 179957 6575 90441866
Renal injury 28.56 9.81 63 179943 10180 90438261
Tongue oedema 28.51 9.81 44 179962 5410 90443031
Prescribed underdose 28.47 9.81 67 179939 74952 90373489
Dilatation ventricular 28.38 9.81 29 179977 2347 90446094
Catheter site haematoma 28.35 9.81 12 179994 205 90448236
Duodenitis 28.33 9.81 39 179967 4324 90444117
Peripheral artery thrombosis 28.28 9.81 28 179978 2182 90446259
Left ventricular failure 28.18 9.81 49 179957 6651 90441790
Normal newborn 28.13 9.81 6 180000 23356 90425085
Product odour abnormal 28.08 9.81 24 179982 1547 90446894
Mouth haemorrhage 28.03 9.81 56 179950 8445 90439996
Orthostatic hypotension 27.96 9.81 160 179846 41667 90406774
Arthritis 27.85 9.81 206 179800 167109 90281332
Electrolyte imbalance 27.83 9.81 107 179899 23638 90424803
Bladder sphincter atony 27.78 9.81 12 179994 216 90448225
Hepatitis cholestatic 27.76 9.81 56 179950 8505 90439936
Cardiac procedure complication 27.72 9.81 11 179995 158 90448283
Cerebral hyperperfusion syndrome 27.69 9.81 7 179999 18 90448423
Back injury 27.69 9.81 31 179975 46591 90401850
Epilepsy 27.68 9.81 78 179928 82128 90366313
Duplicate therapy error 27.61 9.81 10 179996 110 90448331
Nephrosclerosis 27.57 9.81 21 179985 1148 90447293
Femoral neck fracture 27.48 9.81 62 179944 10171 90438270
Sleep disorder due to a general medical condition 27.40 9.81 29 179977 44709 90403732
Catheterisation cardiac 27.34 9.81 41 179965 4915 90443526
Chest discomfort 27.30 9.81 406 179600 137959 90310482
Bundle branch block left 27.28 9.81 53 179953 7832 90440609
Cardiac death 27.05 9.81 16 179990 572 90447869
Device inappropriate shock delivery 26.72 9.81 6 180000 7 90448434
Mucosal erosion 26.67 9.81 25 179981 1820 90446621
Intracranial aneurysm 26.61 9.81 38 179968 4360 90444081
Lacunar stroke 26.58 9.81 12 179994 241 90448200
Oesophagitis 26.50 9.81 85 179921 17164 90431277
Cardiac stress test abnormal 26.50 9.81 16 179990 594 90447847
Somnolence 26.49 9.81 572 179434 208512 90239929
Spontaneous haemorrhage 26.24 9.81 17 179989 716 90447725
Cardiomegaly 26.18 9.81 90 179916 18835 90429606
Haemothorax 26.17 9.81 28 179978 2390 90446051
Eosinophilia 25.96 9.81 119 179887 28414 90420027
Lymphocyte count decreased 25.95 9.81 19 179987 35031 90413410
Postinfarction angina 25.76 9.81 7 179999 26 90448415
Red blood cell sedimentation rate abnormal 25.73 9.81 8 179998 24196 90424245
Acid base balance abnormal 25.42 9.81 13 179993 347 90448094
Gingival bleeding 25.27 9.81 76 179930 14827 90433614
Hepatic cirrhosis 25.22 9.81 55 179951 63198 90385243
Spinal subdural haematoma 25.18 9.81 10 179996 144 90448297
Haemoperitoneum 25.14 9.81 33 179973 3495 90444946
Injection site bruising 25.08 9.81 184 179822 52123 90396318
Urinary retention 24.98 9.81 144 179862 37600 90410841
Haemodynamic instability 24.96 9.81 65 179941 11674 90436767
Muscle rupture 24.94 9.81 31 179975 3110 90445331
Rectosigmoid cancer 24.92 9.81 11 179995 209 90448232
Ear pain 24.85 9.81 48 179958 57654 90390787
Infusion site reaction 24.83 9.81 4 180002 19035 90429406
Respiratory tract haemorrhage 24.76 9.81 14 179992 459 90447982
Cachexia 24.74 9.81 47 179959 6831 90441610
Blood potassium increased 24.73 9.81 94 179912 20655 90427786
Fear 24.72 9.81 81 179925 16541 90431900
Peripheral coldness 24.66 9.81 72 179934 13820 90434621
Arterial stent insertion 24.61 9.81 7 179999 32 90448409
Sedation 24.50 9.81 36 179970 48135 90400306
Acne 24.50 9.81 13 179993 28494 90419947
Oesophageal mucosal dissection 24.45 9.81 6 180000 13 90448428
Lipoprotein (a) increased 24.45 9.81 8 179998 63 90448378
Increased tendency to bruise 24.43 9.81 65 179941 11825 90436616
Basal ganglia stroke 24.29 9.81 9 179997 106 90448335
Catheter site haemorrhage 24.14 9.81 33 179973 3635 90444806
White blood cell count decreased 24.03 9.81 214 179792 166895 90281546
Speech disorder 23.98 9.81 164 179842 45421 90403020
Pustular psoriasis 23.98 9.81 4 180002 18552 90429889
Hypokinesia 23.80 9.81 77 179929 15620 90432821
Haemorrhoidal haemorrhage 23.80 9.81 40 179966 5283 90443158
Hypoglobulinaemia 23.72 9.81 10 179996 169 90448272
Hypovolaemic shock 23.71 9.81 47 179959 7047 90441394
Resuscitation 23.58 9.81 20 179986 1276 90447165
Conjunctival haemorrhage 23.48 9.81 34 179972 3950 90444491
Spinal cord compression 23.43 9.81 38 179968 4873 90443568
Sinus node dysfunction 23.31 9.81 40 179966 5372 90443069
Basal ganglia haemorrhage 23.26 9.81 16 179990 745 90447696
Bleeding time prolonged 23.23 9.81 15 179991 628 90447813
Carotid artery disease 23.09 9.81 22 179984 1635 90446806
Ventricular hypertrophy 23.06 9.81 31 179975 3360 90445081
Erosive oesophagitis 23.06 9.81 23 179983 1808 90446633
Diabetic macroangiopathy 23.02 9.81 9 179997 124 90448317
Peptic ulcer 22.98 9.81 40 179966 5435 90443006
Hypoglycaemic coma 22.93 9.81 29 179977 2961 90445480
Eosinophil count decreased 22.82 9.81 30 179976 3182 90445259
Incorrect route of product administration 22.78 9.81 41 179965 50585 90397856
COVID-19 22.65 9.81 220 179786 168623 90279818
Drug ineffective for unapproved indication 22.61 9.81 63 179943 66581 90381860
Hepatotoxicity 22.60 9.81 35 179971 45807 90402634
Sopor 22.59 9.81 103 179903 24541 90423900
Carotid artery occlusion 22.39 9.81 43 179963 6299 90442142
Soft tissue haemorrhage 22.24 9.81 11 179995 273 90448168
Drop attacks 22.19 9.81 15 179991 679 90447762
Arterial disorder 22.17 9.81 20 179986 1386 90447055
Loose tooth 22.14 9.81 32 179974 3711 90444730
Left ventricular hypertrophy 22.12 9.81 42 179964 6102 90442339
Vaginal haematoma 22.09 9.81 9 179997 139 90448302
Ocular icterus 22.06 9.81 33 179973 3947 90444494
Myopathy 22.04 9.81 68 179938 13450 90434991
Anal haemorrhage 21.81 9.81 26 179980 2498 90445943
Labyrinthitis 21.78 9.81 27 179979 2702 90445739
Haemorrhagic cholecystitis 21.75 9.81 5 180001 7 90448434
Chronic sinusitis 21.75 9.81 10 179996 23792 90424649
Pulseless electrical activity 21.66 9.81 52 179954 8880 90439561
Facial nerve disorder 21.58 9.81 14 179992 591 90447850
Skin oedema 21.39 9.81 18 179988 1136 90447305
Injection site pain 21.38 9.81 231 179775 173468 90274973
Essential hypertension 21.30 9.81 42 179964 6273 90442168
Vessel puncture site haematoma 21.20 9.81 9 179997 155 90448286
Product complaint 21.18 9.81 67 179939 13433 90435008
Tongue haemorrhage 21.17 9.81 13 179993 498 90447943
Sciatic nerve palsy 21.17 9.81 6 180000 27 90448414
Atrioventricular block first degree 21.13 9.81 50 179956 8461 90439980
Sodium retention 20.99 9.81 9 179997 159 90448282
Oesophageal ulcer 20.96 9.81 37 179969 5082 90443359
Neoplasm progression 20.95 9.81 35 179971 44451 90403990
Contusion 20.91 9.81 650 179356 250566 90197875
Platelet dysfunction 20.88 9.81 8 179998 104 90448337
Brain stem stroke 20.88 9.81 12 179994 406 90448035
Post procedural complication 20.86 9.81 84 179922 18958 90429483
Rheumatoid nodule 20.85 9.81 7 179999 20159 90428282
Electrocardiogram ST segment depression 20.66 9.81 29 179977 3274 90445167
Arterial restenosis 20.64 9.81 5 180001 10 90448431
Exercise tolerance decreased 20.55 9.81 46 179960 7505 90440936
Change of bowel habit 20.53 9.81 24 179982 2259 90446182
Myocardial rupture 20.47 9.81 7 179999 64 90448377
Lymphoedema 20.43 9.81 67 179939 13686 90434755
Dialysis 20.38 9.81 59 179947 11270 90437171
Nervous system disorder 20.35 9.81 91 179915 21502 90426939
Intentional self-injury 20.33 9.81 17 179989 29317 90419124
Coagulation factor increased 20.32 9.81 5 180001 11 90448430
Tinnitus 20.31 9.81 151 179855 42951 90405490
Lichen nitidus 20.22 9.81 8 179998 114 90448327
Iliac artery occlusion 20.12 9.81 10 179996 251 90448190
Anhedonia 20.05 9.81 59 179947 11372 90437069
Blindness 20.02 9.81 105 179901 26463 90421978
Torsade de pointes 19.96 9.81 71 179935 15111 90433330
Hypertensive crisis 19.92 9.81 79 179927 17705 90430736
Embolism arterial 19.78 9.81 17 179989 1104 90447337
Myocardial necrosis marker increased 19.76 9.81 23 179983 2155 90446286
Brain stem haemorrhage 19.76 9.81 15 179991 816 90447625
Infarction 19.67 9.81 27 179979 2986 90445455
Agranulocytosis 19.66 9.81 128 179878 34874 90413567
Activated partial thromboplastin time prolonged 19.46 9.81 46 179960 7779 90440662
Euglycaemic diabetic ketoacidosis 19.44 9.81 40 179966 6161 90442280
Cerebral artery stenosis 19.44 9.81 13 179993 578 90447863
Aortic dissection 19.43 9.81 24 179982 2393 90446048
Arterial injury 19.42 9.81 11 179995 362 90448079
Treatment noncompliance 19.38 9.81 172 179834 51555 90396886
Ventricular dysfunction 19.36 9.81 30 179976 3701 90444740
Premature baby 19.35 9.81 13 179993 25064 90423377
Bacterial infection 19.31 9.81 95 179911 23349 90425092
Coronary artery embolism 19.23 9.81 9 179997 197 90448244
Hip fracture 19.22 9.81 122 179884 32955 90415486
Colitis ischaemic 19.12 9.81 61 179945 12285 90436156
Administration site discomfort 19.10 9.81 8 179998 133 90448308
Coronary ostial stenosis 19.08 9.81 7 179999 80 90448361
Toe amputation 19.02 9.81 22 179984 2047 90446394
Therapy partial responder 19.02 9.81 10 179996 22033 90426408
Helicobacter gastritis 18.96 9.81 20 179986 1680 90446761
Mucosal membrane hyperplasia 18.95 9.81 6 180000 42 90448399
Medication error 18.95 9.81 254 179752 84398 90364043
Pulmonary hypertension 18.93 9.81 147 179859 42376 90406065
Incision site haemorrhage 18.91 9.81 13 179993 605 90447836
Gastrointestinal angiodysplasia 18.87 9.81 13 179993 607 90447834
Compartment syndrome 18.86 9.81 26 179980 2886 90445555
Mitral valve calcification 18.81 9.81 17 179989 1181 90447260
Cystitis 18.76 9.81 209 179797 66509 90381932
Palmar erythema 18.72 9.81 21 179985 1890 90446551
Functional gastrointestinal disorder 18.71 9.81 35 179971 5027 90443414
Vessel perforation 18.66 9.81 4 180002 3 90448438
Ventricular hypokinesia 18.60 9.81 36 179970 5305 90443136
Hyperhidrosis 18.60 9.81 377 179629 135928 90312513
Crush syndrome 18.52 9.81 10 179996 299 90448142
Paraplegia 18.50 9.81 28 179978 3384 90445057
Dementia 18.46 9.81 95 179911 23766 90424675
Joint effusion 18.45 9.81 8 179998 19702 90428739
Cerebral atrophy 18.39 9.81 37 179969 5609 90442832
Cardio-respiratory arrest 18.31 9.81 199 179807 62941 90385500
Platelet disorder 18.28 9.81 23 179983 2336 90446105
Hemiplegia 18.27 9.81 72 179934 16088 90432353
Cardiac pacemaker insertion 18.24 9.81 32 179974 4375 90444066
Inappropriate schedule of product administration 18.21 9.81 200 179806 149733 90298708
Hepatic fibrosis 18.17 9.81 31 179975 4144 90444297
Brain compression 18.15 9.81 12 179994 523 90447918
Vascular stenosis 18.13 9.81 12 179994 524 90447917
Vaginal discharge 18.06 9.81 8 179998 19456 90428985
Hepatic haemorrhage 18.03 9.81 13 179993 653 90447788
Gastritis haemorrhagic 18.01 9.81 20 179986 1780 90446661
Anal prolapse 18 9.81 7 179999 95 90448346
Eyelid oedema 17.87 9.81 57 179949 11477 90436964
Postoperative wound infection 17.83 9.81 63 179943 13363 90435078
Angiocardiogram 17.83 9.81 6 180000 52 90448389
Cold sweat 17.79 9.81 65 179941 14016 90434425
Suicide attempt 17.79 9.81 83 179923 75316 90373125
No adverse event 17.76 9.81 72 179934 67910 90380531
Ruptured cerebral aneurysm 17.69 9.81 12 179994 546 90447895
Choroidal haemorrhage 17.63 9.81 6 180000 54 90448387
Intra-abdominal haemorrhage 17.59 9.81 24 179982 2638 90445803
Blood urea increased 17.56 9.81 112 179894 30301 90418140
Arteriospasm coronary 17.54 9.81 34 179972 5016 90443425
Aortic thrombosis 17.49 9.81 17 179989 1295 90447146
Cerebellar infarction 17.47 9.81 22 179984 2236 90446205
Chromaturia 17.44 9.81 80 179926 19107 90429334
Cerebral artery thrombosis 17.42 9.81 11 179995 443 90447998
Gastrointestinal arteriovenous malformation 17.37 9.81 12 179994 563 90447878
Genital erosion 17.22 9.81 11 179995 452 90447989
Drug tolerance 17.21 9.81 7 179999 17909 90430532
Carotid bruit 17.16 9.81 13 179993 705 90447736
Therapeutic response increased 17.11 9.81 11 179995 457 90447984
Cardiac valve disease 17.08 9.81 32 179974 4603 90443838
Foetal death 17.01 9.81 10 179996 20713 90427728
Vascular occlusion 16.99 9.81 16 179990 1172 90447269
Vascular stent occlusion 16.99 9.81 6 180000 61 90448380
Arteriogram coronary abnormal 16.86 9.81 4 180002 7 90448434
Intra-abdominal haematoma 16.77 9.81 21 179985 2123 90446318
Abdominal pain lower 16.73 9.81 110 179896 30067 90418374
Noninfective gingivitis 16.70 9.81 21 179985 2132 90446309
Intestinal ischaemia 16.70 9.81 47 179959 8836 90439605
Retinal haemorrhage 16.69 9.81 36 179970 5728 90442713
Hepatitis toxic 16.67 9.81 28 179978 3697 90444744
Obstructive shock 16.65 9.81 6 180000 65 90448376
Haemophagocytic lymphohistiocytosis 16.63 9.81 5 180001 15454 90432987
Binocular eye movement disorder 16.59 9.81 5 180001 29 90448412
Chronic fatigue syndrome 16.59 9.81 18 179988 1561 90446880
Sensorimotor disorder 16.58 9.81 13 179993 742 90447699
Cerebral artery occlusion 16.57 9.81 15 179991 1044 90447397
Hallucination, visual 16.54 9.81 90 179916 23002 90425439
Coagulation time abnormal 16.48 9.81 6 180000 67 90448374
Haemorrhagic erosive gastritis 16.47 9.81 11 179995 488 90447953
Dilatation atrial 16.45 9.81 20 179986 1961 90446480
Acquired haemophilia 16.45 9.81 15 179991 1054 90447387
Abortion missed 16.45 9.81 20 179986 1962 90446479
Hypophagia 16.43 9.81 125 179881 35812 90412629
Osteitis 16.40 9.81 28 179978 3745 90444696
Death 16.37 9.81 1084 178922 455467 89992974
Spondylitis 16.36 9.81 4 180002 14174 90434267
Vitreous haemorrhage 16.34 9.81 23 179983 2603 90445838
Tongue haematoma 16.31 9.81 7 179999 124 90448317
Non-small cell lung cancer recurrent 16.26 9.81 7 179999 125 90448316
Splenic haematoma 16.26 9.81 7 179999 125 90448316
Thalamic infarction 16.21 9.81 11 179995 501 90447940
Interventricular septum rupture 16.20 9.81 4 180002 9 90448432
Troponin T increased 16.18 9.81 18 179988 1605 90446836
Blood triglycerides increased 16.12 9.81 62 179944 13699 90434742
Extravasation blood 16.10 9.81 7 179999 128 90448313
Exercise tolerance increased 16.04 9.81 5 180001 33 90448408
Intracranial mass 16.03 9.81 16 179990 1259 90447182
Renal haemorrhage 15.99 9.81 15 179991 1093 90447348
Potentiating drug interaction 15.99 9.81 35 179971 5627 90442814
Muscle abscess 15.98 9.81 10 179996 396 90448045
Pharyngeal haemorrhage 15.95 9.81 12 179994 644 90447797
Lip infection 15.91 9.81 7 179999 132 90448309
Brain contusion 15.80 9.81 12 179994 653 90447788
Hypoglycaemic unconsciousness 15.72 9.81 13 179993 801 90447640
Mastocytic enterocolitis 15.67 9.81 3 180003 0 90448441
Hypothrombinaemia 15.67 9.81 3 180003 0 90448441
Puncture site swelling 15.67 9.81 3 180003 0 90448441
Malabsorption from application site 15.67 9.81 3 180003 0 90448441
Vascular stent insertion 15.63 9.81 4 180002 11 90448430
Haematotoxicity 15.55 9.81 3 180003 12532 90435909
Pain assessment 15.55 9.81 5 180001 37 90448404
Respiratory alkalosis 15.54 9.81 26 179980 3422 90445019
Anal stenosis 15.53 9.81 11 179995 537 90447904
Acute myeloid leukaemia 15.53 9.81 11 179995 20629 90427812
Implant site haematoma 15.53 9.81 6 180000 80 90448361
Gastric antral vascular ectasia 15.51 9.81 13 179993 816 90447625
Electrocardiogram ST-T change 15.51 9.81 14 179992 971 90447470
Hepatic infarction 15.47 9.81 12 179994 674 90447767
Ligament pain 15.46 9.81 8 179998 219 90448222
Anal polyp 15.46 9.81 6 180000 81 90448360
Haemorrhagic diathesis 15.43 9.81 34 179972 5490 90442951
Neurotoxicity 15.43 9.81 12 179994 21455 90426986
Eyelid retraction 15.39 9.81 6 180000 82 90448359
Quadriparesis 15.38 9.81 22 179984 2527 90445914
Brown-Sequard syndrome 15.37 9.81 4 180002 12 90448429
Nail discolouration 15.35 9.81 25 179981 3217 90445224
Inappropriate antidiuretic hormone secretion 15.33 9.81 78 179928 19427 90429014
Suicidal ideation 15.32 9.81 85 179921 73770 90374671
Neutropenic sepsis 15.31 9.81 74 179932 18056 90430385
Adverse reaction 15.31 9.81 22 179984 29690 90418751
Pituitary apoplexy 15.31 9.81 7 179999 145 90448296
Cerebrovascular insufficiency 15.26 9.81 6 180000 84 90448357
Injection site swelling 15.25 9.81 64 179942 59775 90388666
Urinary straining 15.21 9.81 5 180001 40 90448401
Premature delivery 15.21 9.81 34 179972 38728 90409713
Haemodialysis 15.20 9.81 45 179961 8702 90439739
Caesarean section 15.20 9.81 9 179997 18568 90429873
Vascular purpura 15.18 9.81 18 179988 1720 90446721
Gastrointestinal ulcer 15.15 9.81 23 179983 2788 90445653
Rales 15.14 9.81 67 179939 15760 90432681
Mediastinal haematoma 15.13 9.81 6 180000 86 90448355
Foot amputation 15.13 9.81 9 179997 325 90448116
Haematocrit decreased 15.11 9.81 138 179868 41694 90406747
Spinal fusion surgery 15.11 9.81 3 180003 12280 90436161
Metastases to bone 15.10 9.81 17 179989 25488 90422953
Metastases to central nervous system 15.07 9.81 8 179998 17534 90430907
Pituitary haemorrhage 15.07 9.81 6 180000 87 90448354
Vascular pseudoaneurysm ruptured 15.07 9.81 6 180000 87 90448354
Angiogram 15.01 9.81 6 180000 88 90448353
Hypochromic anaemia 15.00 9.81 20 179986 2151 90446290
Polymyositis 14.94 9.81 20 179986 2159 90446282
Cardiac failure chronic 14.93 9.81 34 179972 5612 90442829
Aplastic anaemia 14.91 9.81 59 179947 13210 90435231
Walking aid user 14.89 9.81 30 179976 35476 90412965
Nikolsky's sign 14.77 9.81 6 180000 92 90448349
Parkinsonian rest tremor 14.72 9.81 7 179999 159 90448282
Diabetic foot infection 14.70 9.81 8 179998 243 90448198
Inflammatory marker increased 14.70 9.81 46 179960 9168 90439273
Chest expansion decreased 14.69 9.81 5 180001 45 90448396
Autoimmune myositis 14.67 9.81 9 179997 344 90448097
Eosinophilic colitis 14.61 9.81 8 179998 246 90448195
Eyelid bleeding 14.60 9.81 5 180001 46 90448395
Intentional product misuse 14.58 9.81 111 179895 89493 90358948
Multiple sclerosis relapse 14.56 9.81 54 179952 52251 90396190
Visual field defect 14.55 9.81 39 179967 7127 90441314
Product quality issue 14.51 9.81 95 179911 79230 90369211
Haemorrhagic thyroid cyst 14.49 9.81 4 180002 16 90448425
Thalamus haemorrhage 14.48 9.81 12 179994 741 90447700
Urinary bladder haemorrhage 14.47 9.81 15 179991 1234 90447207
Necrosis 14.47 9.81 37 179969 6573 90441868
Affect lability 14.43 9.81 9 179997 18054 90430387
Sudden visual loss 14.41 9.81 5 180001 48 90448393
Cytomegalovirus infection 14.41 9.81 19 179987 26583 90421858
Diabetic retinopathy 14.41 9.81 22 179984 2680 90445761
Abscess neck 14.37 9.81 12 179994 749 90447692
Blood pressure abnormal 14.36 9.81 77 179929 19568 90428873
Mucosal haemorrhage 14.29 9.81 16 179990 1437 90447004
Sleep apnoea syndrome 14.27 9.81 110 179896 31637 90416804
Electrocardiogram abnormal 14.27 9.81 49 179957 10249 90438192
Vascular insufficiency 14.21 9.81 8 179998 260 90448181
Nuchal rigidity 14.20 9.81 12 179994 762 90447679
Urinary incontinence 14.12 9.81 125 179881 37441 90411000
Atheroembolism 14.11 9.81 4 180002 18 90448423
Exsanguination 14.11 9.81 4 180002 18 90448423
Cardiorenal syndrome 14.06 9.81 14 179992 1098 90447343
Mallory-Weiss syndrome 14.06 9.81 17 179989 1658 90446783
Hepatic necrosis 14.05 9.81 36 179970 6402 90442039
Altered state of consciousness 14.03 9.81 109 179897 31423 90417018
Subcutaneous haematoma 14.02 9.81 18 179988 1865 90446576
Delirium 13.98 9.81 136 179870 104223 90344218
Evans syndrome 13.98 9.81 9 179997 375 90448066
Skull fracture 13.93 9.81 15 179991 1290 90447151
Fracture 13.82 9.81 83 179923 21993 90426448
Long QT syndrome 13.80 9.81 27 179979 4010 90444431
Normochromic normocytic anaemia 13.80 9.81 31 179975 5071 90443370
Microangiopathy 13.74 9.81 17 179989 1698 90446743
Pancreatitis acute 13.74 9.81 110 179896 32005 90416436
Cholestatic liver injury 13.72 9.81 26 179980 3771 90444670
Pulmonary haemorrhage 13.72 9.81 41 179965 7972 90440469
Oesophagitis ulcerative 13.65 9.81 12 179994 804 90447637
Intracranial haematoma 13.64 9.81 9 179997 391 90448050
Blindness unilateral 13.64 9.81 40 179966 7696 90440745
Underdose 13.62 9.81 58 179948 53959 90394482
Myoglobinaemia 13.61 9.81 4 180002 21 90448420
Arterial rupture 13.60 9.81 9 179997 393 90448048
Vascular access site haematoma 13.60 9.81 3 180003 3 90448438
Macular degeneration 13.55 9.81 35 179971 37935 90410506
Escherichia infection 13.51 9.81 65 179941 15830 90432611
Glomerular filtration rate decreased 13.51 9.81 68 179938 16864 90431577
Tenosynovitis 13.50 9.81 6 180000 14561 90433880
Hypochloraemia 13.49 9.81 21 179985 2601 90445840
Aneurysm repair 13.45 9.81 4 180002 22 90448419
Respiratory failure 13.44 9.81 319 179687 118099 90330342
Wound haemorrhage 13.43 9.81 22 179984 2845 90445596
Urine glucose/creatinine ratio increased 13.42 9.81 7 179999 195 90448246
Visual acuity reduced 13.39 9.81 86 179920 23324 90425117
Cystitis noninfective 13.34 9.81 15 179991 1354 90447087
Language disorder 13.31 9.81 21 179985 2631 90445810
Subcapsular splenic haematoma 13.30 9.81 4 180002 23 90448418
Iliac vein occlusion 13.30 9.81 4 180002 23 90448418
Skin laceration 13.30 9.81 93 179913 25942 90422499
Cerebral artery embolism 13.27 9.81 13 179993 1000 90447441
Vessel puncture site haemorrhage 13.27 9.81 6 180000 121 90448320
Acute respiratory failure 13.25 9.81 137 179869 42781 90405660
Premature labour 13.22 9.81 5 180001 13371 90435070
Post cardiac arrest syndrome 13.16 9.81 4 180002 24 90448417
Vascular graft occlusion 13.13 9.81 7 179999 204 90448237
Forced vital capacity abnormal 13.12 9.81 5 180001 64 90448377
Bronchiectasis 13.09 9.81 15 179991 22315 90426126
Kidney fibrosis 13.07 9.81 19 179987 2215 90446226
Oral papilloma 13.05 9.81 5 180001 65 90448376
Hemianopia homonymous 13.04 9.81 12 179994 853 90447588
Atrial thrombosis 13 9.81 19 179987 2226 90446215
Drug dependence 12.97 9.81 24 179982 29303 90419138
Documented hypersensitivity to administered product 12.95 9.81 11 179995 703 90447738
Facial paresis 12.94 9.81 26 179980 3937 90444504
Urticarial vasculitis 12.93 9.81 13 179993 1032 90447409
Device dislocation 12.86 9.81 27 179979 31455 90416986
Wound haematoma 12.85 9.81 5 180001 68 90448373
Retinal artery occlusion 12.83 9.81 19 179987 2252 90446189
Hepatitis 12.79 9.81 85 179921 70654 90377787
Vaginal haemorrhage 12.78 9.81 106 179900 31165 90417276
Stevens-Johnson syndrome 12.77 9.81 101 179905 29275 90419166
Chronic gastritis 12.76 9.81 25 179981 3716 90444725
Duodenal vascular ectasia 12.74 9.81 3 180003 5 90448436
Retinal detachment 12.73 9.81 36 179970 6786 90441655
Skin induration 12.62 9.81 23 179983 3239 90445202
Stenosis 12.60 9.81 18 179988 2066 90446375
Device related thrombosis 12.54 9.81 18 179988 2075 90446366
Gouty arthritis 12.52 9.81 10 179996 586 90447855
Traumatic haemorrhage 12.51 9.81 10 179996 587 90447854
Pleural effusion 12.50 9.81 301 179705 111690 90336751
Feeling abnormal 12.43 9.81 427 179579 166808 90281633
Macroangiopathy 12.39 9.81 7 179999 229 90448212
Haemorrhagic arteriovenous malformation 12.39 9.81 6 180000 142 90448299
Embolic cerebral infarction 12.36 9.81 10 179996 597 90447844
Lumbar radiculopathy 12.30 9.81 20 179986 2571 90445870
Respiratory tract infection 12.25 9.81 68 179938 59010 90389431
Gastrointestinal ulcer haemorrhage 12.22 9.81 12 179994 926 90447515
Metastases to lymph nodes 12.18 9.81 4 180002 11685 90436756
Skin fissures 12.18 9.81 14 179992 20795 90427646
Neutropenia 12.09 9.81 347 179659 224557 90223884
Regurgitation 12.07 9.81 18 179988 2148 90446293
Rash vesicular 12.06 9.81 11 179995 18186 90430255
Posterior reversible encephalopathy syndrome 12.05 9.81 16 179990 22323 90426118
Food allergy 12.04 9.81 20 179986 25458 90422983
Aldolase increased 12.02 9.81 6 180000 152 90448289
Shock 12.00 9.81 98 179908 28680 90419761
Thrombotic cerebral infarction 11.99 9.81 7 179999 244 90448197
Extremity necrosis 11.97 9.81 17 179989 1940 90446501
Large intestinal ulcer 11.96 9.81 25 179981 3892 90444549
Intracranial haemangioma 11.96 9.81 4 180002 34 90448407
Sepsis syndrome 11.85 9.81 12 179994 961 90447480
Suture removal 11.84 9.81 5 180001 85 90448356
Bleeding varicose vein 11.82 9.81 8 179998 363 90448078
Cardiac failure acute 11.79 9.81 51 179955 11878 90436563
Reocclusion 11.79 9.81 3 180003 8 90448433
Emotional distress 11.79 9.81 118 179888 36544 90411897
Symmetrical drug-related intertriginous and flexural exanthema 11.78 9.81 12 179994 967 90447474
Aggression 11.77 9.81 92 179914 26576 90421865
Procedural pain 11.72 9.81 31 179975 33329 90415112
Amaurosis fugax 11.70 9.81 10 179996 645 90447796
Dermatitis bullous 11.69 9.81 46 179960 10270 90438171
Post viral fatigue syndrome 11.69 9.81 7 179999 256 90448185
Bradyarrhythmia 11.68 9.81 19 179987 2442 90445999
Mouth swelling 11.68 9.81 31 179975 5631 90442810
Colonic haematoma 11.66 9.81 4 180002 37 90448404
Product monitoring error 11.61 9.81 27 179979 4517 90443924
Autoimmune hepatitis 11.61 9.81 46 179960 10305 90438136
Parkinsonism 11.59 9.81 57 179949 14008 90434433
Laryngeal oedema 11.58 9.81 35 179971 6846 90441595
Paraesthesia 11.57 9.81 394 179612 249932 90198509
Blood creatine phosphokinase MM increased 11.56 9.81 4 180002 38 90448403
Cutaneous vasculitis 11.56 9.81 36 179970 7157 90441284
Sweat gland tumour 11.54 9.81 6 180000 166 90448275
Urosepsis 11.53 9.81 77 179929 21155 90427286
Phlebitis deep 11.53 9.81 3 180003 9 90448432
Incision site haematoma 11.52 9.81 5 180001 91 90448350
Abdominal wall haemorrhage 11.50 9.81 6 180000 167 90448274
Restlessness 11.50 9.81 115 179891 35605 90412836
Periorbital haemorrhage 11.47 9.81 6 180000 168 90448273
Blood pressure increased 11.44 9.81 490 179516 196727 90251714
Prothrombin time prolonged 11.42 9.81 44 179962 9728 90438713
Metastases to lung 11.41 9.81 9 179997 15982 90432459
Deafness transitory 11.41 9.81 17 179989 2026 90446415
Aortic stenosis 11.40 9.81 33 179973 6303 90442138
Bundle branch block right 11.40 9.81 30 179976 5423 90443018
Rectal perforation 11.40 9.81 9 179997 519 90447922
Tongue dry 11.39 9.81 13 179993 1192 90447249
Muscle necrosis 11.37 9.81 11 179995 833 90447608
Lung hyperinflation 11.35 9.81 14 179992 1394 90447047
Nightmare 11.33 9.81 78 179928 21647 90426794
Leukoplakia oral 11.33 9.81 7 179999 271 90448170
Impaired work ability 11.31 9.81 13 179993 19313 90429128
Eye infection viral 11.31 9.81 6 180000 173 90448268
Platelet aggregation increased 11.29 9.81 3 180003 10 90448431
Bleeding time abnormal 11.29 9.81 3 180003 10 90448431
Cerebellar haematoma 11.27 9.81 8 179998 392 90448049
Congestive hepatopathy 11.25 9.81 21 179985 3012 90445429
Rectal cancer 11.25 9.81 18 179988 2283 90446158
Auricular haematoma 11.21 9.81 4 180002 42 90448399
Osteomyelitis 11.17 9.81 94 179912 27752 90420689
Feeling hot 11.16 9.81 100 179906 77908 90370533
Injection site pruritus 11.14 9.81 62 179944 53772 90394669
Muscle hypertrophy 11.14 9.81 5 180001 99 90448342
Injection site warmth 11.13 9.81 11 179995 17504 90430937
Hepatitis acute 11.11 9.81 47 179959 10840 90437601
Impaired quality of life 11.09 9.81 18 179988 23126 90425315
Aortic rupture 11.05 9.81 5 180001 101 90448340
Ventricle rupture 11.04 9.81 4 180002 44 90448397
Aneurysm 11.02 9.81 23 179983 3577 90444864
Hypoprothrombinaemia 11.01 9.81 8 179998 407 90448034
Wound secretion 10.99 9.81 28 179978 4962 90443479
Procedural complication 10.95 9.81 31 179975 5847 90442594
Upper respiratory tract congestion 10.90 9.81 18 179988 2344 90446097
Face injury 10.87 9.81 24 179982 3881 90444560
Skin flap necrosis 10.87 9.81 3 180003 12 90448429
Superinfection 10.87 9.81 21 179985 3091 90445350
Oxygen saturation decreased 10.84 9.81 285 179721 107198 90341243
Large intestine polyp 10.76 9.81 42 179964 9344 90439097
Rash papulosquamous 10.74 9.81 5 180001 108 90448333
Pelvic haematoma 10.74 9.81 10 179996 722 90447719
Meningorrhagia 10.69 9.81 6 180000 194 90448247
Pericarditis constrictive 10.68 9.81 9 179997 569 90447872
Superinfection fungal 10.67 9.81 3 180003 13 90448428
Capillary fragility increased 10.67 9.81 3 180003 13 90448428
Duodenal perforation 10.64 9.81 12 179994 1086 90447355
Tremor 10.62 9.81 388 179618 152785 90295656
Venous haemorrhage 10.61 9.81 7 179999 304 90448137
Implantable defibrillator insertion 10.57 9.81 9 179997 577 90447864
Nodal arrhythmia 10.57 9.81 13 179993 1290 90447151
Urinary tract infection staphylococcal 10.57 9.81 8 179998 433 90448008
Cerebral arteriosclerosis 10.57 9.81 7 179999 306 90448135
Brain stem ischaemia 10.54 9.81 5 180001 113 90448328
Sarcoidosis 10.53 9.81 4 180002 10669 90437772
Femoral nerve injury 10.51 9.81 4 180002 51 90448390
Osteopenia 10.51 9.81 80 179926 22922 90425519
Decreased activity 10.50 9.81 38 179968 8154 90440287
Haemorrhage urinary tract 10.48 9.81 12 179994 1105 90447336
Blindness cortical 10.45 9.81 9 179997 586 90447855
Diabetic neuropathy 10.42 9.81 26 179980 4548 90443893
Ageusia 10.42 9.81 61 179945 16015 90432426
Peptic ulcer haemorrhage 10.41 9.81 12 179994 1112 90447329
Diabetes mellitus 10.41 9.81 184 179822 64691 90383750
Paranoia 10.41 9.81 52 179954 12856 90435585
Tuberculosis 10.38 9.81 6 180000 12543 90435898
Allergic cough 10.38 9.81 12 179994 1116 90447325
Mastication disorder 10.38 9.81 18 179988 2438 90446003
Poor peripheral circulation 10.38 9.81 24 179982 4001 90444440
End stage renal disease 10.35 9.81 39 179967 8532 90439909
Vascular encephalopathy 10.31 9.81 10 179996 760 90447681
Varicose vein ruptured 10.31 9.81 4 180002 54 90448387
Gastrointestinal toxicity 10.30 9.81 3 180003 9464 90438977
Arterial insufficiency 10.26 9.81 6 180000 210 90448231
Putamen haemorrhage 10.23 9.81 6 180000 211 90448230
Hypertonic bladder 10.21 9.81 25 179981 4323 90444118
Oesophageal ulcer haemorrhage 10.18 9.81 8 179998 458 90447983
Faecal elastase concentration decreased 10.17 9.81 3 180003 16 90448425
Blood blister 10.16 9.81 17 179989 2238 90446203
Cardiovascular symptom 10.15 9.81 5 180001 123 90448318
Respiratory tract inflammation 10.13 9.81 9 179997 611 90447830
Aortic intramural haematoma 10.11 9.81 5 180001 124 90448317
Artery dissection 10.11 9.81 5 180001 124 90448317
Abdominal pain 10.10 9.81 915 179091 394806 90053635
Unevaluable event 10.07 9.81 159 179847 54689 90393752
Glycosylated haemoglobin increased 10.05 9.81 59 179947 15503 90432938
Basilar artery stenosis 10.01 9.81 3 180003 17 90448424
Anal sphincter atony 9.99 9.81 7 179999 336 90448105
Endocarditis 9.99 9.81 34 179972 7079 90441362
Disturbance in attention 9.99 9.81 140 179866 46969 90401472
Nodal rhythm 9.97 9.81 15 179991 1803 90446638
Ear infection viral 9.97 9.81 5 180001 128 90448313
Head discomfort 9.96 9.81 61 179945 16272 90432169
Subacute cutaneous lupus erythematosus 9.95 9.81 22 179984 3560 90444881
Sinus rhythm 9.93 9.81 13 179993 1373 90447068
Fat embolism 9.92 9.81 7 179999 340 90448101
Skin weeping 9.91 9.81 19 179987 2781 90445660
AST/ALT ratio abnormal 9.90 9.81 5 180001 130 90448311
Gastric mucosal lesion 9.89 9.81 9 179997 631 90447810
Microscopic polyangiitis 9.88 9.81 6 180000 225 90448216
Blood parathyroid hormone decreased 9.88 9.81 6 180000 12210 90436231
Hepatic vein dilatation 9.87 9.81 3 180003 18 90448423
Chest wall tumour 9.86 9.81 4 180002 61 90448380
Vertebrobasilar insufficiency 9.84 9.81 6 180000 227 90448214
Hyporesponsive to stimuli 9.82 9.81 14 179992 1603 90446838

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2217.25 11.09 3000 223578 121009 42273748
Gastrointestinal haemorrhage 1379.43 11.09 2115 224463 95611 42299146
Acute myocardial infarction 1323.14 11.09 1588 224990 56577 42338180
Melaena 1270.57 11.09 1282 225296 37464 42357293
Coronary artery disease 1042.90 11.09 1355 225223 52365 42342392
Labelled drug-drug interaction medication error 721.55 11.09 625 225953 14957 42379800
Off label use 718.97 11.09 1450 225128 636885 41757872
Vascular stent thrombosis 715.31 11.09 348 226230 2894 42391863
Coronary arterial stent insertion 686.93 11.09 362 226216 3623 42391134
Angina pectoris 666.70 11.09 848 225730 32048 42362709
Cerebrovascular accident 610.37 11.09 1493 225085 95667 42299090
Upper gastrointestinal haemorrhage 595.02 11.09 769 225809 29530 42365227
Cerebral haemorrhage 527.27 11.09 828 225750 38138 42356619
Haematemesis 512.75 11.09 714 225864 29485 42365272
Thrombosis in device 511.85 11.09 275 226303 2871 42391886
Subdural haematoma 495.11 11.09 613 225965 22525 42372232
Haemorrhage 492.02 11.09 1031 225547 59532 42335225
Chest pain 469.66 11.09 1719 224859 137811 42256946
Angina unstable 458.27 11.09 423 226155 11025 42383732
Febrile neutropenia 445.82 11.09 215 226363 185488 42209269
Toxicity to various agents 400.52 11.09 377 226201 228759 42165998
Gastric haemorrhage 392.99 11.09 374 226204 10141 42384616
Haematuria 392.64 11.09 916 225662 56883 42337874
Anaemia 383.48 11.09 2675 223903 277603 42117154
Cardiac failure congestive 372.27 11.09 1150 225428 84452 42310305
Drug ineffective 357.52 11.09 1935 224643 628262 41766495
Drug abuse 357.21 11.09 63 226515 104708 42290049
Coronary artery stenosis 353.81 11.09 351 226227 10028 42384729
Rectal haemorrhage 345.51 11.09 794 225784 48812 42345945
Haematoma 340.21 11.09 567 226011 27456 42367301
Coronary artery occlusion 333.21 11.09 349 226229 10648 42384109
Haematochezia 323.97 11.09 857 225721 57579 42337178
Acute coronary syndrome 305.46 11.09 386 226192 14479 42380278
Haemorrhage intracranial 264.57 11.09 388 226190 16804 42377953
Product use in unapproved indication 261.71 11.09 359 226219 184097 42210660
Blood loss anaemia 261.64 11.09 290 226288 9446 42385311
Drug interaction 248.58 11.09 2335 224243 264664 42130093
Lower gastrointestinal haemorrhage 238.67 11.09 291 226287 10517 42384240
Epistaxis 231.79 11.09 832 225746 65994 42328763
Coronary artery restenosis 230.93 11.09 108 226470 814 42393943
Pyrexia 226.32 11.09 1203 225375 392839 42001918
Disease progression 224.10 11.09 260 226318 143396 42251361
Neutropenia 203.77 11.09 476 226102 198955 42195802
Post procedural haemorrhage 201.22 11.09 248 226330 9064 42385693
Stent placement 200.94 11.09 191 226387 5169 42389588
Faeces discoloured 200.81 11.09 340 226238 16674 42378083
Cerebral infarction 197.52 11.09 481 226097 30688 42364069
Subarachnoid haemorrhage 196.29 11.09 308 226270 14164 42380593
Syncope 193.14 11.09 1040 225538 98366 42296391
Dizziness 189.25 11.09 2091 224487 247163 42147594
Vascular stent stenosis 188.24 11.09 101 226477 1051 42393706
Haemoglobin decreased 187.39 11.09 1276 225302 131195 42263562
Foetal exposure during pregnancy 178.48 11.09 21 226557 47290 42347467
Ischaemic stroke 174.01 11.09 373 226205 21860 42372897
Therapeutic product effect incomplete 170.19 11.09 82 226496 70857 42323900
Coronary artery thrombosis 169.27 11.09 121 226457 2165 42392592
Coronary artery bypass 168.26 11.09 165 226413 4645 42390112
Transient ischaemic attack 162.32 11.09 470 226108 33269 42361488
Myocardial ischaemia 161.45 11.09 317 226261 17445 42377312
Gastritis erosive 159.93 11.09 185 226393 6318 42388439
Rhabdomyolysis 156.79 11.09 824 225754 77195 42317562
Carotid artery stenosis 156.65 11.09 168 226410 5268 42389489
Cardiac disorder 149.47 11.09 585 225993 48347 42346410
Retroperitoneal haematoma 148.56 11.09 126 226452 2925 42391832
Malignant neoplasm progression 147.61 11.09 217 226361 108183 42286574
Vascular pseudoaneurysm 144.51 11.09 118 226460 2594 42392163
COVID-19 141.99 11.09 249 226329 115699 42279058
Cytokine release syndrome 140.77 11.09 32 226546 44495 42350262
Cerebral haematoma 138.64 11.09 160 226418 5450 42389307
Hemiparesis 137.69 11.09 293 226285 17083 42377674
Arterial occlusive disease 134.31 11.09 141 226437 4312 42390445
Haemoptysis 128.30 11.09 536 226042 45631 42349126
Peripheral arterial occlusive disease 127.09 11.09 169 226409 6669 42388088
Insulin autoimmune syndrome 126.01 11.09 60 226518 473 42394284
Cardiac failure 123.96 11.09 982 225596 105874 42288883
Infusion related reaction 122.18 11.09 87 226491 60719 42334038
Death 122.13 11.09 1768 224810 469417 41925340
Duodenal ulcer haemorrhage 119.59 11.09 151 226427 5657 42389100
Shock haemorrhagic 116.35 11.09 263 226315 15979 42378778
Duodenal ulcer 113.85 11.09 221 226357 12058 42382699
Myelosuppression 113.04 11.09 37 226541 40424 42354333
Fall 111.46 11.09 1808 224770 232712 42162045
Gastric ulcer 110.58 11.09 277 226301 17985 42376772
Completed suicide 110.25 11.09 216 226362 96249 42298508
Treatment failure 109.20 11.09 103 226475 62521 42332236
Mucosal inflammation 106.84 11.09 65 226513 49309 42345448
Haemorrhagic stroke 106.63 11.09 162 226416 7240 42387517
Haemorrhagic transformation stroke 104.10 11.09 82 226496 1709 42393048
Thrombotic thrombocytopenic purpura 101.67 11.09 113 226465 3691 42391066
Intermittent claudication 100.77 11.09 93 226485 2422 42392335
Diverticulum intestinal haemorrhagic 99.02 11.09 100 226478 2919 42391838
White blood cell count decreased 97.67 11.09 283 226295 110113 42284644
Muscle haemorrhage 95.87 11.09 114 226464 4011 42390746
Product administration error 95.51 11.09 263 226315 18080 42376677
Drug intolerance 94.58 11.09 177 226401 80247 42314510
Multiple injuries 93.53 11.09 79 226499 1823 42392934
Cytomegalovirus infection 91.20 11.09 29 226549 32277 42362480
Cardiac tamponade 89.81 11.09 140 226438 6400 42388357
Drug dependence 89.80 11.09 22 226556 29072 42365685
Respiratory tract haemorrhage 89.50 11.09 68 226510 1341 42393416
Occult blood positive 88.16 11.09 111 226467 4146 42390611
Dyspnoea 87.43 11.09 3019 223559 439602 41955155
International normalised ratio increased 86.80 11.09 494 226084 47674 42347083
Subdural haemorrhage 86.77 11.09 100 226478 3401 42391356
Sepsis 86.59 11.09 662 225916 198672 42196085
Stomatitis 86.31 11.09 84 226494 50245 42344512
Iron deficiency anaemia 84.49 11.09 203 226375 12836 42381921
Loss of personal independence in daily activities 84.44 11.09 84 226494 49732 42345025
Product dose omission issue 84.00 11.09 479 226099 153886 42240871
Gastric ulcer haemorrhage 83.91 11.09 131 226447 5996 42388761
Pneumonia 83.80 11.09 1662 224916 420487 41974270
Ischaemic cardiomyopathy 83.21 11.09 135 226443 6387 42388370
Mitral valve incompetence 82.49 11.09 233 226345 16256 42378501
Myalgia 81.55 11.09 825 225753 95255 42299502
Coronary angioplasty 81.40 11.09 41 226537 370 42394387
Serotonin syndrome 80.84 11.09 19 226559 25826 42368931
Angioplasty 79.00 11.09 56 226522 988 42393769
Hypotension 78.79 11.09 1858 224720 255773 42138984
Asthenia 78.68 11.09 2001 224577 278792 42115965
Intraventricular haemorrhage 78.42 11.09 100 226478 3784 42390973
Neuropathy peripheral 77.62 11.09 279 226299 101574 42293183
Hypoglycaemia 77.16 11.09 564 226014 59290 42335467
Spinal epidural haematoma 77.04 11.09 40 226538 387 42394370
Infection 76.42 11.09 321 226257 111747 42283010
Occult blood 74.87 11.09 53 226525 933 42393824
Atrial fibrillation 74.54 11.09 1098 225480 138495 42256262
Hemiplegia 74.50 11.09 143 226435 7736 42387021
Haemobilia 74.15 11.09 40 226538 421 42394336
Pericardial haemorrhage 73.82 11.09 93 226485 3476 42391281
Pancytopenia 73.23 11.09 349 226229 117394 42277363
Condition aggravated 73.17 11.09 962 225616 259792 42134965
Retroperitoneal haemorrhage 73.00 11.09 87 226491 3068 42391689
Gingival bleeding 72.98 11.09 148 226430 8337 42386420
Pulmonary embolism 72.96 11.09 357 226221 119255 42275502
Inappropriate schedule of product administration 72.88 11.09 263 226315 95639 42299118
Gastritis 72.85 11.09 286 226292 23661 42371096
Hyphaema 72.21 11.09 46 226532 674 42394083
Cardiac aneurysm 71.76 11.09 54 226524 1049 42393708
Chest discomfort 71.73 11.09 581 225997 63035 42331722
Neutrophil count decreased 70.71 11.09 144 226434 63271 42331486
Intentional product use issue 70.41 11.09 175 226403 71658 42323099
Mallory-Weiss syndrome 70.36 11.09 61 226517 1460 42393297
Aphasia 70.35 11.09 284 226294 23799 42370958
Psychotic disorder 69.66 11.09 34 226544 29174 42365583
Vascular stent occlusion 69.55 11.09 31 226547 206 42394551
Coronary artery perforation 68.93 11.09 23 226555 58 42394699
Electrocardiogram Q wave abnormal 68.66 11.09 40 226538 494 42394263
Asthma 68.21 11.09 143 226435 62171 42332586
Fractional exhaled nitric oxide increased 67.40 11.09 61 226517 1548 42393209
Arthralgia 67.19 11.09 732 225846 204506 42190251
Ventricular tachycardia 65.74 11.09 326 226252 29834 42364923
Myocardial rupture 65.41 11.09 29 226549 190 42394567
Percutaneous coronary intervention 65.04 11.09 31 226547 245 42394512
Post procedural haematoma 64.93 11.09 60 226518 1565 42393192
Drug ineffective for unapproved indication 64.18 11.09 91 226487 46072 42348685
Peripheral artery stenosis 62.58 11.09 46 226532 861 42393896
Extradural haematoma 62.13 11.09 54 226524 1297 42393460
Premature baby 61.53 11.09 23 226555 23130 42371627
Presyncope 61.46 11.09 259 226319 22128 42372629
Haemorrhagic cholecystitis 61.29 11.09 25 226553 129 42394628
Intentional product misuse 61.29 11.09 150 226428 61750 42333007
Rheumatoid arthritis 60.67 11.09 82 226496 42358 42352399
Spinal cord haemorrhage 59.87 11.09 31 226547 298 42394459
Overdose 59.76 11.09 322 226256 104942 42289815
Vascular graft occlusion 59.64 11.09 38 226540 557 42394200
Neuroleptic malignant syndrome 59.33 11.09 20 226558 21452 42373305
Weight increased 59.29 11.09 334 226244 107649 42287108
Contraindicated product administered 59.28 11.09 279 226299 24993 42369764
Somnolence 58.25 11.09 475 226103 140630 42254127
Coronary artery dissection 58.16 11.09 30 226548 286 42394471
Myoglobin blood increased 57.94 11.09 84 226494 3598 42391159
Acquired haemophilia 57.73 11.09 57 226521 1618 42393139
Bleeding time prolonged 57.48 11.09 39 226539 639 42394118
Hepatojugular reflux 57.43 11.09 39 226539 640 42394117
Diarrhoea 57.06 11.09 1943 224635 458906 41935851
Intra-abdominal haematoma 56.73 11.09 55 226523 1526 42393231
Therapy partial responder 56.46 11.09 18 226560 20003 42374754
Suicide attempt 56.38 11.09 99 226479 46001 42348756
Contusion 56.05 11.09 399 226179 41586 42353171
Ecchymosis 56.04 11.09 126 226452 7626 42387131
Neurotoxicity 55.70 11.09 28 226550 23623 42371134
Bradycardia 55.26 11.09 696 225882 84788 42309969
Arterial restenosis 55.21 11.09 18 226560 41 42394716
Conjunctival haemorrhage 54.72 11.09 80 226498 3453 42391304
Synovitis 53.80 11.09 9 226569 15558 42379199
Neoplasm progression 53.78 11.09 45 226533 28955 42365802
Product use issue 53.45 11.09 218 226360 76533 42318224
Septic shock 53.38 11.09 278 226300 91394 42303363
Ventricular hypokinesia 53.28 11.09 115 226463 6769 42387988
Haemothorax 53.20 11.09 98 226480 5138 42389619
Electrocardiogram ST segment elevation 52.76 11.09 105 226473 5834 42388923
Duodenitis 52.73 11.09 101 226477 5455 42389302
Procedural haemorrhage 52.46 11.09 70 226508 2771 42391986
Mediastinal haematoma 52.35 11.09 21 226557 103 42394654
Bronchopulmonary aspergillosis 52.13 11.09 19 226559 19410 42375347
Arterial stenosis 51.63 11.09 46 226532 1143 42393614
Leukopenia 51.62 11.09 213 226365 74533 42320224
Sinusitis 51.36 11.09 109 226469 47183 42347574
Product prescribing error 51.17 11.09 274 226304 25838 42368919
Embolic stroke 50.79 11.09 94 226484 4946 42389811
Injury 50.62 11.09 244 226334 22072 42372685
Pulmonary haematoma 50.29 11.09 18 226560 60 42394697
Posterior reversible encephalopathy syndrome 50.10 11.09 5 226573 12816 42381941
Device occlusion 49.93 11.09 127 226451 8323 42386434
Peripheral vascular disorder 49.66 11.09 96 226482 5221 42389536
Gastrointestinal polyp haemorrhage 49.42 11.09 32 226546 483 42394274
Haemorrhagic ascites 49.01 11.09 22 226556 149 42394608
Spinal subarachnoid haemorrhage 48.91 11.09 16 226562 37 42394720
Rash 48.77 11.09 1111 225467 275843 42118914
Small intestinal haemorrhage 48.68 11.09 61 226517 2267 42392490
Sleep disorder due to a general medical condition 48.67 11.09 16 226562 17437 42377320
Dyspnoea exertional 48.64 11.09 443 226135 49705 42345052
Vascular graft 48.23 11.09 50 226528 1506 42393251
Vitreous haemorrhage 48.16 11.09 66 226512 2681 42392076
Pneumocystis jirovecii pneumonia 48.03 11.09 38 226540 25143 42369614
Blood cholesterol 47.70 11.09 24 226554 216 42394541
Splenic rupture 47.63 11.09 51 226527 1596 42393161
Kounis syndrome 47.51 11.09 73 226505 3295 42391462
Fat embolism 46.91 11.09 22 226556 167 42394590
Sedation 46.54 11.09 56 226522 30419 42364338
Peripheral ischaemia 46.43 11.09 105 226473 6380 42388377
Dyspnoea at rest 46.32 11.09 82 226496 4167 42390590
Injection site pain 46.25 11.09 155 226423 57643 42337114
Degenerative mitral valve disease 45.95 11.09 25 226553 268 42394489
Troponin increased 45.85 11.09 212 226366 18850 42375907
Multiple organ dysfunction syndrome 45.57 11.09 315 226263 96720 42298037
Haemorrhage subcutaneous 45.53 11.09 63 226515 2583 42392174
Bone marrow failure 45.25 11.09 66 226512 33027 42361730
Peripheral artery occlusion 44.99 11.09 52 226526 1774 42392983
Appendicitis 44.77 11.09 27 226551 20586 42374171
Haematoma muscle 44.43 11.09 56 226522 2094 42392663
Plantar fasciitis 43.95 11.09 67 226511 3003 42391754
Suicidal ideation 43.63 11.09 122 226456 48039 42346718
Full blood count abnormal 43.44 11.09 57 226521 29819 42364938
Systolic dysfunction 43.23 11.09 66 226512 2962 42391795
Acute myeloid leukaemia 43.20 11.09 33 226545 22223 42372534
Pallor 43 11.09 282 226296 28604 42366153
Hiatus hernia 42.85 11.09 121 226457 8439 42386318
Ejection fraction decreased 42.76 11.09 231 226347 21856 42372901
Ulcer haemorrhage 42.65 11.09 67 226511 3083 42391674
Brain natriuretic peptide increased 42.36 11.09 104 226474 6666 42388091
Petechiae 42.35 11.09 137 226441 10298 42384459
No adverse event 42.32 11.09 90 226488 38931 42355826
Haemophagocytic lymphohistiocytosis 42.27 11.09 22 226556 18200 42376557
Hyperphosphataemia 41.79 11.09 9 226569 12995 42381762
Arteriosclerosis 41.75 11.09 198 226380 17791 42376966
Microcytic anaemia 41.71 11.09 65 226513 2970 42391787
Respiratory symptom 41.70 11.09 5 226573 11101 42383656
Cardiac failure chronic 41.66 11.09 129 226449 9472 42385285
Blood phosphorus increased 41.64 11.09 8 226570 12517 42382240
Sensation of foreign body 41.04 11.09 71 226507 3542 42391215
Subcutaneous haematoma 41.00 11.09 39 226539 1056 42393701
Bacterial infection 40.73 11.09 53 226525 27826 42366931
Transplant rejection 40.54 11.09 11 226567 13577 42381180
Leriche syndrome 40.43 11.09 17 226561 96 42394661
Alopecia 40.41 11.09 58 226520 29218 42365539
Coagulation time abnormal 40.29 11.09 17 226561 97 42394660
Blood creatine phosphokinase MB increased 40.21 11.09 51 226527 1919 42392838
Gastritis haemorrhagic 40.12 11.09 47 226531 1627 42393130
Angiocardiogram 39.94 11.09 21 226557 209 42394548
Orthostatic hypotension 39.92 11.09 289 226289 30281 42364476
Blood pressure decreased 39.87 11.09 480 226098 57852 42336905
Heparin-induced thrombocytopenia 39.86 11.09 100 226478 6497 42388260
Page kidney 39.76 11.09 13 226565 30 42394727
Musculoskeletal stiffness 39.63 11.09 165 226413 57600 42337157
Impaired quality of life 39.53 11.09 13 226565 14164 42380593
Immune reconstitution inflammatory syndrome 39.52 11.09 4 226574 10139 42384618
Haemorrhage urinary tract 39.45 11.09 52 226526 2034 42392723
Ascites 39.45 11.09 161 226417 56517 42338240
N-terminal prohormone brain natriuretic peptide increased 39.41 11.09 68 226510 3385 42391372
Cytopenia 39.31 11.09 22 226556 17475 42377282
Adverse drug reaction 39.22 11.09 88 226490 37346 42357411
Helicobacter gastritis 39.21 11.09 42 226536 1315 42393442
Platelet function test abnormal 39.18 11.09 17 226561 105 42394652
Intentional overdose 39.14 11.09 141 226437 51315 42343442
Hospitalisation 39.13 11.09 233 226345 74097 42320660
Infective exacerbation of chronic obstructive airways disease 38.94 11.09 51 226527 1982 42392775
Platelet count decreased 38.89 11.09 511 226067 138070 42256687
Pathogen resistance 38.74 11.09 7 226571 11443 42383314
Dermatitis exfoliative 38.57 11.09 102 226476 6845 42387912
Head injury 38.33 11.09 213 226365 20369 42374388
Oropharyngeal pain 38.28 11.09 108 226470 42402 42352355
Cytomegalovirus viraemia 38.17 11.09 5 226573 10372 42384385
Abdominal wall haematoma 38.04 11.09 54 226524 2268 42392489
Therapeutic product effect decreased 37.87 11.09 96 226482 39054 42355703
Venoocclusive liver disease 37.80 11.09 5 226573 10297 42384460
Ischaemia 37.57 11.09 83 226495 4964 42389793
Intracardiac thrombus 37.57 11.09 55 226523 2377 42392380
Chronic kidney disease 37.37 11.09 400 226178 46841 42347916
Gastrointestinal angiodysplasia 37.18 11.09 30 226548 648 42394109
Urogenital haemorrhage 37.15 11.09 31 226547 703 42394054
Influenza 37.06 11.09 187 226391 61988 42332769
Purpura 37.04 11.09 143 226435 11736 42383021
Poisoning deliberate 36.99 11.09 5 226573 10129 42384628
Cardiac ventricular thrombosis 36.92 11.09 47 226531 1775 42392982
Oesophageal intramural haematoma 36.91 11.09 12 226566 27 42394730
Drug hypersensitivity 36.81 11.09 344 226234 99045 42295712
Wound haemorrhage 36.77 11.09 53 226525 2258 42392499
Haematotoxicity 36.55 11.09 7 226571 10978 42383779
Encephalopathy 36.49 11.09 106 226472 41227 42353530
Carotid arteriosclerosis 36.40 11.09 53 226525 2279 42392478
Immune effector cell-associated neurotoxicity syndrome 36.17 11.09 4 226574 9457 42385300
Inferior vena cava dilatation 36.15 11.09 32 226546 788 42393969
Lower respiratory tract infection 36.14 11.09 106 226472 41100 42353657
Respiratory failure 36.12 11.09 472 226106 127660 42267097
Eosinophilia 35.74 11.09 298 226280 32601 42362156
Lacunar infarction 35.65 11.09 63 226515 3197 42391560
Cytomegalovirus infection reactivation 35.39 11.09 8 226570 11170 42383587
C-reactive protein increased 35.19 11.09 196 226382 63364 42331393
Dystonia 35.19 11.09 12 226566 12778 42381979
Infarction 34.94 11.09 60 226518 2975 42391782
Haemorrhagic arteriovenous malformation 34.91 11.09 23 226555 358 42394399
Haemorrhagic infarction 34.77 11.09 26 226552 500 42394257
Gastrointestinal tract mucosal pigmentation 34.71 11.09 27 226551 552 42394205
Drug withdrawal syndrome 34.64 11.09 38 226540 21511 42373246
Cerebral mass effect 34.58 11.09 39 226539 1295 42393462
Upper respiratory tract infection 34.49 11.09 112 226466 42061 42352696
Hallucination, auditory 34.40 11.09 18 226560 14846 42379911
Insomnia 34.29 11.09 433 226145 117820 42276937
Puncture site haemorrhage 34.20 11.09 22 226556 328 42394429
Myasthenia gravis 33.86 11.09 22 226556 16115 42378642
Mouth haemorrhage 33.82 11.09 91 226487 6170 42388587
Cardiac arrest 33.49 11.09 789 225789 108531 42286226
Angiopathy 33.01 11.09 82 226496 5295 42389462
Spinal cord haematoma 32.88 11.09 15 226563 106 42394651
BK virus infection 32.87 11.09 4 226574 8780 42385977
Pulmonary vascular disorder 32.65 11.09 28 226550 660 42394097
Colitis 32.59 11.09 132 226446 46440 42348317
Haemorrhage coronary artery 32.58 11.09 10 226568 17 42394740
Carotid artery occlusion 32.39 11.09 70 226508 4124 42390633
Aggression 32.29 11.09 123 226455 44040 42350717
Anaemia macrocytic 31.76 11.09 63 226515 3492 42391265
Atrial thrombosis 31.74 11.09 51 226527 2393 42392364
Exposure during pregnancy 31.73 11.09 4 226574 8544 42386213
Stenosis 31.71 11.09 47 226531 2054 42392703
Renal haemorrhage 31.61 11.09 41 226537 1578 42393179
Atheroembolism 31.59 11.09 21 226557 332 42394425
Aspergillus infection 31.35 11.09 23 226555 15814 42378943
Shone complex 31.12 11.09 13 226565 72 42394685
Arterial intramural haematoma 31.10 11.09 12 226566 52 42394705
Tachycardia 30.88 11.09 366 226212 100721 42294036
Deep vein thrombosis 30.85 11.09 261 226317 76696 42318061
Arrhythmia 30.79 11.09 339 226239 39978 42354779
Angiodysplasia 30.71 11.09 29 226549 778 42393979
Coronary artery reocclusion 30.69 11.09 13 226565 75 42394682
Intracranial haematoma 30.37 11.09 25 226553 556 42394201
Splenic haematoma 30.36 11.09 16 226562 160 42394597
Aortic valve incompetence 30.31 11.09 90 226488 6458 42388299
Normocytic anaemia 30.30 11.09 62 226516 3515 42391242
Lymphocyte count decreased 30.27 11.09 64 226514 27745 42367012
Blood uric acid increased 30.24 11.09 23 226555 15524 42379233
Intentional self-injury 30.20 11.09 22 226556 15180 42379577
Gastrointestinal vascular malformation haemorrhagic 30.17 11.09 29 226549 796 42393961
Plasma cell myeloma 30.15 11.09 140 226438 47438 42347319
Anxiety 30.11 11.09 446 226132 118114 42276643
Fatigue 30.00 11.09 1955 224623 433686 41961071
Eosinophilic granulomatosis with polyangiitis 29.84 11.09 5 226573 8633 42386124
Migraine 29.80 11.09 56 226522 25358 42369399
Diverticulum 29.70 11.09 98 226480 7443 42387314
Alcohol poisoning 29.48 11.09 3 226575 7571 42387186
Constipation 29.37 11.09 648 225930 161643 42233114
Coagulation time prolonged 29.12 11.09 37 226541 1395 42393362
Haemorrhagic diathesis 29.08 11.09 57 226521 3132 42391625
Skin flap necrosis 28.95 11.09 8 226570 7 42394750
Catheter site haematoma 28.82 11.09 16 226562 179 42394578
Myocarditis 28.71 11.09 35 226543 18903 42375854
Cerebellar haemorrhage 28.54 11.09 40 226538 1660 42393097
Blood creatine phosphokinase increased 28.47 11.09 387 226191 47951 42346806
Nasopharyngitis 28.47 11.09 297 226281 83699 42311058
Pericardial disease 28.42 11.09 23 226555 499 42394258
Circulatory collapse 28.34 11.09 219 226359 23417 42371340
Helicobacter test positive 28.32 11.09 28 226550 796 42393961
Therapy non-responder 28.22 11.09 167 226411 53192 42341565
Pneumonia fungal 28.06 11.09 7 226571 9139 42385618
Frequent bowel movements 28 11.09 44 226534 21363 42373394
Low birth weight baby 27.98 11.09 9 226569 9946 42384811
Tricuspid valve incompetence 27.77 11.09 125 226453 10988 42383769
Lymphadenopathy 27.71 11.09 88 226490 33277 42361480
Sudden cardiac death 27.50 11.09 63 226515 3861 42390896
Oxygen saturation decreased 27.47 11.09 216 226362 64471 42330286
Respiratory syncytial virus infection 27.41 11.09 3 226575 7149 42387608
Post procedural complication 27.37 11.09 136 226442 12454 42382303
Cerebellar haematoma 27.30 11.09 16 226562 200 42394557
Forced expiratory volume decreased 27.30 11.09 4 226574 7626 42387131
Mesenteric artery thrombosis 27.22 11.09 26 226552 708 42394049
Irritability 27.18 11.09 69 226509 28059 42366698
Device related infection 27.18 11.09 41 226537 20238 42374519
Schizophrenia 27.17 11.09 11 226567 10539 42384218
Spontaneous haemorrhage 27.11 11.09 23 226555 534 42394223
Hypothyroidism 27.08 11.09 84 226494 32000 42362757
Pain 27.07 11.09 1046 225532 243802 42150955
Systemic lupus erythematosus 26.98 11.09 8 226570 9316 42385441
Loss of consciousness 26.90 11.09 662 225916 91692 42303065
Hemiataxia 26.74 11.09 10 226568 39 42394718
Ulnar nerve injury 26.72 11.09 13 226565 108 42394649
Joint swelling 26.68 11.09 232 226346 67790 42326967
Maternal exposure during pregnancy 26.55 11.09 3 226575 6975 42387782
Creatinine renal clearance decreased 26.42 11.09 59 226519 3554 42391203
Hepatic encephalopathy 26.42 11.09 29 226549 16413 42378344
Respiratory depression 26.41 11.09 37 226541 18831 42375926
Cerebral hyperperfusion syndrome 26.40 11.09 12 226566 84 42394673
Urethral haemorrhage 26.29 11.09 22 226556 501 42394256
Thrombotic cerebral infarction 26.24 11.09 21 226557 448 42394309
Bacteraemia 26.12 11.09 59 226519 24981 42369776
Vascular occlusion 26.12 11.09 29 226549 946 42393811
Herpes zoster 26.08 11.09 112 226466 38765 42355992
Hypoxia 26.06 11.09 241 226337 69545 42325212
Mitral valve disease 26.05 11.09 36 226542 1474 42393283
Amaurosis 25.81 11.09 27 226551 822 42393935
Hypophosphataemia 25.59 11.09 45 226533 20900 42373857
Catheterisation cardiac 25.55 11.09 50 226528 2744 42392013
Incision site haemorrhage 25.53 11.09 22 226556 522 42394235
Vomiting 25.38 11.09 1270 225308 288453 42106304
Cardiac discomfort 25.25 11.09 25 226553 712 42394045
Acute pulmonary oedema 25.25 11.09 102 226476 8549 42386208
Epstein-Barr virus infection 25.24 11.09 10 226568 9708 42385049
Nodule 25.08 11.09 18 226560 12516 42382241
Prostate cancer 25.07 11.09 137 226441 44506 42350251
Injection site erythema 25.02 11.09 43 226535 20152 42374605
Candida infection 25.00 11.09 48 226530 21562 42373195
Pituitary haemorrhage 24.89 11.09 15 226563 198 42394559
Accidental exposure to product 24.74 11.09 44 226534 20349 42374408
Device embolisation 24.70 11.09 9 226569 32 42394725
Colitis ulcerative 24.69 11.09 65 226513 26110 42368647
Neutropenic sepsis 24.67 11.09 29 226549 15917 42378840
Subcapsular renal haematoma 24.64 11.09 22 226556 548 42394209
Mesenteric arterial occlusion 24.61 11.09 10 226568 51 42394706
Pneumonitis 24.56 11.09 126 226452 41592 42353165
Physical examination abnormal 24.44 11.09 20 226558 441 42394316
Fungal infection 24.43 11.09 42 226536 19680 42375077
Pharyngeal haematoma 24.32 11.09 11 226567 76 42394681
Tubulointerstitial nephritis 24.29 11.09 86 226492 31462 42363295
Hypopnoea 24.24 11.09 6 226572 7876 42386881
Implant site haematoma 24.24 11.09 12 226566 104 42394653
Thrombocytopenic purpura 24.17 11.09 32 226546 1257 42393500
Peptic ulcer 24.15 11.09 55 226523 3357 42391400
Sleep disorder 24.14 11.09 153 226425 47942 42346815
Diffuse large B-cell lymphoma 24.12 11.09 10 226568 9444 42385313
Labelled drug-disease interaction medication error 24.09 11.09 13 226565 137 42394620
Intercepted product preparation error 23.98 11.09 5 226573 7384 42387373
Therapeutic response shortened 23.96 11.09 22 226556 13532 42381225
Neuralgia 23.95 11.09 64 226514 25583 42369174
Tardive dyskinesia 23.93 11.09 4 226574 6920 42387837
Electrocardiogram ST segment depression 23.85 11.09 48 226530 2689 42392068
Exostosis 23.82 11.09 75 226503 5556 42389201
Generalised tonic-clonic seizure 23.76 11.09 67 226511 26312 42368445
Aspartate aminotransferase increased 23.70 11.09 279 226299 76884 42317873
Prostatic adenoma 23.68 11.09 14 226564 178 42394579
Palmar-plantar erythrodysaesthesia syndrome 23.57 11.09 46 226532 20536 42374221
Blood bilirubin increased 23.54 11.09 130 226448 42122 42352635
Chest wall haematoma 23.36 11.09 15 226563 223 42394534
Ventricular arrhythmia 23.31 11.09 80 226498 6199 42388558
C-reactive protein abnormal 23.30 11.09 10 226568 9251 42385506
Cellulitis 23.29 11.09 212 226366 61373 42333384
Spleen ischaemia 23.28 11.09 10 226568 60 42394697
Urinary bladder haemorrhage 23.25 11.09 38 226540 1809 42392948
Incorrect route of product administration 23.19 11.09 60 226518 24245 42370512
Ischaemic nephropathy 23.07 11.09 11 226567 87 42394670
Stress 23.04 11.09 139 226439 44073 42350684
Parinaud syndrome 23.04 11.09 6 226572 3 42394754
Blood pressure fluctuation 23.03 11.09 70 226508 26838 42367919
Intestinal haemorrhage 22.94 11.09 59 226519 3892 42390865
Therapeutic response decreased 22.81 11.09 110 226468 36902 42357855
Nicotine dependence 22.81 11.09 23 226555 670 42394087
Laryngeal haemorrhage 22.79 11.09 9 226569 42 42394715
Erosive duodenitis 22.78 11.09 37 226541 1752 42393005
Arthropathy 22.57 11.09 81 226497 29516 42365241
Bladder tamponade 22.53 11.09 22 226556 616 42394141
Colonic haematoma 22.50 11.09 8 226570 26 42394731
Aortic aneurysm 22.49 11.09 91 226487 7632 42387125
Poisoning 22.45 11.09 27 226551 14672 42380085
Subacute hepatic failure 22.45 11.09 11 226567 93 42394664
Blood pressure diastolic abnormal 22.42 11.09 3 226575 6125 42388632
Nipple exudate bloody 22.41 11.09 6 226572 4 42394753
Depression 22.40 11.09 437 226141 110926 42283831
Peripheral artery bypass 22.24 11.09 10 226568 68 42394689
Aneurysm 22.20 11.09 40 226538 2061 42392696
Skin toxicity 22.16 11.09 4 226574 6545 42388212
Traumatic haematoma 22.13 11.09 24 226554 762 42393995
Hypovolaemic shock 22.09 11.09 98 226480 8561 42386196
Arterial stent insertion 22.06 11.09 11 226567 97 42394660
Multiple sclerosis relapse 22.00 11.09 26 226552 14238 42380519
Illness 21.95 11.09 64 226514 24866 42369891
Pulmonary haemorrhage 21.92 11.09 119 226459 11278 42383479
Nausea 21.92 11.09 1814 224764 394985 41999772
Tumour lysis syndrome 21.90 11.09 54 226524 22177 42372580
Eye injury 21.89 11.09 27 226551 987 42393770
Vessel puncture site haematoma 21.88 11.09 10 226568 71 42394686
Coronary revascularisation 21.88 11.09 10 226568 71 42394686
CYP2C19 polymorphism 21.84 11.09 6 226572 5 42394752
Thyroid haemorrhage 21.84 11.09 6 226572 5 42394752
Pulmonary valve disease 21.76 11.09 18 226560 403 42394354
Bronchiectasis 21.75 11.09 39 226539 17980 42376777
Colitis microscopic 21.62 11.09 50 226528 3083 42391674
Large intestine polyp 21.52 11.09 102 226476 9163 42385594
Aorta hypoplasia 21.40 11.09 11 226567 104 42394653
Encephalitis 21.33 11.09 11 226567 9147 42385610
Thalamus haemorrhage 21.32 11.09 28 226550 1091 42393666
Product shape issue 21.21 11.09 5 226573 0 42394757
Wrong dosage formulation 21.21 11.09 5 226573 0 42394757
Post transplant lymphoproliferative disorder 21.17 11.09 11 226567 9109 42385648
Brain herniation 21.11 11.09 65 226513 4758 42389999
Spontaneous haematoma 21.09 11.09 23 226555 735 42394022
Bundle branch block left 21.05 11.09 79 226499 6397 42388360
Large intestinal haemorrhage 20.99 11.09 35 226543 1694 42393063
Oesophagitis 20.98 11.09 146 226432 15101 42379656
Peptic ulcer haemorrhage 20.89 11.09 22 226556 675 42394082
Staphylococcal infection 20.88 11.09 116 226462 37527 42357230
Reperfusion injury 20.77 11.09 10 226568 81 42394676
Thoracic haemorrhage 20.76 11.09 14 226564 227 42394530
Herpes simplex 20.69 11.09 6 226572 7089 42387668
Product monitoring error 20.67 11.09 61 226517 4362 42390395
Toxic epidermal necrolysis 20.54 11.09 73 226505 26677 42368080
Gastrointestinal angiectasia 20.40 11.09 15 226563 281 42394476
Viral infection 20.33 11.09 57 226521 22426 42372331
Mitral valve hypoplasia 20.32 11.09 8 226570 37 42394720
Albumin urine present 20.32 11.09 17 226561 387 42394370
Substance abuse 20.29 11.09 11 226567 8894 42385863
Device leakage 20.28 11.09 15 226563 10270 42384487
Ear haemorrhage 20.27 11.09 27 226551 1067 42393690
Alanine aminotransferase increased 20.27 11.09 339 226239 88067 42306690
Liver function test increased 20.15 11.09 48 226530 19950 42374807
Eye haemorrhage 20.13 11.09 64 226514 4766 42389991
Myocardial necrosis marker increased 20.10 11.09 36 226542 1846 42392911
Headache 20.04 11.09 1054 225524 238315 42156442
Large intestine perforation 20.01 11.09 13 226565 9523 42385234
Cystitis haemorrhagic 19.95 11.09 7 226571 7322 42387435
Immunosuppression 19.91 11.09 10 226568 8443 42386314
Angioedema 19.91 11.09 327 226251 42150 42352607
Iliac artery stenosis 19.90 11.09 11 226567 122 42394635
Anhedonia 19.89 11.09 87 226491 7553 42387204
Carotid artery disease 19.88 11.09 24 226554 858 42393899
Pulmonary alveolar haemorrhage 19.88 11.09 141 226437 14675 42380082
Nephropathy toxic 19.83 11.09 37 226541 16801 42377956
Peripheral swelling 19.77 11.09 349 226229 89921 42304836
Chronic gastritis 19.71 11.09 39 226539 2158 42392599
Benign gastrointestinal neoplasm 19.67 11.09 11 226567 125 42394632
Gangrene 19.64 11.09 66 226512 5060 42389697
Myelodysplastic syndrome 19.59 11.09 59 226519 22686 42372071
Concomitant disease progression 19.59 11.09 42 226536 2461 42392296
Supravalvular aortic stenosis 19.50 11.09 8 226570 42 42394715
Type IIa hyperlipidaemia 19.44 11.09 15 226563 303 42394454
Product substitution error 19.41 11.09 7 226571 24 42394733
Affective disorder 19.41 11.09 4 226574 5956 42388801
Acute right ventricular failure 19.37 11.09 11 226567 129 42394628
Conjunctivitis allergic 19.18 11.09 4 226574 5907 42388850
Muscle rupture 19.16 11.09 41 226537 2399 42392358
Arteriovenous malformation 19.10 11.09 23 226555 820 42393937
Labelled drug-drug interaction issue 19.08 11.09 34 226544 1737 42393020
Cerebral artery stenosis 19.06 11.09 16 226562 366 42394391
Arteriosclerotic gangrene 19.00 11.09 9 226569 70 42394687
Respiratory arrest 18.99 11.09 82 226496 28342 42366415
Chills 18.95 11.09 369 226209 93697 42301060
Uveitis 18.91 11.09 13 226565 9245 42385512
Immune thrombocytopenia 18.87 11.09 113 226465 11103 42383654
Syringe issue 18.87 11.09 11 226567 8545 42386212
Carotid artery dissection 18.83 11.09 12 226566 176 42394581
Agitation 18.82 11.09 235 226343 64079 42330678
Gallbladder neoplasm 18.78 11.09 7 226571 27 42394730
Ankylosing spondylitis 18.76 11.09 7 226571 7049 42387708
Hyperkalaemia 18.66 11.09 560 226018 79898 42314859
Brain stem haemorrhage 18.65 11.09 25 226553 994 42393763
Neuritis 18.62 11.09 5 226573 6215 42388542
Psoriatic arthropathy 18.60 11.09 69 226509 24898 42369859
Haemarthrosis 18.55 11.09 55 226523 3943 42390814
Extrapyramidal disorder 18.51 11.09 37 226541 16375 42378382
Blood glucose increased 18.48 11.09 518 226060 73181 42321576
Escherichia infection 18.42 11.09 20 226558 11376 42383381
Ruptured cerebral aneurysm 18.37 11.09 12 226566 184 42394573
Dry eye 18.33 11.09 34 226544 15472 42379285
Reocclusion 18.31 11.09 6 226572 14 42394743
Leg amputation 18.26 11.09 42 226536 2581 42392176
Osteoporosis 18.23 11.09 32 226546 14874 42379883
Arterial disorder 18.22 11.09 28 226550 1264 42393493
Palpitations 18.20 11.09 375 226203 50422 42344335
Injection site reaction 18.12 11.09 35 226543 15686 42379071
Neutrophil count increased 18.06 11.09 50 226528 19754 42375003
Aortic dissection 17.97 11.09 46 226532 3026 42391731
Compartment syndrome 17.96 11.09 48 226530 3241 42391516
Coronary artery embolism 17.88 11.09 11 226567 151 42394606
Traumatic intracranial haemorrhage 17.88 11.09 21 226557 729 42394028
Anastomotic infection 17.85 11.09 10 226568 114 42394643
Withdrawal syndrome 17.82 11.09 32 226546 14743 42380014
Metallosis of globe 17.77 11.09 5 226573 5 42394752
Wound haematoma 17.72 11.09 8 226570 55 42394702
Rectal ulcer haemorrhage 17.61 11.09 9 226569 84 42394673
Brain stem infarction 17.61 11.09 28 226550 1302 42393455
Splenic haemorrhage 17.50 11.09 18 226560 537 42394220
Gastrointestinal ulcer 17.50 11.09 34 226544 1856 42392901
Arterial injury 17.48 11.09 16 226562 412 42394345
Product odour abnormal 17.46 11.09 23 226555 899 42393858
Blood pressure systolic abnormal 17.41 11.09 4 226574 5524 42389233
Aortic valve stenosis 17.32 11.09 45 226533 2987 42391770
Haematocoele 17.30 11.09 5 226573 6 42394751
Erosive oesophagitis 17.28 11.09 30 226548 1501 42393256
Paranoia 17.25 11.09 30 226548 13996 42380761
Mite allergy 17.25 11.09 3 226575 5043 42389714
Hypocoagulable state 17.25 11.09 24 226554 989 42393768
Mood swings 17.24 11.09 13 226565 8813 42385944
Acute kidney injury 17.15 11.09 2216 224362 365121 42029636
Retinal artery occlusion 17.14 11.09 37 226541 2178 42392579
Acute respiratory distress syndrome 17.12 11.09 92 226486 30016 42364741
Klebsiella infection 17.11 11.09 21 226557 11311 42383446
Pseudomonas infection 17.03 11.09 37 226541 15886 42378871
Accidental overdose 16.99 11.09 85 226493 28245 42366512
Carotid artery thrombosis 16.99 11.09 15 226563 368 42394389
Immunosuppressant drug level increased 16.97 11.09 10 226568 7721 42387036
Influenza virus test positive 16.93 11.09 11 226567 167 42394590
Serum ferritin abnormal 16.83 11.09 13 226565 263 42394494
Oesophagitis ulcerative 16.83 11.09 23 226555 932 42393825
Psoriasis 16.81 11.09 171 226407 48433 42346324
Aortic aneurysm rupture 16.77 11.09 25 226553 1098 42393659
Cardiac failure acute 16.72 11.09 127 226451 13506 42381251
Internal haemorrhage 16.69 11.09 65 226513 5356 42389401
Oral candidiasis 16.66 11.09 32 226546 14373 42380384
Intracranial aneurysm 16.61 11.09 32 226546 1736 42393021
Alveolitis 16.60 11.09 33 226545 1832 42392925
Haemoperitoneum 16.55 11.09 35 226543 2031 42392726
Post procedural myocardial infarction 16.54 11.09 6 226572 21 42394736
Conjunctivitis 16.54 11.09 27 226551 12912 42381845
Amaurosis fugax 16.52 11.09 20 226558 717 42394040
Mania 16.51 11.09 19 226559 10528 42384229
Increased tendency to bruise 16.51 11.09 56 226522 4314 42390443
Carotid artery stent insertion 16.48 11.09 5 226573 8 42394749
Enterococcal infection 16.46 11.09 24 226554 12015 42382742
Arterial haemorrhage 16.44 11.09 26 226552 1203 42393554
Hepatic cytolysis 16.41 11.09 80 226498 26764 42367993
Nasal congestion 16.31 11.09 91 226487 29410 42365347
Prescribed underdose 16.30 11.09 102 226476 10180 42384577
Basal ganglia haemorrhage 16.28 11.09 24 226554 1044 42393713
Rhinitis 16.26 11.09 24 226554 11953 42382804
Strangury 16.21 11.09 10 226568 138 42394619
Arteriosclerosis coronary artery 16.12 11.09 161 226417 18516 42376241
Restenosis 16.11 11.09 5 226573 9 42394748
Gastric polyps 16.06 11.09 31 226547 1684 42393073
Emotional distress 16.02 11.09 143 226435 15950 42378807
Tuberculosis 16.02 11.09 18 226560 10081 42384676
Traumatic haemothorax 15.99 11.09 15 226563 399 42394358
Dry skin 15.93 11.09 172 226406 48166 42346591
Rectal ulcer 15.87 11.09 25 226553 1153 42393604
Nocardiosis 15.87 11.09 4 226574 5186 42389571
Oesophageal ulcer 15.84 11.09 50 226528 3709 42391048
Chronic coronary syndrome 15.83 11.09 13 226565 288 42394469
Vessel puncture site haemorrhage 15.81 11.09 8 226570 73 42394684
Salivary hypersecretion 15.78 11.09 21 226557 10922 42383835
Haematocrit decreased 15.72 11.09 267 226311 34641 42360116
Aplastic anaemia 15.68 11.09 26 226552 12358 42382399
Blue toe syndrome 15.67 11.09 10 226568 147 42394610
Acute hepatic failure 15.64 11.09 43 226535 17030 42377727
Productive cough 15.62 11.09 187 226391 51380 42343377
Diastolic dysfunction 15.58 11.09 76 226502 6907 42387850
Nerve degeneration 15.52 11.09 11 226567 194 42394563
Transcatheter aortic valve implantation 15.45 11.09 5 226573 11 42394746
Haemodynamic instability 15.42 11.09 117 226461 12440 42382317
Platelet aggregation abnormal 15.37 11.09 6 226572 27 42394730
Mitral valve calcification 15.32 11.09 18 226560 625 42394132
Hepatitis cholestatic 15.29 11.09 97 226481 9727 42385030
Aortic intramural haematoma 15.28 11.09 7 226571 50 42394707
Second primary malignancy 15.26 11.09 17 226561 9558 42385199
Acne 15.19 11.09 31 226547 13613 42381144
Mucosal haemorrhage 15.13 11.09 31 226547 1759 42392998
Clostridium difficile colitis 15.01 11.09 60 226518 21192 42373565
Haemorrhagic cerebral infarction 15.01 11.09 21 226557 870 42393887
Supine hypertension 14.97 11.09 14 226564 371 42394386
Incorrect dose administered 14.96 11.09 195 226383 52779 42341978
Laboratory test abnormal 14.92 11.09 67 226511 22911 42371846
Trichoglossia 14.91 11.09 14 226564 373 42394384
Oral herpes 14.88 11.09 11 226567 7533 42387224
Vascular procedure complication 14.88 11.09 5 226573 13 42394744
Post-traumatic amnestic disorder 14.83 11.09 7 226571 54 42394703
Gingival pain 14.76 11.09 14 226564 8480 42386277
Vascular device infection 14.74 11.09 7 226571 6103 42388654
Congenital heart valve disorder 14.72 11.09 7 226571 55 42394702
Euphoric mood 14.66 11.09 8 226570 6445 42388312
Platelet aggregation decreased 14.61 11.09 5 226573 14 42394743
Left ventricular dysfunction 14.59 11.09 108 226470 11393 42383364
Gastrointestinal disorder 14.59 11.09 168 226410 46485 42348272
Skin infection 14.57 11.09 17 226561 9363 42385394
Neutropenic colitis 14.56 11.09 3 226575 4467 42390290
Anaphylactic reaction 14.53 11.09 151 226427 42592 42352165
Osteonecrosis 14.51 11.09 40 226538 15825 42378932
Haematospermia 14.46 11.09 13 226565 327 42394430
Cerebral artery occlusion 14.45 11.09 20 226558 820 42393937
Rales 14.44 11.09 107 226471 11293 42383464
Arterial bypass operation 14.40 11.09 6 226572 33 42394724
Factor V inhibition 14.39 11.09 11 226567 219 42394538
Kidney transplant rejection 14.30 11.09 15 226563 8668 42386089
Cerebrovascular disorder 14.30 11.09 31 226547 1830 42392927
Hepatitis B 14.28 11.09 9 226569 6702 42388055
Psychological trauma 14.26 11.09 11 226567 222 42394535
Haemodilution 14.25 11.09 6 226572 34 42394723
Muscle injury 14.18 11.09 29 226549 1643 42393114
Joint injury 14.18 11.09 36 226542 14640 42380117
Hyperbilirubinaemia 14.11 11.09 59 226519 20576 42374181
Myopathy 14.07 11.09 123 226455 13638 42381119
Intrapericardial thrombosis 14.01 11.09 7 226571 62 42394695
Biliary cirrhosis 13.98 11.09 10 226568 179 42394578
Drug effective for unapproved indication 13.97 11.09 9 226569 6624 42388133
Heart rate increased 13.97 11.09 199 226379 53056 42341701
Progressive multifocal leukoencephalopathy 13.90 11.09 25 226553 11511 42383246
Toxic encephalopathy 13.89 11.09 10 226568 6943 42387814
Consciousness fluctuating 13.85 11.09 25 226553 1290 42393467
Haemorrhagic disorder 13.84 11.09 19 226559 773 42393984
Paradoxical drug reaction 13.83 11.09 4 226574 4734 42390023
Hypoalbuminaemia 13.80 11.09 40 226538 15570 42379187
Catatonia 13.79 11.09 8 226570 6231 42388526
Insulin C-peptide increased 13.79 11.09 8 226570 98 42394659
Product substitution issue 13.75 11.09 105 226473 11185 42383572
Haemorrhagic erosive gastritis 13.73 11.09 11 226567 235 42394522
Non-cardiac chest pain 13.70 11.09 54 226524 4475 42390282
Cardiac operation 13.65 11.09 47 226531 3648 42391109
Oedema peripheral 13.62 11.09 868 225710 135208 42259549
Clostridium difficile infection 13.58 11.09 68 226510 22591 42372166
Anal abscess 13.57 11.09 13 226565 7837 42386920
Quadriparesis 13.55 11.09 35 226543 2315 42392442
Ileus 13.54 11.09 54 226524 19085 42375672
Meningitis 13.49 11.09 7 226571 5802 42388955
Conjunctival pallor 13.46 11.09 7 226571 68 42394689
Nail pitting 13.44 11.09 14 226564 424 42394333
Cardiovascular disorder 13.43 11.09 119 226459 13246 42381511
Psychiatric decompensation 13.41 11.09 3 226575 4219 42390538
Colorectal cancer 13.39 11.09 5 226573 5033 42389724
Brain contusion 13.39 11.09 21 226557 965 42393792
Coronary ostial stenosis 13.38 11.09 8 226570 104 42394653
Injection site oedema 13.37 11.09 13 226565 362 42394395
Lymphopenia 13.34 11.09 64 226514 21499 42373258
Dysarthria 13.33 11.09 291 226287 39516 42355241
Procedural complication 13.33 11.09 51 226527 4168 42390589
Hypochromic anaemia 13.30 11.09 22 226556 1058 42393699
Implantable defibrillator insertion 13.30 11.09 19 226559 803 42393954
Stent malfunction 13.27 11.09 5 226573 20 42394737
Hypogammaglobulinaemia 13.25 11.09 27 226551 11864 42382893
Exposure to toxic agent 13.25 11.09 5 226573 4999 42389758
Febrile bone marrow aplasia 13.24 11.09 21 226557 10160 42384597
Bundle branch block right 13.22 11.09 81 226497 8025 42386732
Right ventricular diastolic collapse 13.20 11.09 7 226571 71 42394686
Polyarthritis 13.20 11.09 58 226520 5046 42389711
Aortic valve disease 13.16 11.09 25 226553 1342 42393415
Myoglobinaemia 13.13 11.09 10 226568 198 42394559
Anti-insulin antibody increased 13.11 11.09 7 226571 72 42394685
Traumatic haemorrhage 13.10 11.09 24 226554 1253 42393504
Obsessive-compulsive disorder 13.08 11.09 10 226568 6733 42388024
Sticky platelet syndrome 13.08 11.09 5 226573 21 42394736
Crying 13.03 11.09 9 226569 6385 42388372
Sinoatrial block 13.02 11.09 15 226563 510 42394247
Drug screen positive 12.99 11.09 3 226575 4128 42390629
Cardiac valve disease 12.99 11.09 44 226534 3387 42391370
Hypereosinophilic syndrome 12.98 11.09 14 226564 442 42394315
Abscess 12.97 11.09 36 226542 14212 42380545
Cerebral ischaemia 12.94 11.09 72 226506 6887 42387870
Tongue haematoma 12.93 11.09 8 226570 111 42394646
Vascular access site haemorrhage 12.90 11.09 5 226573 22 42394735
Coeliac artery stenosis 12.90 11.09 5 226573 22 42394735
Varicophlebitis 12.90 11.09 5 226573 22 42394735
End stage renal disease 12.84 11.09 45 226533 16513 42378244
Ventricular extrasystoles 12.83 11.09 118 226460 13272 42381485
Neonatal respiratory distress syndrome 12.83 11.09 4 226574 4509 42390248
Foetal growth restriction 12.83 11.09 6 226572 5277 42389480
Aneurysm ruptured 12.74 11.09 16 226562 596 42394161
Thrombotic stroke 12.73 11.09 11 226567 262 42394495
Peripheral revascularisation 12.73 11.09 3 226575 0 42394757
Hypertrophy of tongue papillae 12.73 11.09 3 226575 0 42394757
Blood copper decreased 12.73 11.09 3 226575 0 42394757
Peripheral artery stent insertion 12.73 11.09 3 226575 0 42394757
Immunodeficiency 12.69 11.09 12 226566 7278 42387479
Ear infection 12.69 11.09 31 226547 12773 42381984
Herpes zoster cutaneous disseminated 12.67 11.09 10 226568 209 42394548
Product storage error 12.66 11.09 25 226553 11115 42383642
Anastomotic ulcer haemorrhage 12.63 11.09 6 226572 47 42394710
Coronary artery aneurysm 12.63 11.09 8 226570 116 42394641
Cardiac stress test 12.62 11.09 4 226574 8 42394749
Vitamin B6 deficiency 12.61 11.09 12 226566 325 42394432
Poor venous access 12.55 11.09 12 226566 7240 42387517
Myocardial haemorrhage 12.53 11.09 6 226572 48 42394709
Pemphigoid 12.52 11.09 104 226474 11363 42383394
Knee arthroplasty 12.51 11.09 17 226561 8764 42385993
Nephrogenic systemic fibrosis 12.47 11.09 44 226534 3457 42391300
Chromaturia 12.46 11.09 135 226443 15854 42378903
Flagellate dermatitis 12.45 11.09 8 226570 119 42394638
Peripheral venous disease 12.45 11.09 40 226538 2996 42391761
Blood pressure orthostatic abnormal 12.41 11.09 7 226571 81 42394676
Diverticulum intestinal 12.39 11.09 57 226521 5056 42389701
Intra-abdominal haemorrhage 12.39 11.09 39 226539 2889 42391868
Atrioventricular block complete 12.37 11.09 103 226475 11261 42383496
Sinus tachycardia 12.37 11.09 62 226516 20591 42374166
Skin haemorrhage 12.36 11.09 78 226500 7807 42386950
Anal fistula 12.33 11.09 9 226569 6204 42388553
Foreign body in throat 12.32 11.09 15 226563 541 42394216
Cardioactive drug level increased 12.30 11.09 28 226550 1709 42393048
Gastrointestinal toxicity 12.29 11.09 3 226575 3976 42390781
Cardiac death 12.26 11.09 22 226556 1130 42393627
Renal artery thrombosis 12.23 11.09 12 226566 338 42394419
Supraventricular tachycardia 12.22 11.09 110 226468 12298 42382459
Tooth socket haemorrhage 12.22 11.09 6 226572 51 42394706
Basal ganglia infarction 12.20 11.09 10 226568 221 42394536
Type 2 diabetes mellitus 12.18 11.09 151 226427 18320 42376437
Hepatitis C 12.17 11.09 22 226556 10111 42384646
Renal injury 12.16 11.09 109 226469 12171 42382586
Small intestinal obstruction 12.16 11.09 48 226530 17013 42377744
Hepatotoxicity 12.15 11.09 81 226497 25086 42369671
Exercise tolerance decreased 12.12 11.09 64 226514 6002 42388755
Diffuse vasculitis 12.12 11.09 7 226571 85 42394672
Pharyngeal oedema 12.11 11.09 64 226514 6004 42388753
Injection site haemorrhage 12.05 11.09 105 226473 11631 42383126
Atrioventricular block 12.04 11.09 90 226488 9525 42385232
Post procedural cellulitis 12.01 11.09 4 226574 10 42394747
Ocular hyperaemia 11.96 11.09 44 226534 15919 42378838
Injection site swelling 11.94 11.09 48 226530 16925 42377832
Parosmia 11.88 11.09 14 226564 7677 42387080
Plasma cell myeloma recurrent 11.87 11.09 8 226570 5749 42389008
Cardiac stress test abnormal 11.86 11.09 12 226566 351 42394406
Lipoprotein (a) increased 11.83 11.09 12 226566 352 42394405
Upper motor neurone lesion 11.82 11.09 9 226569 178 42394579
Brain abscess 11.82 11.09 4 226574 4280 42390477
Oesophagitis haemorrhagic 11.79 11.09 10 226568 232 42394525
Vasculitis 11.72 11.09 54 226524 18340 42376417
Drug level decreased 11.68 11.09 22 226556 9955 42384802
Enteritis 11.68 11.09 25 226553 10791 42383966
Injection site pruritus 11.68 11.09 20 226558 9385 42385372
Maternal drugs affecting foetus 11.66 11.09 3 226575 3836 42390921
Tracheal obstruction 11.65 11.09 6 226572 57 42394700
Eye disorder 11.60 11.09 28 226550 11584 42383173
Prothrombin time prolonged 11.50 11.09 88 226490 9381 42385376
Pericardial mass 11.49 11.09 4 226574 12 42394745
Peripheral artery restenosis 11.49 11.09 4 226574 12 42394745
Contrast media reaction 11.48 11.09 21 226557 1095 42393662
Haematoma evacuation 11.48 11.09 10 226568 241 42394516
Epiglottic oedema 11.45 11.09 9 226569 187 42394570
Cerebellar ischaemia 11.44 11.09 8 226570 138 42394619
High density lipoprotein decreased 11.41 11.09 46 226532 3851 42390906
Seizure 11.41 11.09 524 226054 120037 42274720
Stent-graft endoleak 11.37 11.09 5 226573 32 42394725
Ventricular enlargement 11.36 11.09 16 226562 667 42394090
Needle issue 11.35 11.09 18 226560 8709 42386048
Jugular vein distension 11.34 11.09 16 226562 668 42394089
Dyspnoea paroxysmal nocturnal 11.34 11.09 26 226552 1594 42393163
Preternatural anus 11.26 11.09 7 226571 98 42394659
COVID-19 pneumonia 11.23 11.09 68 226510 21545 42373212
Subcutaneous abscess 11.21 11.09 5 226573 4523 42390234
Bloody discharge 11.18 11.09 15 226563 597 42394160
Hyperthyroidism 11.14 11.09 121 226457 14220 42380537
Interstitial lung disease 11.13 11.09 517 226061 77945 42316812
Pneumonia cytomegaloviral 11.13 11.09 4 226574 4122 42390635
Respiratory tract infection 11.12 11.09 88 226490 26234 42368523
Folliculitis 11.10 11.09 8 226570 5550 42389207

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 4831.85 10.28 4366 349188 187717 110048028
Gastrointestinal haemorrhage 3049.37 10.28 3173 350381 162345 110073400
Acute myocardial infarction 2899.98 10.28 2291 351263 81486 110154259
Melaena 2261.16 10.28 1825 351729 66932 110168813
Coronary artery disease 2185.95 10.28 1821 351733 69869 110165876
Cerebrovascular accident 1624.58 10.28 2421 351133 178863 110056882
Labelled drug-drug interaction medication error 1396.75 10.28 972 352582 28330 110207415
Anaemia 1353.69 10.28 4330 349224 542756 109692989
Upper gastrointestinal haemorrhage 1213.94 10.28 1117 352437 48979 110186766
Coronary arterial stent insertion 1206.06 10.28 515 353039 5400 110230345
Cerebral haemorrhage 1168.72 10.28 1231 352323 63737 110172008
Vascular stent thrombosis 1134.08 10.28 446 353108 3715 110232030
Cardiac failure congestive 1039.61 10.28 1789 351765 149211 110086534
Angina pectoris 1038.89 10.28 1134 352420 61161 110174584
Haematemesis 1026.02 10.28 1099 352455 58009 110177736
Drug interaction 962.42 10.28 3644 349910 496539 109739206
Subdural haematoma 940.36 10.28 842 352712 35612 110200133
Haematoma 879.96 10.28 1009 352545 57467 110178278
Haemorrhage 873.28 10.28 1367 352187 105325 110130420
Off label use 831.93 10.28 2277 351277 1497908 108737837
Angina unstable 789.85 10.28 548 353006 15884 110219861
Synovitis 789.38 10.28 18 353536 274074 109961671
Haematochezia 749.83 10.28 1334 352220 114190 110121555
Haematuria 749.09 10.28 1113 352441 81892 110153853
Infusion related reaction 688.24 10.28 184 353370 380978 109854767
Thrombosis in device 683.16 10.28 336 353218 4991 110230754
Acute coronary syndrome 666.75 10.28 569 352985 22543 110213202
Systemic lupus erythematosus 659.57 10.28 38 353516 254300 109981445
Hand deformity 642.57 10.28 11 353543 218495 110017250
Coronary artery occlusion 614.26 10.28 463 353091 15309 110220436
Rhabdomyolysis 608.31 10.28 1250 352304 119151 110116594
Drug intolerance 605.27 10.28 271 353283 406241 109829504
Epistaxis 595.53 10.28 1299 352255 129073 110106672
Pemphigus 588.93 10.28 22 353532 214548 110021197
Coronary artery stenosis 585.47 10.28 426 353128 13332 110222413
Haemorrhage intracranial 582.53 10.28 583 352971 28386 110207359
Transient ischaemic attack 567.33 10.28 851 352703 63131 110172614
Gastric haemorrhage 560.31 10.28 440 353114 15475 110220270
Maternal exposure during pregnancy 559.34 10.28 76 353478 254807 109980938
Rectal haemorrhage 547.32 10.28 1194 352360 118639 110117106
Drug ineffective 527.07 10.28 2792 350762 1517748 108717997
Glossodynia 522.45 10.28 52 353502 221952 110013793
Alopecia 512.59 10.28 263 353291 364490 109871255
Pericarditis 511.28 10.28 53 353501 219061 110016684
Lower gastrointestinal haemorrhage 508.66 10.28 443 353111 18043 110217702
Chest pain 502.55 10.28 2457 351097 373918 109861827
Duodenal ulcer perforation 495.42 10.28 16 353538 177684 110058061
Syncope 491.67 10.28 1595 351959 200941 110034804
Treatment failure 479.60 10.28 145 353409 277089 109958656
Cerebral infarction 478.98 10.28 703 352851 51135 110184610
Folliculitis 475.03 10.28 13 353541 167640 110068105
Haemoglobin decreased 467.98 10.28 1801 351753 246926 109988819
Blood loss anaemia 452.30 10.28 410 353144 17615 110218130
Acute kidney injury 447.36 10.28 3516 350038 631914 109603831
Helicobacter infection 445.73 10.28 36 353518 181841 110053904
Joint swelling 443.33 10.28 457 353097 442388 109793357
Arthropathy 436.79 10.28 186 353368 287336 109948409
Therapeutic product effect decreased 418.57 10.28 130 353424 244186 109991559
Rheumatoid arthritis 407.69 10.28 225 353329 299388 109936357
Shock haemorrhagic 399.46 10.28 464 353090 26783 110208962
Psoriatic arthropathy 388.65 10.28 78 353476 196683 110039062
Irritable bowel syndrome 374.73 10.28 43 353511 164172 110071573
Ischaemic stroke 370.28 10.28 552 353002 40711 110195034
Hypotension 361.97 10.28 2887 350667 520962 109714783
Subarachnoid haemorrhage 359.36 10.28 459 353095 29243 110206502
Stomatitis 354.72 10.28 212 353342 270030 109965715
Vascular pseudoaneurysm 351.42 10.28 199 353355 3991 110231754
Hepatic enzyme increased 348.03 10.28 308 353246 320584 109915161
C-reactive protein abnormal 346.78 10.28 16 353538 129679 110106066
Product use in unapproved indication 341.56 10.28 565 352989 446812 109788933
Vascular stent stenosis 341.31 10.28 142 353412 1387 110234358
Haemoptysis 339.48 10.28 723 352831 70631 110165114
Febrile neutropenia 334.06 10.28 312 353242 316455 109919290
Muscle injury 333.80 10.28 32 353522 140775 110094970
Sinusitis 333.67 10.28 275 353279 296413 109939332
Therapeutic product effect incomplete 331.61 10.28 150 353404 223655 110012090
Myocardial ischaemia 328.58 10.28 416 353138 26268 110209477
Coronary artery thrombosis 324.28 10.28 173 353381 3071 110232674
Hypoglycaemia 322.95 10.28 959 352595 115145 110120600
Stent placement 321.52 10.28 230 353324 7004 110228741
Exposure during pregnancy 319.12 10.28 72 353482 167352 110068393
Fall 317.82 10.28 3134 350420 600348 109635397
Nasopharyngitis 314.25 10.28 484 353070 393877 109841868
Sleep disorder due to general medical condition, insomnia type 311.83 10.28 5 353549 105638 110130107
Faeces discoloured 311.59 10.28 459 353095 33489 110202256
Fibromyalgia 311.08 10.28 81 353473 170828 110064917
Toxicity to various agents 309.72 10.28 672 352882 479883 109755862
Coronary artery bypass 308.08 10.28 209 353345 5833 110229912
Cardiac failure 303.71 10.28 1297 352257 186329 110049416
Post procedural haemorrhage 298.71 10.28 305 353249 15207 110220538
Coronary artery restenosis 297.79 10.28 120 353434 1072 110234673
Swelling 293.14 10.28 417 353137 350624 109885121
Pain 290.58 10.28 1826 351728 953129 109282616
Drug abuse 287.07 10.28 104 353450 177307 110058438
Arthralgia 286.07 10.28 1401 352153 778231 109457514
Facet joint syndrome 284.06 10.28 5 353549 96823 110138922
Infection 282.40 10.28 451 353103 361749 109873996
Pyrexia 277.16 10.28 1710 351844 896555 109339190
Lower respiratory tract infection 274.97 10.28 224 353330 242882 109992863
Hypersensitivity 272.82 10.28 550 353004 403448 109832297
Lip dry 272.03 10.28 11 353543 100072 110135673
Weight increased 270.20 10.28 587 352967 419057 109816688
Discomfort 269.89 10.28 177 353377 214530 110021215
Carotid artery stenosis 269.09 10.28 229 353325 9034 110226711
Musculoskeletal stiffness 268.41 10.28 299 353255 279523 109956222
Gastritis erosive 268.33 10.28 256 353298 11744 110224001
Intentional product use issue 267.48 10.28 239 353315 247667 109988078
Drug hypersensitivity 266.86 10.28 667 352887 453423 109782322
Wound 266.42 10.28 215 353339 234222 110001523
Product use issue 264.47 10.28 366 353188 311329 109924416
Multiple injuries 253.84 10.28 153 353401 3461 110232284
Cerebral haematoma 253.33 10.28 225 353329 9407 110226338
Atrial fibrillation 252.24 10.28 1421 352133 228221 110007524
Ill-defined disorder 252.00 10.28 93 353461 156760 110078985
Thrombotic thrombocytopenic purpura 249.01 10.28 196 353358 6915 110228830
Bursitis 247.32 10.28 56 353498 129862 110105883
Cardiac disorder 246.22 10.28 665 352889 75615 110160130
Hyperkalaemia 245.97 10.28 972 352582 134824 110100921
Hemiparesis 239.74 10.28 471 353083 43432 110192313
Duodenal ulcer 236.75 10.28 302 353252 19212 110216533
Peripheral arterial occlusive disease 234.62 10.28 212 353342 9068 110226677
Bradycardia 228.10 10.28 1044 352510 154473 110081272
Spinal epidural haematoma 224.77 10.28 110 353444 1615 110234130
Ecchymosis 224.17 10.28 277 353277 17061 110218684
International normalised ratio increased 223.72 10.28 698 352856 86074 110149671
Retroperitoneal haematoma 223.38 10.28 173 353381 5958 110229787
Impaired healing 212.96 10.28 189 353365 196528 110039217
Gastric ulcer 212.31 10.28 423 353131 39404 110196341
Retroperitoneal haemorrhage 212.01 10.28 167 353387 5898 110229847
Diverticulum intestinal haemorrhagic 206.10 10.28 149 353405 4614 110231131
Duodenal ulcer haemorrhage 205.94 10.28 185 353369 7852 110227893
Haemorrhagic stroke 204.08 10.28 236 353318 13553 110222192
Gastrointestinal disorder 202.30 10.28 287 353267 241665 109994080
Abdominal discomfort 201.91 10.28 618 352936 393240 109842505
Intraventricular haemorrhage 197.62 10.28 154 353400 5353 110230392
Asthma 196.56 10.28 310 353244 249981 109985764
Live birth 194.54 10.28 6 353548 69478 110166267
Ischaemic cardiomyopathy 192.74 10.28 178 353376 7833 110227912
Wheezing 191.21 10.28 326 353228 254904 109980841
Mitral valve incompetence 191.06 10.28 365 353189 32964 110202781
Product administration error 186.18 10.28 385 353169 36832 110198913
Dizziness 182.48 10.28 3190 350364 695003 109540742
Subdural haemorrhage 182.11 10.28 158 353396 6400 110229345
Migraine 178.58 10.28 171 353383 171481 110064264
Joint range of motion decreased 176.77 10.28 84 353470 121748 110113997
Arteriosclerosis 176.21 10.28 298 353256 24469 110211276
Insulin autoimmune syndrome 176.11 10.28 72 353482 670 110235075
Sleep disorder 173.74 10.28 228 353326 198416 110037329
Contraindicated product administered 171.78 10.28 333 353221 247934 109987811
Wound infection 171.21 10.28 48 353506 96417 110139328
Rash 168.45 10.28 1745 351809 819219 109416526
Obesity 167.79 10.28 76 353478 113275 110122470
Blister 167.05 10.28 294 353260 227082 110008663
Type 2 diabetes mellitus 167.03 10.28 192 353362 177040 110058705
Blood cholesterol increased 164.80 10.28 209 353345 184576 110051169
Grip strength decreased 164.20 10.28 29 353525 80145 110155600
Post procedural haematoma 163.17 10.28 103 353451 2536 110233209
Abdominal wall haematoma 161.56 10.28 139 353415 5566 110230179
Cardiac tamponade 161.47 10.28 190 353364 11117 110224628
Disease progression 160.57 10.28 337 353217 243697 109992048
Renal failure 160.06 10.28 1256 352298 225318 110010427
Myalgia 159.44 10.28 1237 352317 221144 110014601
C-reactive protein increased 158.08 10.28 284 353270 217635 110018110
Inflammation 157.79 10.28 233 353321 193005 110042740
Myelosuppression 156.54 10.28 53 353501 94287 110141458
Muscle haemorrhage 156.36 10.28 148 353406 6721 110229024
Mobility decreased 156.10 10.28 328 353226 237094 109998651
Intermittent claudication 153.84 10.28 113 353441 3588 110232157
Pallor 152.78 10.28 462 353092 56005 110179740
Cardiac arrest 150.35 10.28 1111 352443 195642 110040103
Extradural haematoma 149.46 10.28 107 353447 3262 110232483
Night sweats 148.29 10.28 126 353428 133857 110101888
Loss of personal independence in daily activities 146.32 10.28 158 353396 149862 110085883
Pericardial haemorrhage 145.49 10.28 126 353428 5091 110230654
Liver injury 144.95 10.28 160 353394 150253 110085492
Gastritis 144.01 10.28 438 353116 53261 110182484
Completed suicide 143.81 10.28 354 353200 242027 109993718
Presyncope 143.74 10.28 412 353142 48475 110187270
Dyspnoea 143.72 10.28 4588 348966 1102284 109133461
Blood creatine phosphokinase increased 143.69 10.28 537 353017 72540 110163205
Lower limb fracture 142.35 10.28 33 353521 75315 110160430
Pregnancy 140.87 10.28 5 353549 51062 110184683
Asthenia 140.83 10.28 3033 350521 685966 109549779
Gastric ulcer haemorrhage 138.18 10.28 166 353388 9928 110225817
Occult blood positive 137.23 10.28 143 353411 7302 110228443
Hip arthroplasty 136.82 10.28 11 353543 55802 110179943
Arterial haemorrhage 135.31 10.28 106 353448 3713 110232032
Condition aggravated 131.68 10.28 1610 351944 733226 109502519
Peripheral venous disease 131.54 10.28 52 353502 84065 110151680
Respiratory tract haemorrhage 130.55 10.28 81 353473 1933 110233812
Iron deficiency anaemia 130.05 10.28 302 353252 31257 110204488
Osteoarthritis 127.13 10.28 244 353310 182379 110053366
Angioplasty 127.08 10.28 79 353475 1892 110233853
Adjustment disorder with depressed mood 125.79 10.28 3 353551 43880 110191865
Lactic acidosis 125.75 10.28 609 352945 92202 110143543
Dislocation of vertebra 125.28 10.28 3 353551 43718 110192027
Autoimmune disorder 125.07 10.28 28 353526 65455 110170290
Sciatica 124.68 10.28 70 353484 92329 110143416
Injection site reaction 123.80 10.28 65 353489 89005 110146740
Oesophageal intramural haematoma 122.54 10.28 39 353515 158 110235587
Splenic rupture 122.17 10.28 86 353468 2551 110233194
Coronary angioplasty 121.13 10.28 47 353507 376 110235369
COVID-19 120.23 10.28 392 353162 244668 109991077
Peripheral swelling 119.13 10.28 779 352775 403255 109832490
Headache 118.98 10.28 2045 351509 880332 109355413
Product prescribing error 117.90 10.28 397 353157 50934 110184811
Haemorrhagic transformation stroke 117.90 10.28 89 353465 2948 110232797
Onychomadesis 117.75 10.28 7 353547 45656 110190089
Cytokine release syndrome 117.51 10.28 39 353515 70267 110165478
Hypoaesthesia 115.85 10.28 563 352991 313660 109922085
Troponin increased 115.24 10.28 278 353276 29488 110206257
Malignant neoplasm progression 114.86 10.28 241 353313 174326 110061419
Chronic kidney disease 114.67 10.28 516 353038 75775 110159970
Electrocardiogram ST segment elevation 114.66 10.28 144 353410 9016 110226729
Loss of consciousness 114.65 10.28 1043 352511 195263 110040482
Knee arthroplasty 113.99 10.28 33 353521 64915 110170830
Pulmonary alveolar haemorrhage 113.43 10.28 219 353335 19931 110215814
Ventricular tachycardia 113.30 10.28 385 353169 49624 110186121
Arterial stenosis 112.32 10.28 68 353486 1551 110234194
Liver function test increased 111.21 10.28 73 353481 88475 110147270
Microcytic anaemia 110.28 10.28 117 353437 6101 110229644
Insomnia 109.99 10.28 688 352866 359902 109875843
Circulatory collapse 109.09 10.28 344 353210 42649 110193096
Dry mouth 107.97 10.28 306 353248 199642 110036103
Peripheral vascular disorder 107.64 10.28 135 353419 8441 110227304
Coronary artery perforation 107.47 10.28 30 353524 67 110235678
Peripheral artery stenosis 107.37 10.28 62 353492 1292 110234453
Coeliac disease 107.31 10.28 8 353546 43179 110192566
Procedural haemorrhage 106.84 10.28 108 353446 5319 110230426
Aphasia 104.92 10.28 420 353134 58577 110177168
Red blood cell sedimentation rate increased 104.68 10.28 60 353494 78242 110157503
Haemorrhage subcutaneous 103.19 10.28 107 353447 5432 110230313
Hyponatraemia 103.05 10.28 1107 352447 216546 110019199
Heparin-induced thrombocytopenia 102.72 10.28 153 353401 11271 110224474
Peripheral ischaemia 102.16 10.28 150 353404 10908 110224837
Ejection fraction decreased 101.81 10.28 325 353229 40555 110195190
Spinal cord haemorrhage 101.49 10.28 46 353508 562 110235183
Cardiogenic shock 100.22 10.28 406 353148 56932 110178813
Blood pressure decreased 99.63 10.28 670 352884 114421 110121324
Nail disorder 98.84 10.28 31 353523 57904 110177841
Haemarthrosis 97.83 10.28 119 353435 7210 110228535
Mallory-Weiss syndrome 97.70 10.28 81 353473 3080 110232665
Arteriosclerosis coronary artery 97.68 10.28 235 353319 24883 110210862
Intestinal haemorrhage 97.67 10.28 119 353435 7222 110228523
Duodenitis 97.16 10.28 133 353421 9063 110226682
Vascular stent occlusion 96.66 10.28 36 353518 254 110235491
Prescribed overdose 94.92 10.28 84 353470 87497 110148248
Neutropenia 94.58 10.28 755 352799 373865 109861880
Road traffic accident 94.15 10.28 123 353431 107275 110128470
Vascular graft 93.14 10.28 67 353487 2058 110233687
Percutaneous coronary intervention 93.02 10.28 40 353514 427 110235318
Head injury 92.94 10.28 326 353228 42691 110193054
Gingival bleeding 92.00 10.28 199 353355 19640 110216105
Petechiae 90.51 10.28 218 353336 23099 110212646
Adverse drug reaction 90.39 10.28 123 353431 105436 110130309
Retinitis 89.75 10.28 3 353551 32324 110203421
Dermatitis exfoliative 89.44 10.28 143 353411 11204 110224541
Arterial occlusive disease 89.40 10.28 169 353385 15139 110220606
Tricuspid valve incompetence 89.26 10.28 220 353334 23653 110212092
Abortion spontaneous 89.18 10.28 5 353549 34277 110201468
Injection site pain 89.07 10.28 282 353272 177640 110058105
Conjunctival haemorrhage 89.03 10.28 108 353446 6525 110229220
Acquired haemophilia 88.87 10.28 71 353483 2560 110233185
Haemothorax 88.76 10.28 111 353443 6920 110228825
Embolic stroke 88.70 10.28 124 353430 8619 110227126
Hyphaema 88.61 10.28 51 353503 1056 110234689
Gait inability 88.27 10.28 190 353364 136186 110099559
Foot deformity 88.13 10.28 23 353531 48457 110187288
Coronary artery dissection 88.08 10.28 53 353501 1195 110234550
Adverse event 88.02 10.28 132 353422 108677 110127068
Ventricular hypokinesia 87.95 10.28 141 353413 11073 110224672
Hiatus hernia 87.39 10.28 239 353315 27367 110208378
Haemorrhagic cholecystitis 87.05 10.28 29 353525 140 110235605
Bleeding time prolonged 86.01 10.28 53 353501 1249 110234496
Therapy non-responder 84.72 10.28 241 353313 157066 110078679
White blood cell count decreased 84.52 10.28 411 353143 228979 110006766
Frequent bowel movements 84.18 10.28 63 353491 71327 110164418
Small intestinal haemorrhage 83.87 10.28 88 353466 4530 110231215
Dyspnoea exertional 83.70 10.28 595 352959 103465 110132280
Osteoporosis 83.63 10.28 93 353461 87059 110148686
Haemobilia 83.17 10.28 41 353513 612 110235133
Occult blood 82.46 10.28 59 353495 1797 110233948
Arthritis 82.22 10.28 268 353286 167318 110068427
Lacunar infarction 82.18 10.28 101 353453 6185 110229560
Kounis syndrome 82.02 10.28 98 353456 5827 110229918
Gastrointestinal tract mucosal pigmentation 81.87 10.28 51 353503 1226 110234519
Device occlusion 81.79 10.28 162 353392 15023 110220722
Cardiac aneurysm 81.06 10.28 57 353497 1688 110234057
Arrhythmia 80.61 10.28 437 353117 69138 110166607
Cardiovascular disorder 80.13 10.28 205 353349 22555 110213190
Haematoma muscle 79.80 10.28 81 353473 4009 110231736
Carotid arteriosclerosis 79.57 10.28 71 353483 2986 110232759
Onychomycosis 78.76 10.28 14 353540 38517 110197228
Injection site erythema 78.38 10.28 112 353442 94064 110141681
Electrocardiogram Q wave abnormal 78.11 10.28 41 353513 703 110235042
Immunodeficiency 77.48 10.28 15 353539 38823 110196922
Brain herniation 77.26 10.28 117 353437 8746 110226999
Colitis ulcerative 77.07 10.28 80 353474 77283 110158462
Peripheral artery occlusion 76.67 10.28 68 353486 2837 110232908
Cardiac failure chronic 76.39 10.28 149 353405 13662 110222083
Drug ineffective for unapproved indication 76.37 10.28 132 353422 102706 110133039
Vascular graft occlusion 75.94 10.28 40 353514 691 110235054
Fatigue 75.83 10.28 3149 350405 1212809 109022936
Cerebellar haemorrhage 75.45 10.28 71 353483 3200 110232545
Dysarthria 75.39 10.28 494 353060 83627 110152118
Orthostatic hypotension 75.33 10.28 414 353140 65835 110169910
Gastrointestinal vascular malformation haemorrhagic 75.31 10.28 44 353510 938 110234807
Spontaneous haematoma 75.09 10.28 57 353497 1904 110233841
Liver disorder 75.08 10.28 220 353334 142023 110093722
Blood creatine phosphokinase MB increased 74.73 10.28 67 353487 2836 110232909
Aortic aneurysm 74.24 10.28 122 353432 9782 110225963
Hepatojugular reflux 72.91 10.28 39 353515 696 110235049
Hemiplegia 72.87 10.28 198 353356 22584 110213161
Psoriasis 72.82 10.28 218 353336 139775 110095970
Ischaemia 72.33 10.28 115 353439 8968 110226777
Thrombosis 72.12 10.28 594 352960 108068 110127677
Renal impairment 72.09 10.28 920 352634 187525 110048220
Myocardial rupture 71.49 10.28 29 353525 264 110235481
Internal haemorrhage 71.40 10.28 121 353433 9950 110225795
Breast cancer stage II 71.19 10.28 4 353550 27371 110208374
Sleep disorder due to a general medical condition 71.00 10.28 39 353515 52073 110183672
Urticaria 70.93 10.28 664 352890 318193 109917552
Memory impairment 70.74 10.28 356 353198 196588 110039157
Cerebral mass effect 70.66 10.28 60 353494 2359 110233386
Intentional overdose 70.62 10.28 204 353350 132297 110103448
Drug dependence 70.26 10.28 36 353518 49984 110185761
Intra-abdominal haematoma 70.01 10.28 70 353484 3402 110232343
Finger deformity 69.91 10.28 11 353543 33081 110202664
Intracardiac thrombus 69.90 10.28 77 353477 4191 110231554
Pemphigoid 69.89 10.28 178 353376 19529 110216216
Inappropriate schedule of product administration 69.83 10.28 374 353180 203263 110032482
Mediastinal haematoma 69.80 10.28 27 353527 214 110235531
Angiopathy 68.79 10.28 110 353444 8620 110227125
Ventricular fibrillation 68.63 10.28 288 353266 41025 110194720
Traumatic haematoma 68.58 10.28 59 353495 2362 110233383
Cytomegalovirus infection 68.21 10.28 45 353509 54399 110181346
Blood glucose increased 67.93 10.28 685 352869 131811 110103934
Aortic valve incompetence 67.59 10.28 124 353430 10857 110224888
Coagulation time prolonged 66.68 10.28 63 353491 2854 110232891
Helicobacter gastritis 66.60 10.28 60 353494 2556 110233189
Vitreous haemorrhage 66.58 10.28 78 353476 4542 110231203
Drug tolerance decreased 65.94 10.28 6 353548 27534 110208211
Device expulsion 65.87 10.28 10 353544 30881 110204864
Atrioventricular block 65.73 10.28 158 353396 16719 110219026
Musculoskeletal pain 65.64 10.28 331 353223 182692 110053053
Diverticulum intestinal 65.51 10.28 127 353427 11592 110224153
Taste disorder 64.70 10.28 68 353486 65319 110170426
Hypercholesterolaemia 64.39 10.28 120 353434 90717 110145028
Neoplasm progression 64.12 10.28 67 353487 64528 110171217
Chest discomfort 64.08 10.28 843 352711 173005 110062740
Diverticulum 63.34 10.28 148 353406 15378 110220367
Oesophagitis 63.23 10.28 219 353335 28496 110207249
Eosinophilia 63.18 10.28 358 353196 57578 110178167
Angioedema 62.46 10.28 533 353021 97967 110137778
Gastrointestinal polyp haemorrhage 62.39 10.28 36 353518 749 110234996
Joint stiffness 62.09 10.28 74 353480 67169 110168576
Puncture site haemorrhage 62.02 10.28 35 353519 697 110235048
Laryngitis 61.88 10.28 29 353525 42382 110193363
Upper respiratory tract infection 61.69 10.28 214 353340 131114 110104631
Pulmonary fibrosis 61.30 10.28 148 353406 101894 110133851
Ear infection 61.23 10.28 66 353488 62666 110173079
Sedation 60.87 10.28 80 353474 69603 110166142
Lung disorder 60.45 10.28 333 353221 179714 110056031
Therapeutic response decreased 60.34 10.28 137 353417 96362 110139383
Dyspnoea at rest 60.13 10.28 101 353453 8245 110227500
Mouth haemorrhage 59.94 10.28 133 353421 13355 110222390
Aortic valve stenosis 59.91 10.28 87 353467 6263 110229482
Posterior reversible encephalopathy syndrome 59.79 10.28 17 353537 33844 110201901
Poisoning deliberate 59.78 10.28 7 353547 26324 110209421
Arterial restenosis 59.43 10.28 17 353537 43 110235702
Stenosis 59.33 10.28 63 353491 3288 110232457
Large intestinal haemorrhage 59.13 10.28 61 353493 3078 110232667
Cerebral ischaemia 59.11 10.28 124 353430 11980 110223765
Gastrointestinal angiodysplasia 58.81 10.28 41 353513 1197 110234548
Acute pulmonary oedema 58.71 10.28 152 353402 16844 110218901
Unmasking of previously unidentified disease 58.16 10.28 58 353496 2810 110232935
Cerebral hyperperfusion syndrome 58.04 10.28 20 353534 109 110235636
Systolic dysfunction 57.82 10.28 71 353483 4344 110231401
Angiocardiogram 57.56 10.28 25 353529 274 110235471
Hypovolaemic shock 57.31 10.28 137 353417 14446 110221299
Wound haemorrhage 56.95 10.28 73 353481 4665 110231080
Pulmonary haemorrhage 56.67 10.28 147 353407 16309 110219436
Spinal subarachnoid haemorrhage 56.60 10.28 17 353537 54 110235691
Coagulation time abnormal 56.59 10.28 22 353532 177 110235568
Infective exacerbation of chronic obstructive airways disease 56.53 10.28 60 353494 3130 110232615
N-terminal prohormone brain natriuretic peptide increased 56.50 10.28 83 353471 6038 110229707
Degenerative mitral valve disease 55.56 10.28 25 353529 300 110235445
Eosinophilic bronchitis 55.08 10.28 30 353524 556 110235189
Spontaneous haemorrhage 55.05 10.28 39 353515 1169 110234576
Urinary retention 54.62 10.28 396 353158 69287 110166458
Ocular retrobulbar haemorrhage 54.56 10.28 21 353533 164 110235581
Jaundice 53.77 10.28 349 353205 58887 110176858
Renal injury 53.35 10.28 156 353398 18557 110217188
Gastritis haemorrhagic 53.27 10.28 58 353496 3115 110232630
Facial paralysis 52.73 10.28 184 353370 24030 110211715
Pharyngeal haematoma 52.43 10.28 20 353534 152 110235593
Diabetes mellitus inadequate control 52.16 10.28 211 353343 29564 110206181
Atrioventricular block complete 52.16 10.28 162 353392 19920 110215825
Oedema peripheral 52.11 10.28 1398 352156 327262 109908483
Catheter site haematoma 51.98 10.28 26 353528 401 110235344
Intentional product misuse 51.96 10.28 233 353321 132671 110103074
Dehydration 51.74 10.28 1214 352340 278297 109957448
Suicide attempt 51.64 10.28 164 353390 103230 110132515
Pulmonary haematoma 51.64 10.28 19 353535 129 110235616
Therapy partial responder 51.56 10.28 27 353527 37034 110198711
Coronary artery reocclusion 51.39 10.28 19 353535 131 110235614
Platelet function test abnormal 51.22 10.28 20 353534 163 110235582
Infarction 50.90 10.28 73 353481 5196 110230549
Peptic ulcer 50.69 10.28 89 353465 7530 110228215
Inferior vena cava dilatation 50.62 10.28 34 353520 933 110234812
Bundle branch block left 50.56 10.28 121 353433 12767 110222978
Subcutaneous haematoma 50.11 10.28 55 353499 2981 110232764
Neuropathy peripheral 50.10 10.28 351 353203 178926 110056819
Neurotoxicity 50.08 10.28 37 353517 42170 110193575
Epilepsy 50.02 10.28 159 353395 100050 110135695
Large intestine polyp 49.98 10.28 133 353421 14984 110220761
Aortic arteriosclerosis 49.90 10.28 109 353445 10829 110224916
Haemorrhage urinary tract 49.87 10.28 54 353500 2882 110232863
Haemorrhagic arteriovenous malformation 49.78 10.28 28 353526 554 110235191
Subarachnoid haematoma 49.75 10.28 23 353531 295 110235450
Oropharyngeal pain 49.45 10.28 243 353311 135033 110100712
Purpura 49.42 10.28 181 353373 24207 110211538
Normal newborn 49.27 10.28 6 353548 21890 110213855
Tachyarrhythmia 49.24 10.28 92 353462 8169 110227576
Haemorrhagic ascites 49.14 10.28 23 353531 304 110235441
Mucosal inflammation 49.07 10.28 151 353403 95990 110139755
Neutrophil count decreased 48.51 10.28 210 353344 120731 110115014
Left ventricular dysfunction 48.15 10.28 175 353379 23318 110212427
Lupus-like syndrome 48.09 10.28 36 353518 40756 110194989
Mesenteric haematoma 48.07 10.28 16 353538 77 110235668
Ischaemic cerebral infarction 48 10.28 53 353501 2892 110232853
Orbital compartment syndrome 47.98 10.28 17 353537 102 110235643
Hepatitis cholestatic 47.77 10.28 144 353410 17422 110218323
Lymphocyte count decreased 47.70 10.28 68 353486 57175 110178570
Electrocardiogram ST segment depression 47.47 10.28 72 353482 5389 110230356
Basal ganglia haemorrhage 47.47 10.28 43 353511 1845 110233900
Muscle spasticity 47.32 10.28 28 353526 35887 110199858
Influenza 46.80 10.28 332 353222 168769 110066976
Intracranial haematoma 46.24 10.28 33 353521 1001 110234744
Nausea 46.20 10.28 3365 350189 1232325 109003420
Incorrect route of product administration 45.96 10.28 84 353470 63977 110171768
Drug use disorder 45.91 10.28 3 353551 18071 110217674
Atheroembolism 45.80 10.28 23 353531 358 110235387
Product substitution issue 45.76 10.28 170 353384 22891 110212854
Product dose omission issue 45.74 10.28 738 352816 321044 109914701
Renal haemorrhage 45.65 10.28 48 353506 2477 110233268
Lymphatic fistula 45.56 10.28 38 353516 1457 110234288
Splenic haematoma 45.44 10.28 22 353532 315 110235430
Abnormal loss of weight 45.42 10.28 101 353453 10156 110225589
Post procedural complication 45.19 10.28 187 353367 26471 110209274
Muscle rupture 44.87 10.28 63 353491 4397 110231348
Atrial thrombosis 44.63 10.28 62 353492 4284 110231461
Eye haemorrhage 44.54 10.28 109 353445 11665 110224080
Incision site haemorrhage 44.46 10.28 33 353521 1065 110234680
Chronic obstructive pulmonary disease 44.34 10.28 539 353015 108619 110127126
Kidney rupture 44.08 10.28 20 353534 245 110235500
Back injury 43.93 10.28 52 353502 47347 110188398
Urogenital haemorrhage 43.65 10.28 31 353523 933 110234812
Ear pain 43.60 10.28 64 353490 53162 110182583
Chronic sinusitis 43.55 10.28 13 353541 25071 110210674
Paraesthesia 43.47 10.28 622 352932 275899 109959846
Hyperlipidaemia 43.45 10.28 228 353326 35620 110200125
Hypomagnesaemia 43.31 10.28 336 353218 60034 110175711
Leriche syndrome 43.28 10.28 17 353537 141 110235604
Femoral hernia incarcerated 43.20 10.28 37 353517 1472 110234273
Pituitary haemorrhage 43.11 10.28 21 353533 305 110235440
Impaired quality of life 43.06 10.28 21 353533 29996 110205749
Disorientation 43.02 10.28 379 353175 70292 110165453
Aortic dissection 42.83 10.28 65 353489 4868 110230877
Injury 42.52 10.28 362 353192 176903 110058842
Haematotoxicity 42.36 10.28 8 353546 21074 110214671
Fractional exhaled nitric oxide increased 42.34 10.28 28 353526 748 110234997
Myopathy 42.24 10.28 175 353379 24785 110210960
Chromaturia 42.19 10.28 196 353358 29164 110206581
Carotid artery occlusion 42.14 10.28 94 353460 9471 110226274
Skin candida 41.63 10.28 44 353510 2284 110233461
Haemodynamic instability 41.54 10.28 164 353390 22724 110213021
Myoglobin blood increased 41.42 10.28 59 353495 4173 110231572
Haemophagocytic lymphohistiocytosis 41.02 10.28 25 353529 31534 110204211
Pancreatic steatosis 40.98 10.28 39 353515 1783 110233962
Acute myeloid leukaemia 40.75 10.28 37 353517 38073 110197672
Overdose 40.69 10.28 515 353039 233279 110002466
Injection site pruritus 40.66 10.28 63 353491 51195 110184550
Herpes zoster 40.59 10.28 193 353361 108186 110127559
Toxic skin eruption 40.51 10.28 185 353369 27330 110208415
Intentional self-injury 40.43 10.28 36 353518 37393 110198352
Gynaecomastia 40.40 10.28 92 353462 9398 110226347
Hydrocephalus 40.27 10.28 97 353457 10278 110225467
Cardiac ventricular thrombosis 40.23 10.28 50 353504 3097 110232648
Rheumatoid nodule 40.15 10.28 8 353546 20288 110215457
Orbital haematoma 39.90 10.28 11 353543 23 110235722
Haemoperitoneum 39.88 10.28 66 353488 5322 110230423
Traumatic intracranial haemorrhage 39.85 10.28 35 353519 1441 110234304
Cardiac operation 39.85 10.28 70 353484 5925 110229820
Anhedonia 39.65 10.28 124 353430 15304 110220441
Product monitoring error 39.64 10.28 88 353466 8839 110226906
Skin flap necrosis 39.58 10.28 11 353543 24 110235721
Pulmonary oedema 39.57 10.28 494 353060 100165 110135580
Page kidney 39.49 10.28 13 353541 60 110235685
Anxiety 39.46 10.28 822 352732 344256 109891489
Pathogen resistance 39.38 10.28 5 353549 17667 110218078
Angiodysplasia 39.33 10.28 35 353519 1467 110234278
Compartment syndrome 39.27 10.28 69 353485 5841 110229904
Lip swelling 39.17 10.28 287 353267 50380 110185365
Brain stem haemorrhage 39.02 10.28 38 353516 1788 110233957
Neuroleptic malignant syndrome 38.95 10.28 31 353523 34028 110201717
Sinus bradycardia 38.87 10.28 192 353362 29291 110206454
Bladder tamponade 38.82 10.28 26 353528 710 110235035
Vessel puncture site haematoma 38.72 10.28 18 353536 234 110235511
Multiple sclerosis relapse 38.67 10.28 63 353491 50177 110185568
Lichen planopilaris 38.66 10.28 16 353538 154 110235591
Red blood cell sedimentation rate abnormal 38.56 10.28 15 353539 24494 110211251
Pulmonary vascular disorder 38.54 10.28 30 353524 1041 110234704
Implant site haematoma 38.53 10.28 17 353537 194 110235551
Thalamus haemorrhage 38.51 10.28 39 353515 1925 110233820
Schizophrenia 38.46 10.28 11 353543 21815 110213930
Arterial stent insertion 38.31 10.28 14 353540 93 110235652
Pulmonary valve disease 38.31 10.28 20 353534 339 110235406
Blood pressure inadequately controlled 38.21 10.28 79 353475 7554 110228191
Blood creatinine increased 38.13 10.28 808 352746 182081 110053664
Eructation 38.00 10.28 115 353439 13942 110221803
Urinary bladder haemorrhage 37.96 10.28 46 353508 2776 110232969
Haemorrhagic diathesis 37.93 10.28 78 353476 7430 110228315
Exercise tolerance decreased 37.72 10.28 104 353450 11963 110223782
Acne 37.72 10.28 31 353523 33489 110202256
Fat embolism 37.70 10.28 23 353531 532 110235213
Injection site swelling 37.60 10.28 89 353465 61701 110174044
Pneumonia 37.10 10.28 2361 351193 874353 109361392
Mucosal haemorrhage 37.04 10.28 47 353507 2973 110232772
Pericardial effusion 37.00 10.28 311 353243 56906 110178839
Bronchopulmonary aspergillosis 36.98 10.28 25 353529 29838 110205907
Erosive duodenitis 36.94 10.28 41 353513 2250 110233495
Cerebrovascular disorder 36.71 10.28 52 353502 3659 110232086
Haemorrhage coronary artery 36.57 10.28 10 353544 20 110235725
Left ventricular hypertrophy 36.42 10.28 109 353445 13135 110222610
Lipoprotein (a) increased 36.30 10.28 14 353540 110 110235635
No adverse event 36.26 10.28 118 353436 73721 110162024
Peptic ulcer haemorrhage 36.13 10.28 30 353524 1143 110234602
Labile hypertension 36.09 10.28 23 353531 576 110235169
Anaemia macrocytic 35.88 10.28 75 353479 7228 110228517
Cardiac death 35.69 10.28 35 353519 1661 110234084
Bundle branch block right 35.56 10.28 103 353451 12188 110223557
Full blood count abnormal 35.51 10.28 79 353475 55973 110179772
Increased tendency to bruise 35.44 10.28 100 353454 11658 110224087
Serotonin syndrome 35.36 10.28 86 353468 59067 110176678
Suicidal ideation 35.34 10.28 167 353387 93770 110141975
Oedema 35.25 10.28 466 353088 209510 110026235
Mesenteric artery thrombosis 34.96 10.28 27 353527 926 110234819
Hallucination 34.95 10.28 486 353068 100946 110134799
Infusion site reaction 34.91 10.28 7 353547 17675 110218070
Cerebellar haematoma 34.89 10.28 23 353531 611 110235134
Erosive oesophagitis 34.89 10.28 46 353508 3023 110232722
Oesophageal ulcer 34.79 10.28 78 353476 7886 110227859
Cardiac failure acute 34.79 10.28 161 353393 23917 110211828
Nasal congestion 34.52 10.28 179 353375 98103 110137642
Dilatation ventricular 34.40 10.28 53 353501 4022 110231723
Haemorrhagic infarction 34.40 10.28 26 353528 863 110234882
Extravasation blood 34.19 10.28 21 353533 492 110235253
Coagulopathy 34.10 10.28 236 353318 40675 110195070
Transplant rejection 34.03 10.28 18 353536 24549 110211196
Haemangioma of spleen 33.96 10.28 9 353545 15 110235730
Hepatic cirrhosis 33.96 10.28 107 353447 67519 110168226
Haemorrhoidal haemorrhage 33.95 10.28 78 353476 8015 110227730
Amaurosis 33.83 10.28 33 353521 1556 110234189
Adverse reaction 33.76 10.28 27 353527 29567 110206178
Cholestasis 33.75 10.28 335 353219 64183 110171562
Diarrhoea 33.73 10.28 3161 350393 1136344 109099401
Normocytic anaemia 33.64 10.28 68 353486 6399 110229346
Renal artery stenosis 33.64 10.28 50 353504 3676 110232069
Vaginal discharge 33.51 10.28 8 353546 17900 110217845
Illness 33.37 10.28 142 353412 82029 110153716
Catheterisation cardiac 33.28 10.28 66 353488 6125 110229620
Exostosis 33.20 10.28 60 353494 45896 110189849
Chronic gastritis 33.18 10.28 61 353493 5350 110230395
Potentiating drug interaction 33.13 10.28 97 353457 11546 110224199
Peripheral artery bypass 33.08 10.28 13 353541 108 110235637
Haematocrit decreased 33.00 10.28 340 353214 65777 110169968
Endothelial dysfunction 32.98 10.28 18 353536 335 110235410
Immune reconstitution inflammatory syndrome 32.94 10.28 6 353548 16220 110219525
Oesophageal spasm 32.82 10.28 49 353505 3617 110232128
Carotid artery disease 32.82 10.28 38 353516 2185 110233560
Brain stem stroke 32.81 10.28 24 353530 757 110234988
Colonic haematoma 32.80 10.28 12 353542 80 110235665
Cytomegalovirus infection reactivation 32.75 10.28 9 353545 18324 110217421
Retinal artery occlusion 32.74 10.28 53 353501 4196 110231549
Sudden cardiac death 32.63 10.28 62 353492 5575 110230170
Cytopenia 32.49 10.28 29 353525 30087 110205658
Euglycaemic diabetic ketoacidosis 32.28 10.28 96 353458 11527 110224218
Pericardial disease 32.16 10.28 23 353531 700 110235045
Myocardial necrosis marker increased 32.11 10.28 50 353504 3830 110231915
Spinal cord haematoma 32.10 10.28 17 353537 297 110235448
Wound infection pseudomonas 31.94 10.28 39 353515 2372 110233373
Spinal cord compression 31.92 10.28 73 353481 7479 110228266
Cerebral artery stenosis 31.76 10.28 25 353529 882 110234863
Coronary ostial stenosis 31.71 10.28 14 353540 160 110235585
Laryngeal haemorrhage 31.62 10.28 11 353543 62 110235683
Dystonia 31.43 10.28 22 353532 25783 110209962
Tongue haemorrhage 31.39 10.28 28 353526 1177 110234568
Multiple-drug resistance 31.38 10.28 3 353551 13232 110222513
Quadriparesis 31.33 10.28 55 353499 4652 110231093
Gastrointestinal ulcer 31.29 10.28 52 353502 4208 110231537
Cytomegalovirus viraemia 31.22 10.28 9 353545 17755 110217990
Intracranial aneurysm 31.13 10.28 57 353497 4983 110230762
Rales 31.13 10.28 159 353395 24580 110211165
Cardiac discomfort 31.05 10.28 30 353524 1398 110234347
Urethral haemorrhage 31.03 10.28 20 353534 511 110235234
Cold sweat 30.87 10.28 146 353408 21885 110213860
Physical examination abnormal 30.86 10.28 20 353534 516 110235229
Seroma 30.82 10.28 45 353509 3256 110232489
Ventricular hypertrophy 30.78 10.28 69 353485 6976 110228769
Orthopnoea 30.58 10.28 91 353463 10930 110224815
Bladder sphincter atony 30.54 10.28 15 353539 222 110235523
Product quality issue 30.52 10.28 135 353419 77164 110158581
Helicobacter test positive 30.51 10.28 29 353525 1324 110234421
Lacunar stroke 30.35 10.28 20 353534 531 110235214
Oesophageal mucosal dissection 30.35 10.28 9 353545 27 110235718
Capillary fragility test 30.35 10.28 9 353545 27 110235718
Fungal infection 30.26 10.28 74 353480 50732 110185013
Thrombotic cerebral infarction 30.23 10.28 23 353531 771 110234974
Hypertensive crisis 30.22 10.28 156 353398 24216 110211529
Temperature regulation disorder 30.16 10.28 3 353551 12823 110222922
Premature delivery 30.14 10.28 32 353522 30600 110205145
Venoocclusive liver disease 30.07 10.28 6 353548 15201 110220544
Groin pain 30.01 10.28 113 353441 15315 110220430
Intra-abdominal haemorrhage 29.99 10.28 58 353496 5284 110230461
Fear 29.84 10.28 150 353404 23043 110212702
Feeling hot 29.75 10.28 170 353384 90936 110144809
Blood cholesterol 29.74 10.28 24 353530 878 110234867
Spinal subdural haematoma 29.73 10.28 15 353539 236 110235509
Aspergillus infection 29.69 10.28 23 353531 25593 110210152
Ventricular arrhythmia 29.63 10.28 85 353469 10002 110225743
Coma scale abnormal 29.59 10.28 83 353471 9643 110226102
Mitral valve disease 29.55 10.28 45 353509 3380 110232365
Low density lipoprotein increased 29.53 10.28 88 353466 10578 110225167
Brain contusion 29.52 10.28 31 353523 1597 110234148
Cerebral artery occlusion 29.49 10.28 34 353520 1946 110233799
Diastolic dysfunction 29.43 10.28 97 353457 12307 110223438
Cardiac valve disease 29.31 10.28 64 353490 6357 110229388
Polyp 29.22 10.28 84 353470 9896 110225849
Tongue haematoma 29.06 10.28 15 353539 248 110235497
Brain stem infarction 29.05 10.28 35 353519 2099 110233646
Glomerular filtration rate decreased 29.02 10.28 175 353379 28781 110206964
Therapeutic response shortened 29.00 10.28 31 353523 29552 110206193
Anuria 28.94 10.28 154 353400 24187 110211558
Immune effector cell-associated neurotoxicity syndrome 28.88 10.28 6 353548 14776 110220969
Flushing 28.79 10.28 206 353348 104530 110131215
Immune thrombocytopenia 28.61 10.28 145 353409 22349 110213396
Hypoglycaemic coma 28.57 10.28 58 353496 5475 110230270
Acute left ventricular failure 28.52 10.28 36 353518 2265 110233480
Wound haematoma 28.45 10.28 13 353541 162 110235583
Vomiting 28.38 10.28 2516 351038 908159 109327586
Aneurysm 28.37 10.28 51 353503 4395 110231350
Haemorrhagic erosive gastritis 28.35 10.28 22 353532 760 110234985
Hepatic cyst 28.33 10.28 71 353483 7712 110228033
Subcapsular renal haematoma 28.30 10.28 24 353530 942 110234803
Spleen ischaemia 28.22 10.28 10 353544 60 110235685
Oesophagitis ulcerative 28.11 10.28 30 353524 1575 110234170
Bone marrow failure 28.02 10.28 93 353461 57755 110177990
Mitral valve calcification 27.99 10.28 31 353523 1697 110234048
Arterial disorder 27.96 10.28 35 353519 2184 110233561
Thoracic haemorrhage 27.88 10.28 15 353539 271 110235474
Bronchiectasis 27.86 10.28 46 353508 36447 110199298
Personality disorder 27.73 10.28 4 353550 12833 110222912
Leg amputation 27.71 10.28 49 353505 4169 110231576
Coronary artery embolism 27.68 10.28 16 353538 334 110235411
Hemiataxia 27.62 10.28 9 353545 40 110235705
Myoglobinaemia 27.56 10.28 13 353541 175 110235570
Respiratory symptom 27.34 10.28 7 353547 14938 110220807
Balance disorder 27.29 10.28 524 353030 116036 110119709
Proctitis 27.23 10.28 10 353544 16917 110218828
Ischaemic nephropathy 27.22 10.28 11 353543 99 110235646
Respiratory tract infection 27.13 10.28 127 353427 71490 110164255
Cardiac stress test abnormal 27.05 10.28 22 353532 814 110234931
Labelled drug-disease interaction medication error 27.02 10.28 16 353538 350 110235395
Cardiac procedure complication 26.98 10.28 16 353538 351 110235394
Dilatation atrial 26.94 10.28 46 353508 3806 110231939
Femoral neck fracture 26.94 10.28 95 353459 12472 110223273
Periorbital haematoma 26.92 10.28 24 353530 1008 110234737
Arteriosclerotic gangrene 26.80 10.28 10 353544 71 110235674
Oesophageal pain 26.79 10.28 54 353500 5071 110230674
Toe amputation 26.72 10.28 49 353505 4289 110231456
Cerebellar infarction 26.68 10.28 48 353506 4139 110231606
Haematocoele 26.67 10.28 7 353547 11 110235734
Foetal death 26.64 10.28 9 353545 16036 110219709
Aortic stenosis 26.53 10.28 97 353457 12962 110222783
Arterial intramural haematoma 26.47 10.28 14 353540 244 110235501
Pneumocystis jirovecii pneumonia 26.44 10.28 61 353493 42674 110193071
Pulseless electrical activity 26.43 10.28 115 353439 16642 110219103
Drug tolerance 26.34 10.28 10 353544 16575 110219170
Ventricle rupture 26.30 10.28 11 353543 109 110235636
Hospitalisation 26.25 10.28 310 353244 142183 110093562
Ruptured cerebral aneurysm 26.20 10.28 20 353534 674 110235071
Labelled drug-drug interaction issue 26.12 10.28 47 353507 4054 110231691
Prothrombin time prolonged 26.12 10.28 117 353437 17144 110218601
Respiratory syncytial virus infection 26.08 10.28 7 353547 14477 110221268
Ventricular extrasystoles 26.08 10.28 142 353412 22499 110213246
Chest wall haematoma 26.08 10.28 18 353536 517 110235228
Shock 26.00 10.28 274 353280 53314 110182431
Vascular occlusion 25.74 10.28 30 353524 1737 110234008
Vertigo 25.54 10.28 405 353149 86465 110149280
Cholestatic liver injury 25.51 10.28 66 353488 7310 110228435
Coronary revascularisation 25.45 10.28 10 353544 83 110235662
Panniculitis 25.42 10.28 9 353545 15573 110220172
Blood pressure diastolic abnormal 25.37 10.28 27 353527 25788 110209957
Ear haemorrhage 25.22 10.28 35 353519 2416 110233329
Gastrointestinal toxicity 25.22 10.28 3 353551 11145 110224600
Cerebral atrophy 25.20 10.28 75 353479 9010 110226735
Lethargy 25.19 10.28 430 353124 93146 110142599
Hypoglobulinaemia 25.13 10.28 13 353541 216 110235529
Brain natriuretic peptide increased 25.13 10.28 86 353468 11123 110224622
Arteriospasm coronary 25.12 10.28 75 353479 9025 110226720
Underdose 25.09 10.28 111 353443 63443 110172302
Catheter site haemorrhage 25.03 10.28 57 353497 5823 110229922
Postinfarction angina 24.83 10.28 8 353546 34 110235711
Depression 24.78 10.28 799 352755 316536 109919209
Benign gastrointestinal neoplasm 24.67 10.28 11 353543 129 110235616
Chronic coronary syndrome 24.62 10.28 14 353540 283 110235462
Psychotic disorder 24.60 10.28 82 353472 50855 110184890
Haemorrhagic cerebral infarction 24.53 10.28 27 353527 1468 110234277
Colitis 24.51 10.28 209 353345 102114 110133631
Hyperthyroidism 24.51 10.28 169 353385 29092 110206653
Impaired work ability 24.47 10.28 29 353525 26390 110209355
Oral herpes 24.40 10.28 49 353505 36031 110199714
Skin oedema 24.35 10.28 31 353523 1968 110233777
Platelet dysfunction 24.22 10.28 17 353537 502 110235243
Blood parathyroid hormone decreased 24.19 10.28 6 353548 13083 110222662
Aortic intramural haematoma 24.17 10.28 12 353542 182 110235563
Pharyngeal haemorrhage 24.11 10.28 26 353528 1381 110234364
Disability 24.11 10.28 37 353517 30186 110205559
Thyroid haemorrhage 24.10 10.28 10 353544 97 110235648
Normochromic normocytic anaemia 24.05 10.28 94 353460 12963 110222782
Device related infection 23.98 10.28 57 353497 39462 110196283
Tenosynovitis 23.96 10.28 11 353543 16272 110219473
Joint effusion 23.94 10.28 19 353535 20886 110214859
Blood glucose decreased 23.93 10.28 169 353385 29319 110206426
Implantable defibrillator insertion 23.86 10.28 24 353530 1175 110234570
Electrolyte imbalance 23.80 10.28 201 353353 36827 110198918
Prostatomegaly 23.75 10.28 46 353508 4196 110231549
Mucormycosis 23.70 10.28 3 353551 10625 110225120
Swollen tongue 23.62 10.28 296 353258 60066 110175679
Vascular procedure complication 23.60 10.28 7 353547 21 110235724
Hypochromic anaemia 23.41 10.28 39 353515 3162 110232583
Faecaloma 23.27 10.28 102 353452 14806 110220939
Troponin T increased 23.26 10.28 46 353508 4260 110231485
Pneumonia fungal 23.26 10.28 9 353545 14745 110221000
Traumatic haemorrhage 23.10 10.28 29 353525 1815 110233930
Hepatotoxicity 23.10 10.28 114 353440 63286 110172459
Cardiomegaly 23.09 10.28 166 353388 28964 110206781
Carotid bruit 23.02 10.28 19 353535 718 110235027
Cutaneous vasculitis 22.93 10.28 91 353463 12638 110223107
Arterial thrombosis 22.81 10.28 38 353516 3081 110232664
Epstein-Barr virus infection 22.79 10.28 16 353538 18722 110217023
Necrotising myositis 22.75 10.28 30 353524 1972 110233773
Skin toxicity 22.58 10.28 5 353549 11778 110223967
Hypokinesia 22.57 10.28 133 353421 21693 110214052
Caesarean section 22.51 10.28 8 353546 13809 110221936
BK virus infection 22.38 10.28 7 353547 13099 110222646
Gastrointestinal arteriovenous malformation 22.36 10.28 21 353533 944 110234801
Injection site warmth 22.33 10.28 14 353540 17391 110218354
Breast cancer 22.28 10.28 57 353497 38485 110197260
Post transplant lymphoproliferative disorder 22.28 10.28 11 353543 15602 110220143
Iliac artery stenosis 22.24 10.28 12 353542 218 110235527
Blood potassium increased 22.18 10.28 182 353372 33067 110202678
Nephrogenic systemic fibrosis 22.08 10.28 52 353502 5431 110230314
Post procedural myocardial infarction 22.07 10.28 7 353547 28 110235717
Consciousness fluctuating 22.06 10.28 31 353523 2165 110233580
Procedural complication 22.01 10.28 68 353486 8337 110227408
Ulnar nerve injury 22.01 10.28 13 353541 283 110235462
Prostatic adenoma 22.00 10.28 10 353544 123 110235622
Rhinorrhoea 21.86 10.28 216 353338 102450 110133295
Arteriovenous malformation 21.80 10.28 29 353525 1922 110233823
Peripheral artery thrombosis 21.76 10.28 43 353511 3981 110231764
Exposure to toxic agent 21.72 10.28 7 353547 12851 110222894
Unresponsive to stimuli 21.71 10.28 305 353249 63485 110172260
Liver function test abnormal 21.62 10.28 325 353229 68625 110167120
Appendicitis 21.62 10.28 36 353518 28428 110207317
Parinaud syndrome 21.62 10.28 6 353548 13 110235732
Throat irritation 21.46 10.28 93 353461 53459 110182286
Drug withdrawal syndrome 21.45 10.28 57 353497 37997 110197748
Gastric mucosal lesion 21.42 10.28 23 353531 1216 110234529
Wrong dosage formulation 21.40 10.28 5 353549 3 110235742
Contrast encephalopathy 21.37 10.28 14 353540 368 110235377
Mania 21.29 10.28 21 353533 20775 110214970
Vascular purpura 21.24 10.28 41 353513 3730 110232015
Atrioventricular block first degree 21.21 10.28 96 353458 14129 110221616
Aneurysm ruptured 21.20 10.28 22 353532 1118 110234627
Conjunctival pallor 21.15 10.28 11 353543 185 110235560
Rectal ulcer 21.13 10.28 33 353521 2534 110233211
Anastomotic infection 21.11 10.28 10 353544 136 110235609
Uveitis 21.01 10.28 23 353531 21687 110214058
Arterial injury 20.98 10.28 19 353535 815 110234930
Seronegative arthritis 20.84 10.28 8 353546 13169 110222576
Pulmonary embolism 20.80 10.28 524 353030 213950 110021795
Periorbital haemorrhage 20.70 10.28 13 353541 317 110235428
Walking aid user 20.68 10.28 30 353524 25045 110210700
Pancytopenia 20.63 10.28 511 353043 209102 110026643
Albumin urine present 20.62 10.28 18 353536 735 110235010
Blood uric acid increased 20.62 10.28 23 353531 21506 110214239
Encephalopathy 20.58 10.28 163 353391 80892 110154853
Accidental exposure to product 20.56 10.28 86 353468 49922 110185823
Vessel puncture site haemorrhage 20.48 10.28 11 353543 198 110235547
Gastrointestinal angiectasia 20.47 10.28 14 353540 396 110235349
Nail ridging 20.39 10.28 16 353538 562 110235183
Sedation complication 20.38 10.28 20 353534 19835 110215910
Haemorrhagic disorder 20.34 10.28 27 353527 1786 110233959
CYP2C19 polymorphism 20.34 10.28 7 353547 38 110235707
Blindness transient 20.30 10.28 53 353501 5903 110229842
Metallosis of globe 20.29 10.28 5 353549 5 110235740
Leukopenia 20.21 10.28 344 353210 148447 110087298
Reperfusion injury 20.14 10.28 11 353543 205 110235540
Glycosylated haemoglobin increased 20.13 10.28 137 353417 23482 110212263
Troponin I increased 20.12 10.28 50 353504 5402 110230343
Systemic infection 20 10.28 73 353481 9746 110225999
Hypoglycaemic unconsciousness 19.96 10.28 22 353532 1198 110234547
Paraplegia 19.94 10.28 54 353500 6146 110229599
Sinus node dysfunction 19.92 10.28 69 353485 8978 110226767
Type IIa hyperlipidaemia 19.87 10.28 15 353539 497 110235248
Palmar-plantar erythrodysaesthesia syndrome 19.84 10.28 66 353488 40959 110194786
Device dislocation 19.82 10.28 45 353509 31659 110204086
Inappropriate antidiuretic hormone secretion 19.81 10.28 180 353374 33671 110202074
Hepatorenal failure 19.66 10.28 23 353531 1337 110234408
Sudden visual loss 19.61 10.28 8 353546 74 110235671
Tachycardia 19.57 10.28 563 352991 226082 110009663
Nephrosclerosis 19.52 10.28 28 353526 1993 110233752
Amblyopia 19.39 10.28 12 353542 285 110235460
Left ventricular failure 19.39 10.28 80 353474 11309 110224436
Soft tissue haemorrhage 19.32 10.28 14 353540 435 110235310
Sarcoidosis 19.30 10.28 8 353546 12571 110223174
Aortic thrombosis 19.29 10.28 29 353525 2154 110233591
Injection site urticaria 19.27 10.28 16 353538 17199 110218546
Supine hypertension 19.27 10.28 14 353540 437 110235308
Forced expiratory volume decreased 19.24 10.28 9 353545 13167 110222578
Sinus congestion 19.23 10.28 43 353511 30416 110205329
Blood urea increased 19.21 10.28 264 353290 54693 110181052
Subacute hepatic failure 19.19 10.28 11 353543 226 110235519
Gastrointestinal ulcer haemorrhage 19.17 10.28 25 353529 1625 110234120
Mood swings 19.10 10.28 27 353527 22785 110212960
Eosinophil count increased 19.07 10.28 124 353430 20934 110214811
Device embolisation 19.03 10.28 9 353545 122 110235623
Bradyarrhythmia 19.01 10.28 46 353508 4888 110230857
Dyspnoea paroxysmal nocturnal 19.00 10.28 31 353523 2471 110233274
Neuralgia 18.93 10.28 85 353469 48393 110187352
Vascular device infection 18.92 10.28 15 353539 16497 110219248
Diabetic foot 18.90 10.28 41 353513 4054 110231691
Emotional distress 18.88 10.28 223 353331 44624 110191121
Sodium retention 18.81 10.28 11 353543 235 110235510
Renal artery thrombosis 18.79 10.28 15 353539 540 110235205
Echocardiogram abnormal 18.79 10.28 32 353522 2642 110233103
Incision site haematoma 18.67 10.28 10 353544 179 110235566
Strangury 18.60 10.28 11 353543 240 110235505
Gastric antral vascular ectasia 18.58 10.28 21 353533 1176 110234569
Hepatitis 18.54 10.28 191 353363 89863 110145882
Blood phosphorus increased 18.52 10.28 15 353539 16325 110219420
Heart disease congenital 18.48 10.28 16 353538 646 110235099
Product complaint 18.43 10.28 91 353463 13881 110221864
Cardiac pacemaker insertion 18.42 10.28 53 353501 6248 110229497
Nicotine dependence 18.40 10.28 22 353532 1309 110234436
Oral candidiasis 18.39 10.28 77 353477 44683 110191062
Post-traumatic amnestic disorder 18.37 10.28 7 353547 53 110235692
Dyslipidaemia 18.30 10.28 100 353454 15865 110219880
Nail pitting 18.28 10.28 14 353540 474 110235271
Metastases to central nervous system 18.14 10.28 28 353526 22789 110212956
Supraventricular tachycardia 18.12 10.28 137 353417 24285 110211460
Ventricular dysfunction 18.05 10.28 59 353495 7452 110228293
Procedural pain 18.05 10.28 56 353498 35509 110200236
Vaginal haematoma 18.04 10.28 9 353545 138 110235607
Adjustment disorder 18.02 10.28 6 353548 10789 110224956
Respiratory depression 17.99 10.28 48 353506 31953 110203792
Contraindication to medical treatment 17.98 10.28 22 353532 1341 110234404
Reocclusion 17.96 10.28 5 353549 11 110235734
Resuscitation 17.90 10.28 33 353521 2900 110232845
Mitral valve hypoplasia 17.84 10.28 6 353548 30 110235715
Shone complex 17.84 10.28 6 353548 30 110235715
Haematospermia 17.82 10.28 11 353543 260 110235485
Paraesthesia oral 17.82 10.28 52 353502 33619 110202126
Abdominal tenderness 17.78 10.28 83 353471 12374 110223371
Diabetic macroangiopathy 17.76 10.28 9 353545 143 110235602
Dry eye 17.74 10.28 105 353449 55688 110180057
Congenital aortic valve stenosis 17.68 10.28 6 353548 31 110235714
Carotid artery dissection 17.66 10.28 13 353541 414 110235331
Concomitant disease progression 17.65 10.28 37 353517 3573 110232172
Subacute cutaneous lupus erythematosus 17.60 10.28 45 353509 4949 110230796
Rectal ulcer haemorrhage 17.56 10.28 12 353542 339 110235406
Nodule 17.55 10.28 50 353504 32581 110203164
Device related thrombosis 17.53 10.28 36 353518 3426 110232319
Myocardial haemorrhage 17.52 10.28 7 353547 61 110235684
Cholecystitis acute 17.52 10.28 98 353456 15684 110220061
Tracheal haemorrhage 17.51 10.28 17 353537 797 110234948
Hyperparathyroidism secondary 17.49 10.28 35 353519 3269 110232476
Intrapericardial thrombosis 17.42 10.28 7 353547 62 110235683
Hypothyroidism 17.41 10.28 149 353405 72750 110162995
Essential hypertension 17.41 10.28 60 353494 7787 110227958
Restenosis 17.38 10.28 5 353549 13 110235732
Intracranial mass 17.34 10.28 29 353525 2359 110233386
Food allergy 17.32 10.28 23 353531 19925 110215820
Subclavian artery stenosis 17.31 10.28 11 353543 274 110235471
Therapeutic response increased 17.30 10.28 15 353539 607 110235138
Peripheral coldness 17.29 10.28 110 353444 18430 110217315
Nerve degeneration 17.28 10.28 11 353543 275 110235470
Ventricular enlargement 17.25 10.28 16 353538 708 110235037
Hyperhidrosis 17.25 10.28 748 352806 186550 110049195
Ureteric fistula 17.22 10.28 6 353548 34 110235711
Aorta hypoplasia 17.22 10.28 6 353548 34 110235711
Sneezing 17.21 10.28 49 353505 31935 110203810
Paradoxical drug reaction 17.20 10.28 5 353549 9812 110225933
Retinal haemorrhage 17.18 10.28 68 353486 9433 110226312
Cerebral artery embolism 17.17 10.28 27 353527 2085 110233660
Crying 17.17 10.28 35 353519 25593 110210152
Duodenal vascular ectasia 17.11 10.28 5 353549 14 110235731
Artery dissection 17.03 10.28 13 353541 438 110235307
Drug resistance 17.01 10.28 264 353290 56110 110179635
Lumbar radiculopathy 17.00 10.28 30 353524 2548 110233197
Sepsis 16.98 10.28 864 352690 326482 109909263
Myocarditis 16.95 10.28 45 353509 30010 110205735
Basal ganglia infarction 16.95 10.28 16 353538 724 110235021
Cardioactive drug level increased 16.94 10.28 38 353516 3844 110231901
Torsade de pointes 16.89 10.28 127 353427 22473 110213272
Anti-insulin antibody increased 16.88 10.28 8 353546 109 110235636
Coronary no-reflow phenomenon 16.86 10.28 5 353549 15 110235730
Weight fluctuation 16.83 10.28 28 353526 22117 110213628
Ovarian cyst 16.80 10.28 12 353542 13918 110221827
Laboratory test abnormal 16.79 10.28 78 353476 44001 110191744
Peripheral artery stent insertion 16.77 10.28 4 353550 3 110235742
Hepatic haemorrhage 16.74 10.28 21 353533 1313 110234432
Social problem 16.71 10.28 25 353529 1849 110233896
Altered state of consciousness 16.69 10.28 268 353286 57358 110178387
Gastroenteritis viral 16.69 10.28 48 353506 31178 110204567
Deafness transitory 16.67 10.28 19 353535 1074 110234671
Interventricular septum rupture 16.66 10.28 6 353548 38 110235707
Coronary artery aneurysm 16.66 10.28 9 353545 164 110235581
Neck pain 16.62 10.28 285 353269 122845 110112900
Product substitution error 16.59 10.28 7 353547 71 110235674
Myasthenia gravis 16.53 10.28 27 353527 21484 110214261
Sudden death 16.52 10.28 134 353420 24261 110211484
Heart sounds abnormal 16.52 10.28 22 353532 1460 110234285
Interstitial lung disease 16.50 10.28 572 352982 138762 110096983
Oesophagitis haemorrhagic 16.43 10.28 15 353539 650 110235095
Hypotonic urinary bladder 16.42 10.28 7 353547 73 110235672
Anal prolapse 16.42 10.28 7 353547 73 110235672
Aortic valve replacement 16.40 10.28 23 353531 1603 110234142
Congenital heart valve disorder 16.40 10.28 6 353548 40 110235705
Gastroenteritis eosinophilic 16.39 10.28 12 353542 379 110235366
Vascular access site haematoma 16.39 10.28 5 353549 17 110235728
Lymphadenopathy 16.38 10.28 128 353426 63707 110172038
Biliary cirrhosis 16.37 10.28 10 353544 232 110235513
Neutropenic colitis 16.33 10.28 3 353551 8062 110227683
Long QT syndrome 16.30 10.28 55 353499 7063 110228682
Acid base balance abnormal 16.29 10.28 13 353541 468 110235277
Sweat gland tumour 16.28 10.28 14 353540 560 110235185
Vascular stenosis 16.27 10.28 16 353538 762 110234983
Hallucination, visual 16.27 10.28 196 353358 39409 110196336
Eyelid bleeding 16.26 10.28 7 353547 75 110235670
Facial nerve disorder 16.20 10.28 16 353538 766 110234979
Iliac artery occlusion 16.20 10.28 12 353542 386 110235359
Haemorrhoids 16.20 10.28 180 353374 35492 110200253
Cutaneous lupus erythematosus 16.19 10.28 35 353519 3453 110232292
Arterial rupture 16.14 10.28 17 353537 879 110234866
Factor V inhibition 16.12 10.28 12 353542 389 110235356
Paralysis 16.09 10.28 95 353459 15505 110220240
Respiratory tract congestion 16.08 10.28 48 353506 30809 110204936
Encephalitis 16.07 10.28 22 353532 18817 110216928
Platelet disorder 16.06 10.28 36 353518 3639 110232106
Wound dehiscence 16.05 10.28 59 353495 7903 110227842
Electrocardiogram change 16.05 10.28 21 353533 1370 110234375
Basilar artery stenosis 16.03 10.28 6 353548 43 110235702
Haemorrhagic cyst 15.99 10.28 12 353542 394 110235351
Abdominal pain lower 15.97 10.28 186 353368 37097 110198648
Aortic aneurysm rupture 15.94 10.28 21 353533 1379 110234366
Tooth socket haemorrhage 15.87 10.28 9 353545 181 110235564
Dementia 15.86 10.28 163 353391 31510 110204235
Product dose omission in error 15.84 10.28 32 353522 23480 110212265
Vitamin B6 deficiency 15.83 10.28 14 353540 582 110235163
Rectal perforation 15.77 10.28 18 353536 1019 110234726
Sticky platelet syndrome 15.76 10.28 5 353549 20 110235725
Myxoedema coma 15.74 10.28 15 353539 687 110235058
Skin wrinkling 15.72 10.28 22 353532 1531 110234214
Gallbladder neoplasm 15.70 10.28 7 353547 82 110235663
Joint injury 15.69 10.28 70 353484 39924 110195821
Amenorrhoea 15.64 10.28 5 353549 9226 110226519
Retro-orbital neoplasm 15.63 10.28 7 353547 83 110235662
Vascular dementia 15.63 10.28 17 353537 912 110234833
Agranulocytosis 15.62 10.28 281 353273 61479 110174266
Insulin C-peptide increased 15.61 10.28 9 353545 187 110235558
Influenza virus test positive 15.60 10.28 13 353541 498 110235247
Metastases to lymph nodes 15.59 10.28 15 353539 15017 110220728
Angiogram 15.57 10.28 8 353546 131 110235614
Bacteraemia 15.57 10.28 76 353478 42314 110193431
Splenic haemorrhage 15.56 10.28 16 353538 804 110234941
Medication error 15.49 10.28 444 353110 104922 110130823
Premature labour 15.48 10.28 5 353549 9167 110226578
Hypocoagulable state 15.43 10.28 29 353525 2586 110233159
Foreign body in throat 15.41 10.28 18 353536 1045 110234700
Prostate examination abnormal 15.40 10.28 9 353545 192 110235553
Puncture site swelling 15.35 10.28 4 353550 6 110235739
Amputation 15.33 10.28 17 353537 932 110234813
Renal ischaemia 15.28 10.28 27 353527 2296 110233449
Cardiac ventricular disorder 15.23 10.28 11 353543 340 110235405
Overlap syndrome 15.18 10.28 5 353549 9054 110226691
Anal polyp 15.13 10.28 7 353547 90 110235655
Nasal polyps 15.11 10.28 12 353542 13188 110222557
Rectosigmoid cancer 15.09 10.28 11 353543 345 110235400
Mucosal erosion 15.05 10.28 30 353524 2794 110232951
Electrocardiogram abnormal 15.05 10.28 107 353447 18602 110217143
Non-small cell lung cancer recurrent 15.03 10.28 9 353545 201 110235544
Acute right ventricular failure 15.01 10.28 12 353542 433 110235312
Monoparesis 14.99 10.28 40 353514 4513 110231232
Epiglottic oedema 14.99 10.28 12 353542 434 110235311
Thalamic infarction 14.96 10.28 20 353534 1332 110234413
Lymphorrhoea 14.95 10.28 9 353545 203 110235542
Mucosal membrane hyperplasia 14.95 10.28 6 353548 53 110235692
Tuberculosis 14.92 10.28 21 353533 17753 110217992
Blood triglycerides increased 14.92 10.28 129 353425 23797 110211948
Eosinophilic colitis 14.91 10.28 14 353540 629 110235116
Lichen nitidus 14.90 10.28 8 353546 144 110235601
Congenital aortic stenosis 14.87 10.28 5 353549 25 110235720
Congenital aortic anomaly 14.87 10.28 5 353549 25 110235720
Gingival pain 14.87 10.28 17 353537 15719 110220026
Prosthetic cardiac valve thrombosis 14.86 10.28 7 353547 94 110235651
Cholecystitis 14.83 10.28 137 353417 25745 110210000
Unevaluable event 14.81 10.28 269 353285 58958 110176787
Metastases to bone 14.81 10.28 51 353503 31321 110204424
Duodenitis haemorrhagic 14.75 10.28 8 353546 147 110235598
Tardive dyskinesia 14.74 10.28 13 353541 13566 110222179
Hypercalcaemia 14.73 10.28 88 353466 46569 110189176
Septic shock 14.70 10.28 387 353167 157141 110078604
Tendon rupture 14.70 10.28 86 353468 13992 110221753
Pruritus 14.70 10.28 1631 351923 579929 109655816
Thrombocytopenic purpura 14.68 10.28 31 353523 3008 110232737
Pneumonitis 14.68 10.28 165 353389 76366 110159379
Renal cyst 14.66 10.28 104 353450 18068 110217677
Poisoning 14.65 10.28 46 353508 29059 110206686
Carotid artery stent insertion 14.63 10.28 4 353550 8 110235737
Preternatural anus 14.60 10.28 7 353547 98 110235647
Traumatic haemothorax 14.54 10.28 15 353539 757 110234988
Drug level decreased 14.52 10.28 23 353531 18525 110217220
Intestinal ischaemia 14.48 10.28 95 353459 16084 110219661
Affective disorder 14.48 10.28 9 353545 11232 110224513
Right ventricular diastolic collapse 14.47 10.28 7 353547 100 110235645
Coronary artery surgery 14.46 10.28 8 353546 153 110235592
Hysterectomy 14.46 10.28 4 353550 8110 110227635
Serum ferritin abnormal 14.46 10.28 12 353542 457 110235288
Cerebral microhaemorrhage 14.41 10.28 12 353542 459 110235286
Exophthalmos 14.41 10.28 26 353528 2247 110233498
Arterial insufficiency 14.37 10.28 11 353543 372 110235373
Aortic valve calcification 14.36 10.28 16 353538 882 110234863
Amyloidosis senile 14.29 10.28 7 353547 103 110235642
Supravalvular aortic stenosis 14.25 10.28 5 353549 29 110235716
Arteriovenous graft thrombosis 14.25 10.28 3 353551 0 110235745
Hypothrombinaemia 14.25 10.28 3 353551 0 110235745
Malabsorption from application site 14.25 10.28 3 353551 0 110235745
Mastocytic enterocolitis 14.25 10.28 3 353551 0 110235745
Peripheral revascularisation 14.25 10.28 3 353551 0 110235745
Pulmonary hypertension 14.23 10.28 252 353302 54968 110180777
Diabetic neuropathy 14.23 10.28 52 353502 6947 110228798
Photophobia 14.22 10.28 39 353515 25732 110210013
Low density lipoprotein decreased 14.18 10.28 20 353534 1402 110234343
Diffuse large B-cell lymphoma 14.14 10.28 18 353536 15880 110219865
Ascites 14.13 10.28 210 353344 92598 110143147
Device inappropriate shock delivery 14.12 10.28 6 353548 62 110235683
Nail discolouration 14.12 10.28 34 353520 3601 110232144
Gastroduodenal haemorrhage 14.11 10.28 10 353544 300 110235445
Crush syndrome 14.07 10.28 11 353543 384 110235361
Haematoma evacuation 14.05 10.28 11 353543 385 110235360
Pericardial fibrosis 14.00 10.28 9 353545 229 110235516
Hepatic encephalopathy 13.98 10.28 45 353509 28211 110207534
Exercise tolerance increased 13.97 10.28 5 353549 31 110235714
Pituitary apoplexy 13.96 10.28 10 353544 305 110235440
Language disorder 13.96 10.28 35 353519 3803 110231942
Pelvic haematoma 13.95 10.28 17 353537 1032 110234713
Adenoma benign 13.89 10.28 19 353535 1294 110234451
Hypertensive heart disease 13.77 10.28 39 353515 4557 110231188
Spinal fusion surgery 13.76 10.28 6 353548 9150 110226595
High density lipoprotein decreased 13.75 10.28 45 353509 5688 110230057
Capsular warning syndrome 13.74 10.28 4 353550 11 110235734
Puncture site reaction 13.74 10.28 4 353550 11 110235734
Peripheral artery restenosis 13.74 10.28 4 353550 11 110235734
Sinoatrial block 13.72 10.28 20 353534 1445 110234300
Transcatheter aortic valve implantation 13.71 10.28 6 353548 67 110235678
Electrocardiogram ST-T change 13.68 10.28 21 353533 1589 110234156
Large intestinal ulcer 13.62 10.28 45 353509 5716 110230029
Poor venous access 13.62 10.28 37 353517 24485 110211260
Progressive multifocal leukoencephalopathy 13.60 10.28 38 353516 24918 110210827
Oesophageal ulcer haemorrhage 13.60 10.28 16 353538 936 110234809
Second primary malignancy 13.59 10.28 23 353531 18045 110217700
International normalised ratio abnormal 13.58 10.28 48 353506 6309 110229436
Extrapyramidal disorder 13.58 10.28 47 353507 28820 110206925
Coarctation of the aorta 13.56 10.28 6 353548 69 110235676
Change of bowel habit 13.56 10.28 29 353525 2840 110232905
Eyelid haematoma 13.50 10.28 7 353547 117 110235628
Oesophageal dilatation 13.49 10.28 13 353541 604 110235141
Ligament pain 13.46 10.28 9 353545 245 110235500
Breast cancer female 13.46 10.28 12 353542 12456 110223289
Cytomegalovirus test positive 13.45 10.28 3 353551 7033 110228712
Body temperature increased 13.44 10.28 111 353443 54602 110181143
Diffuse vasculitis 13.44 10.28 7 353547 118 110235627
Anal spasm 13.43 10.28 8 353546 177 110235568
Lip oedema 13.42 10.28 54 353500 7546 110228199
Anaphylactic reaction 13.42 10.28 271 353283 114029 110121716
Bacterial infection 13.42 10.28 89 353465 45947 110189798
Candida infection 13.40 10.28 94 353460 47915 110187830
Anal stenosis 13.40 10.28 13 353541 609 110235136
Urine output decreased 13.37 10.28 109 353445 19767 110215978
Dry skin 13.32 10.28 253 353301 107400 110128345
Hypereosinophilic syndrome 13.29 10.28 15 353539 839 110234906
Catatonia 13.28 10.28 10 353544 11290 110224455
Tongue oedema 13.28 10.28 57 353497 8199 110227546
Vascular insufficiency 13.26 10.28 12 353542 514 110235231
Pain assessment 13.22 10.28 5 353549 37 110235708
Skin ulcer 13.19 10.28 281 353273 63364 110172381
Upper motor neurone lesion 13.18 10.28 10 353544 334 110235411
Dysuria 13.16 10.28 268 353286 59963 110175782
Non-cardiac chest pain 13.15 10.28 66 353488 10132 110225613
Urticarial vasculitis 13.14 10.28 16 353538 970 110234775
Mediastinal haemorrhage 13.12 10.28 6 353548 75 110235670
Hypophosphataemia 13.07 10.28 58 353496 33124 110202621
Acute respiratory failure 13.03 10.28 324 353230 74936 110160809
Carcinoid tumour of the small bowel 13.03 10.28 11 353543 429 110235316
Loss of control of legs 13.03 10.28 24 353530 2108 110233637
Blood creatinine abnormal 13.03 10.28 45 353509 5847 110229898
Peripheral artery angioplasty 13.02 10.28 4 353550 14 110235731
Livedo reticularis 13.01 10.28 43 353511 5463 110230282
Hemianopia homonymous 13.01 10.28 20 353534 1515 110234230
Immunosuppression 12.99 10.28 23 353531 17736 110218009
Cushingoid 12.97 10.28 11 353543 11701 110224044
Foot amputation 12.97 10.28 17 353537 1111 110234634
Brain compression 12.93 10.28 14 353540 747 110234998
Administration site discomfort 12.93 10.28 8 353546 190 110235555
Mitral valve stenosis 12.93 10.28 19 353535 1383 110234362
Pupil fixed 12.92 10.28 34 353520 3804 110231941
Blood creatine phosphokinase MM increased 12.89 10.28 5 353549 40 110235705
Gangrene 12.88 10.28 93 353461 16248 110219497
Affect lability 12.87 10.28 25 353529 18612 110217133
Device breakage 12.87 10.28 15 353539 13754 110221991
Laryngeal haematoma 12.85 10.28 8 353546 192 110235553
Mesenteric arterial occlusion 12.84 10.28 9 353545 265 110235480
Stroke in evolution 12.74 10.28 7 353547 132 110235613
Embolism arterial 12.74 10.28 22 353532 1837 110233908
Neutrophilia 12.73 10.28 66 353488 10263 110225482
Eyelid retraction 12.71 10.28 6 353548 81 110235664
Drug effective for unapproved indication 12.64 10.28 16 353538 14151 110221594
Tumour lysis syndrome 12.64 10.28 53 353501 30748 110204997
Procedural hypotension 12.63 10.28 26 353528 2479 110233266
Nodal arrhythmia 12.62 10.28 24 353530 2160 110233585
Thrombocytopenia 12.62 10.28 1287 352267 347598 109888147
Episcleral venous pressure increased 12.61 10.28 4 353550 16 110235729
Haemorrhagic thyroid cyst 12.61 10.28 4 353550 16 110235729
Bleeding time abnormal 12.61 10.28 4 353550 16 110235729
Arterial perforation 12.57 10.28 5 353549 43 110235702
Thrombotic stroke 12.53 10.28 14 353540 774 110234971
Dissociation 12.51 10.28 8 353546 9834 110225911
Atrial septal defect 12.45 10.28 24 353530 2181 110233564
Hypoalbuminaemia 12.43 10.28 49 353505 28925 110206820
Thrombolysis 12.41 10.28 9 353545 280 110235465
Haemodialysis 12.37 10.28 98 353456 17621 110218124
Aortic valve sclerosis 12.36 10.28 22 353532 1881 110233864
Plasma cell myeloma 12.34 10.28 135 353419 62801 110172944
Vascular pseudoaneurysm ruptured 12.33 10.28 12 353542 564 110235181
Heparin-induced thrombocytopenia test positive 12.29 10.28 7 353547 142 110235603
Tricuspid valve disease 12.24 10.28 11 353543 467 110235278
Jugular vein distension 12.24 10.28 20 353534 1596 110234149
Acanthosis 12.23 10.28 12 353542 570 110235175
Blood pressure fluctuation 12.21 10.28 167 353387 74657 110161088
Ischaemic limb pain 12.19 10.28 5 353549 47 110235698
Postresuscitation encephalopathy 12.19 10.28 5 353549 47 110235698
Ear pruritus 12.18 10.28 4 353550 7256 110228489
Oesophageal dysplasia 12.18 10.28 3 353551 3 110235742
Haemorrhagic adrenal infarction 12.18 10.28 3 353551 3 110235742
Visual field defect 12.16 10.28 64 353490 10008 110225737
Obstructive shock 12.16 10.28 7 353547 145 110235600
Paresis cranial nerve 12.09 10.28 5 353549 48 110235697
Cerebrovascular insufficiency 12.07 10.28 7 353547 147 110235598
Venous recanalisation 12.06 10.28 4 353550 19 110235726
Blindness 12.04 10.28 173 353381 36186 110199559
Mouth swelling 12.01 10.28 51 353503 7303 110228442
Intestinal polyp 12.00 10.28 25 353529 2404 110233341
Thirst 11.98 10.28 114 353440 21593 110214152
Basal cell carcinoma 11.98 10.28 90 353464 45180 110190565
Exfoliative rash 11.97 10.28 37 353517 4537 110231208
Muscle necrosis 11.97 10.28 21 353533 1776 110233969
Herpes simplex 11.92 10.28 20 353534 15744 110220001
Mydriasis 11.88 10.28 34 353520 22123 110213622
Regurgitation 11.87 10.28 31 353523 3454 110232291
Speech disorder 11.86 10.28 269 353285 61300 110174445
Parkinsonian rest tremor 11.85 10.28 10 353544 390 110235355
Catheter site pain 11.83 10.28 3 353551 6443 110229302
Dialysis 11.83 10.28 105 353449 19514 110216231
Mental status changes 11.81 10.28 323 353231 75799 110159946
Aldolase increased 11.80 10.28 8 353546 223 110235522
Silent myocardial infarction 11.79 10.28 13 353541 708 110235037
Breast cancer metastatic 11.78 10.28 11 353543 11170 110224575
Meningitis 11.77 10.28 12 353542 11690 110224055
Exsanguination 11.75 10.28 6 353548 97 110235648
Urinary straining 11.74 10.28 5 353549 52 110235693
Vessel perforation 11.73 10.28 4 353550 21 110235724
Pulmonary venous hypertension 11.72 10.28 3 353551 4 110235741
Vessel puncture site swelling 11.72 10.28 3 353551 4 110235741
Fear of injection 11.66 10.28 7 353547 8904 110226841
Small intestine polyp 11.66 10.28 5 353549 53 110235692
Cerebellar ischaemia 11.65 10.28 10 353544 399 110235346
Viral infection 11.65 10.28 111 353443 53028 110182717
Cerebral arteriosclerosis 11.64 10.28 14 353540 838 110234907
Platelet aggregation increased 11.64 10.28 6 353548 99 110235646
Diverticulitis intestinal haemorrhagic 11.63 10.28 11 353543 499 110235246
Ankylosing spondylitis 11.62 10.28 20 353534 15592 110220153
Hepatic infarction 11.61 10.28 15 353539 966 110234779
Renal haematoma 11.59 10.28 15 353539 968 110234777
Febrile bone marrow aplasia 11.57 10.28 24 353530 17441 110218304
Extrasystoles 11.56 10.28 55 353499 8263 110227482
Device issue 11.51 10.28 64 353490 34471 110201274
Functional gastrointestinal disorder 11.51 10.28 44 353510 6005 110229740
Macroangiopathy 11.51 10.28 7 353547 161 110235584
Ocular icterus 11.50 10.28 44 353510 6009 110229736
Basilar artery thrombosis 11.46 10.28 10 353544 408 110235337
Parainfluenzae virus infection 11.42 10.28 4 353550 6970 110228775
Blood pressure orthostatic abnormal 11.42 10.28 6 353548 103 110235642
Vertebral artery stenosis 11.40 10.28 8 353546 236 110235509
Skin fissures 11.38 10.28 40 353514 24418 110211327
Wound secretion 11.38 10.28 48 353506 6853 110228892
Pneumonia cytomegaloviral 11.37 10.28 4 353550 6950 110228795
Varicophlebitis 11.34 10.28 5 353549 57 110235688
Eye pruritus 11.33 10.28 60 353494 32715 110203030
Lip infection 11.32 10.28 7 353547 166 110235579
Arteriogram coronary abnormal 11.32 10.28 3 353551 5 110235740
Monoplegia 11.30 10.28 38 353516 4871 110230874
Coronary artery insufficiency 11.28 10.28 7 353547 167 110235578
Atrial flutter 11.28 10.28 123 353431 24139 110211606
Trichoglossia 11.28 10.28 14 353540 866 110234879
Injection site haemorrhage 11.27 10.28 158 353396 32870 110202875
Sinus disorder 11.27 10.28 60 353494 32668 110203077
Auricular haematoma 11.26 10.28 5 353549 58 110235687
Klebsiella infection 11.25 10.28 30 353524 19979 110215766
Facial paresis 11.25 10.28 44 353510 6069 110229676
Neurologic neglect syndrome 11.23 10.28 8 353546 9290 110226455
Herpes zoster cutaneous disseminated 11.22 10.28 11 353543 522 110235223
Substance abuse 11.20 10.28 14 353540 12449 110223296
Gastric polyps 11.20 10.28 41 353513 5482 110230263
Product odour abnormal 11.20 10.28 19 353535 1564 110234181
Product storage error 11.18 10.28 34 353520 21694 110214051
Craniocerebral injury 11.16 10.28 43 353511 5891 110229854
Pericardial mass 11.15 10.28 4 353550 25 110235720
Neutrophil count increased 11.13 10.28 65 353489 34587 110201158
Injection site induration 11.08 10.28 12 353542 11371 110224374
Chills 11.07 10.28 497 353057 190083 110045662
Angioimmunoblastic T-cell lymphoma 11.06 10.28 12 353542 642 110235103
Contrast media reaction 11.06 10.28 24 353530 2374 110233371
Duplicate therapy error 11.04 10.28 10 353544 429 110235316
Metastases to liver 11.04 10.28 67 353487 35319 110200426
Skin infection 11.03 10.28 36 353518 22473 110213272
Ocular myasthenia 10.99 10.28 13 353541 765 110234980
Spondylitis 10.98 10.28 12 353542 11326 110224419
Skull fracture 10.97 10.28 22 353532 2058 110233687
Colon cancer 10.96 10.28 90 353464 16353 110219392
Laryngeal oedema 10.95 10.28 61 353493 9746 110225999
Idiopathic pulmonary fibrosis 10.87 10.28 38 353516 4966 110230779
Toxic encephalopathy 10.87 10.28 20 353534 15194 110220551
Gestational diabetes 10.86 10.28 5 353549 7384 110228361
Pleuritic pain 10.85 10.28 22 353532 16118 110219627
Pharyngitis streptococcal 10.84 10.28 16 353538 13261 110222484
Blood blister 10.84 10.28 32 353522 3827 110231918
Nitritoid reaction 10.77 10.28 4 353550 28 110235717
Iliac vein occlusion 10.77 10.28 4 353550 28 110235717
Ageusia 10.76 10.28 103 353451 19542 110216203
Patent ductus arteriosus 10.75 10.28 7 353547 182 110235563
Increased upper airway secretion 10.74 10.28 39 353515 5193 110230552
Colitis ischaemic 10.70 10.28 95 353459 17655 110218090
Eosinophilic granulomatosis with polyangiitis 10.70 10.28 11 353543 10675 110225070
Basal ganglia haematoma 10.69 10.28 5 353549 66 110235679
Multiple sclerosis 10.68 10.28 44 353510 25654 110210091
Device leakage 10.68 10.28 22 353532 16026 110219719
Infusion site pain 10.67 10.28 25 353529 17394 110218351
Steal syndrome 10.66 10.28 3 353551 7 110235738
Eosinophilic pneumonia chronic 10.65 10.28 11 353543 556 110235189
Puncture site infection 10.62 10.28 5 353549 67 110235678
Blood growth hormone increased 10.62 10.28 15 353539 1053 110234692
Peripheral artery haematoma 10.61 10.28 6 353548 120 110235625
Stress 10.59 10.28 256 353298 105092 110130653
Scrotal swelling 10.58 10.28 16 353538 1195 110234550
Sleep apnoea syndrome 10.57 10.28 185 353369 40262 110195483
Blue toe syndrome 10.56 10.28 12 353542 676 110235069
Mast cell degranulation present 10.56 10.28 5 353549 68 110235677
Femoral nerve injury 10.56 10.28 5 353549 68 110235677
Embolic cerebral infarction 10.55 10.28 18 353536 1488 110234257
Face injury 10.54 10.28 35 353519 4457 110231288
Erectile dysfunction 10.52 10.28 98 353456 18458 110217287
Coagulation factor increased 10.49 10.28 5 353549 69 110235676
Cardiac fibrillation 10.47 10.28 15 353539 1067 110234678
Plantar fasciitis 10.45 10.28 38 353516 5063 110230682
Psychological trauma 10.43 10.28 19 353535 1654 110234091
Lymphoproliferative disorder 10.43 10.28 5 353549 7213 110228532
Choroidal haemorrhage 10.42 10.28 7 353547 192 110235553
Sensitivity to weather change 10.41 10.28 10 353544 10018 110225727
Cardiac asthma 10.39 10.28 8 353546 273 110235472
Bilirubin conjugated abnormal 10.39 10.28 7 353547 193 110235552
Vascular encephalopathy 10.39 10.28 13 353541 811 110234934
Muscle discomfort 10.39 10.28 10 353544 464 110235281
Urinary retention postoperative 10.34 10.28 8 353546 275 110235470
Hypoprothrombinaemia 10.33 10.28 14 353540 945 110234800
Rectal neoplasm 10.31 10.28 6 353548 127 110235618
Dizziness postural 10.31 10.28 81 353473 14528 110221217
Venous haemorrhage 10.30 10.28 9 353545 368 110235377
Vascular graft complication 10.30 10.28 7 353547 196 110235549
Obstructive pancreatitis 10.28 10.28 16 353538 1225 110234520
Thrombectomy 10.28 10.28 9 353545 369 110235376
Nocturia 10.28 10.28 91 353463 16899 110218846

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AC04 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
FDA PE N0000008832 Decreased Platelet Aggregation
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:50427 platelet aggregation inhibitor
CHEBI has role CHEBI:68563 P2Y<small><sub>12</sub></small> receptor antagonist
MeSH PA D006401 Hematologic Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D058921 Purinergic P2Y Receptor Antagonists
FDA EPC N0000182142 P2Y12 Platelet Inhibitor
FDA MoA N0000182143 P2Y12 Receptor Antagonists
FDA MoA N0000187062 Cytochrome P450 2C8 Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

B01AC Platelet aggregation inhibitors excl. heparin 24 drugs
abciximabacetylsalicylic acidaloxiprinberaprostcangrelorcarbasalate calciumcilostazolcloricromendipyridamoleditazoleepoprostenoleptifibatide show all 24 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Unstable angina indication 4557003
Atrial fibrillation indication 49436004 DOID:0060224
Cerebral embolism indication 75543006 DOID:4372
Non-Q wave myocardial infarction indication 314207007
Acute coronary syndrome indication 394659003
Acute ST segment elevation myocardial infarction indication 401303003
Prevention of blood clots after heart attack or stroke indication
Peripheral Arterial Thromboembolism Prevention indication
Myocardial Reinfarction Prevention indication
Prevention blood clots forming in hardened blood vessels indication
Intracranial hemorrhage contraindication 1386000
Acute hemorrhage contraindication 8573003
Retinal hemorrhage contraindication 28998008
Gastrointestinal ulcer contraindication 40845000
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Acute hepatic failure contraindication 197270009
Surgical procedure contraindication 387713003
Traumatic injury contraindication 417746004
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
P2Y purinoceptor 12 GPCR ANTAGONIST Ki 6.90 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.52 DRUG MATRIX
Cytochrome P450 2B6 Enzyme Ki 6.30 WOMBAT-PK

External reference:

IDSource
4024096 VUID
N0000022101 NUI
D00769 KEGG_DRUG
120202-66-6 SECONDARY_CAS_RN
120202-65-5 SECONDARY_CAS_RN
120202-67-7 SECONDARY_CAS_RN
236991 RXNORM
C0070166 UMLSCUI
CHEBI:37941 CHEBI
CGE PDB_CHEM_ID
CHEMBL1771 ChEMBL_ID
CHEMBL1083385 ChEMBL_ID
DB00758 DRUGBANK_ID
CHEMBL6068333 ChEMBL_ID
CHEMBL6068338 ChEMBL_ID
CHEMBL6068343 ChEMBL_ID
D000077144 MESH_DESCRIPTOR_UI
60606 PUBCHEM_CID
7150 IUPHAR_LIGAND_ID
5908 INN_ID
A74586SNO7 UNII
24922 MMSL
4480 MMSL
87809 MMSL
d04258 MMSL
007363 NDDF
007364 NDDF
013218 NDDF
015645 NDDF
015649 NDDF
108979001 SNOMEDCT_US
386952008 SNOMEDCT_US
412354008 SNOMEDCT_US
734471009 SNOMEDCT_US
734972007 SNOMEDCT_US
4021078 VANDF
4024096 VANDF
A74586SNO7 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 0024-1171 TABLET, FILM COATED 75 mg ORAL NDA 28 sections
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 0024-1332 TABLET, FILM COATED 300 mg ORAL NDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0093-7314 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0615-8014 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8625 TABLET, FILM COATED 75 mg ORAL ANDA 26 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0904-6467 TABLET, FILM COATED 300 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 13668-141 TABLET, FILM COATED 75 mg ORAL ANDA 20 sections
PLAVIX HUMAN PRESCRIPTION DRUG LABEL 1 16590-288 TABLET, FILM COATED 75 mg ORAL NDA 12 sections
Clopidogrel Human Prescription Drug Label 1 16714-052 TABLET 75 mg ORAL ANDA 27 sections
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 21695-665 TABLET, FILM COATED 75 mg ORAL NDA 28 sections
CLOPIDOGREL HUMAN PRESCRIPTION DRUG LABEL 1 31722-758 TABLET 75 mg ORAL ANDA 26 sections
CLOPIDOGREL HUMAN PRESCRIPTION DRUG LABEL 1 31722-759 TABLET 300 mg ORAL ANDA 26 sections
clopidogrel Human Prescription Drug Label 1 31722-901 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
clopidogrel Human Prescription Drug Label 1 31722-902 TABLET, FILM COATED 300 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 33261-987 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel Human Prescription Drug Label 1 33342-060 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 42543-713 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 42543-714 TABLET 300 mg ORAL ANDA 27 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 43063-371 TABLET, FILM COATED 75 mg ORAL ANDA 20 sections
clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 43353-269 TABLET, FILM COATED 75 mg ORAL ANDA 29 sections
Clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 43598-121 TABLET, FILM COATED 75 mg ORAL ANDA 26 sections
Clopidogrel bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 43598-122 TABLET, FILM COATED 300 mg ORAL ANDA 26 sections
Clopidogrel Bisulfate Human Prescription Drug Label 1 47335-894 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel Bisulfate Human Prescription Drug Label 1 50090-1300 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel Human Prescription Drug Label 1 50090-2082 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel Human Prescription Drug Label 1 50090-5781 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel Human Prescription Drug Label 1 50090-5868 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel Human Prescription Drug Label 1 50090-6567 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel Human Prescription Drug Label 1 50090-6568 TABLET 75 mg ORAL ANDA 27 sections
CLOPIDOGREL Human Prescription Drug Label 1 50090-7466 TABLET 75 mg ORAL ANDA 27 sections