atorvastatin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 257 134523-00-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CI-981
  • CI981
  • atorvastatin calcium hydrate
  • atorvastatin calcium anhydrous
  • atorvastatin
  • atorvastatin acid
  • cardyl
  • atorvastatin calcium
  • atorvastatin calcium trihydrate
A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.
  • Molecular weight: 558.65
  • Formula: C33H35FN2O5
  • CLOGP: 4.46
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 4
  • TPSA: 111.79
  • ALOGS: -5.95
  • ROTB: 12

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.05 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.02 mg/mL Hosey CM, Chan R, Benet LZ
EoM (Fraction excreted unchanged in urine) 1 % Hosey CM, Chan R, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Dec. 17, 1996 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1072.28 9.97 2446 304659 120642 46258315
Rhabdomyolysis 719.89 9.97 1115 305990 40794 46338163
Immune-mediated myositis 650.43 9.97 240 306865 676 46378281
Maternal exposure during pregnancy 503.01 9.97 47 307058 102502 46276455
Drug ineffective 480.95 9.97 2566 304539 675272 45703685
Exposure during pregnancy 470.97 9.97 74 307031 108138 46270819
Rheumatoid arthritis 422.50 9.97 578 306527 239637 46139320
Acute kidney injury 381.38 9.97 2756 304349 233099 46145858
Myopathy 366.01 9.97 367 306738 8514 46370443
Blood creatine phosphokinase increased 349.96 9.97 643 306462 27081 46351876
Completed suicide 348.19 9.97 270 306835 145650 46233307
Myocardial infarction 314.10 9.97 1373 305732 96155 46282802
Off label use 302.03 9.97 1379 305726 378462 46000495
Cerebrovascular accident 287.12 9.97 1371 305734 99668 46279289
Treatment failure 284.37 9.97 128 306977 92959 46285998
Pemphigus 241.14 9.97 14 307091 45260 46333697
Contraindicated product administered 236.35 9.97 115 306990 79832 46299125
Necrotising myositis 223.79 9.97 84 307021 252 46378705
Acute myocardial infarction 222.52 9.97 583 306522 31341 46347616
Muscular weakness 206.64 9.97 1168 305937 90676 46288281
Drug hypersensitivity 206.43 9.97 2481 304624 241344 46137613
Toxicity to various agents 196.59 9.97 723 306382 211043 46167914
Systemic lupus erythematosus 172.02 9.97 108 306997 65072 46313885
Drug interaction 164.15 9.97 2049 305056 201045 46177912
Therapeutic product effect decreased 160.33 9.97 184 306921 82417 46296540
Hand deformity 154.11 9.97 22 307083 34552 46344405
Synovitis 153.34 9.97 107 306998 60968 46317989
Coronary artery disease 151.59 9.97 528 306577 33224 46345733
Febrile neutropenia 150.19 9.97 244 306861 94383 46284574
Muscle spasms 148.66 9.97 1347 305758 121766 46257191
Hypomagnesaemia 147.07 9.97 398 306707 21812 46357145
Polymyositis 141.62 9.97 103 307002 1512 46377445
Foetal exposure during pregnancy 138.37 9.97 19 307086 30728 46348229
Drug abuse 136.85 9.97 129 306976 63279 46315678
Infusion related reaction 131.68 9.97 294 306811 100914 46278043
Glossodynia 129.34 9.97 65 307040 44308 46334649
Abortion spontaneous 128.64 9.97 63 307042 43583 46335374
Device expulsion 126.39 9.97 16 307089 27526 46351431
Blood glucose increased 125.02 9.97 857 306248 71156 46307801
Myositis 124.18 9.97 202 306903 7702 46371255
Blood cholesterol increased 120.90 9.97 553 306552 39460 46339497
Intentional overdose 119.29 9.97 151 306954 64793 46314164
Rheumatoid factor positive 113.16 9.97 5 307100 20456 46358501
Hyperkalaemia 112.07 9.97 642 306463 50067 46328890
Pregnancy 110.49 9.97 22 307083 27115 46351842
Transient ischaemic attack 110.41 9.97 489 306616 34414 46344543
Lactic acidosis 108.73 9.97 477 306628 33432 46345525
Anti-cyclic citrullinated peptide antibody positive 108.16 9.97 4 307101 19141 46359816
Product use issue 102.27 9.97 302 306803 94342 46284615
Hypertensive emergency 102.26 9.97 85 307020 1533 46377424
Pain 102.16 9.97 2375 304730 474573 45904384
Low density lipoprotein increased 100.65 9.97 158 306947 5842 46373115
Neutropenia 96.31 9.97 550 306555 142654 46236303
Hypoglycaemia 96.22 9.97 650 306455 53699 46325258
Fall 91.93 9.97 2823 304282 326274 46052683
Pyrexia 91.10 9.97 1681 305424 347121 46031836
Drug intolerance 90.38 9.97 581 306524 146468 46232489
Malignant neoplasm progression 89.94 9.97 182 306923 64744 46314213
Chest pain 89.37 9.97 1643 305462 174681 46204276
Liver function test abnormal 86.54 9.97 563 306542 45924 46333033
Angina unstable 86.46 9.97 168 306937 7380 46371577
Ischaemic stroke 86.11 9.97 274 306831 16448 46362509
Hyponatraemia 85.88 9.97 1032 306073 100300 46278657
Angina pectoris 85.34 9.97 376 306729 26399 46352558
Caesarean section 83.00 9.97 7 307098 16596 46362361
Premature baby 81.96 9.97 11 307094 18101 46360856
Atrial fibrillation 77.56 9.97 1031 306074 102559 46276398
Autoimmune hepatitis 75.39 9.97 162 306943 7652 46371305
Death 75.05 9.97 1659 305446 333889 46045068
Diabetic ketoacidosis 73.37 9.97 275 306830 17935 46361022
Premature delivery 72.78 9.97 27 307078 22042 46356915
Cholestasis 72.74 9.97 360 306745 26533 46352424
Coronary artery occlusion 72.53 9.97 163 306942 7939 46371018
Cardiac failure congestive 71.96 9.97 921 306184 90829 46288128
Drug-induced liver injury 71.05 9.97 343 306762 25025 46353932
Infection 68.89 9.97 555 306550 133037 46245920
Gastrointestinal haemorrhage 68.19 9.97 794 306311 76579 46302378
Intentional self-injury 68.05 9.97 37 307068 24129 46354828
International normalised ratio increased 64.92 9.97 529 306576 46354 46332603
Sinusitis 64.24 9.97 545 306560 129223 46249734
Rash 63.70 9.97 1822 305283 354690 46024267
Neurologic neglect syndrome 63.01 9.97 45 307060 641 46378316
Carotid artery thrombosis 62.75 9.97 46 307059 684 46378273
Injection site pain 61.98 9.97 431 306674 106721 46272236
Asthenia 61.47 9.97 2566 304539 308509 46070448
Injection site erythema 61.39 9.97 266 306839 74161 46304796
Injection site reaction 61.38 9.97 140 306965 47709 46331248
Glycosylated haemoglobin increased 61.38 9.97 184 306921 10692 46368265
Suicide attempt 61.34 9.97 173 306932 54863 46324094
Muscle necrosis 61.22 9.97 41 307064 523 46378434
Confusional state 60.99 9.97 1429 305676 158463 46220494
Arthropathy 60.36 9.97 319 306786 84381 46294576
Renal failure 60.14 9.97 1066 306039 112528 46266429
Cerebral haemorrhage 58.66 9.97 353 306752 28018 46350939
Infective pulmonary exacerbation of cystic fibrosis 58.60 9.97 3 307102 10804 46368153
Myocardial ischaemia 58.58 9.97 201 306904 12548 46366409
Hepatitis cholestatic 58.29 9.97 133 306972 6544 46372413
Hypersensitivity 57.42 9.97 672 306433 149649 46229308
Acute coronary syndrome 56.99 9.97 172 306933 10032 46368925
Hepatitis 56.83 9.97 385 306720 31830 46347127
Syncope 55.65 9.97 984 306121 103819 46275138
Blood triglycerides increased 55.22 9.97 187 306918 11596 46367361
Wound 55.09 9.97 125 306980 42677 46336280
Hemiplegia 54.91 9.97 133 306972 6805 46372152
Amnesia 54.58 9.97 464 306641 41167 46337790
Alopecia 54.25 9.97 747 306358 161667 46217290
Device dislocation 53.65 9.97 39 307066 21763 46357194
C-reactive protein increased 53.61 9.97 201 306904 58389 46320568
Joint swelling 52.93 9.97 771 306334 165302 46213655
Bradycardia 52.60 9.97 667 306438 65631 46313326
Diabetes mellitus 52.53 9.97 532 306573 49533 46329424
Product use in unapproved indication 52.25 9.97 363 306742 89910 46289047
Leukopenia 51.18 9.97 253 306852 68090 46310867
Melaena 50.25 9.97 334 306771 27438 46351519
Atrioventricular block 50.14 9.97 127 306978 6684 46372273
Injection site swelling 50.12 9.97 120 306985 40207 46338750
Pericarditis 50.08 9.97 50 307055 23877 46355080
Dizziness 49.43 9.97 2724 304381 337690 46041267
Incorrect dosage administered 48.91 9.97 58 307047 1633 46377324
Coronary artery stenosis 48.12 9.97 100 307005 4613 46374344
Coma 47.23 9.97 210 306895 58139 46320818
Condition aggravated 47.15 9.97 1239 305866 243813 46135144
Cardiac disorder 46.96 9.97 468 306637 43390 46335567
Therapeutic product effect incomplete 46.35 9.97 312 306793 77841 46301116
Pancreatitis acute 45.53 9.97 300 306805 24572 46354385
Drug resistance 45.50 9.97 29 307076 17339 46361618
Decreased appetite 45.32 9.97 1629 305476 192207 46186750
High density lipoprotein decreased 44.57 9.97 57 307048 1737 46377220
Hepatitis acute 44.51 9.97 137 306968 8077 46370880
Red blood cell sedimentation rate abnormal 44.50 9.97 17 307088 13632 46365325
Disease progression 44.46 9.97 385 306720 90915 46288042
Rectal haemorrhage 43.30 9.97 413 306692 37842 46341115
Carotid arteriosclerosis 43.16 9.97 42 307063 938 46378019
Live birth 42.84 9.97 8 307097 10322 46368635
Cytomegalovirus infection 42.67 9.97 34 307071 18110 46360847
Premature labour 42.32 9.97 11 307094 11288 46367669
Intentional product use issue 42.09 9.97 191 306914 52589 46326368
Chromaturia 41.29 9.97 202 306903 14817 46364140
Pancytopenia 41.28 9.97 359 306746 84699 46294258
Respiratory arrest 40.94 9.97 102 307003 33714 46345243
Orthostatic hypotension 40.73 9.97 290 306815 24368 46354589
Chronic kidney disease 40.36 9.97 429 306676 40442 46338515
Accidental exposure to product 38.71 9.97 49 307056 21032 46357925
Pemphigoid 38.69 9.97 103 307002 5588 46373369
Hepatocellular injury 38.67 9.97 329 306776 29193 46349764
Neurotoxicity 38.62 9.97 21 307084 13696 46365261
Jaundice 38.60 9.97 323 306782 28522 46350435
Abortion induced 38.40 9.97 10 307095 10250 46368707
Haematochezia 38.18 9.97 396 306709 37097 46341860
Neutrophil count decreased 37.79 9.97 152 306953 43274 46335683
Diabetes mellitus inadequate control 37.24 9.97 179 306926 13035 46365922
Muscle disorder 37.00 9.97 85 307020 4201 46374756
Swelling 36.93 9.97 586 306519 123925 46255032
Autoimmune myositis 36.52 9.97 15 307090 61 46378896
Uterine perforation 36.50 9.97 3 307102 7264 46371693
Stomatitis 36.45 9.97 281 306824 68016 46310941
Muscle atrophy 36.41 9.97 104 307001 5880 46373077
Seizure 36.21 9.97 580 306525 122474 46256483
Gestational diabetes 36.21 9.97 3 307102 7216 46371741
Abdominal discomfort 36.14 9.97 739 306366 150426 46228531
Hepatitis toxic 35.86 9.97 68 307037 2932 46376025
Pre-eclampsia 35.82 9.97 5 307100 7989 46370968
Bone erosion 35.74 9.97 9 307096 9434 46369523
Product substitution issue 35.65 9.97 194 306911 14837 46364120
Adjustment disorder 35.63 9.97 45 307060 1354 46377603
Mucosal inflammation 35.47 9.97 134 306971 38842 46340115
Renal impairment 35.19 9.97 686 306419 73686 46305271
Pain in extremity 35.17 9.97 2058 305047 256622 46122335
Migraine 35.12 9.97 293 306812 69733 46309224
Mixed liver injury 34.84 9.97 69 307036 3074 46375883
Atrioventricular block complete 34.83 9.97 120 306985 7507 46371450
Hyperlipidaemia 34.78 9.97 225 306880 18314 46360643
Vascular stent stenosis 34.70 9.97 29 307076 527 46378430
Arterial stenosis 34.65 9.97 31 307074 620 46378337
Blood alkaline phosphatase increased 34.23 9.97 405 306700 39204 46339753
Anaemia 33.83 9.97 2030 305075 253749 46125208
Large intestine polyp 33.58 9.97 121 306984 7740 46371217
Swollen tongue 33.28 9.97 316 306789 28916 46350041
Labile blood pressure 33.05 9.97 48 307057 1655 46377302
Polymyalgia rheumatica 32.98 9.97 57 307048 2285 46376672
Amenorrhoea 32.67 9.97 9 307096 8886 46370071
Respiratory depression 32.31 9.97 18 307087 11582 46367375
Carotid artery stenosis 32.15 9.97 90 307015 5030 46373927
Therapeutic response decreased 30.44 9.97 163 306942 42982 46335975
Hyperglycaemia 30.04 9.97 358 306747 34713 46344244
Foetal death 30.02 9.97 10 307095 8733 46370224
Injection site pruritus 29.82 9.97 147 306958 39596 46339361
Hypocalcaemia 29.73 9.97 288 306817 26497 46352460
Peripheral artery stenosis 29.52 9.97 26 307079 509 46378448
Blood loss anaemia 29.44 9.97 123 306982 8434 46370523
Stillbirth 29.23 9.97 4 307101 6487 46372470
Febrile bone marrow aplasia 29.14 9.97 5 307100 6857 46372100
Blood cholesterol abnormal 28.96 9.97 53 307052 2224 46376733
Oedema peripheral 28.91 9.97 1306 305799 158400 46220557
Overdose 28.89 9.97 484 306621 101495 46277462
Myoglobin blood increased 28.63 9.97 41 307064 1395 46377562
Acute myeloid leukaemia 28.63 9.97 37 307068 15741 46363216
Myocardial necrosis marker increased 28.54 9.97 43 307062 1533 46377424
Device issue 28.53 9.97 55 307050 19925 46359032
Gait disturbance 28.31 9.97 1197 305908 144066 46234891
Metastases to bone 27.76 9.97 45 307060 17431 46361526
Multiple sclerosis relapse 27.63 9.97 163 306942 41962 46336995
Cell death 27.52 9.97 52 307053 2236 46376721
Low density lipoprotein abnormal 27.50 9.97 14 307091 102 46378855
Subacute cutaneous lupus erythematosus 27.48 9.97 47 307058 1868 46377089
Suicidal ideation 27.33 9.97 238 306867 56144 46322813
Gamma-glutamyltransferase increased 27.18 9.97 324 306781 31416 46347541
Myoglobinuria 27.05 9.97 18 307087 227 46378730
Aldolase increased 26.81 9.97 15 307090 135 46378822
Body height decreased 26.66 9.97 130 306975 9522 46369435
Blood creatine phosphokinase MB increased 26.62 9.97 37 307068 1224 46377733
Ischaemic cardiomyopathy 26.20 9.97 55 307050 2555 46376402
Pneumonia 26.12 9.97 2126 304979 374194 46004763
Maternal drugs affecting foetus 25.82 9.97 3 307102 5515 46373442
Personality disorder 25.81 9.97 61 307044 3072 46375885
Inappropriate antidiuretic hormone secretion 25.75 9.97 170 306935 13932 46365025
Alanine aminotransferase increased 25.72 9.97 763 306342 87688 46291269
Nasopharyngitis 25.67 9.97 794 306311 153204 46225753
Oligohydramnios 25.50 9.97 3 307102 5462 46373495
Cardio-respiratory arrest 25.48 9.97 261 306844 59608 46319349
Hemiparesis 25.42 9.97 222 306883 19847 46359110
Haematoma 25.41 9.97 321 306784 31551 46347406
Drug dependence 24.90 9.97 59 307046 19842 46359115
Psoriatic arthropathy 24.81 9.97 139 306966 36240 46342717
Dyspnoea 24.78 9.97 3807 303298 511741 45867216
Gynaecomastia 24.74 9.97 14 307091 129 46378828
Euglycaemic diabetic ketoacidosis 24.48 9.97 46 307059 1970 46376987
Blood glucose decreased 24.46 9.97 210 306895 18682 46360275
Ankylosing spondylitis 24.40 9.97 7 307098 6730 46372227
Dermatomyositis 24.40 9.97 46 307059 1975 46376982
Thrombocytopenia 24.30 9.97 640 306465 125941 46253016
Device related infection 24.29 9.97 65 307040 20976 46357981
Haemorrhage intracranial 24.22 9.97 155 306950 12569 46366388
Lichen planopilaris 24.18 9.97 6 307099 0 46378957
Urine output decreased 24.18 9.97 140 306965 10957 46368000
Traumatic coma 24.07 9.97 11 307094 61 46378896
Duodenal ulcer perforation 23.96 9.97 13 307092 8489 46370468
Stent placement 23.81 9.97 64 307041 3492 46375465
Balance disorder 23.75 9.97 574 306531 63947 46315010
Aortic stenosis 23.66 9.97 73 307032 4309 46374648
White blood cell count decreased 23.55 9.97 560 306545 111671 46267286
Hypercholesterolaemia 23.54 9.97 143 306962 11387 46367570
Acne 23.40 9.97 61 307044 19858 46359099
Cholestatic liver injury 23.31 9.97 46 307059 2044 46376913
Bone marrow failure 23.27 9.97 108 306997 29561 46349396
Stevens-Johnson syndrome 23.26 9.97 77 307028 23220 46355737
Upper gastrointestinal haemorrhage 23.24 9.97 189 306916 16549 46362408
Hypovolaemic shock 23.19 9.97 81 307024 5102 46373855
Antimitochondrial antibody positive 22.97 9.97 11 307094 69 46378888
Cerebral infarction 22.94 9.97 245 306860 23121 46355836
Anuria 22.85 9.97 141 306964 11290 46367667
Liver disorder 22.80 9.97 358 306747 36888 46342069
Dysarthria 22.79 9.97 360 306745 37138 46341819
Lymphocyte count decreased 22.62 9.97 89 307016 25500 46353457
Transplant rejection 22.54 9.97 18 307087 9578 46369379
Diabetic retinopathy 22.52 9.97 48 307057 2254 46376703
Poisoning 22.26 9.97 36 307069 13958 46364999
Mydriasis 22.14 9.97 22 307083 10531 46368426
Haematotoxicity 22.00 9.97 9 307096 6924 46372033
Intestinal haemorrhage 21.89 9.97 57 307048 3051 46375906
Cardiac failure 21.73 9.97 684 306421 79264 46299693
Diabetic nephropathy 21.54 9.97 35 307070 1333 46377624
Labelled drug-drug interaction medication error 21.52 9.97 117 306988 8944 46370013
Coronary artery thrombosis 21.40 9.97 32 307073 1133 46377824
Type 2 diabetes mellitus 21.23 9.97 212 306893 19663 46359294
Knee arthroplasty 21.12 9.97 82 307023 23583 46355374
Psychotic disorder 21.08 9.97 77 307028 22544 46356413
Eosinophilia 21.02 9.97 206 306899 19011 46359946
Platelet count decreased 21.01 9.97 499 306606 99525 46279432
Flatulence 21.00 9.97 286 306819 28592 46350365
Peripheral nerve palsy 20.95 9.97 7 307098 13 46378944
Head injury 20.88 9.97 251 306854 24385 46354572
Dehydration 20.83 9.97 1265 305840 158275 46220682
Aspartate aminotransferase increased 20.78 9.97 671 306434 78029 46300928
Pathogen resistance 20.69 9.97 7 307098 6053 46372904
Panniculitis 20.52 9.97 6 307099 5698 46373259
Hypertensive cardiomyopathy 20.46 9.97 15 307090 223 46378734
Ocular myasthenia 20.44 9.97 13 307092 151 46378806
Haemophagocytic lymphohistiocytosis 20.42 9.97 15 307090 8327 46370630
Neoplasm progression 20.42 9.97 98 307007 26585 46352372
Cerebral haematoma 20.29 9.97 58 307047 3281 46375676
Ascites 20.24 9.97 149 306956 36435 46342522
Plasma cell myeloma 20.14 9.97 191 306914 44287 46334670
Complication of device insertion 20.14 9.97 4 307101 4940 46374017
Mitral valve incompetence 20.09 9.97 201 306904 18651 46360306
Metastases to liver 20.06 9.97 64 307041 19521 46359436
Carotid artery occlusion 20.01 9.97 50 307055 2609 46376348
Embolic stroke 20.00 9.97 61 307044 3578 46375379
Blood pressure increased 19.99 9.97 1022 306083 125644 46253313
Myelosuppression 19.99 9.97 13 307092 7690 46371267
Faeces discoloured 19.88 9.97 183 306922 16604 46362353
Tuberculosis 19.76 9.97 23 307082 10242 46368715
Metastases to central nervous system 19.66 9.97 27 307078 11194 46367763
Discomfort 19.64 9.97 204 306901 46466 46332491
Hepatic function abnormal 19.63 9.97 327 306778 34094 46344863
Retinal artery occlusion 19.58 9.97 34 307071 1368 46377589
Chloropsia 19.58 9.97 8 307097 32 46378925
Blood creatine phosphokinase abnormal 19.57 9.97 14 307091 200 46378757
Pulmonary renal syndrome 19.56 9.97 18 307087 374 46378583
Hip arthroplasty 19.40 9.97 58 307047 18054 46360903
Cardiotoxicity 19.35 9.97 10 307095 6712 46372245
Headache 19.33 9.97 2806 304299 475546 45903411
No adverse event 19.13 9.97 139 306966 34092 46344865
Sensory loss 19.09 9.97 93 307012 6809 46372148
Cardiac murmur 18.76 9.97 134 306971 11270 46367687
Aspergillus infection 18.75 9.97 11 307094 6879 46372078
Oral herpes 18.74 9.97 65 307040 19325 46359632
Dyslipidaemia 18.57 9.97 79 307026 5461 46373496
Renal disorder 18.48 9.97 262 306843 26424 46352533
Chest wall haematoma 18.43 9.97 11 307094 113 46378844
Fungal infection 18.43 9.97 116 306989 29404 46349553
Musculoskeletal stiffness 18.40 9.97 497 306608 97496 46281461
Hepatic steatosis 18.26 9.97 240 306865 23802 46355155
Dysstasia 18.17 9.97 187 306918 17481 46361476
Lipids abnormal 18.07 9.97 15 307090 270 46378687
Candida infection 18.02 9.97 80 307025 22160 46356797
IIIrd nerve paresis 17.97 9.97 10 307095 89 46378868
Immunodeficiency 17.92 9.97 37 307068 13069 46365888
Pallor 17.91 9.97 232 306873 22934 46356023
Incorrect route of product administration 17.88 9.97 52 307053 16331 46362626
Extraocular muscle paresis 17.86 9.97 12 307093 154 46378803
Periorbital haematoma 17.85 9.97 24 307081 769 46378188
Dementia 17.80 9.97 163 306942 14767 46364190
Macular degeneration 17.77 9.97 94 307011 7111 46371846
Mouth swelling 17.69 9.97 59 307046 3630 46375327
Food allergy 17.59 9.97 12 307093 6921 46372036
Blood creatinine increased 17.55 9.97 641 306464 75762 46303195
Blood pressure inadequately controlled 17.30 9.97 66 307039 4340 46374617
Cervix neoplasm 17.25 9.97 13 307092 202 46378755
Pancreatitis 17.24 9.97 392 306713 43235 46335722
Flushing 17.22 9.97 310 306795 64304 46314653
Hallucination, gustatory 17.19 9.97 9 307096 70 46378887
Sepsis 17.06 9.97 726 306379 135288 46243669
Cerebral microangiopathy 17.04 9.97 13 307092 206 46378751
Abnormal dreams 17.04 9.97 121 306984 10158 46368799
Helicobacter infection 17.02 9.97 32 307073 11704 46367253
Menstruation irregular 17.02 9.97 11 307094 6528 46372429
Glomerular filtration rate abnormal 16.94 9.97 19 307086 503 46378454
Hypertransaminasaemia 16.91 9.97 56 307049 3432 46375525
Palmar-plantar erythrodysaesthesia syndrome 16.91 9.97 73 307032 20378 46358579
Epstein-Barr virus infection 16.87 9.97 12 307093 6772 46372185
Memory impairment 16.84 9.97 645 306460 76692 46302265
Generalised tonic-clonic seizure 16.71 9.97 107 306998 27015 46351942
Sinus bradycardia 16.70 9.97 151 306954 13631 46365326
Angioedema 16.66 9.97 357 306748 38985 46339972
Hypertension 16.65 9.97 1504 305601 194852 46184105
Post viral fatigue syndrome 16.58 9.97 11 307094 138 46378819
Impaired healing 16.55 9.97 158 306947 36585 46342372
Eating disorder 16.48 9.97 158 306947 14496 46364461
Tumour lysis syndrome 16.47 9.97 14 307091 7222 46371735
Spinal epidural haematoma 16.45 9.97 23 307082 765 46378192
Device difficult to use 16.44 9.97 17 307088 7987 46370970
Apolipoprotein A-I decreased 16.40 9.97 7 307098 32 46378925
Fibromyalgia 16.33 9.97 157 306948 36306 46342651
Device breakage 16.31 9.97 24 307081 9668 46369289
Tachycardia 16.26 9.97 515 306590 99107 46279850
Inclusion body myositis 16.25 9.97 5 307100 6 46378951
Spur cell anaemia 16.23 9.97 6 307099 17 46378940
Lipoprotein (a) increased 16.23 9.97 7 307098 33 46378924
Cholangiolitis 16.12 9.97 4 307101 0 46378957
Poisoning deliberate 16.09 9.97 17 307088 7909 46371048
Subarachnoid haemorrhage 16.06 9.97 127 306978 11026 46367931
Staphylococcal infection 16.03 9.97 154 306951 35617 46343340
Coronary artery restenosis 16.02 9.97 17 307088 422 46378535
Unintentional medical device removal 16.00 9.97 5 307100 4548 46374409
Injection site rash 15.97 9.97 52 307053 15761 46363196
Pulmonary embolism 15.93 9.97 569 306536 108016 46270941
Haemorrhagic transformation stroke 15.86 9.97 28 307077 1142 46377815
Left atrial enlargement 15.85 9.97 13 307092 230 46378727
Arteriosclerosis 15.80 9.97 114 306991 9619 46369338
Cholecystitis chronic 15.79 9.97 28 307077 10471 46368486
Tubulointerstitial nephritis and uveitis syndrome 15.73 9.97 10 307095 116 46378841
Menstrual disorder 15.72 9.97 4 307101 4164 46374793
Myelodysplastic syndrome 15.64 9.97 52 307053 15659 46363298
Vascular stenosis 15.63 9.97 9 307096 86 46378871
Quadriplegia 15.61 9.97 35 307070 1702 46377255
Bacteraemia 15.48 9.97 45 307060 14134 46364823
Acute respiratory distress syndrome 15.36 9.97 83 307022 21839 46357118
Vaginal haemorrhage 15.28 9.97 102 307003 25502 46353455
Breast cancer metastatic 15.23 9.97 43 307062 13635 46365322
Mixed anxiety and depressive disorder 15.17 9.97 10 307095 124 46378833
Chronic obstructive pulmonary disease 15.11 9.97 491 306614 57142 46321815
Saliva altered 15.09 9.97 14 307091 294 46378663
Enthesopathy 15.03 9.97 6 307099 4684 46374273
Ventricular septal defect 14.97 9.97 4 307101 4030 46374927
Large intestinal haemorrhage 14.92 9.97 27 307078 1123 46377834
Deep vein thrombosis 14.87 9.97 405 306700 79368 46299589
Pelvic pain 14.83 9.97 34 307071 11568 46367389
Lipids increased 14.81 9.97 25 307080 983 46377974
Albuminuria 14.78 9.97 12 307093 209 46378748
Complication associated with device 14.76 9.97 52 307053 15389 46363568
Asthma 14.75 9.97 474 306631 91068 46287889
Haematemesis 14.75 9.97 269 306836 28537 46350420
Diverticulum 14.73 9.97 125 306980 11081 46367876
Aphasia 14.71 9.97 267 306838 28300 46350657
Heart injury 14.71 9.97 28 307077 1211 46377746
Eructation 14.59 9.97 90 307015 7205 46371752
Thrombotic microangiopathy 14.54 9.97 20 307085 8286 46370671
Polyuria 14.54 9.97 89 307016 7106 46371851
Urinary tract obstruction 14.49 9.97 34 307071 1704 46377253
Gastric ulcer 14.48 9.97 213 306892 21650 46357307
Encephalopathy 14.47 9.97 146 306959 33443 46345514
Abnormal loss of weight 14.46 9.97 68 307037 4907 46374050
Angiopathy 14.45 9.97 61 307044 4202 46374755
Lower gastrointestinal haemorrhage 14.45 9.97 90 307015 7230 46371727
Immune reconstitution inflammatory syndrome 14.40 9.97 10 307095 5715 46373242
High density lipoprotein abnormal 14.35 9.97 7 307098 46 46378911
Low birth weight baby 14.33 9.97 9 307096 5425 46373532
Arteriovenous fistula occlusion 14.30 9.97 14 307091 315 46378642
Acute cutaneous lupus erythematosus 14.28 9.97 11 307094 177 46378780
Arterial occlusive disease 14.21 9.97 66 307039 4738 46374219
Herpes zoster 14.14 9.97 339 306766 67533 46311424
Injection site warmth 14.11 9.97 45 307060 13727 46365230
Loss of personal independence in daily activities 14.11 9.97 278 306827 56905 46322052
Unintended pregnancy 14.09 9.97 10 307095 5650 46373307
Arterial insufficiency 14.09 9.97 10 307095 141 46378816
Ear infection 14.07 9.97 91 307014 22922 46356035
Hepatic ischaemia 14.05 9.97 17 307088 489 46378468
Weight decreased 13.98 9.97 1588 305517 209261 46169696
Gastrointestinal toxicity 13.93 9.97 61 307044 4270 46374687
Cardiac failure acute 13.92 9.97 96 307009 7982 46370975
Carotid artery disease 13.88 9.97 33 307072 1668 46377289
Muscle enzyme increased 13.83 9.97 9 307096 109 46378848
Presyncope 13.83 9.97 232 306873 24222 46354735
Blood urea increased 13.78 9.97 239 306866 25113 46353844
Prothrombin consumption time prolonged 13.75 9.97 7 307098 51 46378906
Acute pulmonary oedema 13.73 9.97 94 307011 7797 46371160
Ketoacidosis 13.73 9.97 57 307048 3898 46375059
Jaundice hepatocellular 13.63 9.97 6 307099 30 46378927
Blood lactic acid 13.63 9.97 9 307096 112 46378845
Rheumatoid nodule 13.61 9.97 24 307081 8996 46369961
Fear of eating 13.57 9.97 14 307091 336 46378621
Percutaneous coronary intervention 13.51 9.97 10 307095 151 46378806
Intermittent claudication 13.46 9.97 34 307071 1786 46377171
Therapy partial responder 13.43 9.97 7 307098 4675 46374282
Blue toe syndrome 13.41 9.97 14 307091 341 46378616
Copper metabolism disorder 13.38 9.97 4 307101 4 46378953
Biliary fibrosis 13.38 9.97 4 307101 4 46378953
Hypovolaemia 13.37 9.97 111 306994 9777 46369180
Tenosynovitis 13.25 9.97 18 307087 7497 46371460
Bladder sphincter atony 13.19 9.97 10 307095 157 46378800
Neurosensory hypoacusis 13.16 9.97 13 307092 296 46378661
Glomerular filtration rate decreased 13.10 9.97 126 306979 11568 46367389
Cardiac operation 13.10 9.97 43 307062 2623 46376334
Muscle relaxant therapy 13.10 9.97 9 307096 120 46378837
Coronary artery surgery 13.10 9.97 7 307098 57 46378900
Ovarian cyst 13.10 9.97 48 307057 14039 46364918
Internal haemorrhage 13.03 9.97 61 307044 4394 46374563
Subchondral insufficiency fracture 13.00 9.97 7 307098 58 46378899
Peripheral arterial occlusive disease 12.96 9.97 54 307051 3698 46375259
Acute left ventricular failure 12.88 9.97 21 307084 802 46378155
Rectal polyp 12.88 9.97 21 307084 802 46378155
Ecchymosis 12.88 9.97 116 306989 10460 46368497
Pneumocystis jirovecii pneumonia 12.87 9.97 54 307051 15194 46363763
Hypertensive angiopathy 12.87 9.97 8 307097 89 46378868
Hypocapnia 12.84 9.97 14 307091 359 46378598
Hypokalaemia 12.83 9.97 705 306400 87319 46291638
Wrong technique in product usage process 12.71 9.97 267 306838 54155 46324802
Lipoma 12.60 9.97 36 307069 2036 46376921
Muscle haemorrhage 12.57 9.97 49 307056 3255 46375702
Coronary artery bypass 12.53 9.97 40 307065 2405 46376552
Dysgeusia 12.51 9.97 352 306753 40139 46338818
Ventricular hypertrophy 12.49 9.97 54 307051 3760 46375197
Myoglobinaemia 12.44 9.97 5 307100 19 46378938
Soft tissue disorder 12.39 9.97 6 307099 4180 46374777
Progressive multifocal leukoencephalopathy 12.39 9.97 36 307069 11310 46367647
Atrial septal defect 12.39 9.97 14 307091 6318 46372639
Blood electrolytes abnormal 12.39 9.97 23 307082 976 46377981
Procedural hypertension 12.34 9.97 13 307092 320 46378637
Cardiac discomfort 12.34 9.97 20 307085 760 46378197
Genital haemorrhage 12.33 9.97 15 307090 6551 46372406
Nuchal rigidity 12.31 9.97 17 307088 559 46378398
Posture abnormal 12.31 9.97 37 307068 2153 46376804
Granulomatous dermatitis 12.29 9.97 8 307097 97 46378860
Erythema 12.27 9.97 792 306313 142028 46236929
Wrong dose 12.25 9.97 20 307085 765 46378192
Electrocardiogram Q wave abnormal 12.24 9.97 7 307098 66 46378891
BRASH syndrome 12.22 9.97 8 307097 98 46378859
Bronchopulmonary aspergillosis 12.19 9.97 19 307086 7477 46371480
Crohn's disease 12.16 9.97 16 307089 6755 46372202
Aspartate aminotransferase 12.15 9.97 7 307098 67 46378890
Nail bed inflammation 12.15 9.97 14 307091 382 46378575
Peripheral vascular disorder 12.12 9.97 74 307031 5903 46373054
Blood creatinine abnormal 12.10 9.97 39 307066 2357 46376600
Blood iron abnormal 12.04 9.97 3 307102 3167 46375790
Administration site discomfort 12.01 9.97 8 307097 101 46378856
Diverticulum oesophageal 11.99 9.97 9 307096 139 46378818
Duodenal ulcer 11.98 9.97 85 307020 7133 46371824
Complication of device removal 11.97 9.97 4 307101 3486 46375471
Vascular purpura 11.96 9.97 27 307078 1319 46377638
Parapsoriasis 11.95 9.97 8 307097 102 46378855
Lip swelling 11.92 9.97 234 306871 25161 46353796
Macular oedema 11.88 9.97 56 307049 4045 46374912
Incision site haemorrhage 11.87 9.97 16 307089 514 46378443
Blood calcitonin increased 11.87 9.97 5 307100 22 46378935
Exposure via ingestion 11.84 9.97 4 307101 3463 46375494
Hypophagia 11.79 9.97 264 306841 29042 46349915
Neurofibrosarcoma 11.78 9.97 9 307096 143 46378814
Tobacco abuse 11.78 9.97 18 307087 650 46378307
Aplastic anaemia 11.76 9.97 18 307087 7135 46371822
Parkinsonian rest tremor 11.75 9.97 8 307097 105 46378852
Ventricular internal diameter abnormal 11.75 9.97 6 307099 44 46378913
Diverticulum intestinal 11.75 9.97 74 307031 5967 46372990
Hypergammaglobulinaemia 11.73 9.97 15 307090 457 46378500
Gait deviation 11.72 9.97 7 307098 72 46378885
Glucose urine present 11.70 9.97 18 307087 654 46378303
Central nervous system lesion 11.64 9.97 29 307076 9586 46369371
Collagen disorder 11.60 9.97 10 307095 190 46378767
Narrow anterior chamber angle 11.53 9.97 6 307099 46 46378911
Injection site bruising 11.48 9.97 165 306940 35471 46343486
Malaise 11.43 9.97 2405 304700 328827 46050130
Fine motor skill dysfunction 11.43 9.97 5 307100 3695 46375262
Pulmonary toxicity 11.42 9.97 61 307044 4632 46374325
Macroglossia 11.41 9.97 16 307089 534 46378423
Pneumonia aspiration 11.40 9.97 143 306962 31462 46347495
Amylase increased 11.33 9.97 68 307037 5391 46373566
Jaundice cholestatic 11.32 9.97 64 307041 4965 46373992
Prevertebral soft tissue swelling of cervical space 11.32 9.97 6 307099 48 46378909
Dairy intolerance 11.32 9.97 6 307099 48 46378909
Myasthenia gravis 11.29 9.97 49 307056 3417 46375540
Colitis ischaemic 11.27 9.97 109 306996 10023 46368934
Hospitalisation 11.24 9.97 324 306781 63061 46315896
Low density lipoprotein decreased 11.22 9.97 10 307095 199 46378758
Crystal urine 11.21 9.97 6 307099 49 46378908
Alanine aminotransferase 11.21 9.97 6 307099 49 46378908
Irritability 11.19 9.97 129 306976 28817 46350140
Grip strength decreased 11.18 9.97 25 307080 8581 46370376
Autoimmune disorder 11.17 9.97 56 307049 4147 46374810
Lipohypertrophy 11.15 9.97 19 307086 753 46378204
Cardiac pacemaker insertion 11.07 9.97 51 307054 3648 46375309
Muscle fatigue 10.98 9.97 36 307069 2195 46376762
Paresis 10.97 9.97 34 307071 2012 46376945
Atrial flutter 10.97 9.97 100 307005 9048 46369909
Lymphomatoid papulosis 10.97 9.97 8 307097 118 46378839
Colitis ulcerative 10.90 9.97 70 307035 17662 46361295
Gastroduodenal haemorrhage 10.88 9.97 7 307098 83 46378874
Blood pressure systolic increased 10.86 9.97 257 306848 28530 46350427
Muscle contracture 10.85 9.97 26 307079 1321 46377636
Dysphagia 10.84 9.97 617 306488 76695 46302262
Normochromic normocytic anaemia 10.79 9.97 58 307047 4414 46374543
Muscle rupture 10.78 9.97 34 307071 2031 46376926
Chills 10.73 9.97 519 306586 95513 46283444
Blood calcium increased 10.71 9.97 86 307019 7501 46371456
N-terminal prohormone brain natriuretic peptide increased 10.67 9.97 30 307075 1681 46377276
Haemorrhagic cyst 10.66 9.97 9 307096 166 46378791
Dementia Alzheimer's type 10.65 9.97 24 307081 1171 46377786
Connective tissue inflammation 10.63 9.97 6 307099 55 46378902
Inflammation 10.62 9.97 242 306863 48539 46330418
Hepatorenal syndrome 10.59 9.97 31 307074 1777 46377180
Gait inability 10.59 9.97 305 306800 34898 46344059
Metabolic syndrome 10.58 9.97 25 307080 1259 46377698
International normalised ratio abnormal 10.55 9.97 44 307061 3015 46375942
Adverse drug reaction 10.54 9.97 217 306888 44145 46334812
Cardiac valve disease 10.53 9.97 53 307052 3931 46375026
Myeloma cast nephropathy 10.53 9.97 8 307097 126 46378831
Haematuria 10.51 9.97 241 306864 26617 46352340
Myopathy toxic 10.50 9.97 11 307094 269 46378688
Binocular eye movement disorder 10.49 9.97 5 307100 31 46378926
Bladder neoplasm 10.46 9.97 15 307090 511 46378446
Electrocardiogram QT prolonged 10.45 9.97 425 306680 50900 46328057
Urine potassium decreased 10.42 9.97 4 307101 13 46378944
Bundle branch block left 10.42 9.97 75 307030 6324 46372633
Subdural haematoma 10.40 9.97 131 306974 12866 46366091
Vertigo 10.38 9.97 430 306675 51618 46327339
Deformity 10.34 9.97 20 307085 7237 46371720
Basal ganglia haemorrhage 10.30 9.97 16 307089 586 46378371
Epilepsy 10.30 9.97 103 307002 23635 46355322
Dry eye 10.27 9.97 139 306966 30183 46348774
Schizophrenia 10.25 9.97 26 307079 8542 46370415
Microcytic anaemia 10.25 9.97 44 307061 3054 46375903
Restrictive pulmonary disease 10.24 9.97 24 307081 1202 46377755
Urinary straining 10.23 9.97 5 307100 33 46378924
Cerebral ischaemia 10.22 9.97 74 307031 6251 46372706
Drug withdrawal syndrome 10.21 9.97 123 306982 27261 46351696
Lacunar stroke 10.21 9.97 7 307098 93 46378864
Arteriosclerosis coronary artery 10.21 9.97 90 307015 8066 46370891
Alpha hydroxybutyrate dehydrogenase increased 10.20 9.97 4 307101 14 46378943
Enterococcal infection 10.18 9.97 19 307086 6968 46371989
Aggression 10.16 9.97 98 307007 22646 46356311
Lymphadenopathy 10.12 9.97 157 306948 33331 46345626
Eyelid retraction 10.11 9.97 6 307099 61 46378896
Mammogram abnormal 10.08 9.97 16 307089 597 46378360
Disorientation 10.06 9.97 316 306789 36602 46342355
Central obesity 10.04 9.97 19 307086 818 46378139
Diabetes mellitus management 10.03 9.97 3 307102 3 46378954
Fungal disease carrier 10.03 9.97 3 307102 3 46378954
Autoimmune encephalopathy 10.03 9.97 3 307102 3 46378954
Fructosamine increased 10.03 9.97 3 307102 3 46378954
Vitrectomy 10.02 9.97 8 307097 136 46378821
Iron deficiency anaemia 10.01 9.97 164 306941 17042 46361915
Mandibular mass 9.98 9.97 9 307096 182 46378775

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1316.21 11.22 2606 303266 74061 29572545
Immune-mediated myositis 932.62 11.22 386 305486 899 29645707
Rhabdomyolysis 773.73 11.22 1883 303989 61697 29584909
Drug abuse 472.30 11.22 127 305745 81945 29564661
Toxicity to various agents 469.93 11.22 676 305196 176507 29470099
Blood creatine phosphokinase increased 460.66 11.22 1229 304643 42619 29603987
Myopathy 345.36 11.22 481 305391 10105 29636501
Febrile neutropenia 315.41 11.22 375 305497 106318 29540288
Foetal exposure during pregnancy 304.00 11.22 18 305854 36853 29609753
Myocardial infarction 285.65 11.22 2227 303645 123398 29523208
Off label use 279.87 11.22 1453 304419 247837 29398769
Necrotising myositis 266.09 11.22 114 305758 299 29646307
Completed suicide 256.12 11.22 387 305485 99105 29547501
Drug hypersensitivity 231.06 11.22 1340 304532 67179 29579427
Neutropenia 214.37 11.22 639 305233 127901 29518705
Pyrexia 210.90 11.22 1958 303914 292531 29354075
Coronary artery disease 204.01 11.22 1026 304846 48686 29597920
Acute myocardial infarction 181.47 11.22 1040 304832 51899 29594707
Drug ineffective 180.07 11.22 2424 303448 337963 29308643
Death 172.19 11.22 2592 303280 354691 29291915
Cerebrovascular accident 164.31 11.22 1433 304439 82044 29564562
Angina pectoris 151.11 11.22 650 305222 28868 29617738
Chest pain 147.39 11.22 1842 304030 115785 29530821
Blood cholesterol increased 147.14 11.22 444 305428 16526 29630080
Muscular weakness 144.76 11.22 1129 304743 62516 29584090
Acute kidney injury 131.20 11.22 3691 302181 270151 29376455
Dizziness 125.81 11.22 2736 303136 192173 29454433
Low density lipoprotein increased 125.81 11.22 179 305693 3837 29642769
Premature baby 124.03 11.22 13 305859 16678 29629928
Polymyositis 118.35 11.22 106 305766 1330 29645276
Muscle spasms 115.77 11.22 1090 304782 63748 29582858
High density lipoprotein decreased 113.98 11.22 152 305720 3058 29643548
Bone marrow failure 108.35 11.22 87 305785 29698 29616908
Pneumonia 105.53 11.22 2605 303267 331701 29314905
Muscle rupture 105.41 11.22 119 305753 2002 29644604
Coronary artery occlusion 104.44 11.22 300 305572 10857 29635749
Malignant neoplasm progression 103.43 11.22 384 305488 71903 29574703
Cytomegalovirus infection 102.45 11.22 57 305815 23617 29622989
Acute coronary syndrome 101.08 11.22 337 305535 13236 29633370
Mucosal inflammation 100.18 11.22 98 305774 30396 29616210
White blood cell count decreased 99.70 11.22 479 305393 83468 29563138
Treatment failure 99.05 11.22 125 305747 34554 29612052
Transient ischaemic attack 99.05 11.22 514 305358 24686 29621920
Drug resistance 98.54 11.22 41 305831 20092 29626514
Platelet count decreased 98.23 11.22 657 305215 105472 29541134
Overdose 95.12 11.22 490 305382 83847 29562759
Coronary artery stenosis 93.89 11.22 253 305619 8817 29637789
Pancytopenia 93.77 11.22 498 305374 84554 29562052
Angina unstable 90.21 11.22 304 305568 12006 29634600
Graft versus host disease 90.04 11.22 3 305869 10147 29636459
Leukopenia 88.64 11.22 286 305586 55873 29590733
Ischaemic stroke 83.74 11.22 359 305513 15916 29630690
Drug interaction 81.86 11.22 2640 303232 196928 29449678
Product use in unapproved indication 80.94 11.22 432 305440 73261 29573345
Drug dependence 80.24 11.22 60 305812 21235 29625371
Tendon rupture 80.23 11.22 204 305668 6860 29639746
Suicide attempt 75.29 11.22 164 305708 36533 29610073
Sepsis 75.03 11.22 1048 304824 145347 29501259
Stomatitis 74.52 11.22 169 305703 37110 29609496
Neutrophil count decreased 74.34 11.22 206 305666 42248 29604358
Myositis 73.18 11.22 253 305619 10124 29636482
Exposure during pregnancy 72.04 11.22 6 305866 9255 29637351
Vascular stent thrombosis 71.29 11.22 103 305769 2240 29644366
Dyspnoea 69.72 11.22 4111 301761 329184 29317422
Muscle disorder 69.54 11.22 102 305770 2250 29644356
Respiratory arrest 69.37 11.22 120 305752 29138 29617468
Amnesia 68.89 11.22 455 305417 23866 29622740
Thrombocytopenia 67.76 11.22 988 304884 136056 29510550
Blood triglycerides increased 65.17 11.22 300 305572 13717 29632889
Intentional overdose 64.93 11.22 212 305660 41269 29605337
Pneumocystis jirovecii pneumonia 64.81 11.22 48 305824 17072 29629534
Low density lipoprotein decreased 64.71 11.22 64 305808 917 29645689
Disseminated intravascular coagulation 64.27 11.22 79 305793 22092 29624514
Aspergillus infection 64.25 11.22 13 305859 10201 29636405
Muscle atrophy 60.92 11.22 177 305695 6447 29640159
Bronchopulmonary aspergillosis 60.14 11.22 25 305847 12259 29634347
Syncope 59.85 11.22 1208 304664 83695 29562911
Hepatitis C 59.78 11.22 30 305842 13175 29633431
Erectile dysfunction 59.61 11.22 352 305520 17750 29628856
Disease progression 59.49 11.22 525 305347 79349 29567257
Pain in extremity 59.19 11.22 1509 304363 108712 29537894
Immune reconstitution inflammatory syndrome 58.48 11.22 11 305861 9090 29637516
Product substitution issue 58.45 11.22 230 305642 9805 29636801
Amyotrophic lateral sclerosis 55.67 11.22 60 305812 956 29645650
Product monitoring error 55.12 11.22 78 305794 1663 29644943
Plasma cell myeloma 55.09 11.22 320 305552 53142 29593464
Muscle injury 54.54 11.22 65 305807 1162 29645444
Rectal haemorrhage 54.37 11.22 571 305301 34368 29612238
Muscle necrosis 53.30 11.22 52 305820 732 29645874
Intentional self-injury 52.45 11.22 37 305835 13495 29633111
Intentional product misuse 52.32 11.22 180 305692 34487 29612119
Pathogen resistance 52.29 11.22 11 305861 8399 29638207
Respiratory depression 52.27 11.22 26 305846 11477 29635129
Autoimmune myositis 51.58 11.22 17 305855 13 29646593
Poisoning 51.31 11.22 26 305846 11356 29635250
Atrial fibrillation 50.83 11.22 1455 304417 106669 29539937
Labelled drug-drug interaction medication error 50.82 11.22 228 305644 10310 29636296
Lactic acidosis 50.41 11.22 514 305358 30699 29615907
Haematuria 50.13 11.22 688 305184 44146 29602460
Rheumatoid arthritis 50.08 11.22 233 305639 40964 29605642
Respiratory failure 49.91 11.22 725 305147 99917 29546689
Infusion related reaction 49.56 11.22 229 305643 40335 29606271
Melaena 49.48 11.22 528 305344 31909 29614697
Ascites 48.65 11.22 195 305677 35726 29610880
Mitral valve incompetence 48.62 11.22 265 305607 12969 29633637
Septic shock 47.38 11.22 418 305454 63189 29583417
Product use issue 47.10 11.22 276 305596 45740 29600866
Myocardial ischaemia 46.66 11.22 320 305552 16997 29629609
Infection 46.60 11.22 541 305331 77533 29569073
Neurotoxicity 46.09 11.22 40 305832 13142 29633464
Asthenia 46.01 11.22 2729 303143 218561 29428045
Hypertensive emergency 44.78 11.22 49 305823 795 29645811
Upper gastrointestinal haemorrhage 44.75 11.22 381 305491 21647 29624959
Chromaturia 44.62 11.22 268 305604 13597 29633009
Blood glucose increased 44.53 11.22 879 304993 60651 29585955
Low birth weight baby 44.46 11.22 5 305867 6071 29640535
Type 2 diabetes mellitus 44.28 11.22 264 305608 13358 29633248
Muscle enzyme increased 44.19 11.22 28 305844 198 29646408
Dyspnoea exertional 43.90 11.22 554 305318 34876 29611730
Hypoglycaemia 43.41 11.22 747 305125 50234 29596372
Hepatocellular carcinoma 43.25 11.22 22 305850 9588 29637018
Product prescribing error 43.20 11.22 306 305566 16427 29630179
Presyncope 42.85 11.22 296 305576 15760 29630846
Bradycardia 42.79 11.22 922 304950 64604 29582002
Myopathy toxic 42.48 11.22 35 305837 389 29646217
Cardio-respiratory arrest 42.06 11.22 378 305494 56928 29589678
Intentional product use issue 42.02 11.22 210 305662 36230 29610376
Acute myeloid leukaemia 41.64 11.22 75 305797 17931 29628675
Myocardial necrosis marker increased 40.91 11.22 64 305808 1497 29645109
Exercise lack of 40.90 11.22 20 305852 78 29646528
Posterior reversible encephalopathy syndrome 40.60 11.22 19 305853 8688 29637918
Faeces discoloured 40.15 11.22 262 305610 13684 29632922
Seizure 40.01 11.22 736 305136 97739 29548867
Epstein-Barr virus infection 39.25 11.22 10 305862 6696 29639910
Liver function test abnormal 39.22 11.22 486 305386 30464 29616142
Serotonin syndrome 39.19 11.22 77 305795 17814 29628792
Hypomagnesaemia 39.11 11.22 297 305575 16301 29630305
Progressive multifocal leukoencephalopathy 38.56 11.22 22 305850 8991 29637615
Tendonitis 38.10 11.22 173 305699 7863 29638743
Hepatic encephalopathy 37.63 11.22 54 305818 14138 29632468
Glycosylated haemoglobin increased 37.57 11.22 194 305678 9297 29637309
Low density lipoprotein abnormal 36.83 11.22 27 305845 249 29646357
Blood cholesterol decreased 36.51 11.22 47 305825 912 29645694
Haemophagocytic lymphohistiocytosis 36.35 11.22 28 305844 9763 29636843
Hepatitis cholestatic 36.23 11.22 168 305704 7704 29638902
Arteriosclerosis 35.89 11.22 211 305661 10622 29635984
Hepatocellular injury 35.81 11.22 408 305464 25063 29621543
Ischaemic cardiomyopathy 35.60 11.22 143 305729 6154 29640452
Atrial septal defect 35.54 11.22 12 305860 6689 29639917
C-reactive protein abnormal 35.43 11.22 7 305865 5586 29641020
Tumour lysis syndrome 35.19 11.22 48 305824 12837 29633769
Multiple organ dysfunction syndrome 35.18 11.22 447 305425 63040 29583566
Post transplant lymphoproliferative disorder 34.98 11.22 6 305866 5300 29641306
Cystitis haemorrhagic 34.88 11.22 4 305868 4783 29641823
Agitation 34.50 11.22 369 305503 53704 29592902
Dermatomyositis 34.32 11.22 48 305824 1012 29645594
Muscle fatigue 34.27 11.22 51 305821 1140 29645466
Cardiac disorder 34.12 11.22 585 305287 39308 29607298
Cardiotoxicity 33.95 11.22 3 305869 4411 29642195
Vascular stent stenosis 33.83 11.22 48 305824 1026 29645580
Cytokine release syndrome 33.70 11.22 31 305841 9902 29636704
Restlessness 33.65 11.22 118 305754 22481 29624125
Peritonitis 33.61 11.22 109 305763 21266 29625340
Hyperkalaemia 33.44 11.22 897 304975 65113 29581493
Stent placement 33.23 11.22 113 305759 4483 29642123
Stenosis 33.21 11.22 37 305835 613 29645993
Coma 33.21 11.22 259 305613 40190 29606416
Arteriosclerosis coronary artery 32.81 11.22 211 305661 10965 29635641
Maternal drugs affecting foetus 32.61 11.22 3 305869 4270 29642336
Drug withdrawal syndrome 32.56 11.22 99 305773 19710 29626896
Haematoma 32.48 11.22 381 305491 23572 29623034
Abnormal behaviour 32.28 11.22 143 305729 25480 29621126
Diabetic ketoacidosis 32.21 11.22 276 305596 15710 29630896
Ventricular hypokinesia 31.57 11.22 105 305767 4118 29642488
Orthostatic hypotension 31.01 11.22 378 305494 23601 29623005
Depressed level of consciousness 30.79 11.22 246 305626 37976 29608630
Myelodysplastic syndrome 30.76 11.22 94 305778 18684 29627922
Bacteraemia 30.71 11.22 71 305801 15489 29631117
Substance abuse 30.38 11.22 17 305855 7023 29639583
Pancreatitis acute 30.23 11.22 398 305474 25297 29621309
Neonatal respiratory distress syndrome 30.13 11.22 3 305869 4009 29642597
Hypercholesterolaemia 29.92 11.22 155 305717 7437 29639169
Diabetes mellitus inadequate control 29.87 11.22 228 305644 12534 29634072
Blood loss anaemia 29.56 11.22 155 305717 7472 29639134
Blood cholesterol abnormal 29.56 11.22 51 305821 1297 29645309
Blood creatine phosphokinase MB increased 29.34 11.22 63 305809 1893 29644713
Tricuspid valve incompetence 29.24 11.22 169 305703 8454 29638152
Coronary artery restenosis 28.93 11.22 47 305825 1136 29645470
Polymyalgia rheumatica 28.90 11.22 45 305827 1048 29645558
Cardiac failure congestive 28.85 11.22 1094 304778 83313 29563293
Swollen tongue 28.84 11.22 232 305640 12960 29633646
Neuroleptic malignant syndrome 28.56 11.22 79 305793 16216 29630390
Tachycardia 28.44 11.22 556 305316 73183 29573423
Myoglobin blood increased 28.35 11.22 59 305813 1734 29644872
Vomiting 28.31 11.22 1899 303973 217919 29428687
Nocturia 28.25 11.22 163 305709 8149 29638457
Carotid artery stenosis 28.18 11.22 108 305764 4546 29642060
International normalised ratio increased 28.10 11.22 662 305210 47077 29599529
Intermittent claudication 28.00 11.22 67 305805 2167 29644439
Glycogen storage disease type V 27.87 11.22 12 305860 32 29646574
Febrile bone marrow aplasia 27.79 11.22 25 305847 8072 29638534
Psychotic disorder 27.76 11.22 119 305753 21396 29625210
Hypoalbuminaemia 27.67 11.22 44 305828 11048 29635558
Therapeutic product effect incomplete 27.61 11.22 217 305655 33617 29612989
Neoplasm progression 27.58 11.22 93 305779 17930 29628676
Coronary artery bypass 27.43 11.22 115 305757 5047 29641559
Myelosuppression 27.11 11.22 21 305851 7301 29639305
Cerebral haemorrhage 26.95 11.22 479 305393 32408 29614198
Fall 26.56 11.22 2179 303693 179693 29466913
Quadriparesis 26.34 11.22 42 305830 999 29645607
Lip swelling 26.18 11.22 221 305651 12523 29634083
Ocular myasthenia 26.10 11.22 21 305851 225 29646381
Cytomegalovirus viraemia 25.95 11.22 13 305859 5716 29640890
Pericardial haemorrhage 25.90 11.22 77 305795 2841 29643765
Akathisia 25.85 11.22 14 305858 5890 29640716
Balance disorder 25.28 11.22 518 305354 35975 29610631
Haemorrhagic stroke 25.27 11.22 127 305745 6020 29640586
Cardiac failure 25.21 11.22 1067 304805 82351 29564255
Oedema peripheral 24.81 11.22 1320 304552 104512 29542094
Gastrointestinal haemorrhage 24.69 11.22 1065 304807 82381 29564225
Pruritus genital 24.53 11.22 27 305845 441 29646165
Lipids abnormal 24.26 11.22 24 305848 344 29646262
Lymphocyte count decreased 24.21 11.22 106 305766 18949 29627657
Enterococcal infection 24.15 11.22 29 305843 8195 29638411
Troponin increased 24.05 11.22 164 305708 8693 29637913
Hepatic enzyme increased 24.05 11.22 478 305394 33016 29613590
Haemorrhage intracranial 24.01 11.22 247 305625 14785 29631821
Ileus 23.98 11.22 80 305792 15475 29631131
Thrombocytopenic purpura 23.92 11.22 41 305831 1037 29645569
Aggression 23.89 11.22 251 305621 36656 29609950
Glomerular filtration rate decreased 23.86 11.22 198 305674 11164 29635442
Encephalopathy 23.81 11.22 212 305660 31993 29614613
Genital swelling 23.81 11.22 14 305858 85 29646521
Palpitations 23.73 11.22 478 305394 33095 29613511
Electrocardiogram ST segment depression 23.56 11.22 65 305807 2297 29644309
Abnormal weight gain 23.51 11.22 37 305835 870 29645736
Acute respiratory distress syndrome 23.37 11.22 142 305730 23330 29623276
Diabetic nephropathy 23.37 11.22 56 305816 1813 29644793
Muscle strain 23.36 11.22 87 305785 3612 29642994
Acquired haemophilia 23.08 11.22 34 305838 753 29645853
Drug use disorder 22.96 11.22 3 305869 3245 29643361
Diffuse large B-cell lymphoma 22.66 11.22 28 305844 7813 29638793
Obstructive pancreatitis 22.63 11.22 24 305848 375 29646231
Haematotoxicity 22.46 11.22 18 305854 6152 29640454
Essential hypertension 22.42 11.22 66 305806 2422 29644184
Type IIa hyperlipidaemia 22.40 11.22 12 305860 59 29646547
Heart rate irregular 22.30 11.22 207 305665 12052 29634554
Status epilepticus 22.28 11.22 50 305822 11022 29635584
Maternal exposure during pregnancy 22.22 11.22 6 305866 3865 29642741
Osteonecrosis 22.22 11.22 87 305785 16048 29630558
Lymphadenopathy 21.96 11.22 152 305720 24224 29622382
Musculoskeletal pain 21.70 11.22 440 305432 30500 29616106
Candida infection 21.69 11.22 82 305790 15280 29631326
Hyperbilirubinaemia 21.68 11.22 94 305778 16848 29629758
Blood cholesterol 21.54 11.22 14 305858 104 29646502
Carotid artery occlusion 21.48 11.22 57 305815 1968 29644638
Device related infection 21.41 11.22 95 305777 16920 29629686
Hepatojugular reflux 21.30 11.22 22 305850 333 29646273
Osteonecrosis of jaw 21.06 11.22 108 305764 18510 29628096
Hyperlipidaemia 21.03 11.22 226 305646 13681 29632925
Cerebral infarction 20.86 11.22 382 305490 25991 29620615
Therapy partial responder 20.67 11.22 6 305866 3685 29642921
Carotid artery disease 20.61 11.22 36 305836 925 29645681
Oropharyngeal pain 20.45 11.22 189 305683 28307 29618299
Ejection fraction decreased 20.40 11.22 241 305631 14934 29631672
Plantar fasciitis 20.32 11.22 35 305837 889 29645717
Hyperammonaemia 20.22 11.22 16 305856 5504 29641102
Peripheral vascular disorder 20.18 11.22 106 305766 5113 29641493
Arterial stenosis 20.18 11.22 41 305831 1184 29645422
Oxygen saturation decreased 20.11 11.22 317 305555 43123 29603483
Transient global amnesia 20.01 11.22 21 305851 324 29646282
Palmar-plantar erythrodysaesthesia syndrome 19.96 11.22 81 305791 14789 29631817
Sinusitis 19.90 11.22 231 305641 33114 29613492
Abdominal pain 19.84 11.22 1158 304714 134496 29512110
Transplant rejection 19.83 11.22 40 305832 9166 29637440
Pseudomonas infection 19.76 11.22 49 305823 10433 29636173
Vitreous detachment 19.71 11.22 32 305840 773 29645833
Fungal infection 19.59 11.22 72 305800 13528 29633078
Gout 19.46 11.22 266 305606 17049 29629557
Gynaecomastia 19.43 11.22 149 305723 8202 29638404
Apparent death 19.39 11.22 6 305866 3536 29643070
Inclusion body myositis 19.16 11.22 6 305866 3 29646603
Hepatitis acute 19.14 11.22 131 305741 6952 29639654
Peripheral ischaemia 19.05 11.22 106 305766 5228 29641378
Alcohol abuse 19.01 11.22 16 305856 5337 29641269
Colitis 18.98 11.22 212 305660 30608 29615998
Pneumonia cytomegaloviral 18.79 11.22 3 305869 2793 29643813
Penile haemorrhage 18.73 11.22 27 305845 586 29646020
Dystonia 18.71 11.22 45 305827 9682 29636924
Nocardiosis 18.65 11.22 6 305866 3449 29643157
Oscillopsia 18.62 11.22 9 305863 34 29646572
Cytopenia 18.54 11.22 35 305837 8221 29638385
Cytomegalovirus test positive 18.53 11.22 7 305865 3638 29642968
Memory impairment 18.48 11.22 504 305368 36670 29609936
Drug abuser 18.46 11.22 11 305861 4390 29642216
Condition aggravated 18.39 11.22 1187 304685 136679 29509927
Brain oedema 18.28 11.22 65 305807 12333 29634273
Peripheral paralysis 18.23 11.22 9 305863 36 29646570
Herbal interaction 18.20 11.22 20 305852 326 29646280
Blood triglycerides decreased 18.08 11.22 10 305862 53 29646553
Autoimmune disorder 18.06 11.22 45 305827 1494 29645112
Mycobacterium avium complex infection 18.02 11.22 3 305869 2708 29643898
Blood urea abnormal 18.02 11.22 28 305844 651 29645955
Shock 18.00 11.22 148 305724 22711 29623895
Pruritus 18.00 11.22 1421 304451 116783 29529823
Haematoma muscle 17.98 11.22 26 305846 566 29646040
Penis injury 17.96 11.22 17 305855 230 29646376
Vertigo 17.95 11.22 328 305544 22307 29624299
Respiratory distress 17.94 11.22 233 305639 32739 29613867
Suicidal ideation 17.93 11.22 260 305612 35854 29610752
Fibrous histiocytoma 17.72 11.22 13 305859 120 29646486
Aortic aneurysm 17.57 11.22 119 305753 6294 29640312
Avoidant personality disorder 17.47 11.22 6 305866 6 29646600
Occupational problem environmental 17.47 11.22 6 305866 6 29646600
Cardiac failure chronic 17.40 11.22 111 305761 5752 29640854
Chest discomfort 17.37 11.22 597 305275 44883 29601723
Impatience 17.29 11.22 18 305854 275 29646331
Epilepsy 17.09 11.22 128 305744 20041 29626565
Blood creatine phosphokinase abnormal 17.08 11.22 15 305857 183 29646423
Pneumonia aspiration 17.05 11.22 277 305595 37503 29609103
Non-cardiac chest pain 17.02 11.22 85 305787 4019 29642587
Cerebral haematoma 16.99 11.22 91 305781 4423 29642183
Aldolase increased 16.97 11.22 10 305862 61 29646545
Hepatic failure 16.93 11.22 245 305627 33798 29612808
Venoocclusive disease 16.92 11.22 3 305869 2587 29644019
Dyskinesia 16.91 11.22 142 305730 21692 29624914
Lipids increased 16.88 11.22 33 305839 926 29645680
Crohn's disease 16.73 11.22 12 305860 4340 29642266
Synovitis 16.72 11.22 48 305824 9735 29636871
Neutropenic sepsis 16.70 11.22 60 305812 11349 29635257
Adrenal insufficiency 16.69 11.22 53 305819 10410 29636196
Shock haemorrhagic 16.67 11.22 164 305708 9701 29636905
Blood immunoglobulin E increased 16.66 11.22 47 305825 1683 29644923
Muscle discomfort 16.60 11.22 8 305864 30 29646576
Toxic epidermal necrolysis 16.59 11.22 111 305761 17829 29628777
Splenomegaly 16.52 11.22 76 305796 13404 29633202
Vascular graft 16.50 11.22 42 305830 1413 29645193
Accidental exposure to product 16.31 11.22 51 305821 10064 29636542
Atrial flutter 16.30 11.22 220 305652 14061 29632545
Product odour abnormal 16.28 11.22 25 305847 575 29646031
Benign pancreatic neoplasm 16.16 11.22 6 305866 9 29646597
Altered state of consciousness 16.13 11.22 128 305744 19791 29626815
Pulmonary valve incompetence 16.12 11.22 27 305845 670 29645936
Spinal stenosis 16.11 11.22 87 305785 4242 29642364
Disease recurrence 16.10 11.22 82 305790 14079 29632527
Lipoprotein (a) increased 16.08 11.22 9 305863 49 29646557
Somnolence 16.00 11.22 816 305056 95947 29550659
Anticoagulation drug level increased 15.99 11.22 23 305849 498 29646108
Clostridium difficile infection 15.96 11.22 95 305777 15688 29630918
Staphylococcal infection 15.93 11.22 215 305657 30009 29616597
Benign prostatic hyperplasia 15.90 11.22 170 305702 10277 29636329
Blood pressure inadequately controlled 15.86 11.22 60 305812 2510 29644096
Diabetes mellitus 15.85 11.22 549 305323 41316 29605290
Delirium 15.76 11.22 306 305566 40325 29606281
Pneumonia fungal 15.73 11.22 20 305852 5513 29641093
Ageusia 15.70 11.22 150 305722 8803 29637803
Blood glucose decreased 15.69 11.22 203 305669 12850 29633756
Iliac artery stenosis 15.68 11.22 11 305861 94 29646512
Bilirubin conjugated abnormal 15.67 11.22 12 305860 119 29646487
Cholestasis 15.61 11.22 349 305523 24601 29622005
Subarachnoid haemorrhage 15.57 11.22 162 305710 9724 29636882
Mastitis 15.54 11.22 14 305858 177 29646429
Gamma-glutamyltransferase abnormal 15.50 11.22 16 305856 242 29646364
Pulmonary haemorrhage 15.39 11.22 47 305825 9345 29637261
Myasthenia gravis 15.39 11.22 66 305806 2926 29643680
Left atrial dilatation 15.33 11.22 47 305825 1764 29644842
Sopor 15.30 11.22 59 305813 10932 29635674
Scrotal pain 15.30 11.22 29 305843 795 29645811
Toe amputation 15.25 11.22 54 305818 2187 29644419
Hepatitis B 15.23 11.22 24 305848 6048 29640558
Pleural effusion 15.21 11.22 610 305262 73456 29573150
Violence-related symptom 15.14 11.22 23 305849 524 29646082
Cardiogenic shock 15.05 11.22 249 305623 16612 29629994
Muscle contractions involuntary 15.00 11.22 46 305826 1727 29644879
Hypocalcaemia 14.99 11.22 304 305568 21072 29625534
Foetal growth restriction 14.98 11.22 9 305863 3576 29643030
Deep vein thrombosis 14.98 11.22 487 305385 60014 29586592
Alcohol poisoning 14.97 11.22 10 305862 3754 29642852
Autoimmune hepatitis 14.96 11.22 75 305797 3552 29643054
Thrombotic microangiopathy 14.90 11.22 42 305830 8568 29638038
Liver transplant 14.89 11.22 5 305867 2797 29643809
Hemianaesthesia 14.89 11.22 10 305862 79 29646527
Lipodystrophy acquired 14.79 11.22 9 305863 3551 29643055
Diaphragm muscle weakness 14.79 11.22 10 305862 80 29646526
Failure to suspend medication 14.79 11.22 10 305862 80 29646526
Skin discomfort 14.78 11.22 7 305865 25 29646581
Generalised tonic-clonic seizure 14.76 11.22 128 305744 19423 29627183
Discoloured vomit 14.67 11.22 19 305853 371 29646235
Drug screen positive 14.66 11.22 14 305858 4393 29642213
Withdrawal syndrome 14.65 11.22 62 305810 11188 29635418
Peripheral artery occlusion 14.63 11.22 40 305832 1406 29645200
Epicondylitis 14.61 11.22 20 305852 413 29646193
Systemic candida 14.57 11.22 5 305867 2759 29643847
Weight decreased 14.53 11.22 1757 304115 149164 29497442
Lymph node calcification 14.52 11.22 14 305858 194 29646412
Staphylococcal sepsis 14.50 11.22 49 305823 9442 29637164
Product administered to patient of inappropriate age 14.49 11.22 4 305868 2539 29644067
Portal hypertension 14.48 11.22 11 305861 3862 29642744
Peripheral artery stenosis 14.43 11.22 29 305843 831 29645775
Cells in urine 14.38 11.22 4 305868 0 29646606
Immunology test abnormal 14.38 11.22 4 305868 0 29646606
Arterial repair 14.38 11.22 4 305868 0 29646606
Bacterial infection 14.34 11.22 73 305799 12537 29634069
Electrocardiogram ST-T change 14.31 11.22 24 305848 596 29646010
Nipple pain 14.26 11.22 24 305848 598 29646008
Paraesthesia 14.24 11.22 685 305187 53642 29592964
Arterial occlusive disease 14.24 11.22 80 305792 3960 29642646
Neuromyopathy 14.23 11.22 31 305841 941 29645665
AST/ALT ratio abnormal 14.20 11.22 6 305866 15 29646591
Radiculitis brachial 14.20 11.22 6 305866 15 29646591
Product contamination physical 14.18 11.22 7 305865 28 29646578
Congenital diaphragmatic anomaly 14.18 11.22 7 305865 28 29646578
Periodontitis 14.17 11.22 44 305828 1663 29644943
Cystic fibrosis 14.08 11.22 3 305869 2271 29644335
Cardiac arrest 14.04 11.22 790 305082 92060 29554546
Diastolic dysfunction 14.02 11.22 83 305789 4188 29642418
Conjunctival hyperaemia 14.02 11.22 3 305869 2264 29644342
Peripheral coldness 13.97 11.22 115 305757 6468 29640138
Laryngeal haematoma 13.97 11.22 11 305861 114 29646492
On and off phenomenon 13.96 11.22 6 305866 2885 29643721
Clonus 13.95 11.22 4 305868 2477 29644129
Wound haematoma 13.94 11.22 9 305863 66 29646540
Mydriasis 13.83 11.22 26 305846 6117 29640489
Sedation 13.83 11.22 104 305768 16269 29630337
Nightmare 13.77 11.22 186 305686 11890 29634716
Cardiac ablation 13.75 11.22 23 305849 570 29646036
Urticaria chronic 13.75 11.22 10 305862 91 29646515
Paradoxical drug reaction 13.72 11.22 5 305867 2657 29643949
Sinonasal obstruction 13.68 11.22 6 305866 17 29646589
Lower gastrointestinal haemorrhage 13.65 11.22 132 305740 7772 29638834
Aortic arteriosclerosis 13.64 11.22 78 305794 3886 29642720
Cardiac failure acute 13.62 11.22 149 305723 9060 29637546
Cardiac valve disease 13.62 11.22 63 305809 2886 29643720
Pneumothorax 13.61 11.22 103 305769 16090 29630516
Ventricular hypertrophy 13.57 11.22 91 305781 4796 29641810
Microcytic anaemia 13.57 11.22 51 305821 2127 29644479
Vascular graft occlusion 13.55 11.22 23 305849 577 29646029
Mixed liver injury 13.54 11.22 48 305824 1945 29644661
Lipid metabolism disorder 13.53 11.22 15 305857 247 29646359
Drug ineffective for unapproved indication 13.53 11.22 61 305811 10819 29635787
Angiocardiogram 13.50 11.22 13 305859 180 29646426
Cold sweat 13.46 11.22 147 305725 8935 29637671
Central obesity 13.42 11.22 22 305850 536 29646070
Carcinoid tumour of the gastrointestinal tract 13.42 11.22 8 305864 50 29646556
Enteritis 13.37 11.22 30 305842 6615 29639991
Aortic valve replacement 13.37 11.22 25 305847 678 29645928
Herpes zoster 13.36 11.22 220 305652 29723 29616883
Hypernatraemia 13.33 11.22 36 305836 7448 29639158
Incorrect route of product administration 13.16 11.22 65 305807 11250 29635356
Klebsiella infection 13.13 11.22 32 305840 6855 29639751
Hypertransaminasaemia 13.08 11.22 76 305796 3809 29642797
Spur cell anaemia 13.05 11.22 8 305864 53 29646553
Blood pressure increased 13.04 11.22 877 304995 71051 29575555
Nephropathy toxic 13.02 11.22 60 305812 10579 29636027
Atrioventricular block second degree 13.00 11.22 65 305807 3075 29643531
Ventricular dyskinesia 12.94 11.22 12 305860 158 29646448
Catheter site haematoma 12.94 11.22 12 305860 158 29646448
Spermatozoa abnormal 12.93 11.22 8 305864 54 29646552
Hepatic cirrhosis 12.87 11.22 103 305769 15896 29630710
Lacunar infarction 12.84 11.22 65 305807 3090 29643516
Tuberculosis 12.83 11.22 41 305831 8036 29638570
Cardiac stress test abnormal 12.82 11.22 17 305855 340 29646266
Stem cell transplant 12.82 11.22 3 305869 2128 29644478
Haematochezia 12.76 11.22 448 305424 33774 29612832
Hypercalcaemia 12.75 11.22 75 305797 12420 29634186
Intraventricular haemorrhage 12.74 11.22 63 305809 2967 29643639
Hypotension 12.63 11.22 2279 303593 198286 29448320
Hyponatraemic syndrome 12.61 11.22 14 305858 231 29646375
Pelvic mass 12.61 11.22 11 305861 133 29646473
Mean cell volume abnormal 12.59 11.22 15 305857 268 29646338
Post micturition dribble 12.58 11.22 5 305867 10 29646596
Blood glucose fluctuation 12.58 11.22 72 305800 3589 29643017
Thrombosis in device 12.54 11.22 70 305802 3456 29643150
Angioedema 12.54 11.22 449 305423 33935 29612671
Therapeutic product effect decreased 12.52 11.22 215 305657 28861 29617745
Cyanosis 12.52 11.22 71 305801 11864 29634742
C-reactive protein increased 12.48 11.22 343 305529 43130 29603476
Exercise tolerance decreased 12.46 11.22 74 305798 3738 29642868
Acute lymphocytic leukaemia 12.44 11.22 8 305864 3064 29643542
Personality change 12.39 11.22 85 305787 4515 29642091
Eructation 12.28 11.22 69 305803 3415 29643191
Blood alkaline phosphatase abnormal 12.28 11.22 19 305853 440 29646166
Metastases to central nervous system 12.26 11.22 36 305836 7248 29639358
Muscle haemorrhage 12.18 11.22 72 305800 3631 29642975
Urinary occult blood positive 12.17 11.22 4 305868 3 29646603
Mouth swelling 12.17 11.22 40 305832 1559 29645047
Brain stem haematoma 12.16 11.22 11 305861 140 29646466
Tachypnoea 12.15 11.22 96 305776 14856 29631750
Basal ganglia haemorrhage 12.04 11.22 27 305845 836 29645770
Miosis 11.98 11.22 40 305832 7736 29638870
Oesophageal pain 11.96 11.22 25 305847 737 29645869
Paratracheal lymphadenopathy 11.93 11.22 9 305863 87 29646519
Pseudohyponatraemia 11.93 11.22 9 305863 87 29646519
Coronary artery surgery 11.93 11.22 10 305862 114 29646492
Hypoxia 11.89 11.22 385 305487 47469 29599137
Dilatation atrial 11.88 11.22 48 305824 2071 29644535
Therapeutic response decreased 11.84 11.22 176 305696 24173 29622433
Anal abscess 11.82 11.22 21 305851 5048 29641558
Drug titration error 11.82 11.22 18 305854 411 29646195
Duodenal ulcer haemorrhage 11.80 11.22 85 305787 4587 29642019
Drug level increased 11.80 11.22 125 305747 18229 29628377
Atrioventricular block 11.79 11.22 120 305752 7162 29639444
Second primary malignancy 11.76 11.22 30 305842 6326 29640280
Gastrooesophageal reflux disease 11.71 11.22 421 305451 31834 29614772
Smooth muscle antibody positive 11.70 11.22 5 305867 13 29646593
Antiphospholipid antibodies 11.70 11.22 5 305867 13 29646593
Sinus bradycardia 11.68 11.22 176 305696 11519 29635087
Corneal abrasion 11.67 11.22 14 305858 252 29646354
Gait inability 11.62 11.22 263 305609 18578 29628028
Motor neurone disease 11.59 11.22 13 305859 217 29646389
Large intestine polyp 11.56 11.22 112 305760 6597 29640009
Asthma 11.55 11.22 281 305591 35893 29610713
Liver transplant rejection 11.55 11.22 4 305868 2194 29644412
Aortic valve incompetence 11.54 11.22 88 305784 4835 29641771
Psychomotor hyperactivity 11.54 11.22 44 305828 8180 29638426
Dyspnoea at rest 11.54 11.22 55 305817 2551 29644055
Injection site pain 11.53 11.22 229 305643 30081 29616525
Urethral cancer 11.45 11.22 6 305866 28 29646578
Hypovolaemic shock 11.44 11.22 109 305763 6391 29640215
Eye laser surgery 11.44 11.22 5 305867 14 29646592
Pulmonary tuberculosis 11.44 11.22 20 305852 4837 29641769
Small intestinal obstruction 11.42 11.22 87 305785 13572 29633034
Ammonia increased 11.38 11.22 16 305856 4225 29642381
Therapy non-responder 11.37 11.22 222 305650 29231 29617375

Pharmacologic Action:

SourceCodeDescription
ATC C10AA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX15 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Slow Progression of Coronary Artery Disease indication
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Prevention of Transient Ischemic Attacks off-label use
Alcoholism contraindication 7200002
Hypothyroidism contraindication 40930008 DOID:1459
Low blood pressure contraindication 45007003
Hepatic failure contraindication 59927004
Chronic idiopathic constipation contraindication 82934008
Kidney disease contraindication 90708001 DOID:557
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Severe Aortic Valve Stenosis contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic
pKa2 11.82 acidic
pKa3 13.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 8 WOMBAT-PK CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
Cytochrome P450 3A4 Enzyme IC50 5.29 CHEMBL
Histone deacetylase 6 Enzyme IC50 4.84 CHEMBL
Histone deacetylase 1 Enzyme IC50 4.93 CHEMBL
Histone deacetylase 2 Enzyme IC50 4.65 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.42 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 4.49 CHEMBL

External reference:

IDSource
A0JWA85V8F UNII
4024041 VUID
N0000022046 NUI
D00887 KEGG_DRUG
134523-03-8 SECONDARY_CAS_RN
4020999 VANDF
4024041 VANDF
C0286651 UMLSCUI
CHEBI:39548 CHEBI
117 PDB_CHEM_ID
CHEMBL1487 ChEMBL_ID
CHEMBL1790017 ChEMBL_ID
CHEMBL393220 ChEMBL_ID
DB01076 DRUGBANK_ID
D000069059 MESH_DESCRIPTOR_UI
60823 PUBCHEM_CID
7259 INN_ID
2949 IUPHAR_LIGAND_ID
1297766 RXNORM
186242 MMSL
34584 MMSL
4226 MMSL
d04105 MMSL
006321 NDDF
006322 NDDF
108600003 SNOMEDCT_US
108601004 SNOMEDCT_US
373444002 SNOMEDCT_US
725658002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2960 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2970 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2980 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0155 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0156 TABLET, FILM COATED 20 mg ORAL NDA 29 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0157 TABLET, FILM COATED 40 mg ORAL NDA 29 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0158 TABLET, FILM COATED 80 mg ORAL NDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5056 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5057 TABLET, FILM COATED 80 mg ORAL ANDA 28 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5058 TABLET, FILM COATED 40 mg ORAL ANDA 28 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5059 TABLET, FILM COATED 20 mg ORAL ANDA 28 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3950 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3951 TABLET, FILM COATED 20 mg ORAL ANDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3952 TABLET, FILM COATED 40 mg ORAL ANDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3953 TABLET, FILM COATED 80 mg ORAL ANDA 29 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4510 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4511 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4512 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4513 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4514 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4515 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4516 TABLET, FILM COATED 80 mg ORAL ANDA 31 sections