atorvastatin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 257 134523-00-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CI-981
  • CI981
  • atorvastatin calcium hydrate
  • atorvastatin calcium anhydrous
  • atorvastatin
  • atorvastatin acid
  • cardyl
  • atorvastatin calcium
  • atorvastatin calcium trihydrate
A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.
  • Molecular weight: 558.65
  • Formula: C33H35FN2O5
  • CLOGP: 4.46
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 4
  • TPSA: 111.79
  • ALOGS: -5.95
  • ROTB: 12

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.02 mg/mL Hosey CM, Chan R, Benet LZ
EoM (Fraction excreted unchanged in urine) 1 % Hosey CM, Chan R, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.05 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Dec. 17, 1996 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 2271.95 29.48 663 5547 22670 2329205
Rhabdomyolysis 1733.99 29.48 415 5795 6289 2345586
Drug hypersensitivity 1197.75 29.48 491 5719 46152 2305723
Drug interaction 873.11 29.48 344 5866 28819 2323056
Myopathy 798.72 29.48 169 6041 1374 2350501
Immune-mediated myositis 736.14 29.48 114 6096 69 2351806
Blood creatine phosphokinase increased 730.68 29.48 198 6012 4938 2346937
Muscular weakness 687.78 29.48 242 5968 14655 2337220
Acute kidney injury 623.33 29.48 268 5942 27854 2324021
Muscle spasms 521.96 29.48 219 5991 21347 2330528
Drug-induced liver injury 376.90 29.48 110 6100 3589 2348286
Liver function test abnormal 368.99 29.48 128 6082 7362 2344513
Asthenia 368.38 29.48 222 5988 46704 2305171
Drug intolerance 330.15 29.48 139 6071 13578 2338297
Autoimmune hepatitis 330.14 29.48 84 6126 1611 2350264
Hepatitis 326.41 29.48 112 6098 6225 2345650
Myositis 319.28 29.48 78 6132 1257 2350618
Alanine aminotransferase increased 317.16 29.48 136 6074 13896 2337979
Pruritus 293.97 29.48 187 6023 43153 2308722
Arthralgia 278.77 29.48 197 6013 54088 2297787
Nausea 272.29 29.48 263 5947 111926 2239949
Completed suicide 270.41 29.48 138 6072 20896 2330979
Pain in extremity 257.55 29.48 171 6039 42369 2309506
Dyspnoea 246.13 29.48 213 5997 78520 2273355
Fatigue 242.18 29.48 218 5992 84655 2267220
Cholestasis 228.03 29.48 75 6135 3646 2348229
Malaise 227.31 29.48 176 6034 55409 2296466
Aspartate aminotransferase increased 223.02 29.48 103 6107 12509 2339366
Dizziness 221.05 29.48 177 6033 58488 2293387
Polymyositis 194.27 29.48 41 6169 325 2351550
Interstitial lung disease 190.47 29.48 80 6130 7732 2344143
Paraesthesia 189.54 29.48 111 6099 21977 2329898
Jaundice 188.41 29.48 72 6138 5436 2346439
Decreased appetite 183.91 29.48 120 6090 28771 2323104
Depression 172.10 29.48 114 6096 28018 2323857
Necrotising myositis 169.44 29.48 28 6182 39 2351836
Vomiting 169.35 29.48 166 6044 71436 2280439
Gamma-glutamyltransferase increased 162.99 29.48 65 6145 5497 2346378
Gait disturbance 161.66 29.48 101 6109 22444 2329431
Fall 155.93 29.48 132 6078 46967 2304908
Pain 154.79 29.48 148 6062 61709 2290166
Insomnia 154.06 29.48 103 6107 25684 2326191
Hepatitis acute 153.32 29.48 45 6165 1490 2350385
Toxicity to various agents 149.61 29.48 111 6099 32643 2319232
Liver function test increased 148.63 29.48 52 6158 3049 2348826
Sleep disorder 143.39 29.48 62 6148 6427 2345448
Amnesia 143.13 29.48 64 6146 7189 2344686
Diarrhoea 142.81 29.48 163 6047 83401 2268474
Back pain 135.03 29.48 103 6107 31556 2320319
Headache 129.55 29.48 152 6058 80027 2271848
Hepatocellular injury 124.40 29.48 49 6161 4006 2347869
Product substitution issue 123.78 29.48 52 6158 5017 2346858
Blood alkaline phosphatase increased 123.55 29.48 56 6154 6489 2345386
Hyperkalaemia 122.68 29.48 54 6156 5839 2346036
Renal failure 122.46 29.48 77 6133 17272 2334603
Hepatic function abnormal 120.96 29.48 54 6156 6038 2345837
Hypertension 118.79 29.48 90 6120 27271 2324604
Acute myocardial infarction 117.26 29.48 50 6160 5005 2346870
Blood cholesterol increased 115.52 29.48 50 6160 5191 2346684
Hepatic enzyme increased 113.31 29.48 60 6150 9742 2342133
Abdominal pain upper 112.40 29.48 80 6130 22020 2329855
Confusional state 112.17 29.48 83 6127 24261 2327614
Liver disorder 112.03 29.48 52 6158 6362 2345513
Hepatitis cholestatic 111.51 29.48 33 6177 1124 2350751
Muscle disorder 107.68 29.48 30 6180 820 2351055
Abnormal loss of weight 104.57 29.48 28 6182 657 2351218
Condition aggravated 102.31 29.48 88 6122 31891 2319984
Transaminases increased 101.87 29.48 44 6166 4543 2347332
Chest pain 101.51 29.48 83 6127 28054 2323821
Hypotension 101.23 29.48 88 6122 32348 2319527
Multiple organ dysfunction syndrome 100.44 29.48 51 6159 7590 2344285
Abdominal pain 98.79 29.48 89 6121 34285 2317590
Cough 97.65 29.48 87 6123 33030 2318845
Muscle necrosis 97.29 29.48 20 6190 137 2351738
Liver injury 96.46 29.48 35 6175 2279 2349596
Oedema peripheral 96.17 29.48 75 6135 23688 2328187
Drug ineffective 95.48 29.48 148 6062 101476 2250399
Depressed mood 93.44 29.48 43 6167 5155 2346720
Pancreatitis acute 92.30 29.48 39 6171 3814 2348061
Weight decreased 90.58 29.48 78 6132 28293 2323582
Chromaturia 90.54 29.48 35 6175 2718 2349157
Rash 89.55 29.48 109 6101 59449 2292426
Atrial fibrillation 89.39 29.48 58 6152 13710 2338165
Hyponatraemia 86.18 29.48 56 6154 13269 2338606
Alopecia 83.76 29.48 67 6143 21934 2329941
Flatulence 83.11 29.48 38 6172 4487 2347388
Blood glucose increased 82.80 29.48 53 6157 12237 2339638
Hepatitis toxic 76.77 29.48 22 6188 667 2351208
Tinnitus 75.52 29.48 37 6173 5098 2346777
Polymyalgia rheumatica 74.98 29.48 20 6190 462 2351413
Hepatic necrosis 74.53 29.48 24 6186 1086 2350789
Hepatomegaly 74.05 29.48 27 6183 1782 2350093
Dysphagia 73.58 29.48 50 6160 12755 2339120
Visual impairment 72.58 29.48 48 6162 11707 2340168
Dermatomyositis 72.11 29.48 19 6191 418 2351457
Renal impairment 71.66 29.48 45 6165 10047 2341828
Gait inability 70.33 29.48 37 6173 5918 2345957
Colitis microscopic 70.12 29.48 22 6188 914 2350961
Blood pressure increased 69.51 29.48 54 6156 16932 2334943
Pemphigoid 69.08 29.48 22 6188 960 2350915
Labile blood pressure 68.68 29.48 16 6194 207 2351668
Memory impairment 68.46 29.48 48 6162 12875 2339000
Anaphylactic reaction 68.22 29.48 43 6167 9662 2342213
Metabolic acidosis 67.26 29.48 36 6174 5962 2345913
Muscle atrophy 67.03 29.48 22 6188 1058 2350817
Cardiac failure 66.58 29.48 46 6164 12048 2339827
Hepatic failure 66.20 29.48 35 6175 5654 2346221
Balance disorder 65.56 29.48 42 6168 9705 2342170
Jaundice cholestatic 65.44 29.48 19 6191 604 2351271
Swollen tongue 65.39 29.48 34 6176 5309 2346566
Lower respiratory tract infection 64.90 29.48 34 6176 5390 2346485
Nightmare 64.61 29.48 30 6180 3667 2348208
Hypokalaemia 64.55 29.48 43 6167 10611 2341264
Acute hepatic failure 64.12 29.48 27 6183 2615 2349260
Vision blurred 63.01 29.48 48 6162 14620 2337255
Drug reaction with eosinophilia and systemic symptoms 61.53 29.48 33 6177 5485 2346390
High density lipoprotein decreased 60.94 29.48 16 6194 347 2351528
Disturbance in attention 60.61 29.48 33 6177 5652 2346223
Cholestatic liver injury 60.41 29.48 15 6195 258 2351617
Urticaria 60.31 29.48 58 6152 24203 2327672
Bradycardia 59.78 29.48 40 6170 9941 2341934
Hallucination 59.52 29.48 37 6173 8111 2343764
Labelled drug-drug interaction medication error 59.08 29.48 21 6189 1287 2350588
Pyrexia 58.50 29.48 84 6126 53624 2298251
Acidosis 58.43 29.48 22 6188 1588 2350287
Stoma site haemorrhage 56.41 29.48 12 6198 99 2351776
Vascular stent stenosis 56.09 29.48 12 6198 102 2351773
Myocardial infarction 56.05 29.48 50 6160 18963 2332912
Palpitations 56.05 29.48 47 6163 16409 2335466
Hypoglycaemia 55.97 29.48 36 6174 8371 2343504
Cardiac arrest 55.78 29.48 45 6165 14885 2336990
Syncope 55.02 29.48 47 6163 16828 2335047
Swelling 54.25 29.48 46 6164 16304 2335571
Blood bilirubin increased 54.15 29.48 30 6180 5315 2346560
Thrombocytopenia 53.81 29.48 49 6161 19082 2332793
Blood creatinine increased 53.17 29.48 38 6172 10495 2341380
Joint swelling 53.12 29.48 46 6164 16773 2335102
Mixed liver injury 52.87 29.48 14 6196 314 2351561
Anxiety 52.80 29.48 59 6151 29300 2322575
Myasthenia gravis 52.41 29.48 16 6194 606 2351269
Hypersensitivity 52.31 29.48 53 6157 23540 2328335
Overdose 52.15 29.48 49 6161 19858 2332017
Type 2 diabetes mellitus 51.84 29.48 22 6188 2172 2349703
Loss of personal independence in daily activities 51.59 29.48 29 6181 5282 2346593
Hepatitis fulminant 51.55 29.48 16 6194 641 2351234
Suicide attempt 50.83 29.48 38 6172 11244 2340631
Constipation 50.55 29.48 50 6160 21579 2330296
Macroglossia 49.90 29.48 11 6199 109 2351766
Myoglobin blood increased 49.37 29.48 13 6197 285 2351590
Somnolence 48.89 29.48 51 6159 23434 2328441
Eosinophilia 48.50 29.48 23 6187 2947 2348928
Hypertransaminasaemia 47.95 29.48 15 6195 617 2351258
Pulmonary fibrosis 47.93 29.48 22 6188 2618 2349257
Myoglobinuria 47.73 29.48 10 6200 76 2351799
Gastrointestinal haemorrhage 47.55 29.48 38 6172 12397 2339478
Amylase increased 46.46 29.48 17 6193 1132 2350743
Angioedema 46.35 29.48 32 6178 8364 2343511
Gynaecomastia 46.19 29.48 9 6201 45 2351830
Carotid arteriosclerosis 46.15 29.48 11 6199 158 2351717
Lactic acidosis 46.15 29.48 27 6183 5303 2346572
Apolipoprotein A-I decreased 45.96 29.48 7 6203 3 2351872
Dysstasia 45.68 29.48 22 6188 2917 2348958
Musculoskeletal pain 45.52 29.48 35 6175 10795 2341080
Low density lipoprotein increased 44.86 29.48 17 6193 1249 2350626
Traumatic coma 44.68 29.48 7 6203 5 2351870
Abdominal distension 44.54 29.48 34 6176 10377 2341498
Product use in unapproved indication 44.48 29.48 35 6175 11165 2340710
Feeling cold 44.23 29.48 22 6188 3128 2348747
Cerebrovascular accident 44.11 29.48 45 6165 20141 2331734
Coronary artery stenosis 44.09 29.48 15 6195 806 2351069
Hypoaesthesia 44.05 29.48 45 6165 20170 2331705
Arterial stenosis 43.69 29.48 10 6200 119 2351756
Feeling abnormal 43.43 29.48 48 6162 23533 2328342
Gastrointestinal disorder 42.33 29.48 31 6179 8886 2342989
Anuria 42.13 29.48 18 6192 1806 2350069
Dysarthria 41.97 29.48 27 6183 6275 2345600
Musculoskeletal stiffness 41.73 29.48 35 6175 12212 2339663
Ocular myasthenia 41.57 29.48 8 6202 37 2351838
Electrocardiogram QT prolonged 41.30 29.48 29 6181 7785 2344090
Eczema 40.95 29.48 21 6189 3184 2348691
Hepatic steatosis 40.90 29.48 21 6189 3192 2348683
Lethargy 40.65 29.48 30 6180 8700 2343175
Pulmonary oedema 40.49 29.48 28 6182 7335 2344540
Movement disorder 40.44 29.48 20 6190 2808 2349067
Chest discomfort 40.28 29.48 37 6173 14558 2337317
Autoimmune disorder 40.27 29.48 14 6196 803 2351072
Oliguria 40.20 29.48 16 6194 1341 2350534
Intentional overdose 39.91 29.48 33 6177 11288 2340587
Peripheral swelling 39.85 29.48 40 6170 17557 2334318
Hypersensitivity pneumonitis 39.76 29.48 12 6198 437 2351438
Tremor 39.68 29.48 43 6167 20618 2331257
Polyneuropathy 39.41 29.48 17 6193 1746 2350129
Diplopia 39.40 29.48 21 6189 3444 2348431
Blood lactate dehydrogenase increased 39.29 29.48 21 6189 3463 2348412
Dehydration 38.69 29.48 44 6166 22251 2329624
Myocardial ischaemia 38.41 29.48 18 6192 2244 2349631
Urinary retention 38.28 29.48 21 6189 3646 2348229
International normalised ratio increased 38.25 29.48 27 6183 7309 2344566
Prescription drug used without a prescription 38.16 29.48 10 6200 215 2351660
Pancreatitis 38.15 29.48 28 6182 8051 2343824
Laryngospasm 38.15 29.48 13 6197 702 2351173
Haematuria 37.71 29.48 22 6188 4296 2347579
Nodular rash 37.71 29.48 8 6202 65 2351810
Epistaxis 37.63 29.48 30 6180 9749 2342126
Cell death 37.48 29.48 11 6199 363 2351512
Helicobacter gastritis 37.12 29.48 10 6200 240 2351635
Incorrect dosage administered 37.06 29.48 11 6199 378 2351497
Dermatitis allergic 36.94 29.48 17 6193 2034 2349841
Respiratory failure 36.76 29.48 34 6176 13494 2338381
Hepatotoxicity 36.52 29.48 20 6190 3461 2348414
Subacute cutaneous lupus erythematosus 36.46 29.48 11 6199 400 2351475
Malignant polyp 36.45 29.48 6 6204 8 2351867
Night sweats 36.42 29.48 20 6190 3480 2348395
Lip swelling 35.47 29.48 22 6188 4799 2347076
Hepatic cyst 35.16 29.48 12 6198 651 2351224
Diverticular perforation 35.05 29.48 11 6199 457 2351418
Left ventricular dysfunction 34.58 29.48 14 6196 1226 2350649
Spur cell anaemia 34.31 29.48 6 6204 14 2351861
Anembryonic gestation 34.24 29.48 9 6201 196 2351679
Speech disorder 34.18 29.48 24 6186 6440 2345435
Coronary artery thrombosis 34.08 29.48 10 6200 330 2351545
Diabetic retinopathy 33.85 29.48 10 6200 338 2351537
Weight increased 33.63 29.48 41 6169 22296 2329579
Musculoskeletal discomfort 33.21 29.48 16 6194 2122 2349753
Cardio-respiratory arrest 32.95 29.48 27 6183 9119 2342756
Lymphomatoid papulosis 32.87 29.48 7 6203 58 2351817
Dysgeusia 32.65 29.48 26 6184 8433 2343442
Pollakiuria 32.44 29.48 19 6191 3737 2348138
Glycosylated haemoglobin increased 32.40 29.48 15 6195 1819 2350056
Burning sensation 32.24 29.48 25 6185 7803 2344072
Immobile 32.21 29.48 11 6199 598 2351277
Disorientation 32.17 29.48 23 6187 6349 2345526
Intentional product misuse 32.08 29.48 27 6183 9462 2342413
Waist circumference increased 31.87 29.48 8 6202 144 2351731
Urine output decreased 31.84 29.48 14 6196 1505 2350370
Asthma 31.83 29.48 29 6181 11285 2340590
Cholelithiasis 31.74 29.48 22 6188 5781 2346094
Anaemia 31.53 29.48 50 6160 34742 2317133
Electrocardiogram T wave inversion 31.52 29.48 11 6199 638 2351237
Restlessness 31.50 29.48 20 6190 4543 2347332
Crepitations 31.24 29.48 11 6199 655 2351220
Autoimmune myositis 31.14 29.48 5 6205 5 2351870
Haematemesis 30.97 29.48 19 6191 4063 2347812
Raynaud's phenomenon 30.73 29.48 12 6198 956 2350919
Laryngeal oedema 30.70 29.48 13 6197 1275 2350600
Vertigo 30.28 29.48 26 6184 9358 2342517
Obstructive airways disorder 29.90 29.48 13 6197 1360 2350515
Erythema 29.78 29.48 41 6169 25118 2326757
Cerebral infarction 29.52 29.48 19 6191 4418 2347457

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rhabdomyolysis 2588.06 28.97 730 6941 10360 1728750
Myalgia 2587.70 28.97 788 6883 14870 1724240
Blood creatine phosphokinase increased 1327.48 28.97 416 7255 8440 1730670
Drug interaction 1104.80 28.97 493 7178 27465 1711645
Immune-mediated myositis 1018.42 28.97 175 7496 86 1739024
Myopathy 931.65 28.97 225 7446 1588 1737522
Acute kidney injury 738.25 28.97 403 7268 34541 1704569
Muscular weakness 634.78 28.97 250 7421 9999 1729111
Drug hypersensitivity 550.25 28.97 253 7418 14882 1724228
Muscle spasms 491.27 28.97 216 7455 11405 1727705
Completed suicide 459.63 28.97 229 7442 16083 1723027
Arthralgia 353.32 28.97 218 7453 23226 1715884
Myositis 322.95 28.97 95 7576 1508 1737602
Asthenia 293.59 28.97 226 7445 34444 1704666
Fatigue 289.17 28.97 263 7408 50518 1688592
Dyspnoea 285.51 28.97 264 7407 51795 1687315
Pain in extremity 255.82 28.97 163 7508 18309 1720801
Pruritus 249.62 28.97 175 7496 23047 1716063
Liver function test abnormal 246.44 28.97 108 7563 5618 1733492
Alanine aminotransferase increased 223.02 28.97 129 7542 12149 1726961
Hepatic enzyme increased 203.87 28.97 99 7572 6522 1732588
Muscle rupture 202.41 28.97 51 7620 432 1738678
Jaundice 199.85 28.97 95 7576 5967 1733143
Hypotension 186.80 28.97 163 7508 29491 1709619
Renal failure 183.28 28.97 137 7534 19880 1719230
Hepatitis 182.96 28.97 84 7587 4871 1734239
Cholestasis 180.21 28.97 76 7595 3589 1735521
Malaise 177.18 28.97 158 7513 29407 1709703
Aspartate aminotransferase increased 176.82 28.97 106 7565 10650 1728460
Interstitial lung disease 176.30 28.97 102 7569 9594 1729516
Pancreatitis acute 169.01 28.97 75 7596 4012 1735098
Blood cholesterol increased 163.08 28.97 67 7604 2959 1736151
Transaminases increased 162.36 28.97 72 7599 3845 1735265
Dizziness 160.62 28.97 160 7511 34201 1704909
Tendon rupture 151.88 28.97 55 7616 1717 1737393
Toxicity to various agents 151.70 28.97 144 7527 28997 1710113
Chromaturia 150.74 28.97 61 7610 2589 1736521
Bradycardia 150.64 28.97 95 7576 10439 1728671
Condition aggravated 148.83 28.97 124 7547 21026 1718084
Back pain 145.97 28.97 111 7560 16502 1722608
Muscle atrophy 140.66 28.97 47 7624 1148 1737962
Necrotising myositis 138.45 28.97 26 7645 37 1739073
Polymyositis 137.07 28.97 34 7637 268 1738842
Headache 131.73 28.97 144 7527 34232 1704878
Nausea 131.61 28.97 175 7496 51021 1688089
Chest pain 128.27 28.97 111 7560 19803 1719307
Muscle necrosis 128.04 28.97 30 7641 180 1738930
Cardiac failure 125.89 28.97 91 7580 12511 1726599
Gait disturbance 125.45 28.97 91 7580 12579 1726531
Hepatitis cholestatic 124.51 28.97 44 7627 1277 1737833
Hypertension 124.43 28.97 108 7563 19340 1719770
Paraesthesia 124.31 28.97 84 7587 10367 1728743
Personality change 123.50 28.97 42 7629 1084 1738026
Renal impairment 123.19 28.97 89 7582 12225 1726885
Fall 122.01 28.97 124 7547 27090 1712020
Intentional overdose 121.85 28.97 74 7597 7596 1731514
Pain 120.48 28.97 122 7549 26535 1712575
Drug-induced liver injury 119.82 28.97 55 7616 3182 1735928
Product substitution issue 119.03 28.97 55 7616 3231 1735879
Blood pressure increased 117.43 28.97 82 7589 10671 1728439
Drug ineffective 117.20 28.97 186 7485 63615 1675495
Hepatocellular injury 116.79 28.97 54 7617 3177 1735933
Weight decreased 115.55 28.97 111 7560 22642 1716468
Amnesia 115.01 28.97 61 7610 4830 1734280
Overdose 111.38 28.97 95 7576 16606 1722504
Gynaecomastia 107.39 28.97 45 7626 2087 1737023
Oedema peripheral 106.86 28.97 90 7581 15460 1723650
Low density lipoprotein increased 105.70 28.97 36 7635 933 1738177
Irritability 105.27 28.97 60 7611 5472 1733638
Blood triglycerides increased 105.16 28.97 47 7624 2553 1736557
Rash 105.06 28.97 136 7535 38557 1700553
Confusional state 104.62 28.97 102 7569 21176 1717934
Cough 103.82 28.97 97 7574 19100 1720010
Diarrhoea 102.94 28.97 160 7511 53692 1685418
Gamma-glutamyltransferase increased 101.61 28.97 57 7614 5041 1734069
Depression 101.42 28.97 90 7581 16579 1722531
Diabetes mellitus 100.43 28.97 63 7608 6845 1732265
Eczema 100.39 28.97 44 7627 2280 1736830
Hepatic failure 99.03 28.97 59 7612 5844 1733266
Memory impairment 97.45 28.97 61 7610 6602 1732508
Multiple organ dysfunction syndrome 97.45 28.97 69 7602 9173 1729937
Cardiogenic shock 94.91 28.97 43 7628 2411 1736699
Dysphagia 93.77 28.97 70 7601 10098 1729012
Sleep disorder 93.61 28.97 50 7621 4013 1735097
Hyperkalaemia 90.54 28.97 64 7607 8483 1730627
Amyotrophic lateral sclerosis 89.66 28.97 24 7647 263 1738847
Abdominal pain 89.15 28.97 94 7577 21396 1717714
Tendonitis 88.45 28.97 35 7636 1398 1737712
Labelled drug-drug interaction medication error 86.90 28.97 34 7637 1317 1737793
Quadriparesis 86.85 28.97 23 7648 241 1738869
Cognitive disorder 85.16 28.97 48 7623 4282 1734828
Neck pain 84.86 28.97 44 7627 3322 1735788
Musculoskeletal pain 83.24 28.97 50 7621 5024 1734086
High density lipoprotein decreased 81.89 28.97 27 7644 631 1738479
Vomiting 80.39 28.97 119 7552 38196 1700914
Blood creatinine increased 80.26 28.97 73 7598 13873 1725237
Blood creatine phosphokinase MB increased 78.72 28.97 24 7647 431 1738679
Polyneuropathy 78.31 28.97 34 7637 1721 1737389
Swollen tongue 77.44 28.97 39 7632 2769 1736341
Acute myocardial infarction 76.67 28.97 58 7613 8529 1730581
Insomnia 76.18 28.97 76 7595 16200 1722910
Erectile dysfunction 75.55 28.97 45 7626 4452 1734658
Arrhythmia 75.42 28.97 50 7621 5966 1733144
Rash papular 75.22 28.97 33 7638 1713 1737397
Hepatitis acute 75.13 28.97 30 7641 1227 1737883
Angioedema 72.72 28.97 59 7612 9605 1729505
Pulmonary fibrosis 72.66 28.97 36 7635 2468 1736642
Thrombocytopenia 72.63 28.97 84 7587 21165 1717945
Dermatomyositis 72.45 28.97 20 7651 248 1738862
Atrial fibrillation 71.52 28.97 71 7600 15040 1724070
Acute hepatic failure 70.25 28.97 33 7638 2010 1737100
International normalised ratio increased 69.58 28.97 54 7617 8245 1730865
Epistaxis 69.54 28.97 54 7617 8252 1730858
Oedema 68.91 28.97 50 7621 6898 1732212
Syncope 67.84 28.97 67 7604 14102 1725008
Compartment syndrome 66.21 28.97 22 7649 527 1738583
Abdominal pain upper 66.06 28.97 59 7612 10942 1728168
Angina pectoris 66.05 28.97 43 7628 4975 1734135
Atrial flutter 65.64 28.97 31 7640 1911 1737199
Hypoaesthesia 65.60 28.97 56 7615 9779 1729331
Gout 65.37 28.97 34 7637 2582 1736528
Lactic acidosis 65.19 28.97 43 7628 5086 1734024
Peripheral swelling 64.95 28.97 51 7620 7920 1731190
Blood alkaline phosphatase increased 64.69 28.97 43 7628 5152 1733958
Drug intolerance 63.26 28.97 45 7626 6017 1733093
Skin exfoliation 62.49 28.97 40 7631 4495 1734615
Electrocardiogram QRS complex prolonged 62.46 28.97 23 7648 752 1738358
Glycogen storage disease type V 62.28 28.97 11 7660 8 1739102
Autoimmune disorder 61.21 28.97 19 7652 363 1738747
Liver injury 60.43 28.97 29 7642 1853 1737257
Depression suicidal 60.36 28.97 17 7654 228 1738882
Myasthenia gravis 60.04 28.97 21 7650 590 1738520
Hepatic function abnormal 59.23 28.97 46 7625 7028 1732082
Somnolence 58.56 28.97 67 7604 16672 1722438
Swelling face 57.98 28.97 38 7633 4445 1734665
Arteriosclerosis 57.91 28.97 28 7643 1819 1737291
Blood bilirubin increased 57.76 28.97 43 7628 6167 1732943
Pyrexia 57.38 28.97 114 7557 46286 1692824
Mood altered 57.12 28.97 29 7642 2093 1737017
Muscle injury 56.62 28.97 17 7654 289 1738821
Palpitations 56.37 28.97 44 7627 6770 1732340
Tubulointerstitial nephritis 56.02 28.97 32 7639 2926 1736184
Nightmare 55.07 28.97 31 7640 2756 1736354
Haematoma 54.86 28.97 35 7636 3910 1735200
Hepatotoxicity 54.77 28.97 32 7639 3052 1736058
Balance disorder 53.51 28.97 40 7631 5772 1733338
Muscle disorder 53.36 28.97 19 7652 563 1738547
Weight increased 53.04 28.97 53 7618 11304 1727806
Paresis 52.22 28.97 17 7654 381 1738729
Blood pressure decreased 51.92 28.97 44 7627 7602 1731508
Hepatic steatosis 51.75 28.97 29 7642 2555 1736555
Coronary artery disease 51.70 28.97 49 7622 9797 1729313
Aggression 51.65 28.97 45 7626 8070 1731040
Swelling 51.11 28.97 42 7629 6954 1732156
Hyperglycaemia 50.82 28.97 37 7634 5128 1733982
Anxiety 50.71 28.97 60 7611 15467 1723643
Dysarthria 50.22 28.97 37 7634 5222 1733888
Liver disorder 50.13 28.97 38 7633 5598 1733512
Erythema 49.97 28.97 57 7614 14131 1724979
Hypercholesterolaemia 49.28 28.97 22 7649 1190 1737920
Tricuspid valve incompetence 48.69 28.97 22 7649 1224 1737886
Hypovolaemic shock 48.52 28.97 20 7651 888 1738222
Body temperature decreased 48.44 28.97 21 7650 1058 1738052
Joint swelling 48.22 28.97 39 7632 6314 1732796
Urinary incontinence 47.56 28.97 28 7643 2708 1736402
Dyspepsia 47.44 28.97 35 7636 4950 1734160
Chronic kidney disease 47.24 28.97 33 7638 4284 1734826
Stevens-Johnson syndrome 47.21 28.97 30 7641 3327 1735783
Gait inability 47.16 28.97 30 7641 3333 1735777
Hyperhidrosis 47.10 28.97 52 7619 12436 1726674
Blood urea increased 46.92 28.97 34 7637 4677 1734433
Disorientation 46.72 28.97 36 7635 5433 1733677
Musculoskeletal discomfort 46.49 28.97 20 7651 989 1738121
Neuromyopathy 46.38 28.97 13 7658 171 1738939
Myocardial infarction 45.24 28.97 76 7595 27098 1712012
Low density lipoprotein decreased 44.74 28.97 14 7657 275 1738835
Thrombocytopenic purpura 44.69 28.97 14 7657 276 1738834
Monoparesis 44.55 28.97 14 7657 279 1738831
Blister 44.13 28.97 31 7640 4061 1735049
Superinfection 44.09 28.97 14 7657 289 1738821
Lethargy 44.04 28.97 39 7632 7145 1731965
Facial asymmetry 43.87 28.97 10 7661 52 1739058
Lipids abnormal 43.86 28.97 11 7660 91 1739019
Cholelithiasis 43.80 28.97 28 7643 3137 1735973
Speech disorder 43.43 28.97 32 7639 4516 1734594
Ischaemic stroke 43.34 28.97 28 7643 3194 1735916
Neuropathy peripheral 42.86 28.97 43 7628 9210 1729900
Decreased appetite 42.74 28.97 69 7602 23802 1715308
Rash erythematous 42.67 28.97 30 7641 3935 1735175
Haematuria 42.32 28.97 39 7632 7521 1731589
C-reactive protein increased 42.29 28.97 35 7636 5850 1733260
Loss of libido 42.20 28.97 17 7654 711 1738399
Mitral valve incompetence 42.20 28.97 23 7648 1919 1737191
Myopathy toxic 42.18 28.97 11 7660 108 1739002
Deafness 41.93 28.97 23 7648 1943 1737167
Impatience 41.90 28.97 11 7660 111 1738999
Blood glucose increased 41.52 28.97 45 7626 10539 1728571
Dyspnoea exertional 41.36 28.97 30 7641 4131 1734979
Skin irritation 41.07 28.97 17 7654 763 1738347
Eosinophilia 41.04 28.97 28 7643 3499 1735611
Pseudomonal sepsis 40.79 28.97 14 7657 371 1738739
Cardiac failure chronic 40.58 28.97 16 7655 632 1738478
Musculoskeletal stiffness 40.26 28.97 34 7637 5842 1733268
Genital swelling 40.12 28.97 9 7662 43 1739067
Glycosylated haemoglobin increased 39.99 28.97 22 7649 1869 1737241
Muscle haemorrhage 39.93 28.97 17 7654 819 1738291
Chest discomfort 39.46 28.97 37 7634 7294 1731816
Hypoacusis 39.23 28.97 24 7647 2489 1736621
Ejection fraction decreased 39.09 28.97 23 7648 2222 1736888
Actinic keratosis 38.64 28.97 15 7656 568 1738542
Leukopenia 38.52 28.97 39 7632 8441 1730669
Myoglobin blood increased 38.18 28.97 14 7657 452 1738658
Paralysis 37.92 28.97 19 7652 1333 1737777
Diabetes mellitus inadequate control 37.78 28.97 21 7650 1821 1737289
Abnormal weight gain 37.67 28.97 11 7660 169 1738941
Rash maculo-papular 37.50 28.97 27 7644 3676 1735434
Mixed liver injury 37.20 28.97 12 7659 261 1738849
Orthostatic hypotension 37.01 28.97 26 7645 3405 1735705
Contusion 36.95 28.97 31 7640 5278 1733832
General physical health deterioration 36.85 28.97 47 7624 13071 1726039
Diastolic dysfunction 36.76 28.97 14 7657 503 1738607
Poisoning deliberate 36.54 28.97 16 7655 826 1738284
Diplopia 36.22 28.97 23 7648 2547 1736563
Idiopathic pulmonary fibrosis 35.86 28.97 15 7656 691 1738419
Obesity 35.77 28.97 17 7654 1062 1738048
Discomfort 35.68 28.97 23 7648 2613 1736497
Autoimmune hepatitis 35.64 28.97 15 7656 702 1738408
Brain natriuretic peptide increased 35.41 28.97 14 7657 557 1738553
Renal tubular necrosis 35.04 28.97 21 7650 2098 1737012
Type IIa hyperlipidaemia 34.84 28.97 7 7664 17 1739093
Anaemia 34.69 28.97 71 7600 29386 1709724
Circulatory collapse 34.47 28.97 25 7646 3442 1735668
Metabolic acidosis 34.45 28.97 30 7641 5372 1733738
Blood pressure inadequately controlled 34.45 28.97 14 7657 599 1738511
Pancreatitis 34.39 28.97 34 7637 7153 1731957
Ewing's sarcoma 34.13 28.97 8 7663 48 1739062
Limb discomfort 34.02 28.97 18 7653 1414 1737696
Acquired haemophilia 33.41 28.97 10 7661 168 1738942
Treatment noncompliance 33.40 28.97 29 7642 5172 1733938
Pemphigus 33.32 28.97 11 7660 258 1738852
Joint stiffness 33.30 28.97 19 7652 1732 1737378
Blood lactate dehydrogenase increased 33.16 28.97 25 7646 3650 1735460
Spur cell anaemia 33.09 28.97 6 7665 6 1739104
Drug dispensed to wrong patient 33.06 28.97 7 7664 24 1739086
Dry skin 32.94 28.97 25 7646 3687 1735423
Loss of personal independence in daily activities 32.64 28.97 21 7650 2378 1736732
Troponin increased 32.58 28.97 17 7654 1298 1737812
Pallor 32.56 28.97 24 7647 3387 1735723
Red blood cell sedimentation rate increased 32.55 28.97 16 7655 1077 1738033
Thrombotic thrombocytopenic purpura 32.33 28.97 14 7657 703 1738407
Tremor 32.17 28.97 44 7627 13087 1726023
Atrial thrombosis 32.02 28.97 13 7658 555 1738555
Blood immunoglobulin E increased 32.00 28.97 11 7660 293 1738817
Violence-related symptom 31.69 28.97 10 7661 202 1738908
Mesothelioma 31.60 28.97 8 7663 69 1739041
Hyperaesthesia teeth 31.59 28.97 9 7662 126 1738984
Eosinophil count increased 31.57 28.97 17 7654 1384 1737726
Hyperlipidaemia 31.54 28.97 20 7651 2209 1736901
Hyponatraemia 31.40 28.97 36 7635 8964 1730146
Feeling abnormal 31.34 28.97 40 7631 11126 1727984
Abdominal discomfort 31.14 28.97 36 7635 9045 1730065
Cerebrovascular accident 31.08 28.97 51 7620 17815 1721295
Tongue oedema 31.04 28.97 13 7658 601 1738509
Hypertriglyceridaemia 31.02 28.97 16 7655 1193 1737917
Haemodialysis 30.98 28.97 21 7650 2595 1736515
Cardiac ablation 30.66 28.97 9 7662 141 1738969
Muscle tightness 30.54 28.97 15 7656 1008 1738102
Therapeutic product effect incomplete 30.28 28.97 28 7643 5420 1733690
Respiratory failure 30.23 28.97 45 7626 14460 1724650
Faeces discoloured 30.15 28.97 20 7651 2384 1736726
Liver function test increased 30.07 28.97 17 7654 1522 1737588
Hypoglycaemia 29.85 28.97 34 7637 8404 1730706
Respiratory distress 29.63 28.97 27 7644 5130 1733980
Blood cholesterol decreased 29.42 28.97 10 7661 257 1738853
Tinnitus 29.42 28.97 22 7649 3173 1735937
Agranulocytosis 29.36 28.97 23 7648 3553 1735557
Mastitis 29.19 28.97 7 7664 47 1739063

Pharmacologic Action:

SourceCodeDescription
ATC C10AA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors in combination with other lipid modifying agents
ATC C10BA08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors in combination with other lipid modifying agents
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX15 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Slow Progression of Coronary Artery Disease indication
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Prevention of Transient Ischemic Attacks off-label use
Alcoholism contraindication 7200002
Hypothyroidism contraindication 40930008 DOID:1459
Low blood pressure contraindication 45007003
Hepatic failure contraindication 59927004
Chronic idiopathic constipation contraindication 82934008
Kidney disease contraindication 90708001 DOID:557
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Severe Aortic Valve Stenosis contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic
pKa2 11.82 acidic
pKa3 13.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 10MG BASE LIPITOR PFIZER N020702 Dec. 17, 1996 RX TABLET ORAL June 23, 2020 CLINICAL INFORMATION ADDED TO THE PACKAGE INSERT REGARDING USE OF ATORVASTATIN IN CHILDREN AND ADOLESCENTS AGES 10-17 WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HEFH)
EQ 20MG BASE LIPITOR PFIZER N020702 Dec. 17, 1996 RX TABLET ORAL June 23, 2020 CLINICAL INFORMATION ADDED TO THE PACKAGE INSERT REGARDING USE OF ATORVASTATIN IN CHILDREN AND ADOLESCENTS AGES 10-17 WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HEFH)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 8 WOMBAT-PK CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
Cytochrome P450 3A4 Enzyme IC50 5.29 CHEMBL
Histone deacetylase 6 Enzyme IC50 4.84 CHEMBL
Histone deacetylase 1 Enzyme IC50 4.93 CHEMBL
Histone deacetylase 2 Enzyme IC50 4.65 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.42 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 4.49 CHEMBL

External reference:

IDSource
D000069059 MESH_DESCRIPTOR_UI
4024041 VUID
N0000022046 NUI
C0286651 UMLSCUI
D00887 KEGG_DRUG
48A5M73Z4Q UNII
344423-98-9 SECONDARY_CAS_RN
108600003 SNOMEDCT_US
4024041 VANDF
006321 NDDF
d04105 MMSL
4226 MMSL
83367 RXNORM
373444002 SNOMEDCT_US
7259 INN_ID
CHEMBL393220 ChEMBL_ID
CHEMBL1487 ChEMBL_ID
DB01076 DRUGBANK_ID
117 PDB_CHEM_ID
CHEBI:39548 CHEBI
2949 IUPHAR_LIGAND_ID
CHEMBL1790017 ChEMBL_ID
60823 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2960 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2970 TABLET, FILM COATED 20 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2980 TABLET, FILM COATED 40 mg ORAL NDA 19 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0155 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0156 TABLET, FILM COATED 20 mg ORAL NDA 19 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0157 TABLET, FILM COATED 40 mg ORAL NDA 19 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0158 TABLET, FILM COATED 80 mg ORAL NDA 19 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5056 TABLET, FILM COATED 10 mg ORAL ANDA 18 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5057 TABLET, FILM COATED 80 mg ORAL ANDA 18 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5058 TABLET, FILM COATED 40 mg ORAL ANDA 18 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5059 TABLET, FILM COATED 20 mg ORAL ANDA 18 sections
ATORVASTATIN CALCIUM HUMAN PRESCRIPTION DRUG LABEL 1 0179-0141 TABLET, FILM COATED 80 mg ORAL NDA authorized generic 19 sections
ATORVASTATIN CALCIUM HUMAN PRESCRIPTION DRUG LABEL 1 0179-0214 TABLET, FILM COATED 40 mg ORAL NDA authorized generic 19 sections
ATORVASTATIN CALCIUM HUMAN PRESCRIPTION DRUG LABEL 1 0179-0215 TABLET, FILM COATED 20 mg ORAL NDA authorized generic 19 sections
ATORVASTATIN CALCIUM HUMAN PRESCRIPTION DRUG LABEL 1 0179-0216 TABLET, FILM COATED 10 mg ORAL NDA authorized generic 19 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3950 TABLET, FILM COATED 10 mg ORAL ANDA 18 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3951 TABLET, FILM COATED 20 mg ORAL ANDA 18 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3952 TABLET, FILM COATED 40 mg ORAL ANDA 18 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3953 TABLET, FILM COATED 80 mg ORAL ANDA 18 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4510 TABLET, FILM COATED 10 mg ORAL ANDA 18 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4511 TABLET, FILM COATED 20 mg ORAL ANDA 18 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4512 TABLET, FILM COATED 40 mg ORAL ANDA 18 sections