atorvastatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 257 134523-00-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CI-981
  • CI981
  • atorvastatin calcium hydrate
  • atorvastatin calcium anhydrous
  • atorvastatin
  • atorvastatin acid
  • cardyl
  • atorvastatin calcium
  • atorvastatin calcium trihydrate
A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.
  • Molecular weight: 558.65
  • Formula: C33H35FN2O5
  • CLOGP: 4.46
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 4
  • TPSA: 111.79
  • ALOGS: -5.95
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.05 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.02 mg/mL Hosey CM, Chan R, Benet LZ
EoM (Fraction excreted unchanged in urine) 1 % Hosey CM, Chan R, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Dec. 17, 1996 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1150.54 9.88 2500 323625 121819 50157180
Maternal exposure during pregnancy 826.90 9.88 51 326074 159727 50119272
Rhabdomyolysis 778.72 9.88 1102 325023 37925 50241074
Immune-mediated myositis 744.55 9.88 273 325852 772 50278227
Pemphigus 717.51 9.88 11 326114 120155 50158844
Drug ineffective 661.53 9.88 2883 323242 816450 49462549
Systemic lupus erythematosus 552.74 9.88 116 326009 140506 50138493
Exposure during pregnancy 551.68 9.88 66 326059 120949 50158050
Hand deformity 543.31 9.88 24 326101 100175 50178824
Glossodynia 534.38 9.88 60 326065 115509 50163490
Contraindicated product administered 516.07 9.88 159 325966 148799 50130200
Acute kidney injury 458.52 9.88 2771 323354 225287 50053712
Treatment failure 455.51 9.88 159 325966 137478 50141521
Cerebrovascular accident 439.16 9.88 1476 324649 93204 50185795
Anti-cyclic citrullinated peptide antibody positive 432.28 9.88 4 326121 70583 50208416
Synovitis 431.19 9.88 131 325994 123734 50155265
Myocardial infarction 398.90 9.88 1372 324753 87655 50191344
Myopathy 383.80 9.88 378 325747 8761 50270238
Therapeutic product effect decreased 361.65 9.88 214 325911 135836 50143163
Infusion related reaction 355.47 9.88 341 325784 169216 50109783
Blood creatine phosphokinase increased 352.75 9.88 620 325505 25747 50253252
Off label use 343.86 9.88 1732 324393 472694 49806305
Pericarditis 334.73 9.88 53 326072 78636 50200363
Wound 333.52 9.88 132 325993 105662 50173337
Rheumatoid factor positive 295.66 9.88 5 326120 49854 50229145
Arthropathy 292.63 9.88 352 325773 157554 50121445
Drug intolerance 279.40 9.88 624 325501 218480 50060519
Muscular weakness 260.76 9.88 1258 324867 93755 50185244
Completed suicide 256.23 9.88 283 325842 131606 50147393
Duodenal ulcer perforation 243.68 9.88 12 326113 45599 50233400
Swelling 238.54 9.88 594 325531 200278 50078721
Alopecia 235.41 9.88 801 325324 244246 50034753
Necrotising myositis 229.65 9.88 88 326037 292 50278707
Acute myocardial infarction 228.44 9.88 551 325574 28722 50250277
Drug hypersensitivity 228.18 9.88 2547 323578 248463 50030536
Discomfort 223.50 9.88 221 325904 108159 50170840
Product use issue 216.66 9.88 395 325730 149080 50129919
Rheumatoid arthritis 214.18 9.88 634 325491 201916 50077083
Drug interaction 209.72 9.88 2086 324039 197535 50081464
Joint swelling 208.60 9.88 843 325282 244443 50034556
Abdominal discomfort 205.98 9.88 782 325343 230859 50048140
Coronary artery disease 205.18 9.88 534 325591 29192 50249807
Hypersensitivity 204.09 9.88 707 325418 214454 50064545
Helicobacter infection 199.30 9.88 39 326086 49663 50229336
Pain 196.44 9.88 2593 323532 576310 49702689
Muscle spasms 189.52 9.88 1422 324703 124131 50154868
Folliculitis 184.70 9.88 19 326106 39206 50239793
Hypomagnesaemia 175.48 9.88 431 325694 22725 50256274
Fall 168.06 9.88 3061 323064 331871 49947128
Toxicity to various agents 154.93 9.88 773 325352 211726 50067273
Blood glucose increased 153.40 9.88 883 325242 70441 50208558
Polymyositis 152.53 9.88 106 326019 1474 50277525
Sleep disorder due to general medical condition, insomnia type 148.66 9.88 15 326110 31432 50247567
Hypoglycaemia 145.15 9.88 707 325418 52874 50226125
Rash 143.17 9.88 1973 324152 435498 49843501
Hyponatraemia 142.28 9.88 1084 325041 95055 50183944
Stomatitis 138.74 9.88 277 325848 101067 50177932
Hyperkalaemia 137.85 9.88 645 325480 47444 50231555
Infection 137.29 9.88 610 325515 172344 50106655
Lactic acidosis 137.17 9.88 500 325625 32855 50246144
Irritable bowel syndrome 135.06 9.88 82 326043 51359 50227640
Abortion spontaneous 131.77 9.88 52 326073 41720 50237279
Febrile neutropenia 131.09 9.88 270 325855 97397 50181602
Transient ischaemic attack 130.91 9.88 481 325644 31729 50247270
Impaired healing 130.83 9.88 154 325971 69632 50209367
Pregnancy 130.18 9.88 18 326107 29559 50249440
Foetal exposure during pregnancy 126.89 9.88 14 326111 27345 50251654
Device expulsion 125.78 9.88 18 326107 28804 50250195
Chest pain 120.25 9.88 1701 324424 175181 50103818
Cardiac failure congestive 112.53 9.88 929 325196 83453 50195546
Atrial fibrillation 112.42 9.88 1075 325050 100670 50178329
Angina pectoris 112.30 9.88 398 325727 25790 50253209
Drug abuse 112.25 9.88 132 325993 59714 50219285
Cholestasis 111.48 9.88 389 325736 25012 50253987
Muscle injury 110.96 9.88 50 326075 37061 50241938
Hepatic enzyme increased 109.31 9.88 484 325641 136896 50142103
Sinusitis 109.06 9.88 648 325477 169910 50109089
Low density lipoprotein increased 108.95 9.88 157 325968 5489 50273510
Ischaemic stroke 108.51 9.88 285 325840 15663 50263336
Hypertensive emergency 106.37 9.88 85 326040 1478 50277521
Asthenia 103.04 9.88 2738 323387 316304 49962695
Drug-induced liver injury 102.19 9.88 405 325720 27690 50251309
Hemiplegia 101.86 9.88 176 325949 7205 50271794
Liver function test abnormal 98.64 9.88 554 325571 43785 50235214
Neurologic neglect syndrome 96.48 9.88 78 326047 1380 50277619
Autoimmune hepatitis 95.65 9.88 173 325952 7346 50271653
Angina unstable 93.98 9.88 161 325964 6545 50272454
Diabetic ketoacidosis 93.01 9.88 290 325835 17582 50261417
Myositis 92.93 9.88 176 325949 7744 50271255
Carotid artery thrombosis 92.50 9.88 77 326048 1422 50277577
Rheumatic fever 88.32 9.88 5 326120 16862 50262137
Pyrexia 88.18 9.88 1825 324300 378378 49900621
Gastrointestinal haemorrhage 87.16 9.88 787 325338 72534 50206465
Intentional overdose 86.24 9.88 170 325955 62334 50216665
Ill-defined disorder 84.98 9.88 138 325987 54516 50224483
Syncope 84.77 9.88 1026 325099 101976 50177023
Premature delivery 84.14 9.88 24 326101 23639 50255360
Neutropenia 83.93 9.88 583 325542 147382 50131617
Caesarean section 83.89 9.88 4 326121 15635 50263364
Malignant neoplasm progression 83.45 9.88 198 325927 67926 50211073
Swollen joint count increased 82.47 9.88 3 326122 14870 50264129
Dizziness 82.37 9.88 2863 323262 343506 49935493
Premature baby 81.07 9.88 11 326114 18326 50260673
Coronary artery occlusion 81.04 9.88 161 325964 7342 50271657
Renal failure 78.73 9.88 1041 325084 105592 50173407
Live birth 77.10 9.88 8 326117 16400 50262599
Condition aggravated 76.70 9.88 1400 324725 295658 49983341
Anaemia 75.59 9.88 2146 323979 250310 50028689
Melaena 75.27 9.88 358 325767 26506 50252493
Intentional product use issue 74.66 9.88 250 325875 76668 50202331
C-reactive protein increased 72.38 9.88 205 325920 66269 50212730
Adjustment disorder 71.15 9.88 76 326049 1943 50277056
Hepatocellular injury 69.26 9.88 341 325784 25606 50253393
Gastrointestinal disorder 69.08 9.88 343 325782 94113 50184886
Myocardial ischaemia 68.53 9.88 197 325928 11416 50267583
Acute coronary syndrome 68.40 9.88 172 325953 9202 50269797
Rectal haemorrhage 68.18 9.88 454 325671 38104 50240895
Hepatitis cholestatic 68.17 9.88 133 325992 5984 50273015
Glycosylated haemoglobin increased 67.58 9.88 185 325940 10421 50268578
Blister 66.66 9.88 303 325822 85115 50193884
Cerebral haemorrhage 66.24 9.88 347 325778 26705 50252294
Bradycardia 64.96 9.88 668 325457 63758 50215241
Product use in unapproved indication 64.35 9.88 459 325666 115360 50163639
Hip arthroplasty 63.90 9.88 61 326064 30368 50248631
Intentional self-injury 63.28 9.88 35 326090 23077 50255922
Pemphigoid 62.89 9.88 126 325999 5781 50273218
Pancreatitis acute 62.18 9.88 311 325814 23501 50255498
Coronary artery stenosis 61.46 9.88 104 326021 4185 50274814
Macular degeneration 60.26 9.88 217 325908 14171 50264828
Diabetes mellitus 60.16 9.88 530 325595 48503 50230496
Cardiac disorder 59.87 9.88 478 325647 42501 50236498
Renal impairment 59.35 9.88 747 325378 74914 50204085
Hepatitis 59.06 9.88 376 325749 31077 50247922
Atrioventricular block 58.29 9.88 129 325996 6349 50272650
Labelled drug-drug interaction medication error 58.25 9.88 174 325951 10303 50268696
Incorrect dosage administered 57.74 9.88 63 326062 1651 50277348
Jaundice 57.31 9.88 328 325797 26101 50252898
Decreased appetite 57.08 9.88 1697 324428 199226 50079773
Dysarthria 56.55 9.88 424 325701 36979 50242020
Blood triglycerides increased 56.52 9.88 181 325944 11131 50267868
Nasopharyngitis 55.97 9.88 890 325235 192037 50086962
Hepatitis acute 55.93 9.88 144 325981 7817 50271182
Injection site erythema 55.43 9.88 271 325854 74665 50204334
Chromaturia 55.22 9.88 213 325912 14377 50264622
Personality disorder 54.38 9.88 99 326026 4225 50274774
Injection site reaction 53.94 9.88 155 325970 49877 50229122
Knee arthroplasty 52.52 9.88 94 326031 35752 50243247
Diabetes mellitus inadequate control 52.31 9.88 195 325930 12950 50266049
Chronic kidney disease 51.99 9.88 436 325689 39335 50239664
Musculoskeletal stiffness 51.89 9.88 553 325572 127928 50151071
International normalised ratio increased 51.17 9.88 463 325662 42689 50236310
Leukopenia 50.64 9.88 243 325882 67285 50211714
Neurotoxicity 50.50 9.88 16 326109 14724 50264275
Red blood cell sedimentation rate abnormal 50.47 9.88 21 326104 16322 50262677
Haematochezia 50.44 9.88 434 325691 39448 50239551
Cardiac failure 49.10 9.88 725 325400 75315 50203684
Swollen tongue 48.76 9.88 334 325791 28296 50250703
Mixed liver injury 48.55 9.88 83 326042 3368 50275631
Pain in extremity 48.05 9.88 2184 323941 270681 50008318
Oedema peripheral 47.55 9.88 1344 324781 156617 50122382
Lower respiratory tract infection 46.90 9.88 390 325735 94811 50184188
Injection site swelling 46.82 9.88 127 325998 41646 50237353
Injection site pain 46.82 9.88 473 325652 110551 50168448
Atrioventricular block complete 46.67 9.88 127 325998 7128 50271871
Drug resistance 46.14 9.88 33 326092 18956 50260043
Carotid arteriosclerosis 46.14 9.88 43 326082 928 50278071
Premature labour 46.01 9.88 9 326116 11467 50267532
Amnesia 45.89 9.88 445 325680 41815 50237184
Autoimmune myositis 45.21 9.88 18 326107 68 50278931
Bone erosion 45.13 9.88 10 326115 11677 50267322
Suicide attempt 44.99 9.88 176 325949 51556 50227443
Device dislocation 44.30 9.88 44 326081 21502 50257497
Dehydration 44.20 9.88 1291 324834 151158 50127841
Labile blood pressure 44.12 9.88 54 326071 1606 50277393
Muscle necrosis 44.00 9.88 32 326093 480 50278519
Polymyalgia rheumatica 43.31 9.88 68 326057 2568 50276431
Dementia 43.24 9.88 211 325914 15786 50263213
Cytomegalovirus infection 42.62 9.88 32 326093 17930 50261069
Blood alkaline phosphatase increased 41.66 9.88 397 325728 37129 50241870
Hemiparesis 41.64 9.88 246 325879 19802 50259197
Muscle atrophy 41.24 9.88 109 326016 6012 50272987
Carotid artery stenosis 41.21 9.88 93 326032 4638 50274361
Therapeutic product effect incomplete 41.06 9.88 384 325741 91131 50187868
Large intestine polyp 40.98 9.88 122 326003 7210 50271789
Accidental exposure to product 40.97 9.88 53 326072 23004 50255995
Myelosuppression 40.74 9.88 18 326107 13499 50265500
Chronic obstructive pulmonary disease 39.97 9.88 523 325602 52912 50226087
Blood loss anaemia 39.55 9.88 129 325996 8010 50270989
Infective pulmonary exacerbation of cystic fibrosis 39.48 9.88 3 326122 7906 50271093
Hyperglycaemia 39.36 9.88 383 325742 36022 50242977
Coma 39.06 9.88 211 325914 56668 50222331
Hepatitis toxic 38.66 9.88 67 326058 2749 50276250
Haemorrhage intracranial 38.44 9.88 170 325955 12204 50266795
Sensory loss 37.92 9.88 123 326002 7615 50271384
Therapeutic response decreased 37.77 9.88 166 325959 47065 50231934
Pre-eclampsia 37.60 9.88 4 326121 8040 50270959
Vascular stent stenosis 37.43 9.88 29 326096 481 50278518
Blood pressure increased 37.38 9.88 1123 325002 132009 50146990
Psoriatic arthropathy 37.18 9.88 166 325959 46866 50232133
Product monitoring error 36.96 9.88 65 326060 2699 50276300
Pancytopenia 36.67 9.88 355 325770 83675 50195324
Mucosal inflammation 36.57 9.88 134 325991 40008 50238991
Haematoma 36.50 9.88 328 325797 30182 50248817
Gamma-glutamyltransferase increased 36.23 9.88 320 325805 29303 50249696
Low density lipoprotein abnormal 36.20 9.88 19 326106 152 50278847
Aphasia 35.99 9.88 310 325815 28184 50250815
Cholestatic liver injury 35.82 9.88 54 326071 1967 50277032
Dyspnoea 35.45 9.88 4038 322087 543570 49735429
Blood cholesterol abnormal 35.19 9.88 57 326068 2211 50276788
Blood glucose decreased 34.99 9.88 219 325906 17992 50261007
Gait disturbance 34.80 9.88 1237 324888 148768 50130231
Respiratory depression 34.64 9.88 17 326108 11993 50267006
Haematemesis 34.16 9.88 300 325825 27425 50251574
Mitral valve incompetence 34.13 9.88 211 325914 17260 50261739
Abortion induced 34.12 9.88 9 326116 9335 50269664
Hypocalcaemia 34 9.88 292 325833 26524 50252475
Panniculitis 33.40 9.88 7 326118 8496 50270503
Neutrophil count decreased 33.14 9.88 168 325957 45858 50233141
Upper gastrointestinal haemorrhage 32.81 9.88 196 325929 15839 50263160
Motor dysfunction 32.68 9.88 120 326005 7911 50271088
Weight decreased 32.67 9.88 1741 324384 219504 50059495
Arteriosclerosis 32.32 9.88 130 325995 8947 50270052
Peripheral artery stenosis 32.28 9.88 27 326098 502 50278497
Body height decreased 32.05 9.88 128 325997 8780 50270219
Myocardial necrosis marker increased 31.67 9.88 44 326081 1486 50277513
Product substitution issue 31.49 9.88 176 325949 13881 50265118
Eosinophilia 31.40 9.88 217 325908 18435 50260564
Euglycaemic diabetic ketoacidosis 31.06 9.88 61 326064 2758 50276241
Ischaemic cardiomyopathy 30.44 9.88 54 326071 2258 50276741
Tenosynovitis 30.40 9.88 15 326110 10550 50268449
Cerebral infarction 29.93 9.88 240 325885 21364 50257635
Muscle disorder 29.86 9.88 78 326047 4272 50274727
Subdural haematoma 29.60 9.88 163 325962 12784 50266215
High density lipoprotein decreased 29.53 9.88 45 326080 1655 50277344
Myoglobin blood increased 29.53 9.88 39 326086 1254 50277745
Myopathy toxic 29.46 9.88 23 326102 386 50278613
Confusional state 29.46 9.88 1473 324652 184455 50094544
Disease progression 29.20 9.88 438 325687 95428 50183571
Dermatomyositis 29.13 9.88 51 326074 2110 50276889
Liver disorder 28.54 9.88 366 325759 36856 50242143
Blood creatine phosphokinase MB increased 28.51 9.88 36 326089 1106 50277893
Diabetic metabolic decompensation 28.33 9.88 41 326084 1439 50277560
Respiratory arrest 28.12 9.88 99 326026 29910 50249089
Fibromyalgia 28.11 9.88 172 325953 44806 50234193
Mobility decreased 28.03 9.88 355 325770 79593 50199406
Uterine perforation 28.00 9.88 4 326121 6411 50272588
Angioedema 27.85 9.88 368 325757 37308 50241691
Foetal death 27.81 9.88 9 326116 8171 50270828
Inappropriate antidiuretic hormone secretion 27.76 9.88 162 325963 12981 50266018
Aldolase increased 27.67 9.88 15 326110 129 50278870
Migraine 27.63 9.88 331 325794 74949 50204050
Eating disorder 27.57 9.88 182 325943 15227 50263772
Aortic stenosis 27.56 9.88 74 326051 4120 50274879
Febrile bone marrow aplasia 27.40 9.88 4 326121 6307 50272692
Rheumatoid nodule 27.36 9.88 25 326100 12710 50266289
Diabetic retinopathy 27.03 9.88 50 326075 2160 50276839
Hypokalaemia 26.82 9.88 750 325375 87242 50191757
Oligohydramnios 26.52 9.88 3 326122 5747 50273252
Incorrect route of product administration 26.41 9.88 50 326075 18616 50260383
Enthesopathy 26.13 9.88 7 326118 7186 50271813
Intestinal haemorrhage 26.03 9.88 61 326064 3119 50275880
Affect lability 26.00 9.88 121 326004 8877 50270122
Hepatic function abnormal 25.76 9.88 323 325802 32358 50246641
Mouth swelling 25.64 9.88 69 326056 3847 50275152
Urinary tract discomfort 25.62 9.88 17 326108 218 50278781
Injection site pruritus 25.54 9.88 154 325971 40257 50238742
Angiopathy 25.37 9.88 71 326054 4051 50274948
Flatulence 25.33 9.88 296 325829 29162 50249837
Stillbirth 25.32 9.88 4 326121 5948 50273051
Renal disorder 25.29 9.88 280 325845 27225 50251774
Head injury 25.13 9.88 251 325874 23769 50255230
Cell death 24.49 9.88 48 326077 2167 50276832
Device issue 24.49 9.88 58 326067 19914 50259085
Amenorrhoea 24.48 9.88 12 326113 8472 50270527
Lichen planopilaris 24.31 9.88 6 326119 0 50278999
Traumatic coma 24.29 9.88 11 326114 61 50278938
Hyperlipidaemia 24.07 9.88 194 325931 17296 50261703
Anuria 24.02 9.88 139 325986 11105 50267894
Post viral fatigue syndrome 23.99 9.88 18 326107 284 50278715
Metastases to bone 23.91 9.88 50 326075 17945 50261054
Hepatic ischaemia 23.52 9.88 24 326101 581 50278418
Acute myeloid leukaemia 23.48 9.88 38 326087 15036 50263963
Loss of personal independence in daily activities 23.47 9.88 314 325811 69736 50209263
Hypovolaemic shock 23.23 9.88 80 326045 5108 50273891
Dysphagia 23.14 9.88 659 325466 76859 50202140
Poisoning deliberate 23.12 9.88 11 326114 7901 50271098
Alanine aminotransferase increased 23.10 9.88 739 325386 87620 50191379
Hypertensive cardiomyopathy 23.10 9.88 15 326110 185 50278814
Stent placement 22.94 9.88 61 326064 3377 50275622
Faeces discoloured 22.82 9.88 180 325945 15944 50263055
Food allergy 22.75 9.88 12 326113 8125 50270874
Retinal artery occlusion 22.57 9.88 37 326088 1450 50277549
Maternal drugs affecting foetus 22.55 9.88 3 326122 5074 50273925
Immunodeficiency 22.52 9.88 38 326087 14790 50264209
Embolic stroke 22.42 9.88 61 326064 3423 50275576
Malaise 22.29 9.88 2479 323646 333053 49945946
Hypovolaemia 22.20 9.88 120 326005 9345 50269654
Therapeutic drug monitoring analysis not performed 22.17 9.88 25 326100 680 50278319
Hypertransaminasaemia 22.03 9.88 62 326063 3549 50275450
Cardiotoxicity 21.75 9.88 9 326116 7018 50271981
Suicidal ideation 21.69 9.88 240 325885 55145 50223854
Carotid artery occlusion 21.58 9.88 49 326076 2454 50276545
Haematotoxicity 21.55 9.88 12 326113 7883 50271116
Mydriasis 21.51 9.88 22 326103 10605 50268394
Myoglobinuria 21.35 9.88 16 326109 252 50278747
Seizure 21.35 9.88 587 325538 117287 50161712
Peripheral nerve palsy 21.09 9.88 7 326118 13 50278986
Arterial stenosis 21.09 9.88 22 326103 547 50278452
Psychotic disorder 21.08 9.88 71 326054 21741 50257258
Device related infection 21.08 9.88 66 326059 20669 50258330
Antimitochondrial antibody positive 21.04 9.88 10 326115 63 50278936
Cardiac murmur 20.92 9.88 130 325995 10654 50268345
Ankylosing spondylitis 20.88 9.88 10 326115 7155 50271844
Interstitial lung disease 20.88 9.88 469 325656 52707 50226292
Heavy menstrual bleeding 20.79 9.88 43 326082 15494 50263505
Sedation 20.76 9.88 114 326011 30496 50248503
Hepatic steatosis 20.52 9.88 244 325881 24140 50254859
Cerebral haematoma 20.45 9.88 56 326069 3155 50275844
Rectal polyp 20.44 9.88 28 326097 933 50278066
Pancreatitis 20.39 9.88 387 325738 42227 50236772
Grip strength decreased 20.38 9.88 29 326096 12092 50266907
Subarachnoid haemorrhage 20.34 9.88 129 325996 10647 50268352
Aspartate aminotransferase increased 20.30 9.88 652 325473 77346 50201653
Unintentional medical device removal 20.29 9.88 5 326120 5430 50273569
Arthralgia 20.13 9.88 2498 323627 436204 49842795
Diverticulum 19.99 9.88 127 325998 10487 50268512
Complication of device insertion 19.92 9.88 7 326118 6034 50272965
Glomerular filtration rate decreased 19.87 9.88 136 325989 11516 50267483
Urinary tract infection 19.84 9.88 1689 324436 222331 50056668
Cervix neoplasm 19.83 9.88 14 326111 200 50278799
Urine output decreased 19.82 9.88 125 326000 10296 50268703
Spinal epidural haematoma 19.82 9.88 28 326097 961 50278038
Pathogen resistance 19.80 9.88 6 326119 5683 50273316
Chloropsia 19.74 9.88 8 326117 32 50278967
Ocular myasthenia 19.72 9.88 12 326113 131 50278868
Arterial occlusive disease 19.70 9.88 72 326053 4736 50274263
Coronary artery thrombosis 19.61 9.88 29 326096 1038 50277961
Pulmonary renal syndrome 19.56 9.88 18 326107 382 50278617
Hepatorenal syndrome 19.55 9.88 38 326087 1705 50277294
Dysgeusia 19.52 9.88 356 325769 38560 50240439
Urinary tract obstruction 19.47 9.88 38 326087 1710 50277289
Presyncope 19.43 9.88 240 325885 23958 50255041
Transplant rejection 19.32 9.88 20 326105 9589 50269410
Coronary artery restenosis 19.30 9.88 17 326108 340 50278659
Eructation 19.30 9.88 94 326031 7027 50271972
Haematuria 19.28 9.88 251 325874 25362 50253637
Calcium deficiency 19.19 9.88 27 326098 923 50278076
Tuberculosis 19.16 9.88 22 326103 10061 50268938
Balance disorder 19.14 9.88 593 325532 69997 50209002
Gastrointestinal toxicity 19.13 9.88 70 326055 4607 50274392
Metastases to liver 19.05 9.88 66 326059 20038 50258961
Dysstasia 19.03 9.88 187 325938 17632 50261367
Memory impairment 19.02 9.88 657 325468 78703 50200296
Overdose 19.00 9.88 493 325632 99234 50179765
Metastases to central nervous system 18.96 9.88 27 326098 11255 50267744
Left atrial enlargement 18.91 9.88 15 326110 258 50278741
Lip swelling 18.86 9.88 243 325882 24493 50254506
Coronary artery bypass 18.79 9.88 44 326081 2249 50276750
Duodenal ulcer 18.77 9.88 90 326035 6685 50272314
Poisoning 18.74 9.88 32 326093 12397 50266602
Gastric ulcer 18.73 9.88 215 325910 21090 50257909
Coordination abnormal 18.72 9.88 133 325992 11401 50267598
Subacute cutaneous lupus erythematosus 18.69 9.88 43 326082 2172 50276827
Adverse drug reaction 18.69 9.88 247 325878 54975 50224024
Diabetic nephropathy 18.57 9.88 32 326093 1307 50277692
Blood urea increased 18.54 9.88 233 325892 23352 50255647
Multiple sclerosis relapse 18.53 9.88 182 325943 42782 50236217
Haemophagocytic lymphohistiocytosis 18.48 9.88 17 326108 8616 50270383
Vertigo 18.46 9.88 451 325674 51381 50227618
Arteriovenous fistula occlusion 18.43 9.88 17 326108 362 50278637
Albuminuria 18.39 9.88 13 326112 186 50278813
Periorbital haematoma 18.28 9.88 23 326102 704 50278295
Orthostatic hypotension 18.21 9.88 279 325846 29202 50249797
Bone marrow failure 18.13 9.88 104 326021 27520 50251479
Peripheral arterial occlusive disease 18.04 9.88 57 326068 3480 50275519
Hallucination, gustatory 18.03 9.88 9 326116 64 50278935
Blood creatinine increased 17.88 9.88 629 325496 75531 50203468
Lymphocyte count decreased 17.83 9.88 98 326027 26209 50252790
Aspergillus infection 17.72 9.88 11 326114 6810 50272189
Inflammation 17.68 9.88 259 325866 56653 50222346
Stevens-Johnson syndrome 17.66 9.88 76 326049 21676 50257323
Abnormal loss of weight 17.61 9.88 72 326053 4992 50274007
Vascular stent occlusion 17.57 9.88 8 326117 45 50278954
Ventricular hypertrophy 17.50 9.88 53 326072 3162 50275837
Muscle relaxant therapy 17.44 9.88 12 326113 164 50278835
Candida infection 17.42 9.88 85 326040 23438 50255561
Ketoacidosis 17.39 9.88 60 326065 3835 50275164
Blood creatine phosphokinase abnormal 17.38 9.88 13 326112 204 50278795
Haemorrhagic transformation stroke 17.38 9.88 28 326097 1081 50277918
Dysuria 17.31 9.88 269 325856 28235 50250764
Intermittent claudication 17.26 9.88 35 326090 1620 50277379
Psoriasis 17.24 9.88 574 325551 68426 50210573
Epstein-Barr virus infection 17.21 9.88 12 326113 6985 50272014
Subchondral insufficiency fracture 17.02 9.88 8 326117 49 50278950
Cardiac failure acute 16.98 9.88 101 326024 8149 50270850
Pallor 16.90 9.88 226 325899 22973 50256026
Lipoprotein (a) increased 16.90 9.88 7 326118 30 50278969
Coronary artery surgery 16.88 9.88 8 326117 50 50278949
Neurosensory hypoacusis 16.86 9.88 13 326112 214 50278785
Acne 16.82 9.88 67 326058 19528 50259471
Epistaxis 16.74 9.88 535 325590 63419 50215580
Acidosis 16.64 9.88 118 326007 10109 50268890
Blood iron decreased 16.62 9.88 130 325995 11485 50267514
Carotid artery disease 16.59 9.88 33 326092 1506 50277493
Diverticulum intestinal 16.57 9.88 79 326046 5854 50273145
Dyspnoea exertional 16.54 9.88 440 325685 50793 50228206
Product prescribing error 16.44 9.88 207 325918 20754 50258245
Pollakiuria 16.41 9.88 230 325895 23621 50255378
Menstrual disorder 16.36 9.88 4 326121 4366 50274633
Spur cell anaemia 16.35 9.88 6 326119 17 50278982
Electrocardiogram abnormal 16.23 9.88 94 326031 7511 50271488
Cholangiolitis 16.20 9.88 4 326121 0 50278999
Tongue oedema 16.16 9.88 58 326067 3781 50275218
Death 16.13 9.88 1843 324282 323536 49955463
Microcytic anaemia 16.01 9.88 50 326075 3034 50275965
Fatigue 16.00 9.88 4186 321939 703415 49575584
Low birth weight baby 15.96 9.88 9 326116 5872 50273127
Large intestinal haemorrhage 15.95 9.88 28 326097 1161 50277838
Ear congestion 15.94 9.88 38 326087 1965 50277034
Menstruation irregular 15.92 9.88 10 326115 6152 50272847
Sinus bradycardia 15.90 9.88 142 325983 13041 50265958
Joint destruction 15.85 9.88 3 326122 3913 50275086
Blood electrolytes abnormal 15.85 9.88 25 326100 948 50278051
Abnormal dreams 15.73 9.88 109 326016 9268 50269731
Device adhesion issue 15.67 9.88 3 326122 3882 50275117
Renal injury 15.59 9.88 102 326023 8509 50270490
Prothrombin consumption time prolonged 15.58 9.88 7 326118 38 50278961
Cerebral microangiopathy 15.58 9.88 13 326112 241 50278758
Electrocardiogram QT prolonged 15.45 9.88 441 325684 51445 50227554
Tumour lysis syndrome 15.43 9.88 15 326110 7406 50271593
Device difficult to use 15.33 9.88 25 326100 9861 50269138
Lower gastrointestinal haemorrhage 15.32 9.88 86 326039 6793 50272206
Blood parathyroid hormone decreased 15.24 9.88 14 326111 7100 50271899
Transaminases increased 15.19 9.88 258 325867 27566 50251433
Polyuria 15.19 9.88 88 326037 7033 50271966
Red blood cell sedimentation rate increased 15.17 9.88 119 326006 29297 50249702
Saliva altered 15.14 9.88 14 326111 299 50278700
Blood lactic acid 15.13 9.88 9 326116 94 50278905
Muscle enzyme increased 15.09 9.88 10 326115 128 50278871
Progressive multifocal leukoencephalopathy 15.08 9.88 32 326093 11425 50267574
Glomerular filtration rate abnormal 15.03 9.88 18 326107 523 50278476
Electrolyte imbalance 14.98 9.88 173 325952 16996 50262003
Creatinine renal clearance decreased 14.97 9.88 34 326091 11847 50267152
Jaundice cholestatic 14.96 9.88 69 326056 5042 50273957
Injection site warmth 14.91 9.88 43 326082 13823 50265176
Diabetic neuropathy 14.90 9.88 54 326071 3537 50275462
Hypervolaemia 14.87 9.88 239 325886 25260 50253739
Pulmonary toxicity 14.77 9.88 73 326052 5489 50273510
Musculoskeletal chest pain 14.69 9.88 183 325942 18303 50260696
Acute left ventricular failure 14.64 9.88 22 326103 799 50278200
Blood creatinine abnormal 14.64 9.88 44 326081 2614 50276385
Thrombocytopenia 14.58 9.88 673 325452 127000 50151999
C-reactive protein abnormal 14.57 9.88 112 326013 27697 50251302
Ventricular septal defect 14.55 9.88 4 326121 4037 50274962
Thyroid disorder 14.51 9.88 135 325990 12542 50266457
Haemorrhagic cyst 14.48 9.88 11 326114 177 50278822
Aplastic anaemia 14.43 9.88 17 326108 7686 50271313
Macular oedema 14.37 9.88 54 326071 3600 50275399
Cataract 14.36 9.88 403 325722 46897 50232102
Diarrhoea 14.35 9.88 4125 322000 584351 49694648
Chest wall haematoma 14.32 9.88 11 326114 180 50278819
Alveolar osteitis 14.31 9.88 16 326109 431 50278568
Arterial insufficiency 14.27 9.88 10 326115 141 50278858
Feeling abnormal 14.25 9.88 965 325160 124527 50154472
Generalised tonic-clonic seizure 14.24 9.88 105 326020 26205 50252794
Blood pressure inadequately controlled 14.24 9.88 61 326064 4319 50274680
Muscle fatigue 14.21 9.88 39 326086 2200 50276799
Blood sodium decreased 14.18 9.88 203 325922 20944 50258055
Oral herpes 14.16 9.88 77 326048 20648 50258351
Blood cholesterol decreased 14.13 9.88 21 326104 755 50278244
Urinary occult blood positive 14.12 9.88 7 326118 49 50278950
Back pain 14.08 9.88 1622 324503 218408 50060591
Bacteraemia 13.94 9.88 47 326078 14386 50264613
Hypertension 13.93 9.88 1560 324565 209643 50069356
Hypocapnia 13.85 9.88 14 326111 335 50278664
Blue toe syndrome 13.81 9.88 15 326110 391 50278608
Faeces pale 13.77 9.88 30 326095 1461 50277538
Hypoacusis 13.77 9.88 198 325927 20449 50258550
Jaundice hepatocellular 13.75 9.88 6 326119 30 50278969
Sedation complication 13.75 9.88 22 326103 8744 50270255
Onychomadesis 13.71 9.88 3 326122 3533 50275466
Joint range of motion decreased 13.65 9.88 67 326058 18445 50260554
Disorientation 13.62 9.88 312 325813 35172 50243827
Hypertensive angiopathy 13.57 9.88 8 326117 82 50278917
Tobacco abuse 13.55 9.88 18 326107 582 50278417
Palmar-plantar erythrodysaesthesia syndrome 13.55 9.88 75 326050 20023 50258976
Arteriosclerosis coronary artery 13.55 9.88 90 326035 7546 50271453
Ligament sprain 13.55 9.88 115 326010 10410 50268589
Cardio-respiratory arrest 13.54 9.88 255 325870 53637 50225362
Administration site discomfort 13.49 9.88 8 326117 83 50278916
Device deployment issue 13.48 9.88 3 326122 3493 50275506
Bladder sphincter atony 13.48 9.88 10 326115 155 50278844
Biliary fibrosis 13.46 9.88 4 326121 4 50278995
Copper metabolism disorder 13.46 9.88 4 326121 4 50278995
Multiple injuries 13.43 9.88 32 326093 1654 50277345
Hypophagia 13.33 9.88 252 325873 27476 50251523
Cardiac operation 13.31 9.88 44 326081 2751 50276248
Staphylococcal infection 13.29 9.88 156 325969 35460 50243539
Peripheral vascular disorder 13.29 9.88 70 326055 5397 50273602
Cytokine release syndrome 13.23 9.88 22 326103 8612 50270387
Cerebral mass effect 13.22 9.88 21 326104 801 50278198
Internal haemorrhage 13.21 9.88 60 326065 4357 50274642
Hypotension 13.14 9.88 1721 324404 233748 50045251
Blood calcium increased 13.11 9.88 90 326035 7629 50271370
Flushing 13.11 9.88 330 325795 66685 50212314
Hypertensive crisis 13.06 9.88 136 325989 13018 50265981
Vascular purpura 13.05 9.88 26 326099 1188 50277811
Neutropenic sepsis 13.03 9.88 47 326078 14100 50264899
High density lipoprotein abnormal 13.03 9.88 7 326118 59 50278940
Ecchymosis 13.03 9.88 111 326014 10058 50268941
Ventricular internal diameter abnormal 13.00 9.88 6 326119 35 50278964
Skin necrosis 12.97 9.88 32 326093 10835 50268164
Adverse event 12.96 9.88 201 325924 43562 50235437
Colitis ischaemic 12.95 9.88 105 326020 9378 50269621
Bronchopulmonary aspergillosis 12.93 9.88 18 326107 7574 50271425
Tubulointerstitial nephritis and uveitis syndrome 12.90 9.88 10 326115 166 50278833
Immune reconstitution inflammatory syndrome 12.87 9.88 10 326115 5506 50273493
Prevertebral soft tissue swelling of cervical space 12.86 9.88 6 326119 36 50278963
Injection site rash 12.84 9.88 57 326068 16120 50262879
Xanthelasma 12.84 9.88 7 326118 61 50278938
Low density lipoprotein decreased 12.83 9.88 11 326114 212 50278787
Mixed anxiety and depressive disorder 12.80 9.88 10 326115 168 50278831
Sinus node dysfunction 12.79 9.88 55 326070 3900 50275099
Neoplasm progression 12.79 9.88 123 326002 29034 50249965
Lipids abnormal 12.76 9.88 12 326113 262 50278737
Cardiac pacemaker insertion 12.75 9.88 52 326073 3601 50275398
Renovascular hypertension 12.74 9.88 5 326120 18 50278981
Gait deviation 12.74 9.88 7 326118 62 50278937
Weight increased 12.69 9.88 1124 325001 200767 50078232
Hypergammaglobulinaemia 12.69 9.88 15 326110 430 50278569
Cerebral ischaemia 12.59 9.88 73 326052 5835 50273164
Ageusia 12.58 9.88 122 326003 11461 50267538
Inclusion body myositis 12.58 9.88 4 326121 6 50278993
Blood iron abnormal 12.54 9.88 3 326122 3323 50275676
Myoglobinaemia 12.53 9.88 5 326120 19 50278980
Ear infection 12.50 9.88 107 326018 25863 50253136
Nail bed inflammation 12.50 9.88 14 326111 378 50278621
Blood potassium increased 12.47 9.88 161 325964 16237 50262762
Parkinsonian rest tremor 12.44 9.88 8 326117 97 50278902
Wrong dose 12.39 9.88 21 326104 846 50278153
IIIrd nerve paresis 12.38 9.88 9 326116 135 50278864
Diverticulum oesophageal 12.32 9.88 9 326116 136 50278863
Eyelid retraction 12.10 9.88 6 326119 42 50278957
Parkinsonism 12.10 9.88 98 326027 8749 50270250
Soft tissue disorder 12.10 9.88 6 326119 4208 50274791
Lung hyperinflation 12.08 9.88 24 326101 1094 50277905
N-terminal prohormone brain natriuretic peptide increased 12.08 9.88 31 326094 1679 50277320
Hypomania 12.08 9.88 7 326118 4498 50274501
Retroperitoneal haematoma 12.05 9.88 41 326084 2602 50276397
Acute respiratory distress syndrome 12.01 9.88 83 326042 21016 50257983
Chest discomfort 11.98 9.88 721 325404 92001 50186998
Mammogram abnormal 11.98 9.88 18 326107 654 50278345
Muscle contracture 11.97 9.88 25 326100 1182 50277817
Fear of injection 11.94 9.88 13 326112 6090 50272909
Ascites 11.92 9.88 161 325964 35700 50243299
Cholecystitis chronic 11.92 9.88 28 326097 9641 50269358
Posture abnormal 11.90 9.88 35 326090 2054 50276945
Muscle haemorrhage 11.87 9.88 44 326081 2914 50276085
Hyponatraemic seizure 11.82 9.88 14 326111 402 50278597
Serotonin syndrome 11.82 9.88 102 326023 24611 50254388
Albumin urine present 11.82 9.88 11 326114 237 50278762
Intra-abdominal haematoma 11.81 9.88 29 326096 1528 50277471
Genital haemorrhage 11.79 9.88 15 326110 6559 50272440
Lipohypertrophy 11.76 9.88 17 326108 596 50278403
Narrow anterior chamber angle 11.76 9.88 6 326119 45 50278954
Neurofibrosarcoma 11.73 9.88 9 326116 147 50278852
Granulomatous dermatitis 11.71 9.88 8 326117 108 50278891
Electrocardiogram Q wave abnormal 11.69 9.88 7 326118 74 50278925
Adenovirus infection 11.66 9.88 3 326122 3165 50275834
Basal ganglia haemorrhage 11.66 9.88 16 326109 534 50278465
Parapsoriasis 11.65 9.88 8 326117 109 50278890
Anal polyp 11.65 9.88 6 326119 46 50278953
Crystal urine 11.65 9.88 6 326119 46 50278953
White blood cell count decreased 11.63 9.88 624 325501 116098 50162901
Hallucination 11.62 9.88 388 325737 46269 50232730
Glucose urine present 11.62 9.88 18 326107 672 50278327
Dilatation atrial 11.62 9.88 32 326093 1809 50277190
Blood pressure systolic increased 11.60 9.88 305 325820 35144 50243855
Product complaint 11.60 9.88 119 326006 11347 50267652
Lipoma 11.60 9.88 35 326090 2084 50276915
Diabetic foot 11.58 9.88 26 326099 1292 50277707
Muscle rupture 11.57 9.88 35 326090 2087 50276912
Eye haemorrhage 11.57 9.88 84 326041 7251 50271748
Fine motor skill dysfunction 11.54 9.88 6 326119 4097 50274902
Gastroduodenal haemorrhage 11.54 9.88 7 326118 76 50278923
Injury 11.53 9.88 234 325891 48691 50230308
Cardiac discomfort 11.52 9.88 20 326105 822 50278177
Dyslipidaemia 11.50 9.88 72 326053 5916 50273083
Respiratory disorder 11.49 9.88 137 325988 31050 50247949
Vascular device infection 11.49 9.88 7 326118 4377 50274622
Deformity 11.47 9.88 21 326104 7919 50271080
Lacunar stroke 11.47 9.88 8 326117 112 50278887
Blood calcitonin increased 11.46 9.88 5 326120 25 50278974
Vascular graft 11.45 9.88 19 326106 752 50278247
Iron deficiency anaemia 11.45 9.88 162 325963 16672 50262327
Polyarthritis 11.42 9.88 21 326104 7906 50271093
Incision site haemorrhage 11.41 9.88 15 326110 480 50278519
Acute respiratory failure 11.34 9.88 254 325871 28528 50250471
Acute pulmonary oedema 11.33 9.88 83 326042 7184 50271815
Swelling face 11.27 9.88 430 325695 52165 50226834
Carotid bruit 11.24 9.88 17 326108 621 50278378
BRASH syndrome 11.23 9.88 10 326115 203 50278796
Dairy intolerance 11.23 9.88 6 326119 50 50278949
Myeloma cast nephropathy 11.17 9.88 8 326117 117 50278882
Tunnel vision 11.06 9.88 18 326107 701 50278298
Lymphomatoid papulosis 11.06 9.88 8 326117 119 50278880
Body temperature increased 11.04 9.88 139 325986 31202 50247797
Acute cutaneous lupus erythematosus 11.02 9.88 11 326114 259 50278740
Prolonged expiration 11.02 9.88 18 326107 703 50278296
Myelodysplastic syndrome 11.02 9.88 55 326070 15077 50263922
Arterial disorder 11.02 9.88 22 326103 1007 50277992
Palpitations 10.95 9.88 728 325397 93778 50185221
Cataract operation 10.95 9.88 54 326071 4057 50274942
Pulmonary oedema 10.95 9.88 402 325723 48536 50230463
Dementia Alzheimer's type 10.94 9.88 22 326103 1012 50277987
Connective tissue inflammation 10.93 9.88 6 326119 53 50278946
Hyperprolactinaemia 10.93 9.88 4 326121 3361 50275638
Vascular stenosis 10.92 9.88 11 326114 262 50278737
Lymphadenopathy 10.91 9.88 151 325974 33348 50245651
Bifascicular block 10.89 9.88 8 326117 122 50278877
Atrial flutter 10.89 9.88 95 326030 8668 50270331
Binocular eye movement disorder 10.86 9.88 5 326120 29 50278970
Pneumocystis jirovecii pneumonia 10.85 9.88 53 326072 14610 50264389
Gouty arthritis 10.83 9.88 15 326110 505 50278494
Exercise tolerance increased 10.72 9.88 5 326120 30 50278969
Primary biliary cholangitis 10.71 9.88 23 326102 1109 50277890
Shock haemorrhagic 10.65 9.88 91 326034 8253 50270746
Maternal exposure timing unspecified 10.63 9.88 5 326120 3615 50275384
Post transplant lymphoproliferative disorder 10.62 9.88 7 326118 4197 50274802
Vaginal haemorrhage 10.59 9.88 104 326021 24447 50254552
Tenderness 10.58 9.88 73 326052 18492 50260507
Cardiogenic shock 10.56 9.88 150 325975 15449 50263550
Hyperthermia 10.55 9.88 21 326104 7675 50271324
Accelerated hypertension 10.51 9.88 13 326112 391 50278608
Inappropriate schedule of product discontinuation 10.50 9.88 4 326121 13 50278986
Renal artery stenosis 10.49 9.88 29 326096 1643 50277356
Nausea 10.42 9.88 4855 321270 700543 49578456
End stage renal disease 10.41 9.88 68 326057 5669 50273330
Aortic valve replacement 10.37 9.88 17 326108 666 50278333
Pneumonia aspiration 10.37 9.88 139 325986 30865 50248134
Malignant polyp 10.34 9.88 9 326116 177 50278822
Urinary straining 10.33 9.88 5 326120 33 50278966
Alanine aminotransferase 10.31 9.88 6 326119 60 50278939
Cholelithiasis 10.29 9.88 319 325806 37654 50241345
Unintended pregnancy 10.28 9.88 10 326115 4936 50274063
Alpha hydroxybutyrate dehydrogenase increased 10.28 9.88 4 326121 14 50278985
Cardiac valve disease 10.27 9.88 50 326075 3736 50275263
Noninfectious peritonitis 10.26 9.88 8 326117 134 50278865
Complication associated with device 10.26 9.88 54 326071 14601 50264398
Arrhythmia 10.25 9.88 283 325842 32849 50246150
Tendon rupture 10.24 9.88 80 326045 7064 50271935
Ocular icterus 10.24 9.88 47 326078 3428 50275571
Neuroleptic malignant syndrome 10.24 9.88 37 326088 11093 50267906
Collagen disorder 10.22 9.88 9 326116 180 50278819
Vitrectomy 10.21 9.88 8 326117 135 50278864
Bundle branch block left 10.20 9.88 72 326053 6158 50272841
Scleritis 10.20 9.88 4 326121 3223 50275776
Intracranial haematoma 10.18 9.88 12 326113 343 50278656
Aggression 10.17 9.88 87 326038 21029 50257970
Fungal infection 10.15 9.88 134 325991 29831 50249168
Haemorrhagic stroke 10.12 9.88 63 326062 5165 50273834
Drug ineffective for unapproved indication 10.10 9.88 88 326037 21193 50257806
Fructosamine increased 10.09 9.88 3 326122 3 50278996
Autoimmune encephalopathy 10.09 9.88 3 326122 3 50278996
Abdominal wall mass 10.09 9.88 3 326122 3 50278996
Juvenile idiopathic arthritis 10.09 9.88 3 326122 2876 50276123
Laryngotracheal oedema 10.08 9.88 5 326120 35 50278964
Renal cell carcinoma stage IV 10.07 9.88 4 326121 15 50278984
Atrial pressure increased 10.07 9.88 4 326121 15 50278984
Mitral valve stenosis 10.05 9.88 21 326104 993 50278006
Coeliac disease 10.04 9.88 26 326099 8659 50270340
Gastritis erosive 10.03 9.88 62 326063 5072 50273927
Blood glucose fluctuation 10.02 9.88 53 326072 4093 50274906
Heart sounds 10.00 9.88 16 326109 614 50278385
Gastric ulcer haemorrhage 9.95 9.88 56 326069 4428 50274571
Supraventricular extrasystoles 9.94 9.88 51 326074 3893 50275106
Stoma site haemorrhage 9.93 9.88 20 326105 921 50278078
Hepatic cyst 9.89 9.88 56 326069 4437 50274562
Type V hyperlipidaemia 9.89 9.88 13 326112 416 50278583

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1201.83 11.48 2555 319798 71464 29180710
Immune-mediated myositis 1124.82 11.48 479 321874 1124 29251050
Rhabdomyolysis 738.86 11.48 1874 320479 58934 29193240
Toxicity to various agents 497.74 11.48 701 321652 172960 29079214
Blood creatine phosphokinase increased 481.34 11.48 1241 321112 39403 29212771
Drug abuse 479.33 11.48 138 322215 79745 29172429
Off label use 403.30 11.48 1799 320554 299001 28953173
Febrile neutropenia 381.77 11.48 396 321957 111844 29140330
Myopathy 374.53 11.48 516 321837 10017 29242157
Myocardial infarction 330.20 11.48 2195 320158 108101 29144073
Foetal exposure during pregnancy 326.92 11.48 9 322344 33858 29218316
Necrotising myositis 325.14 11.48 140 322213 341 29251833
Drug ineffective 267.61 11.48 2602 319751 360568 28891606
Coronary artery disease 240.37 11.48 1037 321316 43153 29209021
Completed suicide 231.55 11.48 392 321961 89854 29162320
Neutropenia 230.80 11.48 704 321649 131007 29121167
Pyrexia 219.03 11.48 2043 320310 285579 28966595
Drug hypersensitivity 199.41 11.48 1353 321000 67053 29185121
Cerebrovascular accident 195.66 11.48 1472 320881 75439 29176735
Acute myocardial infarction 168.97 11.48 1003 321350 47435 29204739
Premature baby 161.72 11.48 6 322347 17274 29234900
Angina pectoris 157.92 11.48 662 321691 27188 29224986
Muscular weakness 144.67 11.48 1164 321189 60888 29191286
Dizziness 139.13 11.48 2868 319485 186816 29065358
Chest pain 134.80 11.48 1836 320517 110137 29142037
Low density lipoprotein increased 133.90 11.48 188 322165 3716 29248458
Acute kidney injury 126.99 11.48 3785 318568 261482 28990692
Drug resistance 125.83 11.48 39 322314 21501 29230673
Treatment failure 124.65 11.48 131 322222 36808 29215366
Coronary artery stenosis 124.09 11.48 283 322070 8290 29243884
Mucosal inflammation 123.31 11.48 98 322255 31497 29220677
Polymyositis 119.54 11.48 106 322247 1222 29250952
Malignant neoplasm progression 115.29 11.48 415 321938 73444 29178730
Bone marrow failure 115.06 11.48 79 322274 27370 29224804
Coronary artery occlusion 114.04 11.48 303 322050 9791 29242383
Muscle rupture 113.53 11.48 124 322229 1873 29250301
Product use in unapproved indication 109.03 11.48 531 321822 86344 29165830
Death 108.09 11.48 2872 319481 339212 28912962
Muscle spasms 107.64 11.48 1134 321219 63948 29188226
Cytomegalovirus infection 105.31 11.48 61 322292 23154 29229020
Transient ischaemic attack 99.98 11.48 510 321843 22760 29229414
Pancytopenia 96.08 11.48 523 321830 82645 29169529
White blood cell count decreased 95.87 11.48 525 321828 82837 29169337
Pneumonia 91.36 11.48 2726 319627 317446 28934728
High density lipoprotein decreased 91.28 11.48 136 322217 2843 29249331
Platelet count decreased 91.13 11.48 717 321636 103955 29148219
Leukopenia 89.60 11.48 305 322048 54898 29197276
Angina unstable 88.20 11.48 290 322063 10575 29241599
Sepsis 87.33 11.48 1065 321288 141617 29110557
Acute coronary syndrome 86.14 11.48 313 322040 12012 29240162
Ischaemic stroke 84.56 11.48 372 321981 15605 29236569
Thrombocytopenia 84.54 11.48 1001 321352 133822 29118352
Neutrophil count decreased 84.17 11.48 222 322131 43345 29208829
Graft versus host disease 81.79 11.48 6 322347 9622 29242552
Tendon rupture 81.54 11.48 199 322154 6096 29246078
Mitral valve incompetence 80.88 11.48 323 322030 12970 29239204
Dyspnoea 79.89 11.48 4337 318016 322395 28929779
Blood cholesterol increased 78.69 11.48 358 321995 15237 29236937
Drug dependence 78.25 11.48 68 322285 20913 29231261
Respiratory depression 78.06 11.48 25 322328 13498 29238676
Autoimmune myositis 76.37 11.48 31 322322 61 29252113
Atrial fibrillation 75.49 11.48 1592 320761 104054 29148120
Syncope 75.28 11.48 1276 321077 80095 29172079
Product monitoring error 74.34 11.48 116 322237 2529 29249645
Exposure during pregnancy 73.62 11.48 5 322348 8549 29243625
Erectile dysfunction 71.37 11.48 386 321967 17623 29234551
Stomatitis 70.26 11.48 191 322162 36922 29215252
Respiratory arrest 68.23 11.48 110 322243 25723 29226451
Low density lipoprotein decreased 68.09 11.48 69 322284 951 29251223
Overdose 67.94 11.48 550 321803 79269 29172905
Ascites 67.43 11.48 191 322162 36428 29215746
Blood triglycerides increased 67.29 11.48 298 322055 12536 29239638
Intentional self-injury 66.86 11.48 26 322327 12435 29239739
Pneumocystis jirovecii pneumonia 66.78 11.48 51 322302 16728 29235446
Muscle disorder 66.63 11.48 101 322252 2145 29250029
Infusion related reaction 64.92 11.48 252 322101 43634 29208540
Product use issue 64.75 11.48 314 322039 51130 29201044
Vascular stent thrombosis 64.54 11.48 108 322245 2502 29249672
Suicide attempt 64.23 11.48 176 322177 33934 29218240
Amnesia 63.60 11.48 444 321909 22199 29229975
Type 2 diabetes mellitus 63.55 11.48 305 322048 13276 29238898
Myositis 63.47 11.48 251 322102 10032 29242142
Muscle necrosis 61.97 11.48 59 322294 750 29251424
Intentional overdose 60.40 11.48 216 322137 38312 29213862
Poisoning 60.36 11.48 17 322336 9976 29242198
Myelosuppression 60.06 11.48 29 322324 12198 29239976
Disseminated intravascular coagulation 59.72 11.48 78 322275 19902 29232272
Low birth weight baby 59.50 11.48 3 322350 6605 29245569
Myopathy toxic 58.59 11.48 44 322309 393 29251781
Hypomagnesaemia 58.49 11.48 358 321995 17110 29235064
Bronchopulmonary aspergillosis 58.06 11.48 31 322322 12313 29239861
Multiple organ dysfunction syndrome 57.88 11.48 426 321927 62690 29189484
Asthenia 57.87 11.48 2884 319469 212366 29039808
Muscle atrophy 56.75 11.48 178 322175 6328 29245846
Disease progression 56.10 11.48 596 321757 81320 29170854
Respiratory failure 55.28 11.48 736 321617 96395 29155779
Pain in extremity 55.10 11.48 1585 320768 108848 29143326
Inferior vena cava dilatation 54.97 11.48 51 322302 626 29251548
Haemophagocytic lymphohistiocytosis 54.59 11.48 23 322330 10481 29241693
Dyspnoea exertional 54.40 11.48 623 321730 35867 29216307
Diabetic ketoacidosis 54.19 11.48 330 322023 15743 29236431
Aspergillus infection 53.67 11.48 24 322329 10557 29241617
Immune reconstitution inflammatory syndrome 53.64 11.48 10 322343 7792 29244382
Cardiac failure 53.14 11.48 1184 321169 78103 29174071
Serotonin syndrome 52.72 11.48 68 322285 17444 29234730
Pathogen resistance 52.50 11.48 12 322341 8104 29244070
Rectal haemorrhage 52.46 11.48 592 321761 33957 29218217
Haematuria 51.88 11.48 721 321632 43418 29208756
Drug interaction 51.66 11.48 2638 319715 194747 29057427
Fall 51.18 11.48 2391 319962 174787 29077387
Septic shock 50.99 11.48 436 321917 62124 29190050
Labelled drug-drug interaction medication error 49.80 11.48 263 322090 11896 29240278
Cytokine release syndrome 49.55 11.48 42 322311 13077 29239097
Intentional product misuse 49.37 11.48 202 322151 34459 29217715
Posterior reversible encephalopathy syndrome 49.37 11.48 18 322335 8958 29243216
Cardiac failure chronic 49.29 11.48 169 322184 6298 29245876
Presyncope 49.07 11.48 322 322031 15767 29236407
Infection 47.98 11.48 570 321783 76181 29175993
Chromaturia 47.79 11.48 270 322083 12532 29239642
Myocardial necrosis marker increased 47.38 11.48 70 322283 1452 29250722
Glycosylated haemoglobin increased 47.26 11.48 216 322137 9210 29242964
Cardiac disorder 46.80 11.48 616 321737 36647 29215527
Blood glucose increased 46.78 11.48 903 321450 58081 29194093
Psoriasis 46.60 11.48 547 321806 31680 29220494
Muscle injury 46.37 11.48 60 322293 1093 29251081
Bradycardia 46.18 11.48 987 321366 64642 29187532
Hypertensive emergency 45.95 11.48 51 322302 785 29251389
Intentional product use issue 45.93 11.48 273 322080 42225 29209949
C-reactive protein abnormal 45.75 11.48 8 322345 6528 29245646
Seizure 45.52 11.48 727 321626 92396 29159778
Oedema peripheral 45.14 11.48 1462 320891 102095 29150079
Upper gastrointestinal haemorrhage 44.62 11.48 399 321954 21515 29230659
Product prescribing error 44.47 11.48 342 322011 17634 29234540
Dermatomyositis 44.45 11.48 56 322297 992 29251182
Restlessness 43.40 11.48 112 322241 22033 29230141
Amyotrophic lateral sclerosis 43.30 11.48 51 322302 840 29251334
Ejection fraction decreased 42.94 11.48 310 322043 15668 29236506
Ventricular hypokinesia 42.71 11.48 128 322225 4437 29247737
Neurotoxicity 42.70 11.48 58 322295 14555 29237619
Epstein-Barr virus infection 42.48 11.48 10 322343 6619 29245555
Product substitution issue 42.20 11.48 205 322148 8967 29243207
Atrial septal defect 42.04 11.48 11 322342 6778 29245396
Acute myeloid leukaemia 42.04 11.48 72 322281 16441 29235733
Hyperkalaemia 41.82 11.48 919 321434 60473 29191701
Faeces discoloured 41.82 11.48 269 322084 13082 29239092
Ischaemic cardiomyopathy 41.80 11.48 146 322207 5492 29246682
Hepatic encephalopathy 40.93 11.48 49 322304 12986 29239188
Therapeutic product effect incomplete 40.64 11.48 256 322097 39049 29213125
Muscle enzyme increased 40.47 11.48 28 322325 217 29251957
Lactic acidosis 40.08 11.48 505 321848 29742 29222432
N-terminal prohormone brain natriuretic peptide increased 40.06 11.48 74 322279 1858 29250316
Agitation 39.84 11.48 362 321991 50942 29201232
Melaena 39.82 11.48 517 321836 30659 29221515
Arteriosclerosis 39.41 11.48 218 322135 10038 29242136
Haematotoxicity 39.35 11.48 12 322341 6687 29245487
Myocardial ischaemia 39.13 11.48 304 322049 15724 29236450
Low density lipoprotein abnormal 38.78 11.48 28 322325 234 29251940
Glomerular filtration rate decreased 38.42 11.48 232 322121 11034 29241140
Progressive multifocal leukoencephalopathy 38.01 11.48 24 322329 8695 29243479
Akathisia 37.97 11.48 13 322340 6729 29245445
Neuroleptic malignant syndrome 37.91 11.48 74 322279 16074 29236100
Post transplant lymphoproliferative disorder 37.85 11.48 7 322346 5486 29246688
Carotid artery stenosis 37.82 11.48 121 322232 4348 29247826
Coma 37.25 11.48 264 322089 39186 29212988
Exercise lack of 36.33 11.48 20 322333 97 29252077
Cystitis haemorrhagic 36.00 11.48 5 322348 4837 29247337
Cardiac failure congestive 35.95 11.48 1091 321262 75490 29176684
Hypoglycaemia 35.93 11.48 733 321620 47613 29204561
Arteriosclerosis coronary artery 35.91 11.48 218 322135 10387 29241787
Tumour lysis syndrome 35.84 11.48 60 322293 13824 29238350
Bacteraemia 35.61 11.48 78 322275 16245 29235929
Vomiting 35.24 11.48 1923 320430 210337 29041837
Heart rate irregular 34.96 11.48 254 322099 12863 29239311
Computerised tomogram coronary artery abnormal 34.90 11.48 24 322329 184 29251990
Pancreatitis acute 34.85 11.48 413 321940 23972 29228202
Cardio-respiratory arrest 34.69 11.48 368 321985 50233 29201941
Hepatitis cholestatic 34.59 11.48 158 322195 6735 29245439
Blood cholesterol decreased 34.53 11.48 47 322306 901 29251273
Condition aggravated 33.90 11.48 1278 321075 145017 29107157
Diabetic nephropathy 33.68 11.48 68 322285 1827 29250347
Neoplasm progression 33.58 11.48 98 322255 18514 29233660
Muscle fatigue 33.52 11.48 53 322300 1169 29251005
Nocturia 32.97 11.48 179 322174 8183 29243991
Drug withdrawal syndrome 32.95 11.48 94 322259 17890 29234284
Coronary artery bypass 32.75 11.48 119 322234 4566 29247608
Hepatocellular injury 32.69 11.48 365 321988 20878 29231296
Myelodysplastic syndrome 32.61 11.48 93 322260 17701 29234473
Drug ineffective for unapproved indication 31.78 11.48 67 322286 14147 29238027
Stent placement 31.49 11.48 111 322242 4195 29247979
Polymyalgia rheumatica 31.14 11.48 51 322302 1160 29251014
Genital swelling 30.65 11.48 20 322333 139 29252035
Troponin increased 30.61 11.48 188 322165 8995 29243179
Enterococcal infection 30.58 11.48 27 322326 8241 29243933
Substance abuse 30.54 11.48 18 322335 6769 29245405
Coronary artery restenosis 30.38 11.48 46 322307 976 29251198
Hypotension 30.25 11.48 2485 319868 191869 29060305
Lymphocyte count decreased 30.22 11.48 108 322245 19163 29233011
Vascular stent stenosis 30.11 11.48 46 322307 984 29251190
Haematoma 30.09 11.48 386 321967 22826 29229348
Orthostatic hypotension 30.06 11.48 378 321975 22251 29229923
Exercise tolerance decreased 30.03 11.48 108 322245 4123 29248051
Blood creatine phosphokinase MB increased 29.99 11.48 62 322291 1695 29250479
Blood cholesterol 29.92 11.48 21 322332 167 29252007
Depressed level of consciousness 29.85 11.48 258 322095 36684 29215490
Febrile bone marrow aplasia 29.69 11.48 22 322331 7329 29244845
Maternal exposure during pregnancy 28.96 11.48 5 322348 4118 29248056
Toxic epidermal necrolysis 28.96 11.48 101 322252 18052 29234122
Cerebral haemorrhage 28.73 11.48 492 321861 30934 29221240
Tricuspid valve incompetence 28.71 11.48 173 322180 8221 29243953
Aggression 28.37 11.48 249 322104 35292 29216882
Psychotic disorder 28.13 11.48 120 322233 20234 29231940
Cytomegalovirus viraemia 28.10 11.48 17 322336 6303 29245871
Intermittent claudication 27.94 11.48 66 322287 1979 29250195
Palpitations 27.86 11.48 505 321848 32099 29220075
Mixed liver injury 27.81 11.48 66 322287 1985 29250189
Therapy partial responder 27.64 11.48 11 322342 5188 29246986
Haematochezia 27.57 11.48 561 321792 36422 29215752
Hepatitis C 27.44 11.48 34 322319 8876 29243298
Diabetes mellitus inadequate control 27.36 11.48 226 322127 11908 29240266
Liver function test abnormal 27.26 11.48 455 321898 28463 29223711
Glycogen storage disease type V 27.12 11.48 12 322341 32 29252142
Tachycardia 27.06 11.48 592 321761 71818 29180356
Stenosis 26.98 11.48 44 322309 997 29251177
Drug use disorder 26.74 11.48 3 322350 3419 29248755
Carotid artery occlusion 26.71 11.48 64 322289 1937 29250237
Hepatic enzyme increased 26.63 11.48 517 321836 33282 29218892
Transplant rejection 26.48 11.48 37 322316 9175 29242999
Blood loss anaemia 26.30 11.48 152 322201 7114 29245060
Gastrointestinal haemorrhage 26.14 11.48 1088 321265 78445 29173729
Type V hyperlipidaemia 26.06 11.48 35 322318 662 29251512
Acute respiratory distress syndrome 26.03 11.48 145 322208 22790 29229384
Tendonitis 25.92 11.48 162 322191 7799 29244375
Status epilepticus 25.74 11.48 49 322304 10745 29241429
Haemorrhagic stroke 25.60 11.48 129 322224 5727 29246447
Blood cholesterol abnormal 25.54 11.48 52 322301 1406 29250768
Blood urea abnormal 25.43 11.48 36 322317 717 29251457
Respiratory distress 25.15 11.48 226 322127 31880 29220294
Cytopenia 25.08 11.48 43 322310 9816 29242358
Ventricular enlargement 24.98 11.48 28 322325 436 29251738
Hepatitis B reactivation 24.81 11.48 3 322350 3226 29248948
Abnormal behaviour 24.75 11.48 149 322204 22978 29229196
Pruritus genital 24.75 11.48 30 322323 510 29251664
Carotid artery disease 24.70 11.48 38 322315 818 29251356
Degenerative mitral valve disease 24.50 11.48 20 322333 204 29251970
Cardiac failure acute 24.50 11.48 178 322175 9014 29243160
Pseudomonas infection 24.39 11.48 51 322302 10801 29241373
Ocular myasthenia 24.35 11.48 20 322333 206 29251968
Eye injury 24.32 11.48 32 322321 593 29251581
Swollen tongue 24.29 11.48 222 322131 12044 29240130
Encephalopathy 24.11 11.48 219 322134 30824 29221350
Hyperlipidaemia 23.99 11.48 226 322127 12364 29239810
Normocytic anaemia 23.73 11.48 61 322292 1931 29250243
Hepatocellular carcinoma 23.69 11.48 25 322328 7013 29245161
Hypoalbuminaemia 23.52 11.48 48 322305 10257 29241917
Foetal growth restriction 23.51 11.48 6 322347 3760 29248414
Balance disorder 23.23 11.48 537 321816 35633 29216541
Colitis 23.17 11.48 223 322130 31025 29221149
Cardiac aneurysm 23.03 11.48 36 322317 786 29251388
Hyperammonaemia 22.81 11.48 17 322336 5646 29246528
Candida infection 22.78 11.48 87 322266 15138 29237036
Product odour abnormal 22.77 11.48 32 322321 633 29251541
Sedation 22.61 11.48 105 322248 17300 29234874
Dystonia 22.60 11.48 45 322308 9704 29242470
Appendicitis 22.60 11.48 38 322315 8741 29243433
Muscle discomfort 22.49 11.48 12 322341 54 29252120
Drug level increased 22.30 11.48 117 322236 18670 29233504
Nephropathy toxic 22.17 11.48 53 322300 10703 29241471
Abnormal weight gain 21.72 11.48 37 322316 870 29251304
Oropharyngeal pain 21.71 11.48 209 322144 29076 29223098
Peripheral vascular disorder 21.68 11.48 103 322250 4464 29247710
Diabetes mellitus 21.60 11.48 578 321775 39253 29212921
Acquired claw toe 21.46 11.48 9 322344 20 29252154
Ventricular septal defect 21.32 11.48 6 322347 3523 29248651
Pelvic mass 21.26 11.48 18 322335 194 29251980
Miosis 21.24 11.48 34 322319 7975 29244199
Sinusitis 21.11 11.48 256 322097 34094 29218080
Apparent death 21.09 11.48 6 322347 3498 29248676
Ventricular dyskinesia 21.04 11.48 18 322335 197 29251977
Altered state of consciousness 20.83 11.48 129 322224 19760 29232414
Cardiotoxicity 20.76 11.48 13 322340 4731 29247443
Klebsiella infection 20.64 11.48 30 322323 7319 29244855
Accidental exposure to product 20.60 11.48 55 322298 10698 29241476
Arterial stenosis 20.55 11.48 41 322312 1092 29251082
Device related infection 20.51 11.48 94 322259 15542 29236632
Chest discomfort 20.47 11.48 651 321702 45332 29206842
Arterial occlusive disease 20.36 11.48 91 322262 3843 29248331
Musculoskeletal pain 20.21 11.48 435 321918 28518 29223656
Pulmonary vascular disorder 20.11 11.48 28 322325 549 29251625
Idiopathic pulmonary fibrosis 20.09 11.48 78 322275 3090 29249084
Paradoxical drug reaction 19.98 11.48 3 322350 2738 29249436
Obstructive pancreatitis 19.89 11.48 24 322329 406 29251768
Lymph node calcification 19.88 11.48 15 322338 135 29252039
Pneumatosis intestinalis 19.88 11.48 5 322348 3164 29249010
Hypertransaminasaemia 19.87 11.48 85 322268 3521 29248653
Ileus 19.84 11.48 85 322268 14317 29237857
Shock 19.83 11.48 144 322209 21260 29230914
Hypercholesterolaemia 19.77 11.48 141 322212 7097 29245077
Potassium wasting nephropathy 19.74 11.48 13 322340 92 29252082
Myoglobin blood increased 19.68 11.48 57 322296 1938 29250236
Pulmonary haemorrhage 19.65 11.48 45 322308 9225 29242949
Quadriparesis 19.63 11.48 42 322311 1177 29250997
Radiculitis brachial 19.63 11.48 8 322345 16 29252158
Oxygen saturation decreased 19.61 11.48 358 321995 44579 29207595
Blood immunoglobulin E increased 19.56 11.48 56 322297 1891 29250283
Essential hypertension 19.48 11.48 65 322288 2388 29249786
Memory impairment 19.42 11.48 528 321825 35942 29216232
Pneumonia cytomegaloviral 19.40 11.48 3 322350 2679 29249495
Fungal infection 19.33 11.48 80 322273 13605 29238569
Cerebral infarction 19.29 11.48 377 321976 24298 29227876
Muscle strain 19.25 11.48 83 322270 3450 29248724
Atrial enlargement 19.24 11.48 21 322332 317 29251857
Penile haemorrhage 19.12 11.48 28 322325 576 29251598
Nicotine dependence 19.05 11.48 25 322328 462 29251712
Shock haemorrhagic 18.98 11.48 173 322180 9378 29242796
Pneumonia fungal 18.91 11.48 21 322332 5756 29246418
Hepatitis acute 18.90 11.48 128 322225 6334 29245840
Nocardiosis 18.86 11.48 6 322347 3254 29248920
Aldolase increased 18.83 11.48 11 322342 61 29252113
Brain oedema 18.82 11.48 69 322284 12151 29240023
Cardiac valve disease 18.79 11.48 71 322282 2777 29249397
Abdominal pain 18.74 11.48 1247 321106 134110 29118064
Dermatitis atopic 18.70 11.48 60 322293 2159 29250015
Iliac artery stenosis 18.69 11.48 11 322342 62 29252112
Dyspnoea at rest 18.68 11.48 77 322276 3137 29249037
Catatonia 18.53 11.48 13 322340 4455 29247719
Somnolence 18.49 11.48 836 321517 93119 29159055
Disease recurrence 18.39 11.48 100 322253 15814 29236360
Ageusia 18.33 11.48 163 322190 8775 29243399
C-reactive protein increased 18.27 11.48 356 321997 43907 29208267
Herbal interaction 18.21 11.48 20 322333 304 29251870
Enthesopathy 18.20 11.48 9 322344 3734 29248440
Penis injury 18.17 11.48 18 322335 241 29251933
Pruritus 18.13 11.48 1494 320859 115355 29136819
Venoocclusive disease 18.01 11.48 3 322350 2536 29249638
Hypocalcaemia 17.98 11.48 321 322032 20344 29231830
Hepatitis B 17.97 11.48 20 322333 5477 29246697
Lipids abnormal 17.97 11.48 19 322334 276 29251898
Electrocardiogram abnormal 17.94 11.48 139 322214 7183 29244991
Osteonecrosis of jaw 17.86 11.48 106 322247 16404 29235770
Post micturition dribble 17.85 11.48 7 322346 12 29252162
Clostridium difficile infection 17.80 11.48 103 322250 16038 29236136
Transient global amnesia 17.76 11.48 20 322333 313 29251861
Hyperbilirubinaemia 17.72 11.48 93 322260 14841 29237333
Thrombotic microangiopathy 17.71 11.48 43 322310 8638 29243536
Gastrointestinal angiodysplasia 17.68 11.48 26 322327 537 29251637
Pericardial haemorrhage 17.65 11.48 71 322282 2860 29249314
Withdrawal syndrome 17.64 11.48 61 322292 10931 29241243
Neutropenic sepsis 17.55 11.48 67 322286 11660 29240514
Hepatic failure 17.46 11.48 240 322113 31272 29220902
Epicondylitis 17.32 11.48 21 322332 357 29251817
Lymphadenopathy 17.23 11.48 182 322171 24867 29227307
Vascular graft 17.21 11.48 43 322310 1337 29250837
Aplastic anaemia 17.12 11.48 35 322318 7475 29244699
Left atrial enlargement 17.09 11.48 30 322323 723 29251451
Occupational problem environmental 17.09 11.48 6 322347 6 29252168
Avoidant personality disorder 17.09 11.48 6 322347 6 29252168
Product administered to patient of inappropriate age 17.02 11.48 4 322349 2651 29249523
Cytomegalovirus test positive 16.99 11.48 8 322345 3415 29248759
Skin toxicity 16.97 11.48 10 322343 3761 29248413
Palmar-plantar erythrodysaesthesia syndrome 16.91 11.48 93 322260 14666 29237508
Herpes simplex 16.88 11.48 17 322336 4873 29247301
Neuromyopathy 16.87 11.48 33 322320 866 29251308
Therapeutic product effect decreased 16.79 11.48 223 322130 29228 29222946
Neutropenic colitis 16.77 11.48 3 322350 2408 29249766
Hypogammaglobulinaemia 16.70 11.48 24 322329 5883 29246291
Dyskinesia 16.70 11.48 139 322214 19922 29232252
Fibrous histiocytoma 16.65 11.48 12 322341 100 29252074
Blood triglycerides decreased 16.63 11.48 10 322343 59 29252115
Epilepsy 16.60 11.48 125 322228 18307 29233867
Vitreous detachment 16.58 11.48 30 322323 741 29251433
Weight decreased 16.56 11.48 1883 320470 149022 29103152
Pulmonary valve incompetence 16.55 11.48 29 322324 698 29251476
Hepatic cytolysis 16.49 11.48 151 322202 8196 29243978
Cytomegalovirus infection reactivation 16.49 11.48 8 322345 3356 29248818
Diffuse large B-cell lymphoma recurrent 16.48 11.48 4 322349 2593 29249581
Autoimmune disorder 16.48 11.48 45 322308 1478 29250696
Clonus 16.45 11.48 3 322350 2375 29249799
Myasthenia gravis 16.39 11.48 73 322280 3078 29249096
Left atrial dilatation 16.34 11.48 48 322305 1645 29250529
Bacterial infection 16.30 11.48 79 322274 12869 29239305
Systemic candida 16.29 11.48 5 322348 2775 29249399
Pollakiuria 16.25 11.48 267 322086 16649 29235525
Cholestasis 16.21 11.48 352 322001 23110 29229064
Therapy non-responder 16.21 11.48 238 322115 30673 29221501
Peripheral paralysis 16.10 11.48 8 322345 30 29252144
Flatulence 16.09 11.48 277 322076 17432 29234742
Drug abuser 16.05 11.48 11 322342 3816 29248358
Product contamination physical 16.00 11.48 7 322346 18 29252156
Suicidal ideation 15.96 11.48 274 322079 34442 29217732
Dyspnoea paroxysmal nocturnal 15.90 11.48 42 322311 1352 29250822
Anticoagulation drug level increased 15.78 11.48 23 322330 471 29251703
Aortic aneurysm 15.75 11.48 119 322234 6101 29246073
Mastitis 15.75 11.48 14 322339 162 29252012
Psychomotor hyperactivity 15.74 11.48 42 322311 8171 29244003
Staphylococcal infection 15.73 11.48 224 322129 29016 29223158
Haemorrhage intracranial 15.67 11.48 234 322119 14308 29237866
Aortic valve replacement 15.58 11.48 28 322325 688 29251486
Gout 15.54 11.48 265 322088 16646 29235528
Atrial flutter 15.53 11.48 225 322128 13669 29238505
Lip swelling 15.51 11.48 205 322148 12205 29239969
Urine flow decreased 15.49 11.48 36 322317 1068 29251106
Loss of personal independence in daily activities 15.47 11.48 190 322163 25250 29226924
Haematoma muscle 15.44 11.48 33 322320 924 29251250
Vertigo 15.43 11.48 329 322024 21532 29230642
Bilirubin conjugated abnormal 15.32 11.48 11 322342 91 29252083
Herpes zoster 15.21 11.48 233 322120 29819 29222355
Anal abscess 15.18 11.48 21 322332 5230 29246944
Synovitis 15.17 11.48 64 322289 10826 29241348
Blood creatine increased 15.16 11.48 89 322264 4189 29247985
Thrombocytopenic purpura 15.15 11.48 34 322319 985 29251189
Autoimmune myocarditis 15.15 11.48 14 322339 171 29252003
Mydriasis 15.06 11.48 27 322326 6058 29246116
Alcohol abuse 15.03 11.48 15 322338 4318 29247856
Escherichia infection 15.02 11.48 32 322321 6732 29245442
Hepatojugular reflux 14.90 11.48 22 322331 456 29251718
Right ventricular enlargement 14.89 11.48 14 322339 175 29251999
Wound haematoma 14.85 11.48 9 322344 54 29252120
Hypercalcaemia 14.84 11.48 80 322273 12679 29239495
Central obesity 14.83 11.48 22 322331 458 29251716
Peripheral ischaemia 14.74 11.48 101 322252 5018 29247156
Blood pressure fluctuation 14.74 11.48 142 322211 19752 29232422
Pneumonia aspiration 14.70 11.48 297 322056 36440 29215734
Pneumonitis 14.68 11.48 216 322137 27828 29224346
Scrotal pain 14.67 11.48 29 322324 767 29251407
Dysmorphism 14.66 11.48 7 322346 2964 29249210
Oscillopsia 14.66 11.48 8 322345 38 29252136
Eructation 14.63 11.48 84 322269 3922 29248252
Peripheral artery stenosis 14.59 11.48 30 322323 817 29251357
Haemorrhagic transformation stroke 14.54 11.48 39 322314 1267 29250907
Peripheral arterial occlusive disease 14.52 11.48 100 322253 4976 29247198
Hyponatraemic syndrome 14.52 11.48 14 322339 181 29251993
Osteonecrosis 14.52 11.48 87 322266 13432 29238742
Heart valve incompetence 14.50 11.48 37 322316 1166 29251008
Therapeutic response decreased 14.49 11.48 186 322167 24525 29227649
Toe amputation 14.44 11.48 54 322299 2101 29250073
Cardiomyopathy 14.43 11.48 234 322119 14553 29237621
Orthopnoea 14.35 11.48 92 322261 4468 29247706
Deep vein thrombosis 14.26 11.48 497 321856 56902 29195272
Hepatic vein dilatation 14.23 11.48 15 322338 217 29251957
Angiocardiogram 14.22 11.48 14 322339 186 29251988
Lipodystrophy acquired 14.22 11.48 8 322345 3086 29249088
Lipids increased 14.15 11.48 29 322324 788 29251386
Arterial repair 14.12 11.48 4 322349 0 29252174
Cells in urine 14.12 11.48 4 322349 0 29252174
Blood glucose decreased 14.11 11.48 197 322156 11872 29240302
Hypernatraemia 13.98 11.48 38 322315 7348 29244826
Lacunar stroke 13.98 11.48 12 322341 132 29252042
Blood creatine phosphokinase abnormal 13.93 11.48 14 322339 191 29251983
Impatience 13.89 11.48 17 322336 292 29251882
Discoloured vomit 13.89 11.48 21 322332 445 29251729
Adrenal insufficiency 13.88 11.48 68 322285 11046 29241128
Cardiac stress test abnormal 13.86 11.48 18 322335 329 29251845
AST/ALT ratio abnormal 13.83 11.48 6 322347 15 29252159
Rhinovirus infection 13.82 11.48 9 322344 3207 29248967
Musculoskeletal stiffness 13.77 11.48 307 322046 37151 29215023
Rheumatoid arthritis 13.76 11.48 257 322096 31895 29220279
Congenital diaphragmatic anomaly 13.75 11.48 7 322346 28 29252146
Hypertension 13.73 11.48 1462 320891 115152 29137022
Accidental overdose 13.71 11.48 124 322229 17469 29234705
Microcytic anaemia 13.70 11.48 51 322302 1980 29250194
Transplant failure 13.69 11.48 7 322346 2849 29249325
Peripheral artery occlusion 13.68 11.48 41 322312 1421 29250753
Staphylococcal sepsis 13.67 11.48 50 322303 8812 29243362
Mouth swelling 13.64 11.48 43 322310 1533 29250641
Urticaria chronic 13.62 11.48 10 322343 86 29252088
Lipoprotein (a) increased 13.60 11.48 8 322345 45 29252129
Sopor 13.60 11.48 67 322286 10867 29241307
Nausea 13.59 11.48 2866 319487 286389 28965785
Hemianaesthesia 13.53 11.48 10 322343 87 29252087
Pseudohyponatraemia 13.52 11.48 9 322344 65 29252109
Cardiovascular disorder 13.51 11.48 153 322200 8782 29243392
Drug level decreased 13.50 11.48 30 322323 6217 29245957
Ataxia 13.47 11.48 77 322276 12026 29240148
Calculus urinary 13.46 11.48 35 322318 1116 29251058
Blood electrolytes abnormal 13.41 11.48 30 322323 867 29251307
Ventricular hypertrophy 13.40 11.48 86 322267 4178 29247996
Drug screen positive 13.36 11.48 13 322340 3788 29248386
Infective exacerbation of chronic obstructive airways disease 13.35 11.48 44 322309 1606 29250568
Atrioventricular block second degree 13.30 11.48 69 322284 3099 29249075
Encephalitis toxic 13.24 11.48 16 322337 271 29251903
Generalised tonic-clonic seizure 13.18 11.48 139 322214 19000 29233174
Non-cardiac chest pain 13.18 11.48 81 322272 3876 29248298
Clostridium difficile colitis 13.17 11.48 87 322266 13125 29239049
Brain stem haematoma 13.11 11.48 11 322342 117 29252057
Liver palpable 13.11 11.48 16 322337 274 29251900
Spinal stenosis 13.11 11.48 87 322266 4276 29247898
Second primary malignancy 13.07 11.48 34 322319 6671 29245503
Inclusion body myositis 13.06 11.48 6 322347 18 29252156
Large intestine polyp 12.98 11.48 118 322235 6391 29245783
Electrocardiogram ST-T change 12.98 11.48 22 322331 515 29251659
Mitochondrial toxicity 12.98 11.48 5 322348 2406 29249768
Splenomegaly 12.96 11.48 88 322265 13191 29238983
Facial asymmetry 12.89 11.48 16 322337 279 29251895
Implantable defibrillator insertion 12.83 11.48 25 322328 654 29251520
Hepatosplenomegaly 12.74 11.48 13 322340 3704 29248470
Chronic obstructive pulmonary disease 12.71 11.48 557 321796 40398 29211776
Intraventricular haemorrhage 12.69 11.48 64 322289 2842 29249332
Normal tension glaucoma 12.60 11.48 6 322347 20 29252154
Peripheral swelling 12.60 11.48 831 321522 62908 29189266
Carcinoid tumour of the gastrointestinal tract 12.57 11.48 8 322345 53 29252121
Macroglossia 12.55 11.48 18 322335 363 29251811
Gait disturbance 12.54 11.48 945 321408 72404 29179770
Metastases to central nervous system 12.54 11.48 38 322315 7093 29245081
Hepatic cirrhosis 12.52 11.48 99 322254 14345 29237829
Abnormal loss of weight 12.49 11.48 75 322278 3559 29248615
Nipple pain 12.49 11.48 23 322330 576 29251598
Coronary artery surgery 12.49 11.48 10 322343 99 29252075
Injection site pain 12.48 11.48 264 322089 32182 29219992
BK virus infection 12.47 11.48 20 322333 4687 29247487
Spur cell anaemia 12.45 11.48 8 322345 54 29252120
Electrocardiogram ST segment depression 12.42 11.48 52 322301 2133 29250041
Lymphoproliferative disorder 12.40 11.48 6 322347 2521 29249653
Adenocarcinoma gastric 12.34 11.48 33 322320 1070 29251104
Pleural effusion 12.34 11.48 649 321704 71259 29180915
Conjunctival hyperaemia 12.32 11.48 4 322349 2141 29250033
Hypoxia 12.29 11.48 408 321945 46971 29205203
Smooth muscle antibody positive 12.27 11.48 5 322348 10 29252164
Primary biliary cholangitis 12.25 11.48 11 322342 129 29252045
Lacunar infarction 12.25 11.48 62 322291 2757 29249417
Food interaction 12.24 11.48 29 322324 871 29251303
Vascular graft occlusion 12.23 11.48 22 322331 541 29251633
Angioedema 12.22 11.48 444 321909 31471 29220703
Carotid endarterectomy 12.21 11.48 8 322345 56 29252118
Peritonitis 12.21 11.48 103 322250 14721 29237453
Tuberculosis 12.19 11.48 39 322314 7157 29245017
Ventricular arrhythmia 12.18 11.48 89 322264 4515 29247659
Hypoaesthesia eye 12.18 11.48 6 322347 22 29252152
Portal hypertension 12.17 11.48 12 322341 3474 29248700
International normalised ratio increased 12.16 11.48 596 321757 43776 29208398
Gait inability 12.16 11.48 274 322079 18101 29234073
Liver transplant 12.15 11.48 5 322348 2311 29249863
Congestive cardiomyopathy 12.13 11.48 118 322235 6512 29245662
Rheumatoid nodule 12.11 11.48 4 322349 2118 29250056
Lipid metabolism disorder 12.10 11.48 16 322337 298 29251876
Intestinal obstruction 12.09 11.48 143 322210 19134 29233040
Oesophageal pain 12.07 11.48 26 322327 732 29251442
Neurodermatitis 12.05 11.48 14 322339 227 29251947
Small intestinal obstruction 12.04 11.48 88 322265 12973 29239201
Abscess 12.03 11.48 60 322293 9702 29242472
Delirium 12.01 11.48 332 322021 39065 29213109
Speech disorder developmental 11.98 11.48 3 322350 1904 29250270
Sinonasal obstruction 11.98 11.48 6 322347 23 29252151
Subdural haematoma 11.95 11.48 271 322082 17922 29234252
Streptococcal infection 11.95 11.48 19 322334 4469 29247705
Erythema 11.94 11.48 688 321665 74918 29177256
Injection site erythema 11.93 11.48 96 322257 13860 29238314
Paraesthesia 11.93 11.48 709 321644 53136 29199038
Chronic kidney disease 11.91 11.48 498 321855 35918 29216256
Peripheral coldness 11.91 11.48 112 322241 6124 29246050
Left ventricular dilatation 11.86 11.48 24 322329 646 29251528
Glycosylated haemoglobin abnormal 11.80 11.48 10 322343 108 29252066
Primary hypoparathyroidism 11.79 11.48 6 322347 24 29252150
Ammonia increased 11.78 11.48 16 322337 4015 29248159
Pyonephrosis 11.77 11.48 8 322345 60 29252114
Skin discomfort 11.77 11.48 8 322345 60 29252114
Pneumothorax 11.77 11.48 113 322240 15729 29236445
Bundle branch block left 11.74 11.48 98 322255 5179 29246995
Periodontitis 11.74 11.48 45 322308 1772 29250402
Infarction 11.72 11.48 55 322298 2371 29249803
Mitral valve calcification 11.71 11.48 21 322332 515 29251659
Lower gastrointestinal haemorrhage 11.69 11.48 139 322214 8074 29244100
Heart valve stenosis 11.66 11.48 5 322348 12 29252162
Gynaecomastia 11.66 11.48 139 322214 8078 29244096
Nightmare 11.64 11.48 182 322171 11235 29240939
Decreased gait velocity 11.60 11.48 11 322342 139 29252035
Atrioventricular block complete 11.58 11.48 136 322217 7875 29244299
Upper respiratory tract infection 11.58 11.48 219 322134 27130 29225044
Inflammation 11.57 11.48 176 322177 22552 29229622
Human herpesvirus 6 infection 11.57 11.48 3 322350 1860 29250314
Mean cell volume abnormal 11.56 11.48 15 322338 274 29251900
Staphylococcal bacteraemia 11.55 11.48 39 322314 7040 29245134
Urinary retention 11.55 11.48 441 321912 31457 29220717
Euglycaemic diabetic ketoacidosis 11.54 11.48 58 322295 2572 29249602
Autoimmune hepatitis 11.54 11.48 73 322280 3529 29248645

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Immune-mediated myositis 1856.40 10.35 737 541943 1941 63954111
Myalgia 1623.96 10.35 3901 538779 154716 63801336
Rhabdomyolysis 1510.83 10.35 2743 539937 88983 63867069
Drug ineffective 816.58 10.35 3972 538708 836275 63119777
Blood creatine phosphokinase increased 697.38 10.35 1530 541150 57028 63899024
Myocardial infarction 690.48 10.35 2995 539685 162826 63793226
Myopathy 688.27 10.35 796 541884 16884 63939168
Maternal exposure during pregnancy 653.19 10.35 38 542642 95846 63860206
Acute kidney injury 633.63 10.35 6160 536520 443080 63512972
Toxicity to various agents 611.28 10.35 1345 541335 362168 63593884
Off label use 611.21 10.35 2995 539685 629811 63326241
Cerebrovascular accident 567.99 10.35 2479 540201 135104 63820948
Necrotising myositis 553.98 10.35 227 542453 667 63955385
Completed suicide 552.88 10.35 644 542036 223770 63732282
Drug abuse 479.11 10.35 258 542422 132116 63823936
Coronary artery disease 475.38 10.35 1348 541332 59085 63896967
Exposure during pregnancy 470.26 10.35 52 542628 77623 63878429
Acute myocardial infarction 445.89 10.35 1446 541234 68272 63887780
Hand deformity 421.09 10.35 27 542653 62744 63893308
Treatment failure 407.85 10.35 238 542442 116578 63839474
Synovitis 400.23 10.35 166 542514 98924 63857128
Pemphigus 384.81 10.35 34 542646 60667 63895385
Febrile neutropenia 382.08 10.35 618 542062 187039 63769013
Infusion related reaction 353.57 10.35 522 542158 163945 63792107
Muscular weakness 332.54 10.35 2019 540661 125319 63830733
Drug hypersensitivity 327.79 10.35 3248 539432 234567 63721485
Contraindicated product administered 314.04 10.35 267 542413 107562 63848490
Systemic lupus erythematosus 307.04 10.35 134 542546 77478 63878574
Glossodynia 298.00 10.35 87 542593 64609 63891443
Therapeutic product effect decreased 295.88 10.35 320 542360 115031 63841021
Angina pectoris 280.96 10.35 927 541753 44154 63911898
Drug interaction 280.68 10.35 4440 538240 357643 63598409
Pericarditis 261.82 10.35 99 542581 62417 63893635
Rheumatoid factor positive 257.21 10.35 8 542672 34930 63921122
Arthropathy 250.23 10.35 394 542286 120573 63835479
Polymyositis 246.33 10.35 195 542485 2515 63953537
Chest pain 244.11 10.35 3046 539634 232934 63723118
Drug intolerance 240.40 10.35 795 541885 187197 63768855
Neutropenia 232.06 10.35 1131 541549 238493 63717559
Hypomagnesaemia 219.14 10.35 753 541927 36623 63919429
Pyrexia 215.43 10.35 3356 539324 555288 63400764
Hyperkalaemia 212.61 10.35 1519 541161 99610 63856442
Rheumatoid arthritis 211.95 10.35 692 541988 163602 63792450
Coronary artery stenosis 206.39 10.35 353 542327 10895 63945157
Product use issue 205.56 10.35 625 542055 151090 63804962
Stomatitis 204.68 10.35 381 542299 109224 63846828
Joint swelling 201.96 10.35 1028 541652 214354 63741698
Transient ischaemic attack 196.69 10.35 815 541865 43367 63912685
Angina unstable 195.33 10.35 414 542266 15053 63940999
Duodenal ulcer perforation 193.19 10.35 30 542650 34595 63921457
Atrial fibrillation 192.79 10.35 2245 540435 168844 63787208
Coronary artery occlusion 183.80 10.35 379 542301 13512 63942540
Alopecia 183.28 10.35 744 541936 164946 63791106
Ischaemic stroke 182.65 10.35 599 542081 28436 63927616
Sinusitis 175.76 10.35 633 542047 145295 63810757
Muscle spasms 175.46 10.35 1887 540793 139136 63816916
Syncope 174.72 10.35 2062 540618 155573 63800479
Infection 174.10 10.35 881 541799 183999 63772053
Helicobacter infection 172.29 10.35 54 542626 38308 63917744
Acute coronary syndrome 170.98 10.35 450 542230 18860 63937192
Wound 170.90 10.35 236 542444 76241 63879811
Hypoglycaemia 166.20 10.35 1310 541370 88582 63867470
Lactic acidosis 164.84 10.35 981 541699 60429 63895623
Hypersensitivity 160.00 10.35 982 541698 195470 63760582
Product use in unapproved indication 155.48 10.35 861 541819 175757 63780295
Dizziness 154.52 10.35 4723 537957 425440 63530612
Fall 153.05 10.35 4589 538091 412237 63543815
Diabetic ketoacidosis 150.93 10.35 573 542107 29272 63926780
Blood glucose increased 148.48 10.35 1367 541313 96706 63859346
Sleep disorder due to general medical condition, insomnia type 148.31 10.35 22 542658 26248 63929804
Pain 147.09 10.35 3541 539139 549970 63406082
Asthenia 143.27 10.35 4660 538020 423384 63532668
Bradycardia 142.93 10.35 1573 541107 116646 63839406
Hypertensive emergency 141.99 10.35 132 542548 2144 63953908
Drug resistance 141.37 10.35 59 542621 35043 63921009
Gastrointestinal haemorrhage 139.26 10.35 1714 540966 130598 63825454
Rectal haemorrhage 138.38 10.35 943 541737 60874 63895178
Melaena 136.46 10.35 844 541836 52704 63903348
Swelling 134.04 10.35 794 541886 159424 63796628
Myositis 133.31 10.35 370 542310 16007 63940045
Discomfort 130.06 10.35 306 542374 80572 63875480
Cytomegalovirus infection 129.47 10.35 76 542604 37123 63918929
Low density lipoprotein increased 129.17 10.35 233 542447 7507 63948545
Folliculitis 128.67 10.35 46 542634 30031 63926021
Intentional overdose 126.50 10.35 364 542316 89580 63866472
Pregnancy 126.17 10.35 14 542666 20851 63935201
Cardiac failure congestive 125.31 10.35 1663 541017 128917 63827135
Irritable bowel syndrome 124.97 10.35 80 542600 37289 63918763
Cardiac failure 122.98 10.35 1676 541004 130697 63825355
Device expulsion 120.95 10.35 17 542663 21119 63934933
Cholestasis 119.24 10.35 715 541965 44157 63911895
Mucosal inflammation 119.07 10.35 215 542465 62369 63893683
Myocardial ischaemia 118.89 10.35 448 542232 22803 63933249
Autoimmune myositis 118.14 10.35 48 542632 137 63955915
Malignant neoplasm progression 117.86 10.35 518 542162 112353 63843699
Mitral valve incompetence 117.53 10.35 476 542204 25062 63930990
Impaired healing 115.73 10.35 207 542473 60266 63895786
Labelled drug-drug interaction medication error 115.23 10.35 428 542252 21634 63934418
Dyspnoea 115.12 10.35 7257 535423 711417 63244635
Intentional self-injury 115.07 10.35 50 542630 28994 63927058
Cerebral haemorrhage 114.72 10.35 780 541900 50310 63905742
Product monitoring error 113.29 10.35 181 542499 5273 63950779
Liver function test abnormal 111.61 10.35 869 541811 58532 63897520
Glycosylated haemoglobin increased 111.28 10.35 342 542338 15677 63940375
Haematuria 108.33 10.35 875 541805 59596 63896456
Bone marrow failure 107.10 10.35 148 542532 47804 63908248
Condition aggravated 107.03 10.35 2353 540327 370073 63585979
Respiratory depression 105.27 10.35 33 542647 23410 63932642
Premature delivery 103.95 10.35 16 542664 18573 63937479
Hepatitis cholestatic 103.30 10.35 279 542401 11876 63944176
Hepatocellular injury 102.99 10.35 693 541987 44542 63911510
Abdominal discomfort 102.57 10.35 1009 541671 181313 63774739
Haematochezia 101.37 10.35 927 541753 65446 63890606
Intentional product use issue 101.18 10.35 435 542245 94929 63861123
Abortion spontaneous 98.48 10.35 44 542636 25099 63930953
Pancytopenia 97.97 10.35 754 541926 142555 63813497
Upper gastrointestinal haemorrhage 96.66 10.35 566 542114 34654 63921398
Pancreatitis acute 96.65 10.35 655 542025 42200 63913852
Muscle necrosis 96.42 10.35 81 542599 1142 63954910
Injection site erythema 96.31 10.35 291 542389 70509 63885543
Blood triglycerides increased 96.04 10.35 363 542317 18503 63937549
Chromaturia 95.88 10.35 411 542269 22200 63933852
Neutrophil count decreased 95.48 10.35 331 542349 76865 63879187
Leukopenia 94.92 10.35 483 542197 100759 63855293
Hyponatraemia 94.62 10.35 1764 540916 146575 63809477
Muscle rupture 93.84 10.35 125 542555 3075 63952977
Cardiac disorder 93.74 10.35 796 541884 55020 63901032
Musculoskeletal stiffness 92.54 10.35 631 542049 122575 63833477
Injection site pain 91.62 10.35 555 542125 110853 63845199
Myelosuppression 91.32 10.35 43 542637 23787 63932265
White blood cell count decreased 89.82 10.35 871 541809 156966 63799086
Erectile dysfunction 89.03 10.35 271 542409 12356 63943696
Respiratory arrest 88.80 10.35 196 542484 52789 63903263
Nasopharyngitis 88.27 10.35 1141 541539 194932 63761120
Rash 86.97 10.35 3071 539609 455478 63500574
Graft versus host disease 86.82 10.35 8 542672 13805 63942247
Ill-defined disorder 86.82 10.35 148 542532 43904 63912148
Ischaemic cardiomyopathy 84.00 10.35 181 542499 6657 63949395
Myocardial necrosis marker increased 83.85 10.35 110 542570 2665 63953387
Renal failure 83.44 10.35 2060 540620 179628 63776424
Autoimmune hepatitis 83.24 10.35 229 542451 9855 63946197
Myopathy toxic 82.68 10.35 64 542616 797 63955255
Arteriosclerosis 82.07 10.35 307 542373 15570 63940482
Caesarean section 81.50 10.35 3 542677 11271 63944781
Neurotoxicity 80.79 10.35 67 542613 27337 63928715
Neurologic neglect syndrome 80.66 10.35 83 542597 1535 63954517
Vascular stent thrombosis 80.21 10.35 119 542561 3245 63952807
High density lipoprotein decreased 79.29 10.35 129 542551 3817 63952235
Oedema peripheral 79.00 10.35 2323 540357 207994 63748058
Carotid artery thrombosis 78.70 10.35 86 542594 1709 63954343
Red blood cell sedimentation rate abnormal 76.79 10.35 21 542659 16285 63939767
Diabetes mellitus inadequate control 75.84 10.35 368 542312 20953 63935099
Carotid artery stenosis 75.40 10.35 190 542490 7751 63948301
C-reactive protein increased 75.34 10.35 478 542202 94431 63861621
Poisoning 74.31 10.35 46 542634 21833 63934219
Faeces discoloured 74.22 10.35 419 542261 25310 63930742
Gastrointestinal disorder 73.70 10.35 447 542233 89262 63866790
Suicide attempt 73.43 10.35 327 542353 70680 63885372
Injection site reaction 72.28 10.35 180 542500 46484 63909568
Tendon rupture 72.13 10.35 227 542453 10540 63945512
Hepatitis acute 71.81 10.35 262 542418 13127 63942925
Haematoma 71.65 10.35 648 542032 45602 63910450
Drug-induced liver injury 71.52 10.35 663 542017 46980 63909072
Therapeutic product effect incomplete 71.39 10.35 543 542137 102939 63853113
Platelet count decreased 71.10 10.35 988 541692 166723 63789329
Coma 69.68 10.35 441 542239 87174 63868878
Mixed liver injury 69.54 10.35 147 542533 5334 63950718
Product substitution issue 69.17 10.35 316 542364 17545 63938507
Product prescribing error 69.05 10.35 521 542159 34748 63921304
Anaemia 68.88 10.35 3869 538811 374811 63581241
Blood loss anaemia 67.19 10.35 263 542417 13629 63942423
Haemophagocytic lymphohistiocytosis 67.13 10.35 32 542648 17577 63938475
Presyncope 66.83 10.35 515 542165 34574 63921478
Cardiac failure chronic 66.54 10.35 197 542483 8844 63947208
Bronchopulmonary aspergillosis 66.40 10.35 39 542641 19046 63937006
Dyspnoea exertional 66.19 10.35 928 541752 72802 63883250
Pneumocystis jirovecii pneumonia 66.12 10.35 81 542599 27553 63928499
Inferior vena cava dilatation 65.85 10.35 53 542627 701 63955351
C-reactive protein abnormal 65.52 10.35 89 542591 28958 63927094
Vascular stent stenosis 64.99 10.35 67 542613 1242 63954810
Muscle atrophy 64.70 10.35 205 542475 9553 63946499
International normalised ratio increased 63.81 10.35 978 541702 78189 63877863
Aspergillus infection 63.62 10.35 29 542651 16350 63939702
Glomerular filtration rate decreased 63.40 10.35 329 542351 19243 63936809
Pathogen resistance 63.26 10.35 14 542666 12529 63943523
Chronic kidney disease 62.05 10.35 753 541927 57166 63898886
Serotonin syndrome 61.25 10.35 151 542529 39131 63916921
Renal impairment 61.11 10.35 1528 541152 133489 63822563
Blood creatine phosphokinase MB increased 60.04 10.35 91 542589 2530 63953522
Injection site swelling 59.87 10.35 165 542515 41188 63914864
Swollen tongue 59.49 10.35 500 542180 34454 63921598
Pemphigoid 58.92 10.35 241 542439 12745 63943307
Haemorrhage intracranial 58.68 10.35 373 542307 23511 63932541
Low density lipoprotein decreased 58.15 10.35 58 542622 1032 63955020
Dermatomyositis 58.11 10.35 93 542587 2713 63953339
Overdose 57.40 10.35 970 541710 158596 63797456
Arteriosclerosis coronary artery 57.38 10.35 271 542409 15258 63940794
Therapeutic response decreased 57.23 10.35 235 542445 51953 63904099
Acute myeloid leukaemia 57.17 10.35 89 542591 27374 63928678
Epstein-Barr virus infection 57.11 10.35 17 542663 12471 63943581
Injection site pruritus 56.97 10.35 148 542532 37678 63918374
Chronic obstructive pulmonary disease 56.23 10.35 875 541805 70173 63885879
Atrioventricular block complete 55.77 10.35 255 542425 14163 63941889
Muscle injury 55.68 10.35 85 542595 26352 63929700
Atrioventricular block 55.32 10.35 224 542456 11791 63944261
Hepatitis 55.26 10.35 607 542073 44975 63911077
Ascites 55.19 10.35 301 542379 61700 63894352
Venoocclusive liver disease 55.14 10.35 9 542671 10006 63946046
Diabetes mellitus 55.04 10.35 825 541855 65649 63890403
Rheumatoid nodule 54.71 10.35 19 542661 12632 63943420
Blister 54.37 10.35 428 542252 80539 63875513
Accidental exposure to product 53.41 10.35 87 542593 26277 63929775
Hypocalcaemia 53.40 10.35 562 542118 41191 63914861
Polymyalgia rheumatica 53.37 10.35 99 542581 3260 63952792
Transplant rejection 53.23 10.35 41 542639 17360 63938692
Amnesia 53.22 10.35 631 542049 47638 63908414
Haematotoxicity 53.02 10.35 21 542659 12875 63943177
Coronary artery restenosis 52.99 10.35 60 542620 1242 63954810
Low density lipoprotein abnormal 52.97 10.35 33 542647 281 63955771
Rheumatic fever 51.96 10.35 8 542672 9286 63946766
Premature labour 51.93 10.35 3 542677 7617 63948435
Immune reconstitution inflammatory syndrome 51.78 10.35 20 542660 12450 63943602
Hip arthroplasty 51.70 10.35 62 542618 21289 63934763
Jaundice 51.66 10.35 630 542050 47882 63908170
Myoglobin blood increased 51.44 10.35 87 542593 2660 63953392
Fibromyalgia 50.66 10.35 144 542536 35587 63920465
Subdural haematoma 50.26 10.35 406 542274 27648 63928404
Cerebral infarction 49.96 10.35 547 542133 40497 63915555
Adenovirus infection 49.01 10.35 3 542677 7252 63948800
Cytokine release syndrome 48.84 10.35 62 542618 20767 63935285
Lymphocyte count decreased 48.65 10.35 177 542503 40522 63915530
Intentional product misuse 48.61 10.35 382 542298 71913 63884139
Cardio-respiratory arrest 47.47 10.35 564 542116 97829 63858223
Migraine 47.04 10.35 321 542359 62356 63893696
Hypotension 47 10.35 3768 538912 377206 63578846
Cardiotoxicity 46.96 10.35 14 542666 10260 63945792
Large intestine polyp 46.73 10.35 198 542482 10639 63945413
Sedation 46.53 10.35 185 542495 41277 63914775
Orthostatic hypotension 46.36 10.35 599 542081 46139 63909913
Progressive multifocal leukoencephalopathy 46.25 10.35 51 542629 18181 63937871
Thrombocytopenia 46.01 10.35 1483 541197 222318 63733734
Knee arthroplasty 45.96 10.35 99 542581 26900 63929152
Ocular myasthenia 45.21 10.35 32 542648 344 63955708
Hypertransaminasaemia 44.90 10.35 148 542532 7043 63949009
N-terminal prohormone brain natriuretic peptide increased 44.63 10.35 95 542585 3464 63952588
Panniculitis 44.60 10.35 10 542670 8869 63947183
Drug ineffective for unapproved indication 44.49 10.35 125 542555 31008 63925044
Muscle disorder 44.46 10.35 116 542564 4835 63951217
Cardiac failure acute 44.42 10.35 262 542418 16082 63939970
Confusional state 44.12 10.35 2651 540029 258493 63697559
Muscle enzyme increased 43.90 10.35 31 542649 332 63955720
Ejection fraction decreased 43.84 10.35 401 542279 28306 63927746
Hepatic enzyme increased 43.82 10.35 799 541881 129144 63826908
Hemiparesis 43.72 10.35 413 542267 29414 63926638
Troponin increased 43.24 10.35 249 542431 15150 63940902
Coronary artery bypass 43.07 10.35 127 542553 5688 63950364
Hyperlipidaemia 43.07 10.35 336 542344 22640 63933412
Multiple-drug resistance 43.00 10.35 3 542677 6499 63949553
Disease progression 42.96 10.35 887 541793 140793 63815259
Angioedema 42.49 10.35 744 541936 61077 63894975
Hemiplegia 42.31 10.35 216 542464 12552 63943500
Nocturia 42.10 10.35 196 542484 10969 63945083
Diabetic nephropathy 41.89 10.35 78 542602 2576 63953476
Pneumonia 41.85 10.35 4097 538583 555479 63400573
Post transplant lymphoproliferative disorder 41.85 10.35 14 542666 9530 63946522
Hyperglycaemia 41.64 10.35 733 541947 60235 63895817
Haemorrhagic stroke 41.51 10.35 180 542500 9771 63946281
Device dislocation 40.95 10.35 72 542608 21106 63934946
Psychotic disorder 40.92 10.35 151 542529 34427 63921625
Enthesopathy 40.78 10.35 15 542665 9623 63946429
Sedation complication 40.74 10.35 18 542662 10336 63945716
Inflammation 40.74 10.35 352 542328 64948 63891104
Myelodysplastic syndrome 40.70 10.35 109 542571 27470 63928582
Computerised tomogram coronary artery abnormal 40.59 10.35 24 542656 184 63955868
Arthralgia 40.42 10.35 3188 539492 439072 63516980
Device issue 40.27 10.35 81 542599 22567 63933485
Pallor 40.15 10.35 501 542179 38280 63917772
Type V hyperlipidaemia 40.12 10.35 44 542636 878 63955174
Adjustment disorder 40.03 10.35 78 542602 2667 63953385
Posterior reversible encephalopathy syndrome 40.01 10.35 83 542597 22863 63933189
Swollen joint count increased 39.98 10.35 8 542672 7681 63948371
Euglycaemic diabetic ketoacidosis 39.93 10.35 118 542562 5292 63950760
Tricuspid valve incompetence 39.60 10.35 262 542418 16741 63939311
Unintentional medical device removal 39.52 10.35 5 542675 6729 63949323
Lower respiratory tract infection 39.49 10.35 559 542121 94055 63861997
Candida infection 39.32 10.35 134 542546 31285 63924767
Electrocardiogram abnormal 39.18 10.35 220 542460 13261 63942791
Disseminated intravascular coagulation 39.12 10.35 140 542540 32208 63923844
Dysarthria 39.08 10.35 710 541970 58696 63897356
Seizure 38.97 10.35 1087 541593 165805 63790247
Weight decreased 38.67 10.35 2847 539833 282892 63673160
Tumour lysis syndrome 38.59 10.35 65 542615 19375 63936677
Cardiac murmur 38.58 10.35 196 542484 11367 63944685
Bone erosion 38.52 10.35 25 542655 11570 63944482
Exercise lack of 38.52 10.35 31 542649 410 63955642
Pre-eclampsia 38.14 10.35 4 542676 6227 63949825
Cholestatic liver injury 38.09 10.35 91 542589 3588 63952464
Blood glucose decreased 37.89 10.35 328 542352 22795 63933257
Loss of personal independence in daily activities 37.82 10.35 408 542272 72046 63884006
Headache 37.59 10.35 3891 538789 525576 63430476
Neoplasm progression 37.49 10.35 197 542483 40767 63915285
Arterial stenosis 37.43 10.35 52 542628 1333 63954719
Hepatic cytolysis 37.40 10.35 224 542456 13825 63942227
Red blood cell sedimentation rate increased 37.23 10.35 136 542544 31099 63924953
Personality disorder 36.93 10.35 105 542575 4606 63951446
Drug use disorder 36.76 10.35 4 542676 6050 63950002
Mydriasis 36.51 10.35 45 542635 15267 63940785
Febrile bone marrow aplasia 36.41 10.35 25 542655 11230 63944822
Hypovolaemic shock 36.37 10.35 177 542503 10089 63945963
Bacteraemia 36.31 10.35 111 542569 26800 63929252
Shock haemorrhagic 36.29 10.35 254 542426 16537 63939515
Haematemesis 36.11 10.35 576 542104 46423 63909629
Death 35.95 10.35 3535 539145 479170 63476882
Ventricular hypokinesia 35.90 10.35 145 542535 7624 63948428
Fungal infection 35.84 10.35 157 542523 34094 63921958
Sepsis 35.65 10.35 1579 541101 228762 63727290
Device related infection 35.43 10.35 135 542545 30491 63925561
Gamma-glutamyltransferase increased 35.22 10.35 589 542091 47921 63908131
Peripheral artery stenosis 35.11 10.35 47 542633 1162 63954890
Uterine perforation 34.95 10.35 4 542676 5816 63950236
Carotid artery occlusion 34.94 10.35 93 542587 3924 63952128
Psoriatic arthropathy 34.84 10.35 217 542463 43064 63912988
Paradoxical drug reaction 34.84 10.35 5 542675 6115 63949937
Tenosynovitis 34.80 10.35 29 542651 11804 63944248
Immunodeficiency 34.78 10.35 51 542629 16073 63939979
Ventricular hypertrophy 34.52 10.35 127 542553 6389 63949663
Urinary retention 34.49 10.35 594 542086 48607 63907445
Left atrial enlargement 34.48 10.35 43 542637 989 63955063
Herpes zoster 34.43 10.35 464 542216 78723 63877329
Enterococcal infection 33.85 10.35 40 542640 13826 63942226
Drug dependence 33.48 10.35 155 542525 33157 63922895
Hepatitis toxic 33.46 10.35 97 542583 4303 63951749
Muscle discomfort 33.38 10.35 18 542662 113 63955939
Exercise tolerance decreased 33.34 10.35 141 542539 7569 63948483
Eosinophilia 33.26 10.35 477 542203 37599 63918453
Amyotrophic lateral sclerosis 33.23 10.35 54 542626 1596 63954456
Idiopathic pulmonary fibrosis 33.07 10.35 88 542592 3712 63952340
Blood cholesterol decreased 32.79 10.35 51 542629 1451 63954601
Haemorrhagic transformation stroke 32.57 10.35 66 542614 2323 63953729
Abortion induced 32.48 10.35 7 542673 6381 63949671
Stent placement 32.44 10.35 112 542568 5459 63950593
Flushing 32.35 10.35 466 542214 78182 63877870
Peripheral vascular disorder 32.35 10.35 134 542546 7127 63948925
Cerebral haematoma 32.33 10.35 133 542547 7052 63949000
Multiple sclerosis relapse 32.21 10.35 208 542472 40927 63915125
Lip swelling 32.10 10.35 410 542270 31497 63924555
Adverse drug reaction 32.09 10.35 237 542443 45227 63910825
Heart rate irregular 31.84 10.35 362 542318 27051 63929001
Mouth swelling 31.79 10.35 105 542575 5002 63951050
Pancreatitis 31.38 10.35 689 541991 58918 63897134
Microcytic anaemia 31.27 10.35 98 542582 4540 63951512
Aortic stenosis 31.19 10.35 121 542559 6244 63949808
Erythema 30.89 10.35 1273 541407 185797 63770255
Aortic aneurysm 30.83 10.35 136 542544 7438 63948614
Hypertensive crisis 30.50 10.35 260 542420 17988 63938064
Exposure via ingestion 30.38 10.35 3 542677 4899 63951153
Atrial flutter 30.25 10.35 272 542408 19108 63936944
Abnormal loss of weight 30.21 10.35 133 542547 7267 63948785
Oropharyngeal pain 30.09 10.35 546 542134 88321 63867731
Ventricular enlargement 30.08 10.35 29 542651 494 63955558
Device adhesion issue 30.08 10.35 4 542676 5182 63950870
Aplastic anaemia 30.05 10.35 44 542636 13876 63942176
Subarachnoid haemorrhage 29.93 10.35 261 542419 18177 63937875
Acute respiratory distress syndrome 29.91 10.35 198 542482 38737 63917315
Dystonia 29.82 10.35 72 542608 18793 63937259
Incorrect dosage administered 29.76 10.35 61 542619 2165 63953887
Amenorrhoea 29.73 10.35 9 542671 6530 63949522
Peripheral arterial occlusive disease 29.62 10.35 127 542553 6860 63949192
Blood cholesterol abnormal 29.59 10.35 68 542612 2613 63953439
Substance abuse 29.58 10.35 21 542659 9271 63946781
Cystitis haemorrhagic 29.51 10.35 15 542665 7941 63948111
Blood urea abnormal 29.19 10.35 43 542637 1165 63954887
Gout 29.18 10.35 292 542388 21121 63934931
Gynaecomastia 29.18 10.35 114 542566 5902 63950150
Dehydration 29.18 10.35 2159 540521 214604 63741448
Foetal death 29.15 10.35 7 542673 5923 63950129
Aphasia 29.08 10.35 495 542185 40411 63915641
Intermittent claudication 28.92 10.35 73 542607 2981 63953071
Cytomegalovirus viraemia 28.91 10.35 29 542651 10799 63945253
Cardiomyopathy 28.62 10.35 333 542347 25023 63931029
Pain in extremity 28.54 10.35 2940 539740 300145 63655907
Human herpesvirus 6 infection 28.45 10.35 3 542677 4651 63951401
Cardiac aneurysm 28.21 10.35 44 542636 1255 63954797
Head injury 28.12 10.35 410 542270 32432 63923620
Myasthenia gravis 28.05 10.35 109 542571 5629 63950423
Therapy partial responder 27.88 10.35 27 542653 10221 63945831
Palmar-plantar erythrodysaesthesia syndrome 27.85 10.35 136 542544 28683 63927369
Labile blood pressure 27.81 10.35 57 542623 2023 63954029
Neuroleptic malignant syndrome 27.75 10.35 112 542568 24884 63931168
Sensory loss 27.62 10.35 163 542517 10006 63946046
Duodenal ulcer 27.56 10.35 212 542468 14223 63941829
Pericardial haemorrhage 27.52 10.35 87 542593 4049 63952003
Carotid artery disease 27.43 10.35 58 542622 2105 63953947
Angiopathy 27.43 10.35 115 542565 6150 63949902
Food allergy 27.37 10.35 16 542664 7835 63948217
Flatulence 27.36 10.35 437 542243 35229 63920823
Lower gastrointestinal haemorrhage 27.33 10.35 206 542474 13733 63942319
Mobility decreased 27.33 10.35 533 542147 85307 63870745
Spur cell anaemia 27.31 10.35 14 542666 78 63955974
Hypercholesterolaemia 27.28 10.35 222 542458 15151 63940901
Heavy menstrual bleeding 27.24 10.35 37 542643 12040 63944012
Injection site bruising 26.93 10.35 187 542493 36186 63919866
Sinus bradycardia 26.90 10.35 303 542377 22590 63933462
Disability 26.74 10.35 38 542642 12134 63943918
Injection site warmth 26.73 10.35 45 542635 13417 63942635
Drug withdrawal syndrome 26.71 10.35 154 542526 31137 63924915
Oral herpes 26.70 10.35 96 542584 22056 63933996
Degenerative mitral valve disease 26.65 10.35 20 542660 237 63955815
Tachycardia 26.61 10.35 1009 541671 148570 63807482
Acne 26.53 10.35 102 542578 22979 63933073
Suicidal ideation 26.42 10.35 397 542283 66145 63889907
Metastases to central nervous system 26.27 10.35 48 542632 13864 63942188
Drug tolerance decreased 26.25 10.35 13 542667 6985 63949067
Akathisia 26.23 10.35 35 542645 11475 63944577
Scrotal pain 26.12 10.35 25 542655 422 63955630
Incorrect route of product administration 26.11 10.35 104 542576 23194 63932858
Cytomegalovirus infection reactivation 26.03 10.35 8 542672 5748 63950304
Neutropenic colitis 25.48 10.35 4 542676 4577 63951475
Appendicitis 25.46 10.35 47 542633 13522 63942530
Penile haemorrhage 25.26 10.35 26 542654 481 63955571
Genital swelling 25.18 10.35 21 542659 293 63955759
Agitation 25.10 10.35 559 542121 87808 63868244
Poisoning deliberate 24.91 10.35 47 542633 13411 63942641
Cardiac valve disease 24.84 10.35 98 542582 5097 63950955
Clostridium difficile infection 24.81 10.35 190 542490 35973 63920079
Eructation 24.76 10.35 147 542533 9044 63947008
Psoriasis 24.74 10.35 784 541896 70919 63885133
Nocardiosis 24.70 10.35 5 542675 4762 63951290
Type 2 diabetes mellitus 24.67 10.35 413 542267 33607 63922445
Stenosis 24.58 10.35 50 542630 1765 63954287
Interstitial lung disease 24.53 10.35 1031 541649 96701 63859351
Balance disorder 24.50 10.35 900 541780 83026 63873026
Complication of device insertion 24.47 10.35 6 542674 5006 63951046
Dermatitis atopic 24.40 10.35 80 542600 3796 63952256
Grip strength decreased 24.40 10.35 38 542642 11686 63944366
Menstruation irregular 24.38 10.35 4 542676 4431 63951621
Inclusion body myositis 24.34 10.35 8 542672 9 63956043
Depressed level of consciousness 24.33 10.35 511 542169 80925 63875127
Basal ganglia haemorrhage 24.33 10.35 43 542637 1363 63954689
Epistaxis 24.13 10.35 1033 541647 97098 63858954
Pneumatosis intestinalis 24.13 10.35 7 542673 5222 63950830
Herpes simplex 24.05 10.35 32 542648 10504 63945548
Cell death 24.04 10.35 82 542598 3972 63952080
Arterial occlusive disease 24.02 10.35 120 542560 6913 63949139
Cardiogenic shock 24.01 10.35 395 542285 32032 63924020
Septic shock 23.77 10.35 690 541990 104747 63851305
Tuberculosis 23.72 10.35 46 542634 12992 63943060
Quadriparesis 23.70 10.35 65 542615 2792 63953260
Hypertension 23.70 10.35 2510 540170 256751 63699301
Post viral fatigue syndrome 23.69 10.35 20 542660 284 63955768
Encephalopathy 23.67 10.35 350 542330 58469 63897583
Gastritis erosive 23.66 10.35 150 542530 9445 63946607
Acute lymphocytic leukaemia recurrent 23.60 10.35 3 542677 4023 63952029
Diabetic foot 23.58 10.35 67 542613 2938 63953114
Aggression 23.46 10.35 262 542418 45970 63910082
Aldolase increased 23.40 10.35 18 542662 222 63955830
Neuropathy peripheral 23.36 10.35 782 541898 116743 63839309
Tongue oedema 23.21 10.35 106 542574 5884 63950168
Prostatomegaly 23.13 10.35 66 542614 2901 63953151
Blood parathyroid hormone decreased 22.99 10.35 17 542663 7349 63948703
Diabetic retinopathy 22.96 10.35 64 542616 2775 63953277
Therapy non-responder 22.90 10.35 403 542277 65496 63890556
Nodule 22.83 10.35 76 542604 17871 63938181
Urinary tract obstruction 22.73 10.35 80 542600 3937 63952115
Lichen planopilaris 22.72 10.35 6 542674 0 63956052
Blood electrolytes abnormal 22.68 10.35 48 542632 1743 63954309
Blood creatine phosphokinase abnormal 22.67 10.35 22 542658 378 63955674
Ketoacidosis 22.67 10.35 116 542564 6747 63949305
Ageusia 22.66 10.35 196 542484 13617 63942435
Diabetic metabolic decompensation 22.56 10.35 62 542618 2666 63953386
Urticaria 22.54 10.35 1011 541669 146306 63809746
Juvenile idiopathic arthritis 22.48 10.35 3 542677 3876 63952176
Benign prostatic hyperplasia 22.43 10.35 143 542537 9022 63947030
Gait disturbance 22.37 10.35 1710 540970 170445 63785607
Dementia 22.24 10.35 270 542410 20496 63935556
Blood pressure fluctuation 22.16 10.35 305 542375 51566 63904486
Carotid arteriosclerosis 22.15 10.35 52 542628 2027 63954025
Diverticulum 22.03 10.35 188 542492 13010 63943042
Multiple organ dysfunction syndrome 22.03 10.35 667 542013 100746 63855306
Penis injury 22.02 10.35 14 542666 124 63955928
Lipoprotein (a) increased 21.94 10.35 11 542669 58 63955994
Vertigo 21.89 10.35 651 542029 58360 63897692
Pseudomonas infection 21.89 10.35 77 542603 17806 63938246
Adrenal insufficiency 21.79 10.35 106 542574 22381 63933671
Metastases to bone 21.79 10.35 93 542587 20342 63935710
Hepatic encephalopathy 21.78 10.35 97 542583 20969 63935083
Dyspnoea at rest 21.62 10.35 108 542572 6221 63949831
Acquired claw toe 21.55 10.35 12 542668 81 63955971
Brain oedema 21.43 10.35 104 542576 21971 63934081
Product complaint 21.41 10.35 173 542507 11781 63944271
Neutropenic sepsis 21.25 10.35 112 542568 23160 63932892
Intraventricular haemorrhage 21.21 10.35 80 542600 4073 63951979
Injection site rash 21.19 10.35 65 542615 15677 63940375
Retinal artery occlusion 21.12 10.35 63 542617 2840 63953212
Abnormal weight gain 21.06 10.35 53 542627 2160 63953892
Generalised tonic-clonic seizure 20.97 10.35 224 542456 39633 63916419
Ventricular tachycardia 20.97 10.35 405 542275 33860 63922192
Muscle haemorrhage 20.97 10.35 100 542580 5653 63950399
Acute left ventricular failure 20.95 10.35 40 542640 1347 63954705
Staphylococcal infection 20.94 10.35 300 542380 50378 63905674
Pulmonary vascular disorder 20.92 10.35 32 542648 897 63955155
Ovarian cyst 20.82 10.35 38 542642 10980 63945072
Restlessness 20.77 10.35 224 542456 39561 63916491
Hypercalcaemia 20.65 10.35 167 542513 31249 63924803
Temperature regulation disorder 20.64 10.35 5 542675 4206 63951846
Joint destruction 20.63 10.35 3 542677 3633 63952419
Stillbirth 20.60 10.35 3 542677 3630 63952422
Dysuria 20.53 10.35 481 542199 41576 63914476
Blood cholesterol 20.50 10.35 20 542660 346 63955706
Status epilepticus 20.49 10.35 103 542577 21560 63934492
Arterial insufficiency 20.47 10.35 19 542661 308 63955744
Chest discomfort 20.40 10.35 1183 541497 114923 63841129
Traumatic coma 20.37 10.35 10 542670 50 63956002
Drug specific antibody present 20.21 10.35 9 542671 5145 63950907
Macroglossia 20.14 10.35 34 542646 1038 63955014
Neuromyopathy 20.10 10.35 39 542641 1329 63954723
Vascular purpura 20.07 10.35 57 542623 2499 63953553
Lacunar infarction 20.04 10.35 96 542584 5436 63950616
Coronary artery surgery 20.04 10.35 15 542665 177 63955875
Hepatitis B reactivation 20.04 10.35 8 542672 4881 63951171
Eating disorder 20.00 10.35 223 542457 16582 63939470
Infarction 19.99 10.35 76 542604 3884 63952168
Agitated depression 19.94 10.35 18 542662 281 63955771
Crying 19.88 10.35 94 542586 19996 63936056
Urinary tract discomfort 19.74 10.35 19 542661 323 63955729
Chest wall haematoma 19.73 10.35 20 542660 363 63955689
Transaminases increased 19.66 10.35 503 542177 44091 63911961
Bacterial infection 19.61 10.35 126 542554 24824 63931228
Central obesity 19.60 10.35 40 542640 1415 63954637
Obstructive pancreatitis 19.60 10.35 26 542654 637 63955415
Hyperprolactinaemia 19.59 10.35 5 542675 4060 63951992
Polyuria 19.50 10.35 177 542503 12466 63943586
Vascular graft occlusion 19.48 10.35 26 542654 641 63955411
Gastrointestinal angiodysplasia 19.43 10.35 31 542649 902 63955150
Inappropriate antidiuretic hormone secretion 19.37 10.35 279 542401 22010 63934042
Hepatojugular reflux 19.30 10.35 23 542657 504 63955548
Metastases to liver 19.28 10.35 120 542560 23821 63932231
Narrow anterior chamber angle 19.22 10.35 14 542666 158 63955894
Klebsiella infection 19.21 10.35 53 542627 13228 63942824
Anticoagulation drug level increased 19.11 10.35 26 542654 653 63955399
Vascular stent occlusion 19.10 10.35 15 542665 191 63955861
Peripheral artery occlusion 19.10 10.35 50 542630 2088 63953964
Lacunar stroke 19.06 10.35 17 542663 261 63955791
Hypogammaglobulinaemia 19.03 10.35 36 542644 10263 63945789
Bundle branch block left 18.95 10.35 147 542533 9887 63946165
Blood pressure increased 18.91 10.35 1692 540988 170860 63785192
Myoglobinaemia 18.90 10.35 12 542668 106 63955946
Sopor 18.89 10.35 159 542521 29502 63926550
Memory impairment 18.89 10.35 892 541788 84790 63871262
Aortic valve incompetence 18.78 10.35 127 542553 8174 63947878
Cytopenia 18.68 10.35 67 542613 15404 63940648
Primary biliary cholangitis 18.67 10.35 32 542648 989 63955063
Decreased appetite 18.62 10.35 2669 540011 278620 63677432
AST/ALT ratio abnormal 18.61 10.35 7 542673 15 63956037
Occupational problem environmental 18.61 10.35 6 542674 6 63956046
Avoidant personality disorder 18.61 10.35 6 542674 6 63956046
Catatonia 18.58 10.35 22 542658 7598 63948454
Embolic stroke 18.51 10.35 108 542572 6603 63949449
Cholecystitis chronic 18.48 10.35 31 542649 9256 63946796
Hallucination, gustatory 18.39 10.35 10 542670 64 63955988
Device difficult to use 18.33 10.35 34 542646 9764 63946288
Thrombotic microangiopathy 18.25 10.35 75 542605 16580 63939472
Atrial enlargement 18.17 10.35 25 542655 635 63955417
Alveolar osteitis 18.12 10.35 20 542660 402 63955650
Escherichia infection 18.10 10.35 66 542614 15102 63940950
Respiratory failure 18.09 10.35 1141 541539 160042 63796010
Diabetic neuropathy 18.03 10.35 94 542586 5507 63950545
Aortic valve replacement 18.01 10.35 34 542646 1135 63954917
Cervix neoplasm 17.98 10.35 14 542666 176 63955876
Motor dysfunction 17.94 10.35 160 542520 11213 63944839
Atrioventricular block second degree 17.89 10.35 104 542576 6350 63949702
Glycogen storage disease type V 17.88 10.35 8 542672 31 63956021
Transplant dysfunction 17.87 10.35 18 542662 6690 63949362
Myoglobinuria 17.84 10.35 31 542649 969 63955083
Dyslipidaemia 17.79 10.35 136 542544 9106 63946946
Arrhythmia 17.77 10.35 577 542103 52367 63903685
Weight increased 17.75 10.35 1549 541131 211799 63744253
Cardiovascular disorder 17.67 10.35 208 542472 15673 63940379
Deafness 17.66 10.35 234 542446 18125 63937927
Periorbital haematoma 17.61 10.35 29 542651 867 63955185
Pulmonary tuberculosis 17.58 10.35 21 542659 7223 63948829
Atrial thrombosis 17.57 10.35 61 542619 2981 63953071
Gastroduodenal haemorrhage 17.56 10.35 16 542664 253 63955799
Potassium wasting nephropathy 17.54 10.35 13 542667 151 63955901
Coeliac disease 17.44 10.35 22 542658 7390 63948662
Gastritis 17.43 10.35 476 542204 42142 63913910
Injection site haemorrhage 17.40 10.35 126 542554 24152 63931900
Orthopnoea 17.35 10.35 134 542546 9000 63947052
Body height decreased 17.35 10.35 116 542564 7438 63948614
Left atrial dilatation 17.33 10.35 57 542623 2709 63953343
Muscle fatigue 17.31 10.35 61 542619 3004 63953048
Essential hypertension 17.30 10.35 88 542592 5106 63950946
ECG signs of myocardial ischaemia 17.15 10.35 18 542662 341 63955711
Peripheral ischaemia 17.10 10.35 125 542555 8253 63947799
Pollakiuria 17.08 10.35 366 542314 31164 63924888
Dyspnoea paroxysmal nocturnal 17.03 10.35 46 542634 1958 63954094
Blood alkaline phosphatase increased 17.03 10.35 606 542074 55673 63900379
Pelvic mass 16.95 10.35 32 542648 1068 63954984
Ventricular dyskinesia 16.94 10.35 19 542661 389 63955663
Angiocardiogram 16.94 10.35 15 542665 228 63955824
Diffuse large B-cell lymphoma recurrent 16.94 10.35 3 542677 3143 63952909
Lichenoid keratosis 16.84 10.35 64 542616 3270 63952782
Oligohydramnios 16.77 10.35 3 542677 3121 63952931
Hepatocellular carcinoma 16.77 10.35 28 542652 8375 63947677
Anuria 16.73 10.35 238 542442 18726 63937326
Hepatic vein dilatation 16.67 10.35 15 542665 233 63955819
Iliac artery stenosis 16.62 10.35 11 542669 105 63955947
Blood lactic acid 16.61 10.35 20 542660 443 63955609
Pulmonary valve incompetence 16.60 10.35 40 542640 1586 63954466
Blood creatine increased 16.59 10.35 122 542558 8070 63947982
Spinal epidural haematoma 16.56 10.35 34 542646 1208 63954844
Dysstasia 16.53 10.35 281 542399 22934 63933118
Creatinine renal clearance decreased 16.40 10.35 64 542616 14357 63941695
Multiple injuries 16.40 10.35 63 542617 3236 63952816
Gastric ulcer 16.39 10.35 351 542329 29883 63926169
Pneumonia cytomegaloviral 16.36 10.35 8 542672 4331 63951721
Penile pain 16.30 10.35 28 542652 867 63955185
Glomerular filtration rate abnormal 16.24 10.35 34 542646 1225 63954827
Blood potassium increased 16.21 10.35 308 542372 25672 63930380
Coronary artery thrombosis 16.12 10.35 57 542623 2812 63953240
Haematoma muscle 16.09 10.35 42 542638 1751 63954301
Lymphadenopathy 16.06 10.35 286 542394 46400 63909652
Affect lability 16.04 10.35 130 542550 8860 63947192
Skin necrosis 16.04 10.35 64 542616 14265 63941787
Blood glucose abnormal 15.97 10.35 129 542551 8784 63947268
Cardiac pacemaker insertion 15.97 10.35 84 542596 4939 63951113
Ludwig angina 15.96 10.35 14 542666 210 63955842
Therapeutic drug monitoring analysis not performed 15.95 10.35 33 542647 1179 63954873
Occult blood positive 15.95 10.35 99 542581 6188 63949864
Ventricular internal diameter abnormal 15.94 10.35 12 542668 143 63955909
Ventricular extrasystoles 15.87 10.35 221 542459 17308 63938744
Prostate cancer recurrent 15.85 10.35 25 542655 720 63955332
Peripheral nerve palsy 15.83 10.35 8 542672 43 63956009
Hepatosplenomegaly 15.83 10.35 13 542667 5330 63950722
Gastric ulcer haemorrhage 15.77 10.35 120 542560 8023 63948029
Drug screen positive 15.69 10.35 15 542665 5714 63950338
Electrolyte imbalance 15.66 10.35 299 542381 24944 63931108
Blood cholesterol increased 15.62 10.35 541 542139 49525 63906527
Hypoalbuminaemia 15.61 10.35 86 542594 17588 63938464
Ear infection 15.57 10.35 124 542556 23280 63932772
Eye injury 15.57 10.35 39 542641 1585 63954467
Vaginal haemorrhage 15.56 10.35 97 542583 19247 63936805
Intracranial haematoma 15.56 10.35 26 542654 787 63955265
Pain in jaw 15.55 10.35 245 542435 40510 63915542
Autoimmune myocarditis 15.49 10.35 15 542665 257 63955795
Drug tolerance 15.46 10.35 17 542663 6068 63949984
Device use error 15.44 10.35 19 542661 6452 63949600
Radiculitis brachial 15.44 10.35 9 542671 67 63955985
Disease recurrence 15.43 10.35 180 542500 31330 63924722
Renal injury 15.41 10.35 198 542482 15231 63940821
Urinary occult blood positive 15.40 10.35 12 542668 151 63955901
Intestinal haemorrhage 15.38 10.35 89 542591 5425 63950627
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.36 10.35 57 542623 2879 63953173
Clonus 15.36 10.35 17 542663 6050 63950002
Diverticulum intestinal 15.31 10.35 111 542569 7309 63948743
Hepatitis B 15.28 10.35 26 542654 7719 63948333
Heart valve incompetence 15.27 10.35 55 542625 2738 63953314
Blood sodium decreased 15.26 10.35 340 542340 29142 63926910
Upper respiratory tract infection 15.25 10.35 481 542199 72304 63883748
Bilirubin conjugated abnormal 15.24 10.35 10 542670 94 63955958
Blood creatinine abnormal 15.23 10.35 72 542608 4055 63951997
Subacute cutaneous lupus erythematosus 15.23 10.35 58 542622 2967 63953085
Nodular rash 15.21 10.35 16 542664 304 63955748
Second primary malignancy 15.18 10.35 53 542627 12284 63943768
Vascular graft 15.13 10.35 42 542638 1817 63954235
Cerebral microangiopathy 15.13 10.35 14 542666 226 63955826
Blood pressure inadequately controlled 15.08 10.35 87 542593 5297 63950755
Joint range of motion decreased 15.04 10.35 98 542582 19245 63936807
Mitral valve calcification 14.96 10.35 35 542645 1361 63954691
Vascular device infection 14.90 10.35 18 542662 6162 63949890
Hepatic ischaemia 14.85 10.35 29 542651 993 63955059
Dilatation atrial 14.85 10.35 63 542617 3387 63952665
Leukocyturia 14.81 10.35 37 542643 1501 63954551
Rhinovirus infection 14.77 10.35 18 542662 6138 63949914
Parainfluenzae virus infection 14.73 10.35 11 542669 4732 63951320
Product odour abnormal 14.72 10.35 31 542649 1122 63954930
Sarcopenia 14.71 10.35 17 542663 360 63955692
Cold sweat 14.71 10.35 207 542473 16248 63939804
Calcium deficiency 14.66 10.35 24 542656 714 63955338
Pruritus genital 14.66 10.35 29 542651 1003 63955049
Rectal polyp 14.65 10.35 33 542647 1251 63954801
Encephalitis toxic 14.64 10.35 15 542665 276 63955776
Rales 14.61 10.35 194 542486 15035 63941017
Muscle relaxant therapy 14.59 10.35 12 542668 164 63955888
Sinus node dysfunction 14.59 10.35 103 542577 6725 63949327
Penile discharge 14.58 10.35 7 542673 33 63956019
Device deployment issue 14.57 10.35 3 542677 2823 63953229
Aortic valve thickening 14.55 10.35 6 542674 18 63956034
Collagen disorder 14.50 10.35 14 542666 239 63955813
Fear of injection 14.49 10.35 17 542663 5895 63950157
Drug level decreased 14.43 10.35 49 542631 11454 63944598
Glycosylated haemoglobin abnormal 14.41 10.35 11 542669 134 63955918
Conjunctivitis 14.41 10.35 106 542574 20248 63935804
Lymphoproliferative disorder 14.41 10.35 13 542667 5090 63950962
Mood swings 14.36 10.35 87 542593 17381 63938671
Bladder sphincter atony 14.32 10.35 10 542670 105 63955947
Injection site extravasation 14.31 10.35 29 542651 8057 63947995
Peroneal nerve injury 14.24 10.35 8 542672 55 63955997
Prostatic operation 14.24 10.35 13 542667 206 63955846
Helicobacter test positive 14.23 10.35 29 542651 1025 63955027
Hallucinations, mixed 14.20 10.35 18 542662 6034 63950018
Infective exacerbation of chronic obstructive airways disease 14.18 10.35 49 542631 2389 63953663
Aortic valve stenosis 14.15 10.35 76 542604 4504 63951548
Benign gastrointestinal neoplasm 14.14 10.35 11 542669 138 63955914
Liver palpable 14.14 10.35 16 542664 331 63955721
Skin toxicity 14.12 10.35 21 542659 6581 63949471
Metabolic acidosis 14.04 10.35 731 541949 70227 63885825
Pelvic pain 14.02 10.35 46 542634 10864 63945188
Abnormal dreams 14.00 10.35 141 542539 10215 63945837
Blood iron decreased 13.94 10.35 160 542520 11982 63944070
Blood creatinine increased 13.90 10.35 1325 541355 134457 63821595
Product administered to patient of inappropriate age 13.87 10.35 11 542669 4590 63951462
Iron deficiency anaemia 13.83 10.35 260 542420 21629 63934423
Subchondral insufficiency fracture 13.79 10.35 8 542672 59 63955993
Pulmonary haemorrhage 13.77 10.35 60 542620 13049 63943003
Acute lymphocytic leukaemia 13.76 10.35 10 542670 4361 63951691
Tobacco abuse 13.74 10.35 25 542655 811 63955241
Brain stem haematoma 13.72 10.35 10 542670 113 63955939
Sitting disability 13.70 10.35 11 542669 145 63955907
Prothrombin consumption time prolonged 13.65 10.35 7 542673 39 63956013
Non-cardiac chest pain 13.64 10.35 122 542558 8558 63947494
Accelerated hypertension 13.62 10.35 21 542659 593 63955459
Lipids increased 13.55 10.35 34 542646 1383 63954669
Right ventricular enlargement 13.53 10.35 19 542661 492 63955560
Cough decreased 13.52 10.35 5 542675 10 63956042
Blood testosterone decreased 13.50 10.35 44 542636 2081 63953971
Discoloured vomit 13.50 10.35 30 542650 1127 63954925
Lymph node calcification 13.50 10.35 15 542665 304 63955748
Meningitis aseptic 13.49 10.35 17 542663 5713 63950339
Left ventricular dysfunction 13.48 10.35 209 542471 16745 63939307
Wrong technique in product usage process 13.46 10.35 430 542250 64544 63891508
Quadrantanopia 13.41 10.35 12 542668 185 63955867
Coronary angioplasty 13.41 10.35 16 542664 351 63955701
Device breakage 13.38 10.35 34 542646 8721 63947331
Stevens-Johnson syndrome 13.36 10.35 205 542475 34044 63922008
Ankylosing spondylitis 13.35 10.35 31 542649 8203 63947849
Duodenal ulcer haemorrhage 13.27 10.35 95 542585 6230 63949822
Haemoglobin increased 13.26 10.35 82 542598 5119 63950933
Photophobia 13.25 10.35 88 542592 17205 63938847
Normocytic anaemia 13.25 10.35 59 542621 3240 63952812
Burning feet syndrome 13.22 10.35 10 542670 120 63955932
Anal abscess 13.22 10.35 27 542653 7481 63948571
Internal haemorrhage 13.22 10.35 110 542570 7557 63948495
Decreased gait velocity 13.22 10.35 11 542669 153 63955899
Thrombotic thrombocytopenic purpura 13.21 10.35 91 542589 5893 63950159
Ear congestion 13.20 10.35 44 542636 2106 63953946
Ecchymosis 13.19 10.35 178 542502 13844 63942208
Prostate cancer 13.16 10.35 237 542443 19558 63936494
Laryngeal haematoma 13.16 10.35 11 542669 154 63955898
Subdural haemorrhage 13.14 10.35 83 542597 5220 63950832
Pulmonary renal syndrome 13.12 10.35 20 542660 559 63955493
Hepatitis C 13.10 10.35 48 542632 10967 63945085
Tic 13.05 10.35 3 542677 2616 63953436
Agonal rhythm 13.05 10.35 8 542672 66 63955986
Respiratory acidosis 13.04 10.35 41 542639 9814 63946238
Wound haematoma 13.04 10.35 11 542669 156 63955896
Cholangiocarcinoma 13.02 10.35 42 542638 1976 63954076
Kidney transplant rejection 12.99 10.35 39 542641 9472 63946580
Hypokalaemia 12.99 10.35 1193 541487 120710 63835342
Benign pancreatic neoplasm 12.97 10.35 7 542673 44 63956008
Epstein-Barr virus associated lymphoproliferative disorder 12.95 10.35 5 542675 3114 63952938
Nicotine dependence 12.94 10.35 24 542656 790 63955262
Post stroke epilepsy 12.93 10.35 4 542676 3 63956049
Post stroke seizure 12.93 10.35 4 542676 3 63956049
Femoral bruit 12.91 10.35 5 542675 12 63956040
Phimosis 12.89 10.35 17 542663 414 63955638
Immune effector cell-associated neurotoxicity syndrome 12.88 10.35 3 542677 2592 63953460
Toe amputation 12.87 10.35 61 542619 3439 63952613
Pneumonia aspiration 12.83 10.35 390 542290 58881 63897171
Blood glucose fluctuation 12.82 10.35 90 542590 5865 63950187
Consciousness fluctuating 12.80 10.35 36 542644 1569 63954483
BK virus infection 12.76 10.35 27 542653 7385 63948667
Prolonged expiration 12.76 10.35 24 542656 799 63955253
Fibrous histiocytoma 12.76 10.35 19 542661 520 63955532
Bradyarrhythmia 12.75 10.35 64 542616 3694 63952358
Aortic arteriosclerosis 12.75 10.35 107 542573 7369 63948683
Primary hypoparathyroidism 12.72 10.35 6 542674 27 63956025
Xyphoid retraction 12.70 10.35 11 542669 162 63955890
Testicular pain 12.62 10.35 38 542642 1722 63954330
Shock 12.61 10.35 236 542444 38004 63918048
Urine flow decreased 12.58 10.35 27 542653 990 63955062
Troponin T increased 12.58 10.35 46 542634 2307 63953745
Ileus 12.52 10.35 128 542552 22838 63933214
Arteriovenous fistula occlusion 12.49 10.35 19 542661 530 63955522
Anaphylactic reaction 12.47 10.35 462 542218 68202 63887850
Breast cancer metastatic 12.44 10.35 26 542654 7143 63948909
Soft tissue disorder 12.42 10.35 6 542674 3270 63952782
Copper metabolism disorder 12.41 10.35 4 542676 4 63956048
Biliary fibrosis 12.41 10.35 4 542676 4 63956048
Patient dissatisfaction with treatment 12.38 10.35 10 542670 133 63955919
Acute myeloid leukaemia recurrent 12.36 10.35 4 542676 2780 63953272
Blood triglycerides decreased 12.33 10.35 11 542669 169 63955883
Carcinoid tumour of the gastrointestinal tract 12.30 10.35 8 542672 74 63955978
Alanine aminotransferase increased 12.26 10.35 1343 541337 137688 63818364
Tongue disorder 12.26 10.35 56 542624 12024 63944028
Intestinal obstruction 12.26 10.35 223 542457 36063 63919989
Pharyngitis streptococcal 12.24 10.35 35 542645 8633 63947419
Peripheral coldness 12.19 10.35 171 542509 13413 63942639
Pelvic cyst 12.13 10.35 7 542673 51 63956001
Nightmare 12.13 10.35 246 542434 20747 63935305
Atrioventricular block first degree 12.13 10.35 141 542539 10593 63945459
Portosplenomesenteric venous thrombosis 12.13 10.35 5 542675 15 63956037
Palpitations 12.12 10.35 1029 541651 103459 63852593
Neurosensory hypoacusis 12.10 10.35 12 542668 212 63955840
Toxic epidermal necrolysis 12.06 10.35 230 542450 36936 63919116
Total cholesterol/HDL ratio increased 12.05 10.35 12 542668 213 63955839
Secondary immunodeficiency 11.94 10.35 4 542676 2720 63953332
Cardiac flutter 11.93 10.35 68 542612 4121 63951931
Complication associated with device 11.93 10.35 76 542604 15004 63941048
Device malfunction 11.93 10.35 93 542587 17540 63938512
Scleritis 11.92 10.35 5 542675 2961 63953091
Subcutaneous abscess 11.89 10.35 26 542654 7027 63949025
Dizziness postural 11.88 10.35 130 542550 9622 63946430
Asphyxia 11.83 10.35 41 542639 9525 63946527
Haemarthrosis 11.83 10.35 80 542600 5149 63950903
Mitochondrial toxicity 11.81 10.35 4 542676 2702 63953350
Food interaction 11.81 10.35 33 542647 1433 63954619
Acute pulmonary oedema 11.80 10.35 162 542518 12647 63943405
Toxic anterior segment syndrome 11.75 10.35 3 542677 2436 63953616
Deep vein thrombosis 11.72 10.35 745 541935 104437 63851615
Osteoporosis 11.71 10.35 267 542413 41813 63914239
Pneumonia fungal 11.70 10.35 37 542643 8840 63947212
International normalised ratio abnormal 11.70 10.35 77 542603 4911 63951141
Liver disorder 11.67 10.35 555 542125 52796 63903256
Arthritis 11.66 10.35 581 542099 83233 63872819
Aortic aneurysm rupture 11.63 10.35 29 542651 1175 63954877
Haemorrhage 11.63 10.35 796 541884 78555 63877497
Hypovolaemia 11.60 10.35 189 542491 15297 63940755
Hiatus hernia 11.58 10.35 234 542446 19723 63936329
Dry eye 11.56 10.35 173 542507 28846 63927206
Erythema nodosum 11.54 10.35 10 542670 3994 63952058
Nipple swelling 11.53 10.35 4 542676 6 63956046
Renal disorder 11.50 10.35 384 542296 34981 63921071
Unintended pregnancy 11.49 10.35 6 542674 3128 63952924
Blood calcitonin increased 11.48 10.35 6 542674 35 63956017
Dislocation of vertebra 11.42 10.35 6 542674 3118 63952934
Device related sepsis 11.42 10.35 16 542664 5139 63950913
Immunosuppression 11.40 10.35 49 542631 10697 63945355
Platelet aggregation test 11.39 10.35 7 542673 58 63955994
Mixed anxiety and depressive disorder 11.38 10.35 11 542669 188 63955864
Onychomadesis 11.37 10.35 5 542675 2879 63953173
Bacterial sepsis 11.36 10.35 29 542651 7428 63948624
Wrong dosage form 11.36 10.35 3 542677 0 63956052
Red blood cell acanthocytes present 11.36 10.35 3 542677 0 63956052
Progressive muscular atrophy 11.36 10.35 3 542677 0 63956052
Leukocyte alkaline phosphatase increased 11.36 10.35 3 542677 0 63956052
Implantable cardiac monitor insertion 11.36 10.35 3 542677 0 63956052
Aortitis salmonella 11.36 10.35 3 542677 0 63956052
Foreign travel 11.36 10.35 3 542677 0 63956052
Systemic candida 11.35 10.35 17 542663 5312 63950740
Eyelid retraction 11.35 10.35 6 542674 36 63956016
Prevertebral soft tissue swelling of cervical space 11.35 10.35 6 542674 36 63956016
Cardiac discomfort 11.34 10.35 27 542653 1062 63954990
Encephalitis viral 11.33 10.35 3 542677 2377 63953675
Diverticulum intestinal haemorrhagic 11.32 10.35 56 542624 3213 63952839
Hyperglycaemic hyperosmolar nonketotic syndrome 11.29 10.35 36 542644 1683 63954369
Blood magnesium decreased 11.28 10.35 172 542508 13733 63942319
Duodenitis 11.24 10.35 96 542584 6645 63949407
Pyonephrosis 11.23 10.35 8 542672 87 63955965
Hepatic steatosis 11.21 10.35 341 542339 30666 63925386
Renal cyst 11.19 10.35 158 542522 12412 63943640
Oesophageal adenocarcinoma stage 0 11.16 10.35 4 542676 7 63956045
Electrocardiogram QT prolonged 11.13 10.35 794 541886 78654 63877398
Renal haemorrhage 11.12 10.35 39 542641 1916 63954136
Gait deviation 11.10 10.35 7 542673 61 63955991
Actinic keratosis 11.08 10.35 78 542602 5087 63950965
Carotid endarterectomy 11.08 10.35 10 542670 156 63955896
Blood pressure diastolic abnormal 11.08 10.35 57 542623 11860 63944192
Leukaemia recurrent 11.04 10.35 4 542676 2590 63953462
Idiopathic intracranial hypertension 11.03 10.35 4 542676 2589 63953463
Bladder cancer 11.03 10.35 141 542539 10833 63945219
Ventricular arrhythmia 11.03 10.35 103 542577 7312 63948740
Ear pain 11.02 10.35 147 542533 24989 63931063
Drug eruption 11.01 10.35 226 542454 35910 63920142
Renal function test abnormal 10.99 10.35 64 542616 3910 63952142
Coronary artery embolism 10.97 10.35 13 542667 283 63955769
Mania 10.97 10.35 86 542594 16200 63939852
Compartment syndrome 10.96 10.35 67 542613 4165 63951887
Lipid metabolism disorder 10.94 10.35 13 542667 284 63955768
Essential tremor 10.93 10.35 30 542650 1289 63954763
Abnormal behaviour 10.93 10.35 208 542472 33414 63922638
Systemic mycosis 10.92 10.35 3 542677 2320 63953732
Hyponatraemic seizure 10.92 10.35 17 542663 484 63955568
Product prescribing issue 10.91 10.35 42 542638 2159 63953893
Joint laxity 10.86 10.35 3 542677 2311 63953741
Renal neoplasm 10.86 10.35 35 542645 1646 63954406
Overlap syndrome 10.84 10.35 21 542659 715 63955337
Renovascular hypertension 10.83 10.35 6 542674 40 63956012
Biopsy colon abnormal 10.79 10.35 8 542672 93 63955959
Jaundice cholestatic 10.76 10.35 116 542564 8554 63947498
Anal polyp 10.74 10.35 7 542673 65 63955987
Ligament sprain 10.72 10.35 139 542541 10713 63945339
Foot deformity 10.72 10.35 88 542592 16416 63939636
Osteonecrosis of jaw 10.72 10.35 254 542426 39571 63916481
Hyperinsulinaemic hypoglycaemia 10.71 10.35 9 542671 127 63955925
Carotid bruit 10.69 10.35 20 542660 663 63955389
Diaphragm muscle weakness 10.68 10.35 10 542670 164 63955888
Infusion site pain 10.67 10.35 48 542632 10349 63945703
Encephalitis 10.66 10.35 62 542618 12509 63943543
Pseudohyponatraemia 10.65 10.35 9 542671 128 63955924
Antimitochondrial antibody positive 10.65 10.35 8 542672 95 63955957
Circulatory collapse 10.65 10.35 365 542315 33367 63922685
Prostatic disorder 10.64 10.35 35 542645 1664 63954388
Transient global amnesia 10.59 10.35 20 542660 668 63955384
Bronchial secretion retention 10.58 10.35 4 542676 2523 63953529
Optic discs blurred 10.56 10.35 7 542673 67 63955985
Amputation 10.56 10.35 18 542662 554 63955498
Peripheral paralysis 10.54 10.35 9 542671 130 63955922
IIIrd nerve paresis 10.53 10.35 10 542670 167 63955885
Rebound tachycardia 10.51 10.35 4 542676 9 63956043
Paresis 10.50 10.35 58 542622 3474 63952578
Embedded device 10.49 10.35 5 542675 2747 63953305
Eye haemorrhage 10.44 10.35 112 542568 8248 63947804
Blue toe syndrome 10.42 10.35 18 542662 560 63955492
Hyperaesthesia 10.42 10.35 46 542634 9968 63946084
Delusion 10.40 10.35 99 542581 17915 63938137
Cytomegalovirus test positive 10.40 10.35 17 542663 5127 63950925
Drop attacks 10.39 10.35 25 542655 990 63955062
Vitreous detachment 10.39 10.35 38 542642 1906 63954146
Hypertensive angiopathy 10.38 10.35 8 542672 99 63955953
Interstitial granulomatous dermatitis 10.37 10.35 11 542669 211 63955841
Penile swelling 10.35 10.35 18 542662 563 63955489

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX15 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Slow Progression of Coronary Artery Disease indication
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Prevention of Transient Ischemic Attacks off-label use
Alcoholism contraindication 7200002
Hypothyroidism contraindication 40930008 DOID:1459
Low blood pressure contraindication 45007003
Hepatic failure contraindication 59927004
Chronic idiopathic constipation contraindication 82934008
Kidney disease contraindication 90708001 DOID:557
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Severe Aortic Valve Stenosis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic
pKa2 11.82 acidic
pKa3 13.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 8 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.29 CHEMBL
Histone deacetylase 2 Enzyme IC50 4.65 CHEMBL
Histone deacetylase 1 Enzyme IC50 4.93 CHEMBL
Histone deacetylase 6 Enzyme IC50 4.84 CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.42 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 4.49 CHEMBL

External reference:

IDSource
4024041 VUID
N0000022046 NUI
D00887 KEGG_DRUG
134523-03-8 SECONDARY_CAS_RN
344423-98-9 SECONDARY_CAS_RN
1297766 RXNORM
C0286651 UMLSCUI
CHEBI:39548 CHEBI
117 PDB_CHEM_ID
CHEMBL1487 ChEMBL_ID
CHEMBL393220 ChEMBL_ID
CHEMBL1790017 ChEMBL_ID
D000069059 MESH_DESCRIPTOR_UI
DB01076 DRUGBANK_ID
2949 IUPHAR_LIGAND_ID
7259 INN_ID
A0JWA85V8F UNII
60823 PUBCHEM_CID
186242 MMSL
34584 MMSL
4226 MMSL
d04105 MMSL
006321 NDDF
006322 NDDF
4020999 VANDF
4024041 VANDF
108600003 SNOMEDCT_US
108601004 SNOMEDCT_US
373444002 SNOMEDCT_US
725658002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2960 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2970 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2980 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6180 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6323 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6565 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6747 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7232 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7476 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7654 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7810 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0155 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0156 TABLET, FILM COATED 20 mg ORAL NDA 29 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0157 TABLET, FILM COATED 40 mg ORAL NDA 29 sections