atorvastatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 257 134523-00-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CI-981
  • CI981
  • atorvastatin calcium hydrate
  • atorvastatin calcium anhydrous
  • atorvastatin
  • atorvastatin acid
  • cardyl
  • atorvastatin calcium
  • atorvastatin calcium trihydrate
A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.
  • Molecular weight: 558.65
  • Formula: C33H35FN2O5
  • CLOGP: 4.46
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 4
  • TPSA: 111.79
  • ALOGS: -5.95
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.05 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.02 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 0.12 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Dec. 17, 1996 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1385.36 9.79 2852 378689 143677 62963804
Maternal exposure during pregnancy 1078.99 9.79 60 381481 220002 62887479
Pemphigus 1039.42 9.79 12 381529 183714 62923767
Rhabdomyolysis 964.73 9.79 1254 380287 42697 63064784
Immune-mediated myositis 884.26 9.79 325 381216 1018 63106463
Glossodynia 826.14 9.79 66 381475 178810 62928671
Systemic lupus erythematosus 818.87 9.79 136 381405 208782 62898699
Hand deformity 818.61 9.79 32 381509 159425 62948056
Contraindicated product administered 704.53 9.79 216 381325 217432 62890049
Drug ineffective 690.84 9.79 3591 377950 1041174 62066307
Anti-cyclic citrullinated peptide antibody positive 674.37 9.79 4 381537 116208 62991273
Acute kidney injury 665.82 9.79 3238 378303 260177 62847304
Exposure during pregnancy 646.92 9.79 85 381456 155462 62952019
Synovitis 614.87 9.79 180 381361 186738 62920743
Wound 542.87 9.79 154 381387 163109 62944372
Pericarditis 523.56 9.79 82 381459 131497 62975984
Treatment failure 513.60 9.79 278 381263 198765 62908716
Cerebrovascular accident 510.03 9.79 1618 379923 106406 63001075
Therapeutic product effect decreased 489.49 9.79 276 381265 192911 62914570
Myopathy 482.34 9.79 455 381086 10736 63096745
Rheumatoid factor positive 479.48 9.79 5 381536 84401 63023080
Myocardial infarction 462.24 9.79 1486 380055 98407 63009074
Infusion related reaction 457.76 9.79 480 381061 245041 62862440
Duodenal ulcer perforation 456.12 9.79 15 381526 87194 63020287
Arthropathy 420.00 9.79 475 381066 234317 62873164
Blood creatine phosphokinase increased 414.80 9.79 694 380847 29736 63077745
Drug intolerance 410.36 9.79 769 380772 307892 62799589
Off label use 405.50 9.79 2388 379153 672074 62435407
Discomfort 400.27 9.79 256 381285 167118 62940363
Swelling 388.57 9.79 661 380880 274717 62832764
Helicobacter infection 380.20 9.79 53 381488 92732 63014749
Alopecia 371.66 9.79 934 380607 336602 62770879
Product use issue 357.68 9.79 481 381060 220039 62887442
Folliculitis 332.83 9.79 23 381518 70294 63037187
Hypersensitivity 332.23 9.79 797 380744 291888 62815593
Abdominal discomfort 329.60 9.79 919 380622 319966 62787515
Muscular weakness 305.49 9.79 1500 380041 120853 62986628
Drug interaction 283.82 9.79 2349 379192 226782 62880699
Acute myocardial infarction 280.49 9.79 606 380935 31518 63075963
Joint swelling 266.36 9.79 1040 380501 326626 62780855
Coronary artery disease 262.62 9.79 593 380948 31784 63075697
Sleep disorder due to general medical condition, insomnia type 253.31 9.79 15 381526 52202 63055279
Fall 250.59 9.79 3521 378020 388813 62718668
Irritable bowel syndrome 243.61 9.79 95 381446 82317 63025164
Rheumatoid arthritis 243.00 9.79 751 380790 253068 62854413
Necrotising myositis 239.67 9.79 99 381442 458 63107023
Impaired healing 239.41 9.79 161 381380 102381 63005100
Hypomagnesaemia 229.37 9.79 523 381018 28214 63079267
Completed suicide 225.83 9.79 328 381213 145345 62962136
Muscle injury 222.01 9.79 59 381482 65286 63042195
Hepatic enzyme increased 216.14 9.79 568 380973 201760 62905721
Pain 210.34 9.79 3161 378380 737467 62370014
Rheumatic fever 201.42 9.79 15 381526 43096 63064385
Swollen joint count increased 200.89 9.79 3 381538 36051 63071430
Muscle spasms 199.18 9.79 1612 379929 154538 62952943
Lactic acidosis 198.67 9.79 593 380948 37694 63069787
Stomatitis 198.18 9.79 330 381211 138395 62969086
Hyponatraemia 197.21 9.79 1249 380292 110651 62996830
Blood glucose increased 181.98 9.79 988 380553 82768 63024713
Hypoglycaemia 179.12 9.79 776 380765 59289 63048192
Rash 173.66 9.79 2352 379189 558519 62548962
Cholestasis 173.19 9.79 477 381064 28957 63078524
Hyperkalaemia 169.93 9.79 711 380830 53492 63053989
Drug hypersensitivity 161.74 9.79 2694 378847 307993 62799488
Infection 158.84 9.79 772 380769 228401 62879080
Toxicity to various agents 158.32 9.79 856 380685 246394 62861087
Pregnancy 158.25 9.79 18 381523 36818 63070663
Intentional product use issue 158.14 9.79 332 381209 127560 62979921
Atrial fibrillation 156.30 9.79 1218 380323 115418 62992063
Transient ischaemic attack 152.67 9.79 537 381004 37216 63070265
Hemiplegia 148.07 9.79 228 381313 9095 63098386
Polymyositis 145.91 9.79 106 381435 1710 63105771
Angina pectoris 145.89 9.79 455 381086 29623 63077858
Autoimmune hepatitis 144.93 9.79 215 381326 8295 63099186
Abortion spontaneous 143.48 9.79 52 381489 47143 63060338
Ill-defined disorder 143.17 9.79 168 381373 81587 63025894
Blister 139.64 9.79 363 381178 129451 62978030
Psoriatic arthropathy 134.14 9.79 214 381327 91306 63016175
Device expulsion 133.87 9.79 24 381517 34898 63072583
Febrile neutropenia 131.44 9.79 326 381215 118123 62989358
Cardiac failure congestive 126.44 9.79 970 380571 91463 63016018
Drug abuse 125.93 9.79 150 381391 72368 63035113
Syncope 124.65 9.79 1164 380377 116221 62991260
Neurologic neglect syndrome 123.74 9.79 114 381427 2607 63104874
Diabetic ketoacidosis 123.32 9.79 335 381206 20170 63087311
Live birth 122.39 9.79 8 381533 25622 63081859
Asthenia 120.77 9.79 3088 378453 380516 62726965
Foetal exposure during pregnancy 120.30 9.79 23 381518 31939 63075542
Carotid artery thrombosis 119.24 9.79 113 381428 2681 63104800
Chest pain 118.34 9.79 1889 379652 214070 62893411
Ischaemic stroke 114.70 9.79 300 381241 17657 63089824
Anaemia 114.46 9.79 2434 379107 290996 62816485
Low density lipoprotein increased 113.17 9.79 164 381377 6193 63101288
Hip arthroplasty 110.92 9.79 75 381466 47571 63059910
Condition aggravated 110.83 9.79 1725 379816 400492 62706989
Sinusitis 109.74 9.79 854 380687 225799 62881682
Drug-induced liver injury 108.15 9.79 504 381037 39718 63067763
Liver function test abnormal 107.76 9.79 573 380968 47608 63059873
Renal failure 107.59 9.79 1131 380410 116521 62990960
Macular degeneration 107.56 9.79 357 381184 24019 63083462
Gastrointestinal haemorrhage 107.21 9.79 845 380696 80331 63027150
Fibromyalgia 106.94 9.79 200 381341 80220 63027261
Hypertensive emergency 105.92 9.79 89 381452 1793 63105688
Myositis 103.85 9.79 194 381347 9072 63098409
Melaena 102.03 9.79 407 381134 29958 63077523
Gastrointestinal disorder 101.71 9.79 424 381117 130815 62976666
Angina unstable 100.94 9.79 165 381376 6930 63100551
Premature delivery 99.75 9.79 29 381512 30252 63077229
Coronary artery occlusion 97.49 9.79 176 381365 8015 63099466
Adjustment disorder 96.49 9.79 107 381434 3071 63104410
Rectal haemorrhage 96.28 9.79 563 380978 48467 63059014
Cardiac failure 96.15 9.79 887 380654 88255 63019226
Dysarthria 95.56 9.79 508 381033 42203 63065278
Renal impairment 95.21 9.79 879 380662 87476 63020005
Musculoskeletal stiffness 93.91 9.79 686 380855 183932 62923549
Knee arthroplasty 93.17 9.79 113 381428 54093 63053388
Drug tolerance decreased 91.35 9.79 3 381538 17470 63090011
Hepatitis cholestatic 89.90 9.79 154 381387 6724 63100757
Bradycardia 89.52 9.79 749 380792 72478 63035003
Product use in unapproved indication 89.37 9.79 669 380872 178411 62929070
C-reactive protein increased 88.53 9.79 283 381258 94424 63013057
Hepatocellular injury 88.02 9.79 362 381179 27019 63080462
Malignant neoplasm progression 86.49 9.79 232 381309 81889 63025592
Intentional overdose 86.27 9.79 199 381342 73953 63033528
Dizziness 86.07 9.79 3276 378265 426649 62680832
Mobility decreased 85.10 9.79 406 381135 120753 62986728
Premature baby 84.54 9.79 12 381529 20723 63086758
Mixed liver injury 82.61 9.79 121 381420 4614 63102867
Personality disorder 82.48 9.79 135 381406 5676 63101805
Cerebral haemorrhage 81.84 9.79 384 381157 30345 63077136
Haematochezia 81.82 9.79 577 380964 52967 63054514
Diabetes mellitus 81.57 9.79 595 380946 55215 63052266
Labelled drug-drug interaction medication error 80.67 9.79 219 381322 13180 63094301
Myocardial ischaemia 80.26 9.79 213 381328 12646 63094835
Caesarean section 79.35 9.79 6 381535 17026 63090455
Glycosylated haemoglobin increased 78.03 9.79 206 381335 12192 63095289
Nasopharyngitis 77.38 9.79 1069 380472 253188 62854293
Diabetes mellitus inadequate control 77.24 9.79 233 381308 14893 63092588
Polymyalgia rheumatica 76.71 9.79 104 381437 3687 63103794
Acute coronary syndrome 75.00 9.79 179 381362 9947 63097534
Blood pressure increased 74.38 9.79 1378 380163 160684 62946797
Therapeutic drug monitoring analysis not performed 74.17 9.79 63 381478 1289 63106192
Jaundice 73.89 9.79 360 381181 28891 63078590
Bone erosion 72.83 9.79 10 381531 17707 63089774
Coronary artery stenosis 72.52 9.79 114 381427 4630 63102851
Neutropenia 71.91 9.79 688 380853 174317 62933164
Pancreatitis acute 71.27 9.79 338 381203 26828 63080653
Hemiparesis 70.31 9.79 302 381239 22980 63084501
Dehydration 70.10 9.79 1446 380095 171908 62935573
Blood triglycerides increased 69.16 9.79 198 381343 12290 63095191
Pyrexia 67.85 9.79 2233 379308 468245 62639236
Cholestatic liver injury 67.67 9.79 81 381460 2529 63104952
Lower respiratory tract infection 66.59 9.79 493 381048 131814 62975667
Pain in extremity 66.03 9.79 2525 379016 328961 62778520
Autoimmune myositis 65.87 9.79 27 381514 122 63107359
Urinary tract discomfort 65.85 9.79 44 381497 616 63106865
Aphasia 65.48 9.79 380 381161 32620 63074861
Hepatitis acute 64.11 9.79 158 381383 8962 63098519
Intentional self-injury 63.12 9.79 38 381503 25649 63081832
Motor dysfunction 62.91 9.79 174 381367 10587 63096894
Atrioventricular block 61.92 9.79 140 381401 7507 63099974
Chronic obstructive pulmonary disease 61.76 9.79 612 380929 62074 63045407
Chronic kidney disease 61.26 9.79 475 381066 44923 63062558
Hyperglycaemia 60.97 9.79 446 381095 41421 63066060
International normalised ratio increased 60.58 9.79 482 381059 45943 63061538
Atrioventricular block complete 60.19 9.79 145 381396 8106 63099375
Chromaturia 60.17 9.79 229 381312 16488 63090993
Pemphigoid 60.08 9.79 135 381406 7209 63100272
Myelosuppression 59.75 9.79 34 381507 23669 63083812
Cardiac disorder 59.06 9.79 514 381027 50302 63057179
Haematoma 59.03 9.79 385 381156 34435 63073046
Oedema peripheral 58.42 9.79 1522 380019 187989 62919492
Suicide attempt 58.35 9.79 180 381361 60738 63046743
Sensory loss 58.33 9.79 164 381377 10074 63097407
Carotid arteriosclerosis 57.55 9.79 50 381491 1056 63106425
Dyspnoea 57.30 9.79 4664 376877 656649 62450832
Hypocalcaemia 54.59 9.79 352 381189 31361 63076120
Hepatitis 54.07 9.79 417 381124 39371 63068110
Hypokalaemia 53.80 9.79 900 380641 102904 63004577
Incorrect dosage administered 53.45 9.79 64 381477 1999 63105482
Neurotoxicity 52.87 9.79 18 381523 16972 63090509
Eating disorder 52.38 9.79 240 381301 18776 63088705
Injury 52.27 9.79 244 381297 73003 63034478
Therapeutic response decreased 51.96 9.79 192 381349 61333 63046148
Decreased appetite 51.55 9.79 1919 379622 249133 62858348
Carotid artery stenosis 51.52 9.79 103 381438 5067 63102414
Alveolar osteitis 51.52 9.79 43 381498 858 63106623
Adverse event 51.25 9.79 220 381321 67339 63040142
Weight decreased 51.24 9.79 2092 379449 274706 62832775
Breast cancer stage III 50.31 9.79 3 381538 10383 63097098
Injection site reaction 49.84 9.79 182 381359 58342 63049139
Affect lability 49.80 9.79 164 381377 10987 63096494
Grip strength decreased 49.35 9.79 37 381504 22250 63085231
Gastrointestinal toxicity 49.10 9.79 129 381412 7612 63099869
Blood alkaline phosphatase increased 49.09 9.79 433 381108 42534 63064947
Labile blood pressure 48.83 9.79 57 381484 1732 63105749
Cerebral infarction 48.62 9.79 277 381264 23616 63083865
Swollen tongue 48.56 9.79 367 381174 34433 63073048
Incorrect route of product administration 48.49 9.79 56 381485 27396 63080085
Haemorrhage intracranial 48.44 9.79 184 381357 13235 63094246
Drug resistance 48.35 9.79 40 381501 22893 63084588
Dementia 47.97 9.79 232 381309 18562 63088919
Dysuria 47.19 9.79 356 381185 33382 63074099
Eosinophilia 47.09 9.79 265 381276 22491 63084990
Premature labour 47.05 9.79 9 381532 12495 63094986
Cytomegalovirus infection 46.12 9.79 35 381506 20917 63086564
Panniculitis 45.47 9.79 7 381534 11378 63096103
Blood glucose decreased 45.36 9.79 247 381294 20705 63086776
Blood loss anaemia 45.35 9.79 138 381403 8863 63098618
Hepatic cytolysis 45.10 9.79 198 381343 15209 63092272
Red blood cell sedimentation rate abnormal 44.90 9.79 32 381509 19750 63087731
Product prescribing error 44.15 9.79 290 381251 25999 63081482
Tunnel vision 44.11 9.79 45 381496 1171 63106310
Product monitoring error 43.85 9.79 89 381452 4427 63103054
Adjustment disorder with depressed mood 43.79 9.79 5 381536 10199 63097282
Device dislocation 43.73 9.79 54 381487 25651 63081830
Joint range of motion decreased 43.67 9.79 80 381461 32348 63075133
Lichen planopilaris 43.67 9.79 15 381526 36 63107445
Subdural haematoma 43.37 9.79 186 381355 14142 63093339
Injection site erythema 43.24 9.79 307 381234 82867 63024614
High density lipoprotein decreased 43.10 9.79 59 381482 2111 63105370
Urinary tract infection 42.64 9.79 1972 379569 262712 62844769
Haematemesis 42.59 9.79 321 381220 30091 63077390
Ear congestion 41.76 9.79 66 381475 2693 63104788
Vascular stent stenosis 41.55 9.79 31 381510 522 63106959
Disease progression 41.39 9.79 505 381036 122253 62985228
Infective pulmonary exacerbation of cystic fibrosis 41.38 9.79 3 381538 8814 63098667
Pre-eclampsia 40.41 9.79 4 381537 9129 63098352
Leukopenia 40.32 9.79 285 381256 77005 63030476
Euglycaemic diabetic ketoacidosis 40.03 9.79 76 381465 3598 63103883
Arteriosclerosis 39.67 9.79 142 381399 9924 63097557
Adverse drug reaction 39.63 9.79 298 381243 79416 63028065
Liver injury 39.50 9.79 208 381333 60312 63047169
Diabetic metabolic decompensation 39.39 9.79 50 381491 1660 63105821
Blood cholesterol abnormal 39.20 9.79 63 381478 2608 63104873
Large intestine polyp 39.18 9.79 123 381418 8034 63099447
Injection site swelling 39.17 9.79 150 381391 47422 63060059
Mitral valve incompetence 39.11 9.79 226 381315 19368 63088113
Inappropriate antidiuretic hormone secretion 38.84 9.79 190 381351 15272 63092209
Rheumatoid nodule 38.61 9.79 28 381513 17127 63090354
Muscle atrophy 38.45 9.79 111 381430 6922 63100559
Muscle necrosis 38.44 9.79 32 381509 636 63106845
Rectal polyp 38.11 9.79 42 381499 1197 63106284
Anuria 38.04 9.79 163 381378 12388 63095093
Mucosal inflammation 37.98 9.79 149 381392 46779 63060702
Hepatitis toxic 37.57 9.79 69 381472 3184 63104297
Gait disturbance 37.52 9.79 1400 380141 181778 62925703
Arterial occlusive disease 37.50 9.79 99 381442 5859 63101622
Gamma-glutamyltransferase increased 37.37 9.79 340 381201 33691 63073790
Red blood cell sedimentation rate increased 37.30 9.79 137 381404 43845 63063636
Respiratory depression 37.04 9.79 18 381523 13697 63093784
Upper gastrointestinal haemorrhage 36.69 9.79 216 381325 18636 63088845
Intestinal haemorrhage 36.39 9.79 75 381466 3772 63103709
Flatulence 36.24 9.79 343 381198 34359 63073122
Body height decreased 36.22 9.79 138 381403 9940 63097541
Myopathy toxic 36.05 9.79 28 381513 502 63106979
Type 2 diabetes mellitus 35.56 9.79 231 381310 63637 63043844
Pulmonary toxicity 35.25 9.79 131 381410 9324 63098157
Abortion induced 35.25 9.79 9 381532 10233 63097248
Coordination abnormal 35.14 9.79 170 381371 13603 63093878
Product substitution issue 34.92 9.79 189 381352 15807 63091674
Prescribed overdose 34.82 9.79 98 381443 34055 63073426
Hyperlipidaemia 34.77 9.79 219 381322 19352 63088129
X-ray abnormal 34.74 9.79 4 381537 8106 63099375
Hypoacusis 34.43 9.79 256 381285 23895 63083586
Low density lipoprotein abnormal 34.35 9.79 20 381521 216 63107265
Blood iron decreased 34.23 9.79 177 381364 14544 63092937
Accidental exposure to product 33.96 9.79 71 381470 27334 63080147
Angioedema 33.96 9.79 439 381102 47526 63059955
Dysphagia 33.85 9.79 733 380808 87852 63019629
Coma 33.74 9.79 237 381304 64127 63043354
Aortic stenosis 33.22 9.79 85 381456 4935 63102546
Pollakiuria 33.20 9.79 284 381257 27653 63079828
Ischaemic cardiomyopathy 33.09 9.79 56 381485 2421 63105060
Tenosynovitis 33.07 9.79 21 381520 13774 63093707
Peripheral arterial occlusive disease 33.01 9.79 76 381465 4125 63103356
Amnesia 32.97 9.79 493 381048 55092 63052389
Dislocation of vertebra 32.95 9.79 6 381535 8629 63098852
Muscle disorder 32.74 9.79 84 381457 4885 63102596
Cerebral haematoma 32.74 9.79 70 381471 3613 63103868
Inflammation 32.68 9.79 326 381215 81947 63025534
Loss of personal independence in daily activities 32.50 9.79 401 381140 96889 63010592
Arthralgia 32.48 9.79 2965 378576 566745 62540736
Thyroid disorder 32.32 9.79 178 381363 14984 63092497
Urinary tract obstruction 32.29 9.79 52 381489 2156 63105325
Myoglobin blood increased 32.23 9.79 41 381500 1364 63106117
Weight increased 32.21 9.79 1261 380280 259531 62847950
Hepatic function abnormal 32.03 9.79 353 381188 36789 63070692
Blood creatine phosphokinase MB increased 31.96 9.79 38 381503 1178 63106303
Animal scratch 31.93 9.79 41 381500 1377 63106104
Head injury 31.77 9.79 277 381264 27119 63080362
Lip swelling 31.43 9.79 305 381236 30758 63076723
Haematuria 30.85 9.79 289 381252 28868 63078613
Glomerular filtration rate decreased 30.83 9.79 161 381380 13280 63094201
Enthesopathy 30.76 9.79 7 381534 8607 63098874
Peripheral artery stenosis 30.66 9.79 27 381514 581 63106900
Malaise 30.53 9.79 2899 378642 413055 62694426
Subacute cutaneous lupus erythematosus 30.45 9.79 56 381485 2587 63104894
Myocardial necrosis marker increased 30.33 9.79 46 381495 1810 63105671
Diabetic retinopathy 30.28 9.79 52 381489 2275 63105206
Breast cancer stage II 29.45 9.79 8 381533 8728 63098753
Electrolyte imbalance 29.30 9.79 214 381327 19862 63087619
Bladder pain 29.28 9.79 51 381490 2257 63105224
Pancytopenia 29.27 9.79 408 381133 96525 63010956
Presyncope 29.20 9.79 275 381266 27510 63079971
Hypotension 29.13 9.79 1956 379585 270648 62836833
Neutrophil count decreased 28.93 9.79 209 381332 56197 63051284
Hypovolaemia 28.87 9.79 134 381407 10539 63096942
Pulmonary renal syndrome 28.76 9.79 23 381518 431 63107050
Faeces discoloured 28.58 9.79 200 381341 18309 63089172
Duodenal ulcer 28.53 9.79 107 381434 7649 63099832
Uterine perforation 28.46 9.79 4 381537 6959 63100522
Polyuria 28.29 9.79 114 381427 8428 63099053
Embolic stroke 28.23 9.79 67 381474 3709 63103772
Hepatic steatosis 27.90 9.79 280 381261 28489 63078992
Joint injury 27.81 9.79 286 381255 29286 63078195
Oligohydramnios 27.62 9.79 3 381538 6363 63101118
Cell death 27.35 9.79 53 381488 2548 63104933
Immunodeficiency 27.24 9.79 50 381491 20204 63087277
Dysgeusia 27.20 9.79 413 381128 46297 63061184
Blood creatinine increased 27.18 9.79 706 380835 87138 63020343
Blood urea increased 27.18 9.79 260 381281 26119 63081362
Joint destruction 26.99 9.79 3 381538 6249 63101232
Creatinine renal clearance decreased 26.97 9.79 35 381506 16273 63091208
Maternal exposure timing unspecified 26.88 9.79 5 381536 7082 63100399
Amenorrhoea 26.79 9.79 13 381528 9901 63097580
Aldolase increased 26.74 9.79 15 381526 150 63107331
Hepatic ischaemia 26.72 9.79 26 381515 638 63106843
Haemorrhagic transformation stroke 26.71 9.79 35 381506 1200 63106281
Therapeutic product effect incomplete 26.55 9.79 561 380980 124495 62982986
Food allergy 26.46 9.79 18 381523 11383 63096098
Angiopathy 26.38 9.79 74 381467 4539 63102942
Dyspnoea exertional 26.34 9.79 509 381032 59793 63047688
Cardiotoxicity 26.15 9.79 9 381532 8429 63099052
Electrocardiogram abnormal 26.14 9.79 117 381424 9062 63098419
Subarachnoid haemorrhage 26.11 9.79 161 381380 14122 63093359
Mouth swelling 26.10 9.79 75 381466 4665 63102816
Palpitations 26.08 9.79 874 380667 111896 62995585
Vertigo 25.99 9.79 505 381036 59382 63048099
Eructation 25.86 9.79 109 381432 8224 63099257
Rales 25.70 9.79 147 381394 12550 63094931
Renal disorder 25.57 9.79 307 381234 32667 63074814
Spur cell anaemia 25.35 9.79 10 381531 40 63107441
Injection site pain 25.35 9.79 590 380951 129210 62978271
Sinus disorder 25.29 9.79 242 381299 24311 63083170
Hypertensive crisis 25.29 9.79 168 381373 15118 63092363
Stent placement 25.29 9.79 64 381477 3691 63103790
Acute myeloid leukaemia 25.20 9.79 40 381501 17107 63090374
Graft versus host disease 25.17 9.79 5 381536 6758 63100723
Traumatic coma 25.03 9.79 11 381530 61 63107420
Sedation 24.98 9.79 134 381407 38675 63068806
Blood parathyroid hormone decreased 24.74 9.79 14 381527 9777 63097704
Onychomadesis 24.72 9.79 3 381538 5837 63101644
Psoriasis 24.66 9.79 691 380850 86266 63021215
Cardiac failure acute 24.62 9.79 118 381423 9405 63098076
Skin haemorrhage 24.61 9.79 123 381418 9971 63097510
Disorientation 24.61 9.79 353 381188 39099 63068382
Blood pressure systolic increased 24.56 9.79 411 381130 46986 63060495
Atrial flutter 24.49 9.79 120 381421 9652 63097829
Blood sodium decreased 24.48 9.79 238 381303 24014 63083467
Epistaxis 24.43 9.79 591 380950 72134 63035347
Haemophagocytic lymphohistiocytosis 24.37 9.79 17 381524 10610 63096871
Post viral fatigue syndrome 24.33 9.79 18 381523 299 63107182
Respiratory arrest 24.33 9.79 107 381434 32538 63074943
Vascular device infection 24.09 9.79 7 381534 7305 63100176
Back pain 24.05 9.79 1871 379670 262274 62845207
Metastases to bone 23.97 9.79 57 381484 20962 63086519
Musculoskeletal chest pain 23.84 9.79 212 381329 20871 63086610
Carotid artery occlusion 23.68 9.79 72 381469 4622 63102859
Migraine 23.61 9.79 458 381083 102888 63004593
Gastric ulcer 23.34 9.79 234 381307 23803 63083678
Foetal death 23.33 9.79 19 381522 10961 63096520
Wound complication 23.32 9.79 62 381479 3685 63103796
Fatigue 23.31 9.79 4849 376692 883179 62224302
Sickle cell anaemia with crisis 23.28 9.79 4 381537 5999 63101482
Cerebral ischaemia 23.26 9.79 91 381450 6637 63100844
Cystostomy 23.15 9.79 11 381530 75 63107406
Hypertensive cardiomyopathy 23.13 9.79 15 381526 199 63107282
Antimitochondrial antibody positive 23.03 9.79 11 381530 76 63107405
Spinal epidural haematoma 22.93 9.79 31 381510 1096 63106385
Retinal artery occlusion 22.92 9.79 38 381503 1615 63105866
Dermatomyositis 22.90 9.79 52 381489 2796 63104685
Ketoacidosis 22.88 9.79 68 381473 4310 63103171
Chest discomfort 22.87 9.79 842 380699 109127 62998354
Diarrhoea 22.84 9.79 4747 376794 710619 62396862
Coronary artery thrombosis 22.67 9.79 31 381510 1108 63106373
Confusional state 22.63 9.79 1681 379860 234699 62872782
Electrocardiogram QT prolonged 22.55 9.79 492 381049 59038 63048443
Sinus bradycardia 22.33 9.79 157 381384 14394 63093087
Facet joint syndrome 22.27 9.79 24 381517 12114 63095367
Ear infection 21.89 9.79 137 381404 38076 63069405
Complication of device insertion 21.88 9.79 9 381532 7555 63099926
Balance disorder 21.79 9.79 663 380878 83759 63023722
Unintentional medical device removal 21.78 9.79 5 381536 6110 63101371
Haematotoxicity 21.50 9.79 15 381526 9361 63098120
Maternal drugs affecting foetus 21.45 9.79 3 381538 5239 63102242
Arterial stenosis 21.42 9.79 22 381519 577 63106904
Wound infection 21.41 9.79 62 381479 21348 63086133
Pancreatitis 21.40 9.79 414 381127 48641 63058840
Blood creatine phosphokinase abnormal 21.35 9.79 15 381526 229 63107252
Pathogen resistance 21.31 9.79 6 381535 6392 63101089
Multi-organ disorder 21.29 9.79 35 381506 1477 63106004
Hypovolaemic shock 21.24 9.79 84 381457 6157 63101324
Fibromatosis colli of infancy 21.24 9.79 7 381534 14 63107467
Acquired plagiocephaly 21.24 9.79 7 381534 14 63107467
Ankylosing spondylitis 21.19 9.79 19 381522 10455 63097026
Movement disorder 21.09 9.79 211 381330 21450 63086031
Hepatorenal syndrome 21.09 9.79 40 381501 1892 63105589
Device related infection 21.08 9.79 71 381470 23321 63084160
Dysstasia 21.01 9.79 207 381334 20959 63086522
Tubulointerstitial nephritis 20.92 9.79 197 381344 19706 63087775
Device adhesion issue 20.90 9.79 3 381538 5138 63102343
Acidosis 20.77 9.79 127 381414 11106 63096375
Febrile bone marrow aplasia 20.74 9.79 9 381532 7316 63100165
Myoglobinuria 20.73 9.79 16 381525 284 63107197
Hyperlactacidaemia 20.71 9.79 50 381491 2799 63104682
Urine output decreased 20.68 9.79 128 381413 11242 63096239
Dermatitis atopic 20.62 9.79 114 381427 9610 63097871
Lecithin-cholesterol acyltransferase deficiency 20.60 9.79 6 381535 6 63107475
Cervix neoplasm 20.53 9.79 14 381527 203 63107278
Ocular myasthenia 20.50 9.79 12 381529 131 63107350
Alanine aminotransferase increased 20.49 9.79 790 380751 102980 63004501
Alanine aminotransferase 20.48 9.79 10 381531 73 63107408
Muscle relaxant therapy 20.47 9.79 13 381528 166 63107315
Interstitial lung disease 20.46 9.79 502 381039 61406 63046075
Deformity 20.45 9.79 24 381517 11660 63095821
Nasal obstruction 20.35 9.79 37 381504 1694 63105787
Systemic infection 20.33 9.79 68 381473 4592 63102889
Suicidal ideation 20.20 9.79 259 381282 62162 63045319
Urticaria 20.17 9.79 803 380738 164999 62942482
Transplant rejection 20.13 9.79 21 381520 10759 63096722
Paranasal sinus discomfort 20.12 9.79 65 381476 4311 63103170
Tongue oedema 20.08 9.79 67 381474 4519 63102962
Incision site haemorrhage 20.05 9.79 21 381520 564 63106917
Coronary artery bypass 19.89 9.79 44 381497 2325 63105156
C-reactive protein abnormal 19.86 9.79 179 381362 45917 63061564
Aspergillus infection 19.84 9.79 12 381529 8081 63099400
Low birth weight baby 19.80 9.79 9 381532 7120 63100361
Chloropsia 19.72 9.79 8 381533 35 63107446
Troponin increased 19.72 9.79 116 381425 10005 63097476
Arteriosclerosis coronary artery 19.69 9.79 101 381440 8272 63099209
Pulmonary oedema 19.68 9.79 450 381091 54423 63053058
Epstein-Barr virus infection 19.65 9.79 12 381529 8038 63099443
Hypophagia 19.62 9.79 280 381261 30979 63076502
Waist circumference increased 19.60 9.79 26 381515 902 63106579
Diabetic nephropathy 19.59 9.79 33 381508 1421 63106060
Nausea 19.52 9.79 5586 375955 848885 62258596
Cardiac murmur 19.48 9.79 152 381389 14400 63093081
Arteriovenous fistula occlusion 19.45 9.79 17 381524 362 63107119
Diverticulum intestinal 19.44 9.79 86 381455 6627 63100854
Mydriasis 19.42 9.79 26 381515 11930 63095551
Diverticulum 19.36 9.79 131 381410 11860 63095621
Cataract 19.27 9.79 464 381077 56589 63050892
Coronary artery restenosis 19.26 9.79 17 381524 367 63107114
Poisoning 19.16 9.79 33 381508 13667 63093814
Metastases to liver 19.16 9.79 75 381466 23564 63083917
Skin necrosis 19.15 9.79 34 381507 13916 63093565
Albuminuria 19.11 9.79 14 381527 229 63107252
Hypocapnia 18.99 9.79 17 381524 374 63107107
Abnormal dreams 18.88 9.79 118 381423 10398 63097083
Heavy menstrual bleeding 18.86 9.79 50 381491 17723 63089758
Choluria 18.81 9.79 13 381528 193 63107288
Coeliac disease 18.67 9.79 30 381511 12767 63094714
Device difficult to use 18.66 9.79 30 381511 12766 63094715
Hallucination, gustatory 18.63 9.79 9 381532 64 63107417
Tuberculosis 18.60 9.79 24 381517 11187 63096294
Ventricular hypertrophy 18.56 9.79 54 381487 3382 63104099
Lip dry 18.41 9.79 41 381500 15429 63092052
Left atrial enlargement 18.24 9.79 15 381526 293 63107188
Acne 18.19 9.79 75 381466 23218 63084263
Ageusia 18.16 9.79 143 381398 13585 63093896
Vascular stent occlusion 18.11 9.79 8 381533 45 63107436
Drug ineffective for unapproved indication 18.06 9.79 125 381416 33938 63073543
Intra-abdominal haematoma 18.03 9.79 36 381505 1769 63105712
Aspartate aminotransferase increased 17.99 9.79 688 380853 89589 63017892
Hallucination 17.97 9.79 444 381097 54373 63053108
Dyslipidaemia 17.97 9.79 90 381451 7303 63100178
Periorbital haematoma 17.95 9.79 23 381518 771 63106710
Metastases to central nervous system 17.94 9.79 32 381509 13073 63094408
Feeling cold 17.91 9.79 221 381320 23667 63083814
Bronchopulmonary aspergillosis allergic 17.91 9.79 41 381500 2217 63105264
Cough 17.83 9.79 2015 379526 290728 62816753
Muscular dystrophy 17.82 9.79 8 381533 47 63107434
Electrocardiogram Q wave abnormal 17.78 9.79 12 381529 171 63107310
Blood pressure inadequately controlled 17.75 9.79 68 381473 4910 63102571
Prolonged expiration 17.68 9.79 27 381514 1069 63106412
Multiple sclerosis relapse 17.66 9.79 196 381345 48282 63059199
Eye haemorrhage 17.62 9.79 99 381442 8397 63099084
Hypomania 17.57 9.79 8 381533 6322 63101159
Intermittent claudication 17.57 9.79 36 381505 1803 63105678
Peripheral nerve palsy 17.55 9.79 7 381534 29 63107452
Diabetic ketosis 17.52 9.79 14 381527 262 63107219
Neurosensory hypoacusis 17.52 9.79 13 381528 217 63107264
Therapy partial responder 17.50 9.79 23 381518 10635 63096846
Diabetic neuropathy 17.43 9.79 58 381483 3906 63103575
Subchondral insufficiency fracture 17.42 9.79 8 381533 50 63107431
Coronary artery surgery 17.42 9.79 8 381533 50 63107431
Calcium deficiency 17.35 9.79 27 381514 1087 63106394
Bone marrow failure 17.30 9.79 104 381437 29186 63078295
Large intestinal haemorrhage 17.28 9.79 30 381511 1324 63106157
Wound secretion 17.26 9.79 64 381477 4550 63102931
Breast cancer stage I 17.19 9.79 10 381531 6879 63100602
Blood potassium increased 17.18 9.79 177 381364 18132 63089349
Feeling abnormal 17.14 9.79 1072 380469 147320 62960161
Mammogram abnormal 17.13 9.79 22 381519 739 63106742
Device issue 17.09 9.79 79 381462 23702 63083779
International normalised ratio abnormal 16.97 9.79 51 381490 3253 63104228
Muscle discomfort 16.92 9.79 12 381529 186 63107295
Blood electrolytes abnormal 16.92 9.79 26 381515 1035 63106446
Urinary retention 16.91 9.79 266 381275 30035 63077446
Facial paralysis 16.82 9.79 143 381398 13898 63093583
Overdose 16.79 9.79 545 380996 114533 62992948
Microcytic anaemia 16.74 9.79 52 381489 3377 63104104
Abnormal loss of weight 16.69 9.79 74 381467 5708 63101773
Carotid artery disease 16.61 9.79 33 381508 1616 63105865
Polyarthritis 16.55 9.79 22 381519 10124 63097357
Cholangiolitis 16.48 9.79 4 381537 0 63107481
Psychotic disorder 16.43 9.79 89 381452 25623 63081858
Macular oedema 16.41 9.79 56 381485 3821 63103660
Aplastic anaemia 16.38 9.79 20 381521 9549 63097932
Menstruation irregular 16.33 9.79 11 381530 6993 63100488
Disability 16.32 9.79 56 381485 18291 63089190
Chest wall haematoma 16.29 9.79 12 381529 198 63107283
Troponin T increased 16.29 9.79 28 381513 1226 63106255
Transaminases increased 16.25 9.79 272 381269 31095 63076386
Tumour lysis syndrome 16.24 9.79 18 381523 8972 63098509
Parkinsonism 16.24 9.79 113 381428 10326 63097155
Glucose urine present 16.23 9.79 21 381520 711 63106770
Ligament sprain 16.21 9.79 132 381409 12668 63094813
Lipoprotein (a) increased 16.20 9.79 7 381534 37 63107444
Stevens-Johnson syndrome 16.14 9.79 86 381455 24864 63082617
High density lipoprotein abnormal 16.14 9.79 10 381531 122 63107359
Patent ductus arteriosus 16.12 9.79 3 381538 4247 63103234
Hypervolaemia 16.07 9.79 250 381291 28163 63079318
Cardiac discomfort 16.06 9.79 24 381517 932 63106549
Prothrombin consumption time prolonged 16.05 9.79 7 381534 38 63107443
Menstrual disorder 15.90 9.79 6 381535 5307 63102174
Sinus node dysfunction 15.90 9.79 63 381478 4622 63102859
Paresis 15.88 9.79 42 381499 2488 63104993
Eosinophilic fasciitis 15.87 9.79 11 381530 164 63107317
Cerebral microangiopathy 15.80 9.79 13 381528 254 63107227
N-terminal prohormone brain natriuretic peptide increased 15.79 9.79 38 381503 2123 63105358
Renal injury 15.77 9.79 104 381437 9335 63098146
Progressive multifocal leukoencephalopathy 15.74 9.79 34 381507 12937 63094544
Lower gastrointestinal haemorrhage 15.74 9.79 91 381450 7799 63099682
Arrhythmia 15.67 9.79 319 381222 37821 63069660
Paradoxical drug reaction 15.60 9.79 3 381538 4149 63103332
Calculus urinary 15.54 9.79 29 381512 1355 63106126
Muscle fatigue 15.53 9.79 42 381499 2522 63104959
Cardiac failure chronic 15.47 9.79 60 381481 4358 63103123
Sebaceous gland infection 15.43 9.79 11 381530 172 63107309
Injection site pruritus 15.42 9.79 185 381356 44931 63062550
Blood lactic acid 15.39 9.79 9 381532 98 63107383
Heart sounds 15.32 9.79 24 381517 972 63106509
Vascular graft occlusion 15.27 9.79 12 381529 219 63107262
Injection site warmth 15.19 9.79 44 381497 15151 63092330
Haemoglobin decreased 15.18 9.79 1042 380499 144443 62963038
Cardiac operation 15.17 9.79 49 381492 3249 63104232
Depressed mood 15.16 9.79 332 381209 39859 63067622
Flank pain 15.10 9.79 158 381383 16252 63091229
Pallor 15.09 9.79 263 381278 30305 63077176
Gouty arthritis 15.01 9.79 18 381523 563 63106918
Oesophageal obstruction 14.99 9.79 18 381523 564 63106917
Colitis ischaemic 14.98 9.79 113 381428 10595 63096886
Staphylococcal infection 14.95 9.79 167 381374 41089 63066392
Basal ganglia haemorrhage 14.87 9.79 19 381522 635 63106846
Blood cholesterol decreased 14.87 9.79 23 381518 921 63106560
Tobacco abuse 14.82 9.79 20 381521 706 63106775
Poisoning deliberate 14.82 9.79 28 381513 11190 63096291
Bacteraemia 14.73 9.79 54 381487 17294 63090187
Blue toe syndrome 14.65 9.79 15 381526 392 63107089
Cytokine release syndrome 14.64 9.79 41 381500 14273 63093208
Blood creatinine abnormal 14.60 9.79 46 381495 3010 63104471
Seronegative arthritis 14.58 9.79 3 381538 3956 63103525
Endocrine ophthalmopathy 14.48 9.79 19 381522 652 63106829
Percutaneous coronary intervention 14.48 9.79 12 381529 237 63107244
Haemorrhagic cyst 14.46 9.79 11 381530 191 63107290
Type V hyperlipidaemia 14.40 9.79 17 381524 523 63106958
Orthostatic hypotension 14.38 9.79 301 381240 35859 63071622
Muscle enzyme increased 14.38 9.79 10 381531 150 63107331
Atrial tachycardia 14.38 9.79 57 381484 4183 63103298
Ecchymosis 14.37 9.79 115 381426 10979 63096502
Hypertransaminasaemia 14.36 9.79 78 381463 6531 63100950
Acute respiratory failure 14.36 9.79 289 381252 34196 63073285
Renal tubular necrosis 14.24 9.79 121 381420 11757 63095724
Wrong patient received product 14.22 9.79 37 381504 2170 63105311
Exercise tolerance decreased 14.13 9.79 68 381473 5429 63102052
Bladder sphincter atony 14.10 9.79 10 381531 155 63107326
Saliva altered 14.08 9.79 14 381527 353 63107128
Candida infection 14.08 9.79 106 381435 28245 63079236
Neoplasm malignant 14.06 9.79 255 381286 29606 63077875
Unintended pregnancy 14.02 9.79 10 381531 6169 63101312
Vascular graft 14.00 9.79 21 381520 818 63106663
Palmar-plantar erythrodysaesthesia syndrome 13.98 9.79 81 381460 22934 63084547
Torsade de pointes 13.96 9.79 132 381409 13219 63094262
Posture abnormal 13.92 9.79 38 381503 2294 63105187
Wrong dose 13.90 9.79 26 381515 1217 63106264
Hypertensive angiopathy 13.85 9.79 8 381533 85 63107396
Lacunar stroke 13.83 9.79 10 381531 160 63107321
Blood urine present 13.82 9.79 145 381396 14924 63092557
Lower limb fracture 13.79 9.79 87 381454 24134 63083347
Muscle rupture 13.78 9.79 39 381502 2404 63105077
Administration site discomfort 13.77 9.79 8 381533 86 63107395
Arterial insufficiency 13.76 9.79 11 381530 206 63107275
Contusion 13.76 9.79 749 380792 149295 62958186
Copper metabolism disorder 13.73 9.79 4 381537 4 63107477
Dopamine transporter scintigraphy abnormal 13.69 9.79 8 381533 87 63107394
Cardiac pacemaker insertion 13.61 9.79 55 381486 4071 63103410
Aortic valve replacement 13.61 9.79 20 381521 765 63106716
Immune reconstitution inflammatory syndrome 13.60 9.79 10 381531 6074 63101407
Hyponatraemic seizure 13.60 9.79 15 381526 428 63107053
Drug tolerance 13.59 9.79 13 381528 6936 63100545
Lung disorder 13.59 9.79 278 381263 61983 63045498
Gastric ulcer haemorrhage 13.56 9.79 62 381479 4846 63102635
Multiple injuries 13.55 9.79 32 381509 1766 63105715
Cardiac valve disease 13.49 9.79 56 381485 4196 63103285
Respiratory disorder 13.46 9.79 160 381381 38922 63068559
Diabetic foot 13.44 9.79 28 381513 1419 63106062
Ventricular internal diameter abnormal 13.40 9.79 6 381535 35 63107446
Change of bowel habit 13.36 9.79 36 381505 2157 63105324
Sinus pain 13.35 9.79 48 381493 3362 63104119
Memory impairment 13.32 9.79 760 380781 103498 63003983
Nail bed inflammation 13.31 9.79 14 381527 378 63107103
Cholelithiasis 13.28 9.79 352 381189 43573 63063908
Jaundice hepatocellular 13.26 9.79 6 381535 36 63107445
Prevertebral soft tissue swelling of cervical space 13.26 9.79 6 381535 36 63107445
Gait deviation 13.20 9.79 7 381534 62 63107419
Bundle branch block left 13.17 9.79 80 381461 6979 63100502
Retroperitoneal haematoma 13.15 9.79 43 381498 2870 63104611
Gastritis 13.09 9.79 305 381236 36998 63070483
Renovascular hypertension 13.08 9.79 5 381536 18 63107463
High density lipoprotein increased 13.04 9.79 21 381520 871 63106610
Ventricular septal defect 13.01 9.79 5 381536 4373 63103108
Nephrosclerosis 12.99 9.79 23 381518 1031 63106450
Post transplant lymphoproliferative disorder 12.99 9.79 7 381534 5024 63102457
Peripheral vascular disorder 12.96 9.79 71 381470 5964 63101517
Swelling face 12.94 9.79 485 381056 62990 63044491
Lethargy 12.92 9.79 434 381107 55573 63051908
Xanthelasma 12.92 9.79 7 381534 65 63107416
Genital haemorrhage 12.90 9.79 15 381526 7317 63100164
Ballismus 12.89 9.79 9 381532 136 63107345
Nightmare 12.88 9.79 174 381367 19020 63088461
Myoglobinaemia 12.87 9.79 5 381536 19 63107462
Bronchopulmonary aspergillosis 12.83 9.79 20 381521 8615 63098866
Lipids abnormal 12.79 9.79 12 381529 281 63107200
IIIrd nerve paresis 12.77 9.79 9 381532 138 63107343
Hyperglycaemic hyperosmolar nonketotic syndrome 12.74 9.79 22 381519 967 63106514
Hypokinesia 12.73 9.79 134 381407 13802 63093679
Cerebral mass effect 12.67 9.79 21 381520 892 63106589
Neuroglycopenia 12.67 9.79 15 381526 463 63107018
Muscle haemorrhage 12.66 9.79 45 381496 3134 63104347
Urinary occult blood positive 12.65 9.79 7 381534 68 63107413
Internal haemorrhage 12.64 9.79 63 381478 5102 63102379
Cardiogenic shock 12.64 9.79 164 381377 17768 63089713
Low density lipoprotein decreased 12.63 9.79 11 381530 233 63107248
Blood cholesterol increased 12.63 9.79 450 381091 93582 63013899
Joint dislocation 12.61 9.79 64 381477 18736 63088745
Blood magnesium decreased 12.58 9.79 128 381413 13070 63094411
Adenovirus infection 12.56 9.79 3 381538 3568 63103913
Diverticulum oesophageal 12.56 9.79 9 381532 142 63107339
Prescribed underdose 12.48 9.79 116 381425 29573 63077908
Biliary fibrosis 12.48 9.79 4 381537 7 63107474
Vascular stenosis 12.48 9.79 13 381528 347 63107134
Cardiomyopathy 12.47 9.79 161 381380 17423 63090058
Ascites 12.44 9.79 171 381370 40557 63066924
Product dose omission issue 12.44 9.79 1599 379942 232714 62874767
Drug specific antibody present 12.43 9.79 5 381536 4254 63103227
Transient acantholytic dermatosis 12.39 9.79 7 381534 71 63107410
Normochromic normocytic anaemia 12.39 9.79 58 381483 4578 63102903
Parkinsonian rest tremor 12.35 9.79 8 381533 106 63107375
Faeces pale 12.34 9.79 30 381511 1687 63105794
Infection susceptibility increased 12.30 9.79 3 381538 3518 63103963
Renal artery stenosis 12.30 9.79 32 381509 1877 63105604
Product administration error 12.27 9.79 196 381345 22201 63085280
Pneumocystis jirovecii pneumonia 12.26 9.79 56 381485 16858 63090623
Cardiac flutter 12.26 9.79 53 381488 4043 63103438
Hypochloraemia 12.26 9.79 33 381508 1976 63105505
Blood iron abnormal 12.25 9.79 4 381537 3872 63103609
Oral herpes 12.24 9.79 99 381442 25975 63081506
Blood immunoglobulin E increased 12.11 9.79 4 381537 3845 63103636
Throat clearing 12.10 9.79 37 381504 2382 63105099
Primary biliary cholangitis 12.08 9.79 24 381517 1175 63106306
Joint effusion 12.07 9.79 57 381484 17003 63090478
Gastroduodenal haemorrhage 11.99 9.79 7 381534 76 63107405
Lung neoplasm malignant 11.98 9.79 175 381366 19458 63088023
Shock haemorrhagic 11.97 9.79 101 381440 9794 63097687
Lung hyperinflation 11.96 9.79 25 381516 1270 63106211
End stage renal disease 11.95 9.79 75 381466 6618 63100863
Crystal urine 11.93 9.79 6 381535 47 63107434
Narrow anterior chamber angle 11.93 9.79 6 381535 47 63107434
Albumin urine present 11.92 9.79 11 381530 252 63107229
Neurofibrosarcoma 11.89 9.79 9 381532 155 63107326
Dialysis 11.87 9.79 105 381436 10322 63097159
Neoplasm progression 11.84 9.79 151 381390 36277 63071204
Eyelid retraction 11.83 9.79 6 381535 48 63107433
Muscle oedema 11.82 9.79 4 381537 9 63107472
Inclusion body myositis 11.82 9.79 4 381537 9 63107472
Seizure 11.81 9.79 664 380877 131970 62975511
Parapsoriasis 11.79 9.79 8 381533 115 63107366
Deafness 11.73 9.79 162 381379 17795 63089686
Ureteric obstruction 11.69 9.79 31 381510 1839 63105642
Haemorrhagic stroke 11.69 9.79 67 381474 5725 63101756
Stillbirth 11.67 9.79 14 381527 6736 63100745
Blood pressure decreased 11.67 9.79 490 381051 64532 63042949
Product taste abnormal 11.67 9.79 33 381508 2034 63105447
Colitis microscopic 11.66 9.79 96 381445 9243 63098238
Soft tissue disorder 11.65 9.79 6 381535 4416 63103065
Dementia Alzheimer's type 11.64 9.79 22 381519 1038 63106443
Cervicobrachial syndrome 11.64 9.79 21 381520 956 63106525
Hypergammaglobulinaemia 11.63 9.79 15 381526 506 63106975
Lipohypertrophy 11.61 9.79 17 381524 648 63106833
Peripheral coldness 11.60 9.79 118 381423 12047 63095434
Mitral valve disease 11.55 9.79 37 381504 2443 63105038
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.51 9.79 41 381500 2858 63104623
Accelerated hypertension 11.50 9.79 14 381527 445 63107036
Paraesthesia oral 11.50 9.79 171 381370 19085 63088396
Dilatation atrial 11.45 9.79 32 381509 1959 63105522
Myeloma cast nephropathy 11.39 9.79 8 381533 122 63107359
Furuncle 11.37 9.79 73 381468 6493 63100988
Acute pulmonary oedema 11.36 9.79 86 381455 8072 63099409
Bifascicular block 11.34 9.79 8 381533 123 63107358
Blood calcitonin increased 11.34 9.79 5 381536 28 63107453
Connective tissue inflammation 11.33 9.79 6 381535 53 63107428
Oesophagitis 11.32 9.79 139 381402 14869 63092612
Constipation 11.30 9.79 1530 380011 223413 62884068
Juvenile idiopathic arthritis 11.30 9.79 3 381538 3323 63104158
Cardio-respiratory arrest 11.29 9.79 274 381267 59685 63047796
Glomerular filtration rate abnormal 11.25 9.79 19 381522 820 63106661
Hypothermia 11.22 9.79 128 381413 13453 63094028
Fear of injection 11.22 9.79 16 381525 7148 63100333
Product complaint 11.16 9.79 122 381419 12687 63094794
Procedural pain 11.16 9.79 187 381354 21382 63086099
Mean cell haemoglobin increased 11.16 9.79 41 381500 2902 63104579
Lymphomatoid papulosis 11.12 9.79 8 381533 127 63107354
Cholecystitis chronic 11.11 9.79 29 381512 10332 63097149
Colorectal cancer 11.10 9.79 4 381537 3641 63103840
Dystonia 11.10 9.79 44 381497 13775 63093706
Hiatus hernia 11.09 9.79 187 381354 21407 63086074
Intracranial haematoma 11.09 9.79 13 381528 397 63107084
Blood calcium increased 11.08 9.79 95 381446 9255 63098226
Lipoma 11.08 9.79 36 381505 2395 63105086
Acute left ventricular failure 11.08 9.79 22 381519 1077 63106404
Exercise tolerance increased 11.05 9.79 5 381536 30 63107451
Iron deficiency anaemia 11.03 9.79 175 381366 19794 63087687
Cerebral artery stenosis 11 9.79 14 381527 466 63107015
Speech disorder 11.00 9.79 321 381220 40308 63067173
Ichthyosis 10.96 9.79 6 381535 57 63107424
Loss of consciousness 10.95 9.79 838 380703 117283 62990198
Tenderness 10.94 9.79 85 381456 22493 63084988
Urine abnormality 10.93 9.79 76 381465 6943 63100538
Diverticulum intestinal haemorrhagic 10.93 9.79 27 381514 1534 63105947
Eyelid disorder 10.91 9.79 30 381511 1819 63105662
Liver disorder 10.90 9.79 410 381131 53277 63054204
Vaginal haemorrhage 10.88 9.79 109 381432 27378 63080103
Ovarian cyst 10.86 9.79 54 381487 15891 63091590
Flushing 10.86 9.79 356 381185 74731 63032750
Vascular purpura 10.81 9.79 26 381515 1452 63106029
Noninfectious peritonitis 10.76 9.79 8 381533 134 63107347
Nail disorder 10.74 9.79 41 381500 12974 63094507
Cerebrovascular arteriovenous malformation 10.72 9.79 7 381534 94 63107387
Hyperprolactinaemia 10.71 9.79 5 381536 3895 63103586
Ocular icterus 10.71 9.79 47 381494 3609 63103872
Therapy non-responder 10.70 9.79 361 381180 75540 63031941
Acute cutaneous lupus erythematosus 10.70 9.79 11 381530 289 63107192
Malignant polyp 10.68 9.79 9 381532 182 63107299
Anal fistula 10.64 9.79 4 381537 3547 63103934
Aortic valve incompetence 10.63 9.79 67 381474 5921 63101560
Tubulointerstitial nephritis and uveitis syndrome 10.63 9.79 10 381531 235 63107246
Ventricular tachycardia 10.63 9.79 174 381367 19805 63087676
Anisocytosis 10.63 9.79 17 381524 701 63106780
Blood glucose fluctuation 10.62 9.79 55 381486 4521 63102960
Alpha hydroxybutyrate dehydrogenase increased 10.55 9.79 4 381537 14 63107467
Muscle contracture 10.51 9.79 25 381516 1386 63106095
Psoas abscess 10.48 9.79 14 381527 489 63106992
Gout 10.48 9.79 124 381417 13147 63094334
Neutropenic sepsis 10.44 9.79 57 381484 16381 63091100
Brain stem infarction 10.42 9.79 18 381523 791 63106690
Quadriplegia 10.42 9.79 29 381512 1771 63105710
Binocular eye movement disorder 10.42 9.79 5 381536 35 63107446
Laryngotracheal oedema 10.42 9.79 5 381536 35 63107446
Cardioactive drug level increased 10.41 9.79 33 381508 2167 63105314
Blood alkaline phosphatase 10.37 9.79 8 381533 142 63107339
Atrial pressure increased 10.34 9.79 4 381537 15 63107466
Blood glucose abnormal 10.33 9.79 82 381459 7810 63099671
Atrioventricular block first degree 10.31 9.79 77 381464 7196 63100285
Glomerular filtration rate increased 10.31 9.79 19 381522 879 63106602
Cerebrovascular disorder 10.31 9.79 38 381503 2694 63104787
Acute respiratory distress syndrome 10.31 9.79 91 381450 23443 63084038
Fructosamine increased 10.30 9.79 3 381538 3 63107478
Brain stem stroke 10.27 9.79 12 381529 365 63107116
Stoma site haemorrhage 10.27 9.79 21 381520 1050 63106431
Carotid bruit 10.26 9.79 17 381524 722 63106759
Cardiac amyloidosis 10.22 9.79 18 381523 804 63106677
Congenital bowing of long bones 10.21 9.79 6 381535 66 63107415
Obstructive airways disorder 10.18 9.79 178 381363 20521 63086960
Nervousness 10.17 9.79 251 381290 30728 63076753
Erythema marginatum 10.14 9.79 4 381537 16 63107465
Blindness transient 10.12 9.79 47 381494 3697 63103784
Arterial disorder 10.11 9.79 23 381518 1238 63106243
Left ventricular end-diastolic pressure increased 10.04 9.79 12 381529 374 63107107
Mitral valve stenosis 10.04 9.79 22 381519 1155 63106326
Diastolic dysfunction 10.04 9.79 70 381471 6401 63101080
Agitated depression 10.00 9.79 10 381531 254 63107227
Exercise lack of 9.99 9.79 12 381529 376 63107105
Foot deformity 9.99 9.79 113 381428 27740 63079741
Injection site rash 9.98 9.79 69 381472 18740 63088741
Paroxysmal arrhythmia 9.96 9.79 5 381536 39 63107442
Biopsy colon abnormal 9.95 9.79 7 381534 107 63107374
Lipase increased 9.91 9.79 97 381444 9803 63097678
Toxic shock syndrome 9.90 9.79 18 381523 824 63106657
Spinal stenosis 9.90 9.79 135 381406 14790 63092691
Orthopnoea 9.87 9.79 68 381473 6193 63101288
Granulomatous dermatitis 9.87 9.79 8 381533 153 63107328
Supraventricular extrasystoles 9.87 9.79 54 381487 4535 63102946
Granuloma annulare 9.86 9.79 15 381526 592 63106889
Urinary straining 9.86 9.79 5 381536 40 63107441
Diabetes mellitus management 9.84 9.79 3 381538 4 63107477
Eczema 9.83 9.79 259 381282 32032 63075449
Small fibre neuropathy 9.82 9.79 13 381528 450 63107031
Gastroenteritis 9.82 9.79 219 381322 26371 63081110
Tension headache 9.82 9.79 59 381482 5127 63102354
Sciatica 9.82 9.79 146 381395 34178 63073303
QRS axis abnormal 9.82 9.79 21 381520 1084 63106397
Brain injury 9.82 9.79 17 381524 7026 63100455
Left atrial dilatation 9.82 9.79 29 381512 1832 63105649
Nocturia 9.80 9.79 83 381458 8058 63099423
Aggression 9.80 9.79 92 381449 23406 63084075
Lipids increased 9.79 9.79 22 381519 1175 63106306

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1303.80 11.69 2785 363856 81325 34508965
Immune-mediated myositis 1288.55 11.69 563 366078 1520 34588770
Rhabdomyolysis 838.54 11.69 2061 364580 66102 34524188
Drug abuse 579.15 11.69 161 366480 98935 34491355
Off label use 545.35 11.69 2409 364232 417115 34173175
Toxicity to various agents 532.14 11.69 799 365842 199563 34390727
Blood creatine phosphokinase increased 514.26 11.69 1321 365320 43536 34546754
Febrile neutropenia 419.92 11.69 490 366151 136359 34453931
Myopathy 415.54 11.69 558 366083 10996 34579294
Myocardial infarction 358.57 11.69 2335 364306 118750 34471540
Foetal exposure during pregnancy 356.69 11.69 9 366632 38092 34552198
Necrotising myositis 349.96 11.69 162 366479 523 34589767
Drug ineffective 346.13 11.69 3098 363543 453653 34136637
Coronary artery disease 251.42 11.69 1089 365552 47216 34543074
Pyrexia 250.57 11.69 2261 364380 330752 34259538
Neutropenia 239.66 11.69 842 365799 155936 34434354
Completed suicide 217.73 11.69 438 366203 97730 34492560
Cerebrovascular accident 209.30 11.69 1565 365076 83246 34507044
Angina pectoris 207.32 11.69 762 365879 30601 34559689
Acute myocardial infarction 205.15 11.69 1108 365533 52611 34537679
Acute kidney injury 192.81 11.69 4366 362275 300622 34289668
Premature baby 178.76 11.69 6 366635 19627 34570663
Dizziness 167.87 11.69 3220 363421 215301 34374989
Drug hypersensitivity 159.17 11.69 1413 365228 79116 34511174
Drug resistance 151.55 11.69 42 366599 25885 34564405
Low density lipoprotein increased 151.55 11.69 209 366432 4227 34586063
Chest pain 148.44 11.69 2004 364637 124758 34465532
Coronary artery stenosis 146.95 11.69 317 366324 9299 34580991
Muscular weakness 145.04 11.69 1281 365360 71616 34518674
Mucosal inflammation 139.20 11.69 120 366521 38502 34551788
Treatment failure 131.74 11.69 178 366463 46519 34543771
Autoimmune myositis 130.70 11.69 51 366590 91 34590199
Malignant neoplasm progression 130.30 11.69 479 366162 87567 34502723
Polymyositis 124.66 11.69 111 366530 1342 34588948
Product monitoring error 122.85 11.69 188 366453 4193 34586097
Muscle rupture 118.29 11.69 133 366508 2165 34588125
Muscle spasms 117.71 11.69 1254 365387 73747 34516543
Coronary artery occlusion 115.50 11.69 313 366328 10649 34579641
Cytomegalovirus infection 109.99 11.69 69 366572 26066 34564224
Platelet count decreased 108.45 11.69 772 365869 118945 34471345
Product use in unapproved indication 108.24 11.69 754 365887 116745 34473545
Disease progression 106.85 11.69 679 365962 107398 34482892
Sepsis 106.79 11.69 1174 365467 165387 34424903
Bone marrow failure 105.28 11.69 91 366550 29162 34561128
Syncope 104.60 11.69 1440 365201 90011 34500279
Ascites 103.85 11.69 207 366434 46364 34543926
Pancytopenia 101.85 11.69 583 366058 94574 34495716
Mitral valve incompetence 101.20 11.69 366 366275 14577 34575713
High density lipoprotein decreased 101.08 11.69 149 366492 3211 34587079
Drug interaction 100.76 11.69 3091 363550 222855 34367435
Myelosuppression 98.94 11.69 39 366602 19226 34571064
Erectile dysfunction 98.08 11.69 453 366188 20184 34570106
Angina unstable 98.02 11.69 307 366334 11346 34578944
Dyspnoea 97.47 11.69 4856 361785 371926 34218364
Death 97.07 11.69 3312 363329 394737 34195553
Leukopenia 96.26 11.69 337 366304 62519 34527771
White blood cell count decreased 96.22 11.69 596 366045 94849 34495441
Respiratory depression 95.53 11.69 26 366615 16219 34574071
Drug dependence 93.83 11.69 70 366571 24147 34566143
Atrial fibrillation 93.56 11.69 1803 364838 120590 34469700
Transient ischaemic attack 93.10 11.69 551 366090 27062 34563228
Acute coronary syndrome 92.78 11.69 333 366308 13212 34577078
Ischaemic stroke 92.27 11.69 408 366233 17842 34572448
Neutrophil count decreased 91.67 11.69 255 366386 50849 34539441
Type 2 diabetes mellitus 91.59 11.69 372 366269 15660 34574630
Pneumonia 89.58 11.69 3012 363629 359615 34230675
Graft versus host disease 84.53 11.69 7 366634 10562 34579728
Thrombocytopenia 80.37 11.69 1154 365487 155093 34435197
Multiple organ dysfunction syndrome 78.25 11.69 476 366165 76090 34514200
Tendon rupture 77.70 11.69 204 366437 6808 34583482
Poisoning 76.90 11.69 17 366624 12209 34578081
Cardiac failure 75.87 11.69 1362 365279 89886 34500404
Vascular stent thrombosis 75.42 11.69 121 366520 2814 34587476
Stomatitis 74.87 11.69 214 366427 42300 34547990
Suicide attempt 74.85 11.69 189 366452 38927 34551363
Intentional self-injury 73.87 11.69 26 366615 13745 34576545
Glycosylated haemoglobin increased 73.36 11.69 274 366367 11086 34579204
Labelled drug-drug interaction medication error 73.27 11.69 331 366310 14608 34575682
Infusion related reaction 72.46 11.69 298 366343 52759 34537531
Hypomagnesaemia 72.36 11.69 434 366207 21417 34568873
Product use issue 72.17 11.69 379 366262 62837 34527453
Fall 71.98 11.69 2703 363938 200182 34390108
Exposure during pregnancy 71.22 11.69 6 366635 8928 34581362
Blood triglycerides increased 71.16 11.69 316 366325 13843 34576447
Myositis 70.49 11.69 282 366359 11788 34578502
Pneumocystis jirovecii pneumonia 70.09 11.69 62 366579 19648 34570642
Low birth weight baby 69.96 11.69 3 366638 7902 34582388
Cytokine release syndrome 69.94 11.69 82 366559 22795 34567495
Product prescribing error 68.80 11.69 444 366197 22483 34567807
Asthenia 68.52 11.69 3186 363455 242065 34348225
Cardiac failure chronic 68.51 11.69 210 366431 7669 34582621
Intentional product misuse 68.18 11.69 247 366394 45364 34544926
Overdose 67.34 11.69 620 366021 90439 34499851
Muscle disorder 67.28 11.69 108 366533 2513 34587777
Haematuria 67.17 11.69 812 365829 49254 34541036
Respiratory arrest 66.59 11.69 120 366521 27923 34562367
Bronchopulmonary aspergillosis 65.50 11.69 36 366605 14623 34575667
Haemophagocytic lymphohistiocytosis 65.42 11.69 27 366614 12946 34577344
Intentional product use issue 65.31 11.69 364 366277 59452 34530838
Pain in extremity 65.15 11.69 1763 364878 124750 34465540
C-reactive protein abnormal 63.88 11.69 8 366633 8702 34581588
Low density lipoprotein decreased 63.76 11.69 69 366572 1074 34589216
Disseminated intravascular coagulation 63.73 11.69 81 366560 21735 34568555
Drug ineffective for unapproved indication 63.30 11.69 94 366547 23621 34566669
Oedema peripheral 63.23 11.69 1675 364966 118137 34472153
Myocardial necrosis marker increased 62.45 11.69 83 366558 1618 34588672
Blood cholesterol increased 62.36 11.69 399 366242 20144 34570146
Diabetic ketoacidosis 62.19 11.69 362 366279 17670 34572620
Lactic acidosis 62.00 11.69 597 366044 34175 34556115
Hyperkalaemia 61.70 11.69 1047 365594 68342 34521948
Muscle necrosis 61.20 11.69 60 366581 826 34589464
Inferior vena cava dilatation 61.15 11.69 56 366585 704 34589586
Appendicitis 61.06 11.69 40 366601 14767 34575523
Presyncope 60.86 11.69 375 366266 18684 34571606
Therapeutic product effect incomplete 60.53 11.69 298 366343 50243 34540047
Pathogen resistance 60.01 11.69 13 366628 9469 34580821
Intentional overdose 59.82 11.69 245 366396 43429 34546861
Neurotoxicity 58.97 11.69 61 366580 17949 34572341
Bradycardia 58.93 11.69 1115 365526 74303 34515987
Dermatomyositis 58.89 11.69 70 366571 1213 34589077
Rectal haemorrhage 58.52 11.69 663 365978 39586 34550704
Serotonin syndrome 58.24 11.69 74 366567 19859 34570431
Dyspnoea exertional 58.08 11.69 702 365939 42577 34547713
Upper gastrointestinal haemorrhage 57.91 11.69 462 366179 25056 34565234
Troponin increased 57.86 11.69 255 366386 11134 34579156
Therapy partial responder 57.28 11.69 15 366626 9601 34580689
Blood glucose increased 57.26 11.69 1001 365640 65717 34524573
Melaena 57.08 11.69 595 366046 34785 34555505
Ejection fraction decreased 56.29 11.69 369 366272 18785 34571505
Muscle atrophy 55.89 11.69 188 366453 7216 34583074
Immune reconstitution inflammatory syndrome 55.45 11.69 12 366629 8747 34581543
Amnesia 54.96 11.69 471 366170 26092 34564198
Venoocclusive liver disease 54.50 11.69 9 366632 7957 34582333
Ischaemic cardiomyopathy 54.36 11.69 169 366472 6220 34584070
Infection 53.82 11.69 652 365989 90263 34500027
Aspergillus infection 53.45 11.69 31 366610 12223 34578067
Posterior reversible encephalopathy syndrome 53.04 11.69 19 366622 9935 34580355
N-terminal prohormone brain natriuretic peptide increased 52.84 11.69 99 366542 2616 34587674
Myopathy toxic 52.74 11.69 46 366595 540 34589750
Respiratory failure 52.63 11.69 811 365830 107761 34482529
Condition aggravated 51.44 11.69 1579 365062 190617 34399673
Mixed liver injury 51.30 11.69 101 366540 2772 34587518
Glomerular filtration rate decreased 51.24 11.69 270 366371 12691 34577599
Septic shock 51.00 11.69 494 366147 71340 34518950
Muscle injury 50.85 11.69 70 366571 1413 34588877
Hypoglycaemia 49.49 11.69 827 365814 53813 34536477
Epstein-Barr virus infection 49.22 11.69 10 366631 7618 34582672
Cardiac disorder 47.21 11.69 674 365967 42452 34547838
Chromaturia 47.18 11.69 287 366354 14233 34576057
Hypotension 46.82 11.69 2805 363836 218844 34371446
Haematotoxicity 46.54 11.69 14 366627 8180 34582110
Seizure 45.62 11.69 799 365842 104058 34486232
Ventricular hypokinesia 45.53 11.69 145 366496 5407 34584883
Post transplant lymphoproliferative disorder 45.51 11.69 7 366634 6521 34583769
Low density lipoprotein abnormal 45.10 11.69 34 366607 319 34589971
Hepatitis cholestatic 45.07 11.69 184 366457 7763 34582527
Agitation 44.53 11.69 386 366255 57013 34533277
Hepatic cytolysis 44.27 11.69 282 366359 14214 34576076
Product substitution issue 43.90 11.69 216 366425 9879 34580411
Vomiting 43.70 11.69 2137 364504 245484 34344806
Neoplasm progression 43.48 11.69 114 366527 23186 34567104
Hepatic encephalopathy 43.44 11.69 54 366587 14631 34575659
Tumour lysis syndrome 43.25 11.69 70 366571 16989 34573301
Psoriasis 43.05 11.69 608 366033 38204 34552086
Amyotrophic lateral sclerosis 42.60 11.69 53 366588 965 34589325
Orthostatic hypotension 42.33 11.69 437 366204 25482 34564808
Cystitis haemorrhagic 42.18 11.69 5 366636 5674 34584616
Faeces discoloured 41.54 11.69 283 366358 14595 34575695
Atrial septal defect 41.32 11.69 13 366628 7379 34582911
Acute myeloid leukaemia 40.89 11.69 81 366560 18189 34572101
Progressive multifocal leukoencephalopathy 40.77 11.69 26 366615 9738 34580552
Blood cholesterol decreased 40.74 11.69 53 366588 1011 34589279
Myocardial ischaemia 40.50 11.69 317 366324 17091 34573199
Pancreatitis acute 40.20 11.69 462 366179 27679 34562611
Coronary artery bypass 40.17 11.69 128 366513 4774 34585516
Hypertensive emergency 40.12 11.69 52 366589 988 34589302
Cardiac failure congestive 39.36 11.69 1148 365493 82122 34508168
Carotid artery stenosis 39.27 11.69 129 366512 4890 34585400
Exercise tolerance decreased 39.25 11.69 132 366509 5066 34585224
Akathisia 39.11 11.69 18 366623 8091 34582199
Hepatocellular injury 38.93 11.69 380 366261 21831 34568459
Muscle enzyme increased 37.99 11.69 28 366613 253 34590037
Tricuspid valve incompetence 37.68 11.69 202 366439 9558 34580732
Neuroleptic malignant syndrome 37.21 11.69 83 366558 17851 34572439
Computerised tomogram coronary artery abnormal 37.19 11.69 25 366616 192 34590098
Polymyalgia rheumatica 37.10 11.69 61 366580 1449 34588841
Arteriosclerosis coronary artery 36.97 11.69 241 366400 12244 34578046
Exercise lack of 36.90 11.69 21 366620 115 34590175
Electrocardiogram abnormal 36.81 11.69 193 366448 9054 34581236
Haemorrhagic stroke 36.77 11.69 151 366490 6388 34583902
Intermittent claudication 36.63 11.69 77 366564 2217 34588073
Arteriosclerosis 36.04 11.69 232 366409 11736 34578554
Cardio-respiratory arrest 35.18 11.69 390 366251 54883 34535407
Cerebral haemorrhage 35.09 11.69 538 366103 34399 34555891
Maternal exposure during pregnancy 34.92 11.69 5 366636 4913 34585377
Nocturia 34.57 11.69 204 366437 10006 34580284
Blood cholesterol 34.03 11.69 24 366617 201 34590089
Substance abuse 33.80 11.69 19 366622 7622 34582668
Coma 33.75 11.69 311 366330 45367 34544923
Restlessness 33.62 11.69 145 366496 25337 34564953
Cytomegalovirus viraemia 33.56 11.69 18 366623 7412 34582878
Cytopenia 33.40 11.69 51 366590 12672 34577618
Somnolence 32.92 11.69 900 365741 110216 34480074
Drug use disorder 32.91 11.69 3 366638 4188 34586102
Palpitations 32.89 11.69 596 366045 39390 34550900
Lymphocyte count decreased 32.82 11.69 124 366517 22498 34567792
Coronary artery restenosis 32.77 11.69 47 366594 987 34589303
Drug withdrawal syndrome 32.64 11.69 103 366538 19731 34570559
Diabetic nephropathy 32.34 11.69 70 366571 2058 34588232
Autoimmune hepatitis 32.29 11.69 110 366531 4250 34586040
Enterococcal infection 32.22 11.69 30 366611 9276 34581014
Haematoma 32.05 11.69 410 366231 25195 34565095
Haematochezia 31.67 11.69 674 365967 45860 34544430
Heart rate irregular 31.51 11.69 278 366363 15529 34574761
Febrile bone marrow aplasia 31.45 11.69 24 366617 8185 34582105
Myelodysplastic syndrome 31.43 11.69 100 366541 19108 34571182
Hypocalcaemia 31.29 11.69 391 366250 23898 34566392
Status epilepticus 30.83 11.69 53 366588 12561 34577729
Diabetes mellitus inadequate control 30.67 11.69 244 366397 13220 34577070
Bacteraemia 30.65 11.69 105 366536 19612 34570678
Sedation 30.57 11.69 115 366526 20891 34569399
Blood loss anaemia 30.56 11.69 168 366473 8026 34582264
Muscle fatigue 30.50 11.69 55 366586 1410 34588880
Genital swelling 30.35 11.69 20 366621 148 34590142
Liver function test abnormal 30.25 11.69 476 366165 30598 34559692
Tendonitis 29.91 11.69 181 366460 8959 34581331
Aggression 29.78 11.69 263 366378 38701 34551589
Blood creatine phosphokinase MB increased 29.76 11.69 63 366578 1823 34588467
Acute respiratory distress syndrome 29.45 11.69 156 366485 25813 34564477
Vascular stent stenosis 29.41 11.69 48 366593 1133 34589157
Respiratory distress 29.39 11.69 236 366405 35429 34554861
Stent placement 29.14 11.69 118 366523 4960 34585330
Normocytic anaemia 28.89 11.69 71 366570 2273 34588017
Nipple pain 28.83 11.69 42 366599 895 34589395
Cholestasis 28.62 11.69 419 366222 26529 34563761
Transplant rejection 28.37 11.69 40 366601 10271 34580019
Gastrointestinal haemorrhage 28.28 11.69 1166 365475 87311 34502979
Abdominal pain 28.23 11.69 1415 365226 162203 34428087
Psychotic disorder 28.23 11.69 146 366495 24306 34565984
Hepatitis C 28.19 11.69 37 366604 9793 34580497
Dermatitis atopic 28.14 11.69 121 366520 5226 34585064
Blood cholesterol abnormal 28.12 11.69 60 366581 1746 34588544
Nail avulsion 28.06 11.69 11 366630 20 34590270
Musculoskeletal pain 27.92 11.69 481 366160 31482 34558808
Candida infection 27.76 11.69 94 366547 17621 34572669
Loss of personal independence in daily activities 27.60 11.69 219 366422 32960 34557330
Glycogen storage disease type V 27.56 11.69 12 366629 32 34590258
Hepatitis B reactivation 27.52 11.69 4 366637 3887 34586403
Aplastic anaemia 27.43 11.69 37 366604 9679 34580611
Degenerative mitral valve disease 27.13 11.69 23 366618 259 34590031
Cytomegalovirus chorioretinitis 27.06 11.69 3 366638 3586 34586704
Dyspnoea at rest 26.97 11.69 95 366546 3733 34586557
Pollakiuria 26.77 11.69 320 366321 19354 34570936
Bacterial infection 26.43 11.69 91 366550 16972 34573318
Anti-neutrophil cytoplasmic antibody positive vasculitis 26.24 11.69 40 366601 889 34589401
Miosis 26.22 11.69 37 366604 9498 34580792
Type V hyperlipidaemia 26.15 11.69 37 366604 767 34589523
Nipple swelling 26.12 11.69 24 366617 303 34589987
Dystonia 26.11 11.69 46 366595 10799 34579491
Idiopathic pulmonary fibrosis 26.03 11.69 89 366552 3445 34586845
Muscle discomfort 25.94 11.69 16 366625 104 34590186
Product odour abnormal 25.67 11.69 36 366605 740 34589550
Carotid artery disease 25.35 11.69 39 366602 874 34589416
Foetal growth restriction 25.34 11.69 6 366635 4111 34586179
Cardiac aneurysm 25.25 11.69 40 366601 920 34589370
Cytomegalovirus infection reactivation 25.25 11.69 11 366630 5107 34585183
Pulmonary valve incompetence 25.15 11.69 39 366602 880 34589410
Depressed level of consciousness 25.04 11.69 308 366333 42533 34547757
Iliac artery stenosis 24.84 11.69 14 366627 75 34590215
Oropharyngeal pain 24.76 11.69 245 366396 35240 34555050
Nephropathy toxic 24.72 11.69 60 366581 12528 34577762
Swollen tongue 24.68 11.69 248 366393 14357 34575933
Blood urea abnormal 24.55 11.69 36 366605 772 34589518
Hypogammaglobulinaemia 24.46 11.69 27 366614 7713 34582577
Blood phosphorus increased 24.33 11.69 27 366614 7694 34582596
Arterial occlusive disease 24.30 11.69 100 366541 4234 34586056
Ventricular septal defect 24.30 11.69 6 366635 3995 34586295
Ocular myasthenia 24.26 11.69 20 366621 216 34590074
Hyperlipidaemia 24.21 11.69 246 366395 14283 34576007
Haemorrhagic transformation stroke 24.18 11.69 51 366590 1472 34588818
Stenosis 24.17 11.69 50 366591 1423 34588867
Pulmonary vascular disorder 24.16 11.69 33 366608 661 34589629
Abnormal behaviour 24.06 11.69 158 366483 24811 34565479
Chest discomfort 23.93 11.69 745 365896 53785 34536505
Myoglobin blood increased 23.92 11.69 78 366563 2945 34587345
Hepatitis acute 23.91 11.69 149 366492 7452 34582838
Nocardiosis 23.85 11.69 6 366635 3945 34586345
Incorrect route of product administration 23.79 11.69 78 366563 14767 34575523
Oesophageal carcinoma 23.75 11.69 38 366603 9266 34581024
Balance disorder 23.65 11.69 576 366065 40078 34550212
Pulmonary haemorrhage 23.65 11.69 45 366596 10259 34580031
Pneumatosis intestinalis 23.60 11.69 6 366635 3917 34586373
Essential hypertension 23.54 11.69 78 366563 2970 34587320
Shock haemorrhagic 23.31 11.69 201 366440 11153 34579137
C-reactive protein increased 23.26 11.69 413 366228 53685 34536605
Urinary retention 23.22 11.69 521 366120 35767 34554523
Blood immunoglobulin E increased 23.21 11.69 69 366572 2477 34587813
Left atrial dilatation 23.07 11.69 59 366582 1937 34588353
Immunisation reaction 23.00 11.69 11 366630 39 34590251
Hepatocellular carcinoma 22.86 11.69 27 366614 7482 34582808
Cerebral infarction 22.85 11.69 410 366231 27045 34563245
Pseudomonas infection 22.78 11.69 61 366580 12321 34577969
Cardiac failure acute 22.69 11.69 189 366452 10381 34579909
Fungal infection 22.69 11.69 88 366553 15847 34574443
Enthesopathy 22.62 11.69 10 366631 4603 34585687
Central obesity 22.56 11.69 30 366611 585 34589705
Skin toxicity 22.48 11.69 11 366630 4773 34585517
Patent ductus arteriosus 22.48 11.69 4 366637 3350 34586940
Paradoxical drug reaction 22.46 11.69 4 366637 3347 34586943
Ventricular enlargement 22.25 11.69 31 366610 633 34589657
Pneumonia fungal 22.18 11.69 25 366616 7075 34583215
Device related infection 22.18 11.69 99 366542 17138 34573152
Chronic coronary syndrome 22.17 11.69 17 366624 164 34590126
Peripheral vascular disorder 22.07 11.69 108 366533 4928 34585362
Lymph node calcification 21.94 11.69 16 366625 142 34590148
Hepatic enzyme increased 21.93 11.69 551 366090 38529 34551761
Pneumonia cytomegaloviral 21.93 11.69 3 366638 3051 34587239
Systemic candida 21.84 11.69 6 366635 3720 34586570
Immune effector cell-associated neurotoxicity syndrome 21.72 11.69 6 366635 3707 34586583
Klebsiella infection 21.63 11.69 35 366606 8496 34581794
Therapy non-responder 21.55 11.69 285 366356 38861 34551429
Eye injury 21.51 11.69 35 366606 824 34589466
Left atrial enlargement 21.48 11.69 36 366605 869 34589421
Nausea 21.33 11.69 3184 363457 336724 34253566
Peripheral artery occlusion 21.25 11.69 52 366589 1660 34588630
Sinusitis 21.16 11.69 306 366335 41096 34549194
Gait disturbance 21.15 11.69 1094 365547 84046 34506244
Apparent death 21.11 11.69 6 366635 3638 34586652
Cardiotoxicity 21.02 11.69 17 366624 5631 34584659
Atrioventricular block second degree 20.92 11.69 87 366554 3701 34586589
Systemic infection 20.89 11.69 109 366532 5103 34585187
Toxic epidermal necrolysis 20.84 11.69 137 366504 21509 34568781
Arterial stenosis 20.83 11.69 41 366600 1125 34589165
Therapeutic product effect decreased 20.60 11.69 249 366392 34494 34555796
Abnormal weight gain 20.49 11.69 38 366603 996 34589294
Synovitis 20.47 11.69 77 366564 13989 34576301
Ventricular internal diameter abnormal 20.45 11.69 17 366624 186 34590104
Pelvic mass 20.39 11.69 18 366623 215 34590075
Sleep disorder due to a general medical condition 20.34 11.69 15 366626 5206 34585084
Potassium wasting nephropathy 20.19 11.69 13 366628 92 34590198
Venoocclusive disease 20.16 11.69 3 366638 2864 34587426
Catatonia 20.15 11.69 14 366627 5011 34585279
Scrotal pain 20.14 11.69 35 366606 871 34589419
Lymphadenopathy 20.08 11.69 196 366445 28267 34562023
Rhinovirus infection 20.03 11.69 10 366631 4289 34586001
Accidental exposure to product 20.01 11.69 68 366573 12734 34577556
Pruritus 19.96 11.69 1739 364902 140242 34450048
Radiculitis brachial 19.92 11.69 8 366633 16 34590274
Hepatitis B 19.89 11.69 20 366621 5963 34584327
Ageusia 19.88 11.69 180 366461 10128 34580162
Quadriparesis 19.84 11.69 48 366593 1521 34588769
Lipids abnormal 19.78 11.69 23 366618 389 34589901
Pneumonitis 19.63 11.69 244 366397 33634 34556656
Gastrointestinal angiodysplasia 19.63 11.69 28 366613 585 34589705
Hypoalbuminaemia 19.49 11.69 64 366577 12110 34578180
Ventricular dyskinesia 19.48 11.69 18 366623 229 34590061
Nicotine dependence 19.45 11.69 28 366613 590 34589700
Chronic kidney disease 19.41 11.69 568 366073 40642 34549648
Diffuse large B-cell lymphoma recurrent 19.29 11.69 5 366636 3223 34587067
Brain oedema 19.25 11.69 77 366564 13744 34576546
Aldolase increased 19.22 11.69 11 366630 61 34590229
Cardiac valve disease 19.13 11.69 74 366567 3044 34587246
Ventricular arrhythmia 19.07 11.69 111 366530 5417 34584873
Mydriasis 19.00 11.69 29 366612 7208 34583082
Arrhythmia 18.96 11.69 501 366140 35307 34554983
Colitis 18.95 11.69 280 366361 37470 34552820
Rheumatoid nodule 18.73 11.69 4 366637 2943 34587347
Transplant failure 18.56 11.69 7 366634 3546 34586744
Obstructive pancreatitis 18.48 11.69 27 366614 577 34589713
Penile haemorrhage 18.47 11.69 28 366613 619 34589671
Palmar-plantar erythrodysaesthesia syndrome 18.43 11.69 102 366539 16693 34573597
Deep vein thrombosis 18.41 11.69 532 366109 64716 34525574
Memory impairment 18.26 11.69 589 366052 42729 34547561
Penis injury 18.18 11.69 18 366623 251 34590039
Polyp 18.17 11.69 85 366556 3807 34586483
Microcytic anaemia 18.17 11.69 61 366580 2339 34587951
Diabetes mellitus 18.14 11.69 631 366010 46242 34544048
Post micturition dribble 18.11 11.69 7 366634 12 34590278
Hyperbilirubinaemia 18.10 11.69 103 366538 16740 34573550
Vertigo 18.06 11.69 372 366269 25164 34565126
Acquired claw toe 18.01 11.69 9 366632 36 34590254
Herpes simplex 18.00 11.69 19 366622 5540 34584750
Lacunar infarction 17.88 11.69 72 366569 3018 34587272
Blood glucose decreased 17.87 11.69 215 366426 13022 34577268
Epilepsy 17.82 11.69 142 366499 21353 34568937
Peripheral arterial occlusive disease 17.77 11.69 114 366527 5760 34584530
Neutropenic sepsis 17.76 11.69 79 366562 13688 34576602
Atrial flutter 17.68 11.69 245 366396 15329 34574961
Infective exacerbation of chronic obstructive airways disease 17.67 11.69 51 366590 1800 34588490
Thrombotic microangiopathy 17.63 11.69 55 366586 10575 34579715
Vascular graft 17.60 11.69 45 366596 1477 34588813
Withdrawal syndrome 17.60 11.69 69 366572 12386 34577904
Cardiovascular disorder 17.60 11.69 172 366469 9884 34580406
Epicondylitis 17.52 11.69 24 366617 482 34589808
Musculoskeletal stiffness 17.42 11.69 365 366276 46315 34543975
Hypercholesterolaemia 17.41 11.69 154 366487 8608 34581682
Therapeutic response decreased 17.41 11.69 210 366431 29103 34561187
Hepatic failure 17.37 11.69 256 366385 34275 34556015
Haemorrhage intracranial 17.35 11.69 249 366392 15697 34574593
Cardiomyopathy 17.32 11.69 260 366381 16548 34573742
Occupational problem environmental 17.31 11.69 6 366635 6 34590284
Avoidant personality disorder 17.31 11.69 6 366635 6 34590284
Pneumothorax 17.31 11.69 123 366518 18969 34571321
Shock 17.26 11.69 166 366475 24013 34566277
Large intestine polyp 17.25 11.69 142 366499 7772 34582518
Blood pressure increased 17.25 11.69 1108 365533 86994 34503296
Peripheral artery stenosis 17.22 11.69 32 366609 840 34589450
Hyperammonaemia 17.22 11.69 25 366616 6342 34583948
Intraventricular haemorrhage 17.14 11.69 78 366563 3453 34586837
Hypertransaminasaemia 17.08 11.69 109 366532 5497 34584793
BK virus infection 17.07 11.69 21 366620 5717 34584573
Pericardial haemorrhage 17.03 11.69 72 366569 3086 34587204
Eructation 16.98 11.69 96 366545 4635 34585655
Clonus 16.94 11.69 4 366637 2746 34587544
Blood pressure fluctuation 16.92 11.69 176 366465 25073 34565217
Colorectal cancer 16.90 11.69 15 366626 4746 34585544
Blood creatine increased 16.81 11.69 99 366542 4852 34585438
Staphylococcal infection 16.78 11.69 242 366399 32518 34557772
Weight decreased 16.77 11.69 2103 364538 174198 34416092
Neutropenic colitis 16.75 11.69 6 366635 3138 34587152
Cytomegalovirus test positive 16.71 11.69 10 366631 3876 34586414
Orthopnoea 16.66 11.69 101 366540 5002 34585288
Muscle contractions involuntary 16.63 11.69 50 366591 1806 34588484
Macroglossia 16.56 11.69 21 366620 390 34589900
Muscle strain 16.53 11.69 84 366557 3892 34586398
Clostridium difficile colitis 16.47 11.69 97 366544 15633 34574657
Transient global amnesia 16.46 11.69 20 366621 355 34589935
Ataxia 16.39 11.69 82 366559 13771 34576519
Product administered to patient of inappropriate age 16.35 11.69 7 366634 3284 34587006
Electrocardiogram ST segment depression 16.33 11.69 60 366581 2408 34587882
Anticoagulation drug level increased 16.32 11.69 24 366617 516 34589774
Herbal interaction 16.29 11.69 20 366621 359 34589931
Vision blurred 16.14 11.69 612 366029 45351 34544939
Aortic valve replacement 16.06 11.69 30 366611 791 34589499
Mastitis 16.01 11.69 14 366627 165 34590125
Drug intolerance 15.99 11.69 489 366152 59081 34531209
Neurodermatitis 15.95 11.69 19 366622 330 34589960
Blood creatine phosphokinase abnormal 15.89 11.69 16 366625 228 34590062
Drug abuser 15.87 11.69 11 366630 3943 34586347
Peripheral paralysis 15.82 11.69 8 366633 33 34590257
Glycosylated haemoglobin abnormal 15.81 11.69 14 366627 168 34590122
Hepatic fibrosis 15.78 11.69 15 366626 4592 34585698
Abscess 15.73 11.69 67 366574 11750 34578540
Neuromyopathy 15.70 11.69 34 366607 1000 34589290
Urine flow decreased 15.67 11.69 38 366603 1206 34589084
Cold sweat 15.65 11.69 167 366474 9820 34580470
Heart valve incompetence 15.62 11.69 42 366599 1422 34588868
Vitreous detachment 15.59 11.69 31 366610 857 34589433
Intercepted product preparation error 15.52 11.69 12 366629 4066 34586224
Aortic aneurysm 15.52 11.69 123 366518 6656 34583634
Hiatus hernia 15.52 11.69 135 366506 7510 34582780
Osteonecrosis 15.49 11.69 92 366549 14798 34575492
Gout 15.49 11.69 286 366355 18967 34571323
Portal hypertension 15.40 11.69 12 366629 4050 34586240
Bronchiectasis 15.36 11.69 52 366589 9749 34580541
Haematoma muscle 15.36 11.69 40 366601 1328 34588962
Lipodystrophy acquired 15.25 11.69 8 366633 3336 34586954
Drug level increased 15.23 11.69 153 366488 21943 34568347
Dysmorphism 15.23 11.69 7 366634 3149 34587141
Tuberculosis 15.22 11.69 43 366598 8534 34581756
Migraine 15.17 11.69 114 366527 17364 34572926
Altered state of consciousness 15.17 11.69 160 366481 22733 34567557
Adrenal insufficiency 15.04 11.69 86 366555 13961 34576329
Hypertension 15.03 11.69 1643 364998 134800 34455490
Dyspnoea paroxysmal nocturnal 14.99 11.69 42 366599 1457 34588833
Herpes zoster 14.98 11.69 262 366379 34137 34556153
Upper respiratory tract infection 14.97 11.69 250 366391 32809 34557481
Left ventricular dilatation 14.97 11.69 28 366613 739 34589551
Burning feet syndrome 14.96 11.69 11 366630 99 34590191
Hepatosplenomegaly 14.96 11.69 13 366628 4156 34586134
Staphylococcal sepsis 14.91 11.69 53 366588 9791 34580499
Blood electrolytes abnormal 14.89 11.69 32 366609 936 34589354
Bilirubin conjugated abnormal 14.78 11.69 11 366630 101 34590189
Toe amputation 14.76 11.69 59 366582 2465 34587825
Hepatic vein dilatation 14.72 11.69 15 366626 217 34590073
Dyskinesia 14.71 11.69 157 366484 22256 34568034
Basal ganglia haemorrhage 14.69 11.69 31 366610 895 34589395
Wound haematoma 14.65 11.69 9 366632 58 34590232
Mitochondrial toxicity 14.64 11.69 5 366636 2694 34587596
Injection site erythema 14.62 11.69 102 366539 15797 34574493
Ileus 14.62 11.69 107 366534 16392 34573898
Hyponatraemic syndrome 14.61 11.69 14 366627 187 34590103
Left ventricular dysfunction 14.61 11.69 165 366476 9842 34580448
Angiocardiogram 14.56 11.69 14 366627 188 34590102
Autoimmune myocarditis 14.55 11.69 15 366626 220 34590070
Carcinoid tumour of the gastrointestinal tract 14.53 11.69 9 366632 59 34590231
Bundle branch block left 14.53 11.69 110 366531 5869 34584421
Inflammation 14.50 11.69 209 366432 28086 34562204
International normalised ratio increased 14.50 11.69 621 366020 46706 34543584
Cardiac stress test abnormal 14.46 11.69 19 366622 366 34589924
Osteonecrosis of jaw 14.45 11.69 119 366522 17770 34572520
Encephalopathy 14.44 11.69 272 366369 35047 34555243
Urosepsis 14.39 11.69 201 366440 12598 34577692
Subdural haematoma 14.28 11.69 297 366344 20124 34570166
Cells in urine 14.27 11.69 4 366637 0 34590290
Clostridium difficile infection 14.24 11.69 128 366513 18770 34571520
Alcohol abuse 14.13 11.69 17 366624 4673 34585617
Renal impairment 14.12 11.69 1163 365478 93350 34496940
Food interaction 14.08 11.69 31 366610 922 34589368
Hepatic cirrhosis 14.06 11.69 115 366526 17199 34573091
AST/ALT ratio abnormal 14.05 11.69 6 366635 15 34590275
Peripheral ischaemia 14.03 11.69 105 366536 5582 34584708
Congenital diaphragmatic anomaly 14.00 11.69 7 366634 28 34590262
Urticaria chronic 13.96 11.69 10 366631 86 34590204
Speech disorder developmental 13.96 11.69 3 366638 2197 34588093
Miller Fisher syndrome 13.95 11.69 11 366630 111 34590179
Sinus bradycardia 13.94 11.69 202 366439 12761 34577529
Autoimmune disorder 13.94 11.69 46 366595 1748 34588542
Splenomegaly 13.89 11.69 97 366544 15020 34575270
Discoloured vomit 13.89 11.69 22 366619 506 34589784
Fibrous histiocytoma 13.85 11.69 13 366628 169 34590121
Pseudohyponatraemia 13.83 11.69 9 366632 65 34590225
Staphylococcal bacteraemia 13.83 11.69 44 366597 8408 34581882
Thrombocytopenic purpura 13.82 11.69 35 366606 1142 34589148
Tunnel vision 13.76 11.69 23 366618 554 34589736
Oscillopsia 13.75 11.69 8 366633 46 34590244
Encephalitis toxic 13.70 11.69 16 366625 272 34590018
Ventricular hypertrophy 13.68 11.69 89 366552 4518 34585772
Generalised tonic-clonic seizure 13.62 11.69 149 366492 21025 34569265
Agonal rhythm 13.61 11.69 9 366632 67 34590223
Neuropathy peripheral 13.59 11.69 724 365917 82539 34507751
Behaviour disorder 13.55 11.69 19 366622 4891 34585399
Euphoric mood 13.51 11.69 24 366617 5617 34584673
Lymphoproliferative disorder 13.50 11.69 6 366635 2753 34587537
Lymphopenia 13.50 11.69 108 366533 16227 34574063
Brain abscess 13.50 11.69 8 366633 3117 34587173
Pneumonia klebsiella 13.49 11.69 9 366632 3291 34586999
Angioedema 13.45 11.69 499 366142 36875 34553415
Escherichia infection 13.44 11.69 43 366598 8202 34582088
Psychiatric decompensation 13.43 11.69 7 366634 2930 34587360
Non-cardiac chest pain 13.37 11.69 84 366557 4213 34586077
Euglycaemic diabetic ketoacidosis 13.34 11.69 68 366573 3154 34587136
Liver palpable 13.34 11.69 16 366625 280 34590010
Antipsychotic drug level below therapeutic 13.34 11.69 5 366636 2542 34587748
Hemianaesthesia 13.33 11.69 10 366631 93 34590197
Implantable defibrillator insertion 13.30 11.69 27 366614 758 34589532
Pneumonia aspiration 13.29 11.69 336 366305 41567 34548723
Systolic dysfunction 13.28 11.69 60 366581 2648 34587642
Chronic obstructive pulmonary disease 13.27 11.69 634 366007 48284 34542006
Liver transplant 13.23 11.69 5 366636 2529 34587761
Erythema 13.20 11.69 779 365862 88001 34502289
Duodenal ulcer haemorrhage 13.19 11.69 94 366547 4919 34585371
Peritonitis 13.16 11.69 109 366532 16256 34574034
Diabetic foot 13.10 11.69 61 366580 2727 34587563
Obsessive-compulsive disorder 13.03 11.69 24 366617 5540 34584750
Gait inability 12.96 11.69 297 366344 20461 34569829
Brain stem haematoma 12.90 11.69 11 366630 125 34590165
Human herpesvirus 6 infection 12.87 11.69 3 366638 2078 34588212
Atrioventricular block complete 12.86 11.69 152 366489 9167 34581123
Renal cyst 12.86 11.69 149 366492 8944 34581346
Prostatomegaly 12.83 11.69 98 366543 5243 34585047
Normal tension glaucoma 12.82 11.69 6 366635 20 34590270
Adenocarcinoma gastric 12.78 11.69 35 366606 1198 34589092
Tachycardia 12.75 11.69 743 365898 84029 34506261
Pancreatitis 12.75 11.69 514 366127 38377 34551913
Personality change 12.74 11.69 95 366546 5044 34585246
Dysstasia 12.71 11.69 189 366452 12006 34578284
Electrocardiogram ST-T change 12.67 11.69 22 366619 547 34589743
Sensory level abnormal 12.60 11.69 6 366635 21 34590269
Diabetic metabolic decompensation 12.59 11.69 44 366597 1722 34588568
Brain natriuretic peptide increased 12.59 11.69 102 366539 5557 34584733
Sinus node dysfunction 12.57 11.69 82 366559 4167 34586123
Psychomotor hyperactivity 12.54 11.69 55 366586 9567 34580723
Blood thyroid stimulating hormone increased 12.52 11.69 82 366559 4173 34586117
Blood triglycerides decreased 12.51 11.69 10 366631 103 34590187
Lipid metabolism disorder 12.50 11.69 17 366624 339 34589951
Oxygen saturation decreased 12.50 11.69 450 366191 53368 34536922
Hypoxia 12.50 11.69 462 366179 54633 34535657
Lipoprotein (a) increased 12.50 11.69 8 366633 56 34590234
Carotid endarterectomy 12.50 11.69 8 366633 56 34590234
Uveitis 12.49 11.69 39 366602 7496 34582794
Smooth muscle antibody positive 12.45 11.69 5 366636 10 34590280
Mitral valve calcification 12.45 11.69 22 366619 555 34589735
Mitral valve repair 12.40 11.69 6 366635 22 34590268
Impatience 12.35 11.69 17 366624 343 34589947
Retroperitoneal fibrosis 12.34 11.69 18 366623 384 34589906
Abnormal clotting factor 12.33 11.69 9 366632 80 34590210
Micturition frequency decreased 12.32 11.69 17 366624 344 34589946
Diffuse large B-cell lymphoma 12.32 11.69 38 366603 7332 34582958
Vascular graft occlusion 12.31 11.69 22 366619 560 34589730
Spur cell anaemia 12.27 11.69 8 366633 58 34590232
Laryngeal haematoma 12.25 11.69 12 366629 165 34590125
Atrioventricular block 12.25 11.69 134 366507 7929 34582361
Respiratory syncytial virus infection 12.24 11.69 19 366622 4690 34585600
Flatulence 12.22 11.69 300 366341 20898 34569392
Escherichia sepsis 12.21 11.69 19 366622 4685 34585605
Drug screen positive 12.19 11.69 14 366627 3929 34586361
Extrapyramidal disorder 12.16 11.69 82 366559 12798 34577492
Benign pancreatic neoplasm 12.14 11.69 5 366636 11 34590279
Abnormal loss of weight 12.14 11.69 79 366562 4011 34586279
Myoglobin urine present 12.14 11.69 12 366629 167 34590123
JC virus infection 12.14 11.69 4 366637 2204 34588086
Conjunctival hyperaemia 12.11 11.69 5 366636 2397 34587893
Panniculitis 12.09 11.69 3 366638 1991 34588299
Arterial repair 12.07 11.69 4 366637 3 34590287
Inferior vena cava syndrome 12.05 11.69 8 366633 60 34590230
Injection site pain 12.04 11.69 314 366327 38691 34551599
Ammonia increased 11.97 11.69 17 366624 4352 34585938
Congestive cardiomyopathy 11.96 11.69 126 366515 7384 34582906
Aortic valve calcification 11.96 11.69 17 366624 354 34589936
Atheroembolism 11.96 11.69 16 366625 314 34589976
Product contamination physical 11.93 11.69 7 366634 41 34590249
Fungaemia 11.93 11.69 6 366635 2562 34587728
Device related sepsis 11.90 11.69 9 366632 3084 34587206
Occult blood positive 11.90 11.69 78 366563 3970 34586320
Intestinal obstruction 11.90 11.69 168 366473 22654 34567636
Mycobacterial infection 11.87 11.69 5 366636 2369 34587921
Oesophageal pain 11.86 11.69 27 366614 822 34589468
Bradyarrhythmia 11.85 11.69 50 366591 2141 34588149
Blood pressure inadequately controlled 11.85 11.69 57 366584 2583 34587707
Cerebral haematoma 11.84 11.69 86 366555 4529 34585761
Angioplasty 11.82 11.69 30 366611 980 34589310
Hypoaesthesia eye 11.82 11.69 6 366635 25 34590265
Diabetic neuropathy 11.81 11.69 80 366561 4117 34586173
Hepatojugular reflux 11.80 11.69 22 366619 579 34589711
Pyonephrosis 11.74 11.69 8 366633 63 34590227

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Immune-mediated myositis 2173.19 10.45 872 629441 2595 79111480
Myalgia 1933.71 10.45 4425 625888 181216 78932859
Rhabdomyolysis 1810.86 10.45 3063 627250 100068 79014007
Drug ineffective 939.75 10.45 4883 625430 1076030 78038045
Acute kidney injury 938.63 10.45 7166 623147 512238 78601837
Maternal exposure during pregnancy 888.92 10.45 46 630267 136492 78977583
Myopathy 817.06 10.45 908 629405 19655 79094420
Blood creatine phosphokinase increased 801.25 10.45 1676 628637 64414 79049661
Myocardial infarction 791.71 10.45 3216 627097 180913 78933162
Off label use 759.53 10.45 4148 626165 903067 78211008
Hand deformity 655.00 10.45 42 630271 103877 79010198
Cerebrovascular accident 647.37 10.45 2687 627626 152605 78961470
Pemphigus 643.61 10.45 35 630278 99547 79014528
Toxicity to various agents 624.74 10.45 1516 628797 420024 78694051
Necrotising myositis 593.34 10.45 259 630054 1009 79113066
Synovitis 592.14 10.45 225 630088 150509 78963566
Exposure during pregnancy 587.03 10.45 59 630254 101073 79013002
Drug abuse 560.35 10.45 293 630020 162398 78951677
Coronary artery disease 560.05 10.45 1448 628865 64026 79050049
Acute myocardial infarction 546.76 10.45 1591 628722 75445 79038630
Systemic lupus erythematosus 517.21 10.45 157 630156 120992 78993083
Glossodynia 513.53 10.45 97 630216 103240 79010835
Treatment failure 503.96 10.45 367 629946 170119 78943956
Completed suicide 496.34 10.45 733 629580 245034 78869041
Infusion related reaction 460.71 10.45 691 629622 229546 78884529
Pericarditis 454.23 10.45 130 630183 104106 79009969
Contraindicated product administered 452.92 10.45 349 629964 157189 78956886
Drug interaction 439.51 10.45 5115 625198 410068 78704007
Rheumatoid factor positive 428.49 10.45 9 630304 59830 79054245
Therapeutic product effect decreased 424.68 10.45 401 629912 163462 78950613
Febrile neutropenia 399.75 10.45 761 629552 230238 78883837
Drug intolerance 398.65 10.45 940 629373 263179 78850896
Duodenal ulcer perforation 393.86 10.45 35 630278 66176 79047899
Arthropathy 375.57 10.45 510 629803 176601 78937474
Angina pectoris 369.49 10.45 1071 629242 50661 79063414
Muscular weakness 363.06 10.45 2344 627969 158385 78955690
Helicobacter infection 330.59 10.45 73 630240 69631 79044444
Alopecia 319.11 10.45 862 629451 230493 78883582
Product use issue 317.93 10.45 745 629568 209077 78904998
Stomatitis 288.09 10.45 446 629867 146311 78967764
Hypomagnesaemia 287.98 10.45 921 629392 45990 79068085
Wound 285.23 10.45 298 630015 115881 78998194
Hyperkalaemia 277.95 10.45 1700 628613 112698 79001377
Folliculitis 275.07 10.45 52 630261 55328 79058747
Atrial fibrillation 270.14 10.45 2568 627745 195318 78918757
Discomfort 270.02 10.45 358 629955 125259 78988816
Hypersensitivity 267.17 10.45 1115 629198 261124 78852951
Sleep disorder due to general medical condition, insomnia type 261.85 10.45 22 630291 43534 79070541
Syncope 253.55 10.45 2346 627967 177103 78936972
Joint swelling 252.19 10.45 1298 629015 287348 78826727
Polymyositis 248.10 10.45 200 630113 2836 79111239
Lactic acidosis 246.28 10.45 1156 629157 69203 79044872
Chest pain 245.25 10.45 3354 626959 278950 78835125
Irritable bowel syndrome 244.17 10.45 93 630220 62148 79051927
Swelling 244.04 10.45 885 629428 215826 78898249
Coronary artery stenosis 240.61 10.45 387 629926 12097 79101978
Rheumatoid arthritis 236.96 10.45 848 629465 207622 78906453
Fall 230.49 10.45 5257 625056 482372 78631703
Infection 223.71 10.45 1065 629248 240647 78873428
Impaired healing 222.95 10.45 218 630095 87437 79026638
Neutropenia 220.79 10.45 1350 628963 286360 78827715
Angina unstable 218.99 10.45 435 629878 16092 79097983
Hypoglycaemia 215.57 10.45 1459 628854 100135 79013940
Pyrexia 214.25 10.45 3927 626386 674782 78439293
Coronary artery occlusion 208.86 10.45 408 629905 14907 79099168
Transient ischaemic attack 206.29 10.45 895 629418 51800 79062275
Drug hypersensitivity 206.21 10.45 3414 626899 295502 78818573
Ischaemic stroke 202.01 10.45 649 629664 32482 79081593
Product use in unapproved indication 201.99 10.45 1156 629157 249203 78864872
Cardiac failure 201.69 10.45 1990 628323 152852 78961223
Intentional product use issue 197.64 10.45 583 629730 151529 78962546
Sinusitis 194.87 10.45 838 629475 194663 78919412
Bradycardia 194.35 10.45 1778 628535 133779 78980296
Cholestasis 193.35 10.45 871 629442 51238 79062837
Autoimmune myositis 192.62 10.45 77 630236 226 79113849
Acute coronary syndrome 189.58 10.45 476 629837 20657 79093418
Melaena 189.19 10.45 967 629346 59923 79054152
Diabetic ketoacidosis 184.59 10.45 642 629671 33480 79080595
Muscle spasms 182.69 10.45 2149 628164 172581 78941494
Dizziness 177.10 10.45 5428 624885 521013 78593062
Rectal haemorrhage 173.52 10.45 1115 629198 75185 79038890
Blood glucose increased 173.49 10.45 1525 628788 113450 79000625
Product monitoring error 171.52 10.45 276 630037 8630 79105445
Gastrointestinal haemorrhage 168.49 10.45 1848 628465 145871 78968204
Labelled drug-drug interaction medication error 167.09 10.45 540 629773 27110 79086965
Asthenia 166.03 10.45 5253 625060 506436 78607639
Abdominal discomfort 166.02 10.45 1229 629084 249498 78864577
Pain 165.08 10.45 4269 626044 699533 78414542
Musculoskeletal stiffness 163.09 10.45 769 629544 174239 78939836
Rheumatic fever 162 10.45 18 630295 28507 79085568
Pregnancy 160.21 10.45 14 630299 26837 79087238
Dyspnoea 158.23 10.45 8281 622032 848744 78265331
Myositis 157.77 10.45 418 629895 18750 79095325
Drug resistance 155.97 10.45 69 630244 42144 79071931
Fibromyalgia 152.36 10.45 170 630143 64170 79049905
Autoimmune hepatitis 152.36 10.45 307 630006 11476 79102599
Condition aggravated 152.12 10.45 2918 627395 498206 78615869
Glycosylated haemoglobin increased 151.47 10.45 413 629900 18847 79095228
Haematuria 150.47 10.45 996 629317 67840 79046235
Low density lipoprotein increased 149.66 10.45 255 630058 8367 79105708
Cardiac failure congestive 149.09 10.45 1752 628561 140650 78973425
Myelosuppression 145.56 10.45 68 630245 40228 79073847
Swollen joint count increased 145.22 10.45 9 630304 22918 79091157
Muscle injury 144.09 10.45 104 630209 48457 79065618
Mitral valve incompetence 140.50 10.45 521 629792 28044 79086031
Cerebral haemorrhage 139.97 10.45 857 629456 56816 79057259
Hepatitis cholestatic 139.22 10.45 326 629987 13526 79100549
Ill-defined disorder 138.22 10.45 191 630122 65684 79048391
Hypertensive emergency 135.51 10.45 137 630176 2648 79111427
Myocardial ischaemia 134.46 10.45 476 629837 25043 79089032
Haematochezia 133.50 10.45 1165 629148 86480 79027595
Device expulsion 133.40 10.45 22 630291 25839 79088236
Cytomegalovirus infection 132.29 10.45 87 630226 42557 79071518
Erectile dysfunction 130.18 10.45 329 629984 14335 79099740
Hepatocellular injury 129.59 10.45 729 629584 46864 79067211
Mucosal inflammation 128.84 10.45 251 630062 75329 79038746
Product prescribing error 127.07 10.45 694 629619 44119 79069956
Blister 125.93 10.45 501 629812 118975 78995100
Psoriatic arthropathy 125.34 10.45 268 630045 77731 79036344
Intentional overdose 125.04 10.45 424 629889 105536 79008539
Mixed liver injury 124.84 10.45 219 630094 7359 79106716
Liver function test abnormal 122.74 10.45 902 629411 63573 79050502
Hyponatraemia 122.39 10.45 2031 628282 175817 78938258
Malignant neoplasm progression 121.77 10.45 606 629707 135384 78978691
Intentional self-injury 121.34 10.45 52 630261 32367 79081708
Upper gastrointestinal haemorrhage 120.83 10.45 646 629667 40734 79073341
Renal failure 119.74 10.45 2243 628070 198725 78915350
Respiratory depression 119.34 10.45 35 630278 27595 79086480
Premature delivery 118.76 10.45 21 630292 23446 79090629
Hepatic enzyme increased 118.50 10.45 900 629413 181710 78932365
Nasopharyngitis 117.99 10.45 1360 628953 252521 78861554
Abortion spontaneous 115.87 10.45 44 630269 29463 79084612
Anaemia 114.64 10.45 4450 625863 440565 78673510
Pancreatitis acute 114.06 10.45 727 629586 48877 79065198
Blood triglycerides increased 113.92 10.45 396 629917 20644 79093431
Renal impairment 111.94 10.45 1811 628502 155972 78958103
Rash 111.93 10.45 3601 626712 574757 78539318
C-reactive protein increased 108.75 10.45 587 629726 128440 78985635
Hepatic cytolysis 106.13 10.45 461 629852 26690 79087385
Chromaturia 105.94 10.45 444 629869 25302 79088773
Oedema peripheral 105.55 10.45 2676 627637 249612 78864463
High density lipoprotein decreased 104.71 10.45 155 630158 4500 79109575
C-reactive protein abnormal 103.73 10.45 138 630175 48229 79065846
Ischaemic cardiomyopathy 103.71 10.45 204 630109 7491 79106584
Gastrointestinal disorder 102.42 10.45 557 629756 121648 78992427
Cardiac disorder 101.66 10.45 877 629436 64880 79049195
Hip arthroplasty 100.43 10.45 81 630232 35675 79078400
Neurologic neglect syndrome 99.69 10.45 119 630194 2788 79111287
Diabetes mellitus inadequate control 98.71 10.45 417 629896 23847 79090228
Myocardial necrosis marker increased 98.60 10.45 125 630188 3121 79110954
Carotid artery thrombosis 98.22 10.45 121 630192 2932 79111143
Neutrophil count decreased 97.75 10.45 396 629917 93563 79020512
Cardiac failure chronic 96.95 10.45 248 630065 10887 79103188
Haematoma 96.39 10.45 725 629588 51470 79062605
Bone marrow failure 95.82 10.45 160 630153 50947 79063128
Muscle rupture 95.44 10.45 132 630181 3595 79110480
Neurotoxicity 94.71 10.45 71 630242 32447 79081628
Knee arthroplasty 94.18 10.45 122 630191 43126 79070949
Presyncope 93.35 10.45 600 629713 40454 79073621
Vascular stent thrombosis 92.92 10.45 130 630183 3580 79110495
Glomerular filtration rate decreased 91.46 10.45 389 629924 22313 79091762
Hypocalcaemia 90.81 10.45 691 629622 49233 79064842
Muscle necrosis 90.43 10.45 82 630231 1376 79112699
Suicide attempt 90.43 10.45 343 629970 82589 79031486
Dyspnoea exertional 88.76 10.45 1066 629247 86007 79028068
Hypotension 88.15 10.45 4290 626023 436027 78678048
Carotid artery stenosis 87.89 10.45 206 630107 8552 79105523
Pancytopenia 87.84 10.45 861 629452 164884 78949191
Arteriosclerosis 87.60 10.45 330 629983 17897 79096178
Hepatitis acute 87.18 10.45 296 630017 15246 79098829
Myopathy toxic 86.91 10.45 71 630242 1027 79113048
Injection site erythema 86.84 10.45 321 629992 77876 79036199
Caesarean section 85.59 10.45 3 630310 12532 79101543
Leukopenia 84.98 10.45 555 629758 115958 78998117
Poisoning 84.77 10.45 47 630266 25225 79088850
Troponin increased 83.91 10.45 338 629975 18917 79095158
White blood cell count decreased 83.83 10.45 1018 629295 187270 78926805
Chronic kidney disease 83.06 10.45 844 629469 65310 79048765
Faeces discoloured 82.52 10.45 451 629862 28676 79085399
Polymyalgia rheumatica 82.49 10.45 137 630176 4400 79109675
Red blood cell sedimentation rate abnormal 81.09 10.45 32 630281 20931 79093144
Respiratory arrest 80.32 10.45 213 630100 57337 79056738
Haemophagocytic lymphohistiocytosis 80.19 10.45 36 630277 21801 79092274
Blood loss anaemia 79.87 10.45 287 630026 15211 79098864
Graft versus host disease 79.27 10.45 12 630301 15014 79099061
Therapeutic product effect incomplete 78.80 10.45 727 629586 140918 78973157
Myoglobin blood increased 78.30 10.45 110 630203 3041 79111034
Drug ineffective for unapproved indication 78.26 10.45 181 630132 51057 79063018
Drug-induced liver injury 78.04 10.45 833 629480 65284 79048791
Therapeutic response decreased 76.51 10.45 271 630042 66582 79047493
International normalised ratio increased 76.46 10.45 1014 629299 83707 79030368
Rheumatoid nodule 75.47 10.45 22 630291 17416 79096659
Mobility decreased 75.11 10.45 611 629702 121564 78992511
Disease progression 74.95 10.45 1016 629297 183346 78930729
Chronic obstructive pulmonary disease 74.88 10.45 1017 629296 84402 79029673
Ascites 73.94 10.45 326 629987 75236 79038839
Hemiplegia 73.90 10.45 273 630040 14666 79099409
Inferior vena cava dilatation 72.49 10.45 58 630255 813 79113262
Electrocardiogram abnormal 72.30 10.45 293 630020 16444 79097631
Haemorrhage intracranial 71.82 10.45 402 629911 25791 79088284
Cerebral infarction 71.55 10.45 611 629702 45065 79069010
Lower respiratory tract infection 71.54 10.45 664 629649 128556 78985519
Platelet count decreased 71.00 10.45 1096 629217 193568 78920507
Atrioventricular block complete 70.34 10.45 289 630024 16321 79097754
Product substitution issue 70.26 10.45 332 629981 19924 79094151
Bronchopulmonary aspergillosis 69.80 10.45 45 630268 22249 79091826
Hemiparesis 69.46 10.45 481 629832 33252 79080823
Inflammation 69.17 10.45 445 629868 93308 79020767
Tendon rupture 68.95 10.45 232 630081 11894 79102181
Injection site reaction 68.94 10.45 213 630100 54572 79059503
Jaundice 68.59 10.45 684 629629 52665 79061410
Arteriosclerosis coronary artery 68.49 10.45 301 630012 17515 79096560
Pathogen resistance 68.03 10.45 15 630298 14327 79099748
Red blood cell sedimentation rate increased 68.01 10.45 165 630148 45777 79068298
Pneumocystis jirovecii pneumonia 67.45 10.45 95 630218 32413 79081662
Loss of personal independence in daily activities 67.25 10.45 504 629809 102076 79011999
Subdural haematoma 66.97 10.45 452 629861 30982 79083093
Diabetes mellitus 66.14 10.45 927 629386 77463 79036612
Cholestatic liver injury 65.40 10.45 130 630183 4811 79109264
N-terminal prohormone brain natriuretic peptide increased 65.23 10.45 127 630186 4628 79109447
Vascular stent stenosis 65.12 10.45 70 630243 1457 79112618
Dysarthria 65.08 10.45 819 629494 66803 79047272
Panniculitis 64.99 10.45 10 630303 12361 79101714
Breast cancer stage III 64.91 10.45 3 630310 9823 79104252
Epstein-Barr virus infection 64.61 10.45 17 630296 14399 79099676
Muscle atrophy 63.96 10.45 215 630098 11017 79103058
Blood creatine phosphokinase MB increased 63.81 10.45 94 630219 2717 79111358
Aspergillus infection 63.74 10.45 36 630277 19125 79094950
Atrioventricular block 63.21 10.45 249 630064 13792 79100283
Bone erosion 63.10 10.45 31 630282 17816 79096259
Dermatomyositis 62.68 10.45 107 630206 3516 79110559
Urinary retention 62.47 10.45 704 629609 55926 79058149
Incorrect route of product administration 62.16 10.45 113 630200 34816 79079259
Injection site pain 62.03 10.45 691 629622 129147 78984928
Hyperglycaemia 61.88 10.45 838 629475 69497 79044578
Intentional product misuse 61.71 10.45 469 629844 94696 79019379
Cytokine release syndrome 60.09 10.45 121 630192 35877 79078198
Pemphigoid 59.06 10.45 259 630054 15056 79099019
Coma 58.86 10.45 510 629803 100139 79013936
Drug tolerance decreased 58.75 10.45 15 630298 12963 79101112
Eosinophilia 58.11 10.45 581 629732 44764 79069311
Arthralgia 58.08 10.45 3817 626496 567986 78546089
Dehydration 57.81 10.45 2456 627857 245731 78868344
Sedation 57.63 10.45 213 630100 51682 79062393
Ejection fraction decreased 57.60 10.45 469 629844 34108 79079967
Swollen tongue 57.27 10.45 551 629762 42019 79072056
Low density lipoprotein abnormal 57.25 10.45 39 630274 420 79113655
Coronary artery restenosis 56.81 10.45 61 630252 1268 79112807
Personality disorder 56.77 10.45 140 630173 6006 79108069
Acute myeloid leukaemia 56.69 10.45 98 630215 30787 79083288
Haematotoxicity 56.34 10.45 26 630287 15493 79098582
Adjustment disorder 56.29 10.45 108 630205 3892 79110183
Low density lipoprotein decreased 55.67 10.45 58 630255 1163 79112912
Haemorrhagic stroke 55.60 10.45 203 630110 10843 79103232
Adverse drug reaction 54.85 10.45 304 630009 66088 79047987
Therapy partial responder 54.63 10.45 35 630278 17362 79096713
Adenovirus infection 54.46 10.45 3 630310 8444 79105631
Haematemesis 54.20 10.45 642 629671 51622 79062453
Multiple-drug resistance 54.20 10.45 4 630309 8804 79105271
Premature labour 54.03 10.45 3 630310 8387 79105688
Migraine 54.02 10.45 437 629876 87056 79027019
Appendicitis 53.69 10.45 51 630262 20743 79093332
Transplant rejection 53.39 10.45 45 630268 19392 79094683
Drug use disorder 53.03 10.45 4 630309 8647 79105428
Large intestine polyp 52.94 10.45 220 630093 12488 79101587
Weight decreased 52.62 10.45 3367 626946 351831 78762244
Serotonin syndrome 52.54 10.45 181 630132 44846 79069229
Dysuria 52.45 10.45 625 629688 50326 79063749
Orthostatic hypotension 52.25 10.45 676 629637 55488 79058587
Immune reconstitution inflammatory syndrome 52.12 10.45 22 630291 13819 79100256
Therapeutic drug monitoring analysis not performed 51.74 10.45 70 630243 1866 79112209
Coronary artery bypass 51.73 10.45 134 630179 5928 79108147
Cardiac failure acute 51.55 10.45 290 630023 18639 79095436
Hyperlipidaemia 51.35 10.45 368 629945 25725 79088350
Haemorrhagic transformation stroke 51.26 10.45 83 630230 2609 79111466
Overdose 51.12 10.45 1088 629225 183118 78930957
Nocturia 50.97 10.45 229 630084 13452 79100623
Injection site swelling 50.69 10.45 196 630117 46936 79067139
Muscle disorder 50.61 10.45 128 630185 5579 79108496
Post transplant lymphoproliferative disorder 50.47 10.45 14 630299 11450 79102625
Angioedema 49.95 10.45 862 629451 75173 79038902
Tricuspid valve incompetence 49.78 10.45 296 630017 19416 79094659
Enthesopathy 49.59 10.45 15 630298 11593 79102482
Grip strength decreased 49.38 10.45 60 630253 21809 79092266
Venoocclusive liver disease 48.88 10.45 16 630297 11755 79102320
Type V hyperlipidaemia 48.37 10.45 50 630263 993 79113082
Blood glucose decreased 48.20 10.45 364 629949 25870 79088205
Progressive multifocal leukoencephalopathy 48.14 10.45 55 630258 20545 79093530
Blood pressure increased 47.96 10.45 2086 628227 209274 78904801
Immunodeficiency 47.81 10.45 61 630252 21707 79092368
Sickle cell anaemia with crisis 47.62 10.45 4 630309 7918 79106157
Joint range of motion decreased 47.34 10.45 122 630191 33160 79080915
Euglycaemic diabetic ketoacidosis 47.23 10.45 140 630173 6704 79107371
Hepatitis 47.00 10.45 659 629654 55068 79059007
Cardiotoxicity 46.82 10.45 19 630294 12220 79101855
Aphasia 46.69 10.45 570 629743 46162 79067913
Urinary tract discomfort 46.60 10.45 42 630271 699 79113376
Breast cancer stage II 46.42 10.45 5 630308 8115 79105960
Adjustment disorder with depressed mood 46.26 10.45 8 630305 9078 79104997
Ocular myasthenia 46.19 10.45 32 630281 355 79113720
Atrial flutter 46.09 10.45 311 630002 21314 79092761
Injection site pruritus 46.01 10.45 175 630138 42108 79071967
Lymphocyte count decreased 45.67 10.45 205 630108 47084 79066991
Peripheral arterial occlusive disease 45.20 10.45 156 630157 8102 79105973
Shock haemorrhagic 44.88 10.45 292 630021 19768 79094307
Systemic infection 44.76 10.45 174 630139 9578 79104497
Sensory loss 44.38 10.45 212 630101 12779 79101296
Idiopathic pulmonary fibrosis 44.13 10.45 101 630212 4127 79109948
Tumour lysis syndrome 43.90 10.45 76 630237 23863 79090212
Adverse event 43.80 10.45 287 630026 59927 79054148
Alveolar osteitis 43.76 10.45 43 630270 802 79113273
Accidental exposure to product 43.65 10.45 116 630197 31206 79082869
Computerised tomogram coronary artery abnormal 43.59 10.45 25 630288 193 79113882
Unintentional medical device removal 43.46 10.45 5 630308 7707 79106368
Cerebral haematoma 43.44 10.45 150 630163 7792 79106283
Arterial occlusive disease 43.07 10.45 156 630157 8300 79105775
Disability 43.03 10.45 43 630270 17077 79096998
Cardio-respiratory arrest 43.00 10.45 601 629712 107909 79006166
Pain in extremity 42.34 10.45 3388 626925 361150 78752925
Confusional state 42.04 10.45 2986 627327 315011 78799064
Diabetic nephropathy 42.00 10.45 80 630233 2867 79111208
Muscle discomfort 41.97 10.45 27 630286 262 79113813
Device dislocation 41.91 10.45 89 630224 25881 79088194
Exercise tolerance decreased 41.76 10.45 162 630151 8909 79105166
Aplastic anaemia 41.63 10.45 48 630265 17857 79096218
Hypertensive crisis 41.49 10.45 294 630019 20476 79093599
Device adhesion issue 41.37 10.45 4 630309 7071 79107004
Ventricular hypokinesia 41.32 10.45 164 630149 9115 79104960
Foetal death 41.14 10.45 7 630306 8037 79106038
Pre-eclampsia 41.12 10.45 4 630309 7037 79107038
Muscle enzyme increased 40.99 10.45 31 630282 398 79113677
Left atrial enlargement 40.85 10.45 49 630264 1154 79112921
Tunnel vision 40.58 10.45 56 630257 1522 79112553
Disseminated intravascular coagulation 40.53 10.45 146 630167 35696 79078379
Neoplasm progression 40.35 10.45 241 630072 51441 79062634
Dislocation of vertebra 39.99 10.45 7 630306 7873 79106202
Candida infection 39.77 10.45 161 630152 38053 79076022
Lichen planopilaris 39.65 10.45 15 630298 36 79114039
Blood cholesterol decreased 39.61 10.45 58 630255 1667 79112408
Pollakiuria 39.40 10.45 460 629853 36857 79077218
Urinary tract obstruction 39.30 10.45 104 630209 4661 79109414
Hypokalaemia 39.02 10.45 1449 628864 142591 78971484
Exercise lack of 38.99 10.45 32 630281 466 79113609
Arterial stenosis 38.50 10.45 52 630261 1384 79112691
Cardiomyopathy 38.49 10.45 372 629941 28402 79085673
Epistaxis 38.43 10.45 1154 629159 110361 79003714
Microcytic anaemia 38.42 10.45 110 630203 5164 79108911
Pancreatitis 38.27 10.45 758 629555 67817 79046258
Mydriasis 38.17 10.45 50 630263 17593 79096482
Dementia 38.16 10.45 329 629984 24330 79089745
Tenosynovitis 38.03 10.45 40 630273 15514 79098561
Weight increased 37.96 10.45 1798 628515 275588 78838487
Cardiac aneurysm 37.73 10.45 53 630260 1465 79112610
Blood parathyroid hormone decreased 37.71 10.45 18 630295 10518 79103557
Peripheral artery stenosis 37.49 10.45 49 630264 1262 79112813
Intermittent claudication 37.43 10.45 84 630229 3387 79110688
Fungal infection 37.37 10.45 186 630127 41562 79072513
Paradoxical drug reaction 37.31 10.45 6 630307 7179 79106896
Device related infection 37.27 10.45 142 630171 34152 79079923
Duodenal ulcer 37.06 10.45 239 630074 16130 79097945
Ventricular hypertrophy 37.05 10.45 130 630183 6808 79107267
Gamma-glutamyltransferase increased 37.03 10.45 623 629690 54057 79060018
Sepsis 36.95 10.45 1746 628567 267682 78846393
Psychotic disorder 36.75 10.45 185 630128 41217 79072858
Myelodysplastic syndrome 36.59 10.45 120 630193 30181 79083894
Dermatitis atopic 36.48 10.45 167 630146 9889 79104186
Electrolyte imbalance 36.40 10.45 389 629924 30492 79083583
Blood cholesterol abnormal 36.05 10.45 81 630232 3269 79110806
Blood iron decreased 35.97 10.45 227 630086 15207 79098868
Spur cell anaemia 35.79 10.45 18 630295 103 79113972
Uterine perforation 35.73 10.45 4 630309 6299 79107776
Joint destruction 35.59 10.45 3 630310 5922 79108153
Urticaria 35.47 10.45 1154 629159 184047 78930028
Arrhythmia 35.45 10.45 681 629632 60591 79053484
Aortic stenosis 35.44 10.45 135 630178 7360 79106715
Lip swelling 35.39 10.45 486 629827 40425 79073650
Posterior reversible encephalopathy syndrome 35.37 10.45 99 630214 26182 79087893
Ventricular internal diameter abnormal 35.26 10.45 23 630290 229 79113846
Therapy non-responder 35.25 10.45 515 629798 91790 79022285
Food allergy 35.06 10.45 21 630292 10803 79103272
Chest discomfort 34.85 10.45 1378 628935 136666 78977409
Cytomegalovirus viraemia 34.83 10.45 30 630283 12791 79101284
Nipple swelling 34.73 10.45 25 630288 296 79113779
Febrile bone marrow aplasia 34.72 10.45 31 630282 12989 79101086
Hypertransaminasaemia 34.70 10.45 186 630127 11738 79102337
Pneumonia 34.69 10.45 4631 625682 655615 78458460
Abortion induced 34.61 10.45 7 630306 7102 79106973
Amyotrophic lateral sclerosis 34.61 10.45 56 630257 1759 79112316
Sinus bradycardia 34.56 10.45 328 629985 24919 79089156
Amnesia 34.52 10.45 695 629618 62362 79051713
Flatulence 34.34 10.45 501 629812 42223 79071852
Sedation complication 34.32 10.45 44 630269 15625 79098450
Scrotal pain 34.25 10.45 31 630282 519 79113556
Rales 34.24 10.45 273 630040 19728 79094347
Peripheral vascular disorder 34.23 10.45 140 630173 7890 79106185
Cytomegalovirus infection reactivation 34.22 10.45 13 630300 8703 79105372
Diabetic metabolic decompensation 34.12 10.45 79 630234 3253 79110822
Dystonia 33.98 10.45 74 630239 21325 79092750
Motor dysfunction 33.90 10.45 216 630097 14517 79099558
Cystitis haemorrhagic 33.87 10.45 15 630298 9157 79104918
Multiple sclerosis relapse 33.74 10.45 222 630091 46311 79067764
Head injury 33.59 10.45 447 629866 36922 79077153
Retinitis 33.51 10.45 3 630310 5640 79108435
Pallor 33.40 10.45 569 629744 49493 79064582
Hypovolaemic shock 33.38 10.45 188 630125 12088 79101987
Enterococcal infection 33.25 10.45 45 630268 15615 79098460
Gait disturbance 33.09 10.45 1980 628333 205526 78908549
Eating disorder 33.01 10.45 278 630035 20419 79093656
Eructation 33.00 10.45 172 630141 10737 79103338
Stent placement 32.97 10.45 120 630193 6400 79107675
Amenorrhoea 32.75 10.45 10 630303 7682 79106393
Ketoacidosis 32.74 10.45 136 630177 7718 79106357
Blood urea abnormal 32.49 10.45 46 630267 1281 79112794
Basal ganglia haemorrhage 32.47 10.45 52 630261 1619 79112456
Affect lability 32.34 10.45 175 630138 11084 79102991
Ear infection 32.21 10.45 151 630162 34281 79079794
Cardiac murmur 32.20 10.45 225 630088 15599 79098476
X-ray abnormal 32.18 10.45 4 630309 5809 79108266
Gout 32.14 10.45 318 629995 24431 79089644
Lip dry 32.04 10.45 45 630268 15373 79098702
Bacteraemia 31.87 10.45 142 630171 32682 79081393
Breast cancer stage I 31.79 10.45 7 630306 6693 79107382
Incorrect dosage administered 31.61 10.45 69 630244 2730 79111345
Human herpesvirus 6 infection 31.50 10.45 3 630310 5367 79108708
Mouth swelling 31.13 10.45 112 630201 5939 79108136
Headache 31.12 10.45 4613 625700 649159 78464916
Subarachnoid haemorrhage 31.12 10.45 313 630000 24152 79089923
Drug dependence 30.84 10.45 192 630121 40577 79073498
Labile blood pressure 30.69 10.45 60 630253 2193 79111882
Heart rate irregular 30.67 10.45 394 629919 32285 79081790
Substance abuse 30.63 10.45 23 630290 10503 79103572
Degenerative mitral valve disease 30.63 10.45 23 630290 292 79113783
Vertigo 30.39 10.45 738 629575 68344 79045731
Anti-neutrophil cytoplasmic antibody positive vasculitis 30.36 10.45 81 630232 3648 79110427
Abnormal loss of weight 30.31 10.45 139 630174 8237 79105838
Polyuria 30.27 10.45 213 630100 14801 79099274
Blood creatinine increased 30.15 10.45 1507 628806 153550 78960525
Temperature regulation disorder 30.14 10.45 5 630308 5848 79108227
Ageusia 30.12 10.45 230 630083 16402 79097673
Exposure via ingestion 30.06 10.45 3 630310 5171 79108904
Intraventricular haemorrhage 30.03 10.45 96 630217 4791 79109284
Hepatitis toxic 29.73 10.45 99 630214 5048 79109027
Maternal exposure timing unspecified 29.71 10.45 5 630308 5787 79108288
Aortic aneurysm 29.70 10.45 139 630174 8307 79105768
Diabetic foot 29.68 10.45 79 630234 3553 79110522
Acute respiratory distress syndrome 29.60 10.45 215 630098 43852 79070223
Thrombocytopenia 29.40 10.45 1756 628557 263503 78850572
Dyspnoea at rest 29.32 10.45 125 630188 7177 79106898
Cardiac valve disease 29.31 10.45 106 630207 5635 79108440
Carotid artery disease 29.28 10.45 59 630254 2205 79111870
Pulmonary vascular disorder 29.27 10.45 39 630274 1024 79113051
Nocardiosis 28.92 10.45 5 630308 5674 79108401
Palmar-plantar erythrodysaesthesia syndrome 28.87 10.45 149 630164 32985 79081090
Prostatomegaly 28.71 10.45 76 630237 3407 79110668
C-reactive protein 28.63 10.45 3 630310 4976 79109099
Blood creatine phosphokinase abnormal 28.59 10.45 26 630287 438 79113637
Ear congestion 28.57 10.45 68 630245 2851 79111224
Ventricular enlargement 28.52 10.45 32 630281 700 79113375
Atrioventricular block second degree 28.46 10.45 124 630189 7188 79106887
Quadriparesis 28.46 10.45 76 630237 3425 79110650
Rectal polyp 28.32 10.45 49 630264 1628 79112447
Gynaecomastia 28.19 10.45 128 630185 7553 79106522
Lower gastrointestinal haemorrhage 28.10 10.45 221 630092 15904 79098171
Injection site warmth 28.08 10.45 46 630267 14761 79099314
Vascular device infection 27.97 10.45 24 630289 10252 79103823
Lacunar infarction 27.92 10.45 107 630206 5850 79108225
Diabetic retinopathy 27.90 10.45 70 630243 3036 79111039
Drug tolerance 27.86 10.45 17 630296 8658 79105417
Pneumatosis intestinalis 27.81 10.45 8 630305 6389 79107686
Diabetic neuropathy 27.79 10.45 110 630203 6106 79107969
Device issue 27.71 10.45 115 630198 26993 79087082
Peripheral artery occlusion 27.71 10.45 62 630251 2495 79111580
Facet joint syndrome 27.71 10.45 29 630284 11273 79102802
Colorectal cancer 27.70 10.45 17 630296 8630 79105445
Hypoacusis 27.66 10.45 362 629951 29788 79084287
Multiple organ dysfunction syndrome 27.58 10.45 731 629582 119515 78994560
Complication of device insertion 27.50 10.45 8 630305 6342 79107733
Pericardial haemorrhage 27.35 10.45 88 630225 4407 79109668
Sinus node dysfunction 27.28 10.45 127 630186 7574 79106501
Tuberculosis 27.19 10.45 49 630264 15149 79098926
Heavy menstrual bleeding 27.07 10.45 43 630270 13968 79100107
Juvenile idiopathic arthritis 27.06 10.45 3 630310 4760 79109315
Ventricular tachycardia 27.03 10.45 474 629839 41461 79072614
Coeliac disease 26.86 10.45 30 630283 11321 79102754
Interstitial lung disease 26.80 10.45 1117 629196 111483 79002592
Creatinine renal clearance decreased 26.76 10.45 70 630243 18932 79095143
Inappropriate antidiuretic hormone secretion 26.74 10.45 322 629991 25991 79088084
Subacute cutaneous lupus erythematosus 26.65 10.45 75 630238 3486 79110589
Oropharyngeal pain 26.63 10.45 659 629654 108694 79005381
Central obesity 26.59 10.45 49 630264 1712 79112363
Anuria 26.57 10.45 268 630045 20695 79093380
Oesophageal carcinoma 26.55 10.45 29 630284 11055 79103020
Oral herpes 26.52 10.45 119 630194 27335 79086740
Balance disorder 26.41 10.45 993 629320 97864 79016211
Flushing 26.36 10.45 515 629798 87753 79026322
Pulmonary valve incompetence 26.00 10.45 51 630262 1869 79112206
Angiopathy 25.98 10.45 118 630195 6964 79107111
Lower limb fracture 25.96 10.45 95 630218 23120 79090955
Skin necrosis 25.95 10.45 66 630247 18021 79096054
Diverticulum 25.87 10.45 204 630109 14692 79099383
Onychomadesis 25.86 10.45 5 630308 5237 79108838
Dyslipidaemia 25.82 10.45 169 630144 11464 79102611
Injury 25.69 10.45 444 629869 77052 79037023
Foetal exposure during pregnancy 25.62 10.45 7 630306 5783 79108292
Gastritis erosive 25.56 10.45 160 630153 10687 79103388
Palpitations 25.54 10.45 1235 629078 125375 78988700
Nipple pain 25.54 10.45 34 630279 892 79113183
Circulatory collapse 25.44 10.45 429 629884 37239 79076836
Stenosis 25.44 10.45 58 630255 2364 79111711
Seizure 25.42 10.45 1226 629087 187608 78926467
Psoriasis 25.42 10.45 906 629407 88681 79025394
Bacterial infection 25.41 10.45 144 630169 31136 79082939
Genital swelling 25.41 10.45 21 630292 309 79113766
Penile haemorrhage 25.37 10.45 26 630287 511 79113564
Polyp 25.34 10.45 129 630184 7978 79106097
Retinal artery occlusion 25.27 10.45 70 630243 3224 79110851
Ovarian cyst 25.25 10.45 38 630275 12617 79101458
Cytopenia 25.11 10.45 80 630233 20303 79093772
Neutropenic colitis 25.07 10.45 7 630306 5700 79108375
Carotid arteriosclerosis 25.06 10.45 61 630252 2595 79111480
Cell death 25.05 10.45 88 630225 4611 79109464
Wound infection 25.01 10.45 101 630212 23890 79090185
Bursitis 24.99 10.45 173 630140 35671 79078404
Erythema 24.94 10.45 1477 628836 221813 78892262
Vascular purpura 24.93 10.45 67 630246 3031 79111044
Bundle branch block left 24.79 10.45 166 630147 11347 79102728
Hypogammaglobulinaemia 24.78 10.45 40 630273 12911 79101164
Disorientation 24.78 10.45 661 629652 62115 79051960
Orthopnoea 24.63 10.45 150 630163 9923 79104152
Essential hypertension 24.60 10.45 104 630209 5949 79108126
Blood electrolytes abnormal 24.54 10.45 50 630263 1884 79112191
Status epilepticus 24.51 10.45 108 630205 24933 79089142
Depressed level of consciousness 24.48 10.45 579 629734 96073 79018002
Menstruation irregular 24.43 10.45 5 630308 5031 79109044
Acne 24.41 10.45 121 630192 27069 79087006
Acute lymphocytic leukaemia recurrent 24.41 10.45 4 630309 4720 79109355
Agitated depression 24.33 10.45 23 630290 408 79113667
Urosepsis 24.26 10.45 318 629995 26177 79087898
Maternal exposure before pregnancy 24.23 10.45 3 630310 4370 79109705
Tongue oedema 24.21 10.45 116 630197 7001 79107074
Left atrial dilatation 24.18 10.45 67 630246 3086 79110989
Hepatitis B reactivation 24.16 10.45 9 630304 6099 79107976
Vascular stent occlusion 24.13 10.45 18 630295 226 79113849
Gastric ulcer 23.95 10.45 389 629924 33516 79080559
Blood creatine increased 23.89 10.45 142 630171 9313 79104762
Muscle haemorrhage 23.88 10.45 106 630207 6194 79107881
Calculus urinary 23.75 10.45 57 630256 2403 79111672
Gastritis 23.68 10.45 521 629792 47472 79066603
Drug withdrawal syndrome 23.50 10.45 169 630144 34549 79079526
Aldolase increased 23.49 10.45 18 630295 236 79113839
Prescribed overdose 23.48 10.45 189 630124 37694 79076381
Herpes zoster 23.47 10.45 558 629755 92525 79021550
Neuroleptic malignant syndrome 23.41 10.45 125 630188 27434 79086641
Staphylococcal infection 23.40 10.45 322 629991 57973 79056102
Aortic valve incompetence 23.36 10.45 142 630171 9388 79104687
Blood sodium decreased 23.29 10.45 381 629932 32874 79081201
Macroglossia 23.29 10.45 37 630276 1144 79112931
Bradyarrhythmia 23.29 10.45 79 630234 4067 79110008
Device difficult to use 23.20 10.45 44 630269 13341 79100734
Hepatic encephalopathy 23.19 10.45 105 630208 24061 79090014
Blood pressure fluctuation 23.13 10.45 382 629931 66763 79047312
Virologic failure 22.92 10.45 3 630310 4188 79109887
Myoglobinaemia 22.92 10.45 14 630299 123 79113952
Crying 22.79 10.45 99 630214 22944 79091131
Akathisia 22.62 10.45 44 630269 13215 79100860
Penis injury 22.54 10.45 14 630299 127 79113948
Benign prostatic hyperplasia 22.40 10.45 163 630150 11449 79102626
Post viral fatigue syndrome 22.38 10.45 20 630293 329 79113746
Animal scratch 22.24 10.45 41 630272 1433 79112642
Klebsiella infection 22.07 10.45 58 630255 15662 79098413
Clostridium difficile infection 22.06 10.45 223 630090 42462 79071613
Intestinal haemorrhage 22.05 10.45 105 630208 6321 79107754
Blood glucose abnormal 21.95 10.45 151 630162 10415 79103660
Thyroid disorder 21.87 10.45 188 630125 13891 79100184
Dysstasia 21.76 10.45 324 629989 27422 79086653
Atrial thrombosis 21.72 10.45 71 630242 3585 79110490
Aortic valve replacement 21.66 10.45 38 630275 1277 79112798
Lipoprotein (a) increased 21.58 10.45 11 630302 65 79114010
Nodule 21.42 10.45 101 630212 22893 79091182
Drug specific antibody present 21.41 10.45 13 630300 6639 79107436
Aggression 21.35 10.45 279 630034 50679 79063396
Bladder pain 21.34 10.45 53 630260 2284 79111791
Neuropathy peripheral 21.33 10.45 906 629407 140399 78973676
Cold sweat 21.32 10.45 234 630079 18465 79095610
Brain oedema 21.23 10.45 115 630198 25148 79088927
Stillbirth 21.23 10.45 3 630310 3952 79110123
Cardiovascular disorder 21.22 10.45 227 630086 17798 79096277
Acquired claw toe 21.10 10.45 12 630301 91 79113984
Metabolic acidosis 21.09 10.45 825 629488 81704 79032371
International normalised ratio abnormal 21.08 10.45 96 630217 5672 79108403
Metastases to central nervous system 21.07 10.45 63 630250 16312 79097763
Duodenal ulcer haemorrhage 21.02 10.45 112 630201 7051 79107024
Arterial insufficiency 21.01 10.45 20 630293 358 79113717
Cardiogenic shock 20.99 10.45 456 629857 41458 79072617
Upper respiratory tract infection 20.97 10.45 554 629759 90614 79023461
Traumatic coma 20.96 10.45 10 630303 50 79114025
Diffuse large B-cell lymphoma recurrent 20.78 10.45 4 630309 4203 79109872
Peripheral ischaemia 20.75 10.45 137 630176 9320 79104755
Coronary artery surgery 20.67 10.45 15 630298 180 79113895
Metastases to bone 20.64 10.45 111 630202 24316 79089759
Neuromyopathy 20.63 10.45 41 630272 1517 79112558
Adrenal insufficiency 20.60 10.45 136 630177 28351 79085724
Contusion 20.60 10.45 963 629350 147813 78966262
Left ventricular dysfunction 20.59 10.45 239 630074 19122 79094953
Troponin T increased 20.57 10.45 68 630245 3454 79110621
Infarction 20.42 10.45 81 630232 4501 79109574
Gastrointestinal angiodysplasia 20.41 10.45 33 630280 1036 79113039
Penile pain 20.39 10.45 32 630281 979 79113096
Amputation 20.23 10.45 28 630285 763 79113312
Glycosylated haemoglobin abnormal 20.13 10.45 16 630297 222 79113853
Tubulointerstitial nephritis 20.13 10.45 419 629894 37816 79076259
Bronchial secretion retention 20.07 10.45 4 630309 4100 79109975
Carotid artery occlusion 20.06 10.45 116 630197 7531 79106544
Hyperprolactinaemia 20.05 10.45 6 630307 4670 79109405
Pulmonary renal syndrome 20.00 10.45 25 630288 615 79113460
Rhinovirus infection 19.96 10.45 20 630293 7933 79106142
Chest wall haematoma 19.88 10.45 21 630292 428 79113647
Body height decreased 19.87 10.45 126 630187 8454 79105621
Blood urea increased 19.62 10.45 515 629798 48275 79065800
Subdural haemorrhage 19.55 10.45 96 630217 5852 79108223
Immune effector cell-associated neurotoxicity syndrome 19.43 10.45 11 630302 5837 79108238
Suicidal ideation 19.42 10.45 457 629856 75883 79038192
Agitation 19.40 10.45 620 629693 99095 79014980
Renal injury 19.38 10.45 212 630101 16715 79097360
Acquired plagiocephaly 19.36 10.45 7 630306 14 79114061
Fibromatosis colli of infancy 19.36 10.45 7 630306 14 79114061
Intracranial haematoma 19.30 10.45 30 630283 910 79113165
Narrow anterior chamber angle 19.30 10.45 14 630299 168 79113907
Anticoagulation drug level increased 19.28 10.45 27 630286 744 79113331
Infective exacerbation of chronic obstructive airways disease 19.26 10.45 57 630256 2727 79111348
Abnormal weight gain 19.12 10.45 55 630258 2589 79111486
Diverticulum intestinal 19.09 10.45 125 630188 8480 79105595
AST/ALT ratio abnormal 19.04 10.45 7 630306 15 79114060
Occupational problem environmental 18.98 10.45 6 630307 6 79114069
Lecithin-cholesterol acyltransferase deficiency 18.98 10.45 6 630307 6 79114069
Avoidant personality disorder 18.98 10.45 6 630307 6 79114069
Hallucination, gustatory 18.97 10.45 10 630303 64 79114011
Vascular graft occlusion 18.97 10.45 26 630287 702 79113373
Muscle fatigue 18.85 10.45 66 630247 3453 79110622
Embolic stroke 18.80 10.45 116 630197 7710 79106365
Transaminases increased 18.78 10.45 539 629774 51204 79062871
Lacunar stroke 18.72 10.45 19 630294 369 79113706
Deafness 18.64 10.45 251 630062 20786 79093289
Septic shock 18.61 10.45 787 629526 122014 78992061
Cervix neoplasm 18.56 10.45 14 630299 179 79113896
Product complaint 18.56 10.45 174 630139 13175 79100900
Pneumonia cytomegaloviral 18.55 10.45 8 630305 4961 79109114
Blood potassium increased 18.54 10.45 330 629983 28945 79085130
Coordination abnormal 18.54 10.45 214 630099 17098 79096977
Primary biliary cholangitis 18.54 10.45 33 630280 1122 79112953
Fear of injection 18.52 10.45 19 630294 7455 79106620
Cardiac flutter 18.51 10.45 83 630230 4871 79109204
Vascular graft 18.48 10.45 46 630267 1985 79112090
Myoglobinuria 18.39 10.45 32 630281 1068 79113007
Glycogen storage disease type V 18.36 10.45 8 630305 31 79114044
Blood alkaline phosphatase increased 18.34 10.45 645 629668 63019 79051056
Transplant dysfunction 18.31 10.45 18 630295 7203 79106872
Electrocardiogram QT prolonged 18.30 10.45 882 629431 89504 79024571
Injection site haemorrhage 18.23 10.45 137 630176 27733 79086342
Neutropenic sepsis 18.20 10.45 132 630181 26932 79087143
Gastric ulcer haemorrhage 18.16 10.45 128 630185 8899 79105176
Spinal epidural haematoma 18.14 10.45 37 630276 1395 79112680
Drug dispensed to wrong patient 18.07 10.45 25 630288 681 79113394
Deformity 18.07 10.45 30 630283 9575 79104500
Nail disorder 17.99 10.45 42 630271 11810 79102265
Ventricular dyskinesia 17.92 10.45 19 630294 389 79113686
Potassium wasting nephropathy 17.85 10.45 13 630300 157 79113918
Injection site rash 17.84 10.45 77 630236 17877 79096198
ECG signs of myocardial ischaemia 17.80 10.45 18 630295 348 79113727
Occult blood positive 17.79 10.45 104 630209 6779 79107296
Haemorrhage 17.79 10.45 886 629427 90232 79023843
Blood pressure inadequately controlled 17.73 10.45 96 630217 6081 79107994
Obstructive pancreatitis 17.71 10.45 28 630285 862 79113213
Agonal rhythm 17.68 10.45 10 630303 75 79114000
Cholecystitis chronic 17.67 10.45 32 630281 9874 79104201
Normocytic anaemia 17.66 10.45 73 630240 4134 79109941
Angiocardiogram 17.64 10.45 15 630298 230 79113845
Blood lactic acid 17.63 10.45 20 630293 443 79113632
Ventricular arrhythmia 17.58 10.45 125 630188 8715 79105360
Cerebral microangiopathy 17.52 10.45 16 630297 271 79113804
Hepatic vein dilatation 17.49 10.45 15 630298 233 79113842
Atrioventricular block first degree 17.46 10.45 163 630150 12328 79101747
Oligohydramnios 17.38 10.45 3 630310 3409 79110666
Injection site bruising 17.36 10.45 224 630089 40778 79073297
Product odour abnormal 17.35 10.45 35 630278 1309 79112766
Chronic coronary syndrome 17.34 10.45 11 630302 104 79113971
Hypovolaemia 17.33 10.45 215 630098 17476 79096599
Acute left ventricular failure 17.33 10.45 42 630271 1782 79112293
Coronary artery thrombosis 17.28 10.45 59 630254 3047 79111028
Blood urine present 17.22 10.45 250 630063 21047 79093028
Gastroduodenal haemorrhage 17.19 10.45 16 630297 278 79113797
Periorbital haematoma 17.16 10.45 29 630284 945 79113130
Ankylosing spondylitis 17.16 10.45 45 630268 12160 79101915
Diverticulum intestinal haemorrhagic 17.15 10.45 70 630243 3941 79110134
Herpes simplex 17.08 10.45 45 630268 12142 79101933
Parainfluenzae virus infection 17.08 10.45 12 630301 5670 79108405
Cardiac pacemaker insertion 17.07 10.45 91 630222 5731 79108344
Iliac artery stenosis 17.06 10.45 13 630300 169 79113906
Ventricular extrasystoles 17.01 10.45 234 630079 19470 79094605
Conjunctivitis 17.01 10.45 126 630187 25589 79088486
Abnormal dreams 17.00 10.45 151 630162 11261 79102814
Heart valve incompetence 17.00 10.45 61 630252 3230 79110845
Cystostomy 16.94 10.45 10 630303 82 79113993
Inclusion body myositis 16.93 10.45 8 630305 39 79114036
Dilatation atrial 16.93 10.45 66 630247 3638 79110437
Vaginal haemorrhage 16.89 10.45 102 630211 21715 79092360
Seronegative arthritis 16.82 10.45 8 630305 4684 79109391
Hepatic ischaemia 16.80 10.45 31 630282 1084 79112991
Pulmonary oedema 16.78 10.45 856 629457 87398 79026677
Metastases to liver 16.75 10.45 143 630170 28171 79085904
Hyperglycaemic hyperosmolar nonketotic syndrome 16.75 10.45 48 630265 2255 79111820
Hepatosplenomegaly 16.73 10.45 14 630299 6055 79108020
Osteoporosis 16.68 10.45 314 629999 53798 79060277
Hepatojugular reflux 16.67 10.45 23 630290 625 79113450
Multiple injuries 16.56 10.45 63 630250 3432 79110643
Gouty arthritis 16.48 10.45 36 630277 1425 79112650
Generalised tonic-clonic seizure 16.41 10.45 246 630067 43664 79070411
Ecchymosis 16.30 10.45 188 630125 15018 79099057
Pulmonary tuberculosis 16.30 10.45 23 630290 7842 79106233
Prolonged expiration 16.29 10.45 33 630280 1238 79112837
Mitral valve calcification 16.28 10.45 36 630277 1437 79112638
Clonus 16.27 10.45 18 630295 6822 79107253
Fibrous histiocytoma 16.26 10.45 24 630289 695 79113380
Nicotine dependence 16.25 10.45 28 630285 927 79113148
Device malfunction 16.22 10.45 101 630212 21347 79092728
Decreased appetite 16.17 10.45 3007 627306 339411 78774664
Incision site haemorrhage 16.12 10.45 30 630283 1056 79113019
Breast cancer metastatic 16.06 10.45 27 630286 8575 79105500
Ludwig angina 16.06 10.45 15 630298 262 79113813
Pelvic mass 16.05 10.45 32 630281 1187 79112888
Peripheral coldness 16.04 10.45 195 630118 15775 79098300
Cardiac amyloidosis 16.04 10.45 41 630272 1799 79112276
Nodular rash 16.00 10.45 16 630297 305 79113770
Coronary angioplasty 16.00 10.45 18 630295 395 79113680
Food interaction 15.96 10.45 39 630274 1663 79112412
Radiculitis brachial 15.96 10.45 9 630304 67 79114008
Pulmonary haemorrhage 15.95 10.45 61 630252 14656 79099419
Mood swings 15.89 10.45 92 630221 19788 79094287
Hyperinsulinaemic hypoglycaemia 15.87 10.45 12 630301 154 79113921
Catatonia 15.87 10.45 28 630285 8728 79105347
Blood pressure decreased 15.82 10.45 949 629364 98517 79015558
Dyspnoea paroxysmal nocturnal 15.78 10.45 46 630267 2182 79111893
Thrombotic microangiopathy 15.77 10.45 94 630219 20075 79094000
Burning feet syndrome 15.75 10.45 13 630300 191 79113884
Toe amputation 15.74 10.45 67 630246 3844 79110231
Haematoma muscle 15.73 10.45 51 630262 2564 79111511
Furuncle 15.72 10.45 108 630205 7446 79106629
Glomerular filtration rate abnormal 15.71 10.45 38 630275 1610 79112465
Escherichia infection 15.71 10.45 81 630232 17936 79096139
Hepatitis B 15.69 10.45 26 630287 8306 79105769
Blood cholesterol 15.68 10.45 23 630290 662 79113413
Thrombotic thrombocytopenic purpura 15.62 10.45 95 630218 6281 79107794
Inappropriate schedule of product administration 15.62 10.45 880 629433 132748 78981327
Nail avulsion 15.58 10.45 11 630302 126 79113949
Systemic candida 15.57 10.45 18 630295 6688 79107387
Blepharospasm 15.52 10.45 14 630299 5837 79108238
Anaphylactic reaction 15.50 10.45 524 629789 83219 79030856
Nightmare 15.50 10.45 289 630024 25572 79088503
Lymphadenopathy 15.49 10.45 312 630001 52935 79061140
Device use error 15.49 10.45 20 630293 7081 79106994
Mitral valve disease 15.46 10.45 58 630255 3139 79110936
Movement disorder 15.44 10.45 302 630011 26957 79087118
Hyperlactacidaemia 15.42 10.45 86 630227 5509 79108566
Lymphoproliferative disorder 15.42 10.45 13 630300 5602 79108473
Blood glucose fluctuation 15.40 10.45 98 630215 6584 79107491
Mucous stools 15.38 10.45 11 630302 5151 79108924
Encephalitis toxic 15.34 10.45 15 630298 278 79113797
Prostate cancer recurrent 15.28 10.45 25 630288 793 79113282
Consciousness fluctuating 15.26 10.45 42 630271 1927 79112148
Non-cardiac chest pain 15.23 10.45 128 630185 9396 79104679
Unintended pregnancy 15.22 10.45 6 630307 3927 79110148
BK virus infection 15.21 10.45 29 630284 8775 79105300
Hiatus hernia 15.20 10.45 264 630049 23048 79091027
Urinary occult blood positive 15.15 10.45 13 630300 202 79113873
Muscle relaxant therapy 15.13 10.45 12 630301 166 79113909
Hypokinesia 15.12 10.45 223 630090 18837 79095238
Pelvic cyst 15.08 10.45 8 630305 52 79114023
Peripheral nerve palsy 15.08 10.45 8 630305 52 79114023
Atheroembolism 15.08 10.45 16 630297 328 79113747
Blood magnesium decreased 15.04 10.45 198 630115 16314 79097761
Respiratory failure 15.02 10.45 1228 629085 179683 78934392
Eye haemorrhage 15.00 10.45 130 630183 9627 79104448
Laryngeal haematoma 14.95 10.45 12 630301 169 79113906
Aortic valve thickening 14.91 10.45 6 630307 18 79114057
QRS axis abnormal 14.86 10.45 43 630270 2031 79112044
Arthritis 14.84 10.45 749 629564 114131 78999944
Calcium deficiency 14.83 10.45 26 630287 873 79113202
Colitis microscopic 14.79 10.45 140 630173 10628 79103447
Benign gastrointestinal neoplasm 14.76 10.45 11 630302 138 79113937
Skin toxicity 14.70 10.45 27 630286 8287 79105788
Peroneal nerve injury 14.59 10.45 8 630305 56 79114019
Poisoning deliberate 14.59 10.45 88 630225 18740 79095335
Pneumonia fungal 14.52 10.45 43 630270 11167 79102908
Foot deformity 14.51 10.45 121 630192 23953 79090122
Hepatocellular carcinoma 14.48 10.45 31 630282 8990 79105085
Respiratory acidosis 14.48 10.45 43 630270 11157 79102918
Acute respiratory failure 14.47 10.45 592 629721 58949 79055126
Prostatic operation 14.47 10.45 14 630299 256 79113819
Intra-abdominal haematoma 14.44 10.45 53 630260 2838 79111237
Liver palpable 14.44 10.45 16 630297 345 79113730
Lichenoid keratosis 14.44 10.45 67 630246 3990 79110085
Brain natriuretic peptide increased 14.44 10.45 120 630193 8780 79105295
Electrocardiogram T wave inversion 14.43 10.45 82 630231 5290 79108785
Osteoarthritis 14.42 10.45 554 629759 86755 79027320
Iron deficiency anaemia 14.40 10.45 284 630029 25388 79088687
Drug screen positive 14.37 10.45 16 630297 6047 79108028
Aortic valve stenosis 14.35 10.45 81 630232 5213 79108862
Duodenitis 14.33 10.45 110 630203 7857 79106218
Epstein-Barr virus associated lymphoproliferative disorder 14.32 10.45 5 630308 3527 79110548
Hepatic cirrhosis 14.30 10.45 192 630121 34714 79079361
Acute lymphocytic leukaemia 14.28 10.45 11 630302 4958 79109117
Exposure to toxic agent 14.27 10.45 32 630281 9126 79104949
Multi-organ disorder 14.26 10.45 49 630264 2539 79111536
Musculoskeletal chest pain 14.24 10.45 275 630038 24489 79089586
Device related sepsis 14.22 10.45 17 630296 6223 79107852
Carcinoid tumour of the gastrointestinal tract 14.19 10.45 9 630304 85 79113990
Secondary immunodeficiency 14.14 10.45 4 630309 3230 79110845
Extrapyramidal disorder 14.12 10.45 113 630200 22566 79091509
Sarcopenia 14.09 10.45 18 630295 453 79113622
Rheumatoid lung 14.08 10.45 8 630305 4237 79109838
Collagen disorder 14.08 10.45 14 630299 265 79113810
Prothrombin consumption time prolonged 14.07 10.45 7 630306 39 79114036
Bilirubin conjugated abnormal 14.06 10.45 10 630303 116 79113959
Helicobacter test positive 14.01 10.45 32 630281 1306 79112769
Accidental exposure to product by child 14.00 10.45 3 630310 2923 79111152
Blood cholinesterase decreased 14.00 10.45 14 630299 267 79113808
Tobacco abuse 13.96 10.45 27 630286 979 79113096
Pharyngitis streptococcal 13.95 10.45 41 630272 10673 79103402
Blood creatinine abnormal 13.92 10.45 75 630238 4742 79109333
Left ventricular failure 13.88 10.45 126 630187 9455 79104620
Infection susceptibility increased 13.87 10.45 6 630307 3715 79110360
Amyloid related imaging abnormality-oedema/effusion 13.86 10.45 17 630296 410 79113665
Accelerated hypertension 13.85 10.45 22 630291 680 79113395
Dizziness postural 13.85 10.45 146 630167 11403 79102672
Tongue disorder 13.84 10.45 60 630253 13915 79100160
Cough decreased 13.83 10.45 5 630308 10 79114065
Subchondral insufficiency fracture 13.82 10.45 8 630305 63 79114012
Hypomania 13.79 10.45 24 630289 7520 79106555
Hypercalcaemia 13.78 10.45 217 630096 38213 79075862
Internal haemorrhage 13.75 10.45 118 630195 8715 79105360
Brain stem haematoma 13.71 10.45 10 630303 121 79113954
Cardiac discomfort 13.70 10.45 31 630282 1257 79112818
Skin haemorrhage 13.69 10.45 150 630163 11831 79102244
Transplant failure 13.69 10.45 10 630303 4631 79109444
Bone cyst 13.68 10.45 5 630308 3428 79110647
Ventricular dysfunction 13.67 10.45 88 630225 5935 79108140
Cerebral ischaemia 13.65 10.45 142 630171 11053 79103022
Bladder sphincter atony 13.58 10.45 10 630303 123 79113952
Pseudomonas infection 13.55 10.45 103 630210 20800 79093275
Hallucinations, mixed 13.49 10.45 21 630292 6878 79107197
Laryngitis 13.49 10.45 73 630240 15966 79098109
Paresis 13.46 10.45 68 630245 4193 79109882
Stevens-Johnson syndrome 13.43 10.45 223 630090 38943 79075132
Subarachnoid haematoma 13.43 10.45 14 630299 281 79113794
Wound haematoma 13.41 10.45 11 630302 160 79113915
Hepatic steatosis 13.39 10.45 392 629921 37346 79076729
Benign pancreatic neoplasm 13.38 10.45 7 630306 44 79114031
Scleritis 13.36 10.45 9 630304 4347 79109728
Arteriovenous fistula occlusion 13.32 10.45 19 630294 533 79113542
Hypertension 13.32 10.45 2884 627429 328108 78785967
Change of bowel habit 13.32 10.45 50 630263 2707 79111368
Xyphoid retraction 13.30 10.45 11 630302 162 79113913
Diabetic ketosis 13.24 10.45 18 630295 482 79113593
Femoral bruit 13.22 10.45 5 630308 12 79114063
Quadrantanopia 13.20 10.45 12 630301 202 79113873
Post stroke seizure 13.18 10.45 4 630309 3 79114072
Macular degeneration 13.17 10.45 142 630171 11154 79102921
Hypophagia 13.16 10.45 460 629853 44907 79069168
Leukocyturia 13.15 10.45 40 630273 1943 79112132
Penile discharge 13.13 10.45 7 630306 46 79114029
Acute pulmonary oedema 13.12 10.45 171 630142 14059 79100016
Cholelithiasis 13.11 10.45 525 629788 52139 79061936
Loss of consciousness 13.09 10.45 1518 628795 166425 78947650
Testicular pain 13.09 10.45 41 630272 2024 79112051
Device breakage 13.08 10.45 42 630271 10633 79103442
Postrenal failure 13.06 10.45 21 630292 656 79113419
Breast cancer 13.06 10.45 188 630125 33593 79080482
Cerebrovascular disorder 13.05 10.45 61 630252 3644 79110431
Vision blurred 13.05 10.45 989 629324 104909 79009166
Pain in jaw 12.96 10.45 272 630041 45879 79068196
Embedded device 12.95 10.45 5 630308 3314 79110761
Toxic anterior segment syndrome 12.89 10.45 3 630310 2761 79111314
Heat stroke 12.88 10.45 36 630277 1667 79112408
Osteolysis 12.87 10.45 10 630303 4488 79109587
Brain abscess 12.87 10.45 12 630301 4924 79109151
Uveitis 12.86 10.45 79 630234 16751 79097324
Sebaceous gland infection 12.82 10.45 11 630302 171 79113904
Product administered to patient of inappropriate age 12.79 10.45 15 630298 5538 79108537
Dry eye 12.75 10.45 210 630103 36721 79077354
Spontaneous haemorrhage 12.67 10.45 23 630290 794 79113281
Sopor 12.66 10.45 184 630129 32826 79081249
Copper metabolism disorder 12.65 10.45 4 630309 4 79114071
Soft tissue disorder 12.59 10.45 6 630307 3509 79110566
Gangrene 12.54 10.45 117 630196 8847 79105228
Muscle strain 12.52 10.45 123 630190 9432 79104643
Autoimmune myocarditis 12.51 10.45 16 630297 403 79113672
Tic 12.50 10.45 4 630309 2982 79111093
Aortic aneurysm rupture 12.50 10.45 30 630283 1265 79112810
Dermatitis acneiform 12.47 10.45 39 630274 9954 79104121
Neurosensory hypoacusis 12.46 10.45 12 630301 218 79113857
Decreased gait velocity 12.46 10.45 11 630302 178 79113897
Photophobia 12.45 10.45 103 630210 20425 79093650
Actinic keratosis 12.35 10.45 86 630227 5956 79108119
Antimitochondrial antibody positive 12.34 10.45 9 630304 109 79113966
Idiopathic intracranial hypertension 12.33 10.45 5 630308 3217 79110858
Lipids increased 12.32 10.45 35 630278 1636 79112439
Potentiating drug interaction 12.28 10.45 115 630198 8704 79105371
Dysphagia 12.24 10.45 1123 629190 121013 78993062
Renal disorder 12.23 10.45 427 629886 41678 79072397
Blood testosterone decreased 12.23 10.45 44 630269 2333 79111742
Dysgeusia 12.22 10.45 561 629752 56616 79057459
Aneurysm 12.19 10.45 58 630255 3490 79110585
Phimosis 12.18 10.45 19 630294 578 79113497
Wound haemorrhage 12.17 10.45 65 630248 4096 79109979
Atrial pressure increased 12.12 10.45 6 630307 33 79114042
Blood test abnormal 12.09 10.45 86 630227 17624 79096451
Wrong patient received product 12.08 10.45 70 630243 4548 79109527
Lethargy 12.07 10.45 771 629542 80521 79033554
Death 12.01 10.45 4155 626158 562359 78551716
Gastrointestinal tract mucosal pigmentation 11.99 10.45 26 630287 1024 79113051
Ear pain 11.99 10.45 185 630128 32684 79081391
Faecaloma 11.96 10.45 142 630171 11422 79102653
Urine flow decreased 11.95 10.45 27 630286 1094 79112981
Discoloured vomit 11.93 10.45 32 630281 1446 79112629
Wheezing 11.92 10.45 778 629535 115886 78998189
Restlessness 11.91 10.45 278 630035 46214 79067861
Drop attacks 11.91 10.45 26 630287 1029 79113046
Left ventricular hypertrophy 11.83 10.45 138 630175 11053 79103022
Nerve degeneration 11.82 10.45 13 630300 278 79113797
Hypercholesterolaemia 11.80 10.45 252 630061 22843 79091232
Hyponatraemic seizure 11.80 10.45 18 630295 537 79113538
Platelet aggregation test 11.80 10.45 7 630306 58 79114017
Haemoglobin increased 11.79 10.45 86 630227 6046 79108029
Sciatica 11.77 10.45 188 630125 33034 79081041
Acute myeloid leukaemia recurrent 11.77 10.45 6 630307 3377 79110698
End stage renal disease 11.75 10.45 148 630165 12072 79102003
Viraemia 11.74 10.45 4 630309 2865 79111210
Cholangiocarcinoma 11.74 10.45 45 630268 2461 79111614
Prevertebral soft tissue swelling of cervical space 11.70 10.45 6 630307 36 79114039
Ataxia 11.66 10.45 134 630179 24905 79089170
Mitochondrial toxicity 11.65 10.45 5 630308 3109 79110966
Lipids abnormal 11.63 10.45 19 630294 602 79113473
Carotid endarterectomy 11.62 10.45 10 630303 156 79113919
Right ventricular enlargement 11.59 10.45 20 630293 663 79113412
Erythema nodosum 11.57 10.45 15 630298 5302 79108773
Bundle branch block right 11.57 10.45 138 630175 11113 79102962
Primary hypoparathyroidism 11.57 10.45 6 630307 37 79114038
Progressive muscular atrophy 11.55 10.45 3 630310 0 79114075
Red blood cell acanthocytes present 11.55 10.45 3 630310 0 79114075
Foreign travel 11.55 10.45 3 630310 0 79114075
Implantable cardiac monitor insertion 11.55 10.45 3 630310 0 79114075
Leukocyte alkaline phosphatase increased 11.55 10.45 3 630310 0 79114075
Wrong dosage form 11.55 10.45 3 630310 0 79114075
Renal cyst 11.54 10.45 172 630141 14560 79099515
Gait deviation 11.51 10.45 7 630306 61 79114014
Lipid metabolism disorder 11.50 10.45 14 630299 335 79113740
Alanine aminotransferase abnormal 11.49 10.45 34 630279 8833 79105242
Drug eruption 11.46 10.45 262 630051 43673 79070402
Haemarthrosis 11.45 10.45 82 630231 5730 79108345
Myocardial rupture 11.42 10.45 12 630301 243 79113832
High density lipoprotein increased 11.42 10.45 27 630286 1127 79112948
Biliary fibrosis 11.40 10.45 4 630309 7 79114068
Oesophageal adenocarcinoma stage 0 11.40 10.45 4 630309 7 79114068
Haemorrhage urinary tract 11.37 10.45 44 630269 2417 79111658
Metastases to lymph nodes 11.33 10.45 43 630270 10354 79103721
Drug level decreased 11.32 10.45 67 630246 14335 79099740
Percutaneous coronary intervention 11.25 10.45 15 630298 394 79113681
Glucose urine present 11.25 10.45 35 630278 1721 79112354
Arterial disorder 11.25 10.45 38 630275 1952 79112123
Biopsy colon abnormal 11.24 10.45 8 630305 93 79113982
Mean platelet volume decreased 11.22 10.45 4 630309 2786 79111289
Rotator cuff syndrome 11.21 10.45 165 630148 13930 79100145
Adenocarcinoma gastric 11.19 10.45 35 630278 1726 79112349
Injection site extravasation 11.19 10.45 39 630274 9630 79104445
Sacroiliitis 11.19 10.45 8 630305 3746 79110329
Staphylococcal bacteraemia 11.18 10.45 54 630259 12164 79101911
Pseudohyponatraemia 11.14 10.45 9 630304 128 79113947
Waist circumference increased 11.14 10.45 34 630279 1655 79112420
Plasmacytoma 11.13 10.45 11 630302 4392 79109683
Brain stem infarction 11.13 10.45 38 630275 1963 79112112
Heart sounds 11.12 10.45 24 630289 942 79113133
Leukaemia recurrent 11.12 10.45 4 630309 2770 79111305
Nuchal rigidity 11.11 10.45 26 630287 1078 79112997
Throat clearing 11.10 10.45 46 630267 2608 79111467
Lymph node calcification 11.08 10.45 15 630298 400 79113675
Tendon injury 11.08 10.45 39 630274 2046 79112029
Alanine aminotransferase 11.07 10.45 10 630303 167 79113908
Pyonephrosis 11.03 10.45 8 630305 96 79113979
Throat irritation 11.01 10.45 243 630070 40703 79073372
Atrial enlargement 10.98 10.45 25 630288 1018 79113057
Failure to suspend medication 10.98 10.45 16 630297 458 79113617
Optic discs blurred 10.96 10.45 7 630306 67 79114008
Blue toe syndrome 10.95 10.45 18 630295 573 79113502
Flank pain 10.95 10.45 219 630094 19625 79094450
Mean cell haemoglobin concentration 10.95 10.45 6 630307 42 79114033
Intracranial mass 10.94 10.45 41 630272 2218 79111857
Peripheral paralysis 10.88 10.45 10 630303 171 79113904
Ligament sprain 10.86 10.45 158 630155 13306 79100769
Vitreous haemorrhage 10.86 10.45 58 630255 3655 79110420
Brain stem stroke 10.85 10.45 20 630293 699 79113376
Memory impairment 10.84 10.45 1025 629288 110709 79003366
Tonsillitis 10.84 10.45 23 630290 6691 79107384
Nephropathy toxic 10.83 10.45 106 630207 20313 79093762
Mycobacterium chelonae infection 10.81 10.45 3 630310 2453 79111622
Cytomegalovirus test positive 10.80 10.45 19 630294 5928 79108147
Hepatic function abnormal 10.79 10.45 693 629620 72414 79041661
Hypertensive angiopathy 10.76 10.45 8 630305 100 79113975
Mitral valve thickening 10.75 10.45 15 630298 412 79113663
Winged scapula 10.75 10.45 4 630309 9 79114066
Total cholesterol/HDL ratio increased 10.75 10.45 12 630301 261 79113814
Hepatitis C 10.75 10.45 53 630260 11872 79102203
Coronary artery embolism 10.75 10.45 13 630300 309 79113766
Smooth muscle antibody positive 10.74 10.45 10 630303 174 79113901
Device deployment issue 10.73 10.45 6 630307 3206 79110869
Urinary hesitation 10.73 10.45 64 630249 4202 79109873
Spinal stenosis 10.72 10.45 180 630133 15611 79098464
Blood calcitonin increased 10.72 10.45 6 630307 44 79114031
Hypoalbuminaemia 10.70 10.45 112 630201 21185 79092890
Mycobacterial infection 10.69 10.45 8 630305 3660 79110415
Urinary tract infection 10.66 10.45 2388 627925 272124 78841951
Subcutaneous abscess 10.65 10.45 30 630283 7919 79106156
Intracranial aneurysm 10.65 10.45 67 630246 4483 79109592
Patient dissatisfaction with treatment 10.64 10.45 10 630303 176 79113899
Paratracheal lymphadenopathy 10.64 10.45 10 630303 176 79113899
JC virus infection 10.64 10.45 9 630304 3872 79110203
Streptococcal infection 10.64 10.45 35 630278 8795 79105280
Cystic fibrosis 10.64 10.45 9 630304 3871 79110204
Metastases to lung 10.63 10.45 92 630221 18071 79096004
Subcapsular splenic haematoma 10.62 10.45 7 630306 71 79114004
Oedema genital 10.62 10.45 18 630295 588 79113487
Linear IgA disease 10.62 10.45 51 630262 3081 79110994
Eyelid retraction 10.61 10.45 6 630307 45 79114030
Mammogram abnormal 10.60 10.45 16 630297 473 79113602
Acute febrile neutrophilic dermatosis 10.59 10.45 9 630304 3863 79110212
Meningorrhagia 10.58 10.45 13 630300 314 79113761
Blood triglycerides decreased 10.58 10.45 11 630302 220 79113855
Bezoar 10.57 10.45 4 630309 2684 79111391
Tuberculin test positive 10.50 10.45 7 630306 3401 79110674
Swelling face 10.50 10.45 675 629638 70537 79043538
Micturition disorder 10.50 10.45 61 630252 3967 79110108
Portosplenomesenteric venous thrombosis 10.48 10.45 5 630308 25 79114050
Abdominal wall mass 10.48 10.45 5 630308 25 79114050
Nephrostomy 10.46 10.45 12 630301 269 79113806
Negative cardiac inotropic effect 10.46 10.45 4 630309 10 79114065
Deep vein thrombosis 10.46 10.45 818 629495 120101 78993974

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX15 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX19 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Slow Progression of Coronary Artery Disease indication
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Prevention of Transient Ischemic Attacks off-label use
Alcoholism contraindication 7200002
Hypothyroidism contraindication 40930008 DOID:1459
Low blood pressure contraindication 45007003
Hepatic failure contraindication 59927004
Chronic idiopathic constipation contraindication 82934008
Kidney disease contraindication 90708001 DOID:557
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Severe Aortic Valve Stenosis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic
pKa2 11.82 acidic
pKa3 13.63 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
20MG/5ML ATORVALIQ CMP DEV LLC N213260 Feb. 1, 2023 RX SUSPENSION ORAL 11654106 June 7, 2037 AS AN ADJUNCT TO DIET TO REDUCE LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN ADULTS AND PEDIATRIC PATIENTS AGED 10 YEARS AND OLDER WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA
20MG/5ML ATORVALIQ CMP DEV LLC N213260 Feb. 1, 2023 RX SUSPENSION ORAL 11654106 June 7, 2037 AS AN ADJUNCT TO OTHER LOW-DENSITY LIPOPROTEIN CHOLESTEROL (LDL-C) LOWERING THERAPIES, OR ALONE IF SUCH TREATMENTS ARE UNAVAILABLE, TO REDUCE LDL-C IN ADULTS AND PEDIATRIC PATIENTS AGED 10 YEARS AND OLDER WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 8 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.29 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 5.37 CHEMBL
Histone deacetylase 2 Enzyme IC50 4.65 CHEMBL
Histone deacetylase 1 Enzyme IC50 4.93 CHEMBL
Histone deacetylase 6 Enzyme IC50 4.84 CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.42 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 4.49 CHEMBL

External reference:

IDSource
4024041 VUID
N0000022046 NUI
D00887 KEGG_DRUG
134523-03-8 SECONDARY_CAS_RN
344423-98-9 SECONDARY_CAS_RN
1297766 RXNORM
C0286651 UMLSCUI
CHEBI:39548 CHEBI
117 PDB_CHEM_ID
CHEMBL1487 ChEMBL_ID
CHEMBL393220 ChEMBL_ID
CHEMBL1790017 ChEMBL_ID
D000069059 MESH_DESCRIPTOR_UI
DB01076 DRUGBANK_ID
2949 IUPHAR_LIGAND_ID
7259 INN_ID
A0JWA85V8F UNII
60823 PUBCHEM_CID
186242 MMSL
34584 MMSL
34879 MMSL
4226 MMSL
d04105 MMSL
108600003 SNOMEDCT_US
108601004 SNOMEDCT_US
1268949007 SNOMEDCT_US
373444002 SNOMEDCT_US
725658002 SNOMEDCT_US
4020999 VANDF
4024041 VANDF
006321 NDDF
006322 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 32 sections