Stem definition | Drug id | CAS RN |
---|---|---|
antihyperlipidaemic substances, HMG CoA reductase inhibitors | 257 | 134523-00-5 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.05 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
S (Water solubility) | 0.02 mg/mL | Hosey CM, Chan R, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 1 % | Hosey CM, Chan R, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 17, 1996 | FDA | PFIZER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myalgia | 1150.54 | 9.88 | 2500 | 323625 | 121819 | 50157180 |
Maternal exposure during pregnancy | 826.90 | 9.88 | 51 | 326074 | 159727 | 50119272 |
Rhabdomyolysis | 778.72 | 9.88 | 1102 | 325023 | 37925 | 50241074 |
Immune-mediated myositis | 744.55 | 9.88 | 273 | 325852 | 772 | 50278227 |
Pemphigus | 717.51 | 9.88 | 11 | 326114 | 120155 | 50158844 |
Drug ineffective | 661.53 | 9.88 | 2883 | 323242 | 816450 | 49462549 |
Systemic lupus erythematosus | 552.74 | 9.88 | 116 | 326009 | 140506 | 50138493 |
Exposure during pregnancy | 551.68 | 9.88 | 66 | 326059 | 120949 | 50158050 |
Hand deformity | 543.31 | 9.88 | 24 | 326101 | 100175 | 50178824 |
Glossodynia | 534.38 | 9.88 | 60 | 326065 | 115509 | 50163490 |
Contraindicated product administered | 516.07 | 9.88 | 159 | 325966 | 148799 | 50130200 |
Acute kidney injury | 458.52 | 9.88 | 2771 | 323354 | 225287 | 50053712 |
Treatment failure | 455.51 | 9.88 | 159 | 325966 | 137478 | 50141521 |
Cerebrovascular accident | 439.16 | 9.88 | 1476 | 324649 | 93204 | 50185795 |
Anti-cyclic citrullinated peptide antibody positive | 432.28 | 9.88 | 4 | 326121 | 70583 | 50208416 |
Synovitis | 431.19 | 9.88 | 131 | 325994 | 123734 | 50155265 |
Myocardial infarction | 398.90 | 9.88 | 1372 | 324753 | 87655 | 50191344 |
Myopathy | 383.80 | 9.88 | 378 | 325747 | 8761 | 50270238 |
Therapeutic product effect decreased | 361.65 | 9.88 | 214 | 325911 | 135836 | 50143163 |
Infusion related reaction | 355.47 | 9.88 | 341 | 325784 | 169216 | 50109783 |
Blood creatine phosphokinase increased | 352.75 | 9.88 | 620 | 325505 | 25747 | 50253252 |
Off label use | 343.86 | 9.88 | 1732 | 324393 | 472694 | 49806305 |
Pericarditis | 334.73 | 9.88 | 53 | 326072 | 78636 | 50200363 |
Wound | 333.52 | 9.88 | 132 | 325993 | 105662 | 50173337 |
Rheumatoid factor positive | 295.66 | 9.88 | 5 | 326120 | 49854 | 50229145 |
Arthropathy | 292.63 | 9.88 | 352 | 325773 | 157554 | 50121445 |
Drug intolerance | 279.40 | 9.88 | 624 | 325501 | 218480 | 50060519 |
Muscular weakness | 260.76 | 9.88 | 1258 | 324867 | 93755 | 50185244 |
Completed suicide | 256.23 | 9.88 | 283 | 325842 | 131606 | 50147393 |
Duodenal ulcer perforation | 243.68 | 9.88 | 12 | 326113 | 45599 | 50233400 |
Swelling | 238.54 | 9.88 | 594 | 325531 | 200278 | 50078721 |
Alopecia | 235.41 | 9.88 | 801 | 325324 | 244246 | 50034753 |
Necrotising myositis | 229.65 | 9.88 | 88 | 326037 | 292 | 50278707 |
Acute myocardial infarction | 228.44 | 9.88 | 551 | 325574 | 28722 | 50250277 |
Drug hypersensitivity | 228.18 | 9.88 | 2547 | 323578 | 248463 | 50030536 |
Discomfort | 223.50 | 9.88 | 221 | 325904 | 108159 | 50170840 |
Product use issue | 216.66 | 9.88 | 395 | 325730 | 149080 | 50129919 |
Rheumatoid arthritis | 214.18 | 9.88 | 634 | 325491 | 201916 | 50077083 |
Drug interaction | 209.72 | 9.88 | 2086 | 324039 | 197535 | 50081464 |
Joint swelling | 208.60 | 9.88 | 843 | 325282 | 244443 | 50034556 |
Abdominal discomfort | 205.98 | 9.88 | 782 | 325343 | 230859 | 50048140 |
Coronary artery disease | 205.18 | 9.88 | 534 | 325591 | 29192 | 50249807 |
Hypersensitivity | 204.09 | 9.88 | 707 | 325418 | 214454 | 50064545 |
Helicobacter infection | 199.30 | 9.88 | 39 | 326086 | 49663 | 50229336 |
Pain | 196.44 | 9.88 | 2593 | 323532 | 576310 | 49702689 |
Muscle spasms | 189.52 | 9.88 | 1422 | 324703 | 124131 | 50154868 |
Folliculitis | 184.70 | 9.88 | 19 | 326106 | 39206 | 50239793 |
Hypomagnesaemia | 175.48 | 9.88 | 431 | 325694 | 22725 | 50256274 |
Fall | 168.06 | 9.88 | 3061 | 323064 | 331871 | 49947128 |
Toxicity to various agents | 154.93 | 9.88 | 773 | 325352 | 211726 | 50067273 |
Blood glucose increased | 153.40 | 9.88 | 883 | 325242 | 70441 | 50208558 |
Polymyositis | 152.53 | 9.88 | 106 | 326019 | 1474 | 50277525 |
Sleep disorder due to general medical condition, insomnia type | 148.66 | 9.88 | 15 | 326110 | 31432 | 50247567 |
Hypoglycaemia | 145.15 | 9.88 | 707 | 325418 | 52874 | 50226125 |
Rash | 143.17 | 9.88 | 1973 | 324152 | 435498 | 49843501 |
Hyponatraemia | 142.28 | 9.88 | 1084 | 325041 | 95055 | 50183944 |
Stomatitis | 138.74 | 9.88 | 277 | 325848 | 101067 | 50177932 |
Hyperkalaemia | 137.85 | 9.88 | 645 | 325480 | 47444 | 50231555 |
Infection | 137.29 | 9.88 | 610 | 325515 | 172344 | 50106655 |
Lactic acidosis | 137.17 | 9.88 | 500 | 325625 | 32855 | 50246144 |
Irritable bowel syndrome | 135.06 | 9.88 | 82 | 326043 | 51359 | 50227640 |
Abortion spontaneous | 131.77 | 9.88 | 52 | 326073 | 41720 | 50237279 |
Febrile neutropenia | 131.09 | 9.88 | 270 | 325855 | 97397 | 50181602 |
Transient ischaemic attack | 130.91 | 9.88 | 481 | 325644 | 31729 | 50247270 |
Impaired healing | 130.83 | 9.88 | 154 | 325971 | 69632 | 50209367 |
Pregnancy | 130.18 | 9.88 | 18 | 326107 | 29559 | 50249440 |
Foetal exposure during pregnancy | 126.89 | 9.88 | 14 | 326111 | 27345 | 50251654 |
Device expulsion | 125.78 | 9.88 | 18 | 326107 | 28804 | 50250195 |
Chest pain | 120.25 | 9.88 | 1701 | 324424 | 175181 | 50103818 |
Cardiac failure congestive | 112.53 | 9.88 | 929 | 325196 | 83453 | 50195546 |
Atrial fibrillation | 112.42 | 9.88 | 1075 | 325050 | 100670 | 50178329 |
Angina pectoris | 112.30 | 9.88 | 398 | 325727 | 25790 | 50253209 |
Drug abuse | 112.25 | 9.88 | 132 | 325993 | 59714 | 50219285 |
Cholestasis | 111.48 | 9.88 | 389 | 325736 | 25012 | 50253987 |
Muscle injury | 110.96 | 9.88 | 50 | 326075 | 37061 | 50241938 |
Hepatic enzyme increased | 109.31 | 9.88 | 484 | 325641 | 136896 | 50142103 |
Sinusitis | 109.06 | 9.88 | 648 | 325477 | 169910 | 50109089 |
Low density lipoprotein increased | 108.95 | 9.88 | 157 | 325968 | 5489 | 50273510 |
Ischaemic stroke | 108.51 | 9.88 | 285 | 325840 | 15663 | 50263336 |
Hypertensive emergency | 106.37 | 9.88 | 85 | 326040 | 1478 | 50277521 |
Asthenia | 103.04 | 9.88 | 2738 | 323387 | 316304 | 49962695 |
Drug-induced liver injury | 102.19 | 9.88 | 405 | 325720 | 27690 | 50251309 |
Hemiplegia | 101.86 | 9.88 | 176 | 325949 | 7205 | 50271794 |
Liver function test abnormal | 98.64 | 9.88 | 554 | 325571 | 43785 | 50235214 |
Neurologic neglect syndrome | 96.48 | 9.88 | 78 | 326047 | 1380 | 50277619 |
Autoimmune hepatitis | 95.65 | 9.88 | 173 | 325952 | 7346 | 50271653 |
Angina unstable | 93.98 | 9.88 | 161 | 325964 | 6545 | 50272454 |
Diabetic ketoacidosis | 93.01 | 9.88 | 290 | 325835 | 17582 | 50261417 |
Myositis | 92.93 | 9.88 | 176 | 325949 | 7744 | 50271255 |
Carotid artery thrombosis | 92.50 | 9.88 | 77 | 326048 | 1422 | 50277577 |
Rheumatic fever | 88.32 | 9.88 | 5 | 326120 | 16862 | 50262137 |
Pyrexia | 88.18 | 9.88 | 1825 | 324300 | 378378 | 49900621 |
Gastrointestinal haemorrhage | 87.16 | 9.88 | 787 | 325338 | 72534 | 50206465 |
Intentional overdose | 86.24 | 9.88 | 170 | 325955 | 62334 | 50216665 |
Ill-defined disorder | 84.98 | 9.88 | 138 | 325987 | 54516 | 50224483 |
Syncope | 84.77 | 9.88 | 1026 | 325099 | 101976 | 50177023 |
Premature delivery | 84.14 | 9.88 | 24 | 326101 | 23639 | 50255360 |
Neutropenia | 83.93 | 9.88 | 583 | 325542 | 147382 | 50131617 |
Caesarean section | 83.89 | 9.88 | 4 | 326121 | 15635 | 50263364 |
Malignant neoplasm progression | 83.45 | 9.88 | 198 | 325927 | 67926 | 50211073 |
Swollen joint count increased | 82.47 | 9.88 | 3 | 326122 | 14870 | 50264129 |
Dizziness | 82.37 | 9.88 | 2863 | 323262 | 343506 | 49935493 |
Premature baby | 81.07 | 9.88 | 11 | 326114 | 18326 | 50260673 |
Coronary artery occlusion | 81.04 | 9.88 | 161 | 325964 | 7342 | 50271657 |
Renal failure | 78.73 | 9.88 | 1041 | 325084 | 105592 | 50173407 |
Live birth | 77.10 | 9.88 | 8 | 326117 | 16400 | 50262599 |
Condition aggravated | 76.70 | 9.88 | 1400 | 324725 | 295658 | 49983341 |
Anaemia | 75.59 | 9.88 | 2146 | 323979 | 250310 | 50028689 |
Melaena | 75.27 | 9.88 | 358 | 325767 | 26506 | 50252493 |
Intentional product use issue | 74.66 | 9.88 | 250 | 325875 | 76668 | 50202331 |
C-reactive protein increased | 72.38 | 9.88 | 205 | 325920 | 66269 | 50212730 |
Adjustment disorder | 71.15 | 9.88 | 76 | 326049 | 1943 | 50277056 |
Hepatocellular injury | 69.26 | 9.88 | 341 | 325784 | 25606 | 50253393 |
Gastrointestinal disorder | 69.08 | 9.88 | 343 | 325782 | 94113 | 50184886 |
Myocardial ischaemia | 68.53 | 9.88 | 197 | 325928 | 11416 | 50267583 |
Acute coronary syndrome | 68.40 | 9.88 | 172 | 325953 | 9202 | 50269797 |
Rectal haemorrhage | 68.18 | 9.88 | 454 | 325671 | 38104 | 50240895 |
Hepatitis cholestatic | 68.17 | 9.88 | 133 | 325992 | 5984 | 50273015 |
Glycosylated haemoglobin increased | 67.58 | 9.88 | 185 | 325940 | 10421 | 50268578 |
Blister | 66.66 | 9.88 | 303 | 325822 | 85115 | 50193884 |
Cerebral haemorrhage | 66.24 | 9.88 | 347 | 325778 | 26705 | 50252294 |
Bradycardia | 64.96 | 9.88 | 668 | 325457 | 63758 | 50215241 |
Product use in unapproved indication | 64.35 | 9.88 | 459 | 325666 | 115360 | 50163639 |
Hip arthroplasty | 63.90 | 9.88 | 61 | 326064 | 30368 | 50248631 |
Intentional self-injury | 63.28 | 9.88 | 35 | 326090 | 23077 | 50255922 |
Pemphigoid | 62.89 | 9.88 | 126 | 325999 | 5781 | 50273218 |
Pancreatitis acute | 62.18 | 9.88 | 311 | 325814 | 23501 | 50255498 |
Coronary artery stenosis | 61.46 | 9.88 | 104 | 326021 | 4185 | 50274814 |
Macular degeneration | 60.26 | 9.88 | 217 | 325908 | 14171 | 50264828 |
Diabetes mellitus | 60.16 | 9.88 | 530 | 325595 | 48503 | 50230496 |
Cardiac disorder | 59.87 | 9.88 | 478 | 325647 | 42501 | 50236498 |
Renal impairment | 59.35 | 9.88 | 747 | 325378 | 74914 | 50204085 |
Hepatitis | 59.06 | 9.88 | 376 | 325749 | 31077 | 50247922 |
Atrioventricular block | 58.29 | 9.88 | 129 | 325996 | 6349 | 50272650 |
Labelled drug-drug interaction medication error | 58.25 | 9.88 | 174 | 325951 | 10303 | 50268696 |
Incorrect dosage administered | 57.74 | 9.88 | 63 | 326062 | 1651 | 50277348 |
Jaundice | 57.31 | 9.88 | 328 | 325797 | 26101 | 50252898 |
Decreased appetite | 57.08 | 9.88 | 1697 | 324428 | 199226 | 50079773 |
Dysarthria | 56.55 | 9.88 | 424 | 325701 | 36979 | 50242020 |
Blood triglycerides increased | 56.52 | 9.88 | 181 | 325944 | 11131 | 50267868 |
Nasopharyngitis | 55.97 | 9.88 | 890 | 325235 | 192037 | 50086962 |
Hepatitis acute | 55.93 | 9.88 | 144 | 325981 | 7817 | 50271182 |
Injection site erythema | 55.43 | 9.88 | 271 | 325854 | 74665 | 50204334 |
Chromaturia | 55.22 | 9.88 | 213 | 325912 | 14377 | 50264622 |
Personality disorder | 54.38 | 9.88 | 99 | 326026 | 4225 | 50274774 |
Injection site reaction | 53.94 | 9.88 | 155 | 325970 | 49877 | 50229122 |
Knee arthroplasty | 52.52 | 9.88 | 94 | 326031 | 35752 | 50243247 |
Diabetes mellitus inadequate control | 52.31 | 9.88 | 195 | 325930 | 12950 | 50266049 |
Chronic kidney disease | 51.99 | 9.88 | 436 | 325689 | 39335 | 50239664 |
Musculoskeletal stiffness | 51.89 | 9.88 | 553 | 325572 | 127928 | 50151071 |
International normalised ratio increased | 51.17 | 9.88 | 463 | 325662 | 42689 | 50236310 |
Leukopenia | 50.64 | 9.88 | 243 | 325882 | 67285 | 50211714 |
Neurotoxicity | 50.50 | 9.88 | 16 | 326109 | 14724 | 50264275 |
Red blood cell sedimentation rate abnormal | 50.47 | 9.88 | 21 | 326104 | 16322 | 50262677 |
Haematochezia | 50.44 | 9.88 | 434 | 325691 | 39448 | 50239551 |
Cardiac failure | 49.10 | 9.88 | 725 | 325400 | 75315 | 50203684 |
Swollen tongue | 48.76 | 9.88 | 334 | 325791 | 28296 | 50250703 |
Mixed liver injury | 48.55 | 9.88 | 83 | 326042 | 3368 | 50275631 |
Pain in extremity | 48.05 | 9.88 | 2184 | 323941 | 270681 | 50008318 |
Oedema peripheral | 47.55 | 9.88 | 1344 | 324781 | 156617 | 50122382 |
Lower respiratory tract infection | 46.90 | 9.88 | 390 | 325735 | 94811 | 50184188 |
Injection site swelling | 46.82 | 9.88 | 127 | 325998 | 41646 | 50237353 |
Injection site pain | 46.82 | 9.88 | 473 | 325652 | 110551 | 50168448 |
Atrioventricular block complete | 46.67 | 9.88 | 127 | 325998 | 7128 | 50271871 |
Drug resistance | 46.14 | 9.88 | 33 | 326092 | 18956 | 50260043 |
Carotid arteriosclerosis | 46.14 | 9.88 | 43 | 326082 | 928 | 50278071 |
Premature labour | 46.01 | 9.88 | 9 | 326116 | 11467 | 50267532 |
Amnesia | 45.89 | 9.88 | 445 | 325680 | 41815 | 50237184 |
Autoimmune myositis | 45.21 | 9.88 | 18 | 326107 | 68 | 50278931 |
Bone erosion | 45.13 | 9.88 | 10 | 326115 | 11677 | 50267322 |
Suicide attempt | 44.99 | 9.88 | 176 | 325949 | 51556 | 50227443 |
Device dislocation | 44.30 | 9.88 | 44 | 326081 | 21502 | 50257497 |
Dehydration | 44.20 | 9.88 | 1291 | 324834 | 151158 | 50127841 |
Labile blood pressure | 44.12 | 9.88 | 54 | 326071 | 1606 | 50277393 |
Muscle necrosis | 44.00 | 9.88 | 32 | 326093 | 480 | 50278519 |
Polymyalgia rheumatica | 43.31 | 9.88 | 68 | 326057 | 2568 | 50276431 |
Dementia | 43.24 | 9.88 | 211 | 325914 | 15786 | 50263213 |
Cytomegalovirus infection | 42.62 | 9.88 | 32 | 326093 | 17930 | 50261069 |
Blood alkaline phosphatase increased | 41.66 | 9.88 | 397 | 325728 | 37129 | 50241870 |
Hemiparesis | 41.64 | 9.88 | 246 | 325879 | 19802 | 50259197 |
Muscle atrophy | 41.24 | 9.88 | 109 | 326016 | 6012 | 50272987 |
Carotid artery stenosis | 41.21 | 9.88 | 93 | 326032 | 4638 | 50274361 |
Therapeutic product effect incomplete | 41.06 | 9.88 | 384 | 325741 | 91131 | 50187868 |
Large intestine polyp | 40.98 | 9.88 | 122 | 326003 | 7210 | 50271789 |
Accidental exposure to product | 40.97 | 9.88 | 53 | 326072 | 23004 | 50255995 |
Myelosuppression | 40.74 | 9.88 | 18 | 326107 | 13499 | 50265500 |
Chronic obstructive pulmonary disease | 39.97 | 9.88 | 523 | 325602 | 52912 | 50226087 |
Blood loss anaemia | 39.55 | 9.88 | 129 | 325996 | 8010 | 50270989 |
Infective pulmonary exacerbation of cystic fibrosis | 39.48 | 9.88 | 3 | 326122 | 7906 | 50271093 |
Hyperglycaemia | 39.36 | 9.88 | 383 | 325742 | 36022 | 50242977 |
Coma | 39.06 | 9.88 | 211 | 325914 | 56668 | 50222331 |
Hepatitis toxic | 38.66 | 9.88 | 67 | 326058 | 2749 | 50276250 |
Haemorrhage intracranial | 38.44 | 9.88 | 170 | 325955 | 12204 | 50266795 |
Sensory loss | 37.92 | 9.88 | 123 | 326002 | 7615 | 50271384 |
Therapeutic response decreased | 37.77 | 9.88 | 166 | 325959 | 47065 | 50231934 |
Pre-eclampsia | 37.60 | 9.88 | 4 | 326121 | 8040 | 50270959 |
Vascular stent stenosis | 37.43 | 9.88 | 29 | 326096 | 481 | 50278518 |
Blood pressure increased | 37.38 | 9.88 | 1123 | 325002 | 132009 | 50146990 |
Psoriatic arthropathy | 37.18 | 9.88 | 166 | 325959 | 46866 | 50232133 |
Product monitoring error | 36.96 | 9.88 | 65 | 326060 | 2699 | 50276300 |
Pancytopenia | 36.67 | 9.88 | 355 | 325770 | 83675 | 50195324 |
Mucosal inflammation | 36.57 | 9.88 | 134 | 325991 | 40008 | 50238991 |
Haematoma | 36.50 | 9.88 | 328 | 325797 | 30182 | 50248817 |
Gamma-glutamyltransferase increased | 36.23 | 9.88 | 320 | 325805 | 29303 | 50249696 |
Low density lipoprotein abnormal | 36.20 | 9.88 | 19 | 326106 | 152 | 50278847 |
Aphasia | 35.99 | 9.88 | 310 | 325815 | 28184 | 50250815 |
Cholestatic liver injury | 35.82 | 9.88 | 54 | 326071 | 1967 | 50277032 |
Dyspnoea | 35.45 | 9.88 | 4038 | 322087 | 543570 | 49735429 |
Blood cholesterol abnormal | 35.19 | 9.88 | 57 | 326068 | 2211 | 50276788 |
Blood glucose decreased | 34.99 | 9.88 | 219 | 325906 | 17992 | 50261007 |
Gait disturbance | 34.80 | 9.88 | 1237 | 324888 | 148768 | 50130231 |
Respiratory depression | 34.64 | 9.88 | 17 | 326108 | 11993 | 50267006 |
Haematemesis | 34.16 | 9.88 | 300 | 325825 | 27425 | 50251574 |
Mitral valve incompetence | 34.13 | 9.88 | 211 | 325914 | 17260 | 50261739 |
Abortion induced | 34.12 | 9.88 | 9 | 326116 | 9335 | 50269664 |
Hypocalcaemia | 34 | 9.88 | 292 | 325833 | 26524 | 50252475 |
Panniculitis | 33.40 | 9.88 | 7 | 326118 | 8496 | 50270503 |
Neutrophil count decreased | 33.14 | 9.88 | 168 | 325957 | 45858 | 50233141 |
Upper gastrointestinal haemorrhage | 32.81 | 9.88 | 196 | 325929 | 15839 | 50263160 |
Motor dysfunction | 32.68 | 9.88 | 120 | 326005 | 7911 | 50271088 |
Weight decreased | 32.67 | 9.88 | 1741 | 324384 | 219504 | 50059495 |
Arteriosclerosis | 32.32 | 9.88 | 130 | 325995 | 8947 | 50270052 |
Peripheral artery stenosis | 32.28 | 9.88 | 27 | 326098 | 502 | 50278497 |
Body height decreased | 32.05 | 9.88 | 128 | 325997 | 8780 | 50270219 |
Myocardial necrosis marker increased | 31.67 | 9.88 | 44 | 326081 | 1486 | 50277513 |
Product substitution issue | 31.49 | 9.88 | 176 | 325949 | 13881 | 50265118 |
Eosinophilia | 31.40 | 9.88 | 217 | 325908 | 18435 | 50260564 |
Euglycaemic diabetic ketoacidosis | 31.06 | 9.88 | 61 | 326064 | 2758 | 50276241 |
Ischaemic cardiomyopathy | 30.44 | 9.88 | 54 | 326071 | 2258 | 50276741 |
Tenosynovitis | 30.40 | 9.88 | 15 | 326110 | 10550 | 50268449 |
Cerebral infarction | 29.93 | 9.88 | 240 | 325885 | 21364 | 50257635 |
Muscle disorder | 29.86 | 9.88 | 78 | 326047 | 4272 | 50274727 |
Subdural haematoma | 29.60 | 9.88 | 163 | 325962 | 12784 | 50266215 |
High density lipoprotein decreased | 29.53 | 9.88 | 45 | 326080 | 1655 | 50277344 |
Myoglobin blood increased | 29.53 | 9.88 | 39 | 326086 | 1254 | 50277745 |
Myopathy toxic | 29.46 | 9.88 | 23 | 326102 | 386 | 50278613 |
Confusional state | 29.46 | 9.88 | 1473 | 324652 | 184455 | 50094544 |
Disease progression | 29.20 | 9.88 | 438 | 325687 | 95428 | 50183571 |
Dermatomyositis | 29.13 | 9.88 | 51 | 326074 | 2110 | 50276889 |
Liver disorder | 28.54 | 9.88 | 366 | 325759 | 36856 | 50242143 |
Blood creatine phosphokinase MB increased | 28.51 | 9.88 | 36 | 326089 | 1106 | 50277893 |
Diabetic metabolic decompensation | 28.33 | 9.88 | 41 | 326084 | 1439 | 50277560 |
Respiratory arrest | 28.12 | 9.88 | 99 | 326026 | 29910 | 50249089 |
Fibromyalgia | 28.11 | 9.88 | 172 | 325953 | 44806 | 50234193 |
Mobility decreased | 28.03 | 9.88 | 355 | 325770 | 79593 | 50199406 |
Uterine perforation | 28.00 | 9.88 | 4 | 326121 | 6411 | 50272588 |
Angioedema | 27.85 | 9.88 | 368 | 325757 | 37308 | 50241691 |
Foetal death | 27.81 | 9.88 | 9 | 326116 | 8171 | 50270828 |
Inappropriate antidiuretic hormone secretion | 27.76 | 9.88 | 162 | 325963 | 12981 | 50266018 |
Aldolase increased | 27.67 | 9.88 | 15 | 326110 | 129 | 50278870 |
Migraine | 27.63 | 9.88 | 331 | 325794 | 74949 | 50204050 |
Eating disorder | 27.57 | 9.88 | 182 | 325943 | 15227 | 50263772 |
Aortic stenosis | 27.56 | 9.88 | 74 | 326051 | 4120 | 50274879 |
Febrile bone marrow aplasia | 27.40 | 9.88 | 4 | 326121 | 6307 | 50272692 |
Rheumatoid nodule | 27.36 | 9.88 | 25 | 326100 | 12710 | 50266289 |
Diabetic retinopathy | 27.03 | 9.88 | 50 | 326075 | 2160 | 50276839 |
Hypokalaemia | 26.82 | 9.88 | 750 | 325375 | 87242 | 50191757 |
Oligohydramnios | 26.52 | 9.88 | 3 | 326122 | 5747 | 50273252 |
Incorrect route of product administration | 26.41 | 9.88 | 50 | 326075 | 18616 | 50260383 |
Enthesopathy | 26.13 | 9.88 | 7 | 326118 | 7186 | 50271813 |
Intestinal haemorrhage | 26.03 | 9.88 | 61 | 326064 | 3119 | 50275880 |
Affect lability | 26.00 | 9.88 | 121 | 326004 | 8877 | 50270122 |
Hepatic function abnormal | 25.76 | 9.88 | 323 | 325802 | 32358 | 50246641 |
Mouth swelling | 25.64 | 9.88 | 69 | 326056 | 3847 | 50275152 |
Urinary tract discomfort | 25.62 | 9.88 | 17 | 326108 | 218 | 50278781 |
Injection site pruritus | 25.54 | 9.88 | 154 | 325971 | 40257 | 50238742 |
Angiopathy | 25.37 | 9.88 | 71 | 326054 | 4051 | 50274948 |
Flatulence | 25.33 | 9.88 | 296 | 325829 | 29162 | 50249837 |
Stillbirth | 25.32 | 9.88 | 4 | 326121 | 5948 | 50273051 |
Renal disorder | 25.29 | 9.88 | 280 | 325845 | 27225 | 50251774 |
Head injury | 25.13 | 9.88 | 251 | 325874 | 23769 | 50255230 |
Cell death | 24.49 | 9.88 | 48 | 326077 | 2167 | 50276832 |
Device issue | 24.49 | 9.88 | 58 | 326067 | 19914 | 50259085 |
Amenorrhoea | 24.48 | 9.88 | 12 | 326113 | 8472 | 50270527 |
Lichen planopilaris | 24.31 | 9.88 | 6 | 326119 | 0 | 50278999 |
Traumatic coma | 24.29 | 9.88 | 11 | 326114 | 61 | 50278938 |
Hyperlipidaemia | 24.07 | 9.88 | 194 | 325931 | 17296 | 50261703 |
Anuria | 24.02 | 9.88 | 139 | 325986 | 11105 | 50267894 |
Post viral fatigue syndrome | 23.99 | 9.88 | 18 | 326107 | 284 | 50278715 |
Metastases to bone | 23.91 | 9.88 | 50 | 326075 | 17945 | 50261054 |
Hepatic ischaemia | 23.52 | 9.88 | 24 | 326101 | 581 | 50278418 |
Acute myeloid leukaemia | 23.48 | 9.88 | 38 | 326087 | 15036 | 50263963 |
Loss of personal independence in daily activities | 23.47 | 9.88 | 314 | 325811 | 69736 | 50209263 |
Hypovolaemic shock | 23.23 | 9.88 | 80 | 326045 | 5108 | 50273891 |
Dysphagia | 23.14 | 9.88 | 659 | 325466 | 76859 | 50202140 |
Poisoning deliberate | 23.12 | 9.88 | 11 | 326114 | 7901 | 50271098 |
Alanine aminotransferase increased | 23.10 | 9.88 | 739 | 325386 | 87620 | 50191379 |
Hypertensive cardiomyopathy | 23.10 | 9.88 | 15 | 326110 | 185 | 50278814 |
Stent placement | 22.94 | 9.88 | 61 | 326064 | 3377 | 50275622 |
Faeces discoloured | 22.82 | 9.88 | 180 | 325945 | 15944 | 50263055 |
Food allergy | 22.75 | 9.88 | 12 | 326113 | 8125 | 50270874 |
Retinal artery occlusion | 22.57 | 9.88 | 37 | 326088 | 1450 | 50277549 |
Maternal drugs affecting foetus | 22.55 | 9.88 | 3 | 326122 | 5074 | 50273925 |
Immunodeficiency | 22.52 | 9.88 | 38 | 326087 | 14790 | 50264209 |
Embolic stroke | 22.42 | 9.88 | 61 | 326064 | 3423 | 50275576 |
Malaise | 22.29 | 9.88 | 2479 | 323646 | 333053 | 49945946 |
Hypovolaemia | 22.20 | 9.88 | 120 | 326005 | 9345 | 50269654 |
Therapeutic drug monitoring analysis not performed | 22.17 | 9.88 | 25 | 326100 | 680 | 50278319 |
Hypertransaminasaemia | 22.03 | 9.88 | 62 | 326063 | 3549 | 50275450 |
Cardiotoxicity | 21.75 | 9.88 | 9 | 326116 | 7018 | 50271981 |
Suicidal ideation | 21.69 | 9.88 | 240 | 325885 | 55145 | 50223854 |
Carotid artery occlusion | 21.58 | 9.88 | 49 | 326076 | 2454 | 50276545 |
Haematotoxicity | 21.55 | 9.88 | 12 | 326113 | 7883 | 50271116 |
Mydriasis | 21.51 | 9.88 | 22 | 326103 | 10605 | 50268394 |
Myoglobinuria | 21.35 | 9.88 | 16 | 326109 | 252 | 50278747 |
Seizure | 21.35 | 9.88 | 587 | 325538 | 117287 | 50161712 |
Peripheral nerve palsy | 21.09 | 9.88 | 7 | 326118 | 13 | 50278986 |
Arterial stenosis | 21.09 | 9.88 | 22 | 326103 | 547 | 50278452 |
Psychotic disorder | 21.08 | 9.88 | 71 | 326054 | 21741 | 50257258 |
Device related infection | 21.08 | 9.88 | 66 | 326059 | 20669 | 50258330 |
Antimitochondrial antibody positive | 21.04 | 9.88 | 10 | 326115 | 63 | 50278936 |
Cardiac murmur | 20.92 | 9.88 | 130 | 325995 | 10654 | 50268345 |
Ankylosing spondylitis | 20.88 | 9.88 | 10 | 326115 | 7155 | 50271844 |
Interstitial lung disease | 20.88 | 9.88 | 469 | 325656 | 52707 | 50226292 |
Heavy menstrual bleeding | 20.79 | 9.88 | 43 | 326082 | 15494 | 50263505 |
Sedation | 20.76 | 9.88 | 114 | 326011 | 30496 | 50248503 |
Hepatic steatosis | 20.52 | 9.88 | 244 | 325881 | 24140 | 50254859 |
Cerebral haematoma | 20.45 | 9.88 | 56 | 326069 | 3155 | 50275844 |
Rectal polyp | 20.44 | 9.88 | 28 | 326097 | 933 | 50278066 |
Pancreatitis | 20.39 | 9.88 | 387 | 325738 | 42227 | 50236772 |
Grip strength decreased | 20.38 | 9.88 | 29 | 326096 | 12092 | 50266907 |
Subarachnoid haemorrhage | 20.34 | 9.88 | 129 | 325996 | 10647 | 50268352 |
Aspartate aminotransferase increased | 20.30 | 9.88 | 652 | 325473 | 77346 | 50201653 |
Unintentional medical device removal | 20.29 | 9.88 | 5 | 326120 | 5430 | 50273569 |
Arthralgia | 20.13 | 9.88 | 2498 | 323627 | 436204 | 49842795 |
Diverticulum | 19.99 | 9.88 | 127 | 325998 | 10487 | 50268512 |
Complication of device insertion | 19.92 | 9.88 | 7 | 326118 | 6034 | 50272965 |
Glomerular filtration rate decreased | 19.87 | 9.88 | 136 | 325989 | 11516 | 50267483 |
Urinary tract infection | 19.84 | 9.88 | 1689 | 324436 | 222331 | 50056668 |
Cervix neoplasm | 19.83 | 9.88 | 14 | 326111 | 200 | 50278799 |
Urine output decreased | 19.82 | 9.88 | 125 | 326000 | 10296 | 50268703 |
Spinal epidural haematoma | 19.82 | 9.88 | 28 | 326097 | 961 | 50278038 |
Pathogen resistance | 19.80 | 9.88 | 6 | 326119 | 5683 | 50273316 |
Chloropsia | 19.74 | 9.88 | 8 | 326117 | 32 | 50278967 |
Ocular myasthenia | 19.72 | 9.88 | 12 | 326113 | 131 | 50278868 |
Arterial occlusive disease | 19.70 | 9.88 | 72 | 326053 | 4736 | 50274263 |
Coronary artery thrombosis | 19.61 | 9.88 | 29 | 326096 | 1038 | 50277961 |
Pulmonary renal syndrome | 19.56 | 9.88 | 18 | 326107 | 382 | 50278617 |
Hepatorenal syndrome | 19.55 | 9.88 | 38 | 326087 | 1705 | 50277294 |
Dysgeusia | 19.52 | 9.88 | 356 | 325769 | 38560 | 50240439 |
Urinary tract obstruction | 19.47 | 9.88 | 38 | 326087 | 1710 | 50277289 |
Presyncope | 19.43 | 9.88 | 240 | 325885 | 23958 | 50255041 |
Transplant rejection | 19.32 | 9.88 | 20 | 326105 | 9589 | 50269410 |
Coronary artery restenosis | 19.30 | 9.88 | 17 | 326108 | 340 | 50278659 |
Eructation | 19.30 | 9.88 | 94 | 326031 | 7027 | 50271972 |
Haematuria | 19.28 | 9.88 | 251 | 325874 | 25362 | 50253637 |
Calcium deficiency | 19.19 | 9.88 | 27 | 326098 | 923 | 50278076 |
Tuberculosis | 19.16 | 9.88 | 22 | 326103 | 10061 | 50268938 |
Balance disorder | 19.14 | 9.88 | 593 | 325532 | 69997 | 50209002 |
Gastrointestinal toxicity | 19.13 | 9.88 | 70 | 326055 | 4607 | 50274392 |
Metastases to liver | 19.05 | 9.88 | 66 | 326059 | 20038 | 50258961 |
Dysstasia | 19.03 | 9.88 | 187 | 325938 | 17632 | 50261367 |
Memory impairment | 19.02 | 9.88 | 657 | 325468 | 78703 | 50200296 |
Overdose | 19.00 | 9.88 | 493 | 325632 | 99234 | 50179765 |
Metastases to central nervous system | 18.96 | 9.88 | 27 | 326098 | 11255 | 50267744 |
Left atrial enlargement | 18.91 | 9.88 | 15 | 326110 | 258 | 50278741 |
Lip swelling | 18.86 | 9.88 | 243 | 325882 | 24493 | 50254506 |
Coronary artery bypass | 18.79 | 9.88 | 44 | 326081 | 2249 | 50276750 |
Duodenal ulcer | 18.77 | 9.88 | 90 | 326035 | 6685 | 50272314 |
Poisoning | 18.74 | 9.88 | 32 | 326093 | 12397 | 50266602 |
Gastric ulcer | 18.73 | 9.88 | 215 | 325910 | 21090 | 50257909 |
Coordination abnormal | 18.72 | 9.88 | 133 | 325992 | 11401 | 50267598 |
Subacute cutaneous lupus erythematosus | 18.69 | 9.88 | 43 | 326082 | 2172 | 50276827 |
Adverse drug reaction | 18.69 | 9.88 | 247 | 325878 | 54975 | 50224024 |
Diabetic nephropathy | 18.57 | 9.88 | 32 | 326093 | 1307 | 50277692 |
Blood urea increased | 18.54 | 9.88 | 233 | 325892 | 23352 | 50255647 |
Multiple sclerosis relapse | 18.53 | 9.88 | 182 | 325943 | 42782 | 50236217 |
Haemophagocytic lymphohistiocytosis | 18.48 | 9.88 | 17 | 326108 | 8616 | 50270383 |
Vertigo | 18.46 | 9.88 | 451 | 325674 | 51381 | 50227618 |
Arteriovenous fistula occlusion | 18.43 | 9.88 | 17 | 326108 | 362 | 50278637 |
Albuminuria | 18.39 | 9.88 | 13 | 326112 | 186 | 50278813 |
Periorbital haematoma | 18.28 | 9.88 | 23 | 326102 | 704 | 50278295 |
Orthostatic hypotension | 18.21 | 9.88 | 279 | 325846 | 29202 | 50249797 |
Bone marrow failure | 18.13 | 9.88 | 104 | 326021 | 27520 | 50251479 |
Peripheral arterial occlusive disease | 18.04 | 9.88 | 57 | 326068 | 3480 | 50275519 |
Hallucination, gustatory | 18.03 | 9.88 | 9 | 326116 | 64 | 50278935 |
Blood creatinine increased | 17.88 | 9.88 | 629 | 325496 | 75531 | 50203468 |
Lymphocyte count decreased | 17.83 | 9.88 | 98 | 326027 | 26209 | 50252790 |
Aspergillus infection | 17.72 | 9.88 | 11 | 326114 | 6810 | 50272189 |
Inflammation | 17.68 | 9.88 | 259 | 325866 | 56653 | 50222346 |
Stevens-Johnson syndrome | 17.66 | 9.88 | 76 | 326049 | 21676 | 50257323 |
Abnormal loss of weight | 17.61 | 9.88 | 72 | 326053 | 4992 | 50274007 |
Vascular stent occlusion | 17.57 | 9.88 | 8 | 326117 | 45 | 50278954 |
Ventricular hypertrophy | 17.50 | 9.88 | 53 | 326072 | 3162 | 50275837 |
Muscle relaxant therapy | 17.44 | 9.88 | 12 | 326113 | 164 | 50278835 |
Candida infection | 17.42 | 9.88 | 85 | 326040 | 23438 | 50255561 |
Ketoacidosis | 17.39 | 9.88 | 60 | 326065 | 3835 | 50275164 |
Blood creatine phosphokinase abnormal | 17.38 | 9.88 | 13 | 326112 | 204 | 50278795 |
Haemorrhagic transformation stroke | 17.38 | 9.88 | 28 | 326097 | 1081 | 50277918 |
Dysuria | 17.31 | 9.88 | 269 | 325856 | 28235 | 50250764 |
Intermittent claudication | 17.26 | 9.88 | 35 | 326090 | 1620 | 50277379 |
Psoriasis | 17.24 | 9.88 | 574 | 325551 | 68426 | 50210573 |
Epstein-Barr virus infection | 17.21 | 9.88 | 12 | 326113 | 6985 | 50272014 |
Subchondral insufficiency fracture | 17.02 | 9.88 | 8 | 326117 | 49 | 50278950 |
Cardiac failure acute | 16.98 | 9.88 | 101 | 326024 | 8149 | 50270850 |
Pallor | 16.90 | 9.88 | 226 | 325899 | 22973 | 50256026 |
Lipoprotein (a) increased | 16.90 | 9.88 | 7 | 326118 | 30 | 50278969 |
Coronary artery surgery | 16.88 | 9.88 | 8 | 326117 | 50 | 50278949 |
Neurosensory hypoacusis | 16.86 | 9.88 | 13 | 326112 | 214 | 50278785 |
Acne | 16.82 | 9.88 | 67 | 326058 | 19528 | 50259471 |
Epistaxis | 16.74 | 9.88 | 535 | 325590 | 63419 | 50215580 |
Acidosis | 16.64 | 9.88 | 118 | 326007 | 10109 | 50268890 |
Blood iron decreased | 16.62 | 9.88 | 130 | 325995 | 11485 | 50267514 |
Carotid artery disease | 16.59 | 9.88 | 33 | 326092 | 1506 | 50277493 |
Diverticulum intestinal | 16.57 | 9.88 | 79 | 326046 | 5854 | 50273145 |
Dyspnoea exertional | 16.54 | 9.88 | 440 | 325685 | 50793 | 50228206 |
Product prescribing error | 16.44 | 9.88 | 207 | 325918 | 20754 | 50258245 |
Pollakiuria | 16.41 | 9.88 | 230 | 325895 | 23621 | 50255378 |
Menstrual disorder | 16.36 | 9.88 | 4 | 326121 | 4366 | 50274633 |
Spur cell anaemia | 16.35 | 9.88 | 6 | 326119 | 17 | 50278982 |
Electrocardiogram abnormal | 16.23 | 9.88 | 94 | 326031 | 7511 | 50271488 |
Cholangiolitis | 16.20 | 9.88 | 4 | 326121 | 0 | 50278999 |
Tongue oedema | 16.16 | 9.88 | 58 | 326067 | 3781 | 50275218 |
Death | 16.13 | 9.88 | 1843 | 324282 | 323536 | 49955463 |
Microcytic anaemia | 16.01 | 9.88 | 50 | 326075 | 3034 | 50275965 |
Fatigue | 16.00 | 9.88 | 4186 | 321939 | 703415 | 49575584 |
Low birth weight baby | 15.96 | 9.88 | 9 | 326116 | 5872 | 50273127 |
Large intestinal haemorrhage | 15.95 | 9.88 | 28 | 326097 | 1161 | 50277838 |
Ear congestion | 15.94 | 9.88 | 38 | 326087 | 1965 | 50277034 |
Menstruation irregular | 15.92 | 9.88 | 10 | 326115 | 6152 | 50272847 |
Sinus bradycardia | 15.90 | 9.88 | 142 | 325983 | 13041 | 50265958 |
Joint destruction | 15.85 | 9.88 | 3 | 326122 | 3913 | 50275086 |
Blood electrolytes abnormal | 15.85 | 9.88 | 25 | 326100 | 948 | 50278051 |
Abnormal dreams | 15.73 | 9.88 | 109 | 326016 | 9268 | 50269731 |
Device adhesion issue | 15.67 | 9.88 | 3 | 326122 | 3882 | 50275117 |
Renal injury | 15.59 | 9.88 | 102 | 326023 | 8509 | 50270490 |
Prothrombin consumption time prolonged | 15.58 | 9.88 | 7 | 326118 | 38 | 50278961 |
Cerebral microangiopathy | 15.58 | 9.88 | 13 | 326112 | 241 | 50278758 |
Electrocardiogram QT prolonged | 15.45 | 9.88 | 441 | 325684 | 51445 | 50227554 |
Tumour lysis syndrome | 15.43 | 9.88 | 15 | 326110 | 7406 | 50271593 |
Device difficult to use | 15.33 | 9.88 | 25 | 326100 | 9861 | 50269138 |
Lower gastrointestinal haemorrhage | 15.32 | 9.88 | 86 | 326039 | 6793 | 50272206 |
Blood parathyroid hormone decreased | 15.24 | 9.88 | 14 | 326111 | 7100 | 50271899 |
Transaminases increased | 15.19 | 9.88 | 258 | 325867 | 27566 | 50251433 |
Polyuria | 15.19 | 9.88 | 88 | 326037 | 7033 | 50271966 |
Red blood cell sedimentation rate increased | 15.17 | 9.88 | 119 | 326006 | 29297 | 50249702 |
Saliva altered | 15.14 | 9.88 | 14 | 326111 | 299 | 50278700 |
Blood lactic acid | 15.13 | 9.88 | 9 | 326116 | 94 | 50278905 |
Muscle enzyme increased | 15.09 | 9.88 | 10 | 326115 | 128 | 50278871 |
Progressive multifocal leukoencephalopathy | 15.08 | 9.88 | 32 | 326093 | 11425 | 50267574 |
Glomerular filtration rate abnormal | 15.03 | 9.88 | 18 | 326107 | 523 | 50278476 |
Electrolyte imbalance | 14.98 | 9.88 | 173 | 325952 | 16996 | 50262003 |
Creatinine renal clearance decreased | 14.97 | 9.88 | 34 | 326091 | 11847 | 50267152 |
Jaundice cholestatic | 14.96 | 9.88 | 69 | 326056 | 5042 | 50273957 |
Injection site warmth | 14.91 | 9.88 | 43 | 326082 | 13823 | 50265176 |
Diabetic neuropathy | 14.90 | 9.88 | 54 | 326071 | 3537 | 50275462 |
Hypervolaemia | 14.87 | 9.88 | 239 | 325886 | 25260 | 50253739 |
Pulmonary toxicity | 14.77 | 9.88 | 73 | 326052 | 5489 | 50273510 |
Musculoskeletal chest pain | 14.69 | 9.88 | 183 | 325942 | 18303 | 50260696 |
Acute left ventricular failure | 14.64 | 9.88 | 22 | 326103 | 799 | 50278200 |
Blood creatinine abnormal | 14.64 | 9.88 | 44 | 326081 | 2614 | 50276385 |
Thrombocytopenia | 14.58 | 9.88 | 673 | 325452 | 127000 | 50151999 |
C-reactive protein abnormal | 14.57 | 9.88 | 112 | 326013 | 27697 | 50251302 |
Ventricular septal defect | 14.55 | 9.88 | 4 | 326121 | 4037 | 50274962 |
Thyroid disorder | 14.51 | 9.88 | 135 | 325990 | 12542 | 50266457 |
Haemorrhagic cyst | 14.48 | 9.88 | 11 | 326114 | 177 | 50278822 |
Aplastic anaemia | 14.43 | 9.88 | 17 | 326108 | 7686 | 50271313 |
Macular oedema | 14.37 | 9.88 | 54 | 326071 | 3600 | 50275399 |
Cataract | 14.36 | 9.88 | 403 | 325722 | 46897 | 50232102 |
Diarrhoea | 14.35 | 9.88 | 4125 | 322000 | 584351 | 49694648 |
Chest wall haematoma | 14.32 | 9.88 | 11 | 326114 | 180 | 50278819 |
Alveolar osteitis | 14.31 | 9.88 | 16 | 326109 | 431 | 50278568 |
Arterial insufficiency | 14.27 | 9.88 | 10 | 326115 | 141 | 50278858 |
Feeling abnormal | 14.25 | 9.88 | 965 | 325160 | 124527 | 50154472 |
Generalised tonic-clonic seizure | 14.24 | 9.88 | 105 | 326020 | 26205 | 50252794 |
Blood pressure inadequately controlled | 14.24 | 9.88 | 61 | 326064 | 4319 | 50274680 |
Muscle fatigue | 14.21 | 9.88 | 39 | 326086 | 2200 | 50276799 |
Blood sodium decreased | 14.18 | 9.88 | 203 | 325922 | 20944 | 50258055 |
Oral herpes | 14.16 | 9.88 | 77 | 326048 | 20648 | 50258351 |
Blood cholesterol decreased | 14.13 | 9.88 | 21 | 326104 | 755 | 50278244 |
Urinary occult blood positive | 14.12 | 9.88 | 7 | 326118 | 49 | 50278950 |
Back pain | 14.08 | 9.88 | 1622 | 324503 | 218408 | 50060591 |
Bacteraemia | 13.94 | 9.88 | 47 | 326078 | 14386 | 50264613 |
Hypertension | 13.93 | 9.88 | 1560 | 324565 | 209643 | 50069356 |
Hypocapnia | 13.85 | 9.88 | 14 | 326111 | 335 | 50278664 |
Blue toe syndrome | 13.81 | 9.88 | 15 | 326110 | 391 | 50278608 |
Faeces pale | 13.77 | 9.88 | 30 | 326095 | 1461 | 50277538 |
Hypoacusis | 13.77 | 9.88 | 198 | 325927 | 20449 | 50258550 |
Jaundice hepatocellular | 13.75 | 9.88 | 6 | 326119 | 30 | 50278969 |
Sedation complication | 13.75 | 9.88 | 22 | 326103 | 8744 | 50270255 |
Onychomadesis | 13.71 | 9.88 | 3 | 326122 | 3533 | 50275466 |
Joint range of motion decreased | 13.65 | 9.88 | 67 | 326058 | 18445 | 50260554 |
Disorientation | 13.62 | 9.88 | 312 | 325813 | 35172 | 50243827 |
Hypertensive angiopathy | 13.57 | 9.88 | 8 | 326117 | 82 | 50278917 |
Tobacco abuse | 13.55 | 9.88 | 18 | 326107 | 582 | 50278417 |
Palmar-plantar erythrodysaesthesia syndrome | 13.55 | 9.88 | 75 | 326050 | 20023 | 50258976 |
Arteriosclerosis coronary artery | 13.55 | 9.88 | 90 | 326035 | 7546 | 50271453 |
Ligament sprain | 13.55 | 9.88 | 115 | 326010 | 10410 | 50268589 |
Cardio-respiratory arrest | 13.54 | 9.88 | 255 | 325870 | 53637 | 50225362 |
Administration site discomfort | 13.49 | 9.88 | 8 | 326117 | 83 | 50278916 |
Device deployment issue | 13.48 | 9.88 | 3 | 326122 | 3493 | 50275506 |
Bladder sphincter atony | 13.48 | 9.88 | 10 | 326115 | 155 | 50278844 |
Biliary fibrosis | 13.46 | 9.88 | 4 | 326121 | 4 | 50278995 |
Copper metabolism disorder | 13.46 | 9.88 | 4 | 326121 | 4 | 50278995 |
Multiple injuries | 13.43 | 9.88 | 32 | 326093 | 1654 | 50277345 |
Hypophagia | 13.33 | 9.88 | 252 | 325873 | 27476 | 50251523 |
Cardiac operation | 13.31 | 9.88 | 44 | 326081 | 2751 | 50276248 |
Staphylococcal infection | 13.29 | 9.88 | 156 | 325969 | 35460 | 50243539 |
Peripheral vascular disorder | 13.29 | 9.88 | 70 | 326055 | 5397 | 50273602 |
Cytokine release syndrome | 13.23 | 9.88 | 22 | 326103 | 8612 | 50270387 |
Cerebral mass effect | 13.22 | 9.88 | 21 | 326104 | 801 | 50278198 |
Internal haemorrhage | 13.21 | 9.88 | 60 | 326065 | 4357 | 50274642 |
Hypotension | 13.14 | 9.88 | 1721 | 324404 | 233748 | 50045251 |
Blood calcium increased | 13.11 | 9.88 | 90 | 326035 | 7629 | 50271370 |
Flushing | 13.11 | 9.88 | 330 | 325795 | 66685 | 50212314 |
Hypertensive crisis | 13.06 | 9.88 | 136 | 325989 | 13018 | 50265981 |
Vascular purpura | 13.05 | 9.88 | 26 | 326099 | 1188 | 50277811 |
Neutropenic sepsis | 13.03 | 9.88 | 47 | 326078 | 14100 | 50264899 |
High density lipoprotein abnormal | 13.03 | 9.88 | 7 | 326118 | 59 | 50278940 |
Ecchymosis | 13.03 | 9.88 | 111 | 326014 | 10058 | 50268941 |
Ventricular internal diameter abnormal | 13.00 | 9.88 | 6 | 326119 | 35 | 50278964 |
Skin necrosis | 12.97 | 9.88 | 32 | 326093 | 10835 | 50268164 |
Adverse event | 12.96 | 9.88 | 201 | 325924 | 43562 | 50235437 |
Colitis ischaemic | 12.95 | 9.88 | 105 | 326020 | 9378 | 50269621 |
Bronchopulmonary aspergillosis | 12.93 | 9.88 | 18 | 326107 | 7574 | 50271425 |
Tubulointerstitial nephritis and uveitis syndrome | 12.90 | 9.88 | 10 | 326115 | 166 | 50278833 |
Immune reconstitution inflammatory syndrome | 12.87 | 9.88 | 10 | 326115 | 5506 | 50273493 |
Prevertebral soft tissue swelling of cervical space | 12.86 | 9.88 | 6 | 326119 | 36 | 50278963 |
Injection site rash | 12.84 | 9.88 | 57 | 326068 | 16120 | 50262879 |
Xanthelasma | 12.84 | 9.88 | 7 | 326118 | 61 | 50278938 |
Low density lipoprotein decreased | 12.83 | 9.88 | 11 | 326114 | 212 | 50278787 |
Mixed anxiety and depressive disorder | 12.80 | 9.88 | 10 | 326115 | 168 | 50278831 |
Sinus node dysfunction | 12.79 | 9.88 | 55 | 326070 | 3900 | 50275099 |
Neoplasm progression | 12.79 | 9.88 | 123 | 326002 | 29034 | 50249965 |
Lipids abnormal | 12.76 | 9.88 | 12 | 326113 | 262 | 50278737 |
Cardiac pacemaker insertion | 12.75 | 9.88 | 52 | 326073 | 3601 | 50275398 |
Renovascular hypertension | 12.74 | 9.88 | 5 | 326120 | 18 | 50278981 |
Gait deviation | 12.74 | 9.88 | 7 | 326118 | 62 | 50278937 |
Weight increased | 12.69 | 9.88 | 1124 | 325001 | 200767 | 50078232 |
Hypergammaglobulinaemia | 12.69 | 9.88 | 15 | 326110 | 430 | 50278569 |
Cerebral ischaemia | 12.59 | 9.88 | 73 | 326052 | 5835 | 50273164 |
Ageusia | 12.58 | 9.88 | 122 | 326003 | 11461 | 50267538 |
Inclusion body myositis | 12.58 | 9.88 | 4 | 326121 | 6 | 50278993 |
Blood iron abnormal | 12.54 | 9.88 | 3 | 326122 | 3323 | 50275676 |
Myoglobinaemia | 12.53 | 9.88 | 5 | 326120 | 19 | 50278980 |
Ear infection | 12.50 | 9.88 | 107 | 326018 | 25863 | 50253136 |
Nail bed inflammation | 12.50 | 9.88 | 14 | 326111 | 378 | 50278621 |
Blood potassium increased | 12.47 | 9.88 | 161 | 325964 | 16237 | 50262762 |
Parkinsonian rest tremor | 12.44 | 9.88 | 8 | 326117 | 97 | 50278902 |
Wrong dose | 12.39 | 9.88 | 21 | 326104 | 846 | 50278153 |
IIIrd nerve paresis | 12.38 | 9.88 | 9 | 326116 | 135 | 50278864 |
Diverticulum oesophageal | 12.32 | 9.88 | 9 | 326116 | 136 | 50278863 |
Eyelid retraction | 12.10 | 9.88 | 6 | 326119 | 42 | 50278957 |
Parkinsonism | 12.10 | 9.88 | 98 | 326027 | 8749 | 50270250 |
Soft tissue disorder | 12.10 | 9.88 | 6 | 326119 | 4208 | 50274791 |
Lung hyperinflation | 12.08 | 9.88 | 24 | 326101 | 1094 | 50277905 |
N-terminal prohormone brain natriuretic peptide increased | 12.08 | 9.88 | 31 | 326094 | 1679 | 50277320 |
Hypomania | 12.08 | 9.88 | 7 | 326118 | 4498 | 50274501 |
Retroperitoneal haematoma | 12.05 | 9.88 | 41 | 326084 | 2602 | 50276397 |
Acute respiratory distress syndrome | 12.01 | 9.88 | 83 | 326042 | 21016 | 50257983 |
Chest discomfort | 11.98 | 9.88 | 721 | 325404 | 92001 | 50186998 |
Mammogram abnormal | 11.98 | 9.88 | 18 | 326107 | 654 | 50278345 |
Muscle contracture | 11.97 | 9.88 | 25 | 326100 | 1182 | 50277817 |
Fear of injection | 11.94 | 9.88 | 13 | 326112 | 6090 | 50272909 |
Ascites | 11.92 | 9.88 | 161 | 325964 | 35700 | 50243299 |
Cholecystitis chronic | 11.92 | 9.88 | 28 | 326097 | 9641 | 50269358 |
Posture abnormal | 11.90 | 9.88 | 35 | 326090 | 2054 | 50276945 |
Muscle haemorrhage | 11.87 | 9.88 | 44 | 326081 | 2914 | 50276085 |
Hyponatraemic seizure | 11.82 | 9.88 | 14 | 326111 | 402 | 50278597 |
Serotonin syndrome | 11.82 | 9.88 | 102 | 326023 | 24611 | 50254388 |
Albumin urine present | 11.82 | 9.88 | 11 | 326114 | 237 | 50278762 |
Intra-abdominal haematoma | 11.81 | 9.88 | 29 | 326096 | 1528 | 50277471 |
Genital haemorrhage | 11.79 | 9.88 | 15 | 326110 | 6559 | 50272440 |
Lipohypertrophy | 11.76 | 9.88 | 17 | 326108 | 596 | 50278403 |
Narrow anterior chamber angle | 11.76 | 9.88 | 6 | 326119 | 45 | 50278954 |
Neurofibrosarcoma | 11.73 | 9.88 | 9 | 326116 | 147 | 50278852 |
Granulomatous dermatitis | 11.71 | 9.88 | 8 | 326117 | 108 | 50278891 |
Electrocardiogram Q wave abnormal | 11.69 | 9.88 | 7 | 326118 | 74 | 50278925 |
Adenovirus infection | 11.66 | 9.88 | 3 | 326122 | 3165 | 50275834 |
Basal ganglia haemorrhage | 11.66 | 9.88 | 16 | 326109 | 534 | 50278465 |
Parapsoriasis | 11.65 | 9.88 | 8 | 326117 | 109 | 50278890 |
Anal polyp | 11.65 | 9.88 | 6 | 326119 | 46 | 50278953 |
Crystal urine | 11.65 | 9.88 | 6 | 326119 | 46 | 50278953 |
White blood cell count decreased | 11.63 | 9.88 | 624 | 325501 | 116098 | 50162901 |
Hallucination | 11.62 | 9.88 | 388 | 325737 | 46269 | 50232730 |
Glucose urine present | 11.62 | 9.88 | 18 | 326107 | 672 | 50278327 |
Dilatation atrial | 11.62 | 9.88 | 32 | 326093 | 1809 | 50277190 |
Blood pressure systolic increased | 11.60 | 9.88 | 305 | 325820 | 35144 | 50243855 |
Product complaint | 11.60 | 9.88 | 119 | 326006 | 11347 | 50267652 |
Lipoma | 11.60 | 9.88 | 35 | 326090 | 2084 | 50276915 |
Diabetic foot | 11.58 | 9.88 | 26 | 326099 | 1292 | 50277707 |
Muscle rupture | 11.57 | 9.88 | 35 | 326090 | 2087 | 50276912 |
Eye haemorrhage | 11.57 | 9.88 | 84 | 326041 | 7251 | 50271748 |
Fine motor skill dysfunction | 11.54 | 9.88 | 6 | 326119 | 4097 | 50274902 |
Gastroduodenal haemorrhage | 11.54 | 9.88 | 7 | 326118 | 76 | 50278923 |
Injury | 11.53 | 9.88 | 234 | 325891 | 48691 | 50230308 |
Cardiac discomfort | 11.52 | 9.88 | 20 | 326105 | 822 | 50278177 |
Dyslipidaemia | 11.50 | 9.88 | 72 | 326053 | 5916 | 50273083 |
Respiratory disorder | 11.49 | 9.88 | 137 | 325988 | 31050 | 50247949 |
Vascular device infection | 11.49 | 9.88 | 7 | 326118 | 4377 | 50274622 |
Deformity | 11.47 | 9.88 | 21 | 326104 | 7919 | 50271080 |
Lacunar stroke | 11.47 | 9.88 | 8 | 326117 | 112 | 50278887 |
Blood calcitonin increased | 11.46 | 9.88 | 5 | 326120 | 25 | 50278974 |
Vascular graft | 11.45 | 9.88 | 19 | 326106 | 752 | 50278247 |
Iron deficiency anaemia | 11.45 | 9.88 | 162 | 325963 | 16672 | 50262327 |
Polyarthritis | 11.42 | 9.88 | 21 | 326104 | 7906 | 50271093 |
Incision site haemorrhage | 11.41 | 9.88 | 15 | 326110 | 480 | 50278519 |
Acute respiratory failure | 11.34 | 9.88 | 254 | 325871 | 28528 | 50250471 |
Acute pulmonary oedema | 11.33 | 9.88 | 83 | 326042 | 7184 | 50271815 |
Swelling face | 11.27 | 9.88 | 430 | 325695 | 52165 | 50226834 |
Carotid bruit | 11.24 | 9.88 | 17 | 326108 | 621 | 50278378 |
BRASH syndrome | 11.23 | 9.88 | 10 | 326115 | 203 | 50278796 |
Dairy intolerance | 11.23 | 9.88 | 6 | 326119 | 50 | 50278949 |
Myeloma cast nephropathy | 11.17 | 9.88 | 8 | 326117 | 117 | 50278882 |
Tunnel vision | 11.06 | 9.88 | 18 | 326107 | 701 | 50278298 |
Lymphomatoid papulosis | 11.06 | 9.88 | 8 | 326117 | 119 | 50278880 |
Body temperature increased | 11.04 | 9.88 | 139 | 325986 | 31202 | 50247797 |
Acute cutaneous lupus erythematosus | 11.02 | 9.88 | 11 | 326114 | 259 | 50278740 |
Prolonged expiration | 11.02 | 9.88 | 18 | 326107 | 703 | 50278296 |
Myelodysplastic syndrome | 11.02 | 9.88 | 55 | 326070 | 15077 | 50263922 |
Arterial disorder | 11.02 | 9.88 | 22 | 326103 | 1007 | 50277992 |
Palpitations | 10.95 | 9.88 | 728 | 325397 | 93778 | 50185221 |
Cataract operation | 10.95 | 9.88 | 54 | 326071 | 4057 | 50274942 |
Pulmonary oedema | 10.95 | 9.88 | 402 | 325723 | 48536 | 50230463 |
Dementia Alzheimer's type | 10.94 | 9.88 | 22 | 326103 | 1012 | 50277987 |
Connective tissue inflammation | 10.93 | 9.88 | 6 | 326119 | 53 | 50278946 |
Hyperprolactinaemia | 10.93 | 9.88 | 4 | 326121 | 3361 | 50275638 |
Vascular stenosis | 10.92 | 9.88 | 11 | 326114 | 262 | 50278737 |
Lymphadenopathy | 10.91 | 9.88 | 151 | 325974 | 33348 | 50245651 |
Bifascicular block | 10.89 | 9.88 | 8 | 326117 | 122 | 50278877 |
Atrial flutter | 10.89 | 9.88 | 95 | 326030 | 8668 | 50270331 |
Binocular eye movement disorder | 10.86 | 9.88 | 5 | 326120 | 29 | 50278970 |
Pneumocystis jirovecii pneumonia | 10.85 | 9.88 | 53 | 326072 | 14610 | 50264389 |
Gouty arthritis | 10.83 | 9.88 | 15 | 326110 | 505 | 50278494 |
Exercise tolerance increased | 10.72 | 9.88 | 5 | 326120 | 30 | 50278969 |
Primary biliary cholangitis | 10.71 | 9.88 | 23 | 326102 | 1109 | 50277890 |
Shock haemorrhagic | 10.65 | 9.88 | 91 | 326034 | 8253 | 50270746 |
Maternal exposure timing unspecified | 10.63 | 9.88 | 5 | 326120 | 3615 | 50275384 |
Post transplant lymphoproliferative disorder | 10.62 | 9.88 | 7 | 326118 | 4197 | 50274802 |
Vaginal haemorrhage | 10.59 | 9.88 | 104 | 326021 | 24447 | 50254552 |
Tenderness | 10.58 | 9.88 | 73 | 326052 | 18492 | 50260507 |
Cardiogenic shock | 10.56 | 9.88 | 150 | 325975 | 15449 | 50263550 |
Hyperthermia | 10.55 | 9.88 | 21 | 326104 | 7675 | 50271324 |
Accelerated hypertension | 10.51 | 9.88 | 13 | 326112 | 391 | 50278608 |
Inappropriate schedule of product discontinuation | 10.50 | 9.88 | 4 | 326121 | 13 | 50278986 |
Renal artery stenosis | 10.49 | 9.88 | 29 | 326096 | 1643 | 50277356 |
Nausea | 10.42 | 9.88 | 4855 | 321270 | 700543 | 49578456 |
End stage renal disease | 10.41 | 9.88 | 68 | 326057 | 5669 | 50273330 |
Aortic valve replacement | 10.37 | 9.88 | 17 | 326108 | 666 | 50278333 |
Pneumonia aspiration | 10.37 | 9.88 | 139 | 325986 | 30865 | 50248134 |
Malignant polyp | 10.34 | 9.88 | 9 | 326116 | 177 | 50278822 |
Urinary straining | 10.33 | 9.88 | 5 | 326120 | 33 | 50278966 |
Alanine aminotransferase | 10.31 | 9.88 | 6 | 326119 | 60 | 50278939 |
Cholelithiasis | 10.29 | 9.88 | 319 | 325806 | 37654 | 50241345 |
Unintended pregnancy | 10.28 | 9.88 | 10 | 326115 | 4936 | 50274063 |
Alpha hydroxybutyrate dehydrogenase increased | 10.28 | 9.88 | 4 | 326121 | 14 | 50278985 |
Cardiac valve disease | 10.27 | 9.88 | 50 | 326075 | 3736 | 50275263 |
Noninfectious peritonitis | 10.26 | 9.88 | 8 | 326117 | 134 | 50278865 |
Complication associated with device | 10.26 | 9.88 | 54 | 326071 | 14601 | 50264398 |
Arrhythmia | 10.25 | 9.88 | 283 | 325842 | 32849 | 50246150 |
Tendon rupture | 10.24 | 9.88 | 80 | 326045 | 7064 | 50271935 |
Ocular icterus | 10.24 | 9.88 | 47 | 326078 | 3428 | 50275571 |
Neuroleptic malignant syndrome | 10.24 | 9.88 | 37 | 326088 | 11093 | 50267906 |
Collagen disorder | 10.22 | 9.88 | 9 | 326116 | 180 | 50278819 |
Vitrectomy | 10.21 | 9.88 | 8 | 326117 | 135 | 50278864 |
Bundle branch block left | 10.20 | 9.88 | 72 | 326053 | 6158 | 50272841 |
Scleritis | 10.20 | 9.88 | 4 | 326121 | 3223 | 50275776 |
Intracranial haematoma | 10.18 | 9.88 | 12 | 326113 | 343 | 50278656 |
Aggression | 10.17 | 9.88 | 87 | 326038 | 21029 | 50257970 |
Fungal infection | 10.15 | 9.88 | 134 | 325991 | 29831 | 50249168 |
Haemorrhagic stroke | 10.12 | 9.88 | 63 | 326062 | 5165 | 50273834 |
Drug ineffective for unapproved indication | 10.10 | 9.88 | 88 | 326037 | 21193 | 50257806 |
Fructosamine increased | 10.09 | 9.88 | 3 | 326122 | 3 | 50278996 |
Autoimmune encephalopathy | 10.09 | 9.88 | 3 | 326122 | 3 | 50278996 |
Abdominal wall mass | 10.09 | 9.88 | 3 | 326122 | 3 | 50278996 |
Juvenile idiopathic arthritis | 10.09 | 9.88 | 3 | 326122 | 2876 | 50276123 |
Laryngotracheal oedema | 10.08 | 9.88 | 5 | 326120 | 35 | 50278964 |
Renal cell carcinoma stage IV | 10.07 | 9.88 | 4 | 326121 | 15 | 50278984 |
Atrial pressure increased | 10.07 | 9.88 | 4 | 326121 | 15 | 50278984 |
Mitral valve stenosis | 10.05 | 9.88 | 21 | 326104 | 993 | 50278006 |
Coeliac disease | 10.04 | 9.88 | 26 | 326099 | 8659 | 50270340 |
Gastritis erosive | 10.03 | 9.88 | 62 | 326063 | 5072 | 50273927 |
Blood glucose fluctuation | 10.02 | 9.88 | 53 | 326072 | 4093 | 50274906 |
Heart sounds | 10.00 | 9.88 | 16 | 326109 | 614 | 50278385 |
Gastric ulcer haemorrhage | 9.95 | 9.88 | 56 | 326069 | 4428 | 50274571 |
Supraventricular extrasystoles | 9.94 | 9.88 | 51 | 326074 | 3893 | 50275106 |
Stoma site haemorrhage | 9.93 | 9.88 | 20 | 326105 | 921 | 50278078 |
Hepatic cyst | 9.89 | 9.88 | 56 | 326069 | 4437 | 50274562 |
Type V hyperlipidaemia | 9.89 | 9.88 | 13 | 326112 | 416 | 50278583 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myalgia | 1201.83 | 11.48 | 2555 | 319798 | 71464 | 29180710 |
Immune-mediated myositis | 1124.82 | 11.48 | 479 | 321874 | 1124 | 29251050 |
Rhabdomyolysis | 738.86 | 11.48 | 1874 | 320479 | 58934 | 29193240 |
Toxicity to various agents | 497.74 | 11.48 | 701 | 321652 | 172960 | 29079214 |
Blood creatine phosphokinase increased | 481.34 | 11.48 | 1241 | 321112 | 39403 | 29212771 |
Drug abuse | 479.33 | 11.48 | 138 | 322215 | 79745 | 29172429 |
Off label use | 403.30 | 11.48 | 1799 | 320554 | 299001 | 28953173 |
Febrile neutropenia | 381.77 | 11.48 | 396 | 321957 | 111844 | 29140330 |
Myopathy | 374.53 | 11.48 | 516 | 321837 | 10017 | 29242157 |
Myocardial infarction | 330.20 | 11.48 | 2195 | 320158 | 108101 | 29144073 |
Foetal exposure during pregnancy | 326.92 | 11.48 | 9 | 322344 | 33858 | 29218316 |
Necrotising myositis | 325.14 | 11.48 | 140 | 322213 | 341 | 29251833 |
Drug ineffective | 267.61 | 11.48 | 2602 | 319751 | 360568 | 28891606 |
Coronary artery disease | 240.37 | 11.48 | 1037 | 321316 | 43153 | 29209021 |
Completed suicide | 231.55 | 11.48 | 392 | 321961 | 89854 | 29162320 |
Neutropenia | 230.80 | 11.48 | 704 | 321649 | 131007 | 29121167 |
Pyrexia | 219.03 | 11.48 | 2043 | 320310 | 285579 | 28966595 |
Drug hypersensitivity | 199.41 | 11.48 | 1353 | 321000 | 67053 | 29185121 |
Cerebrovascular accident | 195.66 | 11.48 | 1472 | 320881 | 75439 | 29176735 |
Acute myocardial infarction | 168.97 | 11.48 | 1003 | 321350 | 47435 | 29204739 |
Premature baby | 161.72 | 11.48 | 6 | 322347 | 17274 | 29234900 |
Angina pectoris | 157.92 | 11.48 | 662 | 321691 | 27188 | 29224986 |
Muscular weakness | 144.67 | 11.48 | 1164 | 321189 | 60888 | 29191286 |
Dizziness | 139.13 | 11.48 | 2868 | 319485 | 186816 | 29065358 |
Chest pain | 134.80 | 11.48 | 1836 | 320517 | 110137 | 29142037 |
Low density lipoprotein increased | 133.90 | 11.48 | 188 | 322165 | 3716 | 29248458 |
Acute kidney injury | 126.99 | 11.48 | 3785 | 318568 | 261482 | 28990692 |
Drug resistance | 125.83 | 11.48 | 39 | 322314 | 21501 | 29230673 |
Treatment failure | 124.65 | 11.48 | 131 | 322222 | 36808 | 29215366 |
Coronary artery stenosis | 124.09 | 11.48 | 283 | 322070 | 8290 | 29243884 |
Mucosal inflammation | 123.31 | 11.48 | 98 | 322255 | 31497 | 29220677 |
Polymyositis | 119.54 | 11.48 | 106 | 322247 | 1222 | 29250952 |
Malignant neoplasm progression | 115.29 | 11.48 | 415 | 321938 | 73444 | 29178730 |
Bone marrow failure | 115.06 | 11.48 | 79 | 322274 | 27370 | 29224804 |
Coronary artery occlusion | 114.04 | 11.48 | 303 | 322050 | 9791 | 29242383 |
Muscle rupture | 113.53 | 11.48 | 124 | 322229 | 1873 | 29250301 |
Product use in unapproved indication | 109.03 | 11.48 | 531 | 321822 | 86344 | 29165830 |
Death | 108.09 | 11.48 | 2872 | 319481 | 339212 | 28912962 |
Muscle spasms | 107.64 | 11.48 | 1134 | 321219 | 63948 | 29188226 |
Cytomegalovirus infection | 105.31 | 11.48 | 61 | 322292 | 23154 | 29229020 |
Transient ischaemic attack | 99.98 | 11.48 | 510 | 321843 | 22760 | 29229414 |
Pancytopenia | 96.08 | 11.48 | 523 | 321830 | 82645 | 29169529 |
White blood cell count decreased | 95.87 | 11.48 | 525 | 321828 | 82837 | 29169337 |
Pneumonia | 91.36 | 11.48 | 2726 | 319627 | 317446 | 28934728 |
High density lipoprotein decreased | 91.28 | 11.48 | 136 | 322217 | 2843 | 29249331 |
Platelet count decreased | 91.13 | 11.48 | 717 | 321636 | 103955 | 29148219 |
Leukopenia | 89.60 | 11.48 | 305 | 322048 | 54898 | 29197276 |
Angina unstable | 88.20 | 11.48 | 290 | 322063 | 10575 | 29241599 |
Sepsis | 87.33 | 11.48 | 1065 | 321288 | 141617 | 29110557 |
Acute coronary syndrome | 86.14 | 11.48 | 313 | 322040 | 12012 | 29240162 |
Ischaemic stroke | 84.56 | 11.48 | 372 | 321981 | 15605 | 29236569 |
Thrombocytopenia | 84.54 | 11.48 | 1001 | 321352 | 133822 | 29118352 |
Neutrophil count decreased | 84.17 | 11.48 | 222 | 322131 | 43345 | 29208829 |
Graft versus host disease | 81.79 | 11.48 | 6 | 322347 | 9622 | 29242552 |
Tendon rupture | 81.54 | 11.48 | 199 | 322154 | 6096 | 29246078 |
Mitral valve incompetence | 80.88 | 11.48 | 323 | 322030 | 12970 | 29239204 |
Dyspnoea | 79.89 | 11.48 | 4337 | 318016 | 322395 | 28929779 |
Blood cholesterol increased | 78.69 | 11.48 | 358 | 321995 | 15237 | 29236937 |
Drug dependence | 78.25 | 11.48 | 68 | 322285 | 20913 | 29231261 |
Respiratory depression | 78.06 | 11.48 | 25 | 322328 | 13498 | 29238676 |
Autoimmune myositis | 76.37 | 11.48 | 31 | 322322 | 61 | 29252113 |
Atrial fibrillation | 75.49 | 11.48 | 1592 | 320761 | 104054 | 29148120 |
Syncope | 75.28 | 11.48 | 1276 | 321077 | 80095 | 29172079 |
Product monitoring error | 74.34 | 11.48 | 116 | 322237 | 2529 | 29249645 |
Exposure during pregnancy | 73.62 | 11.48 | 5 | 322348 | 8549 | 29243625 |
Erectile dysfunction | 71.37 | 11.48 | 386 | 321967 | 17623 | 29234551 |
Stomatitis | 70.26 | 11.48 | 191 | 322162 | 36922 | 29215252 |
Respiratory arrest | 68.23 | 11.48 | 110 | 322243 | 25723 | 29226451 |
Low density lipoprotein decreased | 68.09 | 11.48 | 69 | 322284 | 951 | 29251223 |
Overdose | 67.94 | 11.48 | 550 | 321803 | 79269 | 29172905 |
Ascites | 67.43 | 11.48 | 191 | 322162 | 36428 | 29215746 |
Blood triglycerides increased | 67.29 | 11.48 | 298 | 322055 | 12536 | 29239638 |
Intentional self-injury | 66.86 | 11.48 | 26 | 322327 | 12435 | 29239739 |
Pneumocystis jirovecii pneumonia | 66.78 | 11.48 | 51 | 322302 | 16728 | 29235446 |
Muscle disorder | 66.63 | 11.48 | 101 | 322252 | 2145 | 29250029 |
Infusion related reaction | 64.92 | 11.48 | 252 | 322101 | 43634 | 29208540 |
Product use issue | 64.75 | 11.48 | 314 | 322039 | 51130 | 29201044 |
Vascular stent thrombosis | 64.54 | 11.48 | 108 | 322245 | 2502 | 29249672 |
Suicide attempt | 64.23 | 11.48 | 176 | 322177 | 33934 | 29218240 |
Amnesia | 63.60 | 11.48 | 444 | 321909 | 22199 | 29229975 |
Type 2 diabetes mellitus | 63.55 | 11.48 | 305 | 322048 | 13276 | 29238898 |
Myositis | 63.47 | 11.48 | 251 | 322102 | 10032 | 29242142 |
Muscle necrosis | 61.97 | 11.48 | 59 | 322294 | 750 | 29251424 |
Intentional overdose | 60.40 | 11.48 | 216 | 322137 | 38312 | 29213862 |
Poisoning | 60.36 | 11.48 | 17 | 322336 | 9976 | 29242198 |
Myelosuppression | 60.06 | 11.48 | 29 | 322324 | 12198 | 29239976 |
Disseminated intravascular coagulation | 59.72 | 11.48 | 78 | 322275 | 19902 | 29232272 |
Low birth weight baby | 59.50 | 11.48 | 3 | 322350 | 6605 | 29245569 |
Myopathy toxic | 58.59 | 11.48 | 44 | 322309 | 393 | 29251781 |
Hypomagnesaemia | 58.49 | 11.48 | 358 | 321995 | 17110 | 29235064 |
Bronchopulmonary aspergillosis | 58.06 | 11.48 | 31 | 322322 | 12313 | 29239861 |
Multiple organ dysfunction syndrome | 57.88 | 11.48 | 426 | 321927 | 62690 | 29189484 |
Asthenia | 57.87 | 11.48 | 2884 | 319469 | 212366 | 29039808 |
Muscle atrophy | 56.75 | 11.48 | 178 | 322175 | 6328 | 29245846 |
Disease progression | 56.10 | 11.48 | 596 | 321757 | 81320 | 29170854 |
Respiratory failure | 55.28 | 11.48 | 736 | 321617 | 96395 | 29155779 |
Pain in extremity | 55.10 | 11.48 | 1585 | 320768 | 108848 | 29143326 |
Inferior vena cava dilatation | 54.97 | 11.48 | 51 | 322302 | 626 | 29251548 |
Haemophagocytic lymphohistiocytosis | 54.59 | 11.48 | 23 | 322330 | 10481 | 29241693 |
Dyspnoea exertional | 54.40 | 11.48 | 623 | 321730 | 35867 | 29216307 |
Diabetic ketoacidosis | 54.19 | 11.48 | 330 | 322023 | 15743 | 29236431 |
Aspergillus infection | 53.67 | 11.48 | 24 | 322329 | 10557 | 29241617 |
Immune reconstitution inflammatory syndrome | 53.64 | 11.48 | 10 | 322343 | 7792 | 29244382 |
Cardiac failure | 53.14 | 11.48 | 1184 | 321169 | 78103 | 29174071 |
Serotonin syndrome | 52.72 | 11.48 | 68 | 322285 | 17444 | 29234730 |
Pathogen resistance | 52.50 | 11.48 | 12 | 322341 | 8104 | 29244070 |
Rectal haemorrhage | 52.46 | 11.48 | 592 | 321761 | 33957 | 29218217 |
Haematuria | 51.88 | 11.48 | 721 | 321632 | 43418 | 29208756 |
Drug interaction | 51.66 | 11.48 | 2638 | 319715 | 194747 | 29057427 |
Fall | 51.18 | 11.48 | 2391 | 319962 | 174787 | 29077387 |
Septic shock | 50.99 | 11.48 | 436 | 321917 | 62124 | 29190050 |
Labelled drug-drug interaction medication error | 49.80 | 11.48 | 263 | 322090 | 11896 | 29240278 |
Cytokine release syndrome | 49.55 | 11.48 | 42 | 322311 | 13077 | 29239097 |
Intentional product misuse | 49.37 | 11.48 | 202 | 322151 | 34459 | 29217715 |
Posterior reversible encephalopathy syndrome | 49.37 | 11.48 | 18 | 322335 | 8958 | 29243216 |
Cardiac failure chronic | 49.29 | 11.48 | 169 | 322184 | 6298 | 29245876 |
Presyncope | 49.07 | 11.48 | 322 | 322031 | 15767 | 29236407 |
Infection | 47.98 | 11.48 | 570 | 321783 | 76181 | 29175993 |
Chromaturia | 47.79 | 11.48 | 270 | 322083 | 12532 | 29239642 |
Myocardial necrosis marker increased | 47.38 | 11.48 | 70 | 322283 | 1452 | 29250722 |
Glycosylated haemoglobin increased | 47.26 | 11.48 | 216 | 322137 | 9210 | 29242964 |
Cardiac disorder | 46.80 | 11.48 | 616 | 321737 | 36647 | 29215527 |
Blood glucose increased | 46.78 | 11.48 | 903 | 321450 | 58081 | 29194093 |
Psoriasis | 46.60 | 11.48 | 547 | 321806 | 31680 | 29220494 |
Muscle injury | 46.37 | 11.48 | 60 | 322293 | 1093 | 29251081 |
Bradycardia | 46.18 | 11.48 | 987 | 321366 | 64642 | 29187532 |
Hypertensive emergency | 45.95 | 11.48 | 51 | 322302 | 785 | 29251389 |
Intentional product use issue | 45.93 | 11.48 | 273 | 322080 | 42225 | 29209949 |
C-reactive protein abnormal | 45.75 | 11.48 | 8 | 322345 | 6528 | 29245646 |
Seizure | 45.52 | 11.48 | 727 | 321626 | 92396 | 29159778 |
Oedema peripheral | 45.14 | 11.48 | 1462 | 320891 | 102095 | 29150079 |
Upper gastrointestinal haemorrhage | 44.62 | 11.48 | 399 | 321954 | 21515 | 29230659 |
Product prescribing error | 44.47 | 11.48 | 342 | 322011 | 17634 | 29234540 |
Dermatomyositis | 44.45 | 11.48 | 56 | 322297 | 992 | 29251182 |
Restlessness | 43.40 | 11.48 | 112 | 322241 | 22033 | 29230141 |
Amyotrophic lateral sclerosis | 43.30 | 11.48 | 51 | 322302 | 840 | 29251334 |
Ejection fraction decreased | 42.94 | 11.48 | 310 | 322043 | 15668 | 29236506 |
Ventricular hypokinesia | 42.71 | 11.48 | 128 | 322225 | 4437 | 29247737 |
Neurotoxicity | 42.70 | 11.48 | 58 | 322295 | 14555 | 29237619 |
Epstein-Barr virus infection | 42.48 | 11.48 | 10 | 322343 | 6619 | 29245555 |
Product substitution issue | 42.20 | 11.48 | 205 | 322148 | 8967 | 29243207 |
Atrial septal defect | 42.04 | 11.48 | 11 | 322342 | 6778 | 29245396 |
Acute myeloid leukaemia | 42.04 | 11.48 | 72 | 322281 | 16441 | 29235733 |
Hyperkalaemia | 41.82 | 11.48 | 919 | 321434 | 60473 | 29191701 |
Faeces discoloured | 41.82 | 11.48 | 269 | 322084 | 13082 | 29239092 |
Ischaemic cardiomyopathy | 41.80 | 11.48 | 146 | 322207 | 5492 | 29246682 |
Hepatic encephalopathy | 40.93 | 11.48 | 49 | 322304 | 12986 | 29239188 |
Therapeutic product effect incomplete | 40.64 | 11.48 | 256 | 322097 | 39049 | 29213125 |
Muscle enzyme increased | 40.47 | 11.48 | 28 | 322325 | 217 | 29251957 |
Lactic acidosis | 40.08 | 11.48 | 505 | 321848 | 29742 | 29222432 |
N-terminal prohormone brain natriuretic peptide increased | 40.06 | 11.48 | 74 | 322279 | 1858 | 29250316 |
Agitation | 39.84 | 11.48 | 362 | 321991 | 50942 | 29201232 |
Melaena | 39.82 | 11.48 | 517 | 321836 | 30659 | 29221515 |
Arteriosclerosis | 39.41 | 11.48 | 218 | 322135 | 10038 | 29242136 |
Haematotoxicity | 39.35 | 11.48 | 12 | 322341 | 6687 | 29245487 |
Myocardial ischaemia | 39.13 | 11.48 | 304 | 322049 | 15724 | 29236450 |
Low density lipoprotein abnormal | 38.78 | 11.48 | 28 | 322325 | 234 | 29251940 |
Glomerular filtration rate decreased | 38.42 | 11.48 | 232 | 322121 | 11034 | 29241140 |
Progressive multifocal leukoencephalopathy | 38.01 | 11.48 | 24 | 322329 | 8695 | 29243479 |
Akathisia | 37.97 | 11.48 | 13 | 322340 | 6729 | 29245445 |
Neuroleptic malignant syndrome | 37.91 | 11.48 | 74 | 322279 | 16074 | 29236100 |
Post transplant lymphoproliferative disorder | 37.85 | 11.48 | 7 | 322346 | 5486 | 29246688 |
Carotid artery stenosis | 37.82 | 11.48 | 121 | 322232 | 4348 | 29247826 |
Coma | 37.25 | 11.48 | 264 | 322089 | 39186 | 29212988 |
Exercise lack of | 36.33 | 11.48 | 20 | 322333 | 97 | 29252077 |
Cystitis haemorrhagic | 36.00 | 11.48 | 5 | 322348 | 4837 | 29247337 |
Cardiac failure congestive | 35.95 | 11.48 | 1091 | 321262 | 75490 | 29176684 |
Hypoglycaemia | 35.93 | 11.48 | 733 | 321620 | 47613 | 29204561 |
Arteriosclerosis coronary artery | 35.91 | 11.48 | 218 | 322135 | 10387 | 29241787 |
Tumour lysis syndrome | 35.84 | 11.48 | 60 | 322293 | 13824 | 29238350 |
Bacteraemia | 35.61 | 11.48 | 78 | 322275 | 16245 | 29235929 |
Vomiting | 35.24 | 11.48 | 1923 | 320430 | 210337 | 29041837 |
Heart rate irregular | 34.96 | 11.48 | 254 | 322099 | 12863 | 29239311 |
Computerised tomogram coronary artery abnormal | 34.90 | 11.48 | 24 | 322329 | 184 | 29251990 |
Pancreatitis acute | 34.85 | 11.48 | 413 | 321940 | 23972 | 29228202 |
Cardio-respiratory arrest | 34.69 | 11.48 | 368 | 321985 | 50233 | 29201941 |
Hepatitis cholestatic | 34.59 | 11.48 | 158 | 322195 | 6735 | 29245439 |
Blood cholesterol decreased | 34.53 | 11.48 | 47 | 322306 | 901 | 29251273 |
Condition aggravated | 33.90 | 11.48 | 1278 | 321075 | 145017 | 29107157 |
Diabetic nephropathy | 33.68 | 11.48 | 68 | 322285 | 1827 | 29250347 |
Neoplasm progression | 33.58 | 11.48 | 98 | 322255 | 18514 | 29233660 |
Muscle fatigue | 33.52 | 11.48 | 53 | 322300 | 1169 | 29251005 |
Nocturia | 32.97 | 11.48 | 179 | 322174 | 8183 | 29243991 |
Drug withdrawal syndrome | 32.95 | 11.48 | 94 | 322259 | 17890 | 29234284 |
Coronary artery bypass | 32.75 | 11.48 | 119 | 322234 | 4566 | 29247608 |
Hepatocellular injury | 32.69 | 11.48 | 365 | 321988 | 20878 | 29231296 |
Myelodysplastic syndrome | 32.61 | 11.48 | 93 | 322260 | 17701 | 29234473 |
Drug ineffective for unapproved indication | 31.78 | 11.48 | 67 | 322286 | 14147 | 29238027 |
Stent placement | 31.49 | 11.48 | 111 | 322242 | 4195 | 29247979 |
Polymyalgia rheumatica | 31.14 | 11.48 | 51 | 322302 | 1160 | 29251014 |
Genital swelling | 30.65 | 11.48 | 20 | 322333 | 139 | 29252035 |
Troponin increased | 30.61 | 11.48 | 188 | 322165 | 8995 | 29243179 |
Enterococcal infection | 30.58 | 11.48 | 27 | 322326 | 8241 | 29243933 |
Substance abuse | 30.54 | 11.48 | 18 | 322335 | 6769 | 29245405 |
Coronary artery restenosis | 30.38 | 11.48 | 46 | 322307 | 976 | 29251198 |
Hypotension | 30.25 | 11.48 | 2485 | 319868 | 191869 | 29060305 |
Lymphocyte count decreased | 30.22 | 11.48 | 108 | 322245 | 19163 | 29233011 |
Vascular stent stenosis | 30.11 | 11.48 | 46 | 322307 | 984 | 29251190 |
Haematoma | 30.09 | 11.48 | 386 | 321967 | 22826 | 29229348 |
Orthostatic hypotension | 30.06 | 11.48 | 378 | 321975 | 22251 | 29229923 |
Exercise tolerance decreased | 30.03 | 11.48 | 108 | 322245 | 4123 | 29248051 |
Blood creatine phosphokinase MB increased | 29.99 | 11.48 | 62 | 322291 | 1695 | 29250479 |
Blood cholesterol | 29.92 | 11.48 | 21 | 322332 | 167 | 29252007 |
Depressed level of consciousness | 29.85 | 11.48 | 258 | 322095 | 36684 | 29215490 |
Febrile bone marrow aplasia | 29.69 | 11.48 | 22 | 322331 | 7329 | 29244845 |
Maternal exposure during pregnancy | 28.96 | 11.48 | 5 | 322348 | 4118 | 29248056 |
Toxic epidermal necrolysis | 28.96 | 11.48 | 101 | 322252 | 18052 | 29234122 |
Cerebral haemorrhage | 28.73 | 11.48 | 492 | 321861 | 30934 | 29221240 |
Tricuspid valve incompetence | 28.71 | 11.48 | 173 | 322180 | 8221 | 29243953 |
Aggression | 28.37 | 11.48 | 249 | 322104 | 35292 | 29216882 |
Psychotic disorder | 28.13 | 11.48 | 120 | 322233 | 20234 | 29231940 |
Cytomegalovirus viraemia | 28.10 | 11.48 | 17 | 322336 | 6303 | 29245871 |
Intermittent claudication | 27.94 | 11.48 | 66 | 322287 | 1979 | 29250195 |
Palpitations | 27.86 | 11.48 | 505 | 321848 | 32099 | 29220075 |
Mixed liver injury | 27.81 | 11.48 | 66 | 322287 | 1985 | 29250189 |
Therapy partial responder | 27.64 | 11.48 | 11 | 322342 | 5188 | 29246986 |
Haematochezia | 27.57 | 11.48 | 561 | 321792 | 36422 | 29215752 |
Hepatitis C | 27.44 | 11.48 | 34 | 322319 | 8876 | 29243298 |
Diabetes mellitus inadequate control | 27.36 | 11.48 | 226 | 322127 | 11908 | 29240266 |
Liver function test abnormal | 27.26 | 11.48 | 455 | 321898 | 28463 | 29223711 |
Glycogen storage disease type V | 27.12 | 11.48 | 12 | 322341 | 32 | 29252142 |
Tachycardia | 27.06 | 11.48 | 592 | 321761 | 71818 | 29180356 |
Stenosis | 26.98 | 11.48 | 44 | 322309 | 997 | 29251177 |
Drug use disorder | 26.74 | 11.48 | 3 | 322350 | 3419 | 29248755 |
Carotid artery occlusion | 26.71 | 11.48 | 64 | 322289 | 1937 | 29250237 |
Hepatic enzyme increased | 26.63 | 11.48 | 517 | 321836 | 33282 | 29218892 |
Transplant rejection | 26.48 | 11.48 | 37 | 322316 | 9175 | 29242999 |
Blood loss anaemia | 26.30 | 11.48 | 152 | 322201 | 7114 | 29245060 |
Gastrointestinal haemorrhage | 26.14 | 11.48 | 1088 | 321265 | 78445 | 29173729 |
Type V hyperlipidaemia | 26.06 | 11.48 | 35 | 322318 | 662 | 29251512 |
Acute respiratory distress syndrome | 26.03 | 11.48 | 145 | 322208 | 22790 | 29229384 |
Tendonitis | 25.92 | 11.48 | 162 | 322191 | 7799 | 29244375 |
Status epilepticus | 25.74 | 11.48 | 49 | 322304 | 10745 | 29241429 |
Haemorrhagic stroke | 25.60 | 11.48 | 129 | 322224 | 5727 | 29246447 |
Blood cholesterol abnormal | 25.54 | 11.48 | 52 | 322301 | 1406 | 29250768 |
Blood urea abnormal | 25.43 | 11.48 | 36 | 322317 | 717 | 29251457 |
Respiratory distress | 25.15 | 11.48 | 226 | 322127 | 31880 | 29220294 |
Cytopenia | 25.08 | 11.48 | 43 | 322310 | 9816 | 29242358 |
Ventricular enlargement | 24.98 | 11.48 | 28 | 322325 | 436 | 29251738 |
Hepatitis B reactivation | 24.81 | 11.48 | 3 | 322350 | 3226 | 29248948 |
Abnormal behaviour | 24.75 | 11.48 | 149 | 322204 | 22978 | 29229196 |
Pruritus genital | 24.75 | 11.48 | 30 | 322323 | 510 | 29251664 |
Carotid artery disease | 24.70 | 11.48 | 38 | 322315 | 818 | 29251356 |
Degenerative mitral valve disease | 24.50 | 11.48 | 20 | 322333 | 204 | 29251970 |
Cardiac failure acute | 24.50 | 11.48 | 178 | 322175 | 9014 | 29243160 |
Pseudomonas infection | 24.39 | 11.48 | 51 | 322302 | 10801 | 29241373 |
Ocular myasthenia | 24.35 | 11.48 | 20 | 322333 | 206 | 29251968 |
Eye injury | 24.32 | 11.48 | 32 | 322321 | 593 | 29251581 |
Swollen tongue | 24.29 | 11.48 | 222 | 322131 | 12044 | 29240130 |
Encephalopathy | 24.11 | 11.48 | 219 | 322134 | 30824 | 29221350 |
Hyperlipidaemia | 23.99 | 11.48 | 226 | 322127 | 12364 | 29239810 |
Normocytic anaemia | 23.73 | 11.48 | 61 | 322292 | 1931 | 29250243 |
Hepatocellular carcinoma | 23.69 | 11.48 | 25 | 322328 | 7013 | 29245161 |
Hypoalbuminaemia | 23.52 | 11.48 | 48 | 322305 | 10257 | 29241917 |
Foetal growth restriction | 23.51 | 11.48 | 6 | 322347 | 3760 | 29248414 |
Balance disorder | 23.23 | 11.48 | 537 | 321816 | 35633 | 29216541 |
Colitis | 23.17 | 11.48 | 223 | 322130 | 31025 | 29221149 |
Cardiac aneurysm | 23.03 | 11.48 | 36 | 322317 | 786 | 29251388 |
Hyperammonaemia | 22.81 | 11.48 | 17 | 322336 | 5646 | 29246528 |
Candida infection | 22.78 | 11.48 | 87 | 322266 | 15138 | 29237036 |
Product odour abnormal | 22.77 | 11.48 | 32 | 322321 | 633 | 29251541 |
Sedation | 22.61 | 11.48 | 105 | 322248 | 17300 | 29234874 |
Dystonia | 22.60 | 11.48 | 45 | 322308 | 9704 | 29242470 |
Appendicitis | 22.60 | 11.48 | 38 | 322315 | 8741 | 29243433 |
Muscle discomfort | 22.49 | 11.48 | 12 | 322341 | 54 | 29252120 |
Drug level increased | 22.30 | 11.48 | 117 | 322236 | 18670 | 29233504 |
Nephropathy toxic | 22.17 | 11.48 | 53 | 322300 | 10703 | 29241471 |
Abnormal weight gain | 21.72 | 11.48 | 37 | 322316 | 870 | 29251304 |
Oropharyngeal pain | 21.71 | 11.48 | 209 | 322144 | 29076 | 29223098 |
Peripheral vascular disorder | 21.68 | 11.48 | 103 | 322250 | 4464 | 29247710 |
Diabetes mellitus | 21.60 | 11.48 | 578 | 321775 | 39253 | 29212921 |
Acquired claw toe | 21.46 | 11.48 | 9 | 322344 | 20 | 29252154 |
Ventricular septal defect | 21.32 | 11.48 | 6 | 322347 | 3523 | 29248651 |
Pelvic mass | 21.26 | 11.48 | 18 | 322335 | 194 | 29251980 |
Miosis | 21.24 | 11.48 | 34 | 322319 | 7975 | 29244199 |
Sinusitis | 21.11 | 11.48 | 256 | 322097 | 34094 | 29218080 |
Apparent death | 21.09 | 11.48 | 6 | 322347 | 3498 | 29248676 |
Ventricular dyskinesia | 21.04 | 11.48 | 18 | 322335 | 197 | 29251977 |
Altered state of consciousness | 20.83 | 11.48 | 129 | 322224 | 19760 | 29232414 |
Cardiotoxicity | 20.76 | 11.48 | 13 | 322340 | 4731 | 29247443 |
Klebsiella infection | 20.64 | 11.48 | 30 | 322323 | 7319 | 29244855 |
Accidental exposure to product | 20.60 | 11.48 | 55 | 322298 | 10698 | 29241476 |
Arterial stenosis | 20.55 | 11.48 | 41 | 322312 | 1092 | 29251082 |
Device related infection | 20.51 | 11.48 | 94 | 322259 | 15542 | 29236632 |
Chest discomfort | 20.47 | 11.48 | 651 | 321702 | 45332 | 29206842 |
Arterial occlusive disease | 20.36 | 11.48 | 91 | 322262 | 3843 | 29248331 |
Musculoskeletal pain | 20.21 | 11.48 | 435 | 321918 | 28518 | 29223656 |
Pulmonary vascular disorder | 20.11 | 11.48 | 28 | 322325 | 549 | 29251625 |
Idiopathic pulmonary fibrosis | 20.09 | 11.48 | 78 | 322275 | 3090 | 29249084 |
Paradoxical drug reaction | 19.98 | 11.48 | 3 | 322350 | 2738 | 29249436 |
Obstructive pancreatitis | 19.89 | 11.48 | 24 | 322329 | 406 | 29251768 |
Lymph node calcification | 19.88 | 11.48 | 15 | 322338 | 135 | 29252039 |
Pneumatosis intestinalis | 19.88 | 11.48 | 5 | 322348 | 3164 | 29249010 |
Hypertransaminasaemia | 19.87 | 11.48 | 85 | 322268 | 3521 | 29248653 |
Ileus | 19.84 | 11.48 | 85 | 322268 | 14317 | 29237857 |
Shock | 19.83 | 11.48 | 144 | 322209 | 21260 | 29230914 |
Hypercholesterolaemia | 19.77 | 11.48 | 141 | 322212 | 7097 | 29245077 |
Potassium wasting nephropathy | 19.74 | 11.48 | 13 | 322340 | 92 | 29252082 |
Myoglobin blood increased | 19.68 | 11.48 | 57 | 322296 | 1938 | 29250236 |
Pulmonary haemorrhage | 19.65 | 11.48 | 45 | 322308 | 9225 | 29242949 |
Quadriparesis | 19.63 | 11.48 | 42 | 322311 | 1177 | 29250997 |
Radiculitis brachial | 19.63 | 11.48 | 8 | 322345 | 16 | 29252158 |
Oxygen saturation decreased | 19.61 | 11.48 | 358 | 321995 | 44579 | 29207595 |
Blood immunoglobulin E increased | 19.56 | 11.48 | 56 | 322297 | 1891 | 29250283 |
Essential hypertension | 19.48 | 11.48 | 65 | 322288 | 2388 | 29249786 |
Memory impairment | 19.42 | 11.48 | 528 | 321825 | 35942 | 29216232 |
Pneumonia cytomegaloviral | 19.40 | 11.48 | 3 | 322350 | 2679 | 29249495 |
Fungal infection | 19.33 | 11.48 | 80 | 322273 | 13605 | 29238569 |
Cerebral infarction | 19.29 | 11.48 | 377 | 321976 | 24298 | 29227876 |
Muscle strain | 19.25 | 11.48 | 83 | 322270 | 3450 | 29248724 |
Atrial enlargement | 19.24 | 11.48 | 21 | 322332 | 317 | 29251857 |
Penile haemorrhage | 19.12 | 11.48 | 28 | 322325 | 576 | 29251598 |
Nicotine dependence | 19.05 | 11.48 | 25 | 322328 | 462 | 29251712 |
Shock haemorrhagic | 18.98 | 11.48 | 173 | 322180 | 9378 | 29242796 |
Pneumonia fungal | 18.91 | 11.48 | 21 | 322332 | 5756 | 29246418 |
Hepatitis acute | 18.90 | 11.48 | 128 | 322225 | 6334 | 29245840 |
Nocardiosis | 18.86 | 11.48 | 6 | 322347 | 3254 | 29248920 |
Aldolase increased | 18.83 | 11.48 | 11 | 322342 | 61 | 29252113 |
Brain oedema | 18.82 | 11.48 | 69 | 322284 | 12151 | 29240023 |
Cardiac valve disease | 18.79 | 11.48 | 71 | 322282 | 2777 | 29249397 |
Abdominal pain | 18.74 | 11.48 | 1247 | 321106 | 134110 | 29118064 |
Dermatitis atopic | 18.70 | 11.48 | 60 | 322293 | 2159 | 29250015 |
Iliac artery stenosis | 18.69 | 11.48 | 11 | 322342 | 62 | 29252112 |
Dyspnoea at rest | 18.68 | 11.48 | 77 | 322276 | 3137 | 29249037 |
Catatonia | 18.53 | 11.48 | 13 | 322340 | 4455 | 29247719 |
Somnolence | 18.49 | 11.48 | 836 | 321517 | 93119 | 29159055 |
Disease recurrence | 18.39 | 11.48 | 100 | 322253 | 15814 | 29236360 |
Ageusia | 18.33 | 11.48 | 163 | 322190 | 8775 | 29243399 |
C-reactive protein increased | 18.27 | 11.48 | 356 | 321997 | 43907 | 29208267 |
Herbal interaction | 18.21 | 11.48 | 20 | 322333 | 304 | 29251870 |
Enthesopathy | 18.20 | 11.48 | 9 | 322344 | 3734 | 29248440 |
Penis injury | 18.17 | 11.48 | 18 | 322335 | 241 | 29251933 |
Pruritus | 18.13 | 11.48 | 1494 | 320859 | 115355 | 29136819 |
Venoocclusive disease | 18.01 | 11.48 | 3 | 322350 | 2536 | 29249638 |
Hypocalcaemia | 17.98 | 11.48 | 321 | 322032 | 20344 | 29231830 |
Hepatitis B | 17.97 | 11.48 | 20 | 322333 | 5477 | 29246697 |
Lipids abnormal | 17.97 | 11.48 | 19 | 322334 | 276 | 29251898 |
Electrocardiogram abnormal | 17.94 | 11.48 | 139 | 322214 | 7183 | 29244991 |
Osteonecrosis of jaw | 17.86 | 11.48 | 106 | 322247 | 16404 | 29235770 |
Post micturition dribble | 17.85 | 11.48 | 7 | 322346 | 12 | 29252162 |
Clostridium difficile infection | 17.80 | 11.48 | 103 | 322250 | 16038 | 29236136 |
Transient global amnesia | 17.76 | 11.48 | 20 | 322333 | 313 | 29251861 |
Hyperbilirubinaemia | 17.72 | 11.48 | 93 | 322260 | 14841 | 29237333 |
Thrombotic microangiopathy | 17.71 | 11.48 | 43 | 322310 | 8638 | 29243536 |
Gastrointestinal angiodysplasia | 17.68 | 11.48 | 26 | 322327 | 537 | 29251637 |
Pericardial haemorrhage | 17.65 | 11.48 | 71 | 322282 | 2860 | 29249314 |
Withdrawal syndrome | 17.64 | 11.48 | 61 | 322292 | 10931 | 29241243 |
Neutropenic sepsis | 17.55 | 11.48 | 67 | 322286 | 11660 | 29240514 |
Hepatic failure | 17.46 | 11.48 | 240 | 322113 | 31272 | 29220902 |
Epicondylitis | 17.32 | 11.48 | 21 | 322332 | 357 | 29251817 |
Lymphadenopathy | 17.23 | 11.48 | 182 | 322171 | 24867 | 29227307 |
Vascular graft | 17.21 | 11.48 | 43 | 322310 | 1337 | 29250837 |
Aplastic anaemia | 17.12 | 11.48 | 35 | 322318 | 7475 | 29244699 |
Left atrial enlargement | 17.09 | 11.48 | 30 | 322323 | 723 | 29251451 |
Occupational problem environmental | 17.09 | 11.48 | 6 | 322347 | 6 | 29252168 |
Avoidant personality disorder | 17.09 | 11.48 | 6 | 322347 | 6 | 29252168 |
Product administered to patient of inappropriate age | 17.02 | 11.48 | 4 | 322349 | 2651 | 29249523 |
Cytomegalovirus test positive | 16.99 | 11.48 | 8 | 322345 | 3415 | 29248759 |
Skin toxicity | 16.97 | 11.48 | 10 | 322343 | 3761 | 29248413 |
Palmar-plantar erythrodysaesthesia syndrome | 16.91 | 11.48 | 93 | 322260 | 14666 | 29237508 |
Herpes simplex | 16.88 | 11.48 | 17 | 322336 | 4873 | 29247301 |
Neuromyopathy | 16.87 | 11.48 | 33 | 322320 | 866 | 29251308 |
Therapeutic product effect decreased | 16.79 | 11.48 | 223 | 322130 | 29228 | 29222946 |
Neutropenic colitis | 16.77 | 11.48 | 3 | 322350 | 2408 | 29249766 |
Hypogammaglobulinaemia | 16.70 | 11.48 | 24 | 322329 | 5883 | 29246291 |
Dyskinesia | 16.70 | 11.48 | 139 | 322214 | 19922 | 29232252 |
Fibrous histiocytoma | 16.65 | 11.48 | 12 | 322341 | 100 | 29252074 |
Blood triglycerides decreased | 16.63 | 11.48 | 10 | 322343 | 59 | 29252115 |
Epilepsy | 16.60 | 11.48 | 125 | 322228 | 18307 | 29233867 |
Vitreous detachment | 16.58 | 11.48 | 30 | 322323 | 741 | 29251433 |
Weight decreased | 16.56 | 11.48 | 1883 | 320470 | 149022 | 29103152 |
Pulmonary valve incompetence | 16.55 | 11.48 | 29 | 322324 | 698 | 29251476 |
Hepatic cytolysis | 16.49 | 11.48 | 151 | 322202 | 8196 | 29243978 |
Cytomegalovirus infection reactivation | 16.49 | 11.48 | 8 | 322345 | 3356 | 29248818 |
Diffuse large B-cell lymphoma recurrent | 16.48 | 11.48 | 4 | 322349 | 2593 | 29249581 |
Autoimmune disorder | 16.48 | 11.48 | 45 | 322308 | 1478 | 29250696 |
Clonus | 16.45 | 11.48 | 3 | 322350 | 2375 | 29249799 |
Myasthenia gravis | 16.39 | 11.48 | 73 | 322280 | 3078 | 29249096 |
Left atrial dilatation | 16.34 | 11.48 | 48 | 322305 | 1645 | 29250529 |
Bacterial infection | 16.30 | 11.48 | 79 | 322274 | 12869 | 29239305 |
Systemic candida | 16.29 | 11.48 | 5 | 322348 | 2775 | 29249399 |
Pollakiuria | 16.25 | 11.48 | 267 | 322086 | 16649 | 29235525 |
Cholestasis | 16.21 | 11.48 | 352 | 322001 | 23110 | 29229064 |
Therapy non-responder | 16.21 | 11.48 | 238 | 322115 | 30673 | 29221501 |
Peripheral paralysis | 16.10 | 11.48 | 8 | 322345 | 30 | 29252144 |
Flatulence | 16.09 | 11.48 | 277 | 322076 | 17432 | 29234742 |
Drug abuser | 16.05 | 11.48 | 11 | 322342 | 3816 | 29248358 |
Product contamination physical | 16.00 | 11.48 | 7 | 322346 | 18 | 29252156 |
Suicidal ideation | 15.96 | 11.48 | 274 | 322079 | 34442 | 29217732 |
Dyspnoea paroxysmal nocturnal | 15.90 | 11.48 | 42 | 322311 | 1352 | 29250822 |
Anticoagulation drug level increased | 15.78 | 11.48 | 23 | 322330 | 471 | 29251703 |
Aortic aneurysm | 15.75 | 11.48 | 119 | 322234 | 6101 | 29246073 |
Mastitis | 15.75 | 11.48 | 14 | 322339 | 162 | 29252012 |
Psychomotor hyperactivity | 15.74 | 11.48 | 42 | 322311 | 8171 | 29244003 |
Staphylococcal infection | 15.73 | 11.48 | 224 | 322129 | 29016 | 29223158 |
Haemorrhage intracranial | 15.67 | 11.48 | 234 | 322119 | 14308 | 29237866 |
Aortic valve replacement | 15.58 | 11.48 | 28 | 322325 | 688 | 29251486 |
Gout | 15.54 | 11.48 | 265 | 322088 | 16646 | 29235528 |
Atrial flutter | 15.53 | 11.48 | 225 | 322128 | 13669 | 29238505 |
Lip swelling | 15.51 | 11.48 | 205 | 322148 | 12205 | 29239969 |
Urine flow decreased | 15.49 | 11.48 | 36 | 322317 | 1068 | 29251106 |
Loss of personal independence in daily activities | 15.47 | 11.48 | 190 | 322163 | 25250 | 29226924 |
Haematoma muscle | 15.44 | 11.48 | 33 | 322320 | 924 | 29251250 |
Vertigo | 15.43 | 11.48 | 329 | 322024 | 21532 | 29230642 |
Bilirubin conjugated abnormal | 15.32 | 11.48 | 11 | 322342 | 91 | 29252083 |
Herpes zoster | 15.21 | 11.48 | 233 | 322120 | 29819 | 29222355 |
Anal abscess | 15.18 | 11.48 | 21 | 322332 | 5230 | 29246944 |
Synovitis | 15.17 | 11.48 | 64 | 322289 | 10826 | 29241348 |
Blood creatine increased | 15.16 | 11.48 | 89 | 322264 | 4189 | 29247985 |
Thrombocytopenic purpura | 15.15 | 11.48 | 34 | 322319 | 985 | 29251189 |
Autoimmune myocarditis | 15.15 | 11.48 | 14 | 322339 | 171 | 29252003 |
Mydriasis | 15.06 | 11.48 | 27 | 322326 | 6058 | 29246116 |
Alcohol abuse | 15.03 | 11.48 | 15 | 322338 | 4318 | 29247856 |
Escherichia infection | 15.02 | 11.48 | 32 | 322321 | 6732 | 29245442 |
Hepatojugular reflux | 14.90 | 11.48 | 22 | 322331 | 456 | 29251718 |
Right ventricular enlargement | 14.89 | 11.48 | 14 | 322339 | 175 | 29251999 |
Wound haematoma | 14.85 | 11.48 | 9 | 322344 | 54 | 29252120 |
Hypercalcaemia | 14.84 | 11.48 | 80 | 322273 | 12679 | 29239495 |
Central obesity | 14.83 | 11.48 | 22 | 322331 | 458 | 29251716 |
Peripheral ischaemia | 14.74 | 11.48 | 101 | 322252 | 5018 | 29247156 |
Blood pressure fluctuation | 14.74 | 11.48 | 142 | 322211 | 19752 | 29232422 |
Pneumonia aspiration | 14.70 | 11.48 | 297 | 322056 | 36440 | 29215734 |
Pneumonitis | 14.68 | 11.48 | 216 | 322137 | 27828 | 29224346 |
Scrotal pain | 14.67 | 11.48 | 29 | 322324 | 767 | 29251407 |
Dysmorphism | 14.66 | 11.48 | 7 | 322346 | 2964 | 29249210 |
Oscillopsia | 14.66 | 11.48 | 8 | 322345 | 38 | 29252136 |
Eructation | 14.63 | 11.48 | 84 | 322269 | 3922 | 29248252 |
Peripheral artery stenosis | 14.59 | 11.48 | 30 | 322323 | 817 | 29251357 |
Haemorrhagic transformation stroke | 14.54 | 11.48 | 39 | 322314 | 1267 | 29250907 |
Peripheral arterial occlusive disease | 14.52 | 11.48 | 100 | 322253 | 4976 | 29247198 |
Hyponatraemic syndrome | 14.52 | 11.48 | 14 | 322339 | 181 | 29251993 |
Osteonecrosis | 14.52 | 11.48 | 87 | 322266 | 13432 | 29238742 |
Heart valve incompetence | 14.50 | 11.48 | 37 | 322316 | 1166 | 29251008 |
Therapeutic response decreased | 14.49 | 11.48 | 186 | 322167 | 24525 | 29227649 |
Toe amputation | 14.44 | 11.48 | 54 | 322299 | 2101 | 29250073 |
Cardiomyopathy | 14.43 | 11.48 | 234 | 322119 | 14553 | 29237621 |
Orthopnoea | 14.35 | 11.48 | 92 | 322261 | 4468 | 29247706 |
Deep vein thrombosis | 14.26 | 11.48 | 497 | 321856 | 56902 | 29195272 |
Hepatic vein dilatation | 14.23 | 11.48 | 15 | 322338 | 217 | 29251957 |
Angiocardiogram | 14.22 | 11.48 | 14 | 322339 | 186 | 29251988 |
Lipodystrophy acquired | 14.22 | 11.48 | 8 | 322345 | 3086 | 29249088 |
Lipids increased | 14.15 | 11.48 | 29 | 322324 | 788 | 29251386 |
Arterial repair | 14.12 | 11.48 | 4 | 322349 | 0 | 29252174 |
Cells in urine | 14.12 | 11.48 | 4 | 322349 | 0 | 29252174 |
Blood glucose decreased | 14.11 | 11.48 | 197 | 322156 | 11872 | 29240302 |
Hypernatraemia | 13.98 | 11.48 | 38 | 322315 | 7348 | 29244826 |
Lacunar stroke | 13.98 | 11.48 | 12 | 322341 | 132 | 29252042 |
Blood creatine phosphokinase abnormal | 13.93 | 11.48 | 14 | 322339 | 191 | 29251983 |
Impatience | 13.89 | 11.48 | 17 | 322336 | 292 | 29251882 |
Discoloured vomit | 13.89 | 11.48 | 21 | 322332 | 445 | 29251729 |
Adrenal insufficiency | 13.88 | 11.48 | 68 | 322285 | 11046 | 29241128 |
Cardiac stress test abnormal | 13.86 | 11.48 | 18 | 322335 | 329 | 29251845 |
AST/ALT ratio abnormal | 13.83 | 11.48 | 6 | 322347 | 15 | 29252159 |
Rhinovirus infection | 13.82 | 11.48 | 9 | 322344 | 3207 | 29248967 |
Musculoskeletal stiffness | 13.77 | 11.48 | 307 | 322046 | 37151 | 29215023 |
Rheumatoid arthritis | 13.76 | 11.48 | 257 | 322096 | 31895 | 29220279 |
Congenital diaphragmatic anomaly | 13.75 | 11.48 | 7 | 322346 | 28 | 29252146 |
Hypertension | 13.73 | 11.48 | 1462 | 320891 | 115152 | 29137022 |
Accidental overdose | 13.71 | 11.48 | 124 | 322229 | 17469 | 29234705 |
Microcytic anaemia | 13.70 | 11.48 | 51 | 322302 | 1980 | 29250194 |
Transplant failure | 13.69 | 11.48 | 7 | 322346 | 2849 | 29249325 |
Peripheral artery occlusion | 13.68 | 11.48 | 41 | 322312 | 1421 | 29250753 |
Staphylococcal sepsis | 13.67 | 11.48 | 50 | 322303 | 8812 | 29243362 |
Mouth swelling | 13.64 | 11.48 | 43 | 322310 | 1533 | 29250641 |
Urticaria chronic | 13.62 | 11.48 | 10 | 322343 | 86 | 29252088 |
Lipoprotein (a) increased | 13.60 | 11.48 | 8 | 322345 | 45 | 29252129 |
Sopor | 13.60 | 11.48 | 67 | 322286 | 10867 | 29241307 |
Nausea | 13.59 | 11.48 | 2866 | 319487 | 286389 | 28965785 |
Hemianaesthesia | 13.53 | 11.48 | 10 | 322343 | 87 | 29252087 |
Pseudohyponatraemia | 13.52 | 11.48 | 9 | 322344 | 65 | 29252109 |
Cardiovascular disorder | 13.51 | 11.48 | 153 | 322200 | 8782 | 29243392 |
Drug level decreased | 13.50 | 11.48 | 30 | 322323 | 6217 | 29245957 |
Ataxia | 13.47 | 11.48 | 77 | 322276 | 12026 | 29240148 |
Calculus urinary | 13.46 | 11.48 | 35 | 322318 | 1116 | 29251058 |
Blood electrolytes abnormal | 13.41 | 11.48 | 30 | 322323 | 867 | 29251307 |
Ventricular hypertrophy | 13.40 | 11.48 | 86 | 322267 | 4178 | 29247996 |
Drug screen positive | 13.36 | 11.48 | 13 | 322340 | 3788 | 29248386 |
Infective exacerbation of chronic obstructive airways disease | 13.35 | 11.48 | 44 | 322309 | 1606 | 29250568 |
Atrioventricular block second degree | 13.30 | 11.48 | 69 | 322284 | 3099 | 29249075 |
Encephalitis toxic | 13.24 | 11.48 | 16 | 322337 | 271 | 29251903 |
Generalised tonic-clonic seizure | 13.18 | 11.48 | 139 | 322214 | 19000 | 29233174 |
Non-cardiac chest pain | 13.18 | 11.48 | 81 | 322272 | 3876 | 29248298 |
Clostridium difficile colitis | 13.17 | 11.48 | 87 | 322266 | 13125 | 29239049 |
Brain stem haematoma | 13.11 | 11.48 | 11 | 322342 | 117 | 29252057 |
Liver palpable | 13.11 | 11.48 | 16 | 322337 | 274 | 29251900 |
Spinal stenosis | 13.11 | 11.48 | 87 | 322266 | 4276 | 29247898 |
Second primary malignancy | 13.07 | 11.48 | 34 | 322319 | 6671 | 29245503 |
Inclusion body myositis | 13.06 | 11.48 | 6 | 322347 | 18 | 29252156 |
Large intestine polyp | 12.98 | 11.48 | 118 | 322235 | 6391 | 29245783 |
Electrocardiogram ST-T change | 12.98 | 11.48 | 22 | 322331 | 515 | 29251659 |
Mitochondrial toxicity | 12.98 | 11.48 | 5 | 322348 | 2406 | 29249768 |
Splenomegaly | 12.96 | 11.48 | 88 | 322265 | 13191 | 29238983 |
Facial asymmetry | 12.89 | 11.48 | 16 | 322337 | 279 | 29251895 |
Implantable defibrillator insertion | 12.83 | 11.48 | 25 | 322328 | 654 | 29251520 |
Hepatosplenomegaly | 12.74 | 11.48 | 13 | 322340 | 3704 | 29248470 |
Chronic obstructive pulmonary disease | 12.71 | 11.48 | 557 | 321796 | 40398 | 29211776 |
Intraventricular haemorrhage | 12.69 | 11.48 | 64 | 322289 | 2842 | 29249332 |
Normal tension glaucoma | 12.60 | 11.48 | 6 | 322347 | 20 | 29252154 |
Peripheral swelling | 12.60 | 11.48 | 831 | 321522 | 62908 | 29189266 |
Carcinoid tumour of the gastrointestinal tract | 12.57 | 11.48 | 8 | 322345 | 53 | 29252121 |
Macroglossia | 12.55 | 11.48 | 18 | 322335 | 363 | 29251811 |
Gait disturbance | 12.54 | 11.48 | 945 | 321408 | 72404 | 29179770 |
Metastases to central nervous system | 12.54 | 11.48 | 38 | 322315 | 7093 | 29245081 |
Hepatic cirrhosis | 12.52 | 11.48 | 99 | 322254 | 14345 | 29237829 |
Abnormal loss of weight | 12.49 | 11.48 | 75 | 322278 | 3559 | 29248615 |
Nipple pain | 12.49 | 11.48 | 23 | 322330 | 576 | 29251598 |
Coronary artery surgery | 12.49 | 11.48 | 10 | 322343 | 99 | 29252075 |
Injection site pain | 12.48 | 11.48 | 264 | 322089 | 32182 | 29219992 |
BK virus infection | 12.47 | 11.48 | 20 | 322333 | 4687 | 29247487 |
Spur cell anaemia | 12.45 | 11.48 | 8 | 322345 | 54 | 29252120 |
Electrocardiogram ST segment depression | 12.42 | 11.48 | 52 | 322301 | 2133 | 29250041 |
Lymphoproliferative disorder | 12.40 | 11.48 | 6 | 322347 | 2521 | 29249653 |
Adenocarcinoma gastric | 12.34 | 11.48 | 33 | 322320 | 1070 | 29251104 |
Pleural effusion | 12.34 | 11.48 | 649 | 321704 | 71259 | 29180915 |
Conjunctival hyperaemia | 12.32 | 11.48 | 4 | 322349 | 2141 | 29250033 |
Hypoxia | 12.29 | 11.48 | 408 | 321945 | 46971 | 29205203 |
Smooth muscle antibody positive | 12.27 | 11.48 | 5 | 322348 | 10 | 29252164 |
Primary biliary cholangitis | 12.25 | 11.48 | 11 | 322342 | 129 | 29252045 |
Lacunar infarction | 12.25 | 11.48 | 62 | 322291 | 2757 | 29249417 |
Food interaction | 12.24 | 11.48 | 29 | 322324 | 871 | 29251303 |
Vascular graft occlusion | 12.23 | 11.48 | 22 | 322331 | 541 | 29251633 |
Angioedema | 12.22 | 11.48 | 444 | 321909 | 31471 | 29220703 |
Carotid endarterectomy | 12.21 | 11.48 | 8 | 322345 | 56 | 29252118 |
Peritonitis | 12.21 | 11.48 | 103 | 322250 | 14721 | 29237453 |
Tuberculosis | 12.19 | 11.48 | 39 | 322314 | 7157 | 29245017 |
Ventricular arrhythmia | 12.18 | 11.48 | 89 | 322264 | 4515 | 29247659 |
Hypoaesthesia eye | 12.18 | 11.48 | 6 | 322347 | 22 | 29252152 |
Portal hypertension | 12.17 | 11.48 | 12 | 322341 | 3474 | 29248700 |
International normalised ratio increased | 12.16 | 11.48 | 596 | 321757 | 43776 | 29208398 |
Gait inability | 12.16 | 11.48 | 274 | 322079 | 18101 | 29234073 |
Liver transplant | 12.15 | 11.48 | 5 | 322348 | 2311 | 29249863 |
Congestive cardiomyopathy | 12.13 | 11.48 | 118 | 322235 | 6512 | 29245662 |
Rheumatoid nodule | 12.11 | 11.48 | 4 | 322349 | 2118 | 29250056 |
Lipid metabolism disorder | 12.10 | 11.48 | 16 | 322337 | 298 | 29251876 |
Intestinal obstruction | 12.09 | 11.48 | 143 | 322210 | 19134 | 29233040 |
Oesophageal pain | 12.07 | 11.48 | 26 | 322327 | 732 | 29251442 |
Neurodermatitis | 12.05 | 11.48 | 14 | 322339 | 227 | 29251947 |
Small intestinal obstruction | 12.04 | 11.48 | 88 | 322265 | 12973 | 29239201 |
Abscess | 12.03 | 11.48 | 60 | 322293 | 9702 | 29242472 |
Delirium | 12.01 | 11.48 | 332 | 322021 | 39065 | 29213109 |
Speech disorder developmental | 11.98 | 11.48 | 3 | 322350 | 1904 | 29250270 |
Sinonasal obstruction | 11.98 | 11.48 | 6 | 322347 | 23 | 29252151 |
Subdural haematoma | 11.95 | 11.48 | 271 | 322082 | 17922 | 29234252 |
Streptococcal infection | 11.95 | 11.48 | 19 | 322334 | 4469 | 29247705 |
Erythema | 11.94 | 11.48 | 688 | 321665 | 74918 | 29177256 |
Injection site erythema | 11.93 | 11.48 | 96 | 322257 | 13860 | 29238314 |
Paraesthesia | 11.93 | 11.48 | 709 | 321644 | 53136 | 29199038 |
Chronic kidney disease | 11.91 | 11.48 | 498 | 321855 | 35918 | 29216256 |
Peripheral coldness | 11.91 | 11.48 | 112 | 322241 | 6124 | 29246050 |
Left ventricular dilatation | 11.86 | 11.48 | 24 | 322329 | 646 | 29251528 |
Glycosylated haemoglobin abnormal | 11.80 | 11.48 | 10 | 322343 | 108 | 29252066 |
Primary hypoparathyroidism | 11.79 | 11.48 | 6 | 322347 | 24 | 29252150 |
Ammonia increased | 11.78 | 11.48 | 16 | 322337 | 4015 | 29248159 |
Pyonephrosis | 11.77 | 11.48 | 8 | 322345 | 60 | 29252114 |
Skin discomfort | 11.77 | 11.48 | 8 | 322345 | 60 | 29252114 |
Pneumothorax | 11.77 | 11.48 | 113 | 322240 | 15729 | 29236445 |
Bundle branch block left | 11.74 | 11.48 | 98 | 322255 | 5179 | 29246995 |
Periodontitis | 11.74 | 11.48 | 45 | 322308 | 1772 | 29250402 |
Infarction | 11.72 | 11.48 | 55 | 322298 | 2371 | 29249803 |
Mitral valve calcification | 11.71 | 11.48 | 21 | 322332 | 515 | 29251659 |
Lower gastrointestinal haemorrhage | 11.69 | 11.48 | 139 | 322214 | 8074 | 29244100 |
Heart valve stenosis | 11.66 | 11.48 | 5 | 322348 | 12 | 29252162 |
Gynaecomastia | 11.66 | 11.48 | 139 | 322214 | 8078 | 29244096 |
Nightmare | 11.64 | 11.48 | 182 | 322171 | 11235 | 29240939 |
Decreased gait velocity | 11.60 | 11.48 | 11 | 322342 | 139 | 29252035 |
Atrioventricular block complete | 11.58 | 11.48 | 136 | 322217 | 7875 | 29244299 |
Upper respiratory tract infection | 11.58 | 11.48 | 219 | 322134 | 27130 | 29225044 |
Inflammation | 11.57 | 11.48 | 176 | 322177 | 22552 | 29229622 |
Human herpesvirus 6 infection | 11.57 | 11.48 | 3 | 322350 | 1860 | 29250314 |
Mean cell volume abnormal | 11.56 | 11.48 | 15 | 322338 | 274 | 29251900 |
Staphylococcal bacteraemia | 11.55 | 11.48 | 39 | 322314 | 7040 | 29245134 |
Urinary retention | 11.55 | 11.48 | 441 | 321912 | 31457 | 29220717 |
Euglycaemic diabetic ketoacidosis | 11.54 | 11.48 | 58 | 322295 | 2572 | 29249602 |
Autoimmune hepatitis | 11.54 | 11.48 | 73 | 322280 | 3529 | 29248645 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Immune-mediated myositis | 1856.40 | 10.35 | 737 | 541943 | 1941 | 63954111 |
Myalgia | 1623.96 | 10.35 | 3901 | 538779 | 154716 | 63801336 |
Rhabdomyolysis | 1510.83 | 10.35 | 2743 | 539937 | 88983 | 63867069 |
Drug ineffective | 816.58 | 10.35 | 3972 | 538708 | 836275 | 63119777 |
Blood creatine phosphokinase increased | 697.38 | 10.35 | 1530 | 541150 | 57028 | 63899024 |
Myocardial infarction | 690.48 | 10.35 | 2995 | 539685 | 162826 | 63793226 |
Myopathy | 688.27 | 10.35 | 796 | 541884 | 16884 | 63939168 |
Maternal exposure during pregnancy | 653.19 | 10.35 | 38 | 542642 | 95846 | 63860206 |
Acute kidney injury | 633.63 | 10.35 | 6160 | 536520 | 443080 | 63512972 |
Toxicity to various agents | 611.28 | 10.35 | 1345 | 541335 | 362168 | 63593884 |
Off label use | 611.21 | 10.35 | 2995 | 539685 | 629811 | 63326241 |
Cerebrovascular accident | 567.99 | 10.35 | 2479 | 540201 | 135104 | 63820948 |
Necrotising myositis | 553.98 | 10.35 | 227 | 542453 | 667 | 63955385 |
Completed suicide | 552.88 | 10.35 | 644 | 542036 | 223770 | 63732282 |
Drug abuse | 479.11 | 10.35 | 258 | 542422 | 132116 | 63823936 |
Coronary artery disease | 475.38 | 10.35 | 1348 | 541332 | 59085 | 63896967 |
Exposure during pregnancy | 470.26 | 10.35 | 52 | 542628 | 77623 | 63878429 |
Acute myocardial infarction | 445.89 | 10.35 | 1446 | 541234 | 68272 | 63887780 |
Hand deformity | 421.09 | 10.35 | 27 | 542653 | 62744 | 63893308 |
Treatment failure | 407.85 | 10.35 | 238 | 542442 | 116578 | 63839474 |
Synovitis | 400.23 | 10.35 | 166 | 542514 | 98924 | 63857128 |
Pemphigus | 384.81 | 10.35 | 34 | 542646 | 60667 | 63895385 |
Febrile neutropenia | 382.08 | 10.35 | 618 | 542062 | 187039 | 63769013 |
Infusion related reaction | 353.57 | 10.35 | 522 | 542158 | 163945 | 63792107 |
Muscular weakness | 332.54 | 10.35 | 2019 | 540661 | 125319 | 63830733 |
Drug hypersensitivity | 327.79 | 10.35 | 3248 | 539432 | 234567 | 63721485 |
Contraindicated product administered | 314.04 | 10.35 | 267 | 542413 | 107562 | 63848490 |
Systemic lupus erythematosus | 307.04 | 10.35 | 134 | 542546 | 77478 | 63878574 |
Glossodynia | 298.00 | 10.35 | 87 | 542593 | 64609 | 63891443 |
Therapeutic product effect decreased | 295.88 | 10.35 | 320 | 542360 | 115031 | 63841021 |
Angina pectoris | 280.96 | 10.35 | 927 | 541753 | 44154 | 63911898 |
Drug interaction | 280.68 | 10.35 | 4440 | 538240 | 357643 | 63598409 |
Pericarditis | 261.82 | 10.35 | 99 | 542581 | 62417 | 63893635 |
Rheumatoid factor positive | 257.21 | 10.35 | 8 | 542672 | 34930 | 63921122 |
Arthropathy | 250.23 | 10.35 | 394 | 542286 | 120573 | 63835479 |
Polymyositis | 246.33 | 10.35 | 195 | 542485 | 2515 | 63953537 |
Chest pain | 244.11 | 10.35 | 3046 | 539634 | 232934 | 63723118 |
Drug intolerance | 240.40 | 10.35 | 795 | 541885 | 187197 | 63768855 |
Neutropenia | 232.06 | 10.35 | 1131 | 541549 | 238493 | 63717559 |
Hypomagnesaemia | 219.14 | 10.35 | 753 | 541927 | 36623 | 63919429 |
Pyrexia | 215.43 | 10.35 | 3356 | 539324 | 555288 | 63400764 |
Hyperkalaemia | 212.61 | 10.35 | 1519 | 541161 | 99610 | 63856442 |
Rheumatoid arthritis | 211.95 | 10.35 | 692 | 541988 | 163602 | 63792450 |
Coronary artery stenosis | 206.39 | 10.35 | 353 | 542327 | 10895 | 63945157 |
Product use issue | 205.56 | 10.35 | 625 | 542055 | 151090 | 63804962 |
Stomatitis | 204.68 | 10.35 | 381 | 542299 | 109224 | 63846828 |
Joint swelling | 201.96 | 10.35 | 1028 | 541652 | 214354 | 63741698 |
Transient ischaemic attack | 196.69 | 10.35 | 815 | 541865 | 43367 | 63912685 |
Angina unstable | 195.33 | 10.35 | 414 | 542266 | 15053 | 63940999 |
Duodenal ulcer perforation | 193.19 | 10.35 | 30 | 542650 | 34595 | 63921457 |
Atrial fibrillation | 192.79 | 10.35 | 2245 | 540435 | 168844 | 63787208 |
Coronary artery occlusion | 183.80 | 10.35 | 379 | 542301 | 13512 | 63942540 |
Alopecia | 183.28 | 10.35 | 744 | 541936 | 164946 | 63791106 |
Ischaemic stroke | 182.65 | 10.35 | 599 | 542081 | 28436 | 63927616 |
Sinusitis | 175.76 | 10.35 | 633 | 542047 | 145295 | 63810757 |
Muscle spasms | 175.46 | 10.35 | 1887 | 540793 | 139136 | 63816916 |
Syncope | 174.72 | 10.35 | 2062 | 540618 | 155573 | 63800479 |
Infection | 174.10 | 10.35 | 881 | 541799 | 183999 | 63772053 |
Helicobacter infection | 172.29 | 10.35 | 54 | 542626 | 38308 | 63917744 |
Acute coronary syndrome | 170.98 | 10.35 | 450 | 542230 | 18860 | 63937192 |
Wound | 170.90 | 10.35 | 236 | 542444 | 76241 | 63879811 |
Hypoglycaemia | 166.20 | 10.35 | 1310 | 541370 | 88582 | 63867470 |
Lactic acidosis | 164.84 | 10.35 | 981 | 541699 | 60429 | 63895623 |
Hypersensitivity | 160.00 | 10.35 | 982 | 541698 | 195470 | 63760582 |
Product use in unapproved indication | 155.48 | 10.35 | 861 | 541819 | 175757 | 63780295 |
Dizziness | 154.52 | 10.35 | 4723 | 537957 | 425440 | 63530612 |
Fall | 153.05 | 10.35 | 4589 | 538091 | 412237 | 63543815 |
Diabetic ketoacidosis | 150.93 | 10.35 | 573 | 542107 | 29272 | 63926780 |
Blood glucose increased | 148.48 | 10.35 | 1367 | 541313 | 96706 | 63859346 |
Sleep disorder due to general medical condition, insomnia type | 148.31 | 10.35 | 22 | 542658 | 26248 | 63929804 |
Pain | 147.09 | 10.35 | 3541 | 539139 | 549970 | 63406082 |
Asthenia | 143.27 | 10.35 | 4660 | 538020 | 423384 | 63532668 |
Bradycardia | 142.93 | 10.35 | 1573 | 541107 | 116646 | 63839406 |
Hypertensive emergency | 141.99 | 10.35 | 132 | 542548 | 2144 | 63953908 |
Drug resistance | 141.37 | 10.35 | 59 | 542621 | 35043 | 63921009 |
Gastrointestinal haemorrhage | 139.26 | 10.35 | 1714 | 540966 | 130598 | 63825454 |
Rectal haemorrhage | 138.38 | 10.35 | 943 | 541737 | 60874 | 63895178 |
Melaena | 136.46 | 10.35 | 844 | 541836 | 52704 | 63903348 |
Swelling | 134.04 | 10.35 | 794 | 541886 | 159424 | 63796628 |
Myositis | 133.31 | 10.35 | 370 | 542310 | 16007 | 63940045 |
Discomfort | 130.06 | 10.35 | 306 | 542374 | 80572 | 63875480 |
Cytomegalovirus infection | 129.47 | 10.35 | 76 | 542604 | 37123 | 63918929 |
Low density lipoprotein increased | 129.17 | 10.35 | 233 | 542447 | 7507 | 63948545 |
Folliculitis | 128.67 | 10.35 | 46 | 542634 | 30031 | 63926021 |
Intentional overdose | 126.50 | 10.35 | 364 | 542316 | 89580 | 63866472 |
Pregnancy | 126.17 | 10.35 | 14 | 542666 | 20851 | 63935201 |
Cardiac failure congestive | 125.31 | 10.35 | 1663 | 541017 | 128917 | 63827135 |
Irritable bowel syndrome | 124.97 | 10.35 | 80 | 542600 | 37289 | 63918763 |
Cardiac failure | 122.98 | 10.35 | 1676 | 541004 | 130697 | 63825355 |
Device expulsion | 120.95 | 10.35 | 17 | 542663 | 21119 | 63934933 |
Cholestasis | 119.24 | 10.35 | 715 | 541965 | 44157 | 63911895 |
Mucosal inflammation | 119.07 | 10.35 | 215 | 542465 | 62369 | 63893683 |
Myocardial ischaemia | 118.89 | 10.35 | 448 | 542232 | 22803 | 63933249 |
Autoimmune myositis | 118.14 | 10.35 | 48 | 542632 | 137 | 63955915 |
Malignant neoplasm progression | 117.86 | 10.35 | 518 | 542162 | 112353 | 63843699 |
Mitral valve incompetence | 117.53 | 10.35 | 476 | 542204 | 25062 | 63930990 |
Impaired healing | 115.73 | 10.35 | 207 | 542473 | 60266 | 63895786 |
Labelled drug-drug interaction medication error | 115.23 | 10.35 | 428 | 542252 | 21634 | 63934418 |
Dyspnoea | 115.12 | 10.35 | 7257 | 535423 | 711417 | 63244635 |
Intentional self-injury | 115.07 | 10.35 | 50 | 542630 | 28994 | 63927058 |
Cerebral haemorrhage | 114.72 | 10.35 | 780 | 541900 | 50310 | 63905742 |
Product monitoring error | 113.29 | 10.35 | 181 | 542499 | 5273 | 63950779 |
Liver function test abnormal | 111.61 | 10.35 | 869 | 541811 | 58532 | 63897520 |
Glycosylated haemoglobin increased | 111.28 | 10.35 | 342 | 542338 | 15677 | 63940375 |
Haematuria | 108.33 | 10.35 | 875 | 541805 | 59596 | 63896456 |
Bone marrow failure | 107.10 | 10.35 | 148 | 542532 | 47804 | 63908248 |
Condition aggravated | 107.03 | 10.35 | 2353 | 540327 | 370073 | 63585979 |
Respiratory depression | 105.27 | 10.35 | 33 | 542647 | 23410 | 63932642 |
Premature delivery | 103.95 | 10.35 | 16 | 542664 | 18573 | 63937479 |
Hepatitis cholestatic | 103.30 | 10.35 | 279 | 542401 | 11876 | 63944176 |
Hepatocellular injury | 102.99 | 10.35 | 693 | 541987 | 44542 | 63911510 |
Abdominal discomfort | 102.57 | 10.35 | 1009 | 541671 | 181313 | 63774739 |
Haematochezia | 101.37 | 10.35 | 927 | 541753 | 65446 | 63890606 |
Intentional product use issue | 101.18 | 10.35 | 435 | 542245 | 94929 | 63861123 |
Abortion spontaneous | 98.48 | 10.35 | 44 | 542636 | 25099 | 63930953 |
Pancytopenia | 97.97 | 10.35 | 754 | 541926 | 142555 | 63813497 |
Upper gastrointestinal haemorrhage | 96.66 | 10.35 | 566 | 542114 | 34654 | 63921398 |
Pancreatitis acute | 96.65 | 10.35 | 655 | 542025 | 42200 | 63913852 |
Muscle necrosis | 96.42 | 10.35 | 81 | 542599 | 1142 | 63954910 |
Injection site erythema | 96.31 | 10.35 | 291 | 542389 | 70509 | 63885543 |
Blood triglycerides increased | 96.04 | 10.35 | 363 | 542317 | 18503 | 63937549 |
Chromaturia | 95.88 | 10.35 | 411 | 542269 | 22200 | 63933852 |
Neutrophil count decreased | 95.48 | 10.35 | 331 | 542349 | 76865 | 63879187 |
Leukopenia | 94.92 | 10.35 | 483 | 542197 | 100759 | 63855293 |
Hyponatraemia | 94.62 | 10.35 | 1764 | 540916 | 146575 | 63809477 |
Muscle rupture | 93.84 | 10.35 | 125 | 542555 | 3075 | 63952977 |
Cardiac disorder | 93.74 | 10.35 | 796 | 541884 | 55020 | 63901032 |
Musculoskeletal stiffness | 92.54 | 10.35 | 631 | 542049 | 122575 | 63833477 |
Injection site pain | 91.62 | 10.35 | 555 | 542125 | 110853 | 63845199 |
Myelosuppression | 91.32 | 10.35 | 43 | 542637 | 23787 | 63932265 |
White blood cell count decreased | 89.82 | 10.35 | 871 | 541809 | 156966 | 63799086 |
Erectile dysfunction | 89.03 | 10.35 | 271 | 542409 | 12356 | 63943696 |
Respiratory arrest | 88.80 | 10.35 | 196 | 542484 | 52789 | 63903263 |
Nasopharyngitis | 88.27 | 10.35 | 1141 | 541539 | 194932 | 63761120 |
Rash | 86.97 | 10.35 | 3071 | 539609 | 455478 | 63500574 |
Graft versus host disease | 86.82 | 10.35 | 8 | 542672 | 13805 | 63942247 |
Ill-defined disorder | 86.82 | 10.35 | 148 | 542532 | 43904 | 63912148 |
Ischaemic cardiomyopathy | 84.00 | 10.35 | 181 | 542499 | 6657 | 63949395 |
Myocardial necrosis marker increased | 83.85 | 10.35 | 110 | 542570 | 2665 | 63953387 |
Renal failure | 83.44 | 10.35 | 2060 | 540620 | 179628 | 63776424 |
Autoimmune hepatitis | 83.24 | 10.35 | 229 | 542451 | 9855 | 63946197 |
Myopathy toxic | 82.68 | 10.35 | 64 | 542616 | 797 | 63955255 |
Arteriosclerosis | 82.07 | 10.35 | 307 | 542373 | 15570 | 63940482 |
Caesarean section | 81.50 | 10.35 | 3 | 542677 | 11271 | 63944781 |
Neurotoxicity | 80.79 | 10.35 | 67 | 542613 | 27337 | 63928715 |
Neurologic neglect syndrome | 80.66 | 10.35 | 83 | 542597 | 1535 | 63954517 |
Vascular stent thrombosis | 80.21 | 10.35 | 119 | 542561 | 3245 | 63952807 |
High density lipoprotein decreased | 79.29 | 10.35 | 129 | 542551 | 3817 | 63952235 |
Oedema peripheral | 79.00 | 10.35 | 2323 | 540357 | 207994 | 63748058 |
Carotid artery thrombosis | 78.70 | 10.35 | 86 | 542594 | 1709 | 63954343 |
Red blood cell sedimentation rate abnormal | 76.79 | 10.35 | 21 | 542659 | 16285 | 63939767 |
Diabetes mellitus inadequate control | 75.84 | 10.35 | 368 | 542312 | 20953 | 63935099 |
Carotid artery stenosis | 75.40 | 10.35 | 190 | 542490 | 7751 | 63948301 |
C-reactive protein increased | 75.34 | 10.35 | 478 | 542202 | 94431 | 63861621 |
Poisoning | 74.31 | 10.35 | 46 | 542634 | 21833 | 63934219 |
Faeces discoloured | 74.22 | 10.35 | 419 | 542261 | 25310 | 63930742 |
Gastrointestinal disorder | 73.70 | 10.35 | 447 | 542233 | 89262 | 63866790 |
Suicide attempt | 73.43 | 10.35 | 327 | 542353 | 70680 | 63885372 |
Injection site reaction | 72.28 | 10.35 | 180 | 542500 | 46484 | 63909568 |
Tendon rupture | 72.13 | 10.35 | 227 | 542453 | 10540 | 63945512 |
Hepatitis acute | 71.81 | 10.35 | 262 | 542418 | 13127 | 63942925 |
Haematoma | 71.65 | 10.35 | 648 | 542032 | 45602 | 63910450 |
Drug-induced liver injury | 71.52 | 10.35 | 663 | 542017 | 46980 | 63909072 |
Therapeutic product effect incomplete | 71.39 | 10.35 | 543 | 542137 | 102939 | 63853113 |
Platelet count decreased | 71.10 | 10.35 | 988 | 541692 | 166723 | 63789329 |
Coma | 69.68 | 10.35 | 441 | 542239 | 87174 | 63868878 |
Mixed liver injury | 69.54 | 10.35 | 147 | 542533 | 5334 | 63950718 |
Product substitution issue | 69.17 | 10.35 | 316 | 542364 | 17545 | 63938507 |
Product prescribing error | 69.05 | 10.35 | 521 | 542159 | 34748 | 63921304 |
Anaemia | 68.88 | 10.35 | 3869 | 538811 | 374811 | 63581241 |
Blood loss anaemia | 67.19 | 10.35 | 263 | 542417 | 13629 | 63942423 |
Haemophagocytic lymphohistiocytosis | 67.13 | 10.35 | 32 | 542648 | 17577 | 63938475 |
Presyncope | 66.83 | 10.35 | 515 | 542165 | 34574 | 63921478 |
Cardiac failure chronic | 66.54 | 10.35 | 197 | 542483 | 8844 | 63947208 |
Bronchopulmonary aspergillosis | 66.40 | 10.35 | 39 | 542641 | 19046 | 63937006 |
Dyspnoea exertional | 66.19 | 10.35 | 928 | 541752 | 72802 | 63883250 |
Pneumocystis jirovecii pneumonia | 66.12 | 10.35 | 81 | 542599 | 27553 | 63928499 |
Inferior vena cava dilatation | 65.85 | 10.35 | 53 | 542627 | 701 | 63955351 |
C-reactive protein abnormal | 65.52 | 10.35 | 89 | 542591 | 28958 | 63927094 |
Vascular stent stenosis | 64.99 | 10.35 | 67 | 542613 | 1242 | 63954810 |
Muscle atrophy | 64.70 | 10.35 | 205 | 542475 | 9553 | 63946499 |
International normalised ratio increased | 63.81 | 10.35 | 978 | 541702 | 78189 | 63877863 |
Aspergillus infection | 63.62 | 10.35 | 29 | 542651 | 16350 | 63939702 |
Glomerular filtration rate decreased | 63.40 | 10.35 | 329 | 542351 | 19243 | 63936809 |
Pathogen resistance | 63.26 | 10.35 | 14 | 542666 | 12529 | 63943523 |
Chronic kidney disease | 62.05 | 10.35 | 753 | 541927 | 57166 | 63898886 |
Serotonin syndrome | 61.25 | 10.35 | 151 | 542529 | 39131 | 63916921 |
Renal impairment | 61.11 | 10.35 | 1528 | 541152 | 133489 | 63822563 |
Blood creatine phosphokinase MB increased | 60.04 | 10.35 | 91 | 542589 | 2530 | 63953522 |
Injection site swelling | 59.87 | 10.35 | 165 | 542515 | 41188 | 63914864 |
Swollen tongue | 59.49 | 10.35 | 500 | 542180 | 34454 | 63921598 |
Pemphigoid | 58.92 | 10.35 | 241 | 542439 | 12745 | 63943307 |
Haemorrhage intracranial | 58.68 | 10.35 | 373 | 542307 | 23511 | 63932541 |
Low density lipoprotein decreased | 58.15 | 10.35 | 58 | 542622 | 1032 | 63955020 |
Dermatomyositis | 58.11 | 10.35 | 93 | 542587 | 2713 | 63953339 |
Overdose | 57.40 | 10.35 | 970 | 541710 | 158596 | 63797456 |
Arteriosclerosis coronary artery | 57.38 | 10.35 | 271 | 542409 | 15258 | 63940794 |
Therapeutic response decreased | 57.23 | 10.35 | 235 | 542445 | 51953 | 63904099 |
Acute myeloid leukaemia | 57.17 | 10.35 | 89 | 542591 | 27374 | 63928678 |
Epstein-Barr virus infection | 57.11 | 10.35 | 17 | 542663 | 12471 | 63943581 |
Injection site pruritus | 56.97 | 10.35 | 148 | 542532 | 37678 | 63918374 |
Chronic obstructive pulmonary disease | 56.23 | 10.35 | 875 | 541805 | 70173 | 63885879 |
Atrioventricular block complete | 55.77 | 10.35 | 255 | 542425 | 14163 | 63941889 |
Muscle injury | 55.68 | 10.35 | 85 | 542595 | 26352 | 63929700 |
Atrioventricular block | 55.32 | 10.35 | 224 | 542456 | 11791 | 63944261 |
Hepatitis | 55.26 | 10.35 | 607 | 542073 | 44975 | 63911077 |
Ascites | 55.19 | 10.35 | 301 | 542379 | 61700 | 63894352 |
Venoocclusive liver disease | 55.14 | 10.35 | 9 | 542671 | 10006 | 63946046 |
Diabetes mellitus | 55.04 | 10.35 | 825 | 541855 | 65649 | 63890403 |
Rheumatoid nodule | 54.71 | 10.35 | 19 | 542661 | 12632 | 63943420 |
Blister | 54.37 | 10.35 | 428 | 542252 | 80539 | 63875513 |
Accidental exposure to product | 53.41 | 10.35 | 87 | 542593 | 26277 | 63929775 |
Hypocalcaemia | 53.40 | 10.35 | 562 | 542118 | 41191 | 63914861 |
Polymyalgia rheumatica | 53.37 | 10.35 | 99 | 542581 | 3260 | 63952792 |
Transplant rejection | 53.23 | 10.35 | 41 | 542639 | 17360 | 63938692 |
Amnesia | 53.22 | 10.35 | 631 | 542049 | 47638 | 63908414 |
Haematotoxicity | 53.02 | 10.35 | 21 | 542659 | 12875 | 63943177 |
Coronary artery restenosis | 52.99 | 10.35 | 60 | 542620 | 1242 | 63954810 |
Low density lipoprotein abnormal | 52.97 | 10.35 | 33 | 542647 | 281 | 63955771 |
Rheumatic fever | 51.96 | 10.35 | 8 | 542672 | 9286 | 63946766 |
Premature labour | 51.93 | 10.35 | 3 | 542677 | 7617 | 63948435 |
Immune reconstitution inflammatory syndrome | 51.78 | 10.35 | 20 | 542660 | 12450 | 63943602 |
Hip arthroplasty | 51.70 | 10.35 | 62 | 542618 | 21289 | 63934763 |
Jaundice | 51.66 | 10.35 | 630 | 542050 | 47882 | 63908170 |
Myoglobin blood increased | 51.44 | 10.35 | 87 | 542593 | 2660 | 63953392 |
Fibromyalgia | 50.66 | 10.35 | 144 | 542536 | 35587 | 63920465 |
Subdural haematoma | 50.26 | 10.35 | 406 | 542274 | 27648 | 63928404 |
Cerebral infarction | 49.96 | 10.35 | 547 | 542133 | 40497 | 63915555 |
Adenovirus infection | 49.01 | 10.35 | 3 | 542677 | 7252 | 63948800 |
Cytokine release syndrome | 48.84 | 10.35 | 62 | 542618 | 20767 | 63935285 |
Lymphocyte count decreased | 48.65 | 10.35 | 177 | 542503 | 40522 | 63915530 |
Intentional product misuse | 48.61 | 10.35 | 382 | 542298 | 71913 | 63884139 |
Cardio-respiratory arrest | 47.47 | 10.35 | 564 | 542116 | 97829 | 63858223 |
Migraine | 47.04 | 10.35 | 321 | 542359 | 62356 | 63893696 |
Hypotension | 47 | 10.35 | 3768 | 538912 | 377206 | 63578846 |
Cardiotoxicity | 46.96 | 10.35 | 14 | 542666 | 10260 | 63945792 |
Large intestine polyp | 46.73 | 10.35 | 198 | 542482 | 10639 | 63945413 |
Sedation | 46.53 | 10.35 | 185 | 542495 | 41277 | 63914775 |
Orthostatic hypotension | 46.36 | 10.35 | 599 | 542081 | 46139 | 63909913 |
Progressive multifocal leukoencephalopathy | 46.25 | 10.35 | 51 | 542629 | 18181 | 63937871 |
Thrombocytopenia | 46.01 | 10.35 | 1483 | 541197 | 222318 | 63733734 |
Knee arthroplasty | 45.96 | 10.35 | 99 | 542581 | 26900 | 63929152 |
Ocular myasthenia | 45.21 | 10.35 | 32 | 542648 | 344 | 63955708 |
Hypertransaminasaemia | 44.90 | 10.35 | 148 | 542532 | 7043 | 63949009 |
N-terminal prohormone brain natriuretic peptide increased | 44.63 | 10.35 | 95 | 542585 | 3464 | 63952588 |
Panniculitis | 44.60 | 10.35 | 10 | 542670 | 8869 | 63947183 |
Drug ineffective for unapproved indication | 44.49 | 10.35 | 125 | 542555 | 31008 | 63925044 |
Muscle disorder | 44.46 | 10.35 | 116 | 542564 | 4835 | 63951217 |
Cardiac failure acute | 44.42 | 10.35 | 262 | 542418 | 16082 | 63939970 |
Confusional state | 44.12 | 10.35 | 2651 | 540029 | 258493 | 63697559 |
Muscle enzyme increased | 43.90 | 10.35 | 31 | 542649 | 332 | 63955720 |
Ejection fraction decreased | 43.84 | 10.35 | 401 | 542279 | 28306 | 63927746 |
Hepatic enzyme increased | 43.82 | 10.35 | 799 | 541881 | 129144 | 63826908 |
Hemiparesis | 43.72 | 10.35 | 413 | 542267 | 29414 | 63926638 |
Troponin increased | 43.24 | 10.35 | 249 | 542431 | 15150 | 63940902 |
Coronary artery bypass | 43.07 | 10.35 | 127 | 542553 | 5688 | 63950364 |
Hyperlipidaemia | 43.07 | 10.35 | 336 | 542344 | 22640 | 63933412 |
Multiple-drug resistance | 43.00 | 10.35 | 3 | 542677 | 6499 | 63949553 |
Disease progression | 42.96 | 10.35 | 887 | 541793 | 140793 | 63815259 |
Angioedema | 42.49 | 10.35 | 744 | 541936 | 61077 | 63894975 |
Hemiplegia | 42.31 | 10.35 | 216 | 542464 | 12552 | 63943500 |
Nocturia | 42.10 | 10.35 | 196 | 542484 | 10969 | 63945083 |
Diabetic nephropathy | 41.89 | 10.35 | 78 | 542602 | 2576 | 63953476 |
Pneumonia | 41.85 | 10.35 | 4097 | 538583 | 555479 | 63400573 |
Post transplant lymphoproliferative disorder | 41.85 | 10.35 | 14 | 542666 | 9530 | 63946522 |
Hyperglycaemia | 41.64 | 10.35 | 733 | 541947 | 60235 | 63895817 |
Haemorrhagic stroke | 41.51 | 10.35 | 180 | 542500 | 9771 | 63946281 |
Device dislocation | 40.95 | 10.35 | 72 | 542608 | 21106 | 63934946 |
Psychotic disorder | 40.92 | 10.35 | 151 | 542529 | 34427 | 63921625 |
Enthesopathy | 40.78 | 10.35 | 15 | 542665 | 9623 | 63946429 |
Sedation complication | 40.74 | 10.35 | 18 | 542662 | 10336 | 63945716 |
Inflammation | 40.74 | 10.35 | 352 | 542328 | 64948 | 63891104 |
Myelodysplastic syndrome | 40.70 | 10.35 | 109 | 542571 | 27470 | 63928582 |
Computerised tomogram coronary artery abnormal | 40.59 | 10.35 | 24 | 542656 | 184 | 63955868 |
Arthralgia | 40.42 | 10.35 | 3188 | 539492 | 439072 | 63516980 |
Device issue | 40.27 | 10.35 | 81 | 542599 | 22567 | 63933485 |
Pallor | 40.15 | 10.35 | 501 | 542179 | 38280 | 63917772 |
Type V hyperlipidaemia | 40.12 | 10.35 | 44 | 542636 | 878 | 63955174 |
Adjustment disorder | 40.03 | 10.35 | 78 | 542602 | 2667 | 63953385 |
Posterior reversible encephalopathy syndrome | 40.01 | 10.35 | 83 | 542597 | 22863 | 63933189 |
Swollen joint count increased | 39.98 | 10.35 | 8 | 542672 | 7681 | 63948371 |
Euglycaemic diabetic ketoacidosis | 39.93 | 10.35 | 118 | 542562 | 5292 | 63950760 |
Tricuspid valve incompetence | 39.60 | 10.35 | 262 | 542418 | 16741 | 63939311 |
Unintentional medical device removal | 39.52 | 10.35 | 5 | 542675 | 6729 | 63949323 |
Lower respiratory tract infection | 39.49 | 10.35 | 559 | 542121 | 94055 | 63861997 |
Candida infection | 39.32 | 10.35 | 134 | 542546 | 31285 | 63924767 |
Electrocardiogram abnormal | 39.18 | 10.35 | 220 | 542460 | 13261 | 63942791 |
Disseminated intravascular coagulation | 39.12 | 10.35 | 140 | 542540 | 32208 | 63923844 |
Dysarthria | 39.08 | 10.35 | 710 | 541970 | 58696 | 63897356 |
Seizure | 38.97 | 10.35 | 1087 | 541593 | 165805 | 63790247 |
Weight decreased | 38.67 | 10.35 | 2847 | 539833 | 282892 | 63673160 |
Tumour lysis syndrome | 38.59 | 10.35 | 65 | 542615 | 19375 | 63936677 |
Cardiac murmur | 38.58 | 10.35 | 196 | 542484 | 11367 | 63944685 |
Bone erosion | 38.52 | 10.35 | 25 | 542655 | 11570 | 63944482 |
Exercise lack of | 38.52 | 10.35 | 31 | 542649 | 410 | 63955642 |
Pre-eclampsia | 38.14 | 10.35 | 4 | 542676 | 6227 | 63949825 |
Cholestatic liver injury | 38.09 | 10.35 | 91 | 542589 | 3588 | 63952464 |
Blood glucose decreased | 37.89 | 10.35 | 328 | 542352 | 22795 | 63933257 |
Loss of personal independence in daily activities | 37.82 | 10.35 | 408 | 542272 | 72046 | 63884006 |
Headache | 37.59 | 10.35 | 3891 | 538789 | 525576 | 63430476 |
Neoplasm progression | 37.49 | 10.35 | 197 | 542483 | 40767 | 63915285 |
Arterial stenosis | 37.43 | 10.35 | 52 | 542628 | 1333 | 63954719 |
Hepatic cytolysis | 37.40 | 10.35 | 224 | 542456 | 13825 | 63942227 |
Red blood cell sedimentation rate increased | 37.23 | 10.35 | 136 | 542544 | 31099 | 63924953 |
Personality disorder | 36.93 | 10.35 | 105 | 542575 | 4606 | 63951446 |
Drug use disorder | 36.76 | 10.35 | 4 | 542676 | 6050 | 63950002 |
Mydriasis | 36.51 | 10.35 | 45 | 542635 | 15267 | 63940785 |
Febrile bone marrow aplasia | 36.41 | 10.35 | 25 | 542655 | 11230 | 63944822 |
Hypovolaemic shock | 36.37 | 10.35 | 177 | 542503 | 10089 | 63945963 |
Bacteraemia | 36.31 | 10.35 | 111 | 542569 | 26800 | 63929252 |
Shock haemorrhagic | 36.29 | 10.35 | 254 | 542426 | 16537 | 63939515 |
Haematemesis | 36.11 | 10.35 | 576 | 542104 | 46423 | 63909629 |
Death | 35.95 | 10.35 | 3535 | 539145 | 479170 | 63476882 |
Ventricular hypokinesia | 35.90 | 10.35 | 145 | 542535 | 7624 | 63948428 |
Fungal infection | 35.84 | 10.35 | 157 | 542523 | 34094 | 63921958 |
Sepsis | 35.65 | 10.35 | 1579 | 541101 | 228762 | 63727290 |
Device related infection | 35.43 | 10.35 | 135 | 542545 | 30491 | 63925561 |
Gamma-glutamyltransferase increased | 35.22 | 10.35 | 589 | 542091 | 47921 | 63908131 |
Peripheral artery stenosis | 35.11 | 10.35 | 47 | 542633 | 1162 | 63954890 |
Uterine perforation | 34.95 | 10.35 | 4 | 542676 | 5816 | 63950236 |
Carotid artery occlusion | 34.94 | 10.35 | 93 | 542587 | 3924 | 63952128 |
Psoriatic arthropathy | 34.84 | 10.35 | 217 | 542463 | 43064 | 63912988 |
Paradoxical drug reaction | 34.84 | 10.35 | 5 | 542675 | 6115 | 63949937 |
Tenosynovitis | 34.80 | 10.35 | 29 | 542651 | 11804 | 63944248 |
Immunodeficiency | 34.78 | 10.35 | 51 | 542629 | 16073 | 63939979 |
Ventricular hypertrophy | 34.52 | 10.35 | 127 | 542553 | 6389 | 63949663 |
Urinary retention | 34.49 | 10.35 | 594 | 542086 | 48607 | 63907445 |
Left atrial enlargement | 34.48 | 10.35 | 43 | 542637 | 989 | 63955063 |
Herpes zoster | 34.43 | 10.35 | 464 | 542216 | 78723 | 63877329 |
Enterococcal infection | 33.85 | 10.35 | 40 | 542640 | 13826 | 63942226 |
Drug dependence | 33.48 | 10.35 | 155 | 542525 | 33157 | 63922895 |
Hepatitis toxic | 33.46 | 10.35 | 97 | 542583 | 4303 | 63951749 |
Muscle discomfort | 33.38 | 10.35 | 18 | 542662 | 113 | 63955939 |
Exercise tolerance decreased | 33.34 | 10.35 | 141 | 542539 | 7569 | 63948483 |
Eosinophilia | 33.26 | 10.35 | 477 | 542203 | 37599 | 63918453 |
Amyotrophic lateral sclerosis | 33.23 | 10.35 | 54 | 542626 | 1596 | 63954456 |
Idiopathic pulmonary fibrosis | 33.07 | 10.35 | 88 | 542592 | 3712 | 63952340 |
Blood cholesterol decreased | 32.79 | 10.35 | 51 | 542629 | 1451 | 63954601 |
Haemorrhagic transformation stroke | 32.57 | 10.35 | 66 | 542614 | 2323 | 63953729 |
Abortion induced | 32.48 | 10.35 | 7 | 542673 | 6381 | 63949671 |
Stent placement | 32.44 | 10.35 | 112 | 542568 | 5459 | 63950593 |
Flushing | 32.35 | 10.35 | 466 | 542214 | 78182 | 63877870 |
Peripheral vascular disorder | 32.35 | 10.35 | 134 | 542546 | 7127 | 63948925 |
Cerebral haematoma | 32.33 | 10.35 | 133 | 542547 | 7052 | 63949000 |
Multiple sclerosis relapse | 32.21 | 10.35 | 208 | 542472 | 40927 | 63915125 |
Lip swelling | 32.10 | 10.35 | 410 | 542270 | 31497 | 63924555 |
Adverse drug reaction | 32.09 | 10.35 | 237 | 542443 | 45227 | 63910825 |
Heart rate irregular | 31.84 | 10.35 | 362 | 542318 | 27051 | 63929001 |
Mouth swelling | 31.79 | 10.35 | 105 | 542575 | 5002 | 63951050 |
Pancreatitis | 31.38 | 10.35 | 689 | 541991 | 58918 | 63897134 |
Microcytic anaemia | 31.27 | 10.35 | 98 | 542582 | 4540 | 63951512 |
Aortic stenosis | 31.19 | 10.35 | 121 | 542559 | 6244 | 63949808 |
Erythema | 30.89 | 10.35 | 1273 | 541407 | 185797 | 63770255 |
Aortic aneurysm | 30.83 | 10.35 | 136 | 542544 | 7438 | 63948614 |
Hypertensive crisis | 30.50 | 10.35 | 260 | 542420 | 17988 | 63938064 |
Exposure via ingestion | 30.38 | 10.35 | 3 | 542677 | 4899 | 63951153 |
Atrial flutter | 30.25 | 10.35 | 272 | 542408 | 19108 | 63936944 |
Abnormal loss of weight | 30.21 | 10.35 | 133 | 542547 | 7267 | 63948785 |
Oropharyngeal pain | 30.09 | 10.35 | 546 | 542134 | 88321 | 63867731 |
Ventricular enlargement | 30.08 | 10.35 | 29 | 542651 | 494 | 63955558 |
Device adhesion issue | 30.08 | 10.35 | 4 | 542676 | 5182 | 63950870 |
Aplastic anaemia | 30.05 | 10.35 | 44 | 542636 | 13876 | 63942176 |
Subarachnoid haemorrhage | 29.93 | 10.35 | 261 | 542419 | 18177 | 63937875 |
Acute respiratory distress syndrome | 29.91 | 10.35 | 198 | 542482 | 38737 | 63917315 |
Dystonia | 29.82 | 10.35 | 72 | 542608 | 18793 | 63937259 |
Incorrect dosage administered | 29.76 | 10.35 | 61 | 542619 | 2165 | 63953887 |
Amenorrhoea | 29.73 | 10.35 | 9 | 542671 | 6530 | 63949522 |
Peripheral arterial occlusive disease | 29.62 | 10.35 | 127 | 542553 | 6860 | 63949192 |
Blood cholesterol abnormal | 29.59 | 10.35 | 68 | 542612 | 2613 | 63953439 |
Substance abuse | 29.58 | 10.35 | 21 | 542659 | 9271 | 63946781 |
Cystitis haemorrhagic | 29.51 | 10.35 | 15 | 542665 | 7941 | 63948111 |
Blood urea abnormal | 29.19 | 10.35 | 43 | 542637 | 1165 | 63954887 |
Gout | 29.18 | 10.35 | 292 | 542388 | 21121 | 63934931 |
Gynaecomastia | 29.18 | 10.35 | 114 | 542566 | 5902 | 63950150 |
Dehydration | 29.18 | 10.35 | 2159 | 540521 | 214604 | 63741448 |
Foetal death | 29.15 | 10.35 | 7 | 542673 | 5923 | 63950129 |
Aphasia | 29.08 | 10.35 | 495 | 542185 | 40411 | 63915641 |
Intermittent claudication | 28.92 | 10.35 | 73 | 542607 | 2981 | 63953071 |
Cytomegalovirus viraemia | 28.91 | 10.35 | 29 | 542651 | 10799 | 63945253 |
Cardiomyopathy | 28.62 | 10.35 | 333 | 542347 | 25023 | 63931029 |
Pain in extremity | 28.54 | 10.35 | 2940 | 539740 | 300145 | 63655907 |
Human herpesvirus 6 infection | 28.45 | 10.35 | 3 | 542677 | 4651 | 63951401 |
Cardiac aneurysm | 28.21 | 10.35 | 44 | 542636 | 1255 | 63954797 |
Head injury | 28.12 | 10.35 | 410 | 542270 | 32432 | 63923620 |
Myasthenia gravis | 28.05 | 10.35 | 109 | 542571 | 5629 | 63950423 |
Therapy partial responder | 27.88 | 10.35 | 27 | 542653 | 10221 | 63945831 |
Palmar-plantar erythrodysaesthesia syndrome | 27.85 | 10.35 | 136 | 542544 | 28683 | 63927369 |
Labile blood pressure | 27.81 | 10.35 | 57 | 542623 | 2023 | 63954029 |
Neuroleptic malignant syndrome | 27.75 | 10.35 | 112 | 542568 | 24884 | 63931168 |
Sensory loss | 27.62 | 10.35 | 163 | 542517 | 10006 | 63946046 |
Duodenal ulcer | 27.56 | 10.35 | 212 | 542468 | 14223 | 63941829 |
Pericardial haemorrhage | 27.52 | 10.35 | 87 | 542593 | 4049 | 63952003 |
Carotid artery disease | 27.43 | 10.35 | 58 | 542622 | 2105 | 63953947 |
Angiopathy | 27.43 | 10.35 | 115 | 542565 | 6150 | 63949902 |
Food allergy | 27.37 | 10.35 | 16 | 542664 | 7835 | 63948217 |
Flatulence | 27.36 | 10.35 | 437 | 542243 | 35229 | 63920823 |
Lower gastrointestinal haemorrhage | 27.33 | 10.35 | 206 | 542474 | 13733 | 63942319 |
Mobility decreased | 27.33 | 10.35 | 533 | 542147 | 85307 | 63870745 |
Spur cell anaemia | 27.31 | 10.35 | 14 | 542666 | 78 | 63955974 |
Hypercholesterolaemia | 27.28 | 10.35 | 222 | 542458 | 15151 | 63940901 |
Heavy menstrual bleeding | 27.24 | 10.35 | 37 | 542643 | 12040 | 63944012 |
Injection site bruising | 26.93 | 10.35 | 187 | 542493 | 36186 | 63919866 |
Sinus bradycardia | 26.90 | 10.35 | 303 | 542377 | 22590 | 63933462 |
Disability | 26.74 | 10.35 | 38 | 542642 | 12134 | 63943918 |
Injection site warmth | 26.73 | 10.35 | 45 | 542635 | 13417 | 63942635 |
Drug withdrawal syndrome | 26.71 | 10.35 | 154 | 542526 | 31137 | 63924915 |
Oral herpes | 26.70 | 10.35 | 96 | 542584 | 22056 | 63933996 |
Degenerative mitral valve disease | 26.65 | 10.35 | 20 | 542660 | 237 | 63955815 |
Tachycardia | 26.61 | 10.35 | 1009 | 541671 | 148570 | 63807482 |
Acne | 26.53 | 10.35 | 102 | 542578 | 22979 | 63933073 |
Suicidal ideation | 26.42 | 10.35 | 397 | 542283 | 66145 | 63889907 |
Metastases to central nervous system | 26.27 | 10.35 | 48 | 542632 | 13864 | 63942188 |
Drug tolerance decreased | 26.25 | 10.35 | 13 | 542667 | 6985 | 63949067 |
Akathisia | 26.23 | 10.35 | 35 | 542645 | 11475 | 63944577 |
Scrotal pain | 26.12 | 10.35 | 25 | 542655 | 422 | 63955630 |
Incorrect route of product administration | 26.11 | 10.35 | 104 | 542576 | 23194 | 63932858 |
Cytomegalovirus infection reactivation | 26.03 | 10.35 | 8 | 542672 | 5748 | 63950304 |
Neutropenic colitis | 25.48 | 10.35 | 4 | 542676 | 4577 | 63951475 |
Appendicitis | 25.46 | 10.35 | 47 | 542633 | 13522 | 63942530 |
Penile haemorrhage | 25.26 | 10.35 | 26 | 542654 | 481 | 63955571 |
Genital swelling | 25.18 | 10.35 | 21 | 542659 | 293 | 63955759 |
Agitation | 25.10 | 10.35 | 559 | 542121 | 87808 | 63868244 |
Poisoning deliberate | 24.91 | 10.35 | 47 | 542633 | 13411 | 63942641 |
Cardiac valve disease | 24.84 | 10.35 | 98 | 542582 | 5097 | 63950955 |
Clostridium difficile infection | 24.81 | 10.35 | 190 | 542490 | 35973 | 63920079 |
Eructation | 24.76 | 10.35 | 147 | 542533 | 9044 | 63947008 |
Psoriasis | 24.74 | 10.35 | 784 | 541896 | 70919 | 63885133 |
Nocardiosis | 24.70 | 10.35 | 5 | 542675 | 4762 | 63951290 |
Type 2 diabetes mellitus | 24.67 | 10.35 | 413 | 542267 | 33607 | 63922445 |
Stenosis | 24.58 | 10.35 | 50 | 542630 | 1765 | 63954287 |
Interstitial lung disease | 24.53 | 10.35 | 1031 | 541649 | 96701 | 63859351 |
Balance disorder | 24.50 | 10.35 | 900 | 541780 | 83026 | 63873026 |
Complication of device insertion | 24.47 | 10.35 | 6 | 542674 | 5006 | 63951046 |
Dermatitis atopic | 24.40 | 10.35 | 80 | 542600 | 3796 | 63952256 |
Grip strength decreased | 24.40 | 10.35 | 38 | 542642 | 11686 | 63944366 |
Menstruation irregular | 24.38 | 10.35 | 4 | 542676 | 4431 | 63951621 |
Inclusion body myositis | 24.34 | 10.35 | 8 | 542672 | 9 | 63956043 |
Depressed level of consciousness | 24.33 | 10.35 | 511 | 542169 | 80925 | 63875127 |
Basal ganglia haemorrhage | 24.33 | 10.35 | 43 | 542637 | 1363 | 63954689 |
Epistaxis | 24.13 | 10.35 | 1033 | 541647 | 97098 | 63858954 |
Pneumatosis intestinalis | 24.13 | 10.35 | 7 | 542673 | 5222 | 63950830 |
Herpes simplex | 24.05 | 10.35 | 32 | 542648 | 10504 | 63945548 |
Cell death | 24.04 | 10.35 | 82 | 542598 | 3972 | 63952080 |
Arterial occlusive disease | 24.02 | 10.35 | 120 | 542560 | 6913 | 63949139 |
Cardiogenic shock | 24.01 | 10.35 | 395 | 542285 | 32032 | 63924020 |
Septic shock | 23.77 | 10.35 | 690 | 541990 | 104747 | 63851305 |
Tuberculosis | 23.72 | 10.35 | 46 | 542634 | 12992 | 63943060 |
Quadriparesis | 23.70 | 10.35 | 65 | 542615 | 2792 | 63953260 |
Hypertension | 23.70 | 10.35 | 2510 | 540170 | 256751 | 63699301 |
Post viral fatigue syndrome | 23.69 | 10.35 | 20 | 542660 | 284 | 63955768 |
Encephalopathy | 23.67 | 10.35 | 350 | 542330 | 58469 | 63897583 |
Gastritis erosive | 23.66 | 10.35 | 150 | 542530 | 9445 | 63946607 |
Acute lymphocytic leukaemia recurrent | 23.60 | 10.35 | 3 | 542677 | 4023 | 63952029 |
Diabetic foot | 23.58 | 10.35 | 67 | 542613 | 2938 | 63953114 |
Aggression | 23.46 | 10.35 | 262 | 542418 | 45970 | 63910082 |
Aldolase increased | 23.40 | 10.35 | 18 | 542662 | 222 | 63955830 |
Neuropathy peripheral | 23.36 | 10.35 | 782 | 541898 | 116743 | 63839309 |
Tongue oedema | 23.21 | 10.35 | 106 | 542574 | 5884 | 63950168 |
Prostatomegaly | 23.13 | 10.35 | 66 | 542614 | 2901 | 63953151 |
Blood parathyroid hormone decreased | 22.99 | 10.35 | 17 | 542663 | 7349 | 63948703 |
Diabetic retinopathy | 22.96 | 10.35 | 64 | 542616 | 2775 | 63953277 |
Therapy non-responder | 22.90 | 10.35 | 403 | 542277 | 65496 | 63890556 |
Nodule | 22.83 | 10.35 | 76 | 542604 | 17871 | 63938181 |
Urinary tract obstruction | 22.73 | 10.35 | 80 | 542600 | 3937 | 63952115 |
Lichen planopilaris | 22.72 | 10.35 | 6 | 542674 | 0 | 63956052 |
Blood electrolytes abnormal | 22.68 | 10.35 | 48 | 542632 | 1743 | 63954309 |
Blood creatine phosphokinase abnormal | 22.67 | 10.35 | 22 | 542658 | 378 | 63955674 |
Ketoacidosis | 22.67 | 10.35 | 116 | 542564 | 6747 | 63949305 |
Ageusia | 22.66 | 10.35 | 196 | 542484 | 13617 | 63942435 |
Diabetic metabolic decompensation | 22.56 | 10.35 | 62 | 542618 | 2666 | 63953386 |
Urticaria | 22.54 | 10.35 | 1011 | 541669 | 146306 | 63809746 |
Juvenile idiopathic arthritis | 22.48 | 10.35 | 3 | 542677 | 3876 | 63952176 |
Benign prostatic hyperplasia | 22.43 | 10.35 | 143 | 542537 | 9022 | 63947030 |
Gait disturbance | 22.37 | 10.35 | 1710 | 540970 | 170445 | 63785607 |
Dementia | 22.24 | 10.35 | 270 | 542410 | 20496 | 63935556 |
Blood pressure fluctuation | 22.16 | 10.35 | 305 | 542375 | 51566 | 63904486 |
Carotid arteriosclerosis | 22.15 | 10.35 | 52 | 542628 | 2027 | 63954025 |
Diverticulum | 22.03 | 10.35 | 188 | 542492 | 13010 | 63943042 |
Multiple organ dysfunction syndrome | 22.03 | 10.35 | 667 | 542013 | 100746 | 63855306 |
Penis injury | 22.02 | 10.35 | 14 | 542666 | 124 | 63955928 |
Lipoprotein (a) increased | 21.94 | 10.35 | 11 | 542669 | 58 | 63955994 |
Vertigo | 21.89 | 10.35 | 651 | 542029 | 58360 | 63897692 |
Pseudomonas infection | 21.89 | 10.35 | 77 | 542603 | 17806 | 63938246 |
Adrenal insufficiency | 21.79 | 10.35 | 106 | 542574 | 22381 | 63933671 |
Metastases to bone | 21.79 | 10.35 | 93 | 542587 | 20342 | 63935710 |
Hepatic encephalopathy | 21.78 | 10.35 | 97 | 542583 | 20969 | 63935083 |
Dyspnoea at rest | 21.62 | 10.35 | 108 | 542572 | 6221 | 63949831 |
Acquired claw toe | 21.55 | 10.35 | 12 | 542668 | 81 | 63955971 |
Brain oedema | 21.43 | 10.35 | 104 | 542576 | 21971 | 63934081 |
Product complaint | 21.41 | 10.35 | 173 | 542507 | 11781 | 63944271 |
Neutropenic sepsis | 21.25 | 10.35 | 112 | 542568 | 23160 | 63932892 |
Intraventricular haemorrhage | 21.21 | 10.35 | 80 | 542600 | 4073 | 63951979 |
Injection site rash | 21.19 | 10.35 | 65 | 542615 | 15677 | 63940375 |
Retinal artery occlusion | 21.12 | 10.35 | 63 | 542617 | 2840 | 63953212 |
Abnormal weight gain | 21.06 | 10.35 | 53 | 542627 | 2160 | 63953892 |
Generalised tonic-clonic seizure | 20.97 | 10.35 | 224 | 542456 | 39633 | 63916419 |
Ventricular tachycardia | 20.97 | 10.35 | 405 | 542275 | 33860 | 63922192 |
Muscle haemorrhage | 20.97 | 10.35 | 100 | 542580 | 5653 | 63950399 |
Acute left ventricular failure | 20.95 | 10.35 | 40 | 542640 | 1347 | 63954705 |
Staphylococcal infection | 20.94 | 10.35 | 300 | 542380 | 50378 | 63905674 |
Pulmonary vascular disorder | 20.92 | 10.35 | 32 | 542648 | 897 | 63955155 |
Ovarian cyst | 20.82 | 10.35 | 38 | 542642 | 10980 | 63945072 |
Restlessness | 20.77 | 10.35 | 224 | 542456 | 39561 | 63916491 |
Hypercalcaemia | 20.65 | 10.35 | 167 | 542513 | 31249 | 63924803 |
Temperature regulation disorder | 20.64 | 10.35 | 5 | 542675 | 4206 | 63951846 |
Joint destruction | 20.63 | 10.35 | 3 | 542677 | 3633 | 63952419 |
Stillbirth | 20.60 | 10.35 | 3 | 542677 | 3630 | 63952422 |
Dysuria | 20.53 | 10.35 | 481 | 542199 | 41576 | 63914476 |
Blood cholesterol | 20.50 | 10.35 | 20 | 542660 | 346 | 63955706 |
Status epilepticus | 20.49 | 10.35 | 103 | 542577 | 21560 | 63934492 |
Arterial insufficiency | 20.47 | 10.35 | 19 | 542661 | 308 | 63955744 |
Chest discomfort | 20.40 | 10.35 | 1183 | 541497 | 114923 | 63841129 |
Traumatic coma | 20.37 | 10.35 | 10 | 542670 | 50 | 63956002 |
Drug specific antibody present | 20.21 | 10.35 | 9 | 542671 | 5145 | 63950907 |
Macroglossia | 20.14 | 10.35 | 34 | 542646 | 1038 | 63955014 |
Neuromyopathy | 20.10 | 10.35 | 39 | 542641 | 1329 | 63954723 |
Vascular purpura | 20.07 | 10.35 | 57 | 542623 | 2499 | 63953553 |
Lacunar infarction | 20.04 | 10.35 | 96 | 542584 | 5436 | 63950616 |
Coronary artery surgery | 20.04 | 10.35 | 15 | 542665 | 177 | 63955875 |
Hepatitis B reactivation | 20.04 | 10.35 | 8 | 542672 | 4881 | 63951171 |
Eating disorder | 20.00 | 10.35 | 223 | 542457 | 16582 | 63939470 |
Infarction | 19.99 | 10.35 | 76 | 542604 | 3884 | 63952168 |
Agitated depression | 19.94 | 10.35 | 18 | 542662 | 281 | 63955771 |
Crying | 19.88 | 10.35 | 94 | 542586 | 19996 | 63936056 |
Urinary tract discomfort | 19.74 | 10.35 | 19 | 542661 | 323 | 63955729 |
Chest wall haematoma | 19.73 | 10.35 | 20 | 542660 | 363 | 63955689 |
Transaminases increased | 19.66 | 10.35 | 503 | 542177 | 44091 | 63911961 |
Bacterial infection | 19.61 | 10.35 | 126 | 542554 | 24824 | 63931228 |
Central obesity | 19.60 | 10.35 | 40 | 542640 | 1415 | 63954637 |
Obstructive pancreatitis | 19.60 | 10.35 | 26 | 542654 | 637 | 63955415 |
Hyperprolactinaemia | 19.59 | 10.35 | 5 | 542675 | 4060 | 63951992 |
Polyuria | 19.50 | 10.35 | 177 | 542503 | 12466 | 63943586 |
Vascular graft occlusion | 19.48 | 10.35 | 26 | 542654 | 641 | 63955411 |
Gastrointestinal angiodysplasia | 19.43 | 10.35 | 31 | 542649 | 902 | 63955150 |
Inappropriate antidiuretic hormone secretion | 19.37 | 10.35 | 279 | 542401 | 22010 | 63934042 |
Hepatojugular reflux | 19.30 | 10.35 | 23 | 542657 | 504 | 63955548 |
Metastases to liver | 19.28 | 10.35 | 120 | 542560 | 23821 | 63932231 |
Narrow anterior chamber angle | 19.22 | 10.35 | 14 | 542666 | 158 | 63955894 |
Klebsiella infection | 19.21 | 10.35 | 53 | 542627 | 13228 | 63942824 |
Anticoagulation drug level increased | 19.11 | 10.35 | 26 | 542654 | 653 | 63955399 |
Vascular stent occlusion | 19.10 | 10.35 | 15 | 542665 | 191 | 63955861 |
Peripheral artery occlusion | 19.10 | 10.35 | 50 | 542630 | 2088 | 63953964 |
Lacunar stroke | 19.06 | 10.35 | 17 | 542663 | 261 | 63955791 |
Hypogammaglobulinaemia | 19.03 | 10.35 | 36 | 542644 | 10263 | 63945789 |
Bundle branch block left | 18.95 | 10.35 | 147 | 542533 | 9887 | 63946165 |
Blood pressure increased | 18.91 | 10.35 | 1692 | 540988 | 170860 | 63785192 |
Myoglobinaemia | 18.90 | 10.35 | 12 | 542668 | 106 | 63955946 |
Sopor | 18.89 | 10.35 | 159 | 542521 | 29502 | 63926550 |
Memory impairment | 18.89 | 10.35 | 892 | 541788 | 84790 | 63871262 |
Aortic valve incompetence | 18.78 | 10.35 | 127 | 542553 | 8174 | 63947878 |
Cytopenia | 18.68 | 10.35 | 67 | 542613 | 15404 | 63940648 |
Primary biliary cholangitis | 18.67 | 10.35 | 32 | 542648 | 989 | 63955063 |
Decreased appetite | 18.62 | 10.35 | 2669 | 540011 | 278620 | 63677432 |
AST/ALT ratio abnormal | 18.61 | 10.35 | 7 | 542673 | 15 | 63956037 |
Occupational problem environmental | 18.61 | 10.35 | 6 | 542674 | 6 | 63956046 |
Avoidant personality disorder | 18.61 | 10.35 | 6 | 542674 | 6 | 63956046 |
Catatonia | 18.58 | 10.35 | 22 | 542658 | 7598 | 63948454 |
Embolic stroke | 18.51 | 10.35 | 108 | 542572 | 6603 | 63949449 |
Cholecystitis chronic | 18.48 | 10.35 | 31 | 542649 | 9256 | 63946796 |
Hallucination, gustatory | 18.39 | 10.35 | 10 | 542670 | 64 | 63955988 |
Device difficult to use | 18.33 | 10.35 | 34 | 542646 | 9764 | 63946288 |
Thrombotic microangiopathy | 18.25 | 10.35 | 75 | 542605 | 16580 | 63939472 |
Atrial enlargement | 18.17 | 10.35 | 25 | 542655 | 635 | 63955417 |
Alveolar osteitis | 18.12 | 10.35 | 20 | 542660 | 402 | 63955650 |
Escherichia infection | 18.10 | 10.35 | 66 | 542614 | 15102 | 63940950 |
Respiratory failure | 18.09 | 10.35 | 1141 | 541539 | 160042 | 63796010 |
Diabetic neuropathy | 18.03 | 10.35 | 94 | 542586 | 5507 | 63950545 |
Aortic valve replacement | 18.01 | 10.35 | 34 | 542646 | 1135 | 63954917 |
Cervix neoplasm | 17.98 | 10.35 | 14 | 542666 | 176 | 63955876 |
Motor dysfunction | 17.94 | 10.35 | 160 | 542520 | 11213 | 63944839 |
Atrioventricular block second degree | 17.89 | 10.35 | 104 | 542576 | 6350 | 63949702 |
Glycogen storage disease type V | 17.88 | 10.35 | 8 | 542672 | 31 | 63956021 |
Transplant dysfunction | 17.87 | 10.35 | 18 | 542662 | 6690 | 63949362 |
Myoglobinuria | 17.84 | 10.35 | 31 | 542649 | 969 | 63955083 |
Dyslipidaemia | 17.79 | 10.35 | 136 | 542544 | 9106 | 63946946 |
Arrhythmia | 17.77 | 10.35 | 577 | 542103 | 52367 | 63903685 |
Weight increased | 17.75 | 10.35 | 1549 | 541131 | 211799 | 63744253 |
Cardiovascular disorder | 17.67 | 10.35 | 208 | 542472 | 15673 | 63940379 |
Deafness | 17.66 | 10.35 | 234 | 542446 | 18125 | 63937927 |
Periorbital haematoma | 17.61 | 10.35 | 29 | 542651 | 867 | 63955185 |
Pulmonary tuberculosis | 17.58 | 10.35 | 21 | 542659 | 7223 | 63948829 |
Atrial thrombosis | 17.57 | 10.35 | 61 | 542619 | 2981 | 63953071 |
Gastroduodenal haemorrhage | 17.56 | 10.35 | 16 | 542664 | 253 | 63955799 |
Potassium wasting nephropathy | 17.54 | 10.35 | 13 | 542667 | 151 | 63955901 |
Coeliac disease | 17.44 | 10.35 | 22 | 542658 | 7390 | 63948662 |
Gastritis | 17.43 | 10.35 | 476 | 542204 | 42142 | 63913910 |
Injection site haemorrhage | 17.40 | 10.35 | 126 | 542554 | 24152 | 63931900 |
Orthopnoea | 17.35 | 10.35 | 134 | 542546 | 9000 | 63947052 |
Body height decreased | 17.35 | 10.35 | 116 | 542564 | 7438 | 63948614 |
Left atrial dilatation | 17.33 | 10.35 | 57 | 542623 | 2709 | 63953343 |
Muscle fatigue | 17.31 | 10.35 | 61 | 542619 | 3004 | 63953048 |
Essential hypertension | 17.30 | 10.35 | 88 | 542592 | 5106 | 63950946 |
ECG signs of myocardial ischaemia | 17.15 | 10.35 | 18 | 542662 | 341 | 63955711 |
Peripheral ischaemia | 17.10 | 10.35 | 125 | 542555 | 8253 | 63947799 |
Pollakiuria | 17.08 | 10.35 | 366 | 542314 | 31164 | 63924888 |
Dyspnoea paroxysmal nocturnal | 17.03 | 10.35 | 46 | 542634 | 1958 | 63954094 |
Blood alkaline phosphatase increased | 17.03 | 10.35 | 606 | 542074 | 55673 | 63900379 |
Pelvic mass | 16.95 | 10.35 | 32 | 542648 | 1068 | 63954984 |
Ventricular dyskinesia | 16.94 | 10.35 | 19 | 542661 | 389 | 63955663 |
Angiocardiogram | 16.94 | 10.35 | 15 | 542665 | 228 | 63955824 |
Diffuse large B-cell lymphoma recurrent | 16.94 | 10.35 | 3 | 542677 | 3143 | 63952909 |
Lichenoid keratosis | 16.84 | 10.35 | 64 | 542616 | 3270 | 63952782 |
Oligohydramnios | 16.77 | 10.35 | 3 | 542677 | 3121 | 63952931 |
Hepatocellular carcinoma | 16.77 | 10.35 | 28 | 542652 | 8375 | 63947677 |
Anuria | 16.73 | 10.35 | 238 | 542442 | 18726 | 63937326 |
Hepatic vein dilatation | 16.67 | 10.35 | 15 | 542665 | 233 | 63955819 |
Iliac artery stenosis | 16.62 | 10.35 | 11 | 542669 | 105 | 63955947 |
Blood lactic acid | 16.61 | 10.35 | 20 | 542660 | 443 | 63955609 |
Pulmonary valve incompetence | 16.60 | 10.35 | 40 | 542640 | 1586 | 63954466 |
Blood creatine increased | 16.59 | 10.35 | 122 | 542558 | 8070 | 63947982 |
Spinal epidural haematoma | 16.56 | 10.35 | 34 | 542646 | 1208 | 63954844 |
Dysstasia | 16.53 | 10.35 | 281 | 542399 | 22934 | 63933118 |
Creatinine renal clearance decreased | 16.40 | 10.35 | 64 | 542616 | 14357 | 63941695 |
Multiple injuries | 16.40 | 10.35 | 63 | 542617 | 3236 | 63952816 |
Gastric ulcer | 16.39 | 10.35 | 351 | 542329 | 29883 | 63926169 |
Pneumonia cytomegaloviral | 16.36 | 10.35 | 8 | 542672 | 4331 | 63951721 |
Penile pain | 16.30 | 10.35 | 28 | 542652 | 867 | 63955185 |
Glomerular filtration rate abnormal | 16.24 | 10.35 | 34 | 542646 | 1225 | 63954827 |
Blood potassium increased | 16.21 | 10.35 | 308 | 542372 | 25672 | 63930380 |
Coronary artery thrombosis | 16.12 | 10.35 | 57 | 542623 | 2812 | 63953240 |
Haematoma muscle | 16.09 | 10.35 | 42 | 542638 | 1751 | 63954301 |
Lymphadenopathy | 16.06 | 10.35 | 286 | 542394 | 46400 | 63909652 |
Affect lability | 16.04 | 10.35 | 130 | 542550 | 8860 | 63947192 |
Skin necrosis | 16.04 | 10.35 | 64 | 542616 | 14265 | 63941787 |
Blood glucose abnormal | 15.97 | 10.35 | 129 | 542551 | 8784 | 63947268 |
Cardiac pacemaker insertion | 15.97 | 10.35 | 84 | 542596 | 4939 | 63951113 |
Ludwig angina | 15.96 | 10.35 | 14 | 542666 | 210 | 63955842 |
Therapeutic drug monitoring analysis not performed | 15.95 | 10.35 | 33 | 542647 | 1179 | 63954873 |
Occult blood positive | 15.95 | 10.35 | 99 | 542581 | 6188 | 63949864 |
Ventricular internal diameter abnormal | 15.94 | 10.35 | 12 | 542668 | 143 | 63955909 |
Ventricular extrasystoles | 15.87 | 10.35 | 221 | 542459 | 17308 | 63938744 |
Prostate cancer recurrent | 15.85 | 10.35 | 25 | 542655 | 720 | 63955332 |
Peripheral nerve palsy | 15.83 | 10.35 | 8 | 542672 | 43 | 63956009 |
Hepatosplenomegaly | 15.83 | 10.35 | 13 | 542667 | 5330 | 63950722 |
Gastric ulcer haemorrhage | 15.77 | 10.35 | 120 | 542560 | 8023 | 63948029 |
Drug screen positive | 15.69 | 10.35 | 15 | 542665 | 5714 | 63950338 |
Electrolyte imbalance | 15.66 | 10.35 | 299 | 542381 | 24944 | 63931108 |
Blood cholesterol increased | 15.62 | 10.35 | 541 | 542139 | 49525 | 63906527 |
Hypoalbuminaemia | 15.61 | 10.35 | 86 | 542594 | 17588 | 63938464 |
Ear infection | 15.57 | 10.35 | 124 | 542556 | 23280 | 63932772 |
Eye injury | 15.57 | 10.35 | 39 | 542641 | 1585 | 63954467 |
Vaginal haemorrhage | 15.56 | 10.35 | 97 | 542583 | 19247 | 63936805 |
Intracranial haematoma | 15.56 | 10.35 | 26 | 542654 | 787 | 63955265 |
Pain in jaw | 15.55 | 10.35 | 245 | 542435 | 40510 | 63915542 |
Autoimmune myocarditis | 15.49 | 10.35 | 15 | 542665 | 257 | 63955795 |
Drug tolerance | 15.46 | 10.35 | 17 | 542663 | 6068 | 63949984 |
Device use error | 15.44 | 10.35 | 19 | 542661 | 6452 | 63949600 |
Radiculitis brachial | 15.44 | 10.35 | 9 | 542671 | 67 | 63955985 |
Disease recurrence | 15.43 | 10.35 | 180 | 542500 | 31330 | 63924722 |
Renal injury | 15.41 | 10.35 | 198 | 542482 | 15231 | 63940821 |
Urinary occult blood positive | 15.40 | 10.35 | 12 | 542668 | 151 | 63955901 |
Intestinal haemorrhage | 15.38 | 10.35 | 89 | 542591 | 5425 | 63950627 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 15.36 | 10.35 | 57 | 542623 | 2879 | 63953173 |
Clonus | 15.36 | 10.35 | 17 | 542663 | 6050 | 63950002 |
Diverticulum intestinal | 15.31 | 10.35 | 111 | 542569 | 7309 | 63948743 |
Hepatitis B | 15.28 | 10.35 | 26 | 542654 | 7719 | 63948333 |
Heart valve incompetence | 15.27 | 10.35 | 55 | 542625 | 2738 | 63953314 |
Blood sodium decreased | 15.26 | 10.35 | 340 | 542340 | 29142 | 63926910 |
Upper respiratory tract infection | 15.25 | 10.35 | 481 | 542199 | 72304 | 63883748 |
Bilirubin conjugated abnormal | 15.24 | 10.35 | 10 | 542670 | 94 | 63955958 |
Blood creatinine abnormal | 15.23 | 10.35 | 72 | 542608 | 4055 | 63951997 |
Subacute cutaneous lupus erythematosus | 15.23 | 10.35 | 58 | 542622 | 2967 | 63953085 |
Nodular rash | 15.21 | 10.35 | 16 | 542664 | 304 | 63955748 |
Second primary malignancy | 15.18 | 10.35 | 53 | 542627 | 12284 | 63943768 |
Vascular graft | 15.13 | 10.35 | 42 | 542638 | 1817 | 63954235 |
Cerebral microangiopathy | 15.13 | 10.35 | 14 | 542666 | 226 | 63955826 |
Blood pressure inadequately controlled | 15.08 | 10.35 | 87 | 542593 | 5297 | 63950755 |
Joint range of motion decreased | 15.04 | 10.35 | 98 | 542582 | 19245 | 63936807 |
Mitral valve calcification | 14.96 | 10.35 | 35 | 542645 | 1361 | 63954691 |
Vascular device infection | 14.90 | 10.35 | 18 | 542662 | 6162 | 63949890 |
Hepatic ischaemia | 14.85 | 10.35 | 29 | 542651 | 993 | 63955059 |
Dilatation atrial | 14.85 | 10.35 | 63 | 542617 | 3387 | 63952665 |
Leukocyturia | 14.81 | 10.35 | 37 | 542643 | 1501 | 63954551 |
Rhinovirus infection | 14.77 | 10.35 | 18 | 542662 | 6138 | 63949914 |
Parainfluenzae virus infection | 14.73 | 10.35 | 11 | 542669 | 4732 | 63951320 |
Product odour abnormal | 14.72 | 10.35 | 31 | 542649 | 1122 | 63954930 |
Sarcopenia | 14.71 | 10.35 | 17 | 542663 | 360 | 63955692 |
Cold sweat | 14.71 | 10.35 | 207 | 542473 | 16248 | 63939804 |
Calcium deficiency | 14.66 | 10.35 | 24 | 542656 | 714 | 63955338 |
Pruritus genital | 14.66 | 10.35 | 29 | 542651 | 1003 | 63955049 |
Rectal polyp | 14.65 | 10.35 | 33 | 542647 | 1251 | 63954801 |
Encephalitis toxic | 14.64 | 10.35 | 15 | 542665 | 276 | 63955776 |
Rales | 14.61 | 10.35 | 194 | 542486 | 15035 | 63941017 |
Muscle relaxant therapy | 14.59 | 10.35 | 12 | 542668 | 164 | 63955888 |
Sinus node dysfunction | 14.59 | 10.35 | 103 | 542577 | 6725 | 63949327 |
Penile discharge | 14.58 | 10.35 | 7 | 542673 | 33 | 63956019 |
Device deployment issue | 14.57 | 10.35 | 3 | 542677 | 2823 | 63953229 |
Aortic valve thickening | 14.55 | 10.35 | 6 | 542674 | 18 | 63956034 |
Collagen disorder | 14.50 | 10.35 | 14 | 542666 | 239 | 63955813 |
Fear of injection | 14.49 | 10.35 | 17 | 542663 | 5895 | 63950157 |
Drug level decreased | 14.43 | 10.35 | 49 | 542631 | 11454 | 63944598 |
Glycosylated haemoglobin abnormal | 14.41 | 10.35 | 11 | 542669 | 134 | 63955918 |
Conjunctivitis | 14.41 | 10.35 | 106 | 542574 | 20248 | 63935804 |
Lymphoproliferative disorder | 14.41 | 10.35 | 13 | 542667 | 5090 | 63950962 |
Mood swings | 14.36 | 10.35 | 87 | 542593 | 17381 | 63938671 |
Bladder sphincter atony | 14.32 | 10.35 | 10 | 542670 | 105 | 63955947 |
Injection site extravasation | 14.31 | 10.35 | 29 | 542651 | 8057 | 63947995 |
Peroneal nerve injury | 14.24 | 10.35 | 8 | 542672 | 55 | 63955997 |
Prostatic operation | 14.24 | 10.35 | 13 | 542667 | 206 | 63955846 |
Helicobacter test positive | 14.23 | 10.35 | 29 | 542651 | 1025 | 63955027 |
Hallucinations, mixed | 14.20 | 10.35 | 18 | 542662 | 6034 | 63950018 |
Infective exacerbation of chronic obstructive airways disease | 14.18 | 10.35 | 49 | 542631 | 2389 | 63953663 |
Aortic valve stenosis | 14.15 | 10.35 | 76 | 542604 | 4504 | 63951548 |
Benign gastrointestinal neoplasm | 14.14 | 10.35 | 11 | 542669 | 138 | 63955914 |
Liver palpable | 14.14 | 10.35 | 16 | 542664 | 331 | 63955721 |
Skin toxicity | 14.12 | 10.35 | 21 | 542659 | 6581 | 63949471 |
Metabolic acidosis | 14.04 | 10.35 | 731 | 541949 | 70227 | 63885825 |
Pelvic pain | 14.02 | 10.35 | 46 | 542634 | 10864 | 63945188 |
Abnormal dreams | 14.00 | 10.35 | 141 | 542539 | 10215 | 63945837 |
Blood iron decreased | 13.94 | 10.35 | 160 | 542520 | 11982 | 63944070 |
Blood creatinine increased | 13.90 | 10.35 | 1325 | 541355 | 134457 | 63821595 |
Product administered to patient of inappropriate age | 13.87 | 10.35 | 11 | 542669 | 4590 | 63951462 |
Iron deficiency anaemia | 13.83 | 10.35 | 260 | 542420 | 21629 | 63934423 |
Subchondral insufficiency fracture | 13.79 | 10.35 | 8 | 542672 | 59 | 63955993 |
Pulmonary haemorrhage | 13.77 | 10.35 | 60 | 542620 | 13049 | 63943003 |
Acute lymphocytic leukaemia | 13.76 | 10.35 | 10 | 542670 | 4361 | 63951691 |
Tobacco abuse | 13.74 | 10.35 | 25 | 542655 | 811 | 63955241 |
Brain stem haematoma | 13.72 | 10.35 | 10 | 542670 | 113 | 63955939 |
Sitting disability | 13.70 | 10.35 | 11 | 542669 | 145 | 63955907 |
Prothrombin consumption time prolonged | 13.65 | 10.35 | 7 | 542673 | 39 | 63956013 |
Non-cardiac chest pain | 13.64 | 10.35 | 122 | 542558 | 8558 | 63947494 |
Accelerated hypertension | 13.62 | 10.35 | 21 | 542659 | 593 | 63955459 |
Lipids increased | 13.55 | 10.35 | 34 | 542646 | 1383 | 63954669 |
Right ventricular enlargement | 13.53 | 10.35 | 19 | 542661 | 492 | 63955560 |
Cough decreased | 13.52 | 10.35 | 5 | 542675 | 10 | 63956042 |
Blood testosterone decreased | 13.50 | 10.35 | 44 | 542636 | 2081 | 63953971 |
Discoloured vomit | 13.50 | 10.35 | 30 | 542650 | 1127 | 63954925 |
Lymph node calcification | 13.50 | 10.35 | 15 | 542665 | 304 | 63955748 |
Meningitis aseptic | 13.49 | 10.35 | 17 | 542663 | 5713 | 63950339 |
Left ventricular dysfunction | 13.48 | 10.35 | 209 | 542471 | 16745 | 63939307 |
Wrong technique in product usage process | 13.46 | 10.35 | 430 | 542250 | 64544 | 63891508 |
Quadrantanopia | 13.41 | 10.35 | 12 | 542668 | 185 | 63955867 |
Coronary angioplasty | 13.41 | 10.35 | 16 | 542664 | 351 | 63955701 |
Device breakage | 13.38 | 10.35 | 34 | 542646 | 8721 | 63947331 |
Stevens-Johnson syndrome | 13.36 | 10.35 | 205 | 542475 | 34044 | 63922008 |
Ankylosing spondylitis | 13.35 | 10.35 | 31 | 542649 | 8203 | 63947849 |
Duodenal ulcer haemorrhage | 13.27 | 10.35 | 95 | 542585 | 6230 | 63949822 |
Haemoglobin increased | 13.26 | 10.35 | 82 | 542598 | 5119 | 63950933 |
Photophobia | 13.25 | 10.35 | 88 | 542592 | 17205 | 63938847 |
Normocytic anaemia | 13.25 | 10.35 | 59 | 542621 | 3240 | 63952812 |
Burning feet syndrome | 13.22 | 10.35 | 10 | 542670 | 120 | 63955932 |
Anal abscess | 13.22 | 10.35 | 27 | 542653 | 7481 | 63948571 |
Internal haemorrhage | 13.22 | 10.35 | 110 | 542570 | 7557 | 63948495 |
Decreased gait velocity | 13.22 | 10.35 | 11 | 542669 | 153 | 63955899 |
Thrombotic thrombocytopenic purpura | 13.21 | 10.35 | 91 | 542589 | 5893 | 63950159 |
Ear congestion | 13.20 | 10.35 | 44 | 542636 | 2106 | 63953946 |
Ecchymosis | 13.19 | 10.35 | 178 | 542502 | 13844 | 63942208 |
Prostate cancer | 13.16 | 10.35 | 237 | 542443 | 19558 | 63936494 |
Laryngeal haematoma | 13.16 | 10.35 | 11 | 542669 | 154 | 63955898 |
Subdural haemorrhage | 13.14 | 10.35 | 83 | 542597 | 5220 | 63950832 |
Pulmonary renal syndrome | 13.12 | 10.35 | 20 | 542660 | 559 | 63955493 |
Hepatitis C | 13.10 | 10.35 | 48 | 542632 | 10967 | 63945085 |
Tic | 13.05 | 10.35 | 3 | 542677 | 2616 | 63953436 |
Agonal rhythm | 13.05 | 10.35 | 8 | 542672 | 66 | 63955986 |
Respiratory acidosis | 13.04 | 10.35 | 41 | 542639 | 9814 | 63946238 |
Wound haematoma | 13.04 | 10.35 | 11 | 542669 | 156 | 63955896 |
Cholangiocarcinoma | 13.02 | 10.35 | 42 | 542638 | 1976 | 63954076 |
Kidney transplant rejection | 12.99 | 10.35 | 39 | 542641 | 9472 | 63946580 |
Hypokalaemia | 12.99 | 10.35 | 1193 | 541487 | 120710 | 63835342 |
Benign pancreatic neoplasm | 12.97 | 10.35 | 7 | 542673 | 44 | 63956008 |
Epstein-Barr virus associated lymphoproliferative disorder | 12.95 | 10.35 | 5 | 542675 | 3114 | 63952938 |
Nicotine dependence | 12.94 | 10.35 | 24 | 542656 | 790 | 63955262 |
Post stroke epilepsy | 12.93 | 10.35 | 4 | 542676 | 3 | 63956049 |
Post stroke seizure | 12.93 | 10.35 | 4 | 542676 | 3 | 63956049 |
Femoral bruit | 12.91 | 10.35 | 5 | 542675 | 12 | 63956040 |
Phimosis | 12.89 | 10.35 | 17 | 542663 | 414 | 63955638 |
Immune effector cell-associated neurotoxicity syndrome | 12.88 | 10.35 | 3 | 542677 | 2592 | 63953460 |
Toe amputation | 12.87 | 10.35 | 61 | 542619 | 3439 | 63952613 |
Pneumonia aspiration | 12.83 | 10.35 | 390 | 542290 | 58881 | 63897171 |
Blood glucose fluctuation | 12.82 | 10.35 | 90 | 542590 | 5865 | 63950187 |
Consciousness fluctuating | 12.80 | 10.35 | 36 | 542644 | 1569 | 63954483 |
BK virus infection | 12.76 | 10.35 | 27 | 542653 | 7385 | 63948667 |
Prolonged expiration | 12.76 | 10.35 | 24 | 542656 | 799 | 63955253 |
Fibrous histiocytoma | 12.76 | 10.35 | 19 | 542661 | 520 | 63955532 |
Bradyarrhythmia | 12.75 | 10.35 | 64 | 542616 | 3694 | 63952358 |
Aortic arteriosclerosis | 12.75 | 10.35 | 107 | 542573 | 7369 | 63948683 |
Primary hypoparathyroidism | 12.72 | 10.35 | 6 | 542674 | 27 | 63956025 |
Xyphoid retraction | 12.70 | 10.35 | 11 | 542669 | 162 | 63955890 |
Testicular pain | 12.62 | 10.35 | 38 | 542642 | 1722 | 63954330 |
Shock | 12.61 | 10.35 | 236 | 542444 | 38004 | 63918048 |
Urine flow decreased | 12.58 | 10.35 | 27 | 542653 | 990 | 63955062 |
Troponin T increased | 12.58 | 10.35 | 46 | 542634 | 2307 | 63953745 |
Ileus | 12.52 | 10.35 | 128 | 542552 | 22838 | 63933214 |
Arteriovenous fistula occlusion | 12.49 | 10.35 | 19 | 542661 | 530 | 63955522 |
Anaphylactic reaction | 12.47 | 10.35 | 462 | 542218 | 68202 | 63887850 |
Breast cancer metastatic | 12.44 | 10.35 | 26 | 542654 | 7143 | 63948909 |
Soft tissue disorder | 12.42 | 10.35 | 6 | 542674 | 3270 | 63952782 |
Copper metabolism disorder | 12.41 | 10.35 | 4 | 542676 | 4 | 63956048 |
Biliary fibrosis | 12.41 | 10.35 | 4 | 542676 | 4 | 63956048 |
Patient dissatisfaction with treatment | 12.38 | 10.35 | 10 | 542670 | 133 | 63955919 |
Acute myeloid leukaemia recurrent | 12.36 | 10.35 | 4 | 542676 | 2780 | 63953272 |
Blood triglycerides decreased | 12.33 | 10.35 | 11 | 542669 | 169 | 63955883 |
Carcinoid tumour of the gastrointestinal tract | 12.30 | 10.35 | 8 | 542672 | 74 | 63955978 |
Alanine aminotransferase increased | 12.26 | 10.35 | 1343 | 541337 | 137688 | 63818364 |
Tongue disorder | 12.26 | 10.35 | 56 | 542624 | 12024 | 63944028 |
Intestinal obstruction | 12.26 | 10.35 | 223 | 542457 | 36063 | 63919989 |
Pharyngitis streptococcal | 12.24 | 10.35 | 35 | 542645 | 8633 | 63947419 |
Peripheral coldness | 12.19 | 10.35 | 171 | 542509 | 13413 | 63942639 |
Pelvic cyst | 12.13 | 10.35 | 7 | 542673 | 51 | 63956001 |
Nightmare | 12.13 | 10.35 | 246 | 542434 | 20747 | 63935305 |
Atrioventricular block first degree | 12.13 | 10.35 | 141 | 542539 | 10593 | 63945459 |
Portosplenomesenteric venous thrombosis | 12.13 | 10.35 | 5 | 542675 | 15 | 63956037 |
Palpitations | 12.12 | 10.35 | 1029 | 541651 | 103459 | 63852593 |
Neurosensory hypoacusis | 12.10 | 10.35 | 12 | 542668 | 212 | 63955840 |
Toxic epidermal necrolysis | 12.06 | 10.35 | 230 | 542450 | 36936 | 63919116 |
Total cholesterol/HDL ratio increased | 12.05 | 10.35 | 12 | 542668 | 213 | 63955839 |
Secondary immunodeficiency | 11.94 | 10.35 | 4 | 542676 | 2720 | 63953332 |
Cardiac flutter | 11.93 | 10.35 | 68 | 542612 | 4121 | 63951931 |
Complication associated with device | 11.93 | 10.35 | 76 | 542604 | 15004 | 63941048 |
Device malfunction | 11.93 | 10.35 | 93 | 542587 | 17540 | 63938512 |
Scleritis | 11.92 | 10.35 | 5 | 542675 | 2961 | 63953091 |
Subcutaneous abscess | 11.89 | 10.35 | 26 | 542654 | 7027 | 63949025 |
Dizziness postural | 11.88 | 10.35 | 130 | 542550 | 9622 | 63946430 |
Asphyxia | 11.83 | 10.35 | 41 | 542639 | 9525 | 63946527 |
Haemarthrosis | 11.83 | 10.35 | 80 | 542600 | 5149 | 63950903 |
Mitochondrial toxicity | 11.81 | 10.35 | 4 | 542676 | 2702 | 63953350 |
Food interaction | 11.81 | 10.35 | 33 | 542647 | 1433 | 63954619 |
Acute pulmonary oedema | 11.80 | 10.35 | 162 | 542518 | 12647 | 63943405 |
Toxic anterior segment syndrome | 11.75 | 10.35 | 3 | 542677 | 2436 | 63953616 |
Deep vein thrombosis | 11.72 | 10.35 | 745 | 541935 | 104437 | 63851615 |
Osteoporosis | 11.71 | 10.35 | 267 | 542413 | 41813 | 63914239 |
Pneumonia fungal | 11.70 | 10.35 | 37 | 542643 | 8840 | 63947212 |
International normalised ratio abnormal | 11.70 | 10.35 | 77 | 542603 | 4911 | 63951141 |
Liver disorder | 11.67 | 10.35 | 555 | 542125 | 52796 | 63903256 |
Arthritis | 11.66 | 10.35 | 581 | 542099 | 83233 | 63872819 |
Aortic aneurysm rupture | 11.63 | 10.35 | 29 | 542651 | 1175 | 63954877 |
Haemorrhage | 11.63 | 10.35 | 796 | 541884 | 78555 | 63877497 |
Hypovolaemia | 11.60 | 10.35 | 189 | 542491 | 15297 | 63940755 |
Hiatus hernia | 11.58 | 10.35 | 234 | 542446 | 19723 | 63936329 |
Dry eye | 11.56 | 10.35 | 173 | 542507 | 28846 | 63927206 |
Erythema nodosum | 11.54 | 10.35 | 10 | 542670 | 3994 | 63952058 |
Nipple swelling | 11.53 | 10.35 | 4 | 542676 | 6 | 63956046 |
Renal disorder | 11.50 | 10.35 | 384 | 542296 | 34981 | 63921071 |
Unintended pregnancy | 11.49 | 10.35 | 6 | 542674 | 3128 | 63952924 |
Blood calcitonin increased | 11.48 | 10.35 | 6 | 542674 | 35 | 63956017 |
Dislocation of vertebra | 11.42 | 10.35 | 6 | 542674 | 3118 | 63952934 |
Device related sepsis | 11.42 | 10.35 | 16 | 542664 | 5139 | 63950913 |
Immunosuppression | 11.40 | 10.35 | 49 | 542631 | 10697 | 63945355 |
Platelet aggregation test | 11.39 | 10.35 | 7 | 542673 | 58 | 63955994 |
Mixed anxiety and depressive disorder | 11.38 | 10.35 | 11 | 542669 | 188 | 63955864 |
Onychomadesis | 11.37 | 10.35 | 5 | 542675 | 2879 | 63953173 |
Bacterial sepsis | 11.36 | 10.35 | 29 | 542651 | 7428 | 63948624 |
Wrong dosage form | 11.36 | 10.35 | 3 | 542677 | 0 | 63956052 |
Red blood cell acanthocytes present | 11.36 | 10.35 | 3 | 542677 | 0 | 63956052 |
Progressive muscular atrophy | 11.36 | 10.35 | 3 | 542677 | 0 | 63956052 |
Leukocyte alkaline phosphatase increased | 11.36 | 10.35 | 3 | 542677 | 0 | 63956052 |
Implantable cardiac monitor insertion | 11.36 | 10.35 | 3 | 542677 | 0 | 63956052 |
Aortitis salmonella | 11.36 | 10.35 | 3 | 542677 | 0 | 63956052 |
Foreign travel | 11.36 | 10.35 | 3 | 542677 | 0 | 63956052 |
Systemic candida | 11.35 | 10.35 | 17 | 542663 | 5312 | 63950740 |
Eyelid retraction | 11.35 | 10.35 | 6 | 542674 | 36 | 63956016 |
Prevertebral soft tissue swelling of cervical space | 11.35 | 10.35 | 6 | 542674 | 36 | 63956016 |
Cardiac discomfort | 11.34 | 10.35 | 27 | 542653 | 1062 | 63954990 |
Encephalitis viral | 11.33 | 10.35 | 3 | 542677 | 2377 | 63953675 |
Diverticulum intestinal haemorrhagic | 11.32 | 10.35 | 56 | 542624 | 3213 | 63952839 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 11.29 | 10.35 | 36 | 542644 | 1683 | 63954369 |
Blood magnesium decreased | 11.28 | 10.35 | 172 | 542508 | 13733 | 63942319 |
Duodenitis | 11.24 | 10.35 | 96 | 542584 | 6645 | 63949407 |
Pyonephrosis | 11.23 | 10.35 | 8 | 542672 | 87 | 63955965 |
Hepatic steatosis | 11.21 | 10.35 | 341 | 542339 | 30666 | 63925386 |
Renal cyst | 11.19 | 10.35 | 158 | 542522 | 12412 | 63943640 |
Oesophageal adenocarcinoma stage 0 | 11.16 | 10.35 | 4 | 542676 | 7 | 63956045 |
Electrocardiogram QT prolonged | 11.13 | 10.35 | 794 | 541886 | 78654 | 63877398 |
Renal haemorrhage | 11.12 | 10.35 | 39 | 542641 | 1916 | 63954136 |
Gait deviation | 11.10 | 10.35 | 7 | 542673 | 61 | 63955991 |
Actinic keratosis | 11.08 | 10.35 | 78 | 542602 | 5087 | 63950965 |
Carotid endarterectomy | 11.08 | 10.35 | 10 | 542670 | 156 | 63955896 |
Blood pressure diastolic abnormal | 11.08 | 10.35 | 57 | 542623 | 11860 | 63944192 |
Leukaemia recurrent | 11.04 | 10.35 | 4 | 542676 | 2590 | 63953462 |
Idiopathic intracranial hypertension | 11.03 | 10.35 | 4 | 542676 | 2589 | 63953463 |
Bladder cancer | 11.03 | 10.35 | 141 | 542539 | 10833 | 63945219 |
Ventricular arrhythmia | 11.03 | 10.35 | 103 | 542577 | 7312 | 63948740 |
Ear pain | 11.02 | 10.35 | 147 | 542533 | 24989 | 63931063 |
Drug eruption | 11.01 | 10.35 | 226 | 542454 | 35910 | 63920142 |
Renal function test abnormal | 10.99 | 10.35 | 64 | 542616 | 3910 | 63952142 |
Coronary artery embolism | 10.97 | 10.35 | 13 | 542667 | 283 | 63955769 |
Mania | 10.97 | 10.35 | 86 | 542594 | 16200 | 63939852 |
Compartment syndrome | 10.96 | 10.35 | 67 | 542613 | 4165 | 63951887 |
Lipid metabolism disorder | 10.94 | 10.35 | 13 | 542667 | 284 | 63955768 |
Essential tremor | 10.93 | 10.35 | 30 | 542650 | 1289 | 63954763 |
Abnormal behaviour | 10.93 | 10.35 | 208 | 542472 | 33414 | 63922638 |
Systemic mycosis | 10.92 | 10.35 | 3 | 542677 | 2320 | 63953732 |
Hyponatraemic seizure | 10.92 | 10.35 | 17 | 542663 | 484 | 63955568 |
Product prescribing issue | 10.91 | 10.35 | 42 | 542638 | 2159 | 63953893 |
Joint laxity | 10.86 | 10.35 | 3 | 542677 | 2311 | 63953741 |
Renal neoplasm | 10.86 | 10.35 | 35 | 542645 | 1646 | 63954406 |
Overlap syndrome | 10.84 | 10.35 | 21 | 542659 | 715 | 63955337 |
Renovascular hypertension | 10.83 | 10.35 | 6 | 542674 | 40 | 63956012 |
Biopsy colon abnormal | 10.79 | 10.35 | 8 | 542672 | 93 | 63955959 |
Jaundice cholestatic | 10.76 | 10.35 | 116 | 542564 | 8554 | 63947498 |
Anal polyp | 10.74 | 10.35 | 7 | 542673 | 65 | 63955987 |
Ligament sprain | 10.72 | 10.35 | 139 | 542541 | 10713 | 63945339 |
Foot deformity | 10.72 | 10.35 | 88 | 542592 | 16416 | 63939636 |
Osteonecrosis of jaw | 10.72 | 10.35 | 254 | 542426 | 39571 | 63916481 |
Hyperinsulinaemic hypoglycaemia | 10.71 | 10.35 | 9 | 542671 | 127 | 63955925 |
Carotid bruit | 10.69 | 10.35 | 20 | 542660 | 663 | 63955389 |
Diaphragm muscle weakness | 10.68 | 10.35 | 10 | 542670 | 164 | 63955888 |
Infusion site pain | 10.67 | 10.35 | 48 | 542632 | 10349 | 63945703 |
Encephalitis | 10.66 | 10.35 | 62 | 542618 | 12509 | 63943543 |
Pseudohyponatraemia | 10.65 | 10.35 | 9 | 542671 | 128 | 63955924 |
Antimitochondrial antibody positive | 10.65 | 10.35 | 8 | 542672 | 95 | 63955957 |
Circulatory collapse | 10.65 | 10.35 | 365 | 542315 | 33367 | 63922685 |
Prostatic disorder | 10.64 | 10.35 | 35 | 542645 | 1664 | 63954388 |
Transient global amnesia | 10.59 | 10.35 | 20 | 542660 | 668 | 63955384 |
Bronchial secretion retention | 10.58 | 10.35 | 4 | 542676 | 2523 | 63953529 |
Optic discs blurred | 10.56 | 10.35 | 7 | 542673 | 67 | 63955985 |
Amputation | 10.56 | 10.35 | 18 | 542662 | 554 | 63955498 |
Peripheral paralysis | 10.54 | 10.35 | 9 | 542671 | 130 | 63955922 |
IIIrd nerve paresis | 10.53 | 10.35 | 10 | 542670 | 167 | 63955885 |
Rebound tachycardia | 10.51 | 10.35 | 4 | 542676 | 9 | 63956043 |
Paresis | 10.50 | 10.35 | 58 | 542622 | 3474 | 63952578 |
Embedded device | 10.49 | 10.35 | 5 | 542675 | 2747 | 63953305 |
Eye haemorrhage | 10.44 | 10.35 | 112 | 542568 | 8248 | 63947804 |
Blue toe syndrome | 10.42 | 10.35 | 18 | 542662 | 560 | 63955492 |
Hyperaesthesia | 10.42 | 10.35 | 46 | 542634 | 9968 | 63946084 |
Delusion | 10.40 | 10.35 | 99 | 542581 | 17915 | 63938137 |
Cytomegalovirus test positive | 10.40 | 10.35 | 17 | 542663 | 5127 | 63950925 |
Drop attacks | 10.39 | 10.35 | 25 | 542655 | 990 | 63955062 |
Vitreous detachment | 10.39 | 10.35 | 38 | 542642 | 1906 | 63954146 |
Hypertensive angiopathy | 10.38 | 10.35 | 8 | 542672 | 99 | 63955953 |
Interstitial granulomatous dermatitis | 10.37 | 10.35 | 11 | 542669 | 211 | 63955841 |
Penile swelling | 10.35 | 10.35 | 18 | 542662 | 563 | 63955489 |
None
Source | Code | Description |
---|---|---|
ATC | C10AA05 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN HMG CoA reductase inhibitors |
ATC | C10BA05 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BA08 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BX03 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX06 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX08 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX11 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX12 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX15 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX18 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA MoA | N0000000121 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
FDA EPC | N0000175589 | HMG-CoA Reductase Inhibitor |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
MeSH PA | D000924 | Anticholesteremic Agents |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
MeSH PA | D000960 | Hypolipidemic Agents |
MeSH PA | D057847 | Lipid Regulating Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypercholesterolemia | indication | 13644009 | |
Arteriosclerotic vascular disease | indication | 72092001 | |
Prinzmetal angina | indication | 87343002 | |
Angina pectoris | indication | 194828000 | |
Cerebrovascular accident | indication | 230690007 | |
Familial hypercholesterolemia - homozygous | indication | 238078005 | |
Familial hypercholesterolemia - heterozygous | indication | 238079002 | |
Mixed hyperlipidemia | indication | 267434003 | |
Hypertriglyceridemia | indication | 302870006 | |
Familial type 3 hyperlipoproteinemia | indication | 398796005 | DOID:3145 |
Slow Progression of Coronary Artery Disease | indication | ||
Primary Prevention of Coronary Heart Disease | indication | ||
Myocardial Infarction Prevention | indication | ||
Prevention of Transient Ischemic Attacks | off-label use | ||
Alcoholism | contraindication | 7200002 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Low blood pressure | contraindication | 45007003 | |
Hepatic failure | contraindication | 59927004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Liver function tests abnormal | contraindication | 166603001 | |
Hemorrhagic cerebral infarction | contraindication | 230706003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Rhabdomyolysis | contraindication | 240131006 | |
Pregnancy, function | contraindication | 289908002 | |
Surgical procedure | contraindication | 387713003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Traumatic injury | contraindication | 417746004 | |
Severe Aortic Valve Stenosis | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.44 | acidic |
pKa2 | 11.82 | acidic |
pKa3 | 13.63 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | INHIBITOR | IC50 | 8 | WOMBAT-PK | CHEMBL | |||
Cytochrome P450 3A4 | Enzyme | IC50 | 5.29 | CHEMBL | |||||
Histone deacetylase 2 | Enzyme | IC50 | 4.65 | CHEMBL | |||||
Histone deacetylase 1 | Enzyme | IC50 | 4.93 | CHEMBL | |||||
Histone deacetylase 6 | Enzyme | IC50 | 4.84 | CHEMBL | |||||
Nuclear receptor subfamily 1 group I member 3 | Nuclear hormone receptor | WOMBAT-PK | |||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | IC50 | 8.42 | CHEMBL | |||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | IC50 | 4.49 | CHEMBL |
ID | Source |
---|---|
4024041 | VUID |
N0000022046 | NUI |
D00887 | KEGG_DRUG |
134523-03-8 | SECONDARY_CAS_RN |
344423-98-9 | SECONDARY_CAS_RN |
1297766 | RXNORM |
C0286651 | UMLSCUI |
CHEBI:39548 | CHEBI |
117 | PDB_CHEM_ID |
CHEMBL1487 | ChEMBL_ID |
CHEMBL393220 | ChEMBL_ID |
CHEMBL1790017 | ChEMBL_ID |
D000069059 | MESH_DESCRIPTOR_UI |
DB01076 | DRUGBANK_ID |
2949 | IUPHAR_LIGAND_ID |
7259 | INN_ID |
A0JWA85V8F | UNII |
60823 | PUBCHEM_CID |
186242 | MMSL |
34584 | MMSL |
4226 | MMSL |
d04105 | MMSL |
006321 | NDDF |
006322 | NDDF |
4020999 | VANDF |
4024041 | VANDF |
108600003 | SNOMEDCT_US |
108601004 | SNOMEDCT_US |
373444002 | SNOMEDCT_US |
725658002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2150 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2150 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2160 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2160 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2170 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2170 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2180 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2180 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2190 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2190 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2250 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2250 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2260 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2260 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2270 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2270 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2960 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2970 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2980 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-6180 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-6323 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-6565 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-6747 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-7232 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-7476 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-7654 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-7810 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Lipitor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0155 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 29 sections |
Lipitor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0156 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 29 sections |
Lipitor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0157 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 29 sections |