Stem definition | Drug id | CAS RN |
---|---|---|
calcium channel blockers, nifedipine derivatives | 183 | 88150-42-9 |
Dose | Unit | Route |
---|---|---|
5 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.35 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 74 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 17 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 7 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 34 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 31, 1992 | FDA | PFIZER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 976.01 | 9.79 | 3129 | 383758 | 816204 | 49402033 |
Pemphigus | 787.06 | 9.79 | 30 | 386857 | 120136 | 50098101 |
Maternal exposure during pregnancy | 705.97 | 9.79 | 176 | 386711 | 159602 | 50058635 |
Systemic lupus erythematosus | 667.39 | 9.79 | 132 | 386755 | 140490 | 50077747 |
Contraindicated product administered | 652.44 | 9.79 | 167 | 386720 | 148791 | 50069446 |
Completed suicide | 627.12 | 9.79 | 2324 | 384563 | 129565 | 50088672 |
Hand deformity | 580.25 | 9.79 | 50 | 386837 | 100149 | 50118088 |
Glossodynia | 577.50 | 9.79 | 95 | 386792 | 115474 | 50102763 |
Synovitis | 559.69 | 9.79 | 130 | 386757 | 123735 | 50094502 |
Treatment failure | 546.65 | 9.79 | 185 | 386702 | 137452 | 50080785 |
Hypotension | 531.38 | 9.79 | 3346 | 383541 | 232123 | 49986114 |
Anti-cyclic citrullinated peptide antibody positive | 521.45 | 9.79 | 3 | 386884 | 70584 | 50147653 |
Drug intolerance | 498.74 | 9.79 | 564 | 386323 | 218540 | 49999697 |
Infusion related reaction | 482.67 | 9.79 | 355 | 386532 | 169202 | 50049035 |
Pericarditis | 479.08 | 9.79 | 31 | 386856 | 78658 | 50139579 |
Therapeutic product effect decreased | 462.40 | 9.79 | 231 | 386656 | 135819 | 50082418 |
Arthropathy | 445.04 | 9.79 | 334 | 386553 | 157572 | 50060665 |
Off label use | 444.78 | 9.79 | 1992 | 384895 | 472434 | 49745803 |
Hyponatraemia | 422.81 | 9.79 | 1653 | 385234 | 94486 | 50123751 |
Acute kidney injury | 422.43 | 9.79 | 3087 | 383800 | 224971 | 49993266 |
Shock | 413.97 | 9.79 | 640 | 386247 | 20010 | 50198227 |
Alopecia | 408.89 | 9.79 | 783 | 386104 | 244264 | 49973973 |
Blood pressure inadequately controlled | 391.37 | 9.79 | 300 | 386587 | 4080 | 50214157 |
Gingival hypertrophy | 366.19 | 9.79 | 189 | 386698 | 1197 | 50217040 |
Wound | 344.09 | 9.79 | 190 | 386697 | 105604 | 50112633 |
Oedema peripheral | 336.32 | 9.79 | 2213 | 384674 | 155748 | 50062489 |
Rheumatoid arthritis | 330.99 | 9.79 | 655 | 386232 | 201895 | 50016342 |
Non-cardiogenic pulmonary oedema | 326.97 | 9.79 | 134 | 386753 | 447 | 50217790 |
Blood pressure increased | 321.90 | 9.79 | 1927 | 384960 | 131205 | 50087032 |
Rheumatoid factor positive | 308.40 | 9.79 | 18 | 386869 | 49841 | 50168396 |
Exposure during pregnancy | 303.95 | 9.79 | 286 | 386601 | 120729 | 50097508 |
Hepatic enzyme increased | 298.02 | 9.79 | 367 | 386520 | 137013 | 50081224 |
Fall | 297.46 | 9.79 | 3885 | 383002 | 331047 | 49887190 |
Cerebrovascular accident | 286.79 | 9.79 | 1457 | 385430 | 93223 | 50125014 |
Duodenal ulcer perforation | 274.56 | 9.79 | 19 | 386868 | 45592 | 50172645 |
Hypersensitivity | 272.83 | 9.79 | 795 | 386092 | 214366 | 50003871 |
Discomfort | 271.16 | 9.79 | 257 | 386630 | 108123 | 50110114 |
Bradycardia | 268.84 | 9.79 | 1090 | 385797 | 63336 | 50154901 |
Pain | 268.27 | 9.79 | 2984 | 383903 | 575919 | 49642318 |
Orthostatic hypotension | 263.01 | 9.79 | 649 | 386238 | 28832 | 50189405 |
Product use issue | 254.88 | 9.79 | 471 | 386416 | 149004 | 50069233 |
Folliculitis | 249.37 | 9.79 | 12 | 386875 | 39213 | 50179024 |
Helicobacter infection | 230.76 | 9.79 | 49 | 386838 | 49653 | 50168584 |
Abdominal discomfort | 225.80 | 9.79 | 957 | 385930 | 230684 | 49987553 |
Sleep disorder due to general medical condition, insomnia type | 208.73 | 9.79 | 7 | 386880 | 31440 | 50186797 |
Swelling | 205.67 | 9.79 | 814 | 386073 | 200058 | 50018179 |
Dizziness | 200.88 | 9.79 | 3740 | 383147 | 342629 | 49875608 |
Renal impairment | 200.85 | 9.79 | 1123 | 385764 | 74538 | 50143699 |
Vasoplegia syndrome | 198.09 | 9.79 | 117 | 386770 | 997 | 50217240 |
Lactic acidosis | 193.17 | 9.79 | 628 | 386259 | 32727 | 50185510 |
Hyperkalaemia | 193 | 9.79 | 804 | 386083 | 47285 | 50170952 |
C-reactive protein abnormal | 192.77 | 9.79 | 4 | 386883 | 27805 | 50190432 |
Angioedema | 192.35 | 9.79 | 680 | 386207 | 36996 | 50181241 |
Muscle injury | 188.67 | 9.79 | 29 | 386858 | 37082 | 50181155 |
Lower respiratory tract infection | 182.53 | 9.79 | 278 | 386609 | 94923 | 50123314 |
Therapeutic product effect incomplete | 177.62 | 9.79 | 265 | 386622 | 91250 | 50126987 |
Arthralgia | 176.94 | 9.79 | 2329 | 384558 | 436373 | 49781864 |
Abortion spontaneous | 174.89 | 9.79 | 51 | 386836 | 41721 | 50176516 |
Metabolic acidosis | 165.20 | 9.79 | 661 | 386226 | 38164 | 50180073 |
Sinusitis | 164.64 | 9.79 | 707 | 386180 | 169851 | 50048386 |
Infection | 160.85 | 9.79 | 727 | 386160 | 172227 | 50046010 |
Joint swelling | 160.68 | 9.79 | 1156 | 385731 | 244130 | 49974107 |
Impaired healing | 157.03 | 9.79 | 181 | 386706 | 69605 | 50148632 |
Cardiac failure congestive | 155.07 | 9.79 | 1141 | 385746 | 83241 | 50134996 |
Pregnancy | 152.92 | 9.79 | 22 | 386865 | 29555 | 50188682 |
Toxicity to various agents | 150.30 | 9.79 | 2370 | 384517 | 210129 | 50008108 |
Irritable bowel syndrome | 149.73 | 9.79 | 105 | 386782 | 51336 | 50166901 |
Intentional overdose | 149.13 | 9.79 | 902 | 385985 | 61602 | 50156635 |
Hypokalaemia | 146.69 | 9.79 | 1163 | 385724 | 86829 | 50131408 |
Balance disorder | 140.42 | 9.79 | 973 | 385914 | 69617 | 50148620 |
Condition aggravated | 139.05 | 9.79 | 1526 | 385361 | 295532 | 49922705 |
Musculoskeletal stiffness | 136.97 | 9.79 | 512 | 386375 | 127969 | 50090268 |
Device expulsion | 136.72 | 9.79 | 27 | 386860 | 28795 | 50189442 |
Distributive shock | 135.84 | 9.79 | 83 | 386804 | 757 | 50217480 |
Depressed level of consciousness | 135.77 | 9.79 | 768 | 386119 | 51185 | 50167052 |
Creatinine renal clearance decreased | 135.22 | 9.79 | 288 | 386599 | 11593 | 50206644 |
Drug abuse | 132.72 | 9.79 | 157 | 386730 | 59689 | 50158548 |
Hypoglycaemia | 129.58 | 9.79 | 776 | 386111 | 52805 | 50165432 |
Ill-defined disorder | 129.29 | 9.79 | 136 | 386751 | 54518 | 50163719 |
Atrial fibrillation | 128.31 | 9.79 | 1265 | 385622 | 100480 | 50117757 |
Injection site reaction | 127.00 | 9.79 | 117 | 386770 | 49915 | 50168322 |
Blood creatinine increased | 125.50 | 9.79 | 1004 | 385883 | 75156 | 50143081 |
Rash | 123.52 | 9.79 | 2481 | 384406 | 434990 | 49783247 |
Myocardial infarction | 118.21 | 9.79 | 1119 | 385768 | 87908 | 50130329 |
Sedation complication | 115.77 | 9.79 | 226 | 386661 | 8540 | 50209697 |
Injection site erythema | 114.90 | 9.79 | 251 | 386636 | 74685 | 50143552 |
Hypertensive crisis | 113.53 | 9.79 | 286 | 386601 | 12868 | 50205369 |
Neurologic neglect syndrome | 113.33 | 9.79 | 92 | 386795 | 1366 | 50216871 |
Decreased appetite | 110.82 | 9.79 | 2154 | 384733 | 198769 | 50019468 |
Swollen tongue | 103.59 | 9.79 | 464 | 386423 | 28166 | 50190071 |
Injection site pain | 101.17 | 9.79 | 470 | 386417 | 110554 | 50107683 |
Renal failure | 101.05 | 9.79 | 1253 | 385634 | 105380 | 50112857 |
Carotid artery thrombosis | 100.82 | 9.79 | 87 | 386800 | 1412 | 50216825 |
Live birth | 98.26 | 9.79 | 7 | 386880 | 16401 | 50201836 |
Cerebral infarction | 95.26 | 9.79 | 372 | 386515 | 21232 | 50197005 |
Syncope | 94.04 | 9.79 | 1202 | 385685 | 101800 | 50116437 |
Asthenia | 92.62 | 9.79 | 3139 | 383748 | 315903 | 49902334 |
Rhabdomyolysis | 91.67 | 9.79 | 561 | 386326 | 38466 | 50179771 |
Product use in unapproved indication | 91.00 | 9.79 | 516 | 386371 | 115303 | 50102934 |
Anuria | 89.35 | 9.79 | 237 | 386650 | 11007 | 50207230 |
Stomatitis | 88.84 | 9.79 | 435 | 386452 | 100909 | 50117328 |
Intentional product use issue | 87.61 | 9.79 | 298 | 386589 | 76620 | 50141617 |
Gastrointestinal disorder | 86.56 | 9.79 | 399 | 386488 | 94057 | 50124180 |
Atrioventricular block complete | 86.21 | 9.79 | 179 | 386708 | 7076 | 50211161 |
Pyrexia | 84.99 | 9.79 | 2235 | 384652 | 377968 | 49840269 |
Sinus bradycardia | 84.39 | 9.79 | 257 | 386630 | 12926 | 50205311 |
Blood pressure decreased | 84.04 | 9.79 | 722 | 386165 | 55187 | 50163050 |
Drug interaction | 82.04 | 9.79 | 2052 | 384835 | 197569 | 50020668 |
Hypertensive emergency | 80.29 | 9.79 | 78 | 386809 | 1485 | 50216752 |
Dehydration | 79.86 | 9.79 | 1622 | 385265 | 150827 | 50067410 |
Hemiplegia | 79.51 | 9.79 | 175 | 386712 | 7206 | 50211031 |
Coronary artery disease | 79.34 | 9.79 | 442 | 386445 | 29284 | 50188953 |
Blood calcium decreased | 77.49 | 9.79 | 339 | 386548 | 20367 | 50197870 |
Hip arthroplasty | 77.41 | 9.79 | 71 | 386816 | 30358 | 50187879 |
Adjustment disorder | 75.45 | 9.79 | 85 | 386802 | 1934 | 50216303 |
Overdose | 74.48 | 9.79 | 1123 | 385764 | 98604 | 50119633 |
Intentional self-injury | 74.38 | 9.79 | 42 | 386845 | 23070 | 50195167 |
Blood urea increased | 74.17 | 9.79 | 367 | 386520 | 23218 | 50195019 |
Hypertension | 73.89 | 9.79 | 2126 | 384761 | 209077 | 50009160 |
Fibromyalgia | 73.71 | 9.79 | 145 | 386742 | 44833 | 50173404 |
Sprue-like enteropathy | 72.82 | 9.79 | 47 | 386840 | 476 | 50217761 |
Migraine | 72.59 | 9.79 | 312 | 386575 | 74968 | 50143269 |
Subacute cutaneous lupus erythematosus | 72.32 | 9.79 | 87 | 386800 | 2128 | 50216109 |
Circulatory collapse | 72.24 | 9.79 | 324 | 386563 | 19676 | 50198561 |
Cognitive disorder | 71.75 | 9.79 | 580 | 386307 | 43543 | 50174694 |
Chronic kidney disease | 70.30 | 9.79 | 533 | 386354 | 39238 | 50178999 |
Foetal exposure during pregnancy | 69.40 | 9.79 | 64 | 386823 | 27295 | 50190942 |
Cardiac failure | 69.23 | 9.79 | 887 | 386000 | 75153 | 50143084 |
Atrioventricular block first degree | 69.05 | 9.79 | 149 | 386738 | 6052 | 50212185 |
Angina pectoris | 68.97 | 9.79 | 388 | 386499 | 25800 | 50192437 |
Acute myocardial infarction | 68.87 | 9.79 | 421 | 386466 | 28852 | 50189385 |
Renin increased | 67.40 | 9.79 | 30 | 386857 | 129 | 50218108 |
Injection site swelling | 66.46 | 9.79 | 137 | 386750 | 41636 | 50176601 |
Febrile neutropenia | 66.41 | 9.79 | 455 | 386432 | 97212 | 50121025 |
Pulmonary oedema | 66.36 | 9.79 | 618 | 386269 | 48320 | 50169917 |
Palpitations | 64.40 | 9.79 | 1048 | 385839 | 93458 | 50124779 |
Cardiogenic shock | 64.28 | 9.79 | 263 | 386624 | 15336 | 50202901 |
Transient ischaemic attack | 64.03 | 9.79 | 444 | 386443 | 31766 | 50186471 |
Drug level increased | 62.87 | 9.79 | 303 | 386584 | 18965 | 50199272 |
Dyspnoea | 61.65 | 9.79 | 4921 | 381966 | 542687 | 49675550 |
Product prescribing error | 60.90 | 9.79 | 319 | 386568 | 20642 | 50197595 |
Loss of personal independence in daily activities | 59.47 | 9.79 | 304 | 386583 | 69746 | 50148491 |
Psoriatic arthropathy | 59.32 | 9.79 | 174 | 386713 | 46858 | 50171379 |
Injection site pruritus | 57.38 | 9.79 | 141 | 386746 | 40270 | 50177967 |
Hyperglycaemia | 57.28 | 9.79 | 475 | 386412 | 35930 | 50182307 |
Left ventricular hypertrophy | 56.93 | 9.79 | 119 | 386768 | 4726 | 50213511 |
Linear IgA disease | 55.99 | 9.79 | 58 | 386829 | 1196 | 50217041 |
Hypomagnesaemia | 55.73 | 9.79 | 335 | 386552 | 22821 | 50195416 |
Personality disorder | 55.31 | 9.79 | 110 | 386777 | 4214 | 50214023 |
Blister | 54.63 | 9.79 | 405 | 386482 | 85013 | 50133224 |
Anaemia | 53.78 | 9.79 | 2402 | 384485 | 250054 | 49968183 |
Proteinuria | 53.43 | 9.79 | 260 | 386627 | 16337 | 50201900 |
Dysarthria | 53.08 | 9.79 | 477 | 386410 | 36926 | 50181311 |
Blood pressure systolic increased | 52.85 | 9.79 | 457 | 386430 | 34992 | 50183245 |
Rheumatoid nodule | 52.48 | 9.79 | 16 | 386871 | 12719 | 50205518 |
Hepatic function abnormal | 51.19 | 9.79 | 426 | 386461 | 32255 | 50185982 |
Neutropenia | 51.14 | 9.79 | 809 | 386078 | 147156 | 50071081 |
Drug resistance | 51.10 | 9.79 | 42 | 386845 | 18947 | 50199290 |
Knee arthroplasty | 50.95 | 9.79 | 125 | 386762 | 35721 | 50182516 |
Inappropriate antidiuretic hormone secretion | 50.57 | 9.79 | 217 | 386670 | 12926 | 50205311 |
Renal artery stenosis | 50.27 | 9.79 | 63 | 386824 | 1609 | 50216628 |
Oliguria | 49.65 | 9.79 | 157 | 386730 | 8059 | 50210178 |
Schizoaffective disorder | 49.37 | 9.79 | 72 | 386815 | 2134 | 50216103 |
Melaena | 49.16 | 9.79 | 363 | 386524 | 26501 | 50191736 |
Blood potassium decreased | 48.32 | 9.79 | 463 | 386424 | 36482 | 50181755 |
Blood glucose increased | 47.86 | 9.79 | 789 | 386098 | 70535 | 50147702 |
Carotid artery stenosis | 46.32 | 9.79 | 108 | 386779 | 4623 | 50213614 |
Vasodilatation | 46.17 | 9.79 | 71 | 386816 | 2208 | 50216029 |
Atrioventricular block | 45.96 | 9.79 | 131 | 386756 | 6347 | 50211890 |
Tenosynovitis | 45.90 | 9.79 | 12 | 386875 | 10553 | 50207684 |
Sedation | 45.83 | 9.79 | 395 | 386492 | 30215 | 50188022 |
Infective pulmonary exacerbation of cystic fibrosis | 45.61 | 9.79 | 4 | 386883 | 7905 | 50210332 |
Glomerular filtration rate decreased | 45.31 | 9.79 | 193 | 386694 | 11459 | 50206778 |
Foot deformity | 45.20 | 9.79 | 48 | 386839 | 19162 | 50199075 |
Pemphigoid | 44.41 | 9.79 | 122 | 386765 | 5785 | 50212452 |
Haemorrhage subcutaneous | 43.68 | 9.79 | 76 | 386811 | 2625 | 50215612 |
Injection site bruising | 43.54 | 9.79 | 140 | 386747 | 36628 | 50181609 |
Renal disorder | 43.33 | 9.79 | 359 | 386528 | 27146 | 50191091 |
Constipation | 43.11 | 9.79 | 1783 | 385104 | 183925 | 50034312 |
Diabetes mellitus inadequate control | 43.09 | 9.79 | 207 | 386680 | 12938 | 50205299 |
Weight increased | 42.85 | 9.79 | 1195 | 385692 | 200696 | 50017541 |
Suspected suicide | 42.65 | 9.79 | 113 | 386774 | 5244 | 50212993 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 42.43 | 9.79 | 69 | 386818 | 2253 | 50215984 |
Malaise | 42.09 | 9.79 | 3042 | 383845 | 332490 | 49885747 |
Injection site warmth | 42.09 | 9.79 | 27 | 386860 | 13839 | 50204398 |
Nasopharyngitis | 41.70 | 9.79 | 1139 | 385748 | 191788 | 50026449 |
Body temperature increased | 41.70 | 9.79 | 113 | 386774 | 31228 | 50187009 |
Oedema | 41.57 | 9.79 | 761 | 386126 | 69420 | 50148817 |
Fatigue | 40.72 | 9.79 | 4764 | 382123 | 702837 | 49515400 |
Eating disorder | 40.37 | 9.79 | 228 | 386659 | 15181 | 50203056 |
Loss of consciousness | 39.68 | 9.79 | 1062 | 385825 | 103291 | 50114946 |
Premature labour | 39.68 | 9.79 | 19 | 386868 | 11457 | 50206780 |
Drug dependence | 39.50 | 9.79 | 56 | 386831 | 19703 | 50198534 |
Blood creatine phosphokinase increased | 39.34 | 9.79 | 340 | 386547 | 26027 | 50192210 |
Urine output decreased | 39.29 | 9.79 | 171 | 386716 | 10250 | 50207987 |
Caesarean section | 39.17 | 9.79 | 37 | 386850 | 15602 | 50202635 |
Altered state of consciousness | 38.92 | 9.79 | 294 | 386593 | 21616 | 50196621 |
Drug tolerance decreased | 38.67 | 9.79 | 11 | 386876 | 9149 | 50209088 |
Wrong technique in product usage process | 38.52 | 9.79 | 257 | 386630 | 55253 | 50162984 |
Chest pain | 38.07 | 9.79 | 1685 | 385202 | 175197 | 50043040 |
Atrioventricular block second degree | 38.04 | 9.79 | 85 | 386802 | 3536 | 50214701 |
Lip swelling | 37.98 | 9.79 | 321 | 386566 | 24415 | 50193822 |
Urticaria | 37.21 | 9.79 | 732 | 386155 | 128829 | 50089408 |
Glomerulonephritis rapidly progressive | 36.78 | 9.79 | 38 | 386849 | 781 | 50217456 |
Multiple sclerosis relapse | 36.72 | 9.79 | 186 | 386701 | 42778 | 50175459 |
Muscle spasms | 35.97 | 9.79 | 1234 | 385653 | 124319 | 50093918 |
Haematochezia | 35.76 | 9.79 | 464 | 386423 | 39418 | 50178819 |
Gingival swelling | 35.38 | 9.79 | 85 | 386802 | 3710 | 50214527 |
Allergic reaction to excipient | 35.38 | 9.79 | 24 | 386863 | 266 | 50217971 |
Hyperdynamic left ventricle | 35.37 | 9.79 | 19 | 386868 | 132 | 50218105 |
Supraventricular extrasystoles | 35.35 | 9.79 | 87 | 386800 | 3857 | 50214380 |
Gastrointestinal haemorrhage | 34.74 | 9.79 | 769 | 386118 | 72552 | 50145685 |
Premature baby | 34.68 | 9.79 | 54 | 386833 | 18283 | 50199954 |
Abortion induced | 34.63 | 9.79 | 14 | 386873 | 9330 | 50208907 |
Nodal rhythm | 34.37 | 9.79 | 51 | 386836 | 1536 | 50216701 |
Aphasia | 34.30 | 9.79 | 351 | 386536 | 28143 | 50190094 |
Lacunar infarction | 34.17 | 9.79 | 74 | 386813 | 3013 | 50215224 |
Hepatotoxicity | 34.13 | 9.79 | 101 | 386786 | 27125 | 50191112 |
Aortic dissection | 33.98 | 9.79 | 51 | 386836 | 1552 | 50216685 |
Ischaemic stroke | 33.58 | 9.79 | 223 | 386664 | 15725 | 50202512 |
Red blood cell sedimentation rate increased | 33.45 | 9.79 | 114 | 386773 | 29302 | 50188935 |
Device dislocation | 33.15 | 9.79 | 72 | 386815 | 21474 | 50196763 |
Plasma cell myeloma | 33.13 | 9.79 | 376 | 386511 | 30946 | 50187291 |
Drug withdrawal syndrome | 32.94 | 9.79 | 91 | 386796 | 24990 | 50193247 |
Nephrosclerosis | 32.87 | 9.79 | 38 | 386849 | 890 | 50217347 |
Hyperaldosteronism | 32.19 | 9.79 | 21 | 386866 | 217 | 50218020 |
Therapeutic response decreased | 32.11 | 9.79 | 220 | 386667 | 47011 | 50171226 |
Bladder irritation | 32.05 | 9.79 | 20 | 386867 | 190 | 50218047 |
Bundle branch block right | 32.05 | 9.79 | 93 | 386794 | 4552 | 50213685 |
Gingival bleeding | 31.76 | 9.79 | 171 | 386716 | 11182 | 50207055 |
Injury | 31.74 | 9.79 | 231 | 386656 | 48694 | 50169543 |
Swelling face | 31.38 | 9.79 | 571 | 386316 | 52024 | 50166213 |
Metastases to bone | 31.25 | 9.79 | 56 | 386831 | 17939 | 50200298 |
Ear pain | 31.23 | 9.79 | 111 | 386776 | 28172 | 50190065 |
Motor dysfunction | 31.21 | 9.79 | 133 | 386754 | 7898 | 50210339 |
Affect lability | 31.18 | 9.79 | 144 | 386743 | 8854 | 50209383 |
Respiratory failure | 31.04 | 9.79 | 915 | 385972 | 90266 | 50127971 |
Leukopenia | 30.65 | 9.79 | 349 | 386538 | 67179 | 50151058 |
Pulmonary renal syndrome | 30.59 | 9.79 | 25 | 386862 | 375 | 50217862 |
Fear of injection | 30.49 | 9.79 | 5 | 386882 | 6098 | 50212139 |
Dyspnoea exertional | 30.49 | 9.79 | 556 | 386331 | 50677 | 50167560 |
Intestinal malrotation | 29.98 | 9.79 | 24 | 386863 | 349 | 50217888 |
Haematemesis | 29.86 | 9.79 | 334 | 386553 | 27391 | 50190846 |
Septic shock | 29.82 | 9.79 | 286 | 386601 | 56889 | 50161348 |
Enthesopathy | 29.71 | 9.79 | 9 | 386878 | 7184 | 50211053 |
Blood potassium increased | 29.67 | 9.79 | 221 | 386666 | 16177 | 50202060 |
Immunodeficiency | 29.67 | 9.79 | 42 | 386845 | 14786 | 50203451 |
BRASH syndrome | 29.31 | 9.79 | 19 | 386868 | 194 | 50218043 |
Suicide attempt | 28.92 | 9.79 | 556 | 386331 | 51176 | 50167061 |
Hyperuricaemia | 28.80 | 9.79 | 90 | 386797 | 4590 | 50213647 |
Ear infection | 28.62 | 9.79 | 102 | 386785 | 25868 | 50192369 |
Angina unstable | 28.37 | 9.79 | 114 | 386773 | 6592 | 50211645 |
Pollakiuria | 28.32 | 9.79 | 293 | 386594 | 23558 | 50194679 |
Arrhythmia | 28.26 | 9.79 | 382 | 386505 | 32750 | 50185487 |
Injection site urticaria | 28.22 | 9.79 | 31 | 386856 | 12186 | 50206051 |
Lung diffusion test abnormal | 28.10 | 9.79 | 17 | 386870 | 152 | 50218085 |
Product substitution issue | 28.07 | 9.79 | 194 | 386693 | 13863 | 50204374 |
Myocardial ischaemia | 27.94 | 9.79 | 168 | 386719 | 11445 | 50206792 |
Sinus arrest | 27.75 | 9.79 | 48 | 386839 | 1650 | 50216587 |
Disorientation | 27.41 | 9.79 | 402 | 386485 | 35082 | 50183155 |
Stillbirth | 27.35 | 9.79 | 6 | 386881 | 5946 | 50212291 |
Unintended pregnancy | 27.21 | 9.79 | 3 | 386884 | 4943 | 50213294 |
Product label on wrong product | 27.17 | 9.79 | 7 | 386880 | 0 | 50218237 |
Product monitoring error | 26.95 | 9.79 | 63 | 386824 | 2701 | 50215536 |
Premature delivery | 26.71 | 9.79 | 92 | 386795 | 23571 | 50194666 |
Feeling abnormal | 26.66 | 9.79 | 1194 | 385693 | 124298 | 50093939 |
Parkinsonism | 26.64 | 9.79 | 136 | 386751 | 8711 | 50209526 |
Hypocalcaemia | 26.62 | 9.79 | 318 | 386569 | 26498 | 50191739 |
Hemiparesis | 26.58 | 9.79 | 252 | 386635 | 19796 | 50198441 |
Panniculitis | 26.58 | 9.79 | 16 | 386871 | 8487 | 50209750 |
Uterine perforation | 26.54 | 9.79 | 8 | 386879 | 6407 | 50211830 |
Hypervolaemia | 26.48 | 9.79 | 305 | 386582 | 25194 | 50193043 |
Accidental exposure to product | 26.46 | 9.79 | 89 | 386798 | 22968 | 50195269 |
Sensory loss | 26.20 | 9.79 | 123 | 386764 | 7615 | 50210622 |
Myocardial depression | 26.06 | 9.79 | 24 | 386863 | 426 | 50217811 |
Unintentional medical device removal | 25.97 | 9.79 | 5 | 386882 | 5430 | 50212807 |
Haematotoxicity | 25.90 | 9.79 | 14 | 386873 | 7881 | 50210356 |
Ischaemia | 25.86 | 9.79 | 82 | 386805 | 4215 | 50214022 |
Nocturia | 25.80 | 9.79 | 111 | 386776 | 6619 | 50211618 |
Ovarian cyst | 25.73 | 9.79 | 42 | 386845 | 13954 | 50204283 |
Ageusia | 25.63 | 9.79 | 164 | 386723 | 11419 | 50206818 |
Confusional state | 25.59 | 9.79 | 1699 | 385188 | 184229 | 50034008 |
Bone erosion | 25.54 | 9.79 | 31 | 386856 | 11656 | 50206581 |
Faeces discoloured | 25.15 | 9.79 | 210 | 386677 | 15914 | 50202323 |
Myalgia | 25.15 | 9.79 | 1177 | 385710 | 123142 | 50095095 |
Labile hypertension | 25.13 | 9.79 | 24 | 386863 | 447 | 50217790 |
Gangrene | 25.07 | 9.79 | 86 | 386801 | 4606 | 50213631 |
Listless | 24.99 | 9.79 | 56 | 386831 | 2334 | 50215903 |
Arteriosclerosis | 24.91 | 9.79 | 136 | 386751 | 8941 | 50209296 |
Generalised oedema | 24.81 | 9.79 | 185 | 386702 | 13546 | 50204691 |
Hyperlipidaemia | 24.78 | 9.79 | 223 | 386664 | 17267 | 50200970 |
Gastric ulcer haemorrhage | 24.68 | 9.79 | 83 | 386804 | 4401 | 50213836 |
Glycosylated haemoglobin increased | 24.61 | 9.79 | 152 | 386735 | 10454 | 50207783 |
Type 2 diabetes mellitus | 24.43 | 9.79 | 158 | 386729 | 34217 | 50184020 |
Aortic aneurysm | 24.38 | 9.79 | 67 | 386820 | 3178 | 50215059 |
Scleral discolouration | 24.33 | 9.79 | 21 | 386866 | 341 | 50217896 |
Loose tooth | 24.31 | 9.79 | 67 | 386820 | 3183 | 50215054 |
Pathogen resistance | 23.71 | 9.79 | 7 | 386880 | 5682 | 50212555 |
Mental status changes | 23.50 | 9.79 | 399 | 386488 | 35873 | 50182364 |
Dysphagia | 23.49 | 9.79 | 767 | 386120 | 76751 | 50141486 |
Fibromuscular dysplasia | 23.24 | 9.79 | 16 | 386871 | 182 | 50218055 |
Blood pressure abnormal | 23.18 | 9.79 | 172 | 386715 | 12575 | 50205662 |
Heavy menstrual bleeding | 23.02 | 9.79 | 53 | 386834 | 15484 | 50202753 |
C-reactive protein increased | 22.76 | 9.79 | 364 | 386523 | 66110 | 50152127 |
Pleural effusion | 22.67 | 9.79 | 798 | 386089 | 80656 | 50137581 |
Tubulointerstitial nephritis | 22.62 | 9.79 | 196 | 386691 | 15015 | 50203222 |
Neovascularisation | 22.58 | 9.79 | 33 | 386854 | 980 | 50217257 |
Hypoglycaemic coma | 22.56 | 9.79 | 53 | 386834 | 2280 | 50215957 |
Conjoined twins | 22.47 | 9.79 | 18 | 386869 | 262 | 50217975 |
Hepatocellular carcinoma | 22.22 | 9.79 | 48 | 386839 | 1951 | 50216286 |
Joint effusion | 22.18 | 9.79 | 41 | 386846 | 12980 | 50205257 |
Acute coronary syndrome | 22.16 | 9.79 | 135 | 386752 | 9239 | 50208998 |
Foetal death | 22.12 | 9.79 | 18 | 386869 | 8162 | 50210075 |
Subdural haematoma | 22.03 | 9.79 | 172 | 386715 | 12775 | 50205462 |
Acute motor-sensory axonal neuropathy | 22.02 | 9.79 | 18 | 386869 | 270 | 50217967 |
Tongue oedema | 21.96 | 9.79 | 72 | 386815 | 3767 | 50214470 |
Psychotic disorder | 21.88 | 9.79 | 89 | 386798 | 21723 | 50196514 |
Lymphocyte stimulation test positive | 21.87 | 9.79 | 23 | 386864 | 483 | 50217754 |
Device difficult to use | 21.84 | 9.79 | 26 | 386861 | 9860 | 50208377 |
Cholecystitis chronic | 21.82 | 9.79 | 25 | 386862 | 9644 | 50208593 |
Injection site rash | 21.76 | 9.79 | 58 | 386829 | 16119 | 50202118 |
Harlequin syndrome | 21.53 | 9.79 | 9 | 386878 | 32 | 50218205 |
Haemoglobin decreased | 21.53 | 9.79 | 1184 | 385703 | 126032 | 50092205 |
Prescription drug used without a prescription | 21.45 | 9.79 | 43 | 386844 | 1657 | 50216580 |
Haemodialysis | 21.43 | 9.79 | 123 | 386764 | 8239 | 50209998 |
Inflammation | 21.41 | 9.79 | 306 | 386581 | 56606 | 50161631 |
Lichen nitidus | 21.40 | 9.79 | 11 | 386876 | 69 | 50218168 |
Atrioventricular dissociation | 21.34 | 9.79 | 16 | 386871 | 210 | 50218027 |
Nephrogenic systemic fibrosis | 21.19 | 9.79 | 77 | 386810 | 4245 | 50213992 |
Therapy partial responder | 21.17 | 9.79 | 12 | 386875 | 6579 | 50211658 |
Disability | 21.08 | 9.79 | 41 | 386846 | 12734 | 50205503 |
Hypoperfusion | 20.96 | 9.79 | 37 | 386850 | 1293 | 50216944 |
Tendonitis | 20.91 | 9.79 | 62 | 386825 | 16643 | 50201594 |
Diabetic nephropathy | 20.78 | 9.79 | 37 | 386850 | 1302 | 50216935 |
Blood aldosterone increased | 20.65 | 9.79 | 14 | 386873 | 155 | 50218082 |
Dysgeusia | 20.65 | 9.79 | 415 | 386472 | 38501 | 50179736 |
Chronic pigmented purpura | 20.65 | 9.79 | 11 | 386876 | 75 | 50218162 |
Diarrhoea | 20.63 | 9.79 | 4934 | 381953 | 583542 | 49634695 |
Medication error | 20.50 | 9.79 | 389 | 386498 | 35715 | 50182522 |
Hyperkaliuria | 20.37 | 9.79 | 10 | 386877 | 56 | 50218181 |
Blood glucose decreased | 20.35 | 9.79 | 221 | 386666 | 17990 | 50200247 |
Hypernatraemia | 20.33 | 9.79 | 99 | 386788 | 6222 | 50212015 |
Hypertensive heart disease | 20.26 | 9.79 | 50 | 386837 | 2220 | 50216017 |
Autoimmune enteropathy | 20.25 | 9.79 | 6 | 386881 | 4 | 50218233 |
Electrocardiogram abnormal | 20.23 | 9.79 | 113 | 386774 | 7492 | 50210745 |
Anaphylactic reaction | 20.21 | 9.79 | 291 | 386596 | 53764 | 50164473 |
Venoocclusive liver disease | 20.19 | 9.79 | 4 | 386883 | 4257 | 50213980 |
Dementia | 20.19 | 9.79 | 199 | 386688 | 15798 | 50202439 |
Gingival atrophy | 20.14 | 9.79 | 8 | 386879 | 24 | 50218213 |
Retinal ischaemia | 20.13 | 9.79 | 18 | 386869 | 307 | 50217930 |
Grip strength decreased | 19.92 | 9.79 | 39 | 386848 | 12082 | 50206155 |
Gingivitis | 19.89 | 9.79 | 109 | 386778 | 7175 | 50211062 |
Device adhesion issue | 19.83 | 9.79 | 3 | 386884 | 3882 | 50214355 |
Irritability | 19.52 | 9.79 | 132 | 386755 | 28294 | 50189943 |
Gestational diabetes | 19.49 | 9.79 | 17 | 386870 | 7448 | 50210789 |
Lymphocele | 19.42 | 9.79 | 27 | 386860 | 765 | 50217472 |
Urine albumin/creatinine ratio increased | 19.38 | 9.79 | 15 | 386872 | 207 | 50218030 |
Hypoglossal nerve paralysis | 19.27 | 9.79 | 7 | 386880 | 15 | 50218222 |
Skin tightness | 19.27 | 9.79 | 68 | 386819 | 3695 | 50214542 |
Mucosal inflammation | 19.19 | 9.79 | 205 | 386682 | 39937 | 50178300 |
Hypertensive encephalopathy | 19.17 | 9.79 | 23 | 386864 | 561 | 50217676 |
Bone marrow failure | 19.11 | 9.79 | 128 | 386759 | 27496 | 50190741 |
Ankylosing spondylitis | 19.09 | 9.79 | 16 | 386871 | 7149 | 50211088 |
Sinus rhythm | 19.06 | 9.79 | 24 | 386863 | 616 | 50217621 |
Acute hepatic failure | 19.04 | 9.79 | 59 | 386828 | 15618 | 50202619 |
Hypothermia | 19.01 | 9.79 | 157 | 386730 | 11859 | 50206378 |
Upper respiratory tract infection | 19.00 | 9.79 | 372 | 386515 | 65526 | 50152711 |
Pseudolymphoma | 18.98 | 9.79 | 23 | 386864 | 567 | 50217670 |
Heart rate decreased | 18.97 | 9.79 | 388 | 386499 | 36109 | 50182128 |
Periodontitis | 18.87 | 9.79 | 59 | 386828 | 3010 | 50215227 |
Gallbladder adenocarcinoma | 18.79 | 9.79 | 11 | 386876 | 92 | 50218145 |
Purpura | 18.75 | 9.79 | 135 | 386752 | 9776 | 50208461 |
Oral discharge | 18.73 | 9.79 | 13 | 386874 | 150 | 50218087 |
Haemodynamic instability | 18.62 | 9.79 | 115 | 386772 | 7909 | 50210328 |
Upper gastrointestinal haemorrhage | 18.57 | 9.79 | 196 | 386691 | 15839 | 50202398 |
Reduced facial expression | 18.55 | 9.79 | 39 | 386848 | 1555 | 50216682 |
Blood uric acid increased | 18.54 | 9.79 | 68 | 386819 | 3766 | 50214471 |
Mydriasis | 18.52 | 9.79 | 33 | 386854 | 10594 | 50207643 |
Skin candida | 18.51 | 9.79 | 35 | 386852 | 1291 | 50216946 |
Device issue | 18.50 | 9.79 | 84 | 386803 | 19888 | 50198349 |
Blood lactic acid increased | 18.34 | 9.79 | 88 | 386799 | 5497 | 50212740 |
Staphylococcal infection | 18.22 | 9.79 | 179 | 386708 | 35437 | 50182800 |
Febrile bone marrow aplasia | 18.20 | 9.79 | 13 | 386874 | 6298 | 50211939 |
Sickle cell anaemia with crisis | 18.20 | 9.79 | 6 | 386881 | 4537 | 50213700 |
Acute myeloid leukaemia | 18.12 | 9.79 | 57 | 386830 | 15017 | 50203220 |
Seizure | 18.07 | 9.79 | 727 | 386160 | 117147 | 50101090 |
Rectourethral fistula | 18.05 | 9.79 | 8 | 386879 | 34 | 50218203 |
Colitis ulcerative | 18.04 | 9.79 | 67 | 386820 | 16787 | 50201450 |
Mood swings | 18.02 | 9.79 | 62 | 386825 | 15892 | 50202345 |
Blood cholesterol increased | 18.02 | 9.79 | 305 | 386582 | 54910 | 50163327 |
Head discomfort | 17.99 | 9.79 | 145 | 386742 | 10874 | 50207363 |
Drug hypersensitivity | 17.98 | 9.79 | 1663 | 385224 | 249347 | 49968890 |
Vision blurred | 17.97 | 9.79 | 754 | 386133 | 77893 | 50140344 |
Cardiac disorder | 17.96 | 9.79 | 443 | 386444 | 42536 | 50175701 |
Rectal ulcer haemorrhage | 17.90 | 9.79 | 13 | 386874 | 162 | 50218075 |
Pericardial effusion | 17.87 | 9.79 | 285 | 386602 | 25304 | 50192933 |
Blood loss anaemia | 17.86 | 9.79 | 115 | 386772 | 8024 | 50210213 |
Protein urine present | 17.86 | 9.79 | 85 | 386802 | 5292 | 50212945 |
Adenoma benign | 17.64 | 9.79 | 26 | 386861 | 778 | 50217459 |
Blood parathyroid hormone decreased | 17.62 | 9.79 | 17 | 386870 | 7097 | 50211140 |
Abnormal loss of weight | 17.51 | 9.79 | 81 | 386806 | 4983 | 50213254 |
Restlessness | 17.45 | 9.79 | 280 | 386607 | 24893 | 50193344 |
Congenital bladder anomaly | 17.32 | 9.79 | 13 | 386874 | 171 | 50218066 |
Body tinea | 17.26 | 9.79 | 34 | 386853 | 1293 | 50216944 |
Presyncope | 17.09 | 9.79 | 270 | 386617 | 23928 | 50194309 |
Product storage error | 17.08 | 9.79 | 43 | 386844 | 12181 | 50206056 |
Cardiac failure chronic | 17.06 | 9.79 | 63 | 386824 | 3500 | 50214737 |
Fryns syndrome | 17.06 | 9.79 | 9 | 386878 | 60 | 50218177 |
Vitello-intestinal duct remnant | 17.02 | 9.79 | 8 | 386879 | 40 | 50218197 |
Putamen haemorrhage | 17.01 | 9.79 | 13 | 386874 | 176 | 50218061 |
Urachal abnormality | 16.82 | 9.79 | 13 | 386874 | 179 | 50218058 |
Anorexia nervosa | 16.82 | 9.79 | 13 | 386874 | 179 | 50218058 |
Lethargy | 16.80 | 9.79 | 496 | 386391 | 48936 | 50169301 |
Nephrogenic anaemia | 16.78 | 9.79 | 39 | 386848 | 1666 | 50216571 |
Adverse drug reaction | 16.76 | 9.79 | 309 | 386578 | 54913 | 50163324 |
Granuloma skin | 16.76 | 9.79 | 12 | 386875 | 5806 | 50212431 |
Premature rupture of membranes | 16.75 | 9.79 | 7 | 386880 | 4573 | 50213664 |
Lymphocyte count decreased | 16.68 | 9.79 | 125 | 386762 | 26182 | 50192055 |
Nodule | 16.67 | 9.79 | 70 | 386817 | 16933 | 50201304 |
Bursitis | 16.63 | 9.79 | 100 | 386787 | 22035 | 50196202 |
Status epilepticus | 16.61 | 9.79 | 50 | 386837 | 13356 | 50204881 |
Gravitational oedema | 16.57 | 9.79 | 31 | 386856 | 1134 | 50217103 |
Urinary retention | 16.57 | 9.79 | 287 | 386600 | 25903 | 50192334 |
Transcription medication error | 16.53 | 9.79 | 13 | 386874 | 184 | 50218053 |
Benign neoplasm of adrenal gland | 16.51 | 9.79 | 7 | 386880 | 26 | 50218211 |
Peripheral arterial occlusive disease | 16.49 | 9.79 | 62 | 386825 | 3475 | 50214762 |
Gingival pain | 16.49 | 9.79 | 90 | 386797 | 5916 | 50212321 |
Albuminuria | 16.41 | 9.79 | 13 | 386874 | 186 | 50218051 |
Ventricular failure | 16.39 | 9.79 | 17 | 386870 | 351 | 50217886 |
Cytomegalovirus infection | 16.37 | 9.79 | 76 | 386811 | 17886 | 50200351 |
Myelosuppression | 16.33 | 9.79 | 51 | 386836 | 13466 | 50204771 |
Coordination abnormal | 16.31 | 9.79 | 147 | 386740 | 11387 | 50206850 |
Skin discolouration | 16.29 | 9.79 | 346 | 386541 | 32411 | 50185826 |
Cardiac arrest | 16.28 | 9.79 | 789 | 386098 | 82862 | 50135375 |
Injection site haemorrhage | 16.26 | 9.79 | 96 | 386791 | 21250 | 50196987 |
Cerebral haemorrhage | 16.24 | 9.79 | 294 | 386593 | 26758 | 50191479 |
Cardiomegaly | 16.23 | 9.79 | 190 | 386697 | 15755 | 50202482 |
Organ failure | 16.19 | 9.79 | 47 | 386840 | 2301 | 50215936 |
Neurotoxicity | 16.17 | 9.79 | 58 | 386829 | 14682 | 50203555 |
Insulin-like growth factor decreased | 16.16 | 9.79 | 17 | 386870 | 357 | 50217880 |
Skin induration | 16.12 | 9.79 | 54 | 386833 | 2857 | 50215380 |
Osteopenia | 16.11 | 9.79 | 71 | 386816 | 16947 | 50201290 |
Blood sodium decreased | 16.10 | 9.79 | 239 | 386648 | 20908 | 50197329 |
Skin weeping | 16.10 | 9.79 | 18 | 386869 | 406 | 50217831 |
Suspected product quality issue | 16.07 | 9.79 | 13 | 386874 | 192 | 50218045 |
Persistent cloaca | 16.07 | 9.79 | 13 | 386874 | 192 | 50218045 |
Vertigo | 15.99 | 9.79 | 514 | 386373 | 51318 | 50166919 |
Mitral valve incompetence | 15.97 | 9.79 | 204 | 386683 | 17267 | 50200970 |
Hypergastrinaemia | 15.94 | 9.79 | 10 | 386877 | 96 | 50218141 |
Saliva discolouration | 15.93 | 9.79 | 7 | 386880 | 29 | 50218208 |
Cerebral ischaemia | 15.86 | 9.79 | 88 | 386799 | 5820 | 50212417 |
Cough | 15.86 | 9.79 | 2091 | 384796 | 239173 | 49979064 |
Dialysis | 15.85 | 9.79 | 125 | 386762 | 9313 | 50208924 |
Pulse abnormal | 15.80 | 9.79 | 40 | 386847 | 1805 | 50216432 |
Gastrointestinal toxicity | 15.78 | 9.79 | 8 | 386879 | 4669 | 50213568 |
Generalised tonic-clonic seizure | 15.75 | 9.79 | 127 | 386760 | 26183 | 50192054 |
Humerus fracture | 15.72 | 9.79 | 106 | 386781 | 7512 | 50210725 |
Congenital acrochordon | 15.72 | 9.79 | 8 | 386879 | 49 | 50218188 |
Renal cell carcinoma | 15.68 | 9.79 | 56 | 386831 | 3061 | 50215176 |
Haemorrhage intracranial | 15.65 | 9.79 | 154 | 386733 | 12220 | 50206017 |
Fluid intake reduced | 15.63 | 9.79 | 56 | 386831 | 3066 | 50215171 |
Osteoporosis | 15.61 | 9.79 | 245 | 386642 | 44634 | 50173603 |
Substance abuse | 15.58 | 9.79 | 6 | 386881 | 4118 | 50214119 |
CD30 expression | 15.57 | 9.79 | 7 | 386880 | 31 | 50218206 |
Adverse event | 15.53 | 9.79 | 238 | 386649 | 43525 | 50174712 |
Peritoneal effluent leukocyte count increased | 15.53 | 9.79 | 4 | 386883 | 0 | 50218237 |
Complication of device insertion | 15.48 | 9.79 | 14 | 386873 | 6027 | 50212210 |
Metabolic alkalosis | 15.43 | 9.79 | 51 | 386836 | 2680 | 50215557 |
Tachypnoea | 15.42 | 9.79 | 175 | 386712 | 14402 | 50203835 |
Blood cholinesterase decreased | 15.35 | 9.79 | 10 | 386877 | 103 | 50218134 |
Carotid arteriosclerosis | 15.29 | 9.79 | 27 | 386860 | 944 | 50217293 |
Full blood count decreased | 15.28 | 9.79 | 248 | 386639 | 22098 | 50196139 |
Maternal drugs affecting foetus | 15.25 | 9.79 | 10 | 386877 | 5067 | 50213170 |
Device deployment issue | 15.13 | 9.79 | 4 | 386883 | 3492 | 50214745 |
Coeliac disease | 15.11 | 9.79 | 27 | 386860 | 8658 | 50209579 |
Infected dermal cyst | 15.10 | 9.79 | 18 | 386869 | 436 | 50217801 |
Jaundice | 15.09 | 9.79 | 285 | 386602 | 26144 | 50192093 |
Ventricular septal defect | 15.06 | 9.79 | 6 | 386881 | 4035 | 50214202 |
Zinc deficiency | 15.06 | 9.79 | 7 | 386880 | 34 | 50218203 |
Taste disorder | 14.95 | 9.79 | 112 | 386775 | 8212 | 50210025 |
Dermatitis bullous | 14.92 | 9.79 | 100 | 386787 | 7073 | 50211164 |
Neurosensory hypoacusis | 14.91 | 9.79 | 13 | 386874 | 214 | 50218023 |
Dysphoria | 14.90 | 9.79 | 9 | 386878 | 4765 | 50213472 |
Hypertensive angiopathy | 14.83 | 9.79 | 9 | 386878 | 81 | 50218156 |
Hyperplastic cholecystopathy | 14.83 | 9.79 | 9 | 386878 | 81 | 50218156 |
Joint stiffness | 14.80 | 9.79 | 154 | 386733 | 30154 | 50188083 |
Oropharyngeal swelling | 14.79 | 9.79 | 24 | 386863 | 782 | 50217455 |
Finger deformity | 14.76 | 9.79 | 13 | 386874 | 5669 | 50212568 |
Schizophrenia | 14.75 | 9.79 | 21 | 386866 | 7376 | 50210861 |
Apical granuloma | 14.74 | 9.79 | 7 | 386880 | 36 | 50218201 |
Inhibitory drug interaction | 14.73 | 9.79 | 44 | 386843 | 2189 | 50216048 |
Exercise tolerance decreased | 14.73 | 9.79 | 75 | 386812 | 4799 | 50213438 |
Kidney transplant rejection | 14.71 | 9.79 | 65 | 386822 | 3922 | 50214315 |
Acute respiratory failure | 14.63 | 9.79 | 305 | 386582 | 28477 | 50189760 |
Temperature regulation disorder | 14.61 | 9.79 | 7 | 386880 | 4220 | 50214017 |
Forced vital capacity decreased | 14.60 | 9.79 | 26 | 386861 | 915 | 50217322 |
Product solubility abnormal | 14.59 | 9.79 | 23 | 386864 | 731 | 50217506 |
Sleep disorder | 14.57 | 9.79 | 330 | 386557 | 56953 | 50161284 |
Electrocardiogram U wave present | 14.56 | 9.79 | 9 | 386878 | 84 | 50218153 |
Joint injury | 14.56 | 9.79 | 102 | 386785 | 21687 | 50196550 |
Arterial occlusive disease | 14.54 | 9.79 | 74 | 386813 | 4734 | 50213503 |
Soft tissue disorder | 14.53 | 9.79 | 7 | 386880 | 4207 | 50214030 |
Post transplant lymphoproliferative disorder | 14.47 | 9.79 | 7 | 386880 | 4197 | 50214040 |
Renal transplant | 14.39 | 9.79 | 30 | 386857 | 1189 | 50217048 |
Vasculitis | 14.37 | 9.79 | 167 | 386720 | 13824 | 50204413 |
Ventricular extrasystoles | 14.35 | 9.79 | 133 | 386754 | 10383 | 50207854 |
Oxalosis | 14.29 | 9.79 | 7 | 386880 | 39 | 50218198 |
Hyperprolactinaemia | 14.28 | 9.79 | 4 | 386883 | 3361 | 50214876 |
Norepinephrine increased | 14.28 | 9.79 | 8 | 386879 | 61 | 50218176 |
Chondroma | 14.21 | 9.79 | 6 | 386881 | 22 | 50218215 |
Pancreatic toxicity | 14.21 | 9.79 | 6 | 386881 | 22 | 50218215 |
Amenorrhoea | 14.20 | 9.79 | 27 | 386860 | 8457 | 50209780 |
Kidney fibrosis | 14.19 | 9.79 | 35 | 386852 | 1554 | 50216683 |
Thirst | 14.18 | 9.79 | 134 | 386753 | 10516 | 50207721 |
Crush syndrome | 14.15 | 9.79 | 10 | 386877 | 119 | 50218118 |
Gout | 14.14 | 9.79 | 142 | 386745 | 11328 | 50206909 |
Renal tubular necrosis | 14.08 | 9.79 | 129 | 386758 | 10039 | 50208198 |
Labelled drug-drug interaction medication error | 14.04 | 9.79 | 132 | 386755 | 10345 | 50207892 |
Cytokine release syndrome | 14.00 | 9.79 | 28 | 386859 | 8606 | 50209631 |
Congenital nail disorder | 13.96 | 9.79 | 9 | 386878 | 91 | 50218146 |
Multiple-drug resistance | 13.95 | 9.79 | 4 | 386883 | 3310 | 50214927 |
Intestinal ischaemia | 13.93 | 9.79 | 94 | 386793 | 6663 | 50211574 |
Hallucination, gustatory | 13.86 | 9.79 | 8 | 386879 | 65 | 50218172 |
Skin necrosis | 13.85 | 9.79 | 40 | 386847 | 10827 | 50207410 |
Dermatosis | 13.84 | 9.79 | 13 | 386874 | 237 | 50218000 |
Dyslalia | 13.78 | 9.79 | 17 | 386870 | 427 | 50217810 |
Genital haemorrhage | 13.78 | 9.79 | 18 | 386869 | 6556 | 50211681 |
Prescribed overdose | 13.77 | 9.79 | 61 | 386826 | 14539 | 50203698 |
Microalbuminuria | 13.71 | 9.79 | 15 | 386872 | 330 | 50217907 |
Dystonia | 13.71 | 9.79 | 46 | 386841 | 11880 | 50206357 |
Burn oesophageal | 13.68 | 9.79 | 11 | 386876 | 161 | 50218076 |
Platelet aggregation decreased | 13.63 | 9.79 | 6 | 386881 | 25 | 50218212 |
Rib deformity | 13.62 | 9.79 | 11 | 386876 | 162 | 50218075 |
Cerebrovascular disorder | 13.56 | 9.79 | 47 | 386840 | 2531 | 50215706 |
Deformity | 13.53 | 9.79 | 25 | 386862 | 7915 | 50210322 |
Electrolyte imbalance | 13.45 | 9.79 | 195 | 386692 | 16974 | 50201263 |
Hyperparathyroidism secondary | 13.42 | 9.79 | 31 | 386856 | 1319 | 50216918 |
Dermatitis exfoliative | 13.41 | 9.79 | 76 | 386811 | 5066 | 50213171 |
Diverticulum intestinal haemorrhagic | 13.39 | 9.79 | 29 | 386858 | 1181 | 50217056 |
Hypomania | 13.36 | 9.79 | 9 | 386878 | 4496 | 50213741 |
Intestinal villi atrophy | 13.30 | 9.79 | 11 | 386876 | 168 | 50218069 |
Suicidal ideation | 13.27 | 9.79 | 322 | 386565 | 55063 | 50163174 |
Bradyarrhythmia | 13.19 | 9.79 | 38 | 386849 | 1852 | 50216385 |
Device malfunction | 13.18 | 9.79 | 65 | 386822 | 15056 | 50203181 |
Essential hypertension | 13.16 | 9.79 | 68 | 386819 | 4376 | 50213861 |
Sinus arrhythmia | 13.13 | 9.79 | 31 | 386856 | 1338 | 50216899 |
Stomatitis haemorrhagic | 13.09 | 9.79 | 6 | 386881 | 28 | 50218209 |
Lichen planus | 13.06 | 9.79 | 39 | 386848 | 1940 | 50216297 |
Macular degeneration | 13.04 | 9.79 | 61 | 386826 | 14327 | 50203910 |
Capillary disorder | 13.00 | 9.79 | 8 | 386879 | 74 | 50218163 |
Skin haemorrhage | 12.95 | 9.79 | 94 | 386793 | 6824 | 50211413 |
Cystic fibrosis | 12.93 | 9.79 | 3 | 386884 | 2861 | 50215376 |
Toxic epidermal necrolysis | 12.90 | 9.79 | 229 | 386658 | 20763 | 50197474 |
Ischaemic cardiomyopathy | 12.90 | 9.79 | 43 | 386844 | 2269 | 50215968 |
Retroperitoneal haematoma | 12.88 | 9.79 | 47 | 386840 | 2596 | 50215641 |
Interstitial lung disease | 12.88 | 9.79 | 513 | 386374 | 52663 | 50165574 |
Cell marker increased | 12.87 | 9.79 | 13 | 386874 | 260 | 50217977 |
Pigmentation disorder | 12.87 | 9.79 | 60 | 386827 | 3704 | 50214533 |
Atrial pressure increased | 12.84 | 9.79 | 5 | 386882 | 14 | 50218223 |
No adverse event | 12.82 | 9.79 | 180 | 386707 | 33398 | 50184839 |
Blood sodium increased | 12.81 | 9.79 | 44 | 386843 | 2358 | 50215879 |
Diabetes mellitus | 12.81 | 9.79 | 477 | 386410 | 48556 | 50169681 |
Venous aneurysm | 12.78 | 9.79 | 4 | 386883 | 4 | 50218233 |
Jaundice hepatocellular | 12.77 | 9.79 | 6 | 386881 | 30 | 50218207 |
Sinus node dysfunction | 12.76 | 9.79 | 62 | 386825 | 3893 | 50214344 |
Heat illness | 12.74 | 9.79 | 10 | 386877 | 141 | 50218096 |
Metastatic renal cell carcinoma | 12.68 | 9.79 | 22 | 386865 | 758 | 50217479 |
Cerebral atrophy | 12.67 | 9.79 | 69 | 386818 | 4532 | 50213705 |
Pulmonary hypertension | 12.66 | 9.79 | 340 | 386547 | 33077 | 50185160 |
Bowel movement irregularity | 12.66 | 9.79 | 62 | 386825 | 3906 | 50214331 |
Diffuse large B-cell lymphoma refractory | 12.65 | 9.79 | 26 | 386861 | 1020 | 50217217 |
Duodenal ulcer | 12.65 | 9.79 | 92 | 386795 | 6683 | 50211554 |
Multiple drug therapy | 12.62 | 9.79 | 38 | 386849 | 1899 | 50216338 |
Nephropathy | 12.61 | 9.79 | 76 | 386811 | 5182 | 50213055 |
Psychogenic visual disorder | 12.59 | 9.79 | 5 | 386882 | 15 | 50218222 |
Renal aneurysm | 12.59 | 9.79 | 5 | 386882 | 15 | 50218222 |
Hepatorenal failure | 12.52 | 9.79 | 19 | 386868 | 584 | 50217653 |
Maternal exposure timing unspecified | 12.50 | 9.79 | 6 | 386881 | 3614 | 50214623 |
Dislocation of vertebra | 12.50 | 9.79 | 4 | 386883 | 3083 | 50215154 |
Femoral neck fracture | 12.47 | 9.79 | 99 | 386788 | 7391 | 50210846 |
Eye oedema | 12.43 | 9.79 | 30 | 386857 | 1313 | 50216924 |
Duodenal ulcer repair | 12.43 | 9.79 | 7 | 386880 | 54 | 50218183 |
Small cell carcinoma | 12.40 | 9.79 | 10 | 386877 | 147 | 50218090 |
Gingival disorder | 12.39 | 9.79 | 53 | 386834 | 3152 | 50215085 |
Normal newborn | 12.37 | 9.79 | 20 | 386867 | 6671 | 50211566 |
Blood cholinesterase increased | 12.35 | 9.79 | 5 | 386882 | 16 | 50218221 |
Thalamus haemorrhage | 12.35 | 9.79 | 19 | 386868 | 591 | 50217646 |
Ocular icterus | 12.33 | 9.79 | 56 | 386831 | 3419 | 50214818 |
Hospice care | 12.33 | 9.79 | 81 | 386806 | 5691 | 50212546 |
Bromhidrosis | 12.32 | 9.79 | 4 | 386883 | 5 | 50218232 |
Lymphadenopathy | 12.29 | 9.79 | 181 | 386706 | 33318 | 50184919 |
Gastrointestinal stromal tumour | 12.29 | 9.79 | 24 | 386863 | 907 | 50217330 |
Concomitant disease progression | 12.28 | 9.79 | 39 | 386848 | 2006 | 50216231 |
Hypoacusis | 12.26 | 9.79 | 224 | 386663 | 20423 | 50197814 |
Retinopathy hypertensive | 12.24 | 9.79 | 12 | 386875 | 231 | 50218006 |
Biopsy kidney | 12.20 | 9.79 | 9 | 386878 | 115 | 50218122 |
Sensorimotor disorder | 12.20 | 9.79 | 16 | 386871 | 428 | 50217809 |
Sudden hearing loss | 12.16 | 9.79 | 26 | 386861 | 1049 | 50217188 |
Injection site induration | 12.15 | 9.79 | 29 | 386858 | 8368 | 50209869 |
Enterochromaffin cell hyperplasia | 12.11 | 9.79 | 7 | 386880 | 57 | 50218180 |
Acute pulmonary oedema | 12.07 | 9.79 | 96 | 386791 | 7171 | 50211066 |
Rales | 12.05 | 9.79 | 123 | 386764 | 9855 | 50208382 |
Ventricular internal diameter abnormal | 12.03 | 9.79 | 6 | 386881 | 35 | 50218202 |
Anti-erythropoietin antibody positive | 12.00 | 9.79 | 15 | 386872 | 382 | 50217855 |
Hand dermatitis | 12.00 | 9.79 | 8 | 386879 | 86 | 50218151 |
Bladder sphincter atony | 11.97 | 9.79 | 10 | 386877 | 155 | 50218082 |
Muscular weakness | 11.96 | 9.79 | 862 | 386025 | 94151 | 50124086 |
Hypophagia | 11.94 | 9.79 | 287 | 386600 | 27441 | 50190796 |
Faeces hard | 11.93 | 9.79 | 33 | 386854 | 1571 | 50216666 |
Hypoxia | 11.87 | 9.79 | 491 | 386396 | 50632 | 50167605 |
Breast cancer stage III | 11.87 | 9.79 | 5 | 386882 | 3251 | 50214986 |
Bifascicular block | 11.82 | 9.79 | 9 | 386878 | 121 | 50218116 |
Blood phosphorus increased | 11.82 | 9.79 | 45 | 386842 | 2537 | 50215700 |
Agitation | 11.81 | 9.79 | 314 | 386573 | 53070 | 50165167 |
Dry skin | 11.73 | 9.79 | 422 | 386465 | 42769 | 50175468 |
Renal function test abnormal | 11.71 | 9.79 | 48 | 386839 | 2801 | 50215436 |
Cytotoxic oedema | 11.70 | 9.79 | 9 | 386878 | 123 | 50218114 |
Gamma-glutamyltransferase increased | 11.69 | 9.79 | 303 | 386584 | 29320 | 50188917 |
Immune reconstitution inflammatory syndrome | 11.67 | 9.79 | 15 | 386872 | 5501 | 50212736 |
Glucose tolerance impaired | 11.65 | 9.79 | 73 | 386814 | 5045 | 50213192 |
Tongue abscess | 11.64 | 9.79 | 3 | 386884 | 0 | 50218237 |
Adrenal gland cancer metastatic | 11.64 | 9.79 | 3 | 386884 | 0 | 50218237 |
Cardiac index increased | 11.64 | 9.79 | 3 | 386884 | 0 | 50218237 |
Typical aura without headache | 11.64 | 9.79 | 3 | 386884 | 0 | 50218237 |
Peripheral nerve paresis | 11.64 | 9.79 | 3 | 386884 | 0 | 50218237 |
Blood pressure difference of extremities | 11.64 | 9.79 | 3 | 386884 | 0 | 50218237 |
Mixed dementia | 11.64 | 9.79 | 3 | 386884 | 0 | 50218237 |
Carbohydrate metabolism disorder | 11.64 | 9.79 | 3 | 386884 | 0 | 50218237 |
Azotaemia | 11.64 | 9.79 | 61 | 386826 | 3947 | 50214290 |
Skin exfoliation | 11.62 | 9.79 | 338 | 386549 | 33274 | 50184963 |
Congenital diaphragmatic hernia | 11.60 | 9.79 | 11 | 386876 | 203 | 50218034 |
Urinary incontinence | 11.56 | 9.79 | 290 | 386597 | 27918 | 50190319 |
Yellow skin | 11.56 | 9.79 | 38 | 386849 | 1991 | 50216246 |
Leukaemic infiltration renal | 11.51 | 9.79 | 5 | 386882 | 20 | 50218217 |
Retroperitoneal oedema | 11.51 | 9.79 | 5 | 386882 | 20 | 50218217 |
Pernicious anaemia | 11.50 | 9.79 | 19 | 386868 | 629 | 50217608 |
Vaginal haemorrhage | 11.49 | 9.79 | 126 | 386761 | 24425 | 50193812 |
Head banging | 11.48 | 9.79 | 15 | 386872 | 400 | 50217837 |
Device use error | 11.47 | 9.79 | 14 | 386873 | 5252 | 50212985 |
Cerebellar haemorrhage | 11.47 | 9.79 | 28 | 386859 | 1235 | 50217002 |
Brain stem infarction | 11.46 | 9.79 | 21 | 386866 | 756 | 50217481 |
Tonsillar inflammation | 11.41 | 9.79 | 8 | 386879 | 94 | 50218143 |
Blood lactic acid | 11.34 | 9.79 | 8 | 386879 | 95 | 50218142 |
Internal haemorrhage | 11.34 | 9.79 | 65 | 386822 | 4352 | 50213885 |
Liver injury | 11.33 | 9.79 | 128 | 386759 | 24678 | 50193559 |
Congenital syphilitic osteochondritis | 11.32 | 9.79 | 5 | 386882 | 21 | 50218216 |
Hallucination, visual | 11.32 | 9.79 | 184 | 386703 | 16398 | 50201839 |
Cardiac hypertrophy | 11.28 | 9.79 | 24 | 386863 | 965 | 50217272 |
Aggression | 11.28 | 9.79 | 105 | 386782 | 21011 | 50197226 |
Hypereosinophilic syndrome | 11.22 | 9.79 | 12 | 386875 | 257 | 50217980 |
Pulmonary arterial hypertension | 11.22 | 9.79 | 218 | 386669 | 20101 | 50198136 |
Synovial cyst | 11.20 | 9.79 | 29 | 386858 | 8137 | 50210100 |
Rheumatoid factor negative | 11.20 | 9.79 | 18 | 386869 | 582 | 50217655 |
Hypertonic bladder | 11.13 | 9.79 | 49 | 386838 | 2951 | 50215286 |
Oesophageal food impaction | 11.11 | 9.79 | 10 | 386877 | 172 | 50218065 |
Drug tolerance | 11.09 | 9.79 | 13 | 386874 | 4963 | 50213274 |
Malignant hypertension | 11.05 | 9.79 | 25 | 386862 | 1049 | 50217188 |
Dilatation ventricular | 11.04 | 9.79 | 41 | 386846 | 2284 | 50215953 |
Myoglobin blood increased | 11.04 | 9.79 | 28 | 386859 | 1265 | 50216972 |
Colitis ischaemic | 11.02 | 9.79 | 116 | 386771 | 9367 | 50208870 |
Gastric pH increased | 11.02 | 9.79 | 6 | 386881 | 43 | 50218194 |
Gastric cancer | 10.98 | 9.79 | 49 | 386838 | 2969 | 50215268 |
Cardiac valve sclerosis | 10.97 | 9.79 | 5 | 386882 | 23 | 50218214 |
Porphyrins urine increased | 10.97 | 9.79 | 5 | 386882 | 23 | 50218214 |
Acquired porphyria | 10.97 | 9.79 | 5 | 386882 | 23 | 50218214 |
Flatulence | 10.96 | 9.79 | 299 | 386588 | 29159 | 50189078 |
Peritonitis bacterial | 10.94 | 9.79 | 67 | 386820 | 4594 | 50213643 |
Gastric cyst | 10.93 | 9.79 | 8 | 386879 | 101 | 50218136 |
Graft versus host disease in skin | 10.92 | 9.79 | 3 | 386884 | 2553 | 50215684 |
Renal neoplasm | 10.89 | 9.79 | 25 | 386862 | 1059 | 50217178 |
Fibrosis | 10.87 | 9.79 | 57 | 386830 | 3690 | 50214547 |
Menstruation irregular | 10.86 | 9.79 | 19 | 386868 | 6143 | 50212094 |
Therapeutic product effect increased | 10.84 | 9.79 | 24 | 386863 | 992 | 50217245 |
Nephrotic syndrome | 10.84 | 9.79 | 68 | 386819 | 4702 | 50213535 |
Base excess decreased | 10.84 | 9.79 | 7 | 386880 | 71 | 50218166 |
Pulmonary alveolar haemorrhage | 10.82 | 9.79 | 60 | 386827 | 3967 | 50214270 |
Joint range of motion decreased | 10.79 | 9.79 | 90 | 386797 | 18422 | 50199815 |
End stage renal disease | 10.77 | 9.79 | 78 | 386809 | 5659 | 50212578 |
Chromaturia | 10.76 | 9.79 | 164 | 386723 | 14426 | 50203811 |
Haemorrhagic erosive gastritis | 10.76 | 9.79 | 12 | 386875 | 270 | 50217967 |
Osteoarthritis | 10.76 | 9.79 | 422 | 386465 | 68184 | 50150053 |
Hypertensive urgency | 10.75 | 9.79 | 10 | 386877 | 180 | 50218057 |
Urine flow decreased | 10.73 | 9.79 | 11 | 386876 | 224 | 50218013 |
Disease recurrence | 10.66 | 9.79 | 100 | 386787 | 19981 | 50198256 |
Dry eye | 10.57 | 9.79 | 177 | 386710 | 31918 | 50186319 |
Glomerulonephritis | 10.55 | 9.79 | 31 | 386856 | 1528 | 50216709 |
Peritoneal dialysis complication | 10.53 | 9.79 | 26 | 386861 | 1155 | 50217082 |
Hyperparathyroidism primary | 10.50 | 9.79 | 13 | 386874 | 328 | 50217909 |
Pulmonary hypoplasia | 10.48 | 9.79 | 12 | 386875 | 278 | 50217959 |
Orthopnoea | 10.48 | 9.79 | 77 | 386810 | 5612 | 50212625 |
Bacteriuria | 10.41 | 9.79 | 19 | 386868 | 682 | 50217555 |
Small for dates baby | 10.40 | 9.79 | 7 | 386880 | 3498 | 50214739 |
Neurofibrosarcoma | 10.38 | 9.79 | 9 | 386878 | 147 | 50218090 |
Pneumonia viral | 10.38 | 9.79 | 23 | 386864 | 6811 | 50211426 |
Mouth haemorrhage | 10.37 | 9.79 | 82 | 386805 | 6114 | 50212123 |
Subarachnoid haemorrhage | 10.35 | 9.79 | 127 | 386760 | 10649 | 50207588 |
Acute graft versus host disease | 10.35 | 9.79 | 9 | 386878 | 3949 | 50214288 |
Therapeutic drug monitoring analysis not performed | 10.33 | 9.79 | 19 | 386868 | 686 | 50217551 |
Renal cyst infection | 10.30 | 9.79 | 8 | 386879 | 111 | 50218126 |
Sinoatrial block | 10.26 | 9.79 | 20 | 386867 | 755 | 50217482 |
Oesophageal carcinoma recurrent | 10.19 | 9.79 | 5 | 386882 | 28 | 50218209 |
Iliac artery occlusion | 10.19 | 9.79 | 9 | 386878 | 151 | 50218086 |
Skin toxicity | 10.11 | 9.79 | 9 | 386878 | 3904 | 50214333 |
Oesophageal atresia | 10.09 | 9.79 | 16 | 386871 | 511 | 50217726 |
Periarticular disorder | 10.07 | 9.79 | 6 | 386881 | 52 | 50218185 |
Oculomucocutaneous syndrome | 10.07 | 9.79 | 8 | 386879 | 115 | 50218122 |
Haemorrhagic diathesis | 10.07 | 9.79 | 58 | 386829 | 3890 | 50214347 |
Haematoma | 10.06 | 9.79 | 305 | 386582 | 30205 | 50188032 |
Pneumothorax traumatic | 10.04 | 9.79 | 9 | 386878 | 154 | 50218083 |
Oesophageal achalasia | 10.01 | 9.79 | 14 | 386873 | 399 | 50217838 |
Carcinoid tumour of the stomach | 9.99 | 9.79 | 9 | 386878 | 155 | 50218082 |
Cardiovascular disorder | 9.95 | 9.79 | 123 | 386764 | 10331 | 50207906 |
Tracheo-oesophageal fistula | 9.94 | 9.79 | 16 | 386871 | 518 | 50217719 |
Cerebrovascular insufficiency | 9.93 | 9.79 | 7 | 386880 | 83 | 50218154 |
Psychomotor retardation | 9.91 | 9.79 | 52 | 386835 | 3366 | 50214871 |
Porphyrins stool increased | 9.91 | 9.79 | 5 | 386882 | 30 | 50218207 |
Femoral artery dissection | 9.91 | 9.79 | 5 | 386882 | 30 | 50218207 |
Interstitial granulomatous dermatitis | 9.91 | 9.79 | 5 | 386882 | 30 | 50218207 |
Congenital uterine anomaly | 9.90 | 9.79 | 8 | 386879 | 118 | 50218119 |
Carcinoid tumour | 9.90 | 9.79 | 12 | 386875 | 296 | 50217941 |
Contusion | 9.87 | 9.79 | 731 | 386156 | 111452 | 50106785 |
Blood sodium abnormal | 9.86 | 9.79 | 18 | 386869 | 646 | 50217591 |
Urate nephropathy | 9.84 | 9.79 | 8 | 386879 | 119 | 50218118 |
Traumatic haemorrhage | 9.84 | 9.79 | 15 | 386872 | 463 | 50217774 |
Vascular pseudoaneurysm | 9.83 | 9.79 | 28 | 386859 | 1356 | 50216881 |
Drug screen positive | 9.82 | 9.79 | 7 | 386880 | 3395 | 50214842 |
Change of bowel habit | 9.80 | 9.79 | 33 | 386854 | 1751 | 50216486 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 600.81 | 11.01 | 2198 | 308502 | 88048 | 29175779 |
Gingival hypertrophy | 390.47 | 11.01 | 234 | 310466 | 1431 | 29262396 |
Drug abuse | 389.02 | 11.01 | 176 | 310524 | 79707 | 29184120 |
Off label use | 337.69 | 11.01 | 1822 | 308878 | 298978 | 28964849 |
Drug ineffective | 324.15 | 11.01 | 2362 | 308338 | 360808 | 28903019 |
Blood pressure inadequately controlled | 261.49 | 11.01 | 210 | 310490 | 2176 | 29261651 |
Shock | 214.94 | 11.01 | 601 | 310099 | 20803 | 29243024 |
Hypertensive crisis | 181.77 | 11.01 | 309 | 310391 | 7539 | 29256288 |
Neutropenia | 176.25 | 11.01 | 748 | 309952 | 130963 | 29132864 |
Foetal exposure during pregnancy | 175.40 | 11.01 | 68 | 310632 | 33799 | 29230028 |
Product use in unapproved indication | 173.40 | 11.01 | 412 | 310288 | 86463 | 29177364 |
Intentional overdose | 168.95 | 11.01 | 827 | 309873 | 37701 | 29226126 |
Hypotension | 165.88 | 11.01 | 2915 | 307785 | 191439 | 29072388 |
Febrile neutropenia | 165 | 11.01 | 614 | 310086 | 111626 | 29152201 |
Oedema peripheral | 158.72 | 11.01 | 1725 | 308975 | 101832 | 29161995 |
Treatment failure | 148.58 | 11.01 | 103 | 310597 | 36836 | 29226991 |
Bradycardia | 142.31 | 11.01 | 1177 | 309523 | 64452 | 29199375 |
Angioedema | 139.15 | 11.01 | 684 | 310016 | 31231 | 29232596 |
Non-cardiogenic pulmonary oedema | 138.99 | 11.01 | 85 | 310615 | 542 | 29263285 |
Acute kidney injury | 136.88 | 11.01 | 3700 | 307000 | 261567 | 29002260 |
Death | 133.96 | 11.01 | 2663 | 308037 | 339421 | 28924406 |
Distributive shock | 121.57 | 11.01 | 93 | 310607 | 892 | 29262935 |
Blood pressure increased | 116.07 | 11.01 | 1236 | 309464 | 72567 | 29191260 |
Syncope | 109.12 | 11.01 | 1321 | 309379 | 80050 | 29183777 |
Cerebral infarction | 103.42 | 11.01 | 523 | 310177 | 24152 | 29239675 |
Angina pectoris | 93.66 | 11.01 | 556 | 310144 | 27294 | 29236533 |
Blood creatinine increased | 90.22 | 11.01 | 1324 | 309376 | 83778 | 29180049 |
Thrombocytopenia | 89.74 | 11.01 | 944 | 309756 | 133879 | 29129948 |
Drug resistance | 82.78 | 11.01 | 63 | 310637 | 21477 | 29242350 |
Swollen tongue | 82.42 | 11.01 | 300 | 310400 | 11966 | 29251861 |
Lip swelling | 77.12 | 11.01 | 296 | 310404 | 12114 | 29251713 |
Premature baby | 76.64 | 11.01 | 43 | 310657 | 17237 | 29246590 |
Hyperkalaemia | 75.98 | 11.01 | 982 | 309718 | 60410 | 29203417 |
Hypokalaemia | 75.28 | 11.01 | 833 | 309867 | 49370 | 29214457 |
Drug dependence | 73.67 | 11.01 | 67 | 310633 | 20914 | 29242913 |
Renal impairment | 71.69 | 11.01 | 1227 | 309473 | 80106 | 29183721 |
Blood pressure systolic increased | 69.15 | 11.01 | 355 | 310345 | 16490 | 29247337 |
Cerebrovascular accident | 69.13 | 11.01 | 1164 | 309536 | 75747 | 29188080 |
Chronic kidney disease | 68.42 | 11.01 | 633 | 310067 | 35783 | 29228044 |
Rhabdomyolysis | 66.37 | 11.01 | 951 | 309749 | 59857 | 29203970 |
Immune reconstitution inflammatory syndrome | 65.90 | 11.01 | 4 | 310696 | 7798 | 29256029 |
Pancytopenia | 65.23 | 11.01 | 559 | 310141 | 82609 | 29181218 |
Metabolic acidosis | 63.54 | 11.01 | 640 | 310060 | 37022 | 29226805 |
Aggression | 60.66 | 11.01 | 182 | 310518 | 35359 | 29228468 |
Sepsis | 59.75 | 11.01 | 1097 | 309603 | 141585 | 29122242 |
Pyrexia | 59.44 | 11.01 | 2445 | 308255 | 285177 | 28978650 |
Product use issue | 58.79 | 11.01 | 309 | 310391 | 51135 | 29212692 |
Infusion related reaction | 58.73 | 11.01 | 249 | 310451 | 43637 | 29220190 |
Dizziness | 58.29 | 11.01 | 2492 | 308208 | 187192 | 29076635 |
Pathogen resistance | 56.04 | 11.01 | 9 | 310691 | 8107 | 29255720 |
Suspected suicide | 53.97 | 11.01 | 126 | 310574 | 3894 | 29259933 |
Exposure during pregnancy | 51.74 | 11.01 | 13 | 310687 | 8541 | 29255286 |
Leukopenia | 49.81 | 11.01 | 357 | 310343 | 54846 | 29208981 |
Rheumatoid arthritis | 49.74 | 11.01 | 172 | 310528 | 31980 | 29231847 |
Septic shock | 47.04 | 11.01 | 425 | 310275 | 62135 | 29201692 |
Mucosal inflammation | 46.89 | 11.01 | 172 | 310528 | 31423 | 29232404 |
Progressive multifocal leukoencephalopathy | 45.98 | 11.01 | 17 | 310683 | 8702 | 29255125 |
Vasoplegia syndrome | 45.46 | 11.01 | 67 | 310633 | 1441 | 29262386 |
Nephrotic syndrome | 45.27 | 11.01 | 158 | 310542 | 6170 | 29257657 |
Multiple organ dysfunction syndrome | 45.21 | 11.01 | 434 | 310266 | 62682 | 29201145 |
Myalgia | 44.28 | 11.01 | 1054 | 309646 | 72965 | 29190862 |
Myocardial depression | 44.16 | 11.01 | 18 | 310682 | 38 | 29263789 |
Suicide attempt | 44.04 | 11.01 | 550 | 310150 | 33560 | 29230267 |
Glycosylated haemoglobin increased | 43.94 | 11.01 | 206 | 310494 | 9220 | 29254607 |
Proteinuria | 43.54 | 11.01 | 300 | 310400 | 15504 | 29248323 |
Chronic pigmented purpura | 43.42 | 11.01 | 22 | 310678 | 91 | 29263736 |
Gingival swelling | 42.47 | 11.01 | 56 | 310644 | 1081 | 29262746 |
Lactic acidosis | 42.22 | 11.01 | 495 | 310205 | 29752 | 29234075 |
Agitation | 41.94 | 11.01 | 341 | 310359 | 50963 | 29212864 |
Pemphigoid | 41.64 | 11.01 | 174 | 310526 | 7407 | 29256420 |
Renal cell carcinoma | 41.49 | 11.01 | 126 | 310574 | 4570 | 29259257 |
Acute graft versus host disease | 41.26 | 11.01 | 6 | 310694 | 5818 | 29258009 |
Palmar-plantar erythrodysaesthesia syndrome | 41.16 | 11.01 | 281 | 310419 | 14478 | 29249349 |
Seizure | 41.15 | 11.01 | 709 | 309991 | 92414 | 29171413 |
Renal artery stenosis | 39.96 | 11.01 | 73 | 310627 | 1888 | 29261939 |
Pulmonary oedema | 39.92 | 11.01 | 651 | 310049 | 42084 | 29221743 |
Myelosuppression | 39.51 | 11.01 | 42 | 310658 | 12185 | 29251642 |
Cardiac failure congestive | 39.47 | 11.01 | 1069 | 309631 | 75512 | 29188315 |
Drug ineffective for unapproved indication | 39.41 | 11.01 | 55 | 310645 | 14159 | 29249668 |
Synovitis | 39.16 | 11.01 | 34 | 310666 | 10856 | 29252971 |
Infective pulmonary exacerbation of cystic fibrosis | 38.65 | 11.01 | 9 | 310691 | 6227 | 29257600 |
Tachycardia | 38.55 | 11.01 | 532 | 310168 | 71878 | 29191949 |
Cytokine release syndrome | 38.16 | 11.01 | 49 | 310651 | 13070 | 29250757 |
Atrioventricular block complete | 38.02 | 11.01 | 176 | 310524 | 7835 | 29255992 |
Orthostatic hypotension | 37.89 | 11.01 | 384 | 310316 | 22245 | 29241582 |
Suicidal ideation | 37.74 | 11.01 | 212 | 310488 | 34504 | 29229323 |
Depression | 37.71 | 11.01 | 648 | 310052 | 84499 | 29179328 |
Contraindicated product administered | 37.70 | 11.01 | 85 | 310615 | 18181 | 29245646 |
C-reactive protein abnormal | 37.53 | 11.01 | 11 | 310689 | 6525 | 29257302 |
Hypomagnesaemia | 37.12 | 11.01 | 312 | 310388 | 17156 | 29246671 |
Sedation | 36.74 | 11.01 | 80 | 310620 | 17325 | 29246502 |
Intentional product use issue | 36.34 | 11.01 | 279 | 310421 | 42219 | 29221608 |
Haemophagocytic lymphohistiocytosis | 36.33 | 11.01 | 34 | 310666 | 10470 | 29253357 |
Gastrointestinal tract mucosal pigmentation | 36.32 | 11.01 | 31 | 310669 | 352 | 29263475 |
Bronchopulmonary aspergillosis | 36.02 | 11.01 | 46 | 310654 | 12298 | 29251529 |
5-hydroxyindolacetic acid in urine increased | 35.64 | 11.01 | 25 | 310675 | 207 | 29263620 |
Dermatomyositis | 35.17 | 11.01 | 49 | 310651 | 999 | 29262828 |
Thalamus haemorrhage | 34.96 | 11.01 | 46 | 310654 | 886 | 29262941 |
Interstitial lung disease | 34.85 | 11.01 | 823 | 309877 | 56895 | 29206932 |
Hypertension | 34.62 | 11.01 | 1527 | 309173 | 115087 | 29148740 |
Aspergillus infection | 34.58 | 11.01 | 36 | 310664 | 10545 | 29253282 |
Hypoglycaemia | 34.14 | 11.01 | 705 | 309995 | 47641 | 29216186 |
Post transplant lymphoproliferative disorder | 33.90 | 11.01 | 8 | 310692 | 5485 | 29258342 |
Injection site pain | 33.73 | 11.01 | 201 | 310499 | 32245 | 29231582 |
Nocturia | 33.47 | 11.01 | 175 | 310525 | 8187 | 29255640 |
Infection | 33.37 | 11.01 | 586 | 310114 | 76165 | 29187662 |
Bone marrow failure | 32.98 | 11.01 | 162 | 310538 | 27287 | 29236540 |
Abnormal behaviour | 32.32 | 11.01 | 129 | 310571 | 22998 | 29240829 |
Haematotoxicity | 32.20 | 11.01 | 15 | 310685 | 6684 | 29257143 |
Cytomegalovirus infection | 32.12 | 11.01 | 130 | 310570 | 23085 | 29240742 |
Renal failure | 31.75 | 11.01 | 1537 | 309163 | 117062 | 29146765 |
Diastolic dysfunction | 31.64 | 11.01 | 121 | 310579 | 4943 | 29258884 |
Gingival bleeding | 31.54 | 11.01 | 143 | 310557 | 6310 | 29257517 |
Product monitoring error | 31.34 | 11.01 | 79 | 310621 | 2566 | 29261261 |
Respiratory depression | 31.23 | 11.01 | 59 | 310641 | 13464 | 29250363 |
Wrong technique in product usage process | 30.95 | 11.01 | 198 | 310502 | 31230 | 29232597 |
Carotid artery stenosis | 30.61 | 11.01 | 110 | 310590 | 4359 | 29259468 |
Multiple-drug resistance | 30.13 | 11.01 | 3 | 310697 | 3897 | 29259930 |
Graft versus host disease | 30.09 | 11.01 | 34 | 310666 | 9594 | 29254233 |
Irritability | 30.05 | 11.01 | 125 | 310575 | 22027 | 29241800 |
Peripheral swelling | 29.57 | 11.01 | 878 | 309822 | 62861 | 29200966 |
Plasmapheresis | 29.07 | 11.01 | 25 | 310675 | 287 | 29263540 |
Polymyositis | 29.06 | 11.01 | 51 | 310649 | 1277 | 29262550 |
Sinus bradycardia | 28.92 | 11.01 | 215 | 310485 | 11388 | 29252439 |
Chronic graft versus host disease | 28.89 | 11.01 | 4 | 310696 | 4025 | 29259802 |
Febrile bone marrow aplasia | 28.89 | 11.01 | 21 | 310679 | 7330 | 29256497 |
Substance abuse | 28.53 | 11.01 | 18 | 310682 | 6769 | 29257058 |
Primary hyperaldosteronism | 28.37 | 11.01 | 14 | 310686 | 54 | 29263773 |
Therapeutic product effect decreased | 28.27 | 11.01 | 187 | 310513 | 29264 | 29234563 |
Disease progression | 27.68 | 11.01 | 652 | 310048 | 81264 | 29182563 |
Psychotic disorder | 27.52 | 11.01 | 115 | 310585 | 20239 | 29243588 |
Mucormycosis | 27.29 | 11.01 | 10 | 310690 | 5148 | 29258679 |
Cardiogenic shock | 27.20 | 11.01 | 315 | 310385 | 18875 | 29244952 |
Electrocardiogram QRS complex prolonged | 27.17 | 11.01 | 100 | 310600 | 4010 | 29259817 |
Vertebral osteophyte | 26.97 | 11.01 | 13 | 310687 | 47 | 29263780 |
Myocardial infarction | 26.96 | 11.01 | 1417 | 309283 | 108879 | 29154948 |
Palpitations | 26.94 | 11.01 | 487 | 310213 | 32117 | 29231710 |
Sinusitis | 26.85 | 11.01 | 231 | 310469 | 34119 | 29229708 |
Breath sounds abnormal | 26.72 | 11.01 | 121 | 310579 | 5336 | 29258491 |
Macroglossia | 26.65 | 11.01 | 26 | 310674 | 355 | 29263472 |
Transient ischaemic attack | 26.60 | 11.01 | 367 | 310333 | 22903 | 29240924 |
Myelodysplastic syndrome | 26.31 | 11.01 | 97 | 310603 | 17697 | 29246130 |
Eczema | 26.29 | 11.01 | 241 | 310459 | 13585 | 29250242 |
Accelerated hypertension | 26.27 | 11.01 | 21 | 310679 | 216 | 29263611 |
Pseudolymphoma | 26.23 | 11.01 | 30 | 310670 | 497 | 29263330 |
Pelvic mass | 26.13 | 11.01 | 20 | 310680 | 192 | 29263635 |
Neutrophil count decreased | 25.79 | 11.01 | 313 | 310387 | 43254 | 29220573 |
Hyperplasia | 25.77 | 11.01 | 30 | 310670 | 507 | 29263320 |
Periodontitis | 25.55 | 11.01 | 58 | 310642 | 1759 | 29262068 |
Akathisia | 25.54 | 11.01 | 20 | 310680 | 6722 | 29257105 |
Coma | 25.47 | 11.01 | 278 | 310422 | 39172 | 29224655 |
Stenosis | 25.45 | 11.01 | 42 | 310658 | 999 | 29262828 |
Staphylococcal infection | 25.45 | 11.01 | 191 | 310509 | 29049 | 29234778 |
Loss of consciousness | 25.44 | 11.01 | 985 | 309715 | 73071 | 29190756 |
Candida infection | 25.23 | 11.01 | 79 | 310621 | 15146 | 29248681 |
Hypertensive heart disease | 25.03 | 11.01 | 63 | 310637 | 2044 | 29261783 |
Metastatic renal cell carcinoma | 24.87 | 11.01 | 59 | 310641 | 1843 | 29261984 |
Hyponatraemia | 24.78 | 11.01 | 906 | 309794 | 66727 | 29197100 |
Orbital myositis | 24.74 | 11.01 | 16 | 310684 | 114 | 29263713 |
Drug withdrawal syndrome | 24.69 | 11.01 | 101 | 310599 | 17883 | 29245944 |
Atrioventricular block first degree | 24.61 | 11.01 | 116 | 310584 | 5203 | 29258624 |
Blood mercury abnormal | 24.36 | 11.01 | 19 | 310681 | 188 | 29263639 |
Acute hepatic failure | 24.35 | 11.01 | 56 | 310644 | 11896 | 29251931 |
Diabetes mellitus inadequate control | 24.35 | 11.01 | 214 | 310486 | 11920 | 29251907 |
Coronary artery disease | 24.24 | 11.01 | 622 | 310078 | 43568 | 29220259 |
Condition aggravated | 24.20 | 11.01 | 1273 | 309427 | 145022 | 29118805 |
Aortic dissection | 23.98 | 11.01 | 67 | 310633 | 2317 | 29261510 |
Lymphadenopathy | 23.56 | 11.01 | 160 | 310540 | 24889 | 29238938 |
Clear cell renal cell carcinoma | 23.55 | 11.01 | 40 | 310660 | 975 | 29262852 |
Disease recurrence | 23.37 | 11.01 | 87 | 310613 | 15827 | 29248000 |
Acute myocardial infarction | 22.94 | 11.01 | 669 | 310031 | 47769 | 29216058 |
Adenovirus infection | 22.90 | 11.01 | 9 | 310691 | 4438 | 29259389 |
Diabetic nephropathy | 22.87 | 11.01 | 57 | 310643 | 1838 | 29261989 |
Erectile dysfunction | 22.65 | 11.01 | 289 | 310411 | 17720 | 29246107 |
Carotid sinus syndrome | 22.61 | 11.01 | 10 | 310690 | 28 | 29263799 |
Overdose | 22.31 | 11.01 | 1039 | 309661 | 78780 | 29185047 |
Dystonia | 22.11 | 11.01 | 43 | 310657 | 9706 | 29254121 |
Ventricular septal defect | 22.06 | 11.01 | 5 | 310695 | 3524 | 29260303 |
Alcohol abuse | 21.94 | 11.01 | 9 | 310691 | 4324 | 29259503 |
Tongue oedema | 21.88 | 11.01 | 68 | 310632 | 2498 | 29261329 |
Hepatojugular reflux | 21.78 | 11.01 | 26 | 310674 | 452 | 29263375 |
Hospitalisation | 21.65 | 11.01 | 346 | 310354 | 45642 | 29218185 |
Maternal drugs affecting foetus | 21.54 | 11.01 | 7 | 310693 | 3886 | 29259941 |
Dyskinesia | 21.53 | 11.01 | 123 | 310577 | 19938 | 29243889 |
Drug intolerance | 21.46 | 11.01 | 368 | 310332 | 48011 | 29215816 |
Cytomegalovirus chorioretinitis | 21.46 | 11.01 | 4 | 310696 | 3234 | 29260593 |
Asthma | 21.45 | 11.01 | 486 | 310214 | 33363 | 29230464 |
Carotid arteriosclerosis | 21.45 | 11.01 | 47 | 310653 | 1391 | 29262436 |
Obstructive airways disorder | 21.45 | 11.01 | 193 | 310507 | 10823 | 29253004 |
Hypoinsulinaemia | 21.40 | 11.01 | 6 | 310694 | 0 | 29263827 |
Leukaemoid reaction | 21.24 | 11.01 | 13 | 310687 | 83 | 29263744 |
Drug use disorder | 21.09 | 11.01 | 5 | 310695 | 3417 | 29260410 |
Device issue | 20.68 | 11.01 | 31 | 310669 | 7749 | 29256078 |
Gout | 20.68 | 11.01 | 270 | 310430 | 16641 | 29247186 |
Pulmonary embolism | 20.66 | 11.01 | 629 | 310071 | 75905 | 29187922 |
Hyperdynamic left ventricle | 20.65 | 11.01 | 14 | 310686 | 109 | 29263718 |
Cytomegalovirus infection reactivation | 20.56 | 11.01 | 5 | 310695 | 3359 | 29260468 |
Lung diffusion test decreased | 20.53 | 11.01 | 28 | 310672 | 559 | 29263268 |
Psoriatic arthropathy | 20.49 | 11.01 | 82 | 310618 | 14609 | 29249218 |
Therapeutic product effect incomplete | 20.47 | 11.01 | 290 | 310410 | 39015 | 29224812 |
Renal disorder | 20.28 | 11.01 | 342 | 310358 | 22253 | 29241574 |
Therapy partial responder | 20.24 | 11.01 | 15 | 310685 | 5184 | 29258643 |
Lipodystrophy acquired | 20.13 | 11.01 | 4 | 310696 | 3090 | 29260737 |
Arthropathy | 20.11 | 11.01 | 138 | 310562 | 21416 | 29242411 |
Status epilepticus | 20.09 | 11.01 | 53 | 310647 | 10741 | 29253086 |
Product dose omission issue | 20.08 | 11.01 | 818 | 309882 | 95565 | 29168262 |
Blood creatine phosphokinase increased | 19.98 | 11.01 | 564 | 310136 | 40080 | 29223747 |
Apparent death | 19.93 | 11.01 | 6 | 310694 | 3498 | 29260329 |
Ear infection | 19.91 | 11.01 | 34 | 310666 | 8066 | 29255761 |
Fall | 19.87 | 11.01 | 2139 | 308561 | 175039 | 29088788 |
Lacunar infarction | 19.83 | 11.01 | 70 | 310630 | 2749 | 29261078 |
Pseudomonas infection | 19.66 | 11.01 | 54 | 310646 | 10798 | 29253029 |
Neurotoxicity | 19.48 | 11.01 | 83 | 310617 | 14530 | 29249297 |
No adverse event | 19.39 | 11.01 | 106 | 310594 | 17372 | 29246455 |
Pneumonia | 19.37 | 11.01 | 3011 | 307689 | 317161 | 28946666 |
Electrocardiogram Q wave abnormal | 19.29 | 11.01 | 20 | 310680 | 295 | 29263532 |
Lymphocele | 19.27 | 11.01 | 43 | 310657 | 1289 | 29262538 |
Brain stem infarction | 19.26 | 11.01 | 39 | 310661 | 1091 | 29262736 |
Blood glucose increased | 19.20 | 11.01 | 780 | 309920 | 58204 | 29205623 |
Bone erosion | 19.19 | 11.01 | 3 | 310697 | 2757 | 29261070 |
Microalbuminuria | 19.17 | 11.01 | 29 | 310671 | 639 | 29263188 |
Dyspnoea | 19.02 | 11.01 | 3798 | 306902 | 322934 | 28940893 |
Venoocclusive liver disease | 18.94 | 11.01 | 27 | 310673 | 6890 | 29256937 |
Atrioventricular block | 18.91 | 11.01 | 132 | 310568 | 6850 | 29256977 |
Small for dates baby | 18.83 | 11.01 | 7 | 310693 | 3572 | 29260255 |
Graft versus host disease in skin | 18.83 | 11.01 | 6 | 310694 | 3373 | 29260454 |
Haemorrhage subcutaneous | 18.76 | 11.01 | 57 | 310643 | 2068 | 29261759 |
Maternal exposure during pregnancy | 18.66 | 11.01 | 10 | 310690 | 4113 | 29259714 |
Mouth swelling | 18.60 | 11.01 | 47 | 310653 | 1529 | 29262298 |
Blood pressure diastolic decreased | 18.58 | 11.01 | 132 | 310568 | 6890 | 29256937 |
Congenital hiatus hernia | 18.45 | 11.01 | 23 | 310677 | 419 | 29263408 |
Zoonotic bacterial infection | 18.43 | 11.01 | 10 | 310690 | 49 | 29263778 |
Chills | 18.27 | 11.01 | 590 | 310110 | 70710 | 29193117 |
Atheroembolism | 18.15 | 11.01 | 17 | 310683 | 220 | 29263607 |
Heart rate decreased | 18.15 | 11.01 | 365 | 310335 | 24547 | 29239280 |
Paranoia | 18.00 | 11.01 | 49 | 310651 | 9828 | 29253999 |
Acute myeloid leukaemia | 17.85 | 11.01 | 101 | 310599 | 16412 | 29247415 |
Nipple inflammation | 17.82 | 11.01 | 10 | 310690 | 53 | 29263774 |
Left ventricular hypertrophy | 17.73 | 11.01 | 126 | 310574 | 6577 | 29257250 |
Intentional self-injury | 17.73 | 11.01 | 69 | 310631 | 12392 | 29251435 |
Diffuse large B-cell lymphoma recurrent | 17.66 | 11.01 | 3 | 310697 | 2594 | 29261233 |
Melaena | 17.44 | 11.01 | 440 | 310260 | 30736 | 29233091 |
Mydriasis | 17.42 | 11.01 | 23 | 310677 | 6062 | 29257765 |
Bundle branch block | 17.31 | 11.01 | 31 | 310669 | 789 | 29263038 |
Hepatic failure | 17.30 | 11.01 | 230 | 310470 | 31282 | 29232545 |
Skin toxicity | 17.28 | 11.01 | 9 | 310691 | 3762 | 29260065 |
Hyperlipidaemia | 17.10 | 11.01 | 205 | 310495 | 12385 | 29251442 |
Angina unstable | 17.06 | 11.01 | 182 | 310518 | 10683 | 29253144 |
Dysmorphism | 17.06 | 11.01 | 5 | 310695 | 2966 | 29260861 |
Haemodynamic instability | 17.05 | 11.01 | 144 | 310556 | 7929 | 29255898 |
Multiple sclerosis relapse | 17.05 | 11.01 | 62 | 310638 | 11357 | 29252470 |
Product substitution issue | 17.00 | 11.01 | 159 | 310541 | 9013 | 29254814 |
Liver carcinoma ruptured | 16.98 | 11.01 | 14 | 310686 | 151 | 29263676 |
Tenosynovitis | 16.97 | 11.01 | 9 | 310691 | 3724 | 29260103 |
Milk-alkali syndrome | 16.91 | 11.01 | 24 | 310676 | 498 | 29263329 |
Fungal infection | 16.88 | 11.01 | 80 | 310620 | 13605 | 29250222 |
Hypertensive emergency | 16.88 | 11.01 | 31 | 310669 | 805 | 29263022 |
Peripheral arterial occlusive disease | 16.84 | 11.01 | 101 | 310599 | 4975 | 29258852 |
Obsessive-compulsive disorder | 16.80 | 11.01 | 14 | 310686 | 4562 | 29259265 |
Myopathy | 16.80 | 11.01 | 177 | 310523 | 10356 | 29253471 |
Hyperuricaemia | 16.80 | 11.01 | 127 | 310573 | 6762 | 29257065 |
Vomiting | 16.77 | 11.01 | 1963 | 308737 | 210297 | 29053530 |
Diabetic neuropathy | 16.75 | 11.01 | 81 | 310619 | 3672 | 29260155 |
Dyspnoea exertional | 16.74 | 11.01 | 502 | 310198 | 35988 | 29227839 |
Deep vein thrombosis | 16.67 | 11.01 | 467 | 310233 | 56932 | 29206895 |
Pollakiuria | 16.66 | 11.01 | 260 | 310440 | 16656 | 29247171 |
Cognitive disorder | 16.64 | 11.01 | 162 | 310538 | 23337 | 29240490 |
Fibrillary glomerulonephritis | 16.60 | 11.01 | 9 | 310691 | 44 | 29263783 |
Stomatitis | 16.56 | 11.01 | 282 | 310418 | 36831 | 29226996 |
Pharyngeal oedema | 16.48 | 11.01 | 110 | 310590 | 5624 | 29258203 |
Swelling face | 16.47 | 11.01 | 303 | 310397 | 20047 | 29243780 |
Acidosis | 16.39 | 11.01 | 165 | 310535 | 9540 | 29254287 |
Neuroleptic malignant syndrome | 16.28 | 11.01 | 101 | 310599 | 16047 | 29247780 |
Epiglottic oedema | 16.26 | 11.01 | 14 | 310686 | 161 | 29263666 |
Haemodialysis | 16.22 | 11.01 | 168 | 310532 | 9786 | 29254041 |
Nasal crusting | 16.18 | 11.01 | 20 | 310680 | 361 | 29263466 |
Pericardial disease | 16.14 | 11.01 | 20 | 310680 | 362 | 29263465 |
Epstein-Barr virus infection | 16.13 | 11.01 | 28 | 310672 | 6601 | 29257226 |
Duodenal ulcer haemorrhage | 16.08 | 11.01 | 91 | 310609 | 4388 | 29259439 |
Cardiomegaly | 16.04 | 11.01 | 218 | 310482 | 13558 | 29250269 |
Cytomegalovirus viraemia | 16.02 | 11.01 | 26 | 310674 | 6294 | 29257533 |
Drug eruption | 15.99 | 11.01 | 256 | 310444 | 16485 | 29247342 |
Chest pain | 15.97 | 11.01 | 1375 | 309325 | 110598 | 29153229 |
Serotonin syndrome | 15.91 | 11.01 | 113 | 310587 | 17399 | 29246428 |
Dermatitis infected | 15.89 | 11.01 | 11 | 310689 | 89 | 29263738 |
Pericardial haemorrhage | 15.88 | 11.01 | 67 | 310633 | 2864 | 29260963 |
Eyelid oedema | 15.86 | 11.01 | 93 | 310607 | 4543 | 29259284 |
Tricuspid valve incompetence | 15.80 | 11.01 | 146 | 310554 | 8248 | 29255579 |
Hypersensitivity vasculitis | 15.78 | 11.01 | 72 | 310628 | 3185 | 29260642 |
Presyncope | 15.73 | 11.01 | 247 | 310453 | 15842 | 29247985 |
Kidney small | 15.70 | 11.01 | 9 | 310691 | 50 | 29263777 |
Ventricular hypertrophy | 15.55 | 11.01 | 87 | 310613 | 4177 | 29259650 |
Osteonecrosis | 15.55 | 11.01 | 81 | 310619 | 13438 | 29250389 |
Hyperglycaemia | 15.54 | 11.01 | 471 | 310229 | 33816 | 29230011 |
Prescription drug used without a prescription | 15.50 | 11.01 | 39 | 310661 | 1265 | 29262562 |
Embolic stroke | 15.50 | 11.01 | 77 | 310623 | 3529 | 29260298 |
Neuropathy peripheral | 15.39 | 11.01 | 600 | 310100 | 70427 | 29193400 |
White blood cell count decreased | 15.39 | 11.01 | 717 | 309983 | 82645 | 29181182 |
Tremor | 15.34 | 11.01 | 624 | 310076 | 72914 | 29190913 |
Musculoskeletal stiffness | 15.32 | 11.01 | 289 | 310411 | 37169 | 29226658 |
Viral infection | 15.26 | 11.01 | 92 | 310608 | 14718 | 29249109 |
Pain | 15.17 | 11.01 | 1573 | 309127 | 169859 | 29093968 |
Hepatic neoplasm | 15.05 | 11.01 | 48 | 310652 | 1788 | 29262039 |
Hydronephrosis | 15.02 | 11.01 | 149 | 310551 | 8581 | 29255246 |
Intervertebral disc displacement | 14.97 | 11.01 | 12 | 310688 | 124 | 29263703 |
Tricuspid valve calcification | 14.94 | 11.01 | 5 | 310695 | 4 | 29263823 |
Lymphoma | 14.91 | 11.01 | 53 | 310647 | 9775 | 29254052 |
Cerebral haemorrhage | 14.87 | 11.01 | 434 | 310266 | 30992 | 29232835 |
Low density lipoprotein decreased | 14.84 | 11.01 | 33 | 310667 | 987 | 29262840 |
Putamen haemorrhage | 14.80 | 11.01 | 15 | 310685 | 215 | 29263612 |
Dyspnoea at rest | 14.80 | 11.01 | 70 | 310630 | 3144 | 29260683 |
Malignant neoplasm progression | 14.71 | 11.01 | 630 | 310070 | 73229 | 29190598 |
Band neutrophil percentage decreased | 14.62 | 11.01 | 6 | 310694 | 13 | 29263814 |
Graft versus host disease in gastrointestinal tract | 14.60 | 11.01 | 8 | 310692 | 3250 | 29260577 |
High density lipoprotein decreased | 14.54 | 11.01 | 66 | 310634 | 2913 | 29260914 |
Atrial septal defect | 14.50 | 11.01 | 31 | 310669 | 6758 | 29257069 |
Blood uric acid increased | 14.44 | 11.01 | 107 | 310593 | 5661 | 29258166 |
Bundle branch block left | 14.43 | 11.01 | 100 | 310600 | 5177 | 29258650 |
Cachexia | 14.40 | 11.01 | 28 | 310672 | 6321 | 29257506 |
Product administered to patient of inappropriate age | 14.30 | 11.01 | 5 | 310695 | 2650 | 29261177 |
Blood pressure abnormal | 14.28 | 11.01 | 121 | 310579 | 6669 | 29257158 |
Mucosal membrane hyperplasia | 14.27 | 11.01 | 4 | 310696 | 0 | 29263827 |
Ventricular compliance decreased | 14.27 | 11.01 | 4 | 310696 | 0 | 29263827 |
Left ventricular enlargement | 14.22 | 11.01 | 25 | 310675 | 627 | 29263200 |
Discomfort | 14.19 | 11.01 | 226 | 310474 | 14537 | 29249290 |
Blood cholinesterase decreased | 14.17 | 11.01 | 11 | 310689 | 108 | 29263719 |
Muscle rigidity | 14.11 | 11.01 | 51 | 310649 | 9360 | 29254467 |
Hepatic enzyme increased | 14.06 | 11.01 | 260 | 310440 | 33539 | 29230288 |
Euphoric mood | 14.06 | 11.01 | 18 | 310682 | 4807 | 29259020 |
Hypospadias | 14.00 | 11.01 | 7 | 310693 | 2995 | 29260832 |
Polypectomy | 13.98 | 11.01 | 22 | 310678 | 502 | 29263325 |
Device leakage | 13.91 | 11.01 | 16 | 310684 | 4479 | 29259348 |
Herpes zoster | 13.84 | 11.01 | 227 | 310473 | 29825 | 29234002 |
Gastric cancer | 13.80 | 11.01 | 92 | 310608 | 4702 | 29259125 |
Lacrimal disorder | 13.79 | 11.01 | 17 | 310683 | 306 | 29263521 |
Body temperature decreased | 13.78 | 11.01 | 172 | 310528 | 10492 | 29253335 |
Blood aldosterone increased | 13.77 | 11.01 | 6 | 310694 | 16 | 29263811 |
Prostate cancer recurrent | 13.76 | 11.01 | 30 | 310670 | 885 | 29262942 |
Encephalitis toxic | 13.72 | 11.01 | 16 | 310684 | 271 | 29263556 |
Giant cell arteritis | 13.63 | 11.01 | 27 | 310673 | 743 | 29263084 |
Crying | 13.58 | 11.01 | 22 | 310678 | 5329 | 29258498 |
Neonatal respiratory distress syndrome | 13.57 | 11.01 | 12 | 310688 | 3798 | 29260029 |
Hepatocellular carcinoma | 13.54 | 11.01 | 123 | 310577 | 6915 | 29256912 |
Thromboangiitis obliterans | 13.51 | 11.01 | 6 | 310694 | 17 | 29263810 |
Unintentional medical device removal | 13.51 | 11.01 | 4 | 310696 | 2357 | 29261470 |
Hypocalcaemia | 13.50 | 11.01 | 298 | 310402 | 20367 | 29243460 |
Post-traumatic amnestic disorder | 13.47 | 11.01 | 8 | 310692 | 48 | 29263779 |
Suspected suicide attempt | 13.46 | 11.01 | 11 | 310689 | 117 | 29263710 |
Cutaneous lupus erythematosus | 13.46 | 11.01 | 26 | 310674 | 702 | 29263125 |
Migraine | 13.45 | 11.01 | 76 | 310624 | 12354 | 29251473 |
Intentional product misuse | 13.39 | 11.01 | 270 | 310430 | 34391 | 29229436 |
Histology abnormal | 13.36 | 11.01 | 16 | 310684 | 279 | 29263548 |
Mitral valve incompetence | 13.35 | 11.01 | 205 | 310495 | 13088 | 29250739 |
Nausea | 13.33 | 11.01 | 2760 | 307940 | 286495 | 28977332 |
Oedema | 13.32 | 11.01 | 536 | 310164 | 39947 | 29223880 |
Allergy to animal | 13.28 | 11.01 | 15 | 310685 | 245 | 29263582 |
Device use error | 13.28 | 11.01 | 3 | 310697 | 2119 | 29261708 |
Product solubility abnormal | 13.27 | 11.01 | 20 | 310680 | 439 | 29263388 |
Toxic nodular goitre | 13.27 | 11.01 | 6 | 310694 | 18 | 29263809 |
Osteoporosis | 13.26 | 11.01 | 63 | 310637 | 10706 | 29253121 |
Dysphagia | 13.24 | 11.01 | 458 | 310242 | 54468 | 29209359 |
Pulmonary valve disease | 13.23 | 11.01 | 16 | 310684 | 282 | 29263545 |
Lipoma | 13.21 | 11.01 | 39 | 310661 | 1392 | 29262435 |
Nodal rhythm | 13.18 | 11.01 | 37 | 310663 | 1283 | 29262544 |
Lymphocyte count decreased | 13.16 | 11.01 | 134 | 310566 | 19137 | 29244690 |
Atrioventricular block second degree | 13.16 | 11.01 | 67 | 310633 | 3101 | 29260726 |
Sex hormone binding globulin increased | 13.14 | 11.01 | 5 | 310695 | 8 | 29263819 |
Generalised oedema | 13.13 | 11.01 | 177 | 310523 | 10988 | 29252839 |
Acute coronary syndrome | 13.13 | 11.01 | 192 | 310508 | 12133 | 29251694 |
Pruritus | 13.12 | 11.01 | 1411 | 309289 | 115438 | 29148389 |
Pelvic cyst | 13.11 | 11.01 | 7 | 310693 | 33 | 29263794 |
Hair colour changes | 13.10 | 11.01 | 42 | 310658 | 1569 | 29262258 |
Bacteraemia | 13.10 | 11.01 | 109 | 310591 | 16214 | 29247613 |
Malaise | 13.10 | 11.01 | 1890 | 308810 | 157712 | 29106115 |
Retinopathy hypertensive | 13.05 | 11.01 | 15 | 310685 | 250 | 29263577 |
Multiple sclerosis | 13.03 | 11.01 | 24 | 310676 | 5530 | 29258297 |
Hepatic function abnormal | 12.96 | 11.01 | 520 | 310180 | 38739 | 29225088 |
Respiratory arrest | 12.96 | 11.01 | 192 | 310508 | 25641 | 29238186 |
Hyperthermia | 12.92 | 11.01 | 53 | 310647 | 9377 | 29254450 |
Injection site reaction | 12.88 | 11.01 | 67 | 310633 | 11121 | 29252706 |
Thrombotic stroke | 12.86 | 11.01 | 15 | 310685 | 254 | 29263573 |
Hyperammonaemia | 12.82 | 11.01 | 25 | 310675 | 5638 | 29258189 |
Nephrogenic systemic fibrosis | 12.80 | 11.01 | 78 | 310622 | 3864 | 29259963 |
Thirst | 12.78 | 11.01 | 114 | 310586 | 6377 | 29257450 |
Guillain-Barre syndrome | 12.76 | 11.01 | 94 | 310606 | 4964 | 29258863 |
Hypertensive encephalopathy | 12.74 | 11.01 | 17 | 310683 | 332 | 29263495 |
Blood urea increased | 12.69 | 11.01 | 386 | 310314 | 27726 | 29236101 |
Low birth weight baby | 12.64 | 11.01 | 32 | 310668 | 6576 | 29257251 |
Aortic aneurysm | 12.64 | 11.01 | 110 | 310590 | 6110 | 29257717 |
Therapy non-responder | 12.48 | 11.01 | 239 | 310461 | 30672 | 29233155 |
Macrophages increased | 12.35 | 11.01 | 12 | 310688 | 163 | 29263664 |
Drug screen positive | 12.34 | 11.01 | 13 | 310687 | 3788 | 29260039 |
Hyperbilirubinaemia | 12.31 | 11.01 | 99 | 310601 | 14835 | 29248992 |
Blood potassium decreased | 12.29 | 11.01 | 233 | 310467 | 15501 | 29248326 |
Urogenital haemorrhage | 12.29 | 11.01 | 20 | 310680 | 470 | 29263357 |
Enterococcal infection | 12.27 | 11.01 | 45 | 310655 | 8223 | 29255604 |
Incorrect route of product administration | 12.26 | 11.01 | 65 | 310635 | 10736 | 29253091 |
Fracture displacement | 12.26 | 11.01 | 8 | 310692 | 58 | 29263769 |
Sinonasal obstruction | 12.19 | 11.01 | 6 | 310694 | 23 | 29263804 |
Thrombotic cerebral infarction | 12.17 | 11.01 | 16 | 310684 | 308 | 29263519 |
Herbal interaction | 12.17 | 11.01 | 16 | 310684 | 308 | 29263519 |
Drug level decreased | 12.15 | 11.01 | 30 | 310670 | 6217 | 29257610 |
Brain contusion | 12.09 | 11.01 | 25 | 310675 | 710 | 29263117 |
Dialysis | 12.07 | 11.01 | 162 | 310538 | 10046 | 29253781 |
Generalised bullous fixed drug eruption | 12.06 | 11.01 | 4 | 310696 | 3 | 29263824 |
Ventricular hyperkinesia | 12.01 | 11.01 | 13 | 310687 | 202 | 29263625 |
Uveitis | 12.01 | 11.01 | 28 | 310672 | 5919 | 29257908 |
Primary hypoparathyroidism | 11.99 | 11.01 | 6 | 310694 | 24 | 29263803 |
Flour sensitivity | 11.99 | 11.01 | 6 | 310694 | 24 | 29263803 |
Lung hernia | 11.93 | 11.01 | 8 | 310692 | 61 | 29263766 |
Body temperature increased | 11.88 | 11.01 | 96 | 310604 | 14369 | 29249458 |
Respiratory failure | 11.87 | 11.01 | 869 | 309831 | 96262 | 29167565 |
Peripheral artery stenosis | 11.87 | 11.01 | 27 | 310673 | 820 | 29263007 |
Helicobacter gastritis | 11.84 | 11.01 | 31 | 310669 | 1031 | 29262796 |
Antipsychotic drug level increased | 11.81 | 11.01 | 10 | 310690 | 3233 | 29260594 |
Peripheral artery occlusion | 11.78 | 11.01 | 38 | 310662 | 1424 | 29262403 |
Renal artery thrombosis | 11.75 | 11.01 | 15 | 310685 | 280 | 29263547 |
Pneumocystis jirovecii pneumonia | 11.74 | 11.01 | 116 | 310584 | 16663 | 29247164 |
Left atrial enlargement | 11.68 | 11.01 | 25 | 310675 | 728 | 29263099 |
Lymphomatoid papulosis | 11.63 | 11.01 | 12 | 310688 | 176 | 29263651 |
Full blood count abnormal | 11.62 | 11.01 | 222 | 310478 | 14791 | 29249036 |
Noninfective gingivitis | 11.61 | 11.01 | 14 | 310686 | 246 | 29263581 |
Therapeutic response decreased | 11.60 | 11.01 | 186 | 310514 | 24525 | 29239302 |
Sinus node dysfunction | 11.57 | 11.01 | 73 | 310627 | 3661 | 29260166 |
Pericarditis uraemic | 11.56 | 11.01 | 5 | 310695 | 13 | 29263814 |
Arterial stenosis | 11.55 | 11.01 | 32 | 310668 | 1101 | 29262726 |
Anxiety | 11.55 | 11.01 | 757 | 309943 | 84608 | 29179219 |
Diffuse large B-cell lymphoma | 11.54 | 11.01 | 31 | 310669 | 6245 | 29257582 |
Forced vital capacity decreased | 11.49 | 11.01 | 23 | 310677 | 638 | 29263189 |
Hepatotoxicity | 11.49 | 11.01 | 126 | 310574 | 17741 | 29246086 |
Drug abuser | 11.44 | 11.01 | 14 | 310686 | 3813 | 29260014 |
Pneumonia cytomegaloviral | 11.43 | 11.01 | 7 | 310693 | 2675 | 29261152 |
Intercepted product preparation error | 11.43 | 11.01 | 5 | 310695 | 2312 | 29261515 |
Lung operation | 11.43 | 11.01 | 8 | 310692 | 66 | 29263761 |
Arteriosclerosis | 11.41 | 11.01 | 161 | 310539 | 10095 | 29253732 |
Prerenal failure | 11.40 | 11.01 | 43 | 310657 | 1745 | 29262082 |
Strongyloidiasis | 11.39 | 11.01 | 5 | 310695 | 2307 | 29261520 |
Gingivitis | 11.38 | 11.01 | 61 | 310639 | 2881 | 29260946 |
Ultrafiltration failure | 11.35 | 11.01 | 11 | 310689 | 149 | 29263678 |
Hypertensive nephropathy | 11.34 | 11.01 | 18 | 310682 | 414 | 29263413 |
Occult blood | 11.34 | 11.01 | 21 | 310679 | 549 | 29263278 |
Red blood cell sedimentation rate abnormal | 11.31 | 11.01 | 5 | 310695 | 2298 | 29261529 |
Yellow skin | 11.31 | 11.01 | 45 | 310655 | 1873 | 29261954 |
Hepatitis | 11.30 | 11.01 | 152 | 310548 | 20631 | 29243196 |
Retinal vascular thrombosis | 11.24 | 11.01 | 8 | 310692 | 68 | 29263759 |
Renal transplant | 11.23 | 11.01 | 40 | 310660 | 1578 | 29262249 |
Brain abscess | 11.22 | 11.01 | 7 | 310693 | 2648 | 29261179 |
Decreased appetite | 11.19 | 11.01 | 1715 | 308985 | 143627 | 29120200 |
Intestinal stenosis | 11.17 | 11.01 | 3 | 310697 | 1885 | 29261942 |
Large intestine polyp | 11.16 | 11.01 | 111 | 310589 | 6398 | 29257429 |
Cytomegalovirus colitis | 11.16 | 11.01 | 6 | 310694 | 2463 | 29261364 |
Osmolar gap abnormal | 11.12 | 11.01 | 6 | 310694 | 29 | 29263798 |
Oliguria | 11.10 | 11.01 | 123 | 310577 | 7289 | 29256538 |
Gastric ulcer haemorrhage | 11.10 | 11.01 | 89 | 310611 | 4825 | 29259002 |
Stasis dermatitis | 11.07 | 11.01 | 24 | 310676 | 705 | 29263122 |
Mean platelet volume increased | 11.06 | 11.01 | 18 | 310682 | 423 | 29263404 |
Mycobacterium avium complex infection | 11.03 | 11.01 | 5 | 310695 | 2264 | 29261563 |
Palatal oedema | 11.03 | 11.01 | 24 | 310676 | 707 | 29263120 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1173.37 | 10.37 | 4577 | 580316 | 219837 | 63694002 |
Drug ineffective | 882.41 | 10.37 | 4277 | 580616 | 835970 | 63077869 |
Hypotension | 672.34 | 10.37 | 5815 | 579078 | 375159 | 63538680 |
Off label use | 650.08 | 10.37 | 3243 | 581650 | 629563 | 63284276 |
Shock | 638.33 | 10.37 | 1201 | 583692 | 37039 | 63876800 |
Gingival hypertrophy | 631.85 | 10.37 | 362 | 584531 | 2385 | 63911454 |
Synovitis | 562.29 | 10.37 | 108 | 584785 | 98982 | 63814857 |
Acute kidney injury | 515.05 | 10.37 | 6278 | 578615 | 442962 | 63470877 |
Maternal exposure during pregnancy | 476.11 | 10.37 | 139 | 584754 | 95745 | 63818094 |
Drug abuse | 455.36 | 10.37 | 322 | 584571 | 132052 | 63781787 |
Treatment failure | 453.26 | 10.37 | 247 | 584646 | 116569 | 63797270 |
Contraindicated product administered | 439.18 | 10.37 | 214 | 584679 | 107615 | 63806224 |
Anti-cyclic citrullinated peptide antibody positive | 431.59 | 10.37 | 3 | 584890 | 49559 | 63864280 |
Non-cardiogenic pulmonary oedema | 425.63 | 10.37 | 217 | 584676 | 1091 | 63912748 |
Drug intolerance | 425.13 | 10.37 | 654 | 584239 | 187338 | 63726501 |
Infusion related reaction | 417.00 | 10.37 | 527 | 584366 | 163940 | 63749899 |
Bradycardia | 410.89 | 10.37 | 2138 | 582755 | 116081 | 63797758 |
Blood pressure inadequately controlled | 408.15 | 10.37 | 360 | 584533 | 5024 | 63908815 |
Hand deformity | 397.84 | 10.37 | 50 | 584843 | 62721 | 63851118 |
Oedema peripheral | 391.05 | 10.37 | 3250 | 581643 | 207067 | 63706772 |
Pemphigus | 385.57 | 10.37 | 48 | 584845 | 60653 | 63853186 |
Systemic lupus erythematosus | 368.29 | 10.37 | 122 | 584771 | 77490 | 63836349 |
Intentional overdose | 364.81 | 10.37 | 1700 | 583193 | 88244 | 63825595 |
Therapeutic product effect decreased | 348.65 | 10.37 | 319 | 584574 | 115032 | 63798807 |
Arthropathy | 345.33 | 10.37 | 352 | 584541 | 120615 | 63793224 |
Hyponatraemia | 316.09 | 10.37 | 2366 | 582527 | 145973 | 63767866 |
Pericarditis | 311.47 | 10.37 | 90 | 584803 | 62426 | 63851413 |
Angioedema | 300.61 | 10.37 | 1234 | 583659 | 60587 | 63853252 |
Rheumatoid arthritis | 298.83 | 10.37 | 653 | 584240 | 163641 | 63750198 |
Cerebrovascular accident | 279.96 | 10.37 | 2171 | 582722 | 135412 | 63778427 |
Glossodynia | 265.52 | 10.37 | 127 | 584766 | 64569 | 63849270 |
Orthostatic hypotension | 263.03 | 10.37 | 977 | 583916 | 45761 | 63868078 |
Blood pressure increased | 261.90 | 10.37 | 2552 | 582341 | 170000 | 63743839 |
Distributive shock | 254.69 | 10.37 | 177 | 584716 | 1698 | 63912141 |
Hypertensive crisis | 245.58 | 10.37 | 524 | 584369 | 17724 | 63896115 |
Rheumatoid factor positive | 244.44 | 10.37 | 19 | 584874 | 34919 | 63878920 |
Hyperkalaemia | 241.38 | 10.37 | 1658 | 583235 | 99471 | 63814368 |
Hepatic enzyme increased | 240.80 | 10.37 | 511 | 584382 | 129432 | 63784407 |
Renal impairment | 240.41 | 10.37 | 2067 | 582826 | 132950 | 63780889 |
Alopecia | 240.34 | 10.37 | 738 | 584155 | 164952 | 63748887 |
Product use in unapproved indication | 237.23 | 10.37 | 814 | 584079 | 175804 | 63738035 |
Fall | 233.21 | 10.37 | 5178 | 579715 | 411648 | 63502191 |
Vasoplegia syndrome | 227.91 | 10.37 | 194 | 584699 | 2573 | 63911266 |
Metabolic acidosis | 221.83 | 10.37 | 1247 | 583646 | 69711 | 63844128 |
Product use issue | 217.72 | 10.37 | 679 | 584214 | 151036 | 63762803 |
Exposure during pregnancy | 216.03 | 10.37 | 231 | 584662 | 77444 | 63836395 |
C-reactive protein abnormal | 214.40 | 10.37 | 12 | 584881 | 29035 | 63884804 |
Hypersensitivity | 212.17 | 10.37 | 987 | 583906 | 195465 | 63718374 |
Sleep disorder due to general medical condition, insomnia type | 203.12 | 10.37 | 8 | 584885 | 26262 | 63887577 |
Lactic acidosis | 201.84 | 10.37 | 1094 | 583799 | 60316 | 63853523 |
Pain | 200.88 | 10.37 | 3673 | 581220 | 549838 | 63364001 |
Syncope | 197.08 | 10.37 | 2242 | 582651 | 155393 | 63758446 |
Neutropenia | 196.13 | 10.37 | 1319 | 583574 | 238305 | 63675534 |
Hypokalaemia | 191.81 | 10.37 | 1817 | 583076 | 120086 | 63793753 |
Helicobacter infection | 189.67 | 10.37 | 56 | 584837 | 38306 | 63875533 |
Febrile neutropenia | 185.82 | 10.37 | 972 | 583921 | 186685 | 63727154 |
Sinusitis | 185.64 | 10.37 | 688 | 584205 | 145240 | 63768599 |
Duodenal ulcer perforation | 185.56 | 10.37 | 43 | 584850 | 34582 | 63879257 |
Wound | 181.56 | 10.37 | 257 | 584636 | 76220 | 63837619 |
Cerebral infarction | 175.40 | 10.37 | 788 | 584105 | 40256 | 63873583 |
Folliculitis | 172.23 | 10.37 | 32 | 584861 | 30045 | 63883794 |
Blood creatinine increased | 170.50 | 10.37 | 1933 | 582960 | 133849 | 63779990 |
Cardiac failure congestive | 167.62 | 10.37 | 1867 | 583026 | 128713 | 63785126 |
Hypoglycaemia | 162.99 | 10.37 | 1382 | 583511 | 88510 | 63825329 |
Dizziness | 162.97 | 10.37 | 5077 | 579816 | 425086 | 63488753 |
Rhabdomyolysis | 156.30 | 10.37 | 1391 | 583502 | 90335 | 63823504 |
Arthralgia | 155.50 | 10.37 | 2950 | 581943 | 439310 | 63474529 |
Infection | 146.09 | 10.37 | 1028 | 583865 | 183852 | 63729987 |
Angina pectoris | 142.69 | 10.37 | 795 | 584098 | 44286 | 63869553 |
Injection site pain | 139.87 | 10.37 | 528 | 584365 | 110880 | 63802959 |
Muscle injury | 139.37 | 10.37 | 34 | 584859 | 26403 | 63887436 |
Therapeutic product effect incomplete | 138.14 | 10.37 | 478 | 584415 | 103004 | 63810835 |
Abortion spontaneous | 137.19 | 10.37 | 30 | 584863 | 25113 | 63888726 |
Swollen tongue | 136.03 | 10.37 | 653 | 584240 | 34301 | 63879538 |
Condition aggravated | 134.30 | 10.37 | 2473 | 582420 | 369953 | 63543886 |
Injection site erythema | 131.46 | 10.37 | 278 | 584615 | 70522 | 63843317 |
Pregnancy | 128.89 | 10.37 | 18 | 584875 | 20847 | 63892992 |
Myocardial infarction | 128.56 | 10.37 | 2166 | 582727 | 163655 | 63750184 |
Musculoskeletal stiffness | 127.68 | 10.37 | 628 | 584265 | 122578 | 63791261 |
Pyrexia | 126.51 | 10.37 | 3981 | 580912 | 554663 | 63359176 |
Red blood cell sedimentation rate abnormal | 125.95 | 10.37 | 5 | 584888 | 16301 | 63897538 |
Irritable bowel syndrome | 123.11 | 10.37 | 95 | 584798 | 37274 | 63876565 |
Chronic kidney disease | 116.61 | 10.37 | 912 | 583981 | 57007 | 63856832 |
Device expulsion | 115.77 | 10.37 | 25 | 584868 | 21111 | 63892728 |
Renal failure | 114.89 | 10.37 | 2299 | 582594 | 179389 | 63734450 |
Atrioventricular block complete | 114.76 | 10.37 | 339 | 584554 | 14079 | 63899760 |
Drug resistance | 114.67 | 10.37 | 90 | 584803 | 35012 | 63878827 |
Injection site reaction | 113.56 | 10.37 | 154 | 584739 | 46510 | 63867329 |
Overdose | 113.18 | 10.37 | 2055 | 582838 | 157511 | 63756328 |
Impaired healing | 108.50 | 10.37 | 242 | 584651 | 60231 | 63853608 |
Discomfort | 106.99 | 10.37 | 375 | 584518 | 80503 | 63833336 |
Lower respiratory tract infection | 104.64 | 10.37 | 471 | 584422 | 94143 | 63819696 |
Coronary artery disease | 104.24 | 10.37 | 919 | 583974 | 59514 | 63854325 |
Suicide attempt | 104.08 | 10.37 | 1043 | 583850 | 69964 | 63843875 |
Intentional product use issue | 102.34 | 10.37 | 480 | 584413 | 94884 | 63818955 |
Creatinine renal clearance decreased | 98.95 | 10.37 | 322 | 584571 | 14099 | 63899740 |
Cardiogenic shock | 98.75 | 10.37 | 566 | 584327 | 31861 | 63881978 |
Sinus bradycardia | 98.16 | 10.37 | 440 | 584453 | 22453 | 63891386 |
Abdominal discomfort | 97.77 | 10.37 | 1119 | 583774 | 181203 | 63732636 |
Atrial fibrillation | 97.75 | 10.37 | 2133 | 582760 | 168956 | 63744883 |
Pulmonary oedema | 97.34 | 10.37 | 1117 | 583776 | 77557 | 63836282 |
Neurologic neglect syndrome | 97.13 | 10.37 | 95 | 584798 | 1523 | 63912316 |
Toxicity to various agents | 94.48 | 10.37 | 4114 | 580779 | 359399 | 63554440 |
Stomatitis | 94.28 | 10.37 | 594 | 584299 | 109011 | 63804828 |
Hypomagnesaemia | 92.82 | 10.37 | 619 | 584274 | 36757 | 63877082 |
Swelling | 91.61 | 10.37 | 969 | 583924 | 159249 | 63754590 |
Drug dependence | 91.57 | 10.37 | 100 | 584793 | 33212 | 63880627 |
Atrioventricular block first degree | 89.88 | 10.37 | 257 | 584636 | 10477 | 63903362 |
Suspected suicide | 89.44 | 10.37 | 224 | 584669 | 8430 | 63905409 |
Blood pressure systolic increased | 87.35 | 10.37 | 756 | 584137 | 48697 | 63865142 |
Depressed level of consciousness | 87.17 | 10.37 | 1125 | 583768 | 80311 | 63833528 |
Proteinuria | 87.12 | 10.37 | 488 | 584405 | 27235 | 63886604 |
Fibromyalgia | 86.86 | 10.37 | 118 | 584775 | 35613 | 63878226 |
Joint swelling | 84.93 | 10.37 | 1407 | 583486 | 213975 | 63699864 |
Sedation complication | 83.89 | 10.37 | 245 | 584648 | 10109 | 63903730 |
Carotid artery thrombosis | 81.90 | 10.37 | 91 | 584802 | 1704 | 63912135 |
Hypertensive emergency | 81.62 | 10.37 | 102 | 584791 | 2174 | 63911665 |
Acute myocardial infarction | 81.43 | 10.37 | 979 | 583914 | 68739 | 63845100 |
Psoriatic arthropathy | 81.13 | 10.37 | 169 | 584724 | 43112 | 63870727 |
Lip swelling | 79.58 | 10.37 | 529 | 584364 | 31378 | 63882461 |
Balance disorder | 79.01 | 10.37 | 1133 | 583760 | 82793 | 63831046 |
Wrong technique in product usage process | 78.91 | 10.37 | 312 | 584581 | 64662 | 63849177 |
Pemphigoid | 78.58 | 10.37 | 278 | 584615 | 12708 | 63901131 |
Decreased appetite | 76.74 | 10.37 | 3200 | 581693 | 278089 | 63635750 |
Migraine | 76.74 | 10.37 | 300 | 584593 | 62377 | 63851462 |
Anuria | 76.49 | 10.37 | 358 | 584535 | 18606 | 63895233 |
Live birth | 75.88 | 10.37 | 7 | 584886 | 11197 | 63902642 |
Renin increased | 75.33 | 10.37 | 38 | 584855 | 186 | 63913653 |
Ill-defined disorder | 75.23 | 10.37 | 181 | 584712 | 43871 | 63869968 |
Rash | 74.87 | 10.37 | 3397 | 581496 | 455152 | 63458687 |
Pathogen resistance | 72.56 | 10.37 | 13 | 584880 | 12530 | 63901309 |
Intentional self-injury | 71.53 | 10.37 | 95 | 584798 | 28949 | 63884890 |
Renal artery stenosis | 70.35 | 10.37 | 109 | 584784 | 2860 | 63910979 |
Transient ischaemic attack | 70.14 | 10.37 | 660 | 584233 | 43522 | 63870317 |
Injection site pruritus | 69.81 | 10.37 | 149 | 584744 | 37677 | 63876162 |
Infective pulmonary exacerbation of cystic fibrosis | 68.73 | 10.37 | 12 | 584881 | 11784 | 63902055 |
Hypertension | 68.13 | 10.37 | 2938 | 581955 | 256323 | 63657516 |
Hyperglycaemia | 68.11 | 10.37 | 849 | 584044 | 60119 | 63853720 |
Injection site swelling | 67.43 | 10.37 | 174 | 584719 | 41179 | 63872660 |
Septic shock | 66.37 | 10.37 | 623 | 584270 | 104814 | 63809025 |
Weight increased | 65.87 | 10.37 | 1453 | 583440 | 211895 | 63701944 |
Diabetes mellitus inadequate control | 65.47 | 10.37 | 373 | 584520 | 20948 | 63892891 |
Rheumatoid nodule | 65.27 | 10.37 | 17 | 584876 | 12634 | 63901205 |
Sprue-like enteropathy | 64.75 | 10.37 | 62 | 584831 | 967 | 63912872 |
Drug interaction | 64.24 | 10.37 | 3952 | 580941 | 358131 | 63555708 |
Chronic pigmented purpura | 64.03 | 10.37 | 32 | 584861 | 153 | 63913686 |
Immune reconstitution inflammatory syndrome | 63.88 | 10.37 | 17 | 584876 | 12453 | 63901386 |
Gastrointestinal disorder | 63.59 | 10.37 | 514 | 584379 | 89195 | 63824644 |
Cytomegalovirus infection | 62.61 | 10.37 | 154 | 584739 | 37045 | 63876794 |
Asthenia | 61.80 | 10.37 | 4592 | 580301 | 423452 | 63490387 |
Gingival swelling | 61.55 | 10.37 | 120 | 584773 | 3800 | 63910039 |
Thrombocytopenia | 61.38 | 10.37 | 1552 | 583341 | 222249 | 63691590 |
Injection site bruising | 60.89 | 10.37 | 151 | 584742 | 36222 | 63877617 |
Carotid artery stenosis | 59.70 | 10.37 | 183 | 584710 | 7758 | 63906081 |
Loss of consciousness | 59.40 | 10.37 | 1764 | 583129 | 146601 | 63767238 |
Glycosylated haemoglobin increased | 59.27 | 10.37 | 295 | 584598 | 15724 | 63898115 |
Dyspnoea | 59.24 | 10.37 | 7410 | 577483 | 711264 | 63202575 |
Tenosynovitis | 58.99 | 10.37 | 17 | 584876 | 11816 | 63902023 |
Leukopenia | 58.37 | 10.37 | 611 | 584282 | 100631 | 63813208 |
Hemiplegia | 58.23 | 10.37 | 250 | 584643 | 12518 | 63901321 |
Gingival bleeding | 58.15 | 10.37 | 278 | 584615 | 14576 | 63899263 |
Mucosal inflammation | 57.57 | 10.37 | 332 | 584561 | 62252 | 63851587 |
Product monitoring error | 57.23 | 10.37 | 142 | 584751 | 5312 | 63908527 |
Bone marrow failure | 57.12 | 10.37 | 232 | 584661 | 47720 | 63866119 |
Aortic dissection | 57.06 | 10.37 | 108 | 584785 | 3344 | 63910495 |
Atrioventricular block | 56.93 | 10.37 | 238 | 584655 | 11777 | 63902062 |
Myocardial depression | 55.81 | 10.37 | 42 | 584851 | 461 | 63913378 |
Left ventricular hypertrophy | 55.38 | 10.37 | 201 | 584692 | 9305 | 63904534 |
Blood calcium decreased | 55.13 | 10.37 | 409 | 584484 | 25145 | 63888694 |
Melaena | 54.89 | 10.37 | 734 | 584159 | 52814 | 63861025 |
Nasopharyngitis | 54.76 | 10.37 | 1356 | 583537 | 194717 | 63719122 |
Blood pressure decreased | 54.51 | 10.37 | 1091 | 583802 | 85108 | 63828731 |
Blood creatine phosphokinase increased | 54.10 | 10.37 | 788 | 584105 | 57770 | 63856069 |
Myelosuppression | 53.69 | 10.37 | 83 | 584810 | 23747 | 63890092 |
Product prescribing error | 53.58 | 10.37 | 522 | 584371 | 34747 | 63879092 |
Palpitations | 53.50 | 10.37 | 1283 | 583610 | 103205 | 63810634 |
Haematotoxicity | 53.38 | 10.37 | 25 | 584868 | 12871 | 63900968 |
Body temperature increased | 52.61 | 10.37 | 164 | 584729 | 36502 | 63877337 |
Circulatory collapse | 52.60 | 10.37 | 502 | 584391 | 33230 | 63880609 |
Acute graft versus host disease | 49.23 | 10.37 | 11 | 584882 | 9073 | 63904766 |
Angina unstable | 49.09 | 10.37 | 273 | 584620 | 15194 | 63898645 |
Myalgia | 48.93 | 10.37 | 1829 | 583064 | 156788 | 63757051 |
Bone erosion | 48.74 | 10.37 | 22 | 584871 | 11573 | 63902266 |
Injection site warmth | 48.59 | 10.37 | 31 | 584862 | 13431 | 63900408 |
Immunodeficiency | 48.20 | 10.37 | 45 | 584848 | 16079 | 63897760 |
Nocturia | 48.17 | 10.37 | 215 | 584678 | 10950 | 63902889 |
Hyperdynamic left ventricle | 48.01 | 10.37 | 31 | 584862 | 260 | 63913579 |
Interstitial lung disease | 47.62 | 10.37 | 1192 | 583701 | 96540 | 63817299 |
Hypertensive heart disease | 47.50 | 10.37 | 106 | 584787 | 3698 | 63910141 |
Oliguria | 47.41 | 10.37 | 259 | 584634 | 14317 | 63899522 |
Multiple sclerosis relapse | 47.15 | 10.37 | 202 | 584691 | 40933 | 63872906 |
Renal cell carcinoma | 47.14 | 10.37 | 142 | 584751 | 5962 | 63907877 |
Blood urea increased | 46.83 | 10.37 | 609 | 584284 | 43544 | 63870295 |
Adjustment disorder | 46.76 | 10.37 | 87 | 584806 | 2658 | 63911181 |
Pseudolymphoma | 46.66 | 10.37 | 52 | 584841 | 977 | 63912862 |
Hip arthroplasty | 46.56 | 10.37 | 76 | 584817 | 21275 | 63892564 |
Hepatic function abnormal | 46.51 | 10.37 | 831 | 584062 | 63482 | 63850357 |
Nephrotic syndrome | 46.50 | 10.37 | 191 | 584702 | 9376 | 63904463 |
Aggression | 45.96 | 10.37 | 239 | 584654 | 45993 | 63867846 |
Lacunar infarction | 45.88 | 10.37 | 132 | 584761 | 5400 | 63908439 |
Subacute cutaneous lupus erythematosus | 45.56 | 10.37 | 91 | 584802 | 2934 | 63910905 |
Post transplant lymphoproliferative disorder | 45.26 | 10.37 | 15 | 584878 | 9529 | 63904310 |
Aspergillus infection | 45.20 | 10.37 | 49 | 584844 | 16330 | 63897509 |
Foot deformity | 44.85 | 10.37 | 50 | 584843 | 16454 | 63897385 |
Therapeutic response decreased | 44.77 | 10.37 | 283 | 584610 | 51905 | 63861934 |
Hyperlipidaemia | 44.70 | 10.37 | 359 | 584534 | 22617 | 63891222 |
Cytokine release syndrome | 44.62 | 10.37 | 75 | 584818 | 20754 | 63893085 |
Renal disorder | 44.57 | 10.37 | 504 | 584389 | 34861 | 63878978 |
Ear infection | 44.19 | 10.37 | 91 | 584802 | 23313 | 63890526 |
Haemorrhage subcutaneous | 44.15 | 10.37 | 112 | 584781 | 4249 | 63909590 |
Haematochezia | 43.96 | 10.37 | 846 | 584047 | 65527 | 63848312 |
Nodal rhythm | 43.94 | 10.37 | 87 | 584806 | 2787 | 63911052 |
Loss of personal independence in daily activities | 43.94 | 10.37 | 432 | 584461 | 72022 | 63841817 |
Hepatotoxicity | 43.53 | 10.37 | 200 | 584693 | 39762 | 63874077 |
Dehydration | 42.98 | 10.37 | 2390 | 582503 | 214373 | 63699466 |
Haemophagocytic lymphohistiocytosis | 42.95 | 10.37 | 58 | 584835 | 17551 | 63896288 |
Blood glucose increased | 42.82 | 10.37 | 1179 | 583714 | 96894 | 63816945 |
Personality disorder | 42.60 | 10.37 | 116 | 584777 | 4595 | 63909244 |
Cardiac failure | 42.18 | 10.37 | 1532 | 583361 | 130841 | 63782998 |
Mydriasis | 42.04 | 10.37 | 46 | 584847 | 15266 | 63898573 |
Device issue | 41.97 | 10.37 | 89 | 584804 | 22559 | 63891280 |
Dysarthria | 41.69 | 10.37 | 764 | 584129 | 58642 | 63855197 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 41.46 | 10.37 | 86 | 584807 | 2850 | 63910989 |
Blood potassium decreased | 41.09 | 10.37 | 553 | 584340 | 39846 | 63873993 |
Acute hepatic failure | 40.95 | 10.37 | 112 | 584781 | 26000 | 63887839 |
Eating disorder | 40.93 | 10.37 | 277 | 584616 | 16528 | 63897311 |
Graft versus host disease | 40.76 | 10.37 | 39 | 584854 | 13774 | 63900065 |
Hypocalcaemia | 40.62 | 10.37 | 567 | 584326 | 41186 | 63872653 |
Haemodynamic instability | 40.10 | 10.37 | 252 | 584641 | 14660 | 63899179 |
Disability | 40.02 | 10.37 | 31 | 584862 | 12141 | 63901698 |
Agitation | 40 | 10.37 | 562 | 584331 | 87805 | 63826034 |
Chronic graft versus host disease | 39.75 | 10.37 | 5 | 584888 | 6271 | 63907568 |
Erectile dysfunction | 39.49 | 10.37 | 222 | 584671 | 12405 | 63901434 |
Caesarean section | 39.29 | 10.37 | 27 | 584866 | 11247 | 63902592 |
Neurotoxicity | 39.02 | 10.37 | 123 | 584770 | 27281 | 63886558 |
Haemodialysis | 38.95 | 10.37 | 277 | 584616 | 16800 | 63897039 |
5-hydroxyindolacetic acid in urine increased | 38.79 | 10.37 | 25 | 584868 | 209 | 63913630 |
Progressive multifocal leukoencephalopathy | 38.73 | 10.37 | 66 | 584827 | 18166 | 63895673 |
BRASH syndrome | 38.58 | 10.37 | 30 | 584863 | 347 | 63913492 |
Atrioventricular block second degree | 38.05 | 10.37 | 137 | 584756 | 6317 | 63907522 |
Urticaria | 37.88 | 10.37 | 1031 | 583862 | 146286 | 63767553 |
Therapy partial responder | 37.82 | 10.37 | 23 | 584870 | 10225 | 63903614 |
Periodontitis | 37.20 | 10.37 | 102 | 584791 | 4057 | 63909782 |
Hypoinsulinaemia | 37.12 | 10.37 | 10 | 584883 | 0 | 63913839 |
Multiple-drug resistance | 37.05 | 10.37 | 7 | 584886 | 6495 | 63907344 |
Product substitution issue | 36.91 | 10.37 | 283 | 584610 | 17578 | 63896261 |
Inappropriate antidiuretic hormone secretion | 36.91 | 10.37 | 336 | 584557 | 21953 | 63891886 |
Carotid arteriosclerosis | 36.81 | 10.37 | 67 | 584826 | 2012 | 63911827 |
Unintentional medical device removal | 36.81 | 10.37 | 8 | 584885 | 6726 | 63907113 |
Faeces discoloured | 36.76 | 10.37 | 376 | 584517 | 25353 | 63888486 |
Diabetic nephropathy | 36.62 | 10.37 | 77 | 584816 | 2577 | 63911262 |
Prescription drug used without a prescription | 36.53 | 10.37 | 76 | 584817 | 2524 | 63911315 |
Thalamus haemorrhage | 36.37 | 10.37 | 58 | 584835 | 1561 | 63912278 |
Chest pain | 36.27 | 10.37 | 2545 | 582348 | 233435 | 63680404 |
Osteoporosis | 36.19 | 10.37 | 228 | 584665 | 41852 | 63871987 |
Glomerulonephritis rapidly progressive | 36.11 | 10.37 | 52 | 584841 | 1276 | 63912563 |
Irritability | 35.94 | 10.37 | 191 | 584702 | 36555 | 63877284 |
Device adhesion issue | 35.77 | 10.37 | 3 | 584890 | 5183 | 63908656 |
Hyperuricaemia | 35.13 | 10.37 | 184 | 584709 | 10007 | 63903832 |
Seizure | 35.05 | 10.37 | 1200 | 583693 | 165692 | 63748147 |
Hepatocellular carcinoma | 34.90 | 10.37 | 160 | 584733 | 8243 | 63905596 |
Hemiparesis | 34.88 | 10.37 | 419 | 584474 | 29408 | 63884431 |
Arteriosclerosis | 34.75 | 10.37 | 255 | 584638 | 15622 | 63898217 |
Anaemia | 34.70 | 10.37 | 3932 | 580961 | 374748 | 63539091 |
Metastatic renal cell carcinoma | 34.21 | 10.37 | 67 | 584826 | 2129 | 63911710 |
Substance abuse | 34.09 | 10.37 | 21 | 584872 | 9271 | 63904568 |
Status epilepticus | 33.91 | 10.37 | 93 | 584800 | 21570 | 63892269 |
Acute myeloid leukaemia | 33.90 | 10.37 | 131 | 584762 | 27332 | 63886507 |
Ovarian cyst | 33.83 | 10.37 | 30 | 584863 | 10988 | 63902851 |
Hyperaldosteronism | 33.72 | 10.37 | 28 | 584865 | 358 | 63913481 |
Glomerular filtration rate decreased | 33.41 | 10.37 | 297 | 584596 | 19275 | 63894564 |
Staphylococcal infection | 33.37 | 10.37 | 296 | 584597 | 50382 | 63863457 |
Cardiomegaly | 33.30 | 10.37 | 345 | 584548 | 23339 | 63890500 |
Oedema | 33.30 | 10.37 | 1080 | 583813 | 90855 | 63822984 |
Drug withdrawal syndrome | 33.26 | 10.37 | 158 | 584735 | 31133 | 63882706 |
Diastolic dysfunction | 33.23 | 10.37 | 164 | 584729 | 8711 | 63905128 |
Linear IgA disease | 33.19 | 10.37 | 76 | 584817 | 2698 | 63911141 |
Drug tolerance decreased | 33.19 | 10.37 | 11 | 584882 | 6987 | 63906852 |
Febrile bone marrow aplasia | 32.95 | 10.37 | 32 | 584861 | 11223 | 63902616 |
Urine output decreased | 32.80 | 10.37 | 259 | 584634 | 16233 | 63897606 |
Tongue oedema | 32.67 | 10.37 | 124 | 584769 | 5866 | 63907973 |
Pancytopenia | 32.56 | 10.37 | 1020 | 583873 | 142289 | 63771550 |
Allergic reaction to excipient | 32.39 | 10.37 | 23 | 584870 | 229 | 63913610 |
Malaise | 32.29 | 10.37 | 4084 | 580809 | 392163 | 63521676 |
Lymphocyte count decreased | 32.25 | 10.37 | 226 | 584667 | 40473 | 63873366 |
Nephrosclerosis | 32.20 | 10.37 | 54 | 584839 | 1517 | 63912322 |
Psychotic disorder | 32.03 | 10.37 | 183 | 584710 | 34395 | 63879444 |
Cerebral haemorrhage | 31.74 | 10.37 | 645 | 584248 | 50445 | 63863394 |
Uterine perforation | 31.64 | 10.37 | 7 | 584886 | 5813 | 63908026 |
Presyncope | 31.55 | 10.37 | 470 | 584423 | 34619 | 63879220 |
Dyspnoea exertional | 31.51 | 10.37 | 884 | 584009 | 72846 | 63840993 |
Ischaemic stroke | 31.43 | 10.37 | 402 | 584491 | 28633 | 63885206 |
Primary hyperaldosteronism | 31.36 | 10.37 | 18 | 584875 | 119 | 63913720 |
Peripheral arterial occlusive disease | 31.24 | 10.37 | 136 | 584757 | 6851 | 63906988 |
Palmar-plantar erythrodysaesthesia syndrome | 31.19 | 10.37 | 399 | 584494 | 28420 | 63885419 |
Vasodilatation | 31.06 | 10.37 | 78 | 584815 | 2940 | 63910899 |
Dystonia | 31.04 | 10.37 | 79 | 584814 | 18786 | 63895053 |
Drug ineffective for unapproved indication | 30.91 | 10.37 | 161 | 584732 | 30972 | 63882867 |
Generalised oedema | 30.88 | 10.37 | 307 | 584586 | 20546 | 63893293 |
Gastric ulcer haemorrhage | 30.86 | 10.37 | 151 | 584742 | 7992 | 63905847 |
Lymphadenopathy | 30.60 | 10.37 | 273 | 584620 | 46413 | 63867426 |
Pollakiuria | 30.60 | 10.37 | 428 | 584465 | 31102 | 63882737 |
Bronchopulmonary aspergillosis | 30.58 | 10.37 | 81 | 584812 | 19004 | 63894835 |
Bundle branch block right | 30.45 | 10.37 | 178 | 584715 | 10091 | 63903748 |
Altered state of consciousness | 30.02 | 10.37 | 497 | 584396 | 37405 | 63876434 |
Venoocclusive liver disease | 29.88 | 10.37 | 28 | 584865 | 9987 | 63903852 |
Injection site haemorrhage | 29.84 | 10.37 | 116 | 584777 | 24162 | 63889677 |
Swelling face | 29.82 | 10.37 | 725 | 584168 | 58441 | 63855398 |
Premature labour | 29.70 | 10.37 | 16 | 584877 | 7604 | 63906235 |
Mitral valve incompetence | 29.54 | 10.37 | 358 | 584535 | 25180 | 63888659 |
Acute coronary syndrome | 29.43 | 10.37 | 286 | 584607 | 19024 | 63894815 |
Gastrointestinal tract mucosal pigmentation | 29.26 | 10.37 | 39 | 584854 | 888 | 63912951 |
Fatigue | 29.22 | 10.37 | 6173 | 578720 | 742557 | 63171282 |
Injection site urticaria | 29.17 | 10.37 | 35 | 584858 | 11146 | 63902693 |
Haematemesis | 29.08 | 10.37 | 593 | 584300 | 46406 | 63867433 |
Ischaemia | 29.06 | 10.37 | 137 | 584756 | 7141 | 63906698 |
Diabetic neuropathy | 28.96 | 10.37 | 114 | 584779 | 5487 | 63908352 |
Gout | 28.74 | 10.37 | 309 | 584584 | 21104 | 63892735 |
Panniculitis | 28.70 | 10.37 | 23 | 584870 | 8856 | 63904983 |
Tubulointerstitial nephritis | 28.57 | 10.37 | 416 | 584477 | 30493 | 63883346 |
Knee arthroplasty | 28.30 | 10.37 | 137 | 584756 | 26862 | 63886977 |
Gingivitis | 28.30 | 10.37 | 141 | 584752 | 7518 | 63906321 |
Blood aldosterone increased | 28.26 | 10.37 | 20 | 584873 | 198 | 63913641 |
Disease recurrence | 28.00 | 10.37 | 169 | 584724 | 31341 | 63882498 |
Cytomegalovirus infection reactivation | 27.38 | 10.37 | 9 | 584884 | 5747 | 63908092 |
Heavy menstrual bleeding | 27.27 | 10.37 | 42 | 584851 | 12035 | 63901804 |
Bladder irritation | 27.22 | 10.37 | 20 | 584873 | 211 | 63913628 |
Adenovirus infection | 27.17 | 10.37 | 16 | 584877 | 7239 | 63906600 |
Myelodysplastic syndrome | 27.17 | 10.37 | 143 | 584750 | 27436 | 63886403 |
Herpes zoster | 27.15 | 10.37 | 530 | 584363 | 78657 | 63835182 |
Blood mercury abnormal | 26.86 | 10.37 | 19 | 584874 | 188 | 63913651 |
Metastases to bone | 26.84 | 10.37 | 95 | 584798 | 20340 | 63893499 |
Hypervolaemia | 26.73 | 10.37 | 492 | 584401 | 37793 | 63876046 |
Aphasia | 26.61 | 10.37 | 520 | 584373 | 40386 | 63873453 |
Blood parathyroid hormone decreased | 26.54 | 10.37 | 17 | 584876 | 7349 | 63906490 |
Blood uric acid increased | 26.52 | 10.37 | 145 | 584748 | 8018 | 63905821 |
Gastric cancer | 26.50 | 10.37 | 123 | 584770 | 6370 | 63907469 |
Myocardial ischaemia | 26.48 | 10.37 | 325 | 584568 | 22926 | 63890913 |
Blood lactic acid increased | 26.27 | 10.37 | 173 | 584720 | 10228 | 63903611 |
Carotid sinus syndrome | 26.26 | 10.37 | 12 | 584881 | 45 | 63913794 |
Accelerated hypertension | 26.09 | 10.37 | 30 | 584863 | 584 | 63913255 |
Device use error | 26.09 | 10.37 | 13 | 584880 | 6458 | 63907381 |
Graft versus host disease in skin | 26.08 | 10.37 | 8 | 584885 | 5339 | 63908500 |
Thirst | 25.95 | 10.37 | 218 | 584675 | 13919 | 63899920 |
Venoocclusive disease | 25.67 | 10.37 | 3 | 584890 | 3982 | 63909857 |
Upper respiratory tract infection | 25.61 | 10.37 | 485 | 584408 | 72300 | 63841539 |
Skin toxicity | 25.53 | 10.37 | 14 | 584879 | 6588 | 63907251 |
Eczema | 25.52 | 10.37 | 395 | 584498 | 29325 | 63884514 |
Prostatic specific antigen increased | 25.43 | 10.37 | 151 | 584742 | 8609 | 63905230 |
Premature delivery | 25.38 | 10.37 | 85 | 584808 | 18504 | 63895335 |
Drug hypersensitivity | 25.35 | 10.37 | 1835 | 583058 | 235980 | 63677859 |
Sepsis | 25.26 | 10.37 | 1773 | 583120 | 228568 | 63685271 |
Mucormycosis | 25.03 | 10.37 | 18 | 584875 | 7323 | 63906516 |
Sinus arrest | 24.92 | 10.37 | 73 | 584820 | 3017 | 63910822 |
Accidental exposure to product | 24.70 | 10.37 | 139 | 584754 | 26225 | 63887614 |
Nodule | 24.54 | 10.37 | 82 | 584811 | 17865 | 63895974 |
Hypoperfusion | 24.53 | 10.37 | 61 | 584832 | 2285 | 63911554 |
Red blood cell sedimentation rate increased | 24.47 | 10.37 | 174 | 584719 | 31061 | 63882778 |
Putamen haemorrhage | 24.35 | 10.37 | 25 | 584868 | 426 | 63913413 |
Enthesopathy | 24.27 | 10.37 | 31 | 584862 | 9607 | 63904232 |
Sickle cell anaemia with crisis | 24.22 | 10.37 | 9 | 584884 | 5323 | 63908516 |
Brain stem infarction | 24.12 | 10.37 | 52 | 584841 | 1771 | 63912068 |
Hypertensive encephalopathy | 24.12 | 10.37 | 35 | 584858 | 865 | 63912974 |
Pulmonary renal syndrome | 24.12 | 10.37 | 28 | 584865 | 551 | 63913288 |
Abortion induced | 24.05 | 10.37 | 14 | 584879 | 6374 | 63907465 |
Dialysis | 24.04 | 10.37 | 247 | 584646 | 16673 | 63897166 |
Anaphylactic reaction | 24.02 | 10.37 | 458 | 584435 | 68206 | 63845633 |
Fibromuscular dysplasia | 23.96 | 10.37 | 18 | 584875 | 197 | 63913642 |
Orbital myositis | 23.95 | 10.37 | 16 | 584877 | 143 | 63913696 |
Serotonin syndrome | 23.90 | 10.37 | 234 | 584659 | 39048 | 63874791 |
Foetal death | 23.78 | 10.37 | 12 | 584881 | 5918 | 63907921 |
Lung diffusion test abnormal | 23.77 | 10.37 | 16 | 584877 | 145 | 63913694 |
Candida infection | 23.67 | 10.37 | 177 | 584716 | 31242 | 63882597 |
Device dislocation | 23.66 | 10.37 | 105 | 584788 | 21073 | 63892766 |
Fear of injection | 23.65 | 10.37 | 12 | 584881 | 5900 | 63907939 |
Adverse drug reaction | 23.57 | 10.37 | 281 | 584612 | 45183 | 63868656 |
Respiratory depression | 23.40 | 10.37 | 121 | 584772 | 23322 | 63890517 |
Supraventricular extrasystoles | 23.37 | 10.37 | 111 | 584782 | 5804 | 63908035 |
Granuloma skin | 23.31 | 10.37 | 13 | 584880 | 6061 | 63907778 |
Plasmapheresis | 23.31 | 10.37 | 28 | 584865 | 572 | 63913267 |
Ageusia | 23.26 | 10.37 | 209 | 584684 | 13604 | 63900235 |
Arrhythmia | 23.25 | 10.37 | 637 | 584256 | 52307 | 63861532 |
Drug use disorder | 23.17 | 10.37 | 13 | 584880 | 6041 | 63907798 |
Device difficult to use | 23.17 | 10.37 | 33 | 584860 | 9765 | 63904074 |
Lymphocele | 23.10 | 10.37 | 48 | 584845 | 1593 | 63912246 |
Medication error | 23.03 | 10.37 | 605 | 584288 | 49361 | 63864478 |
Yellow skin | 22.91 | 10.37 | 71 | 584822 | 3028 | 63910811 |
Hepatojugular reflux | 22.82 | 10.37 | 26 | 584867 | 501 | 63913338 |
Myopathy | 22.75 | 10.37 | 253 | 584640 | 17427 | 63896412 |
Flushing | 22.73 | 10.37 | 541 | 584352 | 78107 | 63835732 |
Blood cholinesterase decreased | 22.68 | 10.37 | 18 | 584875 | 215 | 63913624 |
Ischaemic cardiomyopathy | 22.58 | 10.37 | 122 | 584771 | 6716 | 63907123 |
Epstein-Barr virus infection | 22.37 | 10.37 | 50 | 584843 | 12438 | 63901401 |
Alcohol abuse | 22.36 | 10.37 | 8 | 584885 | 4844 | 63908995 |
Heart rate decreased | 22.36 | 10.37 | 656 | 584237 | 54411 | 63859428 |
Duodenal ulcer haemorrhage | 22.36 | 10.37 | 115 | 584778 | 6210 | 63907629 |
Injection site rash | 22.17 | 10.37 | 71 | 584822 | 15671 | 63898168 |
Fungal infection | 22.13 | 10.37 | 201 | 584692 | 34050 | 63879789 |
Cognitive disorder | 22.03 | 10.37 | 655 | 584238 | 54432 | 63859407 |
Ventricular hypertrophy | 22.02 | 10.37 | 117 | 584776 | 6399 | 63907440 |
Hypovolaemic shock | 21.96 | 10.37 | 164 | 584729 | 10102 | 63903737 |
Pericardial effusion | 21.94 | 10.37 | 488 | 584405 | 38766 | 63875073 |
Affect lability | 21.78 | 10.37 | 148 | 584745 | 8842 | 63904997 |
Disease progression | 21.75 | 10.37 | 1056 | 583837 | 140624 | 63773215 |
Joint effusion | 21.72 | 10.37 | 57 | 584836 | 13416 | 63900423 |
Multiple sclerosis | 21.71 | 10.37 | 93 | 584800 | 18848 | 63894991 |
Large intestine polyp | 21.45 | 10.37 | 170 | 584723 | 10667 | 63903172 |
Hyperplasia | 21.38 | 10.37 | 37 | 584856 | 1067 | 63912772 |
Lymphocyte stimulation test positive | 21.33 | 10.37 | 37 | 584856 | 1069 | 63912770 |
Osteopenia | 21.25 | 10.37 | 71 | 584822 | 15469 | 63898370 |
Tendonitis | 21.21 | 10.37 | 103 | 584790 | 20179 | 63893660 |
Red blood cell sedimentation rate | 21.16 | 10.37 | 4 | 584889 | 3710 | 63910129 |
Suicidal ideation | 21.13 | 10.37 | 451 | 584442 | 66091 | 63847748 |
Coma | 21.02 | 10.37 | 619 | 584274 | 86996 | 63826843 |
Scleral discolouration | 20.96 | 10.37 | 25 | 584868 | 507 | 63913332 |
Human herpesvirus 6 infection | 20.90 | 10.37 | 8 | 584885 | 4646 | 63909193 |
Blood glucose decreased | 20.89 | 10.37 | 310 | 584583 | 22813 | 63891026 |
Labile hypertension | 20.88 | 10.37 | 25 | 584868 | 509 | 63913330 |
Joint destruction | 20.54 | 10.37 | 4 | 584889 | 3632 | 63910207 |
Liver carcinoma ruptured | 20.51 | 10.37 | 15 | 584878 | 157 | 63913682 |
Varicella zoster virus infection | 20.49 | 10.37 | 5 | 584888 | 3883 | 63909956 |
Blister | 20.45 | 10.37 | 568 | 584325 | 80399 | 63833440 |
Low density lipoprotein decreased | 20.42 | 10.37 | 36 | 584857 | 1054 | 63912785 |
Cardiovascular disorder | 20.31 | 10.37 | 227 | 584666 | 15654 | 63898185 |
Congenital hiatus hernia | 20.31 | 10.37 | 22 | 584871 | 400 | 63913439 |
Bundle branch block left | 20.19 | 10.37 | 158 | 584735 | 9876 | 63903963 |
Urine albumin/creatinine ratio increased | 20.09 | 10.37 | 20 | 584873 | 328 | 63913511 |
Gestational diabetes | 20.00 | 10.37 | 13 | 584880 | 5577 | 63908262 |
Blood potassium increased | 19.96 | 10.37 | 339 | 584554 | 25641 | 63888198 |
Hypergastrinaemia | 19.90 | 10.37 | 15 | 584878 | 165 | 63913674 |
Diabetes mellitus | 19.88 | 10.37 | 764 | 584129 | 65710 | 63848129 |
Diverticulum intestinal haemorrhagic | 19.79 | 10.37 | 70 | 584823 | 3199 | 63910640 |
Forced vital capacity decreased | 19.78 | 10.37 | 43 | 584850 | 1473 | 63912366 |
Ear pain | 19.71 | 10.37 | 140 | 584753 | 24996 | 63888843 |
Lipodystrophy acquired | 19.68 | 10.37 | 6 | 584887 | 4021 | 63909818 |
Viral infection | 19.66 | 10.37 | 221 | 584672 | 35919 | 63877920 |
Nipple inflammation | 19.66 | 10.37 | 10 | 584883 | 50 | 63913789 |
Ocular icterus | 19.66 | 10.37 | 95 | 584798 | 5003 | 63908836 |
Rales | 19.63 | 10.37 | 218 | 584675 | 15011 | 63898828 |
Cytomegalovirus chorioretinitis | 19.61 | 10.37 | 10 | 584883 | 4902 | 63908937 |
Hepatic neoplasm | 19.59 | 10.37 | 67 | 584826 | 3010 | 63910829 |
Product dose omission issue | 19.58 | 10.37 | 1510 | 583383 | 193237 | 63720602 |
Polypectomy | 19.53 | 10.37 | 33 | 584860 | 933 | 63912906 |
Inflammation | 19.47 | 10.37 | 447 | 584446 | 64853 | 63848986 |
Sinus node dysfunction | 19.38 | 10.37 | 117 | 584776 | 6711 | 63907128 |
Mycobacterium marinum infection | 19.37 | 10.37 | 21 | 584872 | 382 | 63913457 |
Temperature regulation disorder | 19.31 | 10.37 | 7 | 584886 | 4204 | 63909635 |
Lichen nitidus | 19.26 | 10.37 | 11 | 584882 | 72 | 63913767 |
Diabetic retinopathy | 19.13 | 10.37 | 63 | 584830 | 2776 | 63911063 |
Gravitational oedema | 19.12 | 10.37 | 45 | 584848 | 1627 | 63912212 |
Polymyositis | 19.03 | 10.37 | 61 | 584832 | 2649 | 63911190 |
Headache | 19.02 | 10.37 | 4382 | 580511 | 525085 | 63388754 |
Renal transplant | 18.99 | 10.37 | 54 | 584839 | 2194 | 63911645 |
Bundle branch block | 18.97 | 10.37 | 41 | 584852 | 1399 | 63912440 |
Peripheral artery stenosis | 18.97 | 10.37 | 37 | 584856 | 1172 | 63912667 |
Gastrointestinal haemorrhage | 18.94 | 10.37 | 1419 | 583474 | 130893 | 63782946 |
Left ventricular enlargement | 18.92 | 10.37 | 27 | 584866 | 657 | 63913182 |
Cytomegalovirus viraemia | 18.87 | 10.37 | 44 | 584849 | 10784 | 63903055 |
Uveitis | 18.83 | 10.37 | 56 | 584837 | 12652 | 63901187 |
Skin tightness | 18.81 | 10.37 | 92 | 584801 | 4869 | 63908970 |
Epiglottic oedema | 18.77 | 10.37 | 17 | 584876 | 246 | 63913593 |
Kidney transplant rejection | 18.71 | 10.37 | 149 | 584744 | 9362 | 63904477 |
Subdural haematoma | 18.71 | 10.37 | 358 | 584535 | 27696 | 63886143 |
Unintended pregnancy | 18.68 | 10.37 | 3 | 584890 | 3131 | 63910708 |
Prerenal failure | 18.66 | 10.37 | 68 | 584825 | 3154 | 63910685 |
Tricuspid valve incompetence | 18.65 | 10.37 | 236 | 584657 | 16767 | 63897072 |
Hypersensitivity vasculitis | 18.65 | 10.37 | 115 | 584778 | 6646 | 63907193 |
Prostate cancer recurrent | 18.57 | 10.37 | 28 | 584865 | 717 | 63913122 |
Mucosal membrane hyperplasia | 18.52 | 10.37 | 9 | 584884 | 40 | 63913799 |
Coeliac disease | 18.50 | 10.37 | 24 | 584869 | 7388 | 63906451 |
Injection site discolouration | 18.50 | 10.37 | 21 | 584872 | 6854 | 63906985 |
Zoonotic bacterial infection | 18.48 | 10.37 | 10 | 584883 | 58 | 63913781 |
Dry eye | 18.45 | 10.37 | 171 | 584722 | 28848 | 63884991 |
Blood loss anaemia | 18.43 | 10.37 | 200 | 584693 | 13692 | 63900147 |
Bladder sphincter atony | 18.36 | 10.37 | 12 | 584881 | 103 | 63913736 |
CD30 expression | 18.35 | 10.37 | 9 | 584884 | 41 | 63913798 |
Coordination abnormal | 18.29 | 10.37 | 212 | 584681 | 14752 | 63899087 |
Ventricular hyperkinesia | 18.23 | 10.37 | 17 | 584876 | 256 | 63913583 |
Enterochromaffin cell hyperplasia | 18.20 | 10.37 | 11 | 584882 | 81 | 63913758 |
Chondroma | 18.17 | 10.37 | 6 | 584887 | 6 | 63913833 |
Vaginal haemorrhage | 18.12 | 10.37 | 102 | 584791 | 19242 | 63894597 |
Pulse abnormal | 17.93 | 10.37 | 59 | 584834 | 2598 | 63911241 |
Breath sounds abnormal | 17.86 | 10.37 | 173 | 584720 | 11496 | 63902343 |
Fibrillary glomerulonephritis | 17.85 | 10.37 | 9 | 584884 | 44 | 63913795 |
Generalised tonic-clonic seizure | 17.85 | 10.37 | 254 | 584639 | 39603 | 63874236 |
Portal hypertension | 17.84 | 10.37 | 18 | 584875 | 6201 | 63907638 |
Dermatomyositis | 17.78 | 10.37 | 61 | 584832 | 2745 | 63911094 |
Dyslalia | 17.77 | 10.37 | 32 | 584861 | 953 | 63912886 |
C-reactive protein increased | 17.75 | 10.37 | 692 | 584201 | 94217 | 63819622 |
Sensory loss | 17.71 | 10.37 | 155 | 584738 | 10014 | 63903825 |
Dyskinesia | 17.64 | 10.37 | 251 | 584642 | 39137 | 63874702 |
Cholecystitis chronic | 17.62 | 10.37 | 36 | 584857 | 9251 | 63904588 |
Drug abuser | 17.61 | 10.37 | 16 | 584877 | 5792 | 63908047 |
Neovascularisation | 17.60 | 10.37 | 34 | 584859 | 1069 | 63912770 |
Graft versus host disease in gastrointestinal tract | 17.57 | 10.37 | 15 | 584878 | 5597 | 63908242 |
Carcinoid tumour | 17.56 | 10.37 | 21 | 584872 | 427 | 63913412 |
Premature rupture of membranes | 17.55 | 10.37 | 6 | 584887 | 3738 | 63910101 |
Cardiac disorder | 17.52 | 10.37 | 645 | 584248 | 55171 | 63858668 |
Atrioventricular dissociation | 17.52 | 10.37 | 18 | 584875 | 307 | 63913532 |
Atheroembolism | 17.48 | 10.37 | 16 | 584877 | 235 | 63913604 |
Nephrogenic systemic fibrosis | 17.39 | 10.37 | 102 | 584791 | 5790 | 63908049 |
Electrocardiogram Q wave abnormal | 17.37 | 10.37 | 20 | 584873 | 390 | 63913449 |
Chromaturia | 17.36 | 10.37 | 295 | 584598 | 22316 | 63891523 |
Cerebellar haemorrhage | 17.30 | 10.37 | 58 | 584835 | 2579 | 63911260 |
Chronic obstructive pulmonary disease | 17.27 | 10.37 | 799 | 584094 | 70249 | 63843590 |
Embolic stroke | 17.18 | 10.37 | 112 | 584781 | 6599 | 63907240 |
Arterial occlusive disease | 17.17 | 10.37 | 116 | 584777 | 6917 | 63906922 |
Lethargy | 17.13 | 10.37 | 814 | 584079 | 71780 | 63842059 |
Clear cell renal cell carcinoma | 17.12 | 10.37 | 51 | 584842 | 2128 | 63911711 |
Traumatic haemorrhage | 17.11 | 10.37 | 34 | 584859 | 1092 | 63912747 |
Ulcer | 17.09 | 10.37 | 130 | 584763 | 22860 | 63890979 |
Dilatation ventricular | 17.05 | 10.37 | 75 | 584818 | 3795 | 63910044 |
Drug tolerance | 17.02 | 10.37 | 18 | 584875 | 6067 | 63907772 |
Pulmonary hypoplasia | 16.94 | 10.37 | 9 | 584884 | 50 | 63913789 |
Gastrointestinal toxicity | 16.94 | 10.37 | 14 | 584879 | 5308 | 63908531 |
Pulmonary valve disease | 16.84 | 10.37 | 16 | 584877 | 247 | 63913592 |
Breast cancer stage III | 16.83 | 10.37 | 3 | 584890 | 2902 | 63910937 |
Urinary retention | 16.79 | 10.37 | 574 | 584319 | 48627 | 63865212 |
Retinopathy hypertensive | 16.75 | 10.37 | 21 | 584872 | 449 | 63913390 |
Gingival pain | 16.75 | 10.37 | 107 | 584786 | 6260 | 63907579 |
Fine motor skill dysfunction | 16.72 | 10.37 | 11 | 584882 | 4688 | 63909151 |
Schizophrenia | 16.70 | 10.37 | 49 | 584844 | 11119 | 63902720 |
Left atrial enlargement | 16.70 | 10.37 | 32 | 584861 | 1000 | 63912839 |
Cardiac dysfunction | 16.70 | 10.37 | 64 | 584829 | 3042 | 63910797 |
Bradyarrhythmia | 16.69 | 10.37 | 73 | 584820 | 3685 | 63910154 |
Herpes simplex | 16.66 | 10.37 | 45 | 584848 | 10491 | 63903348 |
Intestinal ischaemia | 16.60 | 10.37 | 169 | 584724 | 11380 | 63902459 |
Paranoia | 16.55 | 10.37 | 84 | 584809 | 16268 | 63897571 |
Dislocation of vertebra | 16.50 | 10.37 | 4 | 584889 | 3120 | 63910719 |
Sensitivity to weather change | 16.49 | 10.37 | 22 | 584871 | 6692 | 63907147 |
Hypoglossal nerve paralysis | 16.47 | 10.37 | 7 | 584886 | 21 | 63913818 |
Normal newborn | 16.41 | 10.37 | 16 | 584877 | 5601 | 63908238 |
Harlequin syndrome | 16.39 | 10.37 | 9 | 584884 | 54 | 63913785 |
End stage renal disease | 16.38 | 10.37 | 156 | 584737 | 10319 | 63903520 |
Type I hypersensitivity | 16.29 | 10.37 | 6 | 584887 | 3568 | 63910271 |
Sinoatrial block | 16.29 | 10.37 | 34 | 584859 | 1132 | 63912707 |
Tuberculosis | 16.21 | 10.37 | 62 | 584831 | 12976 | 63900863 |
Aortic aneurysm | 16.21 | 10.37 | 121 | 584772 | 7453 | 63906386 |
Obsessive-compulsive disorder | 16.19 | 10.37 | 12 | 584881 | 4806 | 63909033 |
Gangrene | 16.14 | 10.37 | 118 | 584775 | 7220 | 63906619 |
Pleural effusion | 16.10 | 10.37 | 1345 | 583548 | 125214 | 63788625 |
Finger deformity | 16.07 | 10.37 | 14 | 584879 | 5172 | 63908667 |
Product administered to patient of inappropriate age | 16.06 | 10.37 | 11 | 584882 | 4590 | 63909249 |
Suspected suicide attempt | 16.04 | 10.37 | 16 | 584877 | 263 | 63913576 |
Device related infection | 15.99 | 10.37 | 189 | 584704 | 30437 | 63883402 |
Drug screen positive | 15.96 | 10.37 | 17 | 584876 | 5712 | 63908127 |
Hyperparathyroidism secondary | 15.96 | 10.37 | 52 | 584841 | 2278 | 63911561 |
Abnormal behaviour | 15.87 | 10.37 | 212 | 584681 | 33410 | 63880429 |
Protein urine present | 15.85 | 10.37 | 137 | 584756 | 8819 | 63905020 |
Pseudomonas infection | 15.84 | 10.37 | 96 | 584797 | 17787 | 63896052 |
Dyspnoea at rest | 15.82 | 10.37 | 105 | 584788 | 6224 | 63907615 |
Gallbladder adenocarcinoma | 15.79 | 10.37 | 11 | 584882 | 106 | 63913733 |
Grip strength decreased | 15.74 | 10.37 | 54 | 584839 | 11670 | 63902169 |
Joint stiffness | 15.73 | 10.37 | 188 | 584705 | 30216 | 63883623 |
Femoral neck fracture | 15.73 | 10.37 | 134 | 584759 | 8590 | 63905249 |
Stenosis | 15.73 | 10.37 | 44 | 584849 | 1771 | 63912068 |
Device leakage | 15.72 | 10.37 | 32 | 584861 | 8234 | 63905605 |
Neoplasm progression | 15.66 | 10.37 | 269 | 584624 | 40695 | 63873144 |
Tricuspid valve calcification | 15.66 | 10.37 | 5 | 584888 | 4 | 63913835 |
Azotaemia | 15.57 | 10.37 | 119 | 584774 | 7383 | 63906456 |
Rectal ulcer haemorrhage | 15.56 | 10.37 | 15 | 584878 | 236 | 63913603 |
Nasal crusting | 15.55 | 10.37 | 22 | 584871 | 531 | 63913308 |
Deafness neurosensory | 15.54 | 10.37 | 21 | 584872 | 6353 | 63907486 |
Alanine aminotransferase abnormal | 15.51 | 10.37 | 24 | 584869 | 6864 | 63906975 |
Band neutrophil percentage decreased | 15.47 | 10.37 | 6 | 584887 | 13 | 63913826 |
Dermatitis infected | 15.44 | 10.37 | 14 | 584879 | 203 | 63913636 |
Incorrect route of product administration | 15.37 | 10.37 | 136 | 584757 | 23162 | 63890677 |
Galactorrhoea | 15.37 | 10.37 | 5 | 584888 | 3214 | 63910625 |
Intestinal villi atrophy | 15.28 | 10.37 | 18 | 584875 | 360 | 63913479 |
Cystic fibrosis | 15.26 | 10.37 | 6 | 584887 | 3428 | 63910411 |
Duodenal ulcer | 15.26 | 10.37 | 199 | 584694 | 14236 | 63899603 |
Blood pressure abnormal | 15.26 | 10.37 | 199 | 584694 | 14236 | 63899603 |
Mitochondrial toxicity | 15.23 | 10.37 | 3 | 584890 | 2703 | 63911136 |
Renal injury | 15.20 | 10.37 | 210 | 584683 | 15219 | 63898620 |
Pericardial haemorrhage | 15.18 | 10.37 | 76 | 584817 | 4060 | 63909779 |
Neuroleptic malignant syndrome | 15.16 | 10.37 | 149 | 584744 | 24847 | 63888992 |
Purpura | 15.11 | 10.37 | 230 | 584663 | 17016 | 63896823 |
Transplant rejection | 15.11 | 10.37 | 94 | 584799 | 17307 | 63896532 |
Diffuse large B-cell lymphoma | 15.11 | 10.37 | 46 | 584847 | 10315 | 63903524 |
Micturition urgency | 15.09 | 10.37 | 152 | 584741 | 10207 | 63903632 |
Nephrogenic anaemia | 15.08 | 10.37 | 65 | 584828 | 3260 | 63910579 |
Adenoma benign | 15.07 | 10.37 | 31 | 584862 | 1021 | 63912818 |
Constipation | 15.01 | 10.37 | 2334 | 582559 | 227003 | 63686836 |
Body tinea | 15.00 | 10.37 | 35 | 584858 | 1258 | 63912581 |
Metabolic alkalosis | 15.00 | 10.37 | 73 | 584820 | 3855 | 63909984 |
Glucose tolerance impaired | 14.98 | 10.37 | 105 | 584788 | 6338 | 63907501 |
Intestinal angioedema | 14.97 | 10.37 | 27 | 584866 | 805 | 63913034 |
Complication of device insertion | 14.97 | 10.37 | 14 | 584879 | 4998 | 63908841 |
Peripheral artery occlusion | 14.90 | 10.37 | 48 | 584845 | 2090 | 63911749 |
Hypothermia | 14.86 | 10.37 | 258 | 584635 | 19598 | 63894241 |
Ventricular compliance decreased | 14.85 | 10.37 | 4 | 584889 | 0 | 63913839 |
Sinonasal obstruction | 14.82 | 10.37 | 13 | 584880 | 180 | 63913659 |
Idiopathic pulmonary fibrosis | 14.79 | 10.37 | 71 | 584822 | 3729 | 63910110 |
Mean arterial pressure decreased | 14.74 | 10.37 | 17 | 584876 | 332 | 63913507 |
Hepatosplenomegaly | 14.73 | 10.37 | 16 | 584877 | 5327 | 63908512 |
Hepatic failure | 14.66 | 10.37 | 386 | 584507 | 55008 | 63858831 |
Benign neoplasm of adrenal gland | 14.60 | 10.37 | 7 | 584886 | 30 | 63913809 |
Death | 14.60 | 10.37 | 4026 | 580867 | 478679 | 63435160 |
Glucose urine present | 14.57 | 10.37 | 40 | 584853 | 1592 | 63912247 |
Hyperthermia | 14.56 | 10.37 | 82 | 584811 | 15468 | 63898371 |
Synovial cyst | 14.52 | 10.37 | 30 | 584863 | 7677 | 63906162 |
Amenorrhoea | 14.52 | 10.37 | 23 | 584870 | 6516 | 63907323 |
Osteonecrosis | 14.43 | 10.37 | 175 | 584718 | 28054 | 63885785 |
Gastric pH increased | 14.43 | 10.37 | 8 | 584885 | 49 | 63913790 |
Upper gastrointestinal haemorrhage | 14.41 | 10.37 | 420 | 584473 | 34800 | 63879039 |
Acute graft versus host disease in skin | 14.39 | 10.37 | 25 | 584868 | 6830 | 63907009 |
Product label on wrong product | 14.36 | 10.37 | 6 | 584887 | 17 | 63913822 |
Immune-mediated myositis | 14.25 | 10.37 | 55 | 584838 | 2623 | 63911216 |
Sex hormone binding globulin increased | 14.25 | 10.37 | 5 | 584888 | 7 | 63913832 |
Device deployment issue | 14.20 | 10.37 | 4 | 584889 | 2822 | 63911017 |
Neuropathy peripheral | 14.15 | 10.37 | 897 | 583996 | 116628 | 63797211 |
Klebsiella infection | 14.15 | 10.37 | 67 | 584826 | 13214 | 63900625 |
Device breakage | 14.15 | 10.37 | 37 | 584856 | 8718 | 63905121 |
Sexual dysfunction | 14.14 | 10.37 | 23 | 584870 | 6448 | 63907391 |
Hypertonic bladder | 14.13 | 10.37 | 65 | 584828 | 3353 | 63910486 |
Gingival disorder | 14.13 | 10.37 | 64 | 584829 | 3280 | 63910559 |
Dysgeusia | 14.13 | 10.37 | 541 | 584352 | 46506 | 63867333 |
Pericardial disease | 14.09 | 10.37 | 20 | 584873 | 484 | 63913355 |
Immunosuppression | 14.09 | 10.37 | 50 | 584843 | 10696 | 63903143 |
Muscle necrosis | 14.08 | 10.37 | 33 | 584860 | 1190 | 63912649 |
Pelvi-ureteric obstruction | 14.05 | 10.37 | 8 | 584885 | 52 | 63913787 |
Glomerulonephritis acute | 14.04 | 10.37 | 12 | 584881 | 160 | 63913679 |
Dermatosis | 14.03 | 10.37 | 20 | 584873 | 486 | 63913353 |
Blood parathyroid hormone increased | 14.01 | 10.37 | 61 | 584832 | 3073 | 63910766 |
Base excess decreased | 13.98 | 10.37 | 17 | 584876 | 352 | 63913487 |
Foetal exposure during pregnancy | 13.97 | 10.37 | 12 | 584881 | 4464 | 63909375 |
Vasculitis | 13.86 | 10.37 | 236 | 584657 | 17859 | 63895980 |
Hyperprolactinaemia | 13.82 | 10.37 | 10 | 584883 | 4055 | 63909784 |
Toxic nodular goitre | 13.76 | 10.37 | 7 | 584886 | 35 | 63913804 |
Pulmonary embolism | 13.75 | 10.37 | 1141 | 583752 | 145215 | 63768624 |
Wrong patient received product | 13.72 | 10.37 | 69 | 584824 | 3693 | 63910146 |
Product storage error | 13.72 | 10.37 | 68 | 584825 | 13250 | 63900589 |
Encephalitis toxic | 13.70 | 10.37 | 15 | 584878 | 276 | 63913563 |
Drug level below therapeutic | 13.69 | 10.37 | 29 | 584864 | 7355 | 63906484 |
Zinc deficiency | 13.69 | 10.37 | 8 | 584885 | 55 | 63913784 |
Faecal calprotectin increased | 13.67 | 10.37 | 8 | 584885 | 3632 | 63910207 |
Genital haemorrhage | 13.66 | 10.37 | 18 | 584875 | 5504 | 63908335 |
Colon cancer | 13.63 | 10.37 | 176 | 584717 | 12563 | 63901276 |
Guillain-Barre syndrome | 13.62 | 10.37 | 117 | 584776 | 7518 | 63906321 |
Osteoarthritis | 13.61 | 10.37 | 454 | 584439 | 62882 | 63850957 |
Cellulitis of male external genital organ | 13.60 | 10.37 | 7 | 584886 | 36 | 63913803 |
Autoimmune enteropathy | 13.60 | 10.37 | 7 | 584886 | 36 | 63913803 |
Enterococcal infection | 13.60 | 10.37 | 72 | 584821 | 13794 | 63900045 |
Arthritis | 13.59 | 10.37 | 621 | 584272 | 83193 | 63830646 |
Essential hypertension | 13.49 | 10.37 | 87 | 584806 | 5107 | 63908732 |
Nipple disorder | 13.46 | 10.37 | 12 | 584881 | 170 | 63913669 |
Femoral artery dissection | 13.45 | 10.37 | 7 | 584886 | 37 | 63913802 |
Tongue disorder | 13.43 | 10.37 | 60 | 584833 | 12020 | 63901819 |
Neuroendocrine tumour | 13.36 | 10.37 | 31 | 584862 | 1110 | 63912729 |
Angiopathy | 13.36 | 10.37 | 100 | 584793 | 6165 | 63907674 |
Hypertensive urgency | 13.35 | 10.37 | 16 | 584877 | 326 | 63913513 |
Haemoglobin decreased | 13.32 | 10.37 | 1990 | 582903 | 193073 | 63720766 |
Blood sodium decreased | 13.31 | 10.37 | 356 | 584537 | 29126 | 63884713 |
Eyelid oedema | 13.28 | 10.37 | 170 | 584723 | 12109 | 63901730 |
Aortic stenosis | 13.23 | 10.37 | 101 | 584792 | 6264 | 63907575 |
Cross sensitivity reaction | 13.22 | 10.37 | 7 | 584886 | 3360 | 63910479 |
Listless | 13.19 | 10.37 | 62 | 584831 | 3228 | 63910611 |
Skin necrosis | 13.18 | 10.37 | 76 | 584817 | 14253 | 63899586 |
Renovascular hypertension | 13.16 | 10.37 | 7 | 584886 | 39 | 63913800 |
Therapy non-responder | 13.09 | 10.37 | 477 | 584416 | 65422 | 63848417 |
Cell marker increased | 13.07 | 10.37 | 22 | 584871 | 620 | 63913219 |
Myositis | 13.06 | 10.37 | 215 | 584678 | 16162 | 63897677 |
Hyperplastic cholecystopathy | 13.05 | 10.37 | 10 | 584883 | 113 | 63913726 |
Lung hernia | 13.01 | 10.37 | 8 | 584885 | 61 | 63913778 |
Hypertensive cardiomyopathy | 13.01 | 10.37 | 15 | 584878 | 293 | 63913546 |
Microalbuminuria | 13.00 | 10.37 | 26 | 584867 | 839 | 63913000 |
Motor dysfunction | 12.96 | 10.37 | 159 | 584734 | 11214 | 63902625 |
Breast cancer | 12.96 | 10.37 | 186 | 584707 | 28962 | 63884877 |
Cardiac myxoma | 12.91 | 10.37 | 10 | 584883 | 115 | 63913724 |
Coronary artery surgery | 12.91 | 10.37 | 12 | 584881 | 180 | 63913659 |
Continuous haemodiafiltration | 12.89 | 10.37 | 43 | 584850 | 1907 | 63911932 |
Acute pulmonary oedema | 12.88 | 10.37 | 175 | 584718 | 12634 | 63901205 |
Accidental death | 12.88 | 10.37 | 9 | 584884 | 3716 | 63910123 |
White blood cell count decreased | 12.86 | 10.37 | 1244 | 583649 | 156593 | 63757246 |
Colitis ulcerative | 12.85 | 10.37 | 140 | 584753 | 22888 | 63890951 |
Carcinoid tumour of the stomach | 12.80 | 10.37 | 12 | 584881 | 182 | 63913657 |
Chills | 12.76 | 10.37 | 1071 | 583822 | 136193 | 63777646 |
Multiple organ dysfunction syndrome | 12.74 | 10.37 | 771 | 584122 | 100642 | 63813197 |
Coronary artery stenosis | 12.71 | 10.37 | 157 | 584736 | 11091 | 63902748 |
Drug level increased | 12.71 | 10.37 | 403 | 584490 | 33793 | 63880046 |
Disturbance in social behaviour | 12.65 | 10.37 | 10 | 584883 | 3877 | 63909962 |
Blood cholinesterase increased | 12.65 | 10.37 | 6 | 584887 | 25 | 63913814 |
Taste disorder | 12.60 | 10.37 | 136 | 584757 | 9297 | 63904542 |
Injury | 12.59 | 10.37 | 399 | 584494 | 55593 | 63858246 |
Multiple drug therapy | 12.58 | 10.37 | 47 | 584846 | 2207 | 63911632 |
Pericarditis uraemic | 12.55 | 10.37 | 5 | 584888 | 12 | 63913827 |
Acidosis | 12.53 | 10.37 | 229 | 584664 | 17566 | 63896273 |
Hallucination, gustatory | 12.50 | 10.37 | 8 | 584885 | 66 | 63913773 |
Acute motor-sensory axonal neuropathy | 12.49 | 10.37 | 17 | 584876 | 395 | 63913444 |
Toxic skin eruption | 12.49 | 10.37 | 245 | 584648 | 19039 | 63894800 |
Stent placement | 12.49 | 10.37 | 90 | 584803 | 5481 | 63908358 |
Pleuritic pain | 12.49 | 10.37 | 35 | 584858 | 8061 | 63905778 |
Abnormal loss of weight | 12.48 | 10.37 | 112 | 584781 | 7288 | 63906551 |
Leukaemoid reaction | 12.47 | 10.37 | 15 | 584878 | 307 | 63913532 |
Leukaemia recurrent | 12.44 | 10.37 | 4 | 584889 | 2590 | 63911249 |
Rhinovirus infection | 12.43 | 10.37 | 23 | 584870 | 6133 | 63907706 |
Inappropriate schedule of product administration | 12.42 | 10.37 | 697 | 584196 | 91589 | 63822250 |
Urine flow decreased | 12.32 | 10.37 | 28 | 584865 | 989 | 63912850 |
Tachycardia | 12.31 | 10.37 | 1178 | 583715 | 148401 | 63765438 |
Hypertensive nephropathy | 12.31 | 10.37 | 25 | 584868 | 816 | 63913023 |
Primary hypoparathyroidism | 12.29 | 10.37 | 6 | 584887 | 27 | 63913812 |
Fulminant type 1 diabetes mellitus | 12.28 | 10.37 | 29 | 584864 | 1051 | 63912788 |
Venous oxygen saturation decreased | 12.27 | 10.37 | 5 | 584888 | 13 | 63913826 |
Gynaecomastia | 12.25 | 10.37 | 95 | 584798 | 5921 | 63907918 |
Macrophages increased | 12.24 | 10.37 | 12 | 584881 | 193 | 63913646 |
Renal artery occlusion | 12.23 | 10.37 | 10 | 584883 | 125 | 63913714 |
Coronary arterial stent insertion | 12.22 | 10.37 | 91 | 584802 | 5601 | 63908238 |
Blood urea abnormal | 12.20 | 10.37 | 31 | 584862 | 1177 | 63912662 |
Nephropathy | 12.19 | 10.37 | 123 | 584770 | 8263 | 63905576 |
Beta 2 microglobulin urine increased | 12.16 | 10.37 | 10 | 584883 | 126 | 63913713 |
Adverse event | 12.15 | 10.37 | 269 | 584624 | 39220 | 63874619 |
Periarticular disorder | 12.12 | 10.37 | 6 | 584887 | 28 | 63913811 |
Cerebral ischaemia | 12.11 | 10.37 | 141 | 584752 | 9821 | 63904018 |
Pleural mass | 12.11 | 10.37 | 8 | 584885 | 70 | 63913769 |
Venous aneurysm | 12.11 | 10.37 | 4 | 584889 | 4 | 63913835 |
Vagus nerve disorder | 12.11 | 10.37 | 7 | 584886 | 47 | 63913792 |
Exposure via ingestion | 12.06 | 10.37 | 81 | 584812 | 4821 | 63909018 |
Hypertensive angiopathy | 12.02 | 10.37 | 9 | 584884 | 98 | 63913741 |
Transaminases increased | 12.00 | 10.37 | 310 | 584583 | 44284 | 63869555 |
Depression | 11.96 | 10.37 | 1467 | 583426 | 181824 | 63732015 |
Optic nerve injury | 11.95 | 10.37 | 20 | 584873 | 561 | 63913278 |
Norepinephrine increased | 11.93 | 10.37 | 8 | 584885 | 72 | 63913767 |
Phaeochromocytoma malignant | 11.93 | 10.37 | 8 | 584885 | 72 | 63913767 |
Gingival atrophy | 11.93 | 10.37 | 8 | 584885 | 72 | 63913767 |
Thrombotic cerebral infarction | 11.85 | 10.37 | 18 | 584875 | 464 | 63913375 |
Peripheral coldness | 11.84 | 10.37 | 181 | 584712 | 13403 | 63900436 |
Bursitis | 11.84 | 10.37 | 131 | 584762 | 21354 | 63892485 |
Tardive dyskinesia | 11.83 | 10.37 | 43 | 584850 | 9135 | 63904704 |
Carbohydrate metabolism disorder | 11.79 | 10.37 | 6 | 584887 | 30 | 63913809 |
Fistula | 11.77 | 10.37 | 47 | 584846 | 9714 | 63904125 |
Psychogenic visual disorder | 11.77 | 10.37 | 5 | 584888 | 15 | 63913824 |
Cytomegalovirus colitis | 11.70 | 10.37 | 11 | 584882 | 3917 | 63909922 |
Intraventricular haemorrhage | 11.68 | 10.37 | 71 | 584822 | 4082 | 63909757 |
Physical examination abnormal | 11.68 | 10.37 | 13 | 584880 | 244 | 63913595 |
Intentional product misuse | 11.65 | 10.37 | 536 | 584357 | 71759 | 63842080 |
Cardiac valve sclerosis | 11.65 | 10.37 | 9 | 584884 | 103 | 63913736 |
Bromhidrosis | 11.65 | 10.37 | 4 | 584889 | 5 | 63913834 |
Lichenification | 11.65 | 10.37 | 22 | 584871 | 680 | 63913159 |
Pelvic cyst | 11.65 | 10.37 | 7 | 584886 | 51 | 63913788 |
Post-traumatic amnestic disorder | 11.65 | 10.37 | 7 | 584886 | 51 | 63913788 |
Brain oedema | 11.61 | 10.37 | 136 | 584757 | 21939 | 63891900 |
Device malfunction | 11.60 | 10.37 | 103 | 584790 | 17530 | 63896309 |
Pharyngitis streptococcal | 11.58 | 10.37 | 40 | 584853 | 8628 | 63905211 |
Aphthous ulcer | 11.58 | 10.37 | 69 | 584824 | 12837 | 63901002 |
Psychomotor hyperactivity | 11.57 | 10.37 | 80 | 584813 | 14371 | 63899468 |
Oral discharge | 11.55 | 10.37 | 13 | 584880 | 247 | 63913592 |
Loose tooth | 11.55 | 10.37 | 55 | 584838 | 2879 | 63910960 |
Surfactant protein increased | 11.53 | 10.37 | 5 | 584888 | 16 | 63913823 |
Muscle spasms | 11.51 | 10.37 | 1454 | 583439 | 139569 | 63774270 |
Henoch-Schonlein purpura | 11.49 | 10.37 | 45 | 584848 | 2161 | 63911678 |
Pulmonary alveolar haemorrhage | 11.47 | 10.37 | 137 | 584756 | 9601 | 63904238 |
Anorexia nervosa | 11.47 | 10.37 | 11 | 584882 | 172 | 63913667 |
Jaundice | 11.45 | 10.37 | 544 | 584349 | 47968 | 63865871 |
Oropharyngeal pain | 11.45 | 10.37 | 674 | 584219 | 88193 | 63825646 |
Interstitial granulomatous dermatitis | 11.44 | 10.37 | 12 | 584881 | 210 | 63913629 |
Intermenstrual bleeding | 11.40 | 10.37 | 18 | 584875 | 5107 | 63908732 |
Flatulence | 11.40 | 10.37 | 413 | 584480 | 35253 | 63878586 |
Lung diffusion test decreased | 11.37 | 10.37 | 30 | 584863 | 1166 | 63912673 |
Benign gastrointestinal neoplasm | 11.37 | 10.37 | 10 | 584883 | 139 | 63913700 |
Dysphonia | 11.35 | 10.37 | 522 | 584371 | 45860 | 63867979 |
Myasthenia gravis | 11.35 | 10.37 | 90 | 584803 | 5648 | 63908191 |
Neurosensory hypoacusis | 11.35 | 10.37 | 12 | 584881 | 212 | 63913627 |
Poor venous access | 11.35 | 10.37 | 66 | 584827 | 12351 | 63901488 |
Macroglossia | 11.34 | 10.37 | 28 | 584865 | 1044 | 63912795 |
Thromboangiitis obliterans | 11.34 | 10.37 | 6 | 584887 | 33 | 63913806 |
Tumour lysis syndrome | 11.33 | 10.37 | 117 | 584776 | 19323 | 63894516 |
Muscular weakness | 11.32 | 10.37 | 1320 | 583573 | 126018 | 63787821 |
Ureteric cancer | 11.31 | 10.37 | 13 | 584880 | 253 | 63913586 |
Ventricular drainage | 11.31 | 10.37 | 5 | 584888 | 17 | 63913822 |
Retinal ischaemia | 11.25 | 10.37 | 22 | 584871 | 698 | 63913141 |
Renal artery thrombosis | 11.25 | 10.37 | 17 | 584876 | 436 | 63913403 |
Peritoneal dialysis complication | 11.24 | 10.37 | 45 | 584848 | 2183 | 63911656 |
Gingival hypoplasia | 11.24 | 10.37 | 4 | 584889 | 6 | 63913833 |
Pleuroperitoneal communication | 11.24 | 10.37 | 4 | 584889 | 6 | 63913833 |
Hepatitis E | 11.22 | 10.37 | 4 | 584889 | 2427 | 63911412 |
Vaginal infection | 11.21 | 10.37 | 17 | 584876 | 4903 | 63908936 |
Giant cell arteritis | 11.21 | 10.37 | 46 | 584847 | 2257 | 63911582 |
Bone pain | 11.18 | 10.37 | 337 | 584556 | 47235 | 63866604 |
Product solubility abnormal | 11.18 | 10.37 | 24 | 584869 | 815 | 63913024 |
Metastases to central nervous system | 11.14 | 10.37 | 77 | 584816 | 13835 | 63900004 |
Glucose tolerance increased | 11.14 | 10.37 | 3 | 584890 | 0 | 63913839 |
Diabetic enteropathy | 11.14 | 10.37 | 3 | 584890 | 0 | 63913839 |
Craniectomy | 11.14 | 10.37 | 3 | 584890 | 0 | 63913839 |
Tear discolouration | 11.14 | 10.37 | 3 | 584890 | 0 | 63913839 |
Crush syndrome | 11.12 | 10.37 | 11 | 584882 | 179 | 63913660 |
Cogwheel rigidity | 11.10 | 10.37 | 6 | 584887 | 2847 | 63910992 |
Hydronephrosis | 11.10 | 10.37 | 185 | 584708 | 13940 | 63899899 |
Homicidal ideation | 11.09 | 10.37 | 8 | 584885 | 3249 | 63910590 |
Streptococcal infection | 11.05 | 10.37 | 33 | 584860 | 7446 | 63906393 |
Ventricular failure | 11.01 | 10.37 | 18 | 584875 | 495 | 63913344 |
Tenderness | 11.01 | 10.37 | 119 | 584774 | 19483 | 63894356 |
Brain abscess | 11 | 10.37 | 13 | 584880 | 4168 | 63909671 |
Cold sweat | 10.98 | 10.37 | 210 | 584683 | 16245 | 63897594 |
Electrocardiogram U wave present | 10.97 | 10.37 | 9 | 584884 | 113 | 63913726 |
Infected dermal cyst | 10.95 | 10.37 | 23 | 584870 | 769 | 63913070 |
Clostridium difficile infection | 10.93 | 10.37 | 247 | 584646 | 35916 | 63877923 |
Omphalitis | 10.92 | 10.37 | 6 | 584887 | 36 | 63913803 |
Appendicitis | 10.92 | 10.37 | 75 | 584818 | 13494 | 63900345 |
Respiratory arrest | 10.87 | 10.37 | 382 | 584511 | 52603 | 63861236 |
Inhibitory drug interaction | 10.84 | 10.37 | 63 | 584830 | 3564 | 63910275 |
Pneumothorax traumatic | 10.83 | 10.37 | 12 | 584881 | 224 | 63913615 |
Peripheral ischaemia | 10.83 | 10.37 | 120 | 584773 | 8258 | 63905581 |
Faeces hard | 10.82 | 10.37 | 43 | 584850 | 2079 | 63911760 |
Intestinal stenosis | 10.80 | 10.37 | 8 | 584885 | 3206 | 63910633 |
Osteoporotic fracture | 10.80 | 10.37 | 10 | 584883 | 3588 | 63910251 |
Skin candida | 10.77 | 10.37 | 37 | 584856 | 1666 | 63912173 |
Helicobacter gastritis | 10.75 | 10.37 | 44 | 584849 | 2156 | 63911683 |
IgA nephropathy | 10.74 | 10.37 | 33 | 584860 | 1401 | 63912438 |
Underdose | 10.74 | 10.37 | 167 | 584726 | 25662 | 63888177 |
Nystagmus | 10.72 | 10.37 | 44 | 584849 | 9024 | 63904815 |
Herbal interaction | 10.72 | 10.37 | 16 | 584877 | 406 | 63913433 |
Cardiac failure acute | 10.71 | 10.37 | 208 | 584685 | 16136 | 63897703 |
Brain contusion | 10.70 | 10.37 | 30 | 584863 | 1209 | 63912630 |
Kidney fibrosis | 10.70 | 10.37 | 56 | 584837 | 3045 | 63910794 |
Flour sensitivity | 10.69 | 10.37 | 5 | 584888 | 20 | 63913819 |
Retroperitoneal oedema | 10.69 | 10.37 | 5 | 584888 | 20 | 63913819 |
Malignant neoplasm of renal pelvis | 10.66 | 10.37 | 9 | 584884 | 118 | 63913721 |
Deformity | 10.65 | 10.37 | 26 | 584867 | 6271 | 63907568 |
Metabolic disorder | 10.64 | 10.37 | 35 | 584858 | 7662 | 63906177 |
Mycobacterium avium complex infection | 10.64 | 10.37 | 12 | 584881 | 3928 | 63909911 |
Rib deformity | 10.59 | 10.37 | 9 | 584884 | 119 | 63913720 |
Subarachnoid haemorrhage | 10.55 | 10.37 | 230 | 584663 | 18208 | 63895631 |
Splenic rupture | 10.55 | 10.37 | 44 | 584849 | 2175 | 63911664 |
Malignant hypertension | 10.54 | 10.37 | 33 | 584860 | 1415 | 63912424 |
Attention deficit hyperactivity disorder | 10.53 | 10.37 | 6 | 584887 | 2764 | 63911075 |
Generalised bullous fixed drug eruption | 10.53 | 10.37 | 4 | 584889 | 8 | 63913831 |
Splenomegaly | 10.51 | 10.37 | 108 | 584785 | 17853 | 63895986 |
Adrenal mass | 10.51 | 10.37 | 26 | 584867 | 971 | 63912868 |
Incorrect dose administered by device | 10.50 | 10.37 | 13 | 584880 | 4084 | 63909755 |
JC virus infection | 10.46 | 10.37 | 9 | 584884 | 3346 | 63910493 |
Stent malfunction | 10.44 | 10.37 | 7 | 584886 | 63 | 63913776 |
Menstruation irregular | 10.42 | 10.37 | 15 | 584878 | 4420 | 63909419 |
Heat illness | 10.42 | 10.37 | 15 | 584878 | 368 | 63913471 |
Basal ganglia stroke | 10.41 | 10.37 | 9 | 584884 | 122 | 63913717 |
Hypogammaglobulinaemia | 10.37 | 10.37 | 53 | 584840 | 10246 | 63903593 |
None
Source | Code | Description |
---|---|---|
ATC | C07FB07 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FB12 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FB13 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C08CA01 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
ATC | C08CA51 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
ATC | C08GA02 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS CALCIUM CHANNEL BLOCKERS AND DIURETICS Calcium channel blockers and diuretics |
ATC | C09BB03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09BB04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09BB07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09BX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09BX03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09BX04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09DB01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB02 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB05 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB09 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09XA53 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors |
ATC | C09XA54 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors |
ATC | C10BX03 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX09 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX11 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX14 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX18 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA CS | M0006414 | Dihydropyridines |
FDA MoA | N0000000069 | Calcium Channel Antagonists |
FDA EPC | N0000175421 | Dihydropyridine Calcium Channel Blocker |
FDA EPC | N0000175566 | Calcium Channel Blocker |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:38215 | calcium channel blockers |
FDA MoA | N0000190114 | Cytochrome P450 3A Inhibitors |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002121 | Calcium Channel Blockers |
MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D014665 | Vasodilator Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Prinzmetal angina | indication | 87343002 | |
Angina pectoris | indication | 194828000 | |
Cerebrovascular accident | indication | 230690007 | |
Primary Prevention of Coronary Heart Disease | indication | ||
Myocardial Infarction Prevention | indication | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Alcoholism | contraindication | 7200002 | |
Hyperkalemia | contraindication | 14140009 | |
Jaundice | contraindication | 18165001 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Obstruction of bile duct | contraindication | 30144000 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
Low blood pressure | contraindication | 45007003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Hemorrhagic cerebral infarction | contraindication | 230706003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Rhabdomyolysis | contraindication | 240131006 | |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Surgical procedure | contraindication | 387713003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Traumatic injury | contraindication | 417746004 | |
Azotemia | contraindication | 445009001 | |
Head and Neck Angioedema | contraindication | ||
Hemodialysis with High-Flux Membrane | contraindication | ||
Severe Aortic Valve Stenosis | contraindication | ||
Intestinal Angioedema | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.0 | Basic |
pKa2 | 1.55 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 10MG BASE;14MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 6696481 | April 15, 2023 | TREATMENT OF HYPERTENSION |
EQ 2.5MG BASE;3.5MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 6696481 | April 15, 2023 | TREATMENT OF HYPERTENSION |
EQ 5MG BASE;7MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 6696481 | April 15, 2023 | TREATMENT OF HYPERTENSION |
EQ 10MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9662315 | May 22, 2029 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 2.5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9662315 | May 22, 2029 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9662315 | May 22, 2029 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 10MG BASE;14MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 7846961 | Oct. 5, 2029 | TREATMENT OF HYPERTENSION |
EQ 2.5MG BASE;3.5MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 7846961 | Oct. 5, 2029 | TREATMENT OF HYPERTENSION |
EQ 5MG BASE;7MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 7846961 | Oct. 5, 2029 | TREATMENT OF HYPERTENSION |
EQ 10MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9408837 | Feb. 28, 2030 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 2.5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9408837 | Feb. 28, 2030 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9408837 | Feb. 28, 2030 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 10MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 10925835 | June 14, 2038 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 2.5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 10925835 | June 14, 2038 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 10925835 | June 14, 2038 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 1MG BASE/ML | NORLIQVA | CMP DEV LLC | N214439 | Feb. 24, 2022 | RX | SOLUTION | ORAL | 11253474 | Feb. 24, 2041 | NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA |
EQ 1MG BASE/ML | NORLIQVA | CMP DEV LLC | N214439 | Feb. 24, 2022 | RX | SOLUTION | ORAL | 11253474 | Feb. 24, 2041 | NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA |
EQ 1MG BASE/ML | NORLIQVA | CMP DEV LLC | N214439 | Feb. 24, 2022 | RX | SOLUTION | ORAL | 11253474 | Feb. 24, 2041 | NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | BLOCKER | WOMBAT-PK | CHEMBL | |||||
Voltage-dependent L-type calcium channel subunit alpha-1D | Ion channel | BLOCKER | Ki | 7 | WOMBAT-PK | CHEMBL | |||
Alpha-1A adrenergic receptor | GPCR | Ki | 5.63 | CHEMBL | |||||
Aldehyde oxidase | Enzyme | IC50 | 5.26 | WOMBAT-PK | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.58 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.36 | DRUG MATRIX | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 5.27 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 5.10 | CHEMBL | |||||
Voltage-dependent calcium channel gamma-1 subunit | Ion channel | Ki | 7.20 | WOMBAT-PK | |||||
Carbonic anhydrase 1 | Enzyme | WOMBAT-PK | |||||||
Voltage-dependent calcium channel subunit alpha-2/delta-1 | Ion channel | Ki | 7.20 | WOMBAT-PK | |||||
Voltage-dependent T-type calcium channel subunit alpha-1H | Ion channel | Ki | 4.51 | WOMBAT-PK | |||||
Potassium channel subfamily K member 2 | Ion channel | IC50 | 6.40 | CHEMBL | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.65 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.87 | DRUG MATRIX | |||||
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | Ki | 8.70 | CHEMBL | |||||
Potassium channel subfamily K member 2 | Ion channel | IC50 | 6.37 | CHEMBL |
ID | Source |
---|---|
4020813 | VUID |
N0000148333 | NUI |
D00615 | KEGG_DRUG |
111470-99-6 | SECONDARY_CAS_RN |
88150-47-4 | SECONDARY_CAS_RN |
104416 | RXNORM |
C0051696 | UMLSCUI |
CHEBI:2669 | CHEBI |
06X | PDB_CHEM_ID |
CHEMBL1491 | ChEMBL_ID |
CHEMBL1200402 | ChEMBL_ID |
D017311 | MESH_DESCRIPTOR_UI |
DB00381 | DRUGBANK_ID |
2162 | PUBCHEM_CID |
6981 | IUPHAR_LIGAND_ID |
5729 | INN_ID |
246852-12-0 | SECONDARY_CAS_RN |
1J444QC288 | UNII |
108736 | MMSL |
173594 | MMSL |
23944 | MMSL |
27341 | MMSL |
4180 | MMSL |
d00689 | MMSL |
003672 | NDDF |
003673 | NDDF |
008599 | NDDF |
015579 | NDDF |
4020586 | VANDF |
4020813 | VANDF |
CHEMBL1200984 | ChEMBL_ID |
108537001 | SNOMEDCT_US |
1193663008 | SNOMEDCT_US |
384976003 | SNOMEDCT_US |
386864001 | SNOMEDCT_US |
421048000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1520 | TABLET | 2.50 mg | ORAL | NDA | 26 sections |
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1520 | TABLET | 2.50 mg | ORAL | NDA | 26 sections |
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1530 | TABLET | 5 mg | ORAL | NDA | 26 sections |
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1530 | TABLET | 5 mg | ORAL | NDA | 26 sections |
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1540 | TABLET | 10 mg | ORAL | NDA | 26 sections |
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1540 | TABLET | 10 mg | ORAL | NDA | 26 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2150 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2150 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2160 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2160 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2170 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2170 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2180 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2180 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2190 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2190 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2250 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2250 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2260 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2260 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2270 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2270 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2960 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2970 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2980 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-6180 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-6323 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-6565 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-6747 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-7232 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |