amlodipine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 183 88150-42-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amlodipine
  • amlopres
  • racemic amlodipine
  • amlodipine besylate
  • amlodipine besilate
  • amlodipine maleate
  • amlodipine mesylate
  • amlodipine mesilate
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
  • Molecular weight: 408.88
  • Formula: C20H25ClN2O5
  • CLOGP: 3.43
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.88
  • ALOGS: -4.74
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.35 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 34 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 31, 1992 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5604.18 24.84 1546 11674 19488 2325377
Hypotension 3426.15 24.84 1176 12044 31260 2313605
Toxicity to various agents 3176.96 24.84 1115 12105 31639 2313226
Drug hypersensitivity 2219.66 24.84 948 12272 45695 2299170
Intentional overdose 1606.31 24.84 516 12704 10805 2334060
Overdose 1400.07 24.84 538 12682 19369 2325496
Oedema peripheral 1352.26 24.84 551 12669 23212 2321653
Dizziness 1269.24 24.84 697 12523 57968 2286897
Shock 1101.67 24.84 305 12915 3699 2341166
Fall 1062.14 24.84 576 12644 46523 2298342
Blood pressure increased 1006.20 24.84 406 12814 16580 2328285
Metabolic acidosis 946.35 24.84 297 12923 5701 2339164
Suicide attempt 914.72 24.84 339 12881 10943 2333922
Blood pressure inadequately controlled 894.83 24.84 193 13027 707 2344158
Acute kidney injury 860.49 24.84 423 12797 27699 2317166
Bradycardia 772.49 24.84 290 12930 9691 2335174
Drug interaction 761.03 24.84 394 12826 28769 2316096
Hypertension 708.92 24.84 368 12852 26993 2317872
Orthostatic hypotension 667.44 24.84 192 13028 2687 2342178
Headache 643.17 24.84 514 12706 79665 2265200
Gingival hypertrophy 605.21 24.84 120 13100 251 2344614
Malaise 585.94 24.84 420 12800 55165 2289700
Hyponatraemia 585.60 24.84 258 12962 13067 2331798
Joint swelling 564.53 24.84 270 12950 16549 2328316
Dyspnoea 545.63 24.84 464 12756 78269 2266596
Syncope 509.41 24.84 252 12968 16623 2328242
Angioedema 469.55 24.84 193 13027 8203 2336662
Vomiting 447.03 24.84 398 12822 71204 2273661
Cardiac arrest 444.66 24.84 221 12999 14709 2330156
Nausea 444.48 24.84 486 12734 111703 2233162
Peripheral swelling 424.45 24.84 226 12994 17371 2327494
Cough 396.34 24.84 271 12949 32846 2312019
Blood pressure decreased 393.06 24.84 175 13045 9061 2335804
Drug ineffective 386.02 24.84 431 12789 101193 2243672
Palpitations 378.99 24.84 205 13015 16251 2328614
Asthenia 374.87 24.84 301 12919 46625 2298240
Somnolence 373.88 24.84 230 12990 23255 2321610
Hyperkalaemia 365.54 24.84 146 13074 5747 2339118
Hypokalaemia 363.02 24.84 173 13047 10481 2334384
Depressed level of consciousness 358.92 24.84 155 13065 7449 2337416
Loss of consciousness 327.43 24.84 195 13025 18572 2326293
Pulmonary oedema 321.19 24.84 142 13078 7221 2337644
Renal impairment 313.95 24.84 154 13066 9938 2334927
Oedema 309.37 24.84 153 13067 10050 2334815
Cardiogenic shock 305.22 24.84 102 13118 2389 2342476
Circulatory collapse 301.50 24.84 112 13108 3608 2341257
Sinus bradycardia 301.00 24.84 97 13123 2019 2342846
Fatigue 297.93 24.84 346 12874 84527 2260338
Anuria 289.94 24.84 91 13129 1733 2343132
Toxic epidermal necrolysis 285.73 24.84 103 13117 3041 2341824
Cardiac failure 282.00 24.84 152 13068 11942 2332923
Confusional state 280.95 24.84 195 13025 24149 2320716
Tachycardia 274.47 24.84 166 13054 16243 2328622
Rash 273.62 24.84 280 12940 59278 2285587
Hypertensive crisis 269.04 24.84 93 13127 2420 2342445
Chest pain 264.47 24.84 199 13021 27938 2316927
Feeling abnormal 260.68 24.84 184 13036 23397 2321468
Swelling 254.53 24.84 158 13062 16192 2328673
Cardio-respiratory arrest 253.25 24.84 129 13091 9017 2335848
Swollen tongue 252.31 24.84 109 13111 5234 2339631
Pruritus 251.96 24.84 232 12988 43108 2301757
Cerebrovascular accident 245.35 24.84 167 13053 20019 2324846
Hypoglycaemia 236.90 24.84 120 13100 8287 2336578
Pain in extremity 228.54 24.84 218 13002 42322 2302543
Blood creatinine increased 227.82 24.84 126 13094 10407 2334458
Balance disorder 222.96 24.84 121 13099 9626 2335239
Atrioventricular block complete 222.44 24.84 70 13150 1344 2343521
Erythema 218.88 24.84 170 13050 24989 2319876
Swelling face 214.78 24.84 117 13103 9376 2335489
Coma 214.33 24.84 115 13105 8941 2335924
Condition aggravated 211.04 24.84 184 13036 31795 2313070
Heart rate increased 210.87 24.84 122 13098 10983 2333882
Lactic acidosis 210.69 24.84 96 13124 5234 2339631
Hyperglycaemia 205.84 24.84 92 13128 4793 2340072
Oliguria 200.31 24.84 64 13156 1293 2343572
Gait disturbance 197.50 24.84 153 13067 22392 2322473
Decreased appetite 194.15 24.84 168 13052 28723 2316142
Abdominal pain 191.83 24.84 180 13040 34194 2310671
Respiratory failure 191.12 24.84 123 13097 13405 2331460
Anxiety 189.80 24.84 167 13053 29192 2315673
Non-cardiogenic pulmonary oedema 185.16 24.84 38 13182 101 2344764
Death 184.71 24.84 268 12952 81200 2263665
Rhabdomyolysis 181.00 24.84 93 13127 6611 2338254
Diarrhoea 180.94 24.84 269 12951 83295 2261570
Muscular weakness 177.94 24.84 122 13098 14775 2330090
Atrial fibrillation 176.97 24.84 118 13102 13650 2331215
Respiratory arrest 176.38 24.84 89 13131 6089 2338776
Blood pressure systolic increased 173.39 24.84 66 13154 2273 2342592
Linear IgA disease 169.75 24.84 42 13178 312 2344553
Poisoning 168.28 24.84 68 13152 2752 2342113
Renal failure 167.92 24.84 125 13095 17224 2327641
Pain 167.82 24.84 222 12998 61635 2283230
Drug intolerance 167.76 24.84 114 13106 13603 2331262
Muscle spasms 162.48 24.84 134 13086 21432 2323433
Depression 162.05 24.84 150 13070 27982 2316883
Blood glucose increased 161.96 24.84 107 13113 12183 2332682
Abdominal pain upper 159.61 24.84 134 13086 21966 2322899
Myalgia 159.35 24.84 137 13083 23196 2321669
General physical health deterioration 157.62 24.84 111 13109 14028 2330837
Blister 157.41 24.84 85 13135 6686 2338179
Diabetes mellitus 154.74 24.84 87 13133 7408 2337457
Heart rate decreased 154.10 24.84 69 13151 3607 2341258
Left ventricular hypertrophy 153.86 24.84 45 13175 666 2344199
Asthma 152.72 24.84 100 13120 11214 2333651
Blood creatine phosphokinase increased 152.51 24.84 76 13144 5060 2339805
Dehydration 152.44 24.84 131 13089 22164 2322701
Sinus tachycardia 147.69 24.84 65 13155 3260 2341605
Generalised oedema 147.02 24.84 59 13161 2344 2342521
Urticaria 146.79 24.84 133 13087 24128 2320737
Tremor 146.55 24.84 124 13096 20537 2324328
Paraesthesia 145.38 24.84 127 13093 21961 2322904
Medication error 142.61 24.84 77 13143 6054 2338811
Disorientation 142.59 24.84 78 13142 6294 2338571
Urinary incontinence 141.75 24.84 68 13152 4165 2340700
Product substitution issue 141.69 24.84 72 13148 4997 2339868
Arthralgia 141.27 24.84 191 13029 54094 2290771
Insomnia 137.95 24.84 132 13088 25655 2319210
Arrhythmia 135.46 24.84 74 13146 5954 2338911
Visual impairment 134.99 24.84 94 13126 11661 2333204
Gingival bleeding 134.59 24.84 53 13167 2002 2342863
Vision blurred 133.72 24.84 102 13118 14566 2330299
Weight decreased 132.76 24.84 135 13085 28236 2316629
Stevens-Johnson syndrome 132.32 24.84 65 13155 4194 2340671
Vasoplegia syndrome 128.18 24.84 29 13191 138 2344727
Hypoxia 125.06 24.84 71 13149 6156 2338709
Exposure via ingestion 123.88 24.84 39 13181 749 2344116
Chest discomfort 123.26 24.84 97 13123 14498 2330367
Lethargy 122.30 24.84 79 13141 8651 2336214
Multiple organ dysfunction syndrome 121.70 24.84 75 13145 7566 2337299
Dysphagia 121.03 24.84 91 13129 12714 2332151
Blood lactic acid increased 120.93 24.84 39 13181 812 2344053
Personality disorder 119.20 24.84 32 13188 339 2344526
Dysarthria 118.93 24.84 69 13151 6233 2338632
Pollakiuria 118.70 24.84 58 13162 3698 2341167
Altered state of consciousness 117.20 24.84 58 13162 3802 2341063
Tachypnoea 116.85 24.84 49 13171 2180 2342685
Acute respiratory distress syndrome 116.68 24.84 55 13165 3237 2341628
Acute generalised exanthematous pustulosis 112.94 24.84 44 13176 1614 2343251
Hemiplegia 112.66 24.84 42 13178 1363 2343502
Tinnitus 112.51 24.84 62 13158 5073 2339792
Pemphigoid 111.51 24.84 38 13182 944 2343921
Gingival swelling 110.45 24.84 36 13184 776 2344089
Cardiotoxicity 110.05 24.84 40 13180 1207 2343658
Alanine aminotransferase increased 109.40 24.84 89 13131 13943 2330922
Pleural effusion 108.22 24.84 82 13138 11586 2333279
Aspartate aminotransferase increased 106.86 24.84 84 13136 12528 2332337
Constipation 106.79 24.84 106 13114 21523 2323342
Vertigo 105.29 24.84 74 13146 9310 2335555
Conjoined twins 103.06 24.84 18 13202 10 2344855
Dermatitis exfoliative 102.82 24.84 38 13182 1203 2343662
Electrocardiogram QT prolonged 102.82 24.84 68 13152 7746 2337119
Hypersensitivity 102.64 24.84 108 13112 23485 2321380
Blood cholesterol increased 100.52 24.84 58 13162 5183 2339682
Presyncope 100.42 24.84 52 13168 3751 2341114
Loose tooth 99.95 24.84 32 13188 650 2344215
Flushing 98.28 24.84 78 13142 11793 2333072
Myocardial depression 98.04 24.84 20 13200 51 2344814
Respiratory disorder 97.90 24.84 52 13168 3952 2340913
Blood pressure fluctuation 97.55 24.84 41 13179 1834 2343031
Blood urea increased 97.23 24.84 50 13170 3555 2341310
Weight increased 96.71 24.84 102 13118 22235 2322630
Renin increased 96.32 24.84 19 13201 38 2344827
Hyperlipidaemia 95.76 24.84 45 13175 2629 2342236
Respiratory depression 95.00 24.84 42 13178 2128 2342737
Suicidal ideation 94.26 24.84 74 13146 11013 2333852
Haemodynamic instability 93.64 24.84 35 13185 1144 2343721
Myocardial infarction 93.51 24.84 93 13127 18920 2325945
Vasodilatation 93.42 24.84 27 13193 382 2344483
Hepatitis 92.84 24.84 59 13161 6278 2338587
Intestinal ischaemia 92.57 24.84 34 13186 1057 2343808
Burning sensation 90.78 24.84 63 13157 7765 2337100
Dry mouth 90.08 24.84 64 13156 8189 2336676
Back pain 89.29 24.84 116 13104 31543 2313322
Parkinsonism 88.77 24.84 36 13184 1469 2343396
Urine output decreased 88.45 24.84 36 13184 1483 2343382
Blood pressure abnormal 87.76 24.84 37 13183 1668 2343197
Foetal exposure during pregnancy 87.32 24.84 53 13167 5199 2339666
Intentional product misuse 86.47 24.84 66 13154 9423 2335442
Seizure 85.70 24.84 100 13120 24366 2320499
Abdominal discomfort 85.13 24.84 85 13135 17371 2327494
Hypoperfusion 84.87 24.84 22 13198 201 2344664
Mental status changes 84.34 24.84 53 13167 5529 2339336
Lip swelling 83.63 24.84 50 13170 4771 2340094
Atrioventricular block 81.84 24.84 32 13188 1185 2343680
Atrioventricular block first degree 81.55 24.84 30 13190 937 2343928
Angina pectoris 81.49 24.84 46 13174 3941 2340924
Distributive shock 81.31 24.84 18 13202 76 2344789
Allergic reaction to excipient 81.06 24.84 17 13203 52 2344813
Unresponsive to stimuli 80.53 24.84 49 13171 4827 2340038
Gamma-glutamyltransferase increased 79.52 24.84 51 13169 5511 2339354
Aphasia 77.50 24.84 48 13172 4880 2339985
Hyperdynamic left ventricle 77.44 24.84 15 13205 26 2344839
Treatment noncompliance 77.29 24.84 50 13170 5484 2339381
Product prescribing error 76.79 24.84 40 13180 2920 2341945
Blood potassium decreased 76.73 24.84 49 13171 5256 2339609
Neurologic neglect syndrome 76.37 24.84 17 13203 74 2344791
Urachal abnormality 75.94 24.84 13 13207 5 2344860
Dyspepsia 75.78 24.84 62 13158 9782 2335083
Proteinuria 75.33 24.84 39 13181 2811 2342054
Therapy non-responder 75.23 24.84 57 13163 8047 2336818
Anaemia 74.95 24.84 112 13108 34680 2310185
Toxic skin eruption 74.71 24.84 36 13184 2224 2342641
Pneumonia 74.23 24.84 135 13085 49161 2295704
Face oedema 73.87 24.84 43 13177 3905 2340960
Disturbance in attention 73.63 24.84 49 13171 5636 2339229
Intestinal malrotation 73.59 24.84 15 13205 38 2344827
Product complaint 73.40 24.84 45 13175 4493 2340372
Pyrexia 73.29 24.84 141 13079 53567 2291298
Carotid artery thrombosis 73.01 24.84 17 13203 94 2344771
Liver disorder 72.91 24.84 51 13169 6363 2338502
Persistent cloaca 72.76 24.84 13 13207 10 2344855
Muscle spasticity 72.37 24.84 32 13188 1621 2343244
Chronic kidney disease 72.19 24.84 43 13177 4075 2340790
Poisoning deliberate 72.00 24.84 29 13191 1162 2343703
Electrocardiogram abnormal 71.88 24.84 30 13190 1318 2343547
Renal artery stenosis 71.62 24.84 20 13200 248 2344617
Subacute cutaneous lupus erythematosus 71.56 24.84 22 13198 389 2344476
Eating disorder 71.39 24.84 35 13185 2246 2342619
Glaucoma 71.16 24.84 34 13186 2061 2342804
Affect lability 71.06 24.84 34 13186 2068 2342797
Mitral valve incompetence 70.59 24.84 36 13184 2514 2342351
Nervousness 70.30 24.84 46 13174 5143 2339722
Congenital bladder anomaly 70.20 24.84 13 13207 15 2344850
Thrombocytopenia 70.01 24.84 80 13140 19051 2325814
Dysuria 68.69 24.84 41 13179 3900 2340965
Hepatic function abnormal 68.22 24.84 48 13172 6044 2338821
Acute motor-sensory axonal neuropathy 67.99 24.84 14 13206 38 2344827
Vasculitis 67.90 24.84 34 13186 2284 2342581
Sleep disorder 67.77 24.84 49 13171 6440 2338425
Gingivitis 67.06 24.84 29 13191 1392 2343473
Drug abuse 66.96 24.84 63 13157 11963 2332902
Memory impairment 66.84 24.84 65 13155 12858 2332007
Cellulitis 66.76 24.84 56 13164 9145 2335720
Eyelid oedema 66.73 24.84 35 13185 2591 2342274
Impaired work ability 66.47 24.84 31 13189 1779 2343086
Lichen nitidus 65.99 24.84 11 13209 2 2344863
Electrolyte imbalance 65.99 24.84 32 13188 2005 2342860
Irritable bowel syndrome 65.97 24.84 31 13189 1810 2343055
Hemiparesis 65.67 24.84 38 13182 3412 2341453
Cholelithiasis 65.63 24.84 46 13174 5757 2339108
Eczema 65.56 24.84 37 13183 3168 2341697
Blood alkaline phosphatase increased 65.13 24.84 48 13172 6497 2338368
Product dispensing error 64.95 24.84 34 13186 2507 2342358
Atrioventricular block second degree 64.55 24.84 23 13197 654 2344211
Adjustment disorder 64.20 24.84 17 13203 170 2344695
Photosensitivity reaction 63.53 24.84 33 13187 2394 2342471
Premature baby 62.88 24.84 36 13184 3168 2341697
Blood lactate dehydrogenase increased 62.69 24.84 37 13183 3447 2341418
Labile hypertension 62.16 24.84 14 13206 65 2344800
Urinary retention 60.93 24.84 37 13183 3630 2341235
Motor dysfunction 60.79 24.84 26 13194 1214 2343651
Hypoacusis 60.65 24.84 36 13184 3389 2341476
Purpura 60.34 24.84 29 13191 1781 2343084
Bladder irritation 60.10 24.84 13 13207 48 2344817
Low birth weight baby 60.01 24.84 23 13197 806 2344059
Pharyngeal oedema 59.99 24.84 36 13184 3457 2341408
Glycosylated haemoglobin increased 59.98 24.84 29 13191 1805 2343060
Ascites 59.97 24.84 43 13177 5577 2339288
Myocardial ischaemia 59.91 24.84 31 13189 2231 2342634
Wound 59.91 24.84 33 13187 2695 2342170
Haemoglobin decreased 59.91 24.84 72 13148 18079 2326786
Interstitial lung disease 59.70 24.84 49 13171 7763 2337102
Hypertensive emergency 59.52 24.84 17 13203 230 2344635
Cognitive disorder 59.33 24.84 42 13178 5339 2339526
Glomerular filtration rate decreased 59.30 24.84 27 13193 1466 2343399
Accidental overdose 58.21 24.84 37 13183 3935 2340930
Pallor 57.70 24.84 36 13184 3706 2341159
Hepatocellular injury 57.51 24.84 37 13183 4018 2340847
Lichen planus 57.12 24.84 19 13201 437 2344428
Coma scale abnormal 56.74 24.84 22 13198 796 2344069
Drug level increased 56.53 24.84 32 13188 2755 2342110
Bronchitis 56.44 24.84 61 13159 13653 2331212
Pulmonary hypoplasia 56.43 24.84 13 13207 68 2344797
Hyperthyroidism 56.29 24.84 29 13191 2068 2342797
Jaundice 56.17 24.84 41 13179 5467 2339398
Fryns syndrome 55.50 24.84 9 13211 0 2344865
Oesophageal atresia 55.44 24.84 14 13206 114 2344751
Visual acuity reduced 55.31 24.84 40 13180 5258 2339607
Hypoaesthesia 55.28 24.84 73 13147 20142 2324723
Dyspnoea exertional 54.78 24.84 41 13179 5679 2339186
Angiopathy 53.71 24.84 21 13199 777 2344088
Depressed mood 53.70 24.84 39 13181 5159 2339706
Product administration error 53.52 24.84 35 13185 3908 2340957
Cardiac disorder 53.39 24.84 46 13174 7787 2337078
Cardiac failure congestive 53.35 24.84 64 13156 16037 2328828
Chronic obstructive pulmonary disease 53.26 24.84 44 13176 7033 2337832
Rash erythematous 53.19 24.84 41 13179 5935 2338930
Bezoar 52.85 24.84 15 13205 198 2344667
Dermatitis 52.84 24.84 29 13191 2351 2342514
Body temperature decreased 52.78 24.84 24 13196 1299 2343566
Hypertensive angiopathy 52.19 24.84 9 13211 4 2344861
Cholecystitis 51.69 24.84 28 13192 2212 2342653
Exposure during pregnancy 51.18 24.84 79 13141 25140 2319725
Gravitational oedema 51.18 24.84 14 13206 160 2344705
Photophobia 51.12 24.84 28 13192 2261 2342604
Arteriosclerosis 50.08 24.84 24 13196 1464 2343401
Pulmonary fibrosis 50.03 24.84 29 13191 2611 2342254
Ventricular fibrillation 49.36 24.84 27 13193 2174 2342691
Fluid retention 49.29 24.84 42 13178 7004 2337861
Hyperhidrosis 48.97 24.84 60 13160 15362 2329503
Pseudolymphoma 48.82 24.84 13 13207 133 2344732
Incorrect dose administered 48.70 24.84 48 13172 9647 2335218
Wrong product administered 48.68 24.84 23 13197 1359 2343506
Sedation 48.48 24.84 31 13189 3331 2341534
Productive cough 48.43 24.84 37 13183 5284 2339581
Blood sodium decreased 48.24 24.84 30 13190 3070 2341795
Mental disorder 48.21 24.84 33 13187 3974 2340891
Nodal rhythm 48.18 24.84 16 13204 366 2344499
Nocturia 48.10 24.84 20 13200 870 2343995
Cholestasis 48.00 24.84 32 13188 3689 2341176
Abdominal distension 47.63 24.84 49 13171 10362 2334503
Drug reaction with eosinophilia and systemic symptoms 47.24 24.84 37 13183 5481 2339384
Discomfort 47.24 24.84 36 13184 5123 2339742
Renal disorder 47.11 24.84 34 13186 4454 2340411
Tracheo-oesophageal fistula 46.96 24.84 12 13208 103 2344762
Therapeutic response unexpected 46.94 24.84 32 13188 3827 2341038
Purpura senile 46.31 24.84 9 13211 16 2344849
Coordination abnormal 46.29 24.84 25 13195 1963 2342902
Bundle branch block left 46.16 24.84 20 13200 964 2343901
Alopecia 46.16 24.84 70 13150 21931 2322934
Congenital diaphragmatic hernia 45.80 24.84 10 13210 39 2344826
Asphyxia 45.77 24.84 20 13200 984 2343881
Extrasystoles 45.49 24.84 20 13200 999 2343866
Cerebral infarction 45.18 24.84 33 13187 4404 2340461
Head discomfort 44.80 24.84 23 13197 1628 2343237
Rash macular 44.67 24.84 30 13190 3501 2341364
Platelet count decreased 44.61 24.84 58 13162 15755 2329110
Nasopharyngitis 44.61 24.84 69 13151 21987 2322878
Brain natriuretic peptide increased 44.54 24.84 17 13203 589 2344276
Muscle tightness 44.48 24.84 24 13196 1881 2342984
Haemangioma congenital 44.30 24.84 11 13209 83 2344782
Heart rate irregular 44.25 24.84 26 13194 2401 2342464
Blood potassium increased 43.96 24.84 25 13195 2171 2342694
Hypertonic bladder 43.77 24.84 15 13205 379 2344486
Labelled drug-drug interaction medication error 43.73 24.84 21 13199 1287 2343578
Agitation 43.46 24.84 48 13172 11003 2333862
Rales 43.46 24.84 20 13200 1113 2343752
Congenital nail disorder 43.29 24.84 9 13211 26 2344839
Sensory loss 43.27 24.84 20 13200 1124 2343741
Skin ulcer 43.17 24.84 31 13189 4028 2340837
Lacrimation increased 43.06 24.84 27 13193 2803 2342062
Respiratory distress 43.06 24.84 34 13186 5095 2339770
Epistaxis 42.89 24.84 45 13175 9734 2335131
Microtia 42.84 24.84 10 13210 56 2344809
Coronary artery disease 42.77 24.84 36 13184 5903 2338962
Dysgeusia 42.70 24.84 42 13178 8417 2336448
Maternal exposure during pregnancy 42.69 24.84 55 13165 14808 2330057
Transient ischaemic attack 42.56 24.84 36 13184 5942 2338923
Bundle branch block right 42.26 24.84 18 13202 832 2344033
Arthritis 42.17 24.84 45 13175 9923 2334942
Speech disorder 42.12 24.84 37 13183 6427 2338438
Sleep apnoea syndrome 42.01 24.84 24 13196 2102 2342763
Sinoatrial block 41.96 24.84 12 13208 163 2344702
Diabetes mellitus inadequate control 41.91 24.84 23 13197 1864 2343001
Feeling hot 41.86 24.84 38 13182 6890 2337975
Phlebitis 41.79 24.84 19 13201 1028 2343837
Left atrial dilatation 41.12 24.84 13 13207 253 2344612
Musculoskeletal stiffness 41.08 24.84 49 13171 12198 2332667
Urine albumin/creatinine ratio increased 41.04 24.84 9 13211 36 2344829
Ventricular extrasystoles 41.03 24.84 23 13197 1943 2342922
Laryngeal oedema 41.01 24.84 20 13200 1268 2343597
Hyperuricaemia 40.97 24.84 16 13204 590 2344275
Oligohydramnios 40.15 24.84 18 13202 942 2343923
Ileus paralytic 40.05 24.84 17 13203 779 2344086
Aortic stenosis 40.03 24.84 16 13204 628 2344237
Restlessness 39.93 24.84 31 13189 4532 2340333
Petechiae 39.90 24.84 23 13197 2049 2342816
Transaminases increased 39.79 24.84 31 13189 4556 2340309
Retching 39.47 24.84 23 13197 2091 2342774
Blindness 39.33 24.84 28 13192 3590 2341275
Rash pruritic 39.13 24.84 38 13182 7497 2337368
Oxygen saturation decreased 38.92 24.84 38 13182 7548 2337317
Cataract 38.86 24.84 34 13186 5874 2338991
Urinary tract infection 38.81 24.84 77 13143 29865 2315000
Bradypnoea 38.58 24.84 14 13206 420 2344445
Pneumonia aspiration 38.48 24.84 28 13192 3714 2341151
Pulse abnormal 38.29 24.84 13 13207 319 2344546
Movement disorder 38.13 24.84 25 13195 2803 2342062
Cardiac failure acute 37.98 24.84 18 13202 1071 2343794
Aplastic anaemia 37.97 24.84 17 13203 887 2343978
Electrocardiogram QRS complex prolonged 37.78 24.84 18 13202 1084 2343781
Scleral discolouration 37.67 24.84 10 13210 101 2344764
Overweight 37.64 24.84 14 13206 451 2344414
Eye disorder 37.52 24.84 26 13194 3193 2341672
Leukocytosis 37.32 24.84 27 13193 3549 2341316
Eosinophilia 37.01 24.84 25 13195 2945 2341920
Reaction to excipient 36.98 24.84 13 13207 355 2344510
CD30 expression 36.96 24.84 7 13213 10 2344855
Blood pH decreased 36.90 24.84 14 13206 477 2344388
Hot flush 36.81 24.84 36 13184 7163 2337702
Carotid artery stenosis 36.68 24.84 16 13204 784 2344081
Head injury 36.60 24.84 28 13192 4006 2340859
Limb malformation 36.42 24.84 10 13210 116 2344749
Contusion 36.15 24.84 47 13173 12763 2332102
Peripheral coldness 36.03 24.84 20 13200 1657 2343208
Tarsal tunnel syndrome 35.90 24.84 8 13212 35 2344830
Optic nerve injury 35.88 24.84 10 13210 123 2344742
Fluid overload 35.88 24.84 24 13196 2782 2342083
Flatulence 35.86 24.84 29 13191 4496 2340369
Tongue oedema 35.75 24.84 16 13204 834 2344031
Agranulocytosis 35.68 24.84 26 13194 3456 2341409
Inflammation 35.44 24.84 33 13187 6180 2338685
Cyanosis 35.43 24.84 25 13195 3160 2341705
Hypocalcaemia 35.33 24.84 27 13193 3856 2341009
Throat irritation 35.21 24.84 30 13190 5000 2339865
Hypokinesia 35.20 24.84 20 13200 1734 2343131
Sprue-like enteropathy 35.14 24.84 9 13211 78 2344787
Lip disorder 34.99 24.84 11 13209 210 2344655
Drug eruption 34.91 24.84 25 13195 3234 2341631
Blood pressure diastolic decreased 34.86 24.84 17 13203 1078 2343787
Myopathy 34.80 24.84 19 13201 1524 2343341
Haemodialysis 34.69 24.84 21 13199 2048 2342817
Spinal pain 34.38 24.84 18 13202 1327 2343538
Melaena 34.00 24.84 27 13193 4079 2340786
Ischaemia 33.60 24.84 15 13205 777 2344088
Diplopia 33.54 24.84 25 13195 3440 2341425
C-reactive protein increased 33.34 24.84 32 13188 6223 2338642
Glucose urine present 33.23 24.84 10 13210 164 2344701
Hallucination 33.09 24.84 36 13184 8112 2336753
Crepitations 32.76 24.84 14 13206 652 2344213
Pulmonary hypertension 32.75 24.84 29 13191 5089 2339776
Bowel movement irregularity 32.50 24.84 13 13207 511 2344354
Chronic pigmented purpura 32.33 24.84 7 13213 26 2344839
Respiratory rate increased 32.31 24.84 18 13202 1502 2343363
Listless 32.25 24.84 12 13208 387 2344478
Ocular hyperaemia 32.16 24.84 26 13194 4030 2340835
Hyperaldosteronism 32.14 24.84 8 13212 61 2344804
Disseminated intravascular coagulation 32.04 24.84 24 13196 3326 2341539
Cardiomegaly 31.86 24.84 21 13199 2375 2342490
Bifascicular block 31.72 24.84 7 13213 29 2344836
Food interaction 31.56 24.84 10 13210 196 2344669
Renal tubular necrosis 31.55 24.84 18 13202 1572 2343293
Tubulointerstitial nephritis 31.53 24.84 21 13199 2417 2342448
Peroneal nerve palsy 31.38 24.84 14 13206 724 2344141
Sinus arrest 31.37 24.84 11 13209 298 2344567
Optic atrophy 31.30 24.84 11 13209 300 2344565
Foetal growth restriction 31.27 24.84 16 13204 1124 2343741
Deep vein thrombosis 31.25 24.84 44 13176 12888 2331977
Neck pain 31.24 24.84 34 13186 7663 2337202
Electrocardiogram ST segment depression 31.18 24.84 13 13207 569 2344296
Cytotoxic oedema 31.17 24.84 7 13213 32 2344833
Psychomotor retardation 31.16 24.84 13 13207 570 2344295
Feeling cold 31.10 24.84 23 13197 3127 2341738
Gastrointestinal haemorrhage 31.08 24.84 43 13177 12392 2332473
Blood urine present 31.01 24.84 19 13201 1893 2342972
Concomitant disease progression 30.97 24.84 12 13208 433 2344432
Bromhidrosis 30.83 24.84 5 13215 0 2344865
Diabetic nephropathy 30.83 24.84 10 13210 212 2344653
Self-medication 30.82 24.84 13 13207 586 2344279
Mixed liver injury 30.73 24.84 11 13209 317 2344548
Organ failure 30.72 24.84 12 13208 443 2344422
Panic attack 30.60 24.84 25 13195 3931 2340934
Craniofacial deformity 30.42 24.84 6 13214 12 2344853
Liver function test abnormal 30.25 24.84 33 13187 7457 2337408
Ageusia 30.24 24.84 19 13201 1979 2342886
Cleft palate 30.14 24.84 10 13210 228 2344637
Hypotonia 30.14 24.84 18 13202 1712 2343153
Gastrooesophageal reflux disease 29.86 24.84 36 13184 9059 2335806
Lung disorder 29.79 24.84 30 13190 6182 2338683
Lymphocyte stimulation test positive 29.78 24.84 10 13210 237 2344628
Blood bilirubin increased 29.73 24.84 28 13192 5317 2339548
Multiple fractures 29.70 24.84 13 13207 642 2344223
Anaphylactic reaction 29.58 24.84 37 13183 9668 2335197
Eye oedema 29.41 24.84 11 13209 360 2344505
Lower respiratory tract infection 29.38 24.84 28 13192 5396 2339469
Troponin increased 29.25 24.84 15 13205 1059 2343806
Orthostatic intolerance 29.17 24.84 9 13211 161 2344704
Acute myocardial infarction 29.12 24.84 27 13193 5028 2339837
Wheezing 29.11 24.84 30 13190 6354 2338511
Rash maculo-papular 29.03 24.84 25 13195 4227 2340638
Acute coronary syndrome 29.03 24.84 17 13203 1560 2343305
Gait inability 29.00 24.84 29 13191 5926 2338939
Blood calcium decreased 28.90 24.84 19 13201 2139 2342726
Blood aldosterone increased 28.69 24.84 6 13214 18 2344847
Angina unstable 28.56 24.84 16 13204 1350 2343515
Creatinine renal clearance decreased 28.49 24.84 14 13206 902 2343963
Hepatic steatosis 28.49 24.84 22 13198 3191 2341674
Dysmorphism 28.36 24.84 11 13209 398 2344467
Antipsychotic drug level above therapeutic 28.33 24.84 9 13211 178 2344687
Retinal ischaemia 28.30 24.84 8 13212 104 2344761
Blood glucose decreased 28.25 24.84 22 13198 3230 2341635
Gingival atrophy 28.21 24.84 6 13214 20 2344845
Pancreatitis 28.21 24.84 33 13187 8046 2336819
Dermatosis 28.09 24.84 8 13212 107 2344758
Blood pressure systolic decreased 27.93 24.84 13 13207 742 2344123
Eye pain 27.93 24.84 26 13194 4865 2340000
Polyuria 27.90 24.84 15 13205 1167 2343698
Conduction disorder 27.81 24.84 10 13210 292 2344573
Chills 27.79 24.84 46 13174 15506 2329359
Amnesia 27.64 24.84 31 13189 7222 2337643
Gout 27.61 24.84 16 13204 1439 2343426
Macular degeneration 27.42 24.84 15 13205 1208 2343657
Left ventricular dysfunction 27.22 24.84 15 13205 1225 2343640
Ventricular hypokinesia 27.09 24.84 12 13208 610 2344255
Continuous haemodiafiltration 27.06 24.84 10 13210 316 2344549
Micturition urgency 27.04 24.84 15 13205 1241 2343624
Chromaturia 26.95 24.84 20 13200 2733 2342132
Muscle twitching 26.87 24.84 20 13200 2745 2342120
Mouth ulceration 26.70 24.84 23 13197 3889 2340976
Ejection fraction decreased 26.64 24.84 20 13200 2781 2342084
Hypothermia 26.57 24.84 18 13202 2130 2342735
Hypersensitivity vasculitis 26.54 24.84 15 13205 1287 2343578
Neuralgia 26.51 24.84 20 13200 2802 2342063
Vestibular disorder 26.50 24.84 9 13211 221 2344644
Dry eye 26.48 24.84 23 13197 3933 2340932
Trigeminal neuralgia 26.46 24.84 12 13208 645 2344220
Hepatic failure 26.42 24.84 27 13193 5662 2339203
Musculoskeletal pain 26.39 24.84 37 13183 10793 2334072
Muscle atrophy 26.32 24.84 14 13206 1066 2343799
Hypercreatininaemia 26.25 24.84 7 13213 72 2344793
Periodontitis 26.17 24.84 12 13208 662 2344203
Patent ductus arteriosus 26.17 24.84 12 13208 662 2344203
Hepatic enzyme increased 26.16 24.84 35 13185 9767 2335098
Increased upper airway secretion 26.15 24.84 12 13208 663 2344202
Hypothyroidism 26.05 24.84 24 13196 4433 2340432
Caesarean section 25.86 24.84 23 13197 4058 2340807
Wrong technique in product usage process 25.83 24.84 51 13169 19697 2325168
Gingival pain 25.80 24.84 14 13206 1109 2343756
Drug level above therapeutic 25.79 24.84 11 13209 510 2344355
Pelvic fracture 25.78 24.84 15 13205 1360 2343505
Rhinitis 25.73 24.84 14 13206 1115 2343750
Vertigo positional 25.65 24.84 10 13210 367 2344498
Blood chloride decreased 25.64 24.84 12 13208 694 2344171
Hypoalbuminaemia 25.59 24.84 15 13205 1379 2343486
Coarctation of the aorta 25.58 24.84 8 13212 150 2344715
Hepatitis cholestatic 25.41 24.84 14 13206 1143 2343722
Inhibitory drug interaction 25.35 24.84 9 13211 253 2344612
Withdrawal hypertension 25.35 24.84 6 13214 36 2344829
Forced expiratory volume decreased 25.31 24.84 11 13209 534 2344331
Osteoarthritis 25.30 24.84 29 13191 6917 2337948
Gastroenteritis 25.07 24.84 20 13200 3040 2341825
Pancreatitis acute 24.98 24.84 22 13198 3831 2341034
Neuropathy peripheral 24.85 24.84 37 13183 11395 2333470

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5067.72 26.24 1463 10078 14849 1720391
Hypotension 2752.33 26.24 1076 10465 28578 1706662
Toxicity to various agents 2479.38 26.24 994 10547 28147 1707093
Intentional overdose 1459.06 26.24 477 11064 7193 1728047
Overdose 1237.32 26.24 519 11022 16182 1719058
Shock 1069.18 26.24 326 11215 3835 1731405
Acute kidney injury 945.41 26.24 546 10995 34398 1700842
Bradycardia 906.27 26.24 365 11176 10169 1725071
Drug hypersensitivity 866.97 26.24 393 11148 14742 1720498
Suicide attempt 815.99 26.24 307 11234 7074 1728166
Oedema peripheral 788.06 26.24 371 11170 15179 1720061
Drug interaction 699.32 26.24 416 11125 27542 1707698
Gingival hypertrophy 688.09 26.24 143 11398 244 1734996
Dizziness 674.23 26.24 438 11103 33923 1701317
Hypertension 672.22 26.24 358 11183 19090 1716150
Syncope 656.27 26.24 318 11223 13851 1721389
Blood pressure increased 633.07 26.24 285 11256 10468 1724772
Metabolic acidosis 532.83 26.24 207 11334 5195 1730045
Blood pressure inadequately controlled 527.38 26.24 125 11416 488 1734752
Fall 498.87 26.24 333 11208 26881 1708359
Pulmonary oedema 496.46 26.24 208 11333 6378 1728862
Dyspnoea 405.94 26.24 385 11156 51674 1683566
Lactic acidosis 403.24 26.24 167 11374 4962 1730278
Loss of consciousness 382.67 26.24 226 11315 14649 1720591
Cardiogenic shock 375.28 26.24 130 11411 2324 1732916
Renal failure 359.08 26.24 242 11299 19775 1715465
Cardiac arrest 358.13 26.24 222 11319 15708 1719532
Hyperkalaemia 350.78 26.24 177 11364 8370 1726870
Hypertensive crisis 350.65 26.24 110 11431 1417 1733823
Headache 348.06 26.24 295 11246 34081 1701159
Angioedema 347.25 26.24 183 11358 9481 1725759
Orthostatic hypotension 322.22 26.24 127 11414 3304 1731936
Blood pressure decreased 283.69 26.24 148 11393 7498 1727742
Hypokalaemia 267.25 26.24 134 11407 6240 1729000
Blood creatinine increased 255.49 26.24 171 11370 13775 1721465
Malaise 249.37 26.24 229 11312 29336 1705904
Cardiac failure 241.63 26.24 159 11382 12443 1722797
Drug ineffective 233.35 26.24 319 11222 63482 1671758
Oedema 214.30 26.24 119 11422 6829 1728411
Rhabdomyolysis 207.87 26.24 138 11403 10952 1724288
Myalgia 201.64 26.24 155 11386 15503 1719737
Hyperglycaemia 197.27 26.24 102 11439 5063 1730177
Chest pain 197.05 26.24 169 11372 19745 1715495
Joint swelling 196.42 26.24 109 11432 6244 1728996
Nausea 189.89 26.24 258 11283 50938 1684302
Palpitations 189.30 26.24 109 11432 6705 1728535
Heart rate decreased 189.08 26.24 82 11459 2727 1732513
Vomiting 184.54 26.24 220 11321 38095 1697145
Pruritus 178.51 26.24 171 11370 23051 1712189
Hyponatraemia 173.47 26.24 114 11427 8886 1726354
Haemodynamic instability 170.74 26.24 62 11479 1275 1733965
Acidosis 167.53 26.24 63 11478 1434 1733806
Electrocardiogram QRS complex prolonged 166.11 26.24 53 11488 722 1734518
Cough 166.05 26.24 151 11390 19046 1716194
Asthenia 165.10 26.24 198 11343 34472 1700768
Swollen tongue 163.34 26.24 74 11467 2734 1732506
Renal impairment 158.67 26.24 122 11419 12192 1723048
Depressed level of consciousness 158.32 26.24 96 11445 6496 1728744
Agranulocytosis 158.12 26.24 78 11463 3498 1731742
Blood creatine phosphokinase increased 155.80 26.24 106 11435 8750 1726490
Diabetes mellitus 154.17 26.24 96 11445 6812 1728428
Condition aggravated 153.58 26.24 151 11390 20999 1714241
Cardio-respiratory arrest 153.52 26.24 107 11434 9186 1726054
Erectile dysfunction 152.36 26.24 82 11459 4415 1730825
Fatigue 150.21 26.24 230 11311 50551 1684689
Circulatory collapse 148.47 26.24 74 11467 3393 1731847
Poisoning 148.14 26.24 67 11474 2465 1732775
Hypoxia 143.59 26.24 87 11454 5876 1729364
Anaemia 139.75 26.24 168 11373 29289 1705951
Peripheral swelling 139.23 26.24 95 11446 7876 1727364
Respiratory failure 139.08 26.24 121 11420 14384 1720856
Blood pressure systolic increased 135.44 26.24 56 11485 1649 1733591
Somnolence 133.71 26.24 126 11415 16613 1718627
Weight increased 132.20 26.24 106 11435 11251 1723989
Angina pectoris 130.66 26.24 77 11464 4941 1730299
Swelling 128.43 26.24 86 11455 6910 1728330
Paraesthesia 126.89 26.24 100 11441 10351 1724889
Medication error 126.70 26.24 74 11467 4669 1730571
Electrocardiogram QT prolonged 126.08 26.24 78 11463 5467 1729773
Hypoglycaemia 125.14 26.24 91 11450 8347 1726893
Eczema 124.97 26.24 58 11483 2266 1732974
Left ventricular hypertrophy 121.94 26.24 43 11498 809 1734431
Blood lactic acid increased 119.68 26.24 43 11498 856 1734384
Exposure via ingestion 119.43 26.24 40 11501 640 1734600
Weight decreased 118.18 26.24 136 11405 22617 1712623
Atrial fibrillation 117.33 26.24 112 11429 14999 1720241
Cardiomegaly 115.48 26.24 55 11486 2279 1732961
Rash 115.27 26.24 176 11365 38517 1696723
Blood glucose increased 115.18 26.24 95 11446 10489 1724751
Intentional product misuse 115.16 26.24 82 11459 7276 1727964
Gingival bleeding 114.68 26.24 46 11495 1250 1733990
Presyncope 113.77 26.24 57 11484 2641 1732599
Anuria 113.74 26.24 51 11490 1837 1733403
Confusional state 113.57 26.24 129 11412 21149 1714091
Vertigo 113.00 26.24 67 11474 4346 1730894
Arrhythmia 112.93 26.24 75 11466 5941 1729299
Leukocytosis 110.17 26.24 61 11480 3472 1731768
Lethargy 109.99 26.24 79 11462 7105 1728135
Muscular weakness 109.46 26.24 91 11450 10158 1725082
Chronic kidney disease 109.12 26.24 65 11476 4252 1730988
Nocturia 108.97 26.24 43 11498 1118 1734122
Tachycardia 108.42 26.24 99 11442 12529 1722711
Cholestasis 108.08 26.24 61 11480 3604 1731636
Vasoplegia syndrome 107.28 26.24 28 11513 174 1735066
Pain in extremity 105.43 26.24 116 11425 18356 1716884
Respiratory arrest 105.28 26.24 71 11470 5768 1729472
Gait disturbance 104.25 26.24 97 11444 12573 1722667
Dyspnoea exertional 103.48 26.24 62 11479 4099 1731141
Gingival swelling 103.33 26.24 31 11510 339 1734901
Drug eruption 100.89 26.24 54 11487 2872 1732368
Chest discomfort 97.35 26.24 74 11467 7257 1727983
Arthralgia 97.10 26.24 125 11416 23319 1711921
Death 96.57 26.24 263 11278 87180 1648060
Non-cardiogenic pulmonary oedema 95.90 26.24 23 11518 95 1735145
Pneumonia 93.64 26.24 177 11364 46005 1689235
Diabetes mellitus inadequate control 92.94 26.24 44 11497 1798 1733442
Anxiety 92.93 26.24 100 11441 15427 1719813
Poisoning deliberate 92.61 26.24 35 11506 807 1734433
Haemoglobin decreased 91.68 26.24 104 11437 17010 1718230
Tricuspid valve incompetence 89.16 26.24 38 11503 1208 1734032
Atrioventricular block 88.89 26.24 39 11502 1332 1733908
Drug reaction with eosinophilia and systemic symptoms 87.47 26.24 60 11481 5010 1730230
Oliguria 87.26 26.24 37 11504 1161 1734079
Drug intolerance 86.73 26.24 64 11477 5998 1729242
Lip swelling 86.43 26.24 48 11493 2747 1732493
Muscle spasms 86.14 26.24 84 11457 11537 1723703
Generalised oedema 85.64 26.24 41 11500 1718 1733522
Hyperhidrosis 84.68 26.24 86 11455 12402 1722838
Dysarthria 83.17 26.24 59 11482 5200 1730040
Atrioventricular block complete 83.10 26.24 38 11503 1433 1733807
Therapy non-responder 82.63 26.24 63 11478 6203 1729037
Distributive shock 82.55 26.24 21 11520 116 1735124
Atrioventricular block first degree 82.04 26.24 33 11508 903 1734337
Pain 81.73 26.24 123 11418 26534 1708706
Acute respiratory distress syndrome 80.82 26.24 50 11491 3501 1731739
Pyrexia 79.76 26.24 166 11375 46234 1689006
Sinus tachycardia 79.71 26.24 44 11497 2488 1732752
Hypovolaemic shock 79.54 26.24 32 11509 876 1734364
Cardiotoxicity 78.87 26.24 31 11510 797 1734443
Eosinophilia 78.59 26.24 49 11492 3478 1731762
Tachypnoea 77.05 26.24 42 11499 2316 1732924
Glycosylated haemoglobin increased 76.93 26.24 39 11502 1852 1733388
Cerebral infarction 76.79 26.24 56 11485 5153 1730087
Heart rate increased 76.20 26.24 61 11480 6449 1728791
Guillain-Barre syndrome 75.94 26.24 31 11510 882 1734358
Gamma-glutamyltransferase increased 75.59 26.24 55 11486 5043 1730197
Pemphigoid 75.57 26.24 33 11508 1114 1734126
Mental status changes 75.56 26.24 59 11482 6016 1729224
Cerebrovascular accident 75.09 26.24 96 11445 17770 1717470
Blood urea increased 74.83 26.24 53 11488 4658 1730582
Decreased appetite 74.38 26.24 111 11430 23760 1711480
Abdominal pain 74.33 26.24 105 11436 21385 1713855
Body temperature decreased 74.21 26.24 32 11509 1047 1734193
Toxic skin eruption 74.17 26.24 38 11503 1845 1733395
Left ventricular enlargement 73.98 26.24 16 11525 36 1735204
Stress 72.61 26.24 42 11499 2599 1732641
General physical health deterioration 72.41 26.24 81 11460 13037 1722203
Pleural effusion 70.78 26.24 74 11467 11036 1724204
Pancreatitis acute 69.63 26.24 48 11493 4039 1731201
Unresponsive to stimuli 68.76 26.24 50 11491 4579 1730661
Visual impairment 67.99 26.24 56 11485 6162 1729078
Hyperleukocytosis 67.74 26.24 18 11523 121 1735119
Dry mouth 66.76 26.24 46 11495 3867 1731373
Alanine aminotransferase increased 66.37 26.24 75 11466 12203 1723037
Arteriosclerosis 66.24 26.24 35 11506 1812 1733428
Pericardial effusion 65.37 26.24 43 11498 3347 1731893
Dehydration 65.11 26.24 89 11452 17569 1717671
Drug-induced liver injury 64.72 26.24 42 11499 3195 1732045
Dermatomyositis 64.38 26.24 20 11521 248 1734992
C-reactive protein increased 64.34 26.24 53 11488 5832 1729408
Cerebral haemorrhage 63.40 26.24 54 11487 6223 1729017
Diastolic dysfunction 62.37 26.24 23 11518 494 1734746
Abdominal distension 62.17 26.24 54 11487 6390 1728850
Urine output decreased 61.99 26.24 31 11510 1429 1733811
Aortic stenosis 61.98 26.24 24 11517 592 1734648
Continuous haemodiafiltration 61.83 26.24 20 11521 285 1734955
Feeling abnormal 61.70 26.24 69 11472 11097 1724143
Depression 61.43 26.24 84 11457 16585 1718655
Gingivitis 61.35 26.24 24 11517 609 1734631
Swelling face 61.14 26.24 46 11495 4437 1730803
Wrong patient received product 61.00 26.24 18 11523 185 1735055
Coma 60.46 26.24 56 11485 7206 1728034
Hyperlipidaemia 60.08 26.24 35 11506 2194 1733046
Fluid overload 60.02 26.24 34 11507 2021 1733219
Gout 59.94 26.24 37 11504 2579 1732661
Drug abuse 59.78 26.24 75 11466 13614 1721626
Hepatic function abnormal 59.76 26.24 55 11486 7019 1728221
Differentiation syndrome 59.63 26.24 17 11524 153 1735087
Asthma 59.62 26.24 47 11494 4857 1730383
Nodal rhythm 59.58 26.24 20 11521 322 1734918
Myocardial depression 59.45 26.24 12 11529 16 1735224
Vitamin D deficiency 59.33 26.24 22 11519 480 1734760
Blood sodium decreased 59.01 26.24 35 11506 2269 1732971
Peripheral coldness 58.99 26.24 28 11513 1150 1734090
Chronic pigmented purpura 58.46 26.24 13 11528 35 1735205
Macrophages increased 58.39 26.24 11 11530 7 1735233
Cardiac failure congestive 57.86 26.24 78 11463 15192 1720048
Blood pressure diastolic decreased 57.41 26.24 24 11517 726 1734514
Back pain 57.16 26.24 81 11460 16532 1718708
Discomfort 57.16 26.24 36 11505 2600 1732640
Proteinuria 57.10 26.24 37 11504 2807 1732433
Insomnia 56.95 26.24 80 11461 16196 1719044
Oropharyngeal pain 56.06 26.24 45 11496 4773 1730467
Liver disorder 55.92 26.24 48 11493 5588 1729652
Pharyngeal oedema 55.55 26.24 30 11511 1623 1733617
Left ventricular dysfunction 55.24 26.24 27 11514 1184 1734056
Diabetic neuropathy 55.08 26.24 21 11520 496 1734744
Product prescribing error 55.00 26.24 34 11507 2376 1732864
Blood pressure abnormal 54.96 26.24 26 11515 1060 1734180
Haemodialysis 54.91 26.24 35 11506 2581 1732659
Red blood cell sedimentation rate increased 54.80 26.24 26 11515 1067 1734173
Hepatotoxicity 54.37 26.24 37 11504 3047 1732193
Aspartate aminotransferase increased 53.58 26.24 63 11478 10693 1724547
Vision blurred 53.44 26.24 56 11485 8367 1726873
Constipation 52.88 26.24 74 11467 14926 1720314
Hepatic steatosis 52.82 26.24 34 11507 2550 1732690
Coma scale abnormal 52.08 26.24 21 11520 578 1734662
Interstitial lung disease 52 26.24 59 11482 9637 1725603
Type 2 diabetes mellitus 51.97 26.24 30 11511 1848 1733392
Speech disorder 51.90 26.24 42 11499 4506 1730734
Intentional self-injury 51.77 26.24 34 11507 2639 1732601
Fluid retention 51.75 26.24 39 11502 3770 1731470
Steatorrhoea 51.71 26.24 14 11527 102 1735138
Dermatitis exfoliative 51.54 26.24 28 11513 1533 1733707
Lower respiratory tract infection 51.37 26.24 39 11502 3812 1731428
Crystalluria 51.22 26.24 13 11528 71 1735169
Alveolitis 51.16 26.24 18 11523 336 1734904
Hepatitis 50.79 26.24 43 11498 4912 1730328
Diarrhoea 50.47 26.24 153 11388 53699 1681541
Blood pressure fluctuation 50.29 26.24 26 11515 1286 1733954
Pseudolymphoma 49.81 26.24 14 11527 119 1735121
Acute pulmonary oedema 49.21 26.24 25 11516 1192 1734048
Multiple organ dysfunction syndrome 49.16 26.24 56 11485 9186 1726054
Sinus bradycardia 48.55 26.24 29 11512 1904 1733336
Mitral valve incompetence 48.43 26.24 29 11512 1913 1733327
Septic shock 48.06 26.24 52 11489 8057 1727183
Peripheral ischaemia 47.70 26.24 22 11519 846 1734394
Flushing 47.64 26.24 46 11495 6233 1729007
Thrombocytopenia 47.40 26.24 85 11456 21164 1714076
Wheezing 46.64 26.24 38 11503 4115 1731125
C-reactive protein decreased 46.47 26.24 12 11529 71 1735169
Chronic obstructive pulmonary disease 45.90 26.24 44 11497 5909 1729331
Vasculitis 45.83 26.24 26 11515 1549 1733691
Depressed mood 45.74 26.24 33 11508 2983 1732257
Petechiae 45.68 26.24 26 11515 1559 1733681
Blood chloride increased 45.31 26.24 16 11525 302 1734938
Jaundice 45.22 26.24 44 11497 6018 1729222
Haematochezia 44.90 26.24 40 11501 4892 1730348
Coronary artery disease 44.66 26.24 55 11486 9791 1725449
Platelet count decreased 44.65 26.24 72 11469 16451 1718789
Ejection fraction decreased 44.56 26.24 29 11512 2216 1733024
Abdominal pain upper 44.43 26.24 58 11483 10943 1724297
Arterial stenosis 44.32 26.24 14 11527 184 1735056
Blood potassium decreased 43.97 26.24 29 11512 2266 1732974
Hypomagnesaemia 43.86 26.24 28 11513 2070 1733170
Epistaxis 43.61 26.24 50 11491 8256 1726984
Product substitution issue 43.21 26.24 33 11508 3253 1731987
Hypoaesthesia 43.10 26.24 54 11487 9781 1725459
Hypovolaemia 43.05 26.24 23 11518 1217 1734023
Hypertensive heart disease 42.89 26.24 17 11524 447 1734793
Erythema 42.74 26.24 65 11476 14123 1721117
Bundle branch block right 42.62 26.24 23 11518 1242 1733998
Hypoperfusion 42.19 26.24 14 11527 217 1735023
Hyperkaliuria 41.93 26.24 8 11533 6 1735234
Troponin I increased 41.39 26.24 15 11526 306 1734934
Primary hyperaldosteronism 41.39 26.24 9 11532 21 1735219
Cutaneous lupus erythematosus 41.28 26.24 13 11528 169 1735071
Brain injury 41.16 26.24 21 11520 1010 1734230
Treatment noncompliance 41.15 26.24 39 11502 5162 1730078
Gynaecomastia 40.99 26.24 27 11514 2105 1733135
Respiratory alkalosis 40.84 26.24 14 11527 241 1734999
Toxic epidermal necrolysis 40.74 26.24 28 11513 2343 1732897
Accidental overdose 40.36 26.24 35 11506 4129 1731111
Pulmonary congestion 40.01 26.24 25 11516 1780 1733460
Lacrimal disorder 40.00 26.24 9 11532 26 1735214
Transient ischaemic attack 39.97 26.24 37 11504 4754 1730486
Urinary retention 39.94 26.24 39 11502 5356 1729884
Foetal exposure during pregnancy 39.83 26.24 42 11499 6317 1728923
Urticaria 39.62 26.24 58 11483 12183 1723057
Tubulointerstitial nephritis 39.55 26.24 30 11511 2928 1732312
Respiratory distress 39.53 26.24 38 11503 5119 1730121
Hepatocellular injury 39.34 26.24 31 11510 3200 1732040
Carotid sinus syndrome 39.08 26.24 8 11533 12 1735228
Drug level increased 38.98 26.24 29 11512 2748 1732492
Hepatitis cholestatic 38.96 26.24 22 11519 1299 1733941
Heart rate irregular 38.93 26.24 24 11517 1668 1733572
Face oedema 38.75 26.24 27 11514 2309 1732931
Aortic aneurysm 38.61 26.24 20 11521 993 1734247
Paralysis 38.48 26.24 22 11519 1330 1733910
Pulseless electrical activity 38.48 26.24 20 11521 1000 1734240
Myocardial infarction 38.40 26.24 90 11451 27084 1708156
Albumin urine present 38.33 26.24 10 11531 62 1735178
Necrotising oesophagitis 38.05 26.24 10 11531 64 1735176
Acute biphenotypic leukaemia 37.97 26.24 8 11533 15 1735225
Rash maculo-papular 37.67 26.24 32 11509 3671 1731569
Myopathy 37.41 26.24 24 11517 1789 1733451
Blood bicarbonate decreased 37.33 26.24 15 11526 409 1734831
Ventricular hyperkinesia 37.30 26.24 8 11533 17 1735223
Product complaint 37.20 26.24 27 11514 2463 1732777
Nephropathy 36.99 26.24 19 11522 927 1734313
Blood potassium increased 36.82 26.24 27 11514 2503 1732737
Base excess decreased 36.81 26.24 9 11532 41 1735199
Supraventricular tachycardia 36.77 26.24 23 11518 1640 1733600
Productive cough 36.46 26.24 31 11510 3560 1731680
Blood pressure systolic decreased 36.30 26.24 17 11524 677 1734563
Colitis 36.27 26.24 33 11508 4147 1731093
Libido decreased 36.22 26.24 21 11520 1304 1733936
Stevens-Johnson syndrome 36.19 26.24 30 11511 3327 1731913
Splenic rupture 36.05 26.24 14 11527 348 1734892
Extrapyramidal disorder 36.03 26.24 26 11515 2351 1732889
Cardiorenal syndrome 35.90 26.24 10 11531 82 1735158
Pallor 35.78 26.24 30 11511 3381 1731859
Haemoptysis 35.63 26.24 35 11506 4841 1730399
Drug dispensed to wrong patient 35.59 26.24 8 11533 23 1735217
Parkinsonism 35.58 26.24 21 11520 1348 1733892
Left atrial enlargement 35.48 26.24 9 11532 49 1735191
Muscle necrosis 35.47 26.24 12 11529 198 1735042
Tinnitus 35.38 26.24 29 11512 3166 1732074
Osmolar gap abnormal 35.27 26.24 7 11534 8 1735232
Hypervolaemia 35.21 26.24 11 11530 139 1735101
Ischaemic stroke 35.17 26.24 29 11512 3193 1732047
Cardiac murmur 35.09 26.24 20 11521 1202 1734038
Nephrotic syndrome 34.93 26.24 21 11520 1395 1733845
Thrombocytosis 34.64 26.24 16 11525 617 1734623
Feeling cold 34.14 26.24 22 11519 1652 1733588
Implant site infection 34.10 26.24 13 11528 307 1734933
Dysphagia 34.10 26.24 49 11492 10119 1725121
Respiratory rate increased 34.03 26.24 20 11521 1274 1733966
Disturbance in attention 33.97 26.24 32 11509 4202 1731038
Plasmapheresis 33.93 26.24 9 11532 60 1735180
Kinematic imbalances due to suboccipital strain 33.87 26.24 6 11535 1 1735239
Polyuria 33.80 26.24 20 11521 1290 1733950
Blood ethanol increased 33.68 26.24 9 11532 62 1735178
Ventricular hypertrophy 33.49 26.24 17 11524 809 1734431
Inflammation 33.44 26.24 29 11512 3421 1731819
Implant site extravasation 33.30 26.24 11 11530 168 1735072
Mitral valve thickening 33.26 26.24 7 11534 13 1735227
Sudden death 33.22 26.24 27 11514 2913 1732327
Product administration error 33.11 26.24 27 11514 2926 1732314
Conjunctival hyperaemia 33.10 26.24 15 11526 553 1734687
Renal artery stenosis 33.10 26.24 12 11529 245 1734995
Altered state of consciousness 33.10 26.24 29 11512 3468 1731772
Cold sweat 33.07 26.24 22 11519 1744 1733496
Brain natriuretic peptide increased 33.03 26.24 15 11526 556 1734684
Hypersensitivity vasculitis 32.99 26.24 19 11522 1165 1734075
Coronary artery stenosis 32.78 26.24 21 11520 1561 1733679
Hypercholesterolaemia 32.58 26.24 19 11522 1193 1734047
Seizure 32.54 26.24 71 11470 20370 1714870
Scar 32.51 26.24 17 11524 861 1734379
Foot deformity 32.49 26.24 14 11527 457 1734783
Oxygen consumption decreased 32.45 26.24 8 11533 38 1735202
Breath sounds abnormal 32.20 26.24 15 11526 590 1734650
Immune thrombocytopenic purpura 32.19 26.24 20 11521 1409 1733831
Hypertrophy 32.07 26.24 9 11532 76 1735164
Orthostatic intolerance 31.97 26.24 10 11531 127 1735113
Electrocardiogram ST segment elevation 31.48 26.24 17 11524 919 1734321
Alcohol poisoning 31.36 26.24 14 11527 498 1734742
Dialysis 31.30 26.24 24 11517 2380 1732860
Periodontitis 31.18 26.24 12 11529 291 1734949
Renal ischaemia 30.99 26.24 9 11532 87 1735153
Product monitoring error 30.99 26.24 9 11532 87 1735153
Skin lesion 30.88 26.24 26 11515 2946 1732294
Concomitant disease progression 30.85 26.24 14 11527 518 1734722
Right atrial enlargement 30.67 26.24 7 11534 22 1735218
Purpura 30.59 26.24 21 11520 1753 1733487
Foetal growth restriction 30.45 26.24 15 11526 669 1734571
Blood uric acid increased 30.29 26.24 17 11524 992 1734248
Skin exfoliation 30.28 26.24 31 11510 4504 1730736
Nightmare 30.24 26.24 25 11516 2762 1732478
Skin ulcer 30.23 26.24 25 11516 2763 1732477
Gait inability 30.06 26.24 27 11514 3336 1731904
Eosinophil count increased 30.03 26.24 19 11522 1382 1733858
Haematocrit decreased 29.98 26.24 30 11511 4243 1730997
Ascites 29.95 26.24 34 11507 5552 1729688
Urinary tract infection 29.84 26.24 46 11495 10107 1725133
Contusion 29.64 26.24 33 11508 5276 1729964
Delirium 29.59 26.24 36 11505 6326 1728914
Low birth weight baby 29.53 26.24 16 11525 871 1734369
Renal tubular necrosis 29.45 26.24 22 11519 2097 1733143
Electrocardiogram T wave inversion 29.35 26.24 13 11528 454 1734786
Cranial sutures widening 29.31 26.24 6 11535 9 1735231
Stenosis 29.23 26.24 9 11532 108 1735132
Gastrointestinal disorder 29.09 26.24 31 11510 4717 1730523
Coordination abnormal 28.88 26.24 19 11522 1478 1733762
Hypersensitivity 28.87 26.24 46 11495 10398 1724842
Renal artery thrombosis 28.67 26.24 8 11533 66 1735174
Scratch 28.67 26.24 13 11528 480 1734760
White blood cell count increased 28.66 26.24 38 11503 7274 1727966
Oedema mouth 28.64 26.24 12 11529 365 1734875
Hypothermia 28.52 26.24 20 11521 1728 1733512
Respiratory tract haemorrhage 28.51 26.24 9 11532 118 1735122
Head injury 28.46 26.24 25 11516 2999 1732241
Throat irritation 28.46 26.24 20 11521 1734 1733506
Respiratory tract infection 28.39 26.24 23 11518 2470 1732770
Mouth swelling 28.30 26.24 11 11530 274 1734966
Bladder catheterisation 28.30 26.24 9 11532 121 1735119
Extrasystoles 28.21 26.24 15 11526 786 1734454
Rash erythematous 28.11 26.24 28 11513 3937 1731303
High density lipoprotein decreased 28.01 26.24 14 11527 644 1734596
Conjunctival haemorrhage 28.01 26.24 13 11528 507 1734733
Hypochromasia 27.93 26.24 7 11534 36 1735204
International normalised ratio increased 27.83 26.24 40 11501 8259 1726981
Mobility decreased 27.79 26.24 28 11513 3992 1731248
Cardiac tamponade 27.75 26.24 16 11525 983 1734257
Respiratory disorder 27.59 26.24 25 11516 3124 1732116
Lymphomatoid papulosis 27.58 26.24 8 11533 77 1735163
Cholelithiasis 27.48 26.24 25 11516 3140 1732100
Paraplegia 27.47 26.24 13 11528 530 1734710
Blister 27.37 26.24 28 11513 4064 1731176
Accidental exposure to product 27.32 26.24 28 11513 4073 1731167
Myocardial ischaemia 27.29 26.24 25 11516 3168 1732072
Left ventricular failure 27.20 26.24 14 11527 686 1734554
Herbal interaction 27.17 26.24 7 11534 41 1735199
Onychomycosis 27.07 26.24 11 11530 309 1734931
Acute respiratory failure 27.06 26.24 24 11517 2916 1732324
Hyperplasia 27.03 26.24 9 11532 141 1735099
Injury 26.92 26.24 24 11517 2936 1732304
Haemorrhagic stroke 26.78 26.24 17 11524 1244 1733996
Neutrophilia 26.72 26.24 13 11528 564 1734676
Memory impairment 26.69 26.24 35 11506 6628 1728612
Therapeutic product effect decreased 26.67 26.24 34 11507 6263 1728977
Pulmonary hypertension 26.47 26.24 23 11518 2719 1732521
Chills 26.35 26.24 47 11494 11640 1723600
Rash pruritic 26.31 26.24 28 11513 4254 1730986

Pharmacologic Action:

SourceCodeDescription
ATC C08CA01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C07FB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB12 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C08CA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08GA02 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
CALCIUM CHANNEL BLOCKERS AND DIURETICS
Calcium channel blockers and diuretics
ATC C09BB03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09DB01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB09 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09XA53 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C09XA54 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX09 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX14 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175421 Dihydropyridine Calcium Channel Blocker
FDA CS M0006414 Dihydropyridines
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35620 vasodilator agent
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Anuria contraindication 2472002 DOID:2983
Alcoholism contraindication 7200002
Hyperkalemia contraindication 14140009
Jaundice contraindication 18165001
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Obstruction of bile duct contraindication 30144000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypothyroidism contraindication 40930008 DOID:1459
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Azotemia contraindication 445009001
Head and Neck Angioedema contraindication
Hemodialysis with High-Flux Membrane contraindication
Severe Aortic Valve Stenosis contraindication
Intestinal Angioedema contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.0 Basic
pKa2 1.55 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 10MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 6696481 April 15, 2023 TREATMENT OF HYPERTENSION
EQ 2.5MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 6696481 April 15, 2023 TREATMENT OF HYPERTENSION
EQ 5MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 6696481 April 15, 2023 TREATMENT OF HYPERTENSION
EQ 10MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 10MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 2.5MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 5MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 10MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINATION
EQ 2.5MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINATION
EQ 5MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel BLOCKER Ki 7 WOMBAT-PK CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER WOMBAT-PK CHEMBL
Voltage-dependent calcium channel gamma-1 subunit Ion channel Ki 7.20 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.65 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.87 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.58 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.36 DRUG MATRIX
Carbonic anhydrase 1 Enzyme WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.26 WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 4.51 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 5.27 CHEMBL
Potassium channel subfamily K member 2 Ion channel IC50 6.40 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 5.63 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.10 CHEMBL
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel Ki 7.20 WOMBAT-PK
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 8.70 CHEMBL

External reference:

IDSource
4020813 VUID
N0000148333 NUI
C0051696 UMLSCUI
D00615 KEGG_DRUG
1J444QC288 UNII
5729 INN_ID
246852-12-0 SECONDARY_CAS_RN
108537001 SNOMEDCT_US
4020813 VANDF
27341 MMSL
003672 NDDF
17767 RXNORM
d00689 MMSL
386864001 SNOMEDCT_US
173594 MMSL
CHEMBL1491 ChEMBL_ID
DB00381 DRUGBANK_ID
CHEMBL1200402 ChEMBL_ID
06X PDB_CHEM_ID
6UB PDB_CHEM_ID
CHEBI:2668 CHEBI
6981 IUPHAR_LIGAND_ID
CHEMBL1200984 ChEMBL_ID
D017311 MESH_DESCRIPTOR_UI
2162 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Amlodipine Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0100 TABLET 2.50 mg ORAL ANDA 16 sections
Amlodipine Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0101 TABLET 5 mg ORAL ANDA 16 sections
Amlodipine Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0102 TABLET 10 mg ORAL ANDA 16 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1520 TABLET 2.50 mg ORAL NDA 17 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1530 TABLET 5 mg ORAL NDA 17 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1540 TABLET 10 mg ORAL NDA 17 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 5 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 5 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 5 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 5 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2960 TABLET, FILM COATED 2.50 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2970 TABLET, FILM COATED 2.50 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2980 TABLET, FILM COATED 2.50 mg ORAL NDA 19 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0364 CAPSULE 10 mg ORAL NDA 18 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0379 CAPSULE 10 mg ORAL NDA 18 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0405 CAPSULE 5 mg ORAL NDA 18 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0406 CAPSULE 5 mg ORAL NDA 18 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0488 TABLET, FILM COATED 5 mg ORAL NDA 18 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0489 TABLET, FILM COATED 10 mg ORAL NDA 18 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0490 TABLET, FILM COATED 5 mg ORAL NDA 18 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0491 TABLET, FILM COATED 10 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0559 TABLET, FILM COATED 5 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0560 TABLET, FILM COATED 5 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0561 TABLET, FILM COATED 10 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0562 TABLET, FILM COATED 10 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0563 TABLET, FILM COATED 10 mg ORAL NDA 18 sections