Stem definition | Drug id | CAS RN |
---|---|---|
calcium channel blockers, nifedipine derivatives | 183 | 88150-42-9 |
Dose | Unit | Route |
---|---|---|
5 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.35 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 74 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 17 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 7 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 34 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 31, 1992 | FDA | PFIZER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 644.44 | 9.89 | 2921 | 361792 | 674917 | 45646432 |
Rheumatoid arthritis | 587.82 | 9.89 | 606 | 364107 | 239609 | 46081740 |
Completed suicide | 399.25 | 9.89 | 2217 | 362496 | 143703 | 46177646 |
Maternal exposure during pregnancy | 379.14 | 9.89 | 163 | 364550 | 102386 | 46218963 |
Blood pressure inadequately controlled | 377.58 | 9.89 | 297 | 364416 | 4109 | 46317240 |
Treatment failure | 363.67 | 9.89 | 136 | 364577 | 92951 | 46228398 |
Hyponatraemia | 351.54 | 9.89 | 1646 | 363067 | 99686 | 46221663 |
Hypotension | 348.34 | 9.89 | 3049 | 361664 | 229540 | 46091809 |
Hypertension | 342.76 | 9.89 | 2665 | 362048 | 193691 | 46127658 |
Gingival hypertrophy | 328.88 | 9.89 | 179 | 364534 | 1250 | 46320099 |
Acute kidney injury | 327.71 | 9.89 | 3042 | 361671 | 232813 | 46088536 |
Blood pressure increased | 320.44 | 9.89 | 1885 | 362828 | 124781 | 46196568 |
Off label use | 315.35 | 9.89 | 1713 | 363000 | 378128 | 45943221 |
Shock | 288.29 | 9.89 | 570 | 364143 | 21275 | 46300074 |
Non-cardiogenic pulmonary oedema | 277.67 | 9.89 | 119 | 364594 | 445 | 46320904 |
Exposure during pregnancy | 267.65 | 9.89 | 270 | 364443 | 107942 | 46213407 |
Contraindicated product administered | 266.66 | 9.89 | 146 | 364567 | 79801 | 46241548 |
Pemphigus | 247.36 | 9.89 | 31 | 364682 | 45243 | 46276106 |
Oedema peripheral | 244.18 | 9.89 | 2104 | 362609 | 157602 | 46163747 |
Bradycardia | 225.45 | 9.89 | 1071 | 363642 | 65227 | 46256122 |
Drug intolerance | 222.75 | 9.89 | 513 | 364200 | 146536 | 46174813 |
Systemic lupus erythematosus | 213.08 | 9.89 | 122 | 364591 | 65058 | 46256291 |
Cerebrovascular accident | 212.66 | 9.89 | 1435 | 363278 | 99604 | 46221745 |
Infusion related reaction | 211.13 | 9.89 | 289 | 364424 | 100919 | 46220430 |
Synovitis | 210.35 | 9.89 | 107 | 364606 | 60968 | 46260381 |
Therapeutic product effect decreased | 197.56 | 9.89 | 212 | 364501 | 82389 | 46238960 |
Hyperkalaemia | 178.84 | 9.89 | 828 | 363885 | 49881 | 46271468 |
Fall | 178.67 | 9.89 | 3583 | 361130 | 325514 | 45995835 |
Abortion spontaneous | 178.57 | 9.89 | 59 | 364654 | 43587 | 46277762 |
Pain | 174.87 | 9.89 | 2649 | 362064 | 474299 | 45847050 |
Angioedema | 170.74 | 9.89 | 684 | 364029 | 38658 | 46282691 |
Therapeutic product effect incomplete | 157.17 | 9.89 | 229 | 364484 | 77924 | 46243425 |
Lactic acidosis | 153.16 | 9.89 | 597 | 364116 | 33312 | 46288037 |
Dizziness | 152.07 | 9.89 | 3604 | 361109 | 336810 | 45984539 |
C-reactive protein abnormal | 147.29 | 9.89 | 4 | 364709 | 21266 | 46300083 |
Hand deformity | 144.52 | 9.89 | 45 | 364668 | 34529 | 46286820 |
Device expulsion | 143.04 | 9.89 | 22 | 364691 | 27520 | 46293829 |
Pregnancy | 140.20 | 9.89 | 22 | 364691 | 27115 | 46294234 |
Glossodynia | 138.09 | 9.89 | 88 | 364625 | 44285 | 46277064 |
Drug abuse | 137.37 | 9.89 | 176 | 364537 | 63232 | 46258117 |
Anti-cyclic citrullinated peptide antibody positive | 134.86 | 9.89 | 3 | 364710 | 19142 | 46302207 |
Injection site reaction | 133.05 | 9.89 | 107 | 364606 | 47742 | 46273607 |
Cardiac failure congestive | 129.86 | 9.89 | 1189 | 363524 | 90561 | 46230788 |
Metabolic acidosis | 128.54 | 9.89 | 622 | 364091 | 38158 | 46283191 |
Injection site erythema | 128.34 | 9.89 | 241 | 364472 | 74186 | 46247163 |
Vasoplegia syndrome | 128.24 | 9.89 | 89 | 364624 | 1003 | 46320346 |
Renal impairment | 127.53 | 9.89 | 1006 | 363707 | 73366 | 46247983 |
Alopecia | 123.80 | 9.89 | 752 | 363961 | 161662 | 46159687 |
Orthostatic hypotension | 123.69 | 9.89 | 449 | 364264 | 24209 | 46297140 |
Rheumatoid factor positive | 122.16 | 9.89 | 10 | 364703 | 20451 | 46300898 |
Arthropathy | 120.64 | 9.89 | 305 | 364408 | 84395 | 46236954 |
Injection site pain | 118.22 | 9.89 | 434 | 364279 | 106718 | 46214631 |
Hypertensive crisis | 117.50 | 9.89 | 300 | 364413 | 13315 | 46308034 |
Hypokalaemia | 111.33 | 9.89 | 1114 | 363599 | 86910 | 46234439 |
Hypoglycaemia | 107.81 | 9.89 | 761 | 363952 | 53588 | 46267761 |
Arthralgia | 100.32 | 9.89 | 2129 | 362584 | 362474 | 45958875 |
Pericarditis | 98.47 | 9.89 | 32 | 364681 | 23895 | 46297454 |
Product use issue | 96.27 | 9.89 | 396 | 364317 | 94248 | 46227101 |
Intentional overdose | 96.15 | 9.89 | 850 | 363863 | 64094 | 46257255 |
Sinusitis | 95.15 | 9.89 | 608 | 364105 | 129160 | 46192189 |
Atrial fibrillation | 94.45 | 9.89 | 1230 | 363483 | 102360 | 46218989 |
Atrioventricular block complete | 91.11 | 9.89 | 191 | 364522 | 7436 | 46313913 |
Blood creatinine increased | 89.04 | 9.89 | 951 | 363762 | 75452 | 46245897 |
Migraine | 88.64 | 9.89 | 267 | 364446 | 69759 | 46251590 |
Febrile neutropenia | 87.70 | 9.89 | 410 | 364303 | 94217 | 46227132 |
Hepatic enzyme increased | 85.19 | 9.89 | 339 | 364374 | 81448 | 46239901 |
Cerebral infarction | 84.92 | 9.89 | 385 | 364328 | 22981 | 46298368 |
Hypersensitivity | 82.12 | 9.89 | 764 | 363949 | 149557 | 46171792 |
Decreased appetite | 81.42 | 9.89 | 2036 | 362677 | 191800 | 46129549 |
Myocardial infarction | 81.08 | 9.89 | 1139 | 363574 | 96389 | 46224960 |
Injection site swelling | 79.27 | 9.89 | 120 | 364593 | 40207 | 46281142 |
Syncope | 76.95 | 9.89 | 1198 | 363515 | 103605 | 46217744 |
Intentional self-injury | 75.08 | 9.89 | 48 | 364665 | 24118 | 46297231 |
Condition aggravated | 74.77 | 9.89 | 1406 | 363307 | 243646 | 46077703 |
Foetal exposure during pregnancy | 74.50 | 9.89 | 78 | 364635 | 30669 | 46290680 |
Rhabdomyolysis | 73.52 | 9.89 | 570 | 364143 | 41339 | 46280010 |
Swollen tongue | 73.10 | 9.89 | 434 | 364279 | 28798 | 46292551 |
Hypertensive emergency | 72.98 | 9.89 | 76 | 364637 | 1542 | 46319807 |
Product prescribing error | 71.87 | 9.89 | 329 | 364384 | 19718 | 46301631 |
Infection | 71.66 | 9.89 | 682 | 364031 | 132910 | 46188439 |
Neutropenia | 70.62 | 9.89 | 746 | 363967 | 142458 | 46178891 |
Neurologic neglect syndrome | 69.27 | 9.89 | 51 | 364662 | 635 | 46320714 |
Drug resistance | 68.41 | 9.89 | 25 | 364688 | 17343 | 46304006 |
Pyrexia | 68.28 | 9.89 | 2140 | 362573 | 346662 | 45974687 |
Infective pulmonary exacerbation of cystic fibrosis | 68.24 | 9.89 | 4 | 364709 | 10803 | 46310546 |
Musculoskeletal stiffness | 67.84 | 9.89 | 467 | 364246 | 97526 | 46223823 |
Sinus bradycardia | 66.62 | 9.89 | 248 | 364465 | 13534 | 46307815 |
Sprue-like enteropathy | 66.30 | 9.89 | 42 | 364671 | 401 | 46320948 |
Product use in unapproved indication | 64.59 | 9.89 | 426 | 364287 | 89847 | 46231502 |
Blood pressure decreased | 63.59 | 9.89 | 705 | 364008 | 56454 | 46264895 |
Injection site pruritus | 62.26 | 9.89 | 136 | 364577 | 39607 | 46281742 |
Renal failure | 62.10 | 9.89 | 1239 | 363474 | 112355 | 46208994 |
Live birth | 61.80 | 9.89 | 5 | 364708 | 10325 | 46311024 |
Atrioventricular block first degree | 58.32 | 9.89 | 141 | 364572 | 6045 | 46315304 |
Toxicity to various agents | 58.21 | 9.89 | 2111 | 362602 | 209655 | 46111694 |
Linear IgA disease | 57.96 | 9.89 | 62 | 364651 | 1299 | 46320050 |
Coronary artery disease | 57.51 | 9.89 | 456 | 364257 | 33296 | 46288053 |
Depressed level of consciousness | 55.82 | 9.89 | 593 | 364120 | 46976 | 46274373 |
Carotid artery thrombosis | 55.74 | 9.89 | 46 | 364667 | 684 | 46320665 |
Cardiac failure | 55.70 | 9.89 | 906 | 363807 | 79042 | 46242307 |
Fibromyalgia | 55.30 | 9.89 | 127 | 364586 | 36336 | 46285013 |
Blood urea increased | 54.42 | 9.89 | 362 | 364351 | 24990 | 46296359 |
Angina pectoris | 53.71 | 9.89 | 376 | 364337 | 26399 | 46294950 |
Loss of personal independence in daily activities | 53.41 | 9.89 | 247 | 364466 | 56936 | 46264413 |
Circulatory collapse | 52.75 | 9.89 | 319 | 364394 | 21305 | 46300044 |
Anuria | 52.20 | 9.89 | 202 | 364511 | 11229 | 46310120 |
Left ventricular hypertrophy | 52.12 | 9.89 | 118 | 364595 | 4845 | 46316504 |
Acute myocardial infarction | 52.06 | 9.89 | 427 | 364286 | 31497 | 46289852 |
Cardiogenic shock | 51.57 | 9.89 | 259 | 364454 | 16125 | 46305224 |
Asthenia | 50.84 | 9.89 | 2942 | 361771 | 308133 | 46013216 |
Chronic kidney disease | 49.60 | 9.89 | 513 | 364200 | 40358 | 46280991 |
Abortion induced | 49.35 | 9.89 | 10 | 364703 | 10250 | 46311099 |
Injection site bruising | 48.67 | 9.89 | 131 | 364582 | 35505 | 46285844 |
Renin increased | 47.47 | 9.89 | 24 | 364689 | 141 | 46321208 |
Renal artery stenosis | 47.39 | 9.89 | 64 | 364649 | 1724 | 46319625 |
Device dislocation | 46.70 | 9.89 | 61 | 364652 | 21741 | 46299608 |
Septic shock | 46.20 | 9.89 | 264 | 364449 | 57629 | 46263720 |
Injection site warmth | 46.11 | 9.89 | 25 | 364688 | 13747 | 46307602 |
Pulmonary oedema | 45.78 | 9.89 | 605 | 364108 | 50500 | 46270849 |
Drug dependence | 45.45 | 9.89 | 53 | 364660 | 19848 | 46301501 |
Confusional state | 45.16 | 9.89 | 1599 | 363114 | 158293 | 46163056 |
Caesarean section | 45.06 | 9.89 | 38 | 364675 | 16565 | 46304784 |
Pemphigoid | 44.62 | 9.89 | 121 | 364592 | 5570 | 46315779 |
Balance disorder | 44.49 | 9.89 | 730 | 363983 | 63791 | 46257558 |
Psoriatic arthropathy | 44.40 | 9.89 | 141 | 364572 | 36238 | 46285111 |
Drug interaction | 44.29 | 9.89 | 1975 | 362738 | 201119 | 46120230 |
Multiple sclerosis relapse | 44.23 | 9.89 | 174 | 364539 | 41951 | 46279398 |
Melaena | 43.97 | 9.89 | 369 | 364344 | 27403 | 46293946 |
Inappropriate antidiuretic hormone secretion | 43.74 | 9.89 | 222 | 364491 | 13880 | 46307469 |
Lower respiratory tract infection | 42.47 | 9.89 | 254 | 364459 | 54835 | 46266514 |
Blood glucose increased | 42.23 | 9.89 | 794 | 363919 | 71219 | 46250130 |
Transient ischaemic attack | 41.83 | 9.89 | 437 | 364276 | 34466 | 46286883 |
Oliguria | 41.83 | 9.89 | 157 | 364556 | 8602 | 46312747 |
Hyperglycaemia | 41.05 | 9.89 | 437 | 364276 | 34634 | 46286715 |
Drug withdrawal syndrome | 41.02 | 9.89 | 96 | 364617 | 27288 | 46294061 |
Rheumatoid nodule | 40.94 | 9.89 | 10 | 364703 | 9010 | 46312339 |
Atrioventricular block | 40.25 | 9.89 | 131 | 364582 | 6680 | 46314669 |
Premature labour | 40.09 | 9.89 | 19 | 364694 | 11280 | 46310069 |
Creatinine renal clearance decreased | 39.91 | 9.89 | 132 | 364581 | 6788 | 46314561 |
Oedema | 39.84 | 9.89 | 741 | 363972 | 66330 | 46255019 |
Haemorrhage subcutaneous | 39.75 | 9.89 | 77 | 364636 | 2829 | 46318520 |
Dyspnoea | 39.08 | 9.89 | 4598 | 360115 | 510950 | 45810399 |
Glomerular filtration rate decreased | 39.05 | 9.89 | 188 | 364525 | 11506 | 46309843 |
Proteinuria | 38.99 | 9.89 | 242 | 364471 | 16311 | 46305038 |
Hepatic function abnormal | 38.48 | 9.89 | 425 | 364288 | 33996 | 46287353 |
Carotid artery stenosis | 38.29 | 9.89 | 107 | 364606 | 5013 | 46316336 |
Overdose | 38.07 | 9.89 | 1055 | 363658 | 100924 | 46220425 |
Rash | 37.90 | 9.89 | 2340 | 362373 | 354172 | 45967177 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 37.83 | 9.89 | 60 | 364653 | 1875 | 46319474 |
Dehydration | 37.79 | 9.89 | 1565 | 363148 | 157975 | 46163374 |
Palpitations | 37.70 | 9.89 | 993 | 363720 | 94266 | 46227083 |
Blood pressure systolic increased | 37.66 | 9.89 | 367 | 364346 | 28420 | 46292929 |
Diabetes mellitus inadequate control | 37.52 | 9.89 | 203 | 364510 | 13011 | 46308338 |
Hemiplegia | 37.07 | 9.89 | 129 | 364584 | 6809 | 46314540 |
Seizure | 36.85 | 9.89 | 708 | 364005 | 122346 | 46199003 |
Metastases to bone | 36.31 | 9.89 | 50 | 364663 | 17426 | 46303923 |
Renal disorder | 36.29 | 9.89 | 343 | 364370 | 26343 | 46295006 |
Abdominal discomfort | 36.26 | 9.89 | 901 | 363812 | 150264 | 46171085 |
Leukopenia | 35.73 | 9.89 | 351 | 364362 | 67992 | 46253357 |
Premature baby | 35.49 | 9.89 | 54 | 364659 | 18058 | 46303291 |
Sedation complication | 35.35 | 9.89 | 84 | 364629 | 3561 | 46317788 |
Foot deformity | 34.24 | 9.89 | 42 | 364671 | 15383 | 46305966 |
Subacute cutaneous lupus erythematosus | 34.21 | 9.89 | 57 | 364656 | 1858 | 46319491 |
Distributive shock | 34.00 | 9.89 | 30 | 364683 | 491 | 46320858 |
Accidental exposure to product | 33.96 | 9.89 | 71 | 364642 | 21010 | 46300339 |
Vasodilatation | 33.61 | 9.89 | 64 | 364649 | 2321 | 46319028 |
Aortic dissection | 33.41 | 9.89 | 51 | 364662 | 1541 | 46319808 |
Hepatotoxicity | 33.35 | 9.89 | 93 | 364620 | 24916 | 46296433 |
Mood swings | 33.26 | 9.89 | 47 | 364666 | 16205 | 46305144 |
Wound | 33.17 | 9.89 | 197 | 364516 | 42605 | 46278744 |
Unintended pregnancy | 33.15 | 9.89 | 3 | 364710 | 5657 | 46315692 |
Uterine perforation | 33.10 | 9.89 | 8 | 364705 | 7259 | 46314090 |
Bladder irritation | 33.09 | 9.89 | 19 | 364694 | 149 | 46321200 |
Supraventricular extrasystoles | 32.58 | 9.89 | 88 | 364625 | 4041 | 46317308 |
Adjustment disorder | 32.49 | 9.89 | 47 | 364666 | 1352 | 46319997 |
Atrioventricular block second degree | 32.04 | 9.89 | 83 | 364630 | 3716 | 46317633 |
Stillbirth | 31.91 | 9.89 | 6 | 364707 | 6485 | 46314864 |
Ischaemic stroke | 31.90 | 9.89 | 232 | 364481 | 16490 | 46304859 |
Injection site urticaria | 31.74 | 9.89 | 28 | 364685 | 11939 | 46309410 |
Nodal rhythm | 31.70 | 9.89 | 52 | 364661 | 1673 | 46319676 |
Joint swelling | 31.41 | 9.89 | 1023 | 363690 | 165050 | 46156299 |
Blood creatine phosphokinase increased | 31.30 | 9.89 | 343 | 364370 | 27381 | 46293968 |
Intestinal malrotation | 30.93 | 9.89 | 24 | 364689 | 325 | 46321024 |
Allergic reaction to excipient | 30.61 | 9.89 | 23 | 364690 | 296 | 46321053 |
Pulmonary renal syndrome | 30.56 | 9.89 | 25 | 364688 | 367 | 46320982 |
Dysarthria | 30.36 | 9.89 | 436 | 364277 | 37062 | 46284287 |
Psychotic disorder | 30.26 | 9.89 | 84 | 364629 | 22537 | 46298812 |
Red blood cell sedimentation rate increased | 29.87 | 9.89 | 86 | 364627 | 22803 | 46298546 |
Altered state of consciousness | 29.73 | 9.89 | 296 | 364417 | 23052 | 46298297 |
Ovarian cyst | 29.57 | 9.89 | 40 | 364673 | 14047 | 46307302 |
Malaise | 29.00 | 9.89 | 2983 | 361730 | 328249 | 45993100 |
Intentional product use issue | 28.89 | 9.89 | 268 | 364445 | 52512 | 46268837 |
Hyperaldosteronism | 28.89 | 9.89 | 21 | 364692 | 256 | 46321093 |
Hyperdynamic left ventricle | 28.82 | 9.89 | 17 | 364696 | 141 | 46321208 |
Therapeutic response decreased | 28.67 | 9.89 | 208 | 364505 | 42937 | 46278412 |
Urticaria | 28.45 | 9.89 | 702 | 364011 | 117190 | 46204159 |
Colitis ulcerative | 28.33 | 9.89 | 60 | 364653 | 17672 | 46303677 |
Lacunar infarction | 28.23 | 9.89 | 75 | 364638 | 3410 | 46317939 |
Hyperuricaemia | 28.12 | 9.89 | 91 | 364622 | 4626 | 46316723 |
Gingival swelling | 28.03 | 9.89 | 81 | 364632 | 3869 | 46317480 |
Premature delivery | 28.02 | 9.89 | 84 | 364629 | 21985 | 46299364 |
Urine output decreased | 27.89 | 9.89 | 165 | 364548 | 10932 | 46310417 |
Glomerulonephritis rapidly progressive | 27.86 | 9.89 | 31 | 364682 | 680 | 46320669 |
Tenosynovitis | 27.66 | 9.89 | 12 | 364701 | 7503 | 46313846 |
Mucosal inflammation | 27.32 | 9.89 | 185 | 364528 | 38791 | 46282558 |
Cholecystitis chronic | 27.32 | 9.89 | 25 | 364688 | 10474 | 46310875 |
Hypoglycaemic coma | 26.81 | 9.89 | 61 | 364652 | 2513 | 46318836 |
Bone marrow failure | 26.62 | 9.89 | 130 | 364583 | 29539 | 46291810 |
Anaphylactic reaction | 26.42 | 9.89 | 276 | 364437 | 52836 | 46268513 |
Multiple sclerosis | 26.28 | 9.89 | 102 | 364611 | 24689 | 46296660 |
Arrhythmia | 26.20 | 9.89 | 400 | 364313 | 34441 | 46286908 |
Discomfort | 25.97 | 9.89 | 236 | 364477 | 46434 | 46274915 |
Chronic pigmented purpura | 25.94 | 9.89 | 12 | 364701 | 56 | 46321293 |
Drug level increased | 25.56 | 9.89 | 238 | 364475 | 18203 | 46303146 |
Nocturia | 25.53 | 9.89 | 117 | 364596 | 7015 | 46314334 |
Metabolic alkalosis | 25.47 | 9.89 | 61 | 364652 | 2599 | 46318750 |
Gingival bleeding | 25.46 | 9.89 | 167 | 364546 | 11472 | 46309877 |
Loose tooth | 25.46 | 9.89 | 69 | 364644 | 3175 | 46318174 |
Anaemia | 25.38 | 9.89 | 2324 | 362389 | 253455 | 46067894 |
Parkinsonism | 25.27 | 9.89 | 126 | 364587 | 7822 | 46313527 |
Bundle branch block right | 25.23 | 9.89 | 89 | 364624 | 4730 | 46316619 |
Bone erosion | 25.16 | 9.89 | 22 | 364691 | 9421 | 46311928 |
Pathogen resistance | 25.12 | 9.89 | 8 | 364705 | 6052 | 46315297 |
Sinus arrest | 25.08 | 9.89 | 47 | 364666 | 1684 | 46319665 |
Foetal death | 24.99 | 9.89 | 19 | 364694 | 8724 | 46312625 |
Angina unstable | 24.95 | 9.89 | 121 | 364592 | 7427 | 46313922 |
Acute myeloid leukaemia | 24.70 | 9.89 | 54 | 364659 | 15724 | 46305625 |
Device issue | 24.69 | 9.89 | 77 | 364636 | 19903 | 46301446 |
Amenorrhoea | 24.58 | 9.89 | 20 | 364693 | 8875 | 46312474 |
Product label on wrong product | 24.55 | 9.89 | 7 | 364706 | 3 | 46321346 |
Joint effusion | 24.24 | 9.89 | 35 | 364678 | 11960 | 46309389 |
Lip swelling | 24.15 | 9.89 | 304 | 364409 | 25091 | 46296258 |
Haematotoxicity | 24.08 | 9.89 | 12 | 364701 | 6921 | 46314428 |
Nephrosclerosis | 23.97 | 9.89 | 34 | 364679 | 960 | 46320389 |
Immunodeficiency | 23.87 | 9.89 | 41 | 364672 | 13065 | 46308284 |
Suicidal ideation | 23.76 | 9.89 | 304 | 364409 | 56078 | 46265271 |
Glycosylated haemoglobin increased | 23.76 | 9.89 | 156 | 364557 | 10720 | 46310629 |
No adverse event | 23.74 | 9.89 | 163 | 364550 | 34068 | 46287281 |
Hip arthroplasty | 23.67 | 9.89 | 68 | 364645 | 18044 | 46303305 |
Generalised tonic-clonic seizure | 23.67 | 9.89 | 120 | 364593 | 27002 | 46294347 |
Gastrointestinal haemorrhage | 23.63 | 9.89 | 781 | 363932 | 76592 | 46244757 |
Body temperature increased | 23.44 | 9.89 | 107 | 364606 | 24754 | 46296595 |
Device difficult to use | 23.39 | 9.89 | 17 | 364696 | 7987 | 46313362 |
Hypomagnesaemia | 23.36 | 9.89 | 271 | 364442 | 21939 | 46299410 |
Chest pain | 23.31 | 9.89 | 1638 | 363075 | 174686 | 46146663 |
Wrong technique in product usage process | 23.10 | 9.89 | 293 | 364420 | 54129 | 46267220 |
Irritability | 23.08 | 9.89 | 132 | 364581 | 28814 | 46292535 |
Personality disorder | 22.97 | 9.89 | 65 | 364648 | 3068 | 46318281 |
Panniculitis | 22.82 | 9.89 | 8 | 364705 | 5696 | 46315653 |
Osteopenia | 22.67 | 9.89 | 63 | 364650 | 16898 | 46304451 |
Impaired healing | 22.59 | 9.89 | 181 | 364532 | 36562 | 46284787 |
Staphylococcal infection | 22.56 | 9.89 | 175 | 364538 | 35596 | 46285753 |
Ischaemia | 22.55 | 9.89 | 81 | 364632 | 4343 | 46317006 |
Blood pressure abnormal | 22.45 | 9.89 | 168 | 364545 | 12049 | 46309300 |
Suicide attempt | 22.43 | 9.89 | 576 | 364137 | 54460 | 46266889 |
Injection site haemorrhage | 22.08 | 9.89 | 85 | 364628 | 20624 | 46300725 |
Blood potassium decreased | 22.07 | 9.89 | 419 | 364294 | 37644 | 46283705 |
Conjoined twins | 22.07 | 9.89 | 18 | 364695 | 263 | 46321086 |
Listless | 22.06 | 9.89 | 49 | 364664 | 1986 | 46319363 |
Scleral discolouration | 21.81 | 9.89 | 20 | 364693 | 345 | 46321004 |
Injection site rash | 21.69 | 9.89 | 58 | 364655 | 15755 | 46305594 |
Sleep disorder due to general medical condition, insomnia type | 21.63 | 9.89 | 7 | 364706 | 5242 | 46316107 |
Myocardial depression | 21.38 | 9.89 | 23 | 364690 | 485 | 46320864 |
Labile hypertension | 21.38 | 9.89 | 23 | 364690 | 485 | 46320864 |
Harlequin syndrome | 21.34 | 9.89 | 9 | 364704 | 32 | 46321317 |
Lichen nitidus | 21.17 | 9.89 | 11 | 364702 | 69 | 46321280 |
Folliculitis | 21.15 | 9.89 | 11 | 364702 | 6192 | 46315157 |
Hyperkaliuria | 21.07 | 9.89 | 10 | 364703 | 50 | 46321299 |
Blood potassium increased | 21.07 | 9.89 | 214 | 364499 | 16753 | 46304596 |
Ill-defined disorder | 21.04 | 9.89 | 123 | 364590 | 26704 | 46294645 |
Injury | 21.01 | 9.89 | 231 | 364482 | 43796 | 46277553 |
Status epilepticus | 20.94 | 9.89 | 49 | 364664 | 13930 | 46307419 |
Unintentional medical device removal | 20.76 | 9.89 | 5 | 364708 | 4548 | 46316801 |
Taste disorder | 20.72 | 9.89 | 96 | 364617 | 5782 | 46315567 |
Lymphocele | 20.71 | 9.89 | 29 | 364684 | 809 | 46320540 |
Gangrene | 20.65 | 9.89 | 82 | 364631 | 4613 | 46316736 |
Tubulointerstitial nephritis | 20.57 | 9.89 | 191 | 364522 | 14597 | 46306752 |
Lymphocyte stimulation test positive | 20.55 | 9.89 | 25 | 364688 | 605 | 46320744 |
Schizophrenia | 20.46 | 9.89 | 22 | 364691 | 8546 | 46312803 |
Swelling | 20.32 | 9.89 | 781 | 363932 | 123730 | 46197619 |
Gallbladder adenocarcinoma | 20.31 | 9.89 | 11 | 364702 | 76 | 46321273 |
Gestational diabetes | 20.24 | 9.89 | 16 | 364697 | 7203 | 46314146 |
Suspected suicide | 20.18 | 9.89 | 81 | 364632 | 4580 | 46316769 |
Blood aldosterone increased | 20.16 | 9.89 | 14 | 364699 | 158 | 46321191 |
Retinal ischaemia | 20.13 | 9.89 | 18 | 364695 | 300 | 46321049 |
Generalised oedema | 20.04 | 9.89 | 186 | 364527 | 14213 | 46307136 |
Faeces discoloured | 20.03 | 9.89 | 210 | 364503 | 16577 | 46304772 |
Ear infection | 19.98 | 9.89 | 102 | 364611 | 22911 | 46298438 |
Premature rupture of membranes | 19.89 | 9.89 | 5 | 364708 | 4418 | 46316931 |
Loss of consciousness | 19.84 | 9.89 | 1035 | 363678 | 107203 | 46214146 |
Galactorrhoea | 19.79 | 9.89 | 3 | 364710 | 3794 | 46317555 |
Arteriosclerosis | 19.70 | 9.89 | 137 | 364576 | 9596 | 46311753 |
Diabetic nephropathy | 19.64 | 9.89 | 37 | 364676 | 1331 | 46320018 |
Retinopathy hypertensive | 19.61 | 9.89 | 16 | 364697 | 234 | 46321115 |
Psoriasis | 19.52 | 9.89 | 466 | 364247 | 78138 | 46243211 |
Influenza like illness | 19.51 | 9.89 | 324 | 364389 | 57246 | 46264103 |
Hypertensive heart disease | 19.40 | 9.89 | 54 | 364659 | 2524 | 46318825 |
Tongue oedema | 19.29 | 9.89 | 72 | 364641 | 3934 | 46317415 |
Gingival atrophy | 19.28 | 9.89 | 8 | 364705 | 27 | 46321322 |
Aortic aneurysm | 19.24 | 9.89 | 65 | 364648 | 3379 | 46317970 |
Bradyarrhythmia | 19.21 | 9.89 | 46 | 364667 | 1960 | 46319389 |
Neurotoxicity | 19.05 | 9.89 | 50 | 364663 | 13667 | 46307682 |
Gastric ulcer haemorrhage | 19.04 | 9.89 | 82 | 364631 | 4786 | 46316563 |
Duodenal ulcer perforation | 19.03 | 9.89 | 23 | 364690 | 8479 | 46312870 |
Ageusia | 19.00 | 9.89 | 154 | 364559 | 11318 | 46310031 |
Crohn's disease | 18.99 | 9.89 | 15 | 364698 | 6756 | 46314593 |
Sickle cell anaemia with crisis | 18.97 | 9.89 | 4 | 364709 | 3988 | 46317361 |
Transcription medication error | 18.90 | 9.89 | 14 | 364699 | 176 | 46321173 |
Death | 18.89 | 9.89 | 2314 | 362399 | 333234 | 45988115 |
Peripheral swelling | 18.62 | 9.89 | 1455 | 363258 | 156616 | 46164733 |
Acute coronary syndrome | 18.57 | 9.89 | 140 | 364573 | 10064 | 46311285 |
Pollakiuria | 18.42 | 9.89 | 279 | 364434 | 23982 | 46297367 |
Agitation | 18.41 | 9.89 | 313 | 364400 | 55102 | 46266247 |
Ventricular failure | 18.14 | 9.89 | 18 | 364695 | 344 | 46321005 |
Hypocalcaemia | 18.07 | 9.89 | 302 | 364411 | 26483 | 46294866 |
Oral discharge | 18.05 | 9.89 | 13 | 364700 | 156 | 46321193 |
Complication of device insertion | 18.03 | 9.89 | 8 | 364705 | 4936 | 46316413 |
Urine albumin/creatinine ratio increased | 17.92 | 9.89 | 13 | 364700 | 158 | 46321191 |
Product substitution issue | 17.91 | 9.89 | 188 | 364525 | 14843 | 46306506 |
Skin weeping | 17.91 | 9.89 | 15 | 364698 | 228 | 46321121 |
Rectourethral fistula | 17.88 | 9.89 | 8 | 364705 | 34 | 46321315 |
C-reactive protein increased | 17.86 | 9.89 | 336 | 364377 | 58254 | 46263095 |
Dyspnoea exertional | 17.84 | 9.89 | 517 | 364196 | 49772 | 46271577 |
Drug hypersensitivity | 17.80 | 9.89 | 1651 | 363062 | 242174 | 46079175 |
Prescription drug used without a prescription | 17.79 | 9.89 | 36 | 364677 | 1366 | 46319983 |
Device deployment issue | 17.73 | 9.89 | 3 | 364710 | 3500 | 46317849 |
Upper respiratory tract infection | 17.71 | 9.89 | 370 | 364343 | 63186 | 46258163 |
Acute motor-sensory axonal neuropathy | 17.65 | 9.89 | 18 | 364695 | 356 | 46320993 |
Respiratory failure | 17.65 | 9.89 | 908 | 363805 | 93908 | 46227441 |
Mydriasis | 17.46 | 9.89 | 35 | 364678 | 10518 | 46310831 |
Gastrointestinal toxicity | 17.46 | 9.89 | 6 | 364707 | 4325 | 46317024 |
Aggression | 17.45 | 9.89 | 105 | 364608 | 22639 | 46298710 |
Dysgeusia | 17.45 | 9.89 | 427 | 364286 | 40064 | 46281285 |
Pseudolymphoma | 17.44 | 9.89 | 23 | 364690 | 605 | 46320744 |
Myocardial ischaemia | 17.40 | 9.89 | 164 | 364549 | 12585 | 46308764 |
Cytomegalovirus infection | 17.16 | 9.89 | 78 | 364635 | 18066 | 46303283 |
Maternal drugs affecting foetus | 17.09 | 9.89 | 11 | 364702 | 5507 | 46315842 |
Pancreatic toxicity | 17.01 | 9.89 | 7 | 364706 | 23 | 46321326 |
Autoimmune enteropathy | 16.97 | 9.89 | 5 | 364708 | 3 | 46321346 |
Venoocclusive liver disease | 16.94 | 9.89 | 6 | 364707 | 4245 | 46317104 |
Vitello-intestinal duct remnant | 16.86 | 9.89 | 8 | 364705 | 40 | 46321309 |
Vaginal haemorrhage | 16.74 | 9.89 | 124 | 364589 | 25480 | 46295869 |
Hypoperfusion | 16.70 | 9.89 | 35 | 364678 | 1362 | 46319987 |
Myalgia | 16.70 | 9.89 | 1146 | 363567 | 121942 | 46199407 |
Haematemesis | 16.67 | 9.89 | 317 | 364396 | 28489 | 46292860 |
Heart rate decreased | 16.64 | 9.89 | 344 | 364369 | 31379 | 46289970 |
Fryns syndrome | 16.63 | 9.89 | 9 | 364704 | 62 | 46321287 |
Congenital bladder anomaly | 16.63 | 9.89 | 13 | 364700 | 178 | 46321171 |
Head discomfort | 16.63 | 9.89 | 138 | 364575 | 10213 | 46311136 |
Benign neoplasm of adrenal gland | 16.58 | 9.89 | 7 | 364706 | 25 | 46321324 |
Haemodialysis | 16.51 | 9.89 | 126 | 364587 | 9091 | 46312258 |
Menstruation irregular | 16.51 | 9.89 | 16 | 364697 | 6523 | 46314826 |
Thrombocytopenia | 16.50 | 9.89 | 814 | 363899 | 125767 | 46195582 |
Lichen planus | 16.45 | 9.89 | 41 | 364672 | 1792 | 46319557 |
Therapy partial responder | 16.42 | 9.89 | 8 | 364705 | 4674 | 46316675 |
Urachal abnormality | 16.40 | 9.89 | 13 | 364700 | 182 | 46321167 |
Dermatosis | 16.37 | 9.89 | 16 | 364697 | 300 | 46321049 |
Fear of injection | 16.28 | 9.89 | 6 | 364707 | 4141 | 46317208 |
Putamen haemorrhage | 16.26 | 9.89 | 12 | 364701 | 150 | 46321199 |
Post transplant lymphoproliferative disorder | 16.15 | 9.89 | 5 | 364708 | 3851 | 46317498 |
Nephrogenic systemic fibrosis | 16.14 | 9.89 | 77 | 364636 | 4695 | 46316654 |
Multiple drug therapy | 16.12 | 9.89 | 27 | 364686 | 884 | 46320465 |
Rectal ulcer haemorrhage | 16.11 | 9.89 | 13 | 364700 | 187 | 46321162 |
Nodule | 16.04 | 9.89 | 65 | 364648 | 15540 | 46305809 |
Carotid arteriosclerosis | 15.97 | 9.89 | 28 | 364685 | 952 | 46320397 |
Febrile bone marrow aplasia | 15.97 | 9.89 | 18 | 364695 | 6844 | 46314505 |
Fibromuscular dysplasia | 15.95 | 9.89 | 9 | 364704 | 68 | 46321281 |
Feeling abnormal | 15.87 | 9.89 | 1158 | 363555 | 123902 | 46197447 |
Haematochezia | 15.74 | 9.89 | 394 | 364319 | 37099 | 46284250 |
Hallucination, gustatory | 15.74 | 9.89 | 9 | 364704 | 70 | 46321279 |
Intestinal villi atrophy | 15.62 | 9.89 | 12 | 364701 | 160 | 46321189 |
Product storage error | 15.61 | 9.89 | 44 | 364669 | 11748 | 46309601 |
Hyperplastic cholecystopathy | 15.57 | 9.89 | 10 | 364703 | 98 | 46321251 |
Ventricular septal defect | 15.56 | 9.89 | 6 | 364707 | 4028 | 46317321 |
CD30 expression | 15.42 | 9.89 | 7 | 364706 | 31 | 46321318 |
Persistent cloaca | 15.39 | 9.89 | 13 | 364700 | 200 | 46321149 |
Helicobacter infection | 15.38 | 9.89 | 44 | 364669 | 11692 | 46309657 |
Lymphocyte count decreased | 15.30 | 9.89 | 127 | 364586 | 25462 | 46295887 |
Swelling face | 15.29 | 9.89 | 532 | 364181 | 52527 | 46268822 |
Subdural haematoma | 15.23 | 9.89 | 162 | 364551 | 12835 | 46308514 |
Hypergastrinaemia | 15.16 | 9.89 | 10 | 364703 | 103 | 46321246 |
Presyncope | 15.15 | 9.89 | 272 | 364441 | 24182 | 46297167 |
Inflammation | 15.10 | 9.89 | 279 | 364434 | 48502 | 46272847 |
Cystic fibrosis | 15.06 | 9.89 | 5 | 364708 | 3683 | 46317666 |
Eating disorder | 15.05 | 9.89 | 178 | 364535 | 14476 | 46306873 |
Sinus rhythm | 15.05 | 9.89 | 21 | 364692 | 584 | 46320765 |
Aspergillus infection | 15.04 | 9.89 | 19 | 364694 | 6871 | 46314478 |
Enthesopathy | 15.01 | 9.89 | 9 | 364704 | 4681 | 46316668 |
Disorientation | 14.93 | 9.89 | 386 | 364327 | 36532 | 46284817 |
Soft tissue disorder | 14.91 | 9.89 | 7 | 364706 | 4179 | 46317170 |
Blood cholinesterase decreased | 14.87 | 9.89 | 11 | 364702 | 138 | 46321211 |
Cytokine release syndrome | 14.83 | 9.89 | 16 | 364697 | 6207 | 46315142 |
Substance abuse | 14.80 | 9.89 | 7 | 364706 | 4160 | 46317189 |
Acne | 14.74 | 9.89 | 93 | 364620 | 19826 | 46301523 |
Hypernatraemia | 14.71 | 9.89 | 93 | 364620 | 6308 | 46315041 |
Blood glucose decreased | 14.63 | 9.89 | 218 | 364495 | 18674 | 46302675 |
Device use error | 14.58 | 9.89 | 11 | 364702 | 5070 | 46316279 |
Retroperitoneal oedema | 14.52 | 9.89 | 6 | 364707 | 20 | 46321329 |
Weight increased | 14.51 | 9.89 | 1097 | 363616 | 163376 | 46157973 |
Bursitis | 14.50 | 9.89 | 93 | 364620 | 19749 | 46301600 |
Infected dermal cyst | 14.47 | 9.89 | 18 | 364695 | 446 | 46320903 |
Dysphoria | 14.41 | 9.89 | 9 | 364704 | 4580 | 46316769 |
Osteonecrosis | 14.40 | 9.89 | 130 | 364583 | 25614 | 46295735 |
Blood uric acid increased | 14.36 | 9.89 | 68 | 364645 | 4133 | 46317216 |
Tendonitis | 14.34 | 9.89 | 60 | 364653 | 14217 | 46307132 |
Nephrogenic anaemia | 14.33 | 9.89 | 40 | 364673 | 1873 | 46319476 |
Dementia | 14.31 | 9.89 | 179 | 364534 | 14751 | 46306598 |
Osteoporosis | 14.27 | 9.89 | 227 | 364486 | 40381 | 46280968 |
Renal cell carcinoma | 14.15 | 9.89 | 60 | 364653 | 3478 | 46317871 |
Apical granuloma | 14.15 | 9.89 | 7 | 364706 | 39 | 46321310 |
Acute hepatic failure | 14.09 | 9.89 | 63 | 364650 | 14658 | 46306691 |
Breast cancer metastatic | 14.04 | 9.89 | 57 | 364656 | 13621 | 46307728 |
Hypertensive angiopathy | 14.03 | 9.89 | 9 | 364704 | 88 | 46321261 |
Respiratory tract infection | 14.00 | 9.89 | 158 | 364555 | 29814 | 46291535 |
Kidney fibrosis | 13.99 | 9.89 | 33 | 364680 | 1392 | 46319957 |
Gout | 13.99 | 9.89 | 143 | 364570 | 11213 | 46310136 |
Secondary hypertension | 13.96 | 9.89 | 10 | 364703 | 119 | 46321230 |
Lymphadenopathy | 13.95 | 9.89 | 181 | 364532 | 33307 | 46288042 |
Microalbuminuria | 13.92 | 9.89 | 15 | 364698 | 317 | 46321032 |
Sinus arrhythmia | 13.91 | 9.89 | 32 | 364681 | 1328 | 46320021 |
Bromhidrosis | 13.89 | 9.89 | 5 | 364708 | 10 | 46321339 |
Electrocardiogram U wave present | 13.86 | 9.89 | 9 | 364704 | 90 | 46321259 |
Congenital nail disorder | 13.78 | 9.89 | 9 | 364704 | 91 | 46321258 |
Peripheral arterial occlusive disease | 13.76 | 9.89 | 62 | 364651 | 3690 | 46317659 |
Organ failure | 13.70 | 9.89 | 47 | 364666 | 2463 | 46318886 |
Pulmonary hypoplasia | 13.64 | 9.89 | 14 | 364699 | 279 | 46321070 |
Muscle spasms | 13.64 | 9.89 | 1128 | 363585 | 121985 | 46199364 |
Bowel movement irregularity | 13.63 | 9.89 | 58 | 364655 | 3367 | 46317982 |
Transplant dysfunction | 13.61 | 9.89 | 10 | 364703 | 4672 | 46316677 |
Congenital acrochordon | 13.60 | 9.89 | 8 | 364705 | 66 | 46321283 |
Gingivitis | 13.58 | 9.89 | 103 | 364610 | 7417 | 46313932 |
Herpes zoster | 13.56 | 9.89 | 415 | 364298 | 67457 | 46253892 |
Carcinoid tumour of the caecum | 13.50 | 9.89 | 6 | 364707 | 25 | 46321324 |
Platelet aggregation decreased | 13.50 | 9.89 | 6 | 364707 | 25 | 46321324 |
Burn oesophageal | 13.47 | 9.89 | 11 | 364702 | 161 | 46321188 |
Product monitoring error | 13.46 | 9.89 | 40 | 364673 | 1941 | 46319408 |
Genital haemorrhage | 13.43 | 9.89 | 19 | 364694 | 6547 | 46314802 |
Insulin-like growth factor decreased | 13.42 | 9.89 | 16 | 364697 | 379 | 46320970 |
Hypothermia | 13.42 | 9.89 | 150 | 364563 | 12033 | 46309316 |
Yellow skin | 13.39 | 9.89 | 41 | 364672 | 2023 | 46319326 |
Hypertensive encephalopathy | 13.39 | 9.89 | 21 | 364692 | 650 | 46320699 |
Cerebral ischaemia | 13.38 | 9.89 | 90 | 364623 | 6235 | 46315114 |
Thalamus haemorrhage | 13.36 | 9.89 | 19 | 364694 | 538 | 46320811 |
Skin tightness | 13.30 | 9.89 | 63 | 364650 | 3830 | 46317519 |
Ankylosing spondylitis | 13.28 | 9.89 | 20 | 364693 | 6717 | 46314632 |
Abnormal loss of weight | 13.17 | 9.89 | 75 | 364638 | 4900 | 46316449 |
Drug screen positive | 13.12 | 9.89 | 7 | 364706 | 3884 | 46317465 |
Suspected product quality issue | 13.09 | 9.89 | 11 | 364702 | 168 | 46321181 |
Small for dates baby | 13.08 | 9.89 | 6 | 364707 | 3631 | 46317718 |
Joint stiffness | 13.02 | 9.89 | 142 | 364571 | 26966 | 46294383 |
Norepinephrine increased | 13.02 | 9.89 | 8 | 364705 | 72 | 46321277 |
Knee arthroplasty | 13.02 | 9.89 | 120 | 364593 | 23545 | 46297804 |
Facial nerve disorder | 13.00 | 9.89 | 19 | 364694 | 552 | 46320797 |
Albuminuria | 12.99 | 9.89 | 12 | 364701 | 209 | 46321140 |
Blood calcium decreased | 12.99 | 9.89 | 183 | 364530 | 15490 | 46305859 |
Stomatitis haemorrhagic | 12.97 | 9.89 | 6 | 364707 | 28 | 46321321 |
Gastrointestinal ischaemia | 12.95 | 9.89 | 12 | 364701 | 210 | 46321139 |
Device malfunction | 12.94 | 9.89 | 57 | 364656 | 13317 | 46308032 |
Tonsillar inflammation | 12.93 | 9.89 | 9 | 364704 | 102 | 46321247 |
Incorrect route of product administration | 12.91 | 9.89 | 75 | 364638 | 16308 | 46305041 |
Anorexia nervosa | 12.82 | 9.89 | 11 | 364702 | 173 | 46321176 |
Saliva discolouration | 12.80 | 9.89 | 6 | 364707 | 29 | 46321320 |
Cardiac failure chronic | 12.75 | 9.89 | 58 | 364655 | 3466 | 46317883 |
Venous aneurysm | 12.70 | 9.89 | 4 | 364709 | 4 | 46321345 |
Oropharyngeal swelling | 12.67 | 9.89 | 24 | 364689 | 867 | 46320482 |
Intentional product misuse | 12.65 | 9.89 | 276 | 364437 | 46852 | 46274497 |
Jaundice hepatocellular | 12.64 | 9.89 | 6 | 364707 | 30 | 46321319 |
Femoral artery dissection | 12.64 | 9.89 | 6 | 364707 | 30 | 46321319 |
Mania | 12.57 | 9.89 | 43 | 364670 | 10803 | 46310546 |
Transplant rejection | 12.56 | 9.89 | 36 | 364677 | 9560 | 46311789 |
Duodenal ulcer | 12.56 | 9.89 | 98 | 364615 | 7120 | 46314229 |
Urinary retention | 12.51 | 9.89 | 279 | 364434 | 25782 | 46295567 |
Gravitational oedema | 12.51 | 9.89 | 27 | 364686 | 1073 | 46320276 |
Psychogenic visual disorder | 12.49 | 9.89 | 5 | 364708 | 15 | 46321334 |
Hypoglossal nerve paralysis | 12.49 | 9.89 | 5 | 364708 | 15 | 46321334 |
Diverticulum intestinal haemorrhagic | 12.44 | 9.89 | 29 | 364684 | 1214 | 46320135 |
Haemodynamic instability | 12.41 | 9.89 | 103 | 364610 | 7622 | 46313727 |
Capillary disorder | 12.41 | 9.89 | 8 | 364705 | 79 | 46321270 |
Tuberculosis | 12.37 | 9.89 | 40 | 364673 | 10225 | 46311124 |
Injection site induration | 12.36 | 9.89 | 28 | 364685 | 8051 | 46313298 |
Adenoma benign | 12.33 | 9.89 | 21 | 364692 | 697 | 46320652 |
Psychomotor retardation | 12.29 | 9.89 | 54 | 364659 | 3179 | 46318170 |
Immune reconstitution inflammatory syndrome | 12.28 | 9.89 | 16 | 364697 | 5709 | 46315640 |
Fatigue | 12.26 | 9.89 | 4420 | 360293 | 604277 | 45717072 |
Blood cholinesterase increased | 12.25 | 9.89 | 5 | 364708 | 16 | 46321333 |
Acral lentiginous melanoma | 12.24 | 9.89 | 4 | 364709 | 5 | 46321344 |
Device breakage | 12.22 | 9.89 | 37 | 364676 | 9655 | 46311694 |
Nephrolithiasis | 12.21 | 9.89 | 183 | 364530 | 32868 | 46288481 |
Blood loss anaemia | 12.14 | 9.89 | 111 | 364602 | 8446 | 46312903 |
Renal tubular necrosis | 12.09 | 9.89 | 133 | 364580 | 10626 | 46310723 |
Electrocardiogram abnormal | 12.09 | 9.89 | 95 | 364618 | 6917 | 46314432 |
Duodenal ulcer repair | 12.08 | 9.89 | 7 | 364706 | 56 | 46321293 |
Bifascicular block | 12.03 | 9.89 | 9 | 364704 | 115 | 46321234 |
Biopsy kidney | 12.03 | 9.89 | 9 | 364704 | 115 | 46321234 |
Thirst | 12.03 | 9.89 | 135 | 364578 | 10841 | 46310508 |
Atrial pressure increased | 12.02 | 9.89 | 5 | 364708 | 17 | 46321332 |
Gastric cancer | 11.97 | 9.89 | 50 | 364663 | 2879 | 46318470 |
Gastrointestinal disorder | 11.97 | 9.89 | 364 | 364349 | 59212 | 46262137 |
Hypomania | 11.96 | 9.89 | 10 | 364703 | 4378 | 46316971 |
Hyperprolactinaemia | 11.93 | 9.89 | 4 | 364709 | 2928 | 46318421 |
Cerebral haemorrhage | 11.87 | 9.89 | 298 | 364415 | 28073 | 46293276 |
Dry eye | 11.86 | 9.89 | 166 | 364547 | 30156 | 46291193 |
Accelerated hypertension | 11.84 | 9.89 | 15 | 364698 | 379 | 46320970 |
Ischaemic cardiomyopathy | 11.82 | 9.89 | 46 | 364667 | 2564 | 46318785 |
Hypereosinophilic syndrome | 11.78 | 9.89 | 12 | 364701 | 237 | 46321112 |
Cytotoxic oedema | 11.78 | 9.89 | 9 | 364704 | 119 | 46321230 |
Fungal infection | 11.77 | 9.89 | 161 | 364552 | 29359 | 46291990 |
Ear pain | 11.73 | 9.89 | 113 | 364600 | 21979 | 46299370 |
Candida infection | 11.71 | 9.89 | 114 | 364599 | 22126 | 46299223 |
Congenital diaphragmatic hernia | 11.71 | 9.89 | 11 | 364702 | 196 | 46321153 |
Cognitive disorder | 11.70 | 9.89 | 374 | 364339 | 36509 | 46284840 |
Periodontitis | 11.69 | 9.89 | 56 | 364657 | 3420 | 46317929 |
Bladder sphincter atony | 11.67 | 9.89 | 10 | 364703 | 157 | 46321192 |
Tachypnoea | 11.67 | 9.89 | 167 | 364546 | 14184 | 46307165 |
Normal newborn | 11.65 | 9.89 | 18 | 364695 | 5983 | 46315366 |
Enterochromaffin cell hyperplasia | 11.58 | 9.89 | 7 | 364706 | 61 | 46321288 |
Sinus node dysfunction | 11.58 | 9.89 | 65 | 364648 | 4224 | 46317125 |
Adrenal neoplasm | 11.58 | 9.89 | 13 | 364700 | 288 | 46321061 |
Cardiac index increased | 11.58 | 9.89 | 3 | 364710 | 0 | 46321349 |
Blood pressure difference of extremities | 11.58 | 9.89 | 3 | 364710 | 0 | 46321349 |
Tongue abscess | 11.58 | 9.89 | 3 | 364710 | 0 | 46321349 |
Ventricular drainage | 11.58 | 9.89 | 3 | 364710 | 0 | 46321349 |
Herpes zoster reactivation | 11.58 | 9.89 | 3 | 364710 | 0 | 46321349 |
Morganella test positive | 11.58 | 9.89 | 3 | 364710 | 0 | 46321349 |
Carbohydrate metabolism disorder | 11.58 | 9.89 | 3 | 364710 | 0 | 46321349 |
Typical aura without headache | 11.58 | 9.89 | 3 | 364710 | 0 | 46321349 |
Diabetes mellitus | 11.58 | 9.89 | 490 | 364223 | 49575 | 46271774 |
Retroperitoneal haematoma | 11.53 | 9.89 | 46 | 364667 | 2594 | 46318755 |
Finger deformity | 11.52 | 9.89 | 14 | 364699 | 5148 | 46316201 |
Infusion site streaking | 11.50 | 9.89 | 14 | 364699 | 339 | 46321010 |
Hyperhidrosis | 11.50 | 9.89 | 575 | 364138 | 88733 | 46232616 |
Headache | 11.50 | 9.89 | 3449 | 361264 | 474903 | 45846446 |
Vertigo | 11.50 | 9.89 | 507 | 364206 | 51541 | 46269808 |
Intestinal ischaemia | 11.49 | 9.89 | 93 | 364620 | 6832 | 46314517 |
Clostridium difficile infection | 11.47 | 9.89 | 133 | 364580 | 24970 | 46296379 |
Protein urine present | 11.45 | 9.89 | 74 | 364639 | 5057 | 46316292 |
Ectopic pregnancy | 11.45 | 9.89 | 3 | 364710 | 2579 | 46318770 |
Mitral valve incompetence | 11.44 | 9.89 | 209 | 364504 | 18643 | 46302706 |
Leukaemic infiltration renal | 11.41 | 9.89 | 5 | 364708 | 20 | 46321329 |
Renal function test abnormal | 11.38 | 9.89 | 47 | 364666 | 2692 | 46318657 |
Dialysis | 11.35 | 9.89 | 125 | 364588 | 9991 | 46311358 |
Vasculitis | 11.32 | 9.89 | 160 | 364553 | 13551 | 46307798 |
Disability | 11.32 | 9.89 | 41 | 364672 | 10126 | 46311223 |
Neurosensory hypoacusis | 11.30 | 9.89 | 13 | 364700 | 296 | 46321053 |
Hypertonic bladder | 11.29 | 9.89 | 50 | 364663 | 2954 | 46318395 |
Cerebrovascular insufficiency | 11.25 | 9.89 | 8 | 364705 | 94 | 46321255 |
Deformity | 11.22 | 9.89 | 25 | 364688 | 7232 | 46314117 |
Central nervous system lesion | 11.22 | 9.89 | 38 | 364675 | 9577 | 46311772 |
Acute graft versus host disease | 11.21 | 9.89 | 9 | 364704 | 4021 | 46317328 |
Wrong drug | 11.18 | 9.89 | 9 | 364704 | 129 | 46321220 |
Tracheo-oesophageal fistula | 11.18 | 9.89 | 17 | 364696 | 512 | 46320837 |
Arterial occlusive disease | 11.17 | 9.89 | 70 | 364643 | 4734 | 46316615 |
Fluid intake reduced | 11.15 | 9.89 | 54 | 364659 | 3312 | 46318037 |
Purpura | 11.15 | 9.89 | 123 | 364590 | 9835 | 46311514 |
Base excess decreased | 11.12 | 9.89 | 7 | 364706 | 66 | 46321283 |
Coronary arterial stent insertion | 11.11 | 9.89 | 48 | 364665 | 2805 | 46318544 |
Stress | 11.10 | 9.89 | 312 | 364401 | 51239 | 46270110 |
Drug tolerance decreased | 11.08 | 9.89 | 5 | 364708 | 3054 | 46318295 |
Small cell carcinoma | 11.07 | 9.89 | 10 | 364703 | 169 | 46321180 |
Hyperlipidaemia | 11.06 | 9.89 | 205 | 364508 | 18334 | 46303015 |
Internal haemorrhage | 11.04 | 9.89 | 66 | 364647 | 4389 | 46316960 |
Upper gastrointestinal haemorrhage | 11.02 | 9.89 | 188 | 364525 | 16550 | 46304799 |
Pulse abnormal | 10.99 | 9.89 | 33 | 364680 | 1611 | 46319738 |
Head banging | 10.97 | 9.89 | 15 | 364698 | 409 | 46320940 |
Product solubility abnormal | 10.96 | 9.89 | 22 | 364691 | 830 | 46320519 |
Anti-erythropoietin antibody positive | 10.94 | 9.89 | 15 | 364698 | 410 | 46320939 |
Pneumonia viral | 10.93 | 9.89 | 22 | 364691 | 6602 | 46314747 |
Haemoglobin decreased | 10.91 | 9.89 | 1159 | 363554 | 127790 | 46193559 |
Gastric pH increased | 10.90 | 9.89 | 6 | 364707 | 43 | 46321306 |
Pericardial effusion | 10.90 | 9.89 | 269 | 364444 | 25274 | 46296075 |
Dystonia | 10.88 | 9.89 | 48 | 364665 | 11209 | 46310140 |
Blood sodium decreased | 10.88 | 9.89 | 234 | 364479 | 21492 | 46299857 |
Acquired porphyria | 10.87 | 9.89 | 5 | 364708 | 23 | 46321326 |
Porphyrins urine increased | 10.87 | 9.89 | 5 | 364708 | 23 | 46321326 |
Hand dermatitis | 10.87 | 9.89 | 7 | 364706 | 69 | 46321280 |
Trichoglossia | 10.84 | 9.89 | 9 | 364704 | 135 | 46321214 |
Renal cyst infection | 10.84 | 9.89 | 8 | 364705 | 100 | 46321249 |
Blood sodium increased | 10.80 | 9.89 | 44 | 364669 | 2505 | 46318844 |
Mixed dementia | 10.80 | 9.89 | 4 | 364709 | 9 | 46321340 |
Renal aneurysm | 10.80 | 9.89 | 4 | 364709 | 9 | 46321340 |
Heat illness | 10.79 | 9.89 | 10 | 364703 | 175 | 46321174 |
Ventricular internal diameter abnormal | 10.78 | 9.89 | 6 | 364707 | 44 | 46321305 |
Disease progression | 10.78 | 9.89 | 593 | 364120 | 90707 | 46230642 |
Essential hypertension | 10.78 | 9.89 | 64 | 364649 | 4246 | 46317103 |
Aphasia | 10.78 | 9.89 | 296 | 364417 | 28271 | 46293078 |
Dermatitis bullous | 10.77 | 9.89 | 99 | 364614 | 7544 | 46313805 |
Optic nerve injury | 10.76 | 9.89 | 16 | 364697 | 472 | 46320877 |
Ventricular extrasystoles | 10.76 | 9.89 | 133 | 364580 | 10930 | 46310419 |
Reduced facial expression | 10.65 | 9.89 | 27 | 364686 | 1193 | 46320156 |
Drug abuser | 10.63 | 9.89 | 6 | 364707 | 3227 | 46318122 |
Granuloma skin | 10.63 | 9.89 | 7 | 364706 | 3463 | 46317886 |
Depression | 10.58 | 9.89 | 1165 | 363548 | 168939 | 46152410 |
Injection site discolouration | 10.53 | 9.89 | 24 | 364689 | 6886 | 46314463 |
Skin discolouration | 10.52 | 9.89 | 332 | 364381 | 32348 | 46289001 |
Hepatocellular carcinoma | 10.48 | 9.89 | 47 | 364666 | 2792 | 46318557 |
Surgery | 10.42 | 9.89 | 160 | 364553 | 28625 | 46292724 |
Neurofibrosarcoma | 10.42 | 9.89 | 9 | 364704 | 143 | 46321206 |
Nephrotic syndrome | 10.40 | 9.89 | 70 | 364643 | 4851 | 46316498 |
Asymptomatic bacteriuria | 10.38 | 9.89 | 7 | 364706 | 75 | 46321274 |
Pigmentation disorder | 10.36 | 9.89 | 57 | 364656 | 3676 | 46317673 |
Metastases to fallopian tube | 10.35 | 9.89 | 6 | 364707 | 48 | 46321301 |
Rales | 10.34 | 9.89 | 118 | 364595 | 9513 | 46311836 |
Haemorrhagic erosive gastritis | 10.34 | 9.89 | 12 | 364701 | 276 | 46321073 |
Pelvic pain | 10.31 | 9.89 | 51 | 364662 | 11551 | 46309798 |
Blood iron abnormal | 10.26 | 9.89 | 6 | 364707 | 3164 | 46318185 |
Cardiac valve sclerosis | 10.23 | 9.89 | 5 | 364708 | 27 | 46321322 |
Laryngeal obstruction | 10.23 | 9.89 | 5 | 364708 | 27 | 46321322 |
Embedded device | 10.20 | 9.89 | 5 | 364708 | 2911 | 46318438 |
Cerebellar haemorrhage | 10.16 | 9.89 | 28 | 364685 | 1301 | 46320048 |
Pernicious anaemia | 10.15 | 9.89 | 19 | 364694 | 680 | 46320669 |
Sleep disorder | 10.13 | 9.89 | 283 | 364430 | 46512 | 46274837 |
Lip disorder | 10.10 | 9.89 | 25 | 364688 | 1088 | 46320261 |
Cell marker increased | 10.09 | 9.89 | 13 | 364700 | 334 | 46321015 |
Pelvi-ureteric obstruction | 10.09 | 9.89 | 8 | 364705 | 112 | 46321237 |
Urate nephropathy | 10.09 | 9.89 | 8 | 364705 | 112 | 46321237 |
Oesophageal carcinoma recurrent | 10.08 | 9.89 | 5 | 364708 | 28 | 46321321 |
Grip strength decreased | 10.05 | 9.89 | 34 | 364679 | 8572 | 46312777 |
Albumin urine present | 10.04 | 9.89 | 11 | 364702 | 237 | 46321112 |
Graft versus host disease in skin | 10.04 | 9.89 | 3 | 364710 | 2364 | 46318985 |
Synovial cyst | 10.03 | 9.89 | 27 | 364686 | 7319 | 46314030 |
Blood lactic acid | 10.03 | 9.89 | 8 | 364705 | 113 | 46321236 |
Pneumothorax traumatic | 10.02 | 9.89 | 9 | 364704 | 151 | 46321198 |
Forced vital capacity decreased | 10.01 | 9.89 | 22 | 364691 | 885 | 46320464 |
Cerebrovascular disorder | 10.01 | 9.89 | 47 | 364666 | 2847 | 46318502 |
Temperature regulation disorder | 10.00 | 9.89 | 7 | 364706 | 3353 | 46317996 |
Stomatitis | 9.94 | 9.89 | 434 | 364279 | 67863 | 46253486 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 429.95 | 10.78 | 2051 | 297353 | 97441 | 29555633 |
Drug abuse | 381.95 | 10.78 | 171 | 299233 | 81901 | 29571173 |
Gingival hypertrophy | 376.44 | 10.78 | 223 | 299181 | 1410 | 29651664 |
Blood pressure inadequately controlled | 256.96 | 10.78 | 210 | 299194 | 2360 | 29650714 |
Drug ineffective | 247.39 | 10.78 | 2196 | 297208 | 338191 | 29314883 |
Hypertension | 243.57 | 10.78 | 2057 | 297347 | 119297 | 29533777 |
Off label use | 199.43 | 10.78 | 1567 | 297837 | 247723 | 29405351 |
Hypertensive crisis | 190.72 | 10.78 | 318 | 299086 | 8039 | 29645035 |
Shock | 177.91 | 10.78 | 568 | 298836 | 22291 | 29630783 |
Oedema peripheral | 177.07 | 10.78 | 1725 | 297679 | 104107 | 29548967 |
Death | 174.19 | 10.78 | 2521 | 296883 | 354762 | 29298312 |
Neutropenia | 170.25 | 10.78 | 684 | 298720 | 127856 | 29525218 |
Blood pressure increased | 155.27 | 10.78 | 1240 | 298164 | 70688 | 29582386 |
Febrile neutropenia | 154.73 | 10.78 | 547 | 298857 | 106146 | 29546928 |
Foetal exposure during pregnancy | 153.23 | 10.78 | 89 | 299315 | 36782 | 29616292 |
Angioedema | 141.12 | 10.78 | 699 | 298705 | 33685 | 29619389 |
Bradycardia | 139.98 | 10.78 | 1127 | 298277 | 64399 | 29588675 |
Acute kidney injury | 137.56 | 10.78 | 3645 | 295759 | 270197 | 29382877 |
Non-cardiogenic pulmonary oedema | 132.99 | 10.78 | 84 | 299320 | 605 | 29652469 |
Product use in unapproved indication | 130.95 | 10.78 | 344 | 299060 | 73349 | 29579725 |
Intentional overdose | 125.21 | 10.78 | 776 | 298628 | 40705 | 29612369 |
Treatment failure | 115.15 | 10.78 | 106 | 299298 | 34573 | 29618501 |
Hypotension | 113.65 | 10.78 | 2714 | 296690 | 197851 | 29455223 |
Cerebral infarction | 113.12 | 10.78 | 543 | 298861 | 25830 | 29627244 |
Syncope | 102.11 | 10.78 | 1297 | 298107 | 83606 | 29569468 |
Angina pectoris | 92.72 | 10.78 | 558 | 298846 | 28960 | 29624114 |
Rheumatoid arthritis | 87.14 | 10.78 | 175 | 299229 | 41022 | 29612052 |
Hypokalaemia | 82.77 | 10.78 | 816 | 298588 | 49376 | 29603698 |
Thrombocytopenia | 81.59 | 10.78 | 926 | 298478 | 136118 | 29516956 |
Swollen tongue | 77.69 | 10.78 | 299 | 299105 | 12893 | 29640181 |
Blood creatinine increased | 77.16 | 10.78 | 1313 | 298091 | 90062 | 29563012 |
Hyperkalaemia | 76.21 | 10.78 | 1001 | 298403 | 65009 | 29588065 |
Drug resistance | 74.94 | 10.78 | 55 | 299349 | 20078 | 29632996 |
Pancytopenia | 74.23 | 10.78 | 521 | 298883 | 84531 | 29568543 |
Lip swelling | 72.73 | 10.78 | 286 | 299118 | 12458 | 29640616 |
Aggression | 72.03 | 10.78 | 164 | 299240 | 36743 | 29616331 |
Immune reconstitution inflammatory syndrome | 71.48 | 10.78 | 5 | 299399 | 9096 | 29643978 |
Drug dependence | 70.79 | 10.78 | 65 | 299339 | 21230 | 29631844 |
Pyrexia | 70.29 | 10.78 | 2327 | 297077 | 292162 | 29360912 |
Cerebrovascular accident | 68.12 | 10.78 | 1193 | 298211 | 82284 | 29570790 |
Blood pressure systolic increased | 66.16 | 10.78 | 313 | 299091 | 14797 | 29638277 |
Premature baby | 64.22 | 10.78 | 44 | 299360 | 16647 | 29636427 |
Renal impairment | 63.03 | 10.78 | 1187 | 298217 | 82997 | 29570077 |
Seizure | 59.90 | 10.78 | 662 | 298742 | 97813 | 29555261 |
Rhabdomyolysis | 58.60 | 10.78 | 927 | 298477 | 62653 | 29590421 |
Metabolic acidosis | 58.36 | 10.78 | 602 | 298802 | 36859 | 29616215 |
Dizziness | 57.58 | 10.78 | 2439 | 296965 | 192470 | 29460604 |
Distributive shock | 56.76 | 10.78 | 49 | 299355 | 597 | 29652477 |
Infective pulmonary exacerbation of cystic fibrosis | 56.41 | 10.78 | 9 | 299395 | 8563 | 29644511 |
Sepsis | 55.53 | 10.78 | 1080 | 298324 | 145315 | 29507759 |
Pathogen resistance | 54.97 | 10.78 | 9 | 299395 | 8401 | 29644673 |
Exposure during pregnancy | 54.06 | 10.78 | 13 | 299391 | 9248 | 29643826 |
Agitation | 53.38 | 10.78 | 319 | 299085 | 53754 | 29599320 |
Mucosal inflammation | 52.88 | 10.78 | 144 | 299260 | 30350 | 29622724 |
Infusion related reaction | 51.63 | 10.78 | 219 | 299185 | 40345 | 29612729 |
Lactic acidosis | 51.21 | 10.78 | 507 | 298897 | 30706 | 29622368 |
Leukopenia | 47.04 | 10.78 | 348 | 299056 | 55811 | 29597263 |
Chronic kidney disease | 46.69 | 10.78 | 581 | 298823 | 37257 | 29615817 |
Glycosylated haemoglobin increased | 46.31 | 10.78 | 203 | 299201 | 9288 | 29643786 |
Pemphigoid | 46.29 | 10.78 | 173 | 299231 | 7355 | 29645719 |
Interstitial lung disease | 46.14 | 10.78 | 852 | 298552 | 59345 | 29593729 |
Chronic pigmented purpura | 45.02 | 10.78 | 22 | 299382 | 88 | 29652986 |
Progressive multifocal leukoencephalopathy | 44.75 | 10.78 | 17 | 299387 | 8996 | 29644078 |
Palmar-plantar erythrodysaesthesia syndrome | 43.48 | 10.78 | 276 | 299128 | 14594 | 29638480 |
Cardiac failure congestive | 42.53 | 10.78 | 1125 | 298279 | 83282 | 29569792 |
Nephrotic syndrome | 42.14 | 10.78 | 158 | 299246 | 6727 | 29646347 |
Myalgia | 41.60 | 10.78 | 1032 | 298372 | 75635 | 29577439 |
Septic shock | 41.32 | 10.78 | 421 | 298983 | 63186 | 29589888 |
Acute graft versus host disease | 41.31 | 10.78 | 5 | 299399 | 5859 | 29647215 |
Pulmonary oedema | 41.20 | 10.78 | 643 | 298761 | 43332 | 29609742 |
Abnormal behaviour | 40.07 | 10.78 | 127 | 299277 | 25496 | 29627578 |
Suicidal ideation | 40.04 | 10.78 | 205 | 299199 | 35909 | 29617165 |
Myocardial depression | 39.96 | 10.78 | 16 | 299388 | 34 | 29653040 |
Renal artery stenosis | 39.34 | 10.78 | 68 | 299336 | 1771 | 29651303 |
Multiple organ dysfunction syndrome | 39.29 | 10.78 | 425 | 298979 | 63062 | 29590012 |
Depression | 39.04 | 10.78 | 652 | 298752 | 89785 | 29563289 |
Product use issue | 38.60 | 10.78 | 285 | 299119 | 45731 | 29607343 |
Hypoglycaemia | 37.15 | 10.78 | 716 | 298688 | 50265 | 29602809 |
Gingival swelling | 37.07 | 10.78 | 54 | 299350 | 1210 | 29651864 |
Hypomagnesaemia | 36.77 | 10.78 | 288 | 299116 | 16310 | 29636764 |
Synovitis | 36.05 | 10.78 | 27 | 299377 | 9756 | 29643318 |
Diabetic nephropathy | 35.98 | 10.78 | 66 | 299338 | 1803 | 29651271 |
Suicide attempt | 35.69 | 10.78 | 540 | 298864 | 36157 | 29616917 |
Atrioventricular block complete | 35.23 | 10.78 | 173 | 299231 | 8304 | 29644770 |
Hyponatraemia | 34.80 | 10.78 | 899 | 298505 | 66303 | 29586771 |
Bone marrow failure | 34.20 | 10.78 | 167 | 299237 | 29618 | 29623456 |
5-hydroxyindolacetic acid in urine increased | 34.16 | 10.78 | 23 | 299381 | 187 | 29652887 |
Aspergillus infection | 34.16 | 10.78 | 31 | 299373 | 10183 | 29642891 |
Psychotic disorder | 34.09 | 10.78 | 106 | 299298 | 21409 | 29631665 |
Proteinuria | 34.05 | 10.78 | 277 | 299127 | 15868 | 29637206 |
Infection | 33.98 | 10.78 | 562 | 298842 | 77512 | 29575562 |
Suspected suicide | 33.74 | 10.78 | 88 | 299316 | 3073 | 29650001 |
Pseudolymphoma | 33.46 | 10.78 | 33 | 299371 | 482 | 29652592 |
Cytomegalovirus infection | 33.18 | 10.78 | 123 | 299281 | 23551 | 29629523 |
Febrile bone marrow aplasia | 32.99 | 10.78 | 20 | 299384 | 8077 | 29644997 |
Bronchopulmonary aspergillosis | 32.63 | 10.78 | 45 | 299359 | 12239 | 29640835 |
Sedation | 32.56 | 10.78 | 72 | 299332 | 16301 | 29636773 |
Drug withdrawal syndrome | 32.53 | 10.78 | 96 | 299308 | 19713 | 29633361 |
Multiple sclerosis | 32.44 | 10.78 | 16 | 299388 | 7251 | 29645823 |
Haemophagocytic lymphohistiocytosis | 32.41 | 10.78 | 30 | 299374 | 9761 | 29643313 |
Sinus bradycardia | 32.31 | 10.78 | 214 | 299190 | 11481 | 29641593 |
Cytokine release syndrome | 32.21 | 10.78 | 31 | 299373 | 9902 | 29643172 |
Peripheral swelling | 31.62 | 10.78 | 817 | 298587 | 60257 | 29592817 |
Plasma cell myeloma | 30.68 | 10.78 | 364 | 299040 | 53098 | 29599976 |
Gingival bleeding | 30.51 | 10.78 | 136 | 299268 | 6268 | 29646806 |
Tachycardia | 30.40 | 10.78 | 536 | 298868 | 73203 | 29579871 |
Periodontitis | 30.03 | 10.78 | 58 | 299346 | 1649 | 29651425 |
Thalamus haemorrhage | 29.67 | 10.78 | 42 | 299362 | 916 | 29652158 |
Coma | 29.56 | 10.78 | 260 | 299144 | 40189 | 29612885 |
Substance abuse | 29.23 | 10.78 | 17 | 299387 | 7023 | 29646051 |
Graft versus host disease | 29.22 | 10.78 | 35 | 299369 | 10115 | 29642959 |
Eczema | 29.08 | 10.78 | 231 | 299173 | 13138 | 29639936 |
Gastrointestinal tract mucosal pigmentation | 28.99 | 10.78 | 22 | 299382 | 220 | 29652854 |
Injection site pain | 28.76 | 10.78 | 181 | 299223 | 30129 | 29622945 |
Contraindicated product administered | 28.66 | 10.78 | 83 | 299321 | 17148 | 29635926 |
Alcohol abuse | 28.47 | 10.78 | 9 | 299395 | 5344 | 29647730 |
Post transplant lymphoproliferative disorder | 28.08 | 10.78 | 9 | 299395 | 5297 | 29647777 |
Heart rate decreased | 27.92 | 10.78 | 327 | 299077 | 20667 | 29632407 |
Chronic graft versus host disease | 27.85 | 10.78 | 4 | 299400 | 4115 | 29648959 |
Vertebral osteophyte | 27.80 | 10.78 | 13 | 299391 | 46 | 29653028 |
Respiratory depression | 27.78 | 10.78 | 45 | 299359 | 11458 | 29641616 |
Plasmapheresis | 27.54 | 10.78 | 25 | 299379 | 327 | 29652747 |
Vasoplegia syndrome | 27.19 | 10.78 | 47 | 299357 | 1224 | 29651850 |
Palpitations | 27.06 | 10.78 | 479 | 298925 | 33094 | 29619980 |
Transient ischaemic attack | 26.94 | 10.78 | 377 | 299027 | 24823 | 29628251 |
Staphylococcal infection | 26.90 | 10.78 | 184 | 299220 | 30040 | 29623034 |
Diabetes mellitus inadequate control | 26.40 | 10.78 | 218 | 299186 | 12544 | 29640530 |
Renal cell carcinoma | 26.38 | 10.78 | 121 | 299283 | 5645 | 29647429 |
Intentional product use issue | 26.29 | 10.78 | 235 | 299169 | 36205 | 29616869 |
Mucormycosis | 26.05 | 10.78 | 10 | 299394 | 5258 | 29647816 |
Myelodysplastic syndrome | 26.03 | 10.78 | 98 | 299306 | 18680 | 29634394 |
Nocturia | 26.01 | 10.78 | 157 | 299247 | 8155 | 29644919 |
Intentional self-injury | 25.70 | 10.78 | 61 | 299343 | 13471 | 29639603 |
Candida infection | 25.55 | 10.78 | 74 | 299330 | 15288 | 29637786 |
Polymyositis | 25.52 | 10.78 | 49 | 299355 | 1387 | 29651687 |
C-reactive protein abnormal | 25.45 | 10.78 | 12 | 299392 | 5581 | 29647493 |
Psoriatic arthropathy | 25.43 | 10.78 | 77 | 299327 | 15684 | 29637390 |
Dyskinesia | 25.31 | 10.78 | 122 | 299282 | 21712 | 29631362 |
Hyperplasia | 25.11 | 10.78 | 29 | 299375 | 512 | 29652562 |
Acute hepatic failure | 24.35 | 10.78 | 51 | 299353 | 11776 | 29641298 |
Haematotoxicity | 24.09 | 10.78 | 16 | 299388 | 6154 | 29646920 |
Primary hyperaldosteronism | 24.00 | 10.78 | 12 | 299392 | 51 | 29653023 |
Pelvic mass | 23.97 | 10.78 | 16 | 299388 | 128 | 29652946 |
Pain | 23.96 | 10.78 | 1447 | 297957 | 171194 | 29481880 |
Dystonia | 23.54 | 10.78 | 38 | 299366 | 9689 | 29643385 |
Venoocclusive liver disease | 23.42 | 10.78 | 19 | 299385 | 6594 | 29646480 |
Carotid sinus syndrome | 23.09 | 10.78 | 10 | 299394 | 28 | 29653046 |
Aortic dissection | 23.07 | 10.78 | 65 | 299339 | 2377 | 29650697 |
Maternal drugs affecting foetus | 23.06 | 10.78 | 7 | 299397 | 4266 | 29648808 |
Prerenal failure | 23.03 | 10.78 | 55 | 299349 | 1816 | 29651258 |
Atrioventricular block first degree | 22.87 | 10.78 | 115 | 299289 | 5573 | 29647501 |
Lipodystrophy acquired | 22.85 | 10.78 | 4 | 299400 | 3556 | 29649518 |
Hyperuricaemia | 22.71 | 10.78 | 139 | 299265 | 7255 | 29645819 |
Diffuse large B-cell lymphoma | 22.61 | 10.78 | 27 | 299377 | 7814 | 29645260 |
Cardiogenic shock | 22.58 | 10.78 | 263 | 299141 | 16598 | 29636476 |
Blood mercury abnormal | 22.56 | 10.78 | 17 | 299387 | 168 | 29652906 |
Osteonecrosis | 22.50 | 10.78 | 84 | 299320 | 16051 | 29637023 |
Sinusitis | 22.35 | 10.78 | 219 | 299185 | 33126 | 29619948 |
Pneumonia | 22.20 | 10.78 | 2966 | 296438 | 331340 | 29321734 |
Atrioventricular block | 21.81 | 10.78 | 136 | 299268 | 7146 | 29645928 |
Blood pressure diastolic decreased | 21.64 | 10.78 | 121 | 299283 | 6110 | 29646964 |
Wrong technique in product usage process | 21.57 | 10.78 | 203 | 299201 | 30952 | 29622122 |
Loss of consciousness | 21.52 | 10.78 | 985 | 298419 | 78390 | 29574684 |
Intentional product misuse | 21.47 | 10.78 | 232 | 299172 | 34435 | 29618639 |
Device issue | 21.40 | 10.78 | 28 | 299376 | 7788 | 29645286 |
Product monitoring error | 21.24 | 10.78 | 51 | 299353 | 1690 | 29651384 |
Peripheral arterial occlusive disease | 21.14 | 10.78 | 105 | 299299 | 5063 | 29648011 |
Brain contusion | 20.80 | 10.78 | 32 | 299372 | 754 | 29652320 |
Mouth swelling | 20.77 | 10.78 | 48 | 299356 | 1551 | 29651523 |
Orthostatic hypotension | 20.72 | 10.78 | 346 | 299058 | 23633 | 29629441 |
Multiple sclerosis relapse | 20.60 | 10.78 | 49 | 299355 | 10813 | 29642261 |
Leukaemoid reaction | 20.54 | 10.78 | 13 | 299391 | 94 | 29652980 |
Electrocardiogram QRS complex prolonged | 20.50 | 10.78 | 91 | 299313 | 4186 | 29648888 |
No adverse event | 20.38 | 10.78 | 97 | 299307 | 17322 | 29635752 |
Renal disorder | 20.27 | 10.78 | 340 | 299064 | 23244 | 29629830 |
Chills | 20.26 | 10.78 | 559 | 298845 | 71779 | 29581295 |
Disease progression | 20.17 | 10.78 | 626 | 298778 | 79248 | 29573826 |
Neutrophil count decreased | 20.00 | 10.78 | 301 | 299103 | 42153 | 29610921 |
Drug ineffective for unapproved indication | 19.91 | 10.78 | 50 | 299354 | 10830 | 29642244 |
Dermatomyositis | 19.86 | 10.78 | 37 | 299367 | 1023 | 29652051 |
Lacunar infarction | 19.81 | 10.78 | 73 | 299331 | 3082 | 29649992 |
Tongue oedema | 19.76 | 10.78 | 67 | 299337 | 2713 | 29650361 |
Ischaemic stroke | 19.68 | 10.78 | 249 | 299155 | 16026 | 29637048 |
Adenovirus infection | 19.66 | 10.78 | 9 | 299395 | 4259 | 29648815 |
Hypertensive heart disease | 19.61 | 10.78 | 61 | 299343 | 2359 | 29650715 |
Multiple-drug resistance | 19.55 | 10.78 | 3 | 299401 | 2938 | 29650136 |
Irritability | 19.21 | 10.78 | 143 | 299261 | 22907 | 29630167 |
Hypertensive nephropathy | 19.20 | 10.78 | 23 | 299381 | 423 | 29652651 |
Drug eruption | 19.06 | 10.78 | 263 | 299141 | 17263 | 29635811 |
Arthropathy | 19.04 | 10.78 | 125 | 299279 | 20602 | 29632472 |
Brain stem infarction | 18.98 | 10.78 | 41 | 299363 | 1265 | 29651809 |
Disease recurrence | 18.92 | 10.78 | 75 | 299329 | 14086 | 29638988 |
Gout | 18.89 | 10.78 | 260 | 299144 | 17055 | 29636019 |
Eyelid oedema | 18.89 | 10.78 | 100 | 299304 | 4945 | 29648129 |
Apparent death | 18.76 | 10.78 | 6 | 299398 | 3536 | 29649538 |
Accelerated hypertension | 18.75 | 10.78 | 17 | 299387 | 222 | 29652852 |
Pericardial haemorrhage | 18.73 | 10.78 | 68 | 299336 | 2850 | 29650224 |
Ventricular septal defect | 18.65 | 10.78 | 6 | 299398 | 3523 | 29649551 |
Melaena | 18.59 | 10.78 | 440 | 298964 | 31997 | 29621077 |
Guillain-Barre syndrome | 18.52 | 10.78 | 100 | 299304 | 4983 | 29648091 |
Left ventricular enlargement | 18.47 | 10.78 | 26 | 299378 | 564 | 29652510 |
Hydronephrosis | 18.34 | 10.78 | 153 | 299251 | 8830 | 29644244 |
Renal failure | 18.32 | 10.78 | 1512 | 297892 | 127454 | 29525620 |
Epiglottic oedema | 18.25 | 10.78 | 15 | 299389 | 170 | 29652904 |
Hyperammonaemia | 18.17 | 10.78 | 17 | 299387 | 5503 | 29647571 |
Hepatic neoplasm | 18.07 | 10.78 | 50 | 299354 | 1809 | 29651265 |
Lymphocele | 18.06 | 10.78 | 43 | 299361 | 1417 | 29651657 |
Ventricular tachycardia | 18.05 | 10.78 | 152 | 299252 | 23710 | 29629364 |
Respiratory arrest | 18.03 | 10.78 | 196 | 299208 | 29062 | 29624012 |
Hepatic failure | 17.94 | 10.78 | 236 | 299168 | 33807 | 29619267 |
Acute myeloid leukaemia | 17.88 | 10.78 | 106 | 299298 | 17900 | 29635174 |
Therapeutic product effect decreased | 17.83 | 10.78 | 195 | 299209 | 28881 | 29624193 |
Schizophrenia | 17.81 | 10.78 | 40 | 299364 | 9008 | 29644066 |
Condition aggravated | 17.81 | 10.78 | 1163 | 298241 | 136703 | 29516371 |
Somnolence | 17.79 | 10.78 | 788 | 298616 | 95975 | 29557099 |
Fibrillary glomerulonephritis | 17.69 | 10.78 | 9 | 299395 | 40 | 29653034 |
Hypersensitivity vasculitis | 17.68 | 10.78 | 79 | 299325 | 3644 | 29649430 |
Diastolic dysfunction | 17.63 | 10.78 | 87 | 299317 | 4184 | 29648890 |
Acute myocardial infarction | 17.54 | 10.78 | 671 | 298733 | 52268 | 29600806 |
Drug intolerance | 17.47 | 10.78 | 333 | 299071 | 44958 | 29608116 |
Pulmonary embolism | 17.46 | 10.78 | 622 | 298782 | 77513 | 29575561 |
Zoonotic bacterial infection | 17.43 | 10.78 | 10 | 299394 | 59 | 29653015 |
Akathisia | 17.38 | 10.78 | 20 | 299384 | 5884 | 29647190 |
Myelosuppression | 17.35 | 10.78 | 29 | 299375 | 7293 | 29645781 |
Carotid artery stenosis | 17.26 | 10.78 | 92 | 299312 | 4562 | 29648512 |
Acute graft versus host disease in skin | 17.25 | 10.78 | 12 | 299392 | 4504 | 29648570 |
Status epilepticus | 17.22 | 10.78 | 55 | 299349 | 11017 | 29642057 |
Dyspnoea exertional | 17.19 | 10.78 | 470 | 298934 | 34960 | 29618114 |
Anxiety | 17.12 | 10.78 | 729 | 298675 | 89142 | 29563932 |
Pseudomonas infection | 17.06 | 10.78 | 51 | 299353 | 10431 | 29642643 |
Paranoia | 17.00 | 10.78 | 49 | 299355 | 10139 | 29642935 |
Atheroembolism | 16.99 | 10.78 | 16 | 299388 | 220 | 29652854 |
Acute coronary syndrome | 16.99 | 10.78 | 209 | 299195 | 13364 | 29639710 |
Product substitution issue | 16.94 | 10.78 | 164 | 299240 | 9871 | 29643203 |
Clear cell renal cell carcinoma | 16.83 | 10.78 | 32 | 299372 | 899 | 29652175 |
Graft versus host disease in skin | 16.82 | 10.78 | 6 | 299398 | 3301 | 29649773 |
Left ventricular hypertrophy | 16.81 | 10.78 | 114 | 299290 | 6164 | 29646910 |
Metastatic renal cell carcinoma | 16.79 | 10.78 | 59 | 299345 | 2433 | 29650641 |
Retinopathy hypertensive | 16.57 | 10.78 | 17 | 299387 | 261 | 29652813 |
Polypectomy | 16.54 | 10.78 | 23 | 299381 | 493 | 29652581 |
Swelling face | 16.54 | 10.78 | 301 | 299103 | 20903 | 29632171 |
Hospitalisation | 16.44 | 10.78 | 328 | 299076 | 43991 | 29609083 |
Thrombotic stroke | 16.42 | 10.78 | 17 | 299387 | 264 | 29652810 |
Encephalopathy | 16.34 | 10.78 | 225 | 299179 | 31980 | 29621094 |
Neurotoxicity | 16.26 | 10.78 | 72 | 299332 | 13110 | 29639964 |
Coronary artery stenosis | 16.19 | 10.78 | 150 | 299254 | 8920 | 29644154 |
Vomiting | 16.18 | 10.78 | 1937 | 297467 | 217881 | 29435193 |
Blood pressure decreased | 16.15 | 10.78 | 599 | 298805 | 46476 | 29606598 |
Deep vein thrombosis | 16.05 | 10.78 | 471 | 298933 | 60030 | 29593044 |
Small for dates baby | 16.01 | 10.78 | 6 | 299398 | 3202 | 29649872 |
Haemorrhage subcutaneous | 15.97 | 10.78 | 54 | 299350 | 2183 | 29650891 |
Atrioventricular block second degree | 15.96 | 10.78 | 68 | 299336 | 3072 | 29650002 |
Lymphadenopathy | 15.96 | 10.78 | 161 | 299243 | 24215 | 29628859 |
Psoriasis | 15.95 | 10.78 | 314 | 299090 | 42192 | 29610882 |
Diabetic neuropathy | 15.89 | 10.78 | 80 | 299324 | 3879 | 29649195 |
Pharyngeal oedema | 15.86 | 10.78 | 115 | 299289 | 6356 | 29646718 |
Mydriasis | 15.82 | 10.78 | 23 | 299381 | 6120 | 29646954 |
Milk-alkali syndrome | 15.77 | 10.78 | 23 | 299381 | 516 | 29652558 |
Lacrimal disorder | 15.75 | 10.78 | 18 | 299386 | 314 | 29652760 |
Aortic aneurysm | 15.74 | 10.78 | 114 | 299290 | 6299 | 29646775 |
Nipple inflammation | 15.72 | 10.78 | 10 | 299394 | 73 | 29653001 |
Hallucination | 15.63 | 10.78 | 372 | 299032 | 48687 | 29604387 |
Angina unstable | 15.60 | 10.78 | 190 | 299214 | 12120 | 29640954 |
Blood creatine phosphokinase increased | 15.54 | 10.78 | 560 | 298844 | 43288 | 29609786 |
Presyncope | 15.50 | 10.78 | 236 | 299168 | 15820 | 29637254 |
Tremor | 15.49 | 10.78 | 606 | 298798 | 74757 | 29578317 |
Crying | 15.45 | 10.78 | 20 | 299384 | 5589 | 29647485 |
Cognitive disorder | 15.29 | 10.78 | 157 | 299247 | 23533 | 29629541 |
Lymphoma | 15.24 | 10.78 | 51 | 299353 | 10070 | 29643004 |
Drug screen positive | 15.19 | 10.78 | 13 | 299391 | 4394 | 29648680 |
Tricuspid valve calcification | 15.18 | 10.78 | 5 | 299399 | 4 | 29653070 |
Hair colour changes | 15.12 | 10.78 | 42 | 299362 | 1523 | 29651551 |
Embolic stroke | 15.11 | 10.78 | 74 | 299330 | 3548 | 29649526 |
Neuroleptic malignant syndrome | 15.10 | 10.78 | 98 | 299306 | 16197 | 29636877 |
Neuropathy peripheral | 15.07 | 10.78 | 564 | 298840 | 69911 | 29583163 |
Discomfort | 15.03 | 10.78 | 214 | 299190 | 14142 | 29638932 |
White blood cell count decreased | 14.95 | 10.78 | 686 | 298718 | 83261 | 29569813 |
Band neutrophil percentage decreased | 14.91 | 10.78 | 6 | 299398 | 13 | 29653061 |
Left atrial enlargement | 14.90 | 10.78 | 21 | 299383 | 456 | 29652618 |
Chest pain | 14.83 | 10.78 | 1367 | 298037 | 116260 | 29536814 |
Pruritus | 14.79 | 10.78 | 1373 | 298031 | 116831 | 29536243 |
Dermatitis infected | 14.74 | 10.78 | 11 | 299393 | 107 | 29652967 |
Skin toxicity | 14.74 | 10.78 | 7 | 299397 | 3242 | 29649832 |
Drug use disorder | 14.73 | 10.78 | 7 | 299397 | 3241 | 29649833 |
Osteoporosis | 14.55 | 10.78 | 56 | 299348 | 10607 | 29642467 |
Nasal crusting | 14.51 | 10.78 | 20 | 299384 | 425 | 29652649 |
Intervertebral disc displacement | 14.51 | 10.78 | 13 | 299391 | 167 | 29652907 |
Non-compaction cardiomyopathy | 14.46 | 10.78 | 4 | 299400 | 0 | 29653074 |
Ventricular compliance decreased | 14.46 | 10.78 | 4 | 299400 | 0 | 29653074 |
Blood aldosterone decreased | 14.46 | 10.78 | 4 | 299400 | 0 | 29653074 |
Hypoinsulinaemia | 14.46 | 10.78 | 4 | 299400 | 0 | 29653074 |
Vertebrobasilar stroke | 14.46 | 10.78 | 4 | 299400 | 0 | 29653074 |
Mucosal membrane hyperplasia | 14.46 | 10.78 | 4 | 299400 | 0 | 29653074 |
Kidney small | 14.46 | 10.78 | 9 | 299395 | 63 | 29653011 |
Polymyalgia rheumatica | 14.41 | 10.78 | 33 | 299371 | 1060 | 29652014 |
Coronary artery disease | 14.37 | 10.78 | 621 | 298783 | 49091 | 29603983 |
Malabsorption | 14.22 | 10.78 | 48 | 299356 | 1939 | 29651135 |
Blood pressure abnormal | 14.18 | 10.78 | 119 | 299285 | 6880 | 29646194 |
Hyperbilirubinaemia | 14.17 | 10.78 | 105 | 299299 | 16837 | 29636237 |
Large intestine polyp | 14.09 | 10.78 | 115 | 299289 | 6594 | 29646480 |
Hepatitis | 14.09 | 10.78 | 149 | 299255 | 22207 | 29630867 |
Clostridium difficile infection | 14.08 | 10.78 | 96 | 299308 | 15687 | 29637387 |
Toxic nodular goitre | 14.06 | 10.78 | 6 | 299398 | 16 | 29653058 |
Blood aldosterone increased | 14.06 | 10.78 | 6 | 299398 | 16 | 29653058 |
Hypertensive emergency | 14.03 | 10.78 | 28 | 299376 | 816 | 29652258 |
Body temperature decreased | 14.02 | 10.78 | 153 | 299251 | 9502 | 29643572 |
Device related infection | 13.97 | 10.78 | 106 | 299298 | 16909 | 29636165 |
Drug abuser | 13.96 | 10.78 | 14 | 299390 | 4387 | 29648687 |
Immune-mediated myositis | 13.95 | 10.78 | 36 | 299368 | 1249 | 29651825 |
Gastric cancer | 13.93 | 10.78 | 91 | 299313 | 4859 | 29648215 |
Tenosynovitis | 13.88 | 10.78 | 9 | 299395 | 3506 | 29649568 |
Maternal exposure during pregnancy | 13.86 | 10.78 | 11 | 299393 | 3860 | 29649214 |
Post-traumatic amnestic disorder | 13.84 | 10.78 | 8 | 299396 | 48 | 29653026 |
Sinonasal obstruction | 13.80 | 10.78 | 6 | 299398 | 17 | 29653057 |
Cardio-respiratory arrest | 13.77 | 10.78 | 452 | 298952 | 56854 | 29596220 |
Surfactant protein increased | 13.77 | 10.78 | 5 | 299399 | 7 | 29653067 |
Epstein-Barr virus infection | 13.74 | 10.78 | 29 | 299375 | 6677 | 29646397 |
High density lipoprotein decreased | 13.69 | 10.78 | 66 | 299338 | 3144 | 29649930 |
Cystic fibrosis | 13.66 | 10.78 | 3 | 299401 | 2271 | 29650803 |
Macroglossia | 13.64 | 10.78 | 14 | 299390 | 215 | 29652859 |
Crohn's disease | 13.63 | 10.78 | 14 | 299390 | 4338 | 29648736 |
Blood uric acid increased | 13.61 | 10.78 | 105 | 299299 | 5918 | 29647156 |
Generalised oedema | 13.60 | 10.78 | 180 | 299224 | 11705 | 29641369 |
Sinus node dysfunction | 13.60 | 10.78 | 75 | 299329 | 3768 | 29649306 |
Therapeutic product effect incomplete | 13.60 | 10.78 | 247 | 299157 | 33587 | 29619487 |
Nodal rhythm | 13.57 | 10.78 | 38 | 299366 | 1385 | 29651689 |
Seronegative arthritis | 13.55 | 10.78 | 27 | 299377 | 786 | 29652288 |
Myocardial infarction | 13.51 | 10.78 | 1444 | 297960 | 124181 | 29528893 |
Breath sounds abnormal | 13.45 | 10.78 | 90 | 299314 | 4845 | 29648229 |
Albumin urine present | 13.44 | 10.78 | 18 | 299386 | 372 | 29652702 |
Blood cholinesterase decreased | 13.43 | 10.78 | 11 | 299393 | 124 | 29652950 |
Ear infection | 13.40 | 10.78 | 34 | 299370 | 7340 | 29645734 |
Putamen haemorrhage | 13.39 | 10.78 | 14 | 299390 | 220 | 29652854 |
Sex hormone binding globulin increased | 13.38 | 10.78 | 5 | 299399 | 8 | 29653066 |
Hepatitis B reactivation | 13.36 | 10.78 | 6 | 299398 | 2871 | 29650203 |
Low density lipoprotein decreased | 13.35 | 10.78 | 30 | 299374 | 951 | 29652123 |
Wrong strength | 13.34 | 10.78 | 10 | 299394 | 98 | 29652976 |
Delusion | 13.31 | 10.78 | 68 | 299336 | 11921 | 29641153 |
Incorrect route of product administration | 13.24 | 10.78 | 63 | 299341 | 11252 | 29641822 |
Liver carcinoma ruptured | 13.22 | 10.78 | 11 | 299393 | 127 | 29652947 |
Haemodialysis | 13.21 | 10.78 | 169 | 299235 | 10904 | 29642170 |
Duodenal ulcer haemorrhage | 13.21 | 10.78 | 86 | 299318 | 4586 | 29648488 |
Arteriosclerosis | 13.21 | 10.78 | 166 | 299238 | 10667 | 29642407 |
Peripheral artery occlusion | 13.19 | 10.78 | 38 | 299366 | 1408 | 29651666 |
Thromboangiitis obliterans | 13.10 | 10.78 | 6 | 299398 | 20 | 29653054 |
Fungal infection | 13.01 | 10.78 | 81 | 299323 | 13519 | 29639555 |
Coronary arterial stent insertion | 12.98 | 10.78 | 79 | 299325 | 4115 | 29648959 |
Acute biphenotypic leukaemia | 12.97 | 10.78 | 8 | 299396 | 55 | 29653019 |
Macrophages increased | 12.92 | 10.78 | 12 | 299392 | 162 | 29652912 |
Platelet count decreased | 12.91 | 10.78 | 900 | 298504 | 105229 | 29547845 |
Rhythm idioventricular | 12.85 | 10.78 | 15 | 299389 | 268 | 29652806 |
Yellow skin | 12.78 | 10.78 | 48 | 299356 | 2045 | 29651029 |
Colitis ulcerative | 12.78 | 10.78 | 88 | 299316 | 14346 | 29638728 |
Malaise | 12.77 | 10.78 | 1879 | 297525 | 165083 | 29487991 |
Antipsychotic drug level increased | 12.65 | 10.78 | 8 | 299396 | 3158 | 29649916 |
Serotonin syndrome | 12.63 | 10.78 | 116 | 299288 | 17775 | 29635299 |
Fracture displacement | 12.62 | 10.78 | 8 | 299396 | 58 | 29653016 |
Hypertensive encephalopathy | 12.59 | 10.78 | 17 | 299387 | 354 | 29652720 |
Therapy partial responder | 12.58 | 10.78 | 11 | 299393 | 3680 | 29649394 |
Musculoskeletal stiffness | 12.58 | 10.78 | 268 | 299136 | 35613 | 29617461 |
Giant cell arteritis | 12.56 | 10.78 | 24 | 299380 | 677 | 29652397 |
Suspected suicide attempt | 12.55 | 10.78 | 11 | 299393 | 137 | 29652937 |
Dysphagia | 12.51 | 10.78 | 452 | 298952 | 56246 | 29596828 |
Renin increased | 12.51 | 10.78 | 8 | 299396 | 59 | 29653015 |
Gastrointestinal ischaemia | 12.50 | 10.78 | 13 | 299391 | 203 | 29652871 |
Neonatal respiratory distress syndrome | 12.46 | 10.78 | 13 | 299391 | 3999 | 29649075 |
Cataract | 12.45 | 10.78 | 296 | 299108 | 21539 | 29631535 |
Nausea | 12.45 | 10.78 | 2702 | 296702 | 294255 | 29358819 |
Cytomegalovirus viraemia | 12.40 | 10.78 | 24 | 299380 | 5705 | 29647369 |
Cachexia | 12.39 | 10.78 | 30 | 299374 | 6581 | 29646493 |
Lung diffusion test decreased | 12.38 | 10.78 | 22 | 299382 | 586 | 29652488 |
Ureteric cancer | 12.35 | 10.78 | 12 | 299392 | 172 | 29652902 |
Product dose omission issue | 12.33 | 10.78 | 770 | 298634 | 90861 | 29562213 |
Prescription drug used without a prescription | 12.33 | 10.78 | 34 | 299370 | 1228 | 29651846 |
Hypersensitivity | 12.32 | 10.78 | 429 | 298975 | 53599 | 29599475 |
Dysgeusia | 12.31 | 10.78 | 330 | 299074 | 24471 | 29628603 |
Kinematic imbalances due to suboccipital strain | 12.28 | 10.78 | 6 | 299398 | 24 | 29653050 |
Viral infection | 12.28 | 10.78 | 95 | 299309 | 15090 | 29637984 |
Obsessive-compulsive disorder | 12.22 | 10.78 | 14 | 299390 | 4127 | 29648947 |
Prostatic specific antigen increased | 12.19 | 10.78 | 178 | 299226 | 11826 | 29641248 |
Mycobacterium marinum infection | 12.17 | 10.78 | 14 | 299390 | 246 | 29652828 |
Body temperature increased | 12.17 | 10.78 | 92 | 299312 | 14688 | 29638386 |
Histology abnormal | 12.15 | 10.78 | 15 | 299389 | 285 | 29652789 |
Migraine | 12.15 | 10.78 | 77 | 299327 | 12797 | 29640277 |
Muscle rigidity | 12.09 | 10.78 | 57 | 299347 | 10204 | 29642870 |
Mycobacterium avium complex infection | 12.05 | 10.78 | 6 | 299398 | 2705 | 29650369 |
Enterococcal infection | 12.00 | 10.78 | 42 | 299362 | 8182 | 29644892 |
Overdose | 12.00 | 10.78 | 989 | 298415 | 83348 | 29569726 |
Intraventricular haemorrhage | 12.00 | 10.78 | 61 | 299343 | 2969 | 29650105 |
On and off phenomenon | 11.97 | 10.78 | 7 | 299397 | 2884 | 29650190 |
Herbal interaction | 11.97 | 10.78 | 16 | 299388 | 330 | 29652744 |
Arterial stenosis | 11.96 | 10.78 | 33 | 299371 | 1192 | 29651882 |
Thrombotic cerebral infarction | 11.95 | 10.78 | 15 | 299389 | 290 | 29652784 |
Thirst | 11.94 | 10.78 | 114 | 299290 | 6835 | 29646239 |
Graft versus host disease in gastrointestinal tract | 11.93 | 10.78 | 8 | 299396 | 3061 | 29650013 |
Cerebral haemorrhage | 11.90 | 10.78 | 421 | 298983 | 32466 | 29620608 |
Hepatitis B | 11.83 | 10.78 | 27 | 299377 | 6045 | 29647029 |
Hepatic enzyme increased | 11.80 | 10.78 | 250 | 299154 | 33244 | 29619830 |
Oliguria | 11.79 | 10.78 | 120 | 299284 | 7319 | 29645755 |
Dysphonia | 11.78 | 10.78 | 261 | 299143 | 18771 | 29634303 |
Acidosis | 11.78 | 10.78 | 156 | 299248 | 10145 | 29642929 |
Mitral valve thickening | 11.73 | 10.78 | 13 | 299391 | 219 | 29652855 |
Ventricular hyperkinesia | 11.73 | 10.78 | 13 | 299391 | 219 | 29652855 |
Lymphomatoid papulosis | 11.71 | 10.78 | 12 | 299392 | 184 | 29652890 |
Anuria | 11.70 | 10.78 | 156 | 299248 | 10160 | 29642914 |
Physical deconditioning | 11.67 | 10.78 | 22 | 299382 | 614 | 29652460 |
Hypocalcaemia | 11.65 | 10.78 | 288 | 299116 | 21088 | 29631986 |
Gastric ulcer haemorrhage | 11.65 | 10.78 | 92 | 299312 | 5222 | 29647852 |
Large intestinal polypectomy | 11.59 | 10.78 | 8 | 299396 | 68 | 29653006 |
Blood glucose increased | 11.57 | 10.78 | 738 | 298666 | 60792 | 29592282 |
Hyperparathyroidism secondary | 11.56 | 10.78 | 32 | 299372 | 1158 | 29651916 |
Hypothyroidism | 11.53 | 10.78 | 212 | 299192 | 14751 | 29638323 |
Stomatitis | 11.51 | 10.78 | 284 | 299120 | 36995 | 29616079 |
Ventricular hypertrophy | 11.49 | 10.78 | 86 | 299318 | 4801 | 29648273 |
Bacteraemia | 11.37 | 10.78 | 100 | 299304 | 15460 | 29637614 |
Atrial septal defect | 11.35 | 10.78 | 32 | 299372 | 6669 | 29646405 |
Respiratory failure | 11.34 | 10.78 | 859 | 298545 | 99783 | 29553291 |
Noninfective gingivitis | 11.34 | 10.78 | 14 | 299390 | 266 | 29652808 |
Prostate cancer recurrent | 11.31 | 10.78 | 24 | 299380 | 731 | 29652343 |
Carotid arteriosclerosis | 11.30 | 10.78 | 27 | 299377 | 892 | 29652182 |
Aortic valve stenosis | 11.25 | 10.78 | 40 | 299364 | 1659 | 29651415 |
Faeces discoloured | 11.24 | 10.78 | 199 | 299205 | 13747 | 29639327 |
Renal artery thrombosis | 11.20 | 10.78 | 15 | 299389 | 310 | 29652764 |
Haemodynamic instability | 11.17 | 10.78 | 126 | 299278 | 7889 | 29645185 |
Product solubility abnormal | 11.17 | 10.78 | 20 | 299384 | 536 | 29652538 |
Hyperdynamic left ventricle | 11.13 | 10.78 | 8 | 299396 | 73 | 29653001 |
Erectile dysfunction | 11.13 | 10.78 | 248 | 299156 | 17854 | 29635220 |
Intercapillary glomerulosclerosis | 11.13 | 10.78 | 7 | 299397 | 50 | 29653024 |
Inguinal hernia, obstructive | 11.09 | 10.78 | 6 | 299398 | 31 | 29653043 |
Toxic skin eruption | 11.06 | 10.78 | 163 | 299241 | 10852 | 29642222 |
Low birth weight baby | 11.06 | 10.78 | 28 | 299376 | 6048 | 29647026 |
Hepatic function abnormal | 11.03 | 10.78 | 519 | 298885 | 41426 | 29611648 |
Cerebellar haemorrhage | 11.02 | 10.78 | 35 | 299369 | 1369 | 29651705 |
Diabetes mellitus | 11.01 | 10.78 | 518 | 298886 | 41347 | 29611727 |
Cold sweat | 11.00 | 10.78 | 139 | 299265 | 8943 | 29644131 |
Clostridial infection | 10.98 | 10.78 | 12 | 299392 | 3613 | 29649461 |
Irregular breathing | 10.94 | 10.78 | 10 | 299394 | 132 | 29652942 |
Gingival hypoplasia | 10.86 | 10.78 | 4 | 299400 | 6 | 29653068 |
Fracture pain | 10.86 | 10.78 | 4 | 299400 | 6 | 29653068 |
Coma scale | 10.86 | 10.78 | 4 | 299400 | 6 | 29653068 |
Tissue injury | 10.85 | 10.78 | 3 | 299401 | 0 | 29653074 |
Wernicke's encephalopathy | 10.85 | 10.78 | 3 | 299401 | 0 | 29653074 |
Urostomy | 10.85 | 10.78 | 3 | 299401 | 0 | 29653074 |
Lower gastrointestinal perforation | 10.85 | 10.78 | 3 | 299401 | 0 | 29653074 |
Benign anorectal neoplasm | 10.85 | 10.78 | 3 | 299401 | 0 | 29653074 |
Epinephrine increased | 10.85 | 10.78 | 3 | 299401 | 0 | 29653074 |
Hypertrophy | 10.84 | 10.78 | 15 | 299389 | 320 | 29652754 |
Oedema due to cardiac disease | 10.84 | 10.78 | 5 | 299399 | 17 | 29653057 |
Angiogram | 10.81 | 10.78 | 9 | 299395 | 104 | 29652970 |
Bundle branch block | 10.80 | 10.78 | 26 | 299378 | 863 | 29652211 |
Pelvic cyst | 10.79 | 10.78 | 6 | 299398 | 33 | 29653041 |
Source | Code | Description |
---|---|---|
ATC | C08CA01 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
ATC | C07FB07 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FB12 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FB13 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C08CA51 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
ATC | C08GA02 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS CALCIUM CHANNEL BLOCKERS AND DIURETICS Calcium channel blockers and diuretics |
ATC | C09BB03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09BB04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09BB07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09BX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09BX03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09BX04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09DB01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB02 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB05 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB09 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09XA53 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors |
ATC | C09XA54 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors |
ATC | C10BX03 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX09 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX11 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX14 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX18 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA CS | M0006414 | Dihydropyridines |
FDA MoA | N0000000069 | Calcium Channel Antagonists |
FDA EPC | N0000175421 | Dihydropyridine Calcium Channel Blocker |
CHEBI has role | CHEBI:35620 | vasodilator |
CHEBI has role | CHEBI:35674 | antihypertensive |
CHEBI has role | CHEBI:38215 | calcium channel blockers |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002121 | Calcium Channel Blockers |
MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D014665 | Vasodilator Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Prinzmetal angina | indication | 87343002 | |
Angina pectoris | indication | 194828000 | |
Cerebrovascular accident | indication | 230690007 | |
Primary Prevention of Coronary Heart Disease | indication | ||
Myocardial Infarction Prevention | indication | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Alcoholism | contraindication | 7200002 | |
Hyperkalemia | contraindication | 14140009 | |
Jaundice | contraindication | 18165001 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Obstruction of bile duct | contraindication | 30144000 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
Low blood pressure | contraindication | 45007003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Hemorrhagic cerebral infarction | contraindication | 230706003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Rhabdomyolysis | contraindication | 240131006 | |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Surgical procedure | contraindication | 387713003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Traumatic injury | contraindication | 417746004 | |
Azotemia | contraindication | 445009001 | |
Head and Neck Angioedema | contraindication | ||
Hemodialysis with High-Flux Membrane | contraindication | ||
Severe Aortic Valve Stenosis | contraindication | ||
Intestinal Angioedema | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.0 | Basic |
pKa2 | 1.55 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 10MG BASE;200MG | CONSENSI | COEPTIS | N210045 | May 31, 2018 | RX | TABLET | ORAL | May 31, 2021 | NEW COMBINULLTION |
EQ 2.5MG BASE;200MG | CONSENSI | COEPTIS | N210045 | May 31, 2018 | RX | TABLET | ORAL | May 31, 2021 | NEW COMBINULLTION |
EQ 5MG BASE;200MG | CONSENSI | COEPTIS | N210045 | May 31, 2018 | RX | TABLET | ORAL | May 31, 2021 | NEW COMBINULLTION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Voltage-dependent L-type calcium channel subunit alpha-1D | Ion channel | BLOCKER | Ki | 7 | WOMBAT-PK | CHEMBL | |||
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | BLOCKER | WOMBAT-PK | CHEMBL | |||||
Voltage-dependent calcium channel gamma-1 subunit | Ion channel | Ki | 7.20 | WOMBAT-PK | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.65 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.87 | DRUG MATRIX | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.58 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.36 | DRUG MATRIX | |||||
Carbonic anhydrase 1 | Enzyme | WOMBAT-PK | |||||||
Aldehyde oxidase | Enzyme | IC50 | 5.26 | WOMBAT-PK | |||||
Voltage-dependent T-type calcium channel subunit alpha-1H | Ion channel | Ki | 4.51 | WOMBAT-PK | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 5.27 | CHEMBL | |||||
Potassium channel subfamily K member 2 | Ion channel | IC50 | 6.40 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 5.63 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 5.10 | CHEMBL | |||||
Voltage-dependent calcium channel subunit alpha-2/delta-1 | Ion channel | Ki | 7.20 | WOMBAT-PK | |||||
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | Ki | 8.70 | CHEMBL |
ID | Source |
---|---|
1J444QC288 | UNII |
4020813 | VUID |
N0000148333 | NUI |
D00615 | KEGG_DRUG |
111470-99-6 | SECONDARY_CAS_RN |
C0051696 | UMLSCUI |
CHEBI:2669 | CHEBI |
6UB | PDB_CHEM_ID |
06X | PDB_CHEM_ID |
CHEMBL1491 | ChEMBL_ID |
CHEMBL1200402 | ChEMBL_ID |
CHEMBL1200984 | ChEMBL_ID |
DB00381 | DRUGBANK_ID |
D017311 | MESH_DESCRIPTOR_UI |
2162 | PUBCHEM_CID |
5729 | INN_ID |
6981 | IUPHAR_LIGAND_ID |
104416 | RXNORM |
108736 | MMSL |
173594 | MMSL |
23944 | MMSL |
27341 | MMSL |
4180 | MMSL |
d00689 | MMSL |
003672 | NDDF |
003673 | NDDF |
008599 | NDDF |
015579 | NDDF |
108537001 | SNOMEDCT_US |
384976003 | SNOMEDCT_US |
386864001 | SNOMEDCT_US |
421048000 | SNOMEDCT_US |
4020586 | VANDF |
4020813 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1520 | TABLET | 2.50 mg | ORAL | NDA | 26 sections |
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1530 | TABLET | 5 mg | ORAL | NDA | 26 sections |
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1540 | TABLET | 10 mg | ORAL | NDA | 26 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2150 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2160 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2170 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2180 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2190 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2250 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2260 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2270 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2960 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2970 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2980 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 32 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0364 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0379 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0405 | CAPSULE | 5 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0406 | CAPSULE | 5 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0488 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0489 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0490 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0491 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0559 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0560 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0561 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0562 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0563 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0093-5002 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 26 sections |
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0093-5003 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 26 sections |
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0093-5004 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |