amlodipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 183 88150-42-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amlodipine
  • amlopres
  • racemic amlodipine
  • amlodipine besylate
  • amlodipine besilate
  • amlodipine maleate
  • amlodipine mesylate
  • amlodipine mesilate
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
  • Molecular weight: 408.88
  • Formula: C20H25ClN2O5
  • CLOGP: 3.43
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.88
  • ALOGS: -4.74
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.35 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 34 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.860 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 19.011 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 6.871 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 7.447 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 5.810 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 12.550 % High 1
herg hERG pIC50 5.331 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 3.243 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 7.079 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 7.050 % High 1
kinase-safety-class ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,IGF1R,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 43
kinase-selectivity-class AXL,BRAF,GRK2,PDK4,PIK3CD 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 15.066 High 1
mh-clint Mouse hepatocyte intrinsic clearance 27.164 High 1
mppb Mouse plasma protein binding (% unbound) 5.070 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 51.404 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 11.180 % High 1
rh-clint Rat hepatocyte intrinsic clearance 37.325 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 21.090 % High 1
rppb Rat plasma protein binding (% unbound) 7.220 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 48.529 uM High 1

Approvals:

DateAgencyCompanyOrphan
July 31, 1992 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1879.83 9.34 3209 534523 141849 89948866
Pemphigus 1724.64 9.34 46 537686 326818 89763897
Hand deformity 1455.81 9.34 73 537659 296289 89794426
Hypotension 1437.30 9.34 4720 533012 320677 89770038
Glossodynia 1408.98 9.34 139 537593 321640 89769075
Systemic lupus erythematosus 1391.34 9.34 237 537495 361659 89729056
Anti-cyclic citrullinated peptide antibody positive 1299.62 9.34 20 537712 236413 89854302
Pericarditis 1261.65 9.34 88 537644 270063 89820652
Maternal exposure during pregnancy 1227.24 9.34 312 537420 359751 89730964
Synovitis 1156.44 9.34 269 537463 329483 89761232
Duodenal ulcer perforation 1145.44 9.34 37 537695 221251 89869464
Acute kidney injury 1120.33 9.34 4305 533427 316082 89774633
Folliculitis 1115.86 9.34 19 537713 204334 89886381
Wound 1076.69 9.34 240 537492 302740 89787975
Helicobacter infection 1073.52 9.34 69 537663 226781 89863934
Infusion related reaction 1006.74 9.34 614 537118 416166 89674549
Contraindicated product administered 978.56 9.34 339 537393 319800 89770915
Arthropathy 904.83 9.34 525 537207 365717 89724998
Muscle injury 895.13 9.34 35 537697 176619 89914096
Treatment failure 844.45 9.34 373 537359 303555 89787160
Rheumatic fever 836.85 9.34 14 537718 153107 89937608
Drug intolerance 824.53 9.34 864 536868 446727 89643988
Intentional overdose 813.42 9.34 1751 535981 92083 89998632
Impaired healing 809.06 9.34 197 537535 234002 89856713
Irritable bowel syndrome 805.28 9.34 132 537600 207316 89883399
Drug ineffective 804.88 9.34 4877 532855 1379421 88711294
Shock 799.03 9.34 919 536813 27859 90062856
Toxicity to various agents 781.47 9.34 3581 534151 284265 89806450
Hyponatraemia 772.34 9.34 2132 535600 131406 89959309
Hepatic enzyme increased 745.69 9.34 627 537105 360109 89730606
Blood pressure increased 729.00 9.34 2699 535033 194518 89896197
Fall 715.61 9.34 5100 532632 476710 89614005
Discomfort 696.37 9.34 380 537352 273955 89816760
Sleep disorder due to general medical condition, insomnia type 694.13 9.34 14 537718 128680 89962035
Alopecia 691.49 9.34 1172 536560 493899 89596816
Therapeutic product effect decreased 690.85 9.34 394 537338 277177 89813538
Distributive shock 672.40 9.34 352 537380 3072 90087643
Non-cardiogenic pulmonary oedema 670.44 9.34 258 537474 966 90089749
Fibromyalgia 657.14 9.34 203 537529 206066 89884649
Psoriatic arthropathy 639.17 9.34 277 537455 228058 89862657
Rheumatoid factor positive 625.73 9.34 128 537604 171522 89919193
C-reactive protein abnormal 620.23 9.34 33 537699 127396 89963319
Hypersensitivity 615.13 9.34 1098 536634 453579 89637136
Vasoplegia syndrome 612.40 9.34 310 537422 2504 90088211
Bradycardia 612.36 9.34 1462 536270 82385 90008330
Swollen joint count increased 604.18 9.34 11 537721 111195 89979520
Type 2 diabetes mellitus 589.12 9.34 234 537498 203010 89887705
Ill-defined disorder 588.87 9.34 182 537550 184709 89906006
Gingival hypertrophy 588.46 9.34 279 537453 1921 90088794
Cerebrovascular accident 584.00 9.34 1836 535896 121697 89969018
Swelling 564.05 9.34 1015 536717 418043 89672672
Lower respiratory tract infection 556.52 9.34 405 537327 250254 89840461
Exposure during pregnancy 553.43 9.34 367 537365 238043 89852672
Lactic acidosis 543.70 9.34 1031 536701 49432 90041283
Facet joint syndrome 541.77 9.34 8 537724 98381 89992334
Blood pressure inadequately controlled 512.79 9.34 367 537365 5857 90084858
Abdominal discomfort 511.21 9.34 1314 536418 476014 89614701
Orthostatic hypotension 501.57 9.34 895 536837 40932 90049783
Injury 501.18 9.34 273 537459 197076 89893639
Joint range of motion decreased 496.74 9.34 100 537632 135543 89955172
Off label use 481.62 9.34 4208 533524 1098044 88992671
Liver injury 466.13 9.34 214 537518 170353 89920362
Metabolic acidosis 464.14 9.34 1023 536709 54653 90036062
Lip dry 462.08 9.34 36 537696 100919 89989796
Breast cancer stage III 460.18 9.34 8 537724 84439 90006276
Renal impairment 448.78 9.34 1512 536220 103909 89986806
Stomatitis 442.39 9.34 589 537143 274109 89816606
Bursitis 440.53 9.34 118 537614 131536 89959179
Blister 433.22 9.34 525 537207 254473 89836242
Oedema peripheral 397.69 9.34 2757 534975 255158 89835557
Wound infection 396.84 9.34 75 537657 106327 89984388
Infection 393.42 9.34 989 536743 361105 89729610
Grip strength decreased 391.94 9.34 45 537687 92531 89998184
Deep vein thrombosis postoperative 388.80 9.34 6 537726 70803 90019912
Hyperkalaemia 376.12 9.34 1038 536694 63926 90026789
Blood cholesterol increased 375.22 9.34 408 537324 207604 89883111
Live birth 368.33 9.34 26 537706 79081 90011634
Drug interaction 363.91 9.34 2846 534886 273607 89817108
Peripheral venous disease 359.80 9.34 39 537693 83882 90006833
Prescribed overdose 333.28 9.34 84 537648 97541 89993174
Product use issue 331.16 9.34 937 536795 328982 89761733
Musculoskeletal stiffness 321.17 9.34 811 536921 295721 89794994
Intentional product use issue 314.79 9.34 500 537232 216392 89874323
Rheumatoid arthritis 313.93 9.34 1101 536631 361513 89729202
Adjustment disorder with depressed mood 306.67 9.34 6 537726 56747 90033968
Autoimmune disorder 304.06 9.34 46 537686 76698 90014017
Dislocation of vertebra 302.10 9.34 6 537726 55962 90034753
Hypokalaemia 301.84 9.34 1557 536175 129559 89961156
Angioedema 300.72 9.34 958 536774 63918 90026797
Blood creatinine increased 299.94 9.34 1295 536437 100091 89990624
Balance disorder 298.01 9.34 1254 536478 95826 89994889
Hypoglycaemia 290.32 9.34 994 536738 68854 90021861
Creatinine renal clearance decreased 283.38 9.34 447 537285 18452 90072263
Cardiac failure congestive 277.80 9.34 1242 536490 97452 89993263
Depressed level of consciousness 276.04 9.34 1005 536727 71779 90018936
Obesity 270.61 9.34 144 537588 105363 89985352
Sinusitis 269.41 9.34 1084 536648 342004 89748711
Pregnancy 268.12 9.34 28 537704 62019 90028696
Atrial fibrillation 264.65 9.34 1523 536209 132088 89958627
Dehydration 263.03 9.34 2015 535717 192432 89898283
Gastrointestinal disorder 262.70 9.34 722 537010 255965 89834750
Renal failure 255.36 9.34 1487 536245 129520 89961195
X-ray abnormal 248.74 9.34 4 537728 45420 90045295
Syncope 248.41 9.34 1490 536242 131173 89959542
Myocardial infarction 246.36 9.34 1262 536470 104710 89986005
Night sweats 245.21 9.34 241 537491 128525 89962190
Overdose 242.35 9.34 1685 536047 156024 89934691
Therapeutic product effect incomplete 240.94 9.34 492 537240 193404 89897311
Lupus vulgaris 234.92 9.34 7 537725 45052 90045663
Palpitations 234.27 9.34 1501 536231 135227 89955488
Hypercholesterolaemia 225.07 9.34 162 537570 100730 89989985
Blepharospasm 222.49 9.34 32 537700 55413 90035302
Joint swelling 221.94 9.34 1914 535818 501386 89589329
Sedation complication 221.90 9.34 377 537355 16567 90074148
Urticaria 221.69 9.34 1027 536705 311707 89779008
Condition aggravated 218.62 9.34 2369 535363 593176 89497539
Suspected suicide 217.28 9.34 276 537456 9292 90081423
Pulmonary oedema 214.47 9.34 832 536900 61248 90029467
Gait inability 213.02 9.34 337 537395 146119 89944596
Hip arthroplasty 212.21 9.34 93 537639 76115 90014600
Cough 211.07 9.34 3216 534516 365746 89724969
Dizziness 210.78 9.34 4774 532958 584510 89506205
Dyspnoea 210.12 9.34 6769 530963 874186 89216529
Road traffic accident 204.26 9.34 202 537530 107424 89983291
Lower limb fracture 203.77 9.34 126 537606 84887 90005828
Migraine 200.42 9.34 528 537204 189864 89900851
Sleep disorder 198.12 9.34 563 537169 197467 89893248
Sciatica 197.38 9.34 186 537546 101196 89989519
Blood calcium decreased 196.69 9.34 504 537228 29678 90061037
Injection site reaction 196.21 9.34 155 537577 91925 89998790
Schizoaffective disorder 193.40 9.34 193 537539 4954 90085761
Blood pressure decreased 191.16 9.34 916 536816 73979 90016736
Osteoarthritis 188.15 9.34 567 537165 195163 89895552
Drug level increased 186.54 9.34 469 537263 27293 90063422
Lung disorder 186.45 9.34 380 537352 149503 89941212
Onychomadesis 185.85 9.34 26 537706 45972 90044743
Retinitis 183.87 9.34 11 537721 38447 90052268
Hypertensive crisis 183.71 9.34 357 537375 17427 90073288
Weight increased 183.40 9.34 1591 536141 416336 89674379
Cognitive disorder 183.06 9.34 857 536875 68550 90022165
Angina pectoris 183.04 9.34 580 537152 38580 90052135
Circulatory collapse 178.22 9.34 431 537301 24473 90066242
Rhabdomyolysis 177.92 9.34 688 537044 50568 90040147
Hemiplegia 177.52 9.34 333 537399 15827 90074888
Suicide attempt 177.37 9.34 901 536831 74498 90016217
Hyperglycaemia 176.79 9.34 684 537048 50286 90040429
Cardiogenic shock 176.76 9.34 425 537307 24043 90066672
Nail disorder 176.03 9.34 65 537667 59002 90031713
Inflammation 175.52 9.34 512 537220 178080 89912635
Neurologic neglect syndrome 172.78 9.34 237 537495 8610 90082105
Breast cancer stage II 172.35 9.34 9 537723 35325 90055390
Rash 172.06 9.34 3512 534220 792588 89298127
Cerebral infarction 171.12 9.34 442 537290 26154 90064561
C-reactive protein 170.76 9.34 3 537729 31364 90059351
Arthralgia 166.88 9.34 3439 534293 775083 89315632
Cardiac failure 164.70 9.34 1164 536568 108332 89982383
Dysarthria 164.23 9.34 700 537032 53782 90036933
Chronic kidney disease 162.36 9.34 659 537073 49532 90041183
Carotid artery thrombosis 160.41 9.34 232 537500 8860 90081855
Anuria 154.94 9.34 299 537433 14519 90076196
Coeliac disease 154.93 9.34 37 537695 44573 90046142
Coronary artery disease 150.79 9.34 491 537241 33132 90057583
Nasal oedema 149.63 9.34 190 537542 6394 90084321
Blood pressure systolic increased 146.30 9.34 710 537022 57635 90033080
Constipation 146.22 9.34 2407 535325 277988 89812727
Product use in unapproved indication 145.66 9.34 1284 536448 334952 89755763
Bone erosion 145.58 9.34 66 537666 52955 90037760
Hypoaesthesia 145.05 9.34 1180 536552 313030 89777685
Anaemia 143.84 9.34 2914 534818 349888 89740827
Foot deformity 143.52 9.34 88 537644 59563 90031152
BRASH syndrome 141.63 9.34 105 537627 1774 90088941
Atrioventricular block complete 141.52 9.34 228 537504 9583 90081132
Nasopharyngitis 141.43 9.34 1639 536093 405465 89685250
Knee arthroplasty 141.39 9.34 171 537561 83011 90007704
Pain 140.18 9.34 4678 533054 991663 89099052
Mobility decreased 139.24 9.34 893 536839 249841 89840874
Adjustment disorder 138.98 9.34 224 537508 9418 90081297
Finger deformity 136.73 9.34 17 537715 32880 90057835
Device expulsion 136.05 9.34 37 537695 40849 90049866
Proteinuria 135.60 9.34 373 537359 22918 90067797
Blood urea increased 133.59 9.34 441 537291 29972 90060743
Anti-cyclic citrullinated peptide antibody 132.56 9.34 7 537725 27214 90063501
Personality disorder 132.45 9.34 253 537479 12191 90078524
Back injury 131.22 9.34 56 537676 46566 90044149
Acute myocardial infarction 129.92 9.34 479 537253 34411 90056304
Product prescribing error 128.75 9.34 433 537299 29712 90061003
Dysphagia 126.68 9.34 1117 536615 111161 89979554
Sinus bradycardia 126.28 9.34 298 537434 16654 90074061
Blood glucose increased 124.23 9.34 979 536753 94267 89996448
Transient ischaemic attack 122.68 9.34 545 537187 42631 90048084
Pulmonary fibrosis 122.56 9.34 286 537446 107217 89983498
Respiratory failure 122.39 9.34 1156 536576 117262 89973453
Sprue-like enteropathy 121.96 9.34 74 537658 879 90089836
Aphasia 120.59 9.34 539 537193 42273 90048442
Exostosis 120.22 9.34 84 537648 53050 90037665
Swollen tongue 120.11 9.34 566 537166 45390 90045325
Hypomagnesaemia 119.69 9.34 473 537259 35115 90055600
Abortion spontaneous 118.98 9.34 88 537644 53968 90036747
Red blood cell sedimentation rate abnormal 118.58 9.34 6 537726 24198 90066517
Eating disorder 117.92 9.34 401 537331 27672 90063043
Sedation 113.53 9.34 576 537156 47595 90043120
Gangrene 112.29 9.34 241 537491 12635 90078080
Affect lability 110.90 9.34 295 537437 17768 90072947
Adverse event 110.75 9.34 343 537389 117075 89973640
C-reactive protein increased 110.67 9.34 627 537105 180762 89909953
Diabetes mellitus inadequate control 110.55 9.34 301 537431 18383 90072332
Hemiparesis 110.33 9.34 427 537305 31392 90059323
Hypoxia 110.23 9.34 772 536960 71627 90019088
Asthenia 109.36 9.34 4032 533700 529719 89560996
Musculoskeletal pain 108.28 9.34 585 537147 170666 89920049
Pyrexia 107.86 9.34 3039 534693 657446 89433269
Subacute cutaneous lupus erythematosus 107.25 9.34 119 537613 3463 90087252
Myelosuppression 107.05 9.34 96 537636 53495 90037220
Atrioventricular block first degree 107.02 9.34 186 537546 8325 90082390
Loss of consciousness 107.02 9.34 1288 536444 138950 89951765
Lupus-like syndrome 106.88 9.34 80 537652 48766 90041949
Hepatic function abnormal 105.96 9.34 549 537183 45739 90044976
Myalgia 105.22 9.34 1540 536192 173585 89917130
Renin increased 104.06 9.34 41 537691 166 90090549
Onychomycosis 103.44 9.34 46 537686 37330 90053385
Motor dysfunction 102.22 9.34 298 537434 18932 90071783
Hypertensive emergency 102.05 9.34 93 537639 2124 90088591
General physical health deterioration 101.79 9.34 1488 536244 353627 89737088
Gastrointestinal haemorrhage 100.85 9.34 896 536836 89352 90001363
Hepatic cirrhosis 100.29 9.34 137 537595 63116 90027599
Contusion 100.26 9.34 979 536753 250237 89840478
Maternal exposure timing unspecified 100.15 9.34 9 537723 22474 90068241
Melaena 99.44 9.34 440 537292 34357 90056358
Sensory loss 97.91 9.34 282 537450 17793 90072922
Blood potassium decreased 97.69 9.34 549 537183 47178 90043537
Disability 96.79 9.34 61 537671 40684 90050031
Oliguria 96.30 9.34 202 537530 10422 90080293
Lip swelling 96.18 9.34 469 537263 38141 90052574
Prescribed underdose 96.01 9.34 187 537545 74832 90015883
Renal disorder 95.11 9.34 461 537271 37398 90053317
Liver function test increased 94.93 9.34 228 537504 84627 90006088
Dry mouth 94.91 9.34 670 537062 183389 89907326
Glomerular filtration rate decreased 94.47 9.34 267 537465 16665 90074050
Malaise 93.33 9.34 4310 533422 581676 89509039
Lethargy 93.05 9.34 668 537064 62471 90028244
Coordination abnormal 92.30 9.34 308 537424 21048 90069667
Feeling abnormal 92.11 9.34 1449 536283 165786 89924929
Laryngitis 92.04 9.34 99 537633 50654 90040061
Cardiac arrest 91.88 9.34 990 536742 103945 89986770
Colitis ulcerative 91.13 9.34 135 537597 60131 90030584
Walking aid user 90.23 9.34 49 537683 35457 90055258
Therapy non-responder 89.76 9.34 461 537271 136243 89954472
Diarrhoea 89.69 9.34 6596 531136 932594 89158121
Sinus congestion 89.42 9.34 361 537371 27063 90063652
Anti-neutrophil cytoplasmic antibody positive vasculitis 88.80 9.34 114 537618 3879 90086836
Pneumonia 88.48 9.34 4630 533102 633429 89457286
Pemphigoid 88.16 9.34 177 537555 8849 90081866
Inappropriate antidiuretic hormone secretion 87.61 9.34 285 537447 19220 90071495
Swelling face 87.48 9.34 801 536931 80551 90010164
Atrioventricular block 86.27 9.34 173 537559 8642 90082073
Altered state of consciousness 85.82 9.34 393 537339 31139 90059576
Ear infection 85.81 9.34 178 537554 69597 90021118
Immunodeficiency 85.69 9.34 78 537654 43156 90047559
Arterial occlusive disease 85.44 9.34 212 537520 12234 90078481
Left ventricular hypertrophy 84.85 9.34 140 537592 6004 90084711
Vertigo 84.22 9.34 705 537027 69106 90021609
Vomiting 83.30 9.34 5583 532149 782710 89308005
Joint stiffness 83.16 9.34 215 537517 77827 90012888
Blood creatine phosphokinase increased 83.12 9.34 411 537321 33612 90057103
Haemoglobin decreased 81.65 9.34 1383 536349 160573 89930142
Linear IgA disease 81.28 9.34 83 537649 2191 90088524
Epilepsy 80.48 9.34 236 537496 81970 90008745
Dyspepsia 78.72 9.34 773 536959 197387 89893328
Skin exfoliation 77.81 9.34 678 537054 67235 90023480
Infusion site reaction 76.35 9.34 11 537721 19028 90071687
Liver disorder 76.24 9.34 415 537317 120854 89969861
Vision blurred 75.60 9.34 993 536739 109300 89981415
Renal artery stenosis 75.18 9.34 78 537654 2099 90088616
Haematemesis 74.44 9.34 396 537336 33330 90057385
Mental status changes 74.32 9.34 487 537245 44192 90046523
Nocturia 73.93 9.34 178 537554 10077 90080638
Arrhythmia 73.85 9.34 467 537265 41865 90048850
Skin haemorrhage 73.38 9.34 286 537446 21094 90069621
Carotid artery stenosis 72.93 9.34 121 537611 5213 90085502
Normal newborn 72.54 9.34 24 537708 23338 90067377
Electrocardiogram abnormal 72.37 9.34 177 537555 10121 90080594
Dyspnoea exertional 71.37 9.34 699 537033 71589 90019126
Ischaemic stroke 70.85 9.34 290 537442 21876 90068839
Foetal death 70.38 9.34 18 537714 20705 90070010
Harlequin syndrome 69.92 9.34 32 537700 201 90090514
Blood potassium increased 69.15 9.34 275 537457 20474 90070241
Pollakiuria 67.77 9.34 380 537352 32625 90058090
Seronegative arthritis 67.65 9.34 13 537719 18221 90072494
Heart rate decreased 67.58 9.34 546 537186 52959 90037756
Subcutaneous drug absorption impaired 67.51 9.34 3 537729 13542 90077173
Electrocardiogram QT prolonged 67.37 9.34 692 537040 71764 90018951
Cerebral haemorrhage 66.01 9.34 390 537342 34132 90056583
Hypervolaemia 65.85 9.34 375 537357 32382 90058333
Ear pain 65.37 9.34 154 537578 57548 90033167
Gingival swelling 64.93 9.34 111 537621 4902 90085813
Hyperlipidaemia 64.90 9.34 289 537443 22627 90068088
Plasma cell myeloma 64.88 9.34 440 537292 40388 90050327
Ulcer haemorrhage 64.48 9.34 38 537694 26283 90064432
Tubulointerstitial nephritis 63.95 9.34 309 537423 25034 90065681
Somnolence 63.91 9.34 1659 536073 207425 89883290
Vasodilatation 63.61 9.34 82 537650 2802 90087913
Vasculitis 63.37 9.34 285 537447 22408 90068307
Death 63.19 9.34 3313 534419 453238 89637477
Joint dislocation 62.53 9.34 105 537627 44477 90046238
Lacunar infarction 62.26 9.34 88 537644 3289 90087426
Temperature regulation disorder 61.91 9.34 7 537725 14572 90076143
Cataract 61.18 9.34 676 537056 71416 90019299
Urine output decreased 61.04 9.34 189 537543 12414 90078301
Decreased appetite 60.80 9.34 2774 534958 373766 89716949
Product quality issue 60.66 9.34 253 537479 79072 90011643
Macular degeneration 60.43 9.34 82 537650 37888 90052827
Taste disorder 60.02 9.34 177 537555 61369 90029346
Pleural effusion 60.00 9.34 966 536766 111025 89979690
Hypocalcaemia 59.98 9.34 444 537288 41924 90048791
Lung diffusion test abnormal 59.91 9.34 32 537700 292 90090423
Urinary tract infection 59.86 9.34 2298 535434 303334 89787381
Hypophagia 59.34 9.34 391 537341 35546 90055169
Disorientation 58.92 9.34 456 537276 43658 90047057
Bundle branch block right 58.20 9.34 111 537621 5342 90085373
Dementia 58.11 9.34 288 537444 23573 90067142
Drug resistance 57.93 9.34 57 537675 30392 90060323
Haemodynamic instability 57.74 9.34 177 537555 11562 90079153
Myocardial ischaemia 57.73 9.34 197 537535 13617 90077098
General symptom 57.62 9.34 9 537723 14659 90076056
Sneezing 57.47 9.34 338 537394 29531 90061184
Hypothermia 57.29 9.34 213 537519 15362 90075353
Injection site erythema 57.12 9.34 346 537386 98156 89992559
Aortic dissection 56.91 9.34 71 537661 2346 90088369
Foetal exposure during pregnancy 56.85 9.34 105 537627 42870 90047845
Protein urine present 56.68 9.34 127 537605 6857 90083858
Arteriosclerosis 56.55 9.34 167 537565 10686 90080029
Upper respiratory tract infection 56.37 9.34 488 537244 127830 89962885
Female genital tract fistula 56.11 9.34 18 537714 17850 90072865
Supraventricular extrasystoles 56.09 9.34 107 537625 5150 90085565
Generalised oedema 56.02 9.34 243 537489 18810 90071905
Product monitoring error 55.44 9.34 98 537634 4446 90086269
Subdural haematoma 54.98 9.34 220 537512 16425 90074290
Dysgeusia 54.73 9.34 514 537218 52046 90038669
Electrolyte imbalance 54.60 9.34 282 537450 23463 90067252
Vitamin B1 decreased 54.42 9.34 36 537696 502 90090213
Urinary retention 54.27 9.34 397 537335 37347 90053368
Multiple drug therapy 54.16 9.34 125 537607 6884 90083831
Pulmonary renal syndrome 54.03 9.34 37 537695 548 90090167
Product substitution issue 53.97 9.34 231 537501 17777 90072938
Respiratory tract infection 53.39 9.34 561 537171 58517 90032198
Chest discomfort 53.37 9.34 1134 536598 137231 89953484
Haemorrhage subcutaneous 53.24 9.34 82 537650 3314 90087401
Acute respiratory distress syndrome 52.88 9.34 321 537411 28365 90062350
Joint destruction 52.54 9.34 8 537724 13279 90077436
Diabetes mellitus 52.19 9.34 602 537130 64273 90026442
Physical deconditioning 51.59 9.34 65 537667 2170 90088545
Drug tolerance decreased 51.53 9.34 69 537663 32061 90058654
Blood lactic acid decreased 50.67 9.34 32 537700 410 90090305
Osteoporosis 50.42 9.34 350 537382 96181 89994534
Nephrotic syndrome 50.37 9.34 125 537607 7214 90083501
Memory impairment 50.21 9.34 845 536887 196399 89894316
Adverse drug reaction 49.42 9.34 448 537284 116253 89974462
Chest pain 49.03 9.34 2343 535389 317302 89773413
Abdominal pain upper 48.86 9.34 1552 536180 331122 89759593
Mitral valve incompetence 48.71 9.34 263 537469 22261 90068454
Nodal rhythm 48.68 9.34 57 537675 1761 90088954
Atrioventricular block second degree 47.98 9.34 91 537641 4361 90086354
Red blood cell sedimentation rate increased 47.95 9.34 290 537442 82305 90008410
Platelet count decreased 47.90 9.34 1107 536625 135862 89954853
Drug-induced liver injury 47.40 9.34 327 537405 89991 90000724
Gamma-glutamyltransferase increased 47.23 9.34 386 537346 37566 90053149
Sinus disorder 47.07 9.34 358 537374 34089 90056626
Gingival bleeding 46.86 9.34 194 537538 14709 90076006
Faeces discoloured 46.82 9.34 250 537482 21070 90069645
Heart rate increased 46.72 9.34 935 536797 111967 89978748
Sinus rhythm 46.68 9.34 49 537683 1337 90089378
Compartment syndrome 46.62 9.34 71 537661 2841 90087874
Blood pressure abnormal 46.35 9.34 235 537497 19410 90071305
Angina unstable 46.24 9.34 119 537613 7024 90083691
Hyperdynamic left ventricle 45.99 9.34 26 537706 268 90090447
Glomerulonephritis rapidly progressive 45.96 9.34 47 537685 1243 90089472
Ageusia 45.72 9.34 203 537529 15873 90074842
Incorrect route of product administration 45.55 9.34 151 537581 50475 90040240
Tongue oedema 45.19 9.34 100 537632 5354 90085361
Cardiac output increased 45.01 9.34 32 537700 505 90090210
Adverse reaction 44.48 9.34 67 537665 29645 90061070
Nausea 44.02 9.34 7359 530373 1102957 88987758
Hyperlactacidaemia 43.91 9.34 84 537648 4052 90086663
Tremor 43.81 9.34 1205 536527 151968 89938747
Maternal exposure before pregnancy 43.77 9.34 7 537725 11206 90079509
Pustular psoriasis 43.77 9.34 28 537704 18528 90072187
Cerebral ischaemia 43.64 9.34 117 537615 7079 90083636
Skin discolouration 43.49 9.34 428 537304 43887 90046828
Neovascularisation 43.47 9.34 51 537681 1579 90089136
Proctitis 43.47 9.34 18 537714 15241 90075474
Hyperaldosteronism 43.20 9.34 26 537706 304 90090411
Interstitial lung disease 42.79 9.34 664 537068 75741 90014974
Hyperuricaemia 42.54 9.34 111 537621 6608 90084107
Epistaxis 42.18 9.34 725 537007 84400 90006315
Intentional self-injury 42.15 9.34 68 537664 29266 90061449
Blood lactic acid increased 41.92 9.34 131 537601 8647 90082068
Oedema 41.83 9.34 1517 536215 198778 89891937
Blood glucose decreased 41.82 9.34 260 537472 23169 90067546
Drug abuse 41.82 9.34 301 537431 82046 90008669
Blood sodium decreased 41.76 9.34 294 537438 27319 90063396
Upper gastrointestinal haemorrhage 41.65 9.34 256 537476 22720 90067995
Fibromuscular dysplasia 41.49 9.34 25 537707 293 90090422
Pulmonary hypertension 41.39 9.34 410 537322 42113 90048602
Haemodialysis 41.28 9.34 130 537602 8617 90082098
Cystitis 40.94 9.34 589 537143 66129 90024586
Cardiomegaly 40.94 9.34 221 537511 18704 90072011
Acute respiratory failure 40.90 9.34 412 537320 42506 90048209
Dry skin 40.75 9.34 742 536990 87331 90003384
Nephrosclerosis 40.58 9.34 42 537690 1127 90089588
Breast cancer stage I 39.93 9.34 5 537727 9619 90081096
Paraesthesia 39.90 9.34 1155 536577 249171 89841544
Hallucination, visual 39.81 9.34 254 537478 22838 90067877
Cardiac failure high output 39.70 9.34 28 537704 436 90090279
Tachypnoea 39.63 9.34 239 537493 21070 90069645
Glycosylated haemoglobin increased 39.45 9.34 190 537542 15372 90075343
Haemorrhage intracranial 39.07 9.34 186 537546 14976 90075739
Food allergy 38.58 9.34 57 537675 25421 90065294
Cardiac failure chronic 38.57 9.34 96 537636 5550 90085165
Frequent bowel movements 38.50 9.34 190 537542 56745 90033970
Rash vesicular 38.29 9.34 31 537701 18166 90072549
Presyncope 38.25 9.34 321 537411 31484 90059231
Renal cell carcinoma 38.19 9.34 76 537656 3775 90086940
Drug ineffective for unapproved indication 38.16 9.34 235 537497 66409 90024306
Gingival pain 38.04 9.34 135 537597 9517 90081198
Jaundice 37.95 9.34 326 537406 32191 90058524
Underdose 37.84 9.34 178 537554 53839 90036876
Respiratory disorder 37.40 9.34 228 537504 64588 90026127
Parkinsonism 37.31 9.34 174 537558 13891 90076824
Radiculopathy 37.13 9.34 33 537699 18472 90072243
Nephrogenic systemic fibrosis 37.11 9.34 78 537654 4030 90086685
Thirst 37.10 9.34 193 537539 16102 90074613
Head injury 37.10 9.34 314 537418 30874 90059841
Gastric ulcer haemorrhage 37.02 9.34 91 537641 5220 90085495
Listless 37.00 9.34 68 537664 3181 90087534
Periodontitis 36.97 9.34 75 537657 3778 90086937
Head discomfort 36.88 9.34 193 537539 16140 90074575
Blood aldosterone increased 36.85 9.34 20 537712 189 90090526
Blood alkaline phosphatase increased 36.83 9.34 442 537290 47637 90043078
Hypercalcaemia 36.73 9.34 337 537395 33903 90056812
Conjoined twins 36.37 9.34 28 537704 502 90090213
Peripheral coldness 36.22 9.34 171 537561 13721 90076994
Diabetic nephropathy 36.22 9.34 48 537684 1686 90089029
Cardiac disorder 36.07 9.34 505 537227 56367 90034348
Intestinal malrotation 36.06 9.34 26 537706 420 90090295
Gingivitis 36.04 9.34 130 537602 9239 90081476
Loss of personal independence in daily activities 35.97 9.34 579 537153 135526 89955189
Renal function test abnormal 35.91 9.34 109 537623 7082 90083633
Acute coronary syndrome 35.78 9.34 143 537589 10670 90080045
Tenosynovitis 35.72 9.34 21 537711 14546 90076169
Haematoma 35.38 9.34 371 537361 38677 90052038
Chronic sinusitis 35.32 9.34 54 537678 23748 90066967
Multiple organ dysfunction syndrome 35.31 9.34 586 537146 67750 90022965
Femoral neck fracture 35.21 9.34 137 537595 10096 90080619
Ischaemia 35.09 9.34 89 537643 5206 90085509
International normalised ratio increased 34.95 9.34 432 537300 46884 90043831
Loose tooth 34.90 9.34 72 537660 3671 90087044
Infective pulmonary exacerbation of cystic fibrosis 34.77 9.34 9 537723 10270 90080445
Blood pressure fluctuation 34.70 9.34 469 537263 51944 90038771
Exercise tolerance decreased 34.51 9.34 111 537621 7440 90083275
Cellulitis 34.38 9.34 746 536986 90591 90000124
Palmar-plantar erythrodysaesthesia syndrome 34.33 9.34 284 537448 27739 90062976
Myocardial depression 34.03 9.34 29 537703 604 90090111
Nephrogenic anaemia 33.79 9.34 56 537676 2410 90088305
Purpura 33.63 9.34 175 537557 14603 90076112
Schizophrenia 33.18 9.34 24 537708 14890 90075825
Peripheral arterial occlusive disease 33.09 9.34 80 537652 4541 90086174
Pancreatitis acute 32.90 9.34 313 537419 31802 90058913
Drug eruption 32.83 9.34 338 537394 35069 90055646
Injection site pain 32.80 9.34 782 536950 172917 89917798
Hepatotoxicity 32.74 9.34 150 537582 45692 90045023
Body temperature increased 32.71 9.34 145 537587 44565 90046150
Pericardial effusion 32.46 9.34 348 537384 36485 90054230
Drug tolerance 32.42 9.34 35 537697 17881 90072834
Ventricular extrasystoles 32.32 9.34 160 537572 13090 90077625
Colitis ischaemic 32.21 9.34 152 537580 12194 90078521
Urinary incontinence 32.21 9.34 353 537379 37213 90053502
Retinopathy hypertensive 32.04 9.34 21 537711 288 90090427
Vaginal discharge 32.03 9.34 41 537691 19423 90071292
Vulvovaginal pruritus 31.72 9.34 72 537660 3921 90086794
Conduction disorder 31.67 9.34 45 537687 1690 90089025
Prerenal failure 31.67 9.34 50 537682 2065 90088650
Aortic aneurysm 31.60 9.34 76 537656 4299 90086416
Dialysis 31.42 9.34 142 537590 11187 90079528
Pulse abnormal 30.82 9.34 61 537671 3018 90087697
Aplastic anaemia 30.79 9.34 158 537574 13111 90077604
Caesarean section 30.71 9.34 39 537693 18538 90072177
Labile hypertension 30.60 9.34 25 537707 490 90090225
Cryopyrin associated periodic syndrome 30.49 9.34 26 537706 542 90090173
Premature labour 30.45 9.34 21 537711 13355 90077360
Hepatocellular carcinoma 30.45 9.34 53 537679 2375 90088340
Gravitational oedema 30.39 9.34 37 537695 1192 90089523
Bladder irritation 30.38 9.34 21 537711 316 90090399
Gastrooesophageal reflux disease 30.27 9.34 753 536979 165584 89925131
Injection site swelling 30.25 9.34 219 537513 59620 90031095
Chromaturia 30.02 9.34 206 537526 18981 90071734
Therapy partial responder 29.92 9.34 53 537679 21990 90068725
Eye swelling 29.91 9.34 286 537446 29100 90061615
Product dispensing error 29.79 9.34 148 537584 12125 90078590
Sinus arrest 29.77 9.34 49 537683 2097 90088618
Full blood count decreased 29.75 9.34 288 537444 29401 90061314
Flatulence 29.41 9.34 375 537357 40992 90049723
Hypoperfusion 29.28 9.34 44 537688 1740 90088975
Intestinal ischaemia 29.01 9.34 117 537615 8766 90081949
Product label on wrong product 28.93 9.34 7 537725 0 90090715
Oxygen saturation decreased 28.90 9.34 839 536893 106644 89984071
Urine albumin/creatinine ratio increased 28.85 9.34 25 537707 533 90090182
Leukocytosis 28.81 9.34 296 537436 30694 90060021
Labelled drug-drug interaction medication error 28.69 9.34 166 537566 14416 90076299
Cardio-respiratory arrest 28.53 9.34 530 537202 62610 90028105
Febrile neutropenia 28.50 9.34 718 537014 157631 89933084
Swollen joint count 28.47 9.34 8 537724 8645 90082070
Hypoglycaemic coma 28.45 9.34 58 537674 2932 90087783
Glucose tolerance impaired 28.37 9.34 108 537624 7877 90082838
Haematotoxicity 28.11 9.34 20 537712 12515 90078200
Clostridium test positive 28.04 9.34 83 537649 5318 90085397
Hip fracture 27.98 9.34 310 537422 32767 90057948
Abortion induced 27.96 9.34 18 537714 11870 90078845
Sinus node dysfunction 27.93 9.34 83 537649 5329 90085386
Cutaneous vasculitis 27.83 9.34 100 537632 7093 90083622
Device difficult to use 27.73 9.34 38 537694 17487 90073228
Injection site warmth 27.70 9.34 38 537694 17477 90073238
Procedural pain 27.66 9.34 103 537629 33257 90057458
Hypocholesterolaemia 27.63 9.34 3 537729 6446 90084269
Hallucination 27.53 9.34 547 537185 65412 90025303
Hypovolaemia 27.45 9.34 146 537586 12285 90078430
Lymphocyte stimulation test positive 27.44 9.34 23 537709 468 90090247
Nervousness 27.38 9.34 316 537416 33740 90056975
Skin tightness 27.25 9.34 73 537659 4415 90086300
Unintended pregnancy 27.18 9.34 6 537726 7631 90083084
Stomatitis haemorrhagic 27.12 9.34 13 537719 92 90090623
Body tinea 27.08 9.34 47 537685 2101 90088614
Premature delivery 26.99 9.34 128 537604 38634 90052081
Carotid arteriosclerosis 26.95 9.34 35 537697 1205 90089510
Device dislocation 26.90 9.34 96 537636 31386 90059329
Adenoma benign 26.85 9.34 31 537701 943 90089772
Hypoacusis 26.85 9.34 268 537464 27582 90063133
Cardiac myxoma 26.72 9.34 19 537713 300 90090415
Apathy 26.70 9.34 133 537599 10907 90079808
Dysuria 26.67 9.34 354 537378 39047 90051668
Productive cough 26.67 9.34 622 537110 76441 90014274
Humerus fracture 26.66 9.34 122 537610 9663 90081052
Haematochezia 26.63 9.34 579 537153 70334 90020381
Scleral discolouration 26.60 9.34 22 537710 439 90090276
Claustrophobia 26.60 9.34 36 537696 1291 90089424
Rib deformity 26.55 9.34 18 537714 262 90090453
Respiratory tract congestion 26.54 9.34 264 537468 27146 90063569
Mouth breathing 26.50 9.34 15 537717 155 90090560
Unresponsive to stimuli 26.43 9.34 344 537388 37777 90052938
Choking 26.35 9.34 141 537591 11892 90078823
Essential hypertension 26.34 9.34 90 537642 6225 90084490
Injection site pruritus 26.27 9.34 199 537533 53635 90037080
Inhibitory drug interaction 26.21 9.34 58 537674 3105 90087610
Gastritis 26.17 9.34 370 537362 41383 90049332
Pneumonia aspiration 26.15 9.34 364 537368 40576 90050139
Subarachnoid haemorrhage 26.13 9.34 189 537543 17715 90073000
Hypertensive heart disease 26.06 9.34 52 537680 2588 90088127
Hypertensive encephalopathy 25.98 9.34 27 537705 728 90089987
Poor quality sleep 25.96 9.34 242 537490 24451 90066264
Multiple-drug resistance 25.94 9.34 7 537725 7769 90082946
Chronic obstructive pulmonary disease 25.89 9.34 597 537135 73232 90017483
Pyelonephritis acute 25.88 9.34 81 537651 5351 90085364
Skin candida 25.85 9.34 41 537691 1700 90089015
Blood loss anaemia 25.85 9.34 124 537608 10016 90080699
Product administration error 25.83 9.34 255 537477 26168 90064547
End stage renal disease 25.72 9.34 110 537622 8461 90082254
Extrasystoles 25.71 9.34 83 537649 5574 90085141
Blood lactate dehydrogenase increased 25.71 9.34 251 537481 25681 90065034
Vitamin B1 increased 25.70 9.34 15 537717 165 90090550
Gastroenteritis 25.68 9.34 276 537456 28953 90061762
Therapeutic response decreased 25.65 9.34 376 537356 89353 90001362
Pancreatitis haemorrhagic 25.62 9.34 25 537707 624 90090091
Colitis microscopic 25.29 9.34 132 537600 11027 90079688
Forced vital capacity decreased 25.21 9.34 33 537699 1145 90089570
Gingival atrophy 25.13 9.34 9 537723 26 90090689
Tinnitus 25.06 9.34 377 537355 42725 90047990
Allergic reaction to excipient 25.02 9.34 27 537705 761 90089954
Bradyarrhythmia 24.93 9.34 49 537683 2412 90088303
Cardiac failure acute 24.92 9.34 138 537594 11791 90078924
Reduced facial expression 24.86 9.34 50 537682 2503 90088212
Wrong patient 24.85 9.34 28 537704 829 90089886
Uterine perforation 24.83 9.34 7 537725 7547 90083168
Hypernatraemia 24.81 9.34 116 537616 9271 90081444
Dermatitis bullous 24.76 9.34 124 537608 10192 90080523
Intestinal villi atrophy 24.66 9.34 19 537713 341 90090374
Kidney transplant rejection 24.61 9.34 74 537658 4783 90085932
Product tampering 24.46 9.34 21 537711 442 90090273
Atrioventricular dissociation 24.44 9.34 16 537716 219 90090496
Lymphocele 24.38 9.34 27 537705 784 90089931
Blood pressure diastolic decreased 24.36 9.34 255 537477 26571 90064144
Hyperkaliuria 24.32 9.34 11 537721 67 90090648
Cardiovascular disorder 24.25 9.34 150 537582 13342 90077373
Cytomegalovirus infection reactivation 24.24 9.34 8 537724 7792 90082923
Restlessness 24.21 9.34 321 537411 35399 90055316
Heart rate irregular 24.11 9.34 235 537497 24033 90066682
Pathogen resistance 24.06 9.34 9 537723 8106 90082609
Pseudolymphoma 24.05 9.34 24 537708 616 90090099
Renal transplant 24.03 9.34 39 537693 1649 90089066
Cerebrovascular disorder 23.87 9.34 52 537680 2754 90087961
Urosepsis 23.81 9.34 211 537521 21021 90069694
Retroperitoneal haematoma 23.79 9.34 58 537674 3310 90087405
Cardiac hypertrophy 23.67 9.34 32 537700 1146 90089569
Gastric ulcer 23.57 9.34 258 537474 27190 90063525
Cardiorenal syndrome 23.56 9.34 31 537701 1081 90089634
Gingival disorder 23.31 9.34 64 537668 3927 90086788
Dizziness postural 23.29 9.34 111 537621 8942 90081773
Shock haemorrhagic 23.19 9.34 138 537594 12107 90078608
Gallbladder adenocarcinoma 23.19 9.34 12 537720 102 90090613
Dermatitis exfoliative 23.18 9.34 79 537653 5457 90085258
Impaired insulin secretion 23.12 9.34 9 537723 35 90090680
Putamen haemorrhage 23.12 9.34 15 537717 202 90090513
Hypomania 23.01 9.34 12 537720 8885 90081830
Lupus nephritis 22.97 9.34 72 537660 4760 90085955
Iliac artery occlusion 22.91 9.34 16 537716 245 90090470
Overlap syndrome 22.91 9.34 11 537721 8537 90082178
Nightmare 22.89 9.34 213 537519 21512 90069203
Acute pulmonary oedema 22.88 9.34 115 537617 9465 90081250
Skin induration 22.85 9.34 56 537676 3206 90087509
Unintentional medical device removal 22.22 9.34 7 537725 7023 90083692
Congenital bladder anomaly 22.15 9.34 15 537717 218 90090497
Rectourethral fistula 22.12 9.34 8 537724 24 90090691
Congenital ureterocele 22.12 9.34 8 537724 24 90090691
Cholestasis 22.09 9.34 320 537412 35979 90054736
Kidney fibrosis 22.05 9.34 44 537688 2190 90088525
Diverticulum 21.98 9.34 135 537597 11978 90078737
Aortic stenosis 21.94 9.34 85 537647 6251 90084464
Increased appetite 21.90 9.34 132 537600 11633 90079082
Malpositioned teeth 21.88 9.34 8 537724 25 90090690
Prescription drug used without a prescription 21.87 9.34 55 537677 3200 90087515
Acute motor-sensory axonal neuropathy 21.86 9.34 18 537714 357 90090358
Dermatitis exfoliative generalised 21.85 9.34 78 537654 5515 90085200
Skin wrinkling 21.82 9.34 34 537698 1388 90089327
Post transplant lymphoproliferative disorder 21.82 9.34 7 537725 6942 90083773
Pseudoporphyria 21.80 9.34 16 537716 266 90090449
Influenza 21.78 9.34 1023 536709 138241 89952474
Diabetic retinopathy 21.78 9.34 49 537683 2653 90088062
Ischaemic cardiomyopathy 21.75 9.34 48 537684 2565 90088150
Eye injury 21.70 9.34 20 537712 11000 90079715
Urachal abnormality 21.69 9.34 15 537717 226 90090489
Benign neoplasm of adrenal gland 21.67 9.34 9 537723 43 90090672
Immunosuppressant drug level increased 21.58 9.34 69 537663 4611 90086104
Aspartate aminotransferase increased 21.57 9.34 780 536952 102157 89988558
Polyuria 21.55 9.34 117 537615 9923 90080792
Oral discharge 21.53 9.34 13 537719 153 90090562
Drug dependence 21.52 9.34 95 537637 29232 90061483
Ventricular failure 21.40 9.34 18 537714 368 90090347
Withdrawal hypertension 21.31 9.34 13 537719 156 90090559
Gout 21.26 9.34 172 537560 16687 90074028
Spondylitis 21.20 9.34 32 537700 14146 90076569
Spontaneous hyphaema 21.19 9.34 6 537726 5 90090710
Asthma 21.16 9.34 1690 536042 240470 89850245
Breath sounds abnormal 21.08 9.34 160 537572 15226 90075489
Hypoglossal nerve paralysis 21.01 9.34 7 537725 15 90090700
Persistent cloaca 20.98 9.34 15 537717 239 90090476
Myoglobin blood increased 20.94 9.34 35 537697 1517 90089198
Microangiopathy 20.94 9.34 37 537695 1678 90089037
Deafness 20.91 9.34 215 537517 22299 90068416
Vulvovaginal burning sensation 20.85 9.34 47 537685 2548 90088167
Stillbirth 20.85 9.34 9 537723 7434 90083281
Thalamus haemorrhage 20.82 9.34 24 537708 729 90089986
Abnormal loss of weight 20.81 9.34 88 537644 6735 90083980
Pigmentation disorder 20.76 9.34 80 537652 5869 90084846
Haemorrhagic diathesis 20.70 9.34 76 537656 5448 90085267
Lecithin-cholesterol acyltransferase deficiency 20.68 9.34 6 537726 6 90090709
Peritonitis 20.66 9.34 193 537539 19512 90071203
Mean arterial pressure decreased 20.64 9.34 14 537718 204 90090511
Retinal ischaemia 20.60 9.34 19 537713 441 90090274
Delirium 20.48 9.34 467 537265 103892 89986823
Diastolic dysfunction 20.40 9.34 92 537640 7241 90083474
Azotaemia 20.39 9.34 74 537658 5274 90085441
Organ failure 20.38 9.34 52 537680 3053 90087662
Amnesia 20.34 9.34 489 537243 108016 89982699
Ballismus 20.33 9.34 12 537720 135 90090580
Leukopenia 20.24 9.34 449 537283 100261 89990454
Diverticulum intestinal haemorrhagic 20.23 9.34 37 537695 1724 90088991
Gastrointestinal toxicity 20.08 9.34 16 537716 9451 90081264
Polyarthritis 19.97 9.34 50 537682 18300 90072415
Pernicious anaemia 19.92 9.34 25 537707 831 90089884
Hyperprolactinaemia 19.89 9.34 4 537728 5429 90085286
Colon cancer 19.88 9.34 122 537610 10822 90079893
Fluid intake reduced 19.86 9.34 62 537670 4090 90086625
Enthesopathy 19.81 9.34 16 537716 9388 90081327
Pulseless electrical activity 19.79 9.34 105 537627 8827 90081888
Wrong product administered 19.73 9.34 94 537638 7571 90083144
Injection site urticaria 19.66 9.34 49 537683 17962 90072753
Lichen nitidus 19.66 9.34 11 537721 111 90090604
Deformity 19.65 9.34 26 537706 12144 90078571
Sinus tachycardia 19.64 9.34 257 537475 28256 90062459
Duodenal ulcer 19.62 9.34 110 537622 9442 90081273
Blood sodium increased 19.56 9.34 52 537680 3130 90087585
Ocular icterus 19.56 9.34 60 537672 3920 90086795
Multiple sclerosis relapse 19.53 9.34 207 537525 52098 90038617
Brain stem infarction 19.51 9.34 25 537707 849 90089866
Blood uric acid increased 19.48 9.34 94 537638 7610 90083105
Vitello-intestinal duct remnant 19.47 9.34 8 537724 37 90090678
Hospice care 19.44 9.34 111 537621 9593 90081122
Coronary artery bypass 19.38 9.34 43 537689 2306 90088409
Hypermagnesaemia 19.36 9.34 30 537702 1219 90089496
Fryns syndrome 19.22 9.34 9 537723 60 90090655
Renal tubular necrosis 19.18 9.34 150 537582 14405 90076310
Visual acuity reduced 19.17 9.34 218 537514 23192 90067523
Congenital acrochordon 19.13 9.34 8 537724 39 90090676
Sudden hearing loss 19.08 9.34 32 537700 1391 90089324
Adulterated product 19.07 9.34 17 537715 377 90090338
Pancreatic toxicity 18.98 9.34 9 537723 62 90090653
Nail discolouration 18.95 9.34 52 537680 3190 90087525
Blood chloride decreased 18.89 9.34 81 537651 6238 90084477
Erythema multiforme 18.88 9.34 131 537601 12115 90078600
Nail ridging 18.78 9.34 19 537713 496 90090219
Dermatitis artefacta 18.74 9.34 9 537723 64 90090651
Bacteriuria 18.74 9.34 29 537703 1177 90089538
Malignant hypertension 18.72 9.34 29 537703 1178 90089537
Metastatic renal cell carcinoma 18.69 9.34 24 537708 817 90089898
Sinus arrhythmia 18.66 9.34 32 537700 1417 90089298
Concomitant disease progression 18.58 9.34 41 537691 2191 90088524
Product solubility abnormal 18.57 9.34 26 537706 963 90089752
Renal neoplasm 18.56 9.34 33 537699 1504 90089211
Creatinine renal clearance increased 18.56 9.34 52 537680 3229 90087486
Peritonitis bacterial 18.42 9.34 70 537662 5101 90085614
Insulin-like growth factor decreased 18.41 9.34 17 537715 395 90090320
Dyslalia 18.38 9.34 22 537710 696 90090019
Saliva discolouration 18.35 9.34 8 537724 44 90090671
Disseminated intravascular coagulation 18.29 9.34 202 537530 21336 90069379
Hypocalvaria 18.21 9.34 8 537724 45 90090670
Drug withdrawal syndrome 18.20 9.34 98 537634 28625 90062090
Cerebral atrophy 18.15 9.34 74 537658 5572 90085143
Hypertransaminasaemia 18.11 9.34 42 537690 15783 90074932
Transcription medication error 18.09 9.34 14 537718 253 90090462
Coronary arterial stent insertion 18.06 9.34 47 537685 2793 90087922
Galactorrhoea 18.05 9.34 3 537729 4669 90086046
Hyperthyroidism 18.04 9.34 177 537555 18133 90072582
Pulmonary alveolar haemorrhage 18.02 9.34 77 537655 5921 90084794
Speech disorder 18.02 9.34 375 537357 45210 90045505
Blood parathyroid hormone increased 18.01 9.34 53 537679 3384 90087331
Neoplasm skin 17.97 9.34 50 537682 3092 90087623
Neurosensory hypoacusis 17.82 9.34 13 537719 214 90090501
Infected dermal cyst 17.82 9.34 18 537714 469 90090246
Blood aldosterone decreased 17.75 9.34 5 537727 4 90090711
Autoimmune enteropathy 17.66 9.34 6 537726 14 90090701
Microscopic polyangiitis 17.62 9.34 13 537719 218 90090497
Blood pressure systolic abnormal 17.61 9.34 185 537547 19293 90071422
Pulmonary arterial hypertension 17.61 9.34 235 537497 25952 90064763
Rales 17.60 9.34 157 537575 15670 90075045
Morbid thoughts 17.52 9.34 22 537710 732 90089983
Ovarian cyst 17.47 9.34 49 537683 17269 90073446
Breast cancer female 17.45 9.34 39 537693 14847 90075868
Premature baby 17.35 9.34 83 537649 24994 90065721
Medical device site thrombosis 17.34 9.34 9 537723 77 90090638
Thrombotic thrombocytopenic purpura 17.28 9.34 59 537673 4079 90086636
Heavy menstrual bleeding 17.28 9.34 63 537669 20467 90070248
Face oedema 17.26 9.34 213 537519 23105 90067610
Blood pressure systolic decreased 17.25 9.34 104 537628 9166 90081549
Renal injury 17.25 9.34 112 537620 10131 90080584
Haemorrhage subepidermal 17.23 9.34 5 537727 5 90090710
Dermatitis atopic 17.20 9.34 214 537518 23258 90067457
Rectal ulcer haemorrhage 17.17 9.34 13 537719 227 90090488
Complication of device insertion 17.16 9.34 22 537710 10414 90080301
Blood lactic acid 17.14 9.34 10 537722 110 90090605
Asthma-chronic obstructive pulmonary disease overlap syndrome 17.14 9.34 4 537728 4895 90085820
Dysphonia 17.11 9.34 493 537239 62591 90028124
Anaphylactic reaction 17.08 9.34 392 537340 87132 90003583
Oxalosis 17.00 9.34 8 537724 54 90090661
Peptic ulcer 17.00 9.34 71 537661 5404 90085311
Orthopnoea 17 9.34 83 537649 6752 90083963
Metabolic alkalosis 16.98 9.34 53 537679 3496 90087219
Hypertensive angiopathy 16.96 9.34 9 537723 81 90090634
Blood creatine increased 16.90 9.34 84 537648 6883 90083832
Dilatation ventricular 16.87 9.34 41 537691 2335 90088380
Nasal polyps 16.81 9.34 24 537708 10856 90079859
Sinoatrial block 16.80 9.34 25 537707 980 90089735
Lip oedema 16.69 9.34 63 537669 4576 90086139
Therapeutic drug monitoring analysis not performed 16.65 9.34 29 537703 1300 90089415
Apical granuloma 16.64 9.34 8 537724 57 90090658
Oropharyngeal swelling 16.64 9.34 24 537708 914 90089801
Drug use disorder 16.59 9.34 15 537717 8328 90082387
Blood cholinesterase decreased 16.53 9.34 12 537720 196 90090519
Erysipelas 16.50 9.34 101 537631 8951 90081764
Fracture 16.49 9.34 202 537530 21874 90068841
Femoral artery dissection 16.44 9.34 7 537725 36 90090679
Electrocardiogram ST segment depression 16.43 9.34 50 537682 3253 90087462
Skin ulcer 16.36 9.34 401 537331 49674 90041041
Albuminuria 16.34 9.34 15 537717 346 90090369
Itching scar 16.33 9.34 5 537727 7 90090708
Blood lactic acid abnormal 16.28 9.34 7 537725 37 90090678
Spinal fusion surgery 16.25 9.34 30 537702 12253 90078462
Haemoptysis 16.22 9.34 283 537449 33037 90057678
Pallor 16.21 9.34 289 537443 33876 90056839
Metastases to fallopian tube 16.19 9.34 8 537724 61 90090654
Norepinephrine increased 16.19 9.34 8 537724 61 90090654
Nephropathy 16.18 9.34 102 537630 9133 90081582
Metastases to bone 16.18 9.34 87 537645 25418 90065297
Fear of injection 16.13 9.34 16 537716 8499 90082216
Hypothyroidism 16.05 9.34 421 537311 52706 90038009
Aortic occlusion 16.05 9.34 10 537722 125 90090590
Hyperparathyroidism secondary 16.04 9.34 34 537698 1767 90088948
Large intestine polyp 16.03 9.34 103 537629 9283 90081432
Ventricular septal defect 16.02 9.34 6 537726 5401 90085314
Electrocardiogram U wave present 15.98 9.34 9 537723 92 90090623
Stevens-Johnson syndrome 15.95 9.34 254 537478 29122 90061593
Coronary artery occlusion 15.94 9.34 96 537636 8458 90082257
Pelvic fracture 15.92 9.34 149 537583 15070 90075645
Cardiac valve disease 15.90 9.34 62 537670 4573 90086142
Stent placement 15.89 9.34 58 537674 4145 90086570
Burning sensation 15.89 9.34 491 537241 62961 90027754
Hallucination, gustatory 15.76 9.34 8 537724 65 90090650
Orbital swelling 15.76 9.34 8 537724 65 90090650
Congenital hydronephrosis 15.74 9.34 16 537716 420 90090295
Congenital nail disorder 15.74 9.34 9 537723 95 90090620
Brain natriuretic peptide increased 15.72 9.34 74 537658 5931 90084784
Scleroedema 15.71 9.34 10 537722 130 90090585
Systemic infection 15.68 9.34 63 537669 4712 90086003
IgA nephropathy 15.67 9.34 23 537709 890 90089825
Cerebellar haemorrhage 15.65 9.34 32 537700 1621 90089094
Hypergastrinaemia 15.65 9.34 10 537722 131 90090584
Microalbuminuria 15.61 9.34 18 537714 547 90090168
Eye allergy 15.58 9.34 28 537704 1287 90089428
Product complaint 15.57 9.34 135 537597 13365 90077350
Chronic pigmented purpura 15.56 9.34 11 537721 172 90090543
Scleroderma 15.55 9.34 76 537656 6185 90084530
Ascites 15.51 9.34 382 537350 47358 90043357
Glomerulonephritis acute 15.50 9.34 9 537723 98 90090617
Anti-erythropoietin antibody positive 15.48 9.34 15 537717 371 90090344
Injection site bruising 15.36 9.34 218 537514 52089 90038626
Femur fracture 15.35 9.34 370 537362 45712 90045003
Haemorrhoids 15.31 9.34 233 537499 26469 90064246
Dysstasia 15.30 9.34 221 537511 24831 90065884
Genitourinary tract neoplasm 15.29 9.34 7 537725 44 90090671
Cell marker increased 15.29 9.34 13 537719 270 90090445
Urine protein/creatinine ratio increased 15.26 9.34 24 537708 988 90089727
Sudden death 15.26 9.34 114 537618 10795 90079920
Pseudoaldosteronism 15.20 9.34 10 537722 138 90090577
Lung infiltration 15.19 9.34 148 537584 15134 90075581
Food interaction 15.09 9.34 27 537705 1237 90089478
Carotid artery occlusion 15.06 9.34 76 537656 6266 90084449
Renal haematoma 15.00 9.34 12 537720 228 90090487
Myopathy 14.98 9.34 134 537598 13384 90077331
Normochromic normocytic anaemia 14.94 9.34 65 537667 5037 90085678
Platelet aggregation decreased 14.91 9.34 6 537726 26 90090689
Fulminant type 1 diabetes mellitus 14.90 9.34 22 537710 856 90089859
Wrong patient received product 14.89 9.34 50 537682 3427 90087288
Product size issue 14.88 9.34 16 537716 449 90090266
Acute hepatic failure 14.84 9.34 76 537656 22485 90068230
Tongue discomfort 14.84 9.34 43 537689 2722 90087993
Biopsy kidney 14.83 9.34 11 537721 186 90090529
Oesophageal motility disorder 14.79 9.34 19 537713 647 90090068
Gestational diabetes 14.77 9.34 25 537707 10557 90080158
Gastrointestinal stromal tumour 14.72 9.34 28 537704 1345 90089370
Skin fibrosis 14.71 9.34 22 537710 866 90089849
Primary hyperaldosteronism 14.71 9.34 8 537724 76 90090639
Infection susceptibility increased 14.70 9.34 54 537678 3872 90086843
Angiopathy 14.69 9.34 68 537664 5412 90085303
Anorexia nervosa 14.67 9.34 13 537719 286 90090429
Sickle cell anaemia with crisis 14.66 9.34 13 537719 7284 90083431
Hepatic neoplasm 14.63 9.34 37 537695 2161 90088554
Coronary artery stenosis 14.60 9.34 66 537666 5200 90085515
Haemolytic anaemia 14.57 9.34 119 537613 11578 90079137
Peripheral vascular disorder 14.52 9.34 76 537656 6355 90084360
Coma scale abnormal 14.48 9.34 69 537663 5557 90085158
Rheumatoid factor negative 14.47 9.34 18 537714 593 90090122
Sepsis 14.44 9.34 1247 536485 178567 89912148
Periorbital oedema 14.44 9.34 79 537653 6720 90083995
Enterochromaffin cell hyperplasia 14.43 9.34 7 537725 51 90090664
Posterior reversible encephalopathy syndrome 14.42 9.34 199 537533 22140 90068575
Congenital anomaly 14.40 9.34 10 537722 6337 90084378
Sleep disorder due to a general medical condition 14.39 9.34 183 537549 44555 90046160
Joint effusion 14.37 9.34 64 537668 19646 90071069
Cerebrovascular arteriovenous malformation 14.36 9.34 8 537724 80 90090635
Mammary duct ectasia 14.31 9.34 4 537728 3 90090712
Peritoneal effluent leukocyte count increased 14.31 9.34 4 537728 3 90090712
Urinary occult blood 14.31 9.34 4 537728 3 90090712
Nodule 14.31 9.34 96 537636 26590 90064125
Peripheral artery stenosis 14.26 9.34 18 537714 602 90090113
Urogenital infection fungal 14.23 9.34 6 537726 30 90090685
Eye pain 14.22 9.34 353 537379 43815 90046900
Carcinoid tumour 14.21 9.34 15 537717 412 90090303
Adrenocortical carcinoma 14.21 9.34 7 537725 53 90090662
Blood phosphorus increased 14.20 9.34 57 537675 4261 90086454
Blood urine present 14.19 9.34 161 537571 17117 90073598
Vasculitic rash 14.19 9.34 28 537704 1382 90089333
Medication error 14.14 9.34 626 537106 84026 90006689
Hepatorenal failure 14.11 9.34 19 537713 678 90090037
Duodenal ulcer repair 14.10 9.34 7 537725 54 90090661
Cholecystitis 14.10 9.34 159 537573 16881 90073834
Tonsillar inflammation 14.08 9.34 9 537723 118 90090597
Accidental overdose 14.07 9.34 241 537491 28032 90062683
Ventricular internal diameter abnormal 14.07 9.34 6 537726 31 90090684
Head banging 14.07 9.34 15 537717 417 90090298
Oculomucocutaneous syndrome 14.06 9.34 10 537722 158 90090557
Sodium retention 14.06 9.34 10 537722 158 90090557
Glucose urine present 14.05 9.34 22 537710 902 90089813
Haematuria 14.00 9.34 288 537444 34649 90056066
Duodenal ulcer haemorrhage 13.96 9.34 40 537692 2516 90088199
Transfusion 13.94 9.34 162 537570 17326 90073389
Acute myeloid leukaemia 13.88 9.34 69 537663 20571 90070144
Dactylitis 13.87 9.34 3 537729 3870 90086845
Skin disorder 13.87 9.34 300 537432 36406 90054309
Psychogenic visual disorder 13.82 9.34 5 537727 15 90090700
Bifascicular block 13.82 9.34 9 537723 122 90090593
Autoimmune hepatitis 13.82 9.34 107 537625 10244 90080471
Adrenal adenoma 13.79 9.34 25 537707 1157 90089558
Blindness 13.79 9.34 228 537504 26340 90064375
Venous aneurysm 13.78 9.34 4 537728 4 90090711
Muscle spasticity 13.77 9.34 290 537442 35032 90055683
Adrenal neoplasm 13.75 9.34 15 537717 428 90090287
Maternal exposure during delivery 13.73 9.34 3 537729 3843 90086872
Internal haemorrhage 13.70 9.34 73 537659 6147 90084568
Parosmia 13.60 9.34 80 537652 6989 90083726
Interstitial granulomatous dermatitis 13.58 9.34 7 537725 59 90090656
Pain in jaw 13.57 9.34 377 537355 47608 90043107
Dermatitis 13.56 9.34 196 537536 22024 90068691
Myocardial oedema 13.53 9.34 15 537717 436 90090279
Tracheostomy 13.49 9.34 19 537713 708 90090007
Haemorrhagic cyst 13.46 9.34 12 537720 266 90090449
Pyuria 13.41 9.34 35 537697 2084 90088631
Toxic encephalopathy 13.37 9.34 93 537639 8606 90082109
Postoperative renal failure 13.33 9.34 9 537723 130 90090585
Therapeutic product effect increased 13.32 9.34 26 537706 1273 90089442
Toxic epidermal necrolysis 13.32 9.34 269 537463 32259 90058456
Fear of disease 13.30 9.34 28 537704 1448 90089267
Pregnancy with implant contraceptive 13.30 9.34 3 537729 3758 90086957
Peritoneal dialysis complication 13.28 9.34 26 537706 1276 90089439
Polypectomy 13.27 9.34 23 537709 1027 90089688
Psychomotor retardation 13.26 9.34 60 537672 4729 90085986
Eye irritation 13.26 9.34 279 537453 33699 90057016
New onset diabetes after transplantation 13.24 9.34 10 537722 174 90090541
Traumatic haemorrhage 13.21 9.34 17 537715 580 90090135
Concomitant disease aggravated 13.19 9.34 115 537617 11403 90079312
CD30 expression 13.19 9.34 7 537725 63 90090652
Bronchiectasis 13.17 9.34 78 537654 22252 90068463
Eye oedema 13.14 9.34 33 537699 1919 90088796
Depression 13.12 9.34 1572 536160 299029 89791686
Reaction to excipient 13.10 9.34 32 537700 1828 90088887
Albumin urine present 13.10 9.34 12 537720 276 90090439
Jaundice hepatocellular 13.07 9.34 6 537726 38 90090677
Ultrasound uterus abnormal 13.00 9.34 7 537725 65 90090650
Ventricular hypertrophy 13.00 9.34 47 537685 3344 90087371
Congenital diaphragmatic hernia 12.99 9.34 11 537721 227 90090488
Myasthenia gravis 12.98 9.34 77 537655 6748 90083967
Hyperparathyroidism primary 12.97 9.34 15 537717 457 90090258
Substance abuse 12.97 9.34 8 537724 5398 90085317
Acute graft versus host disease in skin 12.93 9.34 6 537726 4750 90085965
Aortic arteriosclerosis 12.92 9.34 84 537648 7600 90083115
Exposure via ingestion 12.92 9.34 40 537692 2627 90088088
Gastric cyst 12.91 9.34 8 537724 99 90090616
Cytokine release syndrome 12.90 9.34 105 537627 27868 90062847
Oesophageal food impaction 12.89 9.34 12 537720 282 90090433
Glomerulonephritis 12.86 9.34 38 537694 2432 90088283
Chest X-ray abnormal 12.85 9.34 62 537670 5020 90085695
Hyperinsulinaemia 12.82 9.34 9 537723 139 90090576
Small cell carcinoma 12.82 9.34 10 537722 183 90090532
Renal-limited thrombotic microangiopathy 12.79 9.34 11 537721 232 90090483
Blood sodium abnormal 12.79 9.34 20 537712 819 90089896
Yellow skin 12.79 9.34 40 537692 2641 90088074
Micturition urgency 12.79 9.34 112 537620 11121 90079594
Haemorrhoidal haemorrhage 12.79 9.34 64 537668 5259 90085456
Thrombosis 12.75 9.34 544 537188 72707 90018008
Change of bowel habit 12.73 9.34 36 537696 2247 90088468
Disturbance in attention 12.73 9.34 368 537364 46741 90043974
Spinal compression fracture 12.72 9.34 142 537590 15036 90075679
Accelerated hypertension 12.67 9.34 15 537717 469 90090246
Genital haemorrhage 12.67 9.34 20 537712 8682 90082033
Hepatitis 12.65 9.34 321 537411 70418 90020297
Embolism 12.65 9.34 98 537634 9383 90081332
Hypereosinophilic syndrome 12.61 9.34 13 537719 347 90090368
Eyelid oedema 12.61 9.34 114 537618 11420 90079295
Blood cholinesterase increased 12.57 9.34 6 537726 42 90090673
Congenital syphilitic osteochondritis 12.55 9.34 5 537727 21 90090694
Leukaemic infiltration renal 12.55 9.34 5 537727 21 90090694
Autoimmune blistering disease 12.53 9.34 4 537728 7 90090708
Vascular pseudoaneurysm 12.52 9.34 30 537702 1693 90089022
Muscle haemorrhage 12.51 9.34 46 537686 3300 90087415
Abdominal pain lower 12.50 9.34 250 537482 29927 90060788
Mitral valve stenosis 12.50 9.34 26 537706 1333 90089382
Chorea 12.49 9.34 34 537698 2076 90088639
Central nervous system lupus 12.45 9.34 26 537706 1337 90089378
Injection site rash 12.44 9.34 88 537644 24085 90066630
Diabetic neuropathy 12.44 9.34 57 537675 4517 90086198
Urine albumin/creatinine ratio 12.40 9.34 3 537729 0 90090715
Tongue abscess 12.40 9.34 3 537729 0 90090715
Biliary hamartoma 12.40 9.34 3 537729 0 90090715
Hypoinsulinaemia 12.40 9.34 3 537729 0 90090715
Peripheral nerve paresis 12.40 9.34 3 537729 0 90090715
Rhinorrhoea 12.40 9.34 642 537090 87674 90003041
Neck pain 12.39 9.34 551 537181 113412 89977303
Trigeminal neuralgia 12.38 9.34 53 537679 4078 90086637
Suspected product quality issue 12.33 9.34 14 537718 418 90090297
Muscle tightness 12.32 9.34 128 537604 13311 90077404
Dysphoria 12.32 9.34 11 537721 6143 90084572
Premature rupture of membranes 12.29 9.34 9 537723 5549 90085166
Skin neoplasm excision 12.26 9.34 30 537702 1716 90088999
Urinary casts present 12.25 9.34 8 537724 109 90090606
Optic nerve injury 12.24 9.34 17 537715 625 90090090
Gingival erythema 12.23 9.34 23 537709 1095 90089620
Diverticulitis 12.22 9.34 353 537379 44834 90045881
Cytomegalovirus infection 12.20 9.34 100 537632 26502 90064213
Retroperitoneal oedema 12.19 9.34 5 537727 23 90090692
Porphyrins urine increased 12.19 9.34 5 537727 23 90090692
Fibrous dysplasia of jaw 12.19 9.34 4 537728 8 90090707
Aplasia pure red cell 12.16 9.34 62 537670 5132 90085583
Iliac artery stenosis 12.15 9.34 7 537725 75 90090640
Device deployment issue 12.15 9.34 7 537725 4902 90085813
Vascular access site pain 12.13 9.34 15 537717 491 90090224
Hepatitis acute 12.11 9.34 108 537624 10779 90079936
Electrocardiogram ST-T segment abnormal 12.10 9.34 14 537718 427 90090288
Sinonasal obstruction 12.04 9.34 11 537721 252 90090463
Poor dental condition 12.04 9.34 15 537717 495 90090220
Eosinophilia 12.03 9.34 237 537495 28296 90062419
Embolic stroke 12.02 9.34 52 537680 4020 90086695
Cardiac valve sclerosis 12.02 9.34 5 537727 24 90090691
Product taste abnormal 12.01 9.34 37 537695 2423 90088292
Blood iron decreased 12.01 9.34 161 537571 17798 90072917
Gastric pH increased 12.01 9.34 6 537726 47 90090668
Chronic gastritis 12.00 9.34 49 537683 3692 90087023
Hyperplastic cholecystopathy 11.99 9.34 9 537723 155 90090560
Hair disorder 11.99 9.34 24 537708 1197 90089518
Arteriovenous fistula 11.97 9.34 13 537719 369 90090346
Congenital megaureter 11.95 9.34 8 537724 114 90090601
Diplopia 11.94 9.34 238 537494 28476 90062239
Diverticulum intestinal 11.93 9.34 94 537638 9048 90081667
Bradykinesia 11.91 9.34 75 537657 6713 90084002
Glaucoma 11.86 9.34 181 537551 20574 90070141
Pneumothorax traumatic 11.85 9.34 9 537723 158 90090557
Lichen planus 11.84 9.34 40 537692 2751 90087964
Pyelonephritis 11.84 9.34 185 537547 21131 90069584
Disturbance in social behaviour 11.83 9.34 5 537727 4183 90086532
Pneumonia bacterial 11.81 9.34 122 537610 12668 90078047
Water intoxication 11.79 9.34 16 537716 575 90090140
Ischaemic cerebral infarction 11.79 9.34 27 537705 1479 90089236
Haemorrhagic infarction 11.78 9.34 12 537720 316 90090399
Burning feet syndrome 11.71 9.34 8 537724 118 90090597
Carcinoid tumour of the stomach 11.71 9.34 9 537723 161 90090554
Alanine aminotransferase increased 11.69 9.34 834 536898 117504 89973211
Sexual dysfunction 11.68 9.34 7 537725 4797 90085918
Venoocclusive liver disease 11.65 9.34 11 537721 5982 90084733
Insulin C-peptide increased 11.55 9.34 7 537725 83 90090632
Cerebrovascular insufficiency 11.55 9.34 7 537725 83 90090632
Capillary disorder 11.54 9.34 8 537724 121 90090594
Facial nerve disorder 11.50 9.34 16 537716 589 90090126
Deep vein thrombosis 11.47 9.34 659 537073 90961 89999754
Hepatic pain 11.46 9.34 47 537685 3548 90087167
Back disorder 11.46 9.34 97 537635 25534 90065181
Kidney duplex 11.43 9.34 8 537724 123 90090592
Arterial rupture 11.43 9.34 13 537719 389 90090326
Intermittent claudication 11.42 9.34 30 537702 1793 90088922
Mouth haemorrhage 11.42 9.34 88 537644 8413 90082302
Nail discomfort 11.41 9.34 7 537725 85 90090630
Osteocalcin decreased 11.40 9.34 6 537726 53 90090662
Oesophageal carcinoma recurrent 11.40 9.34 5 537727 28 90090687
Hypertensive urgency 11.37 9.34 17 537715 669 90090046
Bundle branch block left 11.37 9.34 83 537649 7802 90082913
Bladder sphincter atony 11.36 9.34 10 537722 218 90090497
Renal cyst infection 11.32 9.34 8 537724 125 90090590
Cardiac pacemaker insertion 11.31 9.34 54 537678 4353 90086362
Cholecystitis chronic 11.31 9.34 26 537706 9800 90080915
Acquired cystic kidney disease 11.30 9.34 6 537726 54 90090661
Respiratory distress 11.30 9.34 307 537425 38639 90052076
Burn oesophageal 11.30 9.34 13 537719 394 90090321
Leg amputation 11.27 9.34 35 537697 2302 90088413
Emphysema 11.25 9.34 116 537616 12039 90078676
Ear discomfort 11.25 9.34 101 537631 10099 90080616
Cardiopulmonary failure 11.25 9.34 52 537680 4136 90086579
Small for dates baby 11.21 9.34 8 537724 4999 90085716
Anti-platelet antibody positive 11.21 9.34 6 537726 55 90090660
Refractory cytopenia with unilineage dysplasia 11.21 9.34 15 537717 532 90090183
Tricuspid valve incompetence 11.19 9.34 150 537582 16581 90074134
Parathyroid tumour benign 11.18 9.34 20 537712 916 90089799
Choroidal detachment 11.16 9.34 11 537721 278 90090437
Exposure to allergen 11.14 9.34 15 537717 535 90090180
Renal tubular atrophy 11.12 9.34 20 537712 920 90089795
Porphyrins stool increased 11.11 9.34 5 537727 30 90090685
Device use error 11.09 9.34 16 537716 7205 90083510
Aortic disorder 11.08 9.34 19 537713 841 90089874
Base excess decreased 11.06 9.34 7 537725 90 90090625
Oesophageal atresia 11.00 9.34 16 537716 614 90090101
Hypovolaemic shock 11 9.34 76 537656 7018 90083697
Carcinoembryonic antigen 11.00 9.34 7 537725 91 90090624
Cranial nerve disorder 10.98 9.34 17 537715 690 90090025
Chondroma 10.98 9.34 5 537727 31 90090684
Hypertonic bladder 10.96 9.34 53 537679 4295 90086420
Reaction to preservatives 10.95 9.34 10 537722 229 90090486
Calcification metastatic 10.95 9.34 9 537723 178 90090537
Small intestinal haemorrhage 10.94 9.34 34 537698 2237 90088478
Retinal haemorrhage 10.94 9.34 65 537667 5699 90085016
Angiotensin converting enzyme increased 10.93 9.34 7 537725 92 90090623
Anaemia of malignant disease 10.93 9.34 16 537716 618 90090097
Choroidal effusion 10.92 9.34 18 537714 771 90089944
Neurodegenerative disorder 10.92 9.34 13 537719 409 90090306
Dermatosis 10.91 9.34 16 537716 619 90090096
Petechiae 10.89 9.34 142 537590 15599 90075116
Aortic valve incompetence 10.89 9.34 72 537660 6552 90084163
Atrial pressure increased 10.85 9.34 5 537727 32 90090683
Occult blood positive 10.84 9.34 50 537682 3973 90086742
Haemolysis 10.83 9.34 87 537645 8423 90082292
Craniectomy 10.82 9.34 4 537728 13 90090702
Subcutaneous haematoma 10.81 9.34 30 537702 1853 90088862
Foreign body 10.80 9.34 36 537696 2458 90088257
Parathyroid hyperplasia 10.80 9.34 8 537724 135 90090580
Vascular resistance systemic decreased 10.80 9.34 8 537724 135 90090580
Product storage error 10.76 9.34 73 537659 20168 90070547
Glossitis 10.74 9.34 46 537686 3541 90087174
Joint injury 10.73 9.34 133 537599 32531 90058184
Bronchial secretion retention 10.73 9.34 4 537728 3611 90087104
Back pain 10.73 9.34 2086 535646 315089 89775626
Psychotic disorder 10.71 9.34 126 537606 31104 90059611
Oral candidiasis 10.68 9.34 147 537585 35308 90055407
Blood creatine phosphokinase MB increased 10.67 9.34 23 537709 1209 90089506
Cystic fibrosis 10.67 9.34 5 537727 3936 90086779
Cardiac dysfunction 10.67 9.34 46 537686 3551 90087164
Heat illness 10.66 9.34 11 537721 294 90090421
Diffuse large B-cell lymphoma refractory 10.65 9.34 29 537703 1771 90088944
Intracranial aneurysm 10.65 9.34 53 537679 4345 90086370
Retinopathy proliferative 10.60 9.34 6 537726 62 90090653
Ankylosing spondylitis 10.60 9.34 41 537691 13092 90077623
Cholangitis 10.59 9.34 76 537656 7106 90083609
Eye pruritus 10.58 9.34 236 537496 28791 90061924
Pancreatic cyst 10.57 9.34 33 537699 2177 90088538
Zinc deficiency 10.56 9.34 7 537725 98 90090617
Glomerulonephritis minimal lesion 10.53 9.34 12 537720 360 90090355
Pelvic neoplasm 10.50 9.34 12 537720 361 90090354
Basal cell carcinoma 10.50 9.34 266 537466 33123 90057592
Subclavian steal syndrome 10.48 9.34 5 537727 35 90090680
Gastrointestinal sounds abnormal 10.48 9.34 54 537678 4489 90086226
Dry throat 10.47 9.34 82 537650 7878 90082837
Oral pain 10.46 9.34 261 537471 32422 90058293
Pyometra 10.44 9.34 7 537725 100 90090615
Contrast media reaction 10.44 9.34 23 537709 1228 90089487
Basilar artery occlusion 10.42 9.34 9 537723 191 90090524
Neurofibrosarcoma 10.42 9.34 9 537723 191 90090524
Hypoalbuminaemia 10.42 9.34 142 537590 15755 90074960
Myeloproliferative neoplasm 10.40 9.34 16 537716 646 90090069
Arteriovenous fistula operation 10.40 9.34 10 537722 245 90090470
Pulmonary hypoplasia 10.40 9.34 12 537720 365 90090350
Vascular resistance systemic 10.39 9.34 4 537728 15 90090700
Bromhidrosis 10.39 9.34 4 537728 15 90090700
Pupil fixed 10.39 9.34 32 537700 2096 90088619
Pulmonary vascular disorder 10.37 9.34 12 537720 366 90090349
Immune reconstitution inflammatory syndrome 10.34 9.34 16 537716 7003 90083712
Cardiac index increased 10.34 9.34 3 537729 3 90090712
Leucine aminopeptidase increased 10.34 9.34 3 537729 3 90090712
Mixed dementia 10.34 9.34 3 537729 3 90090712
Ventricular flutter 10.34 9.34 3 537729 3 90090712
Blood immunoglobulin A abnormal 10.34 9.34 3 537729 3 90090712
Blood erythropoietin decreased 10.34 9.34 3 537729 3 90090712
Vertebral artery thrombosis 10.34 9.34 3 537729 3 90090712
Sputum retention 10.33 9.34 16 537716 650 90090065
Cerebral artery stenosis 10.31 9.34 15 537717 576 90090139
Oesophageal achalasia 10.29 9.34 16 537716 652 90090063
Retinal vein occlusion 10.29 9.34 36 537696 2520 90088195
Drug dose omission by device 10.28 9.34 29 537703 10202 90080513
Eye discharge 10.28 9.34 84 537648 8174 90082541
Blood thyroid stimulating hormone increased 10.27 9.34 91 537641 9064 90081651
Metabolic encephalopathy 10.27 9.34 72 537660 6680 90084035
Blood pH decreased 10.27 9.34 36 537696 2522 90088193
Alopecia scarring 10.27 9.34 9 537723 195 90090520
Graft versus host disease in skin 10.26 9.34 5 537727 3848 90086867
Glomerulosclerosis 10.26 9.34 14 537718 506 90090209
Upper-airway cough syndrome 10.25 9.34 136 537596 14999 90075716
Radioallergosorbent test positive 10.24 9.34 5 537727 37 90090678
Cytotoxic oedema 10.23 9.34 9 537723 196 90090519
Foot operation 10.21 9.34 24 537708 8977 90081738
Type I hypersensitivity 10.18 9.34 6 537726 4149 90086566
Glomerulonephritis proliferative 10.17 9.34 10 537722 252 90090463
Sensorimotor disorder 10.15 9.34 17 537715 738 90089977
Hyperparathyroidism 10.15 9.34 43 537689 3294 90087421
Gingival discolouration 10.14 9.34 11 537721 312 90090403
Wheezing 10.14 9.34 1247 536485 236833 89853882
Noninfectious peritonitis 10.13 9.34 8 537724 149 90090566
Urate nephropathy 10.13 9.34 8 537724 149 90090566
Ileocolostomy 10.13 9.34 5 537727 38 90090677
Oesophageal operation 10.13 9.34 5 537727 38 90090677
Vertebral artery occlusion 10.12 9.34 9 537723 199 90090516
Hepatic steatosis 10.09 9.34 289 537443 36656 90054059
Cholestatic liver injury 10.09 9.34 47 537685 3750 90086965
Blood glucose fluctuation 10.09 9.34 58 537674 5025 90085690
Extremity necrosis 10.09 9.34 30 537702 1927 90088788
Primary biliary cholangitis 10.07 9.34 24 537708 1350 90089365
Abdominal pain 10.05 9.34 2568 535164 393153 89697562
Arteriosclerosis coronary artery 10.04 9.34 94 537638 9509 90081206
Faeces hard 10.03 9.34 42 537690 3200 90087515
Congenital uterine anomaly 10.00 9.34 8 537724 152 90090563
Blood creatinine abnormal 10.00 9.34 50 537682 4107 90086608
Ureteric cancer 9.98 9.34 6 537726 70 90090645
Intestinal angioedema 9.98 9.34 18 537714 830 90089885
Ocular hyperaemia 9.97 9.34 267 537465 33531 90057184
Unevaluable event 9.92 9.34 409 537323 54439 90036276
Q fever 9.91 9.34 8 537724 154 90090561
Rectal obstruction 9.88 9.34 3 537729 4 90090711
Gastric adenoma 9.88 9.34 3 537729 4 90090711
Actinomycotic pulmonary infection 9.88 9.34 3 537729 4 90090711
Malignant melanoma of eyelid 9.88 9.34 3 537729 4 90090711
Product coating issue 9.87 9.34 7 537725 110 90090605
Dilatation atrial 9.86 9.34 30 537702 1951 90088764
Nerve compression 9.86 9.34 101 537631 10465 90080250
Insomnia 9.83 9.34 1785 535947 331689 89759026
Skin hypertrophy 9.83 9.34 45 537687 3565 90087150
Continuous haemodiafiltration 9.82 9.34 19 537713 924 90089791
Female sexual arousal disorder 9.81 9.34 5 537727 41 90090674
Renal aneurysm 9.81 9.34 5 537727 41 90090674
Restrictive cardiomyopathy 9.81 9.34 11 537721 324 90090391
Lower gastrointestinal haemorrhage 9.78 9.34 88 537644 8804 90081911
Resorption bone increased 9.71 9.34 22 537710 1197 90089518
Salivary gland enlargement 9.68 9.34 12 537720 394 90090321
Nutritional condition abnormal 9.67 9.34 19 537713 935 90089780
Nipple exudate bloody 9.66 9.34 7 537725 114 90090601
Glucose urine 9.65 9.34 4 537728 19 90090696
Prinzmetal angina 9.62 9.34 20 537712 1025 90089690
Serum serotonin increased 9.61 9.34 9 537723 213 90090502
Mucosal membrane hyperplasia 9.61 9.34 5 537727 43 90090672
Coronary artery surgery 9.61 9.34 5 537727 43 90090672
Immobile 9.60 9.34 68 537664 6330 90084385
Status epilepticus 9.57 9.34 69 537663 18805 90071910
Peripheral ischaemia 9.56 9.34 62 537670 5605 90085110
Wound haemorrhage 9.55 9.34 38 537694 2829 90087886
Acute graft versus host disease 9.55 9.34 11 537721 5457 90085258
Lacrimation increased 9.54 9.34 219 537513 26843 90063872
Femoral artery embolism 9.52 9.34 5 537727 44 90090671
Vitreous floaters 9.51 9.34 77 537655 7472 90083243
Tendonitis 9.50 9.34 81 537651 21291 90069424
Vulval neoplasm 9.49 9.34 3 537729 5 90090710
Pain threshold decreased 9.49 9.34 3 537729 5 90090710
Blood chloride increased 9.48 9.34 41 537691 3169 90087546
Drug level above therapeutic 9.47 9.34 63 537669 5746 90084969
Peripheral artery occlusion 9.45 9.34 25 537707 1501 90089214
Pulmonary congestion 9.44 9.34 165 537567 19268 90071447
Blood potassium abnormal 9.43 9.34 39 537693 2955 90087760
Treatment noncompliance 9.42 9.34 386 537346 51341 90039374
Patient dissatisfaction with treatment 9.42 9.34 11 537721 339 90090376
Maternal drugs affecting foetus 9.41 9.34 10 537722 5145 90085570
Amylase increased 9.38 9.34 73 537659 6999 90083716
Upper respiratory tract inflammation 9.38 9.34 36 537696 2636 90088079
Urine flow decreased 9.38 9.34 12 537720 407 90090308
Impaired quality of life 9.34 9.34 191 537541 22953 90067762

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1182.31 11.23 2815 420229 93650 42104641
Off label use 577.40 11.23 3846 419198 634489 41563802
Drug ineffective 567.91 11.23 3801 419243 626396 41571895
Gingival hypertrophy 553.79 11.23 329 422715 2110 42196181
Distributive shock 528.73 11.23 322 422722 2174 42196117
Intentional overdose 493.41 11.23 1370 421674 50086 42148205
Drug abuse 427.21 11.23 255 422789 104516 42093775
Shock 348.74 11.23 843 422201 28278 42170013
Hypotension 340.27 11.23 3980 419064 253651 41944640
Blood pressure inadequately controlled 272.81 11.23 227 422817 2641 42195650
Bradycardia 270.44 11.23 1610 421434 83874 42114417
Acute kidney injury 238.49 11.23 5035 418009 362302 41835989
Neutropenia 231.19 11.23 1105 421939 198326 41999965
Foetal exposure during pregnancy 227.79 11.23 92 422952 47219 42151072
Blood pressure increased 223.52 11.23 1754 421290 100174 42098117
Hypertensive crisis 218.51 11.23 376 422668 9830 42188461
Oedema peripheral 218.02 11.23 2186 420858 133890 42064401
Treatment failure 213.82 11.23 184 422860 62440 42135851
Product use in unapproved indication 210.87 11.23 1027 422017 183429 42014862
Non-cardiogenic pulmonary oedema 201.58 11.23 122 422922 813 42197478
Angioedema 178.47 11.23 865 422179 41612 42156679
Myelosuppression 168.33 11.23 96 422948 40365 42157926
Vasoplegia syndrome 167.73 11.23 167 422877 2488 42195803
Febrile neutropenia 166.37 11.23 1119 421925 184584 42013707
Suspected suicide 155.10 11.23 245 422799 5954 42192337
Disease progression 151.00 11.23 823 422221 142833 42055458
Death 149.43 11.23 3551 419493 467634 41730657
Metabolic acidosis 147.75 11.23 951 422093 50907 42147384
BRASH syndrome 140.41 11.23 128 422916 1697 42196594
Cerebral infarction 139.86 11.23 647 422397 30522 42167769
Syncope 137.60 11.23 1551 421493 97855 42100436
Blood creatinine increased 134.48 11.23 1676 421368 108327 42089964
Suicide attempt 132.31 11.23 847 422197 45253 42153038
Hyperkalaemia 131.36 11.23 1298 421746 79160 42119131
Drug ineffective for unapproved indication 131.02 11.23 159 422885 46004 42152287
Angina pectoris 129.03 11.23 657 422387 32239 42166052
Hypokalaemia 125.44 11.23 1174 421870 70547 42127744
Lactic acidosis 124.65 11.23 823 422221 44438 42153853
Drug resistance 123.89 11.23 95 422949 34153 42164138
Renal impairment 122.78 11.23 1651 421393 108577 42089714
Thrombocytopenia 113.92 11.23 1273 421771 189006 42009285
Pancytopenia 109.64 11.23 701 422343 117042 42081249
Drug dependence 106.14 11.23 80 422964 29014 42169277
Rhabdomyolysis 99.77 11.23 1199 421845 76820 42121471
Dizziness 94.95 11.23 3188 419856 246066 41952225
Premature baby 91.99 11.23 58 422986 23095 42175196
Cerebrovascular accident 91.37 11.23 1413 421631 95747 42102544
Condition aggravated 90.02 11.23 1938 421106 258816 41939475
Orthostatic hypotension 89.76 11.23 565 422479 30005 42168286
Swollen tongue 87.47 11.23 430 422614 20801 42177490
Sedation 85.38 11.23 106 422938 30369 42167922
Leukopenia 83.63 11.23 419 422625 74327 42123964
Drug use disorder 82.47 11.23 5 423039 10328 42187963
Chronic kidney disease 80.93 11.23 770 422274 46471 42151820
Blood pressure systolic increased 77.25 11.23 509 422535 27459 42170832
Immune reconstitution inflammatory syndrome 75.02 11.23 7 423037 10136 42188155
Product use issue 75.02 11.23 450 422594 76301 42121990
Cytokine release syndrome 75.02 11.23 211 422833 44316 42153975
Hypertension 74.24 11.23 2179 420865 165025 42033266
Pyrexia 73.89 11.23 3179 419865 390863 41807428
Lip swelling 72.94 11.23 378 422666 18675 42179616
Sepsis 72.71 11.23 1468 421576 197866 42000425
Overdose 72.53 11.23 1457 421587 103807 42094484
Septic shock 70.67 11.23 576 422468 91096 42107195
Erectile dysfunction 69.17 11.23 454 422590 24459 42173832
Aggression 68.83 11.23 217 422827 43946 42154345
Sinus bradycardia 67.12 11.23 309 422735 14544 42183747
Proteinuria 65.75 11.23 422 422622 22561 42175730
Coronary artery disease 65.37 11.23 818 422226 52902 42145389
Gingival swelling 65.34 11.23 75 422969 1325 42196966
Pathogen resistance 64.36 11.23 17 423027 11433 42186858
Pulmonary oedema 63.04 11.23 807 422237 52465 42145826
Infection 62.62 11.23 761 422283 111307 42086984
Renal failure 62.41 11.23 1868 421176 141858 42056433
Infusion related reaction 62.36 11.23 351 422693 60455 42137836
Post transplant lymphoproliferative disorder 60.75 11.23 9 423035 9111 42189180
Gastrointestinal tract mucosal pigmentation 59.63 11.23 48 422996 531 42197760
Progressive multifocal leukoencephalopathy 59.62 11.23 20 423024 11516 42186775
Hypomagnesaemia 58.41 11.23 483 422561 28005 42170286
Myocardial infarction 58.02 11.23 1627 421417 122382 42075909
Therapy partial responder 57.82 11.23 68 422976 19953 42178338
Acute graft versus host disease 57.36 11.23 7 423037 8208 42190083
Seizure 57.09 11.23 847 422197 119714 42078577
Synovitis 56.53 11.23 43 423001 15524 42182767
Toxicity to various agents 56.04 11.23 2796 420248 226340 41971951
Rheumatoid arthritis 55.82 11.23 224 422820 42216 42156075
Chronic pigmented purpura 55.12 11.23 28 423016 125 42198166
Transient ischaemic attack 54.38 11.23 543 422501 33196 42165095
C-reactive protein abnormal 53.50 11.23 13 423031 9248 42189043
Cytomegalovirus infection reactivation 53.36 11.23 22 423022 11156 42187135
Cardiac failure congestive 52.82 11.23 1166 421878 84436 42113855
No adverse event 52.56 11.23 204 422840 38817 42159474
Nocturia 51.82 11.23 248 422796 11864 42186427
Multiple-drug resistance 51.72 11.23 6 423038 7316 42190975
Myalgia 51.39 11.23 1283 421761 94797 42103494
Bronchopulmonary aspergillosis 50.92 11.23 71 422973 19358 42178933
Glycosylated haemoglobin increased 50.58 11.23 258 422786 12666 42185625
Acute myocardial infarction 50.54 11.23 835 422209 57330 42140961
Carotid artery stenosis 49.37 11.23 142 422902 5294 42192997
Breath sounds abnormal 49.15 11.23 244 422800 11849 42186442
Interstitial lung disease 48.80 11.23 1070 421974 77392 42120899
Haematotoxicity 48.72 11.23 24 423020 10961 42187330
Cytomegalovirus infection 48.08 11.23 162 422882 32144 42166147
Psychotic disorder 48.03 11.23 140 422904 29068 42169223
Neutrophil count decreased 47.70 11.23 401 422643 63014 42135277
Exposure during pregnancy 47.46 11.23 13 423031 8535 42189756
Renal cell carcinoma 47.13 11.23 141 422903 5376 42192915
Infective pulmonary exacerbation of cystic fibrosis 47.11 11.23 10 423034 7808 42190483
Aspergillus infection 46.59 11.23 53 422991 15784 42182507
Haemophagocytic lymphohistiocytosis 46.36 11.23 68 422976 18154 42180137
Tachycardia 46.20 11.23 715 422329 100372 42097919
Joint swelling 45.66 11.23 938 422106 67084 42131207
Palmar-plantar erythrodysaesthesia syndrome 45.48 11.23 355 422689 20227 42178064
Atrioventricular block complete 45.27 11.23 228 422816 11136 42187155
Chronic graft versus host disease 44.99 11.23 4 423040 6021 42192270
Thalamus haemorrhage 44.10 11.23 55 422989 1064 42197227
Multiple organ dysfunction syndrome 43.78 11.23 688 422356 96347 42101944
Intercepted product preparation error 43.42 11.23 10 423034 7379 42190912
Fall 43.02 11.23 2788 420256 231732 41966559
Nephrotic syndrome 42.88 11.23 186 422858 8532 42189759
Periodontitis 42.86 11.23 78 422966 2133 42196158
Primary hyperaldosteronism 41.74 11.23 25 423019 163 42198128
Product monitoring error 41.60 11.23 117 422927 4306 42193985
Mucosal inflammation 41.42 11.23 303 422741 49071 42149220
Hyperdynamic left ventricle 41.42 11.23 29 423015 255 42198036
Mucormycosis 41.32 11.23 10 423034 7133 42191158
Pemphigoid 40.82 11.23 223 422821 11244 42187047
Therapeutic product effect decreased 40.68 11.23 225 422819 38925 42159366
Candida infection 40.53 11.23 97 422947 21513 42176778
Device leakage 40.53 11.23 26 423018 10259 42188032
Hyponatraemia 40.38 11.23 1305 421739 100157 42098134
Spirometry abnormal 39.58 11.23 3 423041 5143 42193148
Renin increased 39.20 11.23 25 423019 185 42198106
Akathisia 39.07 11.23 28 423016 10423 42187868
Bone marrow failure 39.04 11.23 182 422862 32911 42165380
Carotid arteriosclerosis 38.70 11.23 77 422967 2255 42196036
Palpitations 38.66 11.23 714 422330 50083 42148208
Congenital hiatus hernia 38.62 11.23 142 422902 6032 42192259
Dyspnoea exertional 38.56 11.23 706 422338 49442 42148849
Adenovirus infection 38.48 11.23 10 423034 6799 42191492
Graft versus host disease 38.30 11.23 43 423001 12882 42185409
Intentional product use issue 38.15 11.23 493 422551 71340 42126951
Product dose omission issue 37.85 11.23 1205 421839 153160 42045131
Renal artery stenosis 37.85 11.23 76 422968 2241 42196050
Agitation 37.72 11.23 432 422612 63882 42134409
Therapeutic product effect incomplete 37.63 11.23 487 422557 70452 42127839
Mycotic allergy 37.20 11.23 3 423041 4888 42193403
Blood creatine phosphokinase increased 36.99 11.23 680 422364 47658 42150633
Therapy non-responder 36.79 11.23 345 422699 53014 42145277
Drug intolerance 36.69 11.23 569 422475 79855 42118436
Hospitalisation 36.63 11.23 518 422526 73812 42124479
Maternal exposure during pregnancy 36.23 11.23 12 423032 6966 42191325
Loss of consciousness 36.00 11.23 1185 421859 91169 42107122
Gingival bleeding 35.77 11.23 173 422871 8312 42189979
Neurotoxicity 35.60 11.23 118 422926 23533 42174758
Psoriatic arthropathy 35.27 11.23 128 422916 24839 42173452
Wrong technique in product usage process 35.12 11.23 263 422781 42372 42155919
Diffuse large B-cell lymphoma recurrent 34.52 11.23 4 423040 4882 42193409
Hypertensive heart disease 34.49 11.23 78 422966 2502 42195789
Diastolic dysfunction 34.36 11.23 149 422895 6834 42191457
Dermatomyositis 33.18 11.23 59 422985 1584 42196707
Micturition urgency 33.13 11.23 217 422827 11681 42186610
5-hydroxyindolacetic acid in urine increased 33.11 11.23 22 423022 176 42198115
Substance abuse 33.10 11.23 24 423020 8881 42189410
Neuropathy peripheral 32.76 11.23 765 422279 101088 42097203
Bone erosion 32.67 11.23 3 423041 4400 42193891
Diabetes mellitus inadequate control 32.66 11.23 263 422781 15127 42183164
Staphylococcal infection 32.55 11.23 229 422815 37414 42160877
Blood mercury abnormal 32.54 11.23 25 423019 257 42198034
Suicidal ideation 32.52 11.23 313 422731 47848 42150443
Sinusitis 32.50 11.23 306 422738 46986 42151305
Hypoglycaemia 32.50 11.23 801 422243 59053 42139238
Sprue-like enteropathy 32.48 11.23 36 423008 611 42197680
Glomerular filtration rate decreased 32.33 11.23 275 422769 16076 42182215
Atrioventricular block first degree 32.32 11.23 139 422905 6352 42191939
Hyperglycaemia 31.96 11.23 636 422408 45223 42153068
Allergy to animal 31.83 11.23 33 423011 517 42197774
Neuritis 31.77 11.23 11 423033 6209 42192082
Hepatic cytolysis 31.44 11.23 148 422896 26696 42171595
Paranoia 31.33 11.23 57 422987 13969 42184322
Eosinophilic granulomatosis with polyangiitis 31.18 11.23 24 423020 8614 42189677
Anxiety 31.13 11.23 917 422127 117643 42080648
Febrile bone marrow aplasia 31.13 11.23 33 423011 10148 42188143
Injection site pain 30.94 11.23 396 422648 57402 42140889
Acute myeloid leukaemia 30.85 11.23 115 422929 22141 42176150
Venoocclusive liver disease 30.82 11.23 34 423010 10268 42188023
Cardiogenic shock 30.71 11.23 511 422533 35129 42163162
Fungal infection 30.66 11.23 97 422947 19625 42178666
Peripheral swelling 30.39 11.23 1139 421905 89131 42109160
Myocardial depression 30.22 11.23 18 423026 116 42198175
Angina unstable 30.20 11.23 206 422838 11242 42187049
Irritability 30.13 11.23 160 422884 27968 42170323
Abnormal behaviour 29.73 11.23 148 422896 26303 42171988
Dystonia 29.45 11.23 51 422993 12739 42185552
Acute hepatic failure 29.42 11.23 80 422964 16993 42181298
Diabetic nephropathy 29.34 11.23 69 422975 2272 42196019
Small for dates baby 29.23 11.23 8 423036 5255 42193036
Gout 29.07 11.23 415 422629 27640 42170651
Malignant melanoma in situ 28.82 11.23 76 422968 2691 42195600
Drug withdrawal syndrome 28.80 11.23 113 422931 21436 42176855
Viral infection 28.72 11.23 120 422924 22363 42175928
Tongue oedema 28.66 11.23 85 422959 3225 42195066
Chronic obstructive pulmonary disease 28.63 11.23 825 422219 62289 42136002
Device issue 28.33 11.23 57 422987 13452 42184839
Milk-alkali syndrome 28.26 11.23 35 423009 672 42197619
Epstein-Barr virus infection 28.07 11.23 33 423011 9685 42188606
Hypertensive emergency 28.04 11.23 48 422996 1249 42197042
Obsessive-compulsive disorder 28.04 11.23 16 423028 6727 42191564
Lymphocele 28.02 11.23 53 422991 1494 42196797
Heart rate decreased 27.97 11.23 514 422530 36018 42162273
Nodule 27.94 11.23 51 422993 12483 42185808
Nausea 27.91 11.23 3481 419563 393318 41804973
Ventricular septal defect 27.83 11.23 5 423039 4394 42193897
Hepatojugular reflux 27.77 11.23 34 423010 645 42197646
Cerebral haemorrhage 27.69 11.23 542 422502 38424 42159867
BK virus infection 27.39 11.23 28 423016 8756 42189535
Electrocardiogram Q wave abnormal 27.30 11.23 30 423014 504 42197787
Clear cell renal cell carcinoma 27.16 11.23 47 422997 1234 42197057
Peripheral arterial occlusive disease 27.10 11.23 137 422907 6701 42191590
Hypercholesterolaemia 26.95 11.23 219 422825 12630 42185661
Renal function test abnormal 26.94 11.23 79 422965 2978 42195313
Blood pressure decreased 26.88 11.23 764 422280 57568 42140723
Chills 26.88 11.23 719 422325 93347 42104944
Accelerated hypertension 26.80 11.23 23 423021 280 42198011
Aortic dissection 26.70 11.23 79 422965 2993 42195298
Vertebral osteophyte 26.69 11.23 13 423031 52 42198239
Depression 26.64 11.23 872 422172 110491 42087800
Macroglossia 26.59 11.23 29 423015 483 42197808
Hyperplasia 26.52 11.23 34 423010 677 42197614
Graft versus host disease in gastrointestinal tract 26.43 11.23 9 423035 5134 42193157
Metastatic renal cell carcinoma 26.08 11.23 63 422981 2111 42196180
COVID-19 25.85 11.23 916 422128 115032 42083259
Cytomegalovirus chorioretinitis 25.63 11.23 7 423037 4604 42193687
Vomiting 25.57 11.23 2502 420542 287221 41911070
Lymphadenopathy 25.53 11.23 210 422834 33155 42165136
Lymphoma 25.52 11.23 66 422978 14255 42184036
Psychomotor skills impaired 25.24 11.23 10 423034 5194 42193097
Swelling face 25.21 11.23 399 422645 27155 42171136
Myelodysplastic syndrome 25.14 11.23 128 422916 22617 42175674
Gravitational oedema 25.07 11.23 33 423011 675 42197616
Pollakiuria 24.97 11.23 337 422707 22168 42176123
Melaena 24.91 11.23 531 422513 38215 42160076
Pelvic mass 24.86 11.23 20 423024 221 42198070
Lacunar infarction 24.78 11.23 80 422964 3180 42195111
Status epilepticus 24.65 11.23 76 422968 15502 42182789
Conjunctivitis allergic 24.61 11.23 14 423030 5897 42192394
Drug effective for unapproved indication 24.50 11.23 18 423026 6615 42191676
Hypocalcaemia 24.33 11.23 428 422616 29745 42168546
Pulmonary embolism 24.20 11.23 956 422088 118656 42079635
Zoonotic bacterial infection 24.14 11.23 13 423031 67 42198224
Carotid sinus syndrome 23.95 11.23 10 423034 25 42198266
Miosis 23.93 11.23 62 422982 13384 42184907
Graft versus host disease in skin 23.70 11.23 11 423033 5201 42193090
Hepatic neoplasm 23.66 11.23 61 422983 2130 42196161
Venoocclusive disease 23.61 11.23 5 423039 3910 42194381
Low birth weight baby 23.56 11.23 39 423005 9916 42188375
Atrial fibrillation 23.50 11.23 1648 421396 137945 42060346
Brain stem infarction 23.39 11.23 45 422999 1285 42197006
Cytomegalovirus viraemia 23.33 11.23 42 423002 10335 42187956
Appendicolith 23.23 11.23 63 422981 13393 42184898
Therapeutic response decreased 23.14 11.23 245 422799 36767 42161524
Ventricular hypertrophy 23.11 11.23 102 422942 4714 42193577
Orbital myositis 22.82 11.23 16 423028 141 42198150
Ear infection 22.82 11.23 59 422985 12745 42185546
Gait spastic 22.76 11.23 46 422998 1363 42196928
Plasmapheresis 22.75 11.23 25 423019 420 42197871
Microalbuminuria 22.50 11.23 35 423009 839 42197452
Asthma 22.37 11.23 792 422252 61522 42136769
Alveolitis 22.33 11.23 54 422990 1811 42196480
Nephrogenic systemic fibrosis 22.30 11.23 81 422963 3420 42194871
Oedema 22.30 11.23 675 422369 51326 42146965
Cerebellar haemorrhage 22.29 11.23 51 422993 1649 42196642
Stenosis 22.18 11.23 58 422986 2043 42196248
Putamen haemorrhage 22.07 11.23 20 423024 263 42198028
Acidosis 21.95 11.23 202 422842 12077 42186214
Electrocardiogram QRS complex prolonged 21.92 11.23 115 422929 5708 42192583
Arthropathy 21.87 11.23 188 422856 29409 42168882
Left ventricular hypertrophy 21.85 11.23 163 422881 9156 42189135
Retinopathy hypertensive 21.84 11.23 21 423023 299 42197992
Oropharyngeal oedema 21.80 11.23 13 423031 84 42198207
Hyperlipidaemia 21.78 11.23 317 422727 21199 42177092
Drug dose omission by device 21.70 11.23 16 423028 5870 42192421
Body temperature increased 21.69 11.23 116 422928 20242 42178049
Thrombotic cerebral infarction 21.68 11.23 25 423019 444 42197847
Dermatitis atopic 21.64 11.23 203 422841 12201 42186090
Pseudomonas infection 21.60 11.23 83 422961 15840 42182451
Chest pain 21.40 11.23 1635 421409 137895 42060396
Pseudolymphoma 21.33 11.23 30 423014 655 42197636
Atrioventricular block 21.33 11.23 166 422878 9449 42188842
Blood urea increased 21.27 11.23 450 422594 32343 42165948
Tenosynovitis 21.21 11.23 10 423034 4685 42193606
Dyskinesia 21.20 11.23 156 422888 25234 42173057
Haemodynamic instability 21.16 11.23 204 422840 12353 42185938
Haemorrhage subcutaneous 21.08 11.23 66 422978 2580 42195711
Red blood cell sedimentation rate abnormal 20.99 11.23 6 423038 3830 42194461
Lung diffusion test decreased 20.97 11.23 34 423010 845 42197446
Yellow skin 20.90 11.23 61 422983 2293 42195998
Polymyositis 20.87 11.23 51 422993 1722 42196569
Euphoric mood 20.77 11.23 20 423024 6433 42191858
Asthma-chronic obstructive pulmonary disease overlap syndrome 20.69 11.23 47 422997 1512 42196779
Psychiatric decompensation 20.66 11.23 8 423036 4214 42194077
Viral mutation identified 20.62 11.23 4 423040 3327 42194964
Hydronephrosis 20.61 11.23 194 422850 11671 42186620
Renal disorder 20.56 11.23 403 422641 28577 42169714
Fibrillary glomerulonephritis 20.53 11.23 11 423033 56 42198235
Benign prostatic hyperplasia 20.47 11.23 308 422736 20744 42177547
Blood glucose increased 20.45 11.23 911 422133 72788 42125503
Coronary artery stenosis 20.23 11.23 174 422870 10205 42188086
Mydriasis 20.16 11.23 35 423009 8735 42189556
Acute graft versus host disease in intestine 20.16 11.23 7 423037 3944 42194347
Intentional self-injury 20.13 11.23 80 422964 15122 42183169
Atheroembolism 20.11 11.23 21 423023 332 42197959
Haemodialysis 19.99 11.23 172 422872 10088 42188203
Disease recurrence 19.98 11.23 193 422851 29485 42168806
Apparent death 19.92 11.23 6 423038 3702 42194589
Glomerular filtration rate abnormal 19.91 11.23 40 423004 1180 42197111
Sickle cell anaemia with crisis 19.77 11.23 12 423032 4878 42193413
Polyomavirus-associated nephropathy 19.77 11.23 16 423028 5599 42192692
Mouth swelling 19.75 11.23 58 422986 2188 42196103
Bradyarrhythmia 19.75 11.23 65 422979 2610 42195681
Pneumonia 19.73 11.23 3792 419252 418357 41779934
Dyspnoea at rest 19.65 11.23 89 422955 4160 42194131
Product solubility abnormal 19.63 11.23 27 423017 577 42197714
Cytopenia 19.60 11.23 98 422946 17399 42180892
Inspiratory capacity decreased 19.60 11.23 3 423041 2964 42195327
Acute graft versus host disease in skin 19.58 11.23 27 423017 7397 42190894
Strongyloidiasis 19.46 11.23 5 423039 3426 42194865
Hypoinsulinaemia 19.33 11.23 6 423038 3 42198288
Intentional product misuse 19.32 11.23 467 422577 61433 42136858
Drug interaction 19.27 11.23 2975 420069 264024 41934267
Total lung capacity abnormal 19.26 11.23 10 423034 4433 42193858
Maternal drugs affecting foetus 19.25 11.23 7 423037 3832 42194459
Low density lipoprotein decreased 19.22 11.23 41 423003 1263 42197028
Physical deconditioning 19.17 11.23 60 422984 2345 42195946
Diabetic neuropathy 19.13 11.23 92 422952 4410 42193881
Dyspnoea 18.92 11.23 4805 418239 437816 41760475
Hepatic function abnormal 18.90 11.23 657 422387 50910 42147381
Peripheral artery stenosis 18.87 11.23 33 423011 874 42197417
Neuroleptic malignant syndrome 18.87 11.23 130 422914 21342 42176949
Peripheral artery occlusion 18.86 11.23 50 422994 1776 42196515
Blood pressure diastolic decreased 18.71 11.23 171 422873 10204 42188087
Cognitive disorder 18.70 11.23 233 422811 33939 42164352
Seronegative arthritis 18.64 11.23 39 423005 1185 42197106
Dysmorphism 18.49 11.23 5 423039 3311 42194980
Band neutrophil percentage decreased 18.49 11.23 7 423037 12 42198279
Drug eruption 18.49 11.23 327 422717 22748 42175543
Hepatocellular carcinoma 18.47 11.23 142 422902 8052 42190239
Bronchiectasis 18.45 11.23 266 422778 17753 42180538
Nipple inflammation 18.35 11.23 10 423034 53 42198238
Osteonecrosis 18.27 11.23 88 422956 15777 42182514
Blood urea abnormal 18.20 11.23 37 423007 1101 42197190
Diffuse large B-cell lymphoma 18.08 11.23 42 423002 9412 42188879
Drug reaction with eosinophilia and systemic symptoms 18.07 11.23 301 422743 41774 42156517
Forced vital capacity decreased 18.02 11.23 33 423011 907 42197384
Pericardial disease 17.97 11.23 24 423020 498 42197793
Tubulointerstitial nephritis 17.97 11.23 425 422619 31123 42167168
Bundle branch block left 17.96 11.23 118 422926 6358 42191933
Muscle necrosis 17.94 11.23 35 423009 1010 42197281
Gastric ulcer haemorrhage 17.83 11.23 113 422931 6014 42192277
Oesophageal carcinoma 17.81 11.23 44 423000 9652 42188639
Lipodystrophy acquired 17.79 11.23 6 423038 3444 42194847
Electrocardiogram J wave 17.75 11.23 9 423035 40 42198251
Needle fatigue 17.72 11.23 38 423006 1175 42197116
Intervertebral disc displacement 17.71 11.23 13 423031 124 42198167
Hypertonic bladder 17.71 11.23 58 422986 2323 42195968
White blood cell count decreased 17.70 11.23 905 422139 109491 42088800
Hyperbilirubinaemia 17.61 11.23 126 422918 20509 42177782
Bundle branch block 17.55 11.23 34 423010 976 42197315
Mitral valve incompetence 17.52 11.23 245 422799 16244 42182047
Pericarditis uraemic 17.49 11.23 7 423037 15 42198276
Metastases to central nervous system 17.49 11.23 49 422995 10306 42187985
Duodenal ulcer haemorrhage 17.45 11.23 108 422936 5700 42192591
Blood lactic acid increased 17.40 11.23 138 422906 7901 42190390
Hypersensitivity vasculitis 17.34 11.23 71 422973 3173 42195118
Hyperuricaemia 17.33 11.23 156 422888 9268 42189023
Depressed level of consciousness 17.29 11.23 610 422434 47360 42150931
Respiratory depression 17.20 11.23 113 422931 18755 42179536
Blood potassium increased 17.18 11.23 269 422775 18267 42180024
Cachexia 17.16 11.23 34 423010 8070 42190221
Neurological symptom 17.08 11.23 47 422997 9944 42188347
Hypospadias 17.06 11.23 7 423037 3560 42194731
Abscess 17.01 11.23 78 422966 14170 42184121
Helicobacter gastritis 17.01 11.23 40 423004 1317 42196974
Neonatal respiratory distress syndrome 16.99 11.23 12 423032 4501 42193790
Myopathy 16.92 11.23 210 422834 13551 42184740
Hyperthermia malignant 16.86 11.23 3 423041 2655 42195636
Epstein-Barr virus infection reactivation 16.59 11.23 3 423041 2624 42195667
Malignant neoplasm progression 16.56 11.23 893 422151 107507 42090784
Immune effector cell-associated neurotoxicity syndrome 16.55 11.23 44 423000 9417 42188874
Eyelid oedema 16.55 11.23 105 422939 5590 42192701
Pharyngeal oedema 16.49 11.23 110 422934 5958 42192333
Osteoporosis 16.41 11.23 84 422960 14822 42183469
Varicose vein 16.37 11.23 43 423001 1519 42196772
Alanine aminotransferase abnormal 16.30 11.23 15 423029 4929 42193362
Alcohol abuse 16.28 11.23 10 423034 4039 42194252
Device related infection 16.27 11.23 126 422918 20153 42178138
Interstitial granulomatous dermatitis 16.27 11.23 15 423029 202 42198089
Acute coronary syndrome 16.25 11.23 222 422822 14643 42183648
Leukaemoid reaction 16.21 11.23 13 423031 143 42198148
Enterococcal infection 16.17 11.23 63 422981 11976 42186315
Incorrect dose administered 16.16 11.23 401 422643 52573 42145718
Vertigo 16.13 11.23 451 422593 33896 42164395
Atrial septal defect 16.11 11.23 34 423010 7885 42190406
Blood potassium decreased 16.02 11.23 288 422756 20096 42178195
Hyperthyroidism 16.02 11.23 215 422829 14126 42184165
Monoparesis 16.00 11.23 65 422979 2895 42195396
Intracranial haematoma 15.99 11.23 24 423020 557 42197734
Product substitution issue 15.97 11.23 177 422867 11113 42187178
Urine albumin/creatinine ratio increased 15.93 11.23 23 423021 515 42197776
Hyperammonaemia 15.81 11.23 34 423010 7832 42190459
Hepatic enzyme increased 15.81 11.23 340 422704 45444 42152847
Dissociation 15.81 11.23 9 423035 3789 42194502
Antipsychotic drug level below therapeutic 15.80 11.23 6 423038 3198 42195093
Autism spectrum disorder 15.76 11.23 5 423039 2983 42195308
Dyslalia 15.75 11.23 25 423019 610 42197681
Coma scale abnormal 15.73 11.23 88 422956 4477 42193814
Hyperammonaemic encephalopathy 15.68 11.23 4 423040 2754 42195537
Chest discomfort 15.65 11.23 777 422267 62839 42135452
Kidney small 15.63 11.23 9 423035 54 42198237
Drug level decreased 15.56 11.23 49 422995 9928 42188363
Intraventricular haemorrhage 15.52 11.23 78 422966 3806 42194485
Nodal rhythm 15.43 11.23 43 423001 1574 42196717
Neutropenic colitis 15.41 11.23 13 423031 4457 42193834
High density lipoprotein decreased 15.39 11.23 78 422966 3819 42194472
Discomfort 15.37 11.23 343 422701 24876 42173415
Stomatitis 15.35 11.23 381 422663 49948 42148343
Carcinoid tumour 15.32 11.23 16 423028 253 42198038
Cystitis haemorrhagic 15.31 11.23 31 423013 7298 42190993
Clostridium difficile colitis 15.25 11.23 136 422908 21116 42177175
Herbal interaction 15.23 11.23 20 423024 408 42197883
Tricuspid valve calcification 15.21 11.23 5 423039 4 42198287
Upper respiratory tract infection 15.21 11.23 311 422733 41862 42156429
Nervous system disorder 15.16 11.23 104 422940 17091 42181200
Blood pressure systolic decreased 15.15 11.23 93 422951 4894 42193397
Asphyxia 15.12 11.23 38 423006 8288 42190003
Contraindicated product administered 15.11 11.23 169 422875 25103 42173188
Potentiating drug interaction 15.09 11.23 113 422931 6355 42191936
Acute myeloid leukaemia recurrent 15.09 11.23 8 423036 3504 42194787
Prostatic specific antigen increased 15.07 11.23 244 422800 16681 42181610
Hereditary haemorrhagic telangiectasia 15.04 11.23 8 423036 40 42198251
Cardiomegaly 15.04 11.23 242 422802 16524 42181767
Immune-mediated myositis 15.04 11.23 76 422968 3717 42194574
Suture rupture 14.98 11.23 21 423023 457 42197834
Rhythm idioventricular 14.96 11.23 18 423026 335 42197956
Lipoma 14.94 11.23 51 422993 2087 42196204
Encephalitis toxic 14.93 11.23 16 423028 261 42198030
Coronary artery occlusion 14.92 11.23 171 422873 10826 42187465
Colitis 14.91 11.23 350 422694 46222 42152069
Blindness transient 14.88 11.23 61 422983 2728 42195563
Hypertensive encephalopathy 14.85 11.23 21 423023 461 42197830
Hyperaldosteronism 14.83 11.23 15 423029 228 42198063
Syringe issue 14.81 11.23 40 423004 8516 42189775
Bacteraemia 14.75 11.23 168 422876 24872 42173419
Rebound effect 14.75 11.23 32 423012 7347 42190944
Post concussion syndrome 14.71 11.23 13 423031 165 42198126
Liver carcinoma ruptured 14.69 11.23 16 423028 266 42198025
Giant cell arteritis 14.68 11.23 35 423009 1163 42197128
Juvenile idiopathic arthritis 14.68 11.23 4 423040 2635 42195656
Hepatic fibrosis 14.66 11.23 16 423028 4856 42193435
Snoring 14.64 11.23 78 422966 3895 42194396
Glomerulonephritis acute 14.53 11.23 12 423032 138 42198153
Occult blood 14.53 11.23 31 423013 955 42197336
Mucosal membrane hyperplasia 14.49 11.23 4 423040 0 42198291
Epinephrine increased 14.49 11.23 4 423040 0 42198291
Ventricular compliance decreased 14.49 11.23 4 423040 0 42198291
Dysgeusia 14.44 11.23 443 422601 33746 42164545
Muscle rigidity 14.41 11.23 66 422978 11993 42186298
Malaise 14.38 11.23 2356 420688 209800 41988491
Joint instability 14.37 11.23 22 423022 520 42197771
Blister 14.36 11.23 366 422678 27124 42171167
Dialysis 14.35 11.23 182 422862 11804 42186487
Hyperthermia 14.33 11.23 70 422974 12504 42185787
Diabetic retinopathy 14.23 11.23 49 422995 2014 42196277
Decreased appetite 14.15 11.23 2154 420890 190983 42007308
Unintentional medical device removal 14.11 11.23 7 423037 3184 42195107
Lacrimal disorder 14.11 11.23 17 423027 317 42197974
Thromboangiitis obliterans 14.10 11.23 6 423038 16 42198275
Anal fistula 14.10 11.23 25 423019 6188 42192103
Deep vein thrombosis 14.10 11.23 622 422422 76335 42121956
Hair colour changes 14.07 11.23 51 422993 2151 42196140
Electrocardiogram P wave abnormal 13.98 11.23 13 423031 177 42198114
Proctalgia 13.98 11.23 31 423013 7062 42191229
Pulmonary valve disease 13.95 11.23 19 423025 402 42197889
Obstructive airways disorder 13.93 11.23 333 422711 24426 42173865
Nephrectomy 13.93 11.23 29 423015 878 42197413
Granuloma annulare 13.93 11.23 13 423031 178 42198113
Prostate cancer stage IV 13.85 11.23 4 423040 2536 42195755
Pulmonary fibrosis 13.83 11.23 184 422860 26497 42171794
Gingival hypoplasia 13.81 11.23 5 423039 7 42198284
Pericardial haemorrhage 13.79 11.23 71 422973 3498 42194793
Hypovolaemic shock 13.77 11.23 139 422905 8520 42189771
Nasal crusting 13.75 11.23 21 423023 495 42197796
Renal transplant 13.70 11.23 54 422990 2371 42195920
Epiglottic oedema 13.64 11.23 13 423031 183 42198108
Lymphocyte count decreased 13.62 11.23 194 422850 27615 42170676
Aplastic anaemia 13.56 11.23 185 422859 12199 42186092
Klebsiella infection 13.55 11.23 62 422982 11270 42187021
Sinus node dysfunction 13.54 11.23 88 422956 4724 42193567
Hepatitis 13.53 11.23 190 422854 27110 42171181
Sedation complication 13.53 11.23 6 423038 2913 42195378
Relapsing-remitting multiple sclerosis 13.53 11.23 39 423005 1456 42196835
Presyncope 13.50 11.23 304 422740 22083 42176208
Somnolence 13.49 11.23 1211 421833 139894 42058397
Pelvic cyst 13.49 11.23 7 423037 33 42198258
Therapeutic product effect variable 13.48 11.23 7 423037 3102 42195189
Attention deficit hyperactivity disorder 13.47 11.23 7 423037 3101 42195190
Immunodeficiency 13.45 11.23 33 423011 7257 42191034
Skin toxicity 13.42 11.23 28 423016 6521 42191770
Infusion site extravasation 13.41 11.23 21 423023 5460 42192831
Macrophages increased 13.41 11.23 12 423032 155 42198136
Altered state of consciousness 13.41 11.23 383 422661 28876 42169415
Injection site reaction 13.41 11.23 96 422948 15625 42182666
Cardiac dysfunction 13.40 11.23 68 422976 3331 42194960
Thrombotic stroke 13.38 11.23 15 423029 258 42198033
Blood pressure abnormal 13.36 11.23 155 422889 9843 42188448
Echocardiogram abnormal 13.35 11.23 35 423009 1235 42197056
Anuria 13.34 11.23 174 422870 11358 42186933
Antipsychotic drug level increased 13.31 11.23 16 423028 4650 42193641
Virologic failure 13.30 11.23 12 423032 3982 42194309
Post-traumatic amnestic disorder 13.26 11.23 8 423036 53 42198238
Anticoagulation drug level abnormal 13.23 11.23 12 423032 158 42198133
Talipes 13.19 11.23 3 423041 2233 42196058
Deprescribing error 13.14 11.23 6 423038 20 42198271
Anal inflammation 13.13 11.23 3 423041 2226 42196065
Bacterial infection 13.13 11.23 196 422848 27683 42170608
Appendicitis 13.06 11.23 136 422908 20477 42177814
Hallucination, auditory 13.06 11.23 90 422954 14774 42183517
Colloid brain cyst 13.05 11.23 5 423039 9 42198282
Blood glucose decreased 13.04 11.23 206 422838 14013 42184278
Pneumonia cytomegaloviral 13.04 11.23 13 423031 4113 42194178
Splenic cyst 13.01 11.23 11 423033 131 42198160
Brain abscess 12.97 11.23 14 423030 4270 42194021
Fistula 12.95 11.23 38 423006 7874 42190417
Hand deformity 12.94 11.23 11 423033 3757 42194534
Neoplasm progression 12.94 11.23 206 422838 28794 42169497
Bile duct cancer 12.87 11.23 24 423020 669 42197622
Hypertensive nephropathy 12.87 11.23 20 423024 479 42197812
Mean platelet volume increased 12.84 11.23 23 423021 621 42197670
Tumour lysis syndrome 12.77 11.23 150 422894 22081 42176210
Periodontal disease 12.71 11.23 27 423017 829 42197462
Device use error 12.71 11.23 8 423036 3189 42195102
Superficial spreading melanoma stage I 12.71 11.23 7 423037 38 42198253
Dermatitis infected 12.68 11.23 13 423031 201 42198090
Haematemesis 12.67 11.23 391 422653 29808 42168483
Anal abscess 12.63 11.23 38 423006 7812 42190479
Peritoneal dialysis complication 12.63 11.23 45 422999 1882 42196409
Rheumatoid nodule 12.61 11.23 7 423037 2988 42195303
Prostate cancer recurrent 12.58 11.23 31 423013 1052 42197239
Systemic mycosis 12.58 11.23 4 423040 2383 42195908
Pneumocystis jirovecii pneumonia 12.57 11.23 175 422869 25006 42173285
Inguinal hernia, obstructive 12.51 11.23 6 423038 23 42198268
Anaemia Heinz body 12.51 11.23 6 423038 23 42198268
Blood aldosterone increased 12.51 11.23 6 423038 23 42198268
Hyperhidrosis 12.48 11.23 753 422291 89759 42108532
Hypoglycaemia neonatal 12.46 11.23 3 423041 2147 42196144
Gingival pain 12.40 11.23 134 422910 8360 42189931
Drug dispensed to wrong patient 12.34 11.23 20 423024 497 42197794
Epilepsy 12.32 11.23 184 422860 25987 42172304
Electrocardiogram T wave amplitude decreased 12.30 11.23 17 423027 365 42197926
Vertigo positional 12.29 11.23 29 423015 957 42197334
Aphthous ulcer 12.29 11.23 25 423019 5876 42192415
Hepatic failure 12.29 11.23 286 422758 37814 42160477
Renal cyst 12.26 11.23 153 422891 9886 42188405
Protein urine present 12.24 11.23 99 422945 5702 42192589
Herpes zoster 12.21 11.23 293 422751 38584 42159707
Tricuspid valve incompetence 12.16 11.23 166 422878 10947 42187344
Venous oxygen saturation decreased 12.15 11.23 7 423037 42 42198249
Flour sensitivity 12.13 11.23 6 423038 25 42198266
Sex hormone binding globulin increased 12.11 11.23 5 423039 12 42198279
Device breakage 12.11 11.23 11 423033 3638 42194653
Left ventricular enlargement 12.08 11.23 26 423018 806 42197485
Prerenal failure 12.03 11.23 52 422992 2381 42195910
Pain in extremity 12.02 11.23 1688 421356 148916 42049375
Gingivitis 12.01 11.23 74 422970 3899 42194392
Cerebral toxoplasmosis 12.01 11.23 3 423041 2095 42196196
Respiratory symptom 11.99 11.23 63 422981 11043 42187248
Erysipelas 11.98 11.23 105 422939 6191 42192100
Drug screen positive 11.96 11.23 14 423030 4117 42194174
Renal artery thrombosis 11.91 11.23 16 423028 334 42197957
Histology abnormal 11.91 11.23 16 423028 334 42197957
Toxic skin eruption 11.88 11.23 197 422847 13533 42184758
Noninfective gingivitis 11.87 11.23 19 423025 467 42197824
Salivary hypersecretion 11.86 11.23 62 422982 10881 42187410
Urticaria 11.85 11.23 607 422437 73429 42124862
Illness 11.83 11.23 175 422869 24755 42173536
Type 2 diabetes mellitus 11.83 11.23 253 422791 18218 42180073
Affective disorder 11.78 11.23 26 423018 5934 42192357
Subdural haematoma 11.77 11.23 307 422737 22831 42175460
Epstein-Barr viraemia 11.77 11.23 4 423040 2285 42196006
Mean arterial pressure decreased 11.76 11.23 13 423031 220 42198071
Bronchial hyperreactivity 11.76 11.23 44 423000 1885 42196406
Blood pressure orthostatic 11.74 11.23 8 423036 67 42198224
Hepatitis B reactivation 11.73 11.23 17 423027 4561 42193730
Arterial stenosis 11.72 11.23 32 423012 1157 42197134
Osteoma 11.68 11.23 9 423035 93 42198198
Electrocardiogram ST segment depression 11.68 11.23 56 422988 2681 42195610
Nocardiosis 11.67 11.23 21 423023 5169 42193122
Large intestine polyp 11.66 11.23 142 422902 9123 42189168
Cardiovascular disorder 11.65 11.23 192 422852 13173 42185118
Retinal vascular thrombosis 11.65 11.23 8 423036 68 42198223
Ventricular tachycardia 11.60 11.23 220 422824 29940 42168351
Product storage error 11.58 11.23 64 422980 11076 42187215
Arrhythmia 11.54 11.23 500 422544 39817 42158474
Polypectomy 11.54 11.23 22 423022 624 42197667
Ventricular hyperkinesia 11.53 11.23 13 423031 225 42198066
Prohormone brain natriuretic peptide increased 11.52 11.23 9 423035 95 42198196
Respiratory alkalosis 11.52 11.23 50 422994 2294 42195997
Acetabulum fracture 11.49 11.23 18 423026 434 42197857
Hypogammaglobulinaemia 11.46 11.23 70 422974 11821 42186470
Phaeochromocytoma 11.46 11.23 14 423030 265 42198026
Henoch-Schonlein purpura 11.45 11.23 47 422997 2103 42196188
Atrioventricular block second degree 11.44 11.23 76 422968 4111 42194180
Affect lability 11.39 11.23 14 423030 4030 42194261
Left atrial enlargement 11.37 11.23 29 423015 1006 42197285
Clostridial infection 11.36 11.23 13 423031 3861 42194430
Lymphomatoid papulosis 11.36 11.23 13 423031 229 42198062
Aortic valve incompetence 11.34 11.23 107 422937 6441 42191850
Antidepressant drug level below therapeutic 11.33 11.23 5 423039 15 42198276
Tooth dislocation 11.33 11.23 5 423039 15 42198276
Floppy iris syndrome 11.32 11.23 15 423029 309 42197982
Type IV hypersensitivity reaction 11.31 11.23 5 423039 2432 42195859
Blood aldosterone decreased 11.30 11.23 4 423040 5 42198286
Circulatory collapse 11.28 11.23 311 422733 23325 42174966
Hypertensive cardiomyopathy 11.26 11.23 11 423033 160 42198131
Blood creatinine abnormal 11.24 11.23 61 422983 3068 42195223

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3093.54 9.81 6064 818823 236317 109528095
Hypotension 1785.81 9.81 8185 816702 515664 109248748
Hand deformity 1328.49 9.81 74 824813 218432 109545980
Acute kidney injury 1324.67 9.81 8686 816201 626744 109137668
Intentional overdose 1312.96 9.81 2992 821895 129509 109634903
Pemphigus 1294.29 9.81 76 824811 214494 109549918
Synovitis 1271.06 9.81 250 824637 273842 109490570
Anti-cyclic citrullinated peptide antibody positive 1249.96 9.81 21 824866 181963 109582449
Distributive shock 1171.01 9.81 660 824227 5244 109759168
Shock 1163.17 9.81 1701 823186 51887 109712525
Maternal exposure during pregnancy 1149.71 9.81 248 824639 254635 109509777
Pericarditis 1108.54 9.81 158 824729 218956 109545456
Glossodynia 1095.75 9.81 172 824715 221832 109542580
Duodenal ulcer perforation 1086.96 9.81 58 824829 177642 109586770
Systemic lupus erythematosus 1069.66 9.81 287 824600 254051 109510361
Folliculitis 1060.14 9.81 44 824843 167609 109596803
Helicobacter infection 1056.84 9.81 78 824809 181799 109582613
Gingival hypertrophy 1013.29 9.81 540 824347 3791 109760621
Drug ineffective 982.58 9.81 6985 817902 1513555 108250857
Bradycardia 940.29 9.81 2923 821964 152594 109611818
Infusion related reaction 928.74 9.81 884 824003 380278 109384134
Treatment failure 884.01 9.81 483 824404 276751 109487661
Muscle injury 873.69 9.81 42 824845 140765 109623647
Wound 872.95 9.81 328 824559 234109 109530303
Rheumatic fever 834.08 9.81 16 824871 122563 109641849
Off label use 832.57 9.81 7183 817704 1493002 108271410
Drug intolerance 832.37 9.81 1087 823800 405425 109358987
Non-cardiogenic pulmonary oedema 819.83 9.81 365 824522 1619 109762793
Arthropathy 815.54 9.81 574 824313 286948 109477464
Irritable bowel syndrome 810.78 9.81 127 824760 164088 109600324
C-reactive protein abnormal 800.49 9.81 40 824847 129655 109634757
Contraindicated product administered 777.82 9.81 442 824445 247825 109516587
Toxicity to various agents 755.25 9.81 6144 818743 474411 109290001
Fibromyalgia 753.04 9.81 175 824712 170734 109593678
Psoriatic arthropathy 732.98 9.81 275 824612 196486 109567926
Vasoplegia syndrome 719.60 9.81 469 824418 4970 109759442
Impaired healing 719.42 9.81 283 824604 196434 109567978
Sleep disorder due to general medical condition, insomnia type 706.14 9.81 17 824870 105626 109658786
Blood pressure increased 690.30 9.81 3772 821115 254601 109509811
Hepatic enzyme increased 680.68 9.81 835 824052 320057 109444355
Facet joint syndrome 678.53 9.81 8 824879 96820 109667592
Therapeutic product effect decreased 665.21 9.81 509 824378 243807 109520605
Alopecia 629.80 9.81 1096 823791 363657 109400755
Lactic acidosis 624.54 9.81 1812 823075 90999 109673413
Hyponatraemia 612.18 9.81 3223 821664 214430 109549982
Rheumatoid factor positive 593.55 9.81 128 824759 131512 109632900
Lip dry 583.96 9.81 42 824845 100041 109664371
Fall 565.11 9.81 6930 817957 596552 109167860
Metabolic acidosis 562.69 9.81 1831 823056 97913 109666499
Cerebrovascular accident 560.51 9.81 2757 822130 178527 109585885
Breast cancer stage III 556.81 9.81 6 824881 79111 109685301
Renal impairment 554.49 9.81 2826 822061 185619 109578793
Swollen joint count increased 549.64 9.81 16 824871 83645 109680767
Ill-defined disorder 547.15 9.81 242 824645 156611 109607801
Orthostatic hypotension 545.31 9.81 1393 823494 64856 109699556
Bursitis 532.20 9.81 154 824733 129764 109634648
Hypersensitivity 527.29 9.81 1419 823468 402579 109361833
Exposure during pregnancy 513.01 9.81 306 824581 167118 109597294
Oedema peripheral 510.81 9.81 4193 820694 324467 109439945
Hyperkalaemia 506.25 9.81 2182 822705 133614 109630798
Blood pressure inadequately controlled 504.54 9.81 434 824453 7199 109757213
Joint range of motion decreased 485.29 9.81 152 824735 121680 109642732
Stomatitis 451.90 9.81 828 824059 269414 109494998
Lower respiratory tract infection 445.89 9.81 702 824185 242404 109522008
Type 2 diabetes mellitus 444.32 9.81 400 824487 176832 109587580
Discomfort 435.09 9.81 578 824309 214129 109550283
Angioedema 428.29 9.81 1660 823227 96840 109667572
Peripheral venous disease 426.79 9.81 60 824827 84057 109680355
Live birth 414.63 9.81 26 824861 69458 109694954
Swelling 411.32 9.81 1297 823590 349744 109414668
Deep vein thrombosis postoperative 406.35 9.81 7 824880 59284 109705128
Blood creatinine increased 404.54 9.81 2541 822346 180348 109584064
Syncope 398.19 9.81 2732 822155 199804 109564608
Hypokalaemia 398.05 9.81 2526 822361 179922 109584490
Liver injury 383.61 9.81 334 824553 150079 109614333
Infection 377.74 9.81 1407 823480 360793 109403619
Grip strength decreased 375.89 9.81 71 824816 80103 109684309
Overdose 374.52 9.81 3004 821883 230790 109533622
Injury 370.68 9.81 466 824421 176799 109587613
Wound infection 369.02 9.81 129 824758 96336 109668076
Hypertensive crisis 363.93 9.81 653 824234 23719 109740693
Product use issue 363.44 9.81 1154 823733 310541 109453871
Suspected suicide 359.90 9.81 503 824384 14696 109749716
Product use in unapproved indication 353.63 9.81 1926 822961 445451 109318961
Rheumatoid arthritis 350.21 9.81 1108 823779 298505 109465907
Abdominal discomfort 346.87 9.81 1633 823254 392225 109372187
Sinusitis 337.85 9.81 1110 823777 295578 109468834
Suicide attempt 334.92 9.81 1594 823293 101800 109662612
Renal failure 317.20 9.81 2825 822062 223749 109540663
Rhabdomyolysis 316.64 9.81 1751 823136 118650 109645762
Blister 315.35 9.81 774 824113 226602 109537810
Cerebral infarction 311.79 9.81 973 823914 50865 109713547
Blood cholesterol increased 311.64 9.81 563 824324 184222 109580190
Intentional product use issue 306.69 9.81 893 823994 247013 109517399
Blepharospasm 306.13 9.81 28 824859 54823 109709589
Cardiac failure congestive 303.36 9.81 2048 822839 148952 109615460
Drug abuse 303.27 9.81 536 824351 176875 109587537
Pregnancy 302.05 9.81 20 824867 51047 109713365
Hypoglycaemia 301.65 9.81 1683 823204 114421 109649991
Dislocation of vertebra 300.29 9.81 5 824882 43716 109720696
Myocardial infarction 299.94 9.81 2454 822433 189629 109574783
Musculoskeletal stiffness 299.56 9.81 1075 823812 278747 109485665
Angina pectoris 298.31 9.81 1083 823804 61212 109703200
Myelosuppression 295.22 9.81 168 824719 94172 109670240
BRASH syndrome 290.41 9.81 233 824654 3490 109760922
Autoimmune disorder 288.45 9.81 67 824820 65416 109698996
Adjustment disorder with depressed mood 286.04 9.81 9 824878 43874 109720538
Drug interaction 282.86 9.81 5271 819616 494912 109269500
Obesity 281.46 9.81 258 824629 113093 109651319
Night sweats 269.00 9.81 363 824524 133620 109630792
Pulmonary oedema 266.07 9.81 1466 823421 99193 109665219
X-ray abnormal 263.31 9.81 4 824883 38113 109726299
Atrial fibrillation 260.24 9.81 2739 822148 226903 109537509
Condition aggravated 259.83 9.81 3887 821000 730949 109033463
Gastrointestinal disorder 251.38 9.81 941 823946 241011 109523401
Onychomadesis 250.37 9.81 25 824862 45638 109718774
Inflammation 249.36 9.81 682 824205 192556 109571856
Therapeutic product effect incomplete 248.77 9.81 846 824041 222959 109541453
Coronary artery disease 248.17 9.81 1127 823760 70563 109693849
Osteoarthritis 245.16 9.81 632 824255 181991 109582421
Prescribed overdose 240.09 9.81 181 824706 87400 109677012
Sciatica 239.44 9.81 202 824685 92197 109672215
Lower limb fracture 238.90 9.81 132 824755 75216 109689196
Migraine 238.21 9.81 584 824303 171068 109593344
Urticaria 235.44 9.81 1403 823484 317454 109446958
Depressed level of consciousness 229.79 9.81 1530 823357 110748 109653664
Nail disorder 224.13 9.81 76 824811 57859 109706553
Coeliac disease 223.36 9.81 29 824858 43158 109721254
Chronic kidney disease 222.03 9.81 1141 823746 75150 109689262
Lupus vulgaris 220.67 9.81 7 824880 33876 109730536
Cardiogenic shock 218.71 9.81 928 823959 56410 109708002
Injection site reaction 216.11 9.81 207 824680 88863 109675549
Gait inability 211.21 9.81 437 824450 135939 109628473
Weight increased 210.67 9.81 2056 822831 417588 109346824
Hyperglycaemia 206.93 9.81 1212 823675 83878 109680534
Creatinine renal clearance decreased 206.37 9.81 484 824403 21331 109743081
C-reactive protein 206.13 9.81 4 824883 30327 109734085
Acute myocardial infarction 199.67 9.81 1187 823700 82590 109681822
Road traffic accident 198.82 9.81 308 824579 107090 109657322
Sinus bradycardia 198.61 9.81 576 824311 28907 109735505
Proteinuria 195.22 9.81 700 824187 39318 109725094
Hypomagnesaemia 193.49 9.81 928 823959 59442 109704970
Bone erosion 187.97 9.81 56 824831 46315 109718097
Blood pressure systolic increased 187.08 9.81 1159 823728 81832 109682580
Lung disorder 185.83 9.81 702 824185 179345 109585067
Dizziness 184.22 9.81 6648 818239 691545 109072867
Sleep disorder 182.80 9.81 810 824077 197834 109566578
Palpitations 182.66 9.81 1904 822983 157308 109607104
Dyspnoea 181.91 9.81 10039 814848 1096833 108667579
Atrioventricular block complete 181.80 9.81 438 824449 19644 109744768
Retinitis 181.75 9.81 16 824871 32311 109732101
Balance disorder 181.25 9.81 1488 823399 115072 109649340
Finger deformity 179.14 9.81 19 824868 33073 109731339
Breast cancer stage II 177.05 9.81 6 824881 27369 109737043
Dehydration 176.36 9.81 2998 821889 276513 109487899
Arthralgia 172.99 9.81 4460 820427 775172 108989240
Nasopharyngitis 170.12 9.81 2001 822886 392360 109372052
Hip arthroplasty 169.51 9.81 103 824784 55710 109708702
Transient ischaemic attack 161.20 9.81 920 823967 63062 109701350
Swollen tongue 159.41 9.81 879 824008 59483 109704929
Blood pressure decreased 157.86 9.81 1429 823458 113662 109650750
Drug ineffective for unapproved indication 155.48 9.81 334 824553 102504 109661908
Mobility decreased 154.16 9.81 1086 823801 236336 109528076
Dry mouth 151.65 9.81 872 824015 199076 109565336
Product label confusion 150.19 9.81 4 824883 22673 109741739
Red blood cell sedimentation rate abnormal 149.80 9.81 8 824879 24501 109739911
Back injury 146.02 9.81 86 824801 47313 109717099
Hypoaesthesia 142.27 9.81 1577 823310 312646 109451766
Circulatory collapse 142.22 9.81 667 824220 42326 109722086
Sprue-like enteropathy 140.56 9.81 110 824777 1586 109762826
Foot deformity 139.67 9.81 95 824792 48385 109716027
Loss of consciousness 139.25 9.81 2147 822740 194159 109570253
Lip swelling 138.63 9.81 745 824142 49922 109714490
Anuria 138.24 9.81 448 824439 23893 109740519
Atrioventricular block first degree 137.18 9.81 318 824569 13907 109750505
Sedation complication 136.73 9.81 391 824496 19464 109744948
Diabetes mellitus inadequate control 135.28 9.81 509 824378 29266 109735146
Pain 134.84 9.81 5788 819099 949167 108815245
Neurologic neglect syndrome 134.84 9.81 246 824641 9052 109755360
Maternal exposure timing unspecified 134.53 9.81 5 824882 21008 109743404
Renin increased 134.35 9.81 62 824825 304 109764108
Blood creatine phosphokinase increased 133.68 9.81 969 823918 72108 109692304
Blood calcium decreased 133.50 9.81 576 824311 35269 109729143
Device expulsion 133.31 9.81 33 824854 30858 109733554
Drug resistance 133.30 9.81 134 824753 56240 109708172
Erectile dysfunction 133.24 9.81 371 824516 18185 109746227
Hemiplegia 130.92 9.81 421 824466 22361 109742051
Joint swelling 130.75 9.81 2420 822467 440425 109323987
Onychomycosis 128.82 9.81 63 824824 38468 109725944
Pyrexia 127.49 9.81 5441 819446 892824 108871588
Myalgia 127.32 9.81 2349 822538 220032 109544380
Dysarthria 126.55 9.81 1066 823821 83055 109681357
Musculoskeletal pain 125.34 9.81 824 824063 182199 109582213
Pemphigoid 125.10 9.81 377 824510 19330 109745082
Cardiac failure 123.25 9.81 2026 822861 185600 109578812
Rash 122.77 9.81 4943 819944 816021 108948391
Neutropenia 121.50 9.81 2013 822874 372607 109391805
Carotid artery thrombosis 121.23 9.81 240 824647 9398 109755014
Anti-cyclic citrullinated peptide antibody 120.52 9.81 7 824880 19957 109744455
Adverse event 119.69 9.81 413 824474 108396 109656016
Exostosis 119.63 9.81 100 824787 45856 109718556
Therapy non-responder 119.29 9.81 686 824201 156621 109607791
Interstitial lung disease 119.22 9.81 1575 823312 137759 109626653
Nasal oedema 117.51 9.81 195 824692 6644 109757768
Melaena 117.42 9.81 897 823990 67860 109696552
Hypertensive emergency 116.01 9.81 134 824753 3217 109761195
Ear infection 114.11 9.81 182 824705 62550 109701862
Nocturia 111.62 9.81 329 824558 16661 109747751
Knee arthroplasty 111.14 9.81 196 824691 64752 109699660
Glomerular filtration rate decreased 110.69 9.81 469 824418 28487 109735925
Cough 109.63 9.81 4346 820541 457295 109307117
Epilepsy 109.12 9.81 382 824505 99827 109664585
Hepatic function abnormal 107.69 9.81 1079 823808 88216 109676196
Abortion spontaneous 107.31 9.81 61 824826 34221 109730191
Carotid artery stenosis 106.23 9.81 222 824665 9041 109755371
Anaemia 106.03 9.81 5043 819844 542043 109222369
Cerebral haemorrhage 105.65 9.81 838 824049 64130 109700282
Gingival swelling 105.35 9.81 162 824725 5168 109759244
Hemiparesis 105.20 9.81 623 824264 43280 109721132
Blood urea increased 104.74 9.81 736 824151 54221 109710191
Hypercholesterolaemia 104.56 9.81 338 824549 90499 109673913
C-reactive protein increased 103.70 9.81 1081 823806 216838 109547574
Porphyria acute 103.69 9.81 10 824877 18770 109745642
Product monitoring error 103.61 9.81 215 824672 8712 109755700
Lupus-like syndrome 102.25 9.81 92 824795 40700 109723712
Normal newborn 101.34 9.81 20 824867 21876 109742536
Blood glucose increased 98.92 9.81 1462 823425 131034 109633378
Atrioventricular block 98.91 9.81 314 824573 16563 109747849
Personality disorder 98.50 9.81 263 824624 12574 109751838
Febrile neutropenia 96.90 9.81 1720 823167 315047 109449365
Dyspnoea exertional 96.52 9.81 1194 823693 102866 109661546
Oliguria 95.86 9.81 332 824555 18325 109746087
Product prescribing error 94.66 9.81 682 824205 50649 109713763
Hyperlipidaemia 93.29 9.81 520 824367 35328 109729084
Adjustment disorder 92.99 9.81 231 824656 10564 109753848
Angina unstable 92.92 9.81 302 824585 16130 109748282
Liver function test increased 92.80 9.81 343 824544 88205 109676207
Renal artery stenosis 92.25 9.81 126 824761 3600 109760812
Eating disorder 91.50 9.81 464 824423 30394 109734018
Pulmonary fibrosis 91.49 9.81 420 824467 101622 109662790
Disability 91.46 9.81 56 824831 30167 109734245
Immunodeficiency 91.05 9.81 93 824794 38745 109725667
Laryngitis 90.17 9.81 110 824777 42301 109722111
Memory impairment 89.25 9.81 988 823899 195956 109568456
Drug dependence 88.29 9.81 148 824739 49872 109714540
Hypocalcaemia 88.29 9.81 809 824078 64557 109699855
Hyperdynamic left ventricle 88.14 9.81 55 824832 537 109763875
Renal disorder 87.58 9.81 651 824236 48828 109715584
Aphasia 87.34 9.81 745 824142 58252 109706160
Osteoporosis 87.19 9.81 344 824543 86808 109677604
Glycosylated haemoglobin increased 86.77 9.81 378 824509 23241 109741171
Injection site erythema 86.61 9.81 384 824503 93792 109670620
Tubulointerstitial nephritis 86.52 9.81 697 824190 53587 109710825
Lethargy 86.05 9.81 1072 823815 92504 109671908
Contusion 85.80 9.81 1224 823663 232137 109532275
Left ventricular hypertrophy 85.62 9.81 255 824632 12989 109751423
Aortic dissection 85.22 9.81 141 824746 4792 109759620
Infusion site reaction 84.29 9.81 15 824872 17667 109746745
Taste disorder 84.13 9.81 231 824656 65156 109699256
Haemodynamic instability 83.86 9.81 366 824521 22522 109741890
Anti-neutrophil cytoplasmic antibody positive vasculitis 83.26 9.81 147 824740 5270 109759142
Subacute cutaneous lupus erythematosus 82.61 9.81 140 824747 4854 109759558
Arterial occlusive disease 81.80 9.81 276 824611 15032 109749380
Gangrene 81.54 9.81 288 824599 16053 109748359
Heart rate decreased 80.86 9.81 959 823928 81797 109682615
Nephrotic syndrome 80.75 9.81 257 824630 13574 109750838
Foetal death 80.09 9.81 12 824875 16033 109748379
Haematemesis 80.06 9.81 732 824155 58376 109706036
Swelling face 79.97 9.81 1046 823841 91275 109673137
Product quality issue 79.32 9.81 302 824585 76997 109687415
Renal cell carcinoma 78.92 9.81 174 824713 7356 109757056
Blood potassium decreased 78.88 9.81 681 824206 53433 109710979
Female genital tract fistula 78.77 9.81 14 824873 16505 109747907
Dyspepsia 78.42 9.81 979 823908 189986 109574426
Lacunar infarction 78.42 9.81 156 824731 6130 109758282
Drug use disorder 76.66 9.81 20 824867 18054 109746358
Altered state of consciousness 76.21 9.81 710 824177 56916 109707496
Gingival bleeding 74.80 9.81 320 824567 19519 109744893
Palmar-plantar erythrodysaesthesia syndrome 74.45 9.81 543 824344 40482 109723930
Chronic obstructive pulmonary disease 74.00 9.81 1185 823702 107973 109656439
Breath sounds abnormal 73.93 9.81 380 824507 25024 109739388
Gastrointestinal haemorrhage 73.79 9.81 1685 823202 163833 109600579
Periodontitis 73.27 9.81 136 824751 5072 109759340
Adverse reaction 72.69 9.81 68 824819 29526 109734886
Chronic pigmented purpura 72.58 9.81 38 824849 256 109764156
Walking aid user 72.41 9.81 49 824838 25026 109739386
Affect lability 72.12 9.81 303 824584 18334 109746078
Cardiac arrest 71.94 9.81 1950 822937 194803 109569609
Coordination abnormal 71.78 9.81 375 824512 24853 109739559
Abdominal pain upper 71.49 9.81 2019 822868 347092 109417320
Pollakiuria 71.27 9.81 569 824318 43626 109720786
Injection site pain 70.88 9.81 918 823969 177004 109587408
Temperature regulation disorder 70.37 9.81 7 824880 12819 109751593
Cognitive disorder 69.83 9.81 977 823910 86534 109677878
Ischaemic stroke 69.71 9.81 537 824350 40726 109723686
Arrhythmia 69.63 9.81 810 824077 68765 109695647
Therapy partial responder 68.85 9.81 106 824781 36955 109727457
Subdural haematoma 68.76 9.81 487 824400 35967 109728445
Post transplant lymphoproliferative disorder 68.71 9.81 16 824871 15597 109748815
Ear pain 68.51 9.81 188 824699 53038 109711374
Haemoglobin decreased 68.48 9.81 2381 822506 246346 109518066
Haemodialysis 67.73 9.81 287 824600 17432 109746980
Hypertensive heart disease 67.16 9.81 122 824765 4474 109759938
Pathogen resistance 66.94 9.81 24 824863 17648 109746764
Blood lactic acid increased 66.59 9.81 264 824623 15557 109748855
Hepatic cirrhosis 65.71 9.81 270 824617 67356 109697056
Colitis ulcerative 65.51 9.81 325 824562 77038 109687374
Disease progression 65.42 9.81 1355 823532 242679 109521733
Immune reconstitution inflammatory syndrome 65.03 9.81 20 824867 16206 109748206
Joint stiffness 65.01 9.81 269 824618 66974 109697438
Constipation 64.81 9.81 3277 821610 354509 109409903
Vertigo 64.22 9.81 957 823930 85913 109678499
Congenital hiatus hernia 63.77 9.81 143 824744 6116 109758296
Drug tolerance decreased 63.37 9.81 67 824820 27473 109736939
Micturition urgency 63.36 9.81 299 824588 19021 109745391
Infective pulmonary exacerbation of cystic fibrosis 63.31 9.81 16 824871 14755 109749657
Sensory loss 63.17 9.81 322 824565 21135 109743277
Cytomegalovirus infection 63.06 9.81 202 824685 54242 109710170
Cytomegalovirus infection reactivation 62.78 9.81 29 824858 18304 109746108
Blood potassium increased 62.60 9.81 444 824443 32805 109731607
Haematotoxicity 62.50 9.81 40 824847 21042 109743370
Urinary retention 62.23 9.81 794 824093 68889 109695523
Hypervolaemia 62.23 9.81 603 824284 48857 109715555
Tongue oedema 62.19 9.81 168 824719 8088 109756324
Leukopenia 61.38 9.81 762 824125 148029 109616383
Harlequin syndrome 61.18 9.81 33 824854 238 109764174
Mitral valve incompetence 60.98 9.81 442 824445 32887 109731525
Nodal rhythm 60.70 9.81 99 824788 3324 109761088
Carotid arteriosclerosis 60.54 9.81 93 824794 2964 109761448
Faeces discoloured 60.27 9.81 447 824440 33501 109730911
Gastrointestinal tract mucosal pigmentation 59.95 9.81 60 824827 1217 109763195
Respiratory failure 59.69 9.81 2063 822824 213269 109551143
Myocardial depression 59.64 9.81 47 824840 685 109763727
Multiple-drug resistance 59.37 9.81 13 824874 13222 109751190
Asthenia 59.18 9.81 5936 818951 683063 109081349
Bundle branch block right 59.09 9.81 214 824673 12077 109752335
Chest pain 58.77 9.81 3400 821487 372975 109391437
Product substitution issue 58.34 9.81 332 824555 22729 109741683
Inappropriate antidiuretic hormone secretion 58.00 9.81 442 824445 33409 109731003
Gout 58.00 9.81 469 824418 36097 109728315
Electrolyte imbalance 57.69 9.81 473 824414 36555 109727857
Paraesthesia 57.66 9.81 1595 823292 274926 109489486
Diabetic nephropathy 57.58 9.81 98 824789 3410 109761002
Primary hyperaldosteronism 57.43 9.81 32 824855 248 109764164
Thalamus haemorrhage 57.29 9.81 72 824815 1892 109762520
Hypothermia 57.19 9.81 364 824523 25938 109738474
Protein urine present 56.96 9.81 202 824685 11282 109753130
Cardiomegaly 56.61 9.81 392 824495 28738 109735674
Adverse drug reaction 56.36 9.81 509 824378 105050 109659362
Liver disorder 56.25 9.81 735 824152 141508 109622904
Hepatocellular carcinoma 56.24 9.81 182 824705 9698 109754714
Haemorrhage subcutaneous 55.82 9.81 126 824761 5413 109758999
Benign prostatic hyperplasia 55.34 9.81 276 824611 17958 109746454
Body temperature increased 55.34 9.81 215 824672 54498 109709914
Therapeutic response decreased 54.77 9.81 458 824429 96041 109668371
Peripheral arterial occlusive disease 54.70 9.81 173 824714 9107 109755305
Upper respiratory tract infection 54.38 9.81 672 824215 130656 109633756
Red blood cell sedimentation rate increased 54.36 9.81 351 824536 77951 109686461
Myocardial ischaemia 54.19 9.81 363 824524 26321 109738091
Gastric ulcer haemorrhage 53.94 9.81 182 824705 9912 109754500
Prescribed underdose 53.92 9.81 276 824611 64898 109699514
Tenosynovitis 53.86 9.81 27 824860 16256 109748156
Motor dysfunction 53.83 9.81 339 824548 24067 109740345
Diabetes mellitus 53.47 9.81 1040 823847 98341 109666071
Acute graft versus host disease 53.23 9.81 15 824872 12866 109751546
Acute respiratory distress syndrome 53.08 9.81 619 824268 52579 109711833
Intentional self-injury 52.95 9.81 126 824761 37303 109727109
Hypoxia 52.69 9.81 1302 823585 128213 109636199
Chronic sinusitis 52.34 9.81 66 824821 25018 109739394
Acute coronary syndrome 52.21 9.81 323 824564 22789 109741623
Hyperuricaemia 52.20 9.81 231 824656 14300 109750112
Generalised oedema 52.10 9.81 400 824487 30304 109734108
Decreased appetite 52.08 9.81 4173 820714 471673 109292739
Cytokine release syndrome 52.00 9.81 309 824578 69997 109694415
Diastolic dysfunction 51.42 9.81 206 824681 12198 109752214
Gravitational oedema 51.31 9.81 67 824820 1831 109762581
Urine output decreased 50.84 9.81 287 824600 19589 109744823
Presyncope 50.64 9.81 573 824314 48314 109716098
Ulcer haemorrhage 49.63 9.81 57 824830 22514 109741898
Pleural effusion 49.35 9.81 1703 823184 176006 109588406
Vasodilatation 49.24 9.81 95 824792 3649 109760763
Hyperaldosteronism 48.99 9.81 40 824847 615 109763797
Proctitis 48.98 9.81 33 824854 16894 109747518
Pseudolymphoma 48.95 9.81 53 824834 1182 109763230
Linear IgA disease 48.95 9.81 104 824783 4285 109760127
Depression 48.70 9.81 1904 822983 315431 109448981
Sinus congestion 48.49 9.81 391 824496 30068 109734344
Dysphagia 48.34 9.81 1494 823393 152106 109612306
Hypoinsulinaemia 48.10 9.81 13 824874 3 109764409
Pulmonary renal syndrome 47.98 9.81 44 824843 797 109763615
Vaginal discharge 47.81 9.81 38 824849 17870 109746542
Chest discomfort 47.53 9.81 1663 823224 172185 109592227
Gamma-glutamyltransferase increased 47.52 9.81 681 824206 60628 109703784
Lung diffusion test abnormal 47.27 9.81 32 824855 363 109764049
Joint dislocation 46.87 9.81 117 824770 34073 109730339
Atrioventricular block second degree 46.84 9.81 151 824736 8030 109756382
Prostatic specific antigen increased 46.55 9.81 201 824686 12310 109752102
Gingival pain 46.22 9.81 236 824651 15500 109748912
Dysgeusia 45.66 9.81 755 824132 69230 109695182
Blood glucose decreased 45.57 9.81 376 824511 29112 109735300
Electrocardiogram abnormal 45.15 9.81 266 824621 18443 109745969
Bradyarrhythmia 45.07 9.81 108 824779 4826 109759586
Malaise 44.96 9.81 5695 819192 666124 109098288
Gingivitis 44.79 9.81 174 824713 10157 109754255
Glomerulonephritis rapidly progressive 44.73 9.81 68 824819 2147 109762265
Underdose 44.57 9.81 284 824603 63270 109701142
Metastatic renal cell carcinoma 44.35 9.81 72 824815 2408 109762004
Food allergy 44.27 9.81 50 824837 19898 109744514
Aplastic anaemia 44.26 9.81 322 824565 23986 109740426
Haematochezia 43.37 9.81 1149 823738 114375 109650037
Cardiac disorder 43.35 9.81 805 824082 75475 109688937
Renal function test abnormal 43.21 9.81 156 824731 8790 109755622
Ischaemic cardiomyopathy 42.42 9.81 144 824743 7867 109756545
Oedema 42.37 9.81 1944 822943 208032 109556380
Dialysis 42.34 9.81 271 824616 19348 109745064
Aspergillus infection 42.31 9.81 79 824808 25537 109738875
Retinopathy hypertensive 42.08 9.81 35 824852 553 109763859
Wrong technique in product usage process 42.05 9.81 432 824455 86916 109677496
Cataract 41.82 9.81 829 824058 78656 109685756
Supraventricular extrasystoles 41.77 9.81 144 824743 7929 109756483
Cutaneous vasculitis 41.74 9.81 197 824690 12532 109751880
Drug eruption 41.58 9.81 596 824291 53063 109711349
Multiple drug therapy 41.51 9.81 143 824744 7871 109756541
Joint destruction 41.22 9.81 15 824872 10928 109753484
General symptom 41.11 9.81 8 824879 8838 109755574
Urine albumin/creatinine ratio increased 41.06 9.81 46 824841 1067 109763345
Gastrooesophageal reflux disease 40.96 9.81 1025 823862 178951 109585461
Frequent bowel movements 40.89 9.81 338 824549 71052 109693360
Diabetic neuropathy 40.81 9.81 130 824757 6869 109757543
Device difficult to use 40.80 9.81 48 824839 18757 109745655
Peripheral coldness 40.57 9.81 257 824630 18283 109746129
Fibromuscular dysplasia 40.50 9.81 27 824860 298 109764114
Duodenal ulcer haemorrhage 40.41 9.81 142 824745 7895 109756517
Upper gastrointestinal haemorrhage 40.25 9.81 560 824327 49536 109714876
Haemophagocytic lymphohistiocytosis 40.22 9.81 112 824775 31447 109732965
Thrombocytopenia 40.04 9.81 2160 822727 346725 109417687
Blood lactic acid decreased 40.02 9.81 34 824853 554 109763858
Diarrhoea 39.82 9.81 9331 815556 1130174 108634238
Thirst 39.78 9.81 288 824599 21419 109742993
Drug tolerance 39.69 9.81 39 824848 16546 109747866
Injection site pruritus 39.67 9.81 222 824665 51036 109713376
Malignant melanoma in situ 39.59 9.81 84 824803 3458 109760954
Progressive multifocal leukoencephalopathy 39.44 9.81 79 824808 24877 109739535
Nephrosclerosis 39.35 9.81 61 824826 1960 109762452
Injection site warmth 39.32 9.81 43 824844 17362 109747050
Radiculopathy 39.19 9.81 52 824835 19284 109745128
Vision blurred 39.03 9.81 1249 823638 127773 109636639
Blood mercury abnormal 38.99 9.81 25 824862 257 109764155
Myopathy 38.97 9.81 319 824568 24641 109739771
Blood sodium decreased 38.73 9.81 447 824440 37872 109726540
5-hydroxyindolacetic acid in urine increased 38.70 9.81 22 824865 178 109764234
Lymphocele 38.58 9.81 58 824829 1813 109762599
Ischaemia 38.58 9.81 152 824735 8931 109755481
Caesarean section 38.58 9.81 28 824859 13789 109750623
Insomnia 38.36 9.81 2249 822638 358341 109406071
Bone marrow failure 38.30 9.81 263 824624 57585 109706827
Jaundice 38.26 9.81 638 824249 58598 109705814
Adenovirus infection 38.26 9.81 17 824870 10977 109753435
Schizophrenia 38.13 9.81 65 824822 21761 109742651
Sinus node dysfunction 38.11 9.81 151 824736 8896 109755516
Breast cancer stage I 38.10 9.81 5 824882 7382 109757030
Prerenal failure 37.97 9.81 95 824792 4364 109760048
Ageusia 37.96 9.81 264 824623 19381 109745031
Swollen joint count 37.95 9.81 9 824878 8665 109755747
Chromaturia 37.95 9.81 360 824527 29000 109735412
Acidosis 37.94 9.81 293 824594 22238 109742174
Hyperlactacidaemia 37.93 9.81 142 824745 8144 109756268
Nodule 37.84 9.81 121 824766 32510 109731902
Cardiovascular disorder 37.78 9.81 295 824592 22465 109741947
Forced vital capacity decreased 37.71 9.81 59 824828 1911 109762501
End stage renal disease 37.70 9.81 282 824605 21191 109743221
Injection site swelling 37.49 9.81 288 824599 61502 109702910
Drug level increased 37.36 9.81 531 824356 47188 109717224
Chronic graft versus host disease 37.29 9.81 12 824875 9445 109754967
Incorrect route of product administration 37.28 9.81 302 824585 63759 109700653
Maternal exposure before pregnancy 37.28 9.81 5 824882 7260 109757152
Diabetic retinopathy 36.95 9.81 82 824805 3482 109760930
Hyperthyroidism 36.93 9.81 357 824530 28904 109735508
Cardiac output increased 36.89 9.81 33 824854 578 109763834
Yellow skin 36.63 9.81 89 824798 4013 109760399
Overlap syndrome 36.61 9.81 11 824876 9048 109755364
Haemorrhage intracranial 36.35 9.81 353 824534 28616 109735796
Bundle branch block left 36.27 9.81 191 824696 12697 109751715
Pericardial effusion 36.13 9.81 614 824273 56603 109707809
Putamen haemorrhage 36.04 9.81 31 824856 514 109763898
Injection site bruising 35.98 9.81 229 824658 51034 109713378
Femoral neck fracture 35.89 9.81 187 824700 12380 109752032
Septic shock 35.89 9.81 897 823990 156631 109607781
Nephrogenic systemic fibrosis 35.85 9.81 106 824781 5377 109759035
Arteriosclerosis 35.73 9.81 311 824576 24456 109739956
Diffuse large B-cell lymphoma recurrent 35.73 9.81 3 824884 6296 109758116
Sinus arrest 35.73 9.81 90 824797 4152 109760260
Hepatic neoplasm 35.71 9.81 85 824802 3782 109760630
Brain stem infarction 35.53 9.81 60 824827 2074 109762338
Skin haemorrhage 35.43 9.81 311 824576 24516 109739896
Bronchopulmonary aspergillosis 35.14 9.81 110 824777 29753 109734659
Hypovolaemic shock 34.97 9.81 207 824680 14376 109750036
Pulmonary vasculitis 34.92 9.81 4 824883 6556 109757856
Pulse abnormal 34.91 9.81 88 824799 4061 109760351
Mental status changes 34.87 9.81 778 824109 75344 109689068
Coronary artery stenosis 34.76 9.81 198 824689 13560 109750852
Acute myeloid leukaemia 34.67 9.81 156 824731 37954 109726458
Head injury 34.61 9.81 481 824406 42536 109721876
Hepatitis 34.26 9.81 469 824418 89585 109674827
Hepatotoxicity 34.15 9.81 305 824582 63095 109701317
Intestinal ischaemia 34.00 9.81 222 824665 15957 109748455
Unintentional medical device removal 34.00 9.81 12 824875 8911 109755501
Acute hepatic failure 33.95 9.81 148 824739 36320 109728092
Procedural pain 33.92 9.81 143 824744 35422 109728990
Peripheral artery stenosis 33.84 9.81 46 824841 1308 109763104
Blood pressure abnormal 33.62 9.81 284 824603 22140 109742272
Cerebellar haemorrhage 33.62 9.81 75 824812 3196 109761216
Blood aldosterone increased 33.57 9.81 21 824866 206 109764206
Skin exfoliation 33.54 9.81 874 824013 86777 109677635
Hepatojugular reflux 33.53 9.81 34 824853 701 109763711
Vitamin B1 decreased 33.27 9.81 38 824849 901 109763511
Neovascularisation 33.22 9.81 52 824835 1685 109762727
Premature delivery 33.19 9.81 117 824770 30515 109733897
Hypertensive encephalopathy 33.13 9.81 43 824844 1168 109763244
Psychotic disorder 33.02 9.81 233 824654 50704 109713708
Hypercalcaemia 32.94 9.81 510 824377 46147 109718265
Eosinophilia 32.78 9.81 611 824276 57325 109707087
Large intestine polyp 32.74 9.81 209 824678 14908 109749504
Mydriasis 32.63 9.81 73 824814 22084 109742328
Aortic stenosis 32.38 9.81 187 824700 12872 109751540
Hypovolaemia 32.23 9.81 274 824613 21400 109743012
Ventricular extrasystoles 31.99 9.81 283 824604 22358 109742054
Kidney transplant rejection 31.94 9.81 175 824712 11812 109752600
Carcinoid tumour 31.77 9.81 30 824857 565 109763847
Cardiac failure high output 31.70 9.81 28 824859 482 109763930
Disorientation 31.65 9.81 720 824167 69951 109694461
Hypocholesterolaemia 31.60 9.81 5 824882 6416 109757996
Labelled drug-drug interaction medication error 31.51 9.81 346 824541 28956 109735456
Pancreatitis acute 31.49 9.81 628 824259 59646 109704766
Peripheral artery occlusion 31.44 9.81 68 824819 2837 109761575
Substance abuse 31.37 9.81 28 824859 12435 109751977
Accelerated hypertension 31.24 9.81 34 824853 763 109763649
Hypophagia 31.17 9.81 559 824328 52067 109712345
Diverticulum intestinal haemorrhagic 31.07 9.81 92 824795 4671 109759741
Graft versus host disease 31.06 9.81 58 824829 18748 109745664
Leukocytosis 30.91 9.81 569 824318 53259 109711153
Ventricular hypertrophy 30.82 9.81 119 824768 6926 109757486
Renal transplant 30.80 9.81 72 824815 3166 109761246
Duodenal ulcer 30.79 9.81 250 824637 19264 109745148
Intestinal villi atrophy 30.63 9.81 29 824858 548 109763864
Colon cancer 30.62 9.81 219 824668 16224 109748188
Mean arterial pressure decreased 30.60 9.81 27 824860 464 109763948
Muscle necrosis 30.56 9.81 51 824836 1746 109762666
Extrasystoles 30.46 9.81 133 824754 8185 109756227
Haematuria 30.41 9.81 823 824064 82182 109682230
Mucormycosis 30.38 9.81 21 824866 10607 109753805
Dyspnoea at rest 30.22 9.81 133 824754 8213 109756199
Uterine perforation 30.12 9.81 7 824880 6833 109757579
Blood urea abnormal 29.89 9.81 52 824835 1842 109762570
Dyslalia 29.80 9.81 44 824843 1353 109763059
Device leakage 29.71 9.81 46 824841 16002 109748410
Venoocclusive liver disease 29.71 9.81 42 824845 15165 109749247
Purpura 29.54 9.81 295 824592 24093 109740319
Cardiac failure acute 29.53 9.81 292 824595 23786 109740626
Drug dose omission by device 29.46 9.81 39 824848 14477 109749935
Clear cell renal cell carcinoma 29.24 9.81 64 824823 2692 109761720
Glucose tolerance impaired 29.22 9.81 148 824739 9689 109754723
Low density lipoprotein decreased 29.21 9.81 44 824843 1378 109763034
Neck pain 29.17 9.81 697 824190 122433 109641979
Cardiac dysfunction 28.78 9.81 107 824780 6116 109758296
Coma scale abnormal 28.66 9.81 146 824741 9580 109754832
Interstitial granulomatous dermatitis 28.64 9.81 21 824866 273 109764139
Nephrogenic anaemia 28.53 9.81 87 824800 4490 109759922
Mycotic allergy 28.49 9.81 5 824882 5949 109758463
Cardiac myxoma 28.48 9.81 19 824868 210 109764202
Pyelonephritis acute 28.48 9.81 118 824769 7095 109757317
Sickle cell anaemia with crisis 28.45 9.81 18 824869 9527 109754885
Rales 28.41 9.81 296 824591 24443 109739969
Hypoperfusion 28.39 9.81 69 824818 3112 109761300
Essential hypertension 28.38 9.81 125 824762 7722 109756690
Immune-mediated myositis 28.31 9.81 106 824781 6080 109758332
Macular degeneration 28.25 9.81 76 824811 21583 109742829
Epstein-Barr virus infection 28.20 9.81 61 824826 18677 109745735
Coronary artery occlusion 28.18 9.81 208 824679 15564 109748848
Device issue 28.14 9.81 147 824740 34388 109730024
Skin tightness 28.07 9.81 99 824788 5514 109758898
Azotaemia 28.07 9.81 149 824738 9936 109754476
Dizziness postural 28.04 9.81 196 824691 14413 109749999
Ocular icterus 27.93 9.81 104 824783 5949 109758463
Dementia 27.90 9.81 360 824527 31313 109733099
Hepatic enzyme 27.86 9.81 3 824884 5160 109759252
Drug-induced liver injury 27.80 9.81 682 824205 119385 109645027
Premature labour 27.75 9.81 17 824870 9155 109755257
Ovarian cyst 27.68 9.81 38 824849 13892 109750520
Prescription drug used without a prescription 27.54 9.81 97 824790 5399 109759013
Sneezing 27.53 9.81 362 824525 31622 109732790
Plasma cell myeloma 27.50 9.81 639 824248 62297 109702115
Dysuria 27.40 9.81 615 824272 59616 109704796
Aggression 27.22 9.81 296 824591 58914 109705498
Potentiating drug interaction 27.11 9.81 164 824723 11479 109752933
General physical health deterioration 27.03 9.81 2768 822119 422527 109341885
Hypersensitivity vasculitis 27.01 9.81 113 824774 6824 109757588
Glomerulonephritis acute 26.99 9.81 21 824866 300 109764112
Breast cancer female 26.86 9.81 32 824855 12436 109751976
Dilatation ventricular 26.85 9.81 79 824808 3996 109760416
Graft versus host disease in skin 26.83 9.81 14 824873 8240 109756172
Loss of personal independence in daily activities 26.65 9.81 884 824003 149136 109615276
Lymphocyte stimulation test positive 26.58 9.81 36 824851 1020 109763392
Respiratory tract infection 26.50 9.81 711 824176 70906 109693506
Amnesia 26.28 9.81 592 824295 104816 109659596
Zoonotic bacterial infection 26.20 9.81 13 824874 77 109764335
Electrocardiogram Q wave abnormal 26.18 9.81 30 824857 714 109763698
Hypertonic bladder 26.07 9.81 93 824794 5209 109759203
Multiple sclerosis relapse 26.06 9.81 244 824643 49996 109714416
Cerebral ischaemia 26.00 9.81 167 824720 11937 109752475
Status epilepticus 25.94 9.81 134 824753 31437 109732975
Flatulence 25.81 9.81 539 824348 51610 109712802
Red blood cell sedimentation rate 25.79 9.81 4 824883 5210 109759202
Blood parathyroid hormone increased 25.78 9.81 80 824807 4168 109760244
Heavy menstrual bleeding 25.70 9.81 52 824835 16313 109748099
Tachypnoea 25.70 9.81 425 824462 38970 109725442
No adverse event 25.48 9.81 392 824495 73447 109690965
Sinoatrial block 25.48 9.81 42 824845 1423 109762989
Pericarditis uraemic 25.28 9.81 8 824879 9 109764403
Tricuspid valve incompetence 25.26 9.81 281 824606 23592 109740820
Systemic infection 25.26 9.81 142 824745 9677 109754735
Injection site urticaria 25.12 9.81 57 824830 17158 109747254
Drug hypersensitivity 25.09 9.81 2984 821903 451106 109313306
Hypergastrinaemia 25.08 9.81 21 824866 335 109764077
Hyperammonaemic encephalopathy 25.07 9.81 5 824882 5429 109758983
Renal injury 24.96 9.81 231 824656 18482 109745930
Glomerular filtration rate abnormal 24.90 9.81 55 824832 2328 109762084
Intraventricular haemorrhage 24.90 9.81 94 824793 5413 109758999
Human herpesvirus 6 infection 24.82 9.81 9 824878 6572 109757840
Bladder irritation 24.70 9.81 22 824865 383 109764029
Gastrointestinal toxicity 24.68 9.81 28 824859 11120 109753292
Intercepted product preparation error 24.61 9.81 10 824877 6810 109757602
Urine protein/creatinine ratio increased 24.58 9.81 43 824844 1530 109762882
Labile hypertension 24.26 9.81 26 824861 573 109763839
Colitis microscopic 24.14 9.81 177 824710 13217 109751195
Aortic aneurysm 24.02 9.81 141 824746 9763 109754649
Bundle branch block 24.02 9.81 46 824841 1757 109762655
Periorbital oedema 24.01 9.81 144 824743 10048 109754364
Blood aldosterone decreased 24.01 9.81 8 824879 12 109764400
Anaphylactic reaction 23.88 9.81 659 824228 113641 109650771
Blood pressure systolic decreased 23.87 9.81 177 824710 13264 109751148
Pancytopenia 23.80 9.81 1299 823588 208314 109556098
Polypectomy 23.76 9.81 42 824845 1507 109762905
Feeling abnormal 23.66 9.81 1608 823279 179103 109585309
Dermatitis atopic 23.64 9.81 293 824594 25248 109739164
Polymyositis 23.60 9.81 71 824816 3637 109760775
Medication error 23.57 9.81 986 823901 104380 109660032
Embolic stroke 23.53 9.81 128 824759 8615 109755797
Body tinea 23.45 9.81 50 824837 2065 109762347
Device use error 23.38 9.81 20 824867 9069 109755343
Conduction disorder 23.36 9.81 75 824812 3980 109760432
Cryopyrin associated periodic syndrome 23.35 9.81 26 824861 599 109763813
Epistaxis 23.34 9.81 1193 823694 129179 109635233
Drug withdrawal syndrome 23.26 9.81 177 824710 37877 109726535
Dystonia 23.25 9.81 106 824781 25699 109738713
Eye swelling 23.23 9.81 361 824526 32687 109731725
Erysipelas 23.21 9.81 173 824714 12985 109751427
Gingival disorder 23.19 9.81 76 824811 4077 109760335
Unintended pregnancy 23.09 9.81 4 824883 4804 109759608
Stenosis 23.08 9.81 66 824821 3285 109761127
Needle fatigue 23.02 9.81 37 824850 1227 109763185
Respiratory disorder 22.95 9.81 384 824503 70998 109693414
Electrocardiogram P wave abnormal 22.87 9.81 21 824866 381 109764031
Allergic reaction to excipient 22.85 9.81 29 824858 770 109763642
Mucosal inflammation 22.83 9.81 544 824343 95597 109668815
Blood loss anaemia 22.79 9.81 220 824667 17805 109746607
Coronary arterial stent insertion 22.76 9.81 96 824791 5819 109758593
Neurotoxicity 22.75 9.81 203 824684 42004 109722408
Aortic valve incompetence 22.67 9.81 150 824737 10831 109753581
Vitamin B1 increased 22.54 9.81 15 824872 165 109764247
Itching scar 22.52 9.81 10 824877 44 109764368
Kidney fibrosis 22.43 9.81 78 824809 4314 109760098
Electrocardiogram J wave 22.43 9.81 12 824875 85 109764327
Eosinophilic granulomatosis with polyangiitis 22.42 9.81 28 824859 10658 109753754
Pneumonia 22.41 9.81 7086 817801 869628 108894784
Blood creatine increased 22.36 9.81 155 824732 11366 109753046
Vulvovaginal pruritus 22.36 9.81 65 824822 3266 109761146
Hepatic cytolysis 22.30 9.81 283 824604 54770 109709642
Blood creatinine abnormal 22.18 9.81 95 824792 5797 109758615
Electrocardiogram ST segment depression 22.08 9.81 90 824797 5371 109759041
Candida infection 22.07 9.81 240 824647 47769 109716643
Cytomegalovirus viraemia 21.93 9.81 64 824823 17700 109746712
Fibrillary glomerulonephritis 21.92 9.81 11 824876 67 109764345
Fulminant type 1 diabetes mellitus 21.89 9.81 52 824835 2311 109762101
Glucose urine present 21.88 9.81 51 824836 2238 109762174
Atheroembolism 21.87 9.81 20 824867 361 109764051
Cardiac failure chronic 21.82 9.81 177 824710 13634 109750778
Hyperplasia 21.81 9.81 40 824847 1478 109762934
Eyelid oedema 21.68 9.81 191 824696 15071 109749341
Mucosal membrane hyperplasia 21.67 9.81 10 824877 49 109764363
Acute graft versus host disease in skin 21.64 9.81 29 824858 10711 109753701
Angiopathy 21.64 9.81 125 824762 8605 109755807
Scleral discolouration 21.57 9.81 26 824861 654 109763758
Graft versus host disease in gastrointestinal tract 21.56 9.81 21 824866 8947 109755465
Product tampering 21.56 9.81 22 824865 457 109763955
Telangiectasia 21.54 9.81 45 824842 1832 109762580
Nipple inflammation 21.51 9.81 10 824877 50 109764362
Gastric ulcer 21.49 9.81 417 824470 39410 109725002
Hypertension 21.47 9.81 4215 820672 505869 109258543
Sleep disorder due to a general medical condition 21.44 9.81 267 824620 51845 109712567
Thrombotic cerebral infarction 21.42 9.81 28 824859 766 109763646
Drug effective for unapproved indication 21.42 9.81 46 824841 14121 109750291
Fluid intake reduced 21.38 9.81 106 824781 6880 109757532
Loose tooth 21.38 9.81 63 824824 3190 109761222
Acute respiratory failure 21.33 9.81 723 824164 74537 109689875
Rib deformity 21.32 9.81 16 824871 216 109764196
Foetal exposure during pregnancy 21.23 9.81 15 824872 7490 109756922
Laboratory test abnormal 21.22 9.81 218 824669 43861 109720551
Obsessive-compulsive disorder 21.11 9.81 14 824873 7227 109757185
Ballismus 21 9.81 18 824869 297 109764115
Coronary artery bypass 20.91 9.81 95 824792 5947 109758465
Pulmonary valve disease 20.91 9.81 19 824868 340 109764072
Troponin increased 20.87 9.81 325 824562 29441 109734971
Febrile bone marrow aplasia 20.79 9.81 64 824823 17401 109747011
Enterochromaffin cell hyperplasia 20.66 9.81 11 824876 77 109764335
Adenoma benign 20.66 9.81 36 824851 1277 109763135
Plasmapheresis 20.61 9.81 28 824859 796 109763616
Metastases to bone 20.58 9.81 143 824744 31229 109733183
Compartment syndrome 20.51 9.81 93 824794 5817 109758595
Helicobacter gastritis 20.48 9.81 54 824833 2562 109761850
Pseudoaldosteronism 20.46 9.81 18 824869 308 109764104
Myasthenia gravis 20.45 9.81 248 824639 21263 109743149
Band neutrophil percentage decreased 20.44 9.81 7 824880 12 109764400
Dissociation 20.43 9.81 26 824861 9816 109754596
Cardiac hypertrophy 20.42 9.81 45 824842 1902 109762510
Peritoneal dialysis complication 20.39 9.81 53 824834 2493 109761919
Asthma 20.36 9.81 2149 822738 248142 109516270
Listless 20.36 9.81 77 824810 4438 109759974
Cross sensitivity reaction 20.35 9.81 8 824879 5559 109758853
Benign neoplasm of adrenal gland 20.32 9.81 10 824877 58 109764354
Orbital myositis 20.31 9.81 16 824871 233 109764179
Stent placement 20.21 9.81 107 824780 7127 109757285
Abortion induced 20.20 9.81 18 824869 8001 109756411
Hyperprolactinaemia 20.15 9.81 12 824875 6563 109757849
Hallucination, visual 20.14 9.81 411 824476 39194 109725218
Snoring 20.10 9.81 102 824785 6682 109757730
Orthopnoea 20.07 9.81 146 824741 10875 109753537
Irritability 20.03 9.81 244 824643 47565 109716847
Exposure via ingestion 20.01 9.81 81 824806 4819 109759593
Blood cholinesterase decreased 19.88 9.81 21 824866 455 109763957
International normalised ratio increased 19.86 9.81 814 824073 85958 109678454
Peripheral ischaemia 19.86 9.81 146 824741 10912 109753500
Chondroma 19.84 9.81 6 824881 5 109764407
Acute pulmonary oedema 19.82 9.81 204 824683 16792 109747620
Complication of device insertion 19.78 9.81 22 824865 8816 109755596
Haemorrhage subepidermal 19.76 9.81 7 824880 14 109764398
Full blood count abnormal 19.75 9.81 553 824334 55499 109708913
Dermatomyositis 19.75 9.81 75 824812 4331 109760081
Hypertensive nephropathy 19.75 9.81 31 824856 1007 109763405
Femoral artery dissection 19.69 9.81 9 824878 43 109764369
Prostatomegaly 19.67 9.81 73 824814 4169 109760243
Blood lactate dehydrogenase increased 19.64 9.81 451 824436 43883 109720529
Carotid sinus syndrome 19.62 9.81 14 824873 174 109764238
Inhibitory drug interaction 19.59 9.81 81 824806 4866 109759546
Subarachnoid haemorrhage 19.58 9.81 321 824566 29381 109735031
Haematoma 19.53 9.81 573 824314 57903 109706509
Left ventricular enlargement 19.40 9.81 28 824859 843 109763569
Metabolic alkalosis 19.39 9.81 88 824799 5507 109758905
Vascular resistance systemic decreased 19.38 9.81 16 824871 250 109764162
Maternal exposure during breast feeding 19.34 9.81 4 824883 4234 109760178
Lecithin-cholesterol acyltransferase deficiency 19.32 9.81 6 824881 6 109764406
Vascular device infection 19.31 9.81 61 824826 16451 109747961
Left atrial enlargement 19.29 9.81 41 824846 1690 109762722
Iliac artery occlusion 19.24 9.81 19 824868 379 109764033
Fungal infection 19.18 9.81 265 824622 50541 109713871
Toxic skin eruption 19.13 9.81 300 824587 27215 109737197
Device dislocation 19.13 9.81 148 824739 31556 109732856
Pustular psoriasis 19.09 9.81 46 824841 13559 109750853
Gallbladder adenocarcinoma 19.07 9.81 12 824875 119 109764293
Cerebrovascular disorder 19.03 9.81 66 824821 3645 109760767
Suture rupture 19.01 9.81 25 824862 688 109763724
Hyperparathyroidism secondary 18.93 9.81 61 824826 3243 109761169
Hyperparathyroidism 18.88 9.81 67 824820 3743 109760669
Cholestasis 18.84 9.81 622 824265 63896 109700516
Staphylococcal infection 18.83 9.81 388 824499 69556 109694856
Dermatitis exfoliative 18.79 9.81 147 824740 11200 109753212
Pulmonary hypoplasia 18.75 9.81 9 824878 49 109764363
Pericardial disease 18.74 9.81 25 824862 698 109763714
Ventricular hyperkinesia 18.72 9.81 17 824870 304 109764108
Prostate cancer recurrent 18.68 9.81 29 824858 933 109763479
Dermatitis artefacta 18.67 9.81 10 824877 71 109764341
Eczema 18.63 9.81 687 824200 71606 109692806
Hip fracture 18.62 9.81 367 824520 34784 109729628
Microscopic polyangiitis 18.58 9.81 21 824866 492 109763920
Hypertensive urgency 18.57 9.81 32 824855 1125 109763287
Blood lactic acid abnormal 18.47 9.81 11 824876 98 109764314
Product solubility abnormal 18.47 9.81 32 824855 1130 109763282
Continuous haemodiafiltration 18.38 9.81 43 824844 1892 109762520
Spirometry abnormal 18.36 9.81 9 824878 5488 109758924
Dust allergy 18.32 9.81 11 824876 5990 109758422
Idiopathic pulmonary fibrosis 18.32 9.81 80 824807 4924 109759488
Liver carcinoma ruptured 18.31 9.81 17 824870 313 109764099
Blood sodium abnormal 18.31 9.81 35 824852 1335 109763077
Sinus rhythm 18.27 9.81 30 824857 1013 109763399
Blood uric acid increased 18.25 9.81 243 824644 21286 109743126
Hydronephrosis 18.25 9.81 235 824652 20430 109743982
Dysphonia 18.24 9.81 716 824171 75213 109689199
Parosmia 18.24 9.81 164 824723 13016 109751396
CD30 expression 18.22 9.81 10 824877 75 109764337
Urinary tract infection 18.21 9.81 2737 822150 323545 109440867
Unresponsive to stimuli 18.12 9.81 613 824274 63177 109701235
Rhinitis 18.10 9.81 252 824635 22293 109742119
Vasculitic rash 18.09 9.81 47 824840 2210 109762202
Microalbuminuria 18.05 9.81 33 824854 1216 109763196
Lung diffusion test decreased 18.05 9.81 39 824848 1626 109762786
Alanine aminotransferase abnormal 18.01 9.81 26 824861 9308 109755104
Deformity 17.98 9.81 30 824857 10130 109754282
Polyuria 17.96 9.81 207 824680 17531 109746881
Superficial spreading melanoma stage I 17.91 9.81 9 824878 55 109764357
Sedation 17.91 9.81 662 824225 69021 109695391
Giant cell arteritis 17.79 9.81 65 824822 3684 109760728
Guillain-Barre syndrome 17.69 9.81 139 824748 10605 109753807
Lip oedema 17.66 9.81 107 824780 7493 109756919
Gait spastic 17.62 9.81 37 824850 1512 109762900
Apathy 17.58 9.81 192 824695 16047 109748365
Pelvic neoplasm 17.58 9.81 16 824871 287 109764125
Atrioventricular dissociation 17.56 9.81 18 824869 376 109764036
Metastases to central nervous system 17.56 9.81 99 824788 22718 109741694
Stillbirth 17.56 9.81 5 824882 4259 109760153
Skin wrinkling 17.55 9.81 37 824850 1516 109762896
Cardiorenal syndrome 17.54 9.81 42 824845 1876 109762536
Traumatic haemorrhage 17.54 9.81 41 824846 1803 109762609
Aplasia pure red cell 17.51 9.81 127 824760 9451 109754961
Vasculitis 17.50 9.81 370 824517 35503 109728909
Nephropathy 17.34 9.81 165 824722 13302 109751110
Ultrasound uterus abnormal 17.33 9.81 7 824880 23 109764389
Blood alkaline phosphatase increased 17.30 9.81 670 824217 70265 109694147
Reaction to preservatives 17.23 9.81 15 824872 253 109764159
Skin toxicity 17.20 9.81 39 824848 11744 109752668
Phaeochromocytoma 17.15 9.81 26 824861 819 109763593
Venous oxygen saturation decreased 17.15 9.81 9 824878 61 109764351
Malignant hypertension 17.13 9.81 38 824849 1613 109762799
Hypoglossal nerve paralysis 17.10 9.81 7 824880 24 109764388
Maternal exposure during delivery 17.05 9.81 3 824884 3562 109760850
Alveolitis 17.04 9.81 72 824815 4367 109760045
Henoch-Schonlein purpura 17.01 9.81 63 824824 3594 109760818
Suspected suicide attempt 16.90 9.81 17 824870 347 109764065
Feeling hot 16.85 9.81 534 824353 90572 109673840
Coronary artery surgery 16.82 9.81 12 824875 149 109764263
Cold sweat 16.79 9.81 244 824643 21787 109742625
Pharyngeal oedema 16.76 9.81 192 824695 16236 109748176
Sinus disorder 16.76 9.81 340 824547 32388 109732024
Malpositioned teeth 16.75 9.81 8 824879 43 109764369
Obstructive airways disorder 16.74 9.81 457 824430 45692 109718720
Viral mutation identified 16.74 9.81 6 824881 4413 109759999
Platelet count decreased 16.74 9.81 1964 822923 228479 109535933
Bladder sphincter atony 16.74 9.81 14 824873 223 109764189
Macroglossia 16.74 9.81 35 824852 1426 109762986
Device breakage 16.71 9.81 50 824837 13719 109750693
Pseudoporphyria 16.71 9.81 25 824862 778 109763634
Tricuspid valve calcification 16.62 9.81 5 824882 4 109764408
Spontaneous hyphaema 16.62 9.81 6 824881 13 109764399
Craniectomy 16.62 9.81 6 824881 13 109764399
Product size issue 16.61 9.81 27 824860 904 109763508
Pericardial haemorrhage 16.57 9.81 80 824807 5137 109759275
Herpes simplex 16.55 9.81 61 824826 15703 109748709
Diverticulum 16.54 9.81 183 824704 15343 109749069
Orbital swelling 16.52 9.81 10 824877 92 109764320
Electrocardiogram QRS complex prolonged 16.50 9.81 159 824728 12862 109751550
Vulvovaginal burning sensation 16.50 9.81 43 824844 2026 109762386
Hypermagnesaemia 16.44 9.81 37 824850 1586 109762826
Haemorrhagic diathesis 16.38 9.81 104 824783 7404 109757008
Oral candidiasis 16.35 9.81 235 824652 44525 109719887
Blood sodium increased 16.34 9.81 83 824804 5440 109758972
Splenic rupture 16.32 9.81 50 824837 2587 109761825
Blood chloride increased 16.29 9.81 92 824795 6280 109758132
Pulseless electrical activity 16.28 9.81 194 824693 16563 109747849
Adrenal adenoma 16.23 9.81 35 824852 1457 109762955
Urinary incontinence 16.20 9.81 476 824411 48111 109716301
Sinus arrhythmia 16.19 9.81 44 824843 2126 109762286
Gene mutation 16.15 9.81 3 824884 3426 109760986
Autoimmune enteropathy 16.12 9.81 9 824878 70 109764342
Wrong patient 16.12 9.81 35 824852 1464 109762948
Upper respiratory tract inflammation 16.09 9.81 70 824817 4301 109760111
Monoparesis 16.07 9.81 72 824815 4481 109759931
Headache 16.06 9.81 6129 818758 876248 108888164
Choking 16.06 9.81 178 824709 14932 109749480
Urinary occult blood 16.04 9.81 8 824879 48 109764364
Colloid brain cyst 16.03 9.81 6 824881 15 109764397
Choroidal detachment 16.02 9.81 24 824863 748 109763664
Nodal arrhythmia 16.01 9.81 44 824843 2140 109762272
Claustrophobia 16.00 9.81 36 824851 1543 109762869
Blood urine present 15.97 9.81 262 824625 23983 109740429
Sinonasal obstruction 15.96 9.81 17 824870 372 109764040
Amylase increased 15.93 9.81 153 824734 12366 109752046
Hypertensive cardiomyopathy 15.92 9.81 17 824870 373 109764039
Blindness transient 15.90 9.81 87 824800 5869 109758543
Encephalitis toxic 15.86 9.81 15 824872 283 109764129
Faecal calprotectin increased 15.85 9.81 16 824871 6703 109757709
Rash vesicular 15.85 9.81 56 824831 14596 109749816
Adrenal neoplasm 15.84 9.81 20 824867 528 109763884
Peripheral vascular disorder 15.84 9.81 114 824773 8462 109755950
Clostridium test positive 15.83 9.81 137 824750 10756 109753656
Thrombotic thrombocytopenic purpura 15.82 9.81 99 824788 7012 109757400
Myelodysplastic syndrome 15.82 9.81 191 824696 37293 109727119
Affective disorder 15.78 9.81 38 824849 11203 109753209
Dry eye 15.77 9.81 307 824580 55486 109708926
Sarcoidosis 15.76 9.81 45 824842 12534 109751878
Gastric cancer 15.76 9.81 138 824749 10870 109753542
Cytomegalovirus chorioretinitis 15.67 9.81 18 824869 7110 109757302
Brain stem haemorrhage 15.65 9.81 39 824848 1787 109762625
Shock haemorrhagic 15.64 9.81 288 824599 26959 109737453
Mammary duct ectasia 15.62 9.81 4 824883 0 109764412
Onychomalacia 15.62 9.81 4 824883 0 109764412
Exercise tolerance decreased 15.61 9.81 148 824739 11919 109752493
Hypothyroidism 15.59 9.81 679 824208 72220 109692192
Blood pressure diastolic decreased 15.57 9.81 364 824523 35521 109728891
Wrong patient received product 15.53 9.81 94 824793 6580 109757832
Body temperature decreased 15.52 9.81 373 824514 36562 109727850
Stomatitis haemorrhagic 15.52 9.81 14 824873 248 109764164
Abdominal pain lower 15.51 9.81 376 824511 36907 109727505
Accidental overdose 15.47 9.81 501 824386 51333 109713079
Crystal arthropathy 15.43 9.81 14 824873 250 109764162
Base excess decreased 15.43 9.81 17 824870 387 109764025
Food interaction 15.42 9.81 43 824844 2109 109762303
Gingival atrophy 15.41 9.81 9 824878 77 109764335
Blood potassium abnormal 15.41 9.81 65 824822 3940 109760472
Surfactant protein increased 15.39 9.81 7 824880 33 109764379
Enthesopathy 15.37 9.81 45 824842 12433 109751979
Product dispensing error 15.34 9.81 188 824699 16157 109748255
Type I hypersensitivity 15.34 9.81 15 824872 6378 109758034
Cell marker increased 15.33 9.81 22 824865 659 109763753
Urine flow decreased 15.32 9.81 33 824854 1373 109763039
Cardiac valve disease 15.31 9.81 91 824796 6330 109758082
Polyarthritis 15.29 9.81 81 824806 18882 109745530
Immunosuppressant drug level increased 15.27 9.81 144 824743 11580 109752832
Occult blood 15.24 9.81 39 824848 1817 109762595
Uveitis 15.23 9.81 97 824790 21613 109742799
Skin candida 15.22 9.81 45 824842 2283 109762129
Varicella zoster virus infection 15.21 9.81 15 824872 6353 109758059
Gingival hypoplasia 15.20 9.81 5 824882 7 109764405
Fear of injection 15.15 9.81 27 824860 8884 109755528
Viral infection 15.14 9.81 292 824595 52847 109711565
Galactorrhoea 15.14 9.81 6 824881 4149 109760263
Lichen nitidus 15.13 9.81 11 824876 141 109764271
Venoocclusive disease 15.12 9.81 15 824872 6335 109758077
Epstein-Barr viraemia 15.10 9.81 4 824883 3575 109760837
Head discomfort 15.10 9.81 212 824675 18788 109745624
Peritonitis bacterial 15.06 9.81 132 824755 10401 109754011
IgA nephropathy 15.05 9.81 55 824832 3118 109761294
Albumin urine present 15.04 9.81 23 824864 730 109763682
Pulmonary hypertension 15.02 9.81 528 824359 54692 109709720
Dactylitis 15.01 9.81 6 824881 4127 109760285
Respiratory tract congestion 14.97 9.81 318 824569 30539 109733873
Tumour haemorrhage 14.94 9.81 78 824809 5167 109759245
Carcinoid tumour of the stomach 14.94 9.81 12 824875 180 109764232
Mouth swelling 14.91 9.81 100 824787 7254 109757158
Electrocardiogram T wave amplitude decreased 14.91 9.81 24 824863 797 109763615
Abnormal loss of weight 14.90 9.81 129 824758 10128 109754284
Colitis ischaemic 14.90 9.81 200 824687 17550 109746862
Neuritis 14.89 9.81 20 824867 7379 109757033
Pancreatitis haemorrhagic 14.88 9.81 27 824860 989 109763423
Premature rupture of membranes 14.88 9.81 8 824879 4629 109759783
Bladder catheterisation 14.87 9.81 29 824858 1123 109763289
Portal hypertension 14.83 9.81 26 824861 8611 109755801
Cardiac pacemaker insertion 14.83 9.81 89 824798 6212 109758200
Sex hormone binding globulin increased 14.81 9.81 5 824882 8 109764404
High density lipoprotein decreased 14.81 9.81 83 824804 5650 109758762
Mycobacterium marinum infection 14.77 9.81 23 824864 742 109763670
Neoplasm skin 14.74 9.81 55 824832 3149 109761263
Hypertransaminasaemia 14.74 9.81 113 824774 24142 109740270
Retroperitoneal haematoma 14.68 9.81 87 824800 6044 109758368
Organ failure 14.68 9.81 73 824814 4744 109759668
Transplant rejection 14.67 9.81 115 824772 24452 109739960
Intestinal angioedema 14.63 9.81 28 824859 1069 109763343
Spondylitis 14.62 9.81 40 824847 11298 109753114
Physical examination abnormal 14.61 9.81 19 824868 517 109763895
Oesophageal carcinoma 14.61 9.81 41 824846 11483 109752929
Ascites 14.57 9.81 839 824048 91969 109672443
Pernicious anaemia 14.57 9.81 23 824864 751 109763661
Intracranial haematoma 14.54 9.81 27 824860 1007 109763405
Seronegative arthritis 14.50 9.81 50 824837 13127 109751285
Peptic ulcer 14.49 9.81 102 824785 7517 109756895
Impaired insulin secretion 14.46 9.81 8 824879 61 109764351
Pelvic cyst 14.46 9.81 8 824879 61 109764351
Spinal fusion surgery 14.46 9.81 29 824858 9127 109755285
Injection site haemorrhage 14.43 9.81 167 824720 32861 109731551
Tenderness 14.41 9.81 145 824742 29292 109735120
Burns second degree 14.40 9.81 103 824784 7630 109756782
Skin induration 14.40 9.81 68 824819 4327 109760085
Sexual dysfunction 14.36 9.81 26 824861 8504 109755908
Milk-alkali syndrome 14.31 9.81 40 824847 1965 109762447
Injection site rash 14.28 9.81 109 824778 23310 109741102
Gastric pH increased 14.25 9.81 8 824879 63 109764349
Gastritis 14.25 9.81 512 824375 53187 109711225
BK virus infection 14.24 9.81 50 824837 13056 109751356
Lipodystrophy acquired 14.23 9.81 8 824879 4516 109759896
Muscular dystrophy 14.20 9.81 13 824874 235 109764177
Genital haemorrhage 14.19 9.81 20 824867 7232 109757180
Cholestatic liver injury 14.18 9.81 99 824788 7277 109757135
Ventricular failure 14.15 9.81 19 824868 534 109763878
Device deployment issue 14.15 9.81 7 824880 4246 109760166
Hyperglycaemic hyperosmolar nonketotic syndrome 14.14 9.81 52 824835 2957 109761455
Blood electrolytes abnormal 14.02 9.81 41 824846 2067 109762345
Renal mass 13.99 9.81 59 824828 3576 109760836
Hallucination, gustatory 13.94 9.81 8 824879 66 109764346
Noninfective gingivitis 13.91 9.81 40 824847 1997 109762415
5-hydroxyindolacetic acid increased 13.90 9.81 10 824877 126 109764286
Burning feet syndrome 13.89 9.81 13 824874 242 109764170
Lymphadenopathy 13.86 9.81 366 824521 63469 109700943
Lymphocyte count decreased 13.84 9.81 323 824564 56920 109707492
Hypertensive angiopathy 13.84 9.81 9 824878 95 109764317
FEV1/FVC ratio decreased 13.83 9.81 14 824873 288 109764124
Poor quality sleep 13.83 9.81 290 824597 27787 109736625
Rectal ulcer haemorrhage 13.80 9.81 15 824872 336 109764076
Acute graft versus host disease in intestine 13.80 9.81 13 824874 5626 109758786
Herbal interaction 13.76 9.81 20 824867 606 109763806
Drug dispensed to wrong patient 13.74 9.81 22 824865 727 109763685
Intermenstrual bleeding 13.69 9.81 19 824868 6915 109757497
Cellulitis of male external genital organ 13.64 9.81 7 824880 45 109764367
Benign gastrointestinal neoplasm 13.64 9.81 10 824877 130 109764282
Peritonitis 13.61 9.81 329 824558 32278 109732134
Vertigo positional 13.61 9.81 62 824825 3886 109760526
Acute myeloid leukaemia recurrent 13.60 9.81 11 824876 5128 109759284
Aortic arteriosclerosis 13.58 9.81 133 824754 10805 109753607
Pharyngitis streptococcal 13.54 9.81 52 824835 13225 109751187
Fracture 13.53 9.81 260 824627 24528 109739884
Nail ridging 13.49 9.81 19 824868 559 109763853
Mite allergy 13.48 9.81 14 824873 5789 109758623
Oculomucocutaneous syndrome 13.42 9.81 15 824872 347 109764065
Urine albumin/creatinine ratio 13.41 9.81 6 824881 27 109764385
Pulse volume decreased 13.41 9.81 4 824883 3 109764409
Yellow nail syndrome 13.41 9.81 4 824883 3 109764409
Hospitalisation 13.35 9.81 899 823988 141594 109622818
Cardiac valve sclerosis 13.30 9.81 9 824878 102 109764310
Nightmare 13.30 9.81 382 824505 38481 109725931
Cholecystitis 13.30 9.81 269 824618 25613 109738799
Psychiatric decompensation 13.29 9.81 14 824873 5751 109758661
Cholangitis 13.28 9.81 183 824704 16152 109748260
Fear of disease 13.25 9.81 31 824856 1364 109763048
Bronchial hyperreactivity 13.23 9.81 57 824830 3487 109760925
Echocardiogram abnormal 13.23 9.81 47 824840 2627 109761785
Peritoneal dialysis 13.21 9.81 24 824863 880 109763532
Renal tubular necrosis 13.18 9.81 309 824578 30166 109734246
JC virus infection 13.18 9.81 12 824875 5278 109759134
Aortic aneurysm rupture 13.17 9.81 31 824856 1369 109763043
Disturbance in social behaviour 13.17 9.81 11 824876 5047 109759365
Anticoagulation drug level abnormal 13.15 9.81 14 824873 306 109764106
Mitral valve stenosis 13.14 9.81 31 824856 1371 109763041
Incorrect dose administered by device 13.13 9.81 19 824868 6795 109757617
Prostatic operation 13.12 9.81 15 824872 356 109764056
Cellulitis 13.09 9.81 1101 823786 124915 109639497
Rheumatoid nodule 13.08 9.81 93 824794 20203 109744209
Anaemia Heinz body 13.07 9.81 6 824881 29 109764383
Epstein-Barr virus associated lymphoproliferative disorder 13.06 9.81 10 824877 4792 109759620
Mitochondrial toxicity 13.00 9.81 4 824883 3241 109761171
Respiratory rate increased 12.99 9.81 261 824626 24822 109739590
Tumour rupture 12.96 9.81 20 824867 640 109763772
Renal artery occlusion 12.96 9.81 11 824876 179 109764233
Cerebrovascular arteriovenous malformation 12.94 9.81 9 824878 107 109764305
Dermatitis exfoliative generalised 12.94 9.81 132 824755 10840 109753572
Morbid thoughts 12.93 9.81 24 824863 895 109763517
Hypoglycaemic coma 12.92 9.81 78 824809 5455 109758957
Thromboangiitis obliterans 12.92 9.81 7 824880 51 109764361
Gestational diabetes 12.91 9.81 22 824865 7367 109757045
Secondary hypertension 12.87 9.81 19 824868 584 109763828
Osteoma 12.87 9.81 9 824878 108 109764304
Muscle spasticity 12.84 9.81 355 824532 35560 109728852
Basal ganglia haemorrhage 12.82 9.81 37 824850 1851 109762561
Acute lung injury 12.80 9.81 52 824835 3099 109761313
Colitis 12.77 9.81 628 824259 101695 109662717
Nasal crusting 12.76 9.81 23 824864 838 109763574
Epididymal cyst 12.71 9.81 5 824882 15 109764397
Post-traumatic amnestic disorder 12.70 9.81 7 824880 53 109764359
Optic nerve injury 12.69 9.81 21 824866 714 109763698
Diabetic ketoacidosis 12.68 9.81 407 824480 41651 109722761
Concomitant disease progression 12.67 9.81 57 824830 3553 109760859
Neuroendocrine tumour 12.67 9.81 33 824854 1554 109762858
Hyperkaliuria 12.66 9.81 11 824876 185 109764227
Insulin C-peptide increased 12.66 9.81 11 824876 185 109764227
Blood pressure fluctuation 12.64 9.81 681 824206 74143 109690269
Oral discharge 12.63 9.81 13 824874 273 109764139
Bacteriuria 12.63 9.81 31 824856 1407 109763005
Virologic failure 12.61 9.81 11 824876 4941 109759471
Carbohydrate metabolism disorder 12.60 9.81 6 824881 32 109764380
Renal artery thrombosis 12.60 9.81 18 824869 537 109763875
Gastric volvulus 12.59 9.81 7 824880 54 109764358
Urogenital infection fungal 12.59 9.81 7 824880 54 109764358
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits 12.59 9.81 30 824857 1336 109763076
Extremity necrosis 12.58 9.81 59 824828 3743 109760669
Bile duct cancer 12.52 9.81 26 824861 1054 109763358
Pneumothorax traumatic 12.52 9.81 13 824874 276 109764136
Alcohol abuse 12.49 9.81 11 824876 4918 109759494
Treatment noncompliance 12.47 9.81 665 824222 72325 109692087
Epiglottic oedema 12.46 9.81 16 824871 430 109763982
Diabetic foot 12.44 9.81 62 824825 4033 109760379
Joint effusion 12.42 9.81 98 824789 20807 109743605
Hereditary haemorrhagic telangiectasia 12.41 9.81 8 824879 83 109764329
Multiple sclerosis 12.41 9.81 127 824760 25571 109738841
Beta 2 microglobulin urine increased 12.40 9.81 10 824877 151 109764261
Secondary immunodeficiency 12.39 9.81 10 824877 4666 109759746
Dry skin 12.38 9.81 948 823939 106705 109657707
Acquired cystic kidney disease 12.38 9.81 7 824880 56 109764356
Sodium retention 12.37 9.81 12 824875 234 109764178
Drug level below therapeutic 12.37 9.81 45 824842 11628 109752784
Cardiovascular insufficiency 12.37 9.81 53 824834 3235 109761177
Cerebral toxoplasmosis 12.36 9.81 4 824883 3138 109761274
Urinary casts present 12.34 9.81 9 824878 116 109764296
Skin hypertrophy 12.34 9.81 72 824815 4975 109759437
Norepinephrine increased 12.33 9.81 8 824879 84 109764328
Osteopenia 12.33 9.81 106 824781 22103 109742309
Blood glucose abnormal 12.32 9.81 149 824738 12767 109751645
Pulmonary valve stenosis 12.29 9.81 10 824877 153 109764259
Systemic candida 12.27 9.81 36 824851 9938 109754474
Atrial natriuretic peptide increased 12.25 9.81 5 824882 17 109764395
Viral haemorrhagic cystitis 12.24 9.81 5 824882 3394 109761018
Porphyria non-acute 12.23 9.81 21 824866 736 109763676
Palatal oedema 12.22 9.81 34 824853 1666 109762746
Water intoxication 12.21 9.81 24 824863 935 109763477
Dilatation atrial 12.18 9.81 59 824828 3793 109760619
Conjunctival haemorrhage 12.15 9.81 88 824799 6545 109757867
Medical device site thrombosis 12.15 9.81 9 824878 119 109764293
Product coating issue 12.15 9.81 9 824878 119 109764293
Brain contusion 12.14 9.81 33 824854 1595 109762817
Rhinovirus infection 12.13 9.81 46 824841 11743 109752669
Pure white cell aplasia 12.13 9.81 10 824877 156 109764256
Hair colour changes 12.10 9.81 68 824819 4633 109759779
Rebound effect 12.08 9.81 63 824824 14743 109749669
Scleroedema 12.08 9.81 10 824877 157 109764255
Oncologic complication 12.07 9.81 16 824871 444 109763968
Haemorrhagic cyst 12.03 9.81 15 824872 391 109764021
Agitation 12.02 9.81 705 824182 112346 109652066
Steal syndrome 12.00 9.81 4 824883 6 109764406
Floppy iris syndrome 11.99 9.81 14 824873 340 109764072
Dermatitis infected 11.98 9.81 17 824870 504 109763908
Blood pressure orthostatic 11.95 9.81 8 824879 89 109764323
Intermittent claudication 11.93 9.81 57 824830 3644 109760768
Neurosensory hypoacusis 11.93 9.81 12 824875 245 109764167
Hypertrophic cardiomyopathy 11.91 9.81 51 824836 3112 109761300
Gastrointestinal stromal tumour 11.90 9.81 39 824848 2092 109762320
Total lung capacity abnormal 11.89 9.81 10 824877 4573 109759839
Blood creatine phosphokinase abnormal 11.89 9.81 20 824867 689 109763723
Somnolence 11.89 9.81 2452 822435 294997 109469415
Paranoia 11.89 9.81 108 824779 22266 109742146
Metastases to fallopian tube 11.88 9.81 7 824880 61 109764351
Adrenocortical carcinoma 11.87 9.81 8 824879 90 109764322
Mouth breathing 11.86 9.81 13 824874 294 109764118
Q fever 11.86 9.81 13 824874 294 109764118
Chronic gastritis 11.83 9.81 75 824812 5336 109759076
Gastric antral vascular ectasia 11.81 9.81 27 824860 1170 109763242
Electrocardiogram QT prolonged 11.80 9.81 955 823932 108005 109656407
Ureteric cancer 11.79 9.81 13 824874 296 109764116
Laryngeal cancer 11.79 9.81 21 824866 758 109763654
Erythema multiforme 11.76 9.81 222 824665 20875 109743537
Incorrect product administration duration 11.76 9.81 97 824790 20401 109744011
Sensitivity to weather change 11.76 9.81 37 824850 9991 109754421
Nail discolouration 11.73 9.81 56 824831 3579 109760833
Hepatosplenomegaly 11.73 9.81 21 824866 6898 109757514
Systemic mycosis 11.72 9.81 7 824880 3822 109760590
Glucose tolerance increased 11.72 9.81 3 824884 0 109764412
Oesophageal adenocarcinoma stage III 11.72 9.81 3 824884 0 109764412
Macular telangiectasia 11.72 9.81 3 824884 0 109764412
Protein albumin ratio decreased 11.72 9.81 3 824884 0 109764412
Diabetic enteropathy 11.72 9.81 3 824884 0 109764412
Eye allergy 11.70 9.81 25 824862 1034 109763378
Cystitis haemorrhagic 11.70 9.81 49 824838 12160 109752252
Adrenal cyst 11.70 9.81 12 824875 251 109764161
Vagus nerve disorder 11.69 9.81 7 824880 63 109764349
Gastrointestinal polyp haemorrhage 11.68 9.81 21 824866 764 109763648
Skin discolouration 11.66 9.81 462 824425 48584 109715828
Flour sensitivity 11.63 9.81 5 824882 20 109764392
Retroperitoneal oedema 11.63 9.81 5 824882 20 109764392
Ventricular drainage 11.63 9.81 5 824882 20 109764392
Lacrimal disorder 11.60 9.81 17 824870 519 109763893
Femoral artery embolism 11.60 9.81 7 824880 64 109764348
Fine motor skill dysfunction 11.60 9.81 18 824869 6256 109758156
Catarrh 11.59 9.81 94 824793 7241 109757171
Acute motor-sensory axonal neuropathy 11.56 9.81 17 824870 521 109763891
Macrophages increased 11.54 9.81 12 824875 255 109764157
Withdrawal hypertension 11.54 9.81 15 824872 408 109764004
Leg amputation 11.52 9.81 62 824825 4156 109760256
Hypogammaglobulinaemia 11.52 9.81 95 824792 19981 109744431
Apical granuloma 11.51 9.81 7 824880 65 109764347
Genitourinary tract neoplasm 11.51 9.81 7 824880 65 109764347
Hospice care 11.51 9.81 143 824744 12330 109752082
Synovial cyst 11.50 9.81 45 824842 11385 109753027
Gastrointestinal ischaemia 11.48 9.81 17 824870 524 109763888
Arteriospasm coronary 11.47 9.81 111 824776 8989 109755423
Cystic fibrosis 11.47 9.81 11 824876 4720 109759692
Hypoglycaemic unconsciousness 11.46 9.81 27 824860 1193 109763219
Tremor 11.46 9.81 1698 823189 200534 109563878
Mean platelet volume increased 11.45 9.81 32 824855 1572 109762840
Atrial flutter 11.43 9.81 249 824638 24013 109740399
Electrocardiogram U wave present 11.37 9.81 9 824878 132 109764280
Lichenification 11.36 9.81 24 824863 985 109763427
Adrenocorticotropic hormone deficiency 11.36 9.81 39 824848 2143 109762269
Speech disorder 11.34 9.81 565 824322 61004 109703408
Blood cholinesterase increased 11.33 9.81 7 824880 67 109764345
Polycystic liver disease 11.33 9.81 10 824877 172 109764240
Fibrous dysplasia of jaw 11.29 9.81 4 824883 8 109764404
Bile duct stone 11.27 9.81 83 824804 6206 109758206
Subclavian steal syndrome 11.27 9.81 6 824881 42 109764370
Renal tubular atrophy 11.26 9.81 40 824847 2236 109762176
Phaeochromocytoma malignant 11.25 9.81 7 824880 68 109764344
Tongue discomfort 11.21 9.81 47 824840 2841 109761571
Blood cholesterol decreased 11.17 9.81 45 824842 2671 109761741
Hyperthermia 11.17 9.81 103 824784 21169 109743243
Renal cyst 11.11 9.81 194 824693 17978 109746434
Pleural mass 11.10 9.81 8 824879 101 109764311
Injection site discolouration 11.09 9.81 33 824854 9070 109755342
Brain abscess 11.09 9.81 21 824866 6753 109757659
Blood pressure difference of extremities 11.09 9.81 5 824882 23 109764389
Antidepressant drug level below therapeutic 11.09 9.81 5 824882 23 109764389
Stent malfunction 11.08 9.81 7 824880 70 109764342
Product name confusion 11.08 9.81 11 824876 221 109764191
Sudden death 11.07 9.81 249 824638 24146 109740266
Pancreatic carcinoma 11.05 9.81 164 824723 14708 109749704
Ileocolostomy 11.04 9.81 6 824881 44 109764368
Hyperplastic cholecystopathy 11.04 9.81 11 824876 222 109764190
Temperature intolerance 11.02 9.81 60 824827 13890 109750522
Leukocyturia 11.02 9.81 40 824847 2260 109762152
Analgesic drug level increased 11.01 9.81 8 824879 3938 109760474
Vomiting 10.98 9.81 7181 817706 903494 108860918
Femoral hernia 10.98 9.81 4 824883 9 109764403
Visual acuity reduced 10.94 9.81 316 824571 31857 109732555
Lung hernia 10.91 9.81 7 824880 72 109764340
Face oedema 10.91 9.81 327 824560 33142 109731270
Reaction to excipient 10.89 9.81 37 824850 2022 109762390
Respiratory distress 10.88 9.81 623 824264 68251 109696161
Streptococcal infection 10.88 9.81 43 824844 10847 109753565
Pelvic fracture 10.88 9.81 157 824730 13997 109750415
Lung hyperinflation 10.88 9.81 39 824848 2190 109762222
Parkinsonism 10.87 9.81 229 824658 21958 109742454
Postoperative renal failure 10.87 9.81 10 824877 182 109764230
Renal tubular injury 10.86 9.81 49 824838 3059 109761353
Foot operation 10.84 9.81 24 824863 7289 109757123
Haemorrhagic cerebral infarction 10.84 9.81 30 824857 1465 109762947
Oesophageal carcinoma recurrent 10.83 9.81 7 824880 73 109764339
Hyperinsulinaemia 10.83 9.81 12 824875 275 109764137
Gastroenteritis 10.81 9.81 372 824515 38428 109725984
Electrocardiogram T wave inversion 10.78 9.81 76 824811 5604 109758808
Stasis dermatitis 10.77 9.81 34 824853 1788 109762624
Hyperthermia malignant 10.76 9.81 8 824879 3892 109760520
Blood glucose fluctuation 10.76 9.81 96 824791 7602 109756810
Blood pressure systolic abnormal 10.76 9.81 252 824635 24598 109739814
Cystitis 10.76 9.81 599 824288 65437 109698975
Cardiac murmur 10.74 9.81 250 824637 24378 109740034
Small intestinal haemorrhage 10.72 9.81 65 824822 4553 109759859
Anxiety 10.72 9.81 2343 822544 342735 109421677
Platelet aggregation decreased 10.71 9.81 6 824881 47 109764365
Leukaemoid reaction 10.71 9.81 15 824872 439 109763973
Left ventricular failure 10.69 9.81 131 824756 11258 109753154
Cytopenia 10.69 9.81 159 824728 29957 109734455
Pleuroperitoneal communication 10.69 9.81 4 824883 10 109764402
Blood magnesium decreased 10.67 9.81 209 824678 19787 109744625
Relapsing-remitting multiple sclerosis 10.65 9.81 37 824850 2045 109762367
Leukaemia recurrent 10.65 9.81 5 824882 3126 109761286
Stenotrophomonas infection 10.65 9.81 17 824870 5841 109758571
Myocardial rupture 10.62 9.81 12 824875 281 109764131
Psychological trauma 10.61 9.81 32 824855 1641 109762771
Cytomegalovirus colitis 10.61 9.81 23 824864 7038 109757374
Change of bowel habit 10.60 9.81 46 824841 2823 109761589
Petechiae 10.58 9.81 238 824649 23079 109741333
Pallor 10.57 9.81 519 824368 55948 109708464
Splenic cyst 10.56 9.81 12 824875 283 109764129
Brain natriuretic peptide increased 10.55 9.81 129 824758 11080 109753332
Anal fissure 10.53 9.81 38 824849 9843 109754569
Duodenal ulcer repair 10.52 9.81 7 824880 77 109764335
Bifascicular block 10.52 9.81 14 824873 390 109764022
Bicuspid aortic valve 10.51 9.81 6 824881 49 109764363
Nephritis 10.50 9.81 80 824807 6046 109758366
Epstein-Barr virus infection reactivation 10.49 9.81 9 824878 4075 109760337
Sudden hearing loss 10.48 9.81 39 824848 2230 109762182
Bone cyst 10.46 9.81 7 824880 3596 109760816
Cerebral arteriosclerosis 10.46 9.81 21 824866 831 109763581
Periarticular disorder 10.45 9.81 5 824882 27 109764385
Nitritoid reaction 10.45 9.81 5 824882 27 109764385
Rheumatoid lung 10.44 9.81 10 824877 4294 109760118
Rhythm idioventricular 10.42 9.81 20 824867 765 109763647
Perennial allergy 10.42 9.81 4 824883 11 109764401
Marasmus 10.41 9.81 32 824855 1659 109762753
Loss of employment 10.39 9.81 6 824881 3338 109761074
Retinal vein occlusion 10.34 9.81 58 824829 3949 109760463
Hepatic cancer 10.34 9.81 128 824759 11028 109753384
Atrial enlargement 10.31 9.81 25 824862 1126 109763286
Full blood count decreased 10.30 9.81 313 824574 31786 109732626
Eye injury 10.27 9.81 27 824860 7728 109756684
Peripheral embolism 10.27 9.81 36 824851 1999 109762413
Internal fixation of fracture 10.25 9.81 16 824871 517 109763895
Retinal ischaemia 10.25 9.81 23 824864 984 109763428
Ureterolithiasis 10.25 9.81 62 824825 4340 109760072
Tuberculosis 10.25 9.81 84 824803 17690 109746722
Biopsy kidney 10.24 9.81 11 824876 243 109764169
Mycobacterium chelonae infection 10.23 9.81 5 824882 3055 109761357
Primary hypoparathyroidism 10.21 9.81 6 824881 52 109764360
Pupil fixed 10.20 9.81 56 824831 3782 109760630
Therapeutic product effect delayed 10.19 9.81 11 824876 4468 109759944
Haemorrhoids 10.18 9.81 343 824544 35329 109729083
Venous aneurysm 10.17 9.81 4 824883 12 109764400
Porphyrins urine increased 10.16 9.81 5 824882 29 109764383
Leukaemic infiltration renal 10.16 9.81 5 824882 29 109764383
Anal inflammation 10.14 9.81 3 824884 2493 109761919
Calcium ionised decreased 10.14 9.81 18 824869 648 109763764
Pneumonia aspiration 10.13 9.81 720 824167 80513 109683899
Animal bite 10.11 9.81 5 824882 3034 109761378
Blood pressure orthostatic decreased 10.10 9.81 17 824870 586 109763826
Hypernatraemia 10.06 9.81 188 824699 17645 109746767
Lipoma 10.04 9.81 57 824830 3898 109760514
Anorexia nervosa 10.04 9.81 12 824875 299 109764113
Tachyarrhythmia 10.04 9.81 100 824787 8161 109756251
Amputation 10.03 9.81 22 824865 927 109763485
Therapeutic product effect increased 10.02 9.81 32 824855 1693 109762719
Acquired gene mutation 10.00 9.81 4 824883 2750 109761662
Post procedural pneumonia 10.00 9.81 9 824878 159 109764253
Microcytic anaemia 9.99 9.81 80 824807 6138 109758274
Chapped lips 9.96 9.81 48 824839 3080 109761332
Haematocrit abnormal 9.93 9.81 32 824855 1701 109762711
Epinephrine increased 9.93 9.81 4 824883 13 109764399
Lichen planus 9.92 9.81 51 824836 3359 109761053
Vital functions abnormal 9.89 9.81 24 824863 1081 109763331
Immune effector cell-associated neurotoxicity syndrome 9.89 9.81 67 824820 14715 109749697
Mesenteric artery embolism 9.88 9.81 7 824880 86 109764326
Amyloid related imaging abnormality-oedema/effusion 9.87 9.81 30 824857 1545 109762867
Tardive dyskinesia 9.87 9.81 60 824827 13519 109750893
Kidney small 9.86 9.81 11 824876 254 109764158
Tic 9.86 9.81 7 824880 3486 109760926
Product label on wrong product 9.84 9.81 6 824881 56 109764356
Electrocardiogram QRS complex shortened 9.81 9.81 20 824867 800 109763612

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07FB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB12 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C08CA01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08CA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08GA02 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
CALCIUM CHANNEL BLOCKERS AND DIURETICS
Calcium channel blockers and diuretics
ATC C09BB03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB13 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB14 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09DB01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB09 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX08 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX09 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09XA53 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C09XA54 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX09 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX14 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX19 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX23 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX24 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA CS M0006414 Dihydropyridines
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175421 Dihydropyridine Calcium Channel Blocker
FDA EPC N0000175566 Calcium Channel Blocker
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:38215 calcium channel blocker
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
MeSH PA D049990 Membrane Transport Modulators
FDA MoA N0000190114 Cytochrome P450 3A Inhibitors
CHEBI has role CHEBI:76595 nephroprotective agent

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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Anuria contraindication 2472002 DOID:2983
Alcoholism contraindication 7200002
Hyperkalemia contraindication 14140009
Jaundice contraindication 18165001
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Obstruction of bile duct contraindication 30144000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypothyroidism contraindication 40930008 DOID:1459
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Azotemia contraindication 445009001
Head and Neck Angioedema contraindication
Hemodialysis with High-Flux Membrane contraindication
Severe Aortic Valve Stenosis contraindication
Intestinal Angioedema contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.0 Basic
pKa2 1.55 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 10MG BASE;14MG PRESTALIA ADHERA N205003 Jan. 21, 2015 DISCN TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 2.5MG BASE;3.5MG PRESTALIA ADHERA N205003 Jan. 21, 2015 DISCN TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 5MG BASE;7MG PRESTALIA ADHERA N205003 Jan. 21, 2015 DISCN TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 2.5MG BASE;1.25MG;20MG WIDAPLIK AZURITY N219423 June 5, 2025 DISCN TABLET ORAL 10799487 Jan. 23, 2038 A METHOD OF TREATING HYPERTENSION
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11253474 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11253474 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11253474 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11458095 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11458095 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11458095 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11723866 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11723866 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11723866 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 12005141 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 12005141 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 12005141 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 12226528 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 12226528 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 12226528 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 12440441 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 12440441 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 12440441 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 1.25MG BASE;0.625MG;10MG WIDAPLIK AZURITY N219423 June 5, 2025 DISCN TABLET ORAL June 5, 2028 NEW PRODUCT
EQ 2.5MG BASE;1.25MG;20MG WIDAPLIK AZURITY N219423 June 5, 2025 DISCN TABLET ORAL June 5, 2028 NEW PRODUCT
EQ 5MG BASE;2.5MG;40MG WIDAPLIK AZURITY N219423 June 5, 2025 DISCN TABLET ORAL June 5, 2028 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER WOMBAT-PK CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel BLOCKER Ki 7 WOMBAT-PK CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 5.63 CHEMBL
Aldehyde oxidase Enzyme IC50 5.26 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 6.58 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.36 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 5.27 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.10 CHEMBL
Voltage-dependent calcium channel gamma-1 subunit Ion channel Ki 7.20 WOMBAT-PK
Carbonic anhydrase 1 Enzyme WOMBAT-PK
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel Ki 7.20 WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 4.51 WOMBAT-PK
Potassium channel subfamily K member 2 Ion channel IC50 6.40 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 6.65 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.87 DRUG MATRIX
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 8.70 CHEMBL
Potassium channel subfamily K member 2 Ion channel IC50 6.37 CHEMBL

External reference:

IDSource
4020813 VUID
N0000148333 NUI
D00615 KEGG_DRUG
111470-99-6 SECONDARY_CAS_RN
104416 RXNORM
C0051696 UMLSCUI
CHEBI:2668 CHEBI
06X PDB_CHEM_ID
CHEMBL1491 ChEMBL_ID
CHEMBL1200402 ChEMBL_ID
CHEMBL1200984 ChEMBL_ID
D017311 MESH_DESCRIPTOR_UI
DB00381 DRUGBANK_ID
2162 PUBCHEM_CID
6981 IUPHAR_LIGAND_ID
5729 INN_ID
88150-47-4 SECONDARY_CAS_RN
246852-12-0 SECONDARY_CAS_RN
1J444QC288 UNII
108736 MMSL
173594 MMSL
23944 MMSL
27341 MMSL
4180 MMSL
d00689 MMSL
4020586 VANDF
4020813 VANDF
003672 NDDF
003673 NDDF
008599 NDDF
015579 NDDF
108537001 SNOMEDCT_US
1193663008 SNOMEDCT_US
384976003 SNOMEDCT_US
386864001 SNOMEDCT_US
421048000 SNOMEDCT_US
1J444QC288 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1520 TABLET 2.50 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1530 TABLET 5 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1540 TABLET 10 mg ORAL NDA 26 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 5 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 5 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 5 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 5 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6180 TABLET, FILM COATED 5 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6323 TABLET, FILM COATED 5 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6565 TABLET, FILM COATED 5 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6747 TABLET, FILM COATED 5 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7232 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7476 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7654 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7810 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0364 CAPSULE 10 mg ORAL NDA 29 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0379 CAPSULE 10 mg ORAL NDA 29 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0405 CAPSULE 5 mg ORAL NDA 29 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0406 CAPSULE 5 mg ORAL NDA 29 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0488 TABLET, FILM COATED 5 mg ORAL NDA 31 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0489 TABLET, FILM COATED 10 mg ORAL NDA 31 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0490 TABLET, FILM COATED 5 mg ORAL NDA 31 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0491 TABLET, FILM COATED 10 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0559 TABLET, FILM COATED 5 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0560 TABLET, FILM COATED 5 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0561 TABLET, FILM COATED 10 mg ORAL NDA 31 sections