salsalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
analgesic anti-inflammatory	2420	552-94-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: salsalate salicylic acid salicylate disalicylic acid salicyl salicylate salicyloxysalicylic acid salicyloylsalicylic acid salicylsalicylic acid sasapyrine	Molecular weight: 258.23 Formula: C14H10O5 CLOGP: 3.35 LIPINSKI: 0 HAC: 5 HDO: 2 TPSA: 83.83 ALOGS: -3.02 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

salsalate
salicylic acid salicylate
disalicylic acid
salicyl salicylate
salicyloxysalicylic acid
salicyloylsalicylic acid
salicylsalicylic acid
sasapyrine

Molecular weight: 258.23
Formula: C14H10O5
CLOGP: 3.35
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 83.83
ALOGS: -3.02
ROTB: 4

Drug dosage:

Dose	Unit	Route
3	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
International normalised ratio increased	35.96	30.46	15	376	47312	34909228

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	29.18	25.86	22	627	298894	79444845

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N02BA06	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Salicylic acid and derivatives
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:35526	antidiabetic
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:35625	beta-lactamase inhibitors
CHEBI has role	CHEBI:35842	anti-rheumatic drugs
CHEBI has role	CHEBI:50266	Prodrugs
CHEBI has role	CHEBI:35441	antiinfective agents
CHEBI has role	CHEBI:35718	antifungal agents
CHEBI has role	CHEBI:37848	plant hormones

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Rheumatoid arthritis	indication	69896004	DOID:7148
Osteoarthritis	indication	396275006
Gastritis	contraindication	4556007	DOID:4029
Gastrointestinal ulcer	contraindication	40845000
Body fluid retention	contraindication	43498006
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Hepatic failure	contraindication	59927004
Blood coagulation disorder	contraindication	64779008	DOID:1247

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.37	acidic
pKa2	9.43	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
SAL	PDB_CHEM_ID
001596	NDDF
001951	NDDF
13252002	SNOMEDCT_US
1419	MMSL
3267	INN_ID
338	PUBCHEM_CID
36108	RXNORM
387072007	SNOMEDCT_US
387253001	SNOMEDCT_US

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Salsalate	HUMAN PRESCRIPTION DRUG LABEL	1	10135-492	TABLET, FILM COATED	500 mg	ORAL	UNAPPROVED DRUG OTHER	27 sections
Salsalate	HUMAN PRESCRIPTION DRUG LABEL	1	10135-493	TABLET, FILM COATED	750 mg	ORAL	UNAPPROVED DRUG OTHER	27 sections
Salsalate	HUMAN PRESCRIPTION DRUG LABEL	1	21695-392	TABLET	750 mg	ORAL	Unapproved drug other	28 sections
Salsalate	HUMAN PRESCRIPTION DRUG LABEL	1	42192-365	TABLET	500 mg	ORAL	unapproved drug other	27 sections
Salsalate	HUMAN PRESCRIPTION DRUG LABEL	1	42192-366	TABLET	750 mg	ORAL	unapproved drug other	27 sections
Salsalate	HUMAN PRESCRIPTION DRUG LABEL	1	43063-577	TABLET	750 mg	ORAL	unapproved drug other	27 sections
SALSALATE	HUMAN PRESCRIPTION DRUG LABEL	1	43353-771	TABLET	750 mg	ORAL	Unapproved drug other	26 sections
Salsalate	HUMAN PRESCRIPTION DRUG LABEL	1	50682-507	TABLET, FILM COATED	500 mg	ORAL	Unapproved drug other	25 sections
Salsalate	HUMAN PRESCRIPTION DRUG LABEL	1	50682-508	TABLET, FILM COATED	750 mg	ORAL	Unapproved drug other	25 sections
Salsalate	HUMAN PRESCRIPTION DRUG LABEL	1	51293-615	TABLET	500 mg	ORAL	UNAPPROVED DRUG OTHER	15 sections

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