oxycodone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2029 76-42-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxycontin
  • oxycodone
  • dihydro-14-hydroxycodeinone
  • dihydrohydroxycodeinone
  • dihydrone
  • oxicon
  • oxycodeinone
  • oxymorphone 3-methyl ether
  • oxynorm
  • oxycodone hydrochloride
  • oxycodone terephthalate
  • oxycodone hydrochloride hydrate
  • oxycodone HCl
A semisynthetic derivative of CODEINE.
  • Molecular weight: 315.37
  • Formula: C18H21NO4
  • CLOGP: -0.04
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 59
  • ALOGS: -1.75
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
30 mg P
75 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 100 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 19 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.06 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 42 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.55 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 12, 1950 FDA ENDO PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1552.75 9.68 1828 255050 61580 46367604
Completed suicide 1548.75 9.68 2832 254046 143088 46286096
Drug abuser 1239.92 9.68 516 256362 2717 46426467
Drug dependence 1016.88 9.68 857 256021 19044 46410140
Toxicity to various agents 841.24 9.68 2818 254060 208948 46220236
Respiratory arrest 743.95 9.68 924 255954 32892 46396292
Inadequate analgesia 533.75 9.68 276 256602 2548 46426636
Overdose 515.26 9.68 1477 255401 100502 46328682
Drug withdrawal syndrome 441.16 9.68 643 256235 26741 46402443
Cardio-respiratory arrest 436.29 9.68 996 255882 58873 46370311
Death 304.24 9.68 2998 253880 332550 46096634
Accidental overdose 291.51 9.68 449 256429 19617 46409567
Substance abuse 280.31 9.68 211 256667 3956 46425228
Cardiac arrest 279.96 9.68 1111 255767 89288 46339896
Maternal exposure during pregnancy 261.99 9.68 118 256760 102431 46326753
Rheumatoid arthritis 240.27 9.68 611 256267 239604 46189580
Off label use 215.82 9.68 1218 255660 378623 46050561
Respiratory depression 189.12 9.68 274 256604 11326 46417858
Drug hypersensitivity 185.50 9.68 2104 254774 241721 46187463
Intentional product misuse 185.28 9.68 626 256252 46502 46382682
Constipation 182.10 9.68 1605 255273 172492 46256692
Pain 163.89 9.68 3599 253279 473349 45955835
Exposure during pregnancy 160.67 9.68 216 256662 107996 46321188
Drug ineffective 146.99 9.68 2739 254139 675099 45754085
Pemphigus 139.74 9.68 38 256840 45236 46383948
Poisoning 138.36 9.68 264 256614 13730 46415454
Drug screen positive 131.36 9.68 133 256745 3758 46425426
Delirium 128.66 9.68 474 256404 36754 46392430
Treatment failure 121.50 9.68 203 256675 92884 46336300
Abortion spontaneous 118.20 9.68 46 256832 43600 46385584
Back pain 114.30 9.68 1705 255173 208334 46220850
Accidental death 112.64 9.68 88 256790 1747 46427437
Systemic lupus erythematosus 103.05 9.68 124 256754 65056 46364128
Device expulsion 99.61 9.68 16 256862 27526 46401658
Alopecia 91.26 9.68 522 256356 161892 46267292
Malignant neoplasm progression 89.39 9.68 638 256240 64288 46364896
Injection site pain 87.73 9.68 299 256579 106853 46322331
Hyperaesthesia 87.46 9.68 156 256722 7700 46421484
Drug tolerance 87.40 9.68 98 256780 3120 46426064
Miosis 87.06 9.68 142 256736 6515 46422669
Mental status changes 86.57 9.68 427 256451 37661 46391523
Injection site erythema 84.99 9.68 176 256702 74251 46354933
Cough 84.99 9.68 833 256045 229416 46199768
Somnolence 79.08 9.68 1255 255623 155266 46273918
Respiratory rate decreased 78.19 9.68 91 256787 3019 46426165
Product complaint 76.89 9.68 191 256687 11910 46417274
Unresponsive to stimuli 76.21 9.68 365 256513 31809 46397375
Injection site reaction 73.56 9.68 93 256785 47756 46381428
Muscle spasticity 72.10 9.68 180 256698 11260 46417924
Exposure via ingestion 71.83 9.68 92 256786 3375 46425809
Injection site swelling 70.03 9.68 71 256807 40256 46388928
Withdrawal syndrome 69.59 9.68 239 256639 17895 46411289
Muscle injury 68.02 9.68 107 256771 4759 46424425
Plasma cell myeloma 65.88 9.68 445 256433 44033 46385151
Cardiac failure 65.49 9.68 223 256655 79725 46349459
Asthma 64.82 9.68 271 256607 91271 46337913
Vomiting 64.67 9.68 3077 253801 449717 45979467
Confusional state 62.20 9.68 1230 255648 158662 46270522
Product use in unapproved indication 58.62 9.68 276 256602 89997 46339187
Glossodynia 57.66 9.68 97 256781 44276 46384908
Night sweats 57.36 9.68 299 256579 26951 46402233
Drug reaction with eosinophilia and systemic symptoms 57.28 9.68 47 256831 29501 46399683
Folliculitis 55.23 9.68 112 256766 6091 46423093
Drug resistance 54.69 9.68 14 256864 17354 46411830
Cytomegalovirus infection 54.55 9.68 16 256862 18128 46411056
Hand deformity 54.40 9.68 66 256812 34508 46394676
Soft tissue disorder 54.35 9.68 89 256789 4097 46425087
Product use issue 54.30 9.68 302 256576 94342 46334842
Presbyacusis 53.99 9.68 72 256806 2750 46426434
Psoriasis 53.62 9.68 236 256642 78368 46350816
Pleural fibrosis 53.42 9.68 81 256797 3488 46425696
Condition aggravated 52.76 9.68 990 255888 244062 46185122
Foetal exposure during pregnancy 52.40 9.68 55 256823 30692 46398492
Drug intolerance 52.12 9.68 537 256341 146512 46282672
Red blood cell sedimentation rate abnormal 51.50 9.68 7 256871 13642 46415542
Drug interaction 51.31 9.68 797 256081 202297 46226887
Nausea 50.79 9.68 4414 252464 683040 45746144
Fibromyalgia 50.57 9.68 359 256519 36104 46393080
Delusional disorder, unspecified type 50.09 9.68 30 256848 377 46428807
Dependence 49.38 9.68 57 256821 1874 46427310
Pleural thickening 49.32 9.68 66 256812 2529 46426655
Cancer pain 49.17 9.68 64 256814 2386 46426798
Injury 49.10 9.68 412 256466 43615 46385569
Blood magnesium increased 48.61 9.68 71 256807 2956 46426228
Lactic acidosis 47.98 9.68 70 256808 33839 46395345
Contraindicated product administered 47.57 9.68 252 256626 79695 46349489
Cholecystitis chronic 47.15 9.68 146 256732 10353 46418831
Medication error 45.02 9.68 308 256570 30603 46398581
Premature delivery 44.16 9.68 34 256844 22035 46407149
Drug screen negative 43.97 9.68 27 256851 356 46428828
Body temperature increased 43.80 9.68 260 256618 24601 46404583
Deafness neurosensory 43.46 9.68 84 256794 4410 46424774
Toxic leukoencephalopathy 41.70 9.68 30 256848 523 46428661
Epilepsy 40.98 9.68 42 256836 23696 46405488
Nasal necrosis 40.76 9.68 17 256861 90 46429094
Product formulation issue 40.59 9.68 32 256846 644 46428540
Depressed level of consciousness 39.94 9.68 419 256459 47150 46382034
Drug diversion 39.73 9.68 35 256843 826 46428358
Infusion related reaction 39.04 9.68 362 256516 100846 46328338
No adverse event 39.02 9.68 81 256797 34150 46395034
Injection site pruritus 38.92 9.68 102 256776 39641 46389543
Hypertension 38.68 9.68 805 256073 195551 46233633
Abdominal discomfort 38.57 9.68 592 256286 150573 46278611
Disease progression 38.42 9.68 711 256167 90589 46338595
Anxiety 37.30 9.68 1286 255592 180671 46248513
Road traffic accident 36.87 9.68 240 256638 23451 46405733
Velopharyngeal incompetence 36.81 9.68 12 256866 26 46429158
Acute lung injury 36.75 9.68 40 256838 1231 46427953
Sleep disorder due to general medical condition, insomnia type 36.73 9.68 86 256792 5163 46424021
Anaphylactic reaction 36.49 9.68 159 256719 52953 46376231
Circulatory collapse 36.49 9.68 39 256839 21585 46407599
Spinal operation 35.79 9.68 88 256790 5452 46423732
Bone cyst 35.72 9.68 50 256828 2001 46427183
Live birth 35.18 9.68 7 256871 10323 46418861
Irritable bowel syndrome 34.61 9.68 181 256697 16334 46412850
Narcotic bowel syndrome 34.21 9.68 16 256862 116 46429068
Ear pain 33.89 9.68 223 256655 21869 46407315
Lethargy 33.69 9.68 430 256448 50741 46378443
Premature baby 33.65 9.68 30 256848 18082 46411102
Atrial fibrillation 33.21 9.68 387 256491 103203 46325981
Drug detoxification 32.91 9.68 18 256860 188 46428996
Spinal cord ischaemia 32.80 9.68 11 256867 27 46429157
Hypoxia 32.61 9.68 432 256446 51406 46377778
Emotional distress 32.47 9.68 284 256594 30423 46398761
Osteosclerosis 31.92 9.68 64 256814 3452 46425732
Oesophageal motility disorder 31.79 9.68 20 256858 276 46428908
Anti-cyclic citrullinated peptide antibody positive 31.79 9.68 35 256843 19110 46410074
Toxicologic test abnormal 31.43 9.68 28 256850 671 46428513
Angioedema 31.35 9.68 111 256767 39231 46389953
Bone erosion 30.93 9.68 7 256871 9436 46419748
Decorticate posture 30.56 9.68 21 256857 339 46428845
Neuralgia 30.51 9.68 212 256666 21171 46408013
Myocardial depression 30.40 9.68 24 256854 484 46428700
Epigastric discomfort 30.27 9.68 84 256794 5600 46423584
Accidental exposure to product by child 30.16 9.68 34 256844 1089 46428095
Deep vein thrombosis 29.75 9.68 610 256268 79163 46350021
Hypersensitivity 29.67 9.68 616 256262 149705 46279479
Pregnancy 29.45 9.68 66 256812 27071 46402113
Foetal megacystis 29.42 9.68 10 256868 26 46429158
Tooth loss 29.23 9.68 92 256786 6581 46422603
Pulmonary embolism 28.78 9.68 792 256086 107793 46321391
Status epilepticus 28.66 9.68 21 256857 13958 46415226
Sedation 28.59 9.68 220 256658 22690 46406494
Bradypnoea 28.41 9.68 56 256822 2983 46426201
Hepatic enzyme increased 28.41 9.68 300 256578 81487 46347697
Compartment syndrome 28.00 9.68 44 256834 1955 46427229
Headache 27.90 9.68 2260 254618 476092 45953092
Hepatitis 27.65 9.68 88 256790 32127 46397057
Therapeutic product effect incomplete 27.42 9.68 286 256592 77867 46351317
Hyponatraemia 27.16 9.68 393 256485 100939 46328245
Small intestinal obstruction 27.13 9.68 167 256711 16005 46413179
Injection site bruising 26.79 9.68 103 256775 35533 46393651
Dyspnoea 26.62 9.68 2459 254419 513089 45916095
Cataract 26.54 9.68 144 256734 45271 46383913
Depression 26.31 9.68 1166 255712 168938 46260246
Pneumocystis jirovecii pneumonia 26.29 9.68 27 256851 15221 46413963
Breakthrough pain 26.15 9.68 32 256846 1120 46428064
Victim of homicide 26.11 9.68 11 256867 60 46429124
Palpitations 26.03 9.68 368 256510 94891 46334293
Abortion induced 25.88 9.68 12 256866 10248 46418936
Neoplasm malignant 25.72 9.68 219 256659 23280 46405904
Anaphylactic shock 25.71 9.68 45 256833 20229 46408955
Back disorder 25.61 9.68 109 256769 9032 46420152
Syncope 25.52 9.68 414 256464 104389 46324795
Dizziness 25.43 9.68 1574 255304 338840 46090344
Chest discomfort 25.28 9.68 347 256531 89922 46339262
Electrocardiogram U-wave abnormality 25.28 9.68 10 256868 45 46429139
Hyperhidrosis 25.27 9.68 657 256221 88651 46340533
Ulcer 25.14 9.68 173 256705 17219 46411965
Spinal fracture 25.02 9.68 157 256721 15148 46414036
Accidental poisoning 24.79 9.68 23 256855 582 46428602
Arrhythmia 24.73 9.68 103 256775 34738 46394446
Hypoglycaemia 24.27 9.68 187 256691 54162 46375022
Lip swelling 24.24 9.68 66 256812 25329 46403855
C-reactive protein increased 24.15 9.68 206 256672 58384 46370800
Erythema 24.01 9.68 600 256278 142220 46286964
Haemophagocytic lymphohistiocytosis 23.93 9.68 8 256870 8334 46420850
Peripheral swelling 23.89 9.68 1081 255797 156990 46272194
Intervertebral disc protrusion 23.85 9.68 193 256685 20212 46408972
Atelectasis 23.76 9.68 181 256697 18609 46410575
Serotonin syndrome 23.56 9.68 220 256658 24000 46405184
Metastases to bone 23.04 9.68 170 256708 17306 46411878
Transplant rejection 23.02 9.68 12 256866 9584 46419600
Stillbirth 22.96 9.68 4 256874 6487 46422697
Pulmonary arterial hypertension 22.83 9.68 70 256808 25858 46403326
Cardiac failure congestive 22.81 9.68 361 256517 91389 46337795
Caesarean section 22.78 9.68 35 256843 16568 46412616
Stevens-Johnson syndrome 22.65 9.68 60 256818 23237 46405947
Intraocular pressure increased 22.61 9.68 3 256875 5954 46423230
Poisoning deliberate 22.58 9.68 95 256783 7831 46421353
Allodynia 22.55 9.68 21 256857 534 46428650
Learning disability 22.40 9.68 11 256867 90 46429094
Eosinophilia 22.30 9.68 45 256833 19172 46410012
Spinal cord infarction 22.19 9.68 16 256862 280 46428904
Oesophageal achalasia 22.08 9.68 17 256861 330 46428854
Tenosynovitis stenosans 22.08 9.68 39 256839 1910 46427274
Aplastic anaemia 22.07 9.68 6 256872 7147 46422037
Hypersomnia 21.98 9.68 153 256725 15286 46413898
Vertigo 21.90 9.68 182 256696 51866 46377318
Brain injury 21.82 9.68 79 256799 6071 46423113
Synovial fluid analysis 21.64 9.68 32 256846 1347 46427837
Paranoia 21.42 9.68 115 256763 10482 46418702
Impaired reasoning 21.37 9.68 9 256869 49 46429135
Gun shot wound 21.32 9.68 11 256867 101 46429083
Sickle cell anaemia with crisis 21.27 9.68 59 256819 3933 46425251
Diffuse cutaneous mastocytosis 21.04 9.68 5 256873 0 46429184
Abdominal pain 20.91 9.68 1502 255376 228529 46200655
Therapeutic product effect increased 20.82 9.68 27 256851 1003 46428181
Multiple organ dysfunction syndrome 20.78 9.68 183 256695 51527 46377657
Pericarditis 20.09 9.68 66 256812 23861 46405323
Insomnia 19.97 9.68 1104 255774 163820 46265364
Flank pain 19.97 9.68 123 256755 11790 46417394
Injection site warmth 19.91 9.68 28 256850 13744 46415440
Tenderness 19.91 9.68 160 256718 16721 46412463
Faecaloma 19.86 9.68 90 256788 7662 46421522
Toxic epidermal necrolysis 19.72 9.68 60 256818 22218 46406966
Bradycardia 19.60 9.68 252 256626 66046 46363138
Epistaxis 19.54 9.68 243 256635 64062 46365122
Respiratory disorder 19.51 9.68 233 256645 27067 46402117
Cervix neoplasm 19.34 9.68 13 256865 202 46428982
Stomatitis 19.19 9.68 502 256376 67795 46361389
Encephalopathy 19.12 9.68 275 256603 33314 46395870
Failure to thrive 19.08 9.68 80 256798 6584 46422600
Uveitis 19.03 9.68 12 256866 8629 46420555
Unintended pregnancy 18.94 9.68 4 256874 5656 46423528
Gallbladder disorder 18.58 9.68 162 256716 17336 46411848
Salpingo-oophorectomy unilateral 18.51 9.68 16 256862 368 46428816
Product residue present 18.38 9.68 55 256823 3827 46425357
Premature labour 18.38 9.68 21 256857 11278 46417906
Cerebral haemorrhage 18.25 9.68 87 256791 28284 46400900
Femur fracture 18.11 9.68 124 256754 36873 46392311
Malaise 18.04 9.68 1573 255305 329659 46099525
Clear cell renal cell carcinoma 17.98 9.68 25 256853 994 46428190
Electrocardiogram QT prolonged 17.92 9.68 188 256690 51137 46378047
Euphoric mood 17.89 9.68 58 256820 4214 46424970
Spleen congestion 17.72 9.68 11 256867 148 46429036
Rash pustular 17.64 9.68 8 256870 6921 46422263
Productive cough 17.62 9.68 186 256692 50529 46378655
Dehydration 17.59 9.68 1059 255819 158481 46270703
Complication of device insertion 17.59 9.68 3 256875 4941 46424243
Pleuritic pain 17.58 9.68 76 256802 6340 46422844
Injection site haemorrhage 17.47 9.68 57 256821 20652 46408532
Gestational diabetes 17.36 9.68 9 256869 7210 46421974
Type 2 diabetes mellitus 17.26 9.68 54 256824 19821 46409363
Medication overuse headache 17.24 9.68 17 256861 465 46428719
Thrombosis 17.19 9.68 417 256461 55652 46373532
Discomfort 17.10 9.68 169 256709 46501 46382683
Coma 17.01 9.68 431 256447 57918 46371266
Rash 17.00 9.68 1710 255168 354802 46074382
Lower respiratory tract infection 16.98 9.68 410 256468 54679 46374505
Osteopenia 16.97 9.68 155 256723 16806 46412378
Myoclonus 16.91 9.68 136 256742 14216 46414968
Paranoid personality disorder 16.83 9.68 4 256874 0 46429184
Lung cancer metastatic 16.79 9.68 40 256838 2428 46426756
Anoxia 16.73 9.68 13 256865 256 46428928
Hallucination 16.70 9.68 376 256502 49575 46379609
Seizure 16.59 9.68 533 256345 122521 46306663
Therapeutic response unexpected 16.29 9.68 144 256734 15472 46413712
Drug withdrawal syndrome neonatal 16.21 9.68 34 256844 1894 46427290
Myopathy 16.15 9.68 15 256863 8866 46420318
Agranulocytosis 16.11 9.68 65 256813 22120 46407064
Stress cardiomyopathy 16.09 9.68 85 256793 7699 46421485
Diabetes mellitus 16.05 9.68 187 256691 49878 46379306
Synovitis 15.96 9.68 238 256640 60837 46368347
Performance enhancing product use 15.94 9.68 5 256873 9 46429175
Judgement impaired 15.91 9.68 19 256859 648 46428536
Mandibular mass 15.88 9.68 11 256867 180 46429004
Drug tolerance increased 15.83 9.68 10 256868 139 46429045
Immunodeficiency 15.81 9.68 30 256848 13076 46416108
Tuberculosis 15.72 9.68 20 256858 10245 46418939
Coeliac disease 15.69 9.68 10 256868 7151 46422033
Acute myocardial infarction 15.62 9.68 107 256771 31817 46397367
Infective pulmonary exacerbation of cystic fibrosis 15.59 9.68 22 256856 10785 46418399
Immune reconstitution inflammatory syndrome 15.55 9.68 6 256872 5719 46423465
Influenza 15.55 9.68 373 256505 88897 46340287
Colitis ulcerative 15.52 9.68 48 256830 17684 46411500
Glaucoma 15.48 9.68 41 256837 15880 46413304
Injection site induration 15.47 9.68 13 256865 8066 46421118
Viral infection 15.47 9.68 100 256778 30135 46399049
Respiratory acidosis 15.47 9.68 71 256807 6077 46423107
Myalgia 15.45 9.68 538 256340 122550 46306634
Impaired healing 15.39 9.68 286 256592 36457 46392727
Sphincter of Oddi dysfunction 15.36 9.68 14 256864 346 46428838
Hepatotoxicity 15.33 9.68 78 256800 24931 46404253
Oral pain 15.32 9.68 206 256672 24591 46404593
Acute kidney injury 15.31 9.68 1104 255774 234751 46194433
Cardiotoxicity 15.27 9.68 9 256869 6713 46422471
Myocardial infarction 15.25 9.68 414 256464 97114 46332070
Myelosuppression 15.24 9.68 12 256866 7691 46421493
Radiculopathy 15.19 9.68 61 256817 4924 46424260
Melaena 15.17 9.68 90 256788 27682 46401502
Therapeutic response decreased 15.08 9.68 158 256720 42987 46386197
Dermatitis allergic 15.07 9.68 29 256849 12574 46416610
Jaundice 14.97 9.68 95 256783 28750 46400434
Pneumonia viral 14.86 9.68 74 256804 6550 46422634
Ileus 14.83 9.68 130 256748 13934 46415250
Central nervous system stimulation 14.83 9.68 6 256872 29 46429155
Splenic injury 14.71 9.68 11 256867 204 46428980
Sinusitis fungal 14.69 9.68 21 256857 857 46428327
Intestinal obstruction 14.65 9.68 213 256665 25862 46403322
Foetal growth restriction 14.63 9.68 9 256869 6558 46422626
Red blood cell sedimentation rate 14.60 9.68 31 256847 1742 46427442
Plasmacytoma 14.60 9.68 38 256840 2439 46426745
Lupus-like syndrome 14.56 9.68 13 256865 7831 46421353
Cerebrovascular accident 14.50 9.68 434 256444 100605 46328579
Female genital tract fistula 14.50 9.68 45 256833 3194 46425990
Blood potassium decreased 14.49 9.68 292 256586 37771 46391413
Snake bite 14.44 9.68 5 256873 14 46429170
Cyst 14.44 9.68 115 256763 11985 46417199
Gastrointestinal haemorrhage 14.40 9.68 320 256558 77053 46352131
Non-small cell lung cancer 14.38 9.68 44 256834 3100 46426084
Opiates positive 14.36 9.68 12 256866 263 46428921
Agitation 14.34 9.68 403 256475 55012 46374172
Blister 14.31 9.68 334 256544 44297 46384887
Overwork 14.28 9.68 7 256871 57 46429127
Dental caries 14.28 9.68 102 256776 10277 46418907
Spinal fusion surgery 14.20 9.68 42 256836 2904 46426280
Drug use disorder 14.15 9.68 40 256838 2695 46426489
Myelodysplastic syndrome 14.13 9.68 42 256836 15669 46413515
Uterine perforation 14.11 9.68 78 256800 7189 46421995
Foreign body embolism 14.08 9.68 4 256874 4 46429180
Wound 14.06 9.68 159 256719 42643 46386541
Blood pressure increased 14.04 9.68 562 256316 126104 46303080
Oesophageal obstruction 14.02 9.68 14 256864 389 46428795
Angina pectoris 13.98 9.68 88 256790 26687 46402497
Dermatitis exfoliative 13.93 9.68 7 256871 5709 46423475
Cardiogenic shock 13.89 9.68 45 256833 16339 46412845
Nerve injury 13.84 9.68 81 256797 7624 46421560
Obsessive-compulsive disorder 13.78 9.68 44 256834 3171 46426013
Ischaemic hepatitis 13.68 9.68 33 256845 2020 46427164
Proteinuria 13.66 9.68 46 256832 16507 46412677
Complex regional pain syndrome 13.54 9.68 33 256845 2033 46427151
Spinal cord injury 13.48 9.68 16 256862 542 46428642
Hypercalcaemia 13.48 9.68 176 256702 20870 46408314
Food allergy 13.47 9.68 11 256867 6922 46422262
Acne 13.46 9.68 60 256818 19859 46409325
Hepatocellular injury 13.45 9.68 101 256777 29421 46399763
Nasal congestion 13.45 9.68 185 256693 47928 46381256
Ischaemic stroke 13.44 9.68 47 256831 16675 46412509
Post laminectomy syndrome 13.44 9.68 11 256867 234 46428950
Ear infection 13.42 9.68 73 256805 22940 46406244
Bronchiectasis 13.40 9.68 19 256859 9297 46419887
Swollen tongue 13.32 9.68 100 256778 29132 46400052
Bone marrow failure 13.28 9.68 102 256776 29567 46399617
Colitis microscopic 13.25 9.68 10 256868 6546 46422638
Enthesopathy 13.19 9.68 56 256822 4634 46424550
Ventricular septal defect 13.19 9.68 3 256875 4031 46425153
Oropharyngeal pain 13.16 9.68 309 256569 73859 46355325
Neutropenia 13.08 9.68 649 256229 142555 46286629
Exostosis 13.05 9.68 99 256779 10164 46419020
Abdominal pain upper 13.05 9.68 948 255930 144357 46284827
Skin plaque 12.99 9.68 8 256870 5827 46423357
Cardiovascular disorder 12.93 9.68 30 256848 12157 46417027
Deformity 12.85 9.68 76 256802 7181 46422003
Forced expiratory volume decreased 12.82 9.68 6 256872 5098 46424086
Low birth weight baby 12.74 9.68 7 256871 5427 46423757
Dermatitis bullous 12.66 9.68 14 256864 7629 46421555
Suspected suicide 12.61 9.68 55 256823 4606 46424578
Extrapyramidal disorder 12.56 9.68 27 256851 11241 46417943
Neck surgery 12.49 9.68 26 256852 1441 46427743
Presyncope 12.45 9.68 81 256797 24373 46404811
Nystagmus 12.43 9.68 8 256870 5691 46423493
Injection site rash 12.34 9.68 45 256833 15768 46413416
Spinal disorder 12.31 9.68 81 256797 7943 46421241
Musculoskeletal chest pain 12.27 9.68 153 256725 17953 46411231
Haematotoxicity 12.27 9.68 12 256866 6921 46422263
Hypophagia 12.24 9.68 228 256650 29078 46400106
Eyelid oedema 12.23 9.68 24 256854 10333 46418851
Spinal nerve stimulator implantation 12.11 9.68 7 256871 82 46429102
Flushing 12.09 9.68 267 256611 64347 46364837
Bladder injury 12.06 9.68 5 256873 26 46429158
Granulocytopenia 12.06 9.68 7 256871 5266 46423918
Diastolic hypotension 12.04 9.68 7 256871 83 46429101
Rheumatoid nodule 12.03 9.68 88 256790 8932 46420252
Adverse event 12.02 9.68 125 256753 34059 46395125
Progressive multifocal leukoencephalopathy 11.98 9.68 28 256850 11318 46417866
Inappropriate antidiuretic hormone secretion 11.77 9.68 39 256839 14063 46415121
Breathing-related sleep disorder 11.75 9.68 7 256871 87 46429097
Hypercholesterolaemia 11.74 9.68 29 256849 11501 46417683
Feeling jittery 11.73 9.68 102 256776 10906 46418278
Epstein-Barr virus infection 11.71 9.68 12 256866 6772 46422412
Maternal drugs affecting foetus 11.69 9.68 8 256870 5510 46423674
Fungal oesophagitis 11.65 9.68 15 256863 553 46428631
Feeling hot 11.64 9.68 143 256735 37785 46391399
Injection site mass 11.61 9.68 43 256835 14997 46414187
Gamma-glutamyltransferase increased 11.60 9.68 115 256763 31625 46397559
Injection site urticaria 11.50 9.68 31 256847 11936 46417248
Bedridden 11.45 9.68 88 256790 9071 46420113
Mobility decreased 11.44 9.68 250 256628 60344 46368840
Compression fracture 11.38 9.68 66 256812 6191 46422993
Smear cervix abnormal 11.31 9.68 35 256843 2481 46426703
Stool analysis abnormal 11.28 9.68 6 256872 59 46429125
Coronary artery disease 11.23 9.68 125 256753 33627 46395557
Peritonitis bacterial 11.16 9.68 19 256859 8634 46420550
Rash erythematous 11.12 9.68 128 256750 34222 46394962
Septic pulmonary embolism 11.08 9.68 5 256873 33 46429151
Demyelination 11.05 9.68 9 256869 5671 46423513
Rhinorrhoea 11.03 9.68 190 256688 47475 46381709
Surgery 11.02 9.68 221 256657 28564 46400620
Aspergillus infection 11.00 9.68 13 256865 6877 46422307
Gastroenteritis 10.97 9.68 83 256795 24136 46405048
Leukopenia neonatal 10.96 9.68 5 256873 34 46429150
Formication 10.95 9.68 47 256831 3909 46425275
Neoplasm progression 10.94 9.68 207 256671 26476 46402708
Blood potassium increased 10.92 9.68 142 256736 16825 46412359
Septic shock 10.89 9.68 239 256639 57654 46371530
Throat irritation 10.86 9.68 104 256774 28797 46400387
Wheezing 10.74 9.68 218 256660 53168 46376016
Vasculitis 10.71 9.68 39 256839 13672 46415512
Central nervous system injury 10.63 9.68 8 256870 150 46429034
Pelvic pain 10.60 9.68 104 256774 11498 46417686
Eye pruritus 10.56 9.68 32 256846 11866 46417318
Periorbital abscess 10.56 9.68 3 256875 3 46429181
Sitting disability 10.56 9.68 3 256875 3 46429181
Spinal cord operation 10.56 9.68 3 256875 3 46429181
Congenital diaphragmatic eventration 10.48 9.68 4 256874 16 46429168
Endometriosis 10.47 9.68 46 256832 3864 46425320
Wrong technique in product usage process 10.43 9.68 224 256654 54198 46374986
Intentional self-injury 10.39 9.68 84 256794 24082 46405102
Haemoptysis 10.38 9.68 93 256785 26096 46403088
Interstitial lung disease 10.36 9.68 222 256656 53727 46375457
Secretion discharge 10.35 9.68 22 256856 9197 46419987
Blood creatine phosphokinase MB increased 10.33 9.68 22 256856 1239 46427945
Decreased appetite 10.33 9.68 1218 255660 192618 46236566
Needle issue 10.33 9.68 10 256868 5794 46423390
Neuropathy peripheral 10.32 9.68 605 256273 90288 46338896
Substance use disorder 10.28 9.68 5 256873 40 46429144
Hypothalamic pituitary adrenal axis suppression 10.27 9.68 8 256870 158 46429026
Inflammatory marker increased 10.25 9.68 9 256869 5466 46423718
Malignant melanoma 10.22 9.68 26 256852 10208 46418976
Soft tissue swelling 10.21 9.68 18 256860 880 46428304
Haemorrhage 10.18 9.68 227 256651 54642 46374542
Amenorrhoea 10.18 9.68 21 256857 8874 46420310
Pyometra 10.08 9.68 7 256871 115 46429069
Spinal cord paralysis 10.07 9.68 5 256873 42 46429142
Injection site discolouration 10.04 9.68 14 256864 6896 46422288
Renal mass 10.00 9.68 27 256851 1771 46427413
Scleritis 9.99 9.68 37 256841 2875 46426309
Consciousness fluctuating 9.99 9.68 14 256864 561 46428623
Renal failure 9.95 9.68 517 256361 113077 46316107
Mental disorder 9.90 9.68 176 256702 22249 46406935
Metastases to spine 9.90 9.68 35 256843 2659 46426525
Febrile bone marrow aplasia 9.87 9.68 14 256864 6848 46422336
Shock 9.83 9.68 75 256803 21770 46407414
Immune thrombocytopenia 9.82 9.68 19 256859 8222 46420962
Hypomania 9.79 9.68 6 256872 4382 46424802
Rash maculo-papular 9.77 9.68 102 256776 27772 46401412
Parkinsonism 9.75 9.68 18 256860 7930 46421254
Hospice care 9.73 9.68 56 256822 5239 46423945
Acute graft versus host disease 9.73 9.68 5 256873 4025 46425159
Foetal death 9.70 9.68 21 256857 8722 46420462
Pulmonary granuloma 9.69 9.68 22 256856 1294 46427890

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2114.47 10.60 2603 187753 79469 29682653
Drug abuser 2000.05 10.60 826 189530 3575 29758547
Drug dependence 1559.29 10.60 1201 189155 20094 29742028
Respiratory arrest 773.91 10.60 942 189414 28316 29733806
Toxicity to various agents 740.72 10.60 2639 187717 174544 29587578
Drug withdrawal syndrome 722.57 10.60 754 189602 19055 29743067
Accidental overdose 679.83 10.60 703 189653 17572 29744550
Overdose 651.81 10.60 1566 188790 82771 29679351
Completed suicide 633.64 10.60 1717 188639 97775 29664347
Substance abuse 585.91 10.60 429 189927 6611 29755511
Inadequate analgesia 546.48 10.60 290 190066 2418 29759704
Intentional product misuse 311.78 10.60 684 189672 33983 29728139
Pain 297.73 10.60 1996 188360 170645 29591477
Cardio-respiratory arrest 230.15 10.60 844 189512 56462 29705660
Constipation 219.30 10.60 1346 189010 111560 29650562
Malignant neoplasm progression 218.05 10.60 974 189382 71313 29690809
Poisoning 200.64 10.60 301 190055 11081 29751041
Respiratory depression 199.64 10.60 302 190054 11201 29750921
Delirium 193.17 10.60 633 189723 39998 29722124
Cardiac arrest 181.51 10.60 1109 189247 91741 29670381
Off label use 170.95 10.60 910 189446 248380 29513742
Nausea 153.80 10.60 2694 187662 294263 29467859
Miosis 150.61 10.60 215 190141 7561 29754561
Drug screen positive 150.38 10.60 162 190194 4245 29757877
Drug tolerance 143.10 10.60 115 190241 2047 29760075
Accidental death 142.76 10.60 113 190243 1966 29760156
Somnolence 136.47 10.60 1067 189289 95696 29666426
Death 135.74 10.60 3094 187262 354189 29407933
Gun shot wound 125.30 10.60 84 190272 1114 29761008
Toxic leukoencephalopathy 124.98 10.60 49 190307 179 29761943
Cardiac failure 110.00 10.60 228 190128 83190 29678932
Unresponsive to stimuli 105.03 10.60 388 189968 26031 29736091
Product use in unapproved indication 104.44 10.60 193 190163 73500 29688622
Mental status changes 100.89 10.60 485 189871 36594 29725528
Foetal exposure during pregnancy 96.83 10.60 57 190299 36814 29725308
Back pain 96.59 10.60 1037 189319 101559 29660563
Drug interaction 94.76 10.60 812 189544 198756 29563366
Cytomegalovirus infection 92.19 10.60 19 190337 23655 29738467
C-reactive protein abnormal 88.87 10.60 141 190215 5452 29756670
Coma 83.30 10.60 490 189866 39959 29722163
Exposure via ingestion 82.18 10.60 92 190264 2519 29759603
Drug resistance 80.83 10.60 15 190341 20118 29742004
Sedation 78.58 10.60 256 190100 16117 29746005
Hyperaesthesia 78.51 10.60 105 190251 3468 29758654
Narcotic bowel syndrome 76.23 10.60 30 190326 111 29762011
Acute kidney injury 75.98 10.60 1254 189102 272588 29489534
Drug reaction with eosinophilia and systemic symptoms 73.45 10.60 45 190311 28443 29733679
Cancer pain 68.42 10.60 82 190274 2420 29759702
Epilepsy 65.70 10.60 23 190333 20146 29741976
Paroxysmal sympathetic hyperactivity 65.04 10.60 16 190340 0 29762122
Withdrawal syndrome 63.37 10.60 186 190170 11064 29751058
Leukopenia 63.17 10.60 167 190189 55992 29706130
Vomiting 59.68 10.60 1823 188533 217995 29544127
Bradycardia 59.41 10.60 215 190141 65311 29696811
Lactic acidosis 58.69 10.60 67 190289 31146 29730976
Asthma 58.41 10.60 87 190269 36087 29726035
Breakthrough pain 58.26 10.60 40 190316 553 29761569
Road traffic accident 57.51 10.60 238 190118 16833 29745289
Plasma cell myeloma 57.23 10.60 555 189801 52907 29709215
Angioedema 57.18 10.60 81 190275 34303 29727819
Dependence 56.41 10.60 53 190303 1173 29760949
Confusional state 53.75 10.60 1177 189179 133657 29628465
Hyperhidrosis 53.15 10.60 656 189700 66434 29695688
Foreign body reaction 52.52 10.60 19 190337 52 29762070
Drug hypersensitivity 52.15 10.60 665 189691 67854 29694268
Enthesopathy 51.41 10.60 77 190279 2829 29759293
Respiratory rate decreased 50.48 10.60 60 190296 1755 29760367
Cardiogenic shock 50.34 10.60 22 190334 16839 29745283
Toxic epidermal necrolysis 49.60 10.60 26 190330 17914 29744208
Psoriasis 48.87 10.60 125 190231 42381 29719741
Toxicologic test abnormal 47.95 10.60 36 190320 577 29761545
Cerebral haemorrhage 47.57 10.60 85 190271 32802 29729320
Anxiety 47.50 10.60 819 189537 89052 29673070
Eosinophilia 46.84 10.60 43 190313 22117 29740005
Drug ineffective 46.66 10.60 1732 188624 338655 29423467
Neutropenia 46.39 10.60 558 189798 127982 29634140
Drug use disorder 46.34 10.60 78 190278 3170 29758952
Cough 45.89 10.60 544 189812 125098 29637024
Myocardial infarction 45.85 10.60 544 189812 125081 29637041
Renal impairment 45.67 10.60 330 190026 83854 29678268
Seizure 45.59 10.60 403 189953 98072 29664050
Neuroleptic malignant syndrome 44.49 10.60 24 190332 16271 29745851
Hypoglycaemia 44.42 10.60 170 190186 50811 29711311
Drug tolerance increased 44.34 10.60 29 190327 368 29761754
Melaena 44.13 10.60 87 190269 32350 29729772
Product complaint 43.83 10.60 107 190249 5699 29756423
Delusional disorder, unspecified type 43.77 10.60 38 190318 756 29761366
Agranulocytosis 43.58 10.60 45 190311 21897 29740225
Disease progression 42.24 10.60 728 189628 79146 29682976
Depression 42.12 10.60 808 189548 89629 29672493
Acute myocardial infarction 42.07 10.60 183 190173 52756 29709366
Terminal state 41.72 10.60 79 190277 3525 29758597
Lethargy 39.73 10.60 405 189951 39114 29723008
Cardiac failure congestive 39.69 10.60 344 190012 84063 29678059
Drug diversion 39.11 10.60 38 190318 878 29761244
Thrombosis 38.81 10.60 425 189931 41806 29720316
Pulmonary thrombosis 38.76 10.60 108 190248 6235 29755887
Thrombocytopenia 38.71 10.60 625 189731 136419 29625703
Spinal fracture 38.41 10.60 112 190244 6636 29755486
Product use issue 37.83 10.60 157 190199 45859 29716263
Toxic skin eruption 36.85 10.60 12 190344 11003 29751119
Incorrect route of product administration 36.74 10.60 156 190200 11159 29750963
Intervertebral disc degeneration 36.73 10.60 94 190262 5157 29756965
Atrial fibrillation 36.51 10.60 476 189880 107648 29654474
Syncope 36.46 10.60 354 190002 84549 29677573
Angina pectoris 36.13 10.60 84 190272 29434 29732688
Tenosynovitis 35.79 10.60 73 190283 3442 29758680
Schizophrenia 35.77 10.60 7 190349 9041 29753081
Accident 35.57 10.60 74 190282 3539 29758583
Bone pain 35.05 10.60 224 190132 18802 29743320
Neoplasm progression 34.95 10.60 215 190141 17808 29744314
Drug eruption 34.74 10.60 36 190320 17490 29744632
Decreased appetite 33.61 10.60 1216 189140 148694 29613428
Depressed level of consciousness 33.45 10.60 381 189975 37841 29724281
Condition aggravated 32.83 10.60 648 189708 137218 29624904
Cerebrovascular accident 32.58 10.60 356 190000 83121 29679001
Pathogen resistance 32.22 10.60 7 190349 8403 29753719
Immune reconstitution inflammatory syndrome 32.10 10.60 9 190347 9092 29753030
Epstein-Barr virus infection 31.66 10.60 3 190353 6703 29755419
Substance dependence 31.59 10.60 24 190332 392 29761730
Impaired driving ability 31.41 10.60 57 190299 2461 29759661
Bradypnoea 31.31 10.60 49 190307 1872 29760250
Compartment syndrome 31.27 10.60 57 190299 2470 29759652
Proteinuria 31.06 10.60 34 190322 16111 29746011
Apparent death 30.81 10.60 69 190287 3473 29758649
Piloerection 30.65 10.60 17 190339 156 29761966
Gastrointestinal haemorrhage 29.79 10.60 363 189993 83083 29679039
Labelled drug-drug interaction medication error 29.54 10.60 15 190341 10523 29751599
Circulatory collapse 29.45 10.60 52 190304 20162 29741960
Compression fracture 29.45 10.60 61 190295 2908 29759214
Aspergillus infection 29.44 10.60 14 190342 10200 29751922
Neoplasm malignant 29.36 10.60 204 190152 17610 29744512
Apnoea 29.26 10.60 97 190259 6161 29755961
Transplant rejection 29.13 10.60 11 190345 9195 29752927
Hepatotoxicity 28.94 10.60 44 190312 18101 29744021
Bone marrow failure 28.82 10.60 95 190261 29690 29732432
Spinal operation 28.68 10.60 52 190304 2244 29759878
Opiates positive 28.66 10.60 19 190337 247 29761875
Stevens-Johnson syndrome 28.55 10.60 42 190314 17514 29744608
Pyrexia 28.50 10.60 1556 188800 292933 29469189
Pancreatitis acute 28.43 10.60 77 190279 25618 29736504
Drug detoxification 28.37 10.60 18 190338 216 29761906
Rhabdomyolysis 27.75 10.60 264 190092 63316 29698806
Cerebral infarction 27.73 10.60 81 190275 26292 29735830
Tumour pain 27.72 10.60 33 190323 967 29761155
Hyperkalaemia 27.59 10.60 277 190079 65733 29696389
Deep vein thrombosis 27.28 10.60 538 189818 59963 29702159
Jaundice 27.22 10.60 110 190246 32376 29729746
Deafness neurosensory 27.14 10.60 52 190304 2341 29759781
Colitis ulcerative 27.11 10.60 31 190325 14403 29747719
Tuberculosis 26.67 10.60 9 190347 8068 29754054
Glomerular filtration rate decreased 26.54 10.60 20 190336 11342 29750780
Injection site pain 26.44 10.60 101 190255 30209 29731913
Drug screen negative 26.39 10.60 18 190338 246 29761876
Intestinal sepsis 26.22 10.60 22 190334 417 29761705
Self-medication 26.20 10.60 50 190306 2244 29759878
Alanine aminotransferase abnormal 26.20 10.60 54 190302 2565 29759557
Product formulation issue 26.19 10.60 24 190332 514 29761608
Blood creatinine increased 26.02 10.60 416 189940 90959 29671163
Septic shock 25.73 10.60 269 190087 63338 29698784
Back injury 25.35 10.60 64 190292 3481 29758641
Diabetic ketoacidosis 25.27 10.60 39 190317 15947 29746175
Loss of personal independence in daily activities 25.25 10.60 228 190128 21307 29740815
Diabetes mellitus 25.24 10.60 159 190197 41706 29720416
Hypoaesthesia 25.05 10.60 484 189872 53746 29708376
Joint arthroplasty 24.90 10.60 25 190331 602 29761520
Anaemia 24.80 10.60 1075 189281 206917 29555205
Pulmonary embolism 24.71 10.60 661 189695 77474 29684648
Allodynia 24.70 10.60 25 190331 608 29761514
Multiple organ dysfunction syndrome 24.67 10.60 271 190085 63216 29698906
Premature baby 24.26 10.60 43 190313 16648 29745474
Anaphylactic shock 24.23 10.60 32 190324 13961 29748161
Gamma-glutamyltransferase increased 24.21 10.60 100 190256 29250 29732872
Peritonitis bacterial 24.14 10.60 22 190334 11356 29750766
Lower respiratory tract infection 23.96 10.60 88 190268 26626 29735496
Postmortem blood drug level abnormal 23.94 10.60 16 190340 211 29761911
Feeling abnormal 23.71 10.60 499 189857 56257 29705865
Peritonitis 23.69 10.60 64 190292 21311 29740811
Arthropathy 23.57 10.60 218 190138 20509 29741613
Myalgia 23.54 10.60 344 190012 76323 29685799
Respiratory tract infection 23.40 10.60 39 190317 15467 29746655
Therapeutic product effect incomplete 23.34 10.60 123 190233 33711 29728411
Lip swelling 23.26 10.60 28 190328 12716 29749406
Medication error 23.06 10.60 219 190137 20753 29741369
Aplasia pure red cell 23.00 10.60 4 190352 5622 29756500
Sinus tachycardia 22.93 10.60 173 190183 15331 29746791
Ventricular fibrillation 22.92 10.60 38 190318 15100 29747022
Venoocclusive liver disease 22.48 10.60 7 190349 6606 29755516
Extrapyramidal disorder 22.30 10.60 21 190335 10672 29751450
Blood creatine phosphokinase increased 22.28 10.60 175 190181 43673 29718449
Granulocytopenia 22.25 10.60 6 190350 6220 29755902
Post laminectomy syndrome 22.24 10.60 15 190341 201 29761921
Acute graft versus host disease 22.23 10.60 5 190351 5859 29756263
Exposure during pregnancy 22.02 10.60 16 190340 9245 29752877
Basal cell carcinoma 21.93 10.60 43 190313 16025 29746097
Eosinophil count increased 21.92 10.60 10 190346 7463 29754659
Hypersensitivity 21.64 10.60 229 190127 53799 29708323
Blood pressure decreased 21.61 10.60 193 190163 46882 29715240
Anaphylactic reaction 21.45 10.60 98 190258 27884 29734238
Coronary artery disease 21.44 10.60 207 190149 49505 29712617
Bronchopulmonary aspergillosis 21.36 10.60 28 190328 12256 29749866
Nasal necrosis 21.24 10.60 9 190347 42 29762080
Myelosuppression 21.16 10.60 10 190346 7312 29754810
Rib fracture 21.16 10.60 146 190210 12574 29749548
Pathological fracture 21.15 10.60 66 190290 4060 29758062
Tongue disorder 21.11 10.60 68 190288 4254 29757868
Tachyphylaxis 21.00 10.60 11 190345 89 29762033
Parkinsonism 20.90 10.60 10 190346 7259 29754863
Progressive multifocal leukoencephalopathy 20.88 10.60 16 190340 8997 29753125
Hypertriglyceridaemia 20.58 10.60 13 190343 8085 29754037
Back disorder 20.52 10.60 84 190272 5910 29756212
Haematuria 20.49 10.60 184 190172 44650 29717472
Blood triglycerides increased 20.47 10.60 36 190320 13981 29748141
Poisoning deliberate 20.42 10.60 83 190273 5821 29756301
Victim of homicide 20.27 10.60 12 190344 126 29761996
Neutrophil count increased 20.07 10.60 42 190314 15281 29746841
Sickle cell anaemia with crisis 20.01 10.60 46 190310 2356 29759766
Pruritus 19.99 10.60 585 189771 117619 29644503
Metastases to bone 19.86 10.60 117 190239 9541 29752581
Atrial septal defect 19.60 10.60 9 190347 6692 29755430
Pupillary reflex impaired 19.52 10.60 35 190321 1497 29760625
Shock 19.41 10.60 77 190279 22782 29739340
Cholestasis 19.36 10.60 87 190269 24863 29737259
Pemphigoid 19.25 10.60 12 190344 7516 29754606
Post transplant lymphoproliferative disorder 19.18 10.60 5 190351 5301 29756821
Product prescribing error 19.03 10.60 176 190180 16557 29745565
Tooth loss 18.99 10.60 62 190294 3907 29758215
Mucormycosis 18.97 10.60 5 190351 5263 29756859
Cerebral haematoma 18.92 10.60 3 190353 4511 29757611
Metastatic renal cell carcinoma 18.89 10.60 46 190310 2446 29759676
Hepatic enzyme increased 18.78 10.60 130 190226 33364 29728758
Nephropathy toxic 18.76 10.60 24 190332 10615 29751507
Pulmonary congestion 18.68 10.60 138 190218 12149 29749973
Renal cell carcinoma 18.34 10.60 79 190277 5687 29756435
Swollen tongue 18.27 10.60 35 190321 13157 29748965
Nervousness 18.27 10.60 133 190223 11655 29750467
Electrocardiogram QT prolonged 18.21 10.60 143 190213 35692 29726430
Cardiac failure acute 18.15 10.60 19 190337 9190 29752932
Acute generalised exanthematous pustulosis 18.13 10.60 8 190348 6090 29756032
Myelodysplastic syndrome 18.09 10.60 60 190296 18718 29743404
Spinal fusion surgery 18.07 10.60 24 190332 787 29761335
Hepatitis B 18.00 10.60 8 190348 6064 29756058
Arrhythmia 17.98 10.60 130 190226 33039 29729083
Acute coronary syndrome 17.95 10.60 37 190319 13536 29748586
Device issue 17.95 10.60 14 190342 7802 29754320
Mania 17.92 10.60 19 190337 9135 29752987
Graft versus host disease 17.79 10.60 23 190333 10127 29751995
Brain death 17.67 10.60 45 190311 2461 29759661
Hepatocellular carcinoma 17.66 10.60 21 190335 9589 29752533
Epistaxis 17.58 10.60 234 190122 52747 29709375
Ventricular tachycardia 17.45 10.60 85 190271 23777 29738345
Haemophagocytic lymphohistiocytosis 17.36 10.60 22 190334 9769 29752353
Atrioventricular block complete 17.27 10.60 17 190339 8460 29753662
Spinal disorder 17.21 10.60 54 190302 3331 29758791
Lumbar vertebral fracture 17.07 10.60 37 190319 1821 29760301
Gastric haemorrhage 17.07 10.60 21 190335 9446 29752676
Euphoric mood 17.03 10.60 63 190293 4227 29757895
Feeding disorder 16.83 10.60 78 190278 5793 29756329
Acute graft versus host disease in skin 16.82 10.60 4 190352 4512 29757610
Pulmonary tuberculosis 16.77 10.60 5 190351 4852 29757270
Formication 16.71 10.60 35 190321 1682 29760440
Tubulointerstitial nephritis 16.67 10.60 58 190298 17833 29744289
COVID-19 16.63 10.60 58 190298 17820 29744302
Artery dissection 16.58 10.60 10 190346 109 29762013
Infective pulmonary exacerbation of cystic fibrosis 16.55 10.60 18 190338 8554 29753568
Near death experience 16.48 10.60 8 190348 54 29762068
Insomnia 16.45 10.60 738 189618 92598 29669524
Concomitant disease aggravated 16.44 10.60 6 190350 5123 29756999
Signet-ring cell carcinoma 16.42 10.60 5 190351 6 29762116
Eczema 16.39 10.60 38 190318 13331 29748791
Troponin T increased 16.37 10.60 31 190325 1383 29760739
Injection site swelling 16.33 10.60 19 190337 8761 29753361
Hepatocellular injury 16.26 10.60 95 190261 25376 29736746
Catatonia 16.08 10.60 4 190352 4376 29757746
Environmental exposure 16.02 10.60 14 190342 281 29761841
Spinal cord ischaemia 15.92 10.60 9 190347 86 29762036
Non-small cell lung cancer 15.85 10.60 56 190300 3674 29758448
Thermophobia 15.75 10.60 9 190347 88 29762034
Hepatic pain 15.71 10.60 29 190327 1269 29760853
Snoring 15.52 10.60 47 190309 2844 29759278
Cardiac failure chronic 15.48 10.60 9 190347 5854 29756268
Adenovirus infection 15.47 10.60 4 190352 4264 29757858
Pulmonary arterial hypertension 15.37 10.60 22 190334 9279 29752843
Kidney transplant rejection 15.36 10.60 15 190341 7494 29754628
Metastases to spine 15.36 10.60 40 190316 2218 29759904
Blood glucose increased 15.29 10.60 287 190069 61243 29700879
Haemodynamic instability 15.29 10.60 17 190339 7998 29754124
Renal failure 15.24 10.60 667 189689 128299 29633823
Intervertebral disc disorder 15.10 10.60 34 190322 1717 29760405
Dental caries 15.10 10.60 62 190294 4369 29757753
Hepatitis 15.02 10.60 82 190274 22274 29739848
Facet joint syndrome 15.01 10.60 12 190344 212 29761910
Hypophagia 14.91 10.60 211 190145 22025 29740097
Alcohol use 14.79 10.60 55 190301 3700 29758422
Intraocular pressure increased 14.79 10.60 7 190349 5113 29757009
Small intestinal obstruction 14.70 10.60 142 190214 13517 29748605
Spinal cord compression 14.69 10.60 54 190302 3612 29758510
Therapeutic product effect decreased 14.63 10.60 263 190093 28813 29733309
Serotonin syndrome 14.61 10.60 176 190180 17715 29744407
Sciatic nerve neuropathy 14.56 10.60 8 190348 72 29762050
Aptyalism 14.41 10.60 12 190344 225 29761897
Therapeutic response decreased 14.40 10.60 93 190263 24256 29737866
Idiopathic pulmonary fibrosis 14.40 10.60 4 190352 4065 29758057
Hepatic function abnormal 14.38 10.60 184 190172 41761 29720361
Myocarditis 14.36 10.60 26 190330 9985 29752137
Substance use disorder 14.33 10.60 9 190347 106 29762016
Pneumocystis jirovecii pneumonia 14.32 10.60 58 190298 17062 29745060
Nasopharyngitis 14.16 10.60 276 190080 58573 29703549
Hypotension 14.16 10.60 1090 189266 199475 29562647
Metabolic encephalopathy 14.14 10.60 55 190301 3780 29758342
Victim of crime 14.13 10.60 13 190343 280 29761842
Metabolic acidosis 14.11 10.60 161 190195 37300 29724822
Intervertebral disc protrusion 14.02 10.60 104 190252 9167 29752955
Liver disorder 14.01 10.60 121 190235 29601 29732521
Tooth disorder 13.99 10.60 103 190253 9058 29753064
Chest discomfort 13.98 10.60 204 190152 45276 29716846
Myositis 13.97 10.60 28 190328 10349 29751773
Brain injury 13.96 10.60 71 190285 5477 29756645
Status epilepticus 13.96 10.60 31 190325 11041 29751081
Hypogammaglobulinaemia 13.95 10.60 8 190348 5244 29756878
Subarachnoid haemorrhage 13.89 10.60 26 190330 9860 29752262
Infusion related reaction 13.88 10.60 178 190178 40386 29721736
Androgen deficiency 13.87 10.60 11 190345 192 29761930
Carbon monoxide poisoning 13.84 10.60 9 190347 113 29762009
Bronchospasm 13.82 10.60 28 190328 10310 29751812
Spinal cord injury 13.81 10.60 14 190342 341 29761781
Stomatitis 13.74 10.60 322 190034 36957 29725165
Chronic kidney disease 13.72 10.60 164 190192 37674 29724448
Learning disability 13.71 10.60 10 190346 153 29761969
Maternal drugs affecting foetus 13.70 10.60 5 190351 4268 29757854
Lumbar radiculopathy 13.67 10.60 22 190334 861 29761261
Spinal laminectomy 13.65 10.60 12 190344 243 29761879
Eyelid ptosis 13.64 10.60 8 190348 5180 29756942
Ileus 13.58 10.60 155 190201 15400 29746722
Dehydration 13.53 10.60 935 189421 122604 29639518
Flushing 13.49 10.60 121 190235 29371 29732751
Vestibular ischaemia 13.49 10.60 5 190351 15 29762107
Lung cancer metastatic 13.48 10.60 41 190315 2487 29759635
Lymphadenopathy 13.47 10.60 95 190261 24281 29737841
Hypokalaemia 13.46 10.60 231 190125 49961 29712161
Salivary hypersecretion 13.41 10.60 17 190339 7549 29754573
Coronary arterial stent insertion 13.29 10.60 5 190351 4189 29757933
General physical health deterioration 13.28 10.60 510 189846 99434 29662688
Face oedema 13.28 10.60 33 190323 11301 29750821
Product prescribing issue 13.23 10.60 21 190335 812 29761310
Prescribed underdose 13.17 10.60 18 190338 7741 29754381
Disease recurrence 13.13 10.60 46 190310 14115 29748007
Inflammation 13.09 10.60 84 190272 21942 29740180
Dizziness 13.02 10.60 1064 189292 193845 29568277
Sarcopenia 12.91 10.60 12 190344 262 29761860
Surgery 12.88 10.60 121 190235 11430 29750692
Injection site reaction 12.86 10.60 31 190325 10729 29751393
Weight increased 12.84 10.60 370 189986 74543 29687579
Complications of transplanted kidney 12.81 10.60 5 190351 4096 29758026
Hypogonadism 12.74 10.60 28 190328 1391 29760731
Suicidal ideation 12.72 10.60 310 190046 35804 29726318
Treatment failure 12.69 10.60 150 190206 34529 29727593
Rash maculo-papular 12.65 10.60 102 190254 25316 29736806
Muscle spasms 12.61 10.60 518 189838 64320 29697802
Decreased gait velocity 12.61 10.60 8 190348 96 29762026
Subdural haematoma 12.52 10.60 70 190286 18902 29743220
Rash 12.44 10.60 1050 189306 190839 29571283
Renal injury 12.34 10.60 36 190320 11693 29750429
Delirium tremens 12.32 10.60 16 190340 513 29761609
Amphetamines positive 12.20 10.60 7 190349 69 29762053
Grief reaction 12.20 10.60 7 190349 69 29762053
Lumbosacral plexopathy 12.20 10.60 3 190353 0 29762122
Analgesic drug level decreased 12.20 10.60 3 190353 0 29762122
Coronary artery bypass 12.17 10.60 9 190347 5153 29756969
Prostate cancer metastatic 12.16 10.60 64 190292 5003 29757119
Upper gastrointestinal haemorrhage 12.10 10.60 86 190270 21942 29740180
Angina unstable 12.09 10.60 39 190317 12271 29749851
Influenza virus test positive 12.07 10.60 8 190348 104 29762018
Aspiration 12.01 10.60 111 190245 10440 29751682
Cardiovascular disorder 11.98 10.60 33 190323 10919 29751203
Drug level increased 11.96 10.60 68 190288 18286 29743836
Loss of consciousness 11.95 10.60 618 189738 78757 29683365
Agitation 11.93 10.60 438 189918 53635 29708487
Aggression 11.89 10.60 164 190192 36743 29725379
Visual acuity reduced 11.85 10.60 56 190300 15790 29746332
Foetal growth restriction 11.83 10.60 4 190352 3581 29758541
Myoclonus 11.78 10.60 133 190223 13179 29748943
Body height decreased 11.75 10.60 51 190305 3683 29758439
Failure to anastomose 11.72 10.60 11 190345 243 29761879
Limb crushing injury 11.72 10.60 6 190350 46 29762076
Red blood cell sedimentation rate increased 11.70 10.60 83 190273 7212 29754910
Aplastic anaemia 11.48 10.60 11 190345 5545 29756577
Lymphoma 11.44 10.60 30 190326 10091 29752031
Lymphopenia 11.39 10.60 44 190312 13119 29749003
Post-traumatic stress disorder 11.39 10.60 29 190327 1586 29760536
Blood urea increased 11.38 10.60 136 190220 31245 29730877
Hypertension 11.35 10.60 643 189713 120711 29641411
Upper limb fracture 11.27 10.60 54 190302 4066 29758056
Muscle rigidity 11.16 10.60 31 190325 10230 29751892
Pseudomonas infection 11.16 10.60 32 190324 10450 29751672
Hypoxic-ischaemic encephalopathy 11.11 10.60 59 190297 4628 29757494
Partial seizures 11.11 10.60 5 190351 3762 29758360
Scar pain 11.11 10.60 6 190350 52 29762070
Toothache 11.06 10.60 69 190287 5742 29756380
Decubitus ulcer 11.01 10.60 86 190270 7702 29754420
Visual impairment 11.01 10.60 132 190224 30306 29731816
Purpura 10.93 10.60 30 190326 9937 29752185
Xyphoid retraction 10.89 10.60 9 190347 167 29761955
Injection site erythema 10.87 10.60 48 190308 13786 29748336
Hypertensive crisis 10.87 10.60 23 190333 8334 29753788
Hypertensive heart disease 10.86 10.60 37 190319 2383 29759739
Acute on chronic liver failure 10.83 10.60 8 190348 125 29761997
Neonatal respiratory distress syndrome 10.82 10.60 6 190350 4006 29758116
Dyspnoea 10.80 10.60 1909 188447 331386 29430736
Pulmonary function test decreased 10.77 10.60 7 190349 4288 29757834
Disability 10.74 10.60 56 190300 4362 29757760
Urinary tract infection 10.65 10.60 372 189984 73287 29688835
Oesophageal infection 10.62 10.60 10 190346 222 29761900
Pupillary light reflex tests abnormal 10.61 10.60 8 190348 129 29761993

Pharmacologic Action:

SourceCodeDescription
ATC N02AA05 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA55 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA56 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AJ17 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ18 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ19 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35482 narcotic analgesics
CHEBI has role CHEBI:51177 cough suppressant
CHEBI has role CHEBI:55322 mu opioid agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Severe pain indication 76948002
Acute postoperative pain indication 107401000119105
Chronic Pain with Opioid Tolerance indication
Neuropathic pain off-label use 247398009
Hypophosphatemia contraindication 4996001
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Asthenia contraindication 13791008
Constipation contraindication 14760008 DOID:2089
Mood swings contraindication 18963009
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Gastrointestinal perforation contraindication 51875005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Hemorrhoids contraindication 70153002 DOID:9746
Poisoning by acetaminophen contraindication 70273001
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Cor pulmonale contraindication 83291003 DOID:8515
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Drug-induced psychosis contraindication 191483003 DOID:1742
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Morbid obesity contraindication 238136002 DOID:11981
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Skin irritation contraindication 367466007
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Cardiovascular event risk contraindication 395112001
Breastfeeding (mother) contraindication 413712001
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001
Acute erosive gastritis contraindication 444926003
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.97 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST Ki 7.80 WOMBAT-PK CHEMBL
Kappa-type opioid receptor GPCR EC50 4.80 CHEMBL
Delta-type opioid receptor GPCR EC50 5.40 CHEMBL
Acetylcholinesterase Enzyme IC50 4.12 CHEMBL
Kappa-type opioid receptor GPCR EC50 4.80 CHEMBL
Kappa-type opioid receptor GPCR Ki 5.58 CHEMBL
Delta-type opioid receptor GPCR Ki 5.96 CHEMBL
Mu-type opioid receptor GPCR Ki 7.36 CHEMBL
Mu-type opioid receptor GPCR EC50 6.80 CHEMBL

External reference:

IDSource
D00847 KEGG_DRUG
124-90-3 SECONDARY_CAS_RN
4017996 VANDF
4017997 VANDF
4019870 VANDF
C0030049 UMLSCUI
CHEBI:7852 CHEBI
CHEMBL656 ChEMBL_ID
CHEMBL1200890 ChEMBL_ID
CHEMBL3989826 ChEMBL_ID
DB00497 DRUGBANK_ID
D010098 MESH_DESCRIPTOR_UI
C016026 MESH_SUPPLEMENTAL_RECORD_UI
5284603 PUBCHEM_CID
7093 IUPHAR_LIGAND_ID
1701 INN_ID
CD35PMG570 UNII
159821 RXNORM
10664 MMSL
31648 MMSL
5216 MMSL
5217 MMSL
6369 MMSL
d00329 MMSL
001558 NDDF
001559 NDDF
004513 NDDF
116352007 SNOMEDCT_US
387024006 SNOMEDCT_US
414984009 SNOMEDCT_US
55452001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
oxycodone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0390 SOLUTION 5 mg ORAL ANDA 32 sections
Roxicet HUMAN PRESCRIPTION DRUG LABEL 2 0054-3686 SOLUTION 5 mg ORAL ANDA 23 sections
Roxicet HUMAN PRESCRIPTION DRUG LABEL 2 0054-4650 TABLET 5 mg ORAL ANDA 23 sections
Roxicet HUMAN PRESCRIPTION DRUG LABEL 2 0054-8648 SOLUTION 5 mg ORAL ANDA 23 sections
Roxicet HUMAN PRESCRIPTION DRUG LABEL 2 0054-8650 TABLET 5 mg ORAL ANDA 23 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-5731 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL NDA authorized generic 33 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-5732 TABLET, FILM COATED, EXTENDED RELEASE 20 mg ORAL NDA authorized generic 33 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-5733 TABLET, FILM COATED, EXTENDED RELEASE 40 mg ORAL NDA authorized generic 33 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-5734 TABLET, FILM COATED, EXTENDED RELEASE 80 mg ORAL NDA authorized generic 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1556 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1557 TABLET, FILM COATED, EXTENDED RELEASE 15 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1558 TABLET, FILM COATED, EXTENDED RELEASE 20 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1559 TABLET, FILM COATED, EXTENDED RELEASE 30 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1560 TABLET, FILM COATED, EXTENDED RELEASE 40 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1561 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1562 TABLET, FILM COATED, EXTENDED RELEASE 80 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0826 SOLUTION 100 mg ORAL ANDA 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0827 SOLUTION 5 mg ORAL ANDA 35 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-4827 SOLUTION 5 mg ORAL ANDA 35 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-4839 SOLUTION 5 mg ORAL ANDA 33 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2876 TABLET 5 mg ORAL ANDA 29 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2878 TABLET 15 mg ORAL ANDA 29 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2879 TABLET 30 mg ORAL ANDA 29 sections
OXYCODONE AND ACETAMINOPHEN HUMAN PRESCRIPTION DRUG LABEL 2 0406-0512 TABLET 5 mg ORAL ANDA 15 sections
OXYCODONE AND ACETAMINOPHEN HUMAN PRESCRIPTION DRUG LABEL 2 0406-0522 TABLET 7.50 mg ORAL ANDA 15 sections
OXYCODONE AND ACETAMINOPHEN HUMAN PRESCRIPTION DRUG LABEL 2 0406-0523 TABLET 10 mg ORAL ANDA 15 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-0552 TABLET 5 mg ORAL ANDA 29 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8515 TABLET 15 mg ORAL ANDA 29 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8530 TABLET 30 mg ORAL ANDA 29 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-8556 SOLUTION 5 mg ORAL ANDA 33 sections