oxycodone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2029 76-42-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxycontin
  • oxycodone
  • dihydro-14-hydroxycodeinone
  • dihydrohydroxycodeinone
  • dihydrone
  • oxicon
  • oxycodeinone
  • oxymorphone 3-methyl ether
  • oxynorm
  • oxycodone hydrochloride
  • oxycodone terephthalate
  • oxycodone hydrochloride hydrate
  • oxycodone HCl
A semisynthetic derivative of CODEINE.
  • Molecular weight: 315.37
  • Formula: C18H21NO4
  • CLOGP: -0.04
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 59
  • ALOGS: -1.75
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
30 mg P
75 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 166.67 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 19 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.06 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 73.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.55 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.50 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.802 Moderate 0.79
caco2-efflux Caco-2 efflux ratio (BA/AB) 4.603 Moderate 0.79
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 11.482 10^-6 cm/s Moderate 0.79
dh-clint Dog hepatocyte intrinsic clearance 7.925 uL/min/10^6 cells Moderate 0.79
dppb Dog plasma protein binding (% unbound) 77.410 % Moderate 0.79
fcs-ppb Fetal calf serum protein binding (% unbound) 82.180 % Moderate 0.79
herg hERG pIC50 4.657 pIC50 Moderate 0.79
hh-clint Human hepatocyte intrinsic clearance 1.549 uL/min/10^6 cells Moderate 0.79
hlm-clint Human liver microsomal intrinsic clearance 4.539 uL/min/mg protein Moderate 0.79
hppb Human plasma protein binding (% unbound) 77.290 % Moderate 0.79
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 36
kinase-selectivity-class EIF2AK3 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 6.622 Moderate 0.79
mh-clint Mouse hepatocyte intrinsic clearance 23.121 Moderate 0.79
mppb Mouse plasma protein binding (% unbound) 69.120 Moderate 0.79
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 27.416 Moderate 0.79
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 87.970 % Moderate 0.79
rh-clint Rat hepatocyte intrinsic clearance 18.365 uL/min/10^6 cells Moderate 0.79
rh-fuinc Rat hepatocyte fraction unbound in incubation 88.730 % Moderate 0.79
rppb Rat plasma protein binding (% unbound) 66.610 % Moderate 0.79
solubility-dd Solubility at pH 7.4 in DMSO 950.605 uM Moderate 0.79

Approvals:

DateAgencyCompanyOrphan
Oct. 29, 2020 PMDA SHIONOGI PHARMA CO., LTD
April 12, 1950 FDA ENDO PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Folliculitis 1318.63 9.98 3316 514193 201037 89909901
Completed suicide 1314.96 9.98 2694 514815 142364 89968574
Drug abuse 1295.99 9.98 1950 515559 80397 90030541
Irritable bowel syndrome 1206.71 9.98 3238 514271 204210 89906728
Muscle injury 1204.45 9.98 2928 514581 173726 89937212
Drug abuser 1180.84 9.98 478 517031 2212 90108726
Impaired healing 1010.92 9.98 3288 514221 230911 89880027
Lower respiratory tract infection 962.82 9.98 3384 514125 247275 89863663
Stomatitis 854.81 9.98 3467 514042 271231 89839707
Drug dependence 853.10 9.98 942 516567 28385 90082553
Sleep disorder due to general medical condition, insomnia type 834.31 9.98 2093 515416 126601 89984337
Blister 810.58 9.98 3240 514269 251758 89859180
Ill-defined disorder 753.93 9.98 2547 514962 182344 89928594
Confusional state 690.42 9.98 4162 513347 382043 89728895
Duodenal ulcer perforation 642.57 9.98 2735 514774 218553 89892385
Helicobacter infection 604.85 9.98 2733 514776 224117 89886821
Gastrointestinal disorder 548.61 9.98 2903 514606 253784 89857154
Cough 500.62 9.98 835 516674 368127 89742811
Peripheral swelling 499.68 9.98 4048 513461 409058 89701880
Off label use 461.17 9.98 4055 513454 1098197 89012741
Weight increased 452.33 9.98 3995 513514 413932 89697006
Drug withdrawal syndrome 451.33 9.98 680 516829 28043 90082895
Inadequate analgesia 441.61 9.98 258 517251 2966 90107972
Respiratory arrest 435.56 9.98 725 516784 32586 90078352
Drug ineffective 429.92 9.98 5461 512048 1378837 88732101
Toxicity to various agents 428.96 9.98 2964 514545 284882 89826056
Pericarditis 415.73 9.98 2804 514705 267347 89843591
Injury 383.15 9.98 2175 515334 195174 89915764
Sinusitis 367.54 9.98 3273 514236 339815 89771123
Night sweats 360.73 9.98 1575 515934 127191 89983747
Injection site pain 333.58 9.98 300 517209 173399 89937539
Infection 333.37 9.98 3345 514164 358749 89752189
Therapeutic product effect decreased 326.56 9.98 2704 514805 274867 89836071
Anti-cyclic citrullinated peptide antibody positive 324.41 9.98 2387 515122 234046 89876892
COVID-19 311.99 9.98 302 517207 168541 89942397
Nasopharyngitis 297.23 9.98 3592 513917 403512 89707426
Lip dry 292.05 9.98 1247 516262 99708 90011230
Wound 282.16 9.98 2806 514703 300174 89810764
Product dose omission issue 281.87 9.98 797 516712 290890 89820048
Facet joint syndrome 281.30 9.98 1211 516298 97178 90013760
Synovitis 277.28 9.98 2991 514518 326761 89784177
Joint swelling 274.88 9.98 4215 513294 499085 89611853
Joint range of motion decreased 273.12 9.98 1510 515999 134133 89976805
Rheumatoid arthritis 269.22 9.98 3210 514299 359404 89751534
Fibromyalgia 269.06 9.98 2058 515451 204211 89906727
Swelling 266.71 9.98 3605 513904 415453 89695485
Hand deformity 264.09 9.98 2720 514789 293642 89817296
Sleep disorder 261.20 9.98 1981 515528 196049 89914889
Overdose 253.86 9.98 1656 515853 156053 89954885
Contusion 251.75 9.98 2363 515146 248853 89862085
Cardio-respiratory arrest 251.02 9.98 863 516646 62277 90048661
Wound infection 244.75 9.98 1229 516280 105173 90005765
Injection site erythema 232.15 9.98 137 517372 98365 90012573
Glossodynia 221.66 9.98 2809 514700 318970 89791968
Pemphigus 220.76 9.98 2843 514666 324021 89786917
Bursitis 216.49 9.98 1390 516119 130264 89980674
Hepatic enzyme increased 210.31 9.98 3056 514453 357680 89753258
Gait inability 206.68 9.98 1489 516020 144967 89965971
Device expulsion 201.97 9.98 7 517502 40879 90070059
Myelosuppression 197.38 9.98 34 517475 53557 90057381
Blood pressure increased 196.29 9.98 531 516978 196686 89914252
Drug interaction 194.35 9.98 864 516645 275589 89835349
Type 2 diabetes mellitus 193.75 9.98 1892 515617 201352 89909586
Peripheral venous disease 191.33 9.98 967 516542 82954 90027984
Substance abuse 189.82 9.98 192 517317 5214 90105724
Rheumatic fever 188.14 9.98 1507 516002 151614 89959324
Road traffic accident 187.32 9.98 1153 516356 106473 90004465
Delirium 185.42 9.98 1124 516385 103235 90007703
Injection site swelling 179.15 9.98 59 517450 59780 90051158
Respiratory depression 176.16 9.98 318 517191 15257 90095681
Psoriatic arthropathy 174.41 9.98 2033 515476 226302 89884636
Dry mouth 173.75 9.98 1710 515799 182349 89928589
Hypotension 173.69 9.98 1116 516393 324281 89786657
Discomfort 173.04 9.98 2357 515152 271978 89838960
Neutropenia 169.70 9.98 684 516825 224220 89886718
Abortion spontaneous 169.56 9.98 49 517460 54007 90056931
Erythema 168.73 9.98 704 516805 228542 89882396
Systemic lupus erythematosus 166.95 9.98 2949 514560 358947 89751991
Influenza 163.16 9.98 344 517165 138920 89972018
Medication error 156.94 9.98 922 516587 83730 90027208
Myalgia 155.76 9.98 497 517012 174628 89936310
Cardiac failure 154.63 9.98 241 517268 109255 90001683
Breast cancer stage III 154.13 9.98 916 516593 83531 90027407
Chest discomfort 152.87 9.98 353 517156 138012 89972926
Urticaria 152.72 9.98 2572 514937 310162 89800776
Ear pain 145.94 9.98 685 516824 57017 90053921
Nasal congestion 145.17 9.98 157 517352 83257 90027681
Acute kidney injury 143.70 9.98 1155 516354 319232 89791706
Palpitations 143.00 9.98 359 517150 136369 89974569
Macular degeneration 142.25 9.98 23 517486 37947 90072991
Headache 142.20 9.98 3796 513713 858950 89251988
Accidental overdose 141.16 9.98 418 517091 27855 90083083
Insomnia 140.34 9.98 2679 514830 330795 89780143
Angioedema 138.27 9.98 101 517408 64775 90046163
Hypersensitivity 135.62 9.98 3477 514032 451200 89659738
Urinary tract infection 135.60 9.98 1105 516404 304527 89806411
Cataract 133.05 9.98 129 517380 71963 90038975
Prescribed overdose 131.64 9.98 982 516527 96643 90014295
Liver injury 130.79 9.98 1520 515989 169047 89941891
Infusion related reaction 129.24 9.98 3204 514305 413576 89697362
Atrial fibrillation 128.99 9.98 365 517144 133246 89977692
Rhinorrhoea 128.93 9.98 190 517319 88126 90022812
Lower limb fracture 127.88 9.98 878 516631 84135 90026803
Oropharyngeal pain 126.33 9.98 295 517214 114892 89996046
Syncope 125.44 9.98 366 517143 132297 89978641
Swollen joint count increased 123.49 9.98 1070 516439 110136 90000802
Arthropathy 123.09 9.98 2847 514662 363395 89747543
C-reactive protein abnormal 122.71 9.98 1189 516320 126240 89984698
Drug ineffective for unapproved indication 122.12 9.98 120 517389 66524 90044414
Blood cholesterol increased 119.38 9.98 1758 515751 206254 89904684
Foetal exposure during pregnancy 119.11 9.98 48 517461 42927 90068011
Pruritus 117.25 9.98 3979 513530 537546 89573392
Death 116.79 9.98 3423 514086 453128 89657810
Blepharospasm 116.76 9.98 625 516884 54820 90056118
Inappropriate schedule of product administration 116.23 9.98 451 517058 149482 89961456
Osteoarthritis 116.20 9.98 1664 515845 194066 89916872
Deep vein thrombosis postoperative 114.75 9.98 745 516764 70064 90040874
Anaemia 112.88 9.98 1380 516129 351422 89759516
Muscle spasticity 112.87 9.98 450 517059 34872 90076066
Back injury 112.48 9.98 546 516963 46076 90064862
Anaphylactic reaction 110.40 9.98 207 517302 87317 90023621
Autoimmune disorder 110.38 9.98 784 516725 75960 90034978
Drug reaction with eosinophilia and systemic symptoms 108.72 9.98 54 517455 42704 90068234
Lung disorder 108.43 9.98 1321 516188 148562 89962376
Body temperature increased 108.15 9.98 524 516985 44186 90066752
Nail disorder 107.96 9.98 641 516868 58426 90052512
Hyperaesthesia 106.68 9.98 207 517302 10495 90100443
Injection site pruritus 105.68 9.98 91 517418 53743 90057195
Grip strength decreased 105.54 9.98 896 516613 91680 90019258
Productive cough 104.67 9.98 174 517335 76889 90034049
Drug resistance 104.37 9.98 23 517486 30426 90080512
Seizure 104.19 9.98 482 517027 152147 89958791
Hypercholesterolaemia 101.40 9.98 950 516559 99942 90010996
Obesity 100.86 9.98 983 516526 104524 90006414
Inflammation 98.81 9.98 1500 516009 177092 89933846
Haematochezia 97.35 9.98 159 517350 70754 90040184
Taste disorder 96.96 9.98 643 516866 60903 90050035
Febrile neutropenia 96.67 9.98 520 516989 157829 89953109
Drug screen positive 96.21 9.98 113 517396 3644 90107294
Flushing 95.93 9.98 228 517281 88263 90022675
Injection site bruising 94.90 9.98 95 517414 52212 90058726
Abdominal pain upper 93.57 9.98 2525 514984 330149 89780789
C-reactive protein 92.63 9.98 390 517119 30977 90079961
Skin exfoliation 92.56 9.98 153 517356 67760 90043178
Red blood cell sedimentation rate abnormal 92.17 9.98 14 517495 24190 90086748
Vertigo 89.92 9.98 163 517346 69648 90041290
Product label confusion 89.64 9.98 311 517198 22539 90088399
Live birth 89.30 9.98 764 516745 78343 90032595
Miosis 87.98 9.98 178 517331 9306 90101632
Intentional product use issue 87.94 9.98 1733 515776 215159 89895779
Cardiac failure congestive 85.70 9.98 283 517226 98411 90012527
Premature delivery 85.69 9.98 58 517451 38704 90072234
Blood glucose increased 85.57 9.98 269 517240 94977 90015961
Cytomegalovirus infection 85.50 9.98 23 517486 26579 90084359
Musculoskeletal pain 84.80 9.98 1412 516097 169839 89941099
Onychomadesis 82.67 9.98 497 517012 45501 90065437
Hyponatraemia 82.35 9.98 437 517072 133101 89977837
Swelling face 81.67 9.98 218 517291 81134 90029804
Adjustment disorder with depressed mood 80.57 9.98 578 516931 56175 90054763
No adverse event 80.37 9.98 167 517342 67815 90043123
Cerebrovascular accident 80.29 9.98 397 517112 123136 89987802
Cardiac arrest 78.56 9.98 931 516578 104004 90006934
General physical health deterioration 78.17 9.98 2615 514894 352500 89758438
Renal impairment 77.96 9.98 323 517186 105098 90005840
Wheezing 77.51 9.98 1843 515666 236237 89874701
Contraindicated product administered 77.37 9.98 2384 515125 317755 89793183
Bradycardia 77.32 9.98 234 517275 83613 90027325
Wrong technique in product usage process 77.11 9.98 185 517324 71386 90039552
Stress 76.61 9.98 225 517284 81170 90029768
Diabetes mellitus 76.17 9.98 160 517349 64715 90046223
Accidental death 76.08 9.98 75 517434 1973 90108965
Sopor 76.08 9.98 23 517486 24621 90086317
Illness 75.41 9.98 229 517280 81740 90029198
Respiratory disorder 75.28 9.98 630 516879 64186 90046752
Cognitive disorder 73.52 9.98 181 517328 69226 90041712
Balance disorder 73.32 9.98 295 517214 96785 90014153
Mucosal inflammation 72.92 9.98 136 517373 57489 90053449
Dyspnoea exertional 72.35 9.98 194 517315 72094 90038844
Renal failure 72.02 9.98 445 517064 130562 89980376
Septic shock 71.92 9.98 243 517266 83917 90027021
Premature baby 71.16 9.98 27 517482 25050 90085888
Sinus disorder 70.37 9.98 56 517453 34391 90076547
Fall 70.20 9.98 2155 515354 479655 89631283
Angina pectoris 70.04 9.98 72 517437 39088 90071850
Maternal exposure timing unspecified 69.89 9.98 284 517225 22199 90088739
Malaise 69.86 9.98 2688 514821 583298 89527640
Epistaxis 69.24 9.98 251 517258 84874 90026064
Paraesthesia oral 69.15 9.98 48 517461 31611 90079327
Sneezing 68.33 9.98 43 517466 29826 90081112
Breast cancer stage II 68.17 9.98 389 517120 34945 90075993
Intentional product misuse 67.97 9.98 797 516712 88807 90022131
Throat irritation 67.95 9.98 108 517401 48587 90062351
Dislocation of vertebra 67.68 9.98 549 516960 55419 90055519
Respiratory tract infection 67.45 9.98 148 517361 58930 90052008
Sciatica 67.10 9.98 879 516630 100503 90010435
Orthostatic hypotension 67.09 9.98 84 517425 41743 90069195
Device difficult to use 67.05 9.98 10 517499 17515 90093423
Incorrect dose administered 66.70 9.98 229 517280 78701 90032237
Multiple organ dysfunction syndrome 66.44 9.98 186 517323 68150 90042788
Eye pruritus 66.11 9.98 42 517467 28985 90081953
Cystitis 66.05 9.98 180 517329 66538 90044400
Dizziness 65.95 9.98 2723 514786 586561 89524377
Sinus congestion 64.80 9.98 38 517471 27386 90083552
Device dislocation 64.53 9.98 51 517458 31431 90079507
Haemorrhage 64.38 9.98 193 517316 69176 90041762
Hypoaesthesia 64.16 9.98 2294 515215 311916 89799022
Pancytopenia 63.29 9.98 414 517095 119849 89991089
Lactic acidosis 62.19 9.98 121 517388 50342 90060596
Pleural fibrosis 62.06 9.98 89 517420 3507 90107431
Dry skin 61.36 9.98 276 517233 87797 90023141
Mouth ulceration 60.31 9.98 84 517425 39890 90071048
Proctitis 60.04 9.98 8 517501 15251 90095687
Eczema 59.90 9.98 133 517376 52737 90058201
Haemoglobin decreased 59.82 9.98 613 516896 161343 89949595
Exposure via ingestion 59.80 9.98 75 517434 2592 90108346
Dysphonia 59.64 9.98 174 517335 62910 90048028
Dysphagia 59.34 9.98 386 517123 111892 89999046
Bronchitis 59.33 9.98 572 516937 152355 89958583
Mobility decreased 58.13 9.98 1858 515651 248876 89862062
Anaphylactic shock 57.84 9.98 57 517452 31560 90079378
Creatinine renal clearance decreased 57.69 9.98 18 517491 18881 90092057
Diarrhoea 57.31 9.98 4602 512907 934588 89176350
Adverse reaction 57.25 9.98 327 517182 29385 90081553
Product quality issue 56.84 9.98 698 516811 78627 90032311
Swollen tongue 56.80 9.98 110 517399 45846 90065092
Therapeutic response shortened 56.52 9.98 30 517479 22849 90088089
Finger deformity 56.30 9.98 351 517158 32546 90078392
Chills 56.27 9.98 482 517027 131499 89979439
Therapeutic product effect incomplete 55.84 9.98 775 516734 193121 89917817
Gastrointestinal haemorrhage 55.82 9.98 295 517214 89953 90020985
Motor dysfunction 55.76 9.98 20 517489 19210 90091728
Presbyacusis 55.03 9.98 77 517432 2965 90107973
Plasma cell myeloma 54.63 9.98 410 517099 40418 90070520
Aplastic anaemia 54.56 9.98 6 517503 13263 90097675
Therapy partial responder 54.31 9.98 29 517480 22014 90088924
Heart rate increased 54.31 9.98 399 517110 112503 89998435
Hypoglycaemia 54.17 9.98 210 517299 69638 90041300
Viral infection 53.96 9.98 96 517413 41318 90069620
Injection site rash 53.66 9.98 36 517473 24137 90086801
Arrhythmia 53.48 9.98 100 517409 42232 90068706
Hepatotoxicity 53.03 9.98 114 517395 45728 90065210
Nausea 52.84 9.98 5544 511965 1104772 89006166
Pneumocystis jirovecii pneumonia 52.44 9.98 29 517480 21587 90089351
Memory impairment 52.27 9.98 1486 516023 195758 89915180
Back disorder 51.98 9.98 286 517223 25345 90085593
Sedation complication 51.97 9.98 16 517493 16928 90094010
Subcutaneous drug absorption impaired 51.96 9.98 183 517326 13362 90097576
Accidental exposure to product 51.85 9.98 102 517407 42264 90068674
Pyrexia 51.78 9.98 4411 513098 656074 89454864
Soft tissue disorder 51.62 9.98 90 517419 4200 90106738
Toxic epidermal necrolysis 51.47 9.98 66 517443 32462 90078476
Drug use disorder 51.19 9.98 133 517376 8210 90102728
Melaena 50.64 9.98 75 517434 34722 90076216
Interstitial lung disease 50.53 9.98 244 517265 76161 90034777
Incorrect route of product administration 50.50 9.98 476 517033 50150 90060788
Condition aggravated 50.40 9.98 2834 514675 592711 89518227
Injection site urticaria 50.10 9.98 20 517489 17991 90092947
Skin haemorrhage 49.99 9.98 30 517479 21350 90089588
Therapeutic response decreased 49.20 9.98 305 517204 89424 90021514
Secretion discharge 48.77 9.98 15 517494 15881 90095057
Acute lung injury 48.61 9.98 51 517458 1447 90109491
Haemophagocytic lymphohistiocytosis 48.50 9.98 14 517495 15445 90095493
Arthritis 48.44 9.98 668 516841 166647 89944291
Vision blurred 48.28 9.98 400 517109 109893 90001045
Suicide attempt 48.02 9.98 244 517265 75155 90035783
X-ray abnormal 47.79 9.98 432 517077 44992 90065946
Transaminases increased 47.75 9.98 87 517422 37105 90073833
Cardiotoxicity 47.21 9.98 5 517504 11384 90099554
Hemiparesis 46.88 9.98 68 517441 31751 90079187
Device issue 46.66 9.98 60 517449 29477 90081461
Agranulocytosis 46.63 9.98 80 517429 34922 90076016
Oxygen saturation decreased 46.51 9.98 391 517118 107092 90003846
Injection site haemorrhage 46.33 9.98 56 517453 28262 90082676
Myocardial infarction 46.08 9.98 385 517124 105587 90005351
Vaginal discharge 45.95 9.98 27 517482 19437 90091501
Epilepsy 45.64 9.98 691 516818 81515 90029423
Cardiogenic shock 44.89 9.98 44 517465 24424 90086514
Complication of device insertion 44.79 9.98 4 517505 10432 90100506
Lip swelling 44.67 9.98 96 517413 38514 90072424
Tremor 44.54 9.98 611 516898 152562 89958376
Infusion site pain 44.35 9.98 29 517480 19709 90091229
Pleural thickening 44.21 9.98 72 517437 3176 90107762
Cerebral haemorrhage 44.10 9.98 81 517428 34441 90076497
Haematotoxicity 43.92 9.98 9 517500 12526 90098412
Oral candidiasis 43.70 9.98 85 517424 35370 90075568
Blood pressure fluctuation 43.65 9.98 153 517356 52260 90058678
Femur fracture 43.64 9.98 127 517382 45955 90064983
Cardiac disorder 43.46 9.98 172 517337 56700 90054238
Multiple sclerosis relapse 43.35 9.98 153 517356 52152 90058786
Blood magnesium increased 42.98 9.98 73 517436 3335 90107603
Toxic leukoencephalopathy 42.90 9.98 37 517472 816 90110122
Myopathy 42.86 9.98 12 517497 13506 90097432
Poisoning 42.46 9.98 186 517323 15031 90095907
Bronchiectasis 42.32 9.98 39 517470 22291 90088647
Oesophageal motility disorder 42.11 9.98 33 517476 633 90110305
COVID-19 pneumonia 41.81 9.98 26 517483 18151 90092787
Delusional disorder, unspecified type 41.67 9.98 28 517481 418 90110520
Ischaemic stroke 41.67 9.98 39 517470 22127 90088811
Pulmonary arterial hypertension 41.57 9.98 53 517456 26134 90084804
Therapy interrupted 41.24 9.98 147 517362 49961 90060977
Procedural pain 41.10 9.98 80 517429 33280 90077658
Transplant rejection 41.06 9.98 11 517498 12747 90098191
Generalised tonic-clonic seizure 41.04 9.98 86 517423 34817 90076121
Dermatitis allergic 40.95 9.98 24 517485 17303 90093635
Respiratory rate decreased 40.88 9.98 78 517431 3905 90107033
Salpingo-oophorectomy unilateral 40.79 9.98 38 517471 930 90110008
Oral herpes 40.78 9.98 81 517428 33443 90077495
Withdrawal syndrome 40.23 9.98 243 517266 22281 90088657
Injection site mass 40.21 9.98 40 517469 22050 90088888
Ocular hyperaemia 39.97 9.98 83 517426 33715 90077223
General symptom 39.95 9.98 178 517331 14490 90096448
Glaucoma 39.63 9.98 36 517473 20719 90090219
Needle issue 39.54 9.98 15 517494 13919 90097019
Feeling abnormal 39.50 9.98 694 516815 166541 89944397
Dependence 39.35 9.98 54 517455 2041 90108897
Prescribed underdose 39.13 9.98 624 516885 74395 90036543
Full blood count abnormal 39.10 9.98 95 517414 36502 90074436
Depressed mood 38.94 9.98 151 517358 50071 90060867
Liver function test increased 38.49 9.98 690 516819 84165 90026773
Device breakage 38.41 9.98 16 517493 14028 90096910
Abdominal discomfort 38.33 9.98 3194 514315 474134 89636804
Unresponsive to stimuli 38.31 9.98 359 517150 37762 90073176
Liver disorder 38.29 9.98 935 516574 120334 89990604
Hepatic cytolysis 38.21 9.98 74 517435 30842 90080096
Status epilepticus 38.15 9.98 31 517478 18843 90092095
Vasculitis 38.06 9.98 44 517465 22649 90088289
Pleural effusion 37.69 9.98 433 517076 111558 89999380
Nasal necrosis 37.48 9.98 17 517492 109 90110829
Product dose omission in error 37.46 9.98 37 517472 20466 90090472
Rash erythematous 37.42 9.98 218 517291 64886 90046052
Electrocardiogram QT prolonged 37.32 9.98 251 517258 72205 90038733
Tachycardia 37.02 9.98 655 516854 157018 89953920
Bradypnoea 36.92 9.98 82 517427 4576 90106362
Diverticulitis 36.90 9.98 133 517376 45054 90065884
Mental status changes 36.85 9.98 404 517105 44275 90066663
Blood pressure decreased 36.83 9.98 263 517246 74632 90036306
Drug dose omission by device 36.57 9.98 7 517502 10224 90100714
Onychomycosis 36.57 9.98 350 517159 37026 90073912
Depression 36.54 9.98 2082 515427 298519 89812419
Suspected suicide 36.47 9.98 129 517380 9439 90101499
Coeliac disease 36.16 9.98 402 517107 44208 90066730
Presyncope 36.04 9.98 80 517429 31725 90079213
Haemoptysis 35.99 9.98 86 517423 33234 90077704
Circulatory collapse 35.93 9.98 54 517455 24850 90086088
Sputum discoloured 35.89 9.98 38 517471 20353 90090585
Inflammatory marker increased 35.85 9.98 5 517504 9209 90101729
Adverse event 35.79 9.98 901 516608 116517 89994421
Disease recurrence 35.49 9.98 104 517405 37549 90073389
Influenza like illness 35.43 9.98 292 517217 80319 90030619
Product complaint 35.40 9.98 162 517347 13338 90097600
White blood cell count decreased 35.28 9.98 707 516802 166402 89944536
Injection site warmth 35.12 9.98 29 517480 17486 90093452
Rash 35.02 9.98 5119 512390 790981 89319957
Narcotic bowel syndrome 34.98 9.98 17 517492 130 90110808
Blood test abnormal 34.74 9.98 41 517468 20911 90090027
Acne 34.57 9.98 69 517440 28438 90082500
Caesarean section 34.55 9.98 33 517476 18544 90092394
Limb discomfort 34.52 9.98 107 517402 37953 90072985
Gestational diabetes 34.29 9.98 9 517500 10573 90100365
Product storage error 34.22 9.98 39 517470 20202 90090736
Gamma-glutamyltransferase increased 34.21 9.98 107 517402 37845 90073093
Polyneuropathy 34.09 9.98 36 517473 19305 90091633
Pallor 33.95 9.98 92 517417 34073 90076865
Hypertensive crisis 33.77 9.98 31 517478 17753 90093185
Drug tolerance 33.75 9.98 196 517313 17720 90093218
Affect lability 33.70 9.98 32 517477 18031 90092907
Aspergillus infection 33.59 9.98 10 517499 10813 90100125
Rash papular 33.57 9.98 40 517469 20315 90090623
Uveitis 33.57 9.98 25 517484 15878 90095060
Hyperthyroidism 33.50 9.98 33 517476 18277 90092661
Myelodysplastic syndrome 33.50 9.98 42 517467 20861 90090077
Hyperkalaemia 33.48 9.98 225 517284 64739 90046199
Cytomegalovirus infection reactivation 33.45 9.98 3 517506 7797 90103141
Colitis microscopic 33.40 9.98 11 517498 11148 90099790
Rhinitis allergic 33.40 9.98 28 517481 16757 90094181
Sepsis 33.26 9.98 777 516732 179037 89931901
Exposure via skin contact 33.03 9.98 10 517499 10695 90100243
Gastrointestinal procedural complication 32.91 9.98 25 517484 457 90110481
Leukopenia 32.88 9.98 392 517117 100318 90010620
Dermatitis atopic 32.80 9.98 52 517457 23420 90087518
Feeling hot 32.75 9.98 286 517223 77722 90033216
Extrapyramidal disorder 32.68 9.98 27 517482 16276 90094662
Eye irritation 32.64 9.98 93 517416 33885 90077053
Hypothyroidism 32.11 9.98 175 517334 52952 90057986
Thrombocytopenia 31.96 9.98 927 516582 207798 89903140
Injection site induration 31.90 9.98 10 517499 10458 90100480
Exposure during pregnancy 31.86 9.98 1078 516431 237332 89873606
Abortion induced 31.78 9.98 14 517495 11874 90099064
Pulmonary fibrosis 31.61 9.98 821 516688 106682 90004256
Disability 31.59 9.98 364 517145 40381 90070557
Transient ischaemic attack 31.47 9.98 133 517376 43043 90067895
Rheumatoid factor positive 31.34 9.98 1238 516271 170412 89940526
Eosinophilia 31.33 9.98 73 517436 28460 90082478
Progressive multifocal leukoencephalopathy 31.29 9.98 26 517483 15629 90095309
Proteinuria 31.24 9.98 53 517456 23238 90087700
Personality disorder 31.21 9.98 16 517493 12428 90098510
Ulcer haemorrhage 31.18 9.98 257 517252 26064 90084874
Parkinsonism 31.15 9.98 21 517488 14044 90096894
Haematuria 31.14 9.98 99 517410 34838 90076100
Drug diversion 31.08 9.98 34 517475 1013 90109925
Herpes zoster 31.05 9.98 368 517141 94276 90016662
Hypokalaemia 30.99 9.98 544 516965 130572 89980366
Premature labour 30.95 9.98 19 517490 13357 90097581
Alanine aminotransferase increased 30.93 9.98 482 517027 117856 89993082
Pregnancy 30.83 9.98 512 516997 61535 90049403
Multiple-drug resistance 30.78 9.98 4 517505 7772 90103166
Low birth weight baby 30.78 9.98 8 517501 9459 90101479
Pneumonia 30.75 9.98 3182 514327 634877 89476061
Accidental exposure to product by child 30.71 9.98 38 517471 1295 90109643
Psychotic disorder 30.36 9.98 85 517424 31145 90079793
Demyelination 30.34 9.98 5 517504 8135 90102803
Oligohydramnios 30.27 9.98 3 517506 7198 90103740
Respiratory tract congestion 30.20 9.98 70 517439 27340 90083598
Eye disorder 30.13 9.98 70 517439 27320 90083618
Unintended pregnancy 30.06 9.98 4 517505 7633 90103305
Stevens-Johnson syndrome 30.03 9.98 78 517431 29298 90081640
Blood creatine phosphokinase increased 29.91 9.98 97 517412 33926 90077012
Rash maculo-papular 29.89 9.98 126 517383 40807 90070131
Rectal haemorrhage 29.80 9.98 315 517194 82429 90028509
Ventricular tachycardia 29.79 9.98 60 517449 24648 90086290
Subarachnoid haemorrhage 29.72 9.98 35 517474 17869 90093069
Intraocular pressure increased 29.70 9.98 3 517506 7090 90103848
Epstein-Barr virus infection 29.58 9.98 11 517498 10333 90100605
Aphthous ulcer 29.56 9.98 33 517476 17254 90093684
Torsade de pointes 29.39 9.98 26 517483 15156 90095782
Aphasia 29.31 9.98 135 517374 42677 90068261
Foetal megacystis 29.05 9.98 10 517499 26 90110912
Conjunctivitis 28.78 9.98 69 517440 26637 90084301
Oedema 28.70 9.98 1409 516100 198886 89912052
Hemiplegia 28.57 9.98 30 517479 16130 90094808
Chronic kidney disease 28.35 9.98 169 517340 50022 90060916
Abdominal pain 28.35 9.98 1912 515597 393809 89717129
Photosensitivity reaction 28.31 9.98 36 517473 17771 90093167
Intentional dose omission 28.22 9.98 36 517473 17747 90093191
Breast cancer female 28.21 9.98 26 517483 14860 90096078
Cholecystitis chronic 28.10 9.98 121 517388 9705 90101233
Adjustment disorder 28.00 9.98 10 517499 9632 90101306
Neuropathy peripheral 27.86 9.98 583 516926 136387 89974551
Breast cancer 27.80 9.98 186 517323 53575 90057363
Osteosclerosis 27.68 9.98 70 517439 4250 90106688
Acute myeloid leukaemia 27.66 9.98 47 517462 20593 90090345
Hypomagnesaemia 27.59 9.98 107 517402 35481 90075457
Hyperglycaemia 27.55 9.98 174 517335 50796 90060142
Product use issue 27.47 9.98 1572 515937 328347 89782591
Bone cyst 27.46 9.98 49 517460 2329 90108609
Tuberculosis 27.44 9.98 19 517490 12530 90098408
Drug level increased 27.40 9.98 75 517434 27687 90083251
Rash vesicular 27.39 9.98 188 517321 18009 90092929
Platelet count decreased 27.28 9.98 585 516924 136384 89974554
Maternal exposure before pregnancy 27.26 9.98 15 517494 11198 90099740
Lymphopenia 27.22 9.98 56 517453 22825 90088113
Therapy cessation 27.13 9.98 111 517398 36250 90074688
Nasal oedema 27.01 9.98 3 517506 6581 90104357
Cytopenia 26.99 9.98 36 517473 17413 90093525
Thrombotic microangiopathy 26.98 9.98 30 517479 15713 90095225
Pustular psoriasis 26.92 9.98 190 517319 18366 90092572
Immune reconstitution inflammatory syndrome 26.86 9.98 4 517505 7015 90103923
Foetal growth restriction 26.78 9.98 10 517499 9370 90101568
Cancer pain 26.61 9.98 66 517443 3959 90106979
Tinnitus 26.59 9.98 141 517368 42961 90067977
Hypogammaglobulinaemia 26.36 9.98 14 517495 10660 90100278
Skin plaque 26.27 9.98 12 517497 9963 90100975
Granulocytopenia 26.26 9.98 3 517506 6438 90104500
Glomerular filtration rate decreased 26.13 9.98 35 517474 16897 90094041
Device malfunction 26.11 9.98 50 517459 20927 90090011
Product use in unapproved indication 26.06 9.98 1613 515896 334623 89776315
Product preparation error 26.02 9.98 13 517496 10248 90100690
Weight decreased 25.99 9.98 1843 515666 378067 89732871
Gingival bleeding 25.98 9.98 28 517481 14875 90096063
Eosinophil count increased 25.81 9.98 22 517487 13059 90097879
Loss of personal independence in daily activities 25.76 9.98 586 516923 135519 89975419
Infusion site erythema 25.76 9.98 24 517485 13646 90097292
Hypervolaemia 25.71 9.98 98 517411 32659 90078279
Anosmia 25.70 9.98 12 517497 9836 90101102
Carpal tunnel syndrome 25.65 9.98 62 517447 23866 90087072
Coordination abnormal 25.63 9.98 52 517457 21304 90089634
Drug detoxification 25.59 9.98 19 517490 335 90110603
Immunosuppression 25.47 9.98 19 517490 12058 90098880
Eye pain 25.33 9.98 148 517361 44020 90066918
Infusion site swelling 25.29 9.98 18 517491 11702 90099236
Complication of device removal 25.29 9.98 3 517506 6252 90104686
Drug level decreased 25.17 9.98 12 517497 9718 90101220
Skin cancer 25.16 9.98 24 517485 13495 90097443
Lupus vulgaris 25.10 9.98 379 517130 44680 90066258
Pain of skin 25.06 9.98 33 517476 16049 90094889
Cardiovascular disorder 25.05 9.98 24 517485 13468 90097470
Malignant melanoma 24.99 9.98 21 517488 12555 90098383
Migraine 24.95 9.98 1328 516181 189064 89921874
Bacterial infection 24.93 9.98 61 517448 23383 90087555
Retinitis 24.84 9.98 332 517177 38126 90072812
Infusion site reaction 24.80 9.98 190 517319 18849 90092089
Stillbirth 24.76 9.98 6 517503 7437 90103501
Blood pressure diastolic decreased 24.63 9.98 75 517434 26751 90084187
Multiple drug therapy 24.62 9.98 5 517504 7004 90103934
Eye infection 24.60 9.98 27 517482 14227 90096711
Throat tightness 24.60 9.98 86 517423 29398 90081540
Arterial occlusive disease 24.47 9.98 21 517488 12425 90098513
Exostosis 24.43 9.98 433 517076 52701 90058237
Tonsillitis 24.42 9.98 5 517504 6964 90103974
Bronchospasm 24.37 9.98 51 517458 20658 90090280
Gastroenteritis viral 24.35 9.98 90 517419 30265 90080673
Thyroid disorder 24.29 9.98 40 517469 17745 90093193
Pathogen resistance 24.29 9.98 8 517501 8107 90102831
Seasonal allergy 24.28 9.98 60 517449 22923 90088015
Anti-cyclic citrullinated peptide antibody 24.25 9.98 250 517259 26971 90083967
Nodule 24.22 9.98 75 517434 26611 90084327
Glycosylated haemoglobin increased 24.18 9.98 32 517477 15530 90095408
Hypoacusis 24.07 9.98 80 517429 27770 90083168
Diabetic ketoacidosis 24.04 9.98 66 517443 24341 90086597
Acute myocardial infarction 23.90 9.98 110 517399 34780 90076158
Epigastric discomfort 23.84 9.98 96 517413 7472 90103466
Pain in jaw 23.83 9.98 168 517341 47817 90063121
Chronic sinusitis 23.72 9.98 64 517445 23738 90087200
Myositis 23.63 9.98 226 517283 23902 90087036
Injection site extravasation 23.52 9.98 11 517498 9008 90101930
Product formulation issue 23.51 9.98 24 517485 659 90110279
Drug intolerance 23.47 9.98 2909 514600 444682 89666256
Dermatitis bullous 23.39 9.98 15 517494 10301 90100637
Sphincter of Oddi dysfunction 23.38 9.98 20 517489 436 90110502
Sinusitis fungal 23.37 9.98 41 517468 1923 90109015
Purpura 23.36 9.98 30 517479 14748 90096190
Deafness neurosensory 23.35 9.98 89 517420 6752 90104186
Injection site discolouration 23.35 9.98 12 517497 9308 90101630
Choroidal infarction 23.33 9.98 12 517497 105 90110833
Pulmonary mass 23.29 9.98 85 517424 28687 90082251
Hepatic steatosis 23.27 9.98 120 517389 36825 90074113
Immunodeficiency 23.16 9.98 148 517361 43086 90067852
Pericardial effusion 22.99 9.98 120 517389 36713 90074225
Hypomania 22.98 9.98 11 517498 8886 90102052
Colitis 22.92 9.98 272 517237 69670 90041268
Schizophrenia 22.84 9.98 31 517478 14883 90096055
Spinal cord ischaemia 22.76 9.98 11 517498 83 90110855
Injection site reaction 22.74 9.98 379 517130 91701 90019237
Paradoxical drug reaction 22.74 9.98 3 517506 5763 90105175
Wheelchair user 22.74 9.98 8 517501 7777 90103161
Colitis ulcerative 22.70 9.98 227 517282 60039 90050899
Breath sounds abnormal 22.55 9.98 33 517476 15353 90095585
Skin burning sensation 22.49 9.98 49 517460 19562 90091376
Psoriasis 22.41 9.98 657 516852 147097 89963841
Eye swelling 22.37 9.98 89 517420 29297 90081641
Body temperature decreased 22.28 9.98 66 517443 23750 90087188
Subdural haematoma 22.21 9.98 38 517471 16607 90094331
Heavy menstrual bleeding 22.16 9.98 53 517456 20477 90090461
Pemphigoid 22.05 9.98 12 517497 9014 90101924
Optic neuritis 22.04 9.98 14 517495 9664 90101274
Diabetes mellitus inadequate control 21.99 9.98 46 517463 18638 90092300
Complication associated with device 21.97 9.98 49 517460 19400 90091538
Victim of homicide 21.93 9.98 10 517499 65 90110873
Bone density decreased 21.89 9.98 41 517468 17304 90093634
Blindness 21.82 9.98 78 517431 26490 90084448
Pneumonitis 21.76 9.98 155 517354 44015 90066923
Heart rate decreased 21.65 9.98 198 517311 53307 90057631
Amenorrhoea 21.59 9.98 21 517488 11701 90099237
Skin disorder 21.58 9.98 122 517387 36584 90074354
Skin reaction 21.57 9.98 46 517463 18507 90092431
Sinus bradycardia 21.45 9.98 40 517469 16912 90094026
Respiratory syncytial virus infection 21.45 9.98 17 517492 10463 90100475
Drug specific antibody present 21.43 9.98 3 517506 5511 90105427
Lymphocyte count decreased 21.43 9.98 115 517394 34935 90076003
Gastroenteritis 21.33 9.98 90 517419 29139 90081799
Hypocalcaemia 21.21 9.98 148 517361 42220 90068718
Amnesia 21.09 9.98 788 516721 107717 90003221
Dysgeusia 21.05 9.98 195 517314 52365 90058573
Intentional self-injury 20.99 9.98 91 517418 29243 90081695
Blood pressure abnormal 20.98 9.98 51 517458 19594 90091344
Left ventricular dysfunction 20.97 9.98 32 517477 14637 90096301
Pancreatitis acute 20.97 9.98 103 517406 32012 90078926
Product administration error 20.77 9.98 79 517430 26344 90084594
Upper-airway cough syndrome 20.71 9.98 34 517475 15101 90095837
Walking aid user 20.70 9.98 301 517208 35205 90075733
Genital haemorrhage 20.64 9.98 12 517497 8690 90102248
Papule 20.50 9.98 10 517499 7992 90102946
Blood iron decreased 20.49 9.98 45 517464 17914 90093024
Cellulitis 20.31 9.98 383 517126 90954 90019984
Partial seizures 20.30 9.98 8 517501 7252 90103686
Treatment noncompliance 20.25 9.98 193 517316 51534 90059404
Blood pressure systolic increased 20.25 9.98 224 517285 58121 90052817
Nephropathy 20.17 9.98 14 517495 9221 90101717
Mean cell haemoglobin decreased 20.14 9.98 4 517505 5691 90105247
Lung opacity 20.14 9.98 5 517504 6097 90104841
Velopharyngeal incompetence 20.12 9.98 7 517502 19 90110919
Atrioventricular block complete 19.97 9.98 16 517493 9795 90101143
Lacrimation increased 19.95 9.98 83 517426 26979 90083959
Blood creatinine increased 19.90 9.98 434 517075 100952 90009986
Gastrointestinal infection 19.89 9.98 20 517489 10970 90099968
Dry eye 19.87 9.98 223 517286 57708 90053230
Ear pruritus 19.85 9.98 7 517502 6796 90104142
Poor venous access 19.84 9.98 52 517457 19475 90091463
Sarcoidosis 19.80 9.98 19 517490 10654 90100284
Haematoma 19.74 9.98 136 517373 38912 90072026
Eyelid oedema 19.74 9.98 22 517487 11512 90099426
Visual acuity reduced 19.72 9.98 68 517441 23342 90087596
Jaundice 19.71 9.98 107 517402 32410 90078528
Acute on chronic liver failure 19.69 9.98 16 517493 324 90110614
Febrile bone marrow aplasia 19.68 9.98 16 517493 9722 90101216
Tardive dyskinesia 19.65 9.98 20 517489 10910 90100028
Rales 19.46 9.98 38 517471 15789 90095149
Blood lactate dehydrogenase increased 19.45 9.98 79 517430 25853 90085085
Diplopia 19.39 9.98 91 517418 28623 90082315
Drug hypersensitivity 19.36 9.98 2973 514536 460636 89650302
Disease progression 19.35 9.98 715 516794 155900 89955038
Ovarian cyst 19.26 9.98 44 517465 17274 90093664
Metastases to lymph nodes 19.24 9.98 23 517486 11666 90099272
Rash pustular 19.23 9.98 11 517498 8038 90102900
Enthesopathy 19.11 9.98 105 517404 9299 90101639
Coronary artery disease 19.10 9.98 113 517396 33510 90077428
Dyskinesia 19.09 9.98 126 517383 36408 90074530
Inappropriate antidiuretic hormone secretion 19.02 9.98 53 517456 19452 90091486
Loss of consciousness 18.98 9.98 633 516876 139605 89971333
Impaired quality of life 18.98 9.98 68 517441 23076 90087862
Hot flush 18.86 9.98 233 517276 59255 90051683
Ventricular extrasystoles 18.85 9.98 29 517480 13221 90097717
Cervix neoplasm 18.85 9.98 13 517496 203 90110735
Clear cell renal cell carcinoma 18.82 9.98 33 517476 1547 90109391
Dyslipidaemia 18.74 9.98 18 517491 10089 90100849
Drug level below therapeutic 18.74 9.98 5 517504 5809 90105129
Toxicologic test abnormal 18.72 9.98 22 517487 710 90110228
Organising pneumonia 18.71 9.98 10 517499 7587 90103351
Drug effective for unapproved indication 18.67 9.98 11 517498 7907 90103031
Insurance issue 18.65 9.98 21 517488 10937 90100001
Hepatic enzyme 18.64 9.98 70 517439 5274 90105664
Device use error 18.54 9.98 9 517500 7212 90103726
Jaundice cholestatic 18.49 9.98 18 517491 10025 90100913
Anoxia 18.47 9.98 14 517495 255 90110683
Sensory loss 18.47 9.98 48 517461 18027 90092911
Neutrophil count decreased 18.47 9.98 292 517217 71240 90039698
Compartment syndrome 18.46 9.98 47 517462 2865 90108073
Bone marrow failure 18.46 9.98 108 517401 32113 90078825
Infusion site extravasation 18.46 9.98 19 517490 10309 90100629
Eating disorder 18.36 9.98 90 517419 27983 90082955
Dementia 18.33 9.98 72 517437 23789 90087149
Spleen congestion 18.30 9.98 10 517499 100 90110838
Chronic obstructive pulmonary disease 18.19 9.98 304 517205 73525 90037413
Depressive symptom 18.10 9.98 4 517505 5281 90105657
Respiratory failure 18.10 9.98 526 516983 117892 89993046
Cardiac failure acute 18.06 9.98 25 517484 11904 90099034
Hepatic function abnormal 18.00 9.98 173 517336 46115 90064823
Platelet count increased 17.97 9.98 60 517449 20799 90090139
Poisoning deliberate 17.96 9.98 158 517351 16328 90094610
Pre-eclampsia 17.91 9.98 22 517487 11026 90099912
Congenital central hypoventilation syndrome 17.90 9.98 7 517502 29 90110909
Hypoaesthesia oral 17.87 9.98 39 517470 15561 90095377
Shock 17.83 9.98 94 517415 28684 90082254
Drug tolerance increased 17.81 9.98 13 517496 223 90110715
Blood glucose decreased 17.81 9.98 71 517438 23358 90087580
Atrial tachycardia 17.76 9.98 6 517503 5984 90104954
Blood uric acid increased 17.75 9.98 11 517498 7693 90103245
Diffuse large B-cell lymphoma 17.72 9.98 14 517495 8631 90102307
Aplasia pure red cell 17.65 9.98 4 517505 5190 90105748
Intermenstrual bleeding 17.61 9.98 16 517493 9207 90101731
Sensitivity to weather change 17.58 9.98 15 517494 8899 90102039
Diarrhoea haemorrhagic 17.54 9.98 21 517488 10642 90100296
Drug screen negative 17.53 9.98 15 517494 327 90110611
Secondary amyloidosis 17.53 9.98 12 517497 185 90110753
Obstructive airways disorder 17.46 9.98 82 517427 25787 90085151
Transfusion 17.44 9.98 47 517462 17441 90093497
Dermatitis exfoliative 17.39 9.98 5 517504 5531 90105407
Pulmonary hypertension 17.36 9.98 157 517352 42366 90068572
Asthma 17.33 9.98 1170 516339 240990 89869948
Mitral valve incompetence 17.28 9.98 68 517441 22456 90088482
SARS-CoV-2 test positive 17.17 9.98 23 517486 11105 90099833
Exercise tolerance decreased 17.09 9.98 11 517498 7540 90103398
Red blood cell sedimentation rate 17.07 9.98 62 517447 4596 90106342
Oesophageal achalasia 16.95 9.98 20 517489 648 90110290
Tongue disorder 16.82 9.98 113 517396 10747 90100191
Ventricular septal defect 16.77 9.98 5 517504 5402 90105536
Somnolence 16.73 9.98 1399 516110 207685 89903253
Burning sensation 16.72 9.98 258 517251 63194 90047744
Paranoid personality disorder 16.69 9.98 4 517505 0 90110938
Device occlusion 16.67 9.98 17 517492 9265 90101673
Gangrene 16.63 9.98 30 517479 12846 90098092
Patent ductus arteriosus 16.60 9.98 3 517506 4566 90106372
Rash macular 16.56 9.98 103 517406 30177 90080761
Aphonia 16.55 9.98 28 517481 12291 90098647
Haemorrhage intracranial 16.48 9.98 39 517470 15123 90095815
Serotonin syndrome 16.45 9.98 306 517203 37581 90073357
Haematocrit decreased 16.41 9.98 156 517353 41676 90069262
Cerebral infarction 16.41 9.98 87 517422 26509 90084429
Heart rate irregular 16.33 9.98 77 517432 24191 90086747
Shock haemorrhagic 16.30 9.98 28 517481 12217 90098721
BK virus infection 16.24 9.98 3 517506 4495 90106443
Nephrotic syndrome 16.20 9.98 11 517498 7328 90103610
Lymphadenopathy 16.18 9.98 175 517334 45600 90065338
Device leakage 16.09 9.98 20 517489 9971 90100967
Sleep terror 16.07 9.98 3 517506 4461 90106477
Dyspepsia 16.02 9.98 1327 516182 196833 89914105
Bradyphrenia 16.02 9.98 12 517497 7600 90103338
Sputum increased 16.00 9.98 45 517464 2912 90108026
Rebound effect 15.95 9.98 18 517491 9366 90101572
Pyelonephritis 15.95 9.98 65 517444 21251 90089687
Tooth loss 15.79 9.98 85 517424 7469 90103469
Faecalith 15.76 9.98 5 517504 9 90110929
Muscle spasms 15.75 9.98 1656 515853 250227 89860711
Eye inflammation 15.74 9.98 13 517496 7838 90103100
Embolism venous 15.73 9.98 51 517458 3569 90107369
Nystagmus 15.73 9.98 11 517498 7216 90103722
Polyarthritis 15.66 9.98 53 517456 18297 90092641
Multiple allergies 15.65 9.98 40 517469 15106 90095832
Acute pulmonary oedema 15.61 9.98 19 517490 9561 90101377
Multiple sclerosis 15.59 9.98 94 517415 27746 90083192
Cutaneous vasculitis 15.58 9.98 11 517498 7182 90103756
Tubulointerstitial nephritis 15.58 9.98 83 517426 25260 90085678
Increased appetite 15.57 9.98 27 517482 11738 90099200
Multiple fractures 15.55 9.98 19 517490 9543 90101395
Coronavirus infection 15.55 9.98 6 517503 5509 90105429
Dystonia 15.46 9.98 47 517462 16772 90094166
Tendon rupture 15.42 9.98 18 517491 9225 90101713
Periorbital oedema 15.26 9.98 10 517499 6789 90104149
Dermatitis 15.25 9.98 70 517439 22150 90088788
Bladder cancer 15.25 9.98 7 517502 5794 90105144
Polyuria 15.24 9.98 21 517488 10019 90100919
Feeling cold 15.24 9.98 93 517416 27372 90083566
Bronchopulmonary aspergillosis 15.23 9.98 26 517483 11372 90099566
Hepatocellular injury 15.07 9.98 100 517409 28858 90082080
Bladder disorder 14.92 9.98 24 517485 10748 90100190
Hepatic failure 14.81 9.98 150 517359 39578 90071360
Product residue present 14.79 9.98 56 517453 4235 90106703
Pseudomonas infection 14.79 9.98 40 517469 14825 90096113
Drug eruption 14.78 9.98 130 517379 35277 90075661
Radiculopathy 14.76 9.98 55 517454 18450 90092488
Concomitant disease aggravated 14.73 9.98 27 517482 11491 90099447
Faeces discoloured 14.73 9.98 67 517442 21253 90089685
Antidepressant drug level above therapeutic 14.70 9.98 16 517493 474 90110464
Petit mal epilepsy 14.64 9.98 5 517504 4953 90105985
Neutrophil count increased 14.59 9.98 59 517450 19331 90091607
Pharyngitis 14.56 9.98 70 517439 21877 90089061
Cardiac failure chronic 14.55 9.98 7 517502 5639 90105299
Pruritus genital 14.54 9.98 4 517505 4554 90106384
Performance enhancing product use 14.53 9.98 5 517504 13 90110925
Red blood cell count decreased 14.52 9.98 182 517327 46169 90064769
Sickle cell anaemia with crisis 14.51 9.98 81 517428 7216 90103722
Hypocholesterolaemia 14.47 9.98 74 517435 6375 90104563
Oesophageal obstruction 14.47 9.98 19 517490 688 90110250
Splenic injury 14.39 9.98 11 517498 203 90110735
Vaginal haemorrhage 14.33 9.98 112 517397 31159 90079779
Choroidal effusion 14.32 9.98 20 517489 769 90110169
Upper gastrointestinal haemorrhage 14.26 9.98 75 517434 22901 90088037
Nervous system disorder 14.25 9.98 69 517440 21524 90089414
Premature rupture of membranes 14.16 9.98 7 517502 5551 90105387
Diastolic hypotension 14.15 9.98 8 517501 86 90110852
Neck pain 14.15 9.98 791 516718 113172 89997766
Vitamin D deficiency 14.12 9.98 52 517457 17504 90093434
Tachypnoea 14.11 9.98 68 517441 21241 90089697
Urine abnormality 14.09 9.98 14 517495 7723 90103215
Renal disorder 14.09 9.98 143 517366 37716 90073222
Endoscopic retrograde cholangiopancreatography 14.08 9.98 11 517498 210 90110728
Myasthenia gravis 14.06 9.98 11 517498 6814 90104124
Poor quality sleep 14.02 9.98 83 517426 24610 90086328
Skin irritation 13.99 9.98 36 517473 13567 90097371
End stage renal disease 13.97 9.98 17 517492 8554 90102384
Foreign body embolism 13.94 9.98 4 517505 4 90110934
Blood urea increased 13.90 9.98 109 517400 30304 90080634
Blood immunoglobulin E increased 13.90 9.98 4 517505 4421 90106517
Sleep disorder due to a general medical condition 13.89 9.98 176 517333 44562 90066376
Skin toxicity 13.87 9.98 11 517498 6768 90104170
Facial paralysis 13.86 9.98 44 517465 15490 90095448
Learning disability 13.75 9.98 12 517497 269 90110669
Neutropenic sepsis 13.74 9.98 55 517454 18075 90092863
White blood cell count increased 13.73 9.98 286 517223 66955 90043983
Erythema multiforme 13.71 9.98 31 517478 12215 90098723
Mood altered 13.64 9.98 51 517458 17093 90093845
Decreased activity 13.61 9.98 16 517493 8176 90102762
Hyperprolactinaemia 13.60 9.98 7 517502 5426 90105512
Haemodialysis 13.58 9.98 18 517491 8729 90102209
Speech disorder 13.54 9.98 181 517328 45404 90065534
Acute generalised exanthematous pustulosis 13.54 9.98 37 517472 13666 90097272
Squamous cell carcinoma 13.53 9.98 23 517486 10078 90100860
Neurosis 13.52 9.98 14 517495 391 90110547
Skin discolouration 13.52 9.98 175 517334 44140 90066798
Brain injury 13.51 9.98 83 517426 7655 90103283
Sinus node dysfunction 13.51 9.98 7 517502 5405 90105533
Eyelid ptosis 13.51 9.98 19 517490 8987 90101951
Hypersensitivity pneumonitis 13.49 9.98 3 517506 3945 90106993
Pregnancy with contraceptive device 13.49 9.98 6 517503 5060 90105878
Escherichia bacteraemia 13.47 9.98 8 517501 5727 90105211
Catatonia 13.47 9.98 9 517500 6047 90104891
Postoperative wound infection 13.45 9.98 36 517473 13390 90097548
Erythema nodosum 13.43 9.98 8 517501 5716 90105222
Spinal operation 13.42 9.98 102 517407 10094 90100844
Rash pruritic 13.37 9.98 362 517147 81852 90029086
Ear infection 13.32 9.98 300 517209 69475 90041463
Impaired reasoning 13.30 9.98 9 517500 136 90110802
Neuroleptic malignant syndrome 13.30 9.98 43 517466 15053 90095885
Faeces soft 13.22 9.98 14 517495 7497 90103441
Decreased appetite 13.18 9.98 2392 515117 374148 89736790
Immune thrombocytopenia 13.15 9.98 36 517473 13290 90097648
Vitamin B12 deficiency 13.12 9.98 14 517495 7472 90103466
Blood calcium increased 13.12 9.98 31 517478 12027 90098911
Lymphoproliferative disorder 13.12 9.98 4 517505 4258 90106680
Renal function test abnormal 13.11 9.98 13 517496 7178 90103760
Vitamin B12 decreased 13.06 9.98 7 517502 5303 90105635
Embedded device 13.05 9.98 4 517505 4244 90106694
Upper respiratory tract infection 13.04 9.98 599 516910 127719 89983219
Temperature intolerance 13.03 9.98 31 517478 11999 90098939
Graft versus host disease in skin 13.02 9.98 3 517506 3850 90107088
Skin papilloma 13.02 9.98 8 517501 5622 90105316
Maternal exposure during delivery 12.99 9.98 3 517506 3843 90107095
Pulmonary granuloma 12.99 9.98 29 517480 1624 90109314
Pollakiuria 12.98 9.98 123 517386 32882 90078056
Blood calcium decreased 12.96 9.98 110 517399 30072 90080866
Large intestine polyp 12.92 9.98 21 517488 9365 90101573
Coronary artery occlusion 12.88 9.98 18 517491 8536 90102402
Coagulopathy 12.85 9.98 79 517430 23210 90087728
Paranasal sinus discomfort 12.80 9.98 10 517499 6200 90104738
Hyperkaliuria 12.73 9.98 7 517502 71 90110867
Gastric ulcer 12.72 9.98 98 517411 27350 90083588
Erysipelas 12.70 9.98 20 517489 9032 90101906
Deafness 12.61 9.98 76 517433 22438 90088500
Hysterectomy 12.61 9.98 111 517398 11473 90099465
Hepatitis B 12.60 9.98 5 517504 4514 90106424
Limb deformity 12.59 9.98 4 517505 4148 90106790
Pregnancy with implant contraceptive 12.57 9.98 3 517506 3758 90107180
Mean cell volume decreased 12.54 9.98 5 517504 4501 90106437
Chronic graft versus host disease 12.53 9.98 4 517505 4135 90106803
Cardiomyopathy 12.52 9.98 66 517443 20140 90090798
Hyperlipidaemia 12.50 9.98 78 517431 22838 90088100
Dermatitis contact 12.49 9.98 38 517471 13557 90097381
Therapy non-responder 12.45 9.98 924 516585 135780 89975158
Tooth infection 12.43 9.98 66 517443 20104 90090834
Escherichia urinary tract infection 12.42 9.98 39 517470 13776 90097162
Hepatitis toxic 12.40 9.98 3 517506 3722 90107216
Chemical burn 12.38 9.98 15 517494 500 90110438
Maternal drugs affecting foetus 12.38 9.98 7 517502 5148 90105790
Infective pulmonary exacerbation of cystic fibrosis 12.36 9.98 25 517484 10254 90100684
Acute graft versus host disease 12.33 9.98 8 517501 5460 90105478
Joint destruction 12.30 9.98 37 517472 13250 90097688
Neutrophilia 12.30 9.98 9 517500 5769 90105169
Periorbital swelling 12.29 9.98 6 517503 4792 90106146
Musculoskeletal discomfort 12.22 9.98 70 517439 20921 90090017
Acute hepatic failure 12.20 9.98 77 517432 22484 90088454
Viral upper respiratory tract infection 12.19 9.98 19 517490 8615 90102323
Haemodynamic instability 12.13 9.98 31 517478 11708 90099230
Intentional overdose 12.12 9.98 426 517083 93408 90017530
Stool analysis abnormal 12.12 9.98 6 517503 48 90110890
Head discomfort 12.10 9.98 50 517459 16283 90094655
Iridocyclitis 12.08 9.98 3 517506 3658 90107280
Injection site haematoma 12.07 9.98 13 517496 6909 90104029
Red cell distribution width increased 12.03 9.98 33 517476 12174 90098764
Renal pain 12.01 9.98 16 517493 7743 90103195
Haemolytic anaemia 12.00 9.98 31 517478 11666 90099272
Blood iron abnormal 11.97 9.98 4 517505 4016 90106922
Oropharyngeal discomfort 11.92 9.98 16 517493 7719 90103219
Haematemesis 11.90 9.98 129 517380 33597 90077341
Atrioventricular block 11.88 9.98 20 517489 8795 90102143
Anuria 11.84 9.98 44 517465 14774 90096164
Heart rate abnormal 11.83 9.98 10 517499 5961 90104977
Mouth swelling 11.82 9.98 9 517500 5653 90105285
Faecal calprotectin increased 11.81 9.98 4 517505 3983 90106955
Hunger 11.81 9.98 12 517497 6551 90104387
Non-small cell lung cancer 11.81 9.98 53 517456 4328 90106610
Autoimmune haemolytic anaemia 11.75 9.98 9 517500 5636 90105302
Atrial septal defect 11.74 9.98 18 517491 8216 90102722
Allodynia 11.70 9.98 21 517488 1003 90109935
Smear cervix abnormal 11.67 9.98 42 517467 3100 90107838
Enteritis 11.66 9.98 26 517483 10295 90100643
Gout 11.64 9.98 53 517456 16806 90094132
Polymyalgia rheumatica 11.61 9.98 7 517502 4970 90105968
Sleep disorder due to general medical condition, hypersomnia type 11.60 9.98 32 517477 2047 90108891
Ejection fraction decreased 11.58 9.98 95 517414 26158 90084780
Euglycaemic diabetic ketoacidosis 11.55 9.98 11 517498 6190 90104748
Aggression 11.54 9.98 97 517412 26571 90084367
Systemic candida 11.54 9.98 7 517502 4952 90105986
Frustration tolerance decreased 11.51 9.98 17 517492 7879 90103059
Nephrolithiasis 11.48 9.98 204 517305 48881 90062057
Bundle branch block left 11.47 9.98 17 517492 7868 90103070
Retinopathy 11.46 9.98 3 517506 3531 90107407
Oesophagitis 11.45 9.98 55 517454 17194 90093744
Cholelithiasis 11.42 9.98 221 517288 52285 90058653
Breakthrough pain 11.41 9.98 25 517484 1382 90109556
Gastrointestinal toxicity 11.40 9.98 23 517486 9444 90101494
Cytomegalovirus viraemia 11.38 9.98 16 517493 7570 90103368
Angiokeratoma 11.38 9.98 8 517501 129 90110809
Accidental poisoning 11.37 9.98 20 517489 940 90109998
Hallucination, synaesthetic 11.34 9.98 6 517503 56 90110882
Leukopenia neonatal 11.30 9.98 5 517504 30 90110908
Wrong technique in device usage process 11.28 9.98 10 517499 5825 90105113
Pharyngeal swelling 11.28 9.98 25 517484 9919 90101019
Gastritis 11.27 9.98 169 517340 41584 90069354
Central nervous system stimulation 11.25 9.98 6 517503 57 90110881
Tenosynovitis 11.23 9.98 130 517379 14437 90096501
Herpes simplex 11.22 9.98 26 517483 10155 90100783
Substance dependence 11.21 9.98 9 517500 179 90110759
Delayed haemolytic transfusion reaction 11.21 9.98 4 517505 12 90110926
Blood pressure diastolic increased 11.20 9.98 37 517472 12869 90098069
Throat clearing 11.16 9.98 4 517505 3843 90107095
Injection site inflammation 11.15 9.98 6 517503 4535 90106403
Ataxia 11.14 9.98 59 517450 17983 90092955
Staphylococcal infection 11.12 9.98 202 517307 48237 90062701
Disturbance in social behaviour 11.09 9.98 5 517504 4183 90106755
Increased tendency to bruise 11.09 9.98 33 517476 11857 90099081
Mandibular mass 11.09 9.98 9 517500 182 90110756
Suicidal ideation 11.05 9.98 329 517180 73526 90037412
Iron deficiency 11.03 9.98 24 517485 9588 90101350
Leukoencephalopathy 10.99 9.98 56 517453 4817 90106121
Counterfeit product administered 10.99 9.98 7 517502 95 90110843
Myoclonus 10.98 9.98 162 517347 19006 90091932
Human herpesvirus 6 infection 10.97 9.98 3 517506 3429 90107509
Blood urine present 10.95 9.98 56 517453 17222 90093716
Visual impairment 10.94 9.98 631 516878 131734 89979204
Muscle twitching 10.94 9.98 87 517422 24115 90086823
Face oedema 10.92 9.98 83 517426 23235 90087703
Restlessness 10.92 9.98 141 517368 35579 90075359
Dizziness postural 10.90 9.98 22 517487 9031 90101907
Lung cancer metastatic 10.88 9.98 39 517470 2872 90108066
Reversible cerebral vasoconstriction syndrome 10.83 9.98 5 517504 4125 90106813
Foot operation 10.73 9.98 22 517487 8979 90101959
Clostridium difficile colitis 10.73 9.98 99 517410 26607 90084331
Porphyria acute 10.72 9.98 153 517356 17822 90093116
Posterior reversible encephalopathy syndrome 10.71 9.98 79 517430 22260 90088678
Urosepsis 10.71 9.98 74 517435 21158 90089780
Psychiatric symptom 10.69 9.98 15 517494 7103 90103835
Orthopnoea 10.68 9.98 14 517495 6821 90104117
Acute graft versus host disease in skin 10.67 9.98 7 517502 4749 90106189
International normalised ratio increased 10.64 9.98 198 517311 47118 90063820
Polyp 10.62 9.98 17 517492 7627 90103311
Central nervous system injury 10.59 9.98 8 517501 145 90110793
Renal mass 10.54 9.98 35 517474 2480 90108458
Injection site discomfort 10.53 9.98 11 517498 5929 90105009
Pain in extremity 10.52 9.98 2344 515165 448185 89662753
Internal haemorrhage 10.50 9.98 12 517497 6208 90104730
Ear discomfort 10.49 9.98 27 517482 10173 90100765
Symptom masked 10.48 9.98 20 517489 1001 90109937
Spinal cord operation 10.45 9.98 3 517506 3 90110935
Lactobacillus infection 10.45 9.98 7 517502 104 90110834
Therapeutic product effect increased 10.45 9.98 23 517486 1276 90109662
Haemorrhoidal haemorrhage 10.44 9.98 9 517500 5314 90105624
Eye haemorrhage 10.43 9.98 27 517482 10153 90100785
Infusion site pruritus 10.42 9.98 14 517495 6751 90104187
Infusion site bruising 10.41 9.98 6 517503 4366 90106572
Opiates positive 10.40 9.98 11 517498 315 90110623
Hepatomegaly 10.37 9.98 40 517469 13286 90097652
Autoimmune thyroiditis 10.35 9.98 11 517498 5882 90105056
Ketoacidosis 10.33 9.98 10 517499 5585 90105353
Head injury 10.33 9.98 121 517388 31067 90079871
Diffuse cutaneous mastocytosis 10.31 9.98 5 517504 38 90110900
Galactorrhoea 10.31 9.98 7 517502 4665 90106273
Flatulence 10.30 9.98 170 517339 41197 90069741
Vitreous floaters 10.29 9.98 17 517492 7532 90103406
Cytokine release syndrome 10.27 9.98 106 517403 27867 90083071
Syringe issue 10.26 9.98 5 517504 3997 90106941
Skin laceration 10.25 9.98 97 517412 25938 90085000
Hepatic necrosis 10.25 9.98 13 517496 6425 90104513
Middle insomnia 10.22 9.98 55 517454 16696 90094242
Menstruation irregular 10.22 9.98 19 517490 8041 90102897
Laryngitis 10.20 9.98 370 517139 50383 90060555
Menstrual disorder 10.19 9.98 12 517497 6126 90104812
Left ventricular failure 10.19 9.98 14 517495 6686 90104252
Tendon disorder 10.19 9.98 14 517495 6686 90104252
Lip oedema 10.17 9.98 7 517502 4632 90106306
Right ventricular failure 10.15 9.98 66 517443 19139 90091799
Tension headache 10.15 9.98 17 517492 7492 90103446
Bronchial secretion retention 10.08 9.98 4 517505 3611 90107327
Hypothalamic pituitary adrenal axis suppression 10.07 9.98 11 517498 327 90110611
Haemorrhagic diathesis 10.06 9.98 10 517499 5514 90105424
Herpes virus infection 10.05 9.98 13 517496 6371 90104567
Metabolic disorder 10.02 9.98 17 517492 7453 90103485

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2516.06 10.75 2737 192935 102034 42323629
Drug abuser 2204.98 10.75 766 194906 2765 42422898
Drug dependence 1954.44 10.75 1369 194303 27725 42397938
Toxicity to various agents 1185.59 10.75 2981 192691 226155 42199508
Completed suicide 957.56 10.75 1643 194029 94822 42330841
Drug withdrawal syndrome 881.46 10.75 756 194916 20793 42404870
Overdose 658.92 10.75 1477 194195 103787 42321876
Inadequate analgesia 641.35 10.75 307 195365 2890 42422773
Respiratory arrest 607.16 10.75 700 194972 27724 42397939
Substance abuse 571.86 10.75 408 195264 8497 42417166
Off label use 417.85 10.75 1520 194152 636815 41788848
Accidental overdose 414.70 10.75 578 195094 27752 42397911
Miosis 317.52 10.75 349 195323 13097 42412566
Respiratory depression 300.37 10.75 401 195271 18467 42407196
Delirium 293.08 10.75 705 194967 51814 42373849
Constipation 282.90 10.75 1481 194191 160810 42264853
Cardio-respiratory arrest 281.11 10.75 743 194929 57893 42367770
Death 259.40 10.75 3298 192374 467887 41957776
Somnolence 245.35 10.75 1287 194385 139818 42285845
Intentional product misuse 214.75 10.75 699 194973 61201 42364462
Malignant neoplasm progression 203.20 10.75 1010 194662 107390 42318273
Nausea 180.57 10.75 2686 192986 394113 42031550
Unresponsive to stimuli 170.26 10.75 417 195255 30986 42394677
Toxic leukoencephalopathy 168.02 10.75 77 195595 650 42425013
Plasma cell myeloma 162.05 10.75 534 195138 47044 42378619
Confusional state 152.49 10.75 1301 194371 166296 42259367
Drug ineffective 151.28 10.75 2015 193657 628182 41797481
Product use in unapproved indication 150.36 10.75 396 195276 184060 42241603
Drug tolerance 148.00 10.75 122 195550 3168 42422495
Poisoning 144.97 10.75 250 195422 14449 42411214
Coma 138.93 10.75 550 195122 53004 42372659
Cardiac arrest 136.23 10.75 914 194758 108406 42317257
Drug screen positive 135.40 10.75 128 195544 4003 42421660
C-reactive protein abnormal 132.56 10.75 187 195485 9074 42416589
Exposure via ingestion 119.86 10.75 90 195582 2032 42423631
Withdrawal syndrome 106.74 10.75 220 195452 14555 42411108
Depressed level of consciousness 106.68 10.75 470 195202 47500 42378163
Depression 94.17 10.75 851 194821 110512 42315151
Hyperaesthesia 92.41 10.75 125 195547 5827 42419836
Drug resistance 92.01 10.75 22 195650 34226 42391437
Mental status changes 90.90 10.75 409 195263 41706 42383957
Narcotic bowel syndrome 88.74 10.75 31 195641 114 42425549
Drug use disorder 86.91 10.75 164 195508 10169 42415494
Myelosuppression 84.39 10.75 40 195632 40421 42385242
Respiratory rate decreased 81.15 10.75 83 195589 2862 42422801
Accidental death 79.76 10.75 84 195588 2999 42422664
Bradypnoea 78.70 10.75 99 195573 4294 42421369
Sedation 78.21 10.75 312 195360 30163 42395500
COVID-19 77.86 10.75 272 195400 115676 42309987
Cytomegalovirus infection 77.08 10.75 26 195646 32280 42393383
Terminal state 76.58 10.75 98 195574 4325 42421338
Cardiogenic shock 76.24 10.75 34 195638 35606 42390057
Cardiac failure 75.62 10.75 245 195427 106611 42319052
Asthma 74.92 10.75 106 195566 62208 42363455
Deep vein thrombosis 73.90 10.75 605 195067 76352 42349311
Lactic acidosis 73.32 10.75 60 195612 45201 42380462
Drug diversion 69.83 10.75 48 195624 939 42424724
Decreased appetite 69.08 10.75 1258 194414 191879 42233784
Sickle cell anaemia with crisis 68.89 10.75 98 195574 4792 42420871
Hyperhidrosis 68.67 10.75 676 194996 89836 42335827
Injection site pain 67.83 10.75 100 195572 57698 42367965
Delusional disorder, unspecified type 67.41 10.75 43 195629 738 42424925
Road traffic accident 67.41 10.75 217 195455 18876 42406787
Drug reaction with eosinophilia and systemic symptoms 66.64 10.75 57 195615 42018 42383645
Drug tolerance increased 65.97 10.75 35 195637 417 42425246
Dependence 64.74 10.75 54 195618 1426 42424237
Cough 61.62 10.75 522 195150 177581 42248082
Therapeutic product effect incomplete 61.03 10.75 148 195524 70791 42354872
Condition aggravated 60.93 10.75 837 194835 259917 42165746
Back pain 60.72 10.75 951 194721 140825 42284838
Product use issue 60.01 10.75 168 195504 76583 42349080
Pain 59.83 10.75 1509 194163 243339 42182324
Angioedema 59.75 10.75 64 195608 42413 42383250
Neutropenia 58.51 10.75 609 195063 198822 42226841
Foetal exposure during pregnancy 58.35 10.75 79 195593 47232 42378431
Apparent death 57.76 10.75 78 195594 3630 42422033
Cancer pain 57.04 10.75 76 195596 3491 42422172
Drug ineffective for unapproved indication 57.02 10.75 77 195595 46086 42379577
Ventricular fibrillation 56.62 10.75 34 195638 30089 42395574
Tenosynovitis 55.96 10.75 87 195585 4608 42421055
Vomiting 55.80 10.75 1732 193940 287991 42137672
Medication error 54.47 10.75 298 195374 32856 42392807
Gun shot wound 54.21 10.75 42 195630 995 42424668
Enthesopathy 54.14 10.75 87 195585 4741 42420922
Amnestic disorder 53.64 10.75 27 195645 286 42425377
Toxicologic test abnormal 51.99 10.75 31 195641 469 42425194
Pulmonary thrombosis 51.92 10.75 117 195555 8231 42417432
Intestinal sepsis 51.90 10.75 36 195636 715 42424948
Breakthrough pain 51.60 10.75 33 195639 569 42425094
Lethargy 51.29 10.75 380 195292 46510 42379153
Paroxysmal sympathetic hyperactivity 51.27 10.75 17 195655 51 42425612
Hypopnoea 50.74 10.75 112 195560 7770 42417893
Neuroleptic malignant syndrome 49.99 10.75 18 195654 21454 42404209
Product complaint 49.19 10.75 94 195578 5883 42419780
Epilepsy 48.54 10.75 30 195642 26141 42399522
Myasthenia gravis 48.29 10.75 8 195664 16129 42409534
Product dose omission issue 47.90 10.75 465 195207 153900 42271763
Tongue disorder 47.22 10.75 87 195585 5296 42420367
Eosinophilia 46.90 10.75 49 195623 32850 42392813
Pruritus 45.47 10.75 602 195070 188169 42237494
Drug interaction 44.66 10.75 911 194761 266088 42159575
Acute kidney injury 44.39 10.75 1316 194356 366021 42059642
Anxiety 44.00 10.75 777 194895 117783 42307880
Loss of consciousness 43.58 10.75 630 195042 91724 42333939
Counterfeit product administered 43.57 10.75 23 195649 271 42425392
Joint arthroplasty 43.47 10.75 36 195636 941 42424722
Multiple organ dysfunction syndrome 43.44 10.75 264 195408 96771 42328892
Impaired driving ability 42.78 10.75 60 195612 2895 42422768
Toxic epidermal necrolysis 42.65 10.75 36 195636 26714 42398949
Myoclonus 41.62 10.75 172 195500 16893 42408770
Decerebrate posture 41.32 10.75 18 195654 133 42425530
Emotional distress 40.68 10.75 164 195508 15929 42409734
Leukopenia 40.31 10.75 191 195481 74555 42351108
Blood phosphorus increased 40.30 10.75 5 195667 12520 42413143
Bone pain 39.86 10.75 215 195457 23577 42402086
Aspergillus infection 39.10 10.75 12 195660 15825 42409838
Haematotoxicity 38.97 10.75 3 195669 10982 42414681
Obstructive airways disorder 38.65 10.75 34 195638 24725 42400938
Pupillary reflex impaired 38.42 10.75 43 195629 1646 42424017
Septic shock 38.17 10.75 255 195417 91417 42334246
Foreign body reaction 38.04 10.75 14 195658 62 42425601
Transplant rejection 37.96 10.75 8 195664 13580 42412083
Disease recurrence 37.16 10.75 49 195623 29629 42396034
Lower respiratory tract infection 37.01 10.75 84 195588 41122 42384541
Sleep disorder due to a general medical condition 36.78 10.75 17 195655 17436 42408227
Serotonin syndrome 36.39 10.75 223 195449 25622 42400041
Atrial fibrillation 34.39 10.75 443 195229 139150 42286513
Nasopharyngitis 33.80 10.75 236 195436 83760 42341903
Alcohol poisoning 33.27 10.75 93 195579 7481 42418182
Drug hypersensitivity 33.25 10.75 641 195031 98748 42326915
Hypogammaglobulinaemia 33.22 10.75 7 195665 11884 42413779
Aplastic anaemia 33.17 10.75 8 195664 12376 42413287
Burns second degree 33.08 10.75 81 195591 6015 42419648
Hallucination 32.79 10.75 406 195266 57101 42368562
Thrombocytopenia 32.75 10.75 646 195026 189633 42236030
Respiratory tract infection 32.41 10.75 44 195628 26278 42399385
Gingival pain 32.24 10.75 99 195573 8395 42417268
Renal impairment 32.12 10.75 337 195335 109891 42315772
Parosmia 31.42 10.75 92 195580 7599 42418064
Pulmonary embolism 30.88 10.75 743 194929 118869 42306794
Catarrh 30.86 10.75 78 195594 5908 42419755
Cerebral haemorrhage 30.66 10.75 85 195587 38881 42386782
Formication 30.38 10.75 42 195630 1999 42423664
Urinary retention 29.93 10.75 311 195361 41903 42383760
Compartment syndrome 29.92 10.75 54 195618 3235 42422428
Drug detoxification 29.92 10.75 20 195652 373 42425290
Schizophrenia 29.91 10.75 6 195666 10544 42415119
Diabetes mellitus 29.84 10.75 158 195514 59929 42365734
Feeling abnormal 29.79 10.75 468 195204 69318 42356345
BK virus infection 29.54 10.75 3 195669 8781 42416882
Pathogen resistance 29.51 10.75 8 195664 11442 42414221
Therapy partial responder 29.47 10.75 29 195643 19992 42405671
Spinal fracture 29.36 10.75 101 195571 9089 42416574
No adverse event 29.33 10.75 87 195585 38934 42386729
Weight increased 29.12 10.75 336 195336 107647 42318016
Intervertebral disc degeneration 29.03 10.75 87 195585 7280 42418383
Nephropathy toxic 28.94 10.75 21 195651 16817 42408846
COVID-19 pneumonia 28.82 10.75 34 195638 21579 42404084
Impaired work ability 28.81 10.75 121 195551 11970 42413693
Melaena 28.68 10.75 87 195585 38659 42387004
Blood uric acid increased 28.59 10.75 18 195654 15529 42410134
Hepatic pain 28.57 10.75 36 195636 1564 42424099
Post transplant lymphoproliferative disorder 28.48 10.75 4 195668 9116 42416547
Piloerection 28.29 10.75 17 195655 261 42425402
Opiates positive 28.26 10.75 22 195650 525 42425138
Productive cough 28.25 10.75 131 195541 51436 42374227
Back injury 28.23 10.75 62 195610 4286 42421377
Hypoaesthesia 28.17 10.75 473 195199 70990 42354673
Seizure 28.09 10.75 387 195285 120174 42305489
Arthropathy 28.02 10.75 232 195440 29365 42396298
Alanine aminotransferase abnormal 27.15 10.75 66 195606 4878 42420785
Neoplasm malignant 26.99 10.75 188 195484 22555 42403108
Hyperphosphataemia 26.89 10.75 13 195659 12991 42412672
Drug screen negative 26.67 10.75 15 195657 202 42425461
Cytomegalovirus infection reactivation 26.66 10.75 9 195663 11169 42414494
Lip swelling 26.46 10.75 29 195643 19024 42406639
Wheezing 26.13 10.75 146 195526 54635 42371028
Sopor 26.10 10.75 14 195658 13188 42412475
Irritability 25.84 10.75 219 195453 27909 42397754
Intestinal pseudo-obstruction 25.79 10.75 41 195631 2214 42423449
Circulatory collapse 25.72 10.75 43 195629 23593 42402070
Rib fracture 25.26 10.75 146 195526 16425 42409238
Nervousness 25.24 10.75 126 195546 13406 42412257
Nodule 25.21 10.75 13 195659 12521 42413142
Deafness neurosensory 24.99 10.75 54 195618 3692 42421971
Drug-induced liver injury 24.85 10.75 91 195581 38182 42387481
Proteinuria 24.84 10.75 42 195630 22941 42402722
Intentional overdose 24.65 10.75 352 195320 51104 42374559
Dental caries 24.61 10.75 63 195609 4809 42420854
Substance dependence 24.59 10.75 22 195650 640 42425023
Small intestinal obstruction 24.52 10.75 148 195524 16913 42408750
Full blood count abnormal 24.39 10.75 64 195608 29812 42395851
Apnoea 24.27 10.75 85 195587 7718 42417945
Steroid dependence 24.27 10.75 77 195595 6645 42419018
Cardiac failure chronic 24.20 10.75 7 195665 9594 42416069
Acute myocardial infarction 24.10 10.75 162 195510 58003 42367660
Psoriasis 24.02 10.75 128 195544 48476 42377187
Carbon dioxide abnormal 24.00 10.75 16 195656 297 42425366
Syncope 23.90 10.75 317 195355 99089 42326574
Compression fracture 23.89 10.75 53 195619 3689 42421974
Bradycardia 23.83 10.75 264 195408 85220 42340443
Hypercalcaemia 23.67 10.75 153 195519 17905 42407758
Subarachnoid haemorrhage 23.66 10.75 19 195653 14453 42411210
Pulmonary alveolar haemorrhage 23.54 10.75 20 195652 14796 42410867
Neutrophil count increased 23.49 10.75 34 195638 19770 42405893
Brain injury 23.48 10.75 83 195589 7572 42418091
Cardiac failure acute 23.44 10.75 17 195655 13616 42412047
Injection site swelling 23.39 10.75 26 195646 16947 42408716
Yawning 23.31 10.75 23 195649 759 42424904
Device leakage 23.30 10.75 9 195663 10276 42415387
Postmortem blood drug level abnormal 23.29 10.75 17 195655 367 42425296
Stomatitis 23.20 10.75 342 195330 49987 42375676
Iron deficiency 22.96 10.75 11 195661 11050 42414613
Appendicitis 22.90 10.75 37 195635 20576 42405087
Angina pectoris 22.85 10.75 76 195596 32820 42392843
Cardiac failure congestive 22.83 10.75 267 195405 85335 42340328
Anaphylactic shock 22.73 10.75 46 195626 23471 42402192
Red blood cell sedimentation rate increased 22.63 10.75 98 195574 9826 42415837
Renal cell carcinoma 22.54 10.75 66 195606 5451 42420212
Febrile neutropenia 22.43 10.75 665 195007 185038 42240625
Forced expiratory volume decreased 22.35 10.75 4 195668 7626 42418037
Tooth loss 22.33 10.75 55 195617 4099 42421564
Tachyphylaxis 22.33 10.75 12 195660 147 42425516
Diabetic ketoacidosis 22.26 10.75 43 195629 22324 42403339
Transaminases increased 22.14 10.75 77 195595 32808 42392855
Nasal necrosis 22.09 10.75 9 195663 55 42425608
Lumbar radiculopathy 22.04 10.75 23 195649 812 42424851
Normochromic normocytic anaemia 22.01 10.75 7 195665 9024 42416639
Lymphopenia 21.86 10.75 41 195631 21522 42404141
Hypoglycaemia 21.77 10.75 173 195499 59681 42365982
Self-medication 21.69 10.75 47 195625 3219 42422444
Thermophobia 21.57 10.75 9 195663 59 42425604
Blood creatinine increased 21.55 10.75 365 195307 109638 42316025
Post laminectomy syndrome 21.50 10.75 13 195659 202 42425461
Suspected suicide 21.47 10.75 70 195602 6129 42419534
Labelled drug-drug interaction medication error 21.33 10.75 24 195648 15558 42410105
Pathological fracture 21.32 10.75 63 195609 5230 42420433
Alcohol use 21.27 10.75 43 195629 2805 42422858
Toxic skin eruption 21.25 10.75 19 195653 13711 42411952
Environmental exposure 21.23 10.75 14 195658 255 42425408
Atrioventricular block complete 21.11 10.75 13 195659 11351 42414312
Product formulation issue 21.03 10.75 22 195650 779 42424884
Interstitial lung disease 21.03 10.75 490 195182 77972 42347691
Insomnia 20.87 10.75 700 194972 117553 42308110
Acute chest syndrome 20.69 10.75 25 195647 1040 42424623
Disorganised speech 20.68 10.75 29 195643 1399 42424264
Respiratory acidosis 20.60 10.75 70 195602 6261 42419402
Acute hepatic failure 20.55 10.75 29 195643 17044 42408619
Device issue 20.55 10.75 19 195653 13490 42412173
Bronchopulmonary aspergillosis 20.54 10.75 36 195636 19393 42406270
Venoocclusive liver disease 20.26 10.75 11 195661 10291 42415372
Suspected counterfeit product 20.23 10.75 15 195657 332 42425331
Dysgeusia 20.19 10.75 243 195429 33946 42391717
Metastatic renal cell carcinoma 20.17 10.75 36 195636 2138 42423525
Aptyalism 20.12 10.75 16 195656 394 42425269
Pemphigoid 20.11 10.75 14 195658 11453 42414210
End stage renal disease 20.06 10.75 28 195644 16530 42409133
Nightmare 20.02 10.75 189 195483 24823 42400840
Agitation 19.90 10.75 410 195262 63904 42361759
Tendonitis 19.79 10.75 94 195578 9800 42415863
Agranulocytosis 19.73 10.75 73 195599 30539 42395124
Hepatotoxicity 19.72 10.75 55 195617 25112 42400551
Acute disseminated encephalomyelitis 19.57 10.75 11 195661 148 42425515
Pseudarthrosis 19.53 10.75 9 195663 77 42425586
Spinal fusion surgery 19.37 10.75 26 195646 1203 42424460
Chronic kidney disease 19.36 10.75 132 195540 47109 42378554
Neoplasm progression 19.31 10.75 211 195461 28789 42396874
Device programming error 19.23 10.75 10 195662 114 42425549
Anti factor V antibody 19.23 10.75 14 195658 301 42425362
Decubitus ulcer 19.15 10.75 97 195575 10380 42415283
Cytomegalovirus viraemia 19.10 10.75 12 195660 10365 42415298
Adenovirus infection 19.04 10.75 4 195668 6805 42418858
Dry eye 19.01 10.75 26 195646 15480 42410183
Acute graft versus host disease 18.93 10.75 7 195665 8208 42417455
Cyanosis 18.88 10.75 126 195546 14905 42410758
Inflammatory marker increased 18.83 10.75 4 195668 6752 42418911
Red blood cell sedimentation rate 18.81 10.75 24 195648 1056 42424607
Dehydration 18.77 10.75 813 194859 140954 42284709
Spinal cord ischaemia 18.77 10.75 9 195663 85 42425578
Gas poisoning 18.77 10.75 9 195663 85 42425578
Spinal operation 18.72 10.75 52 195620 4168 42421495
Haemodynamic instability 18.70 10.75 18 195654 12539 42413124
Loss of personal independence in daily activities 18.64 10.75 327 195345 49489 42376174
Parkinsonism 18.59 10.75 13 195659 10610 42415053
Syringe issue 18.55 10.75 8 195664 8548 42417115
Malignant catatonia 18.54 10.75 16 195656 443 42425220
Postoperative delirium 18.54 10.75 18 195654 582 42425081
Therapeutic response shortened 18.42 10.75 21 195651 13533 42412130
Cerebral infarction 18.39 10.75 77 195595 31092 42394571
Myelodysplastic syndrome 18.36 10.75 49 195623 22696 42402967
Accidental poisoning 18.29 10.75 26 195646 1270 42424393
Brain death 18.29 10.75 42 195630 2992 42422671
Systemic lupus erythematosus 18.23 10.75 88 195584 9236 42416427
Inappropriate schedule of product administration 18.21 10.75 320 195352 95582 42330081
Dyspnoea exertional 18.21 10.75 145 195527 50003 42375660
Tumour pain 18.13 10.75 26 195646 1281 42424382
Sinus tachycardia 18.02 10.75 159 195513 20494 42405169
Chest discomfort 17.91 10.75 196 195476 63420 42362243
Accident 17.83 10.75 68 195604 6435 42419228
Red blood cell sedimentation rate abnormal 17.74 10.75 48 195624 3788 42421875
Decreased gait velocity 17.70 10.75 11 195661 180 42425483
Levator syndrome 17.55 10.75 4 195668 0 42425663
Lymphadenopathy 17.55 10.75 86 195586 33279 42392384
Conjunctivitis allergic 17.53 10.75 3 195669 5908 42419755
Myelopathy 17.40 10.75 40 195632 2851 42422812
Pancreatitis acute 17.37 10.75 87 195585 33477 42392186
Labelled drug-drug interaction issue 17.30 10.75 30 195642 1741 42423922
Granuloma skin 17.22 10.75 24 195648 1151 42424512
Signet-ring cell carcinoma 17.20 10.75 5 195667 8 42425655
Fungal infection 17.07 10.75 41 195631 19681 42405982
Hypertriglyceridaemia 16.93 10.75 13 195659 10113 42415550
Therapeutic product effect decreased 16.87 10.75 263 195409 38887 42386776
Tuberculosis 16.84 10.75 13 195659 10086 42415577
Pupil fixed 16.84 10.75 31 195641 1886 42423777
Extrapyramidal disorder 16.82 10.75 31 195641 16381 42409282
Foreign body aspiration 16.74 10.75 13 195659 309 42425354
Nasal congestion 16.72 10.75 74 195598 29427 42396236
Aplasia pure red cell 16.69 10.75 6 195666 7160 42418503
Myocarditis 16.68 10.75 39 195633 18899 42406764
Victim of homicide 16.65 10.75 11 195661 201 42425462
Progressive multifocal leukoencephalopathy 16.65 10.75 17 195655 11519 42414144
Confusion postoperative 16.62 10.75 10 195662 154 42425509
Mucormycosis 16.60 10.75 6 195666 7137 42418526
Product counterfeit 16.56 10.75 10 195662 155 42425508
Drug effective for unapproved indication 16.42 10.75 5 195667 6628 42419035
Gastrointestinal haemorrhage 16.42 10.75 333 195339 97393 42328270
Viral infection 16.27 10.75 51 195621 22432 42403231
Photosensitivity reaction 16.27 10.75 107 195565 12595 42413068
Anaphylactic reaction 16.26 10.75 122 195550 42621 42383042
Atrial septal defect 16.25 10.75 8 195664 7911 42417752
Failure to anastomose 16.23 10.75 11 195661 210 42425453
Pain in extremity 16.18 10.75 846 194826 149758 42275905
Blood pressure fluctuation 16.17 10.75 66 195606 26842 42398821
Kidney transplant rejection 16.04 10.75 10 195662 8673 42416990
Blood pressure systolic abnormal 15.97 10.75 3 195669 5525 42420138
Dyspnoea 15.96 10.75 1784 193888 440837 41984826
Injection site erythema 15.93 10.75 44 195628 20151 42405512
Colon gangrene 15.88 10.75 5 195667 12 42425651
Neutrophilia 15.83 10.75 3 195669 5489 42420174
Hospitalisation 15.76 10.75 243 195429 74087 42351576
Spinal cord injury 15.62 10.75 19 195653 796 42424867
Bone disorder 15.61 10.75 66 195606 6547 42419116
Immunosuppressant drug level increased 15.58 10.75 8 195664 7723 42417940
Allodynia 15.52 10.75 22 195650 1072 42424591
Hyponatraemia 15.51 10.75 351 195321 101111 42324552
Graft versus host disease 15.51 10.75 22 195650 12903 42412760
Musculoskeletal stiffness 15.46 10.75 180 195492 57585 42368078
Status epilepticus 15.46 10.75 30 195642 15548 42410115
Synovitis 15.26 10.75 123 195549 15444 42410219
Metabolic encephalopathy 15.22 10.75 56 195616 5209 42420454
Bacterial infection 15.16 10.75 71 195601 27808 42397855
Bladder cancer 15.10 10.75 35 195637 17012 42408651
Breath sounds abnormal 15.10 10.75 20 195652 12073 42413590
Vestibular ischaemia 15.08 10.75 5 195667 15 42425648
Failure to thrive 15.01 10.75 84 195588 9338 42416325
Anaemia 14.99 10.75 1096 194576 279182 42146481
Foetal growth restriction 14.99 10.75 3 195669 5280 42420383
Visceral oedema 14.99 10.75 7 195665 62 42425601
Aortic stenosis 14.91 10.75 11 195661 8734 42416929
Haemophagocytic lymphohistiocytosis 14.90 10.75 39 195633 18183 42407480
Pancreatic abscess 14.89 10.75 10 195662 188 42425475
Neuritis 14.85 10.75 5 195667 6215 42419448
Upper respiratory tract infection 14.82 10.75 123 195549 42050 42383613
Mania 14.71 10.75 16 195656 10531 42415132
Ejection fraction decreased 14.68 10.75 52 195620 22035 42403628
Poisoning deliberate 14.62 10.75 88 195584 10046 42415617
Blood alkaline phosphatase increased 14.59 10.75 226 195446 33371 42392292
Disturbance in attention 14.58 10.75 205 195467 29661 42396002
Immune reconstitution inflammatory syndrome 14.58 10.75 15 195657 10128 42415535
Non-small cell lung cancer 14.46 10.75 53 195619 4921 42420742
Lung cancer metastatic 14.45 10.75 38 195634 2948 42422715
Medical device pain 14.42 10.75 6 195666 39 42425624
Product storage error 14.35 10.75 18 195654 11122 42414541
Injection site mass 14.34 10.75 11 195661 8564 42417099
Eosinophil count increased 14.28 10.75 17 195655 10746 42414917
Stevens-Johnson syndrome 14.22 10.75 53 195619 22125 42403538
Infusion related reaction 14.21 10.75 195 195477 60611 42365052
Confabulation 14.18 10.75 9 195663 153 42425510
Eye pruritus 14.12 10.75 19 195653 11393 42414270
Drug level decreased 14.06 10.75 15 195657 9962 42415701
Back disorder 14.04 10.75 70 195602 7444 42418219
Dermatitis atopic 14.03 10.75 22 195650 12382 42413281
Spinal cord compression 14.00 10.75 47 195625 4177 42421486
Snoring 13.88 10.75 45 195627 3928 42421735
Pseudomonas infection 13.86 10.75 33 195639 15890 42409773
Face oedema 13.84 10.75 26 195646 13640 42412023
Bone marrow failure 13.79 10.75 92 195580 33001 42392662
Upper gastrointestinal haemorrhage 13.77 10.75 82 195590 30217 42395446
Spinal cord paralysis 13.65 10.75 8 195664 117 42425546
Treatment noncompliance 13.64 10.75 109 195563 37563 42388100
Ileus 13.56 10.75 141 195531 18998 42406665
Partial seizures 13.49 10.75 5 195667 5854 42419809
Incorrect dose administered 13.44 10.75 167 195505 52807 42372856
Spinal disorder 13.42 10.75 49 195623 4542 42421121
Influenza virus test positive 13.41 10.75 9 195663 169 42425494
Granulocytopenia 13.41 10.75 8 195664 7106 42418557
Spinal laminectomy 13.39 10.75 12 195660 350 42425313
Injection site reaction 13.35 10.75 33 195639 15688 42409975
Visual impairment 13.29 10.75 130 195542 42983 42382680
Eyelid ptosis 13.26 10.75 7 195665 6654 42419009
Myofascial pain syndrome 13.24 10.75 12 195660 355 42425308
Cardiotoxicity 13.17 10.75 9 195663 7436 42418227
Hand amputation 13.17 10.75 3 195669 0 42425663
Herpes zoster 13.08 10.75 251 195421 38626 42387037
Blood glucose increased 13.02 10.75 249 195423 73450 42352213
Neurological symptom 13.02 10.75 16 195656 9975 42415688
Blood triglycerides increased 13.01 10.75 34 195638 15862 42409801
Musculoskeletal chest pain 12.93 10.75 92 195580 11112 42414551
Influenza 12.93 10.75 204 195468 61971 42363692
Visceral pain 12.87 10.75 7 195665 88 42425575
Dizziness 12.79 10.75 978 194694 248276 42177387
Prostate cancer 12.78 10.75 137 195535 44506 42381157
Euglycaemic diabetic ketoacidosis 12.75 10.75 5 195667 5655 42420008
Hypophagia 12.75 10.75 184 195488 26772 42398891
Malnutrition 12.71 10.75 112 195560 14430 42411233
Pulmonary congestion 12.66 10.75 119 195553 15611 42410052
Intervertebral disc disorder 12.65 10.75 28 195644 1946 42423717
Bronchospasm 12.63 10.75 25 195647 12860 42412803
Learning disability 12.59 10.75 12 195660 379 42425284
Therapeutic response decreased 12.54 10.75 109 195563 36903 42388760
General physical health deterioration 12.51 10.75 567 195105 150679 42274984
Knee arthroplasty 12.51 10.75 76 195596 8705 42416958
Rash erythematous 12.49 10.75 91 195581 32000 42393663
Chronic obstructive pulmonary disease 12.49 10.75 209 195463 62905 42362758
Rhinitis 12.49 10.75 96 195576 11881 42413782
Intraocular pressure increased 12.46 10.75 7 195665 6426 42419237
Needle issue 12.44 10.75 13 195659 8714 42416949
Vasculitis 12.43 10.75 43 195629 18351 42407312
Metastases to bone 12.40 10.75 113 195559 14696 42410967
Polyneuropathy 12.36 10.75 44 195628 18617 42407046
Myalgia 12.36 10.75 341 195331 95739 42329924
Injection site pruritus 12.32 10.75 15 195657 9390 42416273
Cataract 12.29 10.75 86 195586 30518 42395145
Pneumonia aspiration 12.29 10.75 309 195363 49769 42375894
Stent placement 12.27 10.75 53 195619 5307 42420356
Intervertebral disc protrusion 12.25 10.75 90 195582 10982 42414681
Device difficult to use 12.25 10.75 3 195669 4593 42421070
Sensory loss 12.23 10.75 52 195620 5172 42420491
Arthrofibrosis 12.22 10.75 6 195666 60 42425603
Generalised tonic-clonic seizure 12.20 10.75 71 195601 26308 42399355
Respiratory syncytial virus infection 12.19 10.75 9 195663 7143 42418520
Renal cancer metastatic 12.16 10.75 14 195658 553 42425110
Lymphangiosis carcinomatosa 12.06 10.75 19 195653 1018 42424645
Hypersensitivity 12.03 10.75 247 195425 72123 42353540
Convulsions local 11.95 10.75 5 195667 33 42425630
Oropharyngeal pain 11.95 10.75 131 195541 42379 42383284
Glomerular filtration rate decreased 11.89 10.75 37 195635 16314 42409349
Dysaesthesia 11.83 10.75 32 195640 2525 42423138
Hepatitis 11.83 10.75 75 195597 27225 42398438
Impaired quality of life 11.78 10.75 108 195564 14069 42411594
Facet joint syndrome 11.77 10.75 11 195661 339 42425324
Flank pain 11.77 10.75 67 195605 7496 42418167
Personality disorder 11.75 10.75 20 195652 1143 42424520
Hypertensive crisis 11.64 10.75 18 195654 10188 42415475
Concomitant disease aggravated 11.60 10.75 8 195664 6578 42419085
Atelectasis 11.60 10.75 138 195534 19223 42406440
Cardiac murmur 11.48 10.75 99 195573 12676 42412987
Lymphoma 11.44 10.75 31 195641 14290 42411373
Migraine 11.44 10.75 172 195500 25242 42400421
Faecaloma 11.42 10.75 58 195614 6212 42419451
Oesophageal spasm 11.40 10.75 14 195658 592 42425071
Diverticulitis 11.39 10.75 157 195515 22616 42403047
Artery dissection 11.38 10.75 10 195662 284 42425379
Adverse drug reaction 11.36 10.75 238 195434 37196 42388467
Blood parathyroid hormone decreased 11.32 10.75 24 195648 1619 42424044
Mucosal inflammation 11.30 10.75 159 195513 49215 42376448
Dry skin 11.30 10.75 155 195517 48183 42377480
Small for dates baby 11.29 10.75 5 195667 5258 42420405
Drug eruption 11.27 10.75 61 195611 23014 42402649
Escherichia infection 11.26 10.75 22 195650 11374 42414289
Coronary artery disease 11.26 10.75 176 195496 53544 42372119
Benign prostatic hyperplasia 11.22 10.75 54 195618 20998 42404665
Chemical burns of eye 11.19 10.75 4 195668 16 42425647
Diarrhoea 11.19 10.75 1903 193769 458946 41966717
Incorrect route of product administration 11.14 10.75 165 195507 24140 42401523
Tooth impacted 11.13 10.75 6 195666 74 42425589
Conjunctivitis 11.12 10.75 27 195645 12912 42412751
Infantile fibromatosis 11.10 10.75 3 195669 3 42425660
Lumbosacral plexopathy 11.10 10.75 3 195669 3 42425660
Victim of abuse 11.10 10.75 3 195669 3 42425660
Breath sounds absent 11.10 10.75 3 195669 3 42425660
Glycosylated haemoglobin increased 11.08 10.75 27 195645 12897 42412766
Ventricular tachycardia 11.04 10.75 87 195585 30073 42395590
Bone lesion 10.99 10.75 38 195634 3428 42422235
Arteriospasm coronary 10.98 10.75 4 195668 4734 42420929
Blood creatine phosphokinase increased 10.95 10.75 156 195516 48182 42377481
Victim of crime 10.92 10.75 13 195659 532 42425131
Metastases to spine 10.88 10.75 35 195637 3042 42422621
Meningitis streptococcal 10.85 10.75 6 195666 78 42425585
Purpura 10.84 10.75 24 195648 11855 42413808
Jaundice 10.79 10.75 104 195568 34485 42391178
Psychiatric decompensation 10.79 10.75 3 195669 4219 42421444
Pyrexia 10.78 10.75 1616 194056 392426 42033237
Tumour haemorrhage 10.78 10.75 39 195633 3599 42422064
Electrocardiogram QT prolonged 10.76 10.75 155 195517 47790 42377873

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 3395.38 10.10 4400 572566 173011 109839322
Completed suicide 2292.12 10.10 4346 572620 238035 109774298
Toxicity to various agents 1435.23 10.10 5624 571342 474931 109537402
Drug abuser 1262.65 10.10 600 576366 4809 110007524
Drug dependence 1218.92 10.10 1403 575563 48617 109963716
Respiratory arrest 1045.61 10.10 1402 575564 56897 109955436
Folliculitis 974.16 10.10 2473 574493 165180 109847153
Drug withdrawal syndrome 923.14 10.10 1065 575901 36989 109975344
Irritable bowel syndrome 887.00 10.10 2357 574609 161858 109850475
Muscle injury 859.92 10.10 2117 574849 138690 109873643
Impaired healing 734.45 10.10 2478 574488 194239 109818094
Off label use 670.75 10.10 4835 572131 1495350 108516983
Helicobacter infection 665.65 10.10 2276 574690 179601 109832732
Duodenal ulcer perforation 658.48 10.10 2233 574733 175467 109836866
Sleep disorder due to general medical condition, insomnia type 633.96 10.10 1578 575388 104065 109908268
Overdose 629.26 10.10 2652 574314 231142 109781191
Stomatitis 613.45 10.10 2914 574052 267328 109745005
Inadequate analgesia 574.86 10.10 348 576618 4729 110007604
Confusional state 561.38 10.10 4275 572691 464405 109547928
Cardio-respiratory arrest 528.29 10.10 1564 575402 114272 109898061
Lower respiratory tract infection 511.92 10.10 2566 574400 240540 109771793
Ill-defined disorder 505.52 10.10 1883 575083 154970 109857363
Blister 499.40 10.10 2429 574537 224947 109787386
Glossodynia 484.26 10.10 2367 574599 219637 109792696
Accidental overdose 471.10 10.10 915 576051 50919 109961414
Substance abuse 466.45 10.10 440 576526 12023 110000310
Pemphigus 463.18 10.10 2281 574685 212289 109800044
Cough 446.34 10.10 1102 575864 460539 109551794
Pericarditis 443.90 10.10 2288 574678 216826 109795507
Hand deformity 436.66 10.10 2273 574693 216233 109796100
Rheumatoid arthritis 436.05 10.10 2866 574100 296747 109715586
Systemic lupus erythematosus 430.28 10.10 2529 574437 251809 109760524
Wound 420.01 10.10 2367 574599 232070 109780263
Anti-cyclic citrullinated peptide antibody positive 397.99 10.10 1942 575024 180042 109832291
Respiratory depression 389.84 10.10 642 576324 31359 109980974
Synovitis 370.70 10.10 2575 574391 271517 109740816
Miosis 367.33 10.10 511 576455 21472 109990861
Drug ineffective 356.50 10.10 5690 571276 1514850 108497483
Injury 349.94 10.10 1838 575128 175427 109836906
Lip dry 343.89 10.10 1227 575739 98856 109913477
Delirium 341.74 10.10 1504 575462 133521 109878812
Facet joint syndrome 333.47 10.10 1188 575778 95640 109916693
Night sweats 332.74 10.10 1484 575482 132499 109879834
COVID-19 326.88 10.10 482 576484 244578 109767755
Fibromyalgia 316.91 10.10 1742 575224 169167 109843166
Injection site pain 303.55 10.10 288 576678 177634 109834699
Myelosuppression 283.88 10.10 71 576895 94269 109918064
Death 274.47 10.10 5144 571822 693725 109318608
Gastrointestinal disorder 270.33 10.10 2173 574793 239779 109772554
Therapeutic product effect decreased 269.59 10.10 2188 574778 242128 109770205
Joint range of motion decreased 269.05 10.10 1304 575662 120528 109891805
Bursitis 263.89 10.10 1358 575608 128560 109883773
Swelling 262.99 10.10 2895 574071 348146 109664187
Psoriatic arthropathy 262.64 10.10 1843 575123 194918 109817415
Hepatic enzyme increased 259.31 10.10 2687 574279 318205 109694128
Peripheral swelling 257.94 10.10 3231 573735 400803 109611530
Arthropathy 252.28 10.10 2449 574517 285073 109727260
C-reactive protein abnormal 251.94 10.10 1339 575627 128356 109883977
Product dose omission issue 243.46 10.10 861 576105 320921 109691412
Rheumatic fever 238.41 10.10 1266 575700 121313 109891020
Discomfort 234.77 10.10 1919 575047 212788 109799545
Peripheral venous disease 232.11 10.10 962 576004 83155 109929178
Intentional product misuse 230.03 10.10 1330 575636 131574 109880759
Cardiac arrest 228.47 10.10 1783 575183 194970 109817363
Type 2 diabetes mellitus 223.15 10.10 1637 575329 175595 109836738
Wound infection 219.12 10.10 1041 575925 95424 109916909
Drug interaction 215.68 10.10 1625 575341 498558 109513775
Joint swelling 209.37 10.10 3359 573607 439486 109572847
Neutropenia 209.24 10.10 1124 575842 373496 109638837
Weight increased 206.69 10.10 3205 573761 416439 109595894
Acute kidney injury 204.78 10.10 2223 574743 633207 109379126
Cardiac failure 203.77 10.10 420 576546 187206 109825127
Hyperaesthesia 203.51 10.10 313 576653 14414 109997919
Contraindicated product administered 203.38 10.10 2085 574881 246182 109766151
Angioedema 202.60 10.10 132 576834 98368 109913965
Road traffic accident 201.91 10.10 1099 575867 106299 109906034
Gait inability 199.61 10.10 1307 575659 135069 109877264
Sinusitis 198.04 10.10 2393 574573 294295 109718038
Toxic leukoencephalopathy 191.26 10.10 114 576852 1503 110010830
Drug screen positive 189.38 10.10 199 576767 6211 110006122
Drug resistance 186.81 10.10 34 576932 56340 109955993
Dry mouth 185.68 10.10 1724 575242 198224 109814109
Drug reaction with eosinophilia and systemic symptoms 172.99 10.10 107 576859 81988 109930345
Injection site erythema 171.94 10.10 143 576823 94033 109918300
Osteoarthritis 170.76 10.10 1577 575389 181046 109831287
Exposure via ingestion 168.27 10.10 165 576801 4735 110007598
Blood pressure increased 167.54 10.10 735 576231 257638 109754695
Breast cancer stage III 165.51 10.10 834 576132 78283 109934050
Infusion related reaction 162.41 10.10 2843 574123 378319 109634014
Cytomegalovirus infection 161.81 10.10 42 576924 54402 109957931
Drug ineffective for unapproved indication 160.05 10.10 180 576786 102658 109909675
Poisoning 157.18 10.10 418 576548 28687 109983646
Atrial fibrillation 156.44 10.10 641 576325 229001 109783332
Somnolence 155.33 10.10 2295 574671 295154 109717179
Medication error 154.29 10.10 1010 575956 104356 109907977
Injection site swelling 151.75 10.10 66 576900 61724 109950609
Unresponsive to stimuli 151.16 10.10 697 576269 63093 109949240
Back injury 149.22 10.10 565 576401 46834 109965499
Nail disorder 148.53 10.10 648 576318 57287 109955046
Prescribed overdose 147.97 10.10 871 576095 86710 109925623
Infection 146.30 10.10 2679 574287 359521 109652812
Accidental death 145.31 10.10 154 576812 4855 110007478
Influenza 143.38 10.10 430 576536 168671 109843662
Swollen joint count increased 141.98 10.10 833 576133 82828 109929505
Abdominal discomfort 140.33 10.10 2858 574108 391000 109621333
Liver injury 137.65 10.10 1293 575673 149120 109863213
Contusion 136.87 10.10 1838 575128 231523 109780810
Blepharospasm 135.69 10.10 607 576359 54244 109958089
Nasal congestion 135.22 10.10 189 576777 98093 109914240
Chest discomfort 134.19 10.10 461 576505 173387 109838946
Seizure 132.25 10.10 648 576318 220537 109791796
Device expulsion 132.23 10.10 7 576959 30884 109981449
Live birth 131.23 10.10 712 576254 68772 109943561
Rhinorrhoea 130.97 10.10 208 576758 102458 109909875
Lower limb fracture 130.96 10.10 755 576211 74593 109937740
Lactic acidosis 129.17 10.10 177 576789 92634 109919699
Anaemia 128.00 10.10 2045 574921 545041 109467292
Myalgia 127.54 10.10 661 576305 221720 109790613
Productive cough 127.38 10.10 252 576714 114053 109898280
Sleep disorder 126.32 10.10 1588 575378 197056 109815277
Syncope 125.38 10.10 586 576380 201950 109810383
Inflammation 125.11 10.10 1550 575416 191688 109820645
Obesity 124.29 10.10 1014 575952 112337 109899996
Musculoskeletal pain 123.68 10.10 1480 575486 181543 109830790
Hypotension 122.25 10.10 1959 575007 521890 109490443
Cardiogenic shock 121.82 10.10 74 576892 57264 109955069
Oropharyngeal pain 119.77 10.10 337 576629 134939 109877394
Cataract 119.50 10.10 143 576823 79342 109932991
Blood cholesterol increased 118.68 10.10 1480 575486 183305 109829028
Plasma cell myeloma 114.90 10.10 639 576327 62297 109950036
Nasopharyngitis 114.33 10.10 2779 574187 391582 109620751
Septic shock 113.44 10.10 430 576536 157098 109855235
Product label confusion 112.79 10.10 316 576650 22361 109989972
Multiple organ dysfunction syndrome 111.94 10.10 410 576556 151300 109861033
Erythema 111.64 10.10 977 575989 290470 109721863
Hypoaesthesia 111.49 10.10 2279 574687 311944 109700389
Lung disorder 110.51 10.10 1430 575536 178617 109833716
Deep vein thrombosis postoperative 108.24 10.10 602 576364 58689 109953644
Alopecia 108.04 10.10 2578 574388 362175 109650158
Febrile neutropenia 108.01 10.10 1093 575873 315674 109696659
Anaphylactic reaction 107.79 10.10 276 576690 114024 109898309
Taste disorder 107.70 10.10 646 576320 64741 109947592
Respiratory rate decreased 105.34 10.10 146 576820 6112 110006221
Renal impairment 105.33 10.10 565 576401 187880 109824453
Onychomadesis 104.56 10.10 494 576472 45169 109967164
Inappropriate schedule of product administration 104.40 10.10 628 576338 203009 109809324
Narcotic bowel syndrome 104.05 10.10 43 576923 236 110012097
C-reactive protein 103.40 10.10 371 576595 29960 109982373
Constipation 103.01 10.10 2519 574447 355267 109657066
Grip strength decreased 102.26 10.10 743 576223 79431 109932902
Autoimmune disorder 102.20 10.10 638 576328 64845 109947488
Cardiac failure congestive 101.86 10.10 423 576543 150577 109861756
Drug tolerance 101.80 10.10 250 576716 16335 109995998
Sopor 101.58 10.10 32 576934 36514 109975819
Condition aggravated 101.40 10.10 2989 573977 731847 109280486
Palpitations 100.70 10.10 457 576509 158755 109853578
Urticaria 100.39 10.10 2273 574693 316584 109695749
Depression 98.92 10.10 2259 574707 315076 109697257
Insomnia 97.67 10.10 2518 574448 358072 109654261
Diabetes mellitus 96.81 10.10 236 576730 99145 109913188
Hyponatraemia 96.09 10.10 702 576264 216951 109795382
Bradypnoea 95.37 10.10 166 576800 8483 110003850
Malignant neoplasm progression 95.04 10.10 1357 575609 173210 109839123
Drug intolerance 93.59 10.10 2780 574186 403732 109608601
Maternal exposure timing unspecified 93.15 10.10 281 576685 20732 109991601
Withdrawal syndrome 92.20 10.10 366 576600 31014 109981319
Intentional product use issue 91.90 10.10 1810 575156 246096 109766237
Mental status changes 91.71 10.10 696 576270 75426 109936907
Toxic epidermal necrolysis 90.79 10.10 97 576869 56630 109955703
Bradycardia 89.29 10.10 462 576504 155055 109857278
Drug use disorder 88.07 10.10 250 576716 17824 109994509
Hypercholesterolaemia 87.70 10.10 790 576176 90047 109922286
Abortion spontaneous 86.78 10.10 35 576931 34247 109978086
Aplastic anaemia 86.54 10.10 12 576954 24296 109988037
Hypersensitivity 86.38 10.10 2738 574228 401260 109611073
Aspergillus infection 85.85 10.10 15 576951 25601 109986732
Transplant rejection 85.43 10.10 13 576953 24554 109987779
Product quality issue 85.00 10.10 692 576274 76607 109935726
Angina pectoris 84.49 10.10 121 576845 62174 109950159
Injection site pruritus 83.89 10.10 86 576880 51172 109961161
Mobility decreased 81.88 10.10 1715 575251 235707 109776626
Swelling face 81.71 10.10 230 576736 92091 109920242
Urinary tract infection 81.18 10.10 1205 575761 325077 109687256
Melaena 78.85 10.10 149 576817 68608 109943725
Anaphylactic shock 78.27 10.10 92 576874 51454 109960879
Coma 78.23 10.10 950 576016 116919 109895414
Haematotoxicity 76.02 10.10 10 576956 21072 109991261
Flushing 75.98 10.10 285 576681 104451 109907882
Maternal exposure during pregnancy 75.57 10.10 1802 575164 253081 109759252
Injection site bruising 75.19 10.10 94 576872 51169 109961164
Full blood count abnormal 74.91 10.10 110 576856 55942 109956391
Respiratory tract infection 74.64 10.10 164 576802 71453 109940880
Adverse reaction 74.32 10.10 329 576637 29265 109983068
Sciatica 74.15 10.10 773 576193 91626 109920707
Depressed level of consciousness 74.10 10.10 904 576062 111374 109900959
Paraesthesia oral 73.59 10.10 42 576924 33629 109978704
Hypoglycaemia 73.57 10.10 333 576633 115771 109896562
Incorrect route of product administration 73.44 10.10 579 576387 63482 109948851
Eosinophilia 73.30 10.10 118 576848 57818 109954515
Therapy partial responder 73.08 10.10 52 576914 37009 109975324
Eye pruritus 72.90 10.10 40 576926 32735 109979598
Ear pain 72.37 10.10 501 576465 52725 109959608
Haemorrhage 71.25 10.10 300 576666 106392 109905941
COVID-19 pneumonia 70.80 10.10 54 576912 37089 109975244
Product use in unapproved indication 70.60 10.10 1785 575181 445592 109566741
Pregnancy 70.22 10.10 482 576484 50585 109961748
Finger deformity 70.01 10.10 350 576616 32742 109979591
Dyspnoea exertional 69.87 10.10 292 576674 103768 109908565
Leukopenia 69.52 10.10 472 576494 148319 109864014
Epistaxis 69.50 10.10 397 576569 129975 109882358
Mucosal inflammation 69.49 10.10 262 576704 95879 109916454
Skin exfoliation 68.59 10.10 231 576735 87420 109924913
Viral infection 68.39 10.10 107 576859 53032 109959301
Cerebral haemorrhage 68.34 10.10 148 576818 64820 109947513
Enthesopathy 68.18 10.10 180 576786 12298 110000035
Therapeutic response shortened 67.42 10.10 35 576931 29548 109982785
Myasthenia gravis 67.05 10.10 15 576951 21496 109990837
Sneezing 66.94 10.10 42 576924 31942 109980391
Blood glucose increased 66.64 10.10 411 576555 132085 109880248
Sickle cell anaemia with crisis 66.31 10.10 151 576815 9394 110002939
Illness 66.06 10.10 214 576752 81957 109930376
Pancytopenia 65.86 10.10 737 576229 208876 109803457
Counterfeit product administered 65.49 10.10 31 576935 246 110012087
Post transplant lymphoproliferative disorder 65.41 10.10 4 576962 15609 109996724
No adverse event 65.31 10.10 184 576782 73655 109938678
Epstein-Barr virus infection 64.97 10.10 10 576956 18728 109993605
Haematochezia 64.74 10.10 346 576620 115178 109897155
Gastrointestinal haemorrhage 63.72 10.10 554 576412 164964 109847369
Abdominal pain upper 63.22 10.10 2321 574645 346790 109665543
Device difficult to use 63.05 10.10 11 576955 18794 109993539
Disease recurrence 62.68 10.10 140 576826 60644 109951689
Agranulocytosis 62.26 10.10 144 576822 61616 109950717
Headache 61.94 10.10 3872 573094 878505 109133828
Premature delivery 61.70 10.10 42 576924 30590 109981743
Tenosynovitis 61.44 10.10 206 576760 16077 109996256
Cytomegalovirus infection reactivation 60.86 10.10 11 576955 18322 109994011
Throat irritation 60.57 10.10 117 576849 53435 109958898
Macular degeneration 60.13 10.10 19 576947 21640 109990693
Circulatory collapse 59.81 10.10 82 576884 42911 109969422
Lip swelling 59.69 10.10 108 576858 50559 109961774
Blood pressure fluctuation 59.36 10.10 196 576770 74628 109937705
Ventricular fibrillation 59.30 10.10 77 576889 41236 109971097
Rheumatoid factor positive 59.26 10.10 991 575975 130649 109881684
Dyspnoea 58.99 10.10 4973 571993 1101899 108910434
Pleural fibrosis 58.74 10.10 91 576875 4217 110008116
Presbyacusis 58.67 10.10 73 576893 2746 110009587
Orthostatic hypotension 58.66 10.10 165 576801 66084 109946249
Tongue disorder 58.55 10.10 186 576780 14112 109998221
Toxicologic test abnormal 58.44 10.10 51 576915 1256 110011077
Cancer pain 58.43 10.10 117 576849 6655 110005678
Transaminases increased 58.28 10.10 155 576811 63235 109949098
Drug tolerance increased 57.68 10.10 37 576929 560 110011773
Hepatotoxicity 57.55 10.10 156 576810 63244 109949089
Coeliac disease 57.25 10.10 404 576562 42783 109969550
Bronchitis 57.21 10.10 533 576433 156499 109855834
Drug dose omission by device 57.15 10.10 5 576961 14511 109997822
Thrombocytopenia 56.92 10.10 1385 575581 347500 109664833
Generalised tonic-clonic seizure 56.33 10.10 126 576840 54554 109957779
Haemophagocytic lymphohistiocytosis 55.07 10.10 50 576916 31509 109980824
Hypogammaglobulinaemia 55.05 10.10 18 576948 20058 109992275
Proteinuria 54.99 10.10 77 576889 39941 109972392
Stress 54.97 10.10 323 576643 105025 109907308
Onychomycosis 54.96 10.10 367 576599 38164 109974169
Neuroleptic malignant syndrome 54.77 10.10 58 576908 34001 109978332
Bacterial infection 54.35 10.10 98 576868 45938 109966395
Creatinine renal clearance decreased 54.04 10.10 23 576943 21792 109990541
Incorrect dose administered 53.95 10.10 318 576648 103323 109909010
Pathogen resistance 53.74 10.10 13 576953 17659 109994674
Subarachnoid haemorrhage 53.10 10.10 46 576920 29656 109982677
Delusional disorder, unspecified type 52.91 10.10 41 576925 850 110011483
Memory impairment 52.89 10.10 1374 575592 195570 109816763
Nasal necrosis 52.76 10.10 24 576942 172 110012161
Renal failure 52.51 10.10 848 576118 225726 109786607
Apparent death 52.32 10.10 70 576896 2832 110009501
Amnestic disorder 52.30 10.10 38 576928 712 110011621
Cardiotoxicity 52.16 10.10 12 576954 16869 109995464
Suspected suicide 51.88 10.10 186 576780 15013 109997320
Deafness neurosensory 51.79 10.10 138 576828 9481 110002852
Adverse event 51.52 10.10 826 576140 107983 109904350
Serotonin syndrome 51.36 10.10 503 576463 58650 109953683
Blood uric acid increased 51.29 10.10 24 576942 21505 109990828
Extrapyramidal disorder 51.26 10.10 45 576921 28822 109983511
Adjustment disorder with depressed mood 51.05 10.10 398 576568 43485 109968848
Forced expiratory volume decreased 50.64 10.10 5 576961 13171 109999162
Pneumocystis jirovecii pneumonia 50.43 10.10 91 576875 42644 109969689
Oesophageal motility disorder 50.41 10.10 38 576928 755 110011578
BK virus infection 50.30 10.10 5 576961 13101 109999232
Blood test abnormal 50.11 10.10 45 576921 28509 109983824
Device issue 49.94 10.10 64 576902 34471 109977862
Paroxysmal sympathetic hyperactivity 49.89 10.10 17 576949 48 110012285
Blood creatinine increased 49.87 10.10 663 576303 182226 109830107
Diarrhoea 49.79 10.10 5196 571770 1134309 108878024
Therapeutic product effect incomplete 49.78 10.10 844 576122 222961 109789372
Haematuria 49.68 10.10 243 576723 82762 109929571
Myelodysplastic syndrome 49.66 10.10 74 576892 37410 109974923
Inflammatory marker increased 49.54 10.10 8 576958 14461 109997872
Balance disorder 49.49 10.10 380 576586 116180 109896153
Dizziness 49.42 10.10 3061 573905 695132 109317201
Terminal state 49.01 10.10 98 576868 5569 110006764
Multiple-drug resistance 48.40 10.10 6 576960 13229 109999104
Cystitis 48.34 10.10 179 576787 65857 109946476
Status epilepticus 48.31 10.10 56 576910 31515 109980818
Wrong technique in product usage process 48.17 10.10 263 576703 87085 109925248
Acute myocardial infarction 48.01 10.10 249 576717 83528 109928805
Sinus disorder 48.01 10.10 60 576906 32668 109979665
Dependence 47.94 10.10 65 576901 2664 110009669
General physical health deterioration 47.79 10.10 2694 574272 422601 109589732
Muscle spasticity 47.62 10.10 336 576630 35579 109976754
Deep vein thrombosis 47.40 10.10 1008 575958 138879 109873454
Arrhythmia 46.85 10.10 195 576771 69380 109942953
Sleep disorder due to a general medical condition 46.72 10.10 129 576837 51983 109960350
Dry skin 46.63 10.10 349 576617 107304 109905029
Parkinsonism 46.62 10.10 29 576937 22158 109990175
Vasculitis 46.39 10.10 72 576894 35801 109976532
Migraine 45.92 10.10 1197 575769 170455 109841878
Decreased appetite 45.74 10.10 2973 573993 472873 109539460
Wheezing 45.48 10.10 1694 575272 253536 109758797
Hemiparesis 45.36 10.10 101 576865 43802 109968531
Pancreatitis acute 45.03 10.10 162 576804 60112 109952221
Cognitive disorder 44.76 10.10 270 576696 87241 109925092
Drug diversion 44.67 10.10 45 576921 1335 110010998
Cardiac failure acute 44.64 10.10 36 576930 24042 109988291
Pupillary reflex impaired 44.19 10.10 77 576889 3938 110008395
Injection site haemorrhage 43.95 10.10 65 576901 32963 109979370
Pemphigoid 43.90 10.10 24 576942 19683 109992650
Obstructive airways disorder 43.84 10.10 111 576855 46038 109966295
Cardiac disorder 43.55 10.10 227 576739 76053 109936280
Malaise 43.17 10.10 2971 573995 668848 109343485
Chronic kidney disease 43.02 10.10 228 576738 76063 109936270
Lymphopenia 42.67 10.10 91 576875 40079 109972254
Hyperphosphataemia 42.66 10.10 16 576950 16365 109995968
Blood pressure decreased 42.63 10.10 389 576577 114702 109897631
Schizophrenia 42.54 10.10 31 576935 21795 109990538
Mouth ulceration 42.54 10.10 120 576846 48018 109964315
Cerebrovascular accident 42.50 10.10 677 576289 180607 109831726
Diabetic ketoacidosis 42.45 10.10 98 576868 41960 109970373
Salpingo-oophorectomy unilateral 42.43 10.10 35 576931 796 110011537
Hyperkalaemia 42.03 10.10 479 576487 135317 109877016
Progressive multifocal leukoencephalopathy 41.83 10.10 41 576925 24915 109987418
Injection site mass 41.76 10.10 40 576926 24573 109987760
Accidental exposure to product by child 41.45 10.10 66 576900 3132 110009201
Skin haemorrhage 41.37 10.10 41 576925 24786 109987547
Product dose omission in error 41.33 10.10 37 576929 23475 109988858
Injection site urticaria 41.31 10.10 19 576947 17196 109995137
Transient ischaemic attack 40.83 10.10 183 576783 63799 109948534
Device dislocation 40.65 10.10 64 576902 31640 109980693
Hyperthyroidism 40.51 10.10 56 576910 29205 109983128
Bronchopulmonary aspergillosis 40.50 10.10 58 576908 29805 109982528
Sinus congestion 40.48 10.10 60 576906 30399 109981934
Secretion discharge 40.45 10.10 28 576938 20216 109992117
Pneumonia 40.38 10.10 3982 572984 872732 109139601
Breath sounds abnormal 40.03 10.10 44 576922 25360 109986973
Vertigo 39.86 10.10 277 576689 86593 109925740
Atrioventricular block complete 39.83 10.10 28 576938 20054 109992279
Pleural thickening 39.80 10.10 67 576899 3332 110009001
X-ray abnormal 39.64 10.10 337 576629 37780 109974553
Therapeutic response decreased 39.38 10.10 318 576648 96181 109916152
Needle issue 39.35 10.10 22 576944 17818 109994515
Drug level decreased 39.31 10.10 24 576942 18524 109993809
Blood phosphorus increased 39.26 10.10 18 576948 16322 109996011
Oral candidiasis 39.24 10.10 112 576854 44648 109967685
Gun shot wound 39.22 10.10 38 576928 1074 110011259
Stevens-Johnson syndrome 39.20 10.10 120 576846 46781 109965552
Blood magnesium increased 39.10 10.10 71 576895 3752 110008581
Red blood cell sedimentation rate 39.05 10.10 85 576881 5129 110007204
Iron deficiency 39.03 10.10 24 576942 18452 109993881
Myocardial infarction 39.02 10.10 736 576230 191347 109820986
Neutrophil count increased 38.94 10.10 76 576890 34576 109977757
Pulmonary arterial hypertension 38.74 10.10 69 576897 32499 109979834
Hemiplegia 38.68 10.10 37 576929 22745 109989588
Blood creatine phosphokinase increased 38.68 10.10 223 576743 72854 109939479
Hypertensive crisis 38.64 10.10 42 576924 24330 109988003
Muscle spasms 38.59 10.10 1798 575168 276359 109735974
Haemoglobin decreased 38.49 10.10 995 575971 247732 109764601
Ventricular tachycardia 38.30 10.10 133 576833 49876 109962457
Sputum discoloured 38.17 10.10 54 576912 27891 109984442
Rash papular 38.16 10.10 53 576913 27586 109984747
Gastrointestinal procedural complication 38.10 10.10 26 576940 439 110011894
Dislocation of vertebra 38.07 10.10 372 576594 43349 109968984
Bladder cancer 38.04 10.10 30 576936 20262 109992071
Nodule 38.04 10.10 70 576896 32561 109979772
Breakthrough pain 38.03 10.10 44 576922 1532 110010801
Glaucoma 37.74 10.10 37 576929 22480 109989853
Haemoptysis 37.63 10.10 218 576748 71136 109941197
Psoriasis 37.61 10.10 509 576457 139484 109872849
Granulocytopenia 37.42 10.10 10 576956 12705 109999628
Immune reconstitution inflammatory syndrome 37.27 10.10 19 576947 16207 109996126
Intraocular pressure increased 37.26 10.10 6 576960 10870 110001463
Compartment syndrome 37.25 10.10 90 576876 5820 110006513
Pain 37.15 10.10 5600 571366 949355 109062978
Myoclonus 37.13 10.10 297 576669 32701 109979632
Heart rate increased 36.85 10.10 528 576438 143306 109869027
Vaginal discharge 36.81 10.10 24 576942 17884 109994449
Cardiac failure chronic 36.80 10.10 13 576953 13798 109998535
Rales 36.66 10.10 45 576921 24694 109987639
Oral herpes 36.47 10.10 84 576882 35996 109976337
Liver function test increased 36.39 10.10 657 576309 87891 109924442
End stage renal disease 36.32 10.10 35 576931 21438 109990895
Mucormycosis 36.11 10.10 6 576960 10622 110001711
Alanine aminotransferase abnormal 36.03 10.10 119 576847 9215 110003118
Dysphonia 35.89 10.10 240 576726 75689 109936644
Tachycardia 35.78 10.10 904 576062 225741 109786592
Glomerular filtration rate decreased 35.67 10.10 60 576906 28896 109983437
Ischaemic stroke 35.62 10.10 104 576862 41159 109971174
Multiple sclerosis relapse 35.60 10.10 138 576828 50102 109962231
Purpura 35.47 10.10 45 576921 24343 109987990
Acute lung injury 35.42 10.10 61 576905 3090 110009243
Rash maculo-papular 35.39 10.10 234 576732 73988 109938345
Injection site rash 35.34 10.10 42 576924 23377 109988956
Myopathy 35.33 10.10 47 576919 24913 109987420
Polyneuropathy 35.29 10.10 71 576895 31941 109980392
Bronchospasm 35.13 10.10 65 576901 30174 109982159
Cerebral infarction 35.08 10.10 145 576821 51693 109960640
Breast cancer stage II 35.07 10.10 254 576712 27121 109985212
Cytomegalovirus viraemia 34.93 10.10 25 576941 17739 109994594
Eosinophil count increased 34.83 10.10 35 576931 21023 109991310
Chronic obstructive pulmonary disease 34.59 10.10 383 576583 108775 109903558
Foreign body reaction 34.56 10.10 18 576948 179 110012154
Acute graft versus host disease in skin 34.48 10.10 7 576959 10733 110001600
Device malfunction 34.30 10.10 50 576916 25508 109986825
Pallor 33.97 10.10 165 576801 56302 109956031
Accidental exposure to product 33.76 10.10 140 576826 49868 109962465
Rash erythematous 33.70 10.10 269 576697 81563 109930770
Presyncope 33.55 10.10 136 576830 48751 109963582
Drug effective for unapproved indication 33.43 10.10 16 576950 14151 109998182
Upper gastrointestinal haemorrhage 33.36 10.10 141 576825 49955 109962378
Velopharyngeal incompetence 33.21 10.10 9 576957 7 110012326
Ocular hyperaemia 33.21 10.10 100 576866 39186 109973147
Cholecystitis chronic 33.06 10.10 117 576849 9383 110002950
Proctitis 33.05 10.10 24 576942 16903 109995430
Poisoning deliberate 32.98 10.10 243 576723 26088 109986245
Chronic graft versus host disease 32.89 10.10 5 576961 9452 110002881
Dysphagia 32.62 10.10 584 576382 153016 109859317
Device leakage 32.33 10.10 22 576944 16026 109996307
Therapy interrupted 32.09 10.10 142 576824 49680 109962653
Hypomagnesaemia 32.07 10.10 184 576782 60186 109952147
Cardiovascular disorder 32.07 10.10 43 576923 22717 109989616
Caesarean section 32.00 10.10 16 576950 13801 109998532
Osteosclerosis 32.00 10.10 72 576894 4443 110007890
Eczema 31.96 10.10 233 576733 72060 109940273
Thrombotic microangiopathy 31.83 10.10 65 576901 29084 109983249
Jaundice 31.76 10.10 180 576786 59056 109953277
Pulmonary alveolar haemorrhage 31.64 10.10 35 576931 20115 109992218
Dermatitis bullous 31.52 10.10 27 576939 17502 109994831
Pseudomonas infection 31.37 10.10 61 576905 27792 109984541
Acute graft versus host disease 31.24 10.10 14 576952 12867 109999466
Body temperature increased 31.24 10.10 429 576537 54284 109958049
Anosmia 31.14 10.10 13 576953 12459 109999874
Brain injury 31.00 10.10 146 576820 13330 109999003
Spinal cord ischaemia 30.96 10.10 18 576948 226 110012107
Heart rate decreased 30.95 10.10 279 576687 82477 109929856
Back disorder 30.88 10.10 201 576765 20721 109991612
Exposure via skin contact 30.79 10.10 15 576951 13132 109999201
Product storage error 30.67 10.10 41 576925 21687 109990646
Lethargy 30.64 10.10 671 576295 92905 109919428
Neutrophilia 30.63 10.10 8 576958 10321 110002012
Hypokalaemia 30.63 10.10 721 576245 181727 109830606
Psychotic disorder 30.55 10.10 149 576817 50788 109961545
Drug detoxification 30.52 10.10 25 576941 563 110011770
Treatment noncompliance 30.49 10.10 239 576727 72751 109939582
Hypopnoea 30.48 10.10 129 576837 11251 110001082
Electrocardiogram QT prolonged 30.42 10.10 393 576573 108567 109903766
Device breakage 30.34 10.10 17 576949 13752 109998581
Burns second degree 30.22 10.10 99 576867 7634 110004699
Hypomania 30.10 10.10 8 576958 10202 110002131
Complication of device insertion 30.00 10.10 5 576961 8833 110003500
Glycosylated haemoglobin increased 29.98 10.10 48 576918 23571 109988762
Subdural haematoma 29.95 10.10 94 576872 36360 109975973
Injection site warmth 29.87 10.10 28 576938 17377 109994956
Bone marrow failure 29.83 10.10 178 576788 57670 109954663
Aphthous ulcer 29.71 10.10 40 576926 21096 109991237
Aphasia 29.66 10.10 183 576783 58814 109953519
Catarrh 29.65 10.10 95 576871 7240 110005093
Asthma 29.62 10.10 1038 575928 249253 109763080
Torsade de pointes 29.57 10.10 45 576921 22555 109989778
Lymphadenopathy 29.56 10.10 203 576763 63632 109948701
Diabetes mellitus inadequate control 29.55 10.10 70 576896 29705 109982628
Liver disorder 29.55 10.10 961 576005 141282 109871051
Haemodynamic instability 29.54 10.10 46 576920 22842 109989491
Gamma-glutamyltransferase increased 29.37 10.10 193 576773 61116 109951217
Lung opacity 29.32 10.10 12 576954 11640 110000693
Visual acuity reduced 29.32 10.10 79 576887 32094 109980239
Infusion site reaction 29.31 10.10 175 576791 17507 109994826
Pain of skin 29.09 10.10 37 576929 19992 109992341
Respiratory acidosis 29.08 10.10 146 576820 13680 109998653
Pleural effusion 29.08 10.10 705 576261 177004 109835329
Fall 29.00 10.10 2732 574234 600750 109411583
Subcutaneous drug absorption impaired 28.99 10.10 97 576869 7562 110004771
Hypertriglyceridaemia 28.90 10.10 25 576941 16129 109996204
Tuberculosis 28.88 10.10 30 576936 17744 109994589
Hepatic steatosis 28.62 10.10 144 576822 48687 109963646
Conjunctivitis 28.57 10.10 86 576880 33706 109978627
Acne 28.56 10.10 85 576881 33435 109978898
Drug specific antibody present 28.13 10.10 5 576961 8429 110003904
Shock 28.11 10.10 164 576802 53424 109958909
Hepatic cytolysis 28.08 10.10 170 576796 54883 109957450
Partial seizures 28.06 10.10 12 576954 11337 110000996
Malignant melanoma 28.02 10.10 28 576938 16863 109995470
Upper respiratory tract infection 27.99 10.10 499 576467 130829 109881504
Sinus bradycardia 27.94 10.10 71 576895 29412 109982921
Eye disorder 27.86 10.10 69 576897 28837 109983496
Venoocclusive liver disease 27.86 10.10 23 576943 15184 109997149
Dermatitis atopic 27.85 10.10 57 576909 25484 109986849
Drug level below therapeutic 27.83 10.10 13 576953 11660 110000673
Suicide attempt 27.75 10.10 376 576590 103018 109909315
Heart rate irregular 27.73 10.10 89 576877 34185 109978148
Influenza like illness 27.69 10.10 311 576655 88101 109924232
Intestinal sepsis 27.60 10.10 30 576936 974 110011359
Coronary artery disease 27.56 10.10 240 576726 71450 109940883
Gout 27.50 10.10 98 576868 36468 109975865
Opiates positive 27.47 10.10 29 576937 910 110011423
Gingival bleeding 27.43 10.10 38 576928 19801 109992532
Aplasia pure red cell 27.32 10.10 8 576958 9570 110002763
Epilepsy 27.14 10.10 700 576266 99509 109912824
Lymphoproliferative disorder 27.07 10.10 3 576963 7215 110005118
SARS-CoV-2 test positive 27.05 10.10 29 576937 16906 109995427
Acute myeloid leukaemia 26.80 10.10 105 576861 38005 109974328
Uveitis 26.73 10.10 45 576921 21665 109990668
Injection site induration 26.64 10.10 13 576953 11370 110000963
Cytomegalovirus chorioretinitis 26.64 10.10 3 576963 7125 110005208
Acute hepatic failure 26.59 10.10 99 576867 36369 109975964
Adenovirus infection 26.59 10.10 12 576954 10982 110001351
Systemic infection 26.58 10.10 9 576957 9810 110002523
Arthritis 26.56 10.10 668 576298 166918 109845415
Infusion site pain 26.54 10.10 31 576935 17388 109994945
Blood pressure diastolic decreased 26.44 10.10 97 576869 35788 109976545
Vision blurred 26.31 10.10 494 576472 128528 109883805
Intentional dose omission 26.25 10.10 40 576926 20040 109992293
Colitis microscopic 26.14 10.10 19 576947 13375 109998958
Inappropriate antidiuretic hormone secretion 25.94 10.10 90 576876 33761 109978572
Soft tissue disorder 25.88 10.10 57 576909 3467 110008866
Adjustment disorder 25.77 10.10 12 576954 10783 110001550
Complications of transplanted kidney 25.74 10.10 4 576962 7438 110004895
Chronic sinusitis 25.68 10.10 58 576908 25026 109987307
Prostate cancer 25.65 10.10 105 576861 37536 109974797
Face oedema 25.64 10.10 89 576877 33380 109978953
Drug level increased 25.59 10.10 145 576821 47574 109964759
Immunosuppression 25.59 10.10 33 576933 17726 109994607
Blood pressure systolic increased 25.58 10.10 293 576673 82698 109929635
Neck pain 25.35 10.10 831 576135 122299 109890034
Therapy cessation 25.32 10.10 134 576832 44723 109967610
Mitral valve incompetence 25.28 10.10 89 576877 33240 109979093
Injection site discolouration 25.25 10.10 8 576958 9095 110003238
Cytopenia 25.21 10.10 77 576889 30039 109982294
Rebound effect 25.19 10.10 24 576942 14782 109997551
Appendicitis 25.12 10.10 71 576895 28393 109983940
Seasonal allergy 25.10 10.10 40 576926 19682 109992651
Immunosuppressant drug level increased 25.09 10.10 15 576951 11709 110000624
Swollen tongue 25.05 10.10 198 576768 60164 109952169
Respiratory tract congestion 25.05 10.10 80 576886 30777 109981556
Drug hypersensitivity 24.76 10.10 2719 574247 451371 109560962
Alcohol poisoning 24.74 10.10 103 576863 8917 110003416
Hypothyroidism 24.62 10.10 252 576714 72647 109939686
Non-small cell lung cancer 24.49 10.10 94 576872 7841 110004492
Neuropathy peripheral 24.43 10.10 730 576236 178547 109833786
Dementia 24.42 10.10 84 576882 31589 109980744
Throat tightness 24.36 10.10 91 576875 33398 109978935
Sarcoidosis 24.34 10.10 18 576948 12561 109999772
Allodynia 24.31 10.10 41 576925 2042 110010291
Faeces discoloured 24.21 10.10 93 576873 33855 109978478
Rhinitis allergic 24.11 10.10 35 576931 17887 109994446
Tremor 24.09 10.10 838 576128 201394 109810939
Respiratory syncytial virus infection 24.04 10.10 24 576942 14460 109997873
Cytomegalovirus colitis 23.96 10.10 4 576962 7057 110005276
Breast cancer female 23.92 10.10 18 576948 12450 109999883
Eye pain 23.85 10.10 158 576808 49941 109962392
Premature labour 23.82 10.10 9 576957 9163 110003170
Blood immunoglobulin E increased 23.76 10.10 5 576961 7477 110004856
Pruritus genital 23.74 10.10 3 576963 6519 110005814
Colitis 23.68 10.10 383 576583 101940 109910393
Cutaneous vasculitis 23.64 10.10 19 576947 12710 109999623
Transfusion 23.63 10.10 62 576904 25410 109986923
Aortic stenosis 23.62 10.10 20 576946 13039 109999294
Kidney transplant rejection 23.40 10.10 17 576949 11970 110000363
Neuritis 23.38 10.10 5 576961 7394 110004939
Gestational diabetes 23.34 10.10 5 576961 7384 110004949
Euglycaemic diabetic ketoacidosis 23.32 10.10 16 576950 11607 110000726
Paradoxical drug reaction 23.30 10.10 11 576955 9806 110002527
Foreign body embolism 23.27 10.10 7 576959 11 110012322
Eye swelling 23.27 10.10 91 576875 32957 109979376
Dermatitis allergic 23.25 10.10 49 576917 21675 109990658
Platelet count decreased 23.23 10.10 974 575992 229469 109782864
Nephropathy toxic 23.18 10.10 70 576896 27408 109984925
Squamous cell carcinoma 22.98 10.10 38 576928 18425 109993908
Concomitant disease aggravated 22.97 10.10 31 576935 16333 109996000
Myocarditis 22.97 10.10 80 576886 29975 109982358
Exostosis 22.94 10.10 352 576614 45604 109966729
Sedation complication 22.78 10.10 43 576923 19812 109992521
Acute chest syndrome 22.72 10.10 40 576926 2063 110010270
Accidental poisoning 22.71 10.10 44 576922 2443 110009890
Left ventricular dysfunction 22.71 10.10 56 576910 23437 109988896
Atrioventricular block 22.67 10.10 33 576933 16844 109995489
Diplopia 22.63 10.10 127 576839 41767 109970566
Hysterectomy 22.53 10.10 93 576873 8021 110004312
Eye irritation 22.37 10.10 94 576872 33358 109978975
Product complaint 22.34 10.10 137 576829 13835 109998498
Multiple drug therapy 22.30 10.10 7 576959 8007 110004326
Victim of homicide 22.25 10.10 15 576951 248 110012085
Eyelid ptosis 22.22 10.10 22 576944 13305 109999028
Emotional distress 22.19 10.10 343 576623 44504 109967829
Syringe issue 22.11 10.10 11 576955 9514 110002819
Pulmonary tuberculosis 22.06 10.10 10 576956 9129 110003204
Ejection fraction decreased 22.04 10.10 124 576842 40756 109971577
White blood cell count decreased 21.99 10.10 975 575991 228415 109783918
Oxygen saturation decreased 21.94 10.10 637 576329 156345 109855988
Procedural pain 21.93 10.10 103 576863 35462 109976871
Depressed mood 21.88 10.10 207 576759 60602 109951731
Periorbital oedema 21.86 10.10 13 576953 10179 110002154
Enterococcal infection 21.75 10.10 46 576920 20320 109992013
Human herpesvirus 6 infection 21.74 10.10 4 576962 6577 110005756
Red blood cell sedimentation rate abnormal 21.72 10.10 61 576905 24448 109987885
Aplasia 21.69 10.10 7 576959 7866 110004467
Blood calcium increased 21.66 10.10 38 576928 18002 109994331
Dyslipidaemia 21.66 10.10 31 576935 15934 109996399
Nephropathy 21.58 10.10 23 576943 13444 109998889
Blood lactate dehydrogenase increased 21.52 10.10 139 576827 44195 109968138
Rash 21.43 10.10 4717 572249 816247 109196086
Renal tubular necrosis 21.40 10.10 84 576882 30391 109981942
Vomiting 21.38 10.10 5207 571759 905468 109106865
Graft versus host disease 21.34 10.10 41 576925 18765 109993568
Vitamin B12 deficiency 21.32 10.10 13 576953 10042 110002291
Cervix neoplasm 21.26 10.10 13 576953 180 110012153
Anoxia 21.22 10.10 18 576948 426 110011907
Organising pneumonia 21.01 10.10 26 576940 14217 109998116
Dermatitis exfoliative 20.99 10.10 17 576949 11330 110001003
Cytokine release syndrome 20.97 10.10 250 576716 70056 109942277
Respiratory disorder 20.92 10.10 504 576462 70878 109941455
Dry eye 20.91 10.10 188 576778 55605 109956728
Drug eruption 20.91 10.10 179 576787 53480 109958853
Hyperlipidaemia 20.84 10.10 106 576860 35742 109976591
Feeling hot 20.76 10.10 342 576624 90764 109921569
Motor dysfunction 20.72 10.10 62 576904 24344 109987989
Blood urea increased 20.67 10.10 185 576781 54772 109957561
Nephrotic syndrome 20.66 10.10 25 576941 13806 109998527
Adverse drug reaction 20.60 10.10 708 576258 104851 109907482
General symptom 20.47 10.10 96 576870 8750 110003583
Thermophobia 20.46 10.10 9 576957 59 110012274
Diffuse large B-cell lymphoma recurrent 20.44 10.10 4 576962 6295 110006038
Sepsis 20.42 10.10 1451 575515 325895 109686438
Injection site extravasation 20.40 10.10 14 576952 10155 110002178
Steroid dependence 20.40 10.10 93 576873 8376 110003957
Device use error 20.35 10.10 11 576955 9078 110003255
Mite allergy 20.34 10.10 3 576963 5800 110006533
Skin burning sensation 20.34 10.10 53 576913 21772 109990561
Faecal calprotectin increased 20.32 10.10 5 576961 6714 110005619
Poor venous access 20.31 10.10 63 576903 24459 109987874
Drug screen negative 20.27 10.10 16 576950 341 110011992
Haemorrhage intracranial 20.25 10.10 80 576886 28889 109983444
Gastroenteritis 20.21 10.10 119 576847 38681 109973652
Visual impairment 20.19 10.10 540 576426 133888 109878445
Pulmonary mass 20.19 10.10 113 576853 37188 109975145
Skin toxicity 20.17 10.10 19 576947 11764 110000569
Normochromic normocytic anaemia 20.15 10.10 23 576943 13034 109999299
Ketoacidosis 20.09 10.10 14 576952 10073 110002260
Alcohol use 20.07 10.10 57 576909 4065 110008268
Exercise tolerance decreased 20.02 10.10 20 576946 12047 110000286
Affect lability 19.98 10.10 42 576924 18595 109993738
Gastrooesophageal reflux disease 19.97 10.10 1139 575827 178837 109833496
Post laminectomy syndrome 19.95 10.10 17 576949 405 110011928
Escherichia infection 19.86 10.10 61 576905 23755 109988578
Shock haemorrhagic 19.85 10.10 74 576892 27173 109985160
Sleep terror 19.83 10.10 5 576961 6605 110005728
Haematoma 19.80 10.10 202 576764 58274 109954059
Oropharyngeal discomfort 19.70 10.10 15 576951 10312 110002021
Benign prostatic hyperplasia 19.62 10.10 41 576925 18193 109994140
Gingival pain 19.58 10.10 145 576821 15591 109996742
Neurological symptom 19.54 10.10 32 576934 15576 109996757
Gastroenteritis viral 19.51 10.10 90 576876 31136 109981197
Pneumonia cytomegaloviral 19.48 10.10 6 576960 6948 110005385
Pulmonary hypertension 19.43 10.10 189 576777 55031 109957302
Coordination abnormal 19.38 10.10 67 576899 25161 109987172
Eyelid oedema 19.38 10.10 31 576935 15231 109997102
Autoimmune haemolytic anaemia 19.34 10.10 16 576950 10551 110001782
Product counterfeit 19.31 10.10 15 576951 312 110012021
Weight decreased 19.30 10.10 2142 574824 465915 109546418
Atrial tachycardia 19.28 10.10 12 576954 9166 110003167
Faeces soft 19.28 10.10 18 576948 11192 110001141
Leukoencephalopathy 19.27 10.10 97 576869 9098 110003235
Hypervolaemia 19.27 10.10 165 576801 49295 109963038
Eye inflammation 19.25 10.10 12 576954 9159 110003174
Blood iron decreased 19.20 10.10 45 576921 19169 109993164
Hepatic enzyme 19.20 10.10 65 576901 5098 110007235
Depressive symptom 19.11 10.10 10 576956 8404 110003929
Klebsiella infection 19.10 10.10 48 576918 19961 109992372
Escherichia bacteraemia 19.09 10.10 15 576951 10149 110002184
Optic neuritis 19.05 10.10 18 576948 11129 110001204
Abortion induced 19.01 10.10 9 576957 8010 110004323
Blood pressure abnormal 19.01 10.10 57 576909 22367 109989966
Nasal oedema 18.98 10.10 6 576960 6833 110005500
Pain in jaw 18.93 10.10 173 576793 51004 109961329
Sinusitis fungal 18.86 10.10 43 576923 2677 110009656
Lip oedema 18.85 10.10 8 576958 7592 110004741
Pericardial effusion 18.83 10.10 199 576767 57018 109955315
Epigastric discomfort 18.82 10.10 95 576871 8920 110003413
Rhabdomyolysis 18.79 10.10 481 576485 119920 109892413
Substance dependence 18.78 10.10 21 576945 704 110011629
Gastric ulcer 18.76 10.10 126 576840 39701 109972632
Varicella zoster virus infection 18.76 10.10 5 576961 6363 110005970
Skin plaque 18.74 10.10 23 576943 12622 109999711
Kounis syndrome 18.73 10.10 4 576962 5921 110006412
Ascites 18.72 10.10 356 576610 92452 109919881
Chills 18.69 10.10 808 576158 189772 109822561
Lupus vulgaris 18.67 10.10 264 576702 33619 109978714
Vasoplegia syndrome 18.64 10.10 3 576963 5436 110006897
Haemolytic anaemia 18.59 10.10 52 576914 20868 109991465
Head discomfort 18.59 10.10 45 576921 18955 109993378
Impaired reasoning 18.57 10.10 10 576956 107 110012226
Congenital central hypoventilation syndrome 18.52 10.10 7 576959 29 110012304
Skin reaction 18.47 10.10 53 576913 21091 109991242
Graft versus host disease in skin 18.46 10.10 10 576956 8244 110004089
Femur fracture 18.39 10.10 146 576820 44323 109968010
Nocardiosis 18.37 10.10 8 576958 7478 110004855
Pulmonary granuloma 18.33 10.10 41 576925 2520 110009813
Respiratory failure 18.31 10.10 927 576039 214405 109797928
Skin cancer 18.30 10.10 41 576925 17743 109994590
Lacrimation increased 18.29 10.10 91 576875 30859 109981474
Hepatitis B 18.29 10.10 14 576952 9598 110002735
Aggression 18.26 10.10 209 576757 59001 109953332
Platelet count increased 18.23 10.10 73 576893 26261 109986072
Gastrointestinal infection 18.21 10.10 28 576938 13977 109998356
Dystonia 18.20 10.10 71 576895 25734 109986599
Clostridium test positive 18.14 10.10 18 576948 10875 110001458
Salivary hypersecretion 18.06 10.10 40 576926 17381 109994952
Retinitis 17.86 10.10 252 576714 32075 109980258
Rectal haemorrhage 17.84 10.10 482 576484 119351 109892982
Body temperature decreased 17.83 10.10 116 576850 36819 109975514
Tardive dyskinesia 17.80 10.10 27 576939 13552 109998781
Sedation 17.78 10.10 483 576483 69200 109943133
Hypoaesthesia oral 17.66 10.10 39 576927 16963 109995370
Prescribed underdose 17.57 10.10 455 576511 64719 109947614
Hepatocellular injury 17.54 10.10 174 576792 50468 109961865
International normalised ratio increased 17.45 10.10 333 576633 86439 109925894
Acute graft versus host disease in intestine 17.44 10.10 4 576962 5635 110006698
Ear pruritus 17.44 10.10 8 576958 7252 110005081
Rash macular 17.43 10.10 124 576842 38562 109973771
Failure to thrive 17.42 10.10 126 576840 13448 109998885
Gas poisoning 17.41 10.10 9 576957 88 110012245
Polyuria 17.37 10.10 42 576924 17696 109994637
Anti factor V antibody 17.36 10.10 14 576952 308 110012025
Hypocholesterolaemia 17.36 10.10 73 576893 6348 110005985
Sensitivity to weather change 17.36 10.10 16 576950 10012 110002321
Choroidal infarction 17.36 10.10 12 576954 207 110012126
Therapy non-responder 17.35 10.10 995 575971 156312 109856021
Herpes simplex 17.34 10.10 35 576931 15729 109996604
Acute coronary syndrome 17.34 10.10 62 576904 23050 109989283
Vitamin D deficiency 17.33 10.10 45 576921 18507 109993826
Rash pustular 17.31 10.10 25 576941 12804 109999529
Hyperglycaemia 17.28 10.10 326 576640 84764 109927569
Hip arthroplasty 17.26 10.10 397 576569 55416 109956917
Ulcer haemorrhage 17.25 10.10 187 576779 22384 109989949
Environmental exposure 17.20 10.10 15 576951 369 110011964
Oesophageal carcinoma 17.04 10.10 21 576945 11503 110000830
Renal injury 17.02 10.10 46 576920 18667 109993666
Diarrhoea haemorrhagic 16.97 10.10 35 576931 15604 109996729
Ataxia 16.96 10.10 90 576876 30018 109982315
Bronchiectasis 16.92 10.10 116 576850 36377 109975956
Tumour haemorrhage 16.90 10.10 63 576903 5182 110007151
Protein urine present 16.90 10.10 21 576945 11463 110000870
Wheelchair user 16.83 10.10 10 576956 7832 110004501
Mania 16.82 10.10 54 576912 20742 109991591
Ventricular extrasystoles 16.81 10.10 61 576905 22580 109989753
Atrioventricular block second degree 16.77 10.10 11 576955 8170 110004163
Musculoskeletal stiffness 16.72 10.10 1686 575280 278136 109734197
Increased appetite 16.70 10.10 33 576933 14944 109997389
Blindness 16.65 10.10 116 576850 36243 109976090
Fungal infection 16.60 10.10 177 576789 50629 109961704
Posterior reversible encephalopathy syndrome 16.52 10.10 106 576860 33755 109978578
Stenotrophomonas infection 16.51 10.10 5 576961 5853 110006480
Staphylococcal infection 16.45 10.10 261 576705 69683 109942650
Breast cancer stage I 16.45 10.10 9 576957 7378 110004955
Tumour pain 16.41 10.10 43 576923 2924 110009409
Postoperative delirium 16.39 10.10 22 576944 893 110011440
Arteriospasm coronary 16.38 10.10 14 576952 9086 110003247
Orthopnoea 16.38 10.10 20 576946 11001 110001332
Dermatitis 16.36 10.10 82 576884 27755 109984578
Catatonia 16.28 10.10 21 576945 11279 110001054
Electrocardiogram abnormal 16.26 10.10 47 576919 18662 109993671
Duodenal ulcer 16.26 10.10 50 576916 19464 109992869
Treatment failure 16.22 10.10 1668 575298 275566 109736767
Hyperuricaemia 16.21 10.10 32 576934 14499 109997834
Toxic skin eruption 16.20 10.10 81 576885 27434 109984899
Troponin increased 16.20 10.10 90 576876 29676 109982657
Small intestinal obstruction 16.18 10.10 247 576719 31966 109980367
Arthrofibrosis 16.12 10.10 9 576957 104 110012229
Conjunctivitis allergic 16.09 10.10 8 576958 6923 110005410
Anti-cyclic citrullinated peptide antibody 16.00 10.10 167 576799 19797 109992536
Arterial occlusive disease 15.99 10.10 35 576931 15273 109997060
Visceral oedema 15.95 10.10 8 576958 73 110012260
Product administration error 15.95 10.10 121 576845 37096 109975237
N-terminal prohormone brain natriuretic peptide increased 15.90 10.10 6 576960 6115 110006218
Skin disorder 15.90 10.10 145 576821 42768 109969565
Product preparation error 15.90 10.10 20 576946 10859 110001474
Graft versus host disease in gastrointestinal tract 15.90 10.10 14 576952 8954 110003379
JC virus infection 15.87 10.10 4 576962 5286 110007047
Cardiomyopathy 15.82 10.10 106 576860 33419 109978914
Haemodialysis 15.78 10.10 44 576922 17675 109994658
Clostridium difficile colitis 15.76 10.10 149 576817 43629 109968704
Pyelonephritis acute 15.76 10.10 9 576957 7204 110005129
Gangrene 15.76 10.10 39 576927 16302 109996031
Tongue oedema 15.74 10.10 12 576954 8244 110004089
Labelled drug-drug interaction medication error 15.73 10.10 89 576877 29213 109983120
Vitamin B12 decreased 15.73 10.10 4 576962 5253 110007080
Smear cervix abnormal 15.72 10.10 40 576926 2672 110009661
Postmortem blood drug level abnormal 15.66 10.10 18 576948 622 110011711
Acute on chronic liver failure 15.57 10.10 15 576951 421 110011912
Blood triglycerides increased 15.53 10.10 68 576898 23858 109988475
Haemorrhagic diathesis 15.52 10.10 10 576956 7498 110004835
Renal disorder 15.51 10.10 174 576792 49305 109963028
Activated partial thromboplastin time prolonged 15.49 10.10 62 576904 22306 109990027
Hyperbilirubinaemia 15.49 10.10 95 576871 30576 109981757
Apnoea 15.48 10.10 123 576843 13516 109998817
Brain abscess 15.46 10.10 8 576958 6766 110005567
Oliguria 15.40 10.10 48 576918 18609 109993724
Spinal operation 15.34 10.10 104 576862 10868 110001465
Acute pulmonary oedema 15.29 10.10 42 576924 16954 109995379
Hepatic function abnormal 15.22 10.10 352 576614 88943 109923390
Demyelination 15.22 10.10 16 576950 9413 110002920
Metastases to lymph nodes 15.19 10.10 35 576931 14997 109997336
Upper-airway cough syndrome 15.17 10.10 38 576928 15819 109996514
Limb discomfort 15.16 10.10 138 576828 40716 109971617
Decreased gait velocity 15.14 10.10 11 576955 206 110012127
Haematemesis 15.13 10.10 217 576749 58891 109953442
Formication 15.11 10.10 64 576902 5584 110006749
Blood urine present 15.08 10.10 70 576896 24175 109988158
Lichenoid keratosis 15.05 10.10 7 576959 6295 110006038
Cerebellar syndrome 15.05 10.10 7 576959 6295 110006038
Systemic candida 14.93 10.10 18 576948 9956 110002377
Yawning 14.90 10.10 28 576938 1519 110010814
Lung cancer metastatic 14.87 10.10 52 576914 4146 110008187
Tendon rupture 14.86 10.10 32 576934 14046 109998287
Vitreous haemorrhage 14.85 10.10 3 576963 4617 110007716
Metastatic renal cell carcinoma 14.82 10.10 37 576929 2443 110009890
Hypoacusis 14.80 10.10 115 576851 35076 109977257
Hepatic necrosis 14.75 10.10 18 576948 9904 110002429
Hypothalamic pituitary adrenal axis suppression 14.74 10.10 18 576948 664 110011669
Foreign body aspiration 14.73 10.10 16 576950 519 110011814
Cardiac dysfunction 14.73 10.10 7 576959 6216 110006117
Hypoventilation 14.71 10.10 82 576884 7999 110004334
Hypovolaemic shock 14.70 10.10 34 576932 14549 109997784
Erysipelas 14.66 10.10 29 576937 13129 109999204
Hyperprolactinaemia 14.66 10.10 8 576958 6567 110005766
Renal function test abnormal 14.65 10.10 15 576951 8931 110003402
Pulmonary thrombosis 14.64 10.10 123 576843 13740 109998593
Diabetes insipidus 14.64 10.10 8 576958 6562 110005771
Infusion site swelling 14.60 10.10 18 576948 9859 110002474
Multiple allergies 14.57 10.10 26 576940 12237 110000096
Iridocyclitis 14.56 10.10 5 576961 5403 110006930
Personality disorder 14.56 10.10 28 576938 12809 109999524
Immune thrombocytopenia 14.55 10.10 64 576902 22430 109989903
Infusion site erythema 14.53 10.10 25 576941 11934 110000399
Vestibular ischaemia 14.45 10.10 5 576961 15 110012318
Ovarian cyst 14.43 10.10 32 576934 13898 109998435
Carbon dioxide abnormal 14.42 10.10 17 576949 604 110011729
Endoscopic retrograde cholangiopancreatography 14.40 10.10 11 576955 223 110012110
Cystitis haemorrhagic 14.40 10.10 26 576940 12183 110000150
Lymphocyte count decreased 14.35 10.10 211 576755 57032 109955301
Tonsillitis 14.34 10.10 13 576953 8200 110004133
Cardiac tamponade 14.33 10.10 23 576943 11284 110001049
Erythema multiforme 14.28 10.10 59 576907 21038 109991295
Piloerection 14.22 10.10 20 576946 849 110011484
Polymyalgia rheumatica 14.13 10.10 8 576958 6434 110005899
Hypotonia 14.09 10.10 39 576927 15706 109996627
Blood pressure diastolic abnormal 14.08 10.10 78 576888 25737 109986596
Intestinal pseudo-obstruction 14.06 10.10 44 576922 3312 110009021
Pollakiuria 14.02 10.10 155 576811 44040 109968293
Coronary artery bypass 13.99 10.10 7 576959 6035 110006298
Bone cyst 13.96 10.10 46 576920 3557 110008776
Self-medication 13.96 10.10 67 576899 6165 110006168
Parosmia 13.95 10.10 117 576849 13063 109999270
Product formulation issue 13.93 10.10 25 576941 1309 110011024
Second primary malignancy 13.87 10.10 48 576918 18020 109994313
Flatulence 13.86 10.10 190 576776 51959 109960374
Hepatic fibrosis 13.81 10.10 13 576953 8053 110004280
Cholestasis 13.79 10.10 245 576721 64273 109948060
Venoocclusive disease 13.76 10.10 8 576958 6342 110005991
Unintended pregnancy 13.74 10.10 4 576962 4804 110007529
Eye infection 13.73 10.10 35 576931 14483 109997850
Cytomegalovirus test positive 13.71 10.10 10 576956 7026 110005307
Product administered to patient of inappropriate age 13.70 10.10 13 576953 8023 110004310
Infective pulmonary exacerbation of cystic fibrosis 13.67 10.10 36 576930 14735 109997598
Antipsychotic drug level increased 13.63 10.10 10 576956 7005 110005328
Porphyria acute 13.62 10.10 154 576812 18626 109993707
Pulmonary pain 13.54 10.10 8 576958 6285 110006048
Pneumonitis 13.52 10.10 300 576666 76231 109936102
Hepatitis toxic 13.50 10.10 7 576959 5914 110006419
Sphincter of Oddi dysfunction 13.49 10.10 16 576950 572 110011761
Movement disorder 13.49 10.10 123 576843 36281 109976052
Middle insomnia 13.47 10.10 58 576908 20444 109991889
Amenorrhoea 13.46 10.10 17 576949 9214 110003119
Renal cell carcinoma 13.44 10.10 76 576890 7454 110004879
Blood pressure inadequately controlled 13.43 10.10 12 576954 7621 110004712
Papule 13.43 10.10 20 576946 10113 110002220
Acute myeloid leukaemia recurrent 13.42 10.10 5 576961 5134 110007199
Pyelonephritis 13.39 10.10 77 576889 25173 109987160
Overlap syndrome 13.35 10.10 87 576879 8972 110003361
Nystagmus 13.35 10.10 25 576941 11552 110000781
Mycobacterium avium complex infection 13.32 10.10 7 576959 5870 110006463
Right ventricular failure 13.31 10.10 80 576886 25874 109986459
Gallbladder injury 13.27 10.10 24 576942 1264 110011069
Supraventricular tachycardia 13.21 10.10 74 576892 24348 109987985
Skin papilloma 13.18 10.10 10 576956 6886 110005447
Sinus arrest 13.14 10.10 3 576963 4239 110008094
Pupil fixed 13.13 10.10 47 576919 3791 110008542
Blood pressure systolic abnormal 13.06 10.10 76 576890 24774 109987559
Peritonitis 13.05 10.10 108 576858 32499 109979834
Bundle branch block left 13.03 10.10 30 576936 12858 109999475
Exposure via breast milk 13.03 10.10 21 576945 1007 110011326
Sputum increased 13.01 10.10 62 576904 5689 110006644
Sleep disorder due to general medical condition, hypersomnia type 13.00 10.10 31 576935 1988 110010345
Premature rupture of membranes 12.99 10.10 4 576962 4633 110007700
Cryptococcosis 12.97 10.10 4 576962 4627 110007706
Foetal exposure during pregnancy 12.96 10.10 12 576954 7493 110004840
Psychiatric decompensation 12.87 10.10 7 576959 5758 110006575
Abdominal pain 12.85 10.10 2419 574547 510570 109501763
Subacute cutaneous lupus erythematosus 12.80 10.10 5 576961 4989 110007344
Hormone replacement therapy 12.78 10.10 3 576963 0 110012333
Skin irritation 12.77 10.10 43 576923 16276 109996057
Bradykinesia 12.70 10.10 23 576943 10765 110001568
Infusion site extravasation 12.66 10.10 26 576940 11608 110000725
Hypercalcaemia 12.65 10.10 326 576640 46331 109966002
Papilloedema 12.62 10.10 12 576954 7397 110004936
Renal cancer metastatic 12.59 10.10 18 576948 776 110011557
Device occlusion 12.59 10.10 39 576927 15146 109997187
Type I hypersensitivity 12.57 10.10 9 576957 6384 110005949
Bradyarrhythmia 12.55 10.10 5 576961 4929 110007404
Oedema 12.51 10.10 1265 575701 208711 109803622
Secondary amyloidosis 12.51 10.10 12 576954 335 110011998
Polydipsia 12.46 10.10 13 576953 7675 110004658
Aptyalism 12.45 10.10 19 576947 869 110011464
Neutrophil count decreased 12.43 10.10 510 576456 120431 109891902
Hypokinesia 12.43 10.10 65 576901 21761 109990572
Lung transplant 12.43 10.10 6 576960 5280 110007053
Therapeutic reaction time decreased 12.40 10.10 6 576960 5273 110007060
Decreased activity 12.39 10.10 24 576942 10950 110001383
Lower gastrointestinal haemorrhage 12.33 10.10 52 576914 18434 109993899
Gynaecomastia 12.32 10.10 19 576947 9471 110002862
Erythema nodosum 12.27 10.10 10 576956 6643 110005690
Polyarthritis 12.24 10.10 54 576912 18909 109993424
Normal newborn 12.22 10.10 171 576795 21725 109990608
Pharyngeal swelling 12.17 10.10 28 576938 12004 110000329
Spleen congestion 12.16 10.10 14 576952 485 110011848
Maternal exposure before pregnancy 12.10 10.10 12 576954 7253 110005080
Bradyphrenia 12.10 10.10 27 576939 11701 110000632
Lymphoma 12.10 10.10 59 576907 20112 109992221
Tooth loss 12.08 10.10 78 576888 8018 110004315
Systolic dysfunction 12.03 10.10 4 576962 4411 110007922
Hepatic lesion 12.01 10.10 16 576950 8477 110003856
Chest X-ray abnormal 11.99 10.10 16 576950 8471 110003862
Haemorrhage subcutaneous 11.97 10.10 7 576959 5532 110006801
Petit mal epilepsy 11.97 10.10 13 576953 7534 110004799
Hepatitis cholestatic 11.97 10.10 49 576917 17517 109994816
Tendonitis 11.97 10.10 197 576769 25886 109986447
Wrong technique in device usage process 11.96 10.10 11 576955 6890 110005443
Tachyphylaxis 11.96 10.10 13 576953 422 110011911
Hypoglycaemic coma 11.95 10.10 7 576959 5526 110006807
Left ventricular failure 11.93 10.10 26 576940 11363 110000970
Back pain 11.93 10.10 2154 574812 368842 109643491
Radiculopathy 11.92 10.10 56 576910 19280 109993053
Mandibular mass 11.92 10.10 10 576956 233 110012100
Gastric polyps 11.91 10.10 7 576959 5516 110006817
Lymphocyte count increased 11.88 10.10 12 576954 7191 110005142
Faecalith 11.87 10.10 5 576961 29 110012304
Sinus node dysfunction 11.85 10.10 18 576948 9029 110003304
Impaired driving ability 11.84 10.10 65 576901 6305 110006028
Catheterisation cardiac 11.80 10.10 9 576957 6182 110006151
Tension headache 11.78 10.10 20 576946 9598 110002735
Disorganised speech 11.77 10.10 41 576925 3262 110009071
Large intestine polyp 11.71 10.10 40 576926 15077 109997256
Blood parathyroid hormone decreased 11.70 10.10 112 576854 12977 109999356
Pulmonary function test decreased 11.70 10.10 17 576949 8683 110003650
Candida infection 11.68 10.10 178 576788 47831 109964502
Gingival hypertrophy 11.67 10.10 4 576962 4327 110008006
Ear infection 11.64 10.10 244 576722 62488 109949845
Bone density abnormal 11.62 10.10 3 576963 3900 110008433
Heavy menstrual bleeding 11.56 10.10 45 576921 16320 109996013
Coronavirus infection 11.55 10.10 20 576946 9525 110002808
Pulmonary embolism 11.50 10.10 1283 575683 213191 109799142
Tendon disorder 11.50 10.10 16 576950 8321 110004012
Hallucination, synaesthetic 11.49 10.10 6 576960 60 110012273
Neurosis 11.44 10.10 15 576951 595 110011738
Red cell distribution width increased 11.44 10.10 50 576916 17552 109994781
Retinal haemorrhage 11.42 10.10 20 576946 9481 110002852
Nervous system disorder 11.40 10.10 108 576858 31613 109980720
Tachypnoea 11.40 10.10 141 576825 39254 109973079
Appetite disorder 11.35 10.10 21 576945 9748 110002585
Blood prolactin increased 11.33 10.10 5 576961 4637 110007696
Gastrointestinal inflammation 11.32 10.10 20 576946 9449 110002884
Dyspepsia 11.31 10.10 1150 575816 189815 109822518
Insurance issue 11.30 10.10 24 576942 10588 110001745
Pseudomembranous colitis 11.30 10.10 10 576956 6381 110005952
Colitis ulcerative 11.30 10.10 312 576654 77051 109935282
Maternal exposure during breast feeding 11.27 10.10 4 576962 4234 110008099
Device defective 11.26 10.10 3 576963 3819 110008514
Facial paralysis 11.21 10.10 77 576889 24137 109988196
Vitreous floaters 11.18 10.10 19 576947 9115 110003218
Malignant catatonia 11.18 10.10 16 576950 690 110011643
Learning disability 11.16 10.10 9 576957 198 110012135
Thyroid disorder 11.15 10.10 48 576918 16921 109995412
White blood cell count increased 11.13 10.10 403 576563 96439 109915894
Clostridium difficile infection 11.12 10.10 198 576768 51931 109960402
Device use issue 11.09 10.10 3 576963 3781 110008552
Sudden death 11.08 10.10 78 576888 24317 109988016
Pupillary light reflex tests abnormal 11.05 10.10 12 576954 389 110011944
Carpal tunnel syndrome 10.92 10.10 71 576895 22539 109989794
Defaecation urgency 10.89 10.10 18 576948 8729 110003604
Focal segmental glomerulosclerosis 10.88 10.10 4 576962 4141 110008192
Paranoid personality disorder 10.86 10.10 5 576961 37 110012296
Angiopathy 10.84 10.10 18 576948 8712 110003621
Metabolic alkalosis 10.84 10.10 8 576958 5587 110006746
Granuloma skin 10.82 10.10 98 576868 11185 110001148
Product residue present 10.81 10.10 45 576921 3896 110008437
Exposure via inhalation 10.74 10.10 7 576959 109 110012224
Central pain syndrome 10.73 10.10 17 576949 803 110011530
Gait disturbance 10.70 10.10 1279 575687 276929 109735404
Faecaloma 10.70 10.10 122 576844 14786 109997547
Central nervous system injury 10.70 10.10 8 576958 157 110012176
Premature baby 10.69 10.10 6 576960 4849 110007484
Glucose tolerance impaired 10.69 10.10 22 576944 9815 110002518
Mean cell haemoglobin decreased 10.68 10.10 13 576953 7161 110005172
Eye haemorrhage 10.66 10.10 29 576937 11745 110000588
Substance use 10.63 10.10 33 576933 2473 110009860
Hyperpyrexia 10.62 10.10 16 576950 8053 110004280
International normalised ratio fluctuation 10.60 10.10 4 576962 4076 110008257
Metabolic encephalopathy 10.57 10.10 96 576870 10964 110001369
Mastocytosis 10.55 10.10 17 576949 815 110011518
Henoch-Schonlein purpura 10.53 10.10 3 576963 3654 110008679
Gastritis 10.52 10.10 207 576759 53492 109958841
Diverticulum intestinal 10.51 10.10 29 576937 11690 110000643
Squamous cell carcinoma of skin 10.50 10.10 50 576916 17153 109995180
Neutropenic sepsis 10.50 10.10 106 576860 30640 109981693
Periorbital swelling 10.50 10.10 8 576958 5497 110006836
Long QT syndrome 10.49 10.10 13 576953 7105 110005228
Central nervous system stimulation 10.48 10.10 6 576960 73 110012260
Nephrolithiasis 10.46 10.10 264 576702 65948 109946385
Jaundice cholestatic 10.43 10.10 40 576926 14568 109997765
Colon gangrene 10.42 10.10 5 576961 41 110012292
Disease progression 10.42 10.10 1114 575852 242920 109769413
Bladder disorder 10.41 10.10 27 576939 11110 110001223
Pulmonary fibrosis 10.41 10.10 641 576325 101401 109910932
Mycobacterial infection 10.41 10.10 5 576961 4412 110007921
Embedded device 10.40 10.10 4 576962 4029 110008304
Haemorrhagic stroke 10.34 10.10 37 576929 13752 109998581
Atrial flutter 10.34 10.10 79 576887 24183 109988150
Antidepressant drug level above therapeutic 10.33 10.10 16 576950 741 110011592
Serum serotonin decreased 10.32 10.10 4 576962 18 110012315
Snake bite 10.32 10.10 4 576962 18 110012315
Polyp 10.28 10.10 23 576943 9957 110002376
Peritonitis bacterial 10.26 10.10 25 576941 10508 110001825
Cholelithiasis 10.26 10.10 252 576714 63170 109949163
Medical observation 10.23 10.10 9 576957 224 110012109
Micturition urgency 10.20 10.10 59 576907 19261 109993072
Metabolic disorder 10.20 10.10 25 576941 10485 110001848
Lymphocytosis 10.14 10.10 8 576958 5403 110006930
Maternal exposure during delivery 10.13 10.10 3 576963 3562 110008771
Atrioventricular block first degree 10.12 10.10 39 576927 14186 109998147
Blood pressure systolic decreased 10.12 10.10 36 576930 13405 109998928
Disturbance in social behaviour 10.10 10.10 7 576959 5051 110007282

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02AA05 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA55 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA56 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AJ17 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ18 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ19 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018689 Sensory System Agents
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist
CHEBI has role CHEBI:35482 opioid analgesic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:55322 ฮผ-opioid receptor agonist
CHEBI has role CHEBI:35480 analgesic

Related Drugs by ATC class:

N02AA Natural opium alkaloids 8 drugs
codeinedihydrocodeinehydromorphonemorphinenaloxonenaltrexonenicomorphineoxymorphone
N02AJ Opioids in combination with non-opioid analgesics 9 drugs
acetylsalicylic acidcelecoxibcodeinedexketoprofendihydrocodeinehydrocodoneibuprofenparacetamoltramadol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Severe pain indication 76948002
Acute postoperative pain indication 107401000119105
Chronic Pain with Opioid Tolerance indication
Neuropathic pain off-label use 247398009
Hypophosphatemia contraindication 4996001
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Asthenia contraindication 13791008
Constipation contraindication 14760008 DOID:2089
Mood swings contraindication 18963009
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Gastrointestinal perforation contraindication 51875005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Hemorrhoids contraindication 70153002 DOID:9746
Poisoning by acetaminophen contraindication 70273001
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Cor pulmonale contraindication 83291003 DOID:8515
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Drug-induced psychosis contraindication 191483003 DOID:1742
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Morbid obesity contraindication 238136002 DOID:11981
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Skin irritation contraindication 367466007
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Cardiovascular event risk contraindication 395112001
Breastfeeding (mother) contraindication 413712001
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001
Acute erosive gastritis contraindication 444926003
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.97 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 7976870 June 1, 2027 METHOD OF TREATING PATIENTS WITH GASTRIC RETENTIVE DOSAGE FORM
10MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 11304909 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
10MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 8808741 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
10MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492391 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
10MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492393 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
15MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 11304909 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
15MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 8808741 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
15MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492391 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
15MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492393 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
20MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 11304909 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
20MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 8808741 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
20MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492391 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
20MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492393 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
30MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 11304909 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
30MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 8808741 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
30MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492391 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
30MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492393 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
40MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 11304909 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
40MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 8808741 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
40MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492391 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
40MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492393 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
60MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 11304909 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
60MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 8808741 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
60MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492391 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
60MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492393 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
80MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 11304909 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
80MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 8808741 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
80MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492391 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
80MG OXYCONTIN KNOA PHARMA N022272 April 5, 2010 RX TABLET, EXTENDED RELEASE ORAL 9492393 Aug. 24, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 8372432 March 11, 2029 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 8668929 March 11, 2029 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 8377453 Nov. 19, 2029 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
13.5MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10004729 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
13.5MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10668060 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
13.5MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9682075 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
18MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10004729 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
18MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10668060 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
18MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9682075 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
27MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10004729 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
27MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10668060 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
27MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9682075 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
36MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10004729 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
36MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10668060 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
36MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9682075 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
9MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10004729 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
9MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10668060 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
9MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9682075 Dec. 10, 2030 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 8741885 May 16, 2032 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** XARTEMIS XR MALLINCKRODT INC N204031 March 11, 2014 DISCN TABLET, EXTENDED RELEASE ORAL 9468636 May 16, 2032 MANAGEMENT OF ACUTE PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
13.5MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10188644 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
13.5MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10646485 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
13.5MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9737530 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
13.5MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9968598 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
18MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10188644 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
18MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10646485 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
18MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9737530 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
18MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9968598 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
27MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10188644 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
27MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10646485 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
27MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9737530 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
27MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9968598 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
36MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10188644 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
36MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10646485 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
36MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9737530 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
36MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9968598 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
9MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10188644 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
9MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 10646485 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
9MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9737530 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
9MG XTAMPZA ER COLLEGIUM PHARM INC N208090 April 26, 2016 RX CAPSULE, EXTENDED RELEASE ORAL 9968598 Sept. 2, 2036 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST Ki 7.80 WOMBAT-PK CHEMBL
Kappa-type opioid receptor GPCR EC50 4.80 CHEMBL
Delta-type opioid receptor GPCR EC50 5.40 CHEMBL
Mu-type opioid receptor GPCR Ki 7.36 CHEMBL
Mu-type opioid receptor GPCR EC50 6.80 CHEMBL
Delta-type opioid receptor GPCR Ki 5.96 CHEMBL
Kappa-type opioid receptor GPCR Ki 6.49 CHEMBL
Acetylcholinesterase Enzyme IC50 4.12 CHEMBL
Kappa-type opioid receptor GPCR Ki 5.58 CHEMBL
Kappa-type opioid receptor GPCR EC50 4.80 CHEMBL

External reference:

IDSource
D00847 KEGG_DRUG
124-90-3 SECONDARY_CAS_RN
124133-68-2 SECONDARY_CAS_RN
4017996 VANDF
4017997 VANDF
4019870 VANDF
C0030049 UMLSCUI
CHEBI:7852 CHEBI
OOX PDB_CHEM_ID
CHEMBL656 ChEMBL_ID
CHEMBL1200890 ChEMBL_ID
DB00497 DRUGBANK_ID
CHEMBL3989826 ChEMBL_ID
D010098 MESH_DESCRIPTOR_UI
5284603 PUBCHEM_CID
7093 IUPHAR_LIGAND_ID
C016026 MESH_SUPPLEMENTAL_RECORD_UI
1701 INN_ID
CD35PMG570 UNII
159821 RXNORM
10664 MMSL
31648 MMSL
5216 MMSL
5217 MMSL
6369 MMSL
d00329 MMSL
001558 NDDF
001559 NDDF
004513 NDDF
116352007 SNOMEDCT_US
387024006 SNOMEDCT_US
414984009 SNOMEDCT_US
55452001 SNOMEDCT_US
CD35PMG570 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
oxycodone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0390 SOLUTION 5 mg ORAL ANDA 32 sections
oxycodone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0390 SOLUTION 5 mg ORAL ANDA 32 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1556 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1557 TABLET, FILM COATED, EXTENDED RELEASE 15 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1558 TABLET, FILM COATED, EXTENDED RELEASE 20 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1559 TABLET, FILM COATED, EXTENDED RELEASE 30 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1560 TABLET, FILM COATED, EXTENDED RELEASE 40 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1561 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1562 TABLET, FILM COATED, EXTENDED RELEASE 80 mg ORAL NDA AUTHORIZED GENERIC 33 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0827 SOLUTION 5 mg ORAL ANDA 35 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-4827 SOLUTION 5 mg ORAL ANDA 35 sections
OXYCODONE AND ACETAMINOPHEN HUMAN PRESCRIPTION DRUG LABEL 2 0406-0512 TABLET 5 mg ORAL ANDA 15 sections
OXYCODONE AND ACETAMINOPHEN HUMAN PRESCRIPTION DRUG LABEL 2 0406-0522 TABLET 7.50 mg ORAL ANDA 15 sections
OXYCODONE AND ACETAMINOPHEN HUMAN PRESCRIPTION DRUG LABEL 2 0406-0523 TABLET 10 mg ORAL ANDA 15 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-0552 TABLET 5 mg ORAL ANDA 36 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-0552 TABLET 5 mg ORAL ANDA 36 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8510 TABLET 10 mg ORAL ANDA 36 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8510 TABLET 10 mg ORAL ANDA 36 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8515 TABLET 15 mg ORAL ANDA 36 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8515 TABLET 15 mg ORAL ANDA 36 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8520 TABLET 20 mg ORAL ANDA 36 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8520 TABLET 20 mg ORAL ANDA 36 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8530 TABLET 30 mg ORAL ANDA 36 sections
OXYCODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8530 TABLET 30 mg ORAL ANDA 36 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-8556 SOLUTION 5 mg ORAL ANDA 35 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-8557 SOLUTION 100 mg ORAL ANDA 35 sections
Oxycodone Hydrochloride Human Prescription Drug Label 1 0904-6678 SOLUTION 5 mg ORAL ANDA 28 sections
Oxycodone Hydrochloride Human Prescription Drug Label 1 0904-6828 SOLUTION 5 mg ORAL ANDA 31 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6966 TABLET 5 mg ORAL ANDA 29 sections
Oxycodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6966 TABLET 5 mg ORAL ANDA 29 sections