lisinopril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin-converting enzyme inhibitors | 1587 | 76547-98-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 97 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 94 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.41 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 25 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.89 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 42 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 29, 1987 | FDA | MERCK |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Angioedema | 1558.30 | 9.74 | 1339 | 207343 | 38003 | 46439377 |
| Cardiac failure congestive | 550.42 | 9.74 | 1246 | 207436 | 90504 | 46386876 |
| Intestinal angioedema | 487.54 | 9.74 | 157 | 208525 | 432 | 46476948 |
| Myocardial infarction | 471.89 | 9.74 | 1219 | 207463 | 96309 | 46381071 |
| Swollen tongue | 314.16 | 9.74 | 509 | 208173 | 28723 | 46448657 |
| Cerebrovascular accident | 284.13 | 9.74 | 1045 | 207637 | 99994 | 46377386 |
| Rheumatoid arthritis | 234.20 | 9.74 | 449 | 208233 | 239766 | 46237614 |
| Off label use | 229.42 | 9.74 | 898 | 207784 | 378943 | 46098437 |
| Coronary artery disease | 223.20 | 9.74 | 477 | 208205 | 33275 | 46444105 |
| Exposure during pregnancy | 220.19 | 9.74 | 104 | 208578 | 108108 | 46369272 |
| Maternal exposure during pregnancy | 215.77 | 9.74 | 94 | 208588 | 102455 | 46374925 |
| Acute kidney injury | 215.29 | 9.74 | 1794 | 206888 | 234061 | 46243319 |
| Drug ineffective | 196.69 | 9.74 | 2012 | 206670 | 675826 | 45801554 |
| Pyrexia | 176.33 | 9.74 | 881 | 207801 | 347921 | 46129459 |
| Lip swelling | 173.81 | 9.74 | 364 | 208318 | 25031 | 46452349 |
| Contraindicated product administered | 160.83 | 9.74 | 78 | 208604 | 79869 | 46397511 |
| Infusion related reaction | 149.60 | 9.74 | 139 | 208543 | 101069 | 46376311 |
| Drug abuse | 141.69 | 9.74 | 53 | 208629 | 63355 | 46414025 |
| Drug intolerance | 141.28 | 9.74 | 277 | 208405 | 146772 | 46330608 |
| Synovitis | 134.89 | 9.74 | 52 | 208630 | 61023 | 46416357 |
| Acute myocardial infarction | 133.07 | 9.74 | 378 | 208304 | 31546 | 46445834 |
| Blood glucose increased | 131.06 | 9.74 | 653 | 208029 | 71360 | 46406020 |
| Hypertension | 128.32 | 9.74 | 1392 | 207290 | 194964 | 46282416 |
| C-reactive protein increased | 121.16 | 9.74 | 55 | 208627 | 58535 | 46418845 |
| Pemphigus | 121.06 | 9.74 | 27 | 208655 | 45247 | 46432133 |
| Systemic lupus erythematosus | 110.67 | 9.74 | 78 | 208604 | 65102 | 46412278 |
| Treatment failure | 110.19 | 9.74 | 153 | 208529 | 92934 | 46384446 |
| Febrile neutropenia | 108.57 | 9.74 | 159 | 208523 | 94468 | 46382912 |
| Drug hypersensitivity | 104.04 | 9.74 | 1598 | 207084 | 242227 | 46235153 |
| Hyperkalaemia | 103.98 | 9.74 | 476 | 208206 | 50233 | 46427147 |
| Abortion spontaneous | 101.75 | 9.74 | 34 | 208648 | 43612 | 46433768 |
| Interstitial lung disease | 99.16 | 9.74 | 59 | 208623 | 53890 | 46423490 |
| Completed suicide | 97.82 | 9.74 | 1040 | 207642 | 144880 | 46332500 |
| Neutropenia | 94.38 | 9.74 | 326 | 208356 | 142878 | 46334502 |
| Renal failure | 82.95 | 9.74 | 824 | 207858 | 112770 | 46364610 |
| Lactic acidosis | 80.75 | 9.74 | 333 | 208349 | 33576 | 46443804 |
| Hepatic function abnormal | 79.91 | 9.74 | 27 | 208655 | 34394 | 46442986 |
| Dehydration | 78.82 | 9.74 | 1073 | 207609 | 158467 | 46318913 |
| Hand deformity | 77.06 | 9.74 | 29 | 208653 | 34545 | 46442835 |
| Lower respiratory tract infection | 75.25 | 9.74 | 81 | 208601 | 55008 | 46422372 |
| Pancreatitis | 74.72 | 9.74 | 389 | 208293 | 43238 | 46434142 |
| General physical health deterioration | 74.61 | 9.74 | 266 | 208416 | 115503 | 46361877 |
| Product dose omission issue | 67.80 | 9.74 | 1094 | 207588 | 167426 | 46309954 |
| Coronary arterial stent insertion | 67.13 | 9.74 | 73 | 208609 | 2780 | 46474600 |
| Hypotensive transfusion reaction | 66.80 | 9.74 | 19 | 208663 | 28 | 46477352 |
| Blood pressure increased | 65.46 | 9.74 | 859 | 207823 | 125807 | 46351573 |
| Pregnancy | 65.27 | 9.74 | 20 | 208662 | 27117 | 46450263 |
| Dizziness | 64.30 | 9.74 | 1983 | 206699 | 338431 | 46138949 |
| Chest pain | 63.75 | 9.74 | 1125 | 207557 | 175199 | 46302181 |
| Blood pressure inadequately controlled | 61.95 | 9.74 | 87 | 208595 | 4319 | 46473061 |
| Premature delivery | 61.39 | 9.74 | 12 | 208670 | 22057 | 46455323 |
| Swelling face | 60.75 | 9.74 | 426 | 208256 | 52633 | 46424747 |
| Mental status changes | 60.05 | 9.74 | 332 | 208350 | 37756 | 46439624 |
| Product use issue | 59.96 | 9.74 | 219 | 208463 | 94425 | 46382955 |
| Foetal exposure during pregnancy | 57.38 | 9.74 | 33 | 208649 | 30714 | 46446666 |
| Labile blood pressure | 55.53 | 9.74 | 52 | 208630 | 1651 | 46475729 |
| Agranulocytosis | 53.99 | 9.74 | 16 | 208666 | 22169 | 46455211 |
| Leukopenia | 53.25 | 9.74 | 144 | 208538 | 68199 | 46409181 |
| Hypovolaemia | 52.32 | 9.74 | 128 | 208554 | 9760 | 46467620 |
| Overdose | 52.23 | 9.74 | 256 | 208426 | 101723 | 46375657 |
| Chronic kidney disease | 51.48 | 9.74 | 336 | 208346 | 40535 | 46436845 |
| Cytomegalovirus infection | 50.18 | 9.74 | 10 | 208672 | 18134 | 46459246 |
| Coronary artery bypass | 49.74 | 9.74 | 58 | 208624 | 2387 | 46474993 |
| Infection | 49.69 | 9.74 | 371 | 208311 | 133221 | 46344159 |
| Cough | 49.07 | 9.74 | 1362 | 207320 | 228887 | 46248493 |
| Malignant neoplasm progression | 47.49 | 9.74 | 141 | 208541 | 64785 | 46412595 |
| Intentional self-injury | 46.45 | 9.74 | 25 | 208657 | 24141 | 46453239 |
| Type 2 diabetes mellitus | 46.39 | 9.74 | 194 | 208488 | 19681 | 46457699 |
| Angina unstable | 44.60 | 9.74 | 102 | 208580 | 7446 | 46469934 |
| Product complaint | 44.43 | 9.74 | 137 | 208545 | 11964 | 46465416 |
| Diarrhoea | 44.39 | 9.74 | 2984 | 205698 | 556618 | 45920762 |
| Drug reaction with eosinophilia and systemic symptoms | 44.32 | 9.74 | 40 | 208642 | 29508 | 46447872 |
| Rheumatoid factor positive | 44.21 | 9.74 | 18 | 208664 | 20443 | 46456937 |
| Product use in unapproved indication | 43.73 | 9.74 | 231 | 208451 | 90042 | 46387338 |
| Therapeutic product effect incomplete | 43.69 | 9.74 | 190 | 208492 | 77963 | 46399417 |
| Coma | 43.19 | 9.74 | 126 | 208556 | 58223 | 46419157 |
| Glossodynia | 43.07 | 9.74 | 83 | 208599 | 44290 | 46433090 |
| Hepatocellular injury | 43.05 | 9.74 | 41 | 208641 | 29481 | 46447899 |
| Mucosal inflammation | 42.27 | 9.74 | 68 | 208614 | 38908 | 46438472 |
| Suicide attempt | 41.35 | 9.74 | 118 | 208564 | 54918 | 46422462 |
| Anti-cyclic citrullinated peptide antibody positive | 41.11 | 9.74 | 17 | 208665 | 19128 | 46458252 |
| Hypotension | 40.97 | 9.74 | 1344 | 207338 | 231245 | 46246135 |
| Oxygen saturation decreased | 39.98 | 9.74 | 166 | 208516 | 68998 | 46408382 |
| Asthenia | 39.83 | 9.74 | 1735 | 206947 | 309340 | 46168040 |
| Therapeutic product effect decreased | 39.66 | 9.74 | 212 | 208470 | 82389 | 46394991 |
| Foetal methotrexate syndrome | 39.53 | 9.74 | 14 | 208668 | 56 | 46477324 |
| Intentional overdose | 39.35 | 9.74 | 153 | 208529 | 64791 | 46412589 |
| Premature baby | 39.03 | 9.74 | 16 | 208666 | 18096 | 46459284 |
| Sopor | 38.87 | 9.74 | 20 | 208662 | 19808 | 46457572 |
| Thrombocytopenia | 38.74 | 9.74 | 370 | 208312 | 126211 | 46351169 |
| Hepatic enzyme increased | 38.67 | 9.74 | 211 | 208471 | 81576 | 46395804 |
| Altered state of consciousness | 38.24 | 9.74 | 29 | 208653 | 23319 | 46454061 |
| Psoriasis | 37.27 | 9.74 | 525 | 208157 | 78079 | 46399301 |
| Arthralgia | 37.05 | 9.74 | 1296 | 207386 | 363307 | 46114073 |
| Caesarean section | 36.87 | 9.74 | 14 | 208668 | 16589 | 46460791 |
| Renal injury | 35.94 | 9.74 | 109 | 208573 | 9432 | 46467948 |
| Nausea | 35.82 | 9.74 | 3550 | 205132 | 683904 | 45793476 |
| Inflammation | 35.62 | 9.74 | 106 | 208576 | 48675 | 46428705 |
| Pericarditis | 35.16 | 9.74 | 33 | 208649 | 23894 | 46453486 |
| Musculoskeletal stiffness | 35.07 | 9.74 | 275 | 208407 | 97718 | 46379662 |
| Joint swelling | 34.90 | 9.74 | 527 | 208155 | 165546 | 46311834 |
| Gastrointestinal haemorrhage | 34.78 | 9.74 | 512 | 208170 | 76861 | 46400519 |
| Glycosylated haemoglobin increased | 34.38 | 9.74 | 117 | 208565 | 10759 | 46466621 |
| Transient ischaemic attack | 34.14 | 9.74 | 270 | 208412 | 34633 | 46442747 |
| Atrioventricular block second degree | 33.99 | 9.74 | 61 | 208621 | 3738 | 46473642 |
| Pulseless electrical activity | 33.98 | 9.74 | 89 | 208593 | 7078 | 46470302 |
| Angina pectoris | 33.03 | 9.74 | 219 | 208463 | 26556 | 46450824 |
| Somatic delusion | 33.01 | 9.74 | 25 | 208657 | 588 | 46476792 |
| Ischaemic cardiomyopathy | 32.99 | 9.74 | 49 | 208633 | 2561 | 46474819 |
| Pancreatitis acute | 32.87 | 9.74 | 207 | 208475 | 24665 | 46452715 |
| Arteriosclerosis | 32.81 | 9.74 | 107 | 208575 | 9626 | 46467754 |
| Status epilepticus | 32.38 | 9.74 | 11 | 208671 | 13968 | 46463412 |
| Epilepsy | 32.30 | 9.74 | 35 | 208647 | 23703 | 46453677 |
| Toxic skin eruption | 31.90 | 9.74 | 8 | 208674 | 12379 | 46465001 |
| Hypoaldosteronism | 31.75 | 9.74 | 16 | 208666 | 175 | 46477205 |
| Arthropathy | 31.58 | 9.74 | 235 | 208447 | 84465 | 46392915 |
| Pneumonia | 30.96 | 9.74 | 1371 | 207311 | 374949 | 46102431 |
| Blood glucose decreased | 30.66 | 9.74 | 166 | 208516 | 18726 | 46458654 |
| Atrioventricular block first degree | 30.55 | 9.74 | 78 | 208604 | 6108 | 46471272 |
| Wound | 30.54 | 9.74 | 94 | 208588 | 42708 | 46434672 |
| Cardiac disorder | 30.46 | 9.74 | 315 | 208367 | 43543 | 46433837 |
| Device expulsion | 29.91 | 9.74 | 48 | 208634 | 27494 | 46449886 |
| Atrial fibrillation | 29.61 | 9.74 | 638 | 208044 | 102952 | 46374428 |
| Hyperlipidaemia | 29.48 | 9.74 | 162 | 208520 | 18377 | 46459003 |
| Nasopharyngitis | 29.24 | 9.74 | 498 | 208184 | 153500 | 46323880 |
| Bone marrow failure | 29.22 | 9.74 | 55 | 208627 | 29614 | 46447766 |
| Drug resistance | 29.18 | 9.74 | 21 | 208661 | 17347 | 46460033 |
| Blood loss anaemia | 28.78 | 9.74 | 94 | 208588 | 8463 | 46468917 |
| Depressed level of consciousness | 28.22 | 9.74 | 113 | 208569 | 47456 | 46429924 |
| Blood sodium decreased | 28.20 | 9.74 | 180 | 208502 | 21546 | 46455834 |
| Condition aggravated | 28.19 | 9.74 | 857 | 207825 | 244195 | 46233185 |
| Cardiomyopathy | 27.98 | 9.74 | 144 | 208538 | 15929 | 46461451 |
| Neutrophil count decreased | 27.81 | 9.74 | 100 | 208582 | 43326 | 46434054 |
| Infective pulmonary exacerbation of cystic fibrosis | 27.79 | 9.74 | 7 | 208675 | 10800 | 46466580 |
| Hepatotoxicity | 27.72 | 9.74 | 43 | 208639 | 24966 | 46452414 |
| Pneumocystis jirovecii pneumonia | 27.56 | 9.74 | 17 | 208665 | 15231 | 46462149 |
| Erythema | 27.39 | 9.74 | 461 | 208221 | 142359 | 46335021 |
| Vision blurred | 26.80 | 9.74 | 503 | 208179 | 79205 | 46398175 |
| Arterial occlusive disease | 26.29 | 9.74 | 63 | 208619 | 4741 | 46472639 |
| Alopecia | 26.25 | 9.74 | 540 | 208142 | 161874 | 46315506 |
| Gamma-glutamyltransferase increased | 26.15 | 9.74 | 65 | 208617 | 31675 | 46445705 |
| Sight disability | 25.64 | 9.74 | 12 | 208670 | 110 | 46477270 |
| Blood potassium increased | 25.48 | 9.74 | 146 | 208536 | 16821 | 46460559 |
| Coronary artery occlusion | 25.47 | 9.74 | 87 | 208595 | 8015 | 46469365 |
| Pancytopenia | 25.43 | 9.74 | 250 | 208432 | 84808 | 46392572 |
| Colitis ulcerative | 25.42 | 9.74 | 25 | 208657 | 17707 | 46459673 |
| Colitis ischaemic | 25.30 | 9.74 | 101 | 208581 | 10031 | 46467349 |
| Abnormal dreams | 25.30 | 9.74 | 102 | 208580 | 10177 | 46467203 |
| Progressive multifocal leukoencephalopathy | 24.48 | 9.74 | 10 | 208672 | 11336 | 46466044 |
| Dysgeusia | 24.07 | 9.74 | 282 | 208400 | 40209 | 46437171 |
| Factor VII deficiency | 23.86 | 9.74 | 8 | 208674 | 26 | 46477354 |
| Septic shock | 23.85 | 9.74 | 156 | 208526 | 57737 | 46419643 |
| Neurotoxicity | 23.82 | 9.74 | 16 | 208666 | 13701 | 46463679 |
| Foetal death | 23.80 | 9.74 | 5 | 208677 | 8738 | 46468642 |
| Drug dispensed to wrong patient | 23.64 | 9.74 | 14 | 208668 | 215 | 46477165 |
| Tongue oedema | 23.52 | 9.74 | 54 | 208628 | 3952 | 46473428 |
| Synostosis | 23.34 | 9.74 | 9 | 208673 | 48 | 46477332 |
| Fall | 23.22 | 9.74 | 1739 | 206943 | 327358 | 46150022 |
| Lung disorder | 23.16 | 9.74 | 107 | 208575 | 43197 | 46434183 |
| Lymphopenia | 22.58 | 9.74 | 21 | 208661 | 15272 | 46462108 |
| Thermohypoaesthesia | 22.51 | 9.74 | 11 | 208671 | 112 | 46477268 |
| Drug eruption | 22.39 | 9.74 | 38 | 208644 | 21291 | 46456089 |
| Lymphomatoid papulosis | 22.26 | 9.74 | 11 | 208671 | 115 | 46477265 |
| Suspected suicide | 22.22 | 9.74 | 58 | 208624 | 4603 | 46472777 |
| Cholestasis | 22.22 | 9.74 | 55 | 208627 | 26838 | 46450542 |
| Eosinophilic oesophagitis | 22.05 | 9.74 | 13 | 208669 | 198 | 46477182 |
| Osmolar gap increased | 21.80 | 9.74 | 7 | 208675 | 19 | 46477361 |
| Liver disorder | 21.76 | 9.74 | 89 | 208593 | 37157 | 46440223 |
| Memory impairment | 21.67 | 9.74 | 475 | 208207 | 76862 | 46400518 |
| Alanine aminotransferase increased | 21.67 | 9.74 | 272 | 208410 | 88179 | 46389201 |
| Encephalomalacia | 21.54 | 9.74 | 18 | 208664 | 490 | 46476890 |
| Salivary gland enlargement | 21.43 | 9.74 | 16 | 208666 | 368 | 46477012 |
| Rheumatoid nodule | 21.07 | 9.74 | 7 | 208675 | 9013 | 46468367 |
| Gangrene | 20.94 | 9.74 | 57 | 208625 | 4638 | 46472742 |
| Bone erosion | 20.91 | 9.74 | 8 | 208674 | 9435 | 46467945 |
| Sinus arrhythmia | 20.85 | 9.74 | 28 | 208654 | 1332 | 46476048 |
| Aspergillus infection | 20.81 | 9.74 | 3 | 208679 | 6887 | 46470493 |
| Asthma | 20.78 | 9.74 | 286 | 208396 | 91256 | 46386124 |
| Rash maculo-papular | 20.76 | 9.74 | 60 | 208622 | 27814 | 46449566 |
| Neutropenic sepsis | 20.58 | 9.74 | 15 | 208667 | 12309 | 46465071 |
| Eosinophilia | 20.39 | 9.74 | 34 | 208648 | 19183 | 46458197 |
| Nodular rash | 20.11 | 9.74 | 12 | 208670 | 187 | 46477193 |
| Muscle spasms | 20.01 | 9.74 | 705 | 207977 | 122408 | 46354972 |
| Myocardial ischaemia | 20.00 | 9.74 | 111 | 208571 | 12638 | 46464742 |
| Blood potassium decreased | 19.99 | 9.74 | 259 | 208423 | 37804 | 46439576 |
| Nodal rhythm | 19.85 | 9.74 | 31 | 208651 | 1694 | 46475686 |
| Syncope | 19.82 | 9.74 | 611 | 208071 | 104192 | 46373188 |
| Dilatation atrial | 19.77 | 9.74 | 35 | 208647 | 2122 | 46475258 |
| Extrapyramidal disorder | 19.76 | 9.74 | 13 | 208669 | 11255 | 46466125 |
| Product quality issue | 19.76 | 9.74 | 245 | 208437 | 35403 | 46441977 |
| Graft versus host disease | 19.60 | 9.74 | 3 | 208679 | 6585 | 46470795 |
| Adactyly | 19.57 | 9.74 | 7 | 208675 | 29 | 46477351 |
| Diabetic ketoacidosis | 19.56 | 9.74 | 144 | 208538 | 18066 | 46459314 |
| Spinal stenosis | 19.54 | 9.74 | 109 | 208573 | 12434 | 46464946 |
| Dysphagia | 19.54 | 9.74 | 468 | 208214 | 76844 | 46400536 |
| Tuberculosis | 19.18 | 9.74 | 11 | 208671 | 10254 | 46467126 |
| Abortion induced | 19.16 | 9.74 | 11 | 208671 | 10249 | 46467131 |
| Tenosynovitis | 19.07 | 9.74 | 5 | 208677 | 7510 | 46469870 |
| Diabetic neuropathy | 18.94 | 9.74 | 48 | 208634 | 3741 | 46473639 |
| Blood pressure fluctuation | 18.91 | 9.74 | 71 | 208611 | 30377 | 46447003 |
| Hepatitis | 18.81 | 9.74 | 77 | 208605 | 32138 | 46445242 |
| Haematotoxicity | 18.80 | 9.74 | 4 | 208678 | 6929 | 46470451 |
| Ventricular hypertrophy | 18.74 | 9.74 | 48 | 208634 | 3766 | 46473614 |
| Feeling abnormal | 18.59 | 9.74 | 709 | 207973 | 124351 | 46353029 |
| Haemophagocytic lymphohistiocytosis | 18.58 | 9.74 | 7 | 208675 | 8335 | 46469045 |
| Thrombotic microangiopathy | 18.45 | 9.74 | 7 | 208675 | 8299 | 46469081 |
| Upper gastrointestinal haemorrhage | 18.34 | 9.74 | 133 | 208549 | 16605 | 46460775 |
| Fear of eating | 18.25 | 9.74 | 14 | 208668 | 336 | 46477044 |
| Muscle rigidity | 18.15 | 9.74 | 11 | 208671 | 9950 | 46467430 |
| Nervousness | 18.13 | 9.74 | 201 | 208481 | 28274 | 46449106 |
| BRASH syndrome | 17.97 | 9.74 | 9 | 208673 | 97 | 46477283 |
| International normalised ratio increased | 17.94 | 9.74 | 302 | 208380 | 46581 | 46430799 |
| Body height decreased | 17.88 | 9.74 | 88 | 208594 | 9564 | 46467816 |
| Allergic cough | 17.84 | 9.74 | 16 | 208666 | 480 | 46476900 |
| Chronic obstructive pulmonary disease | 17.78 | 9.74 | 359 | 208323 | 57274 | 46420106 |
| Drug clearance decreased | 17.67 | 9.74 | 23 | 208659 | 1061 | 46476319 |
| Hepatic ischaemia | 17.57 | 9.74 | 16 | 208666 | 490 | 46476890 |
| Peritonitis | 17.39 | 9.74 | 42 | 208640 | 20672 | 46456708 |
| Oral herpes | 17.35 | 9.74 | 38 | 208644 | 19352 | 46458028 |
| Red blood cell sedimentation rate increased | 17.24 | 9.74 | 49 | 208633 | 22840 | 46454540 |
| Gout | 17.24 | 9.74 | 98 | 208584 | 11258 | 46466122 |
| Dystonia | 17.17 | 9.74 | 15 | 208667 | 11242 | 46466138 |
| Shock | 17.17 | 9.74 | 161 | 208521 | 21684 | 46455696 |
| Uraemic encephalopathy | 17.06 | 9.74 | 11 | 208671 | 198 | 46477182 |
| Injury | 16.99 | 9.74 | 284 | 208398 | 43743 | 46433637 |
| Stridor | 16.93 | 9.74 | 41 | 208641 | 3106 | 46474274 |
| Myalgia | 16.93 | 9.74 | 692 | 207990 | 122396 | 46354984 |
| Oedema mouth | 16.89 | 9.74 | 36 | 208646 | 2505 | 46474875 |
| Tachycardia | 16.75 | 9.74 | 329 | 208353 | 99293 | 46378087 |
| Stomatitis | 16.74 | 9.74 | 210 | 208472 | 68087 | 46409293 |
| Live birth | 16.70 | 9.74 | 13 | 208669 | 10317 | 46467063 |
| Charles Bonnet syndrome | 16.63 | 9.74 | 5 | 208677 | 10 | 46477370 |
| Diverticulum | 16.55 | 9.74 | 96 | 208586 | 11110 | 46466270 |
| Hypergammaglobulinaemia | 16.53 | 9.74 | 15 | 208667 | 457 | 46476923 |
| Muscle relaxant therapy | 16.31 | 9.74 | 9 | 208673 | 120 | 46477260 |
| Suspected suicide attempt | 16.24 | 9.74 | 9 | 208673 | 121 | 46477259 |
| Lacunar infarction | 16.24 | 9.74 | 43 | 208639 | 3442 | 46473938 |
| Fluid intake reduced | 16.16 | 9.74 | 42 | 208640 | 3324 | 46474056 |
| Premature labour | 16.12 | 9.74 | 16 | 208666 | 11283 | 46466097 |
| Peripheral vascular disorder | 16.08 | 9.74 | 61 | 208621 | 5916 | 46471464 |
| Essential hypertension | 16.01 | 9.74 | 49 | 208633 | 4261 | 46473119 |
| Body temperature decreased | 15.89 | 9.74 | 22 | 208660 | 13387 | 46463993 |
| Device difficult to use | 15.80 | 9.74 | 8 | 208674 | 7996 | 46469384 |
| Therapy cessation | 15.62 | 9.74 | 185 | 208497 | 26444 | 46450936 |
| Anhedonia | 15.56 | 9.74 | 89 | 208593 | 10246 | 46467134 |
| Transcription medication error | 15.51 | 9.74 | 10 | 208672 | 180 | 46477200 |
| Acne | 15.48 | 9.74 | 42 | 208640 | 19877 | 46457503 |
| Device dislocation | 15.47 | 9.74 | 48 | 208634 | 21754 | 46455626 |
| Body temperature increased | 15.42 | 9.74 | 58 | 208624 | 24803 | 46452577 |
| Blood pressure systolic abnormal | 15.34 | 9.74 | 3 | 208679 | 5514 | 46471866 |
| Pneumonitis | 15.33 | 9.74 | 70 | 208612 | 28350 | 46449030 |
| Electrocardiogram T wave abnormal | 15.32 | 9.74 | 33 | 208649 | 2313 | 46475067 |
| Sedation | 15.17 | 9.74 | 52 | 208630 | 22858 | 46454522 |
| Low birth weight baby | 15.02 | 9.74 | 3 | 208679 | 5431 | 46471949 |
| Liver function test increased | 14.99 | 9.74 | 52 | 208630 | 22774 | 46454606 |
| Mydriasis | 14.99 | 9.74 | 15 | 208667 | 10538 | 46466842 |
| Weight decreased | 14.81 | 9.74 | 1114 | 207568 | 209735 | 46267645 |
| Accelerated hypertension | 14.75 | 9.74 | 13 | 208669 | 381 | 46476999 |
| Full blood count decreased | 14.70 | 9.74 | 158 | 208524 | 22053 | 46455327 |
| Epstein-Barr virus infection | 14.60 | 9.74 | 6 | 208676 | 6778 | 46470602 |
| Lichen planus | 14.60 | 9.74 | 28 | 208654 | 1805 | 46475575 |
| Transient psychosis | 14.57 | 9.74 | 6 | 208676 | 39 | 46477341 |
| Generalised tonic-clonic seizure | 14.51 | 9.74 | 67 | 208615 | 27055 | 46450325 |
| Neuroleptic malignant syndrome | 14.47 | 9.74 | 17 | 208665 | 11105 | 46466275 |
| Electrocardiogram T wave peaked | 14.47 | 9.74 | 10 | 208672 | 203 | 46477177 |
| Oedema peripheral | 14.46 | 9.74 | 862 | 207820 | 158844 | 46318536 |
| Transplant rejection | 14.38 | 9.74 | 13 | 208669 | 9583 | 46467797 |
| Productive cough | 14.35 | 9.74 | 151 | 208531 | 50564 | 46426816 |
| Pre-eclampsia | 14.33 | 9.74 | 9 | 208673 | 7985 | 46469395 |
| Cerebral atrophy | 14.27 | 9.74 | 50 | 208632 | 4666 | 46472714 |
| Panniculitis | 14.09 | 9.74 | 4 | 208678 | 5700 | 46471680 |
| Product coating issue | 14.08 | 9.74 | 6 | 208676 | 43 | 46477337 |
| Application site nodule | 14.02 | 9.74 | 4 | 208678 | 6 | 46477374 |
| Urethral prolapse | 14.02 | 9.74 | 4 | 208678 | 6 | 46477374 |
| Product substitution issue | 14.00 | 9.74 | 115 | 208567 | 14916 | 46462464 |
| Metastases to liver | 13.98 | 9.74 | 43 | 208639 | 19542 | 46457838 |
| Blood pressure abnormal | 13.92 | 9.74 | 98 | 208584 | 12119 | 46465261 |
| Mitral valve incompetence | 13.86 | 9.74 | 137 | 208545 | 18715 | 46458665 |
| Respiratory depression | 13.78 | 9.74 | 19 | 208663 | 11581 | 46465799 |
| Shock haemorrhagic | 13.76 | 9.74 | 11 | 208671 | 8613 | 46468767 |
| Forced expiratory volume decreased | 13.73 | 9.74 | 3 | 208679 | 5101 | 46472279 |
| Hepatorenal syndrome | 13.65 | 9.74 | 27 | 208655 | 1781 | 46475599 |
| Pathogen resistance | 13.64 | 9.74 | 5 | 208677 | 6055 | 46471325 |
| Oral candidiasis | 13.60 | 9.74 | 37 | 208645 | 17495 | 46459885 |
| Hypophagia | 13.58 | 9.74 | 195 | 208487 | 29111 | 46448269 |
| Schizophrenia | 13.58 | 9.74 | 11 | 208671 | 8557 | 46468823 |
| Dizziness postural | 13.57 | 9.74 | 61 | 208621 | 6385 | 46470995 |
| Ventricular fibrillation | 13.56 | 9.74 | 93 | 208589 | 11403 | 46465977 |
| Cerebral thrombosis | 13.55 | 9.74 | 26 | 208656 | 1677 | 46475703 |
| Factor VIII inhibition | 13.52 | 9.74 | 6 | 208676 | 48 | 46477332 |
| Myelosuppression | 13.36 | 9.74 | 9 | 208673 | 7694 | 46469686 |
| Pulmonary arterial hypertension | 13.31 | 9.74 | 65 | 208617 | 25863 | 46451517 |
| Paramnesia | 13.30 | 9.74 | 4 | 208678 | 8 | 46477372 |
| Autonomic failure syndrome | 13.25 | 9.74 | 3 | 208679 | 0 | 46477380 |
| Acute myeloid leukaemia | 13.24 | 9.74 | 32 | 208650 | 15746 | 46461634 |
| Catheterisation cardiac | 13.20 | 9.74 | 44 | 208638 | 4003 | 46473377 |
| Fear | 13.11 | 9.74 | 120 | 208562 | 16052 | 46461328 |
| Nephrogenic systemic fibrosis | 13.09 | 9.74 | 49 | 208633 | 4723 | 46472657 |
| Pharyngitis | 12.98 | 9.74 | 38 | 208644 | 17545 | 46459835 |
| Blood electrolytes abnormal | 12.98 | 9.74 | 19 | 208663 | 980 | 46476400 |
| Bezoar | 12.97 | 9.74 | 23 | 208659 | 1396 | 46475984 |
| Feeling jittery | 12.95 | 9.74 | 89 | 208593 | 10919 | 46466461 |
| Dry mouth | 12.83 | 9.74 | 329 | 208353 | 54597 | 46422783 |
| Stevens-Johnson syndrome | 12.79 | 9.74 | 57 | 208625 | 23240 | 46454140 |
| Carotid artery stenosis | 12.75 | 9.74 | 51 | 208631 | 5069 | 46472311 |
| Osteoporosis | 12.71 | 9.74 | 118 | 208564 | 40490 | 46436890 |
| Depression | 12.67 | 9.74 | 903 | 207779 | 169201 | 46308179 |
| Product availability issue | 12.64 | 9.74 | 20 | 208662 | 1105 | 46476275 |
| Cytokine release syndrome | 12.61 | 9.74 | 6 | 208676 | 6217 | 46471163 |
| Pharyngeal oedema | 12.57 | 9.74 | 109 | 208573 | 14362 | 46463018 |
| Chorioretinitis | 12.55 | 9.74 | 11 | 208671 | 320 | 46477060 |
| Pneumonia viral | 12.52 | 9.74 | 7 | 208675 | 6617 | 46470763 |
| Craniosynostosis | 12.50 | 9.74 | 8 | 208674 | 142 | 46477238 |
| Device related infection | 12.47 | 9.74 | 50 | 208632 | 20991 | 46456389 |
| Mobility decreased | 12.46 | 9.74 | 193 | 208489 | 60401 | 46416979 |
| Facial nerve disorder | 12.38 | 9.74 | 14 | 208668 | 557 | 46476823 |
| Second primary malignancy | 12.38 | 9.74 | 7 | 208675 | 6577 | 46470803 |
| Rectal haemorrhage | 12.37 | 9.74 | 240 | 208442 | 38015 | 46439365 |
| Therapeutic response unexpected | 12.22 | 9.74 | 115 | 208567 | 15501 | 46461879 |
| Flatulence | 12.16 | 9.74 | 189 | 208493 | 28689 | 46448691 |
| Administration site discomfort | 12.14 | 9.74 | 7 | 208675 | 102 | 46477278 |
| Faeces pale | 12.04 | 9.74 | 23 | 208659 | 1479 | 46475901 |
| Blood creatinine increased | 12.03 | 9.74 | 436 | 208246 | 75967 | 46401413 |
| Polyneuropathy | 11.99 | 9.74 | 21 | 208661 | 11623 | 46465757 |
| Mouth swelling | 11.94 | 9.74 | 40 | 208642 | 3649 | 46473731 |
| Ageusia | 11.91 | 9.74 | 90 | 208592 | 11382 | 46465998 |
| Palmar-plantar erythrodysaesthesia syndrome | 11.86 | 9.74 | 49 | 208633 | 20402 | 46456978 |
| Gait disturbance | 11.84 | 9.74 | 777 | 207905 | 144486 | 46332894 |
| Acute interstitial pneumonitis | 11.81 | 9.74 | 15 | 208667 | 675 | 46476705 |
| Raynaud's phenomenon | 11.79 | 9.74 | 21 | 208661 | 1279 | 46476101 |
| Nephropathy | 11.79 | 9.74 | 49 | 208633 | 4956 | 46472424 |
| Laryngotracheal oedema | 11.72 | 9.74 | 5 | 208677 | 36 | 46477344 |
| Retching | 11.68 | 9.74 | 99 | 208583 | 12958 | 46464422 |
| Expired product administered | 11.68 | 9.74 | 53 | 208629 | 5569 | 46471811 |
| Non-cardiac chest pain | 11.68 | 9.74 | 56 | 208626 | 6022 | 46471358 |
| Osteonecrosis of jaw | 11.63 | 9.74 | 98 | 208584 | 34304 | 46443076 |
| Eosinophilic pneumonia acute | 11.62 | 9.74 | 11 | 208671 | 354 | 46477026 |
| Balance disorder | 11.62 | 9.74 | 374 | 208308 | 64147 | 46413233 |
| Diffuse large B-cell lymphoma | 11.62 | 9.74 | 6 | 208676 | 5932 | 46471448 |
| Cholelithiasis | 11.61 | 9.74 | 240 | 208442 | 38441 | 46438939 |
| Rash | 11.59 | 9.74 | 1406 | 207276 | 355106 | 46122274 |
| Poor venous access | 11.58 | 9.74 | 12 | 208670 | 8296 | 46469084 |
| Poisoning deliberate | 11.56 | 9.74 | 11 | 208671 | 7915 | 46469465 |
| Lymphocyte count decreased | 11.55 | 9.74 | 67 | 208615 | 25522 | 46451858 |
| Burn oesophageal | 11.51 | 9.74 | 8 | 208674 | 164 | 46477216 |
| Gastric ulcer helicobacter | 11.49 | 9.74 | 4 | 208678 | 15 | 46477365 |
| Ovarian cyst | 11.49 | 9.74 | 29 | 208653 | 14058 | 46463322 |
| Diabetic gastroparesis | 11.49 | 9.74 | 9 | 208673 | 223 | 46477157 |
| Back disorder | 11.41 | 9.74 | 75 | 208607 | 9066 | 46468314 |
| Immune thrombocytopenia | 11.38 | 9.74 | 12 | 208670 | 8229 | 46469151 |
| Multimorbidity | 11.34 | 9.74 | 15 | 208667 | 703 | 46476677 |
| Tonsillitis | 11.34 | 9.74 | 4 | 208678 | 4960 | 46472420 |
| Upper airway obstruction | 11.30 | 9.74 | 13 | 208669 | 527 | 46476853 |
| Cardioactive drug level increased | 11.26 | 9.74 | 27 | 208655 | 2032 | 46475348 |
| Apparent death | 11.22 | 9.74 | 21 | 208661 | 1329 | 46476051 |
| Renal tubular acidosis | 11.19 | 9.74 | 23 | 208659 | 1560 | 46475820 |
| Pancreatic calcification | 11.18 | 9.74 | 3 | 208679 | 3 | 46477377 |
| Ischaemic neuropathy | 11.18 | 9.74 | 3 | 208679 | 3 | 46477377 |
| Gastrooesophageal reflux disease | 11.16 | 9.74 | 422 | 208260 | 73922 | 46403458 |
| Asymptomatic bacteriuria | 11.14 | 9.74 | 6 | 208676 | 76 | 46477304 |
| Blood urea increased | 11.09 | 9.74 | 167 | 208515 | 25185 | 46452195 |
| Hypogeusia | 11.03 | 9.74 | 18 | 208664 | 1021 | 46476359 |
| Respiratory disorder | 11.02 | 9.74 | 74 | 208608 | 27226 | 46450154 |
| Visual acuity reduced | 11.00 | 9.74 | 149 | 208533 | 21964 | 46455416 |
| Rotator cuff repair | 10.98 | 9.74 | 22 | 208660 | 1465 | 46475915 |
| Bundle branch block left | 10.91 | 9.74 | 57 | 208625 | 6342 | 46471038 |
| Tarsal tunnel syndrome | 10.84 | 9.74 | 14 | 208668 | 641 | 46476739 |
| Product solubility abnormal | 10.78 | 9.74 | 16 | 208666 | 836 | 46476544 |
| Macular fibrosis | 10.77 | 9.74 | 11 | 208671 | 389 | 46476991 |
| Erythema marginatum | 10.75 | 9.74 | 4 | 208678 | 19 | 46477361 |
| Abdominal discomfort | 10.75 | 9.74 | 559 | 208123 | 150606 | 46326774 |
| Disseminated intravascular coagulation | 10.74 | 9.74 | 46 | 208636 | 18959 | 46458421 |
| Demyelination | 10.74 | 9.74 | 6 | 208676 | 5674 | 46471706 |
| Glomerulonephritis membranous | 10.72 | 9.74 | 13 | 208669 | 558 | 46476822 |
| Immunodeficiency | 10.67 | 9.74 | 27 | 208655 | 13079 | 46464301 |
| Blood urea abnormal | 10.66 | 9.74 | 13 | 208669 | 561 | 46476819 |
| Optic ischaemic neuropathy | 10.66 | 9.74 | 17 | 208665 | 946 | 46476434 |
| Eye swelling | 10.64 | 9.74 | 137 | 208545 | 19966 | 46457414 |
| Infusion site pain | 10.62 | 9.74 | 18 | 208664 | 10089 | 46467291 |
| Hyperbilirubinaemia | 10.59 | 9.74 | 19 | 208663 | 10419 | 46466961 |
| Acute generalised exanthematous pustulosis | 10.59 | 9.74 | 16 | 208666 | 9389 | 46467991 |
| Osteoarthritis | 10.52 | 9.74 | 357 | 208325 | 61668 | 46415712 |
| High density lipoprotein abnormal | 10.49 | 9.74 | 5 | 208677 | 48 | 46477332 |
| Venoocclusive liver disease | 10.46 | 9.74 | 3 | 208679 | 4248 | 46473132 |
| Chromatopsia | 10.46 | 9.74 | 12 | 208670 | 485 | 46476895 |
| Ventricular tachycardia | 10.45 | 9.74 | 119 | 208563 | 16848 | 46460532 |
| Unresponsive to stimuli | 10.45 | 9.74 | 202 | 208480 | 31972 | 46445408 |
| Urine abnormality | 10.44 | 9.74 | 6 | 208676 | 5588 | 46471792 |
| Insomnia | 10.37 | 9.74 | 864 | 207818 | 164060 | 46313320 |
| Hyponatraemia | 10.34 | 9.74 | 553 | 208129 | 100779 | 46376601 |
| SUNCT syndrome | 10.32 | 9.74 | 3 | 208679 | 5 | 46477375 |
| Retroperitoneal oedema | 10.27 | 9.74 | 4 | 208678 | 22 | 46477358 |
| Confusional state | 10.27 | 9.74 | 839 | 207843 | 159053 | 46318327 |
| Blood lactate dehydrogenase increased | 10.18 | 9.74 | 52 | 208630 | 20448 | 46456932 |
| Fatigue | 10.10 | 9.74 | 2957 | 205725 | 605740 | 45871640 |
| Blood glucose fluctuation | 10.09 | 9.74 | 41 | 208641 | 4105 | 46473275 |
| Occult blood positive | 10.08 | 9.74 | 37 | 208645 | 3533 | 46473847 |
| Choroidal effusion | 10.03 | 9.74 | 11 | 208671 | 423 | 46476957 |
| Umbilical hernia, obstructive | 9.98 | 9.74 | 3 | 208679 | 6 | 46477374 |
| Jaundice cholestatic | 9.96 | 9.74 | 5 | 208677 | 5024 | 46472356 |
| Haemodialysis | 9.96 | 9.74 | 73 | 208609 | 9144 | 46468236 |
| Product residue present | 9.94 | 9.74 | 39 | 208643 | 3843 | 46473537 |
| Sarcoma | 9.92 | 9.74 | 11 | 208671 | 428 | 46476952 |
| Haemorrhagic hepatic cyst | 9.85 | 9.74 | 4 | 208678 | 25 | 46477355 |
| Fracture | 9.85 | 9.74 | 39 | 208643 | 16432 | 46460948 |
| Folliculitis | 9.78 | 9.74 | 8 | 208674 | 6195 | 46471185 |
| Urinary tract candidiasis | 9.75 | 9.74 | 12 | 208670 | 523 | 46476857 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Angioedema | 10461.53 | 10.57 | 4893 | 190875 | 29491 | 29727219 |
| Cardiac failure congestive | 579.70 | 10.57 | 1525 | 194243 | 82882 | 29673828 |
| Myocardial infarction | 554.95 | 10.57 | 1943 | 193825 | 123682 | 29633028 |
| Swollen tongue | 517.36 | 10.57 | 529 | 195239 | 12663 | 29744047 |
| Hyperkalaemia | 508.61 | 10.57 | 1246 | 194522 | 64764 | 29691946 |
| Lip swelling | 479.85 | 10.57 | 500 | 195268 | 12244 | 29744466 |
| Coronary artery disease | 341.69 | 10.57 | 899 | 194869 | 48813 | 29707897 |
| Acute kidney injury | 283.32 | 10.57 | 2881 | 192887 | 270961 | 29485749 |
| Drug abuse | 270.62 | 10.57 | 99 | 195669 | 81973 | 29674737 |
| Off label use | 252.16 | 10.57 | 814 | 194954 | 248476 | 29508234 |
| Pyrexia | 248.44 | 10.57 | 1037 | 194731 | 293452 | 29463258 |
| Cerebrovascular accident | 239.94 | 10.57 | 1131 | 194637 | 82346 | 29674364 |
| Swelling face | 218.82 | 10.57 | 450 | 195318 | 20754 | 29735956 |
| Febrile neutropenia | 217.27 | 10.57 | 226 | 195542 | 106467 | 29650243 |
| Completed suicide | 200.01 | 10.57 | 1222 | 194546 | 98270 | 29658440 |
| General physical health deterioration | 198.68 | 10.57 | 216 | 195552 | 99728 | 29656982 |
| Interstitial lung disease | 194.40 | 10.57 | 75 | 195693 | 60122 | 29696588 |
| Neutropenia | 188.71 | 10.57 | 345 | 195423 | 128195 | 29628515 |
| Hypotension | 175.78 | 10.57 | 2043 | 193725 | 198522 | 29558188 |
| Foetal exposure during pregnancy | 150.70 | 10.57 | 29 | 195739 | 36842 | 29719868 |
| Acute myocardial infarction | 141.69 | 10.57 | 703 | 195065 | 52236 | 29704474 |
| Dizziness | 140.57 | 10.57 | 1915 | 193853 | 192994 | 29563716 |
| Hepatic function abnormal | 134.18 | 10.57 | 53 | 195715 | 41892 | 29714818 |
| Pancreatitis | 119.38 | 10.57 | 514 | 195254 | 35976 | 29720734 |
| Coronary arterial stent insertion | 119.02 | 10.57 | 142 | 195626 | 4052 | 29752658 |
| Thrombocytopenia | 116.72 | 10.57 | 480 | 195288 | 136564 | 29620146 |
| Intestinal angioedema | 114.83 | 10.57 | 43 | 195725 | 129 | 29756581 |
| Drug hypersensitivity | 112.30 | 10.57 | 800 | 194968 | 67719 | 29688991 |
| Septic shock | 108.97 | 10.57 | 154 | 195614 | 63453 | 29693257 |
| C-reactive protein increased | 101.59 | 10.57 | 81 | 195687 | 43392 | 29713318 |
| Product use in unapproved indication | 99.19 | 10.57 | 208 | 195560 | 73485 | 29683225 |
| Coronary artery bypass | 88.75 | 10.57 | 137 | 195631 | 5025 | 29751685 |
| Pharyngeal oedema | 87.34 | 10.57 | 154 | 195614 | 6317 | 29750393 |
| Hepatocellular injury | 86.85 | 10.57 | 29 | 195739 | 25442 | 29731268 |
| Leukopenia | 86.58 | 10.57 | 146 | 195622 | 56013 | 29700697 |
| Cytomegalovirus infection | 86.05 | 10.57 | 24 | 195744 | 23650 | 29733060 |
| Cholestasis | 85.78 | 10.57 | 28 | 195740 | 24922 | 29731788 |
| Disseminated intravascular coagulation | 85.34 | 10.57 | 20 | 195748 | 22151 | 29734559 |
| Agranulocytosis | 84.05 | 10.57 | 20 | 195748 | 21922 | 29734788 |
| Dehydration | 81.70 | 10.57 | 1196 | 194572 | 122343 | 29634367 |
| Pneumonia | 75.80 | 10.57 | 1638 | 194130 | 332668 | 29424042 |
| Blood potassium increased | 74.95 | 10.57 | 255 | 195513 | 15958 | 29740752 |
| Anaphylactic reaction | 74.40 | 10.57 | 371 | 195397 | 27611 | 29729099 |
| Bone marrow failure | 74.08 | 10.57 | 52 | 195716 | 29733 | 29726977 |
| Hypotensive transfusion reaction | 74.06 | 10.57 | 20 | 195748 | 8 | 29756702 |
| Drug resistance | 72.08 | 10.57 | 21 | 195747 | 20112 | 29736598 |
| Rheumatoid arthritis | 68.32 | 10.57 | 102 | 195666 | 41095 | 29715615 |
| Lactic acidosis | 66.81 | 10.57 | 390 | 195378 | 30823 | 29725887 |
| Neutrophil count decreased | 66.70 | 10.57 | 109 | 195659 | 42345 | 29714365 |
| Altered state of consciousness | 65.64 | 10.57 | 24 | 195744 | 19895 | 29736815 |
| Bronchopulmonary aspergillosis | 64.31 | 10.57 | 4 | 195764 | 12280 | 29744430 |
| Pancytopenia | 61.55 | 10.57 | 316 | 195452 | 84736 | 29671974 |
| Hypovolaemia | 60.44 | 10.57 | 157 | 195611 | 8448 | 29748262 |
| Drug ineffective | 59.74 | 10.57 | 1732 | 194036 | 338655 | 29418055 |
| Product dose omission issue | 58.53 | 10.57 | 882 | 194886 | 90749 | 29665961 |
| Treatment failure | 58.34 | 10.57 | 85 | 195683 | 34594 | 29722116 |
| Epilepsy | 57.44 | 10.57 | 30 | 195738 | 20139 | 29736571 |
| Blood glucose increased | 57.35 | 10.57 | 635 | 195133 | 60895 | 29695815 |
| Cough | 55.40 | 10.57 | 1140 | 194628 | 124502 | 29632208 |
| Coma | 54.54 | 10.57 | 114 | 195654 | 40335 | 29716375 |
| Death | 54.45 | 10.57 | 1852 | 193916 | 355431 | 29401279 |
| Gamma-glutamyltransferase increased | 53.35 | 10.57 | 68 | 195700 | 29282 | 29727428 |
| Hypertension | 52.49 | 10.57 | 1098 | 194670 | 120256 | 29636454 |
| Sepsis | 51.94 | 10.57 | 660 | 195108 | 145735 | 29610975 |
| Chest pain | 51.11 | 10.57 | 1065 | 194703 | 116562 | 29640148 |
| Blood pressure inadequately controlled | 51.06 | 10.57 | 73 | 195695 | 2497 | 29754213 |
| Mental status changes | 49.05 | 10.57 | 412 | 195356 | 36667 | 29720043 |
| Toxic skin eruption | 48.69 | 10.57 | 7 | 195761 | 11008 | 29745702 |
| Blood lactate dehydrogenase increased | 48.60 | 10.57 | 38 | 195730 | 20563 | 29736147 |
| Sopor | 48.55 | 10.57 | 7 | 195761 | 10984 | 29745726 |
| Diabetic neuropathy | 48.07 | 10.57 | 90 | 195678 | 3869 | 29752841 |
| Malignant neoplasm progression | 47.13 | 10.57 | 278 | 195490 | 72009 | 29684701 |
| Oral allergy syndrome | 45.95 | 10.57 | 14 | 195754 | 16 | 29756694 |
| Condition aggravated | 45.81 | 10.57 | 630 | 195138 | 137236 | 29619474 |
| Product use issue | 45.77 | 10.57 | 151 | 195617 | 45865 | 29710845 |
| Pneumocystis jirovecii pneumonia | 45.12 | 10.57 | 28 | 195740 | 17092 | 29739618 |
| Syncope | 44.81 | 10.57 | 792 | 194976 | 84111 | 29672599 |
| Immune reconstitution inflammatory syndrome | 44.69 | 10.57 | 4 | 195764 | 9097 | 29747613 |
| Premature baby | 44.41 | 10.57 | 27 | 195741 | 16664 | 29740046 |
| Synovitis | 43.75 | 10.57 | 6 | 195762 | 9777 | 29746933 |
| Platelet count decreased | 43.62 | 10.57 | 463 | 195305 | 105666 | 29651044 |
| Seizure | 42.78 | 10.57 | 424 | 195344 | 98051 | 29658659 |
| Mucosal inflammation | 42.76 | 10.57 | 84 | 195684 | 30410 | 29726300 |
| Infection | 41.99 | 10.57 | 318 | 195450 | 77756 | 29678954 |
| Intentional self-injury | 41.80 | 10.57 | 18 | 195750 | 13514 | 29743196 |
| Lymphocyte count decreased | 41.45 | 10.57 | 38 | 195730 | 19017 | 29737693 |
| Alanine aminotransferase increased | 41.16 | 10.57 | 300 | 195468 | 73976 | 29682734 |
| Hyperthermia | 41.13 | 10.57 | 8 | 195760 | 10091 | 29746619 |
| Psoriasis | 40.66 | 10.57 | 441 | 195327 | 42065 | 29714645 |
| Lower respiratory tract infection | 40.65 | 10.57 | 70 | 195698 | 26644 | 29730066 |
| Multiple organ dysfunction syndrome | 40.41 | 10.57 | 246 | 195522 | 63241 | 29693469 |
| Liver disorder | 39.87 | 10.57 | 84 | 195684 | 29638 | 29727072 |
| Suspected suicide | 39.81 | 10.57 | 73 | 195695 | 3088 | 29753622 |
| Cardiac failure | 39.29 | 10.57 | 352 | 195416 | 83066 | 29673644 |
| Fatigue | 39.26 | 10.57 | 2512 | 193256 | 318161 | 29438549 |
| Wheezing | 38.42 | 10.57 | 339 | 195429 | 30599 | 29726111 |
| Renal tubular necrosis | 37.59 | 10.57 | 198 | 195570 | 15053 | 29741657 |
| Dysphagia | 37.44 | 10.57 | 549 | 195219 | 56149 | 29700561 |
| Drug interaction | 37.04 | 10.57 | 1007 | 194761 | 198561 | 29558149 |
| Lymphopenia | 36.86 | 10.57 | 20 | 195748 | 13143 | 29743567 |
| Renal injury | 36.64 | 10.57 | 163 | 195605 | 11566 | 29745144 |
| Hyperbilirubinaemia | 36.60 | 10.57 | 34 | 195734 | 16908 | 29739802 |
| Lung disorder | 36.56 | 10.57 | 96 | 195672 | 31373 | 29725337 |
| Infusion related reaction | 36.41 | 10.57 | 139 | 195629 | 40425 | 29716285 |
| Vascular graft | 36.02 | 10.57 | 46 | 195722 | 1409 | 29755301 |
| Depressed level of consciousness | 35.60 | 10.57 | 129 | 195639 | 38093 | 29718617 |
| Cardiac disorder | 35.03 | 10.57 | 407 | 195361 | 39486 | 29717224 |
| Electrocardiogram T wave peaked | 34.73 | 10.57 | 28 | 195740 | 486 | 29756224 |
| Exposure during pregnancy | 34.38 | 10.57 | 9 | 195759 | 9252 | 29747458 |
| Injury | 33.98 | 10.57 | 251 | 195517 | 21480 | 29735230 |
| Dysphonia | 33.96 | 10.57 | 227 | 195541 | 18805 | 29737905 |
| Ischaemic cardiomyopathy | 33.58 | 10.57 | 104 | 195664 | 6193 | 29750517 |
| Hepatitis | 32.73 | 10.57 | 60 | 195708 | 22296 | 29734414 |
| Pancreatitis acute | 32.65 | 10.57 | 283 | 195485 | 25412 | 29731298 |
| Aspergillus infection | 32.50 | 10.57 | 13 | 195755 | 10201 | 29746509 |
| Graft versus host disease | 32.16 | 10.57 | 13 | 195755 | 10137 | 29746573 |
| Haemophagocytic lymphohistiocytosis | 31.91 | 10.57 | 12 | 195756 | 9779 | 29746931 |
| Pathogen resistance | 31.56 | 10.57 | 8 | 195760 | 8402 | 29748308 |
| Drug reaction with eosinophilia and systemic symptoms | 31.52 | 10.57 | 89 | 195679 | 28399 | 29728311 |
| Bradycardia | 31.33 | 10.57 | 602 | 195166 | 64924 | 29691786 |
| Transient ischaemic attack | 31.22 | 10.57 | 276 | 195492 | 24924 | 29731786 |
| Tongue oedema | 31.05 | 10.57 | 61 | 195707 | 2719 | 29753991 |
| Aspartate aminotransferase increased | 30.57 | 10.57 | 266 | 195502 | 63156 | 29693554 |
| Drug dependence | 30.43 | 10.57 | 58 | 195710 | 21237 | 29735473 |
| Pneumonitis | 30.21 | 10.57 | 86 | 195682 | 27368 | 29729342 |
| International normalised ratio increased | 29.86 | 10.57 | 458 | 195310 | 47281 | 29709429 |
| Mouth swelling | 29.70 | 10.57 | 44 | 195724 | 1555 | 29755155 |
| Angina unstable | 29.10 | 10.57 | 158 | 195610 | 12152 | 29744558 |
| Thrombotic microangiopathy | 29.00 | 10.57 | 10 | 195758 | 8600 | 29748110 |
| Feeling abnormal | 28.71 | 10.57 | 526 | 195242 | 56230 | 29700480 |
| Intentional product use issue | 28.30 | 10.57 | 132 | 195636 | 36308 | 29720402 |
| Device interaction | 28.26 | 10.57 | 23 | 195745 | 405 | 29756305 |
| Drooling | 27.78 | 10.57 | 61 | 195707 | 2944 | 29753766 |
| Eosinophilia | 27.77 | 10.57 | 65 | 195703 | 22095 | 29734615 |
| Anaemia | 27.75 | 10.57 | 1095 | 194673 | 206897 | 29549813 |
| Fear | 27.69 | 10.57 | 142 | 195626 | 10683 | 29746027 |
| Transaminases increased | 27.68 | 10.57 | 71 | 195697 | 23386 | 29733324 |
| Pelvic mass | 27.47 | 10.57 | 15 | 195753 | 129 | 29756581 |
| Asthenia | 27.46 | 10.57 | 1736 | 194032 | 219554 | 29537156 |
| Muscle spasms | 27.45 | 10.57 | 585 | 195183 | 64253 | 29692457 |
| Venoocclusive liver disease | 27.44 | 10.57 | 5 | 195763 | 6608 | 29750102 |
| Pulmonary renal syndrome | 27.44 | 10.57 | 16 | 195752 | 158 | 29756552 |
| Blood glucose decreased | 27.21 | 10.57 | 162 | 195606 | 12891 | 29743819 |
| Infective pulmonary exacerbation of cystic fibrosis | 27.12 | 10.57 | 11 | 195757 | 8561 | 29748149 |
| Pneumonia aspiration | 26.95 | 10.57 | 141 | 195627 | 37639 | 29719071 |
| Status epilepticus | 26.65 | 10.57 | 20 | 195748 | 11052 | 29745658 |
| Blood pressure increased | 26.40 | 10.57 | 636 | 195132 | 71292 | 29685418 |
| Neuroleptic malignant syndrome | 26.38 | 10.57 | 41 | 195727 | 16254 | 29740456 |
| Asthma | 26.37 | 10.57 | 134 | 195634 | 36040 | 29720670 |
| Hypophagia | 26.25 | 10.57 | 241 | 195527 | 21995 | 29734715 |
| Encephalopathy | 26.00 | 10.57 | 115 | 195653 | 32090 | 29724620 |
| Dysgeusia | 25.92 | 10.57 | 262 | 195506 | 24539 | 29732171 |
| Substance abuse | 25.84 | 10.57 | 7 | 195761 | 7033 | 29749677 |
| Transplant rejection | 25.76 | 10.57 | 14 | 195754 | 9192 | 29747518 |
| Erythema | 25.66 | 10.57 | 354 | 195414 | 77097 | 29679613 |
| Ageusia | 25.43 | 10.57 | 121 | 195647 | 8832 | 29747878 |
| Drug-induced liver injury | 25.40 | 10.57 | 64 | 195704 | 21210 | 29735500 |
| Blood alkaline phosphatase increased | 25.08 | 10.57 | 113 | 195655 | 31374 | 29725336 |
| Drug intolerance | 25.04 | 10.57 | 183 | 195585 | 45108 | 29711602 |
| Blood creatinine increased | 24.77 | 10.57 | 777 | 194991 | 90598 | 29666112 |
| Mydriasis | 24.74 | 10.57 | 5 | 195763 | 6138 | 29750572 |
| Pancreatitis necrotising | 24.69 | 10.57 | 51 | 195717 | 2358 | 29754352 |
| Nodular rash | 24.59 | 10.57 | 11 | 195757 | 58 | 29756652 |
| Allergic cough | 24.53 | 10.57 | 9 | 195759 | 25 | 29756685 |
| Anhedonia | 24.42 | 10.57 | 114 | 195654 | 8255 | 29748455 |
| Oropharyngeal swelling | 24.31 | 10.57 | 22 | 195746 | 450 | 29756260 |
| Hyperlipidaemia | 24.29 | 10.57 | 165 | 195603 | 13742 | 29742968 |
| Myocardial ischaemia | 24.28 | 10.57 | 195 | 195573 | 17122 | 29739588 |
| Vision blurred | 24.19 | 10.57 | 396 | 195372 | 41420 | 29715290 |
| Emotional distress | 24.03 | 10.57 | 181 | 195587 | 15584 | 29741126 |
| Paraesthesia | 23.92 | 10.57 | 493 | 195275 | 53834 | 29702876 |
| Toxic epidermal necrolysis | 23.81 | 10.57 | 51 | 195717 | 17889 | 29738821 |
| Peritonitis | 23.49 | 10.57 | 67 | 195701 | 21308 | 29735402 |
| Blood urea increased | 23.18 | 10.57 | 310 | 195458 | 31071 | 29725639 |
| Acute hepatic failure | 22.98 | 10.57 | 26 | 195742 | 11801 | 29744909 |
| Haematotoxicity | 22.90 | 10.57 | 6 | 195762 | 6164 | 29750546 |
| Hypoglycaemia | 22.56 | 10.57 | 463 | 195305 | 50518 | 29706192 |
| Hepatocellular carcinoma | 22.32 | 10.57 | 18 | 195750 | 9592 | 29747118 |
| Epstein-Barr virus infection | 22.23 | 10.57 | 8 | 195760 | 6698 | 29750012 |
| Myelosuppression | 22.20 | 10.57 | 10 | 195758 | 7312 | 29749398 |
| Ulnar nerve palsy | 22.11 | 10.57 | 7 | 195761 | 10 | 29756700 |
| Orthostatic hypotension | 22.11 | 10.57 | 247 | 195521 | 23732 | 29732978 |
| Post transplant lymphoproliferative disorder | 22.04 | 10.57 | 4 | 195764 | 5302 | 29751408 |
| Product quality issue | 21.92 | 10.57 | 203 | 195565 | 18571 | 29738139 |
| Jaundice | 21.65 | 10.57 | 124 | 195644 | 32362 | 29724348 |
| Hepatic failure | 21.60 | 10.57 | 132 | 195636 | 33911 | 29722799 |
| Tuberculosis | 21.58 | 10.57 | 13 | 195755 | 8064 | 29748646 |
| Cystitis haemorrhagic | 21.26 | 10.57 | 3 | 195765 | 4784 | 29751926 |
| Blood bilirubin increased | 21.24 | 10.57 | 146 | 195622 | 36490 | 29720220 |
| Circulatory collapse | 21.02 | 10.57 | 65 | 195703 | 20149 | 29736561 |
| Similar reaction on previous exposure to drug | 20.83 | 10.57 | 9 | 195759 | 43 | 29756667 |
| Progressive multifocal leukoencephalopathy | 20.79 | 10.57 | 17 | 195751 | 8996 | 29747714 |
| Product complaint | 20.70 | 10.57 | 84 | 195684 | 5722 | 29750988 |
| Anal abscess | 20.68 | 10.57 | 4 | 195764 | 5065 | 29751645 |
| Posterior reversible encephalopathy syndrome | 20.61 | 10.57 | 16 | 195752 | 8691 | 29748019 |
| Glycosylated haemoglobin increased | 20.57 | 10.57 | 119 | 195649 | 9372 | 29747338 |
| Enterocolitis | 20.49 | 10.57 | 9 | 195759 | 6678 | 29750032 |
| Arteriosclerosis coronary artery | 20.36 | 10.57 | 134 | 195634 | 11042 | 29745668 |
| White blood cell count decreased | 20.16 | 10.57 | 407 | 195361 | 83540 | 29673170 |
| Urine oxalate increased | 20.04 | 10.57 | 7 | 195761 | 16 | 29756694 |
| Eosinophil count increased | 20.00 | 10.57 | 12 | 195756 | 7461 | 29749249 |
| Hepatic encephalopathy | 19.98 | 10.57 | 39 | 195729 | 14153 | 29742557 |
| Chronic kidney disease | 19.95 | 10.57 | 353 | 195415 | 37485 | 29719225 |
| Hypertensive emergency | 19.83 | 10.57 | 26 | 195742 | 818 | 29755892 |
| Schizophrenia | 19.73 | 10.57 | 18 | 195750 | 9030 | 29747680 |
| Device related infection | 19.69 | 10.57 | 52 | 195716 | 16963 | 29739747 |
| Neurotoxicity | 19.64 | 10.57 | 35 | 195733 | 13147 | 29743563 |
| Vitreous floaters | 19.59 | 10.57 | 56 | 195712 | 3188 | 29753522 |
| Labelled drug-drug interaction medication error | 19.58 | 10.57 | 24 | 195744 | 10514 | 29746196 |
| Myalgia | 19.49 | 10.57 | 647 | 195121 | 76020 | 29680690 |
| Delirium | 19.31 | 10.57 | 171 | 195597 | 40460 | 29716250 |
| Plasmapheresis | 19.30 | 10.57 | 17 | 195751 | 335 | 29756375 |
| Blood urea abnormal | 19.28 | 10.57 | 23 | 195745 | 656 | 29756054 |
| Encephalitis | 19.19 | 10.57 | 9 | 195759 | 6427 | 29750283 |
| Aggression | 19.04 | 10.57 | 152 | 195616 | 36755 | 29719955 |
| Increased tendency to bruise | 18.96 | 10.57 | 59 | 195709 | 3522 | 29753188 |
| Renal artery stenosis | 18.93 | 10.57 | 39 | 195729 | 1800 | 29754910 |
| Cholangitis | 18.90 | 10.57 | 14 | 195754 | 7788 | 29748922 |
| Laryngeal oedema | 18.86 | 10.57 | 56 | 195712 | 3258 | 29753452 |
| Acute respiratory distress syndrome | 18.83 | 10.57 | 84 | 195684 | 23388 | 29733322 |
| Tachycardia | 18.77 | 10.57 | 354 | 195414 | 73385 | 29683325 |
| Nausea | 18.70 | 10.57 | 2215 | 193553 | 294742 | 29461968 |
| Rash maculo-papular | 18.61 | 10.57 | 94 | 195674 | 25324 | 29731386 |
| No reaction on previous exposure to drug | 18.61 | 10.57 | 10 | 195758 | 83 | 29756627 |
| Product coating issue | 18.45 | 10.57 | 7 | 195761 | 22 | 29756688 |
| Oxygen saturation decreased | 18.44 | 10.57 | 188 | 195580 | 43252 | 29713458 |
| Colitis ulcerative | 18.36 | 10.57 | 42 | 195726 | 14392 | 29742318 |
| Pseudomonas infection | 18.31 | 10.57 | 25 | 195743 | 10457 | 29746253 |
| Diabetic foot infection | 18.25 | 10.57 | 23 | 195745 | 695 | 29756015 |
| Renal impairment neonatal | 18.22 | 10.57 | 7 | 195761 | 23 | 29756687 |
| Renal tubular acidosis | 18.00 | 10.57 | 38 | 195730 | 1784 | 29754926 |
| Hepatitis cholestatic | 17.97 | 10.57 | 15 | 195753 | 7857 | 29748853 |
| Acute myeloid leukaemia | 17.96 | 10.57 | 59 | 195709 | 17947 | 29738763 |
| Aplastic anaemia | 17.79 | 10.57 | 7 | 195761 | 5549 | 29751161 |
| Myelodysplastic syndrome | 17.73 | 10.57 | 63 | 195705 | 18715 | 29737995 |
| Hepatotoxicity | 17.72 | 10.57 | 60 | 195708 | 18085 | 29738625 |
| Oedema genital | 17.53 | 10.57 | 16 | 195752 | 331 | 29756379 |
| Kidney transplant rejection | 17.52 | 10.57 | 14 | 195754 | 7495 | 29749215 |
| Pharyngeal swelling | 17.52 | 10.57 | 31 | 195737 | 1275 | 29755435 |
| Product substitution issue | 17.49 | 10.57 | 119 | 195649 | 9916 | 29746794 |
| Pulmonary arterial hypertension | 17.47 | 10.57 | 21 | 195747 | 9280 | 29747430 |
| Osteonecrosis | 17.42 | 10.57 | 51 | 195717 | 16084 | 29740626 |
| Hypoaesthesia | 17.39 | 10.57 | 471 | 195297 | 53759 | 29702951 |
| Swelling | 17.35 | 10.57 | 331 | 195437 | 35644 | 29721066 |
| Chronic graft versus host disease | 17.34 | 10.57 | 3 | 195765 | 4116 | 29752594 |
| Prostate cancer recurrent | 17.34 | 10.57 | 23 | 195745 | 732 | 29755978 |
| Eye swelling | 17.26 | 10.57 | 109 | 195659 | 8855 | 29747855 |
| Osteonecrosis of jaw | 17.22 | 10.57 | 63 | 195705 | 18555 | 29738155 |
| Cachexia | 17.16 | 10.57 | 11 | 195757 | 6600 | 29750110 |
| Rash pruritic | 17.09 | 10.57 | 224 | 195544 | 22348 | 29734362 |
| Lip oedema | 16.94 | 10.57 | 42 | 195726 | 2195 | 29754515 |
| Generalised tonic-clonic seizure | 16.90 | 10.57 | 68 | 195700 | 19483 | 29737227 |
| Tumour lysis syndrome | 16.79 | 10.57 | 37 | 195731 | 12848 | 29743862 |
| Carcinoid tumour of the gastrointestinal tract | 16.78 | 10.57 | 8 | 195760 | 50 | 29756660 |
| Acquired acrodermatitis enteropathica | 16.75 | 10.57 | 5 | 195763 | 5 | 29756705 |
| Blood cholesterol increased | 16.65 | 10.57 | 177 | 195591 | 16793 | 29739917 |
| Electrocardiogram change | 16.65 | 10.57 | 21 | 195747 | 635 | 29756075 |
| Toxicity to various agents | 16.62 | 10.57 | 968 | 194800 | 176215 | 29580495 |
| Cardio-respiratory arrest | 16.54 | 10.57 | 269 | 195499 | 57037 | 29699673 |
| Drug level increased | 16.40 | 10.57 | 63 | 195705 | 18291 | 29738419 |
| Spur cell anaemia | 16.39 | 10.57 | 8 | 195760 | 53 | 29756657 |
| Hypoaesthesia oral | 16.36 | 10.57 | 56 | 195712 | 3514 | 29753196 |
| Cerebral infarction | 16.35 | 10.57 | 103 | 195665 | 26270 | 29730440 |
| Therapy cessation | 16.34 | 10.57 | 161 | 195607 | 14976 | 29741734 |
| Miosis | 16.33 | 10.57 | 16 | 195752 | 7760 | 29748950 |
| Renal failure | 16.18 | 10.57 | 1013 | 194755 | 127953 | 29628757 |
| Adenovirus infection | 16.13 | 10.57 | 4 | 195764 | 4264 | 29752446 |
| Accelerated hypertension | 16.11 | 10.57 | 13 | 195755 | 226 | 29756484 |
| Second primary malignancy | 15.93 | 10.57 | 11 | 195757 | 6345 | 29750365 |
| Maternal exposure during pregnancy | 15.91 | 10.57 | 3 | 195765 | 3868 | 29752842 |
| Dizziness postural | 15.90 | 10.57 | 75 | 195693 | 5455 | 29751255 |
| Colitis | 15.87 | 10.57 | 127 | 195641 | 30693 | 29726017 |
| Hyperuricaemia | 15.78 | 10.57 | 15 | 195753 | 7379 | 29749331 |
| Pulmonary tuberculosis | 15.75 | 10.57 | 6 | 195762 | 4851 | 29751859 |
| Arteriosclerosis | 15.74 | 10.57 | 123 | 195645 | 10710 | 29746000 |
| Hepatitis acute | 15.55 | 10.57 | 14 | 195754 | 7069 | 29749641 |
| Pleural effusion | 15.50 | 10.57 | 367 | 195401 | 73699 | 29683011 |
| Neutrophil count increased | 15.42 | 10.57 | 50 | 195718 | 15273 | 29741437 |
| Polyneuropathy | 15.37 | 10.57 | 34 | 195734 | 11789 | 29744921 |
| Conjunctival scar | 15.35 | 10.57 | 8 | 195760 | 62 | 29756648 |
| Gout | 15.35 | 10.57 | 177 | 195591 | 17138 | 29739572 |
| Burning sensation | 15.32 | 10.57 | 170 | 195598 | 16304 | 29740406 |
| Electrocardiogram QT prolonged | 15.25 | 10.57 | 155 | 195613 | 35680 | 29721030 |
| Complications of transplanted kidney | 15.20 | 10.57 | 4 | 195764 | 4097 | 29752613 |
| Respiratory tract oedema | 15.17 | 10.57 | 16 | 195752 | 397 | 29756313 |
| Psychomotor hyperactivity | 15.00 | 10.57 | 19 | 195749 | 8205 | 29748505 |
| Lymphoma | 14.96 | 10.57 | 27 | 195741 | 10094 | 29746616 |
| Oedema mouth | 14.94 | 10.57 | 29 | 195739 | 1281 | 29755429 |
| Hypotonia | 14.94 | 10.57 | 14 | 195754 | 6934 | 29749776 |
| Inflammation | 14.72 | 10.57 | 84 | 195684 | 21942 | 29734768 |
| Benign gastrointestinal neoplasm | 14.57 | 10.57 | 10 | 195758 | 134 | 29756576 |
| Enlarged uvula | 14.51 | 10.57 | 10 | 195758 | 135 | 29756575 |
| Epiglottic oedema | 14.50 | 10.57 | 11 | 195757 | 174 | 29756536 |
| Stridor | 14.47 | 10.57 | 40 | 195728 | 2234 | 29754476 |
| Stent placement | 14.45 | 10.57 | 64 | 195704 | 4532 | 29752178 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 14.34 | 10.57 | 19 | 195749 | 604 | 29756106 |
| Blood electrolytes abnormal | 14.26 | 10.57 | 23 | 195745 | 876 | 29755834 |
| Atrial fibrillation | 14.25 | 10.57 | 853 | 194915 | 107271 | 29649439 |
| Cytomegalovirus viraemia | 14.24 | 10.57 | 10 | 195758 | 5719 | 29750991 |
| Cytokine release syndrome | 14.24 | 10.57 | 27 | 195741 | 9906 | 29746804 |
| Coronary artery occlusion | 14.23 | 10.57 | 123 | 195645 | 11034 | 29745676 |
| Blood glucose abnormal | 14.16 | 10.57 | 70 | 195698 | 5189 | 29751521 |
| Carcinoid tumour of the stomach | 14.14 | 10.57 | 7 | 195761 | 48 | 29756662 |
| Essential hypertension | 14.12 | 10.57 | 42 | 195726 | 2446 | 29754264 |
| Stomatitis | 13.97 | 10.57 | 166 | 195602 | 37113 | 29719597 |
| Lymphomatoid papulosis | 13.93 | 10.57 | 11 | 195757 | 185 | 29756525 |
| Neutropenic sepsis | 13.87 | 10.57 | 34 | 195734 | 11375 | 29745335 |
| Pollakiuria | 13.74 | 10.57 | 170 | 195598 | 16736 | 29739974 |
| Facial asymmetry | 13.59 | 10.57 | 13 | 195755 | 286 | 29756424 |
| Candida infection | 13.55 | 10.57 | 53 | 195715 | 15309 | 29741401 |
| Nocardiosis | 13.53 | 10.57 | 3 | 195765 | 3452 | 29753258 |
| Hypocalcaemia | 13.50 | 10.57 | 83 | 195685 | 21293 | 29735417 |
| Oral candidiasis | 13.45 | 10.57 | 33 | 195735 | 11038 | 29745672 |
| Cognitive disorder | 13.44 | 10.57 | 95 | 195673 | 23595 | 29733115 |
| Diabetic retinopathy | 13.41 | 10.57 | 33 | 195735 | 1717 | 29754993 |
| Azotaemia | 13.40 | 10.57 | 66 | 195702 | 4886 | 29751824 |
| Speech disorder | 13.39 | 10.57 | 230 | 195538 | 24282 | 29732428 |
| Glomerular filtration rate abnormal | 13.38 | 10.57 | 17 | 195751 | 518 | 29756192 |
| Psychotic disorder | 13.35 | 10.57 | 84 | 195684 | 21431 | 29735279 |
| Drug eruption | 13.30 | 10.57 | 64 | 195704 | 17462 | 29739248 |
| Pemphigus | 13.28 | 10.57 | 27 | 195741 | 1234 | 29755476 |
| Sinus node dysfunction | 13.23 | 10.57 | 55 | 195713 | 3788 | 29752922 |
| Tympanic membrane disorder | 13.21 | 10.57 | 6 | 195762 | 33 | 29756677 |
| Serotonin syndrome | 13.19 | 10.57 | 66 | 195702 | 17825 | 29738885 |
| Unevaluable event | 13.19 | 10.57 | 286 | 195482 | 31499 | 29725211 |
| Cytopenia | 13.15 | 10.57 | 21 | 195747 | 8235 | 29748475 |
| Alcoholic ketoacidosis | 13.11 | 10.57 | 5 | 195763 | 16 | 29756694 |
| Throat tightness | 12.96 | 10.57 | 86 | 195682 | 7106 | 29749604 |
| Plasma cell myeloma | 12.89 | 10.57 | 259 | 195509 | 53203 | 29703507 |
| Hypergastrinaemia | 12.78 | 10.57 | 6 | 195762 | 36 | 29756674 |
| Food allergy | 12.76 | 10.57 | 22 | 195746 | 886 | 29755824 |
| Respiratory tract infection | 12.74 | 10.57 | 55 | 195713 | 15451 | 29741259 |
| Cataract nuclear | 12.71 | 10.57 | 16 | 195752 | 483 | 29756227 |
| Application site infection | 12.65 | 10.57 | 6 | 195762 | 37 | 29756673 |
| Dystonia | 12.62 | 10.57 | 28 | 195740 | 9699 | 29747011 |
| Haemorrhage intracranial | 12.59 | 10.57 | 152 | 195616 | 14880 | 29741830 |
| Akathisia | 12.57 | 10.57 | 12 | 195756 | 5892 | 29750818 |
| Productive cough | 12.56 | 10.57 | 130 | 195638 | 29823 | 29726887 |
| Hypertriglyceridaemia | 12.52 | 10.57 | 21 | 195747 | 8077 | 29748633 |
| Bronchospasm | 12.42 | 10.57 | 31 | 195737 | 10307 | 29746403 |
| Dermatitis bullous | 12.32 | 10.57 | 13 | 195755 | 6091 | 29750619 |
| Paraesthesia oral | 12.29 | 10.57 | 52 | 195716 | 3609 | 29753101 |
| Dilatation atrial | 12.24 | 10.57 | 36 | 195732 | 2083 | 29754627 |
| Skin tightness | 12.20 | 10.57 | 35 | 195733 | 1997 | 29754713 |
| Pneumopericardium | 12.19 | 10.57 | 7 | 195761 | 67 | 29756643 |
| Hypokalaemia | 12.14 | 10.57 | 243 | 195525 | 49949 | 29706761 |
| Small for dates baby | 12.14 | 10.57 | 3 | 195765 | 3205 | 29753505 |
| Lipoedema | 12.11 | 10.57 | 3 | 195765 | 0 | 29756710 |
| Endotracheal intubation complication | 12.09 | 10.57 | 13 | 195755 | 330 | 29756380 |
| Procedural hypotension | 12.07 | 10.57 | 23 | 195745 | 1002 | 29755708 |
| Non-cardiac chest pain | 12.05 | 10.57 | 56 | 195712 | 4048 | 29752662 |
| Hypoalbuminaemia | 12.01 | 10.57 | 35 | 195733 | 11057 | 29745653 |
| Hyperammonaemia | 12.01 | 10.57 | 11 | 195757 | 5509 | 29751201 |
| Hypogammaglobulinaemia | 12.00 | 10.57 | 10 | 195758 | 5242 | 29751468 |
| Immunosuppressant drug level increased | 11.97 | 10.57 | 8 | 195760 | 4694 | 29752016 |
| Type 2 diabetes mellitus | 11.96 | 10.57 | 139 | 195629 | 13483 | 29743227 |
| Pain | 11.95 | 10.57 | 1296 | 194472 | 171345 | 29585365 |
| Gastric cancer | 11.84 | 10.57 | 9 | 195759 | 4941 | 29751769 |
| Diverticulum | 11.83 | 10.57 | 80 | 195688 | 6653 | 29750057 |
| Bronchiectasis | 11.77 | 10.57 | 10 | 195758 | 5194 | 29751516 |
| Myxoedema coma | 11.77 | 10.57 | 12 | 195756 | 286 | 29756424 |
| Gallbladder oedema | 11.74 | 10.57 | 10 | 195758 | 188 | 29756522 |
| Atrial septal defect | 11.69 | 10.57 | 16 | 195752 | 6685 | 29750025 |
| Cardiovascular disorder | 11.59 | 10.57 | 116 | 195652 | 10836 | 29745874 |
| Diffuse large B-cell lymphoma | 11.52 | 10.57 | 21 | 195747 | 7820 | 29748890 |
| Stress | 11.46 | 10.57 | 191 | 195577 | 20044 | 29736666 |
| Subileus | 11.46 | 10.57 | 3 | 195765 | 3084 | 29753626 |
| Penile swelling | 11.45 | 10.57 | 20 | 195748 | 814 | 29755896 |
| Brain oedema | 11.44 | 10.57 | 42 | 195726 | 12356 | 29744354 |
| Therapeutic product effect incomplete | 11.43 | 10.57 | 154 | 195614 | 33680 | 29723030 |
| Intestinal obstruction | 11.41 | 10.57 | 76 | 195692 | 19136 | 29737574 |
| Oligohydramnios | 11.37 | 10.57 | 12 | 195756 | 298 | 29756412 |
| Metabolic acidosis | 11.34 | 10.57 | 323 | 195445 | 37138 | 29719572 |
| Osteoporosis | 11.29 | 10.57 | 34 | 195734 | 10629 | 29746081 |
| Maternal drugs affecting foetus | 11.24 | 10.57 | 7 | 195761 | 4266 | 29752444 |
| Enterococcal infection | 11.23 | 10.57 | 23 | 195745 | 8201 | 29748509 |
| Pelvic neoplasm | 11.20 | 10.57 | 4 | 195764 | 10 | 29756700 |
| Sedation | 11.18 | 10.57 | 62 | 195706 | 16311 | 29740399 |
| Organising pneumonia | 11.18 | 10.57 | 10 | 195758 | 5064 | 29751646 |
| Weaning failure | 11.17 | 10.57 | 11 | 195757 | 251 | 29756459 |
| Renal mass | 11.14 | 10.57 | 28 | 195740 | 1476 | 29755234 |
| Hypoventilation | 11.10 | 10.57 | 3 | 195765 | 3020 | 29753690 |
| Vomiting projectile | 11.00 | 10.57 | 17 | 195751 | 624 | 29756086 |
| Pericarditis | 10.98 | 10.57 | 25 | 195743 | 8581 | 29748129 |
| Anaesthesia | 10.95 | 10.57 | 6 | 195762 | 52 | 29756658 |
| Haemolysis | 10.95 | 10.57 | 19 | 195749 | 7212 | 29749498 |
| Raynaud's phenomenon | 10.93 | 10.57 | 12 | 195756 | 312 | 29756398 |
| Malaise | 10.91 | 10.57 | 941 | 194827 | 166021 | 29590689 |
| Somnolence | 10.88 | 10.57 | 519 | 195249 | 96244 | 29660466 |
| Graft versus host disease in skin | 10.87 | 10.57 | 4 | 195764 | 3303 | 29753407 |
| Acute coronary syndrome | 10.83 | 10.57 | 136 | 195632 | 13437 | 29743273 |
| Occult blood positive | 10.81 | 10.57 | 51 | 195717 | 3709 | 29753001 |
| Terminal state | 10.81 | 10.57 | 5 | 195763 | 3599 | 29753111 |
| Prostatic specific antigen increased | 10.77 | 10.57 | 123 | 195645 | 11881 | 29744829 |
| Haemoglobin decreased | 10.74 | 10.57 | 623 | 195145 | 113475 | 29643235 |
| Albumin urine present | 10.73 | 10.57 | 13 | 195755 | 377 | 29756333 |
| Autoimmune disorder | 10.73 | 10.57 | 28 | 195740 | 1511 | 29755199 |
| Endometriosis male | 10.68 | 10.57 | 4 | 195764 | 12 | 29756698 |
| Anaphylactic shock | 10.68 | 10.57 | 51 | 195717 | 13942 | 29742768 |
| Clostridium difficile infection | 10.65 | 10.57 | 60 | 195708 | 15723 | 29740987 |
| Blood sodium decreased | 10.64 | 10.57 | 154 | 195614 | 15702 | 29741008 |
| Liver abscess | 10.63 | 10.57 | 4 | 195764 | 3258 | 29753452 |
| Diabetic ketoacidosis | 10.62 | 10.57 | 155 | 195613 | 15831 | 29740879 |
| Diverticulum intestinal haemorrhagic | 10.62 | 10.57 | 34 | 195734 | 2061 | 29754649 |
| Back pain | 10.59 | 10.57 | 793 | 194975 | 101803 | 29654907 |
| Lipodystrophy acquired | 10.58 | 10.57 | 5 | 195763 | 3555 | 29753155 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C09AA03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
| ATC | C09BA03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics |
| ATC | C09BB03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
| ATC | C10BX07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
| MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002316 | Cardiotonic Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:35674 | antihypertensive |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Myocardial infarction | indication | 22298006 | DOID:5844 |
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Chronic heart failure | indication | 48447003 | |
| Superficial Ocular Infection | indication | ||
| Diabetic retinopathy | off-label use | 4855003 | DOID:8947 |
| Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
| Blepharoconjunctivitis | off-label use | 68659002 | DOID:2456 |
| Dacryocystitis | off-label use | 85777005 | DOID:9938 |
| Corneal ulcer | off-label use | 91514001 | DOID:8463 |
| Diabetic renal disease | off-label use | 127013003 | |
| Bacterial conjunctivitis | off-label use | 128350005 | DOID:9700 |
| Acute scleroderma renal crisis | off-label use | 236503001 | |
| Meibomianitis | off-label use | 309779001 | |
| Infective blepharitis | off-label use | 312219000 | |
| Bacterial keratitis | off-label use | 314557000 | |
| Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
| Nondiabetic Proteinuric Nephropathy | off-label use | ||
| Migraine Prevention | off-label use | ||
| Anuria | contraindication | 2472002 | DOID:2983 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Hyperkalemia | contraindication | 14140009 | |
| Jaundice | contraindication | 18165001 | |
| Secondary angle-closure glaucoma | contraindication | 21571006 | |
| Hypovolemia | contraindication | 28560003 | |
| Acute cerebrovascular insufficiency | contraindication | 29322000 | |
| Dehydration | contraindication | 34095006 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Immunosuppression | contraindication | 38013005 | |
| Angioedema | contraindication | 41291007 | DOID:1558 |
| Hypokalemia | contraindication | 43339004 | |
| Low blood pressure | contraindication | 45007003 | |
| Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Sympathectomy | contraindication | 57071006 | |
| Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
| Hypochloremic alkalosis | contraindication | 70134007 | |
| Hepatic coma | contraindication | 72836002 | DOID:12550 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Hypomagnesemia | contraindication | 190855004 | |
| Acute hepatic failure | contraindication | 197270009 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Disorder of electrolytes | contraindication | 237840007 | |
| Neonatal hyperbilirubinemia | contraindication | 281610001 | |
| Pregnancy, function | contraindication | 289908002 | |
| Renal artery stenosis | contraindication | 302233006 | |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Bone marrow depression | contraindication | 307762000 | |
| Azotemia | contraindication | 445009001 | |
| Hemodialysis with High-Flux Membrane | contraindication | ||
| Intestinal Angioedema | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.18 | acidic |
| pKa2 | 3.18 | acidic |
| pKa3 | 11.0 | Basic |
| pKa4 | 6.95 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 8.92 | WOMBAT-PK | CHEMBL | |||
| Angiotensin-converting enzyme | Enzyme | Ki | 7.29 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019380 | VUID |
| N0000147537 | NUI |
| D00362 | KEGG_DRUG |
| 83915-83-7 | SECONDARY_CAS_RN |
| 4019380 | VANDF |
| C0065374 | UMLSCUI |
| CHEBI:6503 | CHEBI |
| LPR | PDB_CHEM_ID |
| CHEMBL419213 | ChEMBL_ID |
| CHEMBL1237 | ChEMBL_ID |
| CHEMBL1729579 | ChEMBL_ID |
| D017706 | MESH_DESCRIPTOR_UI |
| DB00722 | DRUGBANK_ID |
| 6360 | IUPHAR_LIGAND_ID |
| E7199S1YWR | UNII |
| 5362119 | PUBCHEM_CID |
| 29046 | RXNORM |
| 31907 | MMSL |
| 44066 | MMSL |
| 4985 | MMSL |
| d00732 | MMSL |
| 000658 | NDDF |
| 108575001 | SNOMEDCT_US |
| 341000220102 | SNOMEDCT_US |
| 386873009 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| PRINIVIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0006-0019 | TABLET | 5 mg | ORAL | NDA | 27 sections |
| PRINIVIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0006-0106 | TABLET | 10 mg | ORAL | NDA | 27 sections |
| PRINIVIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0006-0207 | TABLET | 20 mg | ORAL | NDA | 27 sections |
| Lisinopril with Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-1262 | TABLET | 10 mg | ORAL | ANDA | 24 sections |
| Lisinopril with Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-1263 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
| Lisinopril with Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-1264 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
| Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9713 | TABLET | 20 mg | ORAL | ANDA | 26 sections |
| Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9714 | TABLET | 10 mg | ORAL | ANDA | 26 sections |
| Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9715 | TABLET | 5 mg | ORAL | ANDA | 26 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0025 | TABLET | 2.50 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0101 | TABLET | 10 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0102 | TABLET | 20 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0103 | TABLET | 30 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0104 | TABLET | 40 mg | ORAL | ANDA | 25 sections |
| Lisinopril and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0152 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
| Lisinopril and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0173 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0602 | TABLET | 2.50 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0605 | TABLET | 5 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0610 | TABLET | 10 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0620 | TABLET | 20 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0630 | TABLET | 30 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0640 | TABLET | 40 mg | ORAL | ANDA | 25 sections |
| lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-5400 | TABLET | 5 mg | ORAL | ANDA | 25 sections |
| Lisinopril and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-7100 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-7674 | TABLET | 5 mg | ORAL | ANDA | 21 sections |
| Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0405 | TABLET | 2.50 mg | ORAL | ANDA | 26 sections |
| Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0406 | TABLET | 5 mg | ORAL | ANDA | 26 sections |
| Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0407 | TABLET | 10 mg | ORAL | ANDA | 26 sections |
| Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0408 | TABLET | 20 mg | ORAL | ANDA | 26 sections |
| Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0409 | TABLET | 40 mg | ORAL | ANDA | 26 sections |