lisinopril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 1587 76547-98-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lisinopril
  • linopril
  • nanopril
  • lisinopril hydrate
  • lisinopril dihydrate
  • anhydrous lisinopril
One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.
  • Molecular weight: 405.50
  • Formula: C21H31N3O5
  • CLOGP: -1.82
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 132.96
  • ALOGS: -3.27
  • ROTB: 12

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 97 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 94 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.41 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.89 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 42 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1987 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 1558.30 9.74 1339 207343 38003 46439377
Cardiac failure congestive 550.42 9.74 1246 207436 90504 46386876
Intestinal angioedema 487.54 9.74 157 208525 432 46476948
Myocardial infarction 471.89 9.74 1219 207463 96309 46381071
Swollen tongue 314.16 9.74 509 208173 28723 46448657
Cerebrovascular accident 284.13 9.74 1045 207637 99994 46377386
Rheumatoid arthritis 234.20 9.74 449 208233 239766 46237614
Off label use 229.42 9.74 898 207784 378943 46098437
Coronary artery disease 223.20 9.74 477 208205 33275 46444105
Exposure during pregnancy 220.19 9.74 104 208578 108108 46369272
Maternal exposure during pregnancy 215.77 9.74 94 208588 102455 46374925
Acute kidney injury 215.29 9.74 1794 206888 234061 46243319
Drug ineffective 196.69 9.74 2012 206670 675826 45801554
Pyrexia 176.33 9.74 881 207801 347921 46129459
Lip swelling 173.81 9.74 364 208318 25031 46452349
Contraindicated product administered 160.83 9.74 78 208604 79869 46397511
Infusion related reaction 149.60 9.74 139 208543 101069 46376311
Drug abuse 141.69 9.74 53 208629 63355 46414025
Drug intolerance 141.28 9.74 277 208405 146772 46330608
Synovitis 134.89 9.74 52 208630 61023 46416357
Acute myocardial infarction 133.07 9.74 378 208304 31546 46445834
Blood glucose increased 131.06 9.74 653 208029 71360 46406020
Hypertension 128.32 9.74 1392 207290 194964 46282416
C-reactive protein increased 121.16 9.74 55 208627 58535 46418845
Pemphigus 121.06 9.74 27 208655 45247 46432133
Systemic lupus erythematosus 110.67 9.74 78 208604 65102 46412278
Treatment failure 110.19 9.74 153 208529 92934 46384446
Febrile neutropenia 108.57 9.74 159 208523 94468 46382912
Drug hypersensitivity 104.04 9.74 1598 207084 242227 46235153
Hyperkalaemia 103.98 9.74 476 208206 50233 46427147
Abortion spontaneous 101.75 9.74 34 208648 43612 46433768
Interstitial lung disease 99.16 9.74 59 208623 53890 46423490
Completed suicide 97.82 9.74 1040 207642 144880 46332500
Neutropenia 94.38 9.74 326 208356 142878 46334502
Renal failure 82.95 9.74 824 207858 112770 46364610
Lactic acidosis 80.75 9.74 333 208349 33576 46443804
Hepatic function abnormal 79.91 9.74 27 208655 34394 46442986
Dehydration 78.82 9.74 1073 207609 158467 46318913
Hand deformity 77.06 9.74 29 208653 34545 46442835
Lower respiratory tract infection 75.25 9.74 81 208601 55008 46422372
Pancreatitis 74.72 9.74 389 208293 43238 46434142
General physical health deterioration 74.61 9.74 266 208416 115503 46361877
Product dose omission issue 67.80 9.74 1094 207588 167426 46309954
Coronary arterial stent insertion 67.13 9.74 73 208609 2780 46474600
Hypotensive transfusion reaction 66.80 9.74 19 208663 28 46477352
Blood pressure increased 65.46 9.74 859 207823 125807 46351573
Pregnancy 65.27 9.74 20 208662 27117 46450263
Dizziness 64.30 9.74 1983 206699 338431 46138949
Chest pain 63.75 9.74 1125 207557 175199 46302181
Blood pressure inadequately controlled 61.95 9.74 87 208595 4319 46473061
Premature delivery 61.39 9.74 12 208670 22057 46455323
Swelling face 60.75 9.74 426 208256 52633 46424747
Mental status changes 60.05 9.74 332 208350 37756 46439624
Product use issue 59.96 9.74 219 208463 94425 46382955
Foetal exposure during pregnancy 57.38 9.74 33 208649 30714 46446666
Labile blood pressure 55.53 9.74 52 208630 1651 46475729
Agranulocytosis 53.99 9.74 16 208666 22169 46455211
Leukopenia 53.25 9.74 144 208538 68199 46409181
Hypovolaemia 52.32 9.74 128 208554 9760 46467620
Overdose 52.23 9.74 256 208426 101723 46375657
Chronic kidney disease 51.48 9.74 336 208346 40535 46436845
Cytomegalovirus infection 50.18 9.74 10 208672 18134 46459246
Coronary artery bypass 49.74 9.74 58 208624 2387 46474993
Infection 49.69 9.74 371 208311 133221 46344159
Cough 49.07 9.74 1362 207320 228887 46248493
Malignant neoplasm progression 47.49 9.74 141 208541 64785 46412595
Intentional self-injury 46.45 9.74 25 208657 24141 46453239
Type 2 diabetes mellitus 46.39 9.74 194 208488 19681 46457699
Angina unstable 44.60 9.74 102 208580 7446 46469934
Product complaint 44.43 9.74 137 208545 11964 46465416
Diarrhoea 44.39 9.74 2984 205698 556618 45920762
Drug reaction with eosinophilia and systemic symptoms 44.32 9.74 40 208642 29508 46447872
Rheumatoid factor positive 44.21 9.74 18 208664 20443 46456937
Product use in unapproved indication 43.73 9.74 231 208451 90042 46387338
Therapeutic product effect incomplete 43.69 9.74 190 208492 77963 46399417
Coma 43.19 9.74 126 208556 58223 46419157
Glossodynia 43.07 9.74 83 208599 44290 46433090
Hepatocellular injury 43.05 9.74 41 208641 29481 46447899
Mucosal inflammation 42.27 9.74 68 208614 38908 46438472
Suicide attempt 41.35 9.74 118 208564 54918 46422462
Anti-cyclic citrullinated peptide antibody positive 41.11 9.74 17 208665 19128 46458252
Hypotension 40.97 9.74 1344 207338 231245 46246135
Oxygen saturation decreased 39.98 9.74 166 208516 68998 46408382
Asthenia 39.83 9.74 1735 206947 309340 46168040
Therapeutic product effect decreased 39.66 9.74 212 208470 82389 46394991
Foetal methotrexate syndrome 39.53 9.74 14 208668 56 46477324
Intentional overdose 39.35 9.74 153 208529 64791 46412589
Premature baby 39.03 9.74 16 208666 18096 46459284
Sopor 38.87 9.74 20 208662 19808 46457572
Thrombocytopenia 38.74 9.74 370 208312 126211 46351169
Hepatic enzyme increased 38.67 9.74 211 208471 81576 46395804
Altered state of consciousness 38.24 9.74 29 208653 23319 46454061
Psoriasis 37.27 9.74 525 208157 78079 46399301
Arthralgia 37.05 9.74 1296 207386 363307 46114073
Caesarean section 36.87 9.74 14 208668 16589 46460791
Renal injury 35.94 9.74 109 208573 9432 46467948
Nausea 35.82 9.74 3550 205132 683904 45793476
Inflammation 35.62 9.74 106 208576 48675 46428705
Pericarditis 35.16 9.74 33 208649 23894 46453486
Musculoskeletal stiffness 35.07 9.74 275 208407 97718 46379662
Joint swelling 34.90 9.74 527 208155 165546 46311834
Gastrointestinal haemorrhage 34.78 9.74 512 208170 76861 46400519
Glycosylated haemoglobin increased 34.38 9.74 117 208565 10759 46466621
Transient ischaemic attack 34.14 9.74 270 208412 34633 46442747
Atrioventricular block second degree 33.99 9.74 61 208621 3738 46473642
Pulseless electrical activity 33.98 9.74 89 208593 7078 46470302
Angina pectoris 33.03 9.74 219 208463 26556 46450824
Somatic delusion 33.01 9.74 25 208657 588 46476792
Ischaemic cardiomyopathy 32.99 9.74 49 208633 2561 46474819
Pancreatitis acute 32.87 9.74 207 208475 24665 46452715
Arteriosclerosis 32.81 9.74 107 208575 9626 46467754
Status epilepticus 32.38 9.74 11 208671 13968 46463412
Epilepsy 32.30 9.74 35 208647 23703 46453677
Toxic skin eruption 31.90 9.74 8 208674 12379 46465001
Hypoaldosteronism 31.75 9.74 16 208666 175 46477205
Arthropathy 31.58 9.74 235 208447 84465 46392915
Pneumonia 30.96 9.74 1371 207311 374949 46102431
Blood glucose decreased 30.66 9.74 166 208516 18726 46458654
Atrioventricular block first degree 30.55 9.74 78 208604 6108 46471272
Wound 30.54 9.74 94 208588 42708 46434672
Cardiac disorder 30.46 9.74 315 208367 43543 46433837
Device expulsion 29.91 9.74 48 208634 27494 46449886
Atrial fibrillation 29.61 9.74 638 208044 102952 46374428
Hyperlipidaemia 29.48 9.74 162 208520 18377 46459003
Nasopharyngitis 29.24 9.74 498 208184 153500 46323880
Bone marrow failure 29.22 9.74 55 208627 29614 46447766
Drug resistance 29.18 9.74 21 208661 17347 46460033
Blood loss anaemia 28.78 9.74 94 208588 8463 46468917
Depressed level of consciousness 28.22 9.74 113 208569 47456 46429924
Blood sodium decreased 28.20 9.74 180 208502 21546 46455834
Condition aggravated 28.19 9.74 857 207825 244195 46233185
Cardiomyopathy 27.98 9.74 144 208538 15929 46461451
Neutrophil count decreased 27.81 9.74 100 208582 43326 46434054
Infective pulmonary exacerbation of cystic fibrosis 27.79 9.74 7 208675 10800 46466580
Hepatotoxicity 27.72 9.74 43 208639 24966 46452414
Pneumocystis jirovecii pneumonia 27.56 9.74 17 208665 15231 46462149
Erythema 27.39 9.74 461 208221 142359 46335021
Vision blurred 26.80 9.74 503 208179 79205 46398175
Arterial occlusive disease 26.29 9.74 63 208619 4741 46472639
Alopecia 26.25 9.74 540 208142 161874 46315506
Gamma-glutamyltransferase increased 26.15 9.74 65 208617 31675 46445705
Sight disability 25.64 9.74 12 208670 110 46477270
Blood potassium increased 25.48 9.74 146 208536 16821 46460559
Coronary artery occlusion 25.47 9.74 87 208595 8015 46469365
Pancytopenia 25.43 9.74 250 208432 84808 46392572
Colitis ulcerative 25.42 9.74 25 208657 17707 46459673
Colitis ischaemic 25.30 9.74 101 208581 10031 46467349
Abnormal dreams 25.30 9.74 102 208580 10177 46467203
Progressive multifocal leukoencephalopathy 24.48 9.74 10 208672 11336 46466044
Dysgeusia 24.07 9.74 282 208400 40209 46437171
Factor VII deficiency 23.86 9.74 8 208674 26 46477354
Septic shock 23.85 9.74 156 208526 57737 46419643
Neurotoxicity 23.82 9.74 16 208666 13701 46463679
Foetal death 23.80 9.74 5 208677 8738 46468642
Drug dispensed to wrong patient 23.64 9.74 14 208668 215 46477165
Tongue oedema 23.52 9.74 54 208628 3952 46473428
Synostosis 23.34 9.74 9 208673 48 46477332
Fall 23.22 9.74 1739 206943 327358 46150022
Lung disorder 23.16 9.74 107 208575 43197 46434183
Lymphopenia 22.58 9.74 21 208661 15272 46462108
Thermohypoaesthesia 22.51 9.74 11 208671 112 46477268
Drug eruption 22.39 9.74 38 208644 21291 46456089
Lymphomatoid papulosis 22.26 9.74 11 208671 115 46477265
Suspected suicide 22.22 9.74 58 208624 4603 46472777
Cholestasis 22.22 9.74 55 208627 26838 46450542
Eosinophilic oesophagitis 22.05 9.74 13 208669 198 46477182
Osmolar gap increased 21.80 9.74 7 208675 19 46477361
Liver disorder 21.76 9.74 89 208593 37157 46440223
Memory impairment 21.67 9.74 475 208207 76862 46400518
Alanine aminotransferase increased 21.67 9.74 272 208410 88179 46389201
Encephalomalacia 21.54 9.74 18 208664 490 46476890
Salivary gland enlargement 21.43 9.74 16 208666 368 46477012
Rheumatoid nodule 21.07 9.74 7 208675 9013 46468367
Gangrene 20.94 9.74 57 208625 4638 46472742
Bone erosion 20.91 9.74 8 208674 9435 46467945
Sinus arrhythmia 20.85 9.74 28 208654 1332 46476048
Aspergillus infection 20.81 9.74 3 208679 6887 46470493
Asthma 20.78 9.74 286 208396 91256 46386124
Rash maculo-papular 20.76 9.74 60 208622 27814 46449566
Neutropenic sepsis 20.58 9.74 15 208667 12309 46465071
Eosinophilia 20.39 9.74 34 208648 19183 46458197
Nodular rash 20.11 9.74 12 208670 187 46477193
Muscle spasms 20.01 9.74 705 207977 122408 46354972
Myocardial ischaemia 20.00 9.74 111 208571 12638 46464742
Blood potassium decreased 19.99 9.74 259 208423 37804 46439576
Nodal rhythm 19.85 9.74 31 208651 1694 46475686
Syncope 19.82 9.74 611 208071 104192 46373188
Dilatation atrial 19.77 9.74 35 208647 2122 46475258
Extrapyramidal disorder 19.76 9.74 13 208669 11255 46466125
Product quality issue 19.76 9.74 245 208437 35403 46441977
Graft versus host disease 19.60 9.74 3 208679 6585 46470795
Adactyly 19.57 9.74 7 208675 29 46477351
Diabetic ketoacidosis 19.56 9.74 144 208538 18066 46459314
Spinal stenosis 19.54 9.74 109 208573 12434 46464946
Dysphagia 19.54 9.74 468 208214 76844 46400536
Tuberculosis 19.18 9.74 11 208671 10254 46467126
Abortion induced 19.16 9.74 11 208671 10249 46467131
Tenosynovitis 19.07 9.74 5 208677 7510 46469870
Diabetic neuropathy 18.94 9.74 48 208634 3741 46473639
Blood pressure fluctuation 18.91 9.74 71 208611 30377 46447003
Hepatitis 18.81 9.74 77 208605 32138 46445242
Haematotoxicity 18.80 9.74 4 208678 6929 46470451
Ventricular hypertrophy 18.74 9.74 48 208634 3766 46473614
Feeling abnormal 18.59 9.74 709 207973 124351 46353029
Haemophagocytic lymphohistiocytosis 18.58 9.74 7 208675 8335 46469045
Thrombotic microangiopathy 18.45 9.74 7 208675 8299 46469081
Upper gastrointestinal haemorrhage 18.34 9.74 133 208549 16605 46460775
Fear of eating 18.25 9.74 14 208668 336 46477044
Muscle rigidity 18.15 9.74 11 208671 9950 46467430
Nervousness 18.13 9.74 201 208481 28274 46449106
BRASH syndrome 17.97 9.74 9 208673 97 46477283
International normalised ratio increased 17.94 9.74 302 208380 46581 46430799
Body height decreased 17.88 9.74 88 208594 9564 46467816
Allergic cough 17.84 9.74 16 208666 480 46476900
Chronic obstructive pulmonary disease 17.78 9.74 359 208323 57274 46420106
Drug clearance decreased 17.67 9.74 23 208659 1061 46476319
Hepatic ischaemia 17.57 9.74 16 208666 490 46476890
Peritonitis 17.39 9.74 42 208640 20672 46456708
Oral herpes 17.35 9.74 38 208644 19352 46458028
Red blood cell sedimentation rate increased 17.24 9.74 49 208633 22840 46454540
Gout 17.24 9.74 98 208584 11258 46466122
Dystonia 17.17 9.74 15 208667 11242 46466138
Shock 17.17 9.74 161 208521 21684 46455696
Uraemic encephalopathy 17.06 9.74 11 208671 198 46477182
Injury 16.99 9.74 284 208398 43743 46433637
Stridor 16.93 9.74 41 208641 3106 46474274
Myalgia 16.93 9.74 692 207990 122396 46354984
Oedema mouth 16.89 9.74 36 208646 2505 46474875
Tachycardia 16.75 9.74 329 208353 99293 46378087
Stomatitis 16.74 9.74 210 208472 68087 46409293
Live birth 16.70 9.74 13 208669 10317 46467063
Charles Bonnet syndrome 16.63 9.74 5 208677 10 46477370
Diverticulum 16.55 9.74 96 208586 11110 46466270
Hypergammaglobulinaemia 16.53 9.74 15 208667 457 46476923
Muscle relaxant therapy 16.31 9.74 9 208673 120 46477260
Suspected suicide attempt 16.24 9.74 9 208673 121 46477259
Lacunar infarction 16.24 9.74 43 208639 3442 46473938
Fluid intake reduced 16.16 9.74 42 208640 3324 46474056
Premature labour 16.12 9.74 16 208666 11283 46466097
Peripheral vascular disorder 16.08 9.74 61 208621 5916 46471464
Essential hypertension 16.01 9.74 49 208633 4261 46473119
Body temperature decreased 15.89 9.74 22 208660 13387 46463993
Device difficult to use 15.80 9.74 8 208674 7996 46469384
Therapy cessation 15.62 9.74 185 208497 26444 46450936
Anhedonia 15.56 9.74 89 208593 10246 46467134
Transcription medication error 15.51 9.74 10 208672 180 46477200
Acne 15.48 9.74 42 208640 19877 46457503
Device dislocation 15.47 9.74 48 208634 21754 46455626
Body temperature increased 15.42 9.74 58 208624 24803 46452577
Blood pressure systolic abnormal 15.34 9.74 3 208679 5514 46471866
Pneumonitis 15.33 9.74 70 208612 28350 46449030
Electrocardiogram T wave abnormal 15.32 9.74 33 208649 2313 46475067
Sedation 15.17 9.74 52 208630 22858 46454522
Low birth weight baby 15.02 9.74 3 208679 5431 46471949
Liver function test increased 14.99 9.74 52 208630 22774 46454606
Mydriasis 14.99 9.74 15 208667 10538 46466842
Weight decreased 14.81 9.74 1114 207568 209735 46267645
Accelerated hypertension 14.75 9.74 13 208669 381 46476999
Full blood count decreased 14.70 9.74 158 208524 22053 46455327
Epstein-Barr virus infection 14.60 9.74 6 208676 6778 46470602
Lichen planus 14.60 9.74 28 208654 1805 46475575
Transient psychosis 14.57 9.74 6 208676 39 46477341
Generalised tonic-clonic seizure 14.51 9.74 67 208615 27055 46450325
Neuroleptic malignant syndrome 14.47 9.74 17 208665 11105 46466275
Electrocardiogram T wave peaked 14.47 9.74 10 208672 203 46477177
Oedema peripheral 14.46 9.74 862 207820 158844 46318536
Transplant rejection 14.38 9.74 13 208669 9583 46467797
Productive cough 14.35 9.74 151 208531 50564 46426816
Pre-eclampsia 14.33 9.74 9 208673 7985 46469395
Cerebral atrophy 14.27 9.74 50 208632 4666 46472714
Panniculitis 14.09 9.74 4 208678 5700 46471680
Product coating issue 14.08 9.74 6 208676 43 46477337
Application site nodule 14.02 9.74 4 208678 6 46477374
Urethral prolapse 14.02 9.74 4 208678 6 46477374
Product substitution issue 14.00 9.74 115 208567 14916 46462464
Metastases to liver 13.98 9.74 43 208639 19542 46457838
Blood pressure abnormal 13.92 9.74 98 208584 12119 46465261
Mitral valve incompetence 13.86 9.74 137 208545 18715 46458665
Respiratory depression 13.78 9.74 19 208663 11581 46465799
Shock haemorrhagic 13.76 9.74 11 208671 8613 46468767
Forced expiratory volume decreased 13.73 9.74 3 208679 5101 46472279
Hepatorenal syndrome 13.65 9.74 27 208655 1781 46475599
Pathogen resistance 13.64 9.74 5 208677 6055 46471325
Oral candidiasis 13.60 9.74 37 208645 17495 46459885
Hypophagia 13.58 9.74 195 208487 29111 46448269
Schizophrenia 13.58 9.74 11 208671 8557 46468823
Dizziness postural 13.57 9.74 61 208621 6385 46470995
Ventricular fibrillation 13.56 9.74 93 208589 11403 46465977
Cerebral thrombosis 13.55 9.74 26 208656 1677 46475703
Factor VIII inhibition 13.52 9.74 6 208676 48 46477332
Myelosuppression 13.36 9.74 9 208673 7694 46469686
Pulmonary arterial hypertension 13.31 9.74 65 208617 25863 46451517
Paramnesia 13.30 9.74 4 208678 8 46477372
Autonomic failure syndrome 13.25 9.74 3 208679 0 46477380
Acute myeloid leukaemia 13.24 9.74 32 208650 15746 46461634
Catheterisation cardiac 13.20 9.74 44 208638 4003 46473377
Fear 13.11 9.74 120 208562 16052 46461328
Nephrogenic systemic fibrosis 13.09 9.74 49 208633 4723 46472657
Pharyngitis 12.98 9.74 38 208644 17545 46459835
Blood electrolytes abnormal 12.98 9.74 19 208663 980 46476400
Bezoar 12.97 9.74 23 208659 1396 46475984
Feeling jittery 12.95 9.74 89 208593 10919 46466461
Dry mouth 12.83 9.74 329 208353 54597 46422783
Stevens-Johnson syndrome 12.79 9.74 57 208625 23240 46454140
Carotid artery stenosis 12.75 9.74 51 208631 5069 46472311
Osteoporosis 12.71 9.74 118 208564 40490 46436890
Depression 12.67 9.74 903 207779 169201 46308179
Product availability issue 12.64 9.74 20 208662 1105 46476275
Cytokine release syndrome 12.61 9.74 6 208676 6217 46471163
Pharyngeal oedema 12.57 9.74 109 208573 14362 46463018
Chorioretinitis 12.55 9.74 11 208671 320 46477060
Pneumonia viral 12.52 9.74 7 208675 6617 46470763
Craniosynostosis 12.50 9.74 8 208674 142 46477238
Device related infection 12.47 9.74 50 208632 20991 46456389
Mobility decreased 12.46 9.74 193 208489 60401 46416979
Facial nerve disorder 12.38 9.74 14 208668 557 46476823
Second primary malignancy 12.38 9.74 7 208675 6577 46470803
Rectal haemorrhage 12.37 9.74 240 208442 38015 46439365
Therapeutic response unexpected 12.22 9.74 115 208567 15501 46461879
Flatulence 12.16 9.74 189 208493 28689 46448691
Administration site discomfort 12.14 9.74 7 208675 102 46477278
Faeces pale 12.04 9.74 23 208659 1479 46475901
Blood creatinine increased 12.03 9.74 436 208246 75967 46401413
Polyneuropathy 11.99 9.74 21 208661 11623 46465757
Mouth swelling 11.94 9.74 40 208642 3649 46473731
Ageusia 11.91 9.74 90 208592 11382 46465998
Palmar-plantar erythrodysaesthesia syndrome 11.86 9.74 49 208633 20402 46456978
Gait disturbance 11.84 9.74 777 207905 144486 46332894
Acute interstitial pneumonitis 11.81 9.74 15 208667 675 46476705
Raynaud's phenomenon 11.79 9.74 21 208661 1279 46476101
Nephropathy 11.79 9.74 49 208633 4956 46472424
Laryngotracheal oedema 11.72 9.74 5 208677 36 46477344
Retching 11.68 9.74 99 208583 12958 46464422
Expired product administered 11.68 9.74 53 208629 5569 46471811
Non-cardiac chest pain 11.68 9.74 56 208626 6022 46471358
Osteonecrosis of jaw 11.63 9.74 98 208584 34304 46443076
Eosinophilic pneumonia acute 11.62 9.74 11 208671 354 46477026
Balance disorder 11.62 9.74 374 208308 64147 46413233
Diffuse large B-cell lymphoma 11.62 9.74 6 208676 5932 46471448
Cholelithiasis 11.61 9.74 240 208442 38441 46438939
Rash 11.59 9.74 1406 207276 355106 46122274
Poor venous access 11.58 9.74 12 208670 8296 46469084
Poisoning deliberate 11.56 9.74 11 208671 7915 46469465
Lymphocyte count decreased 11.55 9.74 67 208615 25522 46451858
Burn oesophageal 11.51 9.74 8 208674 164 46477216
Gastric ulcer helicobacter 11.49 9.74 4 208678 15 46477365
Ovarian cyst 11.49 9.74 29 208653 14058 46463322
Diabetic gastroparesis 11.49 9.74 9 208673 223 46477157
Back disorder 11.41 9.74 75 208607 9066 46468314
Immune thrombocytopenia 11.38 9.74 12 208670 8229 46469151
Multimorbidity 11.34 9.74 15 208667 703 46476677
Tonsillitis 11.34 9.74 4 208678 4960 46472420
Upper airway obstruction 11.30 9.74 13 208669 527 46476853
Cardioactive drug level increased 11.26 9.74 27 208655 2032 46475348
Apparent death 11.22 9.74 21 208661 1329 46476051
Renal tubular acidosis 11.19 9.74 23 208659 1560 46475820
Pancreatic calcification 11.18 9.74 3 208679 3 46477377
Ischaemic neuropathy 11.18 9.74 3 208679 3 46477377
Gastrooesophageal reflux disease 11.16 9.74 422 208260 73922 46403458
Asymptomatic bacteriuria 11.14 9.74 6 208676 76 46477304
Blood urea increased 11.09 9.74 167 208515 25185 46452195
Hypogeusia 11.03 9.74 18 208664 1021 46476359
Respiratory disorder 11.02 9.74 74 208608 27226 46450154
Visual acuity reduced 11.00 9.74 149 208533 21964 46455416
Rotator cuff repair 10.98 9.74 22 208660 1465 46475915
Bundle branch block left 10.91 9.74 57 208625 6342 46471038
Tarsal tunnel syndrome 10.84 9.74 14 208668 641 46476739
Product solubility abnormal 10.78 9.74 16 208666 836 46476544
Macular fibrosis 10.77 9.74 11 208671 389 46476991
Erythema marginatum 10.75 9.74 4 208678 19 46477361
Abdominal discomfort 10.75 9.74 559 208123 150606 46326774
Disseminated intravascular coagulation 10.74 9.74 46 208636 18959 46458421
Demyelination 10.74 9.74 6 208676 5674 46471706
Glomerulonephritis membranous 10.72 9.74 13 208669 558 46476822
Immunodeficiency 10.67 9.74 27 208655 13079 46464301
Blood urea abnormal 10.66 9.74 13 208669 561 46476819
Optic ischaemic neuropathy 10.66 9.74 17 208665 946 46476434
Eye swelling 10.64 9.74 137 208545 19966 46457414
Infusion site pain 10.62 9.74 18 208664 10089 46467291
Hyperbilirubinaemia 10.59 9.74 19 208663 10419 46466961
Acute generalised exanthematous pustulosis 10.59 9.74 16 208666 9389 46467991
Osteoarthritis 10.52 9.74 357 208325 61668 46415712
High density lipoprotein abnormal 10.49 9.74 5 208677 48 46477332
Venoocclusive liver disease 10.46 9.74 3 208679 4248 46473132
Chromatopsia 10.46 9.74 12 208670 485 46476895
Ventricular tachycardia 10.45 9.74 119 208563 16848 46460532
Unresponsive to stimuli 10.45 9.74 202 208480 31972 46445408
Urine abnormality 10.44 9.74 6 208676 5588 46471792
Insomnia 10.37 9.74 864 207818 164060 46313320
Hyponatraemia 10.34 9.74 553 208129 100779 46376601
SUNCT syndrome 10.32 9.74 3 208679 5 46477375
Retroperitoneal oedema 10.27 9.74 4 208678 22 46477358
Confusional state 10.27 9.74 839 207843 159053 46318327
Blood lactate dehydrogenase increased 10.18 9.74 52 208630 20448 46456932
Fatigue 10.10 9.74 2957 205725 605740 45871640
Blood glucose fluctuation 10.09 9.74 41 208641 4105 46473275
Occult blood positive 10.08 9.74 37 208645 3533 46473847
Choroidal effusion 10.03 9.74 11 208671 423 46476957
Umbilical hernia, obstructive 9.98 9.74 3 208679 6 46477374
Jaundice cholestatic 9.96 9.74 5 208677 5024 46472356
Haemodialysis 9.96 9.74 73 208609 9144 46468236
Product residue present 9.94 9.74 39 208643 3843 46473537
Sarcoma 9.92 9.74 11 208671 428 46476952
Haemorrhagic hepatic cyst 9.85 9.74 4 208678 25 46477355
Fracture 9.85 9.74 39 208643 16432 46460948
Folliculitis 9.78 9.74 8 208674 6195 46471185
Urinary tract candidiasis 9.75 9.74 12 208670 523 46476857

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 10461.53 10.57 4893 190875 29491 29727219
Cardiac failure congestive 579.70 10.57 1525 194243 82882 29673828
Myocardial infarction 554.95 10.57 1943 193825 123682 29633028
Swollen tongue 517.36 10.57 529 195239 12663 29744047
Hyperkalaemia 508.61 10.57 1246 194522 64764 29691946
Lip swelling 479.85 10.57 500 195268 12244 29744466
Coronary artery disease 341.69 10.57 899 194869 48813 29707897
Acute kidney injury 283.32 10.57 2881 192887 270961 29485749
Drug abuse 270.62 10.57 99 195669 81973 29674737
Off label use 252.16 10.57 814 194954 248476 29508234
Pyrexia 248.44 10.57 1037 194731 293452 29463258
Cerebrovascular accident 239.94 10.57 1131 194637 82346 29674364
Swelling face 218.82 10.57 450 195318 20754 29735956
Febrile neutropenia 217.27 10.57 226 195542 106467 29650243
Completed suicide 200.01 10.57 1222 194546 98270 29658440
General physical health deterioration 198.68 10.57 216 195552 99728 29656982
Interstitial lung disease 194.40 10.57 75 195693 60122 29696588
Neutropenia 188.71 10.57 345 195423 128195 29628515
Hypotension 175.78 10.57 2043 193725 198522 29558188
Foetal exposure during pregnancy 150.70 10.57 29 195739 36842 29719868
Acute myocardial infarction 141.69 10.57 703 195065 52236 29704474
Dizziness 140.57 10.57 1915 193853 192994 29563716
Hepatic function abnormal 134.18 10.57 53 195715 41892 29714818
Pancreatitis 119.38 10.57 514 195254 35976 29720734
Coronary arterial stent insertion 119.02 10.57 142 195626 4052 29752658
Thrombocytopenia 116.72 10.57 480 195288 136564 29620146
Intestinal angioedema 114.83 10.57 43 195725 129 29756581
Drug hypersensitivity 112.30 10.57 800 194968 67719 29688991
Septic shock 108.97 10.57 154 195614 63453 29693257
C-reactive protein increased 101.59 10.57 81 195687 43392 29713318
Product use in unapproved indication 99.19 10.57 208 195560 73485 29683225
Coronary artery bypass 88.75 10.57 137 195631 5025 29751685
Pharyngeal oedema 87.34 10.57 154 195614 6317 29750393
Hepatocellular injury 86.85 10.57 29 195739 25442 29731268
Leukopenia 86.58 10.57 146 195622 56013 29700697
Cytomegalovirus infection 86.05 10.57 24 195744 23650 29733060
Cholestasis 85.78 10.57 28 195740 24922 29731788
Disseminated intravascular coagulation 85.34 10.57 20 195748 22151 29734559
Agranulocytosis 84.05 10.57 20 195748 21922 29734788
Dehydration 81.70 10.57 1196 194572 122343 29634367
Pneumonia 75.80 10.57 1638 194130 332668 29424042
Blood potassium increased 74.95 10.57 255 195513 15958 29740752
Anaphylactic reaction 74.40 10.57 371 195397 27611 29729099
Bone marrow failure 74.08 10.57 52 195716 29733 29726977
Hypotensive transfusion reaction 74.06 10.57 20 195748 8 29756702
Drug resistance 72.08 10.57 21 195747 20112 29736598
Rheumatoid arthritis 68.32 10.57 102 195666 41095 29715615
Lactic acidosis 66.81 10.57 390 195378 30823 29725887
Neutrophil count decreased 66.70 10.57 109 195659 42345 29714365
Altered state of consciousness 65.64 10.57 24 195744 19895 29736815
Bronchopulmonary aspergillosis 64.31 10.57 4 195764 12280 29744430
Pancytopenia 61.55 10.57 316 195452 84736 29671974
Hypovolaemia 60.44 10.57 157 195611 8448 29748262
Drug ineffective 59.74 10.57 1732 194036 338655 29418055
Product dose omission issue 58.53 10.57 882 194886 90749 29665961
Treatment failure 58.34 10.57 85 195683 34594 29722116
Epilepsy 57.44 10.57 30 195738 20139 29736571
Blood glucose increased 57.35 10.57 635 195133 60895 29695815
Cough 55.40 10.57 1140 194628 124502 29632208
Coma 54.54 10.57 114 195654 40335 29716375
Death 54.45 10.57 1852 193916 355431 29401279
Gamma-glutamyltransferase increased 53.35 10.57 68 195700 29282 29727428
Hypertension 52.49 10.57 1098 194670 120256 29636454
Sepsis 51.94 10.57 660 195108 145735 29610975
Chest pain 51.11 10.57 1065 194703 116562 29640148
Blood pressure inadequately controlled 51.06 10.57 73 195695 2497 29754213
Mental status changes 49.05 10.57 412 195356 36667 29720043
Toxic skin eruption 48.69 10.57 7 195761 11008 29745702
Blood lactate dehydrogenase increased 48.60 10.57 38 195730 20563 29736147
Sopor 48.55 10.57 7 195761 10984 29745726
Diabetic neuropathy 48.07 10.57 90 195678 3869 29752841
Malignant neoplasm progression 47.13 10.57 278 195490 72009 29684701
Oral allergy syndrome 45.95 10.57 14 195754 16 29756694
Condition aggravated 45.81 10.57 630 195138 137236 29619474
Product use issue 45.77 10.57 151 195617 45865 29710845
Pneumocystis jirovecii pneumonia 45.12 10.57 28 195740 17092 29739618
Syncope 44.81 10.57 792 194976 84111 29672599
Immune reconstitution inflammatory syndrome 44.69 10.57 4 195764 9097 29747613
Premature baby 44.41 10.57 27 195741 16664 29740046
Synovitis 43.75 10.57 6 195762 9777 29746933
Platelet count decreased 43.62 10.57 463 195305 105666 29651044
Seizure 42.78 10.57 424 195344 98051 29658659
Mucosal inflammation 42.76 10.57 84 195684 30410 29726300
Infection 41.99 10.57 318 195450 77756 29678954
Intentional self-injury 41.80 10.57 18 195750 13514 29743196
Lymphocyte count decreased 41.45 10.57 38 195730 19017 29737693
Alanine aminotransferase increased 41.16 10.57 300 195468 73976 29682734
Hyperthermia 41.13 10.57 8 195760 10091 29746619
Psoriasis 40.66 10.57 441 195327 42065 29714645
Lower respiratory tract infection 40.65 10.57 70 195698 26644 29730066
Multiple organ dysfunction syndrome 40.41 10.57 246 195522 63241 29693469
Liver disorder 39.87 10.57 84 195684 29638 29727072
Suspected suicide 39.81 10.57 73 195695 3088 29753622
Cardiac failure 39.29 10.57 352 195416 83066 29673644
Fatigue 39.26 10.57 2512 193256 318161 29438549
Wheezing 38.42 10.57 339 195429 30599 29726111
Renal tubular necrosis 37.59 10.57 198 195570 15053 29741657
Dysphagia 37.44 10.57 549 195219 56149 29700561
Drug interaction 37.04 10.57 1007 194761 198561 29558149
Lymphopenia 36.86 10.57 20 195748 13143 29743567
Renal injury 36.64 10.57 163 195605 11566 29745144
Hyperbilirubinaemia 36.60 10.57 34 195734 16908 29739802
Lung disorder 36.56 10.57 96 195672 31373 29725337
Infusion related reaction 36.41 10.57 139 195629 40425 29716285
Vascular graft 36.02 10.57 46 195722 1409 29755301
Depressed level of consciousness 35.60 10.57 129 195639 38093 29718617
Cardiac disorder 35.03 10.57 407 195361 39486 29717224
Electrocardiogram T wave peaked 34.73 10.57 28 195740 486 29756224
Exposure during pregnancy 34.38 10.57 9 195759 9252 29747458
Injury 33.98 10.57 251 195517 21480 29735230
Dysphonia 33.96 10.57 227 195541 18805 29737905
Ischaemic cardiomyopathy 33.58 10.57 104 195664 6193 29750517
Hepatitis 32.73 10.57 60 195708 22296 29734414
Pancreatitis acute 32.65 10.57 283 195485 25412 29731298
Aspergillus infection 32.50 10.57 13 195755 10201 29746509
Graft versus host disease 32.16 10.57 13 195755 10137 29746573
Haemophagocytic lymphohistiocytosis 31.91 10.57 12 195756 9779 29746931
Pathogen resistance 31.56 10.57 8 195760 8402 29748308
Drug reaction with eosinophilia and systemic symptoms 31.52 10.57 89 195679 28399 29728311
Bradycardia 31.33 10.57 602 195166 64924 29691786
Transient ischaemic attack 31.22 10.57 276 195492 24924 29731786
Tongue oedema 31.05 10.57 61 195707 2719 29753991
Aspartate aminotransferase increased 30.57 10.57 266 195502 63156 29693554
Drug dependence 30.43 10.57 58 195710 21237 29735473
Pneumonitis 30.21 10.57 86 195682 27368 29729342
International normalised ratio increased 29.86 10.57 458 195310 47281 29709429
Mouth swelling 29.70 10.57 44 195724 1555 29755155
Angina unstable 29.10 10.57 158 195610 12152 29744558
Thrombotic microangiopathy 29.00 10.57 10 195758 8600 29748110
Feeling abnormal 28.71 10.57 526 195242 56230 29700480
Intentional product use issue 28.30 10.57 132 195636 36308 29720402
Device interaction 28.26 10.57 23 195745 405 29756305
Drooling 27.78 10.57 61 195707 2944 29753766
Eosinophilia 27.77 10.57 65 195703 22095 29734615
Anaemia 27.75 10.57 1095 194673 206897 29549813
Fear 27.69 10.57 142 195626 10683 29746027
Transaminases increased 27.68 10.57 71 195697 23386 29733324
Pelvic mass 27.47 10.57 15 195753 129 29756581
Asthenia 27.46 10.57 1736 194032 219554 29537156
Muscle spasms 27.45 10.57 585 195183 64253 29692457
Venoocclusive liver disease 27.44 10.57 5 195763 6608 29750102
Pulmonary renal syndrome 27.44 10.57 16 195752 158 29756552
Blood glucose decreased 27.21 10.57 162 195606 12891 29743819
Infective pulmonary exacerbation of cystic fibrosis 27.12 10.57 11 195757 8561 29748149
Pneumonia aspiration 26.95 10.57 141 195627 37639 29719071
Status epilepticus 26.65 10.57 20 195748 11052 29745658
Blood pressure increased 26.40 10.57 636 195132 71292 29685418
Neuroleptic malignant syndrome 26.38 10.57 41 195727 16254 29740456
Asthma 26.37 10.57 134 195634 36040 29720670
Hypophagia 26.25 10.57 241 195527 21995 29734715
Encephalopathy 26.00 10.57 115 195653 32090 29724620
Dysgeusia 25.92 10.57 262 195506 24539 29732171
Substance abuse 25.84 10.57 7 195761 7033 29749677
Transplant rejection 25.76 10.57 14 195754 9192 29747518
Erythema 25.66 10.57 354 195414 77097 29679613
Ageusia 25.43 10.57 121 195647 8832 29747878
Drug-induced liver injury 25.40 10.57 64 195704 21210 29735500
Blood alkaline phosphatase increased 25.08 10.57 113 195655 31374 29725336
Drug intolerance 25.04 10.57 183 195585 45108 29711602
Blood creatinine increased 24.77 10.57 777 194991 90598 29666112
Mydriasis 24.74 10.57 5 195763 6138 29750572
Pancreatitis necrotising 24.69 10.57 51 195717 2358 29754352
Nodular rash 24.59 10.57 11 195757 58 29756652
Allergic cough 24.53 10.57 9 195759 25 29756685
Anhedonia 24.42 10.57 114 195654 8255 29748455
Oropharyngeal swelling 24.31 10.57 22 195746 450 29756260
Hyperlipidaemia 24.29 10.57 165 195603 13742 29742968
Myocardial ischaemia 24.28 10.57 195 195573 17122 29739588
Vision blurred 24.19 10.57 396 195372 41420 29715290
Emotional distress 24.03 10.57 181 195587 15584 29741126
Paraesthesia 23.92 10.57 493 195275 53834 29702876
Toxic epidermal necrolysis 23.81 10.57 51 195717 17889 29738821
Peritonitis 23.49 10.57 67 195701 21308 29735402
Blood urea increased 23.18 10.57 310 195458 31071 29725639
Acute hepatic failure 22.98 10.57 26 195742 11801 29744909
Haematotoxicity 22.90 10.57 6 195762 6164 29750546
Hypoglycaemia 22.56 10.57 463 195305 50518 29706192
Hepatocellular carcinoma 22.32 10.57 18 195750 9592 29747118
Epstein-Barr virus infection 22.23 10.57 8 195760 6698 29750012
Myelosuppression 22.20 10.57 10 195758 7312 29749398
Ulnar nerve palsy 22.11 10.57 7 195761 10 29756700
Orthostatic hypotension 22.11 10.57 247 195521 23732 29732978
Post transplant lymphoproliferative disorder 22.04 10.57 4 195764 5302 29751408
Product quality issue 21.92 10.57 203 195565 18571 29738139
Jaundice 21.65 10.57 124 195644 32362 29724348
Hepatic failure 21.60 10.57 132 195636 33911 29722799
Tuberculosis 21.58 10.57 13 195755 8064 29748646
Cystitis haemorrhagic 21.26 10.57 3 195765 4784 29751926
Blood bilirubin increased 21.24 10.57 146 195622 36490 29720220
Circulatory collapse 21.02 10.57 65 195703 20149 29736561
Similar reaction on previous exposure to drug 20.83 10.57 9 195759 43 29756667
Progressive multifocal leukoencephalopathy 20.79 10.57 17 195751 8996 29747714
Product complaint 20.70 10.57 84 195684 5722 29750988
Anal abscess 20.68 10.57 4 195764 5065 29751645
Posterior reversible encephalopathy syndrome 20.61 10.57 16 195752 8691 29748019
Glycosylated haemoglobin increased 20.57 10.57 119 195649 9372 29747338
Enterocolitis 20.49 10.57 9 195759 6678 29750032
Arteriosclerosis coronary artery 20.36 10.57 134 195634 11042 29745668
White blood cell count decreased 20.16 10.57 407 195361 83540 29673170
Urine oxalate increased 20.04 10.57 7 195761 16 29756694
Eosinophil count increased 20.00 10.57 12 195756 7461 29749249
Hepatic encephalopathy 19.98 10.57 39 195729 14153 29742557
Chronic kidney disease 19.95 10.57 353 195415 37485 29719225
Hypertensive emergency 19.83 10.57 26 195742 818 29755892
Schizophrenia 19.73 10.57 18 195750 9030 29747680
Device related infection 19.69 10.57 52 195716 16963 29739747
Neurotoxicity 19.64 10.57 35 195733 13147 29743563
Vitreous floaters 19.59 10.57 56 195712 3188 29753522
Labelled drug-drug interaction medication error 19.58 10.57 24 195744 10514 29746196
Myalgia 19.49 10.57 647 195121 76020 29680690
Delirium 19.31 10.57 171 195597 40460 29716250
Plasmapheresis 19.30 10.57 17 195751 335 29756375
Blood urea abnormal 19.28 10.57 23 195745 656 29756054
Encephalitis 19.19 10.57 9 195759 6427 29750283
Aggression 19.04 10.57 152 195616 36755 29719955
Increased tendency to bruise 18.96 10.57 59 195709 3522 29753188
Renal artery stenosis 18.93 10.57 39 195729 1800 29754910
Cholangitis 18.90 10.57 14 195754 7788 29748922
Laryngeal oedema 18.86 10.57 56 195712 3258 29753452
Acute respiratory distress syndrome 18.83 10.57 84 195684 23388 29733322
Tachycardia 18.77 10.57 354 195414 73385 29683325
Nausea 18.70 10.57 2215 193553 294742 29461968
Rash maculo-papular 18.61 10.57 94 195674 25324 29731386
No reaction on previous exposure to drug 18.61 10.57 10 195758 83 29756627
Product coating issue 18.45 10.57 7 195761 22 29756688
Oxygen saturation decreased 18.44 10.57 188 195580 43252 29713458
Colitis ulcerative 18.36 10.57 42 195726 14392 29742318
Pseudomonas infection 18.31 10.57 25 195743 10457 29746253
Diabetic foot infection 18.25 10.57 23 195745 695 29756015
Renal impairment neonatal 18.22 10.57 7 195761 23 29756687
Renal tubular acidosis 18.00 10.57 38 195730 1784 29754926
Hepatitis cholestatic 17.97 10.57 15 195753 7857 29748853
Acute myeloid leukaemia 17.96 10.57 59 195709 17947 29738763
Aplastic anaemia 17.79 10.57 7 195761 5549 29751161
Myelodysplastic syndrome 17.73 10.57 63 195705 18715 29737995
Hepatotoxicity 17.72 10.57 60 195708 18085 29738625
Oedema genital 17.53 10.57 16 195752 331 29756379
Kidney transplant rejection 17.52 10.57 14 195754 7495 29749215
Pharyngeal swelling 17.52 10.57 31 195737 1275 29755435
Product substitution issue 17.49 10.57 119 195649 9916 29746794
Pulmonary arterial hypertension 17.47 10.57 21 195747 9280 29747430
Osteonecrosis 17.42 10.57 51 195717 16084 29740626
Hypoaesthesia 17.39 10.57 471 195297 53759 29702951
Swelling 17.35 10.57 331 195437 35644 29721066
Chronic graft versus host disease 17.34 10.57 3 195765 4116 29752594
Prostate cancer recurrent 17.34 10.57 23 195745 732 29755978
Eye swelling 17.26 10.57 109 195659 8855 29747855
Osteonecrosis of jaw 17.22 10.57 63 195705 18555 29738155
Cachexia 17.16 10.57 11 195757 6600 29750110
Rash pruritic 17.09 10.57 224 195544 22348 29734362
Lip oedema 16.94 10.57 42 195726 2195 29754515
Generalised tonic-clonic seizure 16.90 10.57 68 195700 19483 29737227
Tumour lysis syndrome 16.79 10.57 37 195731 12848 29743862
Carcinoid tumour of the gastrointestinal tract 16.78 10.57 8 195760 50 29756660
Acquired acrodermatitis enteropathica 16.75 10.57 5 195763 5 29756705
Blood cholesterol increased 16.65 10.57 177 195591 16793 29739917
Electrocardiogram change 16.65 10.57 21 195747 635 29756075
Toxicity to various agents 16.62 10.57 968 194800 176215 29580495
Cardio-respiratory arrest 16.54 10.57 269 195499 57037 29699673
Drug level increased 16.40 10.57 63 195705 18291 29738419
Spur cell anaemia 16.39 10.57 8 195760 53 29756657
Hypoaesthesia oral 16.36 10.57 56 195712 3514 29753196
Cerebral infarction 16.35 10.57 103 195665 26270 29730440
Therapy cessation 16.34 10.57 161 195607 14976 29741734
Miosis 16.33 10.57 16 195752 7760 29748950
Renal failure 16.18 10.57 1013 194755 127953 29628757
Adenovirus infection 16.13 10.57 4 195764 4264 29752446
Accelerated hypertension 16.11 10.57 13 195755 226 29756484
Second primary malignancy 15.93 10.57 11 195757 6345 29750365
Maternal exposure during pregnancy 15.91 10.57 3 195765 3868 29752842
Dizziness postural 15.90 10.57 75 195693 5455 29751255
Colitis 15.87 10.57 127 195641 30693 29726017
Hyperuricaemia 15.78 10.57 15 195753 7379 29749331
Pulmonary tuberculosis 15.75 10.57 6 195762 4851 29751859
Arteriosclerosis 15.74 10.57 123 195645 10710 29746000
Hepatitis acute 15.55 10.57 14 195754 7069 29749641
Pleural effusion 15.50 10.57 367 195401 73699 29683011
Neutrophil count increased 15.42 10.57 50 195718 15273 29741437
Polyneuropathy 15.37 10.57 34 195734 11789 29744921
Conjunctival scar 15.35 10.57 8 195760 62 29756648
Gout 15.35 10.57 177 195591 17138 29739572
Burning sensation 15.32 10.57 170 195598 16304 29740406
Electrocardiogram QT prolonged 15.25 10.57 155 195613 35680 29721030
Complications of transplanted kidney 15.20 10.57 4 195764 4097 29752613
Respiratory tract oedema 15.17 10.57 16 195752 397 29756313
Psychomotor hyperactivity 15.00 10.57 19 195749 8205 29748505
Lymphoma 14.96 10.57 27 195741 10094 29746616
Oedema mouth 14.94 10.57 29 195739 1281 29755429
Hypotonia 14.94 10.57 14 195754 6934 29749776
Inflammation 14.72 10.57 84 195684 21942 29734768
Benign gastrointestinal neoplasm 14.57 10.57 10 195758 134 29756576
Enlarged uvula 14.51 10.57 10 195758 135 29756575
Epiglottic oedema 14.50 10.57 11 195757 174 29756536
Stridor 14.47 10.57 40 195728 2234 29754476
Stent placement 14.45 10.57 64 195704 4532 29752178
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.34 10.57 19 195749 604 29756106
Blood electrolytes abnormal 14.26 10.57 23 195745 876 29755834
Atrial fibrillation 14.25 10.57 853 194915 107271 29649439
Cytomegalovirus viraemia 14.24 10.57 10 195758 5719 29750991
Cytokine release syndrome 14.24 10.57 27 195741 9906 29746804
Coronary artery occlusion 14.23 10.57 123 195645 11034 29745676
Blood glucose abnormal 14.16 10.57 70 195698 5189 29751521
Carcinoid tumour of the stomach 14.14 10.57 7 195761 48 29756662
Essential hypertension 14.12 10.57 42 195726 2446 29754264
Stomatitis 13.97 10.57 166 195602 37113 29719597
Lymphomatoid papulosis 13.93 10.57 11 195757 185 29756525
Neutropenic sepsis 13.87 10.57 34 195734 11375 29745335
Pollakiuria 13.74 10.57 170 195598 16736 29739974
Facial asymmetry 13.59 10.57 13 195755 286 29756424
Candida infection 13.55 10.57 53 195715 15309 29741401
Nocardiosis 13.53 10.57 3 195765 3452 29753258
Hypocalcaemia 13.50 10.57 83 195685 21293 29735417
Oral candidiasis 13.45 10.57 33 195735 11038 29745672
Cognitive disorder 13.44 10.57 95 195673 23595 29733115
Diabetic retinopathy 13.41 10.57 33 195735 1717 29754993
Azotaemia 13.40 10.57 66 195702 4886 29751824
Speech disorder 13.39 10.57 230 195538 24282 29732428
Glomerular filtration rate abnormal 13.38 10.57 17 195751 518 29756192
Psychotic disorder 13.35 10.57 84 195684 21431 29735279
Drug eruption 13.30 10.57 64 195704 17462 29739248
Pemphigus 13.28 10.57 27 195741 1234 29755476
Sinus node dysfunction 13.23 10.57 55 195713 3788 29752922
Tympanic membrane disorder 13.21 10.57 6 195762 33 29756677
Serotonin syndrome 13.19 10.57 66 195702 17825 29738885
Unevaluable event 13.19 10.57 286 195482 31499 29725211
Cytopenia 13.15 10.57 21 195747 8235 29748475
Alcoholic ketoacidosis 13.11 10.57 5 195763 16 29756694
Throat tightness 12.96 10.57 86 195682 7106 29749604
Plasma cell myeloma 12.89 10.57 259 195509 53203 29703507
Hypergastrinaemia 12.78 10.57 6 195762 36 29756674
Food allergy 12.76 10.57 22 195746 886 29755824
Respiratory tract infection 12.74 10.57 55 195713 15451 29741259
Cataract nuclear 12.71 10.57 16 195752 483 29756227
Application site infection 12.65 10.57 6 195762 37 29756673
Dystonia 12.62 10.57 28 195740 9699 29747011
Haemorrhage intracranial 12.59 10.57 152 195616 14880 29741830
Akathisia 12.57 10.57 12 195756 5892 29750818
Productive cough 12.56 10.57 130 195638 29823 29726887
Hypertriglyceridaemia 12.52 10.57 21 195747 8077 29748633
Bronchospasm 12.42 10.57 31 195737 10307 29746403
Dermatitis bullous 12.32 10.57 13 195755 6091 29750619
Paraesthesia oral 12.29 10.57 52 195716 3609 29753101
Dilatation atrial 12.24 10.57 36 195732 2083 29754627
Skin tightness 12.20 10.57 35 195733 1997 29754713
Pneumopericardium 12.19 10.57 7 195761 67 29756643
Hypokalaemia 12.14 10.57 243 195525 49949 29706761
Small for dates baby 12.14 10.57 3 195765 3205 29753505
Lipoedema 12.11 10.57 3 195765 0 29756710
Endotracheal intubation complication 12.09 10.57 13 195755 330 29756380
Procedural hypotension 12.07 10.57 23 195745 1002 29755708
Non-cardiac chest pain 12.05 10.57 56 195712 4048 29752662
Hypoalbuminaemia 12.01 10.57 35 195733 11057 29745653
Hyperammonaemia 12.01 10.57 11 195757 5509 29751201
Hypogammaglobulinaemia 12.00 10.57 10 195758 5242 29751468
Immunosuppressant drug level increased 11.97 10.57 8 195760 4694 29752016
Type 2 diabetes mellitus 11.96 10.57 139 195629 13483 29743227
Pain 11.95 10.57 1296 194472 171345 29585365
Gastric cancer 11.84 10.57 9 195759 4941 29751769
Diverticulum 11.83 10.57 80 195688 6653 29750057
Bronchiectasis 11.77 10.57 10 195758 5194 29751516
Myxoedema coma 11.77 10.57 12 195756 286 29756424
Gallbladder oedema 11.74 10.57 10 195758 188 29756522
Atrial septal defect 11.69 10.57 16 195752 6685 29750025
Cardiovascular disorder 11.59 10.57 116 195652 10836 29745874
Diffuse large B-cell lymphoma 11.52 10.57 21 195747 7820 29748890
Stress 11.46 10.57 191 195577 20044 29736666
Subileus 11.46 10.57 3 195765 3084 29753626
Penile swelling 11.45 10.57 20 195748 814 29755896
Brain oedema 11.44 10.57 42 195726 12356 29744354
Therapeutic product effect incomplete 11.43 10.57 154 195614 33680 29723030
Intestinal obstruction 11.41 10.57 76 195692 19136 29737574
Oligohydramnios 11.37 10.57 12 195756 298 29756412
Metabolic acidosis 11.34 10.57 323 195445 37138 29719572
Osteoporosis 11.29 10.57 34 195734 10629 29746081
Maternal drugs affecting foetus 11.24 10.57 7 195761 4266 29752444
Enterococcal infection 11.23 10.57 23 195745 8201 29748509
Pelvic neoplasm 11.20 10.57 4 195764 10 29756700
Sedation 11.18 10.57 62 195706 16311 29740399
Organising pneumonia 11.18 10.57 10 195758 5064 29751646
Weaning failure 11.17 10.57 11 195757 251 29756459
Renal mass 11.14 10.57 28 195740 1476 29755234
Hypoventilation 11.10 10.57 3 195765 3020 29753690
Vomiting projectile 11.00 10.57 17 195751 624 29756086
Pericarditis 10.98 10.57 25 195743 8581 29748129
Anaesthesia 10.95 10.57 6 195762 52 29756658
Haemolysis 10.95 10.57 19 195749 7212 29749498
Raynaud's phenomenon 10.93 10.57 12 195756 312 29756398
Malaise 10.91 10.57 941 194827 166021 29590689
Somnolence 10.88 10.57 519 195249 96244 29660466
Graft versus host disease in skin 10.87 10.57 4 195764 3303 29753407
Acute coronary syndrome 10.83 10.57 136 195632 13437 29743273
Occult blood positive 10.81 10.57 51 195717 3709 29753001
Terminal state 10.81 10.57 5 195763 3599 29753111
Prostatic specific antigen increased 10.77 10.57 123 195645 11881 29744829
Haemoglobin decreased 10.74 10.57 623 195145 113475 29643235
Albumin urine present 10.73 10.57 13 195755 377 29756333
Autoimmune disorder 10.73 10.57 28 195740 1511 29755199
Endometriosis male 10.68 10.57 4 195764 12 29756698
Anaphylactic shock 10.68 10.57 51 195717 13942 29742768
Clostridium difficile infection 10.65 10.57 60 195708 15723 29740987
Blood sodium decreased 10.64 10.57 154 195614 15702 29741008
Liver abscess 10.63 10.57 4 195764 3258 29753452
Diabetic ketoacidosis 10.62 10.57 155 195613 15831 29740879
Diverticulum intestinal haemorrhagic 10.62 10.57 34 195734 2061 29754649
Back pain 10.59 10.57 793 194975 101803 29654907
Lipodystrophy acquired 10.58 10.57 5 195763 3555 29753155

Pharmacologic Action:

SourceCodeDescription
ATC C09AA03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
ATC C09BB03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C10BX07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35674 antihypertensive

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Superficial Ocular Infection indication
Diabetic retinopathy off-label use 4855003 DOID:8947
Atrial fibrillation off-label use 49436004 DOID:0060224
Blepharoconjunctivitis off-label use 68659002 DOID:2456
Dacryocystitis off-label use 85777005 DOID:9938
Corneal ulcer off-label use 91514001 DOID:8463
Diabetic renal disease off-label use 127013003
Bacterial conjunctivitis off-label use 128350005 DOID:9700
Acute scleroderma renal crisis off-label use 236503001
Meibomianitis off-label use 309779001
Infective blepharitis off-label use 312219000
Bacterial keratitis off-label use 314557000
Diastolic heart failure off-label use 418304008 DOID:9775
Nondiabetic Proteinuric Nephropathy off-label use
Migraine Prevention off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Jaundice contraindication 18165001
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Aortic valve stenosis contraindication 60573004 DOID:1712
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Acute hepatic failure contraindication 197270009
Acute pancreatitis contraindication 197456007 DOID:2913
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Disorder of electrolytes contraindication 237840007
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Azotemia contraindication 445009001
Hemodialysis with High-Flux Membrane contraindication
Intestinal Angioedema contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.18 acidic
pKa2 3.18 acidic
pKa3 11.0 Basic
pKa4 6.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 8.92 WOMBAT-PK CHEMBL
Angiotensin-converting enzyme Enzyme Ki 7.29 CHEMBL

External reference:

IDSource
4019380 VUID
N0000147537 NUI
D00362 KEGG_DRUG
83915-83-7 SECONDARY_CAS_RN
4019380 VANDF
C0065374 UMLSCUI
CHEBI:6503 CHEBI
LPR PDB_CHEM_ID
CHEMBL419213 ChEMBL_ID
CHEMBL1237 ChEMBL_ID
CHEMBL1729579 ChEMBL_ID
D017706 MESH_DESCRIPTOR_UI
DB00722 DRUGBANK_ID
6360 IUPHAR_LIGAND_ID
E7199S1YWR UNII
5362119 PUBCHEM_CID
29046 RXNORM
31907 MMSL
44066 MMSL
4985 MMSL
d00732 MMSL
000658 NDDF
108575001 SNOMEDCT_US
341000220102 SNOMEDCT_US
386873009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PRINIVIL HUMAN PRESCRIPTION DRUG LABEL 1 0006-0019 TABLET 5 mg ORAL NDA 27 sections
PRINIVIL HUMAN PRESCRIPTION DRUG LABEL 1 0006-0106 TABLET 10 mg ORAL NDA 27 sections
PRINIVIL HUMAN PRESCRIPTION DRUG LABEL 1 0006-0207 TABLET 20 mg ORAL NDA 27 sections
Lisinopril with Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0143-1262 TABLET 10 mg ORAL ANDA 24 sections
Lisinopril with Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0143-1263 TABLET 20 mg ORAL ANDA 24 sections
Lisinopril with Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0143-1264 TABLET 20 mg ORAL ANDA 24 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-9713 TABLET 20 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-9714 TABLET 10 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-9715 TABLET 5 mg ORAL ANDA 26 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0025 TABLET 2.50 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0101 TABLET 10 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0102 TABLET 20 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0103 TABLET 30 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0104 TABLET 40 mg ORAL ANDA 25 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0185-0152 TABLET 20 mg ORAL ANDA 22 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0185-0173 TABLET 20 mg ORAL ANDA 22 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0602 TABLET 2.50 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0605 TABLET 5 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0610 TABLET 10 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0620 TABLET 20 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0630 TABLET 30 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0640 TABLET 40 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-5400 TABLET 5 mg ORAL ANDA 25 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0185-7100 TABLET 10 mg ORAL ANDA 22 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0440-7674 TABLET 5 mg ORAL ANDA 21 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0405 TABLET 2.50 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0406 TABLET 5 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0407 TABLET 10 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0408 TABLET 20 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0409 TABLET 40 mg ORAL ANDA 26 sections