dihydrocodeine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	886	125-28-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dihydrocodeine codhydrine cohydrin dehacodin dihydroneopine hydrocodeine hydrocodin dihydrocodeine bitartrate parzone bitartrate dihydrocodeine phosphate	Molecular weight: 301.39 Formula: C18H23NO3 CLOGP: 1.26 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 41.93 ALOGS: -2.10 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dihydrocodeine
codhydrine
cohydrin
dehacodin
dihydroneopine
hydrocodeine
hydrocodin
dihydrocodeine bitartrate
parzone bitartrate
dihydrocodeine phosphate

Molecular weight: 301.39
Formula: C18H23NO3
CLOGP: 1.26
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 41.93
ALOGS: -2.10
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

Show entries

Search:

Property	Value	Reference
CL (Clearance)	4.21 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	3.42 hours	Lombardo F, Berellini G, Obach RS
S (Water solubility)	222 mg/mL	Bocci G, Oprea TI, Benet LZ
BA (Bioavailability)	20 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	1.07 L/kg	Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Showing 1 to 6 of 6 entries

Previous1Next

Approvals:

Date	Agency	Company	Orphan
July 7, 1958	FDA	CARACO

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Congenital thrombocytopenia	77.78	26.55	11	3301	55	63485655
Toxicity to various agents	72.30	26.55	76	3236	247174	63238536
Acute kidney injury	71.80	26.55	78	3234	263337	63222373
Neutropenic sepsis	56.90	26.55	24	3288	16414	63469296
Intestinal pseudo-obstruction	48.94	26.55	11	3301	901	63484809
Abdominal pain	47.63	26.55	67	3245	293389	63192321
Perforation	46.10	26.55	11	3301	1172	63484538
Toxic leukoencephalopathy	45.48	26.55	10	3302	741	63484969
Overflow diarrhoea	42.03	26.55	7	3305	115	63485595
Hydronephrosis	41.73	26.55	17	3295	10645	63475065

Showing 1 to 10 of 23 entries

Previous1 2 3Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	95.59	23.45	89	2206	200273	34754363
Autoscopy	53.89	23.45	10	2285	247	34954389
Overdose	44.19	23.45	41	2254	91018	34863618
Femoral nerve palsy	37.79	23.45	6	2289	56	34954580
Upper gastrointestinal haemorrhage	26.47	23.45	18	2277	25500	34929136
Electric shock sensation	26.33	23.45	5	2290	140	34954496
Tandem gait test abnormal	25.63	23.45	4	2291	33	34954603
Alcoholic liver disease	24.12	23.45	6	2289	602	34954034
Genital herpes	23.87	23.45	6	2289	629	34954007

Showing 1 to 9 of 9 entries

Previous1Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	129.52	21.38	152	5364	421388	79317484
Acute kidney injury	54.12	21.38	114	5402	519290	79219582
Neutropenic sepsis	41.72	21.38	25	5491	27039	79711833
Abnormal loss of weight	41.05	21.38	17	5499	8359	79730513
Perforation	40.97	21.38	11	5505	1415	79737457
Overdose	39.82	21.38	56	5460	184150	79554722
Toxic leukoencephalopathy	38.39	21.38	10	5506	1144	79737728
Overflow diarrhoea	37.66	21.38	7	5509	165	79738707
Abdominal pain	37.61	21.38	83	5433	389486	79349386
Femoral nerve palsy	35.44	21.38	6	5510	81	79738791

Showing 1 to 10 of 29 entries

Previous1 2 3Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	N02AA08	NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids
ATC	N02AA58	NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids
ATC	N02AJ01	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
ATC	N02AJ02	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
ATC	N02AJ03	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
FDA EPC	N0000175690	Opioid Agonist
FDA MoA	N0000175684	Full Opioid Agonists
MeSH PA	D000700	Analgesics
MeSH PA	D000701	Analgesics, Opioid
MeSH PA	D002491	Central Nervous System Agents

Showing 1 to 10 of 14 entries

Previous1 2Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Pain	indication	22253000
Cough	indication	49727002
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Rhinitis	indication	70076002	DOID:4483
Common cold	indication	82272006	DOID:10459
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Ocular hypertension	contraindication	4210003	DOID:9282
Suicidal thoughts	contraindication	6471006

Showing 1 to 10 of 98 entries

Previous1 2 3 4 5…10Next

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.22	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN	AGONIST				CHEMBL	CHEMBL

Showing 1 to 1 of 1 entries

Previous1Next

External reference:

Show entries

Search:

ID	Source
001557	NDDF
004420	NDDF
004421	NDDF
104966	RXNORM
24204-13-5	SECONDARY_CAS_RN
322538006	SNOMEDCT_US
387322000	SNOMEDCT_US
4018062	VANDF
4019720	VUID
4019720	VANDF

Showing 1 to 10 of 26 entries

Previous1 2 3Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Acetaminophen, Caffeine and Dihydrocodeine Bitartrate	HUMAN PRESCRIPTION DRUG LABEL	3	71993-300	TABLET	16 mg	ORAL	ANDA	27 sections
Acetaminophen, Caffeine, Dihydrocodeine Bitartrate	HUMAN PRESCRIPTION DRUG LABEL	3	42195-840	CAPSULE	16 mg	ORAL	ANDA	28 sections
Dihydrocodeine Bitartrate, Acetaminophen and Caffeine	HUMAN PRESCRIPTION DRUG LABEL	3	54868-5900	TABLET	32 mg	ORAL	ANDA	20 sections
Trezix	HUMAN PRESCRIPTION DRUG LABEL	3	63187-705	CAPSULE	16 mg	ORAL	ANDA	22 sections
Trezix	HUMAN PRESCRIPTION DRUG LABEL	3	63187-705	CAPSULE	16 mg	ORAL	ANDA	22 sections
Trezix	HUMAN PRESCRIPTION DRUG LABEL	3	63629-5637	CAPSULE	16 mg	ORAL	ANDA	22 sections
Trezix	HUMAN PRESCRIPTION DRUG LABEL	3	66992-840	CAPSULE	16 mg	ORAL	ANDA	23 sections

Showing 1 to 7 of 7 entries

Previous1Next