epinephrine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 1028 51-43-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • epinephrine
  • vasoconstrictine
  • nephridine
  • renoform
  • suprarenin
  • epinephrine bitartrate
  • (-)-adrenaline
  • epinephrine hydrochloride
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
  • Molecular weight: 183.21
  • Formula: C9H13NO3
  • CLOGP: -0.68
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -0.99
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.50 mg P
2.24 mg Inhal.aerosol
20 mg Inhal.solution

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.09 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
S (Water solubility) 0.18 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Nov. 19, 1948 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sinusitis 903.90 9.70 1687 134438 224966 63127931
Hereditary angioedema 618.31 9.70 309 135816 7253 63345644
Local anaesthetic systemic toxicity 500.82 9.70 149 135976 750 63352147
Stress cardiomyopathy 491.64 9.70 286 135839 9164 63343733
Anaphylactic reaction 433.16 9.70 617 135508 65483 63287414
Infusion site pain 416.29 9.70 321 135804 16548 63336349
Contraindicated product administered 378.18 9.70 22 136103 217626 63135271
Device failure 372.43 9.70 204 135921 5807 63347090
Infusion site swelling 361.52 9.70 238 135887 9532 63343365
Pemphigus 355.30 9.70 8 136117 183718 63169179
Toxic anterior segment syndrome 336.72 9.70 131 135994 1640 63351257
Infusion site erythema 323.13 9.70 238 135887 11441 63341456
Drug intolerance 316.41 9.70 133 135992 308528 63044369
Anaesthetic complication 313.56 9.70 128 135997 1832 63351065
Infusion site extravasation 307.84 9.70 221 135904 10205 63342692
Hand deformity 304.26 9.70 8 136117 159449 63193448
COVID-19 297.11 9.70 711 135414 112392 63240505
Glossodynia 296.28 9.70 23 136102 178853 63174044
Joint swelling 283.94 9.70 176 135949 327490 63025407
Bronchitis 281.66 9.70 741 135384 124194 63228703
Synovitis 278.50 9.70 36 136089 186882 63166015
Kounis syndrome 270.01 9.70 111 136014 1619 63351278
Infusion site pruritus 268.06 9.70 165 135960 5870 63347027
Cardiac arrest 244.32 9.70 583 135542 91962 63260935
Upper respiratory tract infection 234.23 9.70 533 135592 81514 63271383
Systemic lupus erythematosus 234.10 9.70 78 136047 208840 63144057
Anti-cyclic citrullinated peptide antibody positive 233.13 9.70 3 136122 116209 63236688
Alopecia 226.39 9.70 234 135891 337302 63015595
Anaphylactic shock 217.66 9.70 261 135864 23372 63329525
Arthropathy 214.77 9.70 118 136007 234674 63118223
Accidental exposure to product 214.56 9.70 279 135846 27126 63325771
Ear infection 202.23 9.70 323 135802 37890 63315007
Infusion site haemorrhage 198.20 9.70 128 135997 4958 63347939
Hepatic enzyme increased 198.01 9.70 93 136032 202235 63150662
Seasonal allergy 189.06 9.70 229 135896 20721 63332176
Wound 188.10 9.70 58 136067 163205 63189692
Pericarditis 187.38 9.70 29 136096 131550 63221347
Illness 178.59 9.70 352 135773 48707 63304190
Chondrolysis 177.48 9.70 49 136076 178 63352719
Infusion site bruising 173.33 9.70 106 136019 3726 63349171
Completed suicide 172.83 9.70 49 136076 145624 63207273
Therapeutic product effect decreased 172.45 9.70 100 136025 193087 63159810
Rheumatoid arthritis 172.30 9.70 174 135951 253645 63099252
Rheumatoid factor positive 165.79 9.70 3 136122 84403 63268494
Abdominal discomfort 158.71 9.70 278 135847 320607 63032290
Insurance issue 156.52 9.70 119 136006 6002 63346895
Respiratory tract infection 151.42 9.70 298 135827 41185 63311712
Pulseless electrical activity 149.21 9.70 126 135999 7395 63345502
General physical health deterioration 144.90 9.70 131 135994 201271 63151626
Treatment failure 143.75 9.70 129 135996 198914 63153983
Maternal exposure during delivery 136.65 9.70 66 136059 1434 63351463
Impaired quality of life 134.82 9.70 157 135968 13626 63339271
Bradycardia 132.24 9.70 401 135724 72826 63280071
Product dose omission issue 130.05 9.70 904 135221 233409 63119488
Headache 125.81 9.70 1979 134146 631262 62721635
Incorrect drug administration rate 121.60 9.70 86 136039 3876 63349021
Lagophthalmos 121.55 9.70 41 136084 329 63352568
Folliculitis 119.35 9.70 8 136117 70309 63282588
Helicobacter infection 116.14 9.70 28 136097 92757 63260140
Ventricular tachycardia 112.79 9.70 174 135951 19805 63333092
Hypotension 111.55 9.70 980 135145 271624 63081273
Urticaria 110.49 9.70 670 135455 165132 63187765
Infusion site mass 105.99 9.70 62 136063 2006 63350891
Corneal oedema 104.62 9.70 55 136070 1438 63351459
Product quality issue 103.40 9.70 234 135891 35631 63317266
Inappropriate schedule of product administration 102.99 9.70 469 135656 103496 63249401
Infusion site nodule 101.82 9.70 54 136071 1438 63351459
Asthma 101.79 9.70 541 135584 127020 63225877
Muscle injury 101.18 9.70 11 136114 65334 63287563
Administration site swelling 99.78 9.70 51 136074 1256 63351641
Arthralgia 97.87 9.70 768 135357 568942 62783955
Urinary tract infection 92.93 9.70 921 135204 263763 63089134
Impaired healing 91.56 9.70 53 136072 102489 63250408
Musculoskeletal stiffness 87.53 9.70 164 135961 184454 63168443
Bronchospasm 87.23 9.70 143 135982 17137 63335760
Psoriatic arthropathy 86.53 9.70 44 136081 91476 63261421
Cardiogenic shock 83.33 9.70 143 135982 17789 63335108
Infusion site rash 82.20 9.70 52 136073 1942 63350955
Fear 81.65 9.70 132 135993 15634 63337263
Endophthalmitis 81.36 9.70 65 136060 3527 63349370
Diarrhoea 80.76 9.70 1066 135059 714300 62638597
Liver injury 80.32 9.70 16 136109 60504 63292393
Rheumatic fever 79.18 9.70 3 136122 43108 63309789
Multiple allergies 79.02 9.70 121 136004 13681 63339216
Migraine 76.83 9.70 430 135695 102916 63249981
Stridor 76.28 9.70 62 136063 3448 63349449
Incorrect route of product administration 75.69 9.70 176 135949 27276 63325621
Liquid product physical issue 75.67 9.70 41 136084 1141 63351756
Left ventricle outflow tract obstruction 74.90 9.70 27 136098 269 63352628
Discomfort 74.74 9.70 154 135971 167220 63185677
Injection site ischaemia 74.48 9.70 15 136110 3 63352894
Infusion site urticaria 74.37 9.70 45 136080 1551 63351346
Anhedonia 74.11 9.70 104 136021 10870 63342027
Needle issue 74.07 9.70 101 136024 10275 63342622
Ventricular fibrillation 73.60 9.70 108 136017 11759 63341138
Methaemoglobinaemia 73.38 9.70 52 136073 2351 63350546
Cauda equina syndrome 73.32 9.70 38 136087 964 63351933
Neutropenia 72.38 9.70 168 135957 174837 63178060
Shock 72.03 9.70 157 135968 23306 63329591
Swelling 71.06 9.70 326 135799 275052 63077845
Administration site pain 70.10 9.70 35 136090 819 63352078
Blister 69.15 9.70 107 136018 129707 63223190
Renal injury 69.09 9.70 93 136032 9346 63343551
Injury associated with device 67.80 9.70 59 136066 3607 63349290
Stomatitis 66.83 9.70 122 136003 138603 63214294
Electrocardiogram ST segment elevation 66.26 9.70 60 136065 3867 63349030
C-reactive protein abnormal 65.95 9.70 10 136115 46086 63306811
Tachycardia 65.51 9.70 456 135669 117700 63235197
Body tinea 65.10 9.70 44 136081 1841 63351056
Unevaluable event 65.09 9.70 250 135875 51136 63301761
Expired product administered 64.82 9.70 73 136052 6108 63346789
Infusion site irritation 64.43 9.70 34 136091 896 63352001
Injection site pallor 64.30 9.70 17 136108 50 63352847
Acute kidney injury 63.78 9.70 319 135806 263096 63089801
Generalised tonic-clonic seizure 63.15 9.70 170 135955 28846 63324051
Product use issue 61.79 9.70 253 135872 220267 63132630
Dermatitis contact 60.91 9.70 95 136030 10913 63341984
Pulse absent 60.73 9.70 66 136059 5308 63347589
Lower respiratory tract infection 60.53 9.70 120 136005 132187 63220710
COVID-19 immunisation 60.02 9.70 41 136084 1746 63351151
Kidney infection 60.01 9.70 145 135980 23031 63329866
Hyponatraemia 59.82 9.70 92 136033 111808 63241089
Staphylococcal infection 59.21 9.70 209 135916 41047 63311850
Anaesthetic complication neurological 59.09 9.70 22 136103 242 63352655
Arteriospasm coronary 58.04 9.70 56 136069 3912 63348985
Confusional state 57.93 9.70 285 135840 236095 63116802
Airway peak pressure increased 56.72 9.70 22 136103 273 63352624
Fungal infection 56.58 9.70 191 135934 36683 63316214
Mobility decreased 55.33 9.70 110 136015 121049 63231848
Eye infection 55.31 9.70 96 136029 12049 63340848
Peripheral ischaemia 55.28 9.70 60 136065 4818 63348079
Systemic toxicity 54.88 9.70 16 136109 74 63352823
Post procedural complication 54.42 9.70 116 136009 16958 63335939
Hypopyon 54.25 9.70 28 136097 704 63352193
Blood cholesterol increased 53.50 9.70 74 136051 93958 63258939
Blood pressure decreased 53.36 9.70 278 135847 64744 63288153
Administration site erythema 53.09 9.70 28 136097 737 63352160
Angioedema 51.72 9.70 222 135903 47743 63305154
Gastroenteritis viral 51.72 9.70 139 135986 23561 63329336
Type 2 diabetes mellitus 51.56 9.70 37 136088 63831 63289066
Chills 50.70 9.70 416 135709 112962 63239935
Electrocardiogram ST segment depression 50.60 9.70 45 136080 2832 63350065
Infusion site discomfort 50.53 9.70 34 136091 1412 63351485
Decreased appetite 49.97 9.70 324 135801 250728 63102169
Sinus disorder 49.61 9.70 140 135985 24413 63328484
Haemodynamic instability 49.04 9.70 78 136047 9112 63343785
Inhibitory drug interaction 48.99 9.70 44 136081 2805 63350092
Cataract operation complication 47.92 9.70 16 136109 124 63352773
Tryptase increased 47.90 9.70 21 136104 362 63352535
Extradural abscess 47.78 9.70 28 136097 909 63351988
Peripheral swelling 46.67 9.70 356 135769 265586 63087311
Poor venous access 46.60 9.70 100 136025 14685 63338212
Seizure 46.20 9.70 461 135664 132173 63220724
Disease progression 45.95 9.70 124 136001 122634 63230263
Irritable bowel syndrome 45.75 9.70 66 136059 82346 63270551
Vasoplegia syndrome 45.59 9.70 34 136091 1665 63351232
Ventricular hypokinesia 45.58 9.70 53 136072 4591 63348306
C-reactive protein increased 44.97 9.70 84 136041 94623 63258274
Infection susceptibility increased 44.69 9.70 46 136079 3475 63349422
Pharyngitis streptococcal 44.29 9.70 81 136044 10591 63342306
Wrong product administered 44.17 9.70 60 136065 6081 63346816
Anaemia 43.76 9.70 410 135715 293020 63059877
Immunisation reaction 43.55 9.70 23 136102 607 63352290
Skin infection 43.36 9.70 98 136027 14904 63337993
Intentional self-injury 43.35 9.70 3 136122 25684 63327213
Swollen tongue 43.00 9.70 168 135957 34632 63318265
Cystitis 42.98 9.70 232 135893 54759 63298138
Myocardial ischaemia 42.88 9.70 89 136036 12770 63340127
Emotional distress 42.57 9.70 160 135965 32389 63320508
Infusion site reaction 42.20 9.70 45 136080 3542 63349355
Procedural hypotension 41.63 9.70 28 136097 1162 63351735
Malignant neoplasm progression 41.55 9.70 70 136055 82051 63270846
Accidental overdose 41.44 9.70 127 135998 23182 63329715
Purtscher retinopathy 40.84 9.70 13 136112 85 63352812
Blood creatinine increased 40.75 9.70 79 136046 87765 63265132
Stress 40.06 9.70 264 135861 66903 63285994
Pancytopenia 39.30 9.70 94 136031 96839 63256058
Sinus tachycardia 39.28 9.70 128 135997 24140 63328757
Chest discomfort 39.15 9.70 384 135741 109585 63243312
Prescribed underdose 39.07 9.70 8 136117 29681 63323216
Pharyngeal oedema 38.96 9.70 89 136036 13632 63339265
Lip swelling 38.41 9.70 150 135975 30913 63321984
Status asthmaticus 38.33 9.70 24 136101 880 63352017
Thrombocytopenia 38.32 9.70 180 135945 150977 63201920
Dermatitis atopic 38.09 9.70 72 136053 9652 63343245
Hip arthroplasty 37.94 9.70 28 136097 47618 63305279
Procedural complication 37.41 9.70 52 136073 5387 63347510
Drug ineffective for unapproved indication 36.99 9.70 158 135967 33905 63318992
Influenza 36.94 9.70 376 135749 108346 63244551
Viral infection 36.87 9.70 163 135962 35500 63317397
Pulmonary oedema 36.65 9.70 222 135903 54651 63298246
Extradural haematoma 36.55 9.70 30 136095 1692 63351205
Hypoaesthesia oral 36.41 9.70 84 136041 12949 63339948
Hyperaesthesia 36.30 9.70 69 136056 9289 63343608
Vitritis 36.29 9.70 24 136101 968 63351929
Circulatory collapse 35.76 9.70 116 136009 21822 63331075
Asthenia 35.69 9.70 593 135532 383011 62969886
Drug reaction with eosinophilia and systemic symptoms 35.53 9.70 14 136111 33822 63319075
Infusion site warmth 35.12 9.70 30 136095 1788 63351109
Condition aggravated 35.09 9.70 629 135496 401588 62951309
Tooth infection 35.05 9.70 101 136024 17819 63335078
Limb injury 34.79 9.70 127 135998 25350 63327547
Throat tightness 34.79 9.70 125 136000 24762 63328135
Administration site pruritus 34.65 9.70 16 136109 313 63352584
Mydriasis 34.44 9.70 78 136047 11878 63341019
Paraplegia 34.08 9.70 35 136090 2637 63350260
Glucose tolerance impaired 33.97 9.70 55 136070 6522 63346375
Pharyngeal swelling 33.68 9.70 54 136071 6350 63346547
Administration site bruise 33.62 9.70 17 136108 409 63352488
Abortion spontaneous 33.53 9.70 31 136094 47164 63305733
Death 33.44 9.70 583 135542 373798 62979099
Liver function test abnormal 32.66 9.70 33 136092 48148 63304749
Laryngeal oedema 32.55 9.70 50 136075 5668 63347229
Anaphylactoid reaction 32.45 9.70 40 136085 3683 63349214
Platelet aggregation inhibition 32.40 9.70 12 136113 130 63352767
Abdominal pain upper 32.25 9.70 285 135840 206159 63146738
Inability to afford medication 32.23 9.70 32 136093 2315 63350582
Nerve root injury 32.12 9.70 9 136116 35 63352862
Administration site reaction 31.95 9.70 14 136111 241 63352656
Troponin I increased 31.64 9.70 31 136094 2207 63350690
Injection site injury 31.61 9.70 19 136106 647 63352250
Unresponsive to stimuli 31.58 9.70 150 135975 33666 63319231
Type I hypersensitivity 31.29 9.70 35 136090 2907 63349990
Cholestasis 31.20 9.70 12 136113 29422 63323475
Adverse event 31.12 9.70 61 136064 67498 63285399
Embolia cutis medicamentosa 30.69 9.70 16 136109 411 63352486
Product contamination microbial 30.64 9.70 13 136112 206 63352691
Leukopenia 30.50 9.70 76 136049 77214 63275683
Musculoskeletal pain 30.34 9.70 99 136026 92178 63260719
Loss of personal independence in daily activities 30.20 9.70 107 136018 97183 63255714
Ophthalmoplegia 30.02 9.70 25 136100 1439 63351458
Liver disorder 29.79 9.70 43 136082 53644 63299253
Uterine hypertonus 29.77 9.70 14 136111 286 63352611
Anterior chamber cell 29.72 9.70 17 136108 527 63352370
Drug abuse 29.65 9.70 70 136055 72448 63280449
Pneumocephalus 29.63 9.70 12 136113 168 63352729
Infusion site discolouration 29.59 9.70 20 136105 837 63352060
Infusion site induration 29.58 9.70 23 136102 1199 63351698
Ill-defined disorder 29.53 9.70 84 136041 81671 63271226
Knee arthroplasty 29.50 9.70 44 136081 54162 63298735
Poor quality sleep 29.47 9.70 102 136023 19833 63333064
Injection site coldness 28.84 9.70 10 136115 88 63352809
Phrenic nerve paralysis 28.64 9.70 12 136113 184 63352713
Drug resistance 28.53 9.70 7 136118 22926 63329971
White blood cell count decreased 28.43 9.70 178 135947 138926 63213971
Injection site hypoaesthesia 28.41 9.70 16 136109 481 63352416
Anxiety 28.38 9.70 638 135487 216903 63135994
Inflammation 27.93 9.70 87 136038 82186 63270711
Paralysis 27.87 9.70 64 136061 9836 63343061
Red blood cell sedimentation rate increased 27.73 9.70 32 136093 43950 63308947
Administration site extravasation 27.44 9.70 20 136105 945 63351952
PO2 decreased 27.37 9.70 24 136101 1482 63351415
Foetal exposure during delivery 27.23 9.70 11 136114 153 63352744
Aqueous fibrin 27.15 9.70 9 136116 68 63352829
Neuromuscular block prolonged 27.12 9.70 16 136109 526 63352371
Bladder prolapse 27.06 9.70 28 136097 2128 63350769
Removal of foreign body 26.93 9.70 8 136117 40 63352857
Vasospasm 26.83 9.70 18 136107 744 63352153
Oral herpes 26.82 9.70 119 136006 25955 63326942
Psoriasis 26.75 9.70 96 136029 86861 63266036
Blood pressure increased 26.66 9.70 492 135633 161570 63191327
Device infusion issue 26.54 9.70 27 136098 2011 63350886
Fear of eating 26.22 9.70 14 136111 378 63352519
Blood pH decreased 26.19 9.70 30 136095 2557 63350340
Influenza like illness 26.09 9.70 238 135887 66586 63286311
Therapeutic product effect incomplete 26.09 9.70 159 135966 124897 63228000
Gas gangrene 25.93 9.70 10 136115 122 63352775
Bursitis infective 25.62 9.70 22 136103 1321 63351576
Hepatotoxicity 25.53 9.70 25 136100 37016 63315881
Orthostatic hypotension 25.40 9.70 24 136101 36136 63316761
Anaphylactoid shock 25.29 9.70 13 136112 324 63352573
Abdominal pain 25.22 9.70 460 135665 292996 63059901
Osteonecrosis of jaw 25.04 9.70 23 136102 35100 63317797
Apnoea 24.99 9.70 54 136071 7968 63344929
Corneal epithelium defect 24.76 9.70 13 136112 339 63352558
Normal newborn 24.68 9.70 55 136070 8286 63344611
Product distribution issue 24.61 9.70 22 136103 1394 63351503
Cyanosis 24.47 9.70 86 136039 16849 63336048
Meningitis aseptic 24.46 9.70 40 136085 4783 63348114
Peripheral nerve injury 24.39 9.70 14 136111 437 63352460
Spinal stroke 24.08 9.70 7 136118 32 63352865
Cardiac failure congestive 24.05 9.70 109 136016 92324 63260573
Food allergy 24.01 9.70 66 136059 11335 63341562
Axillary nerve injury 24.00 9.70 6 136119 13 63352884
Tracheal deviation 23.95 9.70 10 136115 152 63352745
Meningitis chemical 23.83 9.70 10 136115 154 63352743
Product adhesion issue 23.74 9.70 39 136086 4680 63348217
Eyelid rash 23.71 9.70 10 136115 156 63352741
Device expulsion 23.58 9.70 24 136101 34898 63317999
Upper airway obstruction 23.31 9.70 16 136109 687 63352210
Metabolic acidosis 23.25 9.70 171 135954 44898 63307999
Mast cell activation syndrome 23.24 9.70 17 136108 808 63352089
Ventricular extrasystoles 22.98 9.70 66 136059 11621 63341276
Pulmonary fibrosis 22.97 9.70 31 136094 39778 63313119
Inappropriate antidiuretic hormone secretion 22.95 9.70 3 136122 15459 63337438
Impaired work ability 22.93 9.70 86 136039 17389 63335508
Parophthalmia 22.92 9.70 12 136113 311 63352586
Sinus operation 22.89 9.70 28 136097 2558 63350339
Respiratory depression 22.79 9.70 73 136052 13642 63339255
Spinal operation 22.76 9.70 53 136072 8218 63344679
Eye inflammation 22.61 9.70 42 136083 5557 63347340
Neonatal toxicity 22.60 9.70 6 136119 18 63352879
Infusion site scar 22.44 9.70 14 136111 510 63352387
Drug tolerance decreased 22.40 9.70 5 136120 17468 63335429
Creatinine renal clearance decreased 22.30 9.70 4 136121 16304 63336593
Myopathy toxic 22.29 9.70 14 136111 516 63352381
Interstitial lung disease 22.07 9.70 64 136061 61844 63291053
Gastrointestinal disorder 21.91 9.70 178 135947 131061 63221836
Cranial nerve palsies multiple 21.90 9.70 6 136119 21 63352876
Respiratory acidosis 21.83 9.70 46 136079 6669 63346228
Respiratory distress 21.81 9.70 136 135989 33815 63319082
Rectal prolapse 21.79 9.70 24 136101 1959 63350938
Retinal artery occlusion 21.71 9.70 22 136103 1631 63351266
Trigemino-cardiac reflex 21.70 9.70 7 136118 48 63352849
Constipation 21.45 9.70 346 135779 224597 63128300
Bundle branch block left 21.40 9.70 47 136078 7012 63345885
Rash 21.36 9.70 984 135141 559887 62793010
Loss of consciousness 21.34 9.70 364 135761 117757 63235140
Hypopnoea 21.27 9.70 33 136092 3773 63349124
Animal bite 21.24 9.70 29 136096 2953 63349944
Septic arthritis staphylococcal 21.18 9.70 13 136112 460 63352437
Ventricular arrhythmia 21.13 9.70 33 136092 3795 63349102
Catarrh 21.05 9.70 21 136104 1528 63351369
PCO2 increased 21.04 9.70 19 136106 1220 63351677
Jaundice 21.03 9.70 19 136106 29232 63323665
Bone erosion 20.92 9.70 6 136119 17711 63335186
Vitamin D increased 20.80 9.70 15 136110 697 63352200
Retinal vasculitis 20.74 9.70 17 136108 957 63351940
Hepatocellular injury 20.64 9.70 17 136108 27364 63325533
Eyelid ptosis 20.48 9.70 47 136078 7220 63345677
Arterial spasm 20.45 9.70 7 136118 59 63352838
Spinal epidural haemorrhage 20.43 9.70 8 136117 102 63352795
Administration site haemorrhage 20.29 9.70 8 136117 104 63352793
Injection site discharge 20.19 9.70 16 136109 858 63352039
Gait inability 20.18 9.70 53 136072 52906 63299991
Cellulitis 20.03 9.70 266 135859 81692 63271205
Anal skin tags 19.98 9.70 13 136112 510 63352387
Injection site pain 19.95 9.70 390 135735 129410 63223487
Postresuscitation encephalopathy 19.94 9.70 5 136120 11 63352886
Vaccination complication 19.89 9.70 18 136107 1159 63351738
Catheter site pain 19.73 9.70 36 136089 4699 63348198
Fear of death 19.66 9.70 17 136108 1030 63351867
Injection site inflammation 19.66 9.70 32 136093 3811 63349086
Device ineffective 19.65 9.70 10 136115 244 63352653
No adverse event 19.62 9.70 154 135971 41251 63311646
Oedema peripheral 19.60 9.70 287 135838 189224 63163673
Alanine aminotransferase increased 19.58 9.70 136 135989 103634 63249263
Product availability issue 19.32 9.70 33 136092 4088 63348809
Bacterial infection 19.31 9.70 88 136037 19411 63333486
Status epilepticus 19.19 9.70 74 136051 15159 63337738
Administration site nodule 19.15 9.70 6 136119 37 63352860
Blood lactic acid increased 19.06 9.70 45 136080 7041 63345856
Administration site irritation 19.01 9.70 6 136119 38 63352859
Troponin T increased 18.91 9.70 18 136107 1236 63351661
Steroid dependence 18.78 9.70 21 136104 1743 63351154
Heart rate increased 18.73 9.70 295 135830 93943 63258954
Lip dry 18.71 9.70 5 136120 15465 63337432
Metastases to liver 18.68 9.70 14 136111 23625 63329272
Obesity 18.66 9.70 22 136103 29930 63322967
Gastrointestinal haemorrhage 18.65 9.70 100 136025 81076 63271821
Local reaction 18.60 9.70 14 136111 695 63352202
Muscle tightness 18.57 9.70 62 136063 11838 63341059
Extremity necrosis 18.56 9.70 20 136105 1593 63351304
Electrocardiogram QRS complex prolonged 18.53 9.70 40 136085 5898 63346999
Hypercalcaemia 18.52 9.70 20 136105 28302 63324595
Harlequin syndrome 18.50 9.70 6 136119 42 63352855
Spinal anaesthesia 18.50 9.70 6 136119 42 63352855
Burns second degree 18.46 9.70 22 136103 1956 63350941
Lung hyperinflation 18.42 9.70 18 136107 1277 63351620
Nystagmus 18.39 9.70 41 136084 6179 63346718
Atonic urinary bladder 18.33 9.70 7 136118 83 63352814
Pneumonia 18.32 9.70 1174 134951 455593 62897304
Nasopharyngitis 18.29 9.70 692 135433 253565 63099332
Platelet count decreased 18.26 9.70 160 135965 115962 63236935
Scar 18.23 9.70 68 136057 13714 63339183
Off label use 18.19 9.70 1224 134901 673238 62679659
Apnoeic attack 18.18 9.70 10 136115 287 63352610
International normalised ratio increased 18.04 9.70 46 136079 46379 63306518
Electrocardiogram T wave inversion 17.83 9.70 29 136096 3452 63349445
Product use in unapproved indication 17.67 9.70 506 135619 178574 63174323
Post procedural infection 17.64 9.70 52 136073 9290 63343607
Nasal discharge discolouration 17.58 9.70 23 136102 2248 63350649
Administration site discolouration 17.49 9.70 6 136119 51 63352846
Nerve block 17.39 9.70 14 136111 768 63352129
Multiple organ dysfunction syndrome 17.27 9.70 192 135933 56560 63296337
Mean arterial pressure decreased 17.17 9.70 8 136117 160 63352737
Drug-induced liver injury 17.11 9.70 38 136087 40184 63312713
Brain injury 17.10 9.70 43 136082 7000 63345897
Neurogenic shock 17.08 9.70 10 136115 324 63352573
Disease recurrence 17.02 9.70 21 136104 28009 63324888
Enzyme induction 16.99 9.70 6 136119 56 63352841
Product contamination physical 16.91 9.70 7 136118 104 63352793
Gastrointestinal infection 16.90 9.70 51 136074 9230 63343667
Gait disturbance 16.72 9.70 284 135841 182894 63170003
Systolic anterior motion of mitral valve 16.67 9.70 5 136120 26 63352871
Product measured potency issue 16.67 9.70 7 136118 108 63352789
Arthropod bite 16.61 9.70 46 136079 7932 63344965
Hepatitis 16.59 9.70 38 136087 39750 63313147
Transaminases increased 16.55 9.70 26 136099 31341 63321556
Conjunctival oedema 16.53 9.70 13 136112 689 63352208
Osteoarthritis 16.52 9.70 128 135997 95215 63257682
Femur fracture 16.52 9.70 41 136084 41715 63311182
Dental restoration failure 16.49 9.70 15 136110 972 63351925
Spinal cord infarction 16.46 9.70 9 136116 255 63352642
Therapeutic product effect prolonged 16.41 9.70 10 136115 349 63352548
Infusion site oedema 16.38 9.70 14 136111 835 63352062
Reversible cerebral vasoconstriction syndrome 16.21 9.70 24 136101 2634 63350263
Vasoconstriction 16.16 9.70 12 136113 584 63352313
Hypocalcaemia 16.06 9.70 27 136098 31686 63321211
ECG signs of myocardial ischaemia 15.96 9.70 6 136119 68 63352829
Oropharyngeal discomfort 15.92 9.70 35 136090 5225 63347672
Accidental exposure to product by child 15.89 9.70 16 136109 1177 63351720
Ischaemia 15.88 9.70 33 136092 4739 63348158
Joint stiffness 15.88 9.70 42 136083 41827 63311070
Streptococcal infection 15.84 9.70 37 136088 5750 63347147
Rhinitis 15.81 9.70 57 136068 11309 63341588
Punctate keratitis 15.72 9.70 12 136113 609 63352288
Product contamination 15.63 9.70 13 136112 747 63352150
Injury 15.59 9.70 232 135893 73015 63279882
Depressed mood 15.48 9.70 40 136085 40151 63312746
Grip strength decreased 15.41 9.70 15 136110 22272 63330625
Vitamin B1 decreased 15.40 9.70 8 136117 204 63352693
Neutropenic sepsis 15.38 9.70 8 136117 16430 63336467
Glossoptosis 15.36 9.70 6 136119 76 63352821
Pneumonia mycoplasmal 15.34 9.70 14 136111 911 63351986
Supraventricular tachycardia 15.34 9.70 66 136059 14205 63338692
Systolic dysfunction 15.28 9.70 18 136107 1581 63351316
Central venous catheterisation 15.18 9.70 23 136102 2576 63350321
Gastric infection 15.15 9.70 27 136098 3460 63349437
Device issue 15.11 9.70 95 136030 23686 63329211
Blood bilirubin increased 15.06 9.70 36 136089 37104 63315793
Neoplasm progression 15.02 9.70 35 136090 36393 63316504
Cognitive disorder 15.01 9.70 65 136060 55750 63297147
Urticaria chronic 14.99 9.70 12 136113 653 63352244
Eosinophilia 14.96 9.70 16 136109 22740 63330157
Mania 14.95 9.70 4 136121 12363 63340534
Postural orthostatic tachycardia syndrome 14.86 9.70 16 136109 1273 63351624
Blood calcium decreased 14.85 9.70 21 136104 26430 63326467
Eye infarction 14.84 9.70 5 136120 40 63352857
Sensory loss 14.80 9.70 52 136073 10186 63342711
Balance disorder 14.78 9.70 113 136012 84309 63268588
Infected bite 14.76 9.70 20 136105 2022 63350875
Cold sweat 14.75 9.70 58 136067 11989 63340908
Vocal cord dysfunction 14.62 9.70 11 136114 546 63352351
Propofol infusion syndrome 14.62 9.70 14 136111 969 63351928
Meningitis 14.57 9.70 41 136084 7136 63345761
Hepatic cirrhosis 14.53 9.70 19 136106 24715 63328182
Maternal exposure during pregnancy 14.49 9.70 360 135765 219702 63133195
Anion gap increased 14.48 9.70 19 136106 1863 63351034
Therapy interrupted 14.45 9.70 119 136006 32336 63320561
Oral pruritus 14.42 9.70 21 136104 2270 63350627
Neuroleptic malignant syndrome 14.39 9.70 4 136121 12052 63340845
Sleep disorder 14.37 9.70 109 136016 81457 63271440
Arachnoiditis 14.30 9.70 9 136116 333 63352564
Arthritis bacterial 14.19 9.70 38 136087 6425 63346472
Rotator cuff syndrome 14.17 9.70 62 136063 13440 63339457
Administration site scar 14.13 9.70 5 136120 47 63352850
Mastocytosis 14.12 9.70 11 136114 575 63352322
Localised infection 14.11 9.70 112 136013 30098 63322799
Hypomagnesaemia 14.07 9.70 25 136100 28712 63324185
Sedation complication 14.05 9.70 6 136119 13816 63339081
Macular degeneration 14.04 9.70 19 136106 24357 63328540
Epidural analgesia 14.04 9.70 5 136120 48 63352849
Smoke sensitivity 14.03 9.70 10 136115 456 63352441
Postpartum disorder 13.99 9.70 4 136121 17 63352880
Gastrointestinal bacterial overgrowth 13.95 9.70 13 136112 869 63352028
Distributive shock 13.94 9.70 16 136109 1367 63351530
Oropharyngeal pain 13.88 9.70 282 135843 94205 63258692
Rhabdomyolysis 13.86 9.70 48 136077 43903 63308994
Cardiac assistance device user 13.77 9.70 5 136120 51 63352846
Peritonitis 13.76 9.70 10 136115 17144 63335753
Cough 13.71 9.70 763 135362 291980 63060917
Allergic reaction to excipient 13.59 9.70 9 136116 364 63352533
Paraesthesia oral 13.56 9.70 79 136046 19177 63333720
Injection site haemorrhage 13.55 9.70 94 136031 24220 63328677
Pupil fixed 13.51 9.70 18 136107 1791 63351106
SARS-CoV-2 test positive 13.49 9.70 43 136082 8013 63344884
Trigeminal palsy 13.47 9.70 4 136121 20 63352877
Incision site rash 13.47 9.70 4 136121 20 63352877
Delayed recovery from anaesthesia 13.44 9.70 12 136113 759 63352138
Concussion 13.41 9.70 47 136078 9197 63343700
Procedural anxiety 13.37 9.70 12 136113 764 63352133
Nerve root injury cervical 13.37 9.70 3 136122 3 63352894
SARS-CoV-2 test false positive 13.37 9.70 3 136122 3 63352894
Quadriparesis 13.36 9.70 19 136106 2010 63350887
Obstruction 13.31 9.70 24 136101 3103 63349794
Vaccination site rash 13.30 9.70 4 136121 21 63352876
Caffeine allergy 13.30 9.70 4 136121 21 63352876
Ehlers-Danlos syndrome 13.25 9.70 7 136118 185 63352712
COVID-19 pneumonia 13.24 9.70 63 136062 14146 63338751
Nephrolithiasis 13.21 9.70 143 135982 41841 63311056
Myocardial necrosis marker increased 13.15 9.70 18 136107 1838 63351059
Gastroenteritis 13.14 9.70 23 136102 26567 63326330
Diplegia 13.12 9.70 14 136111 1103 63351794
Malabsorption from administration site 13.06 9.70 6 136119 116 63352781
Corneal abrasion 13.04 9.70 14 136111 1110 63351787
Accelerated idioventricular rhythm 13.04 9.70 5 136120 60 63352837
Spinal epidural haematoma 13.01 9.70 14 136111 1113 63351784
Forced vital capacity abnormal 13 9.70 4 136121 23 63352874
Pancreatitis acute 12.97 9.70 24 136101 27142 63325755
Psychotic disorder 12.92 9.70 22 136103 25690 63327207
Adjustment disorder with depressed mood 12.92 9.70 3 136122 10201 63342696
Paranasal cyst 12.87 9.70 9 136116 398 63352499
Injection site extravasation 12.86 9.70 45 136080 8796 63344101
Lyme disease 12.85 9.70 25 136100 3424 63349473
Drainage 12.85 9.70 7 136118 197 63352700
Nail bed tenderness 12.83 9.70 9 136116 400 63352497
Dry mouth 12.81 9.70 106 136019 77757 63275140
Facet joint syndrome 12.78 9.70 5 136120 12133 63340764
Chondromalacia 12.76 9.70 8 136117 294 63352603
Tongue pruritus 12.75 9.70 10 136115 528 63352369
Rubber sensitivity 12.73 9.70 20 136105 2311 63350586
Thermal burn 12.73 9.70 35 136090 6011 63346886
Post-anoxic myoclonus 12.72 9.70 4 136121 25 63352872
Infusion site vesicles 12.70 9.70 10 136115 531 63352366
Urticarial vasculitis 12.70 9.70 11 136114 668 63352229
Autonomic neuropathy 12.69 9.70 14 136111 1145 63351752
Lung neoplasm malignant 12.69 9.70 14 136111 19619 63333278
Throat irritation 12.68 9.70 130 135995 37517 63315380
Administration site rash 12.68 9.70 5 136120 65 63352832
Laryngeal obstruction 12.65 9.70 6 136119 125 63352772
Coronary artery disease 12.64 9.70 32 136093 32345 63320552
Aspartate aminotransferase increased 12.64 9.70 128 135997 90149 63262748
Respiratory tract oedema 12.64 9.70 10 136115 535 63352362
Hyperthermia malignant 12.63 9.70 12 136113 822 63352075
Hallucination, tactile 12.59 9.70 8 136117 301 63352596
Purpura 12.50 9.70 53 136072 11332 63341565
Metastases to bone 12.50 9.70 16 136109 21003 63331894
Haemoglobin decreased 12.49 9.70 228 135897 145257 63207640
Airway complication of anaesthesia 12.47 9.70 7 136118 209 63352688
Blood glucose increased 12.47 9.70 117 136008 83639 63269258
Heart rate decreased 12.46 9.70 151 135974 45409 63307488
Respiratory tract congestion 12.45 9.70 73 136052 17759 63335138
Peripheral venous disease 12.44 9.70 9 136116 15468 63337429
Cold urticaria 12.44 9.70 6 136119 130 63352767
Gastric mucosa erythema 12.43 9.70 8 136117 308 63352589
Suicide attempt 12.41 9.70 78 136047 60840 63292057
Weight increased 12.36 9.70 446 135679 260346 63092551
Wheezing 12.33 9.70 280 135845 95315 63257582
Bradycardia foetal 12.32 9.70 9 136116 427 63352470
Colour blindness 12.31 9.70 8 136117 313 63352584
Hyperlactacidaemia 12.30 9.70 22 136103 2827 63350070
Gamma-glutamyltransferase increased 12.26 9.70 35 136090 33996 63318901
Food poisoning 12.26 9.70 28 136097 4288 63348609
Administration site mass 12.21 9.70 4 136121 29 63352868
Blindness 12.16 9.70 84 136041 21615 63331282
Speech disorder 12.15 9.70 137 135988 40492 63312405
Hypercapnia 12.00 9.70 32 136093 5399 63347498
CSF pressure increased 11.99 9.70 6 136119 141 63352756
Dysphemia 11.99 9.70 21 136104 2654 63350243
Blood pressure immeasurable 11.99 9.70 14 136111 1218 63351679
Procedural haemorrhage 11.92 9.70 21 136104 2667 63350230
Diabetes mellitus inadequate control 11.90 9.70 9 136116 15117 63337780
Ascites 11.85 9.70 46 136079 40682 63312215
Left ventricular dysfunction 11.79 9.70 54 136071 11934 63340963
Diabetic ketoacidosis 11.79 9.70 16 136109 20489 63332408
Inadequate analgesia 11.79 9.70 22 136103 2921 63349976
Spinal cord oedema 11.77 9.70 6 136119 147 63352750
Irregular breathing 11.73 9.70 8 136117 340 63352557
Transferrin decreased 11.63 9.70 7 136118 239 63352658
Tooth abscess 11.59 9.70 63 136062 14906 63337991
Anal sphincter atony 11.52 9.70 7 136118 243 63352654
Lip disorder 11.52 9.70 15 136110 1459 63351438
Vascular stenosis 11.48 9.70 8 136117 352 63352545
Blood immunoglobulin G abnormal 11.46 9.70 4 136121 36 63352861
Immunodeficiency 11.45 9.70 16 136109 20238 63332659
Cutis laxa 11.44 9.70 6 136119 156 63352741
Disseminated intravascular coagulation 11.43 9.70 75 136050 18976 63333921
Implant site bruising 11.42 9.70 8 136117 355 63352542
Visual acuity reduced 11.36 9.70 83 136042 21743 63331154
Propionibacterium infection 11.36 9.70 4 136121 37 63352860
Agranulocytosis 11.31 9.70 23 136102 25111 63327786
Application site alopecia 11.30 9.70 3 136122 9 63352888
Decreased ventricular preload 11.30 9.70 3 136122 9 63352888
Palmar-plantar erythrodysaesthesia syndrome 11.29 9.70 20 136105 22995 63329902
Hypoxic-ischaemic encephalopathy 11.29 9.70 27 136098 4260 63348637
Night sweats 11.29 9.70 60 136065 48754 63304143
Foetal heart rate abnormal 11.28 9.70 10 136115 627 63352270
Mucosal inflammation 11.23 9.70 57 136068 46871 63306026
Idiopathic urticaria 11.22 9.70 7 136118 255 63352642
Hypoglycaemia 11.19 9.70 79 136046 59986 63292911
XIIth nerve injury 11.06 9.70 3 136122 10 63352887
Multiple sclerosis relapse 10.98 9.70 60 136065 48418 63304479
Device use issue 10.96 9.70 20 136105 2610 63350287
Treatment noncompliance 10.96 9.70 42 136083 37283 63315614
Liver function test increased 10.92 9.70 35 136090 32776 63320121
Electrocardiogram U wave present 10.91 9.70 5 136120 96 63352801
Vascular resistance systemic decreased 10.87 9.70 5 136120 97 63352800
Hemiplegic migraine 10.87 9.70 5 136120 97 63352800
Epinephrine increased 10.84 9.70 3 136122 11 63352886
Capillary nail refill test abnormal 10.83 9.70 4 136121 43 63352854
Overdose 10.75 9.70 323 135802 114755 63238142
Hyperkalaemia 10.74 9.70 70 136055 54133 63298764
Cardiac arrest neonatal 10.73 9.70 5 136120 100 63352797
Hypoxia 10.70 9.70 184 135941 59608 63293289
Arthropod sting 10.69 9.70 13 136112 1180 63351717
Sensitive skin 10.64 9.70 16 136109 1780 63351117
Heliotrope rash 10.64 9.70 6 136119 181 63352716
Rash maculo-papular 10.63 9.70 34 136091 31862 63321035
Vocal cord disorder 10.62 9.70 14 136111 1379 63351518
Sedation 10.55 9.70 45 136080 38764 63314133
Infusion site hypersensitivity 10.51 9.70 4 136121 47 63352850
Right ventricular dysfunction 10.49 9.70 16 136109 1803 63351094
Medical device site infection 10.48 9.70 7 136118 287 63352610
Infusion site haematoma 10.46 9.70 7 136118 288 63352609
Victim of spousal abuse 10.45 9.70 3 136122 13 63352884
Product administration error 10.44 9.70 83 136042 22314 63330583
Intraocular pressure fluctuation 10.43 9.70 4 136121 48 63352849
Orbital infection 10.43 9.70 4 136121 48 63352849
Anaphylactoid syndrome of pregnancy 10.43 9.70 4 136121 48 63352849
Cholestasis of pregnancy 10.42 9.70 13 136112 1212 63351685
Premature delivery 10.41 9.70 105 136020 30176 63322721
Low cardiac output syndrome 10.36 9.70 8 136117 413 63352484
Pain in jaw 10.32 9.70 53 136072 43443 63309454
Central venous catheter removal 10.27 9.70 8 136117 418 63352479
Ocular retrobulbar haemorrhage 10.25 9.70 5 136120 111 63352786
Injection site swelling 10.25 9.70 151 135974 47421 63305476
Cardiovascular insufficiency 10.24 9.70 14 136111 1427 63351470
Metapneumovirus infection 10.24 9.70 12 136113 1048 63351849
Breast cancer stage II 10.24 9.70 3 136122 8733 63344164
N-terminal prohormone brain natriuretic peptide 10.21 9.70 4 136121 51 63352846
Brain stem syndrome 10.21 9.70 8 136117 422 63352475
Orbital oedema 10.17 9.70 7 136118 302 63352595
Infusion site injury 10.14 9.70 4 136121 52 63352845
Post-acute COVID-19 syndrome 10.11 9.70 8 136117 428 63352469
Arthritis fungal 10.10 9.70 3 136122 15 63352882
Vitamin E decreased 10.10 9.70 3 136122 15 63352882
Coccygectomy 10.10 9.70 3 136122 15 63352882
Nail bed infection bacterial 10.10 9.70 3 136122 15 63352882
Conduction disorder 10.05 9.70 14 136111 1453 63351444
Biopsy lung 10.04 9.70 6 136119 202 63352695
Foetal exposure during pregnancy 10.02 9.70 35 136090 31927 63320970
Cataract 10.00 9.70 175 135950 56878 63296019
Optic atrophy 9.98 9.70 13 136112 1265 63351632
Eye infection staphylococcal 9.98 9.70 5 136120 118 63352779
Hepatic cytolysis 9.94 9.70 11 136114 15396 63337501
Hyperglycaemia 9.94 9.70 51 136074 41816 63311081
Pneumocystis jirovecii pneumonia 9.93 9.70 13 136112 16901 63335996
Muscle tension dysphonia 9.88 9.70 6 136119 208 63352689
Chronic kidney disease 9.84 9.70 57 136068 45341 63307556
Epidural haemorrhage 9.82 9.70 5 136120 122 63352775
Allergy to immunoglobulin therapy 9.81 9.70 4 136121 57 63352840
Vaginal abscess 9.81 9.70 8 136117 447 63352450
Sinus bradycardia 9.79 9.70 59 136066 14492 63338405
Iris hypopigmentation 9.79 9.70 3 136122 17 63352880
Foot deformity 9.77 9.70 29 136096 27824 63325073
Tremor 9.76 9.70 361 135764 131878 63221019
Benign vulval neoplasm 9.75 9.70 4 136121 58 63352839
Tuberculosis 9.71 9.70 6 136119 11205 63341692

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device failure 372.58 10.53 150 69827 2226 34884728
Drug ineffective 358.82 10.53 1828 68149 454923 34432031
Sinusitis 353.47 10.53 425 69552 40977 34845977
Anaphylactic reaction 353.05 10.53 377 69600 31924 34855030
Anaphylactic shock 268.42 10.53 236 69741 15705 34871249
Anaesthetic complication 244.62 10.53 90 69887 1030 34885924
Cardiac arrest 242.30 10.53 570 69407 95589 34791365
Toxic anterior segment syndrome 194.39 10.53 77 69900 1092 34885862
Methaemoglobinaemia 178.73 10.53 103 69874 3478 34883476
Local anaesthetic systemic toxicity 161.36 10.53 48 69929 262 34886692
Chondrolysis 160.40 10.53 39 69938 79 34886875
Hereditary angioedema 150.13 10.53 62 69915 985 34885969
Injury 147.17 10.53 194 69783 20493 34866461
Fear 146.86 10.53 140 69837 10336 34876618
Hypotension 141.61 10.53 841 69136 220808 34666146
Ear infection 138.27 10.53 134 69843 10097 34876857
Renal injury 135.35 10.53 138 69839 11057 34875897
Infusion site swelling 129.72 10.53 74 69903 2450 34884504
Infusion site pain 126.77 10.53 85 69892 3766 34883188
Stress cardiomyopathy 123.97 10.53 67 69910 1992 34884962
Electrocardiogram ST segment elevation 116.17 10.53 91 69886 5147 34881807
Ventricular tachycardia 114.23 10.53 197 69780 26382 34860572
Emotional distress 113.24 10.53 145 69832 14881 34872073
Bradycardia 110.30 10.53 367 69610 75051 34811903
Anhedonia 109.43 10.53 103 69874 7482 34879472
Kounis syndrome 103.71 10.53 64 69913 2454 34884500
Accidental exposure to product 100.37 10.53 126 69851 12676 34874278
Needle issue 99.22 10.53 89 69888 6076 34880878
Infusion site extravasation 97.49 10.53 76 69901 4268 34882686
Ventricular fibrillation 97.16 10.53 169 69808 22785 34864169
Injection site pallor 93.90 10.53 19 69958 6 34886948
Injection site laceration 92.59 10.53 20 69957 16 34886938
Arteriospasm coronary 88.82 10.53 65 69912 3317 34883637
Upper respiratory tract infection 87.50 10.53 200 69777 32859 34854095
Lagophthalmos 85.87 10.53 23 69954 79 34886875
Unevaluable event 83.87 10.53 195 69782 32395 34854559
Drug ineffective for unapproved indication 83.19 10.53 161 69816 23554 34863400
Bronchospasm 83.14 10.53 105 69872 10626 34876328
Diarrhoea 82.38 10.53 452 69525 389460 34497494
Device use issue 81.33 10.53 35 69942 619 34886335
Product quality issue 80.83 10.53 132 69845 16903 34870051
Infusion site erythema 79.24 10.53 52 69925 2221 34884733
Accidental exposure to product by child 77.80 10.53 44 69933 1432 34885522
Stress 76.37 10.53 180 69797 30167 34856787
COVID-19 74.32 10.53 330 69647 77220 34809734
Injury associated with device 71.70 10.53 38 69939 1085 34885869
Completed suicide 67.87 10.53 58 69919 98110 34788844
Tachycardia 66.88 10.53 341 69636 84431 34802523
Expired product administered 65.49 10.53 54 69923 3287 34883667
Incorrect route of product administration 65.04 10.53 111 69866 14734 34872220
Pain 61.51 10.53 653 69324 204022 34682932
Insurance issue 60.00 10.53 42 69935 1997 34884957
General physical health deterioration 59.85 10.53 103 69874 128166 34758788
Shock 59.30 10.53 142 69835 24037 34862917
Infusion site pruritus 58.71 10.53 30 69947 793 34886161
Hypoxic-ischaemic encephalopathy 58.69 10.53 58 69919 4474 34882480
Disease progression 57.90 10.53 79 69898 107998 34778956
Interstitial lung disease 56.61 10.53 30 69947 65252 34821702
Anaemia 55.67 10.53 259 69718 233076 34653878
Electrocardiogram QRS complex prolonged 54.96 10.53 58 69919 4836 34882118
Decreased appetite 54.53 10.53 162 69815 166230 34720724
Dermatitis atopic 54.15 10.53 60 69917 5287 34881667
Vasoplegia syndrome 54.08 10.53 38 69939 1818 34885136
Endophthalmitis 53.23 10.53 49 69928 3459 34883495
Cardiogenic shock 51.51 10.53 143 69834 26475 34860479
Injection site injury 49.59 10.53 19 69958 245 34886709
Hyperthermia malignant 48.66 10.53 38 69939 2139 34884815
Haemodynamic instability 48.19 10.53 76 69901 9447 34877507
Metabolic acidosis 47.33 10.53 193 69784 43487 34843467
Pulse absent 46.90 10.53 58 69919 5745 34881209
Infusion site bruising 46.88 10.53 25 69952 723 34886231
Unresponsive to stimuli 46.50 10.53 141 69836 27428 34859526
Infusion site rash 45.57 10.53 22 69955 513 34886441
Overdose 45.37 10.53 325 69652 90734 34796220
Sinus tachycardia 44.79 10.53 104 69873 17256 34869698
Accidental overdose 43.82 10.53 113 69864 20027 34866927
Multiple allergies 43.74 10.53 41 69936 2962 34883992
Multiple organ dysfunction syndrome 43.33 10.53 282 69695 76284 34810670
Urticaria 41.78 10.53 240 69737 62137 34824817
Cauda equina syndrome 40.76 10.53 21 69956 565 34886389
Asthenia 40.53 10.53 306 69671 244945 34642009
Respiratory tract infection 40.23 10.53 108 69869 19604 34867350
Generalised tonic-clonic seizure 40.23 10.53 113 69864 21061 34865893
Leukopenia 40.04 10.53 40 69937 62816 34824138
Pulseless electrical activity 39.93 10.53 60 69917 7151 34879803
Nasopharyngitis 39.77 10.53 258 69719 69710 34817244
Respiratory depression 39.39 10.53 95 69882 16150 34870804
Incorrect drug administration rate 38.63 10.53 30 69947 1675 34885279
Hypoxia 38.22 10.53 214 69763 54881 34832073
Illness 38.19 10.53 84 69893 13445 34873509
Corneal reflex decreased 38.14 10.53 14 69963 159 34886795
Toxicity to various agents 37.89 10.53 587 69390 199775 34687179
Wrong product administered 37.88 10.53 50 69927 5284 34881670
Hypersensitivity 37.76 10.53 230 69747 60805 34826149
Seasonal allergy 37.62 10.53 56 69921 6619 34880335
Malignant neoplasm progression 37.24 10.53 75 69902 87971 34798983
Injection site coldness 37.09 10.53 9 69968 18 34886936
Thrombocytopenia 36.88 10.53 174 69803 156073 34730881
Infusion related reaction 36.75 10.53 206 69771 52851 34834103
Acute kidney injury 35.98 10.53 414 69563 304574 34582380
Impaired quality of life 35.98 10.53 51 69926 5767 34881187
Anaesthetic complication neurological 35.25 10.53 16 69961 323 34886631
Injection site pain 35.10 10.53 163 69814 38842 34848112
Infusion site haemorrhage 35.07 10.53 23 69954 981 34885973
Neuromuscular block prolonged 34.98 10.53 18 69959 483 34886471
Liquid product physical issue 34.95 10.53 18 69959 484 34886470
Post procedural complication 34.78 10.53 73 69904 11315 34875639
Infusion site nodule 34.51 10.53 12 69965 115 34886839
Mydriasis 34.22 10.53 56 69921 7181 34879773
Pancytopenia 33.84 10.53 89 69888 95068 34791886
Corneal oedema 33.31 10.53 25 69952 1326 34885628
Factor V Leiden mutation 33.27 10.53 11 69966 89 34886865
Ventricular extrasystoles 33.26 10.53 74 69903 11934 34875020
Haemoglobin decreased 33.10 10.53 127 69850 120645 34766309
Hyperdynamic left ventricle 33.03 10.53 13 69964 181 34886773
Death 32.95 10.53 580 69397 397469 34489485
White blood cell count decreased 32.64 10.53 91 69886 95354 34791600
Rheumatoid arthritis 32.51 10.53 18 69959 38220 34848734
Neutropenia 32.25 10.53 183 69794 156595 34730359
Medical device site laceration 31.29 10.53 6 69971 0 34886954
Weight decreased 31.01 10.53 216 69761 176085 34710869
Eyelid rash 30.74 10.53 9 69968 46 34886908
Coma 30.74 10.53 176 69801 45502 34841452
Psoriasis 30.58 10.53 20 69957 38792 34848162
Administration site pain 30.42 10.53 14 69963 292 34886662
Retinal artery occlusion 29.91 10.53 27 69950 1858 34885096
Cardiotoxicity 29.87 10.53 46 69931 5602 34881352
Swollen tongue 29.78 10.53 80 69897 14525 34872429
Anal inflammation 29.72 10.53 23 69954 1277 34885677
Melaena 29.59 10.53 17 69960 35363 34851591
Delayed recovery from anaesthesia 29.58 10.53 19 69958 782 34886172
Procedural haemorrhage 29.17 10.53 30 69947 2427 34884527
Cardiac failure congestive 28.76 10.53 79 69898 83191 34803763
Anxiety 28.75 10.53 315 69662 99113 34787841
Eye infection 28.54 10.53 36 69941 3637 34883317
Oculocardiac reflex 28.48 10.53 9 69968 62 34886892
Asthma 28.47 10.53 164 69813 42492 34844462
Administration site swelling 28.26 10.53 12 69965 205 34886749
Laryngeal oedema 28.25 10.53 35 69942 3473 34883481
Coagulation factor deficiency 28.22 10.53 11 69966 149 34886805
Mean arterial pressure decreased 28.09 10.53 11 69966 151 34886803
Oedema peripheral 27.92 10.53 134 69843 119678 34767276
Angioedema 27.82 10.53 148 69829 37226 34849728
Brain oedema 27.48 10.53 75 69902 13746 34873208
Spinal cord infarction 27.45 10.53 13 69964 290 34886664
Coronary artery disease 27.19 10.53 34 69943 48271 34838683
Bronchopulmonary aspergillosis allergic 27.02 10.53 19 69958 910 34886044
Apnoea 26.81 10.53 48 69929 6616 34880338
Drug intolerance 26.70 10.53 49 69928 59521 34827433
Dehydration 26.56 10.53 152 69825 129817 34757137
Systolic anterior motion of mitral valve 25.50 10.53 7 69970 27 34886927
Injection site hypoaesthesia 25.45 10.53 9 69968 91 34886863
Agranulocytosis 25.42 10.53 8 69969 23813 34863141
Brain stem syndrome 24.91 10.53 15 69962 550 34886404
Gastroenteritis viral 24.53 10.53 48 69929 7076 34879878
Myocardial stunning 24.40 10.53 6 69971 13 34886941
Hypopyon 24.16 10.53 13 69964 383 34886571
Cyanosis 24.12 10.53 68 69909 12696 34874258
Tryptase increased 24.05 10.53 11 69966 226 34886728
Product dose omission issue 23.85 10.53 354 69623 119357 34767597
Electrocardiogram ST segment depression 23.80 10.53 27 69950 2441 34884513
Ventricular arrhythmia 23.77 10.53 41 69936 5487 34881467
Removal of foreign body 23.72 10.53 7 69970 37 34886917
Macroglossia 23.71 10.53 13 69964 398 34886556
Chemical burn 23.45 10.53 11 69966 240 34886714
Platelet count decreased 23.40 10.53 142 69835 119575 34767379
SARS-CoV-2 test negative 23.22 10.53 18 69959 1002 34885952
Injection site discolouration 22.93 10.53 21 69956 1472 34885482
Trigemino-cardiac reflex 22.92 10.53 10 69967 183 34886771
Blood pressure decreased 22.88 10.53 179 69798 51336 34835618
Pancreatitis acute 22.86 10.53 14 69963 28127 34858827
Aqueous fibrin 22.83 10.53 7 69970 43 34886911
Blood pressure fluctuation 22.78 10.53 11 69966 25238 34861716
Hypoglycaemia 22.71 10.53 47 69930 54593 34832361
Pulmonary oedema 22.70 10.53 168 69809 47361 34839593
Headache 22.23 10.53 542 69435 200093 34686861
Circulatory collapse 22.02 10.53 92 69885 20946 34866008
Anal sphincter atony 21.94 10.53 8 69969 89 34886865
Gastrointestinal haemorrhage 21.76 10.53 97 69880 88380 34798574
Croup infectious 21.60 10.53 12 69965 377 34886577
Prostate cancer 21.19 10.53 29 69948 39620 34847334
International normalised ratio increased 21.15 10.53 39 69938 47288 34839666
Respiratory acidosis 21.12 10.53 37 69940 5013 34881941
Embolia cutis medicamentosa 20.88 10.53 10 69967 229 34886725
Dyspnoea exertional 20.85 10.53 34 69943 43245 34843709
Respiratory arrest 20.83 10.53 111 69866 27932 34859022
Transient ischaemic attack 20.72 10.53 15 69962 27598 34859356
Left ventricle outflow tract obstruction 20.67 10.53 9 69968 164 34886790
Jaundice 20.63 10.53 20 69957 31862 34855092
Suicide attempt 20.52 10.53 29 69948 39087 34847867
Loss of consciousness 20.37 10.53 254 69723 82413 34804541
Myalgia 20.21 10.53 93 69884 84017 34802937
Procedural hypotension 20.19 10.53 16 69961 920 34886034
Device malfunction 20.17 10.53 56 69921 10365 34876589
Infusion site mass 20.11 10.53 11 69966 335 34886619
Procedural complication 20.06 10.53 33 69944 4250 34882704
Allergy to arthropod sting 19.97 10.53 8 69969 117 34886837
Accident 19.85 10.53 36 69941 5011 34881943
Neuromuscular blockade 19.79 10.53 10 69967 258 34886696
Chondromalacia 19.70 10.53 5 69972 13 34886941
Administration site erythema 19.69 10.53 7 69970 72 34886882
Pupil fixed 19.61 10.53 21 69956 1780 34885174
Hepatocellular injury 19.55 10.53 10 69967 22201 34864753
Skin texture abnormal 19.42 10.53 6 69971 38 34886916
Product use in unapproved indication 19.11 10.53 336 69641 117163 34769791
Myocardial infarction 19.05 10.53 153 69824 120932 34766022
Coagulation factor V level abnormal 18.78 10.53 6 69971 43 34886911
Familial periodic paralysis 18.72 10.53 7 69970 84 34886870
Alopecia 18.58 10.53 13 69964 24342 34862612
Skin infection 18.49 10.53 45 69932 7692 34879262
Haematuria 18.42 10.53 46 69931 50020 34836934
Neoplasm progression 18.36 10.53 12 69965 23288 34863666
Drug resistance 18.29 10.53 15 69962 25912 34861042
Respiratory tract infection bacterial 18.05 10.53 20 69957 1762 34885192
Atrioventricular block complete 17.96 10.53 50 69927 9269 34877685
Intentional self-injury 17.92 10.53 3 69974 13768 34873186
Musculoskeletal stiffness 17.88 10.53 42 69935 46638 34840316
BRASH syndrome 17.85 10.53 12 69965 534 34886420
Angina pectoris 17.73 10.53 22 69955 31341 34855613
Intracranial hypotension 17.71 10.53 9 69968 235 34886719
Oxygen saturation decreased 17.66 10.53 175 69802 53643 34833311
Drug-induced liver injury 17.62 10.53 19 69958 28813 34858141
Drug interaction 17.44 10.53 333 69644 225613 34661341
Mouth swelling 17.38 10.53 20 69957 1836 34885118
Cytomegalovirus infection 17.37 10.53 16 69961 26119 34860835
Coma neonatal 17.34 10.53 5 69972 24 34886930
Cholestasis 17.32 10.53 17 69960 26931 34860023
Phaeochromocytoma crisis 17.30 10.53 6 69971 57 34886897
Hyponatraemia 17.26 10.53 96 69881 82595 34804359
Pharyngeal swelling 17.23 10.53 22 69955 2250 34884704
Anion gap 16.97 10.53 14 69963 853 34886101
Respiratory tract infection viral 16.96 10.53 23 69954 2494 34884460
Insomnia 16.94 10.53 130 69847 103777 34783177
Cardiac arrest neonatal 16.85 10.53 5 69972 27 34886927
Infusion site irritation 16.67 10.53 9 69968 267 34886687
Anterior chamber cell 16.65 10.53 10 69967 365 34886589
Bronchitis 16.57 10.53 142 69835 41821 34845133
Diabetes mellitus 16.53 10.53 44 69933 46829 34840125
Reperfusion arrhythmia 16.52 10.53 6 69971 66 34886888
Bladder cancer 16.44 10.53 6 69971 16272 34870682
Seizure like phenomena 16.35 10.53 13 69964 751 34886203
Hallucination 16.22 10.53 51 69926 51447 34835507
Fatigue 16.01 10.53 594 69383 370059 34516895
Orthostatic hypotension 15.93 10.53 17 69960 25902 34861052
Catecholamine crisis 15.88 10.53 5 69972 34 34886920
Administration site irritation 15.87 10.53 4 69973 10 34886944
Ophthalmoplegia 15.86 10.53 19 69958 1821 34885133
Eyelid oedema 15.82 10.53 33 69944 5091 34881863
Seizure 15.70 10.53 296 69681 104561 34782393
Administration site scar 15.65 10.53 3 69974 0 34886954
Injection site extravasation 15.61 10.53 24 69953 2918 34884036
Abdominal pain 15.59 10.53 232 69745 163386 34723568
Food allergy 15.59 10.53 17 69960 1471 34885483
Medication error 15.58 10.53 96 69881 25469 34861485
Hepatitis 15.46 10.53 15 69962 23889 34863065
Injection site scar 15.40 10.53 9 69968 312 34886642
Paraesthesia oral 15.33 10.53 29 69948 4168 34882786
Rhinitis 15.29 10.53 37 69940 6301 34880653
Throat tightness 15.28 10.53 44 69933 8314 34878640
Dry gangrene 15.20 10.53 10 69967 429 34886525
Pulmonary fibrosis 15.15 10.53 9 69968 18387 34868567
Areflexia 15.07 10.53 24 69953 3007 34883947
Gamma-glutamyltransferase increased 15.00 10.53 22 69955 29209 34857745
Tracheitis 14.96 10.53 12 69965 702 34886252
Liver disorder 14.91 10.53 27 69950 32970 34853984
Myopathy toxic 14.80 10.53 11 69966 575 34886379
Haematochezia 14.71 10.53 46 69931 46488 34840466
Vitritis 14.61 10.53 13 69964 878 34886076
Product adhesion issue 14.58 10.53 17 69960 1583 34885371
Vitreous disorder 14.54 10.53 6 69971 95 34886859
Accelerated idioventricular rhythm 14.51 10.53 7 69970 163 34886791
Pneumocystis jirovecii pneumonia 14.41 10.53 11 69966 19699 34867255
COVID-19 immunisation 14.41 10.53 8 69969 251 34886703
Pharyngitis streptococcal 14.39 10.53 22 69955 2662 34884292
Electrocardiogram T wave amplitude increased 14.37 10.53 5 69972 48 34886906
Injury corneal 14.26 10.53 4 69973 17 34886937
Respiratory distress 14.25 10.53 121 69856 35544 34851410
Torsade de pointes 14.21 10.53 39 69938 7170 34879784
Polyneuropathy 14.20 10.53 6 69971 14890 34872064
Paralysis 14.14 10.53 35 69942 6047 34880907
Drug reaction with eosinophilia and systemic symptoms 14.05 10.53 28 69949 32984 34853970
Cardiac failure 14.02 10.53 116 69861 91132 34795822
Viral infection 13.95 10.53 71 69906 17552 34869402
Hepatic function abnormal 13.92 10.53 44 69933 44319 34842635
Blood lactic acid increased 13.86 10.53 37 69940 6691 34880263
Alanine aminotransferase increased 13.70 10.53 100 69877 80715 34806239
Pupillary reflex impaired 13.61 10.53 16 69961 1503 34885451
Administration site pruritus 13.58 10.53 4 69973 21 34886933
General anaesthesia 13.57 10.53 3 69974 3 34886951
Toxic epidermal necrolysis 13.52 10.53 14 69963 21632 34865322
Type I hypersensitivity 13.51 10.53 15 69962 1324 34885630
Sinus arrest 13.43 10.53 17 69960 1723 34885231
Vitreous floaters 13.38 10.53 25 69952 3560 34883394
Product distribution issue 13.36 10.53 11 69966 668 34886286
Recalled product administered 13.31 10.53 10 69967 531 34886423
Disease recurrence 13.31 10.53 14 69963 21476 34865478
Spinal cord oedema 13.30 10.53 7 69970 197 34886757
Constipation 13.13 10.53 194 69783 136788 34750166
Electrocardiogram ST-T segment depression 13.11 10.53 3 69974 4 34886950
Retinal vasculitis 13.06 10.53 9 69968 417 34886537
Paraplegia 13.06 10.53 22 69955 2889 34884065
Respiratory syncytial virus infection 13.02 10.53 29 69948 4680 34882274
Gas gangrene 12.88 10.53 5 69972 67 34886887
Infusion site vesicles 12.77 10.53 7 69970 214 34886740
Neuralgia 12.75 10.53 62 69915 15051 34871903
Blood creatinine increased 12.73 10.53 125 69852 94851 34792103
Device infusion issue 12.73 10.53 12 69965 873 34886081
Liver function test abnormal 12.68 10.53 27 69950 31047 34855907
Corneal opacity 12.60 10.53 10 69967 576 34886378
Injection site joint infection 12.60 10.53 4 69973 28 34886926
Foreign body 12.54 10.53 13 69964 1061 34885893
Stridor 12.51 10.53 20 69957 2514 34884440
Injection site discharge 12.51 10.53 7 69970 223 34886731
Deep vein thrombosis 12.42 10.53 78 69899 65170 34821784
End-tidal CO2 decreased 12.36 10.53 3 69974 6 34886948
Proctalgia 12.33 10.53 32 69945 5691 34881263
Gait disturbance 12.30 10.53 110 69867 85030 34801924
Bone marrow failure 12.29 10.53 25 69952 29228 34857726
Weight increased 12.24 10.53 123 69854 92910 34794044
Pharyngeal oedema 12.20 10.53 33 69944 6014 34880940
Hypercalcaemia 12.14 10.53 8 69969 15460 34871494
Infusion site infection 12.11 10.53 9 69968 470 34886484
Non-infectious endophthalmitis 11.90 10.53 6 69971 154 34886800
Infusion site urticaria 11.87 10.53 6 69971 155 34886799
Administration site reaction 11.74 10.53 5 69972 86 34886868
Myoclonic epilepsy 11.74 10.53 13 69964 1144 34885810
Joint swelling 11.71 10.53 71 69906 59819 34827135
Ventricular tachyarrhythmia 11.70 10.53 8 69969 366 34886588
Myokymia 11.69 10.53 5 69972 87 34886867
Malaise 11.67 10.53 283 69694 185542 34701412
Eye inflammation 11.64 10.53 18 69959 2200 34884754
Tubulointerstitial nephritis 11.62 10.53 15 69962 21009 34865945
Product administered at inappropriate site 11.53 10.53 18 69959 2218 34884736
Migraine 11.53 10.53 67 69910 17411 34869543
Anaphylactoid shock 11.43 10.53 8 69969 380 34886574
Multiple sclerosis relapse 11.43 10.53 6 69971 13127 34873827
Red blood cell count decreased 11.28 10.53 26 69951 29064 34857890
Quadriplegia 11.27 10.53 16 69961 1811 34885143
Burkholderia test positive 11.27 10.53 12 69965 1011 34885943
Compartment syndrome 11.21 10.53 21 69956 2997 34883957
Syncope 11.18 10.53 123 69854 91328 34795626
Administration related reaction 11.15 10.53 5 69972 98 34886856
Laryngeal stenosis 11.15 10.53 5 69972 98 34886856
Foetal exposure during pregnancy 11.12 10.53 39 69938 38062 34848892
Blood pressure systolic increased 11.08 10.53 18 69959 22934 34864020
Nodal rhythm 10.99 10.53 14 69963 1429 34885525
Treatment noncompliance 10.98 10.53 25 69952 28075 34858879
Intestinal haematoma 10.97 10.53 5 69972 102 34886852
Infusion site reaction 10.92 10.53 11 69966 868 34886086
Diabetic ketoacidosis 10.89 10.53 12 69965 18020 34868934
Chronic kidney disease 10.85 10.53 44 69933 41166 34845788
Oral lichen planus 10.84 10.53 6 69971 187 34886767
Metastases to liver 10.81 10.53 7 69970 13656 34873298
Apgar score low 10.76 10.53 11 69966 884 34886070
Foetal exposure during delivery 10.75 10.53 5 69972 107 34886847
Brown-Sequard syndrome 10.70 10.53 4 69973 48 34886906
Penile vascular disorder 10.65 10.53 3 69974 13 34886941
Thrombotic microangiopathy 10.60 10.53 4 69973 10626 34876328
Nephropathy toxic 10.59 10.53 6 69971 12582 34874372
Hypoaesthesia oral 10.54 10.53 25 69952 4204 34882750
Blood creatine phosphokinase increased 10.53 10.53 50 69927 44807 34842147
Wheezing 10.53 10.53 128 69849 41274 34845680

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic reaction 720.44 9.42 860 157610 82883 79503035
Stress cardiomyopathy 626.92 9.42 346 158124 10820 79575098
Local anaesthetic systemic toxicity 614.95 9.42 178 158292 876 79585042
Toxic anterior segment syndrome 531.79 9.42 202 158268 2562 79583356
Cardiac arrest 526.57 9.42 1098 157372 170998 79414920
Anaesthetic complication 496.74 9.42 194 158276 2665 79583253
Anaphylactic shock 481.20 9.42 467 158003 35529 79550389
Hereditary angioedema 380.63 9.42 194 158276 5141 79580777
Kounis syndrome 365.76 9.42 176 158294 4106 79581812
Device failure 348.68 9.42 193 158277 6068 79579850
Drug ineffective 335.28 9.42 3444 155026 1077469 78508449
Chondrolysis 331.17 9.42 87 158383 274 79585644
Sinusitis 299.80 9.42 962 157508 194539 79391379
Hypotension 268.41 9.42 1642 156828 438675 79147243
Completed suicide 225.56 9.42 103 158367 245664 79340254
Bradycardia 223.30 9.42 684 157786 134873 79451045
Ventricular tachycardia 223.02 9.42 341 158129 41594 79544324
Fear 210.95 9.42 239 158231 21747 79564171
Drug intolerance 209.77 9.42 133 158337 263986 79321932
Lagophthalmos 206.94 9.42 63 158407 380 79585538
Synovitis 198.45 9.42 31 158439 150703 79435215
Contraindicated product administered 197.29 9.42 37 158433 157501 79428417
Renal injury 193.84 9.42 202 158268 16725 79569193
Joint swelling 190.17 9.42 176 158294 288470 79297448
Methaemoglobinaemia 184.56 9.42 123 158347 5434 79580484
Bronchospasm 181.02 9.42 235 158235 24624 79561294
Infusion site swelling 178.86 9.42 138 158332 7688 79578230
Pulseless electrical activity 176.71 9.42 177 158293 13983 79571935
Infusion site pain 174.71 9.42 176 158294 14000 79571918
Hand deformity 172.63 9.42 8 158462 103911 79482007
COVID-19 168.48 9.42 690 157780 156984 79428934
General physical health deterioration 168.45 9.42 179 158291 275059 79310859
Ventricular fibrillation 167.49 9.42 258 158212 31668 79554250
Anhedonia 165.62 9.42 175 158295 14723 79571195
Pemphigus 161.19 9.42 9 158461 99573 79486345
Infusion site erythema 157.94 9.42 139 158331 9321 79576597
Electrocardiogram ST segment elevation 157.73 9.42 132 158338 8265 79577653
Infusion site extravasation 155.85 9.42 142 158328 9966 79575952
Incorrect route of product administration 152.89 9.42 260 158210 34669 79551249
Hepatic enzyme increased 150.45 9.42 88 158382 182522 79403396
Anti-cyclic citrullinated peptide antibody positive 150.28 9.42 3 158467 83140 79502778
Arteriospasm coronary 143.90 9.42 114 158356 6602 79579316
Shock 141.35 9.42 285 158185 43263 79542655
Cardiogenic shock 136.87 9.42 275 158195 41639 79544279
Endophthalmitis 135.35 9.42 108 158362 6320 79579598
Emotional distress 135.04 9.42 266 158204 39703 79546215
Accidental exposure to product 134.26 9.42 231 158239 31091 79554827
Infusion site pruritus 134.00 9.42 90 158380 4028 79581890
Maternal exposure during delivery 132.43 9.42 61 158409 1285 79584633
Unevaluable event 132.04 9.42 321 158149 55264 79530654
Pericarditis 131.52 9.42 24 158446 104212 79481706
Corneal oedema 130.29 9.42 75 158395 2545 79583373
Rheumatoid arthritis 129.28 9.42 134 158336 208336 79377582
Urticaria 128.92 9.42 716 157754 184485 79401433
Product quality issue 127.13 9.42 236 158234 33704 79552214
Tachycardia 126.91 9.42 692 157778 177076 79408842
Diarrhoea 125.99 9.42 1132 157338 879357 78706561
Glossodynia 125.72 9.42 26 158444 103311 79482607
Impaired quality of life 123.98 9.42 148 158322 14238 79571680
Insurance issue 122.16 9.42 97 158373 5636 79580282
Arthropathy 118.94 9.42 106 158364 177005 79408913
Illness 113.04 9.42 271 158199 46240 79539678
Drug ineffective for unapproved indication 112.34 9.42 287 158183 50951 79534967
Alopecia 111.21 9.42 180 158290 231175 79354743
Cauda equina syndrome 108.83 9.42 54 158416 1349 79584569
Upper respiratory tract infection 106.19 9.42 410 158060 90758 79495160
Injection site pallor 105.28 9.42 25 158445 44 79585874
Rheumatoid factor positive 104.92 9.42 3 158467 59836 79526082
Haemodynamic instability 104.85 9.42 150 158320 17232 79568686
Generalised tonic-clonic seizure 104.73 9.42 254 158216 43656 79542262
Injury 103.25 9.42 364 158106 77132 79508786
Ear infection 103.11 9.42 218 158252 34214 79551704
Seasonal allergy 101.06 9.42 143 158327 16263 79569655
Left ventricle outflow tract obstruction 100.94 9.42 36 158434 377 79585541
Vasoplegia syndrome 100.88 9.42 72 158398 3558 79582360
Bronchitis 100.34 9.42 519 157951 130125 79455793
Helicobacter infection 99.71 9.42 11 158459 69693 79516225
Infusion site bruising 99.63 9.42 66 158404 2886 79583032
Pulse absent 97.20 9.42 110 158360 9993 79575925
Sinus tachycardia 96.18 9.42 221 158249 36687 79549231
Needle issue 95.86 9.42 124 158346 12944 79572974
Arthralgia 95.37 9.42 705 157765 571098 79014820
Stress 94.33 9.42 360 158110 79252 79506666
Anaesthetic complication neurological 92.14 9.42 38 158432 606 79585312
Therapeutic product effect decreased 92.12 9.42 114 158356 163749 79422169
Unresponsive to stimuli 88.52 9.42 278 158192 55510 79530408
Accidental overdose 88.11 9.42 223 158247 39358 79546560
Musculoskeletal stiffness 87.08 9.42 133 158337 174875 79411043
Stridor 86.81 9.42 78 158392 5375 79580543
Infusion site haemorrhage 85.89 9.42 66 158404 3654 79582264
Injury associated with device 84.91 9.42 64 158406 3442 79582476
Multiple allergies 82.65 9.42 103 158367 10357 79575561
Wound 82.31 9.42 66 158404 116113 79469805
Systemic lupus erythematosus 81.93 9.42 72 158398 121077 79464841
Decreased appetite 81.72 9.42 376 158094 342042 79243876
Abdominal discomfort 81.69 9.42 242 158228 250485 79335433
Incorrect drug administration rate 81.28 9.42 66 158404 3960 79581958
Folliculitis 81.11 9.42 8 158462 55372 79530546
Wrong product administered 78.13 9.42 93 158377 8919 79576999
Injection site ischaemia 77.78 9.42 16 158454 7 79585911
Hypopyon 77.05 9.42 40 158430 1102 79584816
Injection site laceration 75.54 9.42 22 158448 111 79585807
Post procedural complication 75.00 9.42 154 158316 23675 79562243
Infusion site mass 74.97 9.42 44 158426 1549 79584369
Metabolic acidosis 74.93 9.42 344 158126 82185 79503733
Respiratory tract infection 74.85 9.42 240 158230 48449 79537469
Disease progression 73.12 9.42 161 158309 184201 79401717
Pulmonary oedema 72.23 9.42 357 158113 87897 79498021
Expired product administered 71.66 9.42 79 158391 6972 79578946
Neutropenia 71.59 9.42 311 158159 287399 79298519
Acute kidney injury 70.90 9.42 675 157795 518729 79067189
Asthenia 70.69 9.42 663 157807 511026 79074892
Sleep disorder due to general medical condition, insomnia type 70.28 9.42 4 158466 43552 79542366
Accidental exposure to product by child 69.95 9.42 53 158417 2873 79583045
Anaemia 69.73 9.42 558 157912 444457 79141461
Electrocardiogram QRS complex prolonged 69.07 9.42 96 158374 10737 79575181
Electrocardiogram ST segment depression 68.39 9.42 65 158405 4813 79581105
Swollen tongue 66.49 9.42 211 158259 42359 79543559
Body tinea 66.35 9.42 43 158427 1811 79584107
Muscle injury 66.18 9.42 9 158461 48552 79537366
Angioedema 66.13 9.42 313 158157 75722 79510196
Seizure 65.25 9.42 617 157853 188217 79397701
Blood pressure decreased 64.19 9.42 377 158093 99089 79486829
Procedural hypotension 62.93 9.42 43 158427 1980 79583938
Tryptase increased 62.40 9.42 29 158441 624 79585294
Overdose 62.22 9.42 599 157871 183607 79402311
C-reactive protein abnormal 61.30 9.42 11 158459 48356 79537562
Dermatitis atopic 60.98 9.42 87 158383 9969 79575949
Respiratory depression 60.80 9.42 155 158315 27475 79558443
Mobility decreased 59.66 9.42 94 158376 122081 79463837
Psoriatic arthropathy 59.52 9.42 41 158429 77958 79507960
Mydriasis 59.08 9.42 117 158353 17526 79568392
Asthma 58.47 9.42 464 158006 134631 79451287
Airway peak pressure increased 58.42 9.42 23 158447 323 79585595
Injection site injury 58.32 9.42 29 158441 728 79585190
Retinal artery occlusion 58.21 9.42 50 158420 3244 79582674
Eyelid rash 57.68 9.42 19 158451 153 79585765
Peripheral ischaemia 57.61 9.42 82 158388 9375 79576543
Product dose omission issue 57.61 9.42 748 157722 246789 79339129
Interstitial lung disease 57.52 9.42 84 158386 112516 79473402
Hyperthermia malignant 57.17 9.42 47 158423 2870 79583048
Impaired healing 56.99 9.42 54 158416 87601 79498317
Hyponatraemia 56.23 9.42 174 158296 177674 79408244
Lower respiratory tract infection 56.19 9.42 107 158363 129113 79456805
Multiple organ dysfunction syndrome 55.93 9.42 420 158050 119826 79466092
Hypoxic-ischaemic encephalopathy 55.48 9.42 73 158397 7747 79578171
Malignant neoplasm progression 55.37 9.42 117 158353 135873 79450045
Anxiety 54.13 9.42 742 157728 247770 79338148
Pancytopenia 53.94 9.42 160 158310 165585 79420333
COVID-19 immunisation 53.92 9.42 34 158436 1365 79584553
Thrombocytopenia 53.78 9.42 308 158162 264951 79320967
Circulatory collapse 52.82 9.42 180 158290 37488 79548430
Device use issue 52.77 9.42 44 158426 2740 79583178
Neuromuscular block prolonged 52.60 9.42 30 158440 1000 79584918
Hyperaesthesia 52.19 9.42 90 158380 12132 79573786
Cyanosis 52.05 9.42 138 158332 25044 79560874
Liver injury 51.45 9.42 24 158446 56590 79529328
Vitritis 50.81 9.42 36 158434 1758 79584160
Cataract operation complication 50.79 9.42 20 158450 281 79585637
Injection site coldness 50.52 9.42 16 158454 112 79585806
Hypoaesthesia oral 50.14 9.42 96 158374 14028 79571890
Hypoxia 49.37 9.42 363 158107 102880 79483038
Intentional self-injury 49.32 9.42 4 158466 32415 79553503
Type 2 diabetes mellitus 49.22 9.42 26 158444 57096 79528822
Extradural abscess 49.09 9.42 33 158437 1479 79584439
Toxicity to various agents 48.63 9.42 1138 157332 420402 79165516
Loss of consciousness 48.53 9.42 529 157941 167414 79418504
Leukopenia 48.48 9.42 99 158371 116414 79469504
Apnoea 48.43 9.42 85 158385 11619 79574299
Embolia cutis medicamentosa 47.92 9.42 24 158446 612 79585306
Cholestasis 47.50 9.42 22 158448 52087 79533831
Infusion site urticaria 47.35 9.42 29 158441 1105 79584813
Ophthalmoplegia 47.04 9.42 42 158428 2870 79583048
Anterior chamber cell 46.75 9.42 27 158443 922 79584996
Extradural haematoma 45.51 9.42 41 158429 2835 79583083
Procedural complication 45.40 9.42 67 158403 7916 79578002
Paraplegia 45.22 9.42 53 158417 5000 79580918
Rheumatic fever 44.88 9.42 3 158467 28522 79557396
Ventricular extrasystoles 44.88 9.42 112 158358 19592 79566326
Drug reaction with eosinophilia and systemic symptoms 44.87 9.42 37 158433 64207 79521711
Removal of foreign body 44.09 9.42 13 158457 69 79585849
Infection susceptibility increased 43.67 9.42 45 158425 3676 79582242
Systolic anterior motion of mitral valve 43.66 9.42 12 158458 47 79585871
Respiratory acidosis 43.34 9.42 79 158391 11121 79574797
Infusion site rash 43.30 9.42 32 158438 1670 79584248
Throat tightness 43.29 9.42 138 158332 27769 79558149
Treatment failure 43.16 9.42 183 158287 170303 79415615
Ventricular arrhythmia 42.97 9.42 69 158401 8771 79577147
Mean arterial pressure decreased 42.94 9.42 19 158451 363 79585555
Purtscher retinopathy 42.58 9.42 14 158456 112 79585806
Spinal cord infarction 42.55 9.42 22 158448 601 79585317
Paralysis 42.46 9.42 86 158384 13091 79572827
Trigemino-cardiac reflex 42.35 9.42 17 158453 252 79585666
Status asthmaticus 42.04 9.42 26 158444 1008 79584910
Aqueous fibrin 41.33 9.42 14 158456 124 79585794
Oedema peripheral 41.01 9.42 313 158157 251975 79333943
C-reactive protein increased 40.94 9.42 126 158344 128901 79457017
Orthostatic hypotension 40.92 9.42 31 158439 56133 79529785
Liver disorder 40.03 9.42 51 158419 72366 79513552
Psoriasis 39.99 9.42 73 158397 89514 79496404
Product adhesion issue 39.77 9.42 37 158433 2667 79583251
Nerve root injury 39.47 9.42 10 158460 26 79585892
Myocardial ischaemia 39.41 9.42 126 158344 25393 79560525
Type I hypersensitivity 39.14 9.42 46 158424 4352 79581566
Cardiac failure congestive 39.11 9.42 148 158322 142254 79443664
Hyperdynamic left ventricle 38.83 9.42 18 158452 385 79585533
Pharyngeal oedema 38.66 9.42 94 158376 16178 79569740
Drug resistance 38.20 9.42 18 158452 42195 79543723
Migraine 38.11 9.42 301 158169 87192 79498726
Ventricular hypokinesia 37.89 9.42 67 158403 9212 79576706
Abdominal pain upper 37.65 9.42 275 158195 223544 79362374
Laryngeal oedema 37.55 9.42 62 158408 8067 79577851
Respiratory distress 37.55 9.42 221 158249 58118 79527800
Eye infection 37.47 9.42 77 158393 11843 79574075
Peripheral swelling 37.29 9.42 349 158121 269268 79316650
Delayed recovery from anaesthesia 37.14 9.42 29 158441 1644 79584274
Blood creatinine increased 37.09 9.42 170 158300 154887 79431031
Lip swelling 36.73 9.42 170 158300 40741 79545177
Medical device site laceration 36.56 9.42 7 158463 0 79585918
Systemic toxicity 36.21 9.42 13 158457 139 79585779
White blood cell count decreased 35.83 9.42 223 158247 188065 79397853
Pharyngeal swelling 35.83 9.42 59 158411 7660 79578258
Blood cholesterol increased 35.80 9.42 70 158400 83650 79502268
Myopathy toxic 35.73 9.42 24 158446 1074 79584844
Retinal vasculitis 35.69 9.42 26 158444 1327 79584591
Anaphylactoid shock 35.26 9.42 21 158449 760 79585158
Procedural haemorrhage 35.06 9.42 45 158425 4661 79581257
Bladder prolapse 34.13 9.42 26 158444 1421 79584497
Inhibitory drug interaction 33.83 9.42 43 158427 4410 79581508
Injection site hypoaesthesia 33.71 9.42 18 158452 526 79585392
Chondromalacia 33.59 9.42 13 158457 174 79585744
Pharyngitis streptococcal 33.43 9.42 69 158401 10645 79575273
Dermatitis contact 33.19 9.42 70 158400 10963 79574955
Fear of eating 33.16 9.42 17 158453 456 79585462
Infusion site discomfort 32.88 9.42 25 158445 1362 79584556
Death 32.81 9.42 866 157604 565648 79020270
Abdominal pain 32.63 9.42 561 157909 389008 79196910
Hepatocellular injury 32.51 9.42 28 158442 47565 79538353
Anal sphincter atony 32.26 9.42 15 158455 323 79585595
Jaundice 32.24 9.42 35 158435 53314 79532604
Uterine hypertonus 32.15 9.42 14 158456 257 79585661
Phrenic nerve paralysis 32.14 9.42 15 158455 326 79585592
Gas gangrene 31.76 9.42 14 158456 265 79585653
Product contamination microbial 31.56 9.42 21 158449 925 79584993
Meningitis chemical 31.09 9.42 13 158457 215 79585703
Stomatitis 31.03 9.42 168 158302 146589 79439329
Corneal reflex decreased 31.01 9.42 15 158455 354 79585564
Confusional state 30.98 9.42 445 158025 317552 79268366
Blood lactic acid increased 30.68 9.42 74 158396 12670 79573248
Melaena 30.53 9.42 46 158424 60844 79525074
Infusion site irritation 30.33 9.42 19 158451 754 79585164
Red blood cell sedimentation rate increased 30.22 9.42 28 158442 45914 79540004
Normal newborn 30.09 9.42 52 158418 7020 79578898
Pulmonary fibrosis 30.07 9.42 26 158444 44086 79541832
Glucose tolerance impaired 30.00 9.42 56 158414 8028 79577890
Peripheral nerve injury 29.15 9.42 18 158452 696 79585222
Gastrointestinal haemorrhage 29.12 9.42 173 158297 147546 79438372
Agranulocytosis 28.96 9.42 28 158442 45002 79540916
Anaphylactoid reaction 28.69 9.42 44 158426 5378 79580540
Status epilepticus 28.63 9.42 112 158358 24929 79560989
Oculocardiac reflex 28.54 9.42 9 158461 62 79585856
Eye inflammation 28.40 9.42 48 158422 6365 79579553
Pancreatitis acute 28.40 9.42 34 158436 49570 79536348
Gastroenteritis viral 28.34 9.42 111 158359 24720 79561198
Platelet aggregation inhibition 28.30 9.42 11 158459 149 79585769
International normalised ratio increased 28.12 9.42 81 158389 84640 79501278
Cytomegalovirus infection 28.03 9.42 26 158444 42618 79543300
Injection site inflammation 28.03 9.42 37 158433 3939 79581979
Constipation 27.95 9.42 395 158075 282655 79303263
Anal inflammation 27.94 9.42 23 158447 1407 79584511
Irritable bowel syndrome 27.52 9.42 51 158419 62190 79523728
Liver function test abnormal 27.49 9.42 54 158416 64421 79521497
Liquid product physical issue 27.48 9.42 21 158449 1153 79584765
Obesity 27.42 9.42 18 158452 35107 79550811
Blister 27.39 9.42 133 158337 119343 79466575
Troponin I increased 27.28 9.42 40 158430 4698 79581220
Cardiotoxicity 27.28 9.42 69 158401 12170 79573748
Neuromuscular blockade 27.24 9.42 16 158454 564 79585354
Tracheal deviation 26.99 9.42 11 158459 170 79585748
Drug-induced liver injury 26.81 9.42 57 158413 66060 79519858
Inflammation 26.68 9.42 96 158374 93657 79492261
Pupil fixed 26.41 9.42 34 158436 3532 79582386
Ischaemia 26.37 9.42 53 158417 8022 79577896
Food allergy 26.22 9.42 63 158407 10761 79575157
Coronary artery disease 26.08 9.42 57 158413 65417 79520501
Prescribed underdose 26.07 9.42 13 158457 29501 79556417
Infusion site nodule 26.05 9.42 13 158457 329 79585589
Blood pH decreased 26.02 9.42 39 158431 4672 79581246
Vasospasm 25.92 9.42 20 158450 1114 79584804
Upper airway obstruction 25.90 9.42 22 158448 1406 79584512
Supraventricular tachycardia 25.85 9.42 97 158373 21173 79564745
Hypercalcaemia 25.78 9.42 23 158447 38407 79547511
Hypoglycaemia 25.73 9.42 109 158361 101485 79484433
Injection site pain 25.57 9.42 381 158089 129457 79456461
Hepatotoxicity 25.55 9.42 39 158431 51313 79534605
Paraesthesia oral 25.42 9.42 94 158376 20377 79565541
Visual acuity reduced 25.39 9.42 121 158349 29348 79556570
Catarrh 24.95 9.42 26 158444 2152 79583766
Electrocardiogram T wave inversion 24.85 9.42 41 158429 5331 79580587
Blindness 24.78 9.42 117 158353 28266 79557652
Extremity necrosis 24.77 9.42 31 158439 3130 79582788
Harlequin syndrome 24.67 9.42 8 158462 61 79585857
Rhinitis 24.61 9.42 75 158395 14732 79571186
Spinal stroke 24.60 9.42 7 158463 32 79585886
Hip arthroplasty 24.47 9.42 21 158449 35735 79550183
Axillary nerve injury 24.45 9.42 6 158464 13 79585905
Coagulation factor deficiency 24.45 9.42 10 158460 156 79585762
Fatigue 24.42 9.42 1557 156913 928170 78657748
Nystagmus 24.37 9.42 58 158412 9846 79576072
Chemical burn 24.34 9.42 15 158455 578 79585340
Spinal cord oedema 24.28 9.42 13 158457 382 79585536
Spinal anaesthesia 24.23 9.42 8 158462 65 79585853
Metastases to liver 24.23 9.42 13 158457 28301 79557617
Coma 24.16 9.42 306 158164 100343 79485575
Inappropriate antidiuretic hormone secretion 24.15 9.42 11 158459 26302 79559616
Accelerated idioventricular rhythm 24.13 9.42 11 158459 226 79585692
Corneal epithelium defect 24.08 9.42 16 158454 703 79585215
Arthritis bacterial 24.00 9.42 55 158415 9111 79576807
Immunisation reaction 23.98 9.42 14 158456 488 79585430
Inappropriate schedule of product administration 23.97 9.42 386 158084 133242 79452676
Familial periodic paralysis 23.94 9.42 10 158460 165 79585753
Product preparation error 23.88 9.42 42 158428 5751 79580167
Dry gangrene 23.83 9.42 18 158452 971 79584947
Hypopnoea 23.75 9.42 40 158430 5289 79580629
Device ineffective 23.72 9.42 10 158460 169 79585749
Skin infection 23.69 9.42 85 158385 18160 79567758
Administration site swelling 23.65 9.42 14 158456 501 79585417
Adverse event 23.51 9.42 53 158417 60161 79525757
Haematochezia 23.47 9.42 92 158378 87553 79498365
Disease recurrence 23.42 9.42 32 158438 44077 79541841
Factor V Leiden mutation 23.19 9.42 10 158460 179 79585739
Product use in unapproved indication 23 9.42 656 157814 249703 79336215
Swelling 22.98 9.42 298 158172 216413 79369505
PCO2 increased 22.95 9.42 23 158447 1817 79584101
Musculoskeletal pain 22.85 9.42 115 158355 102239 79483679
Headache 22.81 9.42 1549 156921 652223 78933695
Hypercapnia 22.72 9.42 53 158417 8882 79577036
Gastrointestinal disorder 22.59 9.42 146 158324 122059 79463859
Burns second degree 22.58 9.42 27 158443 2601 79583317
Steroid dependence 22.57 9.42 27 158443 2603 79583315
Urinary tract infection 22.45 9.42 709 157761 273803 79312115
Myocardial stunning 22.41 9.42 10 158460 195 79585723
Platelet count decreased 22.41 9.42 263 158207 194401 79391517
Weight increased 22.39 9.42 402 158068 276984 79308934
Haemoglobin decreased 22.26 9.42 309 158161 221810 79364108
Hypercholesterolaemia 22.24 9.42 9 158461 23086 79562832
Prostate cancer 22.21 9.42 20 158450 33248 79552670
Atrioventricular block complete 22.09 9.42 78 158392 16532 79569386
Product administration error 22.03 9.42 123 158347 31723 79554195
Rheumatoid nodule 22.02 9.42 4 158466 17434 79568484
Abortion spontaneous 21.86 9.42 16 158454 29491 79556427
Scar 21.64 9.42 73 158397 15123 79570795
PO2 decreased 21.55 9.42 28 158442 2935 79582983
Vasoconstriction 21.49 9.42 15 158455 715 79585203
Product prescribing error 21.38 9.42 35 158435 44778 79541140
Osteonecrosis of jaw 21.34 9.42 33 158437 43193 79542725
Gait inability 21.30 9.42 54 158416 58863 79527055
Eyelid ptosis 21.30 9.42 59 158411 10985 79574933
Hepatitis 21.00 9.42 50 158420 55677 79530241
Balance disorder 20.98 9.42 113 158357 98744 79487174
Lung hyperinflation 20.95 9.42 22 158448 1837 79584081
Fear of death 20.87 9.42 20 158450 1496 79584422
Creatinine renal clearance decreased 20.73 9.42 6 158464 18996 79566922
SARS-CoV-2 test negative 20.63 9.42 19 158451 1352 79584566
Kidney infection 20.50 9.42 92 158378 21759 79564159
Quadriplegia 20.27 9.42 29 158441 3331 79582587
Alanine aminotransferase increased 20.14 9.42 216 158254 162354 79423564
Chills 20.12 9.42 438 158032 159796 79426122
Impaired work ability 20.10 9.42 85 158385 19596 79566322
Poor quality sleep 20.08 9.42 94 158376 22628 79563290
Pneumocystis jirovecii pneumonia 20.01 9.42 21 158449 32487 79553431
Pneumocephalus 19.95 9.42 11 158459 343 79585575
Sensory loss 19.93 9.42 64 158406 12927 79572991
Sinus disorder 19.91 9.42 93 158377 22371 79563547
Progressive multifocal leukoencephalopathy 19.88 9.42 8 158462 20592 79565326
Gamma-glutamyltransferase increased 19.86 9.42 50 158420 54630 79531288
Compartment syndrome 19.86 9.42 36 158434 5046 79580872
Brain oedema 19.82 9.42 101 158369 25162 79560756
Propofol infusion syndrome 19.78 9.42 22 158448 1961 79583957
Respiratory failure 19.77 9.42 485 157985 180426 79405492
Neoplasm progression 19.77 9.42 46 158424 51636 79534282
Rectal prolapse 19.75 9.42 23 158447 2155 79583763
Ill-defined disorder 19.72 9.42 66 158404 65809 79520109
Diabetes mellitus inadequate control 19.53 9.42 12 158458 24252 79561666
Nerve block 19.49 9.42 14 158456 699 79585219
Bursitis infective 19.48 9.42 18 158452 1286 79584632
Weight decreased 19.47 9.42 547 157923 354651 79231267
Reversible cerebral vasoconstriction syndrome 19.35 9.42 27 158443 3030 79582888
Dehydration 19.30 9.42 362 158108 247825 79338093
Sinus bradycardia 19.15 9.42 100 158370 25147 79560771
Atonic urinary bladder 19.08 9.42 7 158463 80 79585838
No adverse event 19.06 9.42 133 158337 37059 79548859
Foreign body 18.98 9.42 26 158444 2868 79583050
Oral herpes 18.97 9.42 106 158364 27348 79558570
Respiratory tract infection bacterial 18.94 9.42 22 158448 2055 79583863
Distributive shock 18.93 9.42 25 158445 2662 79583256
Staphylococcal infection 18.89 9.42 188 158282 58107 79527811
Diabetic ketoacidosis 18.89 9.42 24 158446 34098 79551820
Gastroenteritis 18.84 9.42 24 158446 34058 79551860
Treatment noncompliance 18.83 9.42 48 158422 52220 79533698
Brain injury 18.82 9.42 58 158412 11459 79574459
Parophthalmia 18.77 9.42 11 158459 386 79585532
SARS-CoV-2 test false positive 18.66 9.42 4 158466 3 79585915
Suicide attempt 18.61 9.42 93 158377 82839 79503079
Schizophrenia 18.54 9.42 4 158466 15436 79570482
Respiratory arrest 18.36 9.42 185 158285 57365 79528553
Intracranial hypotension 18.30 9.42 11 158459 405 79585513
Glossoptosis 18.24 9.42 9 158461 222 79585696
Product administered at inappropriate site 17.99 9.42 30 158440 3935 79581983
Arterial spasm 17.93 9.42 8 158462 156 79585762
Foot deformity 17.91 9.42 13 158457 24061 79561857
Apnoeic attack 17.89 9.42 13 158457 661 79585257
Hepatic cirrhosis 17.86 9.42 26 158444 34880 79551038
Premature delivery 17.84 9.42 93 158377 23374 79562544
Myelosuppression 17.83 9.42 33 158437 40263 79545655
Cardio-respiratory arrest 17.83 9.42 309 158161 108201 79477717
Graft versus host disease 17.82 9.42 4 158466 15022 79570896
Transient ischaemic attack 17.76 9.42 50 158420 52645 79533273
Cognitive disorder 17.72 9.42 75 158395 69851 79516067
Palmar-plantar erythrodysaesthesia syndrome 17.63 9.42 24 158446 33110 79552808
Administration site pain 17.61 9.42 12 158458 550 79585368
Discomfort 17.61 9.42 162 158308 125455 79460463
Punctate keratitis 17.49 9.42 15 158455 971 79584947
Pupillary reflex impaired 17.44 9.42 27 158443 3326 79582592
Pancreatic carcinoma 17.39 9.42 3 158467 13574 79572344
Neutropenic sepsis 17.21 9.42 17 158453 27047 79558871
Coagulation factor V level abnormal 17.16 9.42 6 158464 59 79585859
Eyelid oedema 17.12 9.42 63 158407 13624 79572294
Depressed mood 17.09 9.42 45 158425 48435 79537483
Lung neoplasm malignant 17.05 9.42 18 158452 27774 79558144
Postoperative delirium 17.01 9.42 10 158460 353 79585565
Device infusion issue 16.95 9.42 22 158448 2304 79583614
Oxygen saturation decreased 16.92 9.42 355 158115 128692 79457226
Chest discomfort 16.90 9.42 376 158094 137668 79448250
Bone marrow failure 16.86 9.42 49 158421 51058 79534860
Streptococcal infection 16.86 9.42 47 158423 8783 79577135
Neuroleptic malignant syndrome 16.74 9.42 18 158452 27541 79558377
Diabetes insipidus 16.66 9.42 34 158436 5203 79580715
Wheezing 16.65 9.42 325 158145 116339 79469579
Monoplegia 16.64 9.42 29 158441 3942 79581976
Vitamin D increased 16.60 9.42 12 158458 605 79585313
Limb injury 16.57 9.42 108 158362 29420 79556498
Neurotoxicity 16.50 9.42 116 158354 32402 79553516
Heart rate increased 16.45 9.42 334 158136 120390 79465528
Diabetes mellitus 16.42 9.42 90 158380 78300 79507618
Brain stem syndrome 16.22 9.42 14 158456 914 79585004
Postpartum disorder 16.20 9.42 4 158466 9 79585909
Epinephrine increased 16.20 9.42 4 158466 9 79585909
Injection site joint infection 16.17 9.42 5 158465 32 79585886
Irregular breathing 16.09 9.42 11 158459 507 79585411
Rotator cuff syndrome 16.08 9.42 63 158407 14032 79571886
Blood creatine phosphokinase increased 16.07 9.42 72 158398 66018 79519900
Gait disturbance 16.02 9.42 303 158167 207203 79378715
Sinus arrest 15.90 9.42 27 158443 3595 79582323
Aplastic anaemia 15.77 9.42 74 158396 17831 79568087
Poor quality product administered 15.77 9.42 27 158443 3618 79582300
Blood pressure increased 15.75 9.42 540 157930 210820 79375098
Product use issue 15.71 9.42 308 158162 209514 79376404
Drug abuse 15.70 9.42 228 158242 162463 79423455
Application site pallor 15.67 9.42 3 158467 0 79585918
Hypercatabolism 15.67 9.42 3 158467 0 79585918
Airway complication of anaesthesia 15.67 9.42 10 158460 410 79585508
Peripheral venous disease 15.65 9.42 6 158464 15903 79570015
Injection site discharge 15.60 9.42 13 158457 809 79585109
Nasal discharge discolouration 15.56 9.42 22 158448 2499 79583419
Vocal cord disorder 15.52 9.42 17 158453 1489 79584429
Dental restoration failure 15.51 9.42 14 158456 970 79584948
Infusion site reaction 15.28 9.42 26 158444 3467 79582451
Poor venous access 15.26 9.42 74 158396 18075 79567843
Skin test positive 15.25 9.42 15 158455 1159 79584759
Peritonitis 15.23 9.42 20 158450 28016 79557902
Spinal epidural haemorrhage 15.22 9.42 7 158463 147 79585771
Respiratory tract infection viral 15.18 9.42 29 158441 4230 79581688
Macroglossia 15.17 9.42 15 158455 1166 79584752
Application site alopecia 15.13 9.42 4 158466 13 79585905
Amaurosis 15.07 9.42 15 158455 1176 79584742
Phaeochromocytoma crisis 15.05 9.42 9 158461 328 79585590
Muscle tightness 14.96 9.42 58 158412 12856 79573062
Acute pulmonary oedema 14.95 9.42 62 158408 14168 79571750
Lip dry 14.86 9.42 6 158464 15412 79570506
Fall 14.83 9.42 805 157665 486824 79099094
Postresuscitation encephalopathy 14.69 9.42 5 158465 45 79585873
Diplegia 14.64 9.42 18 158452 1785 79584133
Knee arthroplasty 14.61 9.42 41 158429 43207 79542711
Eosinophilia 14.58 9.42 44 158426 45301 79540617
Urticaria chronic 14.54 9.42 11 158459 595 79585323
Retinal vascular occlusion 14.52 9.42 11 158459 596 79585322
Infusion site scar 14.44 9.42 9 158461 354 79585564
Capillary nail refill test abnormal 14.41 9.42 5 158465 48 79585870
Skin ulcer 14.40 9.42 57 158413 54093 79531825
ECG signs of myocardial ischaemia 14.37 9.42 9 158461 357 79585561
Hallucination, auditory 14.35 9.42 12 158458 20681 79565237
Drug tolerance decreased 14.34 9.42 4 158466 12974 79572944
Catecholamine crisis 14.32 9.42 5 158465 49 79585869
Torsade de pointes 14.31 9.42 76 158394 19236 79566682
Epidural analgesia 14.23 9.42 5 158465 50 79585868
Heparin-induced thrombocytopenia 14.22 9.42 47 158423 9635 79576283
Seizure like phenomena 14.14 9.42 18 158452 1849 79584069
Blood pressure fluctuation 14.11 9.42 77 158393 67068 79518850
Anion gap increased 14.09 9.42 26 158444 3694 79582224
Pneumonia mycoplasmal 14.06 9.42 16 158454 1462 79584456
Parosmia 14.05 9.42 38 158432 6976 79578942
Angina pectoris 14.04 9.42 54 158416 51678 79534240
Hypomagnesaemia 14.04 9.42 47 158423 46864 79539054
Hepatitis cholestatic 14 9.42 5 158465 13847 79572071
Accident 14.00 9.42 44 158426 8787 79577131
Immune reconstitution inflammatory syndrome 13.98 9.42 5 158465 13836 79572082
Laryngospasm 13.98 9.42 27 158443 3970 79581948
Bladder cancer 13.94 9.42 11 158459 19515 79566403
SARS-CoV-2 test positive 13.88 9.42 53 158417 11663 79574255
Neurogenic shock 13.85 9.42 11 158459 639 79585279
Arthritis infective 13.84 9.42 42 158428 8229 79577689
Incision site rash 13.77 9.42 4 158466 20 79585898
Trigeminal palsy 13.77 9.42 4 158466 20 79585898
Tracheitis 13.70 9.42 15 158455 1313 79584605
Hallucination 13.62 9.42 107 158363 85638 79500280
Meningitis 13.62 9.42 46 158424 9536 79576382
Caffeine allergy 13.60 9.42 4 158466 21 79585897
Implant site bruising 13.60 9.42 8 158462 283 79585635
Nerve root injury cervical 13.60 9.42 3 158467 3 79585915
Removal of foreign body from throat 13.60 9.42 3 158467 3 79585915
Ascites 13.59 9.42 91 158379 75471 79510447
Cranial nerve palsies multiple 13.59 9.42 6 158464 114 79585804
Viral infection 13.59 9.42 138 158332 42878 79543040
Blindness cortical 13.55 9.42 13 158457 974 79584944
Enzyme induction 13.54 9.42 6 158464 115 79585803
Lymphopenia 13.54 9.42 25 158445 30532 79555386
Oropharyngeal discomfort 13.54 9.42 38 158432 7128 79578790
Cholestasis of pregnancy 13.48 9.42 13 158457 980 79584938
Ventricular tachyarrhythmia 13.43 9.42 9 158461 401 79585517
Anion gap 13.42 9.42 19 158451 2162 79583756
Mental status changes 13.38 9.42 197 158273 66762 79519156
Hyperkalaemia 13.37 9.42 154 158316 114244 79471674
Haematuria 13.36 9.42 81 158389 68755 79517163
Nail bed tenderness 13.35 9.42 9 158461 405 79585513
Polyneuropathy 13.35 9.42 17 158453 24134 79561784
Drug level decreased 13.25 9.42 6 158464 14396 79571522
Product distribution issue 13.23 9.42 15 158455 1365 79584553
Proteinuria 13.19 9.42 28 158442 32474 79553444
Hepatic function abnormal 13.17 9.42 88 158382 73019 79512899
Condition aggravated 13.14 9.42 839 157631 500285 79085633
Atrophy of globe 13.12 9.42 5 158465 64 79585854
Haemorrhoids 13.12 9.42 101 158369 29027 79556891
Renal cancer 13.08 9.42 4 158466 12222 79573696
Polyarthritis 13.04 9.42 4 158466 12198 79573720
Pupillary light reflex tests abnormal 13.01 9.42 8 158462 307 79585611
Myopathy 12.98 9.42 13 158457 20550 79565368
Product preparation issue 12.97 9.42 15 158455 1395 79584523
Vaccination complication 12.94 9.42 12 158458 861 79585057
Cardiac failure 12.93 9.42 223 158247 154619 79431299
Laryngeal obstruction 12.91 9.42 6 158464 129 79585789
Brown-Sequard syndrome 12.91 9.42 5 158465 67 79585851
Mast cell activation syndrome 12.87 9.42 11 158459 709 79585209
Joint stiffness 12.85 9.42 40 158430 40790 79545128
Loss of personal independence in daily activities 12.82 9.42 136 158334 102444 79483474
Disseminated intravascular coagulation 12.80 9.42 118 158352 35724 79550194
Cardiopulmonary failure 12.79 9.42 36 158434 6765 79579153
Therapeutic product effect prolonged 12.77 9.42 10 158460 569 79585349
Air embolism 12.73 9.42 9 158461 438 79585480
Vascular resistance systemic decreased 12.70 9.42 7 158463 218 79585700
Procedural pain 12.69 9.42 84 158386 23000 79562918
Myocardial necrosis marker increased 12.69 9.42 23 158447 3223 79582695
Myocardial infarction 12.68 9.42 274 158196 183855 79402063
Pharyngitis 12.66 9.42 82 158388 22293 79563625
Injection site nerve damage 12.65 9.42 5 158465 71 79585847
Catheter site pain 12.63 9.42 31 158439 5365 79580553
Neuropathy peripheral 12.62 9.42 201 158269 141104 79444814
Dermatitis exfoliative 12.61 9.42 3 158467 10826 79575092
Inability to afford medication 12.61 9.42 21 158449 2752 79583166
Paranasal cyst 12.59 9.42 9 158461 446 79585472
Insomnia 12.56 9.42 381 158089 244789 79341129
Exposure during pregnancy 12.55 9.42 276 158194 100856 79485062
Oxidative stress 12.51 9.42 4 158466 29 79585889
Anaesthetic complication cardiac 12.40 9.42 5 158465 75 79585843
Injection site necrosis 12.40 9.42 15 158455 1463 79584455
Eye infection intraocular 12.39 9.42 4 158466 30 79585888
Forced vital capacity abnormal 12.39 9.42 4 158466 30 79585888
Myelodysplastic syndrome 12.38 9.42 26 158444 30275 79555643
Device malfunction 12.38 9.42 79 158391 21369 79564549
Hypocalcaemia 12.37 9.42 54 158416 49870 79536048
Inadequate analgesia 12.37 9.42 28 158442 4601 79581317
Autonomic nervous system imbalance 12.36 9.42 28 158442 4602 79581316
Sedation 12.34 9.42 57 158413 51838 79534080
Blood alkaline phosphatase increased 12.31 9.42 75 158395 63589 79522329
Post lumbar puncture syndrome 12.29 9.42 11 158459 754 79585164
Infection 12.29 9.42 376 158094 241336 79344582
Bradyphrenia 12.29 9.42 3 158467 10637 79575281
Procedural anxiety 12.28 9.42 11 158459 755 79585163
Left ventricular dysfunction 12.23 9.42 73 158397 19288 79566630
Allergic reaction to excipient 12.19 9.42 8 158462 344 79585574
Retinal haemorrhage 12.17 9.42 40 158430 8177 79577741
Mania 12.16 9.42 11 158459 18249 79567669
Optic atrophy 12.13 9.42 17 158453 1916 79584002
Dry mouth 12.12 9.42 114 158356 87905 79498013
Fluid retention 12.10 9.42 85 158385 69724 79516194
Tenosynovitis 12.10 9.42 8 158462 15546 79570372
Hepatic cancer 12.10 9.42 3 158467 10526 79575392
Optic nerve injury 12.09 9.42 10 158460 616 79585302
Intentional product use issue 12.09 9.42 221 158249 151891 79434027
Enthesopathy 12.06 9.42 4 158466 11604 79574314
Osteoarthritis 12.06 9.42 113 158357 87196 79498722
Long QT syndrome congenital 12.05 9.42 6 158464 151 79585767
Exophthalmos 12.04 9.42 16 158454 1714 79584204
Pain in jaw 12.00 9.42 49 158421 46102 79539816
Nodal rhythm 11.99 9.42 22 158448 3113 79582805
Abnormal behaviour 11.95 9.42 35 158435 36386 79549532
Pallor 11.92 9.42 152 158318 49910 79536008
Hypophagia 11.91 9.42 48 158422 45319 79540599
Tooth infection 11.89 9.42 71 158399 18761 79567157
Ocular retrobulbar haemorrhage 11.87 9.42 6 158464 156 79585762
Central venous catheter removal 11.84 9.42 9 158461 490 79585428
Injury corneal 11.83 9.42 5 158465 85 79585833
Post transplant lymphoproliferative disorder 11.82 9.42 4 158466 11460 79574458
Breast cancer female 11.82 9.42 4 158466 11457 79574461
Conjunctival oedema 11.81 9.42 13 158457 1145 79584773
Oral pruritus 11.75 9.42 19 158451 2429 79583489
Vitreous disorder 11.74 9.42 7 158463 254 79585664
Mucosal inflammation 11.69 9.42 95 158375 75485 79510433
Second primary malignancy 11.69 9.42 7 158463 14343 79571575
Lung disorder 11.68 9.42 103 158367 80454 79505464
Thermal burn 11.65 9.42 36 158434 7124 79578794
Cardiac assistance device user 11.62 9.42 5 158465 89 79585829
Panniculitis 11.62 9.42 5 158465 12366 79573552
Rhabdomyolysis 11.60 9.42 140 158330 102991 79482927
Pain in extremity 11.59 9.42 599 157871 363939 79221979
Tuberculosis 11.58 9.42 8 158462 15190 79570728
Foetal heart rate abnormal 11.56 9.42 8 158462 376 79585542
Product contamination physical 11.53 9.42 6 158464 166 79585752
Therapeutic product effect incomplete 11.50 9.42 205 158265 141440 79444478
Injection site scar 11.49 9.42 11 158459 822 79585096
Grip strength decreased 11.47 9.42 16 158454 21853 79564065
Intentional product misuse to child 11.47 9.42 5 158465 92 79585826
End-tidal CO2 decreased 11.47 9.42 4 158466 39 79585879
Quadriparesis 11.46 9.42 23 158447 3478 79582440
Hypoventilation 11.46 9.42 36 158434 7188 79578730
Erythema 11.43 9.42 548 157922 222742 79363176
BRASH syndrome 11.40 9.42 12 158458 1005 79584913
Femoral nerve injury 11.38 9.42 4 158466 40 79585878
Fungal infection 11.36 9.42 130 158340 41618 79544300
Immunodeficiency 11.35 9.42 16 158454 21752 79564166
Sinus operation 11.32 9.42 19 158451 2506 79583412
XIIth nerve injury 11.29 9.42 3 158467 10 79585908
Rash 11.23 9.42 993 157477 577365 79008553
Tympanoplasty 11.21 9.42 4 158466 42 79585876
Intraocular pressure increased 11.20 9.42 42 158428 9163 79576755
Oesophageal carcinoma 11.20 9.42 4 158466 11080 79574838
Bundle branch block left 11.20 9.42 49 158421 11464 79574454
Mastocytosis 11.18 9.42 9 158461 533 79585385
Foreign body in respiratory tract 11.18 9.42 8 158462 397 79585521
Opisthotonus 11.17 9.42 10 158460 686 79585232
Spinal epidural haematoma 11.15 9.42 14 158456 1418 79584500
Histamine level increased 11.14 9.42 5 158465 99 79585819
Post-anoxic myoclonus 11.12 9.42 4 158466 43 79585875
Areflexia 11.11 9.42 30 158440 5504 79580414
Bronchopulmonary aspergillosis allergic 11.10 9.42 21 158449 3040 79582878
Allodynia 11.10 9.42 15 158455 1633 79584285
Corneal abrasion 11.09 9.42 13 158457 1226 79584692
Infusion site haematoma 11.08 9.42 7 158463 282 79585636
Splenomegaly 11.07 9.42 15 158455 20739 79565179
Transaminases increased 11.06 9.42 59 158411 51684 79534234
Vaginal abscess 11.05 9.42 8 158462 404 79585514
Respiratory tract oedema 11.04 9.42 11 158459 863 79585055
Anaphylactoid syndrome of pregnancy 11.04 9.42 4 158466 44 79585874
Infusion site warmth 10.97 9.42 14 158456 1441 79584477
Lupus-like syndrome 10.95 9.42 7 158463 13850 79572068
Product contamination 10.92 9.42 13 158457 1247 79584671
Injection site atrophy 10.90 9.42 8 158462 413 79585505
Suicidal ideation 10.89 9.42 98 158372 76242 79509676
Renal failure 10.88 9.42 496 157974 200472 79385446
Administration site discolouration 10.87 9.42 3 158467 12 79585906
Electrocardiogram ST-T segment depression 10.87 9.42 3 158467 12 79585906
Proctalgia 10.85 9.42 44 158426 9957 79575961
Reperfusion arrhythmia 10.84 9.42 7 158463 293 79585625
Orbital oedema 10.80 9.42 8 158462 419 79585499
Tongue pruritus 10.79 9.42 9 158461 561 79585357
Chronic kidney disease 10.77 9.42 82 158388 66072 79519846
Incision site swelling 10.75 9.42 7 158463 297 79585621
Colour blindness 10.75 9.42 8 158462 422 79585496
Cholangitis 10.74 9.42 6 158464 12770 79573148
Device expulsion 10.73 9.42 22 158448 25839 79560079
Malaise 10.73 9.42 833 157637 489036 79096882
Autoimmune hepatitis 10.70 9.42 5 158465 11778 79574140
Colitis microscopic 10.69 9.42 4 158466 10764 79575154
Victim of spousal abuse 10.67 9.42 3 158467 13 79585905
Symblepharon 10.66 9.42 6 158464 195 79585723
Intra-ocular injection complication 10.65 9.42 4 158466 49 79585869
Inflammatory marker increased 10.65 9.42 4 158466 10736 79575182
Heliotrope rash 10.63 9.42 6 158464 196 79585722
Cold urticaria 10.57 9.42 5 158465 112 79585806
Photosensitivity reaction 10.55 9.42 16 158454 21111 79564807
Hepatic cytolysis 10.52 9.42 24 158446 27127 79558791
Product measured potency issue 10.49 9.42 6 158464 201 79585717
Peritonitis bacterial 10.47 9.42 3 158467 9564 79576354
Croup infectious 10.46 9.42 10 158460 746 79585172
Myoclonic epilepsy 10.44 9.42 16 158454 1954 79583964
Diplopia 10.40 9.42 107 158363 33359 79552559
Lip disorder 10.39 9.42 14 158456 1520 79584398
Mouth swelling 10.38 9.42 31 158439 6020 79579898
Spinal operation 10.38 9.42 37 158433 7880 79578038
Postural orthostatic tachycardia syndrome 10.37 9.42 11 158459 929 79584989
Swelling face 10.37 9.42 199 158271 71013 79514905
Body dysmorphic disorder 10.33 9.42 7 158463 318 79585600
Coccygectomy 10.32 9.42 3 158467 15 79585903
Tubulointerstitial nephritis 10.32 9.42 40 158430 38195 79547723
Infusion site induration 10.31 9.42 12 158458 1123 79584795
Unwanted awareness during anaesthesia 10.31 9.42 7 158463 319 79585599
Local reaction 10.29 9.42 9 158461 598 79585320
Lower limb fracture 10.28 9.42 19 158451 23196 79562722
Myokymia 10.26 9.42 5 158465 120 79585798
Cold sweat 10.25 9.42 68 158402 18631 79567287
Premature baby 10.25 9.42 23 158447 3757 79582161
Administration site pruritus 10.24 9.42 4 158466 55 79585863
Non-infectious endophthalmitis 10.21 9.42 7 158463 324 79585594
Troponin T increased 10.20 9.42 22 158448 3500 79582418
Vocal cord dysfunction 10.19 9.42 9 158461 606 79585312
Acute respiratory distress syndrome 10.16 9.42 133 158337 43934 79541984
Full blood count decreased 10.15 9.42 24 158446 26795 79559123
Type IV hypersensitivity reaction 10.15 9.42 24 158446 4057 79581861
Retinal ischaemia 10.11 9.42 10 158460 778 79585140
Metastases to lymph nodes 10.09 9.42 4 158466 10393 79575525
Device issue 10.07 9.42 90 158380 27018 79558900
Drug interaction 10.05 9.42 700 157770 414483 79171435
Benign vulval neoplasm 10.04 9.42 4 158466 58 79585860
Injection site oedema 10.04 9.42 13 158457 1358 79584560
pH body fluid abnormal 10.04 9.42 5 158465 126 79585792
Anal skin tags 10.01 9.42 8 158462 469 79585449
Larynx irritation 10.00 9.42 5 158465 127 79585791
Anal ulcer 9.99 9.42 13 158457 1365 79584553
Complex regional pain syndrome 9.97 9.42 16 158454 2032 79583886
Obstructive airways disorder 9.97 9.42 101 158369 31358 79554560
Facet joint syndrome 9.95 9.42 5 158465 11297 79574621
Concomitant disease aggravated 9.94 9.42 7 158463 13160 79572758
Electrocardiogram U wave present 9.89 9.42 5 158465 130 79585788
Influenza 9.87 9.42 332 158138 129274 79456644
Product confusion 9.87 9.42 3 158467 18 79585900
Blood glucose increased 9.79 9.42 165 158305 114810 79471108
Sleep disorder 9.76 9.42 116 158354 85561 79500357
Nephropathy toxic 9.69 9.42 16 158454 20403 79565515
Adjustment disorder with depressed mood 9.67 9.42 3 158467 9083 79576835
Corneal opacity 9.63 9.42 11 158459 1009 79584909
Cerebral haemorrhage 9.62 9.42 71 158399 57602 79528316
Vitreous floaters 9.59 9.42 34 158436 7222 79578696
Oesophageal obstruction 9.58 9.42 11 158459 1015 79584903
Serum amyloid A protein increased 9.58 9.42 7 158463 359 79585559
Incorrect product formulation administered 9.56 9.42 5 158465 140 79585778
Neuralgia 9.56 9.42 105 158365 33279 79552639
Arrhythmia 9.53 9.42 173 158297 61099 79524819
Drainage 9.52 9.42 5 158465 141 79585777
Intraocular pressure fluctuation 9.52 9.42 4 158466 67 79585851
Sudden death 9.47 9.42 19 158451 22492 79563426
Toxic epidermal necrolysis 9.43 9.42 51 158419 44530 79541388
Multiple sclerosis relapse 9.43 9.42 54 158416 46479 79539439

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 32.77 29.15 10 151 71 89560
Cardiac arrest neonatal 31.31 29.15 10 151 84 89547

Pharmacologic Action:

SourceCodeDescription
ATC A01AD01 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Other agents for local oral treatment
ATC B02BC09 BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
VITAMIN K AND OTHER HEMOSTATICS
Local hemostatics
ATC C01CA24 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
ATC R01AA14 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, plain
ATC R03AA01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Alpha- and beta-adrenoreceptor agonists
ATC R03AK01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC S01EA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Sympathomimetics in glaucoma therapy
ATC S01EA51 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Sympathomimetics in glaucoma therapy
FDA CS M0003647 Catecholamines
FDA MoA N0000000209 Adrenergic alpha-Agonists
FDA MoA N0000000245 Adrenergic beta-Agonists
FDA EPC N0000175552 alpha-Adrenergic Agonist
FDA EPC N0000175555 beta-Adrenergic Agonist
FDA EPC N0000175570 Catecholamine
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D009184 Mydriatics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents
CHEBI has role CHEBI:24621 hormones
CHEBI has role CHEBI:35522 beta-adrenergic agonists
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:35569 alpha-adrenergic agonists
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:37886 adrenergic agonists
CHEBI has role CHEBI:50513 mydriatics
CHEBI has role CHEBI:75771 Mus musculus metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchiectasis indication 12295008 DOID:9563
Bronchitis indication 32398004 DOID:6132
Anaphylaxis indication 39579001
Local anesthesia, by infiltration indication 44596000
Low blood pressure indication 45007003
Wheezing indication 56018004
Hypotension associated with septic shock indication 76571007
Open-angle glaucoma indication 84494001 DOID:1067
Pulmonary emphysema indication 87433001
Dyspnea indication 267036007
Exacerbation of asthma indication 281239006
Asthma management indication 406162001
Acute exacerbation of asthma indication 708038006
Administration of Local Anesthetic Nerve Block indication
Allergic Reactions indication
Ventricular fibrillation off-label use 71908006
Asthma off-label use 195967001 DOID:2841
Local anesthesia off-label use 386761002
Cardiac arrest off-label use 410429000 DOID:0060319
Keratitis contraindication 5888003 DOID:4677
Bacterial septicemia contraindication 10001005 DOID:0040085
Sinus tachycardia contraindication 11092001
Myocardial infarction contraindication 22298006 DOID:5844
Aphakia contraindication 24010005
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Hypovolemia contraindication 28560003
Hypercapnia contraindication 29596007
Parkinsonism contraindication 32798002
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Retinal detachment contraindication 42059000 DOID:5327
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Stokes-Adams syndrome contraindication 46935006
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Atrial fibrillation contraindication 49436004 DOID:0060224
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Sinus bradycardia contraindication 49710005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Iritis contraindication 65074000 DOID:1406
Cerebral arteriosclerosis contraindication 65312002
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Decreased respiratory function contraindication 80954004
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Bleeding contraindication 131148009
Angina pectoris contraindication 194828000
Primary dilated cardiomyopathy contraindication 195021004
Partial atrioventricular block contraindication 195039008
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Sepsis syndrome contraindication 238150007
Benign prostatic hyperplasia contraindication 266569009
Psychoneurotic personality disorder contraindication 268634009
Deficiency of cholinesterase contraindication 360607009
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Peripheral vascular disease contraindication 400047006
Anterior uveitis contraindication 410692006 DOID:1407
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Denuded skin contraindication 418242004
Thrombosis contraindication 439127006
Pupillary Block Glaucoma contraindication
Occlusive Vascular Disease contraindication
Lidocaine Toxicity contraindication
Regional Anesthesia for Labor Pain contraindication
Reduced Hepatic Blood Flow contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.97 acidic
pKa2 12.82 acidic
pKa3 13.64 acidic
pKa4 8.71 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 0.1MG/DELIVERY AUVI-Q KALEO INC N201739 Nov. 17, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 9833573 Nov. 23, 2024 METHOD TO TREAT SEVERE ALLERGIC EMERGENCIES IN PATIENTS WEIGHING 7.5 TO 15 KG (16.5 TO 33 LBS)
EQ 0.15MG/DELIVERY AUVI-Q KALEO INC N201739 Aug. 10, 2012 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 9149579 July 19, 2025 METHOD OF TREATING ALLERGIC REACTION VIA INJECTION
EQ 0.1MG/DELIVERY AUVI-Q KALEO INC N201739 Nov. 17, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 9149579 July 19, 2025 METHOD OF TREATING ALLERGIC REACTION VIA INJECTION
EQ 0.3MG/DELIVERY AUVI-Q KALEO INC N201739 Aug. 10, 2012 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 9149579 July 19, 2025 METHOD OF TREATING ALLERGIC REACTION VIA INJECTION
EQ 0.15MG/DELIVERY AUVI-Q KALEO INC N201739 Aug. 10, 2012 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 9724471 May 23, 2027 METHOD FOR CONFIRMING DOSE DELIVERY
EQ 0.1MG/DELIVERY AUVI-Q KALEO INC N201739 Nov. 17, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 9724471 May 23, 2027 METHOD FOR CONFIRMING DOSE DELIVERY
EQ 0.3MG/DELIVERY AUVI-Q KALEO INC N201739 Aug. 10, 2012 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 9724471 May 23, 2027 METHOD FOR CONFIRMING DOSE DELIVERY
1MG/ML (1MG/ML) EPINEPHRINE BPI LABS N205029 July 29, 2014 RX SOLUTION INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS 10004700 Aug. 14, 2034 EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE 1), INCLUDING ANAPHYLAXIS; A METHOD OF TREATING ALLERGIC REACTION, ANAPHYLAXIS, ANAPHYLACTIC SHOCK, OR COMBINATION THEREOF BY AN INJECTION OF AT LEAST ONE DOSAGE OF THE INJECTABLE LIQUID PHARMACEUTICAL
1MG/ML (1MG/ML) EPINEPHRINE BPI LABS N205029 July 29, 2014 RX SOLUTION INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS 10039728 Aug. 14, 2034 INCREASING MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
1MG/ML (1MG/ML) EPINEPHRINE BPI LABS N205029 July 29, 2014 RX SOLUTION INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS 9283197 Aug. 15, 2034 EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
1MG/ML (1MG/ML) EPINEPHRINE BPI LABS N205029 July 29, 2014 RX SOLUTION INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS 9283197 Aug. 15, 2034 INCREASING MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
1MG/ML (1MG/ML) EPINEPHRINE BPI LABS N205029 July 29, 2014 RX SOLUTION INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS 9283197 Aug. 15, 2034 INDUCTION AND MAINTENANCE OF MYDRIASIS DURING INTRAOCULAR SURGERY
EQ 1MG BASE/ML (EQ 1MG BASE/ML) ADRENALIN PAR STERILE PRODUCTS N204200 Dec. 7, 2012 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS 9295657 March 13, 2035 EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
EQ 30MG BASE/30ML (EQ 1MG BASE/ML) ADRENALIN PAR STERILE PRODUCTS N204640 Dec. 18, 2013 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS 9295657 March 13, 2035 EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
0.15MG/0.3ML (0.15MG/0.3ML) SYMJEPI ADAMIS PHARMS CORP N207534 Sept. 27, 2018 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 11141540 Oct. 20, 2036 A METHOD FOR ADMINISTERING A THERAPEUTIC DOSE OF EPINEPHRINE
0.3MG/0.3ML (0.3MG/0.3ML) SYMJEPI ADAMIS PHARMS CORP N207534 June 15, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 11141540 Oct. 20, 2036 A METHOD FOR ADMINISTERING A THERAPEUTIC DOSE OF EPINEPHRINE
EQ 0.15MG/DELIVERY AUVI-Q KALEO INC N201739 Aug. 10, 2012 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 10688244 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
EQ 0.15MG/DELIVERY AUVI-Q KALEO INC N201739 Aug. 10, 2012 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 10842938 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
EQ 0.1MG/DELIVERY AUVI-Q KALEO INC N201739 Nov. 17, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 10688244 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
EQ 0.1MG/DELIVERY AUVI-Q KALEO INC N201739 Nov. 17, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 10842938 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
10MG/250ML (40MCG/ML) EPINEPHRINE IN 0.9% SODIUM CHLORIDE PAR STERILE PRODUCTS N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
2MG/250ML (8MCG/ML) EPINEPHRINE IN 0.9% SODIUM CHLORIDE PAR STERILE PRODUCTS N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
4MG/250ML (16MCG/ML) EPINEPHRINE IN 0.9% SODIUM CHLORIDE PAR STERILE PRODUCTS N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
5MG/250ML (20MCG/ML) EPINEPHRINE IN 0.9% SODIUM CHLORIDE PAR STERILE PRODUCTS N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
8MG/250ML (32MCG/ML) EPINEPHRINE IN 0.9% SODIUM CHLORIDE PAR STERILE PRODUCTS N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-1D adrenergic receptor GPCR AGONIST Ki 6.66 CHEMBL CHEMBL
Alpha-1B adrenergic receptor GPCR AGONIST Ki 6.50 IUPHAR CHEMBL
Alpha-2A adrenergic receptor GPCR AGONIST Ki 6.56 DRUG MATRIX CHEMBL
Beta-2 adrenergic receptor GPCR AGONIST Kd 6.20 CHEMBL CHEMBL
Alpha-1A adrenergic receptor GPCR AGONIST Ki 5.70 CHEMBL CHEMBL
Alpha-2B adrenergic receptor GPCR AGONIST Ki 6.40 DRUG MATRIX CHEMBL
Alpha-2C adrenergic receptor GPCR AGONIST Ki 6.45 DRUG MATRIX CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.40 PDSP
D(1A) dopamine receptor GPCR Kd 4.26 CHEMBL
D(2) dopamine receptor GPCR Ki 6.04 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.43 PDSP
Alpha-1D adrenergic receptor GPCR AGONIST Ki 6.30 IUPHAR
Mu-type opioid receptor GPCR Ki 5.40 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.96 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.18 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.14 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.52 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.89 CHEMBL
Adrenergic receptor beta GPCR IC50 4.54 CHEMBL
M18 aspartyl aminopeptidase Enzyme IC50 5.52 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 5.48 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.01 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 6.20 CHEMBL

External reference:

IDSource
4018034 VUID
N0000146377 NUI
D00996 KEGG_DRUG
51-42-3 SECONDARY_CAS_RN
4018032 VANDF
4018033 VANDF
4018034 VANDF
C0014563 UMLSCUI
CHEBI:28918 CHEBI
CHEMBL679 ChEMBL_ID
DB00668 DRUGBANK_ID
CHEMBL1256958 ChEMBL_ID
D004837 MESH_DESCRIPTOR_UI
5816 PUBCHEM_CID
2142 INN_ID
55-31-2 SECONDARY_CAS_RN
YKH834O4BH UNII
203180 RXNORM
3451 MMSL
3500 MMSL
4663 MMSL
4664 MMSL
4665 MMSL
4667 MMSL
72412 MMSL
d00699 MMSL
001774 NDDF
001776 NDDF
006223 NDDF
126134000 SNOMEDCT_US
387362001 SNOMEDCT_US
50685004 SNOMEDCT_US
65502005 SNOMEDCT_US
ALE PDB_CHEM_ID
CHEMBL3183376 ChEMBL_ID
479 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5985 INJECTION 0.15 mg INTRAMUSCULAR ANDA 24 sections
Epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5986 INJECTION 0.30 mg INTRAMUSCULAR ANDA 24 sections
epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1694 INJECTION 0.30 mg SUBCUTANEOUS NDA AUTHORIZED GENERIC 25 sections
epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1694 INJECTION 0.30 mg SUBCUTANEOUS NDA AUTHORIZED GENERIC 25 sections
epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1695 INJECTION 0.15 mg SUBCUTANEOUS NDA AUTHORIZED GENERIC 25 sections
epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1695 INJECTION 0.15 mg SUBCUTANEOUS NDA AUTHORIZED GENERIC 25 sections
LIDOCAINE HCl and EPINEPHRINE HUMAN PRESCRIPTION DRUG LABEL 2 0264-9378 INJECTION 0.01 mg EPIDURAL ANDA 12 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0262 INJECTION, SOLUTION 0.02 mg SUBCUTANEOUS ANDA 23 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0262 INJECTION, SOLUTION 0.02 mg SUBCUTANEOUS ANDA 23 sections
Marcaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0557 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 19 sections
Zorcaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0830 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS NDA 29 sections
Zorcaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0830 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS NDA 29 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0898 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 23 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0898 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 23 sections
Lignospan Standard HUMAN PRESCRIPTION DRUG LABEL 2 0362-1095 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 23 sections
Lignospan Standard HUMAN PRESCRIPTION DRUG LABEL 2 0362-1095 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 23 sections
Lignospan Forte HUMAN PRESCRIPTION DRUG LABEL 2 0362-1096 INJECTION, SOLUTION 0.02 mg SUBCUTANEOUS ANDA 23 sections
Lignospan Forte HUMAN PRESCRIPTION DRUG LABEL 2 0362-1096 INJECTION, SOLUTION 0.02 mg SUBCUTANEOUS ANDA 23 sections
Octocaine 50 HUMAN PRESCRIPTION DRUG LABEL 2 0362-9010 INJECTION, SOLUTION 0.02 mg SUBCUTANEOUS ANDA 24 sections
Vivacaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-9011 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 19 sections
Vivacaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-9011 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 19 sections
Vivacaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-9011 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 19 sections
Prilocaine Hydrochloride with Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0362-9013 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 24 sections
Octocaine 100 HUMAN PRESCRIPTION DRUG LABEL 2 0362-9023 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 24 sections
Septocaine and Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0362-9048 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS NDA 29 sections
Septocaine and Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0362-9049 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS NDA 29 sections
LIDOCAINE HUMAN PRESCRIPTION DRUG LABEL 2 0404-6500 INJECTION, SOLUTION 0.02 mg SUBCUTANEOUS ANDA 24 sections
LIDOCAINE HUMAN PRESCRIPTION DRUG LABEL 2 0404-6500 INJECTION, SOLUTION 0.02 mg SUBCUTANEOUS ANDA 24 sections
LIDOCAINE HUMAN PRESCRIPTION DRUG LABEL 2 0404-6500 INJECTION, SOLUTION 0.02 mg SUBCUTANEOUS ANDA 24 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 2 0404-6512 INJECTION, SOLUTION 0.01 mg SUBCUTANEOUS ANDA 24 sections