Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory agents, ibuprofen derivatives | 833 | 22161-81-5 |
Dose | Unit | Route |
---|---|---|
75 | mg | O |
75 | mg | P |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Tubulointerstitial nephritis | 67.03 | 35.07 | 22 | 1311 | 16643 | 56274091 |
Hyperbilirubinaemia | 55.61 | 35.07 | 17 | 1316 | 10218 | 56280516 |
Drug interaction | 55.33 | 35.07 | 43 | 1290 | 209712 | 56081022 |
Angioedema | 53.90 | 35.07 | 24 | 1309 | 41429 | 56249305 |
Lichen planus | 48.27 | 35.07 | 11 | 1322 | 2131 | 56288603 |
Anaphylactic reaction | 37.46 | 35.07 | 21 | 1312 | 58974 | 56231760 |
Acute kidney injury | 36.39 | 35.07 | 36 | 1297 | 240727 | 56050007 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyperaesthesia | 58.98 | 34.67 | 15 | 867 | 3936 | 31692526 |
Quality of life decreased | 46.10 | 34.67 | 12 | 870 | 3443 | 31693019 |
Acute kidney injury | 39.00 | 34.67 | 43 | 839 | 279671 | 31416791 |
Hyperkalaemia | 37.77 | 34.67 | 23 | 859 | 64328 | 31632134 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyperbilirubinaemia | 67.82 | 29.09 | 26 | 2263 | 22542 | 70903613 |
Acute kidney injury | 66.82 | 29.09 | 79 | 2210 | 474545 | 70451610 |
Angioedema | 56.76 | 29.09 | 32 | 2257 | 66578 | 70859577 |
Tubulointerstitial nephritis | 51.89 | 29.09 | 24 | 2265 | 33052 | 70893103 |
Drug interaction | 51.09 | 29.09 | 62 | 2227 | 381379 | 70544776 |
Hepatic cytolysis | 43.34 | 29.09 | 18 | 2271 | 19174 | 70906981 |
Hyperaesthesia | 41.64 | 29.09 | 15 | 2274 | 10927 | 70915228 |
Hepatitis cholestatic | 39.51 | 29.09 | 15 | 2274 | 12635 | 70913520 |
Quality of life decreased | 37.48 | 29.09 | 13 | 2276 | 8482 | 70917673 |
Lichen planus | 33.40 | 29.09 | 9 | 2280 | 2526 | 70923629 |
Hyperkalaemia | 32.19 | 29.09 | 27 | 2262 | 106564 | 70819591 |
Bradyphrenia | 31.81 | 29.09 | 12 | 2277 | 9934 | 70916221 |
Polyneuropathy in malignant disease | 29.39 | 29.09 | 5 | 2284 | 155 | 70926000 |
Fracture displacement | 29.33 | 29.09 | 7 | 2282 | 1211 | 70924944 |
None
Source | Code | Description |
---|---|---|
ATC | M01AE17 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
ATC | M02AA27 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
ATC | N02AJ14 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
CHEBI has role | CHEBI:50629 | COX-2 inhibitor |
CHEBI has role | CHEBI:50630 | COX-1 inhibitor |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.28 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 7.57 | CHEMBL | KEGG DRUG | |||
Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 8.72 | CHEMBL | KEGG DRUG |
ID | Source |
---|---|
6KD9E78X68 | UNII |
D07269 | KEGG_DRUG |
233386 | RXNORM |
C0772505 | UMLSCUI |
CHEBI:76128 | CHEBI |
9KL | PDB_CHEM_ID |
CHEMBL75435 | ChEMBL_ID |
667550 | PUBCHEM_CID |
DB09214 | DRUGBANK_ID |
7120 | INN_ID |
C118296 | MESH_SUPPLEMENTAL_RECORD_UI |
007781 | NDDF |
007782 | NDDF |
329961001 | SNOMEDCT_US |
396018005 | SNOMEDCT_US |
427618005 | SNOMEDCT_US |
None