dexketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 833 22161-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexketoprofen trometamol
  • dexketoprofen
  • (S)-Ketoprofen
  • (+)-Ketoprofen
a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen
  • Molecular weight: 254.29
  • Formula: C16H14O3
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.08
  • ROTB: 4

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tubulointerstitial nephritis 83.99 37.85 27 1422 19876 63467697
Hepatic cytolysis 61.30 37.85 20 1429 15387 63472186
Angioedema 60.87 37.85 27 1422 47938 63439635
Drug interaction 57.64 37.85 45 1404 229086 63258487
Hyperbilirubinaemia 54.54 37.85 17 1432 11297 63476276
Lichen planus 47.71 37.85 11 1438 2327 63485246
Jaundice 38.79 37.85 17 1432 29234 63458339
Anaphylactic reaction 38.61 37.85 22 1427 66078 63421495

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperaesthesia 74.83 33.22 19 1026 4611 34951275
Quality of life decreased 62.58 33.22 16 1029 3985 34951901
Polyneuropathy in malignant disease 62.25 33.22 10 1035 235 34955651
Allodynia 44.10 33.22 9 1036 822 34955064
Acute kidney injury 43.30 33.22 49 996 304939 34650947
Hyperkalaemia 34.62 33.22 23 1022 69366 34886520

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 70.51 28.65 85 2495 519319 79222489
Hepatic cytolysis 66.50 28.65 27 2553 27124 79714684
Hyperbilirubinaemia 65.65 28.65 26 2554 24492 79717316
Tubulointerstitial nephritis 63.87 28.65 29 2551 38206 79703602
Angioedema 60.60 28.65 35 2545 76000 79665808
Polyneuropathy in malignant disease 59.81 28.65 10 2570 278 79741530
Hypocoagulable state 55.05 28.65 13 2567 2146 79739662
Hyperaesthesia 55.04 28.65 19 2561 12203 79729605
Quality of life decreased 50.04 28.65 17 2563 10403 79731405
Drug interaction 49.85 28.65 64 2516 415119 79326689
Hepatitis cholestatic 38.15 28.65 15 2565 13837 79727971
Allodynia 37.23 28.65 9 2571 1639 79740169
Lichen planus 32.52 28.65 9 2571 2782 79739026
Bradyphrenia 30.99 28.65 12 2568 10628 79731180
Hyperkalaemia 30.46 28.65 27 2553 114371 79627437
Fracture displacement 28.71 28.65 7 2573 1321 79740487

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AE17 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M02AA27 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC N02AJ14 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:50629 COX-2 inhibitor
CHEBI has role CHEBI:50630 COX-1 inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.57 CHEMBL KEGG DRUG
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 8.72 CHEMBL KEGG DRUG

External reference:

IDSource
6KD9E78X68 UNII
D07269 KEGG_DRUG
233386 RXNORM
C0772505 UMLSCUI
CHEBI:76128 CHEBI
9KL PDB_CHEM_ID
CHEMBL75435 ChEMBL_ID
667550 PUBCHEM_CID
DB09214 DRUGBANK_ID
7120 INN_ID
C118296 MESH_SUPPLEMENTAL_RECORD_UI
007781 NDDF
007782 NDDF
329961001 SNOMEDCT_US
396018005 SNOMEDCT_US
427618005 SNOMEDCT_US

Pharmaceutical products:

None