Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory agents, ibuprofen derivatives | 833 | 22161-81-5 |
Dose | Unit | Route |
---|---|---|
75 | mg | O |
75 | mg | P |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug interaction | 65.05 | 34.86 | 47 | 1077 | 203047 | 46481891 |
Lichen planus | 49.80 | 34.86 | 11 | 1113 | 1822 | 46683116 |
Angioedema | 48.34 | 34.86 | 22 | 1102 | 39320 | 46645618 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyperaesthesia | 59.89 | 32.92 | 15 | 852 | 3558 | 29948053 |
Quality of life decreased | 46.48 | 32.92 | 12 | 855 | 3205 | 29948406 |
Acute kidney injury | 38.37 | 32.92 | 43 | 824 | 273799 | 29677812 |
Bronchial aspiration procedure | 33.79 | 32.92 | 5 | 862 | 69 | 29951542 |
Source | Code | Description |
---|---|---|
ATC | M01AE17 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
ATC | M02AA27 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
ATC | N02AJ14 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drugs |
CHEBI has role | CHEBI:50629 | cyclooxygenase-2 inhibitor |
CHEBI has role | CHEBI:50630 | cyclooxygenase-1 inhibitor |
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.28 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 8.72 | CHEMBL | KEGG DRUG | |||
Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 7.57 | CHEMBL | KEGG DRUG |
ID | Source |
---|---|
D07269 | KEGG_DRUG |
C0772505 | UMLSCUI |
CHEBI:76128 | CHEBI |
9KL | PDB_CHEM_ID |
667550 | PUBCHEM_CID |
CHEMBL75435 | ChEMBL_ID |
DB09214 | DRUGBANK_ID |
C118296 | MESH_SUPPLEMENTAL_RECORD_UI |
7120 | INN_ID |
6KD9E78X68 | UNII |
233386 | RXNORM |
007781 | NDDF |
007782 | NDDF |
329961001 | SNOMEDCT_US |
396018005 | SNOMEDCT_US |
427618005 | SNOMEDCT_US |
None