dexketoprofen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 833 22161-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexketoprofen trometamol
  • dexketoprofen
  • (S)-Ketoprofen
  • (+)-Ketoprofen
a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen
  • Molecular weight: 254.29
  • Formula: C16H14O3
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.08
  • ROTB: 4

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 65.05 34.86 47 1077 203047 46481891
Lichen planus 49.80 34.86 11 1113 1822 46683116
Angioedema 48.34 34.86 22 1102 39320 46645618

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperaesthesia 59.89 32.92 15 852 3558 29948053
Quality of life decreased 46.48 32.92 12 855 3205 29948406
Acute kidney injury 38.37 32.92 43 824 273799 29677812
Bronchial aspiration procedure 33.79 32.92 5 862 69 29951542

Pharmacologic Action:

SourceCodeDescription
ATC M01AE17 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M02AA27 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC N02AJ14 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drugs
CHEBI has role CHEBI:50629 cyclooxygenase-2 inhibitor
CHEBI has role CHEBI:50630 cyclooxygenase-1 inhibitor

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 8.72 CHEMBL KEGG DRUG
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.57 CHEMBL KEGG DRUG

External reference:

IDSource
D07269 KEGG_DRUG
C0772505 UMLSCUI
CHEBI:76128 CHEBI
9KL PDB_CHEM_ID
667550 PUBCHEM_CID
CHEMBL75435 ChEMBL_ID
DB09214 DRUGBANK_ID
C118296 MESH_SUPPLEMENTAL_RECORD_UI
7120 INN_ID
6KD9E78X68 UNII
233386 RXNORM
007781 NDDF
007782 NDDF
329961001 SNOMEDCT_US
396018005 SNOMEDCT_US
427618005 SNOMEDCT_US

Pharmaceutical products:

None