dexketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	833	22161-81-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dexketoprofen trometamol dexketoprofen (S)-Ketoprofen (+)-Ketoprofen	a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen Molecular weight: 254.29 Formula: C16H14O3 CLOGP: 2.76 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 54.37 ALOGS: -4.08 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexketoprofen trometamol
dexketoprofen
(S)-Ketoprofen
(+)-Ketoprofen

a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen

Molecular weight: 254.29
Formula: C16H14O3
CLOGP: 2.76
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 54.37
ALOGS: -4.08
ROTB: 4

Drug dosage:

Dose	Unit	Route
75	mg	O
75	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tubulointerstitial nephritis	83.99	37.85	27	1422	19876	63467697
Hepatic cytolysis	61.30	37.85	20	1429	15387	63472186
Angioedema	60.87	37.85	27	1422	47938	63439635
Drug interaction	57.64	37.85	45	1404	229086	63258487
Hyperbilirubinaemia	54.54	37.85	17	1432	11297	63476276
Lichen planus	47.71	37.85	11	1438	2327	63485246
Jaundice	38.79	37.85	17	1432	29234	63458339
Anaphylactic reaction	38.61	37.85	22	1427	66078	63421495

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperaesthesia	74.83	33.22	19	1026	4611	34951275
Quality of life decreased	62.58	33.22	16	1029	3985	34951901
Polyneuropathy in malignant disease	62.25	33.22	10	1035	235	34955651
Allodynia	44.10	33.22	9	1036	822	34955064
Acute kidney injury	43.30	33.22	49	996	304939	34650947
Hyperkalaemia	34.62	33.22	23	1022	69366	34886520

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	70.51	28.65	85	2495	519319	79222489
Hepatic cytolysis	66.50	28.65	27	2553	27124	79714684
Hyperbilirubinaemia	65.65	28.65	26	2554	24492	79717316
Tubulointerstitial nephritis	63.87	28.65	29	2551	38206	79703602
Angioedema	60.60	28.65	35	2545	76000	79665808
Polyneuropathy in malignant disease	59.81	28.65	10	2570	278	79741530
Hypocoagulable state	55.05	28.65	13	2567	2146	79739662
Hyperaesthesia	55.04	28.65	19	2561	12203	79729605
Quality of life decreased	50.04	28.65	17	2563	10403	79731405
Drug interaction	49.85	28.65	64	2516	415119	79326689

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	M01AE17	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives
ATC	M02AA27	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
ATC	N02AJ14	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:50629	COX-2 inhibitor
CHEBI has role	CHEBI:50630	COX-1 inhibitor
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.28	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	7.57		CHEMBL	KEGG DRUG
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN	INHIBITOR	IC50	8.72		CHEMBL	KEGG DRUG

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External reference:

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ID	Source
9KL	PDB_CHEM_ID
007781	NDDF
007782	NDDF
233386	RXNORM
329961001	SNOMEDCT_US
396018005	SNOMEDCT_US
427618005	SNOMEDCT_US
667550	PUBCHEM_CID
6KD9E78X68	UNII
7120	INN_ID

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Pharmaceutical products:

None