dexketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 833 22161-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexketoprofen trometamol
  • dexketoprofen
  • (S)-Ketoprofen
  • (+)-Ketoprofen
a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen
  • Molecular weight: 254.29
  • Formula: C16H14O3
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.08
  • ROTB: 4

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tubulointerstitial nephritis 67.03 35.07 22 1311 16643 56274091
Hyperbilirubinaemia 55.61 35.07 17 1316 10218 56280516
Drug interaction 55.33 35.07 43 1290 209712 56081022
Angioedema 53.90 35.07 24 1309 41429 56249305
Lichen planus 48.27 35.07 11 1322 2131 56288603
Anaphylactic reaction 37.46 35.07 21 1312 58974 56231760
Acute kidney injury 36.39 35.07 36 1297 240727 56050007

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperaesthesia 58.98 34.67 15 867 3936 31692526
Quality of life decreased 46.10 34.67 12 870 3443 31693019
Acute kidney injury 39.00 34.67 43 839 279671 31416791
Hyperkalaemia 37.77 34.67 23 859 64328 31632134

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperbilirubinaemia 67.82 29.09 26 2263 22542 70903613
Acute kidney injury 66.82 29.09 79 2210 474545 70451610
Angioedema 56.76 29.09 32 2257 66578 70859577
Tubulointerstitial nephritis 51.89 29.09 24 2265 33052 70893103
Drug interaction 51.09 29.09 62 2227 381379 70544776
Hepatic cytolysis 43.34 29.09 18 2271 19174 70906981
Hyperaesthesia 41.64 29.09 15 2274 10927 70915228
Hepatitis cholestatic 39.51 29.09 15 2274 12635 70913520
Quality of life decreased 37.48 29.09 13 2276 8482 70917673
Lichen planus 33.40 29.09 9 2280 2526 70923629
Hyperkalaemia 32.19 29.09 27 2262 106564 70819591
Bradyphrenia 31.81 29.09 12 2277 9934 70916221
Polyneuropathy in malignant disease 29.39 29.09 5 2284 155 70926000
Fracture displacement 29.33 29.09 7 2282 1211 70924944

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AE17 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M02AA27 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC N02AJ14 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:50629 COX-2 inhibitor
CHEBI has role CHEBI:50630 COX-1 inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.57 CHEMBL KEGG DRUG
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 8.72 CHEMBL KEGG DRUG

External reference:

IDSource
6KD9E78X68 UNII
D07269 KEGG_DRUG
233386 RXNORM
C0772505 UMLSCUI
CHEBI:76128 CHEBI
9KL PDB_CHEM_ID
CHEMBL75435 ChEMBL_ID
667550 PUBCHEM_CID
DB09214 DRUGBANK_ID
7120 INN_ID
C118296 MESH_SUPPLEMENTAL_RECORD_UI
007781 NDDF
007782 NDDF
329961001 SNOMEDCT_US
396018005 SNOMEDCT_US
427618005 SNOMEDCT_US

Pharmaceutical products:

None