dexketoprofen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 833 22161-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexketoprofen trometamol
  • dexketoprofen
  • (S)-Ketoprofen
  • (+)-Ketoprofen
a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen
  • Molecular weight: 254.29
  • Formula: C16H14O3
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.08
  • ROTB: 4

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AE17 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M02AA27 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC N02AJ14 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 8.72 CHEMBL KEGG DRUG
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.57 CHEMBL KEGG DRUG

External reference:

IDSource
C0772505 UMLSCUI
D07269 KEGG_DRUG
6KD9E78X68 UNII
7120 INN_ID
329961001 SNOMEDCT_US
396018005 SNOMEDCT_US
237162 RXNORM
007781 NDDF
CHEBI:76128 CHEBI
CHEMBL75435 ChEMBL_ID
DB09214 DRUGBANK_ID
667550 PUBCHEM_CID
C118296 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None