dexketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	833	22161-81-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexketoprofen trometamol
dexketoprofen
(S)-Ketoprofen
(+)-Ketoprofen

a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen

Molecular weight: 254.29
Formula: C16H14O3
CLOGP: 2.76
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 54.37
ALOGS: -4.08
ROTB: 4

Drug dosage:

Dose	Unit	Route
75	mg	O
75	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tubulointerstitial nephritis	67.03	35.07	22	1311	16643	56274091
Hyperbilirubinaemia	55.61	35.07	17	1316	10218	56280516
Drug interaction	55.33	35.07	43	1290	209712	56081022
Angioedema	53.90	35.07	24	1309	41429	56249305
Lichen planus	48.27	35.07	11	1322	2131	56288603
Anaphylactic reaction	37.46	35.07	21	1312	58974	56231760
Acute kidney injury	36.39	35.07	36	1297	240727	56050007

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperaesthesia	58.98	34.67	15	867	3936	31692526
Quality of life decreased	46.10	34.67	12	870	3443	31693019
Acute kidney injury	39.00	34.67	43	839	279671	31416791
Hyperkalaemia	37.77	34.67	23	859	64328	31632134

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperbilirubinaemia	67.82	29.09	26	2263	22542	70903613
Acute kidney injury	66.82	29.09	79	2210	474545	70451610
Angioedema	56.76	29.09	32	2257	66578	70859577
Tubulointerstitial nephritis	51.89	29.09	24	2265	33052	70893103
Drug interaction	51.09	29.09	62	2227	381379	70544776
Hepatic cytolysis	43.34	29.09	18	2271	19174	70906981
Hyperaesthesia	41.64	29.09	15	2274	10927	70915228
Hepatitis cholestatic	39.51	29.09	15	2274	12635	70913520
Quality of life decreased	37.48	29.09	13	2276	8482	70917673
Lichen planus	33.40	29.09	9	2280	2526	70923629
Hyperkalaemia	32.19	29.09	27	2262	106564	70819591
Bradyphrenia	31.81	29.09	12	2277	9934	70916221
Polyneuropathy in malignant disease	29.39	29.09	5	2284	155	70926000
Fracture displacement	29.33	29.09	7	2282	1211	70924944

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M01AE17	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives
ATC	M02AA27	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
ATC	N02AJ14	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:50629	COX-2 inhibitor
CHEBI has role	CHEBI:50630	COX-1 inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.28	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	7.57		CHEMBL	KEGG DRUG
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN	INHIBITOR	IC50	8.72		CHEMBL	KEGG DRUG

External reference:

ID	Source
6KD9E78X68	UNII
D07269	KEGG_DRUG
233386	RXNORM
C0772505	UMLSCUI
CHEBI:76128	CHEBI
9KL	PDB_CHEM_ID
CHEMBL75435	ChEMBL_ID
667550	PUBCHEM_CID
DB09214	DRUGBANK_ID
7120	INN_ID
C118296	MESH_SUPPLEMENTAL_RECORD_UI
007781	NDDF
007782	NDDF
329961001	SNOMEDCT_US
396018005	SNOMEDCT_US
427618005	SNOMEDCT_US

Pharmaceutical products:

None