Stem definition | Drug id | CAS RN |
---|---|---|
antihyperlipidaemic substances, HMG CoA reductase inhibitors | 2406 | 287714-41-4 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.19 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Hosey CM, Chan R, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 30 % | Hosey CM, Chan R, Benet LZ |
BA (Bioavailability) | 20 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.70 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 11 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 12, 2003 | FDA | IPR | |
Jan. 19, 2005 | PMDA | AstraZeneca K.K. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rhabdomyolysis | 1001.28 | 9.65 | 858 | 144684 | 38169 | 50421413 |
Myalgia | 774.04 | 9.65 | 1327 | 144215 | 122992 | 50336590 |
Blood creatine phosphokinase increased | 376.88 | 9.65 | 421 | 145121 | 25946 | 50433636 |
Maternal exposure during pregnancy | 359.50 | 9.65 | 26 | 145516 | 159752 | 50299830 |
Sedation complication | 310.49 | 9.65 | 233 | 145309 | 8533 | 50451049 |
Creatinine renal clearance decreased | 289.86 | 9.65 | 254 | 145288 | 11627 | 50447955 |
Pemphigus | 287.09 | 9.65 | 14 | 145528 | 120152 | 50339430 |
Systemic lupus erythematosus | 279.41 | 9.65 | 37 | 145505 | 140585 | 50318997 |
Orthostatic hypotension | 269.11 | 9.65 | 376 | 145166 | 29105 | 50430477 |
Cognitive disorder | 214.69 | 9.65 | 424 | 145118 | 43699 | 50415883 |
Glossodynia | 207.98 | 9.65 | 40 | 145502 | 115529 | 50344053 |
Exposure during pregnancy | 207.25 | 9.65 | 47 | 145495 | 120968 | 50338614 |
Treatment failure | 206.68 | 9.65 | 69 | 145473 | 137568 | 50322014 |
Low density lipoprotein increased | 206.49 | 9.65 | 153 | 145389 | 5493 | 50454089 |
Blood calcium decreased | 197.83 | 9.65 | 270 | 145272 | 20436 | 50439146 |
Myopathy | 194.61 | 9.65 | 181 | 145361 | 8958 | 50450624 |
Drug ineffective | 192.64 | 9.65 | 1476 | 144066 | 817857 | 49641725 |
Contraindicated product administered | 190.70 | 9.65 | 95 | 145447 | 148863 | 50310719 |
Hand deformity | 183.89 | 9.65 | 33 | 145509 | 100166 | 50359416 |
Anti-cyclic citrullinated peptide antibody positive | 183.44 | 9.65 | 4 | 145538 | 70583 | 50388999 |
Wound | 171.59 | 9.65 | 46 | 145496 | 105748 | 50353834 |
Synovitis | 166.22 | 9.65 | 74 | 145468 | 123791 | 50335791 |
Sedation | 162.18 | 9.65 | 305 | 145237 | 30305 | 50429277 |
Balance disorder | 160.35 | 9.65 | 507 | 145035 | 70083 | 50389499 |
Acute kidney injury | 151.35 | 9.65 | 1148 | 144394 | 226910 | 50232672 |
Angina pectoris | 137.57 | 9.65 | 260 | 145282 | 25928 | 50433654 |
Pericarditis | 135.82 | 9.65 | 30 | 145512 | 78659 | 50380923 |
Muscle spasms | 129.53 | 9.65 | 707 | 144835 | 124846 | 50334736 |
Completed suicide | 127.31 | 9.65 | 115 | 145427 | 131774 | 50327808 |
High density lipoprotein decreased | 126.56 | 9.65 | 72 | 145470 | 1628 | 50457954 |
Duodenal ulcer perforation | 106.72 | 9.65 | 6 | 145536 | 45605 | 50413977 |
Blood triglycerides increased | 105.77 | 9.65 | 146 | 145396 | 11166 | 50448416 |
Death | 105.62 | 9.65 | 529 | 145013 | 324850 | 50134732 |
Arthropathy | 105.06 | 9.65 | 183 | 145359 | 157723 | 50301859 |
Helicobacter infection | 98.84 | 9.65 | 13 | 145529 | 49689 | 50409893 |
Off label use | 96.68 | 9.65 | 886 | 144656 | 473540 | 49986042 |
Immune-mediated myositis | 96.42 | 9.65 | 51 | 145491 | 994 | 50458588 |
Constipation | 91.93 | 9.65 | 876 | 144666 | 184832 | 50274750 |
Product use issue | 88.27 | 9.65 | 186 | 145356 | 149289 | 50310293 |
Psoriasis | 86.11 | 9.65 | 410 | 145132 | 68590 | 50390992 |
Therapeutic product effect decreased | 85.73 | 9.65 | 163 | 145379 | 135887 | 50323695 |
Fall | 84.02 | 9.65 | 1391 | 144151 | 333541 | 50126041 |
Blood glucose increased | 82.71 | 9.65 | 415 | 145127 | 70909 | 50388673 |
Infection | 82.01 | 9.65 | 241 | 145301 | 172713 | 50286869 |
Folliculitis | 81.09 | 9.65 | 9 | 145533 | 39216 | 50420366 |
Blood pressure increased | 79.81 | 9.65 | 655 | 144887 | 132477 | 50327105 |
Dyslipidaemia | 77.73 | 9.65 | 91 | 145451 | 5897 | 50453685 |
Euglycaemic diabetic ketoacidosis | 76.35 | 9.65 | 64 | 145478 | 2755 | 50456827 |
Liver disorder | 74.33 | 9.65 | 256 | 145286 | 36966 | 50422616 |
Drug abuse | 72.36 | 9.65 | 41 | 145501 | 59805 | 50399777 |
Drug intolerance | 71.70 | 9.65 | 355 | 145187 | 218749 | 50240833 |
Depressed level of consciousness | 70.95 | 9.65 | 317 | 145225 | 51636 | 50407946 |
Impaired healing | 70.78 | 9.65 | 58 | 145484 | 69728 | 50389854 |
Renal failure | 70.69 | 9.65 | 537 | 145005 | 106096 | 50353486 |
Hypotension | 69.31 | 9.65 | 1005 | 144537 | 234464 | 50225118 |
Infusion related reaction | 68.16 | 9.65 | 254 | 145288 | 169303 | 50290279 |
Asthenia | 66.83 | 9.65 | 1288 | 144254 | 317754 | 50141828 |
Blood pressure systolic increased | 66.64 | 9.65 | 239 | 145303 | 35210 | 50424372 |
Pregnancy | 65.92 | 9.65 | 5 | 145537 | 29572 | 50430010 |
Diabetic ketoacidosis | 65.33 | 9.65 | 153 | 145389 | 17719 | 50441863 |
Abortion spontaneous | 64.31 | 9.65 | 20 | 145522 | 41752 | 50417830 |
Sleep disorder due to general medical condition, insomnia type | 63.06 | 9.65 | 8 | 145534 | 31439 | 50428143 |
Discomfort | 63.01 | 9.65 | 136 | 145406 | 108244 | 50351338 |
Muscle injury | 62.33 | 9.65 | 15 | 145527 | 37096 | 50422486 |
Swelling | 60.36 | 9.65 | 335 | 145207 | 200537 | 50259045 |
Device expulsion | 58.61 | 9.65 | 7 | 145535 | 28815 | 50430767 |
Muscular weakness | 55.06 | 9.65 | 464 | 145078 | 94549 | 50365033 |
Drug interaction | 54.04 | 9.65 | 840 | 144702 | 198781 | 50260801 |
Alopecia | 54.02 | 9.65 | 448 | 145094 | 244599 | 50214983 |
General physical health deterioration | 53.63 | 9.65 | 219 | 145323 | 142215 | 50317367 |
Neutropenia | 51.73 | 9.65 | 234 | 145308 | 147731 | 50311851 |
Blister | 51.48 | 9.65 | 105 | 145437 | 85313 | 50374269 |
Hypoglycaemia | 51.39 | 9.65 | 296 | 145246 | 53285 | 50406297 |
Disease progression | 51.12 | 9.65 | 126 | 145416 | 95740 | 50363842 |
Intentional overdose | 50.75 | 9.65 | 63 | 145479 | 62441 | 50397141 |
Dermatitis allergic | 49.92 | 9.65 | 112 | 145430 | 12608 | 50446974 |
Low density lipoprotein decreased | 49.44 | 9.65 | 20 | 145522 | 203 | 50459379 |
Irritable bowel syndrome | 49.42 | 9.65 | 45 | 145497 | 51396 | 50408186 |
Abdominal discomfort | 48.58 | 9.65 | 429 | 145113 | 231212 | 50228370 |
Pain in extremity | 48.35 | 9.65 | 1075 | 144467 | 271790 | 50187792 |
Foetal exposure during pregnancy | 48.07 | 9.65 | 10 | 145532 | 27349 | 50432233 |
Hip arthroplasty | 47.88 | 9.65 | 14 | 145528 | 30415 | 50429167 |
Premature delivery | 47.50 | 9.65 | 6 | 145536 | 23657 | 50435925 |
Asthma | 46.93 | 9.65 | 427 | 145115 | 88910 | 50370672 |
Arterial occlusive disease | 46.37 | 9.65 | 63 | 145479 | 4745 | 50454837 |
Foetal acidosis | 45.80 | 9.65 | 11 | 145531 | 11 | 50459571 |
Hyper IgE syndrome | 45.27 | 9.65 | 23 | 145519 | 411 | 50459171 |
Pancreatitis | 45.25 | 9.65 | 242 | 145300 | 42372 | 50417210 |
Chronic kidney disease | 45.09 | 9.65 | 230 | 145312 | 39541 | 50420041 |
Restrictive pulmonary disease | 44.19 | 9.65 | 35 | 145507 | 1389 | 50458193 |
Myocardial infarction | 44.00 | 9.65 | 420 | 145122 | 88607 | 50370975 |
Lactic acidosis | 43.65 | 9.65 | 201 | 145341 | 33154 | 50426428 |
Reversible airways obstruction | 42.69 | 9.65 | 30 | 145512 | 990 | 50458592 |
Hepatitis | 42.24 | 9.65 | 191 | 145351 | 31262 | 50428320 |
Rash | 41.88 | 9.65 | 949 | 144593 | 436522 | 50023060 |
Febrile neutropenia | 41.42 | 9.65 | 143 | 145399 | 97524 | 50362058 |
Angina unstable | 40.83 | 9.65 | 71 | 145471 | 6635 | 50452947 |
Pancytopenia | 39.85 | 9.65 | 117 | 145425 | 83913 | 50375669 |
Obstructive airways disorder | 39.79 | 9.65 | 117 | 145425 | 15535 | 50444047 |
Seizure | 39.08 | 9.65 | 190 | 145352 | 117684 | 50341898 |
Mobility decreased | 38.92 | 9.65 | 376 | 145166 | 79572 | 50380010 |
Product use in unapproved indication | 38.79 | 9.65 | 186 | 145356 | 115633 | 50343949 |
Condition aggravated | 38.72 | 9.65 | 611 | 144931 | 296447 | 50163135 |
Drug-induced liver injury | 38.02 | 9.65 | 171 | 145371 | 27924 | 50431658 |
Full blood count abnormal | 37.59 | 9.65 | 150 | 145392 | 23238 | 50436344 |
Ulnar tunnel syndrome | 37.48 | 9.65 | 9 | 145533 | 9 | 50459573 |
Vital capacity decreased | 37.43 | 9.65 | 27 | 145515 | 929 | 50458653 |
Glycosylated haemoglobin increased | 36.82 | 9.65 | 89 | 145453 | 10517 | 50449065 |
Diabetes mellitus inadequate control | 36.07 | 9.65 | 101 | 145441 | 13044 | 50446538 |
Chromaturia | 35.14 | 9.65 | 107 | 145435 | 14483 | 50445099 |
Coma | 35.05 | 9.65 | 69 | 145473 | 56810 | 50402772 |
Burning sensation | 34.79 | 9.65 | 237 | 145305 | 45209 | 50414373 |
Ischaemic stroke | 34.77 | 9.65 | 113 | 145429 | 15835 | 50443747 |
Rheumatic fever | 34.54 | 9.65 | 4 | 145538 | 16863 | 50442719 |
Lipids increased | 34.23 | 9.65 | 27 | 145515 | 1065 | 50458517 |
Diabetes mellitus | 34.20 | 9.65 | 250 | 145292 | 48783 | 50410799 |
Stomatitis | 33.79 | 9.65 | 163 | 145379 | 101181 | 50358401 |
Necrotising myositis | 33.52 | 9.65 | 18 | 145524 | 362 | 50459220 |
Leukopenia | 33.51 | 9.65 | 92 | 145450 | 67436 | 50392146 |
Cystitis | 32.69 | 9.65 | 230 | 145312 | 44334 | 50415248 |
Muscle discomfort | 32.49 | 9.65 | 12 | 145530 | 93 | 50459489 |
Blood creatinine increased | 32.20 | 9.65 | 348 | 145194 | 75812 | 50383770 |
Androgenetic alopecia | 31.54 | 9.65 | 13 | 145529 | 139 | 50459443 |
Nephritic syndrome | 31.54 | 9.65 | 14 | 145528 | 182 | 50459400 |
Bone erosion | 31.29 | 9.65 | 89 | 145453 | 11598 | 50447984 |
Coronary artery disease | 31.01 | 9.65 | 168 | 145374 | 29558 | 50430024 |
Product substitution issue | 31.00 | 9.65 | 100 | 145442 | 13957 | 50445625 |
Bronchiectasis | 30.19 | 9.65 | 81 | 145461 | 10202 | 50449380 |
Joint swelling | 30.13 | 9.65 | 510 | 145032 | 244776 | 50214806 |
Sinus congestion | 29.57 | 9.65 | 98 | 145444 | 13873 | 50445709 |
Weight decreased | 29.46 | 9.65 | 839 | 144703 | 220406 | 50239176 |
Hepatocellular injury | 29.37 | 9.65 | 150 | 145392 | 25797 | 50433785 |
Type 2 diabetes mellitus | 29.19 | 9.65 | 184 | 145358 | 34191 | 50425391 |
Intentional self-injury | 29.15 | 9.65 | 15 | 145527 | 23097 | 50436485 |
Blood test abnormal | 29.14 | 9.65 | 85 | 145457 | 11234 | 50448348 |
Caesarean section | 29 | 9.65 | 5 | 145537 | 15634 | 50443948 |
Confabulation | 28.89 | 9.65 | 15 | 145527 | 281 | 50459301 |
Bronchial secretion retention | 28.48 | 9.65 | 28 | 145514 | 1485 | 50458097 |
Skin haemorrhage | 28.37 | 9.65 | 62 | 145480 | 6856 | 50452726 |
Sputum culture positive | 28.18 | 9.65 | 27 | 145515 | 1387 | 50458195 |
Injection site reaction | 28.06 | 9.65 | 64 | 145478 | 49968 | 50409614 |
Alanine aminotransferase increased | 27.88 | 9.65 | 382 | 145160 | 87977 | 50371605 |
Hyperkeratosis | 27.69 | 9.65 | 51 | 145491 | 4984 | 50454598 |
Pertussis | 27.25 | 9.65 | 19 | 145523 | 619 | 50458963 |
Dizziness | 27.21 | 9.65 | 1237 | 144305 | 345132 | 50114450 |
Malignant mediastinal neoplasm | 26.94 | 9.65 | 18 | 145524 | 546 | 50459036 |
Hyperglycaemia | 26.77 | 9.65 | 188 | 145354 | 36217 | 50423365 |
Hyperlactacidaemia | 26.75 | 9.65 | 34 | 145508 | 2399 | 50457183 |
Crush syndrome | 26.66 | 9.65 | 11 | 145531 | 118 | 50459464 |
Coronary artery occlusion | 26.08 | 9.65 | 63 | 145479 | 7440 | 50452142 |
Pulmonary function test abnormal | 26.06 | 9.65 | 25 | 145517 | 1286 | 50458296 |
Cough | 25.80 | 9.65 | 891 | 144651 | 240373 | 50219209 |
Sepsis | 25.75 | 9.65 | 251 | 145291 | 132674 | 50326908 |
Amblyopia | 25.65 | 9.65 | 13 | 145529 | 231 | 50459351 |
Creutzfeldt-Jakob disease | 25.42 | 9.65 | 11 | 145531 | 134 | 50459448 |
Generalised tonic-clonic seizure | 25.29 | 9.65 | 23 | 145519 | 26287 | 50433295 |
Cytomegalovirus infection | 25.24 | 9.65 | 10 | 145532 | 17952 | 50441630 |
Transcription medication error | 25.20 | 9.65 | 12 | 145530 | 185 | 50459397 |
Gangrene | 25.15 | 9.65 | 47 | 145495 | 4645 | 50454937 |
Carotid artery thrombosis | 25.03 | 9.65 | 26 | 145516 | 1473 | 50458109 |
Blood creatine phosphokinase | 24.98 | 9.65 | 6 | 145536 | 6 | 50459576 |
Goitre | 24.51 | 9.65 | 50 | 145492 | 5270 | 50454312 |
Intentional product use issue | 24.33 | 9.65 | 126 | 145416 | 76792 | 50382790 |
Device dislocation | 24.31 | 9.65 | 16 | 145526 | 21530 | 50438052 |
Microalbuminuria | 24.05 | 9.65 | 14 | 145528 | 331 | 50459251 |
Thrombocytopenia | 23.93 | 9.65 | 243 | 145299 | 127430 | 50332152 |
Polymyositis | 23.90 | 9.65 | 26 | 145516 | 1554 | 50458028 |
Myositis | 23.88 | 9.65 | 63 | 145479 | 7857 | 50451725 |
Neurologic neglect syndrome | 23.83 | 9.65 | 25 | 145517 | 1433 | 50458149 |
Hypersensitivity | 23.68 | 9.65 | 456 | 145086 | 214705 | 50244877 |
Respiratory arrest | 23.58 | 9.65 | 31 | 145511 | 29978 | 50429604 |
Lung diffusion test decreased | 23.39 | 9.65 | 17 | 145525 | 592 | 50458990 |
Degenerative aortic valve disease | 23.30 | 9.65 | 9 | 145533 | 80 | 50459502 |
Cataract | 23.28 | 9.65 | 223 | 145319 | 47077 | 50412505 |
Glomerular filtration rate decreased | 23.13 | 9.65 | 80 | 145462 | 11572 | 50448010 |
Acute myocardial infarction | 22.60 | 9.65 | 153 | 145389 | 29120 | 50430462 |
Muscle disorder | 22.60 | 9.65 | 43 | 145499 | 4307 | 50455275 |
Aspartate aminotransferase increased | 22.52 | 9.65 | 332 | 145210 | 77666 | 50381916 |
Pyrexia | 22.50 | 9.65 | 880 | 144662 | 379323 | 50080259 |
Cerebral infarction | 22.46 | 9.65 | 122 | 145420 | 21482 | 50438100 |
Hepatic function abnormal | 22.43 | 9.65 | 166 | 145376 | 32515 | 50427067 |
Blood pressure inadequately controlled | 22.39 | 9.65 | 43 | 145499 | 4337 | 50455245 |
Albuminuria | 22.09 | 9.65 | 11 | 145531 | 188 | 50459394 |
Adverse drug reaction | 21.98 | 9.65 | 83 | 145459 | 55139 | 50404443 |
Acute coronary syndrome | 21.88 | 9.65 | 68 | 145474 | 9306 | 50450276 |
Hypereosinophilic syndrome | 21.67 | 9.65 | 12 | 145530 | 257 | 50459325 |
Drug resistance | 21.56 | 9.65 | 14 | 145528 | 18975 | 50440607 |
Lipids abnormal | 21.47 | 9.65 | 12 | 145530 | 262 | 50459320 |
Anuria | 21.29 | 9.65 | 76 | 145466 | 11168 | 50448414 |
Listless | 21.08 | 9.65 | 30 | 145512 | 2360 | 50457222 |
Pancreatic neuroendocrine tumour | 20.91 | 9.65 | 12 | 145530 | 276 | 50459306 |
Blood calcium increased | 20.87 | 9.65 | 59 | 145483 | 7660 | 50451922 |
Infusion site streaking | 20.80 | 9.65 | 14 | 145528 | 430 | 50459152 |
Blood cholesterol abnormal | 20.79 | 9.65 | 29 | 145513 | 2239 | 50457343 |
Malignant neoplasm progression | 20.76 | 9.65 | 113 | 145429 | 68011 | 50391571 |
Chest discomfort | 20.59 | 9.65 | 378 | 145164 | 92344 | 50367238 |
Blood cholesterol increased | 20.50 | 9.65 | 246 | 145296 | 54969 | 50404613 |
Red blood cell sedimentation rate abnormal | 20.29 | 9.65 | 97 | 145445 | 16246 | 50443336 |
Cardio-respiratory arrest | 20.18 | 9.65 | 83 | 145459 | 53809 | 50405773 |
Tubulointerstitial nephritis | 20.14 | 9.65 | 92 | 145450 | 15119 | 50444463 |
Blood immunoglobulin E increased | 19.91 | 9.65 | 29 | 145513 | 2330 | 50457252 |
Toxicity to various agents | 19.69 | 9.65 | 463 | 145079 | 212036 | 50247546 |
Procollagen type I C-terminal propeptide increased | 19.54 | 9.65 | 6 | 145536 | 24 | 50459558 |
Respiratory failure | 19.46 | 9.65 | 168 | 145374 | 91013 | 50368569 |
Metastases to bone | 19.46 | 9.65 | 14 | 145528 | 17981 | 50441601 |
Myopathy toxic | 19.41 | 9.65 | 13 | 145529 | 396 | 50459186 |
Serum procollagen type I N-terminal propeptide increased | 19.34 | 9.65 | 6 | 145536 | 25 | 50459557 |
Interstitial lung disease | 19.34 | 9.65 | 236 | 145306 | 52940 | 50406642 |
Amylase increased | 19.31 | 9.65 | 46 | 145496 | 5384 | 50454198 |
Poisoning | 19.04 | 9.65 | 6 | 145536 | 12423 | 50447159 |
Blood glucose abnormal | 19.03 | 9.65 | 52 | 145490 | 6620 | 50452962 |
Malaise | 18.63 | 9.65 | 1160 | 144382 | 334372 | 50125210 |
Gastrointestinal disorder | 18.44 | 9.65 | 178 | 145364 | 94278 | 50365304 |
Bone marrow failure | 18.36 | 9.65 | 32 | 145510 | 27592 | 50431990 |
Haemorrhage subcutaneous | 18.31 | 9.65 | 30 | 145512 | 2671 | 50456911 |
Coronary artery stenosis | 18.23 | 9.65 | 39 | 145503 | 4250 | 50455332 |
Infected dermal cyst | 18.18 | 9.65 | 13 | 145529 | 441 | 50459141 |
Urine albumin/creatinine ratio increased | 18.15 | 9.65 | 10 | 145532 | 212 | 50459370 |
Multiple sclerosis relapse | 18.14 | 9.65 | 63 | 145479 | 42901 | 50416681 |
Bursitis infective | 18.13 | 9.65 | 20 | 145522 | 1214 | 50458368 |
Malignant melanoma | 18.02 | 9.65 | 67 | 145475 | 10041 | 50449541 |
Hypercreatininaemia | 17.82 | 9.65 | 12 | 145530 | 369 | 50459213 |
Dry mouth | 17.77 | 9.65 | 243 | 145299 | 55935 | 50403647 |
Peripheral sensorimotor neuropathy | 17.76 | 9.65 | 20 | 145522 | 1242 | 50458340 |
Infrequent bowel movements | 17.69 | 9.65 | 19 | 145523 | 1119 | 50458463 |
Premature baby | 17.66 | 9.65 | 16 | 145526 | 18321 | 50441261 |
Blood pressure abnormal | 17.56 | 9.65 | 78 | 145464 | 12669 | 50446913 |
Vertigo | 17.55 | 9.65 | 227 | 145315 | 51605 | 50407977 |
Palpitations | 17.53 | 9.65 | 375 | 145167 | 94131 | 50365451 |
Pancreatitis acute | 17.52 | 9.65 | 123 | 145419 | 23689 | 50435893 |
Chest pain | 17.36 | 9.65 | 647 | 144895 | 176235 | 50283347 |
Suicide attempt | 17.36 | 9.65 | 83 | 145459 | 51649 | 50407933 |
Hyperphosphataemia | 17.27 | 9.65 | 24 | 145518 | 1847 | 50457735 |
Toxic epidermal necrolysis | 17.20 | 9.65 | 21 | 145521 | 20971 | 50438611 |
Dyspnoea exertional | 17.19 | 9.65 | 224 | 145318 | 51009 | 50408573 |
Head discomfort | 17.17 | 9.65 | 70 | 145472 | 10949 | 50448633 |
Reduced facial expression | 17.09 | 9.65 | 22 | 145520 | 1572 | 50458010 |
Atrial fibrillation | 17.07 | 9.65 | 398 | 145144 | 101347 | 50358235 |
Blood creatine increased | 16.95 | 9.65 | 41 | 145501 | 4846 | 50454736 |
Somnolence | 16.88 | 9.65 | 329 | 145213 | 154656 | 50304926 |
Drug tolerance decreased | 16.83 | 9.65 | 3 | 145539 | 9157 | 50450425 |
Ulcer | 16.77 | 9.65 | 20 | 145522 | 20180 | 50439402 |
Ligament pain | 16.76 | 9.65 | 9 | 145533 | 181 | 50459401 |
Immunodeficiency | 16.74 | 9.65 | 11 | 145531 | 14817 | 50444765 |
Injury | 16.70 | 9.65 | 78 | 145464 | 48847 | 50410735 |
Sinonasal obstruction | 16.54 | 9.65 | 9 | 145533 | 186 | 50459396 |
Sensorimotor disorder | 16.16 | 9.65 | 12 | 145530 | 432 | 50459150 |
Transaminases increased | 16.16 | 9.65 | 136 | 145406 | 27688 | 50431894 |
Eosinophil count increased | 16.14 | 9.65 | 59 | 145483 | 8771 | 50450811 |
Apolipoprotein A-I decreased | 16.09 | 9.65 | 5 | 145537 | 21 | 50459561 |
Ill-defined disorder | 15.92 | 9.65 | 92 | 145450 | 54562 | 50405020 |
Transplant rejection | 15.91 | 9.65 | 4 | 145538 | 9605 | 50449977 |
Unwanted awareness during anaesthesia | 15.83 | 9.65 | 10 | 145532 | 275 | 50459307 |
Lymphopenia | 15.81 | 9.65 | 13 | 145529 | 15608 | 50443974 |
Total lung capacity decreased | 15.73 | 9.65 | 19 | 145523 | 1272 | 50458310 |
Device related infection | 15.70 | 9.65 | 22 | 145520 | 20713 | 50438869 |
Rheumatoid factor positive | 15.58 | 9.65 | 82 | 145460 | 49777 | 50409805 |
Injection site erythema | 15.58 | 9.65 | 139 | 145403 | 74797 | 50384785 |
Intensive care unit acquired weakness | 15.22 | 9.65 | 14 | 145528 | 683 | 50458899 |
Cerebrovascular accident | 15.16 | 9.65 | 368 | 145174 | 94312 | 50365270 |
Panniculitis | 15.16 | 9.65 | 3 | 145539 | 8500 | 50451082 |
Status epilepticus | 15.06 | 9.65 | 10 | 145532 | 13396 | 50446186 |
Oedema peripheral | 15.06 | 9.65 | 576 | 144966 | 157385 | 50302197 |
Mucosal inflammation | 14.91 | 9.65 | 62 | 145480 | 40080 | 50419502 |
Foreign body | 14.88 | 9.65 | 23 | 145519 | 1948 | 50457634 |
Polymyalgia rheumatica | 14.88 | 9.65 | 27 | 145515 | 2609 | 50456973 |
Lichen planus | 14.81 | 9.65 | 23 | 145519 | 1956 | 50457626 |
Drug specific antibody | 14.78 | 9.65 | 22 | 145520 | 1803 | 50457779 |
Obstructive pancreatitis | 14.73 | 9.65 | 9 | 145533 | 233 | 50459349 |
Dystonia | 14.66 | 9.65 | 8 | 145534 | 11918 | 50447664 |
Sinusitis | 14.60 | 9.65 | 376 | 145166 | 170182 | 50289400 |
Hypertension | 14.59 | 9.65 | 745 | 144797 | 210458 | 50249124 |
Coma acidotic | 14.58 | 9.65 | 7 | 145535 | 110 | 50459472 |
Neurotrophic keratopathy | 14.56 | 9.65 | 3 | 145539 | 0 | 50459582 |
Akathisia | 14.47 | 9.65 | 3 | 145539 | 8226 | 50451356 |
Adjustment disorder | 14.47 | 9.65 | 23 | 145519 | 1996 | 50457586 |
Lipoprotein (a) increased | 14.36 | 9.65 | 5 | 145537 | 32 | 50459550 |
Stent placement | 14.31 | 9.65 | 31 | 145511 | 3407 | 50456175 |
Hypocholesterolaemia | 14.30 | 9.65 | 7 | 145535 | 115 | 50459467 |
Hepatic enzyme increased | 14.24 | 9.65 | 294 | 145248 | 137086 | 50322496 |
Neutrophil count decreased | 14.21 | 9.65 | 76 | 145466 | 45950 | 50413632 |
Clitoris abscess | 14.16 | 9.65 | 4 | 145538 | 11 | 50459571 |
Cardiac murmur | 14.11 | 9.65 | 65 | 145477 | 10719 | 50448863 |
Neutropenic sepsis | 14.04 | 9.65 | 12 | 145530 | 14135 | 50445447 |
Eyelid disorder | 14.02 | 9.65 | 18 | 145524 | 1283 | 50458299 |
Hyperkalaemia | 14.00 | 9.65 | 205 | 145337 | 47884 | 50411698 |
Food interaction | 13.98 | 9.65 | 13 | 145529 | 643 | 50458939 |
Pulmonary embolism | 13.96 | 9.65 | 207 | 145335 | 101497 | 50358085 |
Muscle atrophy | 13.91 | 9.65 | 44 | 145498 | 6077 | 50453505 |
Hyperlipidaemia | 13.85 | 9.65 | 92 | 145450 | 17398 | 50442184 |
Blood ketone body increased | 13.83 | 9.65 | 9 | 145533 | 261 | 50459321 |
Skin necrosis | 13.78 | 9.65 | 7 | 145535 | 10860 | 50448722 |
Croup infectious | 13.73 | 9.65 | 11 | 145531 | 444 | 50459138 |
Grip strength decreased | 13.68 | 9.65 | 9 | 145533 | 12112 | 50447470 |
Premature labour | 13.67 | 9.65 | 8 | 145534 | 11468 | 50448114 |
Rheumatoid nodule | 13.65 | 9.65 | 10 | 145532 | 12725 | 50446857 |
Arteriosclerosis | 13.62 | 9.65 | 57 | 145485 | 9020 | 50450562 |
Haemorrhagic diathesis | 13.56 | 9.65 | 33 | 145509 | 3915 | 50455667 |
Hepatic steatosis | 13.54 | 9.65 | 118 | 145424 | 24266 | 50435316 |
Haemophagocytic lymphohistiocytosis | 13.53 | 9.65 | 4 | 145538 | 8629 | 50450953 |
Photosensitivity reaction | 13.48 | 9.65 | 73 | 145469 | 12838 | 50446744 |
Occult blood | 13.48 | 9.65 | 17 | 145525 | 1190 | 50458392 |
Respiratory depression | 13.44 | 9.65 | 9 | 145533 | 12001 | 50447581 |
Device issue | 13.39 | 9.65 | 23 | 145519 | 19949 | 50439633 |
Pruritus | 13.34 | 9.65 | 967 | 144575 | 282601 | 50176981 |
Therapy non-responder | 13.25 | 9.65 | 89 | 145453 | 50933 | 50408649 |
Posterior reversible encephalopathy syndrome | 13.25 | 9.65 | 14 | 145528 | 14914 | 50444668 |
Haemorrhagic stroke | 13.21 | 9.65 | 39 | 145503 | 5189 | 50454393 |
Affect lability | 13.11 | 9.65 | 56 | 145486 | 8942 | 50450640 |
Nephrolithiasis | 13.06 | 9.65 | 155 | 145387 | 34538 | 50425044 |
Blood pressure fluctuation | 13.03 | 9.65 | 159 | 145383 | 35664 | 50423918 |
Erythema marginatum | 13.03 | 9.65 | 4 | 145538 | 16 | 50459566 |
Neonatal asphyxia | 12.93 | 9.65 | 8 | 145534 | 212 | 50459370 |
Polyglandular autoimmune syndrome type II | 12.89 | 9.65 | 5 | 145537 | 45 | 50459537 |
Endometriosis | 12.88 | 9.65 | 33 | 145509 | 4042 | 50455540 |
Bronchopulmonary aspergillosis | 12.88 | 9.65 | 3 | 145539 | 7589 | 50451993 |
Haemoglobin increased | 12.87 | 9.65 | 28 | 145514 | 3087 | 50456495 |
Blood pressure systolic abnormal | 12.85 | 9.65 | 50 | 145492 | 7656 | 50451926 |
Overdose | 12.66 | 9.65 | 206 | 145336 | 99521 | 50360061 |
Transient ischaemic attack | 12.61 | 9.65 | 145 | 145397 | 32065 | 50427517 |
Brain injury | 12.56 | 9.65 | 42 | 145500 | 5972 | 50453610 |
Sinus pain | 12.56 | 9.65 | 23 | 145519 | 2238 | 50457344 |
Myoglobin blood increased | 12.56 | 9.65 | 17 | 145525 | 1276 | 50458306 |
Cardiac valve fibroelastoma | 12.49 | 9.65 | 3 | 145539 | 3 | 50459579 |
No adverse event | 12.39 | 9.65 | 52 | 145490 | 33526 | 50426056 |
Sopor | 12.34 | 9.65 | 24 | 145518 | 19855 | 50439727 |
Autoimmune nephritis | 12.24 | 9.65 | 9 | 145533 | 319 | 50459263 |
Gastrooesophageal reflux disease | 12.22 | 9.65 | 297 | 145245 | 76131 | 50383451 |
Hypercalcaemia | 12.20 | 9.65 | 31 | 145511 | 23321 | 50436261 |
Pre-eclampsia | 12.12 | 9.65 | 4 | 145538 | 8040 | 50451542 |
Drug ineffective for unapproved indication | 12.11 | 9.65 | 27 | 145515 | 21254 | 50438328 |
Low density lipoprotein abnormal | 12.08 | 9.65 | 7 | 145535 | 164 | 50459418 |
Respiratory tract congestion | 12.05 | 9.65 | 76 | 145466 | 14123 | 50445459 |
Giant cell arteritis | 12.05 | 9.65 | 20 | 145522 | 1800 | 50457782 |
Urine ketone body present | 12.05 | 9.65 | 23 | 145519 | 2310 | 50457272 |
Adverse event | 12.04 | 9.65 | 75 | 145467 | 43688 | 50415894 |
Decubitus ulcer | 12.04 | 9.65 | 6 | 145536 | 9412 | 50450170 |
Agitation | 12.00 | 9.65 | 97 | 145445 | 53287 | 50406295 |
Blood growth hormone increased | 12.00 | 9.65 | 10 | 145532 | 427 | 50459155 |
Hyperparathyroidism secondary | 11.99 | 9.65 | 17 | 145525 | 1333 | 50458249 |
Blood pressure diastolic abnormal | 11.94 | 9.65 | 56 | 145486 | 9305 | 50450277 |
Rotator cuff syndrome | 11.87 | 9.65 | 65 | 145477 | 11479 | 50448103 |
Neurotoxicity | 11.81 | 9.65 | 15 | 145527 | 14725 | 50444857 |
Nightmare | 11.78 | 9.65 | 83 | 145459 | 16003 | 50443579 |
Cardiac neoplasm unspecified | 11.77 | 9.65 | 5 | 145537 | 58 | 50459524 |
Impaired fasting glucose | 11.75 | 9.65 | 7 | 145535 | 173 | 50459409 |
Forced vital capacity decreased | 11.72 | 9.65 | 14 | 145528 | 927 | 50458655 |
Cardiac failure | 11.71 | 9.65 | 294 | 145248 | 75746 | 50383836 |
Blood parathyroid hormone decreased | 11.70 | 9.65 | 3 | 145539 | 7111 | 50452471 |
Osteoarthritis | 11.70 | 9.65 | 269 | 145273 | 68337 | 50391245 |
Musculoskeletal pain | 11.70 | 9.65 | 281 | 145261 | 71896 | 50387686 |
Hemiplegia | 11.59 | 9.65 | 47 | 145495 | 7334 | 50452248 |
Acute hepatic failure | 11.51 | 9.65 | 17 | 145525 | 15660 | 50443922 |
Multi-organ disorder | 11.45 | 9.65 | 16 | 145526 | 1237 | 50458345 |
Erythema multiforme | 11.44 | 9.65 | 54 | 145488 | 8996 | 50450586 |
Tendon pain | 11.44 | 9.65 | 26 | 145516 | 2952 | 50456630 |
Acute myeloid leukaemia | 11.41 | 9.65 | 16 | 145526 | 15058 | 50444524 |
Blood triglycerides decreased | 11.40 | 9.65 | 5 | 145537 | 63 | 50459519 |
Duplicate therapy error | 11.33 | 9.65 | 5 | 145537 | 64 | 50459518 |
Diffuse alopecia | 11.16 | 9.65 | 11 | 145531 | 585 | 50458997 |
Hypertriglyceridaemia | 11.16 | 9.65 | 38 | 145504 | 5453 | 50454129 |
Polycystic ovaries | 11.04 | 9.65 | 23 | 145519 | 2461 | 50457121 |
Lower respiratory tract infection | 11.00 | 9.65 | 200 | 145342 | 95001 | 50364581 |
Sleep apnoea syndrome | 11.00 | 9.65 | 111 | 145431 | 23757 | 50435825 |
Aspergillus infection | 10.99 | 9.65 | 3 | 145539 | 6818 | 50452764 |
Campylobacter test positive | 10.94 | 9.65 | 4 | 145538 | 30 | 50459552 |
Total bile acids increased | 10.86 | 9.65 | 6 | 145536 | 128 | 50459454 |
Product residue present | 10.86 | 9.65 | 29 | 145513 | 3643 | 50455939 |
Injection site pain | 10.81 | 9.65 | 240 | 145302 | 110784 | 50348798 |
Abdominal pain upper | 10.80 | 9.65 | 561 | 144981 | 158748 | 50300834 |
Carotid artery stenosis | 10.75 | 9.65 | 34 | 145508 | 4697 | 50454885 |
BRAF V600E mutation positive | 10.72 | 9.65 | 4 | 145538 | 32 | 50459550 |
Thrombotic microangiopathy | 10.65 | 9.65 | 6 | 145536 | 8785 | 50450797 |
Ascites | 10.64 | 9.65 | 60 | 145482 | 35801 | 50423781 |
Diabetic nephropathy | 10.64 | 9.65 | 16 | 145526 | 1323 | 50458259 |
Sinus disorder | 10.60 | 9.65 | 90 | 145452 | 18368 | 50441214 |
Sneezing | 10.60 | 9.65 | 73 | 145469 | 13971 | 50445611 |
Hypertrophic cardiomyopathy | 10.59 | 9.65 | 16 | 145526 | 1329 | 50458253 |
Bronchopulmonary aspergillosis allergic | 10.58 | 9.65 | 15 | 145527 | 1176 | 50458406 |
Mydriasis | 10.56 | 9.65 | 9 | 145533 | 10618 | 50448964 |
Bladder cancer | 10.55 | 9.65 | 27 | 145515 | 3305 | 50456277 |
Encephalitis | 10.55 | 9.65 | 4 | 145538 | 7376 | 50452206 |
Pseudophaeochromocytoma | 10.51 | 9.65 | 5 | 145537 | 77 | 50459505 |
Abortion induced | 10.46 | 9.65 | 7 | 145535 | 9337 | 50450245 |
Tri-iodothyronine free decreased | 10.45 | 9.65 | 8 | 145534 | 302 | 50459280 |
Tendonitis | 10.43 | 9.65 | 83 | 145459 | 16622 | 50442960 |
Blood cholesterol decreased | 10.42 | 9.65 | 12 | 145530 | 764 | 50458818 |
Sensory loss | 10.39 | 9.65 | 47 | 145495 | 7691 | 50451891 |
Therapeutic product effect incomplete | 10.34 | 9.65 | 193 | 145349 | 91322 | 50368260 |
Haematuria | 10.34 | 9.65 | 116 | 145426 | 25497 | 50434085 |
Endometrial disorder | 10.31 | 9.65 | 11 | 145531 | 643 | 50458939 |
Pulseless electrical activity | 10.30 | 9.65 | 43 | 145499 | 6798 | 50452784 |
Injection site swelling | 10.29 | 9.65 | 74 | 145468 | 41699 | 50417883 |
Monocyte count decreased | 10.24 | 9.65 | 19 | 145523 | 1867 | 50457715 |
Vascular pseudoaneurysm | 10.24 | 9.65 | 16 | 145526 | 1368 | 50458214 |
Sudden hearing loss | 10.24 | 9.65 | 14 | 145528 | 1061 | 50458521 |
Thyroid disorder | 10.23 | 9.65 | 67 | 145475 | 12610 | 50446972 |
Pulmonary haemorrhage | 10.19 | 9.65 | 3 | 145539 | 6489 | 50453093 |
Vitamin B12 decreased | 10.18 | 9.65 | 24 | 145518 | 2791 | 50456791 |
Hypercholesterolaemia | 10.15 | 9.65 | 63 | 145479 | 11640 | 50447942 |
Mental disorder | 10.15 | 9.65 | 31 | 145511 | 21960 | 50437622 |
Blood creatine phosphokinase MM increased | 10.12 | 9.65 | 4 | 145538 | 38 | 50459544 |
Enthesopathy | 10.12 | 9.65 | 4 | 145538 | 7189 | 50452393 |
Knee arthroplasty | 10.09 | 9.65 | 61 | 145481 | 35785 | 50423797 |
Osteogenesis imperfecta | 10.00 | 9.65 | 8 | 145534 | 322 | 50459260 |
Product dispensing issue | 9.96 | 9.65 | 5 | 145537 | 87 | 50459495 |
International normalised ratio increased | 9.95 | 9.65 | 177 | 145365 | 42975 | 50416607 |
Restless legs syndrome | 9.93 | 9.65 | 79 | 145463 | 15818 | 50443764 |
Amyotrophy | 9.90 | 9.65 | 6 | 145536 | 153 | 50459429 |
Infusion site scar | 9.88 | 9.65 | 8 | 145534 | 328 | 50459254 |
Hypomagnesaemia | 9.87 | 9.65 | 106 | 145436 | 23050 | 50436532 |
Hepatic encephalopathy | 9.78 | 9.65 | 8 | 145534 | 9628 | 50449954 |
Urea urine increased | 9.77 | 9.65 | 3 | 145539 | 12 | 50459570 |
Basophil count increased | 9.74 | 9.65 | 12 | 145530 | 820 | 50458762 |
Atelectasis | 9.74 | 9.65 | 24 | 145518 | 18246 | 50441336 |
Calculus bladder | 9.74 | 9.65 | 10 | 145532 | 559 | 50459023 |
Eczema | 9.71 | 9.65 | 104 | 145438 | 22598 | 50436984 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myalgia | 1088.61 | 10.24 | 1479 | 128787 | 72540 | 29371721 |
Rhabdomyolysis | 941.01 | 10.24 | 1246 | 129020 | 59562 | 29384699 |
Blood creatine phosphokinase increased | 452.46 | 10.24 | 713 | 129553 | 39931 | 29404330 |
Toxicity to various agents | 331.66 | 10.24 | 176 | 130090 | 173485 | 29270776 |
Myopathy | 238.14 | 10.24 | 262 | 130004 | 10271 | 29433990 |
Death | 208.66 | 10.24 | 790 | 129476 | 341294 | 29102967 |
Drug abuse | 206.61 | 10.24 | 49 | 130217 | 79834 | 29364427 |
High density lipoprotein decreased | 204.62 | 10.24 | 140 | 130126 | 2839 | 29441422 |
Completed suicide | 189.64 | 10.24 | 80 | 130186 | 90166 | 29354095 |
Low density lipoprotein increased | 170.83 | 10.24 | 140 | 130126 | 3764 | 29440497 |
Blood triglycerides increased | 138.31 | 10.24 | 222 | 130044 | 12612 | 29431649 |
Rheumatoid factor negative | 128.63 | 10.24 | 66 | 130200 | 764 | 29443497 |
Low density lipoprotein decreased | 123.99 | 10.24 | 69 | 130197 | 951 | 29443310 |
Neutropenia | 118.43 | 10.24 | 252 | 130014 | 131459 | 29312802 |
Foetal exposure during pregnancy | 112.22 | 10.24 | 10 | 130256 | 33857 | 29410404 |
Tendon rupture | 109.64 | 10.24 | 137 | 130129 | 6158 | 29438103 |
Pyrexia | 101.36 | 10.24 | 797 | 129469 | 286825 | 29157436 |
Angina pectoris | 95.60 | 10.24 | 305 | 129961 | 27545 | 29416716 |
Acute kidney injury | 89.82 | 10.24 | 1653 | 128613 | 263614 | 29180647 |
Blood cholesterol increased | 86.82 | 10.24 | 204 | 130062 | 15391 | 29428870 |
Bone erosion | 82.91 | 10.24 | 80 | 130186 | 2680 | 29441581 |
Overdose | 82.84 | 10.24 | 140 | 130126 | 79679 | 29364582 |
Off label use | 78.36 | 10.24 | 898 | 129368 | 299902 | 29144359 |
Asthma | 78.25 | 10.24 | 326 | 129940 | 33523 | 29410738 |
Pneumonia | 76.13 | 10.24 | 975 | 129291 | 319197 | 29125064 |
Full blood count abnormal | 75.67 | 10.24 | 189 | 130077 | 14824 | 29429437 |
Myocardial infarction | 75.45 | 10.24 | 780 | 129486 | 109516 | 29334745 |
Red blood cell sedimentation rate abnormal | 75.37 | 10.24 | 70 | 130196 | 2233 | 29442028 |
Intentional overdose | 73.42 | 10.24 | 39 | 130227 | 38489 | 29405772 |
Febrile neutropenia | 71.45 | 10.24 | 254 | 130012 | 111986 | 29332275 |
Sepsis | 70.99 | 10.24 | 355 | 129911 | 142327 | 29301934 |
Leukopenia | 68.91 | 10.24 | 85 | 130181 | 55118 | 29389143 |
Blood pressure systolic increased | 67.68 | 10.24 | 195 | 130071 | 16650 | 29427611 |
Chest discomfort | 67.55 | 10.24 | 389 | 129877 | 45594 | 29398667 |
Coronary artery disease | 65.68 | 10.24 | 375 | 129891 | 43815 | 29400446 |
Muscle spasms | 63.32 | 10.24 | 497 | 129769 | 64585 | 29379676 |
Muscular weakness | 62.11 | 10.24 | 477 | 129789 | 61575 | 29382686 |
Chromaturia | 61.22 | 10.24 | 158 | 130108 | 12644 | 29431617 |
Diabetes mellitus | 61.17 | 10.24 | 341 | 129925 | 39490 | 29404771 |
Coronary artery occlusion | 60.55 | 10.24 | 136 | 130130 | 9958 | 29434303 |
Mucosal inflammation | 60.17 | 10.24 | 32 | 130234 | 31563 | 29412698 |
Pancytopenia | 57.85 | 10.24 | 181 | 130085 | 82987 | 29361274 |
Arthralgia | 57.64 | 10.24 | 899 | 129367 | 138718 | 29305543 |
Seizure | 57.09 | 10.24 | 214 | 130052 | 92909 | 29351352 |
Disease progression | 55.77 | 10.24 | 180 | 130086 | 81736 | 29362525 |
Computerised tomogram coronary artery abnormal | 55.29 | 10.24 | 24 | 130242 | 184 | 29444077 |
Cardiac failure | 55.26 | 10.24 | 563 | 129703 | 78724 | 29365537 |
Multiple organ dysfunction syndrome | 54.80 | 10.24 | 123 | 130143 | 62993 | 29381268 |
Erectile dysfunction | 54.46 | 10.24 | 189 | 130077 | 17820 | 29426441 |
Thrombocytopenia | 53.87 | 10.24 | 360 | 129906 | 134463 | 29309798 |
Septic shock | 53.43 | 10.24 | 123 | 130143 | 62437 | 29381824 |
Cardiac failure chronic | 52.83 | 10.24 | 99 | 130167 | 6368 | 29437893 |
White blood cell count decreased | 52.12 | 10.24 | 190 | 130076 | 83172 | 29361089 |
Blood pressure increased | 50.45 | 10.24 | 522 | 129744 | 73281 | 29370980 |
Drug dependence | 50.16 | 10.24 | 15 | 130251 | 20966 | 29423295 |
Pain in extremity | 49.39 | 10.24 | 721 | 129545 | 109712 | 29334549 |
Productive cough | 48.91 | 10.24 | 269 | 129997 | 30990 | 29413271 |
Angina unstable | 47.80 | 10.24 | 130 | 130136 | 10735 | 29433526 |
Bone marrow failure | 47.74 | 10.24 | 31 | 130235 | 27418 | 29416843 |
Malignant neoplasm progression | 46.40 | 10.24 | 168 | 130098 | 73691 | 29370570 |
Acute coronary syndrome | 46 | 10.24 | 139 | 130127 | 12186 | 29432075 |
Diastolic dysfunction | 45.78 | 10.24 | 81 | 130185 | 4983 | 29439278 |
Orbital myositis | 44.64 | 10.24 | 18 | 130248 | 112 | 29444149 |
5-hydroxyindolacetic acid in urine increased | 43.50 | 10.24 | 21 | 130245 | 211 | 29444050 |
Cytomegalovirus infection | 43.49 | 10.24 | 24 | 130242 | 23191 | 29421070 |
Conjunctivitis allergic | 43.35 | 10.24 | 30 | 130236 | 620 | 29443641 |
Ascites | 43.00 | 10.24 | 59 | 130207 | 36560 | 29407701 |
Hepatic enzyme increased | 40.87 | 10.24 | 272 | 129994 | 33527 | 29410734 |
Agitation | 40.55 | 10.24 | 105 | 130161 | 51199 | 29393062 |
Intentional self-injury | 40.42 | 10.24 | 4 | 130262 | 12457 | 29431804 |
Ill-defined disorder | 40.15 | 10.24 | 128 | 130138 | 11550 | 29432711 |
Middle insomnia | 40.09 | 10.24 | 82 | 130184 | 5626 | 29438635 |
Carotid arteriosclerosis | 40.06 | 10.24 | 40 | 130226 | 1398 | 29442863 |
Suicide attempt | 40.01 | 10.24 | 55 | 130211 | 34055 | 29410206 |
Wheezing | 39.89 | 10.24 | 267 | 129999 | 32973 | 29411288 |
Diabetic ketoacidosis | 39.67 | 10.24 | 158 | 130108 | 15915 | 29428346 |
Blood mercury abnormal | 39.61 | 10.24 | 19 | 130247 | 188 | 29444073 |
Gait spastic | 39.46 | 10.24 | 29 | 130237 | 661 | 29443600 |
Acute myocardial infarction | 39.19 | 10.24 | 355 | 129911 | 48083 | 29396178 |
Needle fatigue | 38.39 | 10.24 | 27 | 130239 | 573 | 29443688 |
Coronary artery stenosis | 38.13 | 10.24 | 103 | 130163 | 8470 | 29435791 |
Infection | 38.09 | 10.24 | 191 | 130075 | 76560 | 29367701 |
Euglycaemic diabetic ketoacidosis | 37.67 | 10.24 | 52 | 130214 | 2578 | 29441683 |
Asthenia | 37.54 | 10.24 | 1226 | 129040 | 214024 | 29230237 |
Myositis | 37.47 | 10.24 | 115 | 130151 | 10168 | 29434093 |
Chest pain | 37.43 | 10.24 | 697 | 129569 | 111276 | 29332985 |
Fractured coccyx | 37.42 | 10.24 | 17 | 130249 | 147 | 29444114 |
Hospitalisation | 37.21 | 10.24 | 93 | 130173 | 45895 | 29398366 |
Presyncope | 37.20 | 10.24 | 155 | 130111 | 15934 | 29428327 |
Vascular stent stenosis | 37.02 | 10.24 | 33 | 130233 | 997 | 29443264 |
Amyotrophic lateral sclerosis | 37.00 | 10.24 | 31 | 130235 | 860 | 29443401 |
Premature baby | 36.77 | 10.24 | 15 | 130251 | 17265 | 29426996 |
Psychotic disorder | 36.76 | 10.24 | 22 | 130244 | 20332 | 29423929 |
Respiratory failure | 36.48 | 10.24 | 264 | 130002 | 96867 | 29347394 |
Obstructive airways disorder | 36.30 | 10.24 | 119 | 130147 | 10897 | 29433364 |
Congenital hiatus hernia | 35.74 | 10.24 | 23 | 130243 | 419 | 29443842 |
Myoglobin blood increased | 35.67 | 10.24 | 44 | 130222 | 1951 | 29442310 |
Mycotic allergy | 35.24 | 10.24 | 19 | 130247 | 245 | 29444016 |
General physical health deterioration | 34.68 | 10.24 | 288 | 129978 | 102569 | 29341692 |
Somnolence | 34.50 | 10.24 | 257 | 130009 | 93698 | 29350563 |
Lung diffusion test decreased | 34.31 | 10.24 | 25 | 130241 | 562 | 29443699 |
Hepatojugular reflux | 34.10 | 10.24 | 23 | 130243 | 455 | 29443806 |
Vomiting | 33.75 | 10.24 | 696 | 129570 | 211564 | 29232697 |
Relapsing-remitting multiple sclerosis | 33.61 | 10.24 | 27 | 130239 | 705 | 29443556 |
Sleep disorder due to a general medical condition | 33.31 | 10.24 | 54 | 130212 | 3092 | 29441169 |
Haemorrhagic stroke | 33.02 | 10.24 | 77 | 130189 | 5779 | 29438482 |
Mental status changes | 32.87 | 10.24 | 65 | 130201 | 34862 | 29409399 |
Supine hypertension | 32.28 | 10.24 | 19 | 130247 | 293 | 29443968 |
Hepatic neoplasm | 32.04 | 10.24 | 40 | 130226 | 1796 | 29442465 |
Gait disturbance | 32.02 | 10.24 | 477 | 129789 | 72872 | 29371389 |
Product use in unapproved indication | 31.72 | 10.24 | 238 | 130028 | 86637 | 29357624 |
Muscle disorder | 31.56 | 10.24 | 44 | 130222 | 2202 | 29442059 |
Spirometry abnormal | 31.43 | 10.24 | 20 | 130246 | 357 | 29443904 |
Immune-mediated myositis | 31.35 | 10.24 | 37 | 130229 | 1566 | 29442695 |
Skin laceration | 30.80 | 10.24 | 113 | 130153 | 10949 | 29433312 |
Drug resistance | 30.35 | 10.24 | 30 | 130236 | 21510 | 29422751 |
Hypercholesterolaemia | 30.25 | 10.24 | 85 | 130181 | 7153 | 29437108 |
Arteriosclerosis coronary artery | 30.09 | 10.24 | 109 | 130157 | 10496 | 29433765 |
Plasmapheresis | 29.68 | 10.24 | 18 | 130248 | 294 | 29443967 |
Glycosylated haemoglobin increased | 29.44 | 10.24 | 100 | 130166 | 9326 | 29434935 |
Mite allergy | 29.42 | 10.24 | 18 | 130248 | 299 | 29443962 |
Muscle rupture | 29.38 | 10.24 | 40 | 130226 | 1957 | 29442304 |
Drug withdrawal syndrome | 29.04 | 10.24 | 22 | 130244 | 17962 | 29426299 |
Eosinophilia | 29.03 | 10.24 | 182 | 130084 | 21979 | 29422282 |
Neutrophil count decreased | 28.75 | 10.24 | 97 | 130169 | 43470 | 29400791 |
Neutropenic sepsis | 28.74 | 10.24 | 8 | 130258 | 11719 | 29432542 |
Loss of personal independence in daily activities | 28.53 | 10.24 | 201 | 130065 | 25239 | 29419022 |
Candida infection | 28.14 | 10.24 | 16 | 130250 | 15209 | 29429052 |
Haemophagocytic lymphohistiocytosis | 28.02 | 10.24 | 6 | 130260 | 10498 | 29433763 |
Coma | 28.02 | 10.24 | 85 | 130181 | 39365 | 29404896 |
Respiratory arrest | 28.00 | 10.24 | 44 | 130222 | 25789 | 29418472 |
Pancreatitis | 27.93 | 10.24 | 253 | 130013 | 34261 | 29410000 |
Left ventricular enlargement | 27.73 | 10.24 | 23 | 130243 | 629 | 29443632 |
Type 2 diabetes mellitus | 27.70 | 10.24 | 126 | 130140 | 13455 | 29430806 |
Breast pain | 27.34 | 10.24 | 31 | 130235 | 1256 | 29443005 |
Gynaecomastia | 27.28 | 10.24 | 89 | 130177 | 8128 | 29436133 |
Rhinitis perennial | 27.19 | 10.24 | 15 | 130251 | 203 | 29444058 |
Blood thyroid stimulating hormone abnormal | 27.00 | 10.24 | 16 | 130250 | 250 | 29444011 |
Electrocardiogram Q wave abnormal | 26.99 | 10.24 | 17 | 130249 | 298 | 29443963 |
Platelet count decreased | 26.91 | 10.24 | 313 | 129953 | 104359 | 29339902 |
Autoimmune hepatitis | 26.80 | 10.24 | 53 | 130213 | 3549 | 29440712 |
Blood pressure inadequately controlled | 26.70 | 10.24 | 42 | 130224 | 2344 | 29441917 |
Blood glucose increased | 26.69 | 10.24 | 386 | 129880 | 58598 | 29385663 |
Pulmonary function test abnormal | 26.63 | 10.24 | 39 | 130227 | 2043 | 29442218 |
Encephalopathy | 26.52 | 10.24 | 61 | 130205 | 30982 | 29413279 |
Growth hormone deficiency | 26.44 | 10.24 | 15 | 130251 | 215 | 29444046 |
Pericardial disease | 26.34 | 10.24 | 18 | 130248 | 364 | 29443897 |
Serotonin syndrome | 26.31 | 10.24 | 23 | 130243 | 17489 | 29426772 |
Lipoma | 26.30 | 10.24 | 32 | 130234 | 1399 | 29442862 |
Low cardiac output syndrome | 26.29 | 10.24 | 20 | 130246 | 481 | 29443780 |
Bundle branch block left | 26.13 | 10.24 | 66 | 130200 | 5211 | 29439050 |
Nipple inflammation | 26.12 | 10.24 | 10 | 130256 | 53 | 29444208 |
Occult blood | 26.12 | 10.24 | 21 | 130245 | 549 | 29443712 |
N-terminal prohormone brain natriuretic peptide increased | 25.89 | 10.24 | 37 | 130229 | 1895 | 29442366 |
Coronary artery restenosis | 25.87 | 10.24 | 27 | 130239 | 995 | 29443266 |
Hypertonic bladder | 25.85 | 10.24 | 32 | 130234 | 1424 | 29442837 |
Neuroleptic malignant syndrome | 25.76 | 10.24 | 20 | 130246 | 16128 | 29428133 |
Hyperthyroidism | 25.73 | 10.24 | 90 | 130176 | 8518 | 29435743 |
Blood cholesterol decreased | 25.73 | 10.24 | 26 | 130240 | 922 | 29443339 |
Ventricular hypokinesia | 25.71 | 10.24 | 60 | 130206 | 4505 | 29439756 |
Muscle discomfort | 25.67 | 10.24 | 10 | 130256 | 56 | 29444205 |
Rales | 25.53 | 10.24 | 82 | 130184 | 7428 | 29436833 |
Fatigue | 25.50 | 10.24 | 1669 | 128597 | 315152 | 29129109 |
Stenosis | 25.46 | 10.24 | 27 | 130239 | 1014 | 29443247 |
Pulmonary valve disease | 25.32 | 10.24 | 16 | 130250 | 282 | 29443979 |
Diabetic neuropathy | 25.29 | 10.24 | 53 | 130213 | 3700 | 29440561 |
Dyslipidaemia | 25.15 | 10.24 | 71 | 130195 | 5990 | 29438271 |
Dizziness | 24.93 | 10.24 | 1047 | 129219 | 188637 | 29255624 |
Left ventricular dysfunction | 24.84 | 10.24 | 91 | 130175 | 8811 | 29435450 |
Cardio-respiratory arrest | 24.49 | 10.24 | 127 | 130139 | 50474 | 29393787 |
Tricuspid valve incompetence | 24.43 | 10.24 | 87 | 130179 | 8307 | 29435954 |
Respiratory distress | 24.39 | 10.24 | 67 | 130199 | 32039 | 29412222 |
Diabetes mellitus inadequate control | 24.32 | 10.24 | 112 | 130154 | 12022 | 29432239 |
Brain natriuretic peptide abnormal | 24.19 | 10.24 | 16 | 130250 | 306 | 29443955 |
Product substitution issue | 24.12 | 10.24 | 92 | 130174 | 9080 | 29435181 |
Lipoprotein (a) increased | 24.10 | 10.24 | 9 | 130257 | 44 | 29444217 |
Chronic obstructive pulmonary disease | 23.98 | 10.24 | 281 | 129985 | 40674 | 29403587 |
Interstitial lung disease | 23.89 | 10.24 | 372 | 129894 | 57346 | 29386915 |
Micturition urgency | 23.86 | 10.24 | 63 | 130203 | 5110 | 29439151 |
Nodular rash | 23.83 | 10.24 | 11 | 130255 | 99 | 29444162 |
Blood uric acid increased | 23.38 | 10.24 | 67 | 130199 | 5701 | 29438560 |
Transient ischaemic attack | 23.32 | 10.24 | 179 | 130087 | 23091 | 29421170 |
Muscle injury | 23.19 | 10.24 | 27 | 130239 | 1126 | 29443135 |
Exercise tolerance decreased | 23.16 | 10.24 | 55 | 130211 | 4176 | 29440085 |
Thrombotic microangiopathy | 23.07 | 10.24 | 5 | 130261 | 8676 | 29435585 |
Food aversion | 23.06 | 10.24 | 16 | 130250 | 332 | 29443929 |
N-terminal prohormone brain natriuretic peptide abnormal | 22.94 | 10.24 | 13 | 130253 | 186 | 29444075 |
Cardiac discomfort | 22.80 | 10.24 | 18 | 130248 | 458 | 29443803 |
Seronegative arthritis | 22.66 | 10.24 | 24 | 130242 | 900 | 29443361 |
Body temperature decreased | 22.55 | 10.24 | 100 | 130166 | 10564 | 29433697 |
Respiratory depression | 22.54 | 10.24 | 16 | 130250 | 13507 | 29430754 |
Pulmonary arterial pressure abnormal | 22.52 | 10.24 | 13 | 130253 | 193 | 29444068 |
Melanoderma | 22.38 | 10.24 | 12 | 130254 | 153 | 29444108 |
Dust allergy | 22.37 | 10.24 | 18 | 130248 | 471 | 29443790 |
Neurotoxicity | 22.19 | 10.24 | 19 | 130247 | 14594 | 29429667 |
Muscle rigidity | 22.01 | 10.24 | 7 | 130259 | 9404 | 29434857 |
Hepatitis C | 21.98 | 10.24 | 6 | 130260 | 8904 | 29435357 |
Total cholesterol/HDL ratio increased | 21.97 | 10.24 | 12 | 130254 | 159 | 29444102 |
Cardiac arrest | 21.97 | 10.24 | 256 | 130010 | 85335 | 29358926 |
Fractional exhaled nitric oxide increased | 21.95 | 10.24 | 16 | 130250 | 360 | 29443901 |
Neoplasm progression | 21.83 | 10.24 | 30 | 130236 | 18582 | 29425679 |
Abnormal behaviour | 21.79 | 10.24 | 43 | 130223 | 23084 | 29421177 |
Device related infection | 21.77 | 10.24 | 22 | 130244 | 15614 | 29428647 |
Guillain-Barre syndrome | 21.73 | 10.24 | 60 | 130206 | 4998 | 29439263 |
Helicobacter gastritis | 21.58 | 10.24 | 25 | 130241 | 1037 | 29443224 |
Aggression | 21.54 | 10.24 | 82 | 130184 | 35459 | 29408802 |
Ileus | 21.54 | 10.24 | 19 | 130247 | 14383 | 29429878 |
Chronic kidney disease | 21.38 | 10.24 | 250 | 130016 | 36166 | 29408095 |
Right atrial enlargement | 20.73 | 10.24 | 13 | 130253 | 226 | 29444035 |
Prinzmetal angina | 20.51 | 10.24 | 22 | 130244 | 837 | 29443424 |
Posterior reversible encephalopathy syndrome | 20.42 | 10.24 | 7 | 130259 | 8969 | 29435292 |
Carotid artery stenosis | 20.18 | 10.24 | 54 | 130212 | 4415 | 29439846 |
Musculoskeletal stiffness | 20.18 | 10.24 | 253 | 130013 | 37205 | 29407056 |
Polymyositis | 20.15 | 10.24 | 27 | 130239 | 1301 | 29442960 |
Arteriosclerosis | 20.06 | 10.24 | 94 | 130172 | 10162 | 29434099 |
Electrocardiogram QRS complex abnormal | 20.03 | 10.24 | 14 | 130252 | 294 | 29443967 |
Substance abuse | 20 | 10.24 | 3 | 130263 | 6784 | 29437477 |
Transaminases abnormal | 19.87 | 10.24 | 13 | 130253 | 244 | 29444017 |
Pancreatitis acute | 19.85 | 10.24 | 179 | 130087 | 24206 | 29420055 |
Hepatic encephalopathy | 19.73 | 10.24 | 17 | 130249 | 13018 | 29431243 |
Immune reconstitution inflammatory syndrome | 19.73 | 10.24 | 5 | 130261 | 7797 | 29436464 |
Paraplegia | 19.72 | 10.24 | 38 | 130228 | 2496 | 29441765 |
Mean platelet volume increased | 19.68 | 10.24 | 16 | 130250 | 425 | 29443836 |
Toxic epidermal necrolysis | 19.59 | 10.24 | 31 | 130235 | 18122 | 29426139 |
Atrial fibrillation | 19.47 | 10.24 | 606 | 129660 | 105040 | 29339221 |
Bacteraemia | 19.46 | 10.24 | 26 | 130240 | 16297 | 29427964 |
Aortic aneurysm | 19.43 | 10.24 | 66 | 130200 | 6154 | 29438107 |
Ventricular hyperkinesia | 19.42 | 10.24 | 12 | 130254 | 203 | 29444058 |
Staphylococcal infection | 19.36 | 10.24 | 65 | 130201 | 29175 | 29415086 |
Psoriasis | 19.25 | 10.24 | 222 | 130044 | 32005 | 29412256 |
Walking disability | 19.21 | 10.24 | 20 | 130246 | 735 | 29443526 |
Mitral valve incompetence | 19.21 | 10.24 | 112 | 130154 | 13181 | 29431080 |
Poisoning | 19.20 | 10.24 | 10 | 130256 | 9983 | 29434278 |
Dyspnoea | 19.19 | 10.24 | 1679 | 128587 | 325053 | 29119208 |
Discomfort | 19.18 | 10.24 | 121 | 130145 | 14642 | 29429619 |
Physical examination abnormal | 19.06 | 10.24 | 13 | 130253 | 262 | 29443999 |
Depressed level of consciousness | 18.85 | 10.24 | 91 | 130175 | 36851 | 29407410 |
Diabetic metabolic decompensation | 18.80 | 10.24 | 27 | 130239 | 1389 | 29442872 |
Inspiratory capacity abnormal | 18.68 | 10.24 | 9 | 130257 | 90 | 29444171 |
Nipple disorder | 18.67 | 10.24 | 11 | 130255 | 170 | 29444091 |
Miosis | 18.65 | 10.24 | 6 | 130260 | 8003 | 29436258 |
Oxygen saturation increased | 18.60 | 10.24 | 13 | 130253 | 273 | 29443988 |
Meningitis eosinophilic | 18.59 | 10.24 | 6 | 130260 | 17 | 29444244 |
Dermatomyositis | 18.55 | 10.24 | 23 | 130243 | 1025 | 29443236 |
Drug interaction | 18.47 | 10.24 | 1054 | 129212 | 196331 | 29247930 |
Lymphomatoid papulosis | 18.28 | 10.24 | 11 | 130255 | 177 | 29444084 |
Blood pressure fluctuation | 18.27 | 10.24 | 150 | 130116 | 19744 | 29424517 |
Enterococcal infection | 17.88 | 10.24 | 7 | 130259 | 8261 | 29436000 |
Atrial septal defect | 17.86 | 10.24 | 4 | 130262 | 6785 | 29437476 |
Tendonitis | 17.86 | 10.24 | 76 | 130190 | 7885 | 29436376 |
Plantar fasciitis | 17.86 | 10.24 | 25 | 130241 | 1256 | 29443005 |
Vascular stent thrombosis | 17.75 | 10.24 | 37 | 130229 | 2573 | 29441688 |
Blood creatine phosphokinase | 17.73 | 10.24 | 8 | 130258 | 68 | 29444193 |
Muscle atrophy | 17.72 | 10.24 | 66 | 130200 | 6440 | 29437821 |
Hypochromasia | 17.70 | 10.24 | 13 | 130253 | 296 | 29443965 |
Haematuria | 17.70 | 10.24 | 283 | 129983 | 43856 | 29400405 |
Malignant melanoma in situ | 17.69 | 10.24 | 24 | 130242 | 1170 | 29443091 |
Akathisia | 17.68 | 10.24 | 4 | 130262 | 6738 | 29437523 |
Decreased ventricular preload | 17.65 | 10.24 | 6 | 130260 | 21 | 29444240 |
Mitral valve thickening | 17.64 | 10.24 | 14 | 130252 | 359 | 29443902 |
Intermittent claudication | 17.58 | 10.24 | 32 | 130234 | 2013 | 29442248 |
Cerebral infarction | 17.54 | 10.24 | 176 | 130090 | 24499 | 29419762 |
Stomatitis | 17.48 | 10.24 | 94 | 130172 | 37019 | 29407242 |
Dyspepsia | 17.32 | 10.24 | 206 | 130060 | 29919 | 29414342 |
Pruritus | 17.19 | 10.24 | 653 | 129613 | 116196 | 29328065 |
Mycobacterium test positive | 17.12 | 10.24 | 14 | 130252 | 375 | 29443886 |
Brain natriuretic peptide increased | 17.02 | 10.24 | 49 | 130217 | 4181 | 29440080 |
Aspergillus infection | 17.01 | 10.24 | 13 | 130253 | 10568 | 29433693 |
Pneumocystis jirovecii pneumonia | 16.87 | 10.24 | 30 | 130236 | 16749 | 29427512 |
Inappropriate antidiuretic hormone secretion | 16.86 | 10.24 | 14 | 130252 | 10918 | 29433343 |
Drug-induced liver injury | 16.64 | 10.24 | 157 | 130109 | 21498 | 29422763 |
Ejection fraction decreased | 16.62 | 10.24 | 124 | 130142 | 15854 | 29428407 |
Left ventricular hypertrophy | 16.62 | 10.24 | 66 | 130200 | 6637 | 29437624 |
Transplant rejection | 16.57 | 10.24 | 10 | 130256 | 9202 | 29435059 |
Electrocardiogram abnormal | 16.50 | 10.24 | 70 | 130196 | 7252 | 29437009 |
Product use issue | 16.44 | 10.24 | 146 | 130120 | 51298 | 29392963 |
Anaemia | 16.36 | 10.24 | 721 | 129545 | 200230 | 29244031 |
Pollakiuria | 16.33 | 10.24 | 129 | 130137 | 16787 | 29427474 |
Histamine level increased | 16.31 | 10.24 | 7 | 130259 | 52 | 29444209 |
Dysphagia | 16.22 | 10.24 | 159 | 130107 | 54767 | 29389494 |
Lipids increased | 16.21 | 10.24 | 19 | 130247 | 798 | 29443463 |
Paraesthesia | 16.21 | 10.24 | 330 | 129936 | 53515 | 29390746 |
Musculoskeletal discomfort | 16.18 | 10.24 | 63 | 130203 | 6278 | 29437983 |
Mania | 16.16 | 10.24 | 9 | 130257 | 8654 | 29435607 |
Cytomegalovirus viraemia | 16.08 | 10.24 | 4 | 130262 | 6316 | 29437945 |
No adverse event | 16.04 | 10.24 | 33 | 130233 | 17445 | 29426816 |
Lipids abnormal | 15.98 | 10.24 | 12 | 130254 | 283 | 29443978 |
Acute respiratory distress syndrome | 15.87 | 10.24 | 50 | 130216 | 22885 | 29421376 |
Unresponsive to stimuli | 15.86 | 10.24 | 57 | 130209 | 25069 | 29419192 |
Ureteric cancer | 15.79 | 10.24 | 10 | 130256 | 177 | 29444084 |
Oxygen consumption decreased | 15.69 | 10.24 | 10 | 130256 | 179 | 29444082 |
Tumour lysis syndrome | 15.67 | 10.24 | 23 | 130243 | 13861 | 29430400 |
Arterial spasm | 15.64 | 10.24 | 8 | 130258 | 92 | 29444169 |
Hemiplegia | 15.61 | 10.24 | 64 | 130202 | 6530 | 29437731 |
Cytokine release syndrome | 15.53 | 10.24 | 21 | 130245 | 13098 | 29431163 |
Weight decreased | 15.52 | 10.24 | 813 | 129453 | 150092 | 29294169 |
Aortic valve incompetence | 15.49 | 10.24 | 53 | 130213 | 4960 | 29439301 |
Tachycardia | 15.47 | 10.24 | 225 | 130041 | 72185 | 29372076 |
Ventricular arrhythmia | 15.40 | 10.24 | 50 | 130216 | 4554 | 29439707 |
Bronchopulmonary aspergillosis | 15.40 | 10.24 | 19 | 130247 | 12325 | 29431936 |
Drug intolerance | 15.40 | 10.24 | 299 | 129967 | 48080 | 29396181 |
Monoparesis | 15.38 | 10.24 | 29 | 130237 | 1874 | 29442387 |
Delusion | 15.37 | 10.24 | 16 | 130250 | 11200 | 29433061 |
Peritonitis | 15.36 | 10.24 | 26 | 130240 | 14798 | 29429463 |
Body temperature increased | 15.33 | 10.24 | 25 | 130241 | 14440 | 29429821 |
Cardiovascular somatic symptom disorder | 15.20 | 10.24 | 6 | 130260 | 35 | 29444226 |
Skin ulcer | 15.18 | 10.24 | 138 | 130128 | 18702 | 29425559 |
Angiocardiogram | 15.18 | 10.24 | 10 | 130256 | 190 | 29444071 |
Confusional state | 15.15 | 10.24 | 438 | 129828 | 127439 | 29316822 |
Blood pressure systolic abnormal | 15.12 | 10.24 | 31 | 130235 | 2130 | 29442131 |
AST/ALT ratio abnormal | 15.04 | 10.24 | 5 | 130261 | 16 | 29444245 |
Sedation | 15.03 | 10.24 | 34 | 130232 | 17371 | 29426890 |
Dyspnoea exertional | 15.02 | 10.24 | 235 | 130031 | 36255 | 29408006 |
Troponin increased | 15.02 | 10.24 | 80 | 130186 | 9103 | 29435158 |
Drug ineffective | 14.98 | 10.24 | 1387 | 128879 | 361783 | 29082478 |
Aldolase increased | 14.98 | 10.24 | 7 | 130259 | 65 | 29444196 |
Low density lipoprotein abnormal | 14.96 | 10.24 | 11 | 130255 | 251 | 29444010 |
Blood pressure diastolic abnormal | 14.88 | 10.24 | 34 | 130232 | 2517 | 29441744 |
Haemolysis | 14.86 | 10.24 | 6 | 130260 | 6950 | 29437311 |
Cytopenia | 14.75 | 10.24 | 13 | 130253 | 9846 | 29434415 |
Withdrawal syndrome | 14.70 | 10.24 | 16 | 130250 | 10976 | 29433285 |
Pneumonia aspiration | 14.69 | 10.24 | 98 | 130168 | 36639 | 29407622 |
Coagulopathy | 14.65 | 10.24 | 36 | 130230 | 17871 | 29426390 |
Lipase increased | 14.58 | 10.24 | 74 | 130192 | 8263 | 29435998 |
Carcinoid tumour | 14.52 | 10.24 | 10 | 130256 | 205 | 29444056 |
Osteonecrosis of jaw | 14.46 | 10.24 | 32 | 130234 | 16478 | 29427783 |
Base excess decreased | 14.39 | 10.24 | 10 | 130256 | 208 | 29444053 |
Very low density lipoprotein increased | 14.39 | 10.24 | 5 | 130261 | 19 | 29444242 |
Hepatic function abnormal | 14.37 | 10.24 | 248 | 130018 | 39011 | 29405250 |
Cerebral haemorrhage | 14.34 | 10.24 | 206 | 130060 | 31220 | 29413041 |
Mesenteric artery thrombosis | 14.22 | 10.24 | 13 | 130253 | 406 | 29443855 |
Eczema | 14.21 | 10.24 | 107 | 130159 | 13719 | 29430542 |
Haemoglobin decreased | 14.18 | 10.24 | 366 | 129900 | 108009 | 29336252 |
Pulmonary haemorrhage | 14.14 | 10.24 | 12 | 130254 | 9258 | 29435003 |
Syncope | 14.00 | 10.24 | 463 | 129803 | 80908 | 29363353 |
Cough | 13.90 | 10.24 | 687 | 129579 | 126040 | 29318221 |
Poisoning deliberate | 13.88 | 10.24 | 4 | 130262 | 5727 | 29438534 |
Prostatic haemorrhage | 13.79 | 10.24 | 10 | 130256 | 223 | 29444038 |
Retroperitoneal fibrosis | 13.76 | 10.24 | 11 | 130255 | 285 | 29443976 |
Expired product administered | 13.75 | 10.24 | 35 | 130231 | 2776 | 29441485 |
Stent placement | 13.72 | 10.24 | 46 | 130220 | 4260 | 29440001 |
Albuminuria | 13.70 | 10.24 | 12 | 130254 | 354 | 29443907 |
Drug-disease interaction | 13.64 | 10.24 | 12 | 130254 | 356 | 29443905 |
Blood triglycerides | 13.29 | 10.24 | 3 | 130263 | 0 | 29444261 |
Muscle necrosis | 13.13 | 10.24 | 17 | 130249 | 792 | 29443469 |
Joint swelling | 12.96 | 10.24 | 298 | 129968 | 49332 | 29394929 |
Flatulence | 12.92 | 10.24 | 127 | 130139 | 17582 | 29426679 |
Plasma cell myeloma | 12.91 | 10.24 | 103 | 130163 | 37012 | 29407249 |
Hypercreatinaemia | 12.91 | 10.24 | 8 | 130258 | 136 | 29444125 |
Accident at work | 12.86 | 10.24 | 15 | 130251 | 627 | 29443634 |
Blood cholesterol abnormal | 12.77 | 10.24 | 23 | 130243 | 1435 | 29442826 |
Tongue dry | 12.68 | 10.24 | 9 | 130257 | 194 | 29444067 |
Dry mouth | 12.54 | 10.24 | 149 | 130117 | 21635 | 29422626 |
Hepatocellular injury | 12.54 | 10.24 | 146 | 130120 | 21097 | 29423164 |
Progressive multifocal leukoencephalopathy | 12.45 | 10.24 | 12 | 130254 | 8707 | 29435554 |
Peripheral swelling | 12.37 | 10.24 | 368 | 129898 | 63371 | 29380890 |
Aplastic anaemia | 12.37 | 10.24 | 9 | 130257 | 7501 | 29436760 |
Ischaemic stroke | 12.36 | 10.24 | 116 | 130150 | 15861 | 29428400 |
Urine odour abnormal | 12.30 | 10.24 | 18 | 130248 | 942 | 29443319 |
Lethargy | 12.30 | 10.24 | 106 | 130160 | 37474 | 29406787 |
Cardiac autonomic neuropathy | 12.28 | 10.24 | 6 | 130260 | 62 | 29444199 |
Medication error | 12.18 | 10.24 | 50 | 130216 | 21161 | 29423100 |
Hepatic failure | 12.13 | 10.24 | 85 | 130181 | 31427 | 29412834 |
High density lipoprotein increased | 12.10 | 10.24 | 11 | 130255 | 341 | 29443920 |
Gait inability | 12.08 | 10.24 | 129 | 130137 | 18246 | 29426015 |
Peripheral arterial occlusive disease | 11.81 | 10.24 | 49 | 130217 | 5027 | 29439234 |
Chronic cutaneous lupus erythematosus | 11.80 | 10.24 | 6 | 130260 | 68 | 29444193 |
Mucormycosis | 11.77 | 10.24 | 4 | 130262 | 5154 | 29439107 |
Hallucination, auditory | 11.72 | 10.24 | 15 | 130251 | 9578 | 29434683 |
Generalised tonic-clonic seizure | 11.70 | 10.24 | 44 | 130222 | 19095 | 29425166 |
Oedema genital | 11.63 | 10.24 | 11 | 130255 | 359 | 29443902 |
Nervous system disorder | 11.57 | 10.24 | 24 | 130242 | 12650 | 29431611 |
Abscess of salivary gland | 11.55 | 10.24 | 4 | 130262 | 15 | 29444246 |
Left atrial dilatation | 11.51 | 10.24 | 24 | 130242 | 1669 | 29442592 |
Epilepsy | 11.51 | 10.24 | 42 | 130224 | 18390 | 29425871 |
Blood chloride increased | 11.50 | 10.24 | 32 | 130234 | 2677 | 29441584 |
Nasal inflammation | 11.50 | 10.24 | 9 | 130257 | 226 | 29444035 |
Photosensitivity reaction | 11.48 | 10.24 | 75 | 130191 | 9183 | 29435078 |
Acute hepatic failure | 11.45 | 10.24 | 22 | 130244 | 11930 | 29432331 |
Obsessive-compulsive disorder | 11.44 | 10.24 | 3 | 130263 | 4573 | 29439688 |
Myoglobinuria | 11.42 | 10.24 | 15 | 130251 | 709 | 29443552 |
Breath sounds abnormal | 11.40 | 10.24 | 51 | 130215 | 5406 | 29438855 |
Musculoskeletal toxicity | 11.40 | 10.24 | 7 | 130259 | 117 | 29444144 |
Cardiac aneurysm | 11.40 | 10.24 | 16 | 130250 | 806 | 29443455 |
Stevens-Johnson syndrome | 11.39 | 10.24 | 36 | 130230 | 16461 | 29427800 |
Chemical burns of eye | 11.35 | 10.24 | 4 | 130262 | 16 | 29444245 |
Hyponatraemia | 11.24 | 10.24 | 220 | 130046 | 67413 | 29376848 |
Familial periodic paralysis | 11.15 | 10.24 | 6 | 130260 | 77 | 29444184 |
Colitis ulcerative | 11.05 | 10.24 | 95 | 130171 | 12674 | 29431587 |
Aortic stenosis | 11.03 | 10.24 | 40 | 130226 | 3854 | 29440407 |
Orthostatic hypotension | 10.99 | 10.24 | 150 | 130116 | 22479 | 29421782 |
Reversible airways obstruction | 10.98 | 10.24 | 9 | 130257 | 242 | 29444019 |
Movement disorder | 10.96 | 10.24 | 80 | 130186 | 10157 | 29434104 |
Left atrial enlargement | 10.95 | 10.24 | 15 | 130251 | 738 | 29443523 |
Thrombosis | 10.94 | 10.24 | 129 | 130137 | 42916 | 29401345 |
Forced vital capacity decreased | 10.90 | 10.24 | 14 | 130252 | 647 | 29443614 |
Product odour abnormal | 10.83 | 10.24 | 14 | 130252 | 651 | 29443610 |
Cerebellar atrophy | 10.79 | 10.24 | 12 | 130254 | 476 | 29443785 |
Low birth weight baby | 10.78 | 10.24 | 8 | 130258 | 6600 | 29437661 |
Kidney transplant rejection | 10.77 | 10.24 | 9 | 130257 | 6996 | 29437265 |
Left ventricular dilatation | 10.75 | 10.24 | 14 | 130252 | 656 | 29443605 |
Hypoalbuminaemia | 10.74 | 10.24 | 18 | 130248 | 10287 | 29433974 |
Acute myeloid leukaemia | 10.73 | 10.24 | 37 | 130229 | 16476 | 29427785 |
Hypothermia | 10.73 | 10.24 | 15 | 130251 | 9224 | 29435037 |
Normochromic normocytic anaemia | 10.72 | 10.24 | 38 | 130228 | 3620 | 29440641 |
Echocardiogram abnormal | 10.69 | 10.24 | 16 | 130250 | 855 | 29443406 |
Toxic cataract | 10.64 | 10.24 | 4 | 130262 | 20 | 29444241 |
Cystitis haemorrhagic | 10.63 | 10.24 | 4 | 130262 | 4838 | 29439423 |
Idiopathic interstitial pneumonia | 10.58 | 10.24 | 7 | 130259 | 134 | 29444127 |
Hypoxia | 10.55 | 10.24 | 146 | 130120 | 47233 | 29397028 |
Transaminases increased | 10.52 | 10.24 | 149 | 130117 | 22513 | 29421748 |
Mitral valve disease | 10.48 | 10.24 | 19 | 130247 | 1191 | 29443070 |
Blood bilirubin increased | 10.48 | 10.24 | 97 | 130169 | 33796 | 29410465 |
Polymyalgia rheumatica | 10.47 | 10.24 | 19 | 130247 | 1192 | 29443069 |
Drug hypersensitivity | 10.46 | 10.24 | 384 | 129882 | 68022 | 29376239 |
Parkinsonism | 10.41 | 10.24 | 10 | 130256 | 7268 | 29436993 |
Diaphragm muscle weakness | 10.40 | 10.24 | 7 | 130259 | 138 | 29444123 |
Blood iron decreased | 10.40 | 10.24 | 43 | 130223 | 4405 | 29439856 |
Hyperammonaemia | 10.40 | 10.24 | 6 | 130260 | 5657 | 29438604 |
Blood pressure ambulatory increased | 10.38 | 10.24 | 5 | 130261 | 50 | 29444211 |
Pseudomonas infection | 10.38 | 10.24 | 20 | 130246 | 10832 | 29433429 |
Adjustment disorder | 10.35 | 10.24 | 17 | 130249 | 984 | 29443277 |
Muscle fatigue | 10.35 | 10.24 | 19 | 130247 | 1203 | 29443058 |
Palmar-plantar erythrodysaesthesia syndrome | 10.33 | 10.24 | 32 | 130234 | 14727 | 29429534 |
Venous occlusion | 10.31 | 10.24 | 10 | 130256 | 337 | 29443924 |
Neutrophil count increased | 10.29 | 10.24 | 32 | 130234 | 14710 | 29429551 |
Tendon calcification | 10.29 | 10.24 | 5 | 130261 | 51 | 29444210 |
Myocardial ischaemia | 10.29 | 10.24 | 112 | 130154 | 15916 | 29428345 |
Ventricular hypertrophy | 10.28 | 10.24 | 3 | 130263 | 4261 | 29440000 |
Acute respiratory failure | 10.27 | 10.24 | 71 | 130195 | 26331 | 29417930 |
Tendon disorder | 10.25 | 10.24 | 29 | 130237 | 2449 | 29441812 |
Prostatic specific antigen abnormal | 10.25 | 10.24 | 11 | 130255 | 419 | 29443842 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rhabdomyolysis | 1742.91 | 9.62 | 1892 | 230799 | 89834 | 64176207 |
Myalgia | 1497.85 | 9.62 | 2314 | 230377 | 156303 | 64109738 |
Blood creatine phosphokinase increased | 725.57 | 9.62 | 973 | 231718 | 57585 | 64208456 |
Myopathy | 391.08 | 9.62 | 396 | 232295 | 17284 | 64248757 |
Completed suicide | 347.95 | 9.62 | 188 | 232503 | 224226 | 64041815 |
Sedation complication | 279.98 | 9.62 | 259 | 232432 | 10095 | 64255946 |
Maternal exposure during pregnancy | 266.31 | 9.62 | 21 | 232670 | 95863 | 64170178 |
Creatinine renal clearance decreased | 251.85 | 9.62 | 285 | 232406 | 14136 | 64251905 |
Toxicity to various agents | 248.90 | 9.62 | 593 | 232098 | 362920 | 63903121 |
Drug abuse | 246.18 | 9.62 | 85 | 232606 | 132289 | 64133752 |
Acute kidney injury | 245.50 | 9.62 | 2587 | 230104 | 446653 | 63819388 |
Low density lipoprotein increased | 241.70 | 9.62 | 210 | 232481 | 7530 | 64258511 |
Orthostatic hypotension | 223.33 | 9.62 | 510 | 232181 | 46228 | 64219813 |
High density lipoprotein decreased | 205.81 | 9.62 | 145 | 232546 | 3801 | 64262240 |
Angina pectoris | 199.10 | 9.62 | 477 | 232214 | 44604 | 64221437 |
Blood triglycerides increased | 177.15 | 9.62 | 275 | 232416 | 18591 | 64247450 |
Systemic lupus erythematosus | 166.23 | 9.62 | 38 | 232653 | 77574 | 64188467 |
Death | 165.36 | 9.62 | 1042 | 231649 | 481663 | 63784378 |
Exposure during pregnancy | 162.48 | 9.62 | 40 | 232651 | 77635 | 64188406 |
Pemphigus | 151.21 | 9.62 | 20 | 232671 | 60681 | 64205360 |
Off label use | 150.08 | 9.62 | 1510 | 231181 | 631296 | 63634745 |
Synovitis | 146.29 | 9.62 | 88 | 232603 | 99002 | 64167039 |
Neutropenia | 139.56 | 9.62 | 423 | 232268 | 239201 | 64026840 |
Cognitive disorder | 139.53 | 9.62 | 477 | 232214 | 54610 | 64211431 |
Blood calcium decreased | 135.77 | 9.62 | 291 | 232400 | 25263 | 64240778 |
Balance disorder | 135.36 | 9.62 | 631 | 232060 | 83295 | 64182746 |
Full blood count abnormal | 127.24 | 9.62 | 311 | 232380 | 29446 | 64236595 |
Muscle spasms | 127.07 | 9.62 | 908 | 231783 | 140115 | 64125926 |
Glossodynia | 124.71 | 9.62 | 39 | 232652 | 64657 | 64201384 |
Anti-cyclic citrullinated peptide antibody positive | 124.24 | 9.62 | 16 | 232675 | 49546 | 64216495 |
Low density lipoprotein decreased | 124.09 | 9.62 | 66 | 232625 | 1024 | 64265017 |
Hand deformity | 122.50 | 9.62 | 37 | 232654 | 62734 | 64203307 |
Intentional overdose | 120.48 | 9.62 | 89 | 232602 | 89855 | 64176186 |
Immune-mediated myositis | 116.08 | 9.62 | 88 | 232603 | 2590 | 64263451 |
Blood pressure systolic increased | 114.72 | 9.62 | 416 | 232275 | 49037 | 64217004 |
Blood pressure increased | 110.52 | 9.62 | 1028 | 231663 | 171524 | 64094517 |
Myocardial infarction | 108.77 | 9.62 | 993 | 231698 | 164828 | 64101213 |
Euglycaemic diabetic ketoacidosis | 106.73 | 9.62 | 114 | 232577 | 5296 | 64260745 |
Asthenia | 106.21 | 9.62 | 2149 | 230542 | 425895 | 63840146 |
Infection | 105.02 | 9.62 | 330 | 232361 | 184550 | 64081491 |
Treatment failure | 103.74 | 9.62 | 163 | 232528 | 116653 | 64149388 |
Wound | 103.30 | 9.62 | 75 | 232616 | 76402 | 64189639 |
Diabetic ketoacidosis | 102.12 | 9.62 | 287 | 232404 | 29558 | 64236483 |
Drug ineffective | 100.30 | 9.62 | 2290 | 230401 | 837957 | 63428084 |
Rheumatoid factor negative | 96.54 | 9.62 | 56 | 232635 | 1037 | 64265004 |
Muscular weakness | 96.28 | 9.62 | 787 | 231904 | 126551 | 64139490 |
Dyslipidaemia | 94.24 | 9.62 | 140 | 232551 | 9102 | 64256939 |
Asthma | 88.58 | 9.62 | 618 | 232073 | 94607 | 64171434 |
Blood glucose increased | 88.03 | 9.62 | 631 | 232060 | 97442 | 64168599 |
Contraindicated product administered | 85.21 | 9.62 | 162 | 232529 | 107667 | 64158374 |
Febrile neutropenia | 84.88 | 9.62 | 368 | 232323 | 187289 | 64078752 |
Sedation | 84.76 | 9.62 | 335 | 232356 | 41127 | 64224914 |
Bone erosion | 83.41 | 9.62 | 150 | 232541 | 11445 | 64254596 |
Duodenal ulcer perforation | 82.53 | 9.62 | 13 | 232678 | 34612 | 64231429 |
Cardiac failure | 80.92 | 9.62 | 781 | 231910 | 131592 | 64134449 |
Diabetes mellitus | 79.54 | 9.62 | 460 | 232231 | 66014 | 64200027 |
Pyrexia | 78.73 | 9.62 | 1481 | 231210 | 557163 | 63708878 |
Tendon rupture | 77.08 | 9.62 | 139 | 232552 | 10628 | 64255413 |
Pancytopenia | 77.07 | 9.62 | 262 | 232429 | 143047 | 64122994 |
Therapeutic product effect decreased | 76.51 | 9.62 | 191 | 232500 | 115160 | 64150881 |
Overdose | 76.45 | 9.62 | 306 | 232385 | 159260 | 64106781 |
Chromaturia | 74.98 | 9.62 | 215 | 232476 | 22396 | 64243645 |
Leukopenia | 74.94 | 9.62 | 158 | 232533 | 101084 | 64164957 |
Coronary artery disease | 74.80 | 9.62 | 422 | 232269 | 60011 | 64206030 |
Product use issue | 73.28 | 9.62 | 290 | 232401 | 151425 | 64114616 |
Seizure | 73.22 | 9.62 | 331 | 232360 | 166561 | 64099480 |
Angina unstable | 71.90 | 9.62 | 167 | 232524 | 15300 | 64250741 |
Acute myocardial infarction | 71.75 | 9.62 | 464 | 232227 | 69254 | 64196787 |
Sepsis | 70.29 | 9.62 | 514 | 232177 | 229827 | 64036214 |
Drug resistance | 69.75 | 9.62 | 20 | 232671 | 35082 | 64230959 |
Acute coronary syndrome | 69.33 | 9.62 | 189 | 232502 | 19121 | 64246920 |
Infusion related reaction | 69.30 | 9.62 | 331 | 232360 | 164136 | 64101905 |
Pericarditis | 69.12 | 9.62 | 74 | 232617 | 62442 | 64203599 |
Helicobacter infection | 68.95 | 9.62 | 26 | 232665 | 38336 | 64227705 |
Disease progression | 68.94 | 9.62 | 270 | 232421 | 141410 | 64124631 |
Product use in unapproved indication | 67.32 | 9.62 | 368 | 232323 | 176250 | 64089791 |
Erectile dysfunction | 67.31 | 9.62 | 144 | 232547 | 12483 | 64253558 |
Folliculitis | 65.86 | 9.62 | 14 | 232677 | 30063 | 64235978 |
Coronary artery occlusion | 65.69 | 9.62 | 151 | 232540 | 13740 | 64252301 |
Cardiac failure chronic | 65.08 | 9.62 | 117 | 232574 | 8924 | 64257117 |
General physical health deterioration | 63.89 | 9.62 | 453 | 232238 | 203972 | 64062069 |
Liver disorder | 63.70 | 9.62 | 369 | 232322 | 52982 | 64213059 |
Type 2 diabetes mellitus | 63.30 | 9.62 | 267 | 232424 | 33753 | 64232288 |
Coma | 62.96 | 9.62 | 139 | 232552 | 87476 | 64178565 |
Drug interaction | 61.85 | 9.62 | 1727 | 230964 | 360356 | 63905685 |
Chronic kidney disease | 61.77 | 9.62 | 389 | 232302 | 57530 | 64208511 |
Respiratory arrest | 61.67 | 9.62 | 60 | 232631 | 52925 | 64213116 |
Pancreatitis | 60.90 | 9.62 | 396 | 232295 | 59211 | 64206830 |
Diabetes mellitus inadequate control | 60.58 | 9.62 | 192 | 232499 | 21129 | 64244912 |
Computerised tomogram coronary artery abnormal | 59.92 | 9.62 | 24 | 232667 | 184 | 64265857 |
Pregnancy | 59.55 | 9.62 | 4 | 232687 | 20861 | 64245180 |
Alopecia | 59.48 | 9.62 | 352 | 232339 | 165338 | 64100703 |
Obstructive airways disorder | 58.90 | 9.62 | 201 | 232490 | 22984 | 64243057 |
Bone marrow failure | 58.52 | 9.62 | 52 | 232639 | 47900 | 64218141 |
Sleep disorder due to general medical condition, insomnia type | 57.99 | 9.62 | 12 | 232679 | 26258 | 64239783 |
Impaired healing | 57.95 | 9.62 | 80 | 232611 | 60393 | 64205648 |
Intentional self-injury | 56.88 | 9.62 | 17 | 232674 | 29027 | 64237014 |
Psoriasis | 56.80 | 9.62 | 448 | 232243 | 71255 | 64194786 |
Myositis | 56.52 | 9.62 | 158 | 232533 | 16219 | 64249822 |
Cytomegalovirus infection | 56.35 | 9.62 | 32 | 232659 | 37167 | 64228874 |
Constipation | 56.25 | 9.62 | 1150 | 231541 | 228187 | 64037854 |
Pulmonary function test abnormal | 56.04 | 9.62 | 63 | 232628 | 3101 | 64262940 |
Chest discomfort | 55.49 | 9.62 | 652 | 232039 | 115454 | 64150587 |
Somnolence | 54.88 | 9.62 | 470 | 232221 | 203175 | 64062866 |
Condition aggravated | 53.69 | 9.62 | 983 | 231708 | 371443 | 63894598 |
Reversible airways obstruction | 52.91 | 9.62 | 39 | 232652 | 1099 | 64264942 |
Glycosylated haemoglobin increased | 52.80 | 9.62 | 152 | 232539 | 15867 | 64250174 |
Pain in extremity | 51.83 | 9.62 | 1446 | 231245 | 301639 | 63964402 |
Mucosal inflammation | 51.23 | 9.62 | 92 | 232599 | 62492 | 64203549 |
Arthropathy | 51.21 | 9.62 | 243 | 232448 | 120724 | 64145317 |
Lung diffusion test decreased | 51.18 | 9.62 | 39 | 232652 | 1157 | 64264884 |
Red blood cell sedimentation rate abnormal | 51.14 | 9.62 | 152 | 232539 | 16154 | 64249887 |
Device expulsion | 50.23 | 9.62 | 8 | 232683 | 21128 | 64244913 |
Stomatitis | 50.10 | 9.62 | 214 | 232477 | 109391 | 64156650 |
Thrombocytopenia | 48.74 | 9.62 | 544 | 232147 | 223257 | 64042784 |
Coronary artery stenosis | 48.55 | 9.62 | 118 | 232573 | 11130 | 64254911 |
Mobility decreased | 48.33 | 9.62 | 498 | 232193 | 85342 | 64180699 |
Product substitution issue | 48.17 | 9.62 | 158 | 232533 | 17703 | 64248338 |
5-hydroxyindolacetic acid in urine increased | 47.34 | 9.62 | 21 | 232670 | 213 | 64265828 |
Ischaemic stroke | 47.29 | 9.62 | 219 | 232472 | 28816 | 64237225 |
Abortion spontaneous | 46.96 | 9.62 | 16 | 232675 | 25127 | 64240914 |
Carotid arteriosclerosis | 46.76 | 9.62 | 47 | 232644 | 2032 | 64264009 |
Premature delivery | 46.59 | 9.62 | 6 | 232685 | 18583 | 64247458 |
Interstitial lung disease | 46.33 | 9.62 | 548 | 232143 | 97184 | 64168857 |
Cardio-respiratory arrest | 45.65 | 9.62 | 191 | 232500 | 98202 | 64167839 |
Malignant neoplasm progression | 45.32 | 9.62 | 231 | 232460 | 112640 | 64153401 |
Irritable bowel syndrome | 45.03 | 9.62 | 41 | 232650 | 37328 | 64228713 |
Polymyositis | 44.69 | 9.62 | 52 | 232639 | 2658 | 64263383 |
Haemorrhagic stroke | 44.68 | 9.62 | 106 | 232585 | 9845 | 64256196 |
Orbital myositis | 44.61 | 9.62 | 18 | 232673 | 141 | 64265900 |
Drug-induced liver injury | 44.16 | 9.62 | 309 | 232382 | 47334 | 64218707 |
White blood cell count decreased | 43.99 | 9.62 | 361 | 232330 | 157476 | 64108565 |
Septic shock | 43.93 | 9.62 | 213 | 232478 | 105224 | 64160817 |
Suicide attempt | 43.71 | 9.62 | 122 | 232569 | 70885 | 64195156 |
Cerebral infarction | 43.35 | 9.62 | 275 | 232416 | 40769 | 64225272 |
Restrictive pulmonary disease | 43.26 | 9.62 | 46 | 232645 | 2126 | 64263915 |
Blood mercury abnormal | 43.24 | 9.62 | 19 | 232672 | 188 | 64265853 |
Blood cholesterol increased | 43.11 | 9.62 | 319 | 232372 | 49747 | 64216294 |
Multiple organ dysfunction syndrome | 42.76 | 9.62 | 204 | 232487 | 101209 | 64164832 |
Hepatic function abnormal | 42.55 | 9.62 | 386 | 232305 | 63927 | 64202114 |
Muscle disorder | 42.12 | 9.62 | 69 | 232622 | 4882 | 64261159 |
Fall | 41.43 | 9.62 | 1869 | 230822 | 414957 | 63851084 |
Respiratory failure | 41.21 | 9.62 | 377 | 232314 | 160806 | 64105235 |
Blister | 40.86 | 9.62 | 152 | 232539 | 80815 | 64185226 |
Conjunctivitis allergic | 40.62 | 9.62 | 32 | 232659 | 998 | 64265043 |
Weight decreased | 40.43 | 9.62 | 1332 | 231359 | 284407 | 63981634 |
Chest pain | 40.35 | 9.62 | 1126 | 231565 | 234854 | 64031187 |
Agitation | 40.10 | 9.62 | 173 | 232518 | 88194 | 64177847 |
Ascites | 40.07 | 9.62 | 104 | 232587 | 61897 | 64204144 |
Ulnar tunnel syndrome | 39.90 | 9.62 | 10 | 232681 | 9 | 64266032 |
Lipids abnormal | 39.66 | 9.62 | 24 | 232667 | 482 | 64265559 |
Hepatitis | 39.57 | 9.62 | 291 | 232400 | 45291 | 64220750 |
Needle fatigue | 38.79 | 9.62 | 25 | 232666 | 563 | 64265478 |
Lipoprotein (a) increased | 38.67 | 9.62 | 13 | 232678 | 56 | 64265985 |
Productive cough | 38.54 | 9.62 | 419 | 232272 | 72784 | 64193257 |
Congenital hiatus hernia | 38.28 | 9.62 | 22 | 232669 | 400 | 64265641 |
Vascular stent stenosis | 37.84 | 9.62 | 34 | 232657 | 1275 | 64264766 |
Device related infection | 37.62 | 9.62 | 33 | 232658 | 30593 | 64235448 |
Hyper IgE syndrome | 37.57 | 9.62 | 23 | 232668 | 472 | 64265569 |
Haematuria | 37.52 | 9.62 | 358 | 232333 | 60113 | 64205928 |
Poisoning | 37.41 | 9.62 | 16 | 232675 | 21863 | 64244178 |
Respiratory depression | 37.21 | 9.62 | 19 | 232672 | 23424 | 64242617 |
Haemophagocytic lymphohistiocytosis | 36.95 | 9.62 | 9 | 232682 | 17600 | 64248441 |
Amyotrophic lateral sclerosis | 36.56 | 9.62 | 37 | 232654 | 1613 | 64264428 |
Neutrophil count decreased | 36.34 | 9.62 | 149 | 232542 | 77047 | 64188994 |
Pulmonary valve disease | 35.92 | 9.62 | 18 | 232673 | 245 | 64265796 |
Posterior reversible encephalopathy syndrome | 35.83 | 9.62 | 19 | 232672 | 22927 | 64243114 |
Gait spastic | 35.80 | 9.62 | 28 | 232663 | 864 | 64265177 |
Blood pressure inadequately controlled | 35.39 | 9.62 | 67 | 232624 | 5317 | 64260724 |
Rales | 35.21 | 9.62 | 128 | 232563 | 15101 | 64250940 |
Middle insomnia | 34.80 | 9.62 | 114 | 232577 | 12763 | 64253278 |
Toxic epidermal necrolysis | 34.78 | 9.62 | 50 | 232641 | 37116 | 64228925 |
Hepatocellular injury | 34.38 | 9.62 | 280 | 232411 | 44955 | 64221086 |
Mental status changes | 34.11 | 9.62 | 110 | 232581 | 61052 | 64204989 |
Coronary artery restenosis | 34.10 | 9.62 | 32 | 232659 | 1270 | 64264771 |
Muscle discomfort | 33.91 | 9.62 | 14 | 232677 | 117 | 64265924 |
Hepatojugular reflux | 33.77 | 9.62 | 22 | 232669 | 505 | 64265536 |
Hypoglycaemia | 33.76 | 9.62 | 483 | 232208 | 89409 | 64176632 |
Androgenetic alopecia | 33.74 | 9.62 | 15 | 232676 | 153 | 64265888 |
Lipids increased | 33.66 | 9.62 | 33 | 232658 | 1384 | 64264657 |
Lactic acidosis | 33.49 | 9.62 | 354 | 232337 | 61056 | 64204985 |
Atrial fibrillation | 33.46 | 9.62 | 831 | 231860 | 170258 | 64095783 |
Supine hypertension | 33.23 | 9.62 | 19 | 232672 | 342 | 64265699 |
Generalised tonic-clonic seizure | 33.15 | 9.62 | 58 | 232633 | 39799 | 64226242 |
Neurotoxicity | 33.10 | 9.62 | 30 | 232661 | 27374 | 64238667 |
Drug dependence | 33.00 | 9.62 | 43 | 232648 | 33269 | 64232772 |
Diastolic dysfunction | 33.00 | 9.62 | 88 | 232603 | 8787 | 64257254 |
Blood creatinine increased | 32.96 | 9.62 | 680 | 232011 | 135102 | 64130939 |
Arterial occlusive disease | 32.75 | 9.62 | 76 | 232615 | 6957 | 64259084 |
Eosinophilia | 32.43 | 9.62 | 242 | 232449 | 37834 | 64228207 |
Transient ischaemic attack | 32.25 | 9.62 | 271 | 232420 | 43911 | 64222130 |
Thrombotic microangiopathy | 32.16 | 9.62 | 10 | 232681 | 16645 | 64249396 |
Encephalopathy | 31.96 | 9.62 | 107 | 232584 | 58712 | 64207329 |
Cough | 31.34 | 9.62 | 1361 | 231330 | 300787 | 63965254 |
Neutropenic sepsis | 31.19 | 9.62 | 23 | 232668 | 23249 | 64242792 |
Serotonin syndrome | 31.03 | 9.62 | 59 | 232632 | 39223 | 64226818 |
Electrocardiogram Q wave abnormal | 30.99 | 9.62 | 19 | 232672 | 391 | 64265650 |
Hypertonic bladder | 30.94 | 9.62 | 49 | 232642 | 3369 | 64262672 |
Left ventricular enlargement | 30.81 | 9.62 | 23 | 232668 | 661 | 64265380 |
Muscle atrophy | 30.63 | 9.62 | 91 | 232600 | 9667 | 64256374 |
Drug withdrawal syndrome | 30.37 | 9.62 | 41 | 232650 | 31250 | 64234791 |
Pancreatitis acute | 30.30 | 9.62 | 261 | 232430 | 42594 | 64223447 |
Exercise tolerance decreased | 30.25 | 9.62 | 78 | 232613 | 7632 | 64258409 |
Vomiting | 30.25 | 9.62 | 1653 | 231038 | 549464 | 63716577 |
Renal failure | 30.22 | 9.62 | 864 | 231827 | 180824 | 64085217 |
Albuminuria | 29.54 | 9.62 | 22 | 232669 | 630 | 64265411 |
Necrotising myositis | 29.42 | 9.62 | 25 | 232666 | 869 | 64265172 |
Vital capacity decreased | 29.34 | 9.62 | 27 | 232664 | 1045 | 64264996 |
Pathogen resistance | 29.24 | 9.62 | 5 | 232686 | 12538 | 64253503 |
Blood creatine phosphokinase | 29.20 | 9.62 | 12 | 232679 | 99 | 64265942 |
Rhinitis perennial | 29.07 | 9.62 | 15 | 232676 | 218 | 64265823 |
Swelling | 29.02 | 9.62 | 405 | 232286 | 159813 | 64106228 |
Dizziness | 28.95 | 9.62 | 1860 | 230831 | 428303 | 63837738 |
Nipple inflammation | 28.55 | 9.62 | 10 | 232681 | 50 | 64265991 |
Hypotension | 28.36 | 9.62 | 1662 | 231029 | 379312 | 63886729 |
Cataract | 28.19 | 9.62 | 296 | 232395 | 50966 | 64215075 |
Akathisia | 28.17 | 9.62 | 4 | 232687 | 11506 | 64254535 |
Injection site reaction | 28.11 | 9.62 | 81 | 232610 | 46583 | 64219458 |
Therapy non-responder | 28.10 | 9.62 | 132 | 232559 | 65767 | 64200274 |
Carotid artery stenosis | 27.78 | 9.62 | 77 | 232614 | 7864 | 64258177 |
Transplant rejection | 27.78 | 9.62 | 14 | 232677 | 17387 | 64248654 |
Cerebral haemorrhage | 27.62 | 9.62 | 294 | 232397 | 50796 | 64215245 |
Arteriosclerosis | 27.53 | 9.62 | 122 | 232569 | 15755 | 64250286 |
Vascular stent thrombosis | 27.43 | 9.62 | 46 | 232645 | 3318 | 64262723 |
Muscle injury | 27.36 | 9.62 | 33 | 232658 | 26404 | 64239637 |
Hypercholesterolaemia | 27.32 | 9.62 | 119 | 232572 | 15254 | 64250787 |
Troponin increased | 27.21 | 9.62 | 119 | 232572 | 15280 | 64250761 |
Gynaecomastia | 26.92 | 9.62 | 64 | 232627 | 5952 | 64260089 |
Rash | 26.90 | 9.62 | 1366 | 231325 | 457183 | 63808858 |
Goitre | 26.83 | 9.62 | 57 | 232634 | 4916 | 64261125 |
Candida infection | 26.79 | 9.62 | 45 | 232646 | 31374 | 64234667 |
Hemiplegia | 26.77 | 9.62 | 104 | 232587 | 12664 | 64253377 |
Sinusitis | 26.74 | 9.62 | 368 | 232323 | 145560 | 64120481 |
Bronchopulmonary aspergillosis | 26.71 | 9.62 | 18 | 232673 | 19067 | 64246974 |
Injection site erythema | 26.68 | 9.62 | 148 | 232543 | 70652 | 64195389 |
Arteriosclerosis coronary artery | 26.68 | 9.62 | 119 | 232572 | 15410 | 64250631 |
Muscle rupture | 26.42 | 9.62 | 44 | 232647 | 3156 | 64262885 |
Neoplasm progression | 26.24 | 9.62 | 69 | 232622 | 40895 | 64225146 |
Gait disturbance | 26.01 | 9.62 | 809 | 231882 | 171346 | 64094695 |
Injection site pain | 25.76 | 9.62 | 267 | 232424 | 111141 | 64154900 |
Stent placement | 25.72 | 9.62 | 60 | 232631 | 5511 | 64260530 |
Low cardiac output syndrome | 25.69 | 9.62 | 22 | 232669 | 773 | 64265268 |
Eosinophil count increased | 25.66 | 9.62 | 110 | 232581 | 14002 | 64252039 |
Hepatic encephalopathy | 25.52 | 9.62 | 23 | 232668 | 21043 | 64244998 |
Myelosuppression | 25.46 | 9.62 | 29 | 232662 | 23801 | 64242240 |
Total bile acids increased | 25.38 | 9.62 | 10 | 232681 | 73 | 64265968 |
Pneumonia | 25.29 | 9.62 | 1709 | 230982 | 557867 | 63708174 |
Caesarean section | 25.20 | 9.62 | 5 | 232686 | 11269 | 64254772 |
Injury | 25.16 | 9.62 | 110 | 232581 | 55882 | 64210159 |
Pericardial disease | 25.08 | 9.62 | 18 | 232673 | 486 | 64265555 |
Aspergillus infection | 24.93 | 9.62 | 14 | 232677 | 16365 | 64249676 |
Relapsing-remitting multiple sclerosis | 24.83 | 9.62 | 25 | 232666 | 1083 | 64264958 |
Lipase increased | 24.47 | 9.62 | 110 | 232581 | 14292 | 64251749 |
Mitral valve incompetence | 24.47 | 9.62 | 167 | 232524 | 25371 | 64240670 |
Haematotoxicity | 24.44 | 9.62 | 8 | 232683 | 12888 | 64253153 |
Chronic obstructive pulmonary disease | 24.42 | 9.62 | 376 | 232315 | 70672 | 64195369 |
Hospitalisation | 24.28 | 9.62 | 165 | 232526 | 75042 | 64190999 |
Burning sensation | 24.20 | 9.62 | 280 | 232411 | 49384 | 64216657 |
Pneumocystis jirovecii pneumonia | 24.10 | 9.62 | 39 | 232652 | 27595 | 64238446 |
Amblyopia | 23.92 | 9.62 | 13 | 232678 | 211 | 64265830 |
Dermatitis allergic | 23.90 | 9.62 | 113 | 232578 | 14996 | 64251045 |
Pollakiuria | 23.87 | 9.62 | 195 | 232496 | 31335 | 64234706 |
Cytomegalovirus viraemia | 23.79 | 9.62 | 5 | 232686 | 10823 | 64255218 |
Eczema | 23.69 | 9.62 | 186 | 232505 | 29534 | 64236507 |
Tachycardia | 23.69 | 9.62 | 388 | 232303 | 149191 | 64116850 |
Blood cholesterol abnormal | 23.67 | 9.62 | 38 | 232653 | 2643 | 64263398 |
Skin laceration | 23.59 | 9.62 | 160 | 232531 | 24257 | 64241784 |
Dystonia | 23.57 | 9.62 | 20 | 232671 | 18845 | 64247196 |
Creutzfeldt-Jakob disease | 23.52 | 9.62 | 12 | 232679 | 170 | 64265871 |
Mite allergy | 23.35 | 9.62 | 20 | 232671 | 703 | 64265338 |
Growth hormone deficiency | 23.35 | 9.62 | 15 | 232676 | 336 | 64265705 |
Substance abuse | 23.28 | 9.62 | 3 | 232688 | 9289 | 64256752 |
Aortic aneurysm | 23.18 | 9.62 | 70 | 232621 | 7504 | 64258537 |
Crush syndrome | 23.04 | 9.62 | 12 | 232679 | 178 | 64265863 |
Neuroleptic malignant syndrome | 23.02 | 9.62 | 34 | 232657 | 24962 | 64241079 |
Spirometry abnormal | 22.94 | 9.62 | 18 | 232673 | 558 | 64265483 |
Immunodeficiency | 22.84 | 9.62 | 15 | 232676 | 16109 | 64249932 |
Poisoning deliberate | 22.76 | 9.62 | 10 | 232681 | 13448 | 64252593 |
Peripheral arterial occlusive disease | 22.74 | 9.62 | 66 | 232625 | 6921 | 64259120 |
Photosensitivity reaction | 22.54 | 9.62 | 127 | 232564 | 18046 | 64247995 |
Aggression | 22.54 | 9.62 | 88 | 232603 | 46144 | 64219897 |
Blood glucose abnormal | 22.40 | 9.62 | 77 | 232614 | 8836 | 64257205 |
N-terminal prohormone brain natriuretic peptide abnormal | 22.40 | 9.62 | 13 | 232678 | 241 | 64265800 |
Hepatic neoplasm | 22.38 | 9.62 | 40 | 232651 | 3037 | 64263004 |
Plasmapheresis | 22.29 | 9.62 | 18 | 232673 | 582 | 64265459 |
Physical examination abnormal | 22.26 | 9.62 | 13 | 232678 | 244 | 64265797 |
Stenosis | 22.21 | 9.62 | 30 | 232661 | 1785 | 64264256 |
Unresponsive to stimuli | 22.04 | 9.62 | 100 | 232591 | 50293 | 64215748 |
Cardiac arrest | 22.03 | 9.62 | 407 | 232284 | 153657 | 64112384 |
Mydriasis | 22.03 | 9.62 | 14 | 232677 | 15298 | 64250743 |
Abnormal behaviour | 22.03 | 9.62 | 56 | 232635 | 33566 | 64232475 |
Transaminases increased | 21.99 | 9.62 | 252 | 232439 | 44342 | 64221699 |
Malignant mediastinal neoplasm | 21.95 | 9.62 | 17 | 232674 | 517 | 64265524 |
Nephritic syndrome | 21.84 | 9.62 | 13 | 232678 | 253 | 64265788 |
Hyperkalaemia | 21.83 | 9.62 | 498 | 232193 | 100631 | 64165410 |
Bronchiectasis | 21.82 | 9.62 | 105 | 232586 | 14035 | 64252006 |
Hip arthroplasty | 21.73 | 9.62 | 27 | 232664 | 21324 | 64244717 |
Acute hepatic failure | 21.71 | 9.62 | 38 | 232653 | 26074 | 64239967 |
Aspartate aminotransferase increased | 21.70 | 9.62 | 576 | 232115 | 119212 | 64146829 |
Adjustment disorder | 21.67 | 9.62 | 37 | 232654 | 2708 | 64263333 |
Ventricular hyperkinesia | 21.53 | 9.62 | 13 | 232678 | 260 | 64265781 |
Depressed level of consciousness | 21.48 | 9.62 | 413 | 232278 | 81023 | 64185018 |
Status epilepticus | 21.42 | 9.62 | 28 | 232663 | 21635 | 64244406 |
Sopor | 21.35 | 9.62 | 47 | 232644 | 29614 | 64236427 |
Haemorrhage subcutaneous | 21.28 | 9.62 | 48 | 232643 | 4313 | 64261728 |
Musculoskeletal toxicity | 21.25 | 9.62 | 11 | 232680 | 161 | 64265880 |
Left ventricular hypertrophy | 21.22 | 9.62 | 79 | 232612 | 9427 | 64256614 |
Tricuspid valve incompetence | 21.21 | 9.62 | 119 | 232572 | 16884 | 64249157 |
Inspiratory capacity abnormal | 21.13 | 9.62 | 9 | 232682 | 82 | 64265959 |
Mycobacterium test positive | 21.10 | 9.62 | 15 | 232676 | 399 | 64265642 |
Myocardial ischaemia | 21.08 | 9.62 | 150 | 232541 | 23101 | 64242940 |
Carotid artery thrombosis | 20.95 | 9.62 | 29 | 232662 | 1766 | 64264275 |
Blood pressure systolic abnormal | 20.86 | 9.62 | 81 | 232610 | 9861 | 64256180 |
Gangrene | 20.77 | 9.62 | 66 | 232625 | 7272 | 64258769 |
Skin necrosis | 20.75 | 9.62 | 13 | 232678 | 14316 | 64251725 |
Blood test abnormal | 20.62 | 9.62 | 97 | 232594 | 12846 | 64253195 |
Aortic stenosis | 20.59 | 9.62 | 60 | 232631 | 6305 | 64259736 |
Prostatic specific antigen increased | 20.57 | 9.62 | 74 | 232617 | 8686 | 64257355 |
Helicobacter gastritis | 20.55 | 9.62 | 32 | 232659 | 2168 | 64263873 |
Body temperature decreased | 20.52 | 9.62 | 162 | 232529 | 25766 | 64240275 |
Bundle branch block left | 20.44 | 9.62 | 81 | 232610 | 9953 | 64256088 |
Acute respiratory distress syndrome | 20.36 | 9.62 | 72 | 232619 | 38863 | 64227178 |
Myoglobin blood increased | 20.35 | 9.62 | 36 | 232655 | 2711 | 64263330 |
Paraplegia | 20.34 | 9.62 | 48 | 232643 | 4442 | 64261599 |
Autoimmune hepatitis | 20.22 | 9.62 | 81 | 232610 | 10003 | 64256038 |
Blood cholesterol decreased | 20.19 | 9.62 | 26 | 232665 | 1476 | 64264565 |
Brain natriuretic peptide abnormal | 20.10 | 9.62 | 18 | 232673 | 672 | 64265369 |
Hypertension | 20.03 | 9.62 | 1135 | 231556 | 258126 | 64007915 |
Forced vital capacity decreased | 20.00 | 9.62 | 26 | 232665 | 1490 | 64264551 |
Mean platelet volume increased | 19.99 | 9.62 | 21 | 232670 | 957 | 64265084 |
Hyperthyroidism | 19.94 | 9.62 | 123 | 232568 | 18056 | 64247985 |
Oropharyngeal discomfort | 19.94 | 9.62 | 53 | 232638 | 5282 | 64260759 |
Confabulation | 19.71 | 9.62 | 15 | 232676 | 444 | 64265597 |
Withdrawal syndrome | 19.70 | 9.62 | 34 | 232657 | 23458 | 64242583 |
Cystitis | 19.64 | 9.62 | 238 | 232453 | 42437 | 64223604 |
Ulcer | 19.53 | 9.62 | 33 | 232658 | 22957 | 64243084 |
Blood pressure diastolic abnormal | 19.49 | 9.62 | 90 | 232601 | 11827 | 64254214 |
Aortic valve incompetence | 19.39 | 9.62 | 70 | 232621 | 8231 | 64257810 |
Drug intolerance | 19.35 | 9.62 | 523 | 232168 | 187469 | 64078572 |
Mitral valve thickening | 19.22 | 9.62 | 14 | 232677 | 387 | 64265654 |
Blood pressure fluctuation | 19.18 | 9.62 | 278 | 232413 | 51593 | 64214448 |
Lipoma | 19.18 | 9.62 | 34 | 232657 | 2565 | 64263476 |
Right atrial enlargement | 19.09 | 9.62 | 13 | 232678 | 322 | 64265719 |
Rheumatic fever | 19.02 | 9.62 | 5 | 232686 | 9289 | 64256752 |
Suspected suicide | 19.00 | 9.62 | 4 | 232687 | 8650 | 64257391 |
Pulmonary embolism | 18.99 | 9.62 | 393 | 232298 | 145963 | 64120078 |
Pruritus | 18.89 | 9.62 | 1339 | 231352 | 311061 | 63954980 |
Intermittent claudication | 18.84 | 9.62 | 37 | 232654 | 3017 | 64263024 |
Adverse drug reaction | 18.84 | 9.62 | 92 | 232599 | 45372 | 64220669 |
Dyspnoea exertional | 18.79 | 9.62 | 372 | 232319 | 73358 | 64192683 |
Haemoglobin increased | 18.76 | 9.62 | 51 | 232640 | 5150 | 64260891 |
Confusional state | 18.72 | 9.62 | 761 | 231930 | 260383 | 64005658 |
Dry mouth | 18.61 | 9.62 | 314 | 232377 | 60104 | 64205937 |
Acute myeloid leukaemia | 18.57 | 9.62 | 45 | 232646 | 27418 | 64238623 |
Sinus congestion | 18.56 | 9.62 | 107 | 232584 | 15332 | 64250709 |
Dermatomyositis | 18.54 | 9.62 | 35 | 232656 | 2771 | 64263270 |
Immune reconstitution inflammatory syndrome | 18.50 | 9.62 | 11 | 232680 | 12459 | 64253582 |
Very low density lipoprotein increased | 18.47 | 9.62 | 10 | 232681 | 161 | 64265880 |
Fractured coccyx | 18.43 | 9.62 | 20 | 232671 | 946 | 64265095 |
Drug-disease interaction | 18.40 | 9.62 | 18 | 232673 | 753 | 64265288 |
Procollagen type I C-terminal propeptide increased | 18.20 | 9.62 | 6 | 232685 | 24 | 64266017 |
Enterococcal infection | 18.20 | 9.62 | 14 | 232677 | 13852 | 64252189 |
Tenosynovitis | 18.18 | 9.62 | 10 | 232681 | 11823 | 64254218 |
Glomerular filtration rate decreased | 18.17 | 9.62 | 127 | 232564 | 19445 | 64246596 |
Injection site swelling | 18.12 | 9.62 | 82 | 232609 | 41271 | 64224770 |
Alanine aminotransferase increased | 18.08 | 9.62 | 642 | 232049 | 138389 | 64127652 |
Cerebrovascular accident | 18.07 | 9.62 | 636 | 232055 | 136947 | 64129094 |
Drug ineffective for unapproved indication | 18.06 | 9.62 | 55 | 232636 | 31078 | 64234963 |
Skin haemorrhage | 18.05 | 9.62 | 70 | 232621 | 8515 | 64257526 |
Retro-orbital neoplasm | 18.02 | 9.62 | 7 | 232684 | 49 | 64265992 |
Sensorimotor disorder | 17.97 | 9.62 | 18 | 232673 | 775 | 64265266 |
Device issue | 17.90 | 9.62 | 34 | 232657 | 22614 | 64243427 |
Nipple disorder | 17.89 | 9.62 | 10 | 232681 | 172 | 64265869 |
Infusion site streaking | 17.87 | 9.62 | 14 | 232677 | 433 | 64265608 |
Anaemia | 17.84 | 9.62 | 1152 | 231539 | 377528 | 63888513 |
Malignant melanoma in situ | 17.74 | 9.62 | 27 | 232664 | 1793 | 64264248 |
Angiocardiogram | 17.70 | 9.62 | 11 | 232680 | 232 | 64265809 |
Cytokine release syndrome | 17.60 | 9.62 | 30 | 232661 | 20799 | 64245242 |
Cholestasis | 17.60 | 9.62 | 243 | 232448 | 44629 | 64221412 |
Bacterial infection | 17.58 | 9.62 | 40 | 232651 | 24910 | 64241131 |
Arthralgia | 17.54 | 9.62 | 1837 | 230854 | 440423 | 63825618 |
Myasthenia gravis | 17.53 | 9.62 | 53 | 232638 | 5685 | 64260356 |
Guillain-Barre syndrome | 17.50 | 9.62 | 64 | 232627 | 7571 | 64258470 |
Bacteraemia | 17.49 | 9.62 | 45 | 232646 | 26866 | 64239175 |
Serum procollagen type I N-terminal propeptide increased | 17.46 | 9.62 | 6 | 232685 | 28 | 64266013 |
Pertussis | 17.44 | 9.62 | 18 | 232673 | 803 | 64265238 |
Hepatitis C | 17.38 | 9.62 | 9 | 232682 | 11006 | 64255035 |
Tumour lysis syndrome | 17.36 | 9.62 | 27 | 232664 | 19413 | 64246628 |
Hypersensitivity | 17.35 | 9.62 | 558 | 232133 | 195894 | 64070147 |
Hyperlipidaemia | 17.34 | 9.62 | 142 | 232549 | 22834 | 64243207 |
Bladder cancer | 17.30 | 9.62 | 82 | 232609 | 10892 | 64255149 |
Intentional product use issue | 17.28 | 9.62 | 241 | 232450 | 95123 | 64170918 |
Neurologic neglect syndrome | 17.20 | 9.62 | 25 | 232666 | 1593 | 64264448 |
Aplastic anaemia | 17.10 | 9.62 | 15 | 232676 | 13905 | 64252136 |
Malignant melanoma | 17.02 | 9.62 | 92 | 232599 | 12872 | 64253169 |
Mucormycosis | 16.95 | 9.62 | 3 | 232688 | 7338 | 64258703 |
Occult blood | 16.89 | 9.62 | 23 | 232668 | 1379 | 64264662 |
Ligament pain | 16.87 | 9.62 | 10 | 232681 | 193 | 64265848 |
Hypereosinophilic syndrome | 16.76 | 9.62 | 14 | 232677 | 475 | 64265566 |
Decreased ventricular preload | 16.66 | 9.62 | 6 | 232685 | 33 | 64266008 |
Miosis | 16.65 | 9.62 | 14 | 232677 | 13252 | 64252789 |
Polymyalgia rheumatica | 16.42 | 9.62 | 37 | 232654 | 3322 | 64262719 |
Syncope | 16.30 | 9.62 | 710 | 231981 | 156925 | 64109116 |
Meningitis eosinophilic | 16.26 | 9.62 | 5 | 232686 | 15 | 64266026 |
Pulmonary haemorrhage | 16.25 | 9.62 | 14 | 232677 | 13095 | 64252946 |
Transcription medication error | 16.25 | 9.62 | 12 | 232679 | 339 | 64265702 |
Cardiovascular somatic symptom disorder | 16.22 | 9.62 | 6 | 232685 | 36 | 64266005 |
Mycotic allergy | 16.21 | 9.62 | 19 | 232672 | 979 | 64265062 |
Platelet count decreased | 16.13 | 9.62 | 471 | 232220 | 167240 | 64098801 |
Unwanted awareness during anaesthesia | 16.10 | 9.62 | 11 | 232680 | 274 | 64265767 |
Coagulopathy | 16.05 | 9.62 | 60 | 232631 | 31860 | 64234181 |
Ileus | 16.03 | 9.62 | 37 | 232654 | 22929 | 64243112 |
Suicidal ideation | 15.99 | 9.62 | 158 | 232533 | 66384 | 64199657 |
Total cholesterol/HDL ratio increased | 15.92 | 9.62 | 10 | 232681 | 215 | 64265826 |
Blood uric acid increased | 15.91 | 9.62 | 65 | 232626 | 8098 | 64257943 |
Melanoderma | 15.86 | 9.62 | 12 | 232679 | 352 | 64265689 |
Degenerative aortic valve disease | 15.83 | 9.62 | 8 | 232683 | 111 | 64265930 |
AST/ALT ratio abnormal | 15.80 | 9.62 | 5 | 232686 | 17 | 64266024 |
High density lipoprotein increased | 15.74 | 9.62 | 19 | 232672 | 1010 | 64265031 |
Carcinoid tumour | 15.72 | 9.62 | 13 | 232678 | 435 | 64265606 |
Prinzmetal angina | 15.66 | 9.62 | 23 | 232668 | 1480 | 64264561 |
Colitis ulcerative | 15.63 | 9.62 | 139 | 232552 | 22889 | 64243152 |
Hypocholesterolaemia | 15.59 | 9.62 | 9 | 232682 | 165 | 64265876 |
Diabetic metabolic decompensation | 15.57 | 9.62 | 32 | 232659 | 2696 | 64263345 |
Lethargy | 15.56 | 9.62 | 177 | 232514 | 72417 | 64193624 |
Lichenoid keratosis | 15.50 | 9.62 | 36 | 232655 | 3298 | 64262743 |
Mesenteric artery thrombosis | 15.45 | 9.62 | 14 | 232677 | 531 | 64265510 |
Presyncope | 15.42 | 9.62 | 194 | 232497 | 34895 | 64231146 |
Lichen planus | 15.34 | 9.62 | 29 | 232662 | 2299 | 64263742 |
Hyperkeratosis | 15.31 | 9.62 | 56 | 232635 | 6625 | 64259416 |
Blood thyroid stimulating hormone abnormal | 15.21 | 9.62 | 16 | 232675 | 730 | 64265311 |
Hepatic steatosis | 15.19 | 9.62 | 175 | 232516 | 30832 | 64235209 |
Osteonecrosis of jaw | 15.14 | 9.62 | 83 | 232608 | 39742 | 64226299 |
Oxygen consumption decreased | 15.13 | 9.62 | 12 | 232679 | 378 | 64265663 |
Rheumatoid nodule | 15.10 | 9.62 | 14 | 232677 | 12637 | 64253404 |
Product residue present | 15.06 | 9.62 | 35 | 232656 | 3207 | 64262834 |
Myopathy toxic | 15.00 | 9.62 | 17 | 232674 | 844 | 64265197 |
Cystitis haemorrhagic | 14.97 | 9.62 | 5 | 232686 | 7951 | 64258090 |
Nodular rash | 14.95 | 9.62 | 11 | 232680 | 309 | 64265732 |
Nephrolithiasis | 14.94 | 9.62 | 231 | 232460 | 43452 | 64222589 |
Encephalitis | 14.90 | 9.62 | 14 | 232677 | 12557 | 64253484 |
Cardiac discomfort | 14.88 | 9.62 | 19 | 232672 | 1070 | 64264971 |
Head discomfort | 14.88 | 9.62 | 83 | 232608 | 11751 | 64254290 |
Injection site bruising | 14.84 | 9.62 | 74 | 232617 | 36299 | 64229742 |
Histamine level increased | 14.82 | 9.62 | 7 | 232684 | 83 | 64265958 |
Lymphomatoid papulosis | 14.77 | 9.62 | 11 | 232680 | 315 | 64265726 |
Oedema peripheral | 14.76 | 9.62 | 913 | 231778 | 209404 | 64056637 |
Pancreatic neuroendocrine tumour | 14.75 | 9.62 | 13 | 232678 | 475 | 64265566 |
Progressive multifocal leukoencephalopathy | 14.74 | 9.62 | 27 | 232664 | 18205 | 64247836 |
Hyperglycaemia | 14.67 | 9.62 | 305 | 232386 | 60663 | 64205378 |
Right ventricular failure | 14.66 | 9.62 | 35 | 232656 | 21436 | 64244605 |
Hypercreatinaemia | 14.64 | 9.62 | 10 | 232681 | 249 | 64265792 |
Gastrooesophageal reflux disease | 14.54 | 9.62 | 398 | 232293 | 82745 | 64183296 |
Apolipoprotein A-I decreased | 14.44 | 9.62 | 5 | 232686 | 24 | 64266017 |
Respiratory distress | 14.42 | 9.62 | 120 | 232571 | 52211 | 64213830 |
Oxygen saturation increased | 14.41 | 9.62 | 13 | 232678 | 490 | 64265551 |
Granulocytopenia | 14.41 | 9.62 | 10 | 232681 | 10430 | 64255611 |
Fibromyalgia | 14.40 | 9.62 | 73 | 232618 | 35658 | 64230383 |
Ureteric cancer | 14.40 | 9.62 | 10 | 232681 | 256 | 64265785 |
Panniculitis | 14.39 | 9.62 | 7 | 232684 | 8872 | 64257169 |
Deep vein thrombosis | 14.37 | 9.62 | 280 | 232411 | 104902 | 64161139 |
Atrial thrombosis | 14.31 | 9.62 | 33 | 232658 | 3009 | 64263032 |
Food aversion | 14.29 | 9.62 | 15 | 232676 | 683 | 64265358 |
Amylase increased | 14.29 | 9.62 | 71 | 232620 | 9614 | 64256427 |
Brain oedema | 14.28 | 9.62 | 37 | 232654 | 22038 | 64244003 |
Metastases to bone | 14.20 | 9.62 | 33 | 232658 | 20402 | 64245639 |
Prostatic haemorrhage | 14.14 | 9.62 | 8 | 232683 | 141 | 64265900 |
Lower respiratory tract infection | 14.13 | 9.62 | 248 | 232443 | 94366 | 64171675 |
Neurotrophic keratopathy | 13.89 | 9.62 | 3 | 232688 | 0 | 64266041 |
Pancreatic carcinoma | 13.88 | 9.62 | 74 | 232617 | 10299 | 64255742 |
Lung neoplasm malignant | 13.81 | 9.62 | 128 | 232563 | 21320 | 64244721 |
Dust allergy | 13.80 | 9.62 | 18 | 232673 | 1035 | 64265006 |
Gastrointestinal disorder | 13.77 | 9.62 | 234 | 232457 | 89475 | 64176566 |
Mental disorder | 13.76 | 9.62 | 49 | 232642 | 26396 | 64239645 |
Palpitations | 13.71 | 9.62 | 483 | 232208 | 104005 | 64162036 |
Ventricular hypokinesia | 13.70 | 9.62 | 60 | 232631 | 7709 | 64258332 |
Body temperature increased | 13.62 | 9.62 | 77 | 232614 | 36589 | 64229452 |
Medication error | 13.58 | 9.62 | 115 | 232576 | 49851 | 64216190 |
Base excess decreased | 13.56 | 9.62 | 11 | 232680 | 358 | 64265683 |
Haemorrhagic cerebral infarction | 13.53 | 9.62 | 20 | 232671 | 1294 | 64264747 |
Arterial spasm | 13.52 | 9.62 | 8 | 232683 | 154 | 64265887 |
No adverse event | 13.52 | 9.62 | 55 | 232636 | 28506 | 64237535 |
Plasma cell myeloma | 13.46 | 9.62 | 104 | 232587 | 45971 | 64220070 |
Dyspepsia | 13.36 | 9.62 | 382 | 232309 | 79930 | 64186111 |
Electrocardiogram QRS complex abnormal | 13.34 | 9.62 | 13 | 232678 | 541 | 64265500 |
Cytopenia | 13.34 | 9.62 | 22 | 232669 | 15449 | 64250592 |
Total lung capacity decreased | 13.32 | 9.62 | 23 | 232668 | 1699 | 64264342 |
Mania | 13.27 | 9.62 | 24 | 232667 | 16262 | 64249779 |
Kidney transplant rejection | 13.27 | 9.62 | 9 | 232682 | 9502 | 64256539 |
Electrocardiogram ambulatory abnormal | 13.27 | 9.62 | 4 | 232687 | 11 | 64266030 |
Clitoris abscess | 13.27 | 9.62 | 4 | 232687 | 11 | 64266030 |
Epilepsy | 13.24 | 9.62 | 69 | 232622 | 33462 | 64232579 |
Exposure to toxic agent | 13.21 | 9.62 | 3 | 232688 | 6156 | 64259885 |
Sinus pain | 13.20 | 9.62 | 29 | 232662 | 2560 | 64263481 |
Essential hypertension | 13.16 | 9.62 | 45 | 232646 | 5149 | 64260892 |
Renal cyst | 13.13 | 9.62 | 84 | 232607 | 12486 | 64253555 |
Paradoxical drug reaction | 13.09 | 9.62 | 3 | 232688 | 6117 | 64259924 |
Supraventricular extrasystoles | 13.07 | 9.62 | 49 | 232642 | 5866 | 64260175 |
Lymphopenia | 13.05 | 9.62 | 48 | 232643 | 25609 | 64240432 |
Thalamus haemorrhage | 13.02 | 9.62 | 22 | 232669 | 1597 | 64264444 |
Anaphylactic reaction | 12.99 | 9.62 | 172 | 232519 | 68492 | 64197549 |
Electrolyte imbalance | 12.98 | 9.62 | 47 | 232644 | 25196 | 64240845 |
Psychomotor hyperactivity | 12.98 | 9.62 | 20 | 232671 | 14431 | 64251610 |
Cyanosis | 12.95 | 9.62 | 39 | 232652 | 22116 | 64243925 |
Aldolase increased | 12.94 | 9.62 | 9 | 232682 | 231 | 64265810 |
Multiple sclerosis relapse | 12.90 | 9.62 | 91 | 232600 | 41044 | 64224997 |
Diabetic neuropathy | 12.88 | 9.62 | 47 | 232644 | 5554 | 64260487 |
Ketoacidosis | 12.87 | 9.62 | 54 | 232637 | 6809 | 64259232 |
Infrequent bowel movements | 12.85 | 9.62 | 20 | 232671 | 1355 | 64264686 |
Eye haemorrhage | 12.84 | 9.62 | 62 | 232629 | 8298 | 64257743 |
Blood loss anaemia | 12.81 | 9.62 | 90 | 232601 | 13802 | 64252239 |
Wheezing | 12.78 | 9.62 | 381 | 232310 | 80198 | 64185843 |
Blood triglycerides decreased | 12.74 | 9.62 | 8 | 232683 | 172 | 64265869 |
Discomfort | 12.73 | 9.62 | 210 | 232481 | 80668 | 64185373 |
Hepatic failure | 12.70 | 9.62 | 133 | 232558 | 55261 | 64210780 |
Escherichia infection | 12.68 | 9.62 | 22 | 232669 | 15146 | 64250895 |
Myotonic dystrophy | 12.64 | 9.62 | 6 | 232685 | 72 | 64265969 |
Thrombosis | 12.63 | 9.62 | 179 | 232512 | 70463 | 64195578 |
Listless | 12.62 | 9.62 | 33 | 232658 | 3257 | 64262784 |
Micturition urgency | 12.59 | 9.62 | 72 | 232619 | 10287 | 64255754 |
Hyperreflexia | 12.59 | 9.62 | 5 | 232686 | 7143 | 64258898 |
Left atrial enlargement | 12.54 | 9.62 | 17 | 232674 | 1015 | 64265026 |
Tendonitis | 12.54 | 9.62 | 120 | 232571 | 20162 | 64245879 |
Clostridium difficile colitis | 12.52 | 9.62 | 53 | 232638 | 27170 | 64238871 |
Myelodysplastic syndrome | 12.50 | 9.62 | 54 | 232637 | 27525 | 64238516 |
Sneezing | 12.46 | 9.62 | 96 | 232595 | 15155 | 64250886 |
Muscle rigidity | 12.32 | 9.62 | 28 | 232663 | 17445 | 64248596 |
Blood creatine phosphokinase MM increased | 12.30 | 9.62 | 5 | 232686 | 40 | 64266001 |
Skin test negative | 12.30 | 9.62 | 5 | 232686 | 40 | 64266001 |
Klebsiella infection | 12.29 | 9.62 | 18 | 232673 | 13263 | 64252778 |
Tendon pain | 12.29 | 9.62 | 42 | 232649 | 4806 | 64261235 |
Sinonasal obstruction | 12.23 | 9.62 | 8 | 232683 | 185 | 64265856 |
Injection site pruritus | 12.20 | 9.62 | 83 | 232608 | 37743 | 64228298 |
Knee arthroplasty | 12.15 | 9.62 | 53 | 232638 | 26946 | 64239095 |
Coma acidotic | 12.14 | 9.62 | 7 | 232684 | 128 | 64265913 |
Erythema marginatum | 12.13 | 9.62 | 4 | 232687 | 16 | 64266025 |
Hallucination | 12.12 | 9.62 | 187 | 232504 | 72601 | 64193440 |
Breast pain | 12.05 | 9.62 | 54 | 232637 | 7007 | 64259034 |
Urine albumin/creatinine ratio increased | 12.01 | 9.62 | 10 | 232681 | 338 | 64265703 |
Benign prostatic hyperplasia | 12.00 | 9.62 | 65 | 232626 | 9100 | 64256941 |
Tubulointerstitial nephritis | 11.97 | 9.62 | 167 | 232524 | 30742 | 64235299 |
Joint swelling | 11.95 | 9.62 | 645 | 232046 | 214737 | 64051304 |
Eructation | 11.91 | 9.62 | 65 | 232626 | 9126 | 64256915 |
Nocturia | 11.91 | 9.62 | 75 | 232616 | 11090 | 64254951 |
Malaise | 11.86 | 9.62 | 1617 | 231074 | 394630 | 63871411 |
Cardiac valve fibroelastoma | 11.82 | 9.62 | 3 | 232688 | 3 | 64266038 |
Creatinine renal clearance increased | 11.80 | 9.62 | 15 | 232676 | 841 | 64265200 |
Cardiac neoplasm unspecified | 11.70 | 9.62 | 5 | 232686 | 46 | 64265995 |
Duplicate therapy error | 11.68 | 9.62 | 8 | 232683 | 200 | 64265841 |
Microalbuminuria | 11.67 | 9.62 | 15 | 232676 | 850 | 64265191 |
Electrocardiogram abnormal | 11.66 | 9.62 | 86 | 232605 | 13395 | 64252646 |
Hypercalcaemia | 11.66 | 9.62 | 66 | 232625 | 31350 | 64234691 |
Autoimmune nephritis | 11.64 | 9.62 | 12 | 232679 | 535 | 64265506 |
Vertigo | 11.63 | 9.62 | 287 | 232404 | 58724 | 64207317 |
Flatulence | 11.59 | 9.62 | 187 | 232504 | 35479 | 64230562 |
Blood urine present | 11.58 | 9.62 | 109 | 232582 | 18231 | 64247810 |
Pre-eclampsia | 11.58 | 9.62 | 4 | 232687 | 6227 | 64259814 |
Coordination abnormal | 11.57 | 9.62 | 93 | 232598 | 14871 | 64251170 |
Decubitus ulcer | 11.56 | 9.62 | 19 | 232672 | 13360 | 64252681 |
Palmar-plantar erythrodysaesthesia syndrome | 11.55 | 9.62 | 59 | 232632 | 28760 | 64237281 |
Hypochromasia | 11.45 | 9.62 | 13 | 232678 | 647 | 64265394 |
Liver function test abnormal | 11.44 | 9.62 | 288 | 232403 | 59113 | 64206928 |
Myoglobinuria | 11.44 | 9.62 | 16 | 232675 | 984 | 64265057 |
Bronchial secretion retention | 11.43 | 9.62 | 27 | 232664 | 2500 | 64263541 |
Toxic cataract | 11.42 | 9.62 | 4 | 232687 | 20 | 64266021 |
Oedema genital | 11.38 | 9.62 | 11 | 232680 | 453 | 64265588 |
Pneumonia aspiration | 11.38 | 9.62 | 148 | 232543 | 59123 | 64206918 |
Upper-airway cough syndrome | 11.35 | 9.62 | 62 | 232629 | 8708 | 64257333 |
Electrocardiogram QT prolonged | 11.31 | 9.62 | 210 | 232481 | 79238 | 64186803 |
Pulmonary arterial pressure abnormal | 11.27 | 9.62 | 13 | 232678 | 658 | 64265383 |
Non-alcoholic steatohepatitis | 11.27 | 9.62 | 23 | 232668 | 1929 | 64264112 |
Cardiac autonomic neuropathy | 11.25 | 9.62 | 5 | 232686 | 51 | 64265990 |
Blood pressure ambulatory increased | 11.25 | 9.62 | 5 | 232686 | 51 | 64265990 |
Hypertriglyceridaemia | 11.17 | 9.62 | 74 | 232617 | 11131 | 64254910 |
Expired product administered | 11.14 | 9.62 | 47 | 232644 | 5940 | 64260101 |
Retroperitoneal fibrosis | 11.14 | 9.62 | 12 | 232679 | 563 | 64265478 |
Infected dermal cyst | 11.11 | 9.62 | 14 | 232677 | 778 | 64265263 |
Psychotic disorder | 11.09 | 9.62 | 76 | 232615 | 34502 | 64231539 |
Product monitoring error | 11.03 | 9.62 | 3 | 232688 | 5451 | 64260590 |
Peripheral sensorimotor neuropathy | 11.03 | 9.62 | 27 | 232664 | 2558 | 64263483 |
Seronegative arthritis | 11.02 | 9.62 | 28 | 232663 | 2715 | 64263326 |
Chronic cutaneous lupus erythematosus | 10.96 | 9.62 | 8 | 232683 | 222 | 64265819 |
Eyelid disorder | 10.92 | 9.62 | 19 | 232672 | 1412 | 64264629 |
Premature labour | 10.92 | 9.62 | 7 | 232684 | 7613 | 64258428 |
Heart rate decreased | 10.91 | 9.62 | 268 | 232423 | 54799 | 64211242 |
Monoparesis | 10.81 | 9.62 | 29 | 232662 | 2905 | 64263136 |
Neuropathy peripheral | 10.81 | 9.62 | 332 | 232359 | 117193 | 64148848 |
Oral candidiasis | 10.80 | 9.62 | 45 | 232646 | 23167 | 64242874 |
Left ventricular dilatation | 10.79 | 9.62 | 15 | 232676 | 917 | 64265124 |
Hypercreatininaemia | 10.79 | 9.62 | 14 | 232677 | 801 | 64265240 |
Low density lipoprotein abnormal | 10.79 | 9.62 | 9 | 232682 | 305 | 64265736 |
Metastases to liver | 10.78 | 9.62 | 47 | 232644 | 23894 | 64242147 |
Grip strength decreased | 10.74 | 9.62 | 16 | 232675 | 11708 | 64254333 |
Endometriosis | 10.70 | 9.62 | 28 | 232663 | 2764 | 64263277 |
Hepatosplenomegaly | 10.70 | 9.62 | 3 | 232688 | 5340 | 64260701 |
Neoplasm | 10.70 | 9.62 | 52 | 232639 | 6979 | 64259062 |
Strangulated hernia | 10.68 | 9.62 | 5 | 232686 | 58 | 64265983 |
Ejection fraction decreased | 10.67 | 9.62 | 154 | 232537 | 28553 | 64237488 |
Fear of injection | 10.63 | 9.62 | 4 | 232687 | 5908 | 64260133 |
Rheumatoid factor positive | 10.62 | 9.62 | 78 | 232613 | 34860 | 64231181 |
Peripheral artery restenosis | 10.61 | 9.62 | 3 | 232688 | 6 | 64266035 |
Prostatomegaly | 10.61 | 9.62 | 29 | 232662 | 2938 | 64263103 |
Diabetic nephropathy | 10.57 | 9.62 | 27 | 232664 | 2627 | 64263414 |
Flushing | 10.55 | 9.62 | 210 | 232481 | 78438 | 64187603 |
Epstein-Barr virus infection | 10.54 | 9.62 | 18 | 232673 | 12470 | 64253571 |
Urine ketone body present | 10.53 | 9.62 | 31 | 232660 | 3276 | 64262765 |
Muscle mass | 10.53 | 9.62 | 10 | 232681 | 403 | 64265638 |
Diaphragm muscle weakness | 10.51 | 9.62 | 7 | 232684 | 167 | 64265874 |
Hypogammaglobulinaemia | 10.51 | 9.62 | 13 | 232678 | 10286 | 64255755 |
Dermatitis bullous | 10.48 | 9.62 | 77 | 232614 | 11977 | 64254064 |
Schizophrenia | 10.47 | 9.62 | 15 | 232676 | 11153 | 64254888 |
Malignant neoplasm of ampulla of Vater | 10.42 | 9.62 | 4 | 232687 | 27 | 64266014 |
Abscess of salivary gland | 10.42 | 9.62 | 4 | 232687 | 27 | 64266014 |
Abortion induced | 10.41 | 9.62 | 5 | 232686 | 6383 | 64259658 |
Atheroembolism | 10.34 | 9.62 | 8 | 232683 | 243 | 64265798 |
Left ventricular dysfunction | 10.33 | 9.62 | 100 | 232591 | 16854 | 64249187 |
Delusion | 10.32 | 9.62 | 32 | 232659 | 17982 | 64248059 |
Staphylococcal infection | 10.31 | 9.62 | 125 | 232566 | 50553 | 64215488 |
Contraindication to surgery | 10.30 | 9.62 | 3 | 232688 | 7 | 64266034 |
Accident at work | 10.23 | 9.62 | 15 | 232676 | 964 | 64265077 |
Sinus tachycardia | 10.20 | 9.62 | 71 | 232620 | 32117 | 64233924 |
Body mass index decreased | 10.18 | 9.62 | 11 | 232680 | 518 | 64265523 |
Hypokinesia | 10.17 | 9.62 | 98 | 232593 | 16498 | 64249543 |
Bradypnoea | 10.14 | 9.62 | 3 | 232688 | 5156 | 64260885 |
Dyspnoea | 10.14 | 9.62 | 2824 | 229867 | 715850 | 63550191 |
Blood pressure diastolic increased | 10.12 | 9.62 | 70 | 232621 | 10682 | 64255359 |
Pseudomonas infection | 10.08 | 9.62 | 32 | 232659 | 17851 | 64248190 |
Transaminases abnormal | 10.03 | 9.62 | 13 | 232678 | 743 | 64265298 |
Reduced facial expression | 10.02 | 9.62 | 23 | 232668 | 2090 | 64263951 |
Idiopathic interstitial pneumonia | 10.02 | 9.62 | 7 | 232684 | 181 | 64265860 |
Hypervolaemia | 10.01 | 9.62 | 89 | 232602 | 38196 | 64227845 |
Enthesopathy | 10.01 | 9.62 | 12 | 232679 | 9626 | 64256415 |
Ventricular extrasystoles | 10.00 | 9.62 | 102 | 232589 | 17427 | 64248614 |
Campylobacter test positive | 9.98 | 9.62 | 5 | 232686 | 68 | 64265973 |
Complication associated with device | 9.97 | 9.62 | 25 | 232666 | 15055 | 64250986 |
Infusion site scar | 9.95 | 9.62 | 8 | 232683 | 257 | 64265784 |
Pulmonary tuberculosis | 9.91 | 9.62 | 7 | 232684 | 7237 | 64258804 |
Left atrial dilatation | 9.85 | 9.62 | 27 | 232664 | 2739 | 64263302 |
Blood bicarbonate decreased | 9.85 | 9.62 | 39 | 232652 | 4790 | 64261251 |
Acute respiratory failure | 9.84 | 9.62 | 124 | 232567 | 49810 | 64216231 |
Potentiating drug interaction | 9.82 | 9.62 | 55 | 232636 | 7797 | 64258244 |
Anxiety | 9.78 | 9.62 | 615 | 232076 | 202034 | 64064007 |
Apnoea | 9.77 | 9.62 | 14 | 232677 | 10408 | 64255633 |
Conjunctivitis | 9.76 | 9.62 | 39 | 232652 | 20315 | 64245726 |
Liver injury | 9.75 | 9.62 | 157 | 232534 | 29775 | 64236266 |
Obstructive pancreatitis | 9.75 | 9.62 | 12 | 232679 | 651 | 64265390 |
Walking disability | 9.74 | 9.62 | 21 | 232670 | 1830 | 64264211 |
Atelectasis | 9.73 | 9.62 | 58 | 232633 | 27208 | 64238833 |
Polycystic ovaries | 9.72 | 9.62 | 23 | 232668 | 2132 | 64263909 |
Unevaluable event | 9.72 | 9.62 | 126 | 232565 | 50363 | 64215678 |
Gout | 9.67 | 9.62 | 119 | 232572 | 21294 | 64244747 |
Incontinence | 9.67 | 9.62 | 18 | 232673 | 12063 | 64253978 |
Normocytic anaemia | 9.64 | 9.62 | 30 | 232661 | 3269 | 64262772 |
Arteriovenous fistula site haematoma | 9.63 | 9.62 | 4 | 232687 | 34 | 64266007 |
None
Source | Code | Description |
---|---|---|
ATC | A10BH52 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Dipeptidyl peptidase 4 (DPP-4) inhibitors |
ATC | C10AA07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN HMG CoA reductase inhibitors |
ATC | C10BA06 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BA07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BA09 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BX05 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX09 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX10 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX13 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX14 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX16 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX17 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA MoA | N0000000121 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
FDA EPC | N0000175589 | HMG-CoA Reductase Inhibitor |
MeSH PA | D000924 | Anticholesteremic Agents |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
MeSH PA | D000960 | Hypolipidemic Agents |
MeSH PA | D057847 | Lipid Regulating Agents |
CHEBI has role | CHEBI:35679 | antilipemic drugs |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:49205 | CETP inhibitors |
CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
CHEBI has role | CHEBI:77307 | cardioprotective agents |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypercholesterolemia | indication | 13644009 | |
Arteriosclerotic vascular disease | indication | 72092001 | |
Cerebrovascular accident | indication | 230690007 | |
Familial hypercholesterolemia - homozygous | indication | 238078005 | |
Familial hypercholesterolemia - heterozygous | indication | 238079002 | |
Mixed hyperlipidemia | indication | 267434003 | |
Hypertriglyceridemia | indication | 302870006 | |
Familial type 3 hyperlipoproteinemia | indication | 398796005 | DOID:3145 |
Prevention of Transient Ischemic Attacks | indication | ||
Primary Prevention of Coronary Heart Disease | indication | ||
Myocardial Infarction Prevention | indication | ||
Alcoholism | contraindication | 7200002 | |
Proteinuria | contraindication | 29738008 | DOID:576 |
Dehydration | contraindication | 34095006 | |
Blood in urine | contraindication | 34436003 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Acute nephropathy | contraindication | 58574008 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Liver function tests abnormal | contraindication | 166603001 | |
Hemorrhagic cerebral infarction | contraindication | 230706003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Rhabdomyolysis | contraindication | 240131006 | |
Pregnancy, function | contraindication | 289908002 | |
Surgical procedure | contraindication | 387713003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Traumatic injury | contraindication | 417746004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.29 | acidic |
pKa2 | 13.84 | acidic |
pKa3 | 3.67 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
10MG;EQ 10MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | RX | TABLET | ORAL | 10376470 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 10MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | RX | TABLET | ORAL | 9763885 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 20MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | RX | TABLET | ORAL | 10376470 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 20MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | RX | TABLET | ORAL | 9763885 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 40MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | RX | TABLET | ORAL | 10376470 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 40MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | RX | TABLET | ORAL | 9763885 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 5MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | RX | TABLET | ORAL | 10376470 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 5MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | RX | TABLET | ORAL | 9763885 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 10MG BASE | CRESTOR | IPR | N021366 | Aug. 12, 2003 | RX | TABLET | ORAL | May 27, 2023 | AN ADJUNCT TO DIET TO REDUCE LDL-C, TOTAL-C, NONHDL-C AND APOB IN CHILDREN AND ADOLESCENTS 7 TO 17 YEARS OF AGE WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, EITHER ALONE OR WITH OTHER LIPID-LOWERING TREATMENTS (E.G., LDL APHERESIS) |
EQ 20MG BASE | CRESTOR | IPR | N021366 | Aug. 12, 2003 | RX | TABLET | ORAL | May 27, 2023 | AN ADJUNCT TO DIET TO REDUCE LDL-C, TOTAL-C, NONHDL-C AND APOB IN CHILDREN AND ADOLESCENTS 7 TO 17 YEARS OF AGE WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, EITHER ALONE OR WITH OTHER LIPID-LOWERING TREATMENTS (E.G., LDL APHERESIS) |
EQ 40MG BASE | CRESTOR | IPR | N021366 | Aug. 12, 2003 | RX | TABLET | ORAL | May 27, 2023 | AN ADJUNCT TO DIET TO REDUCE LDL-C, TOTAL-C, NONHDL-C AND APOB IN CHILDREN AND ADOLESCENTS 7 TO 17 YEARS OF AGE WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, EITHER ALONE OR WITH OTHER LIPID-LOWERING TREATMENTS (E.G., LDL APHERESIS) |
EQ 5MG BASE | CRESTOR | IPR | N021366 | Aug. 12, 2003 | RX | TABLET | ORAL | May 27, 2023 | AN ADJUNCT TO DIET TO REDUCE LDL-C, TOTAL-C, NONHDL-C AND APOB IN CHILDREN AND ADOLESCENTS 7 TO 17 YEARS OF AGE WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, EITHER ALONE OR WITH OTHER LIPID-LOWERING TREATMENTS (E.G., LDL APHERESIS) |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | INHIBITOR | Ki | 9.05 | CHEMBL | CHEMBL | |||
Phosphodiesterase 6D | Enzyme | Kd | 5.90 | CHEMBL | |||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | IC50 | 8.68 | CHEMBL |
ID | Source |
---|---|
4021405 | VUID |
N0000148821 | NUI |
D01915 | KEGG_DRUG |
147098-20-2 | SECONDARY_CAS_RN |
4021405 | VANDF |
C0965129 | UMLSCUI |
CHEBI:38545 | CHEBI |
FBI | PDB_CHEM_ID |
CHEMBL1496 | ChEMBL_ID |
CHEMBL1744447 | ChEMBL_ID |
D000068718 | MESH_DESCRIPTOR_UI |
DB01098 | DRUGBANK_ID |
2954 | IUPHAR_LIGAND_ID |
8021 | INN_ID |
953412-08-3 | SECONDARY_CAS_RN |
413KH5ZJ73 | UNII |
446157 | PUBCHEM_CID |
301542 | RXNORM |
107656 | MMSL |
17146 | MMSL |
17536 | MMSL |
34243 | MMSL |
46321 | MMSL |
d04851 | MMSL |
009902 | NDDF |
009903 | NDDF |
406435003 | SNOMEDCT_US |
700067006 | SNOMEDCT_US |
768151007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0751 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0751 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0752 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0752 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0754 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0754 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0755 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0755 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 27 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7560 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7570 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7580 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7580 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7590 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7590 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 29 sections |
Rosuvastatin calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5400 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
Rosuvastatin calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5401 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 26 sections |
Rosuvastatin calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5402 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 26 sections |
Rosuvastatin calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5403 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 26 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6778 | TABLET, COATED | 5 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6779 | TABLET, COATED | 10 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6780 | TABLET, COATED | 20 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6781 | TABLET, COATED | 40 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-179 | TABLET, COATED | 5 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-179 | TABLET, COATED | 5 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-180 | TABLET, COATED | 10 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-180 | TABLET, COATED | 10 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-181 | TABLET, COATED | 20 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-181 | TABLET, COATED | 20 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-182 | TABLET, COATED | 40 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-182 | TABLET, COATED | 40 mg | ORAL | ANDA | 21 sections |