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neomycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, produced by Streptomyces strains	4247	1405-10-3

Description:

Molecule	Description
Synonyms: neomycin sulfate neomycin bykomycin endomixin fradiomycin sulfate mycerin sulfate neomycin sulphate neomycin palmitate	Aminoglycoside antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C, and acts by inhibiting translation during protein synthesis. Molecular weight: 1551.66 Formula: C58H118N16O32 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

neomycin sulfate
neomycin
bykomycin
endomixin
fradiomycin sulfate
mycerin sulfate
neomycin sulphate
neomycin palmitate

Aminoglycoside antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C, and acts by inhibiting translation during protein synthesis.

Molecular weight: 1551.66
Formula: C58H118N16O32
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
5	g	O
1	g	P

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	3 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
March 26, 1957	FDA	MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	383.94	16.47	373	11461	310314	63166874
Macular degeneration	258.42	16.47	114	11720	24262	63452926
Toxic anterior segment syndrome	96.70	16.47	28	11806	1743	63475445
Type 2 diabetes mellitus	86.43	16.47	81	11753	63787	63413401
C-reactive protein	79.33	16.47	31	11803	4851	63472337
Swollen joint count increased	61.21	16.47	52	11782	36002	63441186
Rheumatic fever	55.10	16.47	53	11781	43058	63434130
Chronic sinusitis	48.28	16.47	30	11804	12813	63464375
Lip dry	47.94	16.47	32	11802	15438	63461750
Helicobacter infection	46.69	16.47	71	11763	92714	63384474

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	71.99	17.38	63	3634	80466	34872768
Staphylococcal skin infection	32.11	17.38	9	3688	885	34952349
Staphylococcal scalded skin syndrome	25.63	17.38	6	3691	287	34952947
Retinitis	23.75	17.38	6	3691	396	34952838
Renal injury	19.35	17.38	13	3684	11182	34942052
Mucosal inflammation	19.17	17.38	22	3675	38600	34914634
Vanishing bile duct syndrome	18.24	17.38	6	3691	1012	34952222
Multiple organ dysfunction syndrome	17.45	17.38	30	3667	76536	34876698

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	250.61	14.78	272	12487	298644	79432985
Toxic anterior segment syndrome	101.23	14.78	31	12728	2733	79728896
C-reactive protein	79.69	14.78	30	12729	4949	79726680
Swollen joint count increased	74.07	14.78	46	12713	22881	79708748
Rheumatic fever	67.24	14.78	47	12712	28478	79703151
Macular degeneration	64.70	14.78	33	12726	11263	79720366
Type 2 diabetes mellitus	52.93	14.78	55	12704	57067	79674562
Injury	50.29	14.78	62	12697	77434	79654195
Sciatica	50.18	14.78	42	12717	33180	79698449
Lip dry	47.44	14.78	30	12729	15388	79716241

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A01AB08	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment
ATC	A07AA01	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Antibiotics
ATC	A07AA51	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Antibiotics
ATC	B05CA09	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Antiinfectives
ATC	D06AX04	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use
ATC	J01GB05	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMINOGLYCOSIDE ANTIBACTERIALS Other aminoglycosides
ATC	R02AB01	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antibiotics
ATC	S01AA03	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
ATC	S02AA07	SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives
ATC	S03AA01	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Keratitis	indication	5888003	DOID:4677
Hepatic encephalopathy	indication	13920009	DOID:13413
Urinary tract infectious disease	indication	68566005
Blepharoconjunctivitis	indication	68659002	DOID:2456
Hepatic coma	indication	72836002	DOID:12550
Corneal abrasion	indication	85848002
Uveitis	indication	128473001	DOID:13141
Infective blepharitis	indication	312219000
Bacterial keratitis	indication	314557000

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🐶 Veterinary Drug Use

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Species	Use	Relation
Cats	Bacterial infections	Indication
Cats	Wound infections	Indication
Cats	Superficial ocular bacterial infections limited to the conjunctival or the anterior segment of the eye	Indication
Cattle	Colibacillosis caused by Escherichia coli	Indication
Dogs	Bacterial infections	Indication
Dogs	Bacterial diarrhea	Indication
Dogs	Wound infections	Indication
Dogs	Superficial ocular bacterial infections limited to the conjunctival or the anterior segment of the eye	Indication
Goats	Colibacillosis caused by Escherichia coli	Indication
Horses	Ear and skin conditions caused by organisms	Indication

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🐶 Veterinary products

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Product	Applicant	Ingredients
Anaprime Ophthalmic Solution	Zoetis Inc.	3
Anaprime Opthakote Ophthalmic	Zoetis Inc.	3
Animax Cream	Fougera Pharmaceuticals Inc.	4
Animax Ointment	Fougera Pharmaceuticals Inc.	4
Bac-Neo-Poly Ophthalmic Ointment, Vetropolycin Ophthalmic Ointment	Dechra, Ltd.	3
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment	Dechra, Ltd.	4
Biosol Liquid	Zoetis Inc.	1
Biosol Sterile Solution, Biosol Sterile Solution 50 mg	Zoetis Inc.	1
Cortisporin Veterinary Ophthalmic Ointment	Intervet Inc.	4
Derm-Otic Ointment	Zoetis Inc.	4

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Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Transient receptor potential cation channel subfamily V member 1	Ion channel	Q8NER1	TRPV1_HUMAN		IC50	6.40	CHEMBL
Lecithin retinol acyltransferase	Enzyme	O95237	LRAT_HUMAN		IC50	4.83	CHEMBL
Menin	Unclassified	O00255	MEN1_HUMAN		Kd	4.81	CHEMBL
Lethal factor	Enzyme		LEF_BACAN		Ki	6.30	CHEMBL
Extracellular calcium-sensing receptor	GPCR		CASR_RAT	AGONIST	Kd	4	IUPHAR

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External reference:

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ID	Source
NMY	PDB_CHEM_ID
002775	NDDF
002777	NDDF
1404-04-2	SECONDARY_CAS_RN
2184	MMSL
232	INN_ID
35157	MMSL
373528008	SNOMEDCT_US
4017501	VANDF
4017991	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
AntibioticMaximum Strength	HUMAN OTC DRUG LABEL	3	0363-0018	OINTMENT	3.50 mg	TOPICAL	OTC monograph final	13 sections
AntibioticMaximum Strength	HUMAN OTC DRUG LABEL	3	0363-0018	OINTMENT	3.50 mg	TOPICAL	OTC monograph final	13 sections
basic care first aid antibiotic	HUMAN OTC DRUG LABEL	3	0113-0701	OINTMENT	3.50 mg	TOPICAL	OTC monograph final	13 sections
Basic Care First Aid Antibiotic Plus Pain Relief	HUMAN OTC DRUG LABEL	4	0113-7679	OINTMENT	3.50 mg	TOPICAL	OTC monograph final	13 sections
First Aid Antibiotic	HUMAN OTC DRUG LABEL	4	0363-0841	OINTMENT	3.50 mg	TOPICAL	OTC monograph final	13 sections
First Aid Antibiotic	HUMAN OTC DRUG LABEL	4	0363-0841	OINTMENT	3.50 mg	TOPICAL	OTC monograph final	13 sections
Good Sense First Aid Antibiotic	HUMAN OTC DRUG LABEL	3	0113-0084	OINTMENT	3.50 mg	TOPICAL	OTC monograph final	13 sections
good sense triple antibiotic	HUMAN OTC DRUG LABEL	4	0113-1140	OINTMENT	3.50 mg	TOPICAL	OTC monograph final	13 sections
Good Sense Triple Antibioticand Pain Relief	HUMAN OTC DRUG LABEL	4	0113-0679	OINTMENT	3.50 mg	TOPICAL	OTC monograph final	13 sections
MAXITROL	HUMAN PRESCRIPTION DRUG LABEL	3	0065-0631	OINTMENT	3.50 mg	OPHTHALMIC	NDA	18 sections

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