Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, produced by Streptomyces strains | 2684 | 32986-56-4 |
Dose | Unit | Route |
---|---|---|
0.11 | g | Inhal.powder |
0.30 | g | Inhal.solution |
0.24 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 50 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 93 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.25 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.23 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.60 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 20, 2011 | EMA | MYLAN IRELAND LIMITED | |
June 11, 1975 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Infective pulmonary exacerbation of cystic fibrosis | 1810.75 | 14.39 | 433 | 17397 | 8384 | 63462808 |
Hospitalisation | 560.31 | 14.39 | 329 | 17501 | 84752 | 63386440 |
Cystic fibrosis | 383.56 | 14.39 | 103 | 17727 | 3193 | 63467999 |
Pulmonary function test decreased | 259.33 | 14.39 | 79 | 17751 | 3868 | 63467324 |
Pseudomonas infection | 245.76 | 14.39 | 99 | 17731 | 11114 | 63460078 |
Haemoptysis | 191.01 | 14.39 | 112 | 17718 | 28614 | 63442578 |
Acute kidney injury | 171.91 | 14.39 | 283 | 17547 | 263132 | 63208060 |
Cough | 150.18 | 14.39 | 283 | 17547 | 292460 | 63178732 |
Pneumonia | 130.98 | 14.39 | 350 | 17480 | 456417 | 63014775 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 116.64 | 14.39 | 40 | 17790 | 2859 | 63468333 |
Renal tubular necrosis | 111.05 | 14.39 | 58 | 17772 | 11820 | 63459372 |
Death | 90.56 | 14.39 | 270 | 17560 | 374111 | 63097081 |
Ventilation perfusion mismatch | 88.57 | 14.39 | 22 | 17808 | 496 | 63470696 |
Forced expiratory volume decreased | 82.45 | 14.39 | 36 | 17794 | 4932 | 63466260 |
Sputum increased | 80.10 | 14.39 | 29 | 17801 | 2430 | 63468762 |
Cystic fibrosis respiratory infection suppression | 78.59 | 14.39 | 18 | 17812 | 283 | 63470909 |
Corneal perforation | 77.51 | 14.39 | 20 | 17810 | 528 | 63470664 |
Bronchiectasis | 77.03 | 14.39 | 51 | 17779 | 16091 | 63455101 |
Cystic fibrosis lung | 76.02 | 14.39 | 15 | 17815 | 109 | 63471083 |
Ototoxicity | 71.62 | 14.39 | 23 | 17807 | 1339 | 63469853 |
Hypopyon | 67.22 | 14.39 | 19 | 17811 | 713 | 63470479 |
Proteinuria | 66.93 | 14.39 | 50 | 17780 | 19095 | 63452097 |
Aplastic anaemia | 65.39 | 14.39 | 38 | 17792 | 9531 | 63461661 |
Disease complication | 62.33 | 14.39 | 26 | 17804 | 3183 | 63468009 |
Conjunctival hyperaemia | 59.07 | 14.39 | 23 | 17807 | 2356 | 63468836 |
Staphylococcal infection | 58.76 | 14.39 | 65 | 17765 | 41191 | 63430001 |
Corneal oedema | 57.73 | 14.39 | 20 | 17810 | 1473 | 63469719 |
Bronchospasm | 55.70 | 14.39 | 43 | 17787 | 17237 | 63453955 |
Infection | 54.99 | 14.39 | 165 | 17665 | 229008 | 63242184 |
Antibiotic level above therapeutic | 54.61 | 14.39 | 14 | 17816 | 360 | 63470832 |
Drug resistance | 52.90 | 14.39 | 47 | 17783 | 22886 | 63448306 |
Dysphonia | 52.82 | 14.39 | 66 | 17764 | 47548 | 63423644 |
Vasculitis | 51.59 | 14.39 | 42 | 17788 | 18167 | 63453025 |
Endophthalmitis | 49.94 | 14.39 | 23 | 17807 | 3569 | 63467623 |
Lung disorder | 48.90 | 14.39 | 73 | 17757 | 62188 | 63409004 |
Tinnitus | 48.79 | 14.39 | 55 | 17775 | 35573 | 63435619 |
Pneumonia pseudomonal | 47.45 | 14.39 | 20 | 17810 | 2513 | 63468679 |
Systemic lupus erythematosus | 46.84 | 14.39 | 3 | 17827 | 208915 | 63262277 |
Lung transplant | 46.55 | 14.39 | 21 | 17809 | 3107 | 63468085 |
Drug level increased | 45.43 | 14.39 | 43 | 17787 | 22693 | 63448499 |
Corneal infiltrates | 45.29 | 14.39 | 10 | 17820 | 132 | 63471060 |
Off label use | 44.88 | 14.39 | 333 | 17497 | 674129 | 62797063 |
Dyspnoea | 43.71 | 14.39 | 326 | 17504 | 660987 | 62810205 |
Pneumothorax | 42.93 | 14.39 | 36 | 17794 | 16225 | 63454967 |
Synovitis | 40.98 | 14.39 | 3 | 17827 | 186915 | 63284277 |
Pseudomonas test positive | 40.84 | 14.39 | 13 | 17817 | 735 | 63470457 |
Glossodynia | 38.84 | 14.39 | 3 | 17827 | 178873 | 63292319 |
Deafness | 37.88 | 14.39 | 35 | 17795 | 17922 | 63453270 |
SLE arthritis | 37.86 | 14.39 | 12 | 17818 | 669 | 63470523 |
Eye irritation | 37.28 | 14.39 | 38 | 17792 | 21933 | 63449259 |
Abdominal discomfort | 37.23 | 14.39 | 22 | 17808 | 320863 | 63150329 |
Wound | 34.72 | 14.39 | 3 | 17827 | 163260 | 63307932 |
Overlap syndrome | 34.63 | 14.39 | 12 | 17818 | 884 | 63470308 |
Aphonia | 34.54 | 14.39 | 26 | 17804 | 10037 | 63461155 |
Acute generalised exanthematous pustulosis | 34.43 | 14.39 | 27 | 17803 | 11072 | 63460120 |
Chest discomfort | 34.08 | 14.39 | 87 | 17743 | 109882 | 63361310 |
Arthropathy | 33.57 | 14.39 | 12 | 17818 | 234780 | 63236412 |
Burkholderia cepacia complex infection | 33.50 | 14.39 | 8 | 17822 | 152 | 63471040 |
Ulcerative keratitis | 33.50 | 14.39 | 16 | 17814 | 2694 | 63468498 |
Productive cough | 33.35 | 14.39 | 62 | 17768 | 63146 | 63408046 |
Pain | 32.92 | 14.39 | 103 | 17727 | 740525 | 62730667 |
Condition aggravated | 32.82 | 14.39 | 209 | 17621 | 402008 | 63069184 |
Swelling | 31.76 | 14.39 | 19 | 17811 | 275359 | 63195833 |
Retinopathy of prematurity | 31.53 | 14.39 | 9 | 17821 | 350 | 63470842 |
Drug reaction with eosinophilia and systemic symptoms | 29.95 | 14.39 | 42 | 17788 | 33794 | 63437398 |
Ocular hyperaemia | 29.73 | 14.39 | 36 | 17794 | 25108 | 63446084 |
Infusion related reaction | 29.66 | 14.39 | 16 | 17814 | 245505 | 63225687 |
Nephropathy toxic | 29.27 | 14.39 | 23 | 17807 | 9456 | 63461736 |
Visual acuity reduced | 28.70 | 14.39 | 33 | 17797 | 21793 | 63449399 |
Elbow deformity | 28.50 | 14.39 | 12 | 17818 | 1503 | 63469689 |
Stenotrophomonas infection | 28.24 | 14.39 | 13 | 17817 | 2014 | 63469178 |
Keratitis fungal | 28.09 | 14.39 | 7 | 17823 | 160 | 63471032 |
Sweat test abnormal | 28.05 | 14.39 | 5 | 17825 | 19 | 63471173 |
Pathogen resistance | 27.62 | 14.39 | 19 | 17811 | 6379 | 63464813 |
Corneal epithelium defect | 27.25 | 14.39 | 8 | 17822 | 344 | 63470848 |
Infective exacerbation of bronchiectasis | 27.23 | 14.39 | 8 | 17822 | 345 | 63470847 |
Pneumonia staphylococcal | 26.55 | 14.39 | 14 | 17816 | 2906 | 63468286 |
Hypoxia | 25.91 | 14.39 | 54 | 17776 | 59738 | 63411454 |
Drug ineffective | 25.33 | 14.39 | 181 | 17649 | 1044584 | 62426608 |
Corneal neovascularisation | 25.28 | 14.39 | 6 | 17824 | 111 | 63471081 |
Therapeutic product effect incomplete | 24.77 | 14.39 | 3 | 17827 | 125053 | 63346139 |
Lipogranuloma | 24.67 | 14.39 | 4 | 17826 | 7 | 63471185 |
Mobility decreased | 23.77 | 14.39 | 3 | 17827 | 121156 | 63350036 |
Sputum discoloured | 23.69 | 14.39 | 26 | 17804 | 16321 | 63454871 |
Injection site pain | 23.64 | 14.39 | 4 | 17826 | 129796 | 63341396 |
Increased bronchial secretion | 23.59 | 14.39 | 11 | 17819 | 1755 | 63469437 |
Peripheral swelling | 23.51 | 14.39 | 24 | 17806 | 265918 | 63205274 |
Rhinovirus infection | 23.29 | 14.39 | 15 | 17815 | 4514 | 63466678 |
Eyelid oedema | 23.22 | 14.39 | 21 | 17809 | 10458 | 63460734 |
Alopecia | 23.08 | 14.39 | 37 | 17793 | 337499 | 63133693 |
Vitritis | 22.56 | 14.39 | 9 | 17821 | 983 | 63470209 |
Jaw fracture | 22.18 | 14.39 | 12 | 17818 | 2622 | 63468570 |
Ocular hypertension | 22.06 | 14.39 | 9 | 17821 | 1041 | 63470151 |
Distal intestinal obstruction syndrome | 21.74 | 14.39 | 7 | 17823 | 411 | 63470781 |
Corneal opacity | 21.38 | 14.39 | 8 | 17822 | 735 | 63470457 |
Respirovirus test positive | 20.66 | 14.39 | 4 | 17826 | 26 | 63471166 |
Corneal thinning | 20.33 | 14.39 | 5 | 17825 | 108 | 63471084 |
Corneal disorder | 20.28 | 14.39 | 10 | 17820 | 1804 | 63469388 |
Product administered to patient of inappropriate age | 19.77 | 14.39 | 12 | 17818 | 3256 | 63467936 |
Respiratory tract infection bacterial | 19.74 | 14.39 | 6 | 17824 | 291 | 63470901 |
Retinal detachment | 19.55 | 14.39 | 15 | 17815 | 5954 | 63465238 |
Pancreatic failure | 19.06 | 14.39 | 8 | 17822 | 995 | 63470197 |
Keratitis bacterial | 18.87 | 14.39 | 4 | 17826 | 43 | 63471149 |
Therapy cessation | 18.79 | 14.39 | 32 | 17798 | 30425 | 63440767 |
Sinonasal papilloma | 18.70 | 14.39 | 4 | 17826 | 45 | 63471147 |
Discomfort | 18.66 | 14.39 | 12 | 17818 | 167362 | 63303830 |
Foreign body sensation in eyes | 18.32 | 14.39 | 10 | 17820 | 2224 | 63468968 |
Bronchopulmonary aspergillosis allergic | 18.22 | 14.39 | 10 | 17820 | 2248 | 63468944 |
Anterior chamber fibrin | 18.03 | 14.39 | 4 | 17826 | 54 | 63471138 |
Contusion | 17.78 | 14.39 | 10 | 17820 | 150034 | 63321158 |
Fall | 17.76 | 14.39 | 54 | 17776 | 392280 | 63078912 |
Eye pain | 17.59 | 14.39 | 33 | 17797 | 33821 | 63437371 |
Clubbing | 17.34 | 14.39 | 6 | 17824 | 440 | 63470752 |
Bronchial disorder | 17.12 | 14.39 | 8 | 17822 | 1282 | 63469910 |
Pupillary block | 16.71 | 14.39 | 3 | 17827 | 12 | 63471180 |
Spirometry abnormal | 16.58 | 14.39 | 5 | 17825 | 236 | 63470956 |
Respiratory disorder | 16.58 | 14.39 | 35 | 17795 | 39047 | 63432145 |
Respiration abnormal | 16.51 | 14.39 | 14 | 17816 | 6403 | 63464789 |
Aspergilloma | 16.24 | 14.39 | 5 | 17825 | 253 | 63470939 |
Overdose | 16.23 | 14.39 | 6 | 17824 | 115072 | 63356120 |
Bronchial wall thickening | 15.98 | 14.39 | 8 | 17822 | 1491 | 63469701 |
Intentional product use issue | 15.92 | 14.39 | 8 | 17822 | 127884 | 63343308 |
Renal failure | 15.63 | 14.39 | 70 | 17760 | 117582 | 63353610 |
Lower respiratory tract infection | 15.42 | 14.39 | 9 | 17821 | 132298 | 63338894 |
Bartter's syndrome | 15.18 | 14.39 | 3 | 17827 | 22 | 63471170 |
Blastomycosis | 15.14 | 14.39 | 5 | 17825 | 318 | 63470874 |
Confusional state | 15.14 | 14.39 | 27 | 17803 | 236353 | 63234839 |
Intraocular pressure increased | 15.10 | 14.39 | 13 | 17817 | 6065 | 63465127 |
Perineal necrosis | 14.92 | 14.39 | 4 | 17826 | 123 | 63471069 |
Forced expiratory volume increased | 14.84 | 14.39 | 3 | 17827 | 25 | 63471167 |
Central nervous system fungal infection | 14.82 | 14.39 | 4 | 17826 | 126 | 63471066 |
Multiple organ dysfunction syndrome | 14.65 | 14.39 | 42 | 17788 | 56710 | 63414482 |
Tracheostomy infection | 14.54 | 14.39 | 3 | 17827 | 28 | 63471164 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Infective pulmonary exacerbation of cystic fibrosis | 1581.22 | 16.65 | 401 | 14604 | 6400 | 34935526 |
Hospitalisation | 444.40 | 16.65 | 286 | 14719 | 56616 | 34885310 |
Cystic fibrosis | 279.89 | 16.65 | 76 | 14929 | 1582 | 34940344 |
Pulmonary function test decreased | 204.97 | 16.65 | 78 | 14927 | 4897 | 34937029 |
Pseudomonas infection | 199.08 | 16.65 | 100 | 14905 | 12282 | 34929644 |
Choroiditis | 178.75 | 16.65 | 50 | 14955 | 1165 | 34940761 |
Endophthalmitis | 155.38 | 16.65 | 58 | 14947 | 3450 | 34938476 |
Eye pain | 144.15 | 16.65 | 83 | 14922 | 13379 | 34928547 |
Intraocular pressure increased | 141.10 | 16.65 | 61 | 14944 | 5322 | 34936604 |
Ototoxicity | 128.00 | 16.65 | 43 | 14962 | 1874 | 34940052 |
Cough | 120.36 | 16.65 | 224 | 14781 | 149916 | 34792010 |
Haemoptysis | 118.35 | 16.65 | 107 | 14898 | 34899 | 34907027 |
Visual acuity reduced | 110.69 | 16.65 | 75 | 14930 | 16074 | 34925852 |
Pneumonia | 109.35 | 16.65 | 372 | 14633 | 362255 | 34579671 |
Condition aggravated | 100.70 | 16.65 | 241 | 14764 | 191955 | 34749971 |
Cystic fibrosis respiratory infection suppression | 90.35 | 16.65 | 21 | 14984 | 224 | 34941702 |
Infection | 90.05 | 16.65 | 149 | 14856 | 90766 | 34851160 |
Uveitis | 84.78 | 16.65 | 48 | 14957 | 7487 | 34934439 |
Sputum discoloured | 83.16 | 16.65 | 48 | 14957 | 7764 | 34934162 |
Productive cough | 80.57 | 16.65 | 90 | 14915 | 37723 | 34904203 |
Forced expiratory volume decreased | 76.48 | 16.65 | 34 | 14971 | 3169 | 34938757 |
Sputum increased | 69.20 | 16.65 | 29 | 14976 | 2341 | 34939585 |
Renal tubular necrosis | 65.25 | 16.65 | 54 | 14951 | 15626 | 34926300 |
Disease complication | 65.19 | 16.65 | 29 | 14976 | 2707 | 34939219 |
Painful respiration | 64.24 | 16.65 | 23 | 14982 | 1213 | 34940713 |
Aplastic anaemia | 61.55 | 16.65 | 43 | 14962 | 9673 | 34932253 |
Pathogen resistance | 55.52 | 16.65 | 40 | 14965 | 9442 | 34932484 |
Lung disorder | 54.89 | 16.65 | 71 | 14934 | 34625 | 34907301 |
Bronchospasm | 53.28 | 16.65 | 41 | 14964 | 10690 | 34931236 |
Lung transplant | 53.24 | 16.65 | 23 | 14982 | 2001 | 34939925 |
Chest injury | 51.64 | 16.65 | 21 | 14984 | 1570 | 34940356 |
Dyspnoea | 49.63 | 16.65 | 303 | 14702 | 376479 | 34565447 |
Walking aid user | 47.79 | 16.65 | 21 | 14984 | 1903 | 34940023 |
Drug resistance | 47.31 | 16.65 | 57 | 14948 | 25870 | 34916056 |
Retinopathy of prematurity | 44.78 | 16.65 | 11 | 14994 | 151 | 34941775 |
Pancreatic failure | 42.04 | 16.65 | 15 | 14990 | 783 | 34941143 |
Increased viscosity of bronchial secretion | 41.34 | 16.65 | 11 | 14994 | 211 | 34941715 |
Linear IgA disease | 41.21 | 16.65 | 18 | 14987 | 1608 | 34940318 |
Product administered to patient of inappropriate age | 39.83 | 16.65 | 22 | 14983 | 3269 | 34938657 |
Hypoacusis | 38.53 | 16.65 | 41 | 14964 | 16260 | 34925666 |
Cystic fibrosis related diabetes | 38.39 | 16.65 | 10 | 14995 | 176 | 34941750 |
Nephropathy toxic | 37.71 | 16.65 | 36 | 14969 | 12552 | 34929374 |
Respiratory tract irritation | 36.46 | 16.65 | 10 | 14995 | 216 | 34941710 |
Pneumonia pseudomonal | 36.24 | 16.65 | 22 | 14983 | 3900 | 34938026 |
Oxygen saturation decreased | 35.34 | 16.65 | 74 | 14931 | 53744 | 34888182 |
Infective exacerbation of bronchiectasis | 33.88 | 16.65 | 11 | 14994 | 430 | 34941496 |
Toxic epidermal necrolysis | 33.76 | 16.65 | 44 | 14961 | 21602 | 34920324 |
Pseudomonas test positive | 33.58 | 16.65 | 14 | 14991 | 1115 | 34940811 |
Deafness | 33.33 | 16.65 | 32 | 14973 | 11233 | 34930693 |
Distal intestinal obstruction syndrome | 31.97 | 16.65 | 10 | 14995 | 346 | 34941580 |
Tinnitus | 31.54 | 16.65 | 41 | 14964 | 20077 | 34921849 |
Deafness neurosensory | 31.51 | 16.65 | 18 | 14987 | 2853 | 34939073 |
Aphonia | 31.37 | 16.65 | 19 | 14986 | 3354 | 34938572 |
Respiratory disorder | 31.36 | 16.65 | 40 | 14965 | 19224 | 34922702 |
Bronchiectasis | 31.21 | 16.65 | 29 | 14976 | 9772 | 34932154 |
Ill-defined disorder | 31.14 | 16.65 | 34 | 14971 | 13875 | 34928051 |
Influenza | 31.11 | 16.65 | 67 | 14938 | 49599 | 34892327 |
Vestibular disorder | 30.50 | 16.65 | 13 | 14992 | 1094 | 34940832 |
Fall | 29.78 | 16.65 | 26 | 14979 | 202859 | 34739067 |
Increased bronchial secretion | 29.64 | 16.65 | 15 | 14990 | 1866 | 34940060 |
Somnolence | 29.32 | 16.65 | 6 | 14999 | 111110 | 34830816 |
Arthralgia | 28.52 | 16.65 | 19 | 14986 | 170022 | 34771904 |
Staphylococcal infection | 27.53 | 16.65 | 50 | 14955 | 32710 | 34909216 |
Aortic aneurysm | 27.47 | 16.65 | 23 | 14982 | 6756 | 34935170 |
Corneal epithelium defect | 27.28 | 16.65 | 9 | 14996 | 370 | 34941556 |
Acute kidney injury | 26.98 | 16.65 | 223 | 14782 | 304765 | 34637161 |
Death | 26.63 | 16.65 | 274 | 14731 | 397775 | 34544151 |
Rhonchi | 26.35 | 16.65 | 14 | 14991 | 1926 | 34940000 |
Cystic fibrosis lung | 26.35 | 16.65 | 6 | 14999 | 58 | 34941868 |
Wheezing | 26.10 | 16.65 | 56 | 14949 | 41346 | 34900580 |
Oral candidiasis | 26.07 | 16.65 | 29 | 14976 | 12081 | 34929845 |
Rash morbilliform | 25.19 | 16.65 | 16 | 14989 | 3071 | 34938855 |
Keratitis bacterial | 24.87 | 16.65 | 6 | 14999 | 76 | 34941850 |
Product use issue | 23.53 | 16.65 | 70 | 14935 | 63146 | 34878780 |
Toxic anterior segment syndrome | 23.47 | 16.65 | 11 | 14994 | 1158 | 34940768 |
Rubber sensitivity | 22.87 | 16.65 | 7 | 14998 | 225 | 34941701 |
Ulcerative keratitis | 22.14 | 16.65 | 12 | 14993 | 1717 | 34940209 |
Chest discomfort | 21.85 | 16.65 | 62 | 14943 | 54468 | 34887458 |
Mycobacterium chelonae infection | 20.58 | 16.65 | 9 | 14996 | 806 | 34941120 |
Chondritis | 20.53 | 16.65 | 6 | 14999 | 164 | 34941762 |
Scleromalacia | 19.86 | 16.65 | 4 | 15001 | 20 | 34941906 |
Cronobacter infection | 19.86 | 16.65 | 4 | 15001 | 20 | 34941906 |
Necrotising scleritis | 19.82 | 16.65 | 5 | 15000 | 77 | 34941849 |
Flavobacterium infection | 19.58 | 16.65 | 5 | 15000 | 81 | 34941845 |
Febrile convulsion | 19.41 | 16.65 | 8 | 14997 | 619 | 34941307 |
Aspergillus infection | 19.24 | 16.65 | 25 | 14980 | 12229 | 34929697 |
Chronic sinusitis | 19.07 | 16.65 | 12 | 14993 | 2267 | 34939659 |
Malignant neoplasm progression | 19.02 | 16.65 | 7 | 14998 | 88039 | 34853887 |
Feeling cold | 18.76 | 16.65 | 23 | 14982 | 10616 | 34931310 |
Neuralgic amyotrophy | 18.57 | 16.65 | 6 | 14999 | 231 | 34941695 |
Keratitis | 18.39 | 16.65 | 10 | 14995 | 1441 | 34940485 |
Hypotony of eye | 18.27 | 16.65 | 5 | 15000 | 107 | 34941819 |
Trichosporon infection | 18.19 | 16.65 | 8 | 14997 | 726 | 34941200 |
Lipogranuloma | 18.18 | 16.65 | 3 | 15002 | 3 | 34941923 |
Carbon dioxide increased | 18.15 | 16.65 | 9 | 14996 | 1072 | 34940854 |
Malaise | 18.08 | 16.65 | 139 | 14866 | 185686 | 34756240 |
Nausea | 17.98 | 16.65 | 80 | 14925 | 339828 | 34602098 |
Device related thrombosis | 17.59 | 16.65 | 9 | 14996 | 1146 | 34940780 |
Cholangitis infective | 17.54 | 16.65 | 6 | 14999 | 276 | 34941650 |
Ocular hyperaemia | 17.42 | 16.65 | 23 | 14982 | 11429 | 34930497 |
Tracheostomy | 17.19 | 16.65 | 8 | 14997 | 829 | 34941097 |
Hypertension | 17.13 | 16.65 | 20 | 14985 | 136423 | 34805503 |
Ocular hypertension | 17.12 | 16.65 | 8 | 14997 | 836 | 34941090 |
Anaemia | 16.94 | 16.65 | 48 | 14957 | 233287 | 34708639 |
Staphylococcal sepsis | 16.91 | 16.65 | 21 | 14984 | 9823 | 34932103 |
Keratitis fungal | 16.83 | 16.65 | 5 | 15000 | 145 | 34941781 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Infective pulmonary exacerbation of cystic fibrosis | 2553.67 | 13.59 | 633 | 25426 | 12218 | 79706111 |
Hospitalisation | 719.04 | 13.59 | 423 | 25636 | 93813 | 79624516 |
Cystic fibrosis | 501.46 | 13.59 | 136 | 25923 | 3744 | 79714585 |
Pulmonary function test decreased | 351.40 | 13.59 | 121 | 25938 | 7516 | 79710813 |
Pseudomonas infection | 277.96 | 13.59 | 136 | 25923 | 20767 | 79697562 |
Haemoptysis | 252.59 | 13.59 | 181 | 25878 | 55818 | 79662511 |
Acute kidney injury | 190.59 | 13.59 | 480 | 25579 | 518924 | 79199405 |
Renal tubular necrosis | 189.44 | 13.59 | 112 | 25947 | 24927 | 79693402 |
Ototoxicity | 178.72 | 13.59 | 59 | 26000 | 3215 | 79715114 |
Choroiditis | 171.85 | 13.59 | 47 | 26012 | 1334 | 79716995 |
Endophthalmitis | 170.64 | 13.59 | 68 | 25991 | 6360 | 79711969 |
Intraocular pressure increased | 147.13 | 13.59 | 68 | 25991 | 9137 | 79709192 |
Pneumonia | 144.43 | 13.59 | 508 | 25551 | 659738 | 79058591 |
Cough | 133.19 | 13.59 | 338 | 25721 | 366451 | 79351878 |
Disease complication | 126.79 | 13.59 | 51 | 26008 | 4886 | 79713443 |
Visual acuity reduced | 125.40 | 13.59 | 92 | 25967 | 29377 | 79688952 |
Aplastic anaemia | 124.82 | 13.59 | 76 | 25983 | 17829 | 79700500 |
Cystic fibrosis respiratory infection suppression | 124.79 | 13.59 | 29 | 26030 | 415 | 79717914 |
Forced expiratory volume decreased | 122.63 | 13.59 | 57 | 26002 | 7757 | 79710572 |
Sputum increased | 119.67 | 13.59 | 48 | 26011 | 4565 | 79713764 |
Eye pain | 115.89 | 13.59 | 97 | 25962 | 37481 | 79680848 |
Drug resistance | 98.39 | 13.59 | 93 | 25966 | 42120 | 79676209 |
Cystic fibrosis lung | 93.92 | 13.59 | 19 | 26040 | 134 | 79718195 |
Corneal perforation | 90.46 | 13.59 | 25 | 26034 | 738 | 79717591 |
Death | 86.53 | 13.59 | 390 | 25669 | 566124 | 79152205 |
Sputum discoloured | 83.84 | 13.59 | 64 | 25995 | 21679 | 79696650 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 83.76 | 13.59 | 35 | 26024 | 3694 | 79714635 |
Condition aggravated | 83.36 | 13.59 | 354 | 25705 | 500770 | 79217559 |
Pathogen resistance | 82.72 | 13.59 | 54 | 26005 | 14288 | 79704041 |
Ventilation perfusion mismatch | 80.65 | 13.59 | 22 | 26037 | 618 | 79717711 |
Pneumonia pseudomonal | 74.20 | 13.59 | 37 | 26022 | 5874 | 79712455 |
Lung transplant | 73.84 | 13.59 | 34 | 26025 | 4527 | 79713802 |
Uveitis | 72.62 | 13.59 | 53 | 26006 | 16777 | 79701552 |
Productive cough | 71.59 | 13.59 | 114 | 25945 | 88217 | 79630112 |
Bronchiectasis | 71.53 | 13.59 | 59 | 26000 | 22327 | 79696002 |
Ulcerative keratitis | 70.88 | 13.59 | 31 | 26028 | 3658 | 79714671 |
Bronchospasm | 70.16 | 13.59 | 61 | 25998 | 24798 | 79693531 |
Nephropathy toxic | 69.85 | 13.59 | 56 | 26003 | 20363 | 79697966 |
Tinnitus | 69.57 | 13.59 | 79 | 25980 | 44254 | 79674075 |
Hypopyon | 68.07 | 13.59 | 22 | 26037 | 1120 | 79717209 |
Completed suicide | 67.57 | 13.59 | 3 | 26056 | 245764 | 79472565 |
Corneal oedema | 63.62 | 13.59 | 26 | 26033 | 2594 | 79715735 |
Staphylococcal infection | 61.26 | 13.59 | 85 | 25974 | 58210 | 79660119 |
Drug level increased | 61.10 | 13.59 | 70 | 25989 | 39581 | 79678748 |
Conjunctival hyperaemia | 56.51 | 13.59 | 28 | 26031 | 4385 | 79713944 |
Antibiotic level above therapeutic | 55.54 | 13.59 | 17 | 26042 | 723 | 79717606 |
Corneal infiltrates | 55.11 | 13.59 | 14 | 26045 | 296 | 79718033 |
Infective exacerbation of bronchiectasis | 54.79 | 13.59 | 17 | 26042 | 757 | 79717572 |
Dyspnoea | 48.45 | 13.59 | 459 | 25600 | 856566 | 78861763 |
Fall | 48.22 | 13.59 | 53 | 26006 | 487576 | 79230753 |
Aphonia | 47.98 | 13.59 | 34 | 26025 | 10278 | 79708051 |
Corneal epithelium defect | 47.59 | 13.59 | 15 | 26044 | 704 | 79717625 |
Painful respiration | 47.48 | 13.59 | 23 | 26036 | 3430 | 79714899 |
Lung disorder | 47.04 | 13.59 | 90 | 25969 | 80467 | 79637862 |
Pancreatic failure | 45.93 | 13.59 | 18 | 26041 | 1610 | 79716719 |
Chest injury | 45.57 | 13.59 | 21 | 26038 | 2800 | 79715529 |
Keratitis fungal | 44.87 | 13.59 | 12 | 26047 | 312 | 79718017 |
Cystic fibrosis related diabetes | 44.12 | 13.59 | 11 | 26048 | 215 | 79718114 |
Pseudomonas test positive | 43.68 | 13.59 | 18 | 26041 | 1834 | 79716495 |
Ocular hypertension | 43.56 | 13.59 | 17 | 26042 | 1503 | 79716826 |
Lipogranuloma | 42.98 | 13.59 | 7 | 26052 | 10 | 79718319 |
Product administered to patient of inappropriate age | 42.40 | 13.59 | 25 | 26034 | 5528 | 79712801 |
Increased viscosity of bronchial secretion | 42.29 | 13.59 | 13 | 26046 | 561 | 79717768 |
Distal intestinal obstruction syndrome | 42.22 | 13.59 | 14 | 26045 | 773 | 79717556 |
Linear IgA disease | 40.48 | 13.59 | 20 | 26039 | 3112 | 79715217 |
Acute generalised exanthematous pustulosis | 40.16 | 13.59 | 38 | 26021 | 17216 | 79701113 |
Therapeutic product effect decreased | 39.22 | 13.59 | 4 | 26055 | 163859 | 79554470 |
Hypoacusis | 37.89 | 13.59 | 48 | 26011 | 30102 | 79688227 |
Deafness neurosensory | 37.42 | 13.59 | 25 | 26034 | 6873 | 79711456 |
Deafness | 37.34 | 13.59 | 40 | 26019 | 20997 | 79697332 |
Infection | 37.17 | 13.59 | 167 | 25892 | 241545 | 79476784 |
Corneal neovascularisation | 37.17 | 13.59 | 9 | 26050 | 155 | 79718174 |
Pneumothorax | 37.04 | 13.59 | 46 | 26013 | 28277 | 79690052 |
Increased bronchial secretion | 36.45 | 13.59 | 19 | 26040 | 3308 | 79715021 |
Off label use | 36.43 | 13.59 | 454 | 25605 | 906761 | 78811568 |
Ocular hyperaemia | 35.59 | 13.59 | 45 | 26014 | 28161 | 79690168 |
Corneal opacity | 34.96 | 13.59 | 13 | 26046 | 1007 | 79717322 |
Toxic epidermal necrolysis | 34.01 | 13.59 | 56 | 26003 | 44525 | 79673804 |
Necrotising scleritis | 33.55 | 13.59 | 9 | 26050 | 237 | 79718092 |
Pain | 32.16 | 13.59 | 120 | 25939 | 703682 | 79014647 |
Keratitis bacterial | 32.01 | 13.59 | 8 | 26051 | 158 | 79718171 |
Stenotrophomonas infection | 31.50 | 13.59 | 18 | 26041 | 3755 | 79714574 |
Respiratory disorder | 31.10 | 13.59 | 54 | 26005 | 44802 | 79673527 |
Swelling | 31.08 | 13.59 | 16 | 26043 | 216695 | 79501634 |
Aortic aneurysm | 30.68 | 13.59 | 24 | 26035 | 8422 | 79709907 |
Proteinuria | 30.62 | 13.59 | 45 | 26014 | 32457 | 79685872 |
Rhinovirus infection | 29.76 | 13.59 | 23 | 26036 | 7930 | 79710399 |
SLE arthritis | 29.63 | 13.59 | 10 | 26049 | 583 | 79717746 |
Mobility decreased | 29.19 | 13.59 | 3 | 26056 | 122172 | 79596157 |
Injection site pain | 29.01 | 13.59 | 4 | 26055 | 129834 | 79588495 |
Systemic lupus erythematosus | 28.88 | 13.59 | 3 | 26056 | 121146 | 79597183 |
Vasculitis | 28.48 | 13.59 | 38 | 26021 | 25064 | 79693265 |
Scleromalacia | 28.26 | 13.59 | 6 | 26053 | 55 | 79718274 |
Forced expiratory volume increased | 28.17 | 13.59 | 6 | 26053 | 56 | 79718273 |
Trichosporon infection | 27.92 | 13.59 | 11 | 26048 | 997 | 79717332 |
Syncope | 27.64 | 13.59 | 12 | 26047 | 179437 | 79538892 |
Somnolence | 27.04 | 13.59 | 23 | 26036 | 238958 | 79479371 |
Burkholderia cepacia complex infection | 26.85 | 13.59 | 8 | 26051 | 310 | 79718019 |
Vestibular disorder | 26.84 | 13.59 | 14 | 26045 | 2441 | 79715888 |
Mycobacterium chelonae infection | 26.83 | 13.59 | 14 | 26045 | 2442 | 79715887 |
Bronchopulmonary aspergillosis allergic | 26.62 | 13.59 | 15 | 26044 | 3046 | 79715283 |
Chest discomfort | 26.39 | 13.59 | 102 | 25957 | 137942 | 79580387 |
Eyelid oedema | 26.02 | 13.59 | 27 | 26032 | 13660 | 79704669 |
Arthropathy | 25.50 | 13.59 | 13 | 26046 | 177098 | 79541231 |
Toxic anterior segment syndrome | 25.28 | 13.59 | 14 | 26045 | 2750 | 79715579 |
Respiratory tract irritation | 25.28 | 13.59 | 9 | 26050 | 616 | 79717713 |
Abdominal discomfort | 25.02 | 13.59 | 27 | 26032 | 250700 | 79467629 |
Vitritis | 24.82 | 13.59 | 12 | 26047 | 1782 | 79716547 |
Dysphonia | 24.38 | 13.59 | 56 | 26003 | 56816 | 79661513 |
Overlap syndrome | 24.31 | 13.59 | 10 | 26049 | 1014 | 79717315 |
Intentional overdose | 24.31 | 13.59 | 3 | 26056 | 105957 | 79612372 |
Keratitis | 24.25 | 13.59 | 16 | 26043 | 4306 | 79714023 |
Clubbing | 24.10 | 13.59 | 9 | 26050 | 706 | 79717623 |
Hypotony of eye | 24.02 | 13.59 | 7 | 26052 | 251 | 79718078 |
Infusion related reaction | 23.87 | 13.59 | 24 | 26035 | 230213 | 79488116 |
Pericarditis | 23.79 | 13.59 | 3 | 26056 | 104233 | 79614096 |
Oxygen saturation decreased | 23.57 | 13.59 | 94 | 25965 | 128953 | 79589376 |
Glossodynia | 23.52 | 13.59 | 3 | 26056 | 103334 | 79614995 |
Rash morbilliform | 23.48 | 13.59 | 18 | 26041 | 6132 | 79712197 |
Aspergillus infection | 23.28 | 13.59 | 30 | 26029 | 19131 | 79699198 |
Multiple organ dysfunction syndrome | 23.11 | 13.59 | 89 | 25970 | 120157 | 79598172 |
Eye irritation | 22.99 | 13.59 | 31 | 26028 | 20650 | 79697679 |
Wound | 22.85 | 13.59 | 5 | 26054 | 116174 | 79602155 |
Rhonchi | 22.79 | 13.59 | 15 | 26044 | 4021 | 79714308 |
Malignant neoplasm progression | 22.75 | 13.59 | 8 | 26051 | 135982 | 79582347 |
Influenza | 22.55 | 13.59 | 93 | 25966 | 129513 | 79588816 |
Pneumonia staphylococcal | 22.51 | 13.59 | 16 | 26043 | 4858 | 79713471 |
Overdose | 21.74 | 13.59 | 17 | 26042 | 184189 | 79534140 |
Pain in extremity | 21.70 | 13.59 | 55 | 26004 | 364483 | 79353846 |
Arthralgia | 21.47 | 13.59 | 105 | 25954 | 571698 | 79146631 |
Corneal thinning | 21.40 | 13.59 | 6 | 26053 | 187 | 79718142 |
Respiratory distress | 21.31 | 13.59 | 54 | 26005 | 58285 | 79660044 |
Walking aid user | 21.08 | 13.59 | 21 | 26038 | 10127 | 79708202 |
Cronobacter infection | 20.95 | 13.59 | 4 | 26055 | 20 | 79718309 |
Macular oedema | 20.85 | 13.59 | 16 | 26043 | 5458 | 79712871 |
Wheezing | 20.52 | 13.59 | 84 | 25975 | 116580 | 79601749 |
Bronchial wall thickening | 20.45 | 13.59 | 12 | 26047 | 2629 | 79715700 |
Elbow deformity | 20.36 | 13.59 | 10 | 26049 | 1537 | 79716792 |
Flavobacterium infection | 20.04 | 13.59 | 5 | 26054 | 98 | 79718231 |
Discomfort | 19.99 | 13.59 | 8 | 26051 | 125609 | 79592720 |
Gait disturbance | 19.98 | 13.59 | 23 | 26036 | 207483 | 79510846 |
Respiration abnormal | 19.76 | 13.59 | 18 | 26041 | 7770 | 79710559 |
Hypertension | 19.65 | 13.59 | 50 | 26009 | 330942 | 79387387 |
Gastrointestinal haemorrhage | 19.59 | 13.59 | 12 | 26047 | 147707 | 79570622 |
Anaemia | 19.55 | 13.59 | 77 | 25982 | 444938 | 79273391 |
Therapeutic product effect incomplete | 19.50 | 13.59 | 11 | 26048 | 141634 | 79576695 |
Hypoaesthesia | 19.39 | 13.59 | 18 | 26041 | 179334 | 79538995 |
Sputum abnormal | 19.14 | 13.59 | 9 | 26050 | 1256 | 79717073 |
Drug reaction with eosinophilia and systemic symptoms | 18.99 | 13.59 | 55 | 26004 | 64189 | 79654140 |
Neuralgic amyotrophy | 18.98 | 13.59 | 6 | 26053 | 284 | 79718045 |
Sweat test abnormal | 18.62 | 13.59 | 4 | 26055 | 39 | 79718290 |
Oral candidiasis | 18.40 | 13.59 | 34 | 26025 | 29594 | 79688735 |
Haemodialysis | 18.34 | 13.59 | 26 | 26033 | 18142 | 79700187 |
Febrile convulsion | 18.34 | 13.59 | 8 | 26051 | 938 | 79717391 |
Post procedural complication | 18.26 | 13.59 | 30 | 26029 | 23799 | 79694530 |
Sinonasal papilloma | 18.18 | 13.59 | 4 | 26055 | 44 | 79718285 |
Erythema of eyelid | 18.14 | 13.59 | 11 | 26048 | 2559 | 79715770 |
Underweight | 18.04 | 13.59 | 8 | 26051 | 975 | 79717354 |
Restrictive cardiomyopathy | 17.85 | 13.59 | 8 | 26051 | 1000 | 79717329 |
Pulmonary haemorrhage | 17.81 | 13.59 | 23 | 26036 | 14694 | 79703635 |
Chondritis | 17.70 | 13.59 | 5 | 26054 | 160 | 79718169 |
Respiratory tract infection bacterial | 17.58 | 13.59 | 10 | 26049 | 2067 | 79716262 |
Fatigue | 17.57 | 13.59 | 207 | 25852 | 929520 | 78788809 |
Anterior chamber fibrin | 17.38 | 13.59 | 5 | 26054 | 171 | 79718158 |
Stenotrophomonas test positive | 17.38 | 13.59 | 6 | 26053 | 375 | 79717954 |
Therapy cessation | 17.23 | 13.59 | 38 | 26021 | 37524 | 79680805 |
Muscle spasms | 17.22 | 13.59 | 19 | 26040 | 174711 | 79543618 |
Contusion | 17.21 | 13.59 | 14 | 26045 | 148762 | 79569567 |
Pyrexia | 16.77 | 13.59 | 313 | 25746 | 678396 | 79039933 |
Corneal disorder | 16.67 | 13.59 | 10 | 26049 | 2281 | 79716048 |
Surgical procedure repeated | 16.59 | 13.59 | 7 | 26052 | 757 | 79717572 |
Staphylococcal sepsis | 16.26 | 13.59 | 22 | 26037 | 14704 | 79703625 |
Psoriatic arthropathy | 16.08 | 13.59 | 3 | 26056 | 77996 | 79640333 |
Bronchial disorder | 15.91 | 13.59 | 10 | 26049 | 2479 | 79715850 |
Vitamin A deficiency | 15.51 | 13.59 | 4 | 26055 | 90 | 79718239 |
Blood creatinine increased | 15.42 | 13.59 | 95 | 25964 | 154962 | 79563367 |
Alopecia | 15.28 | 13.59 | 33 | 26026 | 231322 | 79487007 |
Muscular weakness | 15.27 | 13.59 | 18 | 26041 | 160711 | 79557618 |
Intentional product misuse | 15.24 | 13.59 | 6 | 26053 | 95159 | 79623170 |
Interstitial lung disease | 15.14 | 13.59 | 9 | 26050 | 112591 | 79605738 |
Vitamin E deficiency | 15.11 | 13.59 | 3 | 26056 | 19 | 79718310 |
Infectious crystalline keratopathy | 14.98 | 13.59 | 3 | 26056 | 20 | 79718309 |
Scedosporium infection | 14.94 | 13.59 | 8 | 26051 | 1470 | 79716859 |
Osteoarthritis | 14.83 | 13.59 | 5 | 26054 | 87304 | 79631025 |
Dermatitis exfoliative | 14.82 | 13.59 | 18 | 26041 | 10811 | 79707518 |
Bacterial infection | 14.75 | 13.59 | 32 | 26027 | 31248 | 79687081 |
Loss of consciousness | 14.72 | 13.59 | 20 | 26039 | 167923 | 79550406 |
Herpes zoster | 14.69 | 13.59 | 6 | 26053 | 93077 | 79625252 |
Bartter's syndrome | 14.61 | 13.59 | 3 | 26056 | 23 | 79718306 |
Staphylococcus test positive | 14.56 | 13.59 | 14 | 26045 | 6467 | 79711862 |
Carbon dioxide increased | 14.32 | 13.59 | 9 | 26050 | 2231 | 79716098 |
Angle closure glaucoma | 14.28 | 13.59 | 10 | 26049 | 2966 | 79715363 |
Jaw fracture | 14.16 | 13.59 | 10 | 26049 | 3007 | 79715322 |
Injection site erythema | 14.14 | 13.59 | 4 | 26055 | 78193 | 79640136 |
Hypoxia | 14.13 | 13.59 | 69 | 25990 | 103174 | 79615155 |
Perineal necrosis | 14.07 | 13.59 | 4 | 26055 | 131 | 79718198 |
Cholangitis infective | 14.02 | 13.59 | 6 | 26053 | 671 | 79717658 |
Confusional state | 13.97 | 13.59 | 55 | 26004 | 317942 | 79400387 |
Moaning | 13.92 | 13.59 | 7 | 26052 | 1130 | 79717199 |
Osteopenia | 13.91 | 13.59 | 23 | 26036 | 18341 | 79699988 |
Vitamin E decreased | 13.90 | 13.59 | 3 | 26056 | 30 | 79718299 |
Respirovirus test positive | 13.85 | 13.59 | 4 | 26055 | 139 | 79718190 |
Dizziness | 13.83 | 13.59 | 108 | 25951 | 526333 | 79191996 |
Conjunctival oedema | 13.80 | 13.59 | 7 | 26052 | 1151 | 79717178 |
Cognitive disorder | 13.77 | 13.59 | 3 | 26056 | 69923 | 79648406 |
Retinal detachment | 13.69 | 13.59 | 16 | 26043 | 9231 | 79709098 |
Suicide attempt | 13.66 | 13.59 | 5 | 26054 | 82927 | 79635402 |
Corneal erosion | 13.60 | 13.59 | 5 | 26054 | 375 | 79717954 |
Lip haemorrhage | 13.60 | 13.59 | 7 | 26052 | 1187 | 79717142 |
None
Source | Code | Description |
---|---|---|
ATC | J01GB01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMINOGLYCOSIDE ANTIBACTERIALS Other aminoglycosides |
ATC | S01AA12 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
FDA CS | M0000946 | Aminoglycosides |
FDA EPC | N0000175477 | Aminoglycoside Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:27026 | toxins |
CHEBI has role | CHEBI:33281 | antibiotics |
CHEBI has role | CHEBI:33282 | bactericides |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Septicemia due to Escherichia coli | indication | 9323009 | |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Staphylococcal pneumonia | indication | 22754005 | |
Pneumonia due to Pseudomonas | indication | 41381004 | |
Punctate keratitis | indication | 42513006 | DOID:12197 |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
Infection due to Escherichia coli | indication | 71057007 | |
Bacterial infection due to Serratia | indication | 71120004 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Perforation of cornea | indication | 74895004 | |
Dacryocystitis | indication | 85777005 | DOID:9938 |
Corneal abrasion | indication | 85848002 | |
Keratoconjunctivitis | indication | 88151007 | DOID:9368 |
Bacterial meningitis | indication | 95883001 | DOID:9470 |
Infection of bone | indication | 111253001 | |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Uveitis | indication | 128473001 | DOID:13141 |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Bacterial peritonitis | indication | 197171003 | |
Sepsis of the newborn | indication | 206376005 | |
Neonatal meningitis | indication | 276674008 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Meibomianitis | indication | 309779001 | |
Bacterial urinary infection | indication | 312124009 | |
Infective blepharitis | indication | 312219000 | |
Herpes zoster keratitis | indication | 397573005 | |
Rosacea | indication | 398909004 | DOID:8881 |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Anterior uveitis | indication | 410692006 | DOID:1407 |
Nosocomial pneumonia | indication | 425464007 | |
Osteomyelitis due to Staphylococcus aureus | indication | 428783003 | |
Sepsis due to Pseudomonas | indication | 448813005 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
Synergy for Nosocomial Pneumonia due to Pseudomonas Aeruginosa | indication | ||
Synergy for Neonatal Meningitis | indication | ||
Klebsiella Pneumoniae Peritonitis | indication | ||
Proteus Mirabilis Osteomyelitis | indication | ||
E. Coli Osteomyelitis | indication | ||
Skin and Skin Structure Proteus Infection | indication | ||
Complicated UTI with Pseudomonas Aeruginosa | indication | ||
Gram-Negative Aerobic Bacillary Pneumonia | indication | ||
Klebsiella Pneumoniae Osteomyelitis | indication | ||
Synergy for Staphylococcal Infections | indication | ||
Staphylococcus Aureus Complicated UTI | indication | ||
Complicated Proteus UTI | indication | ||
Citrobacter Complicated UTI | indication | ||
Enterobacter Osteomyelitis | indication | ||
Synergy for P. Aeruginosa Infection in Cystic Fibrosis | indication | ||
E. Coli Peritonitis | indication | ||
Complicated Urinary Tract Infections | indication | ||
Synergy for Bacterial Meningitis | indication | ||
Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
Enterobacter Pneumonia | indication | ||
Pseudomonas Aeruginosa Osteomyelitis | indication | ||
Serratia Complicated UTI | indication | ||
Providencia Complicated UTI | indication | ||
Pyrexia of unknown origin | off-label use | 7520000 | |
Exposure keratoconjunctivitis | off-label use | 14366000 | DOID:9461 |
Neuropathic corneal ulcer | off-label use | 231901007 | |
Superficial Ocular Infection | off-label use | ||
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Hypocalcemia | contraindication | 5291005 | |
Herpes simplex keratitis | contraindication | 9389005 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Herpes simplex dendritic keratitis | contraindication | 29943008 | |
Fungal infection of eye | contraindication | 31194008 | |
Parkinsonism | contraindication | 32798002 | |
Dehydration | contraindication | 34095006 | |
Severe myopia | contraindication | 34187009 | |
Tuberculosis of eye | contraindication | 49107007 | |
Tinnitus | contraindication | 60862001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Krukenberg spindle | contraindication | 85430004 | |
Herpes zoster ophthalmicus | contraindication | 87513003 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Eye infection | contraindication | 128351009 | |
Bacterial infection of eye | contraindication | 128984004 | |
Hypomagnesemia | contraindication | 190855004 | |
Pregnancy, function | contraindication | 289908002 | |
Viral eye infection | contraindication | 312132001 | |
Vaccinia keratitis | contraindication | 397552005 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Vertigo | contraindication | 399153001 | |
Infant Botulism | contraindication | ||
Disorder of the 8th Cranial Nerve | contraindication | ||
Tobramycin Toxicity | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.15 | acidic |
pKa2 | 13.85 | acidic |
pKa3 | 8.34 | Basic |
pKa4 | 7.59 | Basic |
pKa5 | 6.94 | Basic |
pKa6 | 6.81 | Basic |
pKa7 | 5.55 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
28MG | TOBI PODHALER | MYLAN SPECIALITY LP | N201688 | March 22, 2013 | RX | POWDER | INHALATION | 11484671 | Nov. 7, 2024 | TREATMENT OF CYSTIC FIBROSIS PATIENTS WITH PSEUDOMONAS AERUGINOSA |
28MG | TOBI PODHALER | MYLAN SPECIALITY LP | N201688 | March 22, 2013 | RX | POWDER | INHALATION | 8664187 | June 20, 2025 | TREATMENT OF CYSTIC FIBROSIS PATIENTS WITH PSEUDOMONAS AERUGINOSA |
0.05%;0.3% | TOBRADEX ST | EYEVANCE | N050818 | Feb. 13, 2009 | RX | SUSPENSION/DROPS | OPHTHALMIC | 8101582 | Dec. 19, 2027 | USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS |
0.05%;0.3% | TOBRADEX ST | EYEVANCE | N050818 | Feb. 13, 2009 | RX | SUSPENSION/DROPS | OPHTHALMIC | 7795316 | Aug. 3, 2028 | USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS |
28MG | TOBI PODHALER | MYLAN SPECIALITY LP | N201688 | March 22, 2013 | RX | POWDER | INHALATION | 8869794 | Sept. 12, 2028 | TREATMENT OF CYSTIC FIBROSIS PATIENTS WITH PSEUDOMONAS AERUGINOSA |
28MG | TOBI PODHALER | MYLAN SPECIALITY LP | N201688 | March 22, 2013 | RX | POWDER | INHALATION | 10207066 | Nov. 4, 2030 | TREATMENT OF CYSTIC FIBROSIS PATIENTS WITH PSEUDOMONAS AERUGINOSA |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Taste receptor type 2 member 20 | GPCR | AGONIST | EC50 | 4.29 | IUPHAR | ||||
Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B) | Enzyme | Km | 5.82 | WOMBAT-PK |
ID | Source |
---|---|
4018595 | VUID |
N0000146911 | NUI |
D00063 | KEGG_DRUG |
49842-07-1 | SECONDARY_CAS_RN |
4018595 | VANDF |
4018596 | VANDF |
C0040341 | UMLSCUI |
CHEBI:28864 | CHEBI |
TOY | PDB_CHEM_ID |
CHEMBL1747 | ChEMBL_ID |
CHEMBL3989564 | ChEMBL_ID |
CHEMBL1200780 | ChEMBL_ID |
D014031 | MESH_DESCRIPTOR_UI |
DB00684 | DRUGBANK_ID |
10930 | IUPHAR_LIGAND_ID |
2990 | INN_ID |
VZ8RRZ51VK | UNII |
36294 | PUBCHEM_CID |
10627 | RXNORM |
1090 | MMSL |
182011 | MMSL |
2138 | MMSL |
5590 | MMSL |
5591 | MMSL |
5606 | MMSL |
d00069 | MMSL |
002779 | NDDF |
002780 | NDDF |
13188003 | SNOMEDCT_US |
373548001 | SNOMEDCT_US |
89695009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Tobrex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0643 | SOLUTION/ DROPS | 3 mg | OPHTHALMIC | NDA | 17 sections |
Tobrex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0643 | SOLUTION/ DROPS | 3 mg | OPHTHALMIC | NDA | 17 sections |
TOBREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0644 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 16 sections |
TOBREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0644 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 16 sections |
TobraDex | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-0647 | SUSPENSION/ DROPS | 3 mg | OPHTHALMIC | NDA | 18 sections |
TobraDex | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-0647 | SUSPENSION/ DROPS | 3 mg | OPHTHALMIC | NDA | 18 sections |
TobraDex | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-0648 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 18 sections |
TOBI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0494 | SOLUTION | 300 mg | ORAL | NDA | 30 sections |
TOBI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0494 | SOLUTION | 300 mg | ORAL | NDA | 30 sections |
TOBI Podhaler | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0630 | CAPSULE | 28 mg | ORAL | NDA | 29 sections |
TOBREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0813 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 16 sections |
TOBREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0813 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 16 sections |
TobraDex | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0876 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 18 sections |
TobraDex | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0876 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 18 sections |
TobraDex | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0876 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 18 sections |
TobraDex | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0953 | SUSPENSION/ DROPS | 3 mg | OPHTHALMIC | NDA | 18 sections |
TobraDex | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0953 | SUSPENSION/ DROPS | 3 mg | OPHTHALMIC | NDA | 18 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3750 | SOLUTION | 300 mg | RESPIRATORY (INHALATION) | ANDA | 30 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3750 | SOLUTION | 300 mg | RESPIRATORY (INHALATION) | ANDA | 30 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4085 | SOLUTION | 300 mg | RESPIRATORY (INHALATION) | ANDA | 26 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4085 | SOLUTION | 300 mg | RESPIRATORY (INHALATION) | ANDA | 26 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-7196 | SOLUTION/ DROPS | 3 mg | OPHTHALMIC | ANDA | 18 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3577 | INJECTION, SOLUTION | 10 mg | INTRAMUSCULAR | ANDA | 18 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3577 | INJECTION, SOLUTION | 10 mg | INTRAMUSCULAR | ANDA | 18 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3578 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 18 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3578 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 18 sections |
TOBRAMYCIN AND DEXAMETHASONE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0574-4031 | SUSPENSION/ DROPS | 3 mg | OPHTHALMIC | ANDA | 18 sections |
BETHKIS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10122-820 | SOLUTION | 300 mg | RESPIRATORY (INHALATION) | NDA | 34 sections |
BETHKIS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10122-820 | SOLUTION | 300 mg | RESPIRATORY (INHALATION) | NDA | 34 sections |
Tobramycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-883 | SOLUTION/ DROPS | 3 mg | OPHTHALMIC | ANDA | 18 sections |