acetic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4211 | 64-19-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 17, 1960 | FDA | HI TECH PHARMA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G01AD02 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Organic acids |
| ATC | S02AA10 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
| CHEBI has role | CHEBI:48356 | protogenic solvent |
| CHEBI has role | CHEBI:64049 | pH control agents |
| CHEBI has role | CHEBI:65256 | antimicrobial food preservatives |
| CHEBI has role | CHEBI:83056 | Daphnia magna metabolites |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D007202 | Indicators and Reagents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Otitis externa | indication | 3135009 | |
| Otalgia | off-label use | 16001004 | |
| Impacted cerumen | off-label use | 18070006 | |
| Otitis Externa Eczema | off-label use | ||
| Otitis Externa Seborrhea | off-label use | ||
| Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
| Perforation of tympanic membrane | contraindication | 60442001 | |
| Herpes simplex | contraindication | 88594005 | DOID:8566 |
| Tuberculosis of ear | contraindication | 186269001 | |
| Viral ear infection | contraindication | 312137007 | |
| Fungal ear infection | contraindication | 312148000 | |
| Infective otitis media | contraindication | 312218008 | |
| Porphyria | contraindication | 418470004 | |
| Sensation Disturbance of Genitals | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.44 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck | Kinase | Kd | 6.19 | CHEMBL | |||||
| Tyrosine-protein kinase Fyn | Kinase | Kd | 6.05 | CHEMBL | |||||
| Free fatty acid receptor 2 | GPCR | AGONIST | EC50 | 4.60 | IUPHAR | ||||
| Free fatty acid receptor 3 | GPCR | EC50 | 4.92 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018456 | VUID |
| N0000146780 | NUI |
| D00010 | KEGG_DRUG |
| 4017443 | VANDF |
| 4018456 | VANDF |
| C0000983 | UMLSCUI |
| CHEBI:15366 | CHEBI |
| ACY | PDB_CHEM_ID |
| CHEMBL539 | ChEMBL_ID |
| D019342 | MESH_DESCRIPTOR_UI |
| DB03166 | DRUGBANK_ID |
| 1058 | IUPHAR_LIGAND_ID |
| Q40Q9N063P | UNII |
| 176 | PUBCHEM_CID |
| 168 | RXNORM |
| 11539 | MMSL |
| 4122 | MMSL |
| 822 | MMSL |
| 9812 | MMSL |
| d04228 | MMSL |
| 002875 | NDDF |
| 002917 | NDDF |
| 2869004 | SNOMEDCT_US |
| 326289007 | SNOMEDCT_US |
| 422082008 | SNOMEDCT_US |
| 772941001 | SNOMEDCT_US |
| 786281009 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-2304 | IRRIGANT | 0.25 g | IRRIGATION | NDA | 21 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-2304 | IRRIGANT | 0.25 g | IRRIGATION | NDA | 21 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0656 | IRRIGANT | 250 mg | IRRIGATION | NDA | 14 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0656 | IRRIGANT | 250 mg | IRRIGATION | NDA | 14 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6143 | IRRIGANT | 250 mg | IRRIGATION | NDA | 12 sections |
| Fem pH | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0813-0799 | JELLY | 0.01 g | VAGINAL | unapproved drug other | 18 sections |
| Fem pH | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0813-0799 | JELLY | 0.01 g | VAGINAL | unapproved drug other | 18 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0990-6143 | IRRIGANT | 250 mg | IRRIGATION | NDA | 12 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0990-6143 | IRRIGANT | 250 mg | IRRIGATION | NDA | 12 sections |
| acetic acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-222 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | NDA | 11 sections |
| acetic acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0351 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | NDA | 10 sections |
| acetic acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0351 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | NDA | 10 sections |
| Acetic Acid | Human Prescription Drug Label | 1 | 50090-6263 | SOLUTION | 20 mg | AURICULAR (OTIC) | ANDA | 12 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-6527 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | ANDA | 12 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50383-889 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | NDA | 10 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50383-889 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | NDA | 10 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50383-889 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | NDA | 10 sections |
| hydrocortisone and acetic acid | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50383-901 | SOLUTION | 20.75 mg | AURICULAR (OTIC) | NDA | 13 sections |
| hydrocortisone and acetic acid | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50383-901 | SOLUTION | 20.75 mg | AURICULAR (OTIC) | NDA | 13 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-4600 | SOLUTION | 20 mg | AURICULAR (OTIC) | ANDA | 11 sections |
| Hydrocortisone and Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 2 | 51672-3007 | SOLUTION | 20.80 mg | AURICULAR (OTIC) | ANDA | 13 sections |
| RELEGARD | HUMAN PRESCRIPTION DRUG LABEL | 2 | 51674-0130 | GEL | 0.90 mg | TOPICAL | unapproved drug other | 3 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52817-816 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | ANDA | 12 sections |
| acetic acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55045-1243 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | NDA | 11 sections |
| acetic acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55700-424 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | NDA | 11 sections |
| acetic acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55700-424 | SOLUTION | 20.65 mg | AURICULAR (OTIC) | NDA | 11 sections |
| Fever Reliever | HUMAN OTC DRUG LABEL | 16 | 57955-0160 | LIQUID | 10 [hp_X] | ORAL | unapproved homeopathic | 9 sections |
| ACETIC ACID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60432-741 | SOLUTION | 20 mg | AURICULAR (OTIC) | ANDA | 11 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64980-424 | SOLUTION | 20 mg | AURICULAR (OTIC) | ANDA | 12 sections |
| Acetic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64980-424 | SOLUTION | 20 mg | AURICULAR (OTIC) | ANDA | 12 sections |