chlortetracycline ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, protein-synthesis inhibitors, tetracycline derivatives 624 57-62-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chlortetracycline
  • aureociclin
  • aureomicina
  • aureomycin
  • chlorocyclinum
  • chlortetracyclin
  • chlortetracycline hydrochloride
  • chlortetracycline HCl
  • chlortetracycline calcium complex
  • chlortetracycline calcium
  • chlortetracycline bisulfate
A TETRACYCLINE with a 7-chloro substitution.
  • Molecular weight: 478.88
  • Formula: C22H23ClN2O8
  • CLOGP: -0.49
  • LIPINSKI: 1
  • HAC: 10
  • HDO: 6
  • TPSA: 181.62
  • ALOGS: -3.27
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 59.66 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 30 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.52 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 23, 1950 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Adulterated product 36.83 31.56 3 4 25 29574495

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AB21 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Antiinfectives and antiseptics for local oral treatment
ATC D06AA02 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Tetracycline and derivatives
ATC J01AA03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
TETRACYCLINES
Tetracyclines
ATC S01AA02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
CHEBI has role CHEBI:22986 calcium ionophores
CHEBI has role CHEBI:35820 antiprotozoal drugs
CHEBI has role CHEBI:36047 antibacterial drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Trachoma indication 2576002 DOID:11265
Neonatal conjunctivitis indication 34298002 DOID:9699
Minor Bacterial Skin Infections indication
Blepharoconjunctivitis off-label use 68659002 DOID:2456
Bacterial conjunctivitis off-label use 128350005 DOID:9700
Ocular rosacea off-label use 200933006
Meibomianitis off-label use 309779001
Infective blepharitis off-label use 312219000
Bacterial keratitis off-label use 314557000




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cattle Maintenance of weight gains in the presence of respiratory disease Indication
Cattle Bacterial enteritis caused by Escherichia coli Indication
Cattle Bacterial enteritis caused by Salmonella spp Indication
Cattle Bacterial pneumonia caused by Pasteurella spp Indication
Cattle Bacterial pneumonia caused by Histophilus spp Indication
Cattle Bacterial pneumonia caused by Klebsiella spp Indication
Cattle To reduce the incidence of liver abscesses Indication
Cattle Anaplasmosis caused by Anaplasma marginale Indication
Chickens Infectious synovitis caused by Mycoplasma synoviae Indication
Chickens Escherichia coli infections Indication
Chickens Prevention of coccidiosis caused by Eimeria tenella Indication
Chickens Prevention of coccidiosis caused by E necatrix Indication
Chickens Prevention of coccidiosis caused by E acervulina Indication
Chickens Prevention of coccidiosis caused by E maxima Indication
Chickens Prevention of coccidiosis caused by E brunetti Indication
Chickens Prevention of coccidiosis caused by E mivati Indication
Chickens Chronic respiratory disease caused by Mycoplasma gallisepticum Indication
Chickens Chronic respiratory disease caused by Escherichia coli Indication
Ducks Cholera caused by Pasteurella multocida Indication
Psittacine Birds Psittacosis caused by Chlamydia psittaci Indication
Sheep Reducing the incidence of (vibrionic) abortion caused by Campylobacter fetus infection Indication
Swine Reduction of the incidence of cervical abscesses Indication
Swine Bacterial swine enteritis Indication
Swine Maintenance of weight gains in the presence of atrophic rhinitis Indication
Swine Bacterial pneumonia caused by Pasteurella multocida Indication
Swine Reduction in the incidence of cervical lymphadenitis (jowl abscesses) caused by group E Streptococci Indication
Swine Proliferative enteropathies (ileitis) caused by Lawsonia intracellularis Indication
Swine Leptospirosis caused by Leptospira pomona Indication
Swine Reducing the incidence of (vibrionic) abortion caused by Campylobacter fetus infection Indication
Turkeys Infectious synovitis caused by Mycoplasma Indication
Turkeys Hexamitiasis caused by Hexamita meleagridis Indication
Turkeys Control of complicating bacterial organisms associated with bluecomb Indication
Turkeys Reduction of mortality caused by paratyphoid caused by Salmonella typhimurium Indication
Cattle Maintenance of weight gains in the presence of respiratory disease Indication
Cattle Bacterial enteritis caused by Escherichia coli Indication
Cattle Bacterial enteritis caused by Salmonella spp Indication
Cattle Bacterial pneumonia caused by Pasteurella spp Indication
Cattle Bacterial pneumonia caused by Histophilus spp Indication
Cattle Bacterial pneumonia caused by Klebsiella spp Indication
Cattle Reduction of the incidence of liver abscesses Indication
Cattle Anaplasmosis caused by Anaplasma marginale Indication
Chickens Infectious synovitis caused by Mycoplasma synoviae Indication
Chickens Reduction of mortality caused by Escherichia coli infections Indication
Chickens Prevention of coccidiosis caused by Eimeria tenella Indication
Chickens Prevention of coccidiosis caused by E necatrix Indication
Chickens Prevention of coccidiosis caused by E acervulina Indication
Chickens Prevention of coccidiosis caused by E maxima Indication
Chickens Prevention of coccidiosis caused by E brunetti Indication
Chickens Prevention of coccidiosis caused by E mivati Indication
Chickens Chronic respiratory disease caused by Mycoplasma gallisepticum Indication
Chickens Chronic respiratory disease caused by Escherichia coli Indication
Ducks Cholera caused by Pasteurella multocida Indication
Psittacine Birds Psittacosis caused by Chlamydia psittaci Indication
Sheep Reducing the incidence of (vibrionic) abortion caused by Campylobacter fetus infection Indication
Swine Reduction of the incidence of cervical abscesses Indication
Swine Bacterial swine enteritis Indication
Swine Maintenance of weight gains in the presence of atrophic rhinitis Indication
Swine Bacterial pneumonia caused by Pasteurella multocida Indication
Swine Reduction in the incidence of cervical lymphadenitis (jowl abscesses) caused by group E Streptococci Indication
Swine Proliferative enteropathies (ileitis) caused by Lawsonia intracellularis Indication
Swine Leptospirosis caused by Leptospira pomona Indication
Swine Reducing the incidence of (vibrionic) abortion caused by Campylobacter fetus infection Indication
Turkeys Infectious synovitis caused by Mycoplasma Indication
Turkeys Hexamitiasis caused by Hexamita meleagridis Indication
Turkeys Control of complicating bacterial organisms associated with bluecomb Indication
Turkeys Reduction of mortality caused by paratyphoid caused by Salmonella typhimurium Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Aureomix S 40/40 Granular Zoetis Inc. 2
Aureo S 700 Granular, Aureo S 700 Zoetis Inc. 2
Amprol Plus and Aureomycin Zoetis Inc. 3
AUREOMIX S 700-A Zoetis Inc. 2
AUREOMIX S 700-D Zoetis Inc. 2
Aureomix S 700-G Zoetis Inc. 2
Aureomix S 700-E Zoetis Inc. 2
Aureomix 700-F Zoetis Inc. 2
Aureomix S 700-C Zoetis Inc. 2
AUREOMIX S 700-B Zoetis Inc. 2
AUREOMIX S 700-H Zoetis Inc. 2
Deccox and Aureomycin Zoetis Inc. 2
COYDEN plus CTC Huvepharma EOOD 2
ChlorMax 50, ChlorMax 65, ChlorMax 70, ChlorMax 100, Micro CTC Zoetis Inc. 1
Chloratet 100, Chloratet 50, Chloratet 90 Pharmgate Inc. 1
Aureomycin 50 Granular, Aureomycin 50 Granular A, Aureomycin 70 Granular, Aureomycin 80 Granular, Aureomycin 90 Granular, Aureomycin 90 Meal, Aureomycin 100 Granular Zoetis Inc. 1
PfiChlor 50, PfiChlor 70, PfiChlor 100 Zoetis Inc. 1
Chloronex Sulmet Huvepharma EOOD 2
Chlortetracycline Hydrochloride Tablets Huvepharma EOOD 1
Bulk Chlortetracycline Hydrochloride Zoetis Inc. 1
Aureomycin Soluble Powder Zoetis Inc. 1
Aureomycin Soluble Oblets Huvepharma EOOD 1
CHLORTETRACYCLINE SOLUBLE POWDER Pharmgate Inc. 1
Fermycin Soluble Phibro Animal Health Corp. 1
CHLORTET-SOLUBLE-O Pharmgate Inc. 1
Chloronex Pharmgate Inc. 1
Chlortetracycline hydrochloride soluble powder Pharmgate Inc. 1
Calf Scour Boluses, Chlortetracycline Pneumonia Cronus Pharma Specialities India Private Limited 1
CTC Bisulfate Soluble Powder Cronus Pharma Specialities India Private Limited 1
CLTC 10, CLTC 20, CLTC 30, CLTC 50, CLTC 70 Phibro Animal Health Corp. 1
CLTC 50 MR, CLTC 100 MR Phibro Animal Health Corp. 1
Robenz and Aureomycin Zoetis Inc. 2
PfiChlor 100S Zoetis Inc. 1
Aureomycin / Coban Zoetis Inc. 2
Pennchlor S 40/40 Pharmgate Inc. 2
Pennchlor 50, Pennchlor 50 G, Pennchlor 90 G, Pennchlor 100 G, Pennchlor 100 Hi-Flo Pharmgate Inc. 1
Bio-Cox/Aureomycin Zoetis Inc. 2
Aureomycin and Cattlyst Zoetis Inc. 2
Denagard plus CTC Elanco US Inc. 2
BMD and ChlorMax Zoetis Inc. 2
Chlormax and Deccox Zoetis Inc. 2
Aureomycin / Deccox Zoetis Inc. 2
Aureomycin and Bovatec Zoetis Inc. 2
MGA and Aureomycin Zoetis Inc. 2
MGA and Bovatec and Aureomycin Zoetis Inc. 3
Aureo S 700 and Bovatec Zoetis Inc. 3
Aureomycin / Sacox Huvepharma EOOD 2
Chlortetracycline HCL Soluble Powder Quo Vademus LLC 1
BMD-25, -30, -40, -50, -60, or -75 / Aureomycin -50, -70, -80, -90 or -100 Zoetis Inc. 2
Bio-Cox / ChlorMax Zoetis Inc. 2
ChlorMax / Sacox Zoetis Inc. 2
ChlorMax / Coban Zoetis Inc. 2
Pennchlor 64 Pharmgate Inc. 1
Pennchlor S Pharmgate Inc. 2
Pennchlor / Coban Pharmgate Inc. 2
Pennchlor / Denagard Pharmgate Inc. 2
Pennchlor / Bio-Cox Pharmgate Inc. 2
BMD Pennchlor Pharmgate Inc. 2
Pennchlor / Deccox Pharmgate Inc. 2
Aureomycin Pharmgate Inc. 1
Deracin 50 Meal, Deracin 90 Meal, Deracin 100 Meal Pharmgate Inc. 1
Deracin plus Bovatec Pharmgate Inc. 2
Deccox plus Deracin Pharmgate Inc. 2
Denagard and Deracin Pharmgate Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.26 acidic
pKa2 6.96 acidic
pKa3 7.57 acidic
pKa4 11.92 acidic
pKa5 12.66 acidic
pKa6 13.29 acidic
pKa7 9.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Enzyme IC50 4 CHEMBL
Major prion protein Surface antigen WOMBAT-PK
Protein-arginine deiminase type-4 Enzyme IC50 4 CHEMBL

External reference:

IDSource
4019677 VUID
N0000147769 NUI
D02255 KEGG_DRUG
64-72-2 SECONDARY_CAS_RN
1306093 RXNORM
4017878 VANDF
4019677 VANDF
C0008293 UMLSCUI
CHEBI:27644 CHEBI
CTC PDB_CHEM_ID
CHEMBL404520 ChEMBL_ID
CHEMBL2146063 ChEMBL_ID
D002751 MESH_DESCRIPTOR_UI
DB09093 DRUGBANK_ID
236 INN_ID
57122-99-3 SECONDARY_CAS_RN
27823-62-7 SECONDARY_CAS_RN
WCK1KIQ23Q UNII
54675777 PUBCHEM_CID
4431 MMSL
618 MMSL
002741 NDDF
003592 NDDF
373509001 SNOMEDCT_US
57538001 SNOMEDCT_US
7737009 SNOMEDCT_US
96319006 SNOMEDCT_US
96320000 SNOMEDCT_US
CHEMBL2146100 ChEMBL_ID
CHEMBL2106006 ChEMBL_ID

Pharmaceutical products:

None