retapamulin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, pleuromulin derivatives 2371 224452-66-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • retapamulin
  • altabax
  • altargo
  • mutilin
  • retpamulin
  • SB275833
  • SB-275833
  • Molecular weight: 517.77
  • Formula: C30H47NO4S
  • CLOGP: 5.21
  • LIPINSKI: 2
  • HAC: 5
  • HDO: 1
  • TPSA: 66.84
  • ALOGS: -6.12
  • ROTB: 6

  • Status: ONP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 24, 2007 EMA
April 12, 2007 FDA GLAXO GRP LTD

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D06AX13 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
FDA CS M0006609 Diterpenes
FDA EPC N0000175434 Pleuromutilin Antibacterial
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Impetigo indication 48277006 DOID:8504
Superficial bacterial infection of skin indication 275441009
Skin irritation contraindication 367466007

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4026103 VUID
N0000179794 NUI
D05720 KEGG_DRUG
4026103 VANDF
C1872275 UMLSCUI
CHEMBL1658 ChEMBL_ID
6918462 PUBCHEM_CID
DB01256 DRUGBANK_ID
C508887 MESH_SUPPLEMENTAL_RECORD_UI
C475718 MESH_SUPPLEMENTAL_RECORD_UI
11035 IUPHAR_LIGAND_ID
8494 INN_ID
4MG6O8991R UNII
642274 RXNORM
109329 MMSL
23817 MMSL
012148 NDDF
426825005 SNOMEDCT_US
427137002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Altabax HUMAN PRESCRIPTION DRUG LABEL 1 16110-518 OINTMENT 10 mg TOPICAL NDA 26 sections
Altabax HUMAN PRESCRIPTION DRUG LABEL 1 21695-644 OINTMENT 10 mg TOPICAL NDA 18 sections
Altabax HUMAN PRESCRIPTION DRUG LABEL 1 54868-6096 OINTMENT 10 mg TOPICAL NDA 18 sections