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retapamulin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, pleuromulin derivatives | 2371 | 224452-66-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,IGF1R,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK1,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ZAP70 | 45 | |||
| kinase-selectivity-class | EIF2AK3 | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 24, 2007 | EMA | ||
| April 12, 2007 | FDA | GLAXO GRP LTD |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D06AX13 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use |
| FDA CS | M0006609 | Diterpenes |
| FDA EPC | N0000175434 | Pleuromutilin Antibacterial |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
Related Drugs by ATC class:
D06AX Other antibiotics for topical use 12 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Impetigo | indication | 48277006 | DOID:8504 |
| Superficial bacterial infection of skin | indication | 275441009 | |
| Skin irritation | contraindication | 367466007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.61 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4026103 | VUID |
| N0000179794 | NUI |
| D05720 | KEGG_DRUG |
| 6040-37-5 | SECONDARY_CAS_RN |
| 4026103 | VANDF |
| C1703334 | UMLSCUI |
| G34 | PDB_CHEM_ID |
| CHEMBL1658 | ChEMBL_ID |
| DB01256 | DRUGBANK_ID |
| C508887 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11035 | IUPHAR_LIGAND_ID |
| C475718 | MESH_SUPPLEMENTAL_RECORD_UI |
| 8494 | INN_ID |
| 4MG6O8991R | UNII |
| 6918462 | PUBCHEM_CID |
| 642274 | RXNORM |
| 109329 | MMSL |
| 23817 | MMSL |
| 012148 | NDDF |
| 426825005 | SNOMEDCT_US |
| 427137002 | SNOMEDCT_US |
| CHEBI:42737 | CHEBI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Altabax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-644 | OINTMENT | 10 mg | TOPICAL | NDA | 18 sections |
| Altabax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6096 | OINTMENT | 10 mg | TOPICAL | NDA | 18 sections |