gentamicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
aminoglycosides, antibiotics obtained from various Micromonospora 4265 1405-41-0

Description:

MoleculeDescription

Synonyms:

  • gentamicin sulfate
  • gentamicin
  • alcomicin
  • gentacin
  • gentamicine sulfate
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
  • Molecular weight: 1390.73
  • Formula: C60H123N15O21
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.24 g P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.28 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.33 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.70 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 19, 1970 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 720.70 12.42 623 22914 319764 90285146
Premature delivery 590.26 12.42 258 23279 38504 90566406
Normal labour 582.82 12.42 106 23431 511 90604399
Delivery 486.38 12.42 109 23428 1684 90603226
Drug reaction with eosinophilia and systemic symptoms 267.78 12.42 156 23381 42602 90562308
Renal tubular necrosis 251.37 12.42 106 23431 14449 90590461
Multiple organ dysfunction syndrome 205.61 12.42 158 23379 68178 90536732
Toxic epidermal necrolysis 178.42 12.42 109 23428 32419 90572491
Maternal exposure during pregnancy 167.05 12.42 319 23218 359744 90245166
Pathogen resistance 143.11 12.42 60 23477 8055 90596855
Sepsis 139.58 12.42 201 23336 179613 90425297
Septic shock 138.44 12.42 138 23399 84022 90520888
Renal failure 137.90 12.42 170 23367 130837 90474073
Peritonitis bacterial 121.49 12.42 47 23490 5124 90599786
Ototoxicity 117.78 12.42 36 23501 1928 90602982
Product use in unapproved indication 101.91 12.42 251 23286 335985 90268925
Peritonitis 92.88 12.42 60 23477 19645 90585265
Anaphylactic reaction 91.12 12.42 113 23424 87411 90517499
Bartter's syndrome 87.50 12.42 13 23524 9 90604901
Drug resistance 82.02 12.42 66 23471 30383 90574527
Toxic skin eruption 81.75 12.42 51 23486 15723 90589187
Eosinophilia 81.46 12.42 64 23473 28469 90576441
Mucosal inflammation 77.71 12.42 85 23452 57540 90547370
Abdominal discomfort 77.54 12.42 15 23522 477313 90127597
Nephropathy toxic 75.97 12.42 45 23492 12643 90592267
Joint swelling 73.43 12.42 20 23517 503280 90101630
Pyrexia 71.10 12.42 349 23188 660136 89944774
Premature baby 71.05 12.42 56 23481 25021 90579889
Antibiotic level above therapeutic 70.98 12.42 18 23519 480 90604430
Excessive eye blinking 69.07 12.42 22 23515 1350 90603560
Drug intolerance 68.73 12.42 16 23521 447575 90157335
Renal impairment 62.31 12.42 104 23433 105317 90499593
Shock haemorrhagic 61.97 12.42 39 23498 12206 90592704
Oliguria 61.84 12.42 37 23500 10587 90594323
Neutropenic sepsis 61.32 12.42 45 23492 18085 90586825
Synovitis 61.24 12.42 7 23530 329745 90275165
Drug interaction 61.23 12.42 184 23353 276269 90328641
Pemphigus 60.55 12.42 7 23530 326857 90278053
Tubulointerstitial nephritis 60.05 12.42 51 23486 25292 90579618
Systemic lupus erythematosus 59.54 12.42 11 23526 361885 90243025
Candida infection 58.10 12.42 57 23480 34000 90570910
Stevens-Johnson syndrome 57.40 12.42 53 23484 29323 90575587
Glossodynia 56.92 12.42 8 23529 321771 90283139
Foetal exposure during pregnancy 55.53 12.42 62 23475 42913 90561997
Vestibular disorder 54.66 12.42 19 23518 1530 90603380
Nasopharyngitis 54.28 12.42 19 23518 407085 90197825
Hand deformity 53.29 12.42 7 23530 296355 90308555
Headache 53.28 12.42 89 23448 862657 89742253
Rheumatoid arthritis 51.75 12.42 15 23522 362599 90242311
Arthropathy 50.73 12.42 16 23521 366226 90238684
Endocarditis 49.98 12.42 28 23509 7085 90597825
Weight increased 48.47 12.42 24 23513 417903 90187007
Persistent genital arousal disorder 47.00 12.42 14 23523 686 90604224
Oropharyngeal oedema 46.09 12.42 12 23525 356 90604554
Metabolic alkalosis 45.58 12.42 21 23516 3528 90601382
Infusion related reaction 45.30 12.42 26 23511 416754 90188156
Fatigue 44.30 12.42 153 23384 1153870 89451040
Gastrointestinal disorder 43.96 12.42 7 23530 256680 90348230
Haemodynamic instability 43.96 12.42 31 23506 11708 90593202
Renal injury 42.95 12.42 29 23508 10214 90594696
Escherichia infection 41.84 12.42 34 23503 15861 90589049
Arthritis bacterial 40.93 12.42 25 23512 7420 90597490
Umbilical erythema 39.65 12.42 8 23529 72 90604838
Intraventricular haemorrhage neonatal 39.64 12.42 10 23527 261 90604649
Anti-cyclic citrullinated peptide antibody positive 39.27 12.42 7 23530 236426 90368484
Enterococcal infection 38.85 12.42 27 23510 9964 90594946
Pancytopenia 38.70 12.42 92 23445 120171 90484739
Type 2 diabetes mellitus 38.52 12.42 4 23533 203240 90401670
Hepatic enzyme increased 38.49 12.42 23 23514 360713 90244197
Anuria 37.54 12.42 31 23506 14787 90590123
Mental status changes postoperative 37.54 12.42 9 23528 189 90604721
Acute generalised exanthematous pustulosis 37.53 12.42 30 23507 13673 90591237
Abscess neck 37.48 12.42 12 23525 749 90604161
Linear IgA disease 37.38 12.42 16 23521 2258 90602652
Liver abscess 36.68 12.42 18 23519 3478 90601432
Disseminated intravascular coagulation 36.64 12.42 36 23501 21502 90583408
Hyperchlorhydria 36.40 12.42 15 23522 1926 90602984
Fall 36.34 12.42 43 23494 481767 90123143
Pain 36.25 12.42 135 23402 996206 89608704
Contraindicated product administered 36.18 12.42 19 23518 320120 90284790
Musculoskeletal stiffness 35.95 12.42 16 23521 296516 90308394
Duodenal ulcer perforation 35.79 12.42 7 23530 221281 90383629
Necrotising enterocolitis neonatal 35.60 12.42 9 23528 237 90604673
Confusion postoperative 35.42 12.42 9 23528 242 90604668
Renal tubular disorder 35.11 12.42 17 23520 3190 90601720
Neutropenia 34.97 12.42 133 23404 224771 90380139
Sepsis syndrome 34.58 12.42 12 23525 961 90603949
Fibromyalgia 34.48 12.42 6 23531 206263 90398647
Peripheral swelling 34.33 12.42 34 23503 413072 90191838
Noninfectious peritonitis 34.28 12.42 8 23529 149 90604761
Disturbance in sexual arousal 34.07 12.42 9 23528 283 90604627
Pericarditis 33.66 12.42 14 23523 270137 90334773
Tonsillitis bacterial 33.28 12.42 8 23529 170 90604740
Cholestasis 33.24 12.42 44 23493 36255 90568655
Swelling 33.12 12.42 36 23501 419022 90185888
Tendon necrosis 32.82 12.42 5 23532 5 90604905
Deafness neurosensory 32.65 12.42 21 23516 6820 90598090
Crystalluria 32.42 12.42 10 23527 552 90604358
Therapeutic product effect decreased 32.07 12.42 16 23521 277555 90327355
Perineal pain 32.06 12.42 10 23527 573 90604337
Blood creatinine increased 32.01 12.42 77 23460 101309 90503601
Skin test positive 31.60 12.42 11 23526 889 90604021
Sepsis neonatal 31.56 12.42 10 23527 603 90604307
Psoriatic arthropathy 31.55 12.42 10 23527 228325 90376585
Acute respiratory distress syndrome 31.39 12.42 38 23499 28648 90576262
Thrombocytopenia 31.27 12.42 122 23415 208603 90396307
Staphylococcal sepsis 31.08 12.42 23 23514 9360 90595550
Intentional product use issue 30.87 12.42 9 23528 216883 90388027
Skin lesion 30.74 12.42 43 23494 37322 90567588
Gastrointestinal haemorrhage 30.07 12.42 70 23467 90178 90514732
Wound 30.02 12.42 21 23516 302959 90301951
Discomfort 29.95 12.42 17 23520 274318 90330592
Folate deficiency 29.39 12.42 15 23522 3150 90601760
Guillain-Barre syndrome 29.30 12.42 17 23520 4595 90600315
Clostridial infection 29.22 12.42 17 23520 4619 90600291
Rash erythematous 29.21 12.42 57 23480 65047 90539863
Rash maculo-papular 29.15 12.42 44 23493 40889 90564021
Pain in extremity 29.12 12.42 45 23492 450484 90154426
Renal cortical necrosis 29.05 12.42 8 23529 295 90604615
Blood cholesterol increased 28.94 12.42 9 23528 208003 90396907
Migraine 28.80 12.42 7 23530 190385 90414525
Retinal infarction 28.56 12.42 6 23531 67 90604843
Procedural hypertension 28.19 12.42 8 23529 330 90604580
Coagulation time prolonged 28.14 12.42 12 23525 1678 90603232
Hypopyon 27.65 12.42 10 23527 904 90604006
Female reproductive tract disorder 27.15 12.42 9 23528 627 90604283
Endocarditis bacterial 27.02 12.42 9 23528 636 90604274
Inflammatory marker increased 27.01 12.42 21 23516 9193 90595717
Anaphylactic shock 26.93 12.42 37 23500 31580 90573330
Tachycardia 26.81 12.42 96 23441 157577 90447333
Septic embolus 26.80 12.42 10 23527 987 90603923
Polyglandular disorder 26.29 12.42 7 23530 227 90604683
Staphylococcal infection 26.24 12.42 46 23491 48393 90556517
Hypotension 26.12 12.42 159 23378 325238 90279672
Mycobacterium abscessus infection 26.07 12.42 10 23527 1065 90603845
Necrosis 26.02 12.42 18 23519 6592 90598318
Ejection fraction decreased 25.87 12.42 33 23504 26220 90578690
Muscle injury 25.75 12.42 7 23530 176647 90428263
Lemierre syndrome 25.74 12.42 6 23531 111 90604799
Puerperal pyrexia 25.65 12.42 5 23532 37 90604873
Hypoglossal nerve paresis 25.64 12.42 6 23531 113 90604797
Genital pain 25.60 12.42 9 23528 749 90604161
Arthralgia 25.41 12.42 110 23427 778412 89826498
Blood phosphorus decreased 25.39 12.42 16 23521 5018 90599892
Sleep disorder 25.09 12.42 10 23527 198020 90406890
Asthma 25.04 12.42 16 23521 242144 90362766
Morganella infection 24.95 12.42 9 23528 807 90604103
Lactic acidosis 24.89 12.42 46 23491 50417 90554493
Rheumatoid factor positive 24.65 12.42 7 23530 171643 90433267
Neurotoxicity 24.41 12.42 29 23508 21438 90583472
Low birth weight baby 24.39 12.42 20 23517 9447 90595463
Muscle spasms 24.24 12.42 18 23519 251865 90353045
Therapeutic product effect incomplete 24.23 12.42 10 23527 193886 90411024
Product dose omission issue 24.22 12.42 24 23513 291663 90313247
Peritoneal dialysis complication 24.21 12.42 10 23527 1292 90603618
Drug eruption 23.72 12.42 37 23500 35370 90569540
Memory impairment 23.34 12.42 11 23526 197233 90407677
Folliculitis 23.27 12.42 12 23525 204341 90400569
Human herpesvirus 6 infection reactivation 23.23 12.42 8 23529 626 90604284
Device related infection 23.21 12.42 31 23506 25755 90579155
Application site scab 22.85 12.42 6 23531 184 90604726
Insomnia 22.81 12.42 32 23505 333442 90271468
Gastrointestinal bacterial infection 22.50 12.42 9 23528 1071 90603839
Irritable bowel syndrome 22.43 12.42 13 23524 207435 90397475
Vascular device infection 22.26 12.42 21 23516 11931 90592979
Impaired healing 22.19 12.42 17 23520 234182 90370728
Purpura 22.03 12.42 23 23514 14755 90590155
Shock 22.03 12.42 32 23505 28746 90576164
Seizure 21.87 12.42 88 23449 152541 90452369
Bursitis 21.63 12.42 4 23533 131650 90473260
Malaise 21.50 12.42 79 23458 585907 90019003
Endophthalmitis 21.42 12.42 14 23523 4671 90600239
Hypoperfusion 21.18 12.42 10 23527 1774 90603136
Corneal epithelial microcysts 21.11 12.42 4 23533 25 90604885
Drug ineffective 20.99 12.42 488 23049 1383810 89221100
Haemolytic anaemia 20.74 12.42 20 23517 11677 90593233
Macroglossia 20.68 12.42 8 23529 871 90604039
Necrotising colitis 20.64 12.42 9 23528 1329 90603581
Rheumatic fever 20.63 12.42 7 23530 153114 90451796
Immune reconstitution inflammatory syndrome 20.58 12.42 16 23521 7003 90597907
Anaemia folate deficiency 20.44 12.42 7 23530 539 90604371
Kussmaul respiration 20.36 12.42 6 23531 283 90604627
Aspergillus infection 20.13 12.42 19 23518 10804 90594106
Toxic shock syndrome streptococcal 20.03 12.42 6 23531 300 90604610
Drug level increased 19.99 12.42 30 23507 27732 90577178
Neonatal respiratory failure 19.76 12.42 6 23531 314 90604596
Brain abscess 19.57 12.42 11 23526 2801 90602109
Haemodialysis 19.49 12.42 17 23520 8730 90596180
Death neonatal 19.35 12.42 10 23527 2155 90602755
Dermatitis exfoliative 19.31 12.42 14 23523 5522 90599388
Nausea 19.30 12.42 190 23347 1110126 89494784
Spinal subdural haematoma 19.18 12.42 5 23532 149 90604761
Petechiae 19.12 12.42 22 23515 15719 90589191
Osteoarthritis 18.81 12.42 14 23523 195716 90409194
Hypoaesthesia 18.78 12.42 33 23504 314177 90290733
Stridor 18.75 12.42 13 23524 4780 90600130
Alopecia 18.65 12.42 66 23471 495005 90109905
Skin oedema 18.58 12.42 8 23529 1146 90603764
Neonatal respiratory distress syndrome 18.57 12.42 11 23526 3090 90601820
Haematoma 18.51 12.42 35 23502 39013 90565897
Depression 18.48 12.42 31 23506 300570 90304340
Amnesia 18.47 12.42 3 23534 108502 90496408
Pseudomonas infection 18.44 12.42 21 23516 14844 90590066
Rash morbilliform 18.32 12.42 12 23525 4017 90600893
Exfoliative rash 18.27 12.42 11 23526 3181 90601729
Mobility decreased 18.22 12.42 23 23514 250711 90354199
Gingival swelling 18.22 12.42 13 23524 5000 90599910
Congenital herpes simplex infection 18.16 12.42 3 23534 7 90604903
Musculoskeletal pain 18.13 12.42 11 23526 171240 90433670
Rash macular 18.04 12.42 30 23507 30250 90574660
Dry mouth 17.90 12.42 13 23524 184046 90420864
Clostridium difficile infection 17.82 12.42 33 23504 36212 90568698
Malnutrition 17.77 12.42 23 23514 18535 90586375
Hypocalcaemia 17.69 12.42 36 23501 42332 90562578
Anal ulcer 17.67 12.42 7 23530 812 90604098
Corneal oedema 17.62 12.42 9 23528 1892 90603018
Umbilical cord around neck 17.58 12.42 5 23532 208 90604702
Human herpesvirus 6 infection 17.54 12.42 11 23526 3421 90601489
Congenital hydrocephalus 17.48 12.42 5 23532 212 90604698
Foetal heart rate decreased 17.46 12.42 5 23532 213 90604697
Agranulocytosis 17.37 12.42 32 23505 34970 90569940
Metabolic acidosis 17.26 12.42 42 23495 55634 90549276
Injection site pain 17.24 12.42 12 23525 173687 90431223
Stomatitis 17.19 12.42 28 23509 274670 90330240
Sinusitis 17.12 12.42 40 23497 343048 90261862
Respiratory disorder neonatal 17.09 12.42 8 23529 1393 90603517
Hypotensive crisis 17.06 12.42 4 23533 76 90604834
Asthenia 17.03 12.42 76 23461 533675 90071235
Joint range of motion decreased 16.93 12.42 7 23530 135636 90469274
Hepatic failure 16.88 12.42 34 23503 39694 90565216
Urogenital disorder 16.87 12.42 4 23533 80 90604830
Endocrine disorder 16.60 12.42 7 23530 953 90603957
Systemic infection 16.48 12.42 12 23525 4763 90600147
Neonatal cardiac failure 16.40 12.42 3 23534 15 90604895
Hypervolaemia 16.33 12.42 30 23507 32727 90572183
Hypoparathyroidism 16.31 12.42 7 23530 994 90603916
Contusion 16.30 12.42 25 23512 251191 90353719
Infusion site necrosis 16.22 12.42 4 23533 95 90604815
Disease progression 16.20 12.42 82 23455 156533 90448377
Neonatal disorder 16.14 12.42 6 23531 586 90604324
Pseudo-Bartter syndrome 16.14 12.42 4 23533 97 90604813
Weight decreased 16.14 12.42 48 23489 379862 90225048
Bacterial sepsis 16.08 12.42 12 23525 4943 90599967
Candida test positive 16.06 12.42 7 23530 1032 90603878
Arthritis 16.03 12.42 12 23525 167303 90437607
Hydrops foetalis 15.94 12.42 6 23531 607 90604303
Corneal perforation 15.94 12.42 6 23531 607 90604303
Geotrichum infection 15.91 12.42 6 23531 610 90604300
Gait disturbance 15.89 12.42 27 23510 260469 90344441
Blood culture positive 15.83 12.42 12 23525 5060 90599850
Dialysis 15.77 12.42 17 23520 11312 90593598
Blood alkaline phosphatase increased 15.69 12.42 37 23500 48042 90556868
Hypotonia 15.65 12.42 17 23520 11409 90593501
Abdominal pain upper 15.64 12.42 40 23497 332634 90272276
Pancreatitis haemorrhagic 15.60 12.42 6 23531 643 90604267
Skin bacterial infection 15.59 12.42 6 23531 645 90604265
Meconium in amniotic fluid 15.51 12.42 5 23532 319 90604591
Sleep disorder due to general medical condition, insomnia type 15.49 12.42 7 23530 128687 90476223
Loss of personal independence in daily activities 15.48 12.42 8 23529 136097 90468813
Chronic hepatitis 15.41 12.42 7 23530 1138 90603772
Inappropriate schedule of product administration 15.36 12.42 10 23527 149923 90454987
Fungaemia 15.29 12.42 10 23527 3340 90601570
Hypertension 15.29 12.42 64 23473 457468 90147442
Therapeutic drug monitoring analysis incorrectly performed 15.26 12.42 5 23532 336 90604574
Odynophagia 15.17 12.42 15 23522 9028 90595882
Epstein-Barr virus test positive 15.15 12.42 6 23531 695 90604215
Nephrocalcinosis 14.92 12.42 7 23530 1225 90603685
Neuromuscular blockade 14.91 12.42 5 23532 361 90604549
Lethargy 14.87 12.42 43 23494 63096 90541814
Corneal deposits 14.73 12.42 5 23532 375 90604535
Oscillopsia 14.70 12.42 4 23533 141 90604769
Anaemia 14.66 12.42 148 23389 352654 90252256
Product used for unknown indication 14.63 12.42 6 23531 761 90604149
Bacteraemia 14.52 12.42 23 23514 22277 90582633
Electrocardiogram T wave inversion 14.43 12.42 10 23527 3673 90601237
Blood creatine phosphokinase increased 14.31 12.42 29 23508 33994 90570916
Urine output decreased 14.28 12.42 17 23520 12586 90592324
Clostridium colitis 14.23 12.42 8 23529 2037 90602873
Amniotic cavity infection 14.09 12.42 7 23530 1389 90603521
Wound infection fungal 14.02 12.42 4 23533 168 90604742
Paraparesis 13.97 12.42 9 23528 2929 90601981
Bronchopulmonary aspergillosis 13.96 12.42 16 23521 11382 90593528
Hypotonia neonatal 13.93 12.42 7 23530 1423 90603487
Obesity 13.91 12.42 5 23532 105502 90499408
Skin infection 13.87 12.42 20 23517 17844 90587066
Atrial fibrillation 13.85 12.42 70 23467 133541 90471369
Pulmonary necrosis 13.80 12.42 4 23533 178 90604732
Abdominal sepsis 13.79 12.42 7 23530 1452 90603458
Hyperleukocytosis 13.79 12.42 6 23531 881 90604029
C-reactive protein abnormal 13.75 12.42 8 23529 127421 90477489
Oesophagitis haemorrhagic 13.58 12.42 5 23532 475 90604435
Dyssomnia 13.40 12.42 3 23534 46 90604864
Conjunctival hyperaemia 13.35 12.42 9 23528 3160 90601750
Sudden visual loss 13.17 12.42 3 23534 50 90604860
Erythema 13.04 12.42 103 23434 229143 90375767
Aortic valve incompetence 13.03 12.42 12 23525 6612 90598298
Deafness 13.01 12.42 22 23515 22492 90582418
Skin exfoliation 12.97 12.42 43 23494 67870 90537040
Respiratory failure 12.95 12.42 63 23474 118355 90486555
Neonatal anuria 12.95 12.42 3 23534 54 90604856
Staphylococcus test positive 12.95 12.42 10 23527 4335 90600575
Apnoea 12.88 12.42 14 23523 9400 90595510
Toxic shock syndrome 12.85 12.42 6 23531 1038 90603872
Skin erosion 12.82 12.42 9 23528 3373 90601537
Paraplegia 12.75 12.42 9 23528 3403 90601507
Pulmonary haemorrhage neonatal 12.75 12.42 3 23534 58 90604852
Nasal congestion 12.74 12.42 3 23534 83411 90521499
Deafness bilateral 12.74 12.42 7 23530 1706 90603204
Renal impairment neonatal 12.70 12.42 3 23534 59 90604851
Stenotrophomonas infection 12.66 12.42 8 23529 2521 90602389
Night sweats 12.64 12.42 9 23528 128757 90476153
Paraesthesia 12.63 12.42 29 23508 250297 90354613
Potentiating drug interaction 12.61 12.42 11 23526 5651 90599259
Bradycardia neonatal 12.59 12.42 6 23531 1087 90603823
Tetany 12.50 12.42 8 23529 2576 90602334
Face oedema 12.44 12.42 22 23515 23296 90581614
Immune effector cell-associated neurotoxicity syndrome 12.43 12.42 11 23526 5757 90599153

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 556.94 14.70 860 24039 366477 42229959
Drug reaction with eosinophilia and systemic symptoms 255.06 14.70 205 24694 41870 42554566
Pathogen resistance 227.62 14.70 118 24781 11332 42585104
Renal tubular necrosis 157.02 14.70 110 24789 18244 42578192
Delusion of grandeur 139.13 14.70 50 24849 1946 42594490
Ototoxicity 135.32 14.70 51 24848 2274 42594162
Eosinophilia 128.49 14.70 125 24774 32774 42563662
Nephropathy toxic 123.66 14.70 92 24807 16746 42579690
Drug resistance 118.78 14.70 122 24777 34126 42562310
Rhinalgia 116.65 14.70 43 24856 1801 42594635
Lymphocyte count abnormal 106.00 14.70 42 24857 2145 42594291
Affective disorder 97.57 14.70 54 24845 5906 42590530
Multiple organ dysfunction syndrome 92.03 14.70 186 24713 96849 42499587
Rash maculo-papular 89.56 14.70 110 24789 37393 42559043
Crystalluria 88.86 14.70 28 24871 722 42595714
Septic shock 84.88 14.70 174 24725 91498 42504938
Endocarditis 84.38 14.70 55 24844 8097 42588339
Spinal muscular atrophy 77.38 14.70 22 24877 394 42596042
Acute generalised exanthematous pustulosis 76.97 14.70 53 24846 8542 42587894
Peritonitis bacterial 74.88 14.70 48 24851 6867 42589569
Toxic skin eruption 68.81 14.70 60 24839 13670 42582766
Schizophrenia 67.25 14.70 53 24846 10497 42585939
Renal failure 64.05 14.70 207 24692 143519 42452917
Drug ineffective 61.81 14.70 599 24300 629598 41966838
Product dose omission issue 60.57 14.70 9 24890 154356 42442080
Pneumococcal sepsis 60.40 14.70 25 24874 1430 42595006
Pyrexia 59.87 14.70 414 24485 393628 42202808
Anaphylactic reaction 59.71 14.70 97 24802 42646 42553790
Red blood cell hyperchromic morphology 57.54 14.70 10 24889 10 42596426
Premature baby 57.02 14.70 69 24830 23084 42573352
Death 56.96 14.70 119 24780 471066 42125370
SARS-CoV-2 test positive 55.91 14.70 43 24856 8217 42588219
Fall 55.83 14.70 34 24865 234486 42361950
Asthenia 54.90 14.70 50 24849 280743 42315693
Tubulointerstitial nephritis 53.03 14.70 78 24821 31470 42564966
Lymphocyte count decreased 53.00 14.70 73 24826 27736 42568700
Extrapyramidal disorder 52.46 14.70 56 24843 16356 42580080
Motor neurone disease 50.52 14.70 17 24882 542 42595894
Neutrophil count increased 50.38 14.70 60 24839 19744 42576692
Toxic epidermal necrolysis 49.16 14.70 69 24830 26681 42569755
Increased bronchial secretion 48.97 14.70 25 24874 2321 42594115
Renal impairment 48.39 14.70 158 24741 110070 42486366
Peritonitis 48.30 14.70 57 24842 18576 42577860
Vestibular disorder 48.10 14.70 20 24879 1157 42595279
Dizziness 47.97 14.70 45 24854 249209 42347227
Stoma closure 47.14 14.70 14 24885 294 42596142
Hallucination, auditory 46.25 14.70 50 24849 14814 42581622
Leukopenia 45.09 14.70 120 24779 74626 42521810
Cardiac valve vegetation 43.22 14.70 15 24884 526 42595910
Deafness neurosensory 43.04 14.70 27 24872 3719 42592717
Necrotising colitis 42.79 14.70 19 24880 1292 42595144
Linear IgA disease 42.71 14.70 22 24877 2081 42594355
Purpura 42.40 14.70 43 24856 11836 42584600
Klebsiella infection 42.24 14.70 42 24857 11290 42585146
Sputum increased 41.98 14.70 25 24874 3138 42593298
Completed suicide 41.83 14.70 4 24895 96461 42499975
Respiratory tract infection bacterial 41.77 14.70 21 24878 1888 42594548
Ischaemic cerebral infarction 41.70 14.70 20 24879 1623 42594813
Neonatal disorder 40.87 14.70 16 24883 791 42595645
Aminoaciduria 40.41 14.70 12 24887 252 42596184
Fatigue 40.25 14.70 126 24773 435515 42160921
Congenital multiplex arthrogryposis 40.01 14.70 12 24887 261 42596175
Antimicrobial susceptibility test resistant 39.61 14.70 13 24886 383 42596053
Cerebral palsy 39.51 14.70 13 24886 386 42596050
Lower respiratory tract infection bacterial 38.82 14.70 14 24885 550 42595886
Auditory neuropathy spectrum disorder 38.68 14.70 6 24893 0 42596436
Bacillus infection 38.52 14.70 15 24884 731 42595705
Bronchial disorder 38.49 14.70 18 24881 1380 42595056
Chest X-ray abnormal 38.49 14.70 27 24872 4481 42591955
Fungal peritonitis 38.42 14.70 16 24883 929 42595507
Neonatal candida infection 38.14 14.70 8 24891 35 42596401
Cerebral ischaemia 38.10 14.70 32 24867 6927 42589509
Disease complication 37.48 14.70 23 24876 3047 42593389
Candida infection 37.14 14.70 54 24845 21556 42574880
Resuscitation 36.80 14.70 19 24880 1806 42594630
Lymphadenectomy 36.59 14.70 13 24886 489 42595947
Psychotic disorder 36.40 14.70 63 24836 29145 42567291
Neonatal respiratory distress syndrome 36.15 14.70 26 24873 4487 42591949
Arthralgia 36.12 14.70 40 24859 205198 42391238
Neonatal hypoxia 35.20 14.70 13 24886 547 42595889
Antibiotic level above therapeutic 34.90 14.70 12 24887 409 42596027
Pulmonary haemorrhage 34.87 14.70 38 24861 11359 42585077
Hepatocellular injury 34.78 14.70 55 24844 23623 42572813
Metabolic disorder 34.78 14.70 26 24873 4762 42591674
Headache 34.61 14.70 54 24845 239315 42357121
Drug intolerance 33.17 14.70 4 24895 80420 42516016
Intraventricular haemorrhage neonatal 32.39 14.70 11 24888 361 42596075
Listeriosis 32.28 14.70 16 24883 1395 42595041
Lung consolidation 31.10 14.70 28 24871 6649 42589787
Cholestasis 29.90 14.70 62 24837 32817 42563619
Insomnia 29.74 14.70 16 24883 118237 42478199
Brain injury 29.70 14.70 29 24870 7626 42588810
Conductive deafness 28.85 14.70 11 24888 506 42595930
Inappropriate schedule of product administration 28.84 14.70 10 24889 95892 42500544
Haematopoietic stem cell mobilisation 28.78 14.70 10 24889 352 42596084
Foetal exposure during pregnancy 28.56 14.70 76 24823 47235 42549201
Pain 28.51 14.70 63 24836 244785 42351651
Nutritional condition abnormal 28.47 14.70 11 24888 525 42595911
Low birth weight baby 28.40 14.70 32 24867 9923 42586513
Acinetobacter infection 28.19 14.70 15 24884 1516 42594920
Peripheral blood stem cell apheresis 27.89 14.70 8 24891 148 42596288
Cough 27.86 14.70 38 24861 178065 42418371
Endocarditis candida 27.86 14.70 7 24892 76 42596360
Scoliosis 27.33 14.70 19 24880 3107 42593329
Metabolic acidosis 27.06 14.70 79 24820 51779 42544657
Clostridium difficile colitis 26.69 14.70 46 24853 21206 42575230
Oliguria 26.67 14.70 30 24869 9283 42587153
Symmetrical drug-related intertriginous and flexural exanthema 26.48 14.70 12 24887 856 42595580
Aspergillus infection 26.38 14.70 39 24860 15798 42580638
Nosocomial infection 26.25 14.70 14 24885 1422 42595014
Hypoprothrombinaemia 26.10 14.70 10 24889 466 42595970
Cellulitis 25.85 14.70 87 24812 61498 42534938
Agranulocytosis 25.84 14.70 56 24843 30556 42565880
Haemodynamic instability 25.49 14.70 34 24865 12523 42583913
Weight decreased 25.46 14.70 52 24847 207896 42388540
Thrombocytopenia 25.34 14.70 194 24705 190085 42406351
Red blood cell schistocytes present 25.27 14.70 9 24890 341 42596095
Demyelination 25.27 14.70 19 24880 3510 42592926
Embolia cutis medicamentosa 25.17 14.70 9 24890 345 42596091
Fungaemia 24.97 14.70 18 24881 3118 42593318
Infective keratitis 24.79 14.70 6 24893 55 42596381
Intestinal ischaemia 24.79 14.70 29 24870 9359 42587077
Sepsis 24.76 14.70 200 24699 199134 42397302
Anisocytosis 24.31 14.70 10 24889 563 42595873
Staphylococcal infection 24.29 14.70 62 24837 37581 42558855
Bradycardia neonatal 24.24 14.70 13 24886 1335 42595101
Infective aneurysm 24.20 14.70 12 24887 1047 42595389
Malignant neoplasm progression 24.01 14.70 17 24882 108383 42488053
Chronic obstructive pulmonary disease 24.01 14.70 4 24895 63110 42533326
Haemorrhage neonatal 23.55 14.70 4 24895 3 42596433
Liver abscess 23.46 14.70 21 24878 4949 42591487
Splenic abscess 22.97 14.70 10 24889 648 42595788
Alopecia 22.95 14.70 52 24847 29224 42567212
Motor dysfunction 22.92 14.70 26 24873 8120 42588316
Sepsis neonatal 22.90 14.70 8 24891 286 42596150
Pseudomembranous colitis 22.72 14.70 17 24882 3116 42593320
Pain in extremity 22.68 14.70 33 24866 150571 42445865
Encephalitis brain stem 22.57 14.70 7 24892 171 42596265
Encephalopathy 22.56 14.70 64 24835 41269 42555167
Weight increased 22.55 14.70 18 24881 107965 42488471
Acute vestibular syndrome 22.54 14.70 4 24895 5 42596431
Blood alkaline phosphatase increased 22.37 14.70 56 24843 33541 42562895
Petechiae 22.34 14.70 29 24870 10406 42586030
Scrotal pain 22.27 14.70 11 24888 952 42595484
Systemic candida 22.24 14.70 21 24878 5298 42591138
Diplegia 22.22 14.70 12 24887 1250 42595186
Epidermolysis 22.22 14.70 9 24890 487 42595949
Mucormycosis 22.17 14.70 24 24875 7119 42589317
Therapeutic product effect incomplete 22.02 14.70 7 24892 70932 42525504
Type IV hypersensitivity reaction 21.75 14.70 15 24884 2422 42594014
Depression 21.51 14.70 20 24879 111343 42485093
Lymphocyte morphology abnormal 21.29 14.70 9 24890 543 42595893
Haemodialysis 21.17 14.70 28 24871 10232 42586204
Patent ductus arteriosus 21.16 14.70 17 24882 3459 42592977
Abdominal pain upper 21.02 14.70 11 24888 82598 42513838
CNS ventriculitis 20.66 14.70 8 24891 384 42596052
Dyspnoea 20.55 14.70 163 24736 442458 42153978
Foot amputation 20.45 14.70 10 24889 847 42595589
Otitis media 20.30 14.70 17 24882 3666 42592770
Arterial angioplasty 20.27 14.70 5 24894 50 42596386
Peripheral swelling 20.20 14.70 14 24885 90256 42506180
Nasopharyngitis 20.20 14.70 12 24887 83984 42512452
Injury 20.19 14.70 42 24857 22274 42574162
Infusion site induration 20.18 14.70 8 24891 409 42596027
Hypersensitivity vasculitis 20.03 14.70 16 24883 3228 42593208
Herpes zoster reactivation 19.96 14.70 8 24891 421 42596015
Incorrect dose administered 19.78 14.70 72 24827 52902 42543534
Hypotonia 19.71 14.70 26 24873 9473 42586963
Muscle spasms 19.71 14.70 13 24886 86031 42510405
Circulatory collapse 19.67 14.70 43 24856 23593 42572843
Asthma 19.60 14.70 6 24893 62308 42534128
ADAMTS13 activity decreased 19.37 14.70 6 24893 146 42596290
Loss of personal independence in daily activities 19.30 14.70 3 24896 49813 42546623
Hyperhidrosis 19.01 14.70 15 24884 90497 42505939
CD4 lymphocytes increased 18.96 14.70 6 24893 157 42596279
Mast cell degranulation present 18.86 14.70 5 24894 68 42596368
Application site scab 18.80 14.70 5 24894 69 42596367
Jaundice cholestatic 18.71 14.70 19 24880 5234 42591202
Constipation 18.67 14.70 42 24857 162249 42434187
Aortic valve disease 18.65 14.70 11 24888 1356 42595080
Blood creatinine increased 18.64 14.70 119 24780 109884 42486552
Oculocephalogyric reflex absent 18.63 14.70 4 24895 20 42596416
Neutropenia 18.57 14.70 188 24711 199243 42397193
Joint contracture 18.47 14.70 13 24886 2168 42594268
Nausea 18.46 14.70 146 24753 396653 42199783
Respiratory distress 18.37 14.70 60 24839 41760 42554676
Necrotising enterocolitis neonatal 18.32 14.70 7 24892 324 42596112
Stenotrophomonas test positive 18.18 14.70 7 24892 331 42596105
Macrocytosis 17.95 14.70 10 24889 1107 42595329
Renal tubular disorder 17.94 14.70 18 24881 4891 42591545
Hypotension 17.75 14.70 229 24670 257402 42339034
Infective corneal ulcer 17.74 14.70 4 24895 26 42596410
Face oedema 17.71 14.70 30 24869 13636 42582800
Thrombosis 17.61 14.70 9 24890 68502 42527934
Suicide attempt 17.36 14.70 3 24896 46097 42550339
Polycythaemia 17.32 14.70 14 24885 2872 42593564
Methaemoglobinaemia 17.22 14.70 19 24880 5755 42590681
Coronary artery disease 17.21 14.70 5 24894 53715 42542721
Peritoneal cloudy effluent 17.03 14.70 7 24892 393 42596043
Opisthotonus 16.95 14.70 8 24891 626 42595810
Stevens-Johnson syndrome 16.95 14.70 39 24860 22139 42574297
Aortic valve incompetence 16.91 14.70 20 24879 6528 42589908
Diabetes mellitus 16.83 14.70 7 24892 60080 42536356
Cardiac valve abscess 16.80 14.70 4 24895 34 42596402
Myeloma cast nephropathy 16.66 14.70 5 24894 109 42596327
Cross sensitivity reaction 16.60 14.70 11 24888 1664 42594772
Chondrocalcinosis 16.59 14.70 8 24891 657 42595779
Cardiac arrest neonatal 16.50 14.70 4 24895 37 42596399
Antineutrophil cytoplasmic antibody 16.40 14.70 4 24895 38 42596398
Intentional product use issue 16.26 14.70 11 24888 71822 42524614
Stupor 16.24 14.70 14 24885 3139 42593297
Leukocytosis 16.21 14.70 46 24853 29662 42566774
Muscle atrophy 16 14.70 22 24877 8339 42588097
Condition aggravated 15.99 14.70 227 24672 260527 42335909
Disseminated mucormycosis 15.92 14.70 10 24889 1381 42595055
Wrong technique in product usage process 15.57 14.70 3 24896 42632 42553804
Anaphylactic shock 15.44 14.70 39 24860 23478 42572958
Dry gangrene 15.44 14.70 7 24892 500 42595936
Reticulocytosis 15.38 14.70 6 24893 294 42596142
Abdominal compartment syndrome 15.36 14.70 9 24890 1096 42595340
Staphylococcal bacteraemia 15.19 14.70 25 24874 11096 42585340
Cardio-respiratory arrest neonatal 15.18 14.70 3 24896 9 42596427
Jarisch-Herxheimer reaction 15.16 14.70 8 24891 795 42595641
Choriomeningitis lymphocytic 15.15 14.70 5 24894 150 42596286
Leukocyturia 15.11 14.70 8 24891 800 42595636
Eosinophilic pneumonia acute 15.03 14.70 8 24891 809 42595627
Haemophagocytic lymphohistiocytosis 14.99 14.70 33 24866 18189 42578247
Rash morbilliform 14.76 14.70 15 24884 4138 42592298
Drug level increased 14.72 14.70 41 24858 26159 42570277
Staphylococcal sepsis 14.71 14.70 25 24874 11389 42585047

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 1311.97 12.14 1380 39598 634050 109914271
Drug reaction with eosinophilia and systemic symptoms 524.45 12.14 345 40633 81750 110466571
Renal tubular necrosis 360.87 12.14 191 40787 30284 110518037
Pathogen resistance 348.62 12.14 157 40821 17515 110530806
Ototoxicity 258.05 12.14 85 40893 4046 110544275
Multiple organ dysfunction syndrome 257.64 12.14 299 40679 151411 110396910
Eosinophilia 216.05 12.14 176 40802 57760 110490561
Septic shock 208.63 12.14 274 40704 157254 110391067
Nephropathy toxic 193.80 12.14 123 40855 27355 110520966
Toxic epidermal necrolysis 192.14 12.14 163 40815 56564 110491757
Drug resistance 172.76 12.14 153 40825 56221 110492100
Renal failure 170.43 12.14 303 40675 226271 110322050
Peritonitis bacterial 165.60 12.14 80 40898 10453 110537868
Delusion of grandeur 151.26 12.14 49 40929 2211 110546110
Toxic skin eruption 145.52 12.14 103 40875 27412 110520909
Anaphylactic reaction 133.32 12.14 187 40791 114113 110434208
Rash maculo-papular 132.14 12.14 150 40828 74072 110474249
Pyrexia 131.57 12.14 668 40310 897597 109650724
Antibiotic level above therapeutic 127.98 12.14 36 40942 997 110547324
Crystalluria 126.93 12.14 38 40940 1317 110547004
Endocarditis 125.71 12.14 72 40906 13299 110535022
Lymphocyte count abnormal 120.38 12.14 42 40936 2384 110545937
Renal impairment 117.92 12.14 233 40745 188212 110360109
Acute generalised exanthematous pustulosis 116.65 12.14 82 40896 21582 110526739
Sepsis 114.17 12.14 322 40656 327024 110221297
Peritonitis 113.07 12.14 95 40883 32512 110515809
Tubulointerstitial nephritis 111.00 12.14 118 40860 54166 110494155
Vestibular disorder 109.55 12.14 40 40938 2592 110545729
Rhinalgia 100.68 12.14 42 40936 3887 110544434
Drug intolerance 90.46 12.14 20 40958 406492 110141829
Bartter's syndrome 89.67 12.14 14 40964 9 110548312
Joint swelling 88.60 12.14 27 40951 442818 110105503
Affective disorder 86.00 12.14 53 40925 11188 110537133
Weight increased 85.01 12.14 25 40953 419619 110128702
Headache 83.24 12.14 124 40854 882253 109666068
Spinal muscular atrophy 81.82 12.14 21 40957 406 110547915
Linear IgA disease 80.25 12.14 37 40941 4352 110543969
Fall 79.86 12.14 64 40914 603418 109944903
Drug ineffective 79.79 12.14 886 40092 1519654 109028667
Pain 74.77 12.14 151 40827 954804 109593517
Nasopharyngitis 73.71 12.14 27 40951 394334 110153987
Synovitis 73.34 12.14 8 40970 274084 110274237
Completed suicide 70.46 12.14 5 40973 242376 110305945
Purpura 70.36 12.14 64 40914 24324 110523997
Stevens-Johnson syndrome 68.96 12.14 86 40892 46815 110501506
Fatigue 68.56 12.14 227 40751 1215731 109332590
Mucosal inflammation 66.38 12.14 124 40854 96017 110452304
Abdominal discomfort 65.54 12.14 32 40946 393826 110154495
Deafness neurosensory 65.18 12.14 42 40936 9577 110538744
Candida infection 64.23 12.14 84 40894 47925 110500396
Rheumatoid arthritis 64.14 12.14 16 40962 299597 110248724
Haemodynamic instability 63.96 12.14 59 40919 22829 110525492
Product dose omission issue 63.65 12.14 20 40958 321762 110226559
Arthropathy 60.30 12.14 16 40962 287506 110260815
Systemic lupus erythematosus 59.70 12.14 11 40967 254327 110293994
Cholestasis 58.67 12.14 94 40884 64424 110483897
Pneumococcal sepsis 57.87 12.14 24 40954 2188 110546133
Arthralgia 57.01 12.14 128 40850 779504 109768817
Extrapyramidal disorder 55.93 12.14 61 40917 28806 110519515
Clostridium difficile infection 55.92 12.14 82 40896 52047 110496274
Oliguria 55.87 12.14 50 40928 18607 110529714
Renal injury 55.74 12.14 50 40928 18663 110529658
Cardiac valve vegetation 55.45 12.14 19 40959 1021 110547300
Helicobacter infection 55.11 12.14 3 40975 181874 110366447
Hand deformity 54.51 12.14 8 40970 218498 110329823
Motor neurone disease 53.80 12.14 17 40961 707 110547614
Asthenia 53.80 12.14 109 40869 688890 109859431
Drug abuse 53.53 12.14 3 40975 177408 110370913
Blood creatinine increased 53.33 12.14 169 40809 182720 110365601
Pemphigus 53.20 12.14 8 40970 214562 110333759
Schizophrenia 52.88 12.14 52 40926 21774 110526547
Infusion related reaction 52.18 12.14 39 40939 381123 110167198
Hallucination, auditory 51.52 12.14 56 40922 26341 110521980
Migraine 51.49 12.14 3 40975 171649 110376672
Excessive eye blinking 51.34 12.14 21 40957 1849 110546472
Hypotension 50.74 12.14 350 40628 523499 110024822
Asthma 50.49 12.14 15 40963 250276 110298045
Neutrophil count increased 50.08 12.14 63 40915 34589 110513732
Seizure 49.35 12.14 187 40791 220998 110327323
Glossodynia 49.19 12.14 11 40967 221993 110326328
Stoma closure 49.12 12.14 14 40964 407 110547914
Peripheral swelling 48.39 12.14 47 40931 403987 110144334
Pain in extremity 48.26 12.14 66 40912 487052 110061269
SARS-CoV-2 test positive 47.99 12.14 44 40934 16891 110531430
Abdominal pain upper 47.42 12.14 36 40942 349075 110199246
Renal tubular disorder 46.83 12.14 31 40947 7398 110540923
Therapeutic product effect incomplete 45.90 12.14 13 40965 223792 110324529
Leukopenia 45.69 12.14 140 40838 148651 110399670
Premature delivery 44.76 12.14 56 40922 30576 110517745
Anaphylactic shock 44.01 12.14 73 40905 51473 110496848
Bacillus infection 43.88 12.14 18 40960 1596 110546725
Noninfectious peritonitis 43.87 12.14 12 40966 299 110548022
Therapeutic product effect decreased 43.52 12.14 18 40960 244298 110304023
Psychotic disorder 43.31 12.14 72 40906 50865 110497456
Fibromyalgia 43.23 12.14 6 40972 170903 110377418
Staphylococcal infection 43.11 12.14 86 40892 69858 110478463
Respiratory tract infection bacterial 43.03 12.14 20 40958 2396 110545925
Swelling 43.01 12.14 40 40938 351001 110197320
Enterococcal infection 42.92 12.14 45 40933 20321 110528000
Neutropenia 42.79 12.14 261 40717 374359 110173962
Muscle spasms 42.73 12.14 25 40953 278132 110270189
Osteoarthritis 42.63 12.14 8 40970 182615 110365706
Anti-cyclic citrullinated peptide antibody positive 42.42 12.14 8 40970 181976 110366345
Hepatocellular injury 42.28 12.14 71 40907 50571 110497750
Insomnia 41.96 12.14 43 40935 360547 110187774
Cellulitis 41.93 12.14 122 40856 125894 110422427
Increased bronchial secretion 41.84 12.14 23 40955 3925 110544396
Aminoaciduria 41.61 12.14 12 40966 364 110547957
Intentional product use issue 41.43 12.14 20 40958 247886 110300435
Petechiae 41.26 12.14 47 40931 23270 110525051
Haemodialysis 40.68 12.14 41 40937 17678 110530643
Agranulocytosis 40.57 12.14 78 40900 61682 110486639
Musculoskeletal stiffness 40.43 12.14 27 40951 279795 110268526
Dizziness 40.15 12.14 129 40849 698064 109850257
Klebsiella infection 40.02 12.14 43 40935 19966 110528355
Antimicrobial susceptibility test resistant 39.91 12.14 12 40966 422 110547899
Lung consolidation 39.39 12.14 32 40946 10444 110537877
Metabolic alkalosis 39.32 12.14 25 40953 5570 110542751
Device related infection 39.29 12.14 60 40918 39459 110508862
Ischaemic cerebral infarction 39.26 12.14 20 40958 2925 110545396
Oropharyngeal oedema 39.10 12.14 12 40966 453 110547868
Infective aneurysm 38.40 12.14 16 40962 1476 110546845
Intentional overdose 37.74 12.14 3 40975 132498 110415823
Psoriatic arthropathy 37.54 12.14 13 40965 196748 110351573
Lymphocyte count decreased 37.24 12.14 72 40906 57171 110491150
Dry mouth 36.81 12.14 14 40964 199934 110348387
Fungal peritonitis 36.79 12.14 15 40963 1310 110547011
Thrombocytopenia 36.68 12.14 238 40740 348647 110199674
Resuscitation 36.45 12.14 19 40959 2914 110545407
Sputum increased 36.25 12.14 24 40954 5727 110542594
Lower respiratory tract infection bacterial 36.11 12.14 14 40964 1071 110547250
Aspergillus infection 36.11 12.14 46 40932 25570 110522751
Aortic valve incompetence 36.03 12.14 31 40947 10950 110537371
Contraindicated product administered 35.80 12.14 24 40954 248243 110300078
Blood cholesterol increased 35.61 12.14 12 40966 184773 110363548
Hepatic enzyme increased 35.40 12.14 40 40938 320852 110227469
Shock haemorrhagic 35.40 12.14 47 40931 27200 110521121
Duodenal ulcer perforation 35.20 12.14 11 40967 177689 110370632
Rash erythematous 35.06 12.14 87 40891 81745 110466576
Face oedema 34.96 12.14 52 40926 33417 110514904
Drug level increased 34.75 12.14 63 40915 47656 110500665
Persistent genital arousal disorder 34.68 12.14 12 40966 664 110547657
Pericarditis 34.64 12.14 19 40959 219095 110329226
Septic embolus 34.56 12.14 17 40961 2309 110546012
Bronchial disorder 34.55 12.14 18 40960 2758 110545563
Arthritis bacterial 34.40 12.14 30 40948 10790 110537531
Blood alkaline phosphatase increased 34.26 12.14 79 40899 70856 110477465
Bursitis 34.21 12.14 4 40974 129914 110418407
Liver abscess 34.19 12.14 26 40952 7713 110540608
Sepsis syndrome 34.09 12.14 15 40963 1581 110546740
Sinusitis 33.81 12.14 36 40942 296652 110251669
Disease complication 33.58 12.14 23 40955 5804 110542517
Cerebral ischaemia 33.42 12.14 31 40947 12073 110536248
Wound 33.35 12.14 23 40955 234414 110313907
Peritoneal dialysis complication 33.10 12.14 17 40961 2529 110545792
Endophthalmitis 32.90 12.14 26 40952 8161 110540160
Metabolic acidosis 32.64 12.14 96 40882 99648 110448673
Depression 32.42 12.14 42 40936 317293 110231028
Staphylococcal sepsis 32.28 12.14 36 40942 17418 110530903
Chest X-ray abnormal 32.07 12.14 26 40952 8461 110539860
Drug interaction 31.94 12.14 304 40674 499879 110048442
Tachycardia 31.86 12.14 167 40811 226478 110321843
Mobility decreased 31.57 12.14 25 40953 237397 110310924
Epidermolysis 31.56 12.14 13 40965 1165 110547156
Gastrointestinal disorder 31.52 12.14 26 40952 241926 110306395
Listeriosis 31.50 12.14 17 40961 2797 110545524
Haematopoietic stem cell mobilisation 31.49 12.14 10 40968 423 110547898
Peripheral blood stem cell apheresis 31.35 12.14 8 40970 151 110548170
Memory impairment 31.25 12.14 17 40961 196927 110351394
Impaired healing 31.18 12.14 17 40961 196700 110351621
Tendon necrosis 31.04 12.14 5 40973 5 110548316
Brain injury 30.60 12.14 31 40947 13445 110534876
Type IV hypersensitivity reaction 30.55 12.14 22 40956 6011 110542310
Vascular device infection 30.44 12.14 34 40944 16478 110531843
Arthritis 30.40 12.14 12 40966 167574 110380747
Circulatory collapse 30.35 12.14 56 40922 42937 110505384
Acinetobacter infection 30.30 12.14 18 40960 3555 110544766
Inappropriate schedule of product administration 30.29 12.14 19 40959 203618 110344703
Anuria 30.11 12.14 41 40937 24300 110524021
Neutropenic sepsis 29.61 12.14 46 40932 30700 110517621
Corneal oedema 29.59 12.14 17 40961 3156 110545165
Encephalopathy 29.43 12.14 81 40897 80974 110467347
Haematochezia 29.34 12.14 4 40974 115520 110432801
Endocarditis bacterial 29.25 12.14 14 40964 1791 110546530
Nausea 29.25 12.14 305 40673 1235385 109312936
Mental status changes postoperative 29.18 12.14 8 40970 201 110548120
Hypopyon 29.05 12.14 13 40965 1427 110546894
Retinal infarction 28.96 12.14 8 40970 207 110548114
Psoriasis 28.94 12.14 8 40970 139985 110408336
Endocarditis candida 28.63 12.14 7 40971 110 110548211
Loss of personal independence in daily activities 28.46 12.14 10 40968 150010 110398311
Lymphadenectomy 28.24 12.14 13 40965 1523 110546798
Disseminated intravascular coagulation 28.17 12.14 53 40925 41233 110507088
Oculocephalogyric reflex absent 28.13 12.14 6 40972 49 110548272
Tonsillitis bacterial 27.86 12.14 8 40970 239 110548082
Hypoaesthesia 27.78 12.14 46 40932 314177 110234144
Shock 27.34 12.14 61 40917 53527 110494794
Rash morbilliform 27.22 12.14 23 40955 7928 110540393
Disease progression 27.19 12.14 169 40809 243865 110304456
Clostridium difficile colitis 27.18 12.14 54 40924 43724 110504597
Myeloma cast nephropathy 27.07 12.14 8 40970 265 110548056
Discomfort 26.83 12.14 24 40954 214683 110333638
Hyperchlorhydria 26.81 12.14 14 40964 2155 110546166
Weight decreased 26.51 12.14 87 40891 467970 110080351
Abscess neck 26.48 12.14 12 40966 1356 110546965
Rheumatoid factor positive 26.34 12.14 8 40970 131632 110416689
Escherichia infection 26.32 12.14 38 40940 23778 110524543
Irritable bowel syndrome 26.31 12.14 14 40964 164201 110384120
Chest discomfort 26.16 12.14 16 40962 173832 110374489
Injection site pain 25.92 12.14 17 40961 177905 110370416
Pseudomonas infection 25.89 12.14 41 40937 27812 110520509
Contusion 25.83 12.14 29 40949 233332 110314989
Skin test positive 25.82 12.14 12 40966 1437 110546884
Skin lesion 25.48 12.14 58 40920 51573 110496748
Metabolic disorder 25.38 12.14 25 40953 10485 110537836
Suicide attempt 25.29 12.14 4 40974 103390 110444931
Procedural hypertension 25.13 12.14 8 40970 341 110547980
Pseudomembranous colitis 25.05 12.14 20 40958 6371 110541950
Chronic obstructive pulmonary disease 25.01 12.14 5 40973 109153 110439168
Blood culture positive 24.81 12.14 23 40955 8953 110539368
Confusion postoperative 24.71 12.14 8 40970 360 110547961
Haemophagocytic lymphohistiocytosis 24.70 12.14 43 40935 31516 110516805
Puerperal pyrexia 24.25 12.14 5 40973 34 110548287
Mycobacterium abscessus infection 23.96 12.14 12 40966 1694 110546627
Respiratory failure 23.91 12.14 149 40829 215183 110333138
Pancytopenia 23.87 12.14 146 40832 209467 110338854
Hyperaldosteronism 23.76 12.14 9 40969 646 110547675
Fungaemia 23.75 12.14 19 40959 6067 110542254
Hypoprothrombinaemia 23.73 12.14 10 40968 949 110547372
Nutritional condition abnormal 23.68 12.14 11 40967 1316 110547005
Blood pressure increased 23.60 12.14 37 40941 258336 110289985
Rheumatic fever 23.55 12.14 8 40970 122571 110425750
Polyglandular disorder 23.48 12.14 7 40971 239 110548082
Infective keratitis 23.47 12.14 6 40972 114 110548207
Hypoglossal nerve paresis 23.38 12.14 6 40972 116 110548205
Splenic abscess 23.33 12.14 10 40968 990 110547331
Joint range of motion decreased 23.32 12.14 8 40970 121824 110426497
Lymphocyte morphology abnormal 23.18 12.14 10 40968 1005 110547316
Clostridial infection 23.17 12.14 19 40959 6283 110542038
Corneal epithelial microcysts 23.11 12.14 5 40973 44 110548277
Symmetrical drug-related intertriginous and flexural exanthema 22.75 12.14 12 40966 1885 110546436
Systemic candida 22.75 12.14 23 40955 9951 110538370
Intestinal ischaemia 22.72 12.14 29 40949 16150 110532171
Malaise 22.57 12.14 151 40827 671668 109876653
Arterial angioplasty 22.53 12.14 5 40973 50 110548271
Red blood cell schistocytes present 22.34 12.14 9 40969 762 110547559
Influenza 22.23 12.14 18 40960 169083 110379238
Musculoskeletal pain 22.23 12.14 21 40957 183002 110365319
Rash macular 21.98 12.14 46 40932 38640 110509681
Brain abscess 21.97 12.14 19 40959 6755 110541566
Renal cortical necrosis 21.94 12.14 8 40970 516 110547805
Folliculitis 21.85 12.14 18 40960 167635 110380686
Incorrect dose administered 21.76 12.14 86 40892 103555 110444766
Sleep disorder 21.64 12.14 25 40953 198619 110349702
Hypersensitivity vasculitis 21.58 12.14 19 40959 6918 110541403
Visual acuity reduced 21.58 12.14 41 40937 32132 110516189
Lemierre syndrome 21.44 12.14 6 40972 163 110548158
Acute respiratory distress syndrome 21.16 12.14 55 40923 53143 110495178
Mast cell degranulation present 21.13 12.14 5 40973 68 110548253
Encephalitis brain stem 21.01 12.14 7 40971 345 110547976
Aortic valve disease 20.95 12.14 12 40966 2215 110546106
Dermatitis bullous 20.89 12.14 29 40949 17500 110530821
Dyspnoea 20.86 12.14 287 40691 1106585 109441736
Cough 20.85 12.14 94 40884 461547 110086774
Obesity 20.75 12.14 8 40970 113343 110434978
Staphylococcal bacteraemia 20.48 12.14 28 40950 16660 110531661
Coagulation time prolonged 20.42 12.14 13 40965 2904 110545417
Disturbance in sexual arousal 20.03 12.14 7 40971 399 110547922
Stomatitis 19.99 12.14 44 40934 270198 110278123
Dialysis 19.80 12.14 30 40948 19589 110528732
Stenotrophomonas test positive 19.78 12.14 7 40971 414 110547907
Macroglossia 19.71 12.14 10 40968 1451 110546870
Scoliosis 19.67 12.14 20 40958 8713 110539608
Oscillopsia 19.61 12.14 7 40971 425 110547896
Infective corneal ulcer 19.55 12.14 4 40974 26 110548295
Hypertension 19.54 12.14 110 40868 509974 110038347
Intervertebral discitis 19.49 12.14 18 40960 6972 110541349
Liver function test abnormal 19.43 12.14 63 40915 68887 110479434
Wheezing 19.34 12.14 41 40937 255189 110293132
Nosocomial infection 19.32 12.14 13 40965 3186 110545135
Constipation 19.23 12.14 68 40910 357718 110190603
Red blood cell sedimentation rate increased 19.22 12.14 3 40975 78299 110470022
Learning disorder 19.14 12.14 8 40970 744 110547577
Hypercholesterolaemia 19.14 12.14 5 40973 90832 110457489
Foot amputation 19.05 12.14 9 40969 1119 110547202
Enterococcal sepsis 18.91 12.14 13 40965 3299 110545022
Product quality issue 18.88 12.14 3 40975 77296 110471025
Drug eruption 18.86 12.14 53 40925 53606 110494715
Methaemoglobinaemia 18.86 12.14 20 40958 9148 110539173
Haemolysis 18.83 12.14 26 40952 15613 110532708
Pseudo-Bartter syndrome 18.74 12.14 5 40973 113 110548208
Intraventricular haemorrhage neonatal 18.63 12.14 3 40975 3 110548318
Dermatitis exfoliative 18.62 12.14 22 40956 11325 110536996
Female reproductive tract disorder 18.58 12.14 7 40971 495 110547826
Sleep disorder due to general medical condition, insomnia type 18.45 12.14 8 40970 105635 110442686
Geotrichum infection 18.43 12.14 9 40969 1203 110547118
Fluid retention 18.38 12.14 6 40972 94301 110454020
Haematuria 18.34 12.14 70 40908 82935 110465386
Fungal endocarditis 18.32 12.14 8 40970 828 110547493
Suicidal ideation 18.27 12.14 6 40972 93931 110454390
Wrong technique in product usage process 18.04 12.14 5 40973 87343 110460978
Acute vestibular syndrome 17.94 12.14 4 40974 41 110548280
Ill-defined disorder 17.90 12.14 19 40959 156834 110391487
Deafness 17.87 12.14 34 40944 26675 110521646
Trichosporon infection 17.83 12.14 9 40969 1291 110547030
Folate deficiency 17.63 12.14 14 40964 4424 110543897
Dermatitis exfoliative generalised 17.55 12.14 21 40957 10951 110537370
ADAMTS13 activity decreased 17.50 12.14 6 40972 323 110547998
Endotracheal intubation 17.48 12.14 16 40962 6128 110542193
Paraesthesia 17.35 12.14 49 40929 276472 110271849
Muscle injury 17.28 12.14 16 40962 140791 110407530
Exfoliative rash 17.26 12.14 14 40964 4560 110543761
Gastrointestinal bacterial infection 17.09 12.14 9 40969 1409 110546912
Pulmonary valve disease 16.99 12.14 6 40972 353 110547968
HIV associated nephropathy 16.94 12.14 6 40972 356 110547965
Reticulocytosis 16.93 12.14 7 40971 633 110547688
Lip dry 16.83 12.14 8 40970 100075 110448246
C-reactive protein abnormal 16.81 12.14 14 40964 129681 110418640
CD4 lymphocytes increased 16.72 12.14 6 40972 370 110547951
Oesophagitis haemorrhagic 16.67 12.14 7 40971 658 110547663
Demyelination 16.67 12.14 19 40959 9410 110538911
Choriomeningitis lymphocytic 16.49 12.14 5 40973 181 110548140
Neonatal respiratory distress syndrome 16.47 12.14 6 40972 386 110547935
Pyroglutamic acidosis 16.46 12.14 10 40968 2058 110546263
Sedation 16.37 12.14 3 40975 69680 110478641
Anaemia folate deficiency 16.32 12.14 7 40971 694 110547627
Disseminated mucormycosis 16.31 12.14 10 40968 2092 110546229
Nasal congestion 16.30 12.14 8 40970 98274 110450047
Gait inability 16.15 12.14 16 40962 136360 110411961
Endocrine disorder 16.06 12.14 8 40970 1116 110547205
Lung infiltration 16.04 12.14 31 40947 24597 110523724
Human herpesvirus 6 infection reactivation 16.03 12.14 8 40970 1121 110547200
Bacteraemia 16.02 12.14 43 40935 42347 110505974
Ejection fraction decreased 15.99 12.14 42 40936 40838 110507483
Leukocytosis 15.91 12.14 50 40928 53778 110494543
Muscle atrophy 15.90 12.14 22 40956 13232 110535089
Platelet count decreased 15.65 12.14 142 40836 230301 110318020
Serratia infection 15.64 12.14 10 40968 2249 110546072
Hypersensitivity 15.53 12.14 87 40891 403911 110144410
Kussmaul respiration 15.49 12.14 6 40972 458 110547863
Congenital herpes simplex infection 15.33 12.14 3 40975 15 110548306
Necrosis 15.32 12.14 20 40958 11386 110536935
Immune reconstitution inflammatory syndrome 15.24 12.14 24 40954 16202 110532119
Paraparesis 15.20 12.14 13 40965 4553 110543768
Wound infection fungal 15.18 12.14 5 40973 238 110548083
Urogenital disorder 15.14 12.14 4 40974 87 110548234
Antineutrophil cytoplasmic antibody 15.14 12.14 4 40974 87 110548234
Status epilepticus 15.06 12.14 35 40943 31536 110516785
Staphylococcus test positive 15.02 12.14 16 40962 7354 110540967
Spinal subdural haematoma 15.02 12.14 5 40973 246 110548075
Antibiotic level below therapeutic 14.93 12.14 4 40974 92 110548229
Infusion site necrosis 14.89 12.14 4 40974 93 110548228
Hypokalaemia 14.81 12.14 117 40861 182331 110365990
Hypoperfusion 14.75 12.14 11 40967 3170 110545151
Rhinorrhoea 14.69 12.14 10 40968 102656 110445665
Road traffic accident 14.66 12.14 11 40967 107387 110440934
Lower respiratory tract infection 14.58 12.14 44 40934 243062 110305259
Respiratory alkalosis 14.55 12.14 14 40964 5707 110542614
Infusion site induration 14.54 12.14 8 40970 1368 110546953
Morganella infection 14.52 12.14 8 40970 1371 110546950
Blood phosphorus decreased 14.50 12.14 16 40962 7649 110540672
Inflammatory marker increased 14.43 12.14 22 40956 14447 110533874
Gastrooesophageal reflux disease 14.41 12.14 28 40950 179948 110368373
Hepatic failure 14.40 12.14 57 40921 68682 110479639
Respiratory distress 14.34 12.14 57 40921 68817 110479504
Haematoma 14.33 12.14 51 40927 58425 110489896
Corneal perforation 14.24 12.14 7 40971 949 110547372
Gait disturbance 14.20 12.14 54 40924 278154 110270167
Nephropathy 14.17 12.14 21 40957 13446 110534875
Blood pressure fluctuation 14.17 12.14 5 40973 74819 110473502
Corneal deposits 14.03 12.14 6 40972 590 110547731
Deafness bilateral 14.01 12.14 10 40968 2694 110545627
Jaundice 13.96 12.14 51 40927 59185 110489136
Auditory neuropathy spectrum disorder 13.91 12.14 3 40975 26 110548295
Bronchitis 13.85 12.14 23 40955 157009 110391312
Motor dysfunction 13.84 12.14 29 40949 24377 110523944
VIIIth nerve injury 13.81 12.14 3 40975 27 110548294
Toxic shock syndrome 13.79 12.14 8 40970 1512 110546809
Condition aggravated 13.77 12.14 363 40615 734473 109813848
Anticonvulsant drug level decreased 13.67 12.14 9 40969 2127 110546194
Cutaneous vasculitis 13.61 12.14 20 40958 12709 110535612
Hyperbilirubinaemia 13.55 12.14 33 40945 30638 110517683
Myalgia 13.52 12.14 40 40938 222341 110325980
Gingival swelling 13.47 12.14 13 40965 5317 110543004
Drug ineffective for unapproved indication 13.24 12.14 74 40904 102764 110445557
Retinal toxicity 13.14 12.14 8 40970 1651 110546670
Osteoporosis 13.14 12.14 8 40970 87144 110461177
Eosinophilic pneumonia acute 13.12 12.14 8 40970 1657 110546664
Peritoneal cloudy effluent 13.11 12.14 6 40972 694 110547627
Leukocyturia 13.07 12.14 9 40969 2291 110546030
Empyema 12.99 12.14 13 40965 5557 110542764
Systemic mycosis 12.95 12.14 11 40967 3818 110544503
Feeling abnormal 12.89 12.14 30 40948 180681 110367640
Jaundice cholestatic 12.89 12.14 21 40957 14587 110533734
Pseudomonas test positive 12.88 12.14 9 40969 2345 110545976
Systemic infection 12.85 12.14 17 40961 9802 110538519
Transaminases increased 12.82 12.14 52 40926 63338 110484983
Ulcerative keratitis 12.76 12.14 12 40966 4754 110543567
Lung disorder 12.76 12.14 30 40948 180017 110368304
Cardiac ventricular thrombosis 12.66 12.14 10 40968 3137 110545184
Back pain 12.63 12.14 83 40895 370913 110177408
Overdose 12.45 12.14 137 40841 233657 110314664
Malignant neoplasm progression 12.44 12.14 29 40949 174538 110373783
Wound dehiscence 12.34 12.14 15 40963 7947 110540374
Hepatosplenomegaly 12.33 12.14 14 40964 6905 110541416
Neurotoxicity 12.28 12.14 39 40939 42168 110506153
Mechanical ventilation 12.22 12.14 10 40968 3297 110545024
Arthritis reactive 12.20 12.14 6 40972 814 110547507
Hyperpyrexia 12.18 12.14 15 40963 8054 110540267
Swollen joint count increased 12.17 12.14 8 40970 83653 110464668

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 54.38 26.68 14 632 15764 97543
Drug ineffective 50.27 26.68 53 593 1580 111727
Pulmonary haemorrhage 29.45 26.68 21 625 355 112952

Pharmacologic Action:

SourceCodeDescription
ATC D06AX07 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
ATC J01GB03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
AMINOGLYCOSIDE ANTIBACTERIALS
Other aminoglycosides
ATC S01AA11 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
ATC S02AA14 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA06 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
FDA CS M0000946 Aminoglycosides
FDA EPC N0000175477 Aminoglycoside Antibacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:70868 antileishmanial agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

D06AX Other antibiotics for topical use 12 drugs
amikacinbacitracinchloramphenicolfusidic acidmupirocinneomycinozenoxacinretapamulinrifamycinrifaximintyrothricinvirginiamycin
J01GB Other aminoglycosides 12 drugs
amikacinarbekacinbekanamycindibekacinisepamicinkanamycinneomycinnetilmicinplazomicinribostamycinsisomicintobramycin
S01AA Antibiotics 27 drugs
amikacinampicillinazidamfenicolazithromycinbacitracinbenzylpenicillincefmenoximecefuroximechloramphenicolchlortetracyclinedibekacindihydrostreptomycin show all 27 →
S02AA Antiinfectives 17 drugs
acetic acidaluminium acetotartrateboric acidcefmenoximechloramphenicolchlorhexidineciprofloxacinclioquinolfosfomycinhydrogen peroxidemiconazoleneomycin show all 17 →
S03AA Antiinfectives 7 drugs
chloramphenicolchlorhexidineciprofloxacinhexamidineneomycinPolymyxin Btetracycline

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Septicemia due to Escherichia coli indication 9323009
Bacterial septicemia indication 10001005 DOID:0040085
Infection due to Pseudomonas aeruginosa indication 11218009
Folliculitis indication 13600006 DOID:4409
Infection of skin AND/OR subcutaneous tissue indication 19824006
Pneumonia due to Pseudomonas indication 41381004
Peritonitis indication 48661000
Pneumonia due to Escherichia coli indication 51530003
Bacterial pneumonia indication 53084003 DOID:874
Blepharoconjunctivitis indication 68659002 DOID:2456
Infection due to Escherichia coli indication 71057007
Bacterial infection due to Serratia indication 71120004
Paronychia indication 71906005 DOID:13117
Rhinoscleroma indication 72409005 DOID:11336
Septicemia due to Serratia indication 82091000
Cholangitis indication 82403002 DOID:9446
Dacryocystitis indication 85777005 DOID:9938
Bacterial meningitis indication 95883001 DOID:9470
Infection of bone indication 111253001
Furunculosis indication 112650006
Infectious disease of abdomen indication 128070006
Bacterial conjunctivitis indication 128350005 DOID:9700
Bacterial infection of skin indication 128936008
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Proteus pneumonia indication 195888009
Sepsis of the newborn indication 206376005
Neonatal pneumonia indication 233619008
Neonatal meningitis indication 276674008
Proteus septicemia indication 300986008
Meibomianitis indication 309779001
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Infectious disorder of joint indication 363162000
Sepsis due to Pseudomonas indication 448813005
Sepsis due to Gram negative bacteria indication 449082003
Skin and Skin Structure Proteus Infection indication
Synergy for Staphylococcus Aureus Pneumonia indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Skin and Skin Structure Pseudomonas Aeruginosa Infection indication
Enterobacter Pneumonia indication
Synergy for Klebsiella Meningitis indication
Burn Wound Infections indication
Complicated UTI with Pseudomonas Aeruginosa indication
Pseudomonas Aeruginosa Osteomyelitis indication
Synergy for Proteus Meningitis indication
Synergy for Group B Streptococcal Septicemia indication
Citrobacter Pneumonia indication
Synergy for Staphylococcal Endocarditis indication
Synergy for Skin and Skin Structure Pseudomonas Aeruginosa Infection indication
Synergy for Pseudomonas Aeruginosa Joint Infection indication
Pseudomonas Aeruginosa Joint Infection indication
Skin and Skin Structure Serratia Infection indication
Synergy for Pseudomonas Aeruginosa Osteomyelitis indication
Synergy for Neonatal Meningitis indication
Pseudomonas Aeruginosa Meningitis indication
Synergy for Staphylococcal Joint Infection indication
Citrobacter Septicemia indication
Pseudomonas Aeruginosa Biliary Tract Infection indication
Skin and Skin Structure Citrobacter Infection indication
Synergy for Pseudomonas Aeruginosa Pneumonia indication
Synergy for Bacterial Meningitis indication
Synergy for Staphylococcus Skin and Skin Structure Infection indication
Complicated Urinary Tract Infections indication
Synergy for Pseudomonas Aeruginosa Meningitis indication
Synergy for Staphylococcal Septicemia indication
Complicated Bacterial Peritonitis indication
Synergy for Staphylococcal Infections indication
Synergy for Pseudomonas Aeruginosa Septicemia indication
Synergy for Citrobacter Meningitis indication
Synergy for Serratia Meningitis indication
Synergy for Enterobacter Meningitis indication
Klebsiella Septicemia indication
Synergy for Escherichia Coli Meningitis indication
Necrotizing enterocolitis in fetus OR newborn off-label use 2707005
Pyrexia of unknown origin off-label use 7520000
Ecthyma gangrenosum off-label use 17732003
Enteric campylobacteriosis off-label use 18081009
Pseudotuberculosis off-label use 36753006
Plague off-label use 58750007 DOID:3482
Infection by Yersinia enterocolitica off-label use 80960004
Infection by Campylobacter fetus off-label use 111835002
Listeria Monocytogenes Septicemia off-label use
Pseudomonas Respiratory Tract Infection in Cystic Fibrosis off-label use
Synergy for Prevention of Enterococcal Endocarditis off-label use
Prevention of Perioperative Infection off-label use
Synergy for Streptococcal Endocarditis off-label use
Synergy for Enterococcal Endocarditis off-label use
Synergy for Listeria Monocytogenes Septicemia off-label use
Synergy for Enterococcal Infections off-label use
Ocular hypertension contraindication 4210003 DOID:9282
Hypocalcemia contraindication 5291005
Herpes simplex keratitis contraindication 9389005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Parkinsonism contraindication 32798002
Dehydration contraindication 34095006
Severe myopia contraindication 34187009
Tuberculosis of eye contraindication 49107007
Tinnitus contraindication 60862001
Diabetes mellitus contraindication 73211009 DOID:9351
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Eye infection contraindication 128351009
Bacterial infection of eye contraindication 128984004
Pregnancy, function contraindication 289908002
Viral eye infection contraindication 312132001
Vaccinia keratitis contraindication 397552005
Vertigo contraindication 399153001
Denuded skin contraindication 418242004
Infant Botulism contraindication
Disorder of the 8th Cranial Nerve contraindication
Gentamicin Toxicity contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Urinary tract infections Indication
Cats Respiratory tract infections Indication
Cats Skin and soft tissue infections Indication
Cats Supportive therapy for secondary bacterial infections associated with panleucopenia Indication
Cats Conjunctivitis Indication
Cattle Infectious bovine keratoconjunctivitis associated with Moraxella bovis Indication
Chickens Prevention of early mortality caused by Escherichia coli Indication
Chickens Prevention of early mortality caused by Salmonella typhimurium Indication
Chickens Prevention of early mortality caused by Pseudomonas aeruginosa Indication
Dogs External eye infections Indication
Dogs Acute and chronic otitis externa caused by bacteria Indication
Dogs Urinary tract infections Indication
Dogs Respiratory tract infections Indication
Dogs Skin and soft tissue infections Indication
Horses Uterus infections Indication
Horses Improving conception in mares with uterine infections Indication
Swine Dysentery associated with Brachyspira hyodysenteriae Indication
Swine PorcinEscherichia colibacillosis caused by Escherichia coli Indication
Turkeys Prevention of early mortality caused by Arizona paracolon infections Indication
Turkeys Reduction or elimination of Arizona hinshawii Indication
Turkeys Reduction or elimination of Salmonella st paul Indication
Turkeys Reduction or elimination of Mycoplasma meleagris Indication

🐶 Veterinary products

ProductApplicantIngredients
Gentocin Durafilm Intervet Inc. 2
Gentocin Solution Intervet Inc. 1
Gentocin Solution Intervet Inc. 1
Gentocin Otic Solution Intervet Inc. 2
Garacin Intervet Inc. 1
Garasol Solution Intervet Inc. 1
Gentocin Ophthalmic Ointment Intervet Inc. 1
Gentocin Ophthalmic Solution Intervet Inc. 1
Garasol Injection Intervet Inc. 1
Garacin Piglet Injection Intervet Inc. 1
Topagen Ointment Intervet Inc. 2
Gentocin (Garacin) Pig Pump Oral Solution Intervet Inc. 1
Gentocin Pink Eye Spray Intervet Inc. 1
Gentocin Topical Spray Intervet Inc. 2
Garacin Soluble Powder Intervet Inc. 1
Gentamicin Sulfate Inj. Sol. Cronus Pharma Specialities India Private Limited 1
Otomax Intervet Inc. 3
Mometamax Otic Suspension Intervet Inc. 3
Easotic Virbac AH Inc. 3
Gentamicin Sulfate Solution 100 mg/ml Cronus Pharma Specialities India Private Limited 1
Gentamicin Sulfate Solution, Legacy Sterile Solution Huvepharma EOOD 1
Gentaglyde Solution Zoetis Inc. 1
Gentamex 100 Bimeda Animal Health Limited 1
GentaMax 100 Elanco US Inc. 1
Genta-Ject, Gentamicin Sulfate Injection Huvepharma EOOD 1
Gentamicin Sulfate Pig Pump Oral Solution Huvepharma EOOD 1
VET BETA-GEN Med-Pharmex Inc. 2
GEN-GARD Huvepharma EOOD 1
Betagen Topical Spray Med-Pharmex Inc. 2
GENTORAL Med-Pharmex Inc. 1
Gentasol Med-Pharmex Inc. 1
Tri-Otic Ointment Med-Pharmex Inc. 3
Vetro-Gen Veterinary Ophthalmic Ointment Dechra Veterinary Products LLC 1
Vetro-Max Fougera Pharmaceuticals Inc. 3
GBC Ointment Cronus Pharma Specialities India Private Limited 3
GB Topical Spray Dechra Veterinary Products LLC 2
Gentamicin Piglet Injection Sparhawk Laboratories Inc. 1
Gentamicin Sulfate Solution Sparhawk Laboratories Inc. 1
Gentamicin Sulfate Topical Spray First Priority Inc. 2
Gentamicin Topical Spray Sparhawk Laboratories Inc. 2
GentaMed-P for Poultry Injection Bimeda Animal Health Limited 1
GentaMed Bimeda Animal Health Limited 1
Mometavet Med-Pharmex Inc. 3
Gentamicin Sulfate Ophthalmic Solution Akorn Animal Health Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dihydrofolate reductase Enzyme IC50 4.74 CHEMBL
Transient receptor potential cation channel subfamily V member 5 Ion channel INHIBITOR IC50 6 IUPHAR
Dihydrofolate reductase Enzyme IC50 4.60 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Ion channel GATING INHIBITOR IC50 5.20 IUPHAR

External reference:

IDSource
4019765 VUID
N0000179542 NUI
D01063 KEGG_DRUG
1403-66-3 SECONDARY_CAS_RN
4018210 VANDF
4019765 VANDF
C3854019 UMLSCUI
CHEBI:17833 CHEBI
CHEMBL6067485 ChEMBL_ID
CHEMBL6067484 ChEMBL_ID
D005839 MESH_DESCRIPTOR_UI
DB00798 DRUGBANK_ID
2427 IUPHAR_LIGAND_ID
1617 INN_ID
T6Z9V48IKG UNII
3467 PUBCHEM_CID
1596450 RXNORM
228599 MMSL
4779 MMSL
d00014 MMSL
002778 NDDF
004898 NDDF
2249001 SNOMEDCT_US
387321007 SNOMEDCT_US
57752001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Gentamicin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9128 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 16 sections
Gentamicin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9129 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 16 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0503 INJECTION, SOLUTION 80 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0505 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0507 INJECTION, SOLUTION 60 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0509 INJECTION, SOLUTION 80 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0511 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9865 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 13 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9865 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 13 sections
Gentamicin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9866 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 13 sections
Gentamicin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9866 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 13 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1207 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 17 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0682 OINTMENT 1 mg TOPICAL ANDA 9 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0683 CREAM 1 mg TOPICAL ANDA 9 sections
GENTAMICIN SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 16590-107 CREAM 1 mg TOPICAL ANDA 10 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 17478-283 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 18 sections
Gentak HUMAN PRESCRIPTION DRUG LABEL 1 17478-284 OINTMENT 3 mg OPHTHALMIC ANDA 18 sections
GENTAMICIN SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 21695-187 SOLUTION 3 mg OPHTHALMIC ANDA 15 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 24208-580 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 14 sections
GENTAMICIN SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 33261-604 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 17 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 45802-046 OINTMENT 1 mg TOPICAL ANDA 11 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 45802-056 CREAM 1 mg TOPICAL ANDA 11 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 45865-672 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 15 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0569 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 14 sections
Gentak HUMAN PRESCRIPTION DRUG LABEL 1 50090-4770 OINTMENT 3 mg OPHTHALMIC ANDA 17 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50436-6752 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 15 sections
GENTAMICIN HUMAN PRESCRIPTION DRUG LABEL 1 51662-1508 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 14 sections
GENTAMICIN SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1597 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 13 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 52565-085 CREAM 1 mg TOPICAL ANDA 11 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 52565-090 OINTMENT 1 mg TOPICAL ANDA 11 sections