All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

gentamicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
aminoglycosides, antibiotics obtained from various Micromonospora	4265	1405-41-0

Description:

Molecule	Description
Synonyms: gentamicin sulfate gentamicin alcomicin gentacin gentamicine sulfate	A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS. Molecular weight: 1390.73 Formula: C60H123N15O21 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.24	g	P

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	6.28 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	0.33 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	1 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	4.70 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
June 19, 1970	FDA	SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	720.70	12.42	623	22914	319764	90285146
Premature delivery	590.26	12.42	258	23279	38504	90566406
Normal labour	582.82	12.42	106	23431	511	90604399
Delivery	486.38	12.42	109	23428	1684	90603226
Drug reaction with eosinophilia and systemic symptoms	267.78	12.42	156	23381	42602	90562308
Renal tubular necrosis	251.37	12.42	106	23431	14449	90590461
Multiple organ dysfunction syndrome	205.61	12.42	158	23379	68178	90536732
Toxic epidermal necrolysis	178.42	12.42	109	23428	32419	90572491
Maternal exposure during pregnancy	167.05	12.42	319	23218	359744	90245166
Pathogen resistance	143.11	12.42	60	23477	8055	90596855
Sepsis	139.58	12.42	201	23336	179613	90425297
Septic shock	138.44	12.42	138	23399	84022	90520888
Renal failure	137.90	12.42	170	23367	130837	90474073
Peritonitis bacterial	121.49	12.42	47	23490	5124	90599786
Ototoxicity	117.78	12.42	36	23501	1928	90602982
Product use in unapproved indication	101.91	12.42	251	23286	335985	90268925
Peritonitis	92.88	12.42	60	23477	19645	90585265
Anaphylactic reaction	91.12	12.42	113	23424	87411	90517499
Bartter's syndrome	87.50	12.42	13	23524	9	90604901
Drug resistance	82.02	12.42	66	23471	30383	90574527
Toxic skin eruption	81.75	12.42	51	23486	15723	90589187
Eosinophilia	81.46	12.42	64	23473	28469	90576441
Mucosal inflammation	77.71	12.42	85	23452	57540	90547370
Abdominal discomfort	77.54	12.42	15	23522	477313	90127597
Nephropathy toxic	75.97	12.42	45	23492	12643	90592267
Joint swelling	73.43	12.42	20	23517	503280	90101630
Pyrexia	71.10	12.42	349	23188	660136	89944774
Premature baby	71.05	12.42	56	23481	25021	90579889
Antibiotic level above therapeutic	70.98	12.42	18	23519	480	90604430
Excessive eye blinking	69.07	12.42	22	23515	1350	90603560
Drug intolerance	68.73	12.42	16	23521	447575	90157335
Renal impairment	62.31	12.42	104	23433	105317	90499593
Shock haemorrhagic	61.97	12.42	39	23498	12206	90592704
Oliguria	61.84	12.42	37	23500	10587	90594323
Neutropenic sepsis	61.32	12.42	45	23492	18085	90586825
Synovitis	61.24	12.42	7	23530	329745	90275165
Drug interaction	61.23	12.42	184	23353	276269	90328641
Pemphigus	60.55	12.42	7	23530	326857	90278053
Tubulointerstitial nephritis	60.05	12.42	51	23486	25292	90579618
Systemic lupus erythematosus	59.54	12.42	11	23526	361885	90243025
Candida infection	58.10	12.42	57	23480	34000	90570910
Stevens-Johnson syndrome	57.40	12.42	53	23484	29323	90575587
Glossodynia	56.92	12.42	8	23529	321771	90283139
Foetal exposure during pregnancy	55.53	12.42	62	23475	42913	90561997
Vestibular disorder	54.66	12.42	19	23518	1530	90603380
Nasopharyngitis	54.28	12.42	19	23518	407085	90197825
Hand deformity	53.29	12.42	7	23530	296355	90308555
Headache	53.28	12.42	89	23448	862657	89742253
Rheumatoid arthritis	51.75	12.42	15	23522	362599	90242311
Arthropathy	50.73	12.42	16	23521	366226	90238684
Endocarditis	49.98	12.42	28	23509	7085	90597825
Weight increased	48.47	12.42	24	23513	417903	90187007
Persistent genital arousal disorder	47.00	12.42	14	23523	686	90604224
Oropharyngeal oedema	46.09	12.42	12	23525	356	90604554
Metabolic alkalosis	45.58	12.42	21	23516	3528	90601382
Infusion related reaction	45.30	12.42	26	23511	416754	90188156
Fatigue	44.30	12.42	153	23384	1153870	89451040
Gastrointestinal disorder	43.96	12.42	7	23530	256680	90348230
Haemodynamic instability	43.96	12.42	31	23506	11708	90593202
Renal injury	42.95	12.42	29	23508	10214	90594696
Escherichia infection	41.84	12.42	34	23503	15861	90589049
Arthritis bacterial	40.93	12.42	25	23512	7420	90597490
Umbilical erythema	39.65	12.42	8	23529	72	90604838
Intraventricular haemorrhage neonatal	39.64	12.42	10	23527	261	90604649
Anti-cyclic citrullinated peptide antibody positive	39.27	12.42	7	23530	236426	90368484
Enterococcal infection	38.85	12.42	27	23510	9964	90594946
Pancytopenia	38.70	12.42	92	23445	120171	90484739
Type 2 diabetes mellitus	38.52	12.42	4	23533	203240	90401670
Hepatic enzyme increased	38.49	12.42	23	23514	360713	90244197
Anuria	37.54	12.42	31	23506	14787	90590123
Mental status changes postoperative	37.54	12.42	9	23528	189	90604721
Acute generalised exanthematous pustulosis	37.53	12.42	30	23507	13673	90591237
Abscess neck	37.48	12.42	12	23525	749	90604161
Linear IgA disease	37.38	12.42	16	23521	2258	90602652
Liver abscess	36.68	12.42	18	23519	3478	90601432
Disseminated intravascular coagulation	36.64	12.42	36	23501	21502	90583408
Hyperchlorhydria	36.40	12.42	15	23522	1926	90602984
Fall	36.34	12.42	43	23494	481767	90123143
Pain	36.25	12.42	135	23402	996206	89608704
Contraindicated product administered	36.18	12.42	19	23518	320120	90284790
Musculoskeletal stiffness	35.95	12.42	16	23521	296516	90308394
Duodenal ulcer perforation	35.79	12.42	7	23530	221281	90383629
Necrotising enterocolitis neonatal	35.60	12.42	9	23528	237	90604673
Confusion postoperative	35.42	12.42	9	23528	242	90604668
Renal tubular disorder	35.11	12.42	17	23520	3190	90601720
Neutropenia	34.97	12.42	133	23404	224771	90380139
Sepsis syndrome	34.58	12.42	12	23525	961	90603949
Fibromyalgia	34.48	12.42	6	23531	206263	90398647
Peripheral swelling	34.33	12.42	34	23503	413072	90191838
Noninfectious peritonitis	34.28	12.42	8	23529	149	90604761
Disturbance in sexual arousal	34.07	12.42	9	23528	283	90604627
Pericarditis	33.66	12.42	14	23523	270137	90334773
Tonsillitis bacterial	33.28	12.42	8	23529	170	90604740
Cholestasis	33.24	12.42	44	23493	36255	90568655
Swelling	33.12	12.42	36	23501	419022	90185888
Tendon necrosis	32.82	12.42	5	23532	5	90604905
Deafness neurosensory	32.65	12.42	21	23516	6820	90598090
Crystalluria	32.42	12.42	10	23527	552	90604358
Therapeutic product effect decreased	32.07	12.42	16	23521	277555	90327355
Perineal pain	32.06	12.42	10	23527	573	90604337
Blood creatinine increased	32.01	12.42	77	23460	101309	90503601
Skin test positive	31.60	12.42	11	23526	889	90604021
Sepsis neonatal	31.56	12.42	10	23527	603	90604307
Psoriatic arthropathy	31.55	12.42	10	23527	228325	90376585
Acute respiratory distress syndrome	31.39	12.42	38	23499	28648	90576262
Thrombocytopenia	31.27	12.42	122	23415	208603	90396307
Staphylococcal sepsis	31.08	12.42	23	23514	9360	90595550
Intentional product use issue	30.87	12.42	9	23528	216883	90388027
Skin lesion	30.74	12.42	43	23494	37322	90567588
Gastrointestinal haemorrhage	30.07	12.42	70	23467	90178	90514732
Wound	30.02	12.42	21	23516	302959	90301951
Discomfort	29.95	12.42	17	23520	274318	90330592
Folate deficiency	29.39	12.42	15	23522	3150	90601760
Guillain-Barre syndrome	29.30	12.42	17	23520	4595	90600315
Clostridial infection	29.22	12.42	17	23520	4619	90600291
Rash erythematous	29.21	12.42	57	23480	65047	90539863
Rash maculo-papular	29.15	12.42	44	23493	40889	90564021
Pain in extremity	29.12	12.42	45	23492	450484	90154426
Renal cortical necrosis	29.05	12.42	8	23529	295	90604615
Blood cholesterol increased	28.94	12.42	9	23528	208003	90396907
Migraine	28.80	12.42	7	23530	190385	90414525
Retinal infarction	28.56	12.42	6	23531	67	90604843
Procedural hypertension	28.19	12.42	8	23529	330	90604580
Coagulation time prolonged	28.14	12.42	12	23525	1678	90603232
Hypopyon	27.65	12.42	10	23527	904	90604006
Female reproductive tract disorder	27.15	12.42	9	23528	627	90604283
Endocarditis bacterial	27.02	12.42	9	23528	636	90604274
Inflammatory marker increased	27.01	12.42	21	23516	9193	90595717
Anaphylactic shock	26.93	12.42	37	23500	31580	90573330
Tachycardia	26.81	12.42	96	23441	157577	90447333
Septic embolus	26.80	12.42	10	23527	987	90603923
Polyglandular disorder	26.29	12.42	7	23530	227	90604683
Staphylococcal infection	26.24	12.42	46	23491	48393	90556517
Hypotension	26.12	12.42	159	23378	325238	90279672
Mycobacterium abscessus infection	26.07	12.42	10	23527	1065	90603845
Necrosis	26.02	12.42	18	23519	6592	90598318
Ejection fraction decreased	25.87	12.42	33	23504	26220	90578690
Muscle injury	25.75	12.42	7	23530	176647	90428263
Lemierre syndrome	25.74	12.42	6	23531	111	90604799
Puerperal pyrexia	25.65	12.42	5	23532	37	90604873
Hypoglossal nerve paresis	25.64	12.42	6	23531	113	90604797
Genital pain	25.60	12.42	9	23528	749	90604161
Arthralgia	25.41	12.42	110	23427	778412	89826498
Blood phosphorus decreased	25.39	12.42	16	23521	5018	90599892
Sleep disorder	25.09	12.42	10	23527	198020	90406890
Asthma	25.04	12.42	16	23521	242144	90362766
Morganella infection	24.95	12.42	9	23528	807	90604103
Lactic acidosis	24.89	12.42	46	23491	50417	90554493
Rheumatoid factor positive	24.65	12.42	7	23530	171643	90433267
Neurotoxicity	24.41	12.42	29	23508	21438	90583472
Low birth weight baby	24.39	12.42	20	23517	9447	90595463
Muscle spasms	24.24	12.42	18	23519	251865	90353045
Therapeutic product effect incomplete	24.23	12.42	10	23527	193886	90411024
Product dose omission issue	24.22	12.42	24	23513	291663	90313247
Peritoneal dialysis complication	24.21	12.42	10	23527	1292	90603618
Drug eruption	23.72	12.42	37	23500	35370	90569540
Memory impairment	23.34	12.42	11	23526	197233	90407677
Folliculitis	23.27	12.42	12	23525	204341	90400569
Human herpesvirus 6 infection reactivation	23.23	12.42	8	23529	626	90604284
Device related infection	23.21	12.42	31	23506	25755	90579155
Application site scab	22.85	12.42	6	23531	184	90604726
Insomnia	22.81	12.42	32	23505	333442	90271468
Gastrointestinal bacterial infection	22.50	12.42	9	23528	1071	90603839
Irritable bowel syndrome	22.43	12.42	13	23524	207435	90397475
Vascular device infection	22.26	12.42	21	23516	11931	90592979
Impaired healing	22.19	12.42	17	23520	234182	90370728
Purpura	22.03	12.42	23	23514	14755	90590155
Shock	22.03	12.42	32	23505	28746	90576164
Seizure	21.87	12.42	88	23449	152541	90452369
Bursitis	21.63	12.42	4	23533	131650	90473260
Malaise	21.50	12.42	79	23458	585907	90019003
Endophthalmitis	21.42	12.42	14	23523	4671	90600239
Hypoperfusion	21.18	12.42	10	23527	1774	90603136
Corneal epithelial microcysts	21.11	12.42	4	23533	25	90604885
Drug ineffective	20.99	12.42	488	23049	1383810	89221100
Haemolytic anaemia	20.74	12.42	20	23517	11677	90593233
Macroglossia	20.68	12.42	8	23529	871	90604039
Necrotising colitis	20.64	12.42	9	23528	1329	90603581
Rheumatic fever	20.63	12.42	7	23530	153114	90451796
Immune reconstitution inflammatory syndrome	20.58	12.42	16	23521	7003	90597907
Anaemia folate deficiency	20.44	12.42	7	23530	539	90604371
Kussmaul respiration	20.36	12.42	6	23531	283	90604627
Aspergillus infection	20.13	12.42	19	23518	10804	90594106
Toxic shock syndrome streptococcal	20.03	12.42	6	23531	300	90604610
Drug level increased	19.99	12.42	30	23507	27732	90577178
Neonatal respiratory failure	19.76	12.42	6	23531	314	90604596
Brain abscess	19.57	12.42	11	23526	2801	90602109
Haemodialysis	19.49	12.42	17	23520	8730	90596180
Death neonatal	19.35	12.42	10	23527	2155	90602755
Dermatitis exfoliative	19.31	12.42	14	23523	5522	90599388
Nausea	19.30	12.42	190	23347	1110126	89494784
Spinal subdural haematoma	19.18	12.42	5	23532	149	90604761
Petechiae	19.12	12.42	22	23515	15719	90589191
Osteoarthritis	18.81	12.42	14	23523	195716	90409194
Hypoaesthesia	18.78	12.42	33	23504	314177	90290733
Stridor	18.75	12.42	13	23524	4780	90600130
Alopecia	18.65	12.42	66	23471	495005	90109905
Skin oedema	18.58	12.42	8	23529	1146	90603764
Neonatal respiratory distress syndrome	18.57	12.42	11	23526	3090	90601820
Haematoma	18.51	12.42	35	23502	39013	90565897
Depression	18.48	12.42	31	23506	300570	90304340
Amnesia	18.47	12.42	3	23534	108502	90496408
Pseudomonas infection	18.44	12.42	21	23516	14844	90590066
Rash morbilliform	18.32	12.42	12	23525	4017	90600893
Exfoliative rash	18.27	12.42	11	23526	3181	90601729
Mobility decreased	18.22	12.42	23	23514	250711	90354199
Gingival swelling	18.22	12.42	13	23524	5000	90599910
Congenital herpes simplex infection	18.16	12.42	3	23534	7	90604903
Musculoskeletal pain	18.13	12.42	11	23526	171240	90433670
Rash macular	18.04	12.42	30	23507	30250	90574660
Dry mouth	17.90	12.42	13	23524	184046	90420864
Clostridium difficile infection	17.82	12.42	33	23504	36212	90568698
Malnutrition	17.77	12.42	23	23514	18535	90586375
Hypocalcaemia	17.69	12.42	36	23501	42332	90562578
Anal ulcer	17.67	12.42	7	23530	812	90604098
Corneal oedema	17.62	12.42	9	23528	1892	90603018
Umbilical cord around neck	17.58	12.42	5	23532	208	90604702
Human herpesvirus 6 infection	17.54	12.42	11	23526	3421	90601489
Congenital hydrocephalus	17.48	12.42	5	23532	212	90604698
Foetal heart rate decreased	17.46	12.42	5	23532	213	90604697
Agranulocytosis	17.37	12.42	32	23505	34970	90569940
Metabolic acidosis	17.26	12.42	42	23495	55634	90549276
Injection site pain	17.24	12.42	12	23525	173687	90431223
Stomatitis	17.19	12.42	28	23509	274670	90330240
Sinusitis	17.12	12.42	40	23497	343048	90261862
Respiratory disorder neonatal	17.09	12.42	8	23529	1393	90603517
Hypotensive crisis	17.06	12.42	4	23533	76	90604834
Asthenia	17.03	12.42	76	23461	533675	90071235
Joint range of motion decreased	16.93	12.42	7	23530	135636	90469274
Hepatic failure	16.88	12.42	34	23503	39694	90565216
Urogenital disorder	16.87	12.42	4	23533	80	90604830
Endocrine disorder	16.60	12.42	7	23530	953	90603957
Systemic infection	16.48	12.42	12	23525	4763	90600147
Neonatal cardiac failure	16.40	12.42	3	23534	15	90604895
Hypervolaemia	16.33	12.42	30	23507	32727	90572183
Hypoparathyroidism	16.31	12.42	7	23530	994	90603916
Contusion	16.30	12.42	25	23512	251191	90353719
Infusion site necrosis	16.22	12.42	4	23533	95	90604815
Disease progression	16.20	12.42	82	23455	156533	90448377
Neonatal disorder	16.14	12.42	6	23531	586	90604324
Pseudo-Bartter syndrome	16.14	12.42	4	23533	97	90604813
Weight decreased	16.14	12.42	48	23489	379862	90225048
Bacterial sepsis	16.08	12.42	12	23525	4943	90599967
Candida test positive	16.06	12.42	7	23530	1032	90603878
Arthritis	16.03	12.42	12	23525	167303	90437607
Hydrops foetalis	15.94	12.42	6	23531	607	90604303
Corneal perforation	15.94	12.42	6	23531	607	90604303
Geotrichum infection	15.91	12.42	6	23531	610	90604300
Gait disturbance	15.89	12.42	27	23510	260469	90344441
Blood culture positive	15.83	12.42	12	23525	5060	90599850
Dialysis	15.77	12.42	17	23520	11312	90593598
Blood alkaline phosphatase increased	15.69	12.42	37	23500	48042	90556868
Hypotonia	15.65	12.42	17	23520	11409	90593501
Abdominal pain upper	15.64	12.42	40	23497	332634	90272276
Pancreatitis haemorrhagic	15.60	12.42	6	23531	643	90604267
Skin bacterial infection	15.59	12.42	6	23531	645	90604265
Meconium in amniotic fluid	15.51	12.42	5	23532	319	90604591
Sleep disorder due to general medical condition, insomnia type	15.49	12.42	7	23530	128687	90476223
Loss of personal independence in daily activities	15.48	12.42	8	23529	136097	90468813
Chronic hepatitis	15.41	12.42	7	23530	1138	90603772
Inappropriate schedule of product administration	15.36	12.42	10	23527	149923	90454987
Fungaemia	15.29	12.42	10	23527	3340	90601570
Hypertension	15.29	12.42	64	23473	457468	90147442
Therapeutic drug monitoring analysis incorrectly performed	15.26	12.42	5	23532	336	90604574
Odynophagia	15.17	12.42	15	23522	9028	90595882
Epstein-Barr virus test positive	15.15	12.42	6	23531	695	90604215
Nephrocalcinosis	14.92	12.42	7	23530	1225	90603685
Neuromuscular blockade	14.91	12.42	5	23532	361	90604549
Lethargy	14.87	12.42	43	23494	63096	90541814
Corneal deposits	14.73	12.42	5	23532	375	90604535
Oscillopsia	14.70	12.42	4	23533	141	90604769
Anaemia	14.66	12.42	148	23389	352654	90252256
Product used for unknown indication	14.63	12.42	6	23531	761	90604149
Bacteraemia	14.52	12.42	23	23514	22277	90582633
Electrocardiogram T wave inversion	14.43	12.42	10	23527	3673	90601237
Blood creatine phosphokinase increased	14.31	12.42	29	23508	33994	90570916
Urine output decreased	14.28	12.42	17	23520	12586	90592324
Clostridium colitis	14.23	12.42	8	23529	2037	90602873
Amniotic cavity infection	14.09	12.42	7	23530	1389	90603521
Wound infection fungal	14.02	12.42	4	23533	168	90604742
Paraparesis	13.97	12.42	9	23528	2929	90601981
Bronchopulmonary aspergillosis	13.96	12.42	16	23521	11382	90593528
Hypotonia neonatal	13.93	12.42	7	23530	1423	90603487
Obesity	13.91	12.42	5	23532	105502	90499408
Skin infection	13.87	12.42	20	23517	17844	90587066
Atrial fibrillation	13.85	12.42	70	23467	133541	90471369
Pulmonary necrosis	13.80	12.42	4	23533	178	90604732
Abdominal sepsis	13.79	12.42	7	23530	1452	90603458
Hyperleukocytosis	13.79	12.42	6	23531	881	90604029
C-reactive protein abnormal	13.75	12.42	8	23529	127421	90477489
Oesophagitis haemorrhagic	13.58	12.42	5	23532	475	90604435
Dyssomnia	13.40	12.42	3	23534	46	90604864
Conjunctival hyperaemia	13.35	12.42	9	23528	3160	90601750
Sudden visual loss	13.17	12.42	3	23534	50	90604860
Erythema	13.04	12.42	103	23434	229143	90375767
Aortic valve incompetence	13.03	12.42	12	23525	6612	90598298
Deafness	13.01	12.42	22	23515	22492	90582418
Skin exfoliation	12.97	12.42	43	23494	67870	90537040
Respiratory failure	12.95	12.42	63	23474	118355	90486555
Neonatal anuria	12.95	12.42	3	23534	54	90604856
Staphylococcus test positive	12.95	12.42	10	23527	4335	90600575
Apnoea	12.88	12.42	14	23523	9400	90595510
Toxic shock syndrome	12.85	12.42	6	23531	1038	90603872
Skin erosion	12.82	12.42	9	23528	3373	90601537
Paraplegia	12.75	12.42	9	23528	3403	90601507
Pulmonary haemorrhage neonatal	12.75	12.42	3	23534	58	90604852
Nasal congestion	12.74	12.42	3	23534	83411	90521499
Deafness bilateral	12.74	12.42	7	23530	1706	90603204
Renal impairment neonatal	12.70	12.42	3	23534	59	90604851
Stenotrophomonas infection	12.66	12.42	8	23529	2521	90602389
Night sweats	12.64	12.42	9	23528	128757	90476153
Paraesthesia	12.63	12.42	29	23508	250297	90354613
Potentiating drug interaction	12.61	12.42	11	23526	5651	90599259
Bradycardia neonatal	12.59	12.42	6	23531	1087	90603823
Tetany	12.50	12.42	8	23529	2576	90602334
Face oedema	12.44	12.42	22	23515	23296	90581614
Immune effector cell-associated neurotoxicity syndrome	12.43	12.42	11	23526	5757	90599153

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	556.94	14.70	860	24039	366477	42229959
Drug reaction with eosinophilia and systemic symptoms	255.06	14.70	205	24694	41870	42554566
Pathogen resistance	227.62	14.70	118	24781	11332	42585104
Renal tubular necrosis	157.02	14.70	110	24789	18244	42578192
Delusion of grandeur	139.13	14.70	50	24849	1946	42594490
Ototoxicity	135.32	14.70	51	24848	2274	42594162
Eosinophilia	128.49	14.70	125	24774	32774	42563662
Nephropathy toxic	123.66	14.70	92	24807	16746	42579690
Drug resistance	118.78	14.70	122	24777	34126	42562310
Rhinalgia	116.65	14.70	43	24856	1801	42594635
Lymphocyte count abnormal	106.00	14.70	42	24857	2145	42594291
Affective disorder	97.57	14.70	54	24845	5906	42590530
Multiple organ dysfunction syndrome	92.03	14.70	186	24713	96849	42499587
Rash maculo-papular	89.56	14.70	110	24789	37393	42559043
Crystalluria	88.86	14.70	28	24871	722	42595714
Septic shock	84.88	14.70	174	24725	91498	42504938
Endocarditis	84.38	14.70	55	24844	8097	42588339
Spinal muscular atrophy	77.38	14.70	22	24877	394	42596042
Acute generalised exanthematous pustulosis	76.97	14.70	53	24846	8542	42587894
Peritonitis bacterial	74.88	14.70	48	24851	6867	42589569
Toxic skin eruption	68.81	14.70	60	24839	13670	42582766
Schizophrenia	67.25	14.70	53	24846	10497	42585939
Renal failure	64.05	14.70	207	24692	143519	42452917
Drug ineffective	61.81	14.70	599	24300	629598	41966838
Product dose omission issue	60.57	14.70	9	24890	154356	42442080
Pneumococcal sepsis	60.40	14.70	25	24874	1430	42595006
Pyrexia	59.87	14.70	414	24485	393628	42202808
Anaphylactic reaction	59.71	14.70	97	24802	42646	42553790
Red blood cell hyperchromic morphology	57.54	14.70	10	24889	10	42596426
Premature baby	57.02	14.70	69	24830	23084	42573352
Death	56.96	14.70	119	24780	471066	42125370
SARS-CoV-2 test positive	55.91	14.70	43	24856	8217	42588219
Fall	55.83	14.70	34	24865	234486	42361950
Asthenia	54.90	14.70	50	24849	280743	42315693
Tubulointerstitial nephritis	53.03	14.70	78	24821	31470	42564966
Lymphocyte count decreased	53.00	14.70	73	24826	27736	42568700
Extrapyramidal disorder	52.46	14.70	56	24843	16356	42580080
Motor neurone disease	50.52	14.70	17	24882	542	42595894
Neutrophil count increased	50.38	14.70	60	24839	19744	42576692
Toxic epidermal necrolysis	49.16	14.70	69	24830	26681	42569755
Increased bronchial secretion	48.97	14.70	25	24874	2321	42594115
Renal impairment	48.39	14.70	158	24741	110070	42486366
Peritonitis	48.30	14.70	57	24842	18576	42577860
Vestibular disorder	48.10	14.70	20	24879	1157	42595279
Dizziness	47.97	14.70	45	24854	249209	42347227
Stoma closure	47.14	14.70	14	24885	294	42596142
Hallucination, auditory	46.25	14.70	50	24849	14814	42581622
Leukopenia	45.09	14.70	120	24779	74626	42521810
Cardiac valve vegetation	43.22	14.70	15	24884	526	42595910
Deafness neurosensory	43.04	14.70	27	24872	3719	42592717
Necrotising colitis	42.79	14.70	19	24880	1292	42595144
Linear IgA disease	42.71	14.70	22	24877	2081	42594355
Purpura	42.40	14.70	43	24856	11836	42584600
Klebsiella infection	42.24	14.70	42	24857	11290	42585146
Sputum increased	41.98	14.70	25	24874	3138	42593298
Completed suicide	41.83	14.70	4	24895	96461	42499975
Respiratory tract infection bacterial	41.77	14.70	21	24878	1888	42594548
Ischaemic cerebral infarction	41.70	14.70	20	24879	1623	42594813
Neonatal disorder	40.87	14.70	16	24883	791	42595645
Aminoaciduria	40.41	14.70	12	24887	252	42596184
Fatigue	40.25	14.70	126	24773	435515	42160921
Congenital multiplex arthrogryposis	40.01	14.70	12	24887	261	42596175
Antimicrobial susceptibility test resistant	39.61	14.70	13	24886	383	42596053
Cerebral palsy	39.51	14.70	13	24886	386	42596050
Lower respiratory tract infection bacterial	38.82	14.70	14	24885	550	42595886
Auditory neuropathy spectrum disorder	38.68	14.70	6	24893	0	42596436
Bacillus infection	38.52	14.70	15	24884	731	42595705
Bronchial disorder	38.49	14.70	18	24881	1380	42595056
Chest X-ray abnormal	38.49	14.70	27	24872	4481	42591955
Fungal peritonitis	38.42	14.70	16	24883	929	42595507
Neonatal candida infection	38.14	14.70	8	24891	35	42596401
Cerebral ischaemia	38.10	14.70	32	24867	6927	42589509
Disease complication	37.48	14.70	23	24876	3047	42593389
Candida infection	37.14	14.70	54	24845	21556	42574880
Resuscitation	36.80	14.70	19	24880	1806	42594630
Lymphadenectomy	36.59	14.70	13	24886	489	42595947
Psychotic disorder	36.40	14.70	63	24836	29145	42567291
Neonatal respiratory distress syndrome	36.15	14.70	26	24873	4487	42591949
Arthralgia	36.12	14.70	40	24859	205198	42391238
Neonatal hypoxia	35.20	14.70	13	24886	547	42595889
Antibiotic level above therapeutic	34.90	14.70	12	24887	409	42596027
Pulmonary haemorrhage	34.87	14.70	38	24861	11359	42585077
Hepatocellular injury	34.78	14.70	55	24844	23623	42572813
Metabolic disorder	34.78	14.70	26	24873	4762	42591674
Headache	34.61	14.70	54	24845	239315	42357121
Drug intolerance	33.17	14.70	4	24895	80420	42516016
Intraventricular haemorrhage neonatal	32.39	14.70	11	24888	361	42596075
Listeriosis	32.28	14.70	16	24883	1395	42595041
Lung consolidation	31.10	14.70	28	24871	6649	42589787
Cholestasis	29.90	14.70	62	24837	32817	42563619
Insomnia	29.74	14.70	16	24883	118237	42478199
Brain injury	29.70	14.70	29	24870	7626	42588810
Conductive deafness	28.85	14.70	11	24888	506	42595930
Inappropriate schedule of product administration	28.84	14.70	10	24889	95892	42500544
Haematopoietic stem cell mobilisation	28.78	14.70	10	24889	352	42596084
Foetal exposure during pregnancy	28.56	14.70	76	24823	47235	42549201
Pain	28.51	14.70	63	24836	244785	42351651
Nutritional condition abnormal	28.47	14.70	11	24888	525	42595911
Low birth weight baby	28.40	14.70	32	24867	9923	42586513
Acinetobacter infection	28.19	14.70	15	24884	1516	42594920
Peripheral blood stem cell apheresis	27.89	14.70	8	24891	148	42596288
Cough	27.86	14.70	38	24861	178065	42418371
Endocarditis candida	27.86	14.70	7	24892	76	42596360
Scoliosis	27.33	14.70	19	24880	3107	42593329
Metabolic acidosis	27.06	14.70	79	24820	51779	42544657
Clostridium difficile colitis	26.69	14.70	46	24853	21206	42575230
Oliguria	26.67	14.70	30	24869	9283	42587153
Symmetrical drug-related intertriginous and flexural exanthema	26.48	14.70	12	24887	856	42595580
Aspergillus infection	26.38	14.70	39	24860	15798	42580638
Nosocomial infection	26.25	14.70	14	24885	1422	42595014
Hypoprothrombinaemia	26.10	14.70	10	24889	466	42595970
Cellulitis	25.85	14.70	87	24812	61498	42534938
Agranulocytosis	25.84	14.70	56	24843	30556	42565880
Haemodynamic instability	25.49	14.70	34	24865	12523	42583913
Weight decreased	25.46	14.70	52	24847	207896	42388540
Thrombocytopenia	25.34	14.70	194	24705	190085	42406351
Red blood cell schistocytes present	25.27	14.70	9	24890	341	42596095
Demyelination	25.27	14.70	19	24880	3510	42592926
Embolia cutis medicamentosa	25.17	14.70	9	24890	345	42596091
Fungaemia	24.97	14.70	18	24881	3118	42593318
Infective keratitis	24.79	14.70	6	24893	55	42596381
Intestinal ischaemia	24.79	14.70	29	24870	9359	42587077
Sepsis	24.76	14.70	200	24699	199134	42397302
Anisocytosis	24.31	14.70	10	24889	563	42595873
Staphylococcal infection	24.29	14.70	62	24837	37581	42558855
Bradycardia neonatal	24.24	14.70	13	24886	1335	42595101
Infective aneurysm	24.20	14.70	12	24887	1047	42595389
Malignant neoplasm progression	24.01	14.70	17	24882	108383	42488053
Chronic obstructive pulmonary disease	24.01	14.70	4	24895	63110	42533326
Haemorrhage neonatal	23.55	14.70	4	24895	3	42596433
Liver abscess	23.46	14.70	21	24878	4949	42591487
Splenic abscess	22.97	14.70	10	24889	648	42595788
Alopecia	22.95	14.70	52	24847	29224	42567212
Motor dysfunction	22.92	14.70	26	24873	8120	42588316
Sepsis neonatal	22.90	14.70	8	24891	286	42596150
Pseudomembranous colitis	22.72	14.70	17	24882	3116	42593320
Pain in extremity	22.68	14.70	33	24866	150571	42445865
Encephalitis brain stem	22.57	14.70	7	24892	171	42596265
Encephalopathy	22.56	14.70	64	24835	41269	42555167
Weight increased	22.55	14.70	18	24881	107965	42488471
Acute vestibular syndrome	22.54	14.70	4	24895	5	42596431
Blood alkaline phosphatase increased	22.37	14.70	56	24843	33541	42562895
Petechiae	22.34	14.70	29	24870	10406	42586030
Scrotal pain	22.27	14.70	11	24888	952	42595484
Systemic candida	22.24	14.70	21	24878	5298	42591138
Diplegia	22.22	14.70	12	24887	1250	42595186
Epidermolysis	22.22	14.70	9	24890	487	42595949
Mucormycosis	22.17	14.70	24	24875	7119	42589317
Therapeutic product effect incomplete	22.02	14.70	7	24892	70932	42525504
Type IV hypersensitivity reaction	21.75	14.70	15	24884	2422	42594014
Depression	21.51	14.70	20	24879	111343	42485093
Lymphocyte morphology abnormal	21.29	14.70	9	24890	543	42595893
Haemodialysis	21.17	14.70	28	24871	10232	42586204
Patent ductus arteriosus	21.16	14.70	17	24882	3459	42592977
Abdominal pain upper	21.02	14.70	11	24888	82598	42513838
CNS ventriculitis	20.66	14.70	8	24891	384	42596052
Dyspnoea	20.55	14.70	163	24736	442458	42153978
Foot amputation	20.45	14.70	10	24889	847	42595589
Otitis media	20.30	14.70	17	24882	3666	42592770
Arterial angioplasty	20.27	14.70	5	24894	50	42596386
Peripheral swelling	20.20	14.70	14	24885	90256	42506180
Nasopharyngitis	20.20	14.70	12	24887	83984	42512452
Injury	20.19	14.70	42	24857	22274	42574162
Infusion site induration	20.18	14.70	8	24891	409	42596027
Hypersensitivity vasculitis	20.03	14.70	16	24883	3228	42593208
Herpes zoster reactivation	19.96	14.70	8	24891	421	42596015
Incorrect dose administered	19.78	14.70	72	24827	52902	42543534
Hypotonia	19.71	14.70	26	24873	9473	42586963
Muscle spasms	19.71	14.70	13	24886	86031	42510405
Circulatory collapse	19.67	14.70	43	24856	23593	42572843
Asthma	19.60	14.70	6	24893	62308	42534128
ADAMTS13 activity decreased	19.37	14.70	6	24893	146	42596290
Loss of personal independence in daily activities	19.30	14.70	3	24896	49813	42546623
Hyperhidrosis	19.01	14.70	15	24884	90497	42505939
CD4 lymphocytes increased	18.96	14.70	6	24893	157	42596279
Mast cell degranulation present	18.86	14.70	5	24894	68	42596368
Application site scab	18.80	14.70	5	24894	69	42596367
Jaundice cholestatic	18.71	14.70	19	24880	5234	42591202
Constipation	18.67	14.70	42	24857	162249	42434187
Aortic valve disease	18.65	14.70	11	24888	1356	42595080
Blood creatinine increased	18.64	14.70	119	24780	109884	42486552
Oculocephalogyric reflex absent	18.63	14.70	4	24895	20	42596416
Neutropenia	18.57	14.70	188	24711	199243	42397193
Joint contracture	18.47	14.70	13	24886	2168	42594268
Nausea	18.46	14.70	146	24753	396653	42199783
Respiratory distress	18.37	14.70	60	24839	41760	42554676
Necrotising enterocolitis neonatal	18.32	14.70	7	24892	324	42596112
Stenotrophomonas test positive	18.18	14.70	7	24892	331	42596105
Macrocytosis	17.95	14.70	10	24889	1107	42595329
Renal tubular disorder	17.94	14.70	18	24881	4891	42591545
Hypotension	17.75	14.70	229	24670	257402	42339034
Infective corneal ulcer	17.74	14.70	4	24895	26	42596410
Face oedema	17.71	14.70	30	24869	13636	42582800
Thrombosis	17.61	14.70	9	24890	68502	42527934
Suicide attempt	17.36	14.70	3	24896	46097	42550339
Polycythaemia	17.32	14.70	14	24885	2872	42593564
Methaemoglobinaemia	17.22	14.70	19	24880	5755	42590681
Coronary artery disease	17.21	14.70	5	24894	53715	42542721
Peritoneal cloudy effluent	17.03	14.70	7	24892	393	42596043
Opisthotonus	16.95	14.70	8	24891	626	42595810
Stevens-Johnson syndrome	16.95	14.70	39	24860	22139	42574297
Aortic valve incompetence	16.91	14.70	20	24879	6528	42589908
Diabetes mellitus	16.83	14.70	7	24892	60080	42536356
Cardiac valve abscess	16.80	14.70	4	24895	34	42596402
Myeloma cast nephropathy	16.66	14.70	5	24894	109	42596327
Cross sensitivity reaction	16.60	14.70	11	24888	1664	42594772
Chondrocalcinosis	16.59	14.70	8	24891	657	42595779
Cardiac arrest neonatal	16.50	14.70	4	24895	37	42596399
Antineutrophil cytoplasmic antibody	16.40	14.70	4	24895	38	42596398
Intentional product use issue	16.26	14.70	11	24888	71822	42524614
Stupor	16.24	14.70	14	24885	3139	42593297
Leukocytosis	16.21	14.70	46	24853	29662	42566774
Muscle atrophy	16	14.70	22	24877	8339	42588097
Condition aggravated	15.99	14.70	227	24672	260527	42335909
Disseminated mucormycosis	15.92	14.70	10	24889	1381	42595055
Wrong technique in product usage process	15.57	14.70	3	24896	42632	42553804
Anaphylactic shock	15.44	14.70	39	24860	23478	42572958
Dry gangrene	15.44	14.70	7	24892	500	42595936
Reticulocytosis	15.38	14.70	6	24893	294	42596142
Abdominal compartment syndrome	15.36	14.70	9	24890	1096	42595340
Staphylococcal bacteraemia	15.19	14.70	25	24874	11096	42585340
Cardio-respiratory arrest neonatal	15.18	14.70	3	24896	9	42596427
Jarisch-Herxheimer reaction	15.16	14.70	8	24891	795	42595641
Choriomeningitis lymphocytic	15.15	14.70	5	24894	150	42596286
Leukocyturia	15.11	14.70	8	24891	800	42595636
Eosinophilic pneumonia acute	15.03	14.70	8	24891	809	42595627
Haemophagocytic lymphohistiocytosis	14.99	14.70	33	24866	18189	42578247
Rash morbilliform	14.76	14.70	15	24884	4138	42592298
Drug level increased	14.72	14.70	41	24858	26159	42570277
Staphylococcal sepsis	14.71	14.70	25	24874	11389	42585047

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	1311.97	12.14	1380	39598	634050	109914271
Drug reaction with eosinophilia and systemic symptoms	524.45	12.14	345	40633	81750	110466571
Renal tubular necrosis	360.87	12.14	191	40787	30284	110518037
Pathogen resistance	348.62	12.14	157	40821	17515	110530806
Ototoxicity	258.05	12.14	85	40893	4046	110544275
Multiple organ dysfunction syndrome	257.64	12.14	299	40679	151411	110396910
Eosinophilia	216.05	12.14	176	40802	57760	110490561
Septic shock	208.63	12.14	274	40704	157254	110391067
Nephropathy toxic	193.80	12.14	123	40855	27355	110520966
Toxic epidermal necrolysis	192.14	12.14	163	40815	56564	110491757
Drug resistance	172.76	12.14	153	40825	56221	110492100
Renal failure	170.43	12.14	303	40675	226271	110322050
Peritonitis bacterial	165.60	12.14	80	40898	10453	110537868
Delusion of grandeur	151.26	12.14	49	40929	2211	110546110
Toxic skin eruption	145.52	12.14	103	40875	27412	110520909
Anaphylactic reaction	133.32	12.14	187	40791	114113	110434208
Rash maculo-papular	132.14	12.14	150	40828	74072	110474249
Pyrexia	131.57	12.14	668	40310	897597	109650724
Antibiotic level above therapeutic	127.98	12.14	36	40942	997	110547324
Crystalluria	126.93	12.14	38	40940	1317	110547004
Endocarditis	125.71	12.14	72	40906	13299	110535022
Lymphocyte count abnormal	120.38	12.14	42	40936	2384	110545937
Renal impairment	117.92	12.14	233	40745	188212	110360109
Acute generalised exanthematous pustulosis	116.65	12.14	82	40896	21582	110526739
Sepsis	114.17	12.14	322	40656	327024	110221297
Peritonitis	113.07	12.14	95	40883	32512	110515809
Tubulointerstitial nephritis	111.00	12.14	118	40860	54166	110494155
Vestibular disorder	109.55	12.14	40	40938	2592	110545729
Rhinalgia	100.68	12.14	42	40936	3887	110544434
Drug intolerance	90.46	12.14	20	40958	406492	110141829
Bartter's syndrome	89.67	12.14	14	40964	9	110548312
Joint swelling	88.60	12.14	27	40951	442818	110105503
Affective disorder	86.00	12.14	53	40925	11188	110537133
Weight increased	85.01	12.14	25	40953	419619	110128702
Headache	83.24	12.14	124	40854	882253	109666068
Spinal muscular atrophy	81.82	12.14	21	40957	406	110547915
Linear IgA disease	80.25	12.14	37	40941	4352	110543969
Fall	79.86	12.14	64	40914	603418	109944903
Drug ineffective	79.79	12.14	886	40092	1519654	109028667
Pain	74.77	12.14	151	40827	954804	109593517
Nasopharyngitis	73.71	12.14	27	40951	394334	110153987
Synovitis	73.34	12.14	8	40970	274084	110274237
Completed suicide	70.46	12.14	5	40973	242376	110305945
Purpura	70.36	12.14	64	40914	24324	110523997
Stevens-Johnson syndrome	68.96	12.14	86	40892	46815	110501506
Fatigue	68.56	12.14	227	40751	1215731	109332590
Mucosal inflammation	66.38	12.14	124	40854	96017	110452304
Abdominal discomfort	65.54	12.14	32	40946	393826	110154495
Deafness neurosensory	65.18	12.14	42	40936	9577	110538744
Candida infection	64.23	12.14	84	40894	47925	110500396
Rheumatoid arthritis	64.14	12.14	16	40962	299597	110248724
Haemodynamic instability	63.96	12.14	59	40919	22829	110525492
Product dose omission issue	63.65	12.14	20	40958	321762	110226559
Arthropathy	60.30	12.14	16	40962	287506	110260815
Systemic lupus erythematosus	59.70	12.14	11	40967	254327	110293994
Cholestasis	58.67	12.14	94	40884	64424	110483897
Pneumococcal sepsis	57.87	12.14	24	40954	2188	110546133
Arthralgia	57.01	12.14	128	40850	779504	109768817
Extrapyramidal disorder	55.93	12.14	61	40917	28806	110519515
Clostridium difficile infection	55.92	12.14	82	40896	52047	110496274
Oliguria	55.87	12.14	50	40928	18607	110529714
Renal injury	55.74	12.14	50	40928	18663	110529658
Cardiac valve vegetation	55.45	12.14	19	40959	1021	110547300
Helicobacter infection	55.11	12.14	3	40975	181874	110366447
Hand deformity	54.51	12.14	8	40970	218498	110329823
Motor neurone disease	53.80	12.14	17	40961	707	110547614
Asthenia	53.80	12.14	109	40869	688890	109859431
Drug abuse	53.53	12.14	3	40975	177408	110370913
Blood creatinine increased	53.33	12.14	169	40809	182720	110365601
Pemphigus	53.20	12.14	8	40970	214562	110333759
Schizophrenia	52.88	12.14	52	40926	21774	110526547
Infusion related reaction	52.18	12.14	39	40939	381123	110167198
Hallucination, auditory	51.52	12.14	56	40922	26341	110521980
Migraine	51.49	12.14	3	40975	171649	110376672
Excessive eye blinking	51.34	12.14	21	40957	1849	110546472
Hypotension	50.74	12.14	350	40628	523499	110024822
Asthma	50.49	12.14	15	40963	250276	110298045
Neutrophil count increased	50.08	12.14	63	40915	34589	110513732
Seizure	49.35	12.14	187	40791	220998	110327323
Glossodynia	49.19	12.14	11	40967	221993	110326328
Stoma closure	49.12	12.14	14	40964	407	110547914
Peripheral swelling	48.39	12.14	47	40931	403987	110144334
Pain in extremity	48.26	12.14	66	40912	487052	110061269
SARS-CoV-2 test positive	47.99	12.14	44	40934	16891	110531430
Abdominal pain upper	47.42	12.14	36	40942	349075	110199246
Renal tubular disorder	46.83	12.14	31	40947	7398	110540923
Therapeutic product effect incomplete	45.90	12.14	13	40965	223792	110324529
Leukopenia	45.69	12.14	140	40838	148651	110399670
Premature delivery	44.76	12.14	56	40922	30576	110517745
Anaphylactic shock	44.01	12.14	73	40905	51473	110496848
Bacillus infection	43.88	12.14	18	40960	1596	110546725
Noninfectious peritonitis	43.87	12.14	12	40966	299	110548022
Therapeutic product effect decreased	43.52	12.14	18	40960	244298	110304023
Psychotic disorder	43.31	12.14	72	40906	50865	110497456
Fibromyalgia	43.23	12.14	6	40972	170903	110377418
Staphylococcal infection	43.11	12.14	86	40892	69858	110478463
Respiratory tract infection bacterial	43.03	12.14	20	40958	2396	110545925
Swelling	43.01	12.14	40	40938	351001	110197320
Enterococcal infection	42.92	12.14	45	40933	20321	110528000
Neutropenia	42.79	12.14	261	40717	374359	110173962
Muscle spasms	42.73	12.14	25	40953	278132	110270189
Osteoarthritis	42.63	12.14	8	40970	182615	110365706
Anti-cyclic citrullinated peptide antibody positive	42.42	12.14	8	40970	181976	110366345
Hepatocellular injury	42.28	12.14	71	40907	50571	110497750
Insomnia	41.96	12.14	43	40935	360547	110187774
Cellulitis	41.93	12.14	122	40856	125894	110422427
Increased bronchial secretion	41.84	12.14	23	40955	3925	110544396
Aminoaciduria	41.61	12.14	12	40966	364	110547957
Intentional product use issue	41.43	12.14	20	40958	247886	110300435
Petechiae	41.26	12.14	47	40931	23270	110525051
Haemodialysis	40.68	12.14	41	40937	17678	110530643
Agranulocytosis	40.57	12.14	78	40900	61682	110486639
Musculoskeletal stiffness	40.43	12.14	27	40951	279795	110268526
Dizziness	40.15	12.14	129	40849	698064	109850257
Klebsiella infection	40.02	12.14	43	40935	19966	110528355
Antimicrobial susceptibility test resistant	39.91	12.14	12	40966	422	110547899
Lung consolidation	39.39	12.14	32	40946	10444	110537877
Metabolic alkalosis	39.32	12.14	25	40953	5570	110542751
Device related infection	39.29	12.14	60	40918	39459	110508862
Ischaemic cerebral infarction	39.26	12.14	20	40958	2925	110545396
Oropharyngeal oedema	39.10	12.14	12	40966	453	110547868
Infective aneurysm	38.40	12.14	16	40962	1476	110546845
Intentional overdose	37.74	12.14	3	40975	132498	110415823
Psoriatic arthropathy	37.54	12.14	13	40965	196748	110351573
Lymphocyte count decreased	37.24	12.14	72	40906	57171	110491150
Dry mouth	36.81	12.14	14	40964	199934	110348387
Fungal peritonitis	36.79	12.14	15	40963	1310	110547011
Thrombocytopenia	36.68	12.14	238	40740	348647	110199674
Resuscitation	36.45	12.14	19	40959	2914	110545407
Sputum increased	36.25	12.14	24	40954	5727	110542594
Lower respiratory tract infection bacterial	36.11	12.14	14	40964	1071	110547250
Aspergillus infection	36.11	12.14	46	40932	25570	110522751
Aortic valve incompetence	36.03	12.14	31	40947	10950	110537371
Contraindicated product administered	35.80	12.14	24	40954	248243	110300078
Blood cholesterol increased	35.61	12.14	12	40966	184773	110363548
Hepatic enzyme increased	35.40	12.14	40	40938	320852	110227469
Shock haemorrhagic	35.40	12.14	47	40931	27200	110521121
Duodenal ulcer perforation	35.20	12.14	11	40967	177689	110370632
Rash erythematous	35.06	12.14	87	40891	81745	110466576
Face oedema	34.96	12.14	52	40926	33417	110514904
Drug level increased	34.75	12.14	63	40915	47656	110500665
Persistent genital arousal disorder	34.68	12.14	12	40966	664	110547657
Pericarditis	34.64	12.14	19	40959	219095	110329226
Septic embolus	34.56	12.14	17	40961	2309	110546012
Bronchial disorder	34.55	12.14	18	40960	2758	110545563
Arthritis bacterial	34.40	12.14	30	40948	10790	110537531
Blood alkaline phosphatase increased	34.26	12.14	79	40899	70856	110477465
Bursitis	34.21	12.14	4	40974	129914	110418407
Liver abscess	34.19	12.14	26	40952	7713	110540608
Sepsis syndrome	34.09	12.14	15	40963	1581	110546740
Sinusitis	33.81	12.14	36	40942	296652	110251669
Disease complication	33.58	12.14	23	40955	5804	110542517
Cerebral ischaemia	33.42	12.14	31	40947	12073	110536248
Wound	33.35	12.14	23	40955	234414	110313907
Peritoneal dialysis complication	33.10	12.14	17	40961	2529	110545792
Endophthalmitis	32.90	12.14	26	40952	8161	110540160
Metabolic acidosis	32.64	12.14	96	40882	99648	110448673
Depression	32.42	12.14	42	40936	317293	110231028
Staphylococcal sepsis	32.28	12.14	36	40942	17418	110530903
Chest X-ray abnormal	32.07	12.14	26	40952	8461	110539860
Drug interaction	31.94	12.14	304	40674	499879	110048442
Tachycardia	31.86	12.14	167	40811	226478	110321843
Mobility decreased	31.57	12.14	25	40953	237397	110310924
Epidermolysis	31.56	12.14	13	40965	1165	110547156
Gastrointestinal disorder	31.52	12.14	26	40952	241926	110306395
Listeriosis	31.50	12.14	17	40961	2797	110545524
Haematopoietic stem cell mobilisation	31.49	12.14	10	40968	423	110547898
Peripheral blood stem cell apheresis	31.35	12.14	8	40970	151	110548170
Memory impairment	31.25	12.14	17	40961	196927	110351394
Impaired healing	31.18	12.14	17	40961	196700	110351621
Tendon necrosis	31.04	12.14	5	40973	5	110548316
Brain injury	30.60	12.14	31	40947	13445	110534876
Type IV hypersensitivity reaction	30.55	12.14	22	40956	6011	110542310
Vascular device infection	30.44	12.14	34	40944	16478	110531843
Arthritis	30.40	12.14	12	40966	167574	110380747
Circulatory collapse	30.35	12.14	56	40922	42937	110505384
Acinetobacter infection	30.30	12.14	18	40960	3555	110544766
Inappropriate schedule of product administration	30.29	12.14	19	40959	203618	110344703
Anuria	30.11	12.14	41	40937	24300	110524021
Neutropenic sepsis	29.61	12.14	46	40932	30700	110517621
Corneal oedema	29.59	12.14	17	40961	3156	110545165
Encephalopathy	29.43	12.14	81	40897	80974	110467347
Haematochezia	29.34	12.14	4	40974	115520	110432801
Endocarditis bacterial	29.25	12.14	14	40964	1791	110546530
Nausea	29.25	12.14	305	40673	1235385	109312936
Mental status changes postoperative	29.18	12.14	8	40970	201	110548120
Hypopyon	29.05	12.14	13	40965	1427	110546894
Retinal infarction	28.96	12.14	8	40970	207	110548114
Psoriasis	28.94	12.14	8	40970	139985	110408336
Endocarditis candida	28.63	12.14	7	40971	110	110548211
Loss of personal independence in daily activities	28.46	12.14	10	40968	150010	110398311
Lymphadenectomy	28.24	12.14	13	40965	1523	110546798
Disseminated intravascular coagulation	28.17	12.14	53	40925	41233	110507088
Oculocephalogyric reflex absent	28.13	12.14	6	40972	49	110548272
Tonsillitis bacterial	27.86	12.14	8	40970	239	110548082
Hypoaesthesia	27.78	12.14	46	40932	314177	110234144
Shock	27.34	12.14	61	40917	53527	110494794
Rash morbilliform	27.22	12.14	23	40955	7928	110540393
Disease progression	27.19	12.14	169	40809	243865	110304456
Clostridium difficile colitis	27.18	12.14	54	40924	43724	110504597
Myeloma cast nephropathy	27.07	12.14	8	40970	265	110548056
Discomfort	26.83	12.14	24	40954	214683	110333638
Hyperchlorhydria	26.81	12.14	14	40964	2155	110546166
Weight decreased	26.51	12.14	87	40891	467970	110080351
Abscess neck	26.48	12.14	12	40966	1356	110546965
Rheumatoid factor positive	26.34	12.14	8	40970	131632	110416689
Escherichia infection	26.32	12.14	38	40940	23778	110524543
Irritable bowel syndrome	26.31	12.14	14	40964	164201	110384120
Chest discomfort	26.16	12.14	16	40962	173832	110374489
Injection site pain	25.92	12.14	17	40961	177905	110370416
Pseudomonas infection	25.89	12.14	41	40937	27812	110520509
Contusion	25.83	12.14	29	40949	233332	110314989
Skin test positive	25.82	12.14	12	40966	1437	110546884
Skin lesion	25.48	12.14	58	40920	51573	110496748
Metabolic disorder	25.38	12.14	25	40953	10485	110537836
Suicide attempt	25.29	12.14	4	40974	103390	110444931
Procedural hypertension	25.13	12.14	8	40970	341	110547980
Pseudomembranous colitis	25.05	12.14	20	40958	6371	110541950
Chronic obstructive pulmonary disease	25.01	12.14	5	40973	109153	110439168
Blood culture positive	24.81	12.14	23	40955	8953	110539368
Confusion postoperative	24.71	12.14	8	40970	360	110547961
Haemophagocytic lymphohistiocytosis	24.70	12.14	43	40935	31516	110516805
Puerperal pyrexia	24.25	12.14	5	40973	34	110548287
Mycobacterium abscessus infection	23.96	12.14	12	40966	1694	110546627
Respiratory failure	23.91	12.14	149	40829	215183	110333138
Pancytopenia	23.87	12.14	146	40832	209467	110338854
Hyperaldosteronism	23.76	12.14	9	40969	646	110547675
Fungaemia	23.75	12.14	19	40959	6067	110542254
Hypoprothrombinaemia	23.73	12.14	10	40968	949	110547372
Nutritional condition abnormal	23.68	12.14	11	40967	1316	110547005
Blood pressure increased	23.60	12.14	37	40941	258336	110289985
Rheumatic fever	23.55	12.14	8	40970	122571	110425750
Polyglandular disorder	23.48	12.14	7	40971	239	110548082
Infective keratitis	23.47	12.14	6	40972	114	110548207
Hypoglossal nerve paresis	23.38	12.14	6	40972	116	110548205
Splenic abscess	23.33	12.14	10	40968	990	110547331
Joint range of motion decreased	23.32	12.14	8	40970	121824	110426497
Lymphocyte morphology abnormal	23.18	12.14	10	40968	1005	110547316
Clostridial infection	23.17	12.14	19	40959	6283	110542038
Corneal epithelial microcysts	23.11	12.14	5	40973	44	110548277
Symmetrical drug-related intertriginous and flexural exanthema	22.75	12.14	12	40966	1885	110546436
Systemic candida	22.75	12.14	23	40955	9951	110538370
Intestinal ischaemia	22.72	12.14	29	40949	16150	110532171
Malaise	22.57	12.14	151	40827	671668	109876653
Arterial angioplasty	22.53	12.14	5	40973	50	110548271
Red blood cell schistocytes present	22.34	12.14	9	40969	762	110547559
Influenza	22.23	12.14	18	40960	169083	110379238
Musculoskeletal pain	22.23	12.14	21	40957	183002	110365319
Rash macular	21.98	12.14	46	40932	38640	110509681
Brain abscess	21.97	12.14	19	40959	6755	110541566
Renal cortical necrosis	21.94	12.14	8	40970	516	110547805
Folliculitis	21.85	12.14	18	40960	167635	110380686
Incorrect dose administered	21.76	12.14	86	40892	103555	110444766
Sleep disorder	21.64	12.14	25	40953	198619	110349702
Hypersensitivity vasculitis	21.58	12.14	19	40959	6918	110541403
Visual acuity reduced	21.58	12.14	41	40937	32132	110516189
Lemierre syndrome	21.44	12.14	6	40972	163	110548158
Acute respiratory distress syndrome	21.16	12.14	55	40923	53143	110495178
Mast cell degranulation present	21.13	12.14	5	40973	68	110548253
Encephalitis brain stem	21.01	12.14	7	40971	345	110547976
Aortic valve disease	20.95	12.14	12	40966	2215	110546106
Dermatitis bullous	20.89	12.14	29	40949	17500	110530821
Dyspnoea	20.86	12.14	287	40691	1106585	109441736
Cough	20.85	12.14	94	40884	461547	110086774
Obesity	20.75	12.14	8	40970	113343	110434978
Staphylococcal bacteraemia	20.48	12.14	28	40950	16660	110531661
Coagulation time prolonged	20.42	12.14	13	40965	2904	110545417
Disturbance in sexual arousal	20.03	12.14	7	40971	399	110547922
Stomatitis	19.99	12.14	44	40934	270198	110278123
Dialysis	19.80	12.14	30	40948	19589	110528732
Stenotrophomonas test positive	19.78	12.14	7	40971	414	110547907
Macroglossia	19.71	12.14	10	40968	1451	110546870
Scoliosis	19.67	12.14	20	40958	8713	110539608
Oscillopsia	19.61	12.14	7	40971	425	110547896
Infective corneal ulcer	19.55	12.14	4	40974	26	110548295
Hypertension	19.54	12.14	110	40868	509974	110038347
Intervertebral discitis	19.49	12.14	18	40960	6972	110541349
Liver function test abnormal	19.43	12.14	63	40915	68887	110479434
Wheezing	19.34	12.14	41	40937	255189	110293132
Nosocomial infection	19.32	12.14	13	40965	3186	110545135
Constipation	19.23	12.14	68	40910	357718	110190603
Red blood cell sedimentation rate increased	19.22	12.14	3	40975	78299	110470022
Learning disorder	19.14	12.14	8	40970	744	110547577
Hypercholesterolaemia	19.14	12.14	5	40973	90832	110457489
Foot amputation	19.05	12.14	9	40969	1119	110547202
Enterococcal sepsis	18.91	12.14	13	40965	3299	110545022
Product quality issue	18.88	12.14	3	40975	77296	110471025
Drug eruption	18.86	12.14	53	40925	53606	110494715
Methaemoglobinaemia	18.86	12.14	20	40958	9148	110539173
Haemolysis	18.83	12.14	26	40952	15613	110532708
Pseudo-Bartter syndrome	18.74	12.14	5	40973	113	110548208
Intraventricular haemorrhage neonatal	18.63	12.14	3	40975	3	110548318
Dermatitis exfoliative	18.62	12.14	22	40956	11325	110536996
Female reproductive tract disorder	18.58	12.14	7	40971	495	110547826
Sleep disorder due to general medical condition, insomnia type	18.45	12.14	8	40970	105635	110442686
Geotrichum infection	18.43	12.14	9	40969	1203	110547118
Fluid retention	18.38	12.14	6	40972	94301	110454020
Haematuria	18.34	12.14	70	40908	82935	110465386
Fungal endocarditis	18.32	12.14	8	40970	828	110547493
Suicidal ideation	18.27	12.14	6	40972	93931	110454390
Wrong technique in product usage process	18.04	12.14	5	40973	87343	110460978
Acute vestibular syndrome	17.94	12.14	4	40974	41	110548280
Ill-defined disorder	17.90	12.14	19	40959	156834	110391487
Deafness	17.87	12.14	34	40944	26675	110521646
Trichosporon infection	17.83	12.14	9	40969	1291	110547030
Folate deficiency	17.63	12.14	14	40964	4424	110543897
Dermatitis exfoliative generalised	17.55	12.14	21	40957	10951	110537370
ADAMTS13 activity decreased	17.50	12.14	6	40972	323	110547998
Endotracheal intubation	17.48	12.14	16	40962	6128	110542193
Paraesthesia	17.35	12.14	49	40929	276472	110271849
Muscle injury	17.28	12.14	16	40962	140791	110407530
Exfoliative rash	17.26	12.14	14	40964	4560	110543761
Gastrointestinal bacterial infection	17.09	12.14	9	40969	1409	110546912
Pulmonary valve disease	16.99	12.14	6	40972	353	110547968
HIV associated nephropathy	16.94	12.14	6	40972	356	110547965
Reticulocytosis	16.93	12.14	7	40971	633	110547688
Lip dry	16.83	12.14	8	40970	100075	110448246
C-reactive protein abnormal	16.81	12.14	14	40964	129681	110418640
CD4 lymphocytes increased	16.72	12.14	6	40972	370	110547951
Oesophagitis haemorrhagic	16.67	12.14	7	40971	658	110547663
Demyelination	16.67	12.14	19	40959	9410	110538911
Choriomeningitis lymphocytic	16.49	12.14	5	40973	181	110548140
Neonatal respiratory distress syndrome	16.47	12.14	6	40972	386	110547935
Pyroglutamic acidosis	16.46	12.14	10	40968	2058	110546263
Sedation	16.37	12.14	3	40975	69680	110478641
Anaemia folate deficiency	16.32	12.14	7	40971	694	110547627
Disseminated mucormycosis	16.31	12.14	10	40968	2092	110546229
Nasal congestion	16.30	12.14	8	40970	98274	110450047
Gait inability	16.15	12.14	16	40962	136360	110411961
Endocrine disorder	16.06	12.14	8	40970	1116	110547205
Lung infiltration	16.04	12.14	31	40947	24597	110523724
Human herpesvirus 6 infection reactivation	16.03	12.14	8	40970	1121	110547200
Bacteraemia	16.02	12.14	43	40935	42347	110505974
Ejection fraction decreased	15.99	12.14	42	40936	40838	110507483
Leukocytosis	15.91	12.14	50	40928	53778	110494543
Muscle atrophy	15.90	12.14	22	40956	13232	110535089
Platelet count decreased	15.65	12.14	142	40836	230301	110318020
Serratia infection	15.64	12.14	10	40968	2249	110546072
Hypersensitivity	15.53	12.14	87	40891	403911	110144410
Kussmaul respiration	15.49	12.14	6	40972	458	110547863
Congenital herpes simplex infection	15.33	12.14	3	40975	15	110548306
Necrosis	15.32	12.14	20	40958	11386	110536935
Immune reconstitution inflammatory syndrome	15.24	12.14	24	40954	16202	110532119
Paraparesis	15.20	12.14	13	40965	4553	110543768
Wound infection fungal	15.18	12.14	5	40973	238	110548083
Urogenital disorder	15.14	12.14	4	40974	87	110548234
Antineutrophil cytoplasmic antibody	15.14	12.14	4	40974	87	110548234
Status epilepticus	15.06	12.14	35	40943	31536	110516785
Staphylococcus test positive	15.02	12.14	16	40962	7354	110540967
Spinal subdural haematoma	15.02	12.14	5	40973	246	110548075
Antibiotic level below therapeutic	14.93	12.14	4	40974	92	110548229
Infusion site necrosis	14.89	12.14	4	40974	93	110548228
Hypokalaemia	14.81	12.14	117	40861	182331	110365990
Hypoperfusion	14.75	12.14	11	40967	3170	110545151
Rhinorrhoea	14.69	12.14	10	40968	102656	110445665
Road traffic accident	14.66	12.14	11	40967	107387	110440934
Lower respiratory tract infection	14.58	12.14	44	40934	243062	110305259
Respiratory alkalosis	14.55	12.14	14	40964	5707	110542614
Infusion site induration	14.54	12.14	8	40970	1368	110546953
Morganella infection	14.52	12.14	8	40970	1371	110546950
Blood phosphorus decreased	14.50	12.14	16	40962	7649	110540672
Inflammatory marker increased	14.43	12.14	22	40956	14447	110533874
Gastrooesophageal reflux disease	14.41	12.14	28	40950	179948	110368373
Hepatic failure	14.40	12.14	57	40921	68682	110479639
Respiratory distress	14.34	12.14	57	40921	68817	110479504
Haematoma	14.33	12.14	51	40927	58425	110489896
Corneal perforation	14.24	12.14	7	40971	949	110547372
Gait disturbance	14.20	12.14	54	40924	278154	110270167
Nephropathy	14.17	12.14	21	40957	13446	110534875
Blood pressure fluctuation	14.17	12.14	5	40973	74819	110473502
Corneal deposits	14.03	12.14	6	40972	590	110547731
Deafness bilateral	14.01	12.14	10	40968	2694	110545627
Jaundice	13.96	12.14	51	40927	59185	110489136
Auditory neuropathy spectrum disorder	13.91	12.14	3	40975	26	110548295
Bronchitis	13.85	12.14	23	40955	157009	110391312
Motor dysfunction	13.84	12.14	29	40949	24377	110523944
VIIIth nerve injury	13.81	12.14	3	40975	27	110548294
Toxic shock syndrome	13.79	12.14	8	40970	1512	110546809
Condition aggravated	13.77	12.14	363	40615	734473	109813848
Anticonvulsant drug level decreased	13.67	12.14	9	40969	2127	110546194
Cutaneous vasculitis	13.61	12.14	20	40958	12709	110535612
Hyperbilirubinaemia	13.55	12.14	33	40945	30638	110517683
Myalgia	13.52	12.14	40	40938	222341	110325980
Gingival swelling	13.47	12.14	13	40965	5317	110543004
Drug ineffective for unapproved indication	13.24	12.14	74	40904	102764	110445557
Retinal toxicity	13.14	12.14	8	40970	1651	110546670
Osteoporosis	13.14	12.14	8	40970	87144	110461177
Eosinophilic pneumonia acute	13.12	12.14	8	40970	1657	110546664
Peritoneal cloudy effluent	13.11	12.14	6	40972	694	110547627
Leukocyturia	13.07	12.14	9	40969	2291	110546030
Empyema	12.99	12.14	13	40965	5557	110542764
Systemic mycosis	12.95	12.14	11	40967	3818	110544503
Feeling abnormal	12.89	12.14	30	40948	180681	110367640
Jaundice cholestatic	12.89	12.14	21	40957	14587	110533734
Pseudomonas test positive	12.88	12.14	9	40969	2345	110545976
Systemic infection	12.85	12.14	17	40961	9802	110538519
Transaminases increased	12.82	12.14	52	40926	63338	110484983
Ulcerative keratitis	12.76	12.14	12	40966	4754	110543567
Lung disorder	12.76	12.14	30	40948	180017	110368304
Cardiac ventricular thrombosis	12.66	12.14	10	40968	3137	110545184
Back pain	12.63	12.14	83	40895	370913	110177408
Overdose	12.45	12.14	137	40841	233657	110314664
Malignant neoplasm progression	12.44	12.14	29	40949	174538	110373783
Wound dehiscence	12.34	12.14	15	40963	7947	110540374
Hepatosplenomegaly	12.33	12.14	14	40964	6905	110541416
Neurotoxicity	12.28	12.14	39	40939	42168	110506153
Mechanical ventilation	12.22	12.14	10	40968	3297	110545024
Arthritis reactive	12.20	12.14	6	40972	814	110547507
Hyperpyrexia	12.18	12.14	15	40963	8054	110540267
Swollen joint count increased	12.17	12.14	8	40970	83653	110464668

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Foetal exposure during pregnancy	54.38	26.68	14	632	15764	97543
Drug ineffective	50.27	26.68	53	593	1580	111727
Pulmonary haemorrhage	29.45	26.68	21	625	355	112952

Pharmacologic Action:

Source	Code	Description
ATC	D06AX07	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use
ATC	J01GB03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMINOGLYCOSIDE ANTIBACTERIALS Other aminoglycosides
ATC	S01AA11	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
ATC	S02AA14	SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives
ATC	S03AA06	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives
FDA CS	M0000946	Aminoglycosides
FDA EPC	N0000175477	Aminoglycoside Antibacterial
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D011500	Protein Synthesis Inhibitors
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35441	antiinfective agent
CHEBI has role	CHEBI:49201	anti-ulcer drug
CHEBI has role	CHEBI:50177	dermatologic drug
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:70868	antileishmanial agent
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:66981	ophthalmology drug

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J01GB Other aminoglycosides 12 drugs

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S03AA Antiinfectives 7 drugs

chloramphenicolchlorhexidineciprofloxacinhexamidineneomycinPolymyxin Btetracycline

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Septicemia due to Escherichia coli	indication	9323009
Bacterial septicemia	indication	10001005	DOID:0040085
Infection due to Pseudomonas aeruginosa	indication	11218009
Folliculitis	indication	13600006	DOID:4409
Infection of skin AND/OR subcutaneous tissue	indication	19824006
Pneumonia due to Pseudomonas	indication	41381004
Peritonitis	indication	48661000
Pneumonia due to Escherichia coli	indication	51530003
Bacterial pneumonia	indication	53084003	DOID:874
Blepharoconjunctivitis	indication	68659002	DOID:2456
Infection due to Escherichia coli	indication	71057007
Bacterial infection due to Serratia	indication	71120004
Paronychia	indication	71906005	DOID:13117
Rhinoscleroma	indication	72409005	DOID:11336
Septicemia due to Serratia	indication	82091000
Cholangitis	indication	82403002	DOID:9446
Dacryocystitis	indication	85777005	DOID:9938
Bacterial meningitis	indication	95883001	DOID:9470
Infection of bone	indication	111253001
Furunculosis	indication	112650006
Infectious disease of abdomen	indication	128070006
Bacterial conjunctivitis	indication	128350005	DOID:9700
Bacterial infection of skin	indication	128936008
Infection due to Enterobacteriaceae	indication	128945009
Bacterial infection due to Klebsiella pneumoniae	indication	186435004
Proteus pneumonia	indication	195888009
Sepsis of the newborn	indication	206376005
Neonatal pneumonia	indication	233619008
Neonatal meningitis	indication	276674008
Proteus septicemia	indication	300986008
Meibomianitis	indication	309779001
Infective blepharitis	indication	312219000
Bacterial keratitis	indication	314557000
Infectious disorder of joint	indication	363162000
Sepsis due to Pseudomonas	indication	448813005
Sepsis due to Gram negative bacteria	indication	449082003
Skin and Skin Structure Proteus Infection	indication
Synergy for Staphylococcus Aureus Pneumonia	indication
Gram-Negative Aerobic Bacillary Pneumonia	indication
Skin and Skin Structure Pseudomonas Aeruginosa Infection	indication
Enterobacter Pneumonia	indication
Synergy for Klebsiella Meningitis	indication
Burn Wound Infections	indication
Complicated UTI with Pseudomonas Aeruginosa	indication
Pseudomonas Aeruginosa Osteomyelitis	indication
Synergy for Proteus Meningitis	indication
Synergy for Group B Streptococcal Septicemia	indication
Citrobacter Pneumonia	indication
Synergy for Staphylococcal Endocarditis	indication
Synergy for Skin and Skin Structure Pseudomonas Aeruginosa Infection	indication
Synergy for Pseudomonas Aeruginosa Joint Infection	indication
Pseudomonas Aeruginosa Joint Infection	indication
Skin and Skin Structure Serratia Infection	indication
Synergy for Pseudomonas Aeruginosa Osteomyelitis	indication
Synergy for Neonatal Meningitis	indication
Pseudomonas Aeruginosa Meningitis	indication
Synergy for Staphylococcal Joint Infection	indication
Citrobacter Septicemia	indication
Pseudomonas Aeruginosa Biliary Tract Infection	indication
Skin and Skin Structure Citrobacter Infection	indication
Synergy for Pseudomonas Aeruginosa Pneumonia	indication
Synergy for Bacterial Meningitis	indication
Synergy for Staphylococcus Skin and Skin Structure Infection	indication
Complicated Urinary Tract Infections	indication
Synergy for Pseudomonas Aeruginosa Meningitis	indication
Synergy for Staphylococcal Septicemia	indication
Complicated Bacterial Peritonitis	indication
Synergy for Staphylococcal Infections	indication
Synergy for Pseudomonas Aeruginosa Septicemia	indication
Synergy for Citrobacter Meningitis	indication
Synergy for Serratia Meningitis	indication
Synergy for Enterobacter Meningitis	indication
Klebsiella Septicemia	indication
Synergy for Escherichia Coli Meningitis	indication
Necrotizing enterocolitis in fetus OR newborn	off-label use	2707005
Pyrexia of unknown origin	off-label use	7520000
Ecthyma gangrenosum	off-label use	17732003
Enteric campylobacteriosis	off-label use	18081009
Pseudotuberculosis	off-label use	36753006
Plague	off-label use	58750007	DOID:3482
Infection by Yersinia enterocolitica	off-label use	80960004
Infection by Campylobacter fetus	off-label use	111835002
Listeria Monocytogenes Septicemia	off-label use
Pseudomonas Respiratory Tract Infection in Cystic Fibrosis	off-label use
Synergy for Prevention of Enterococcal Endocarditis	off-label use
Prevention of Perioperative Infection	off-label use
Synergy for Streptococcal Endocarditis	off-label use
Synergy for Enterococcal Endocarditis	off-label use
Synergy for Listeria Monocytogenes Septicemia	off-label use
Synergy for Enterococcal Infections	off-label use
Ocular hypertension	contraindication	4210003	DOID:9282
Hypocalcemia	contraindication	5291005
Herpes simplex keratitis	contraindication	9389005
Herpes simplex dendritic keratitis	contraindication	29943008
Fungal infection of eye	contraindication	31194008
Parkinsonism	contraindication	32798002
Dehydration	contraindication	34095006
Severe myopia	contraindication	34187009
Tuberculosis of eye	contraindication	49107007
Tinnitus	contraindication	60862001
Diabetes mellitus	contraindication	73211009	DOID:9351
Open-angle glaucoma	contraindication	84494001	DOID:1067
Krukenberg spindle	contraindication	85430004
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Eye infection	contraindication	128351009
Bacterial infection of eye	contraindication	128984004
Pregnancy, function	contraindication	289908002
Viral eye infection	contraindication	312132001
Vaccinia keratitis	contraindication	397552005
Vertigo	contraindication	399153001
Denuded skin	contraindication	418242004
Infant Botulism	contraindication
Disorder of the 8th Cranial Nerve	contraindication
Gentamicin Toxicity	contraindication

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Urinary tract infections	Indication
Cats	Respiratory tract infections	Indication
Cats	Skin and soft tissue infections	Indication
Cats	Supportive therapy for secondary bacterial infections associated with panleucopenia	Indication
Cats	Conjunctivitis	Indication
Cattle	Infectious bovine keratoconjunctivitis associated with Moraxella bovis	Indication
Chickens	Prevention of early mortality caused by Escherichia coli	Indication
Chickens	Prevention of early mortality caused by Salmonella typhimurium	Indication
Chickens	Prevention of early mortality caused by Pseudomonas aeruginosa	Indication
Dogs	External eye infections	Indication
Dogs	Acute and chronic otitis externa caused by bacteria	Indication
Dogs	Urinary tract infections	Indication
Dogs	Respiratory tract infections	Indication
Dogs	Skin and soft tissue infections	Indication
Horses	Uterus infections	Indication
Horses	Improving conception in mares with uterine infections	Indication
Swine	Dysentery associated with Brachyspira hyodysenteriae	Indication
Swine	PorcinEscherichia colibacillosis caused by Escherichia coli	Indication
Turkeys	Prevention of early mortality caused by Arizona paracolon infections	Indication
Turkeys	Reduction or elimination of Arizona hinshawii	Indication
Turkeys	Reduction or elimination of Salmonella st paul	Indication
Turkeys	Reduction or elimination of Mycoplasma meleagris	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Gentocin Durafilm	Intervet Inc.	2
Gentocin Solution	Intervet Inc.	1
Gentocin Solution	Intervet Inc.	1
Gentocin Otic Solution	Intervet Inc.	2
Garacin	Intervet Inc.	1
Garasol Solution	Intervet Inc.	1
Gentocin Ophthalmic Ointment	Intervet Inc.	1
Gentocin Ophthalmic Solution	Intervet Inc.	1
Garasol Injection	Intervet Inc.	1
Garacin Piglet Injection	Intervet Inc.	1
Topagen Ointment	Intervet Inc.	2
Gentocin (Garacin) Pig Pump Oral Solution	Intervet Inc.	1
Gentocin Pink Eye Spray	Intervet Inc.	1
Gentocin Topical Spray	Intervet Inc.	2
Garacin Soluble Powder	Intervet Inc.	1
Gentamicin Sulfate Inj. Sol.	Cronus Pharma Specialities India Private Limited	1
Otomax	Intervet Inc.	3
Mometamax Otic Suspension	Intervet Inc.	3
Easotic	Virbac AH Inc.	3
Gentamicin Sulfate Solution 100 mg/ml	Cronus Pharma Specialities India Private Limited	1
Gentamicin Sulfate Solution, Legacy Sterile Solution	Huvepharma EOOD	1
Gentaglyde Solution	Zoetis Inc.	1
Gentamex 100	Bimeda Animal Health Limited	1
GentaMax 100	Elanco US Inc.	1
Genta-Ject, Gentamicin Sulfate Injection	Huvepharma EOOD	1
Gentamicin Sulfate Pig Pump Oral Solution	Huvepharma EOOD	1
VET BETA-GEN	Med-Pharmex Inc.	2
GEN-GARD	Huvepharma EOOD	1
Betagen Topical Spray	Med-Pharmex Inc.	2
GENTORAL	Med-Pharmex Inc.	1
Gentasol	Med-Pharmex Inc.	1
Tri-Otic Ointment	Med-Pharmex Inc.	3
Vetro-Gen Veterinary Ophthalmic Ointment	Dechra Veterinary Products LLC	1
Vetro-Max	Fougera Pharmaceuticals Inc.	3
GBC Ointment	Cronus Pharma Specialities India Private Limited	3
GB Topical Spray	Dechra Veterinary Products LLC	2
Gentamicin Piglet Injection	Sparhawk Laboratories Inc.	1
Gentamicin Sulfate Solution	Sparhawk Laboratories Inc.	1
Gentamicin Sulfate Topical Spray	First Priority Inc.	2
Gentamicin Topical Spray	Sparhawk Laboratories Inc.	2
GentaMed-P for Poultry Injection	Bimeda Animal Health Limited	1
GentaMed	Bimeda Animal Health Limited	1
Mometavet	Med-Pharmex Inc.	3
Gentamicin Sulfate Ophthalmic Solution	Akorn Animal Health Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Dihydrofolate reductase	Enzyme	P00374	DYR_HUMAN		IC50	4.74		CHEMBL
Transient receptor potential cation channel subfamily V member 5	Ion channel	Q9NQA5	TRPV5_HUMAN	INHIBITOR	IC50	6		IUPHAR
Dihydrofolate reductase	Enzyme		DYR_BOVIN		IC50	4.60		CHEMBL
Transient receptor potential cation channel subfamily A member 1	Ion channel		TRPA1_MOUSE	GATING INHIBITOR	IC50	5.20		IUPHAR

External reference:

ID	Source
4019765	VUID
N0000179542	NUI
D01063	KEGG_DRUG
1403-66-3	SECONDARY_CAS_RN
4018210	VANDF
4019765	VANDF
C3854019	UMLSCUI
CHEBI:17833	CHEBI
CHEMBL6067485	ChEMBL_ID
CHEMBL6067484	ChEMBL_ID
D005839	MESH_DESCRIPTOR_UI
DB00798	DRUGBANK_ID
2427	IUPHAR_LIGAND_ID
1617	INN_ID
T6Z9V48IKG	UNII
3467	PUBCHEM_CID
1596450	RXNORM
228599	MMSL
4779	MMSL
d00014	MMSL
002778	NDDF
004898	NDDF
2249001	SNOMEDCT_US
387321007	SNOMEDCT_US
57752001	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Gentamicin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9128	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	16 sections
Gentamicin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9129	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	16 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0503	INJECTION, SOLUTION	80 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0505	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0507	INJECTION, SOLUTION	60 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0509	INJECTION, SOLUTION	80 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0511	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9865	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	13 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9865	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	13 sections
Gentamicin	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9866	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	13 sections
Gentamicin	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9866	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	13 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1207	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	17 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0682	OINTMENT	1 mg	TOPICAL	ANDA	9 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0683	CREAM	1 mg	TOPICAL	ANDA	9 sections
GENTAMICIN SULFATE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-107	CREAM	1 mg	TOPICAL	ANDA	10 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	17478-283	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	18 sections
Gentak	HUMAN PRESCRIPTION DRUG LABEL	1	17478-284	OINTMENT	3 mg	OPHTHALMIC	ANDA	18 sections
GENTAMICIN SULFATE	HUMAN PRESCRIPTION DRUG LABEL	1	21695-187	SOLUTION	3 mg	OPHTHALMIC	ANDA	15 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	24208-580	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	14 sections
GENTAMICIN SULFATE	HUMAN PRESCRIPTION DRUG LABEL	1	33261-604	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	17 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	45802-046	OINTMENT	1 mg	TOPICAL	ANDA	11 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	45802-056	CREAM	1 mg	TOPICAL	ANDA	11 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	45865-672	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	15 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0569	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	14 sections
Gentak	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4770	OINTMENT	3 mg	OPHTHALMIC	ANDA	17 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	50436-6752	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	15 sections
GENTAMICIN	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1508	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	14 sections
GENTAMICIN SULFATE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1597	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	13 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	52565-085	CREAM	1 mg	TOPICAL	ANDA	11 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	52565-090	OINTMENT	1 mg	TOPICAL	ANDA	11 sections