gentamicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
aminoglycosides, antibiotics obtained from various Micromonospora	4265	1405-41-0

Description:

Molecule	Description
Synonyms: gentamicin sulfate gentamicin alcomicin gentacin gentamicine sulfate	A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS. Molecular weight: 1390.73 Formula: C60H123N15O21 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

gentamicin sulfate
gentamicin
alcomicin
gentacin
gentamicine sulfate

A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Molecular weight: 1390.73
Formula: C60H123N15O21
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.24	g	P

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	6.28 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	0.33 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	1 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	4.70 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
June 19, 1970	FDA	SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	583.40	14.27	542	17122	227516	50359944
Drug reaction with eosinophilia and systemic symptoms	243.63	14.27	141	17523	28283	50559177
Renal tubular necrosis	160.56	14.27	76	17588	10092	50577368
Multiple organ dysfunction syndrome	154.16	14.27	133	17531	50204	50537256
Toxic epidermal necrolysis	148.31	14.27	92	17572	20900	50566560
Peritonitis bacterial	112.77	14.27	47	17617	4614	50582846
Renal failure	108.06	14.27	158	17506	106475	50480985
Pathogen resistance	103.76	14.27	47	17617	5642	50581818
Septic shock	96.24	14.27	109	17555	57066	50530394
Ototoxicity	87.59	14.27	27	17637	1100	50586360
Anaphylactic reaction	85.82	14.27	100	17564	53955	50533505
Sepsis	82.36	14.27	158	17506	132767	50454693
Bartter's syndrome	82.00	14.27	13	17651	12	50587448
Peritonitis	80.40	14.27	56	17608	15430	50572030
Eosinophilia	75.43	14.27	58	17606	18594	50568866
Toxic skin eruption	73.64	14.27	47	17617	11204	50576256
Nephropathy toxic	71.85	14.27	41	17623	7988	50579472
Pyrexia	68.54	14.27	288	17376	379915	50207545
Shock haemorrhagic	62.55	14.27	38	17626	8306	50579154
Antibiotic level above therapeutic	61.71	14.27	15	17649	245	50587215
Abdominal discomfort	59.41	14.27	6	17658	231635	50355825
Tubulointerstitial nephritis	56.53	14.27	45	17619	15166	50572294
Drug resistance	53.71	14.27	48	17616	18941	50568519
Mucosal inflammation	51.93	14.27	67	17597	40075	50547385
Stevens-Johnson syndrome	51.89	14.27	50	17614	21702	50565758
Neutropenic sepsis	50.76	14.27	41	17623	14106	50573354
Drug intolerance	50.55	14.27	8	17656	219096	50368364
Joint swelling	50.19	14.27	12	17652	245274	50342186
Oliguria	48.08	14.27	32	17632	8184	50579276
Rheumatoid arthritis	47.63	14.27	7	17657	202543	50384917
Oropharyngeal oedema	46.89	14.27	12	17652	244	50587216
Endocarditis	45.48	14.27	26	17638	5081	50582379
Vestibular disorder	45.46	14.27	17	17647	1252	50586208
Headache	45.14	14.27	67	17597	506468	50080992
Fall	44.97	14.27	31	17633	334901	50252559
Metabolic alkalosis	44.91	14.27	21	17643	2710	50584750
Candida infection	43.25	14.27	47	17617	23476	50563984
Linear IgA disease	42.03	14.27	16	17648	1238	50586222
Intraventricular haemorrhage neonatal	41.81	14.27	10	17654	152	50587308
Arthritis bacterial	40.57	14.27	25	17639	5604	50581856
Nasopharyngitis	40.33	14.27	9	17655	192918	50394542
Systemic lupus erythematosus	37.76	14.27	3	17661	140619	50446841
Umbilical erythema	37.29	14.27	8	17656	72	50587388
Anuria	37.01	14.27	31	17633	11213	50576247
Abscess neck	36.68	14.27	12	17652	594	50586866
Drug interaction	36.43	14.27	152	17512	199469	50387991
Product dose omission issue	35.66	14.27	10	17654	183828	50403632
Mental status changes postoperative	35.60	14.27	9	17655	174	50587286
Renal injury	35.30	14.27	27	17637	8584	50578876
Fatigue	35.26	14.27	128	17536	707473	49879987
Excessive eye blinking	35.08	14.27	13	17651	933	50586527
Confusion postoperative	34.67	14.27	9	17655	194	50587266
Neutropenia	33.80	14.27	121	17543	147844	50439616
Liver abscess	33.77	14.27	17	17647	2576	50584884
Death neonatal	33.48	14.27	9	17655	223	50587237
Sepsis syndrome	33.22	14.27	12	17652	801	50586659
Disseminated intravascular coagulation	32.84	14.27	35	17629	17100	50570360
Pancytopenia	32.75	14.27	83	17581	83947	50503513
Noninfectious peritonitis	32.72	14.27	8	17656	134	50587326
Haemodynamic instability	32.54	14.27	25	17639	7999	50579461
Hyperchlorhydria	32.29	14.27	14	17650	1514	50585946
Renal impairment	31.88	14.27	77	17587	75584	50511876
Skin test positive	31.84	14.27	11	17653	644	50586816
Renal tubular disorder	31.81	14.27	16	17648	2421	50585039
Acute respiratory distress syndrome	31.75	14.27	38	17626	21061	50566399
Tendon necrosis	31.34	14.27	5	17659	5	50587455
Enterococcal infection	31.33	14.27	23	17641	6875	50580585
Contraindicated product administered	31.02	14.27	7	17657	148951	50438509
Deafness neurosensory	29.94	14.27	19	17645	4482	50582978
Arthropathy	29.87	14.27	9	17655	157897	50429563
Escherichia infection	29.64	14.27	27	17637	10914	50576546
Crystalluria	28.88	14.27	9	17655	380	50587080
Rash erythematous	28.72	14.27	47	17617	34805	50552655
Weight increased	27.98	14.27	18	17646	201873	50385587
Rash maculo-papular	27.68	14.27	40	17624	26601	50560859
Cholestasis	27.66	14.27	39	17625	25362	50562098
Procedural hypertension	27.37	14.27	8	17656	271	50587189
Therapeutic product effect decreased	27.13	14.27	7	17657	136043	50451417
Thrombocytopenia	27.12	14.27	102	17562	127571	50459889
Retinal infarction	27.05	14.27	6	17658	64	50587396
Lactic acidosis	26.17	14.27	44	17620	33311	50554149
Folate deficiency	26.00	14.27	13	17651	1942	50585518
Application site scab	25.61	14.27	7	17657	185	50587275
Blood phosphorus decreased	25.22	14.27	16	17648	3773	50583687
Lemierre syndrome	25.10	14.27	6	17658	91	50587369
Toxic shock syndrome streptococcal	24.86	14.27	6	17658	95	50587365
Premature baby	24.32	14.27	31	17633	18306	50569154
Pain	24.21	14.27	112	17552	578791	50008669
Puerperal pyrexia	24.18	14.27	5	17659	37	50587423
Peripheral swelling	23.91	14.27	22	17642	205914	50381546
Premature delivery	23.82	14.27	35	17629	23628	50563832
Injection site pain	23.55	14.27	5	17659	111019	50476441
Musculoskeletal stiffness	23.10	14.27	8	17656	128473	50458987
Agranulocytosis	22.02	14.27	32	17632	21389	50566071
Drug level increased	21.60	14.27	30	17634	19238	50568222
Morganella infection	21.55	14.27	8	17656	577	50586883
Guillain-Barre syndrome	21.45	14.27	14	17650	3463	50583997
Endocarditis bacterial	21.41	14.27	8	17656	588	50586872
Arthralgia	21.34	14.27	80	17584	438622	50148838
Foetal exposure during pregnancy	21.34	14.27	36	17628	27323	50560137
Macroglossia	20.88	14.27	8	17656	630	50586830
Blood creatinine increased	20.65	14.27	66	17598	76094	50511366
Tachycardia	20.59	14.27	79	17585	99684	50487776
Purpura	20.34	14.27	21	17643	9890	50577570
Kussmaul respiration	19.86	14.27	6	17658	228	50587232
Pain in extremity	19.77	14.27	41	17623	272824	50314636
Neurotoxicity	19.68	14.27	25	17639	14715	50572745
Therapeutic product effect incomplete	19.66	14.27	4	17660	91511	50495949
Inflammatory marker increased	19.51	14.27	16	17648	5618	50581842
Gastrointestinal haemorrhage	19.38	14.27	63	17601	73258	50514202
Hypoglossal nerve paresis	19.30	14.27	5	17659	107	50587353
Peritoneal dialysis complication	19.17	14.27	9	17655	1172	50586288
Anaphylactic shock	19.12	14.27	29	17635	20126	50567334
Discomfort	19.05	14.27	7	17657	108373	50479087
Septic embolus	18.98	14.27	8	17656	807	50586653
Tonsillitis bacterial	18.75	14.27	5	17659	120	50587340
Anal ulcer	18.58	14.27	7	17657	526	50586934
Infusion site necrosis	18.55	14.27	4	17660	37	50587423
Spinal subdural haematoma	18.52	14.27	5	17659	126	50587334
Nausea	18.35	14.27	158	17506	705240	49882220
Pancreatitis haemorrhagic	18.34	14.27	6	17658	297	50587163
Foetal heart rate decreased	17.95	14.27	5	17659	142	50587318
Haemolytic anaemia	17.84	14.27	19	17645	9273	50578187
Feeling abnormal	17.63	14.27	11	17653	125481	50461979
Exfoliative rash	17.63	14.27	11	17653	2519	50584941
Therapeutic drug monitoring analysis incorrectly performed	17.62	14.27	5	17659	152	50587308
Hydrops foetalis	17.57	14.27	6	17658	339	50587121
Necrosis	17.57	14.27	14	17650	4722	50582738
Human herpesvirus 6 infection	17.33	14.27	11	17653	2595	50584865
Shock	17.22	14.27	28	17636	20622	50566838
Urogenital disorder	17.17	14.27	4	17660	54	50587406
Drug eruption	17.02	14.27	30	17634	23576	50563884
Alopecia	16.77	14.27	38	17626	245009	50342451
Hypocalcaemia	16.71	14.27	32	17632	26784	50560676
Insomnia	16.63	14.27	22	17642	174843	50412617
Dermatitis exfoliative	16.56	14.27	14	17650	5128	50582332
Umbilical cord around neck	16.48	14.27	5	17659	193	50587267
Infusion related reaction	16.47	14.27	21	17643	169536	50417924
Staphylococcal sepsis	16.45	14.27	16	17648	7020	50580440
Neonatal cardiac failure	16.27	14.27	3	17661	11	50587449
Pyroglutamic acidosis	16.11	14.27	6	17658	437	50587023
Systemic infection	16.10	14.27	10	17654	2273	50585187
Haemodialysis	15.88	14.27	17	17647	8345	50579115
Hyperleukocytosis	15.84	14.27	6	17658	458	50587002
Staphylococcal infection	15.80	14.27	37	17627	35579	50551881
Device related infection	15.80	14.27	27	17637	20708	50566752
Geotrichum infection	15.76	14.27	6	17658	464	50586996
Bacterial disease carrier	15.74	14.27	7	17657	804	50586656
Immune reconstitution inflammatory syndrome	15.71	14.27	14	17650	5502	50581958
Sinusitis	15.67	14.27	22	17642	170536	50416924
Toxic shock syndrome	15.49	14.27	6	17658	486	50586974
Bronchopulmonary aspergillosis	15.42	14.27	16	17648	7576	50579884
Meconium in amniotic fluid	15.33	14.27	5	17659	245	50587215
Candida test positive	15.32	14.27	7	17657	857	50586603
Hypoperfusion	15.24	14.27	8	17656	1322	50586138
Muscle spasms	15.05	14.27	13	17651	125540	50461920
Sudden visual loss	14.91	14.27	3	17661	19	50587441
Renal cortical necrosis	14.81	14.27	4	17660	101	50587359
Epstein-Barr virus test positive	14.73	14.27	6	17658	555	50586905
Neonatal disorder	14.72	14.27	6	17658	556	50586904
Neuromuscular blockade	14.60	14.27	5	17659	285	50587175
Weight decreased	14.58	14.27	35	17629	221210	50366250
Hepatic cytolysis	14.56	14.27	16	17648	8087	50579373
Nephrocalcinosis	14.52	14.27	7	17657	967	50586493
Hypotonia neonatal	14.36	14.27	7	17657	990	50586470
Pulmonary necrosis	14.28	14.27	4	17660	116	50587344

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	468.92	14.20	693	17885	264574	29291375
Drug reaction with eosinophilia and systemic symptoms	211.44	14.20	160	18418	27832	29528117
Pathogen resistance	185.26	14.20	94	18484	8022	29547927
Renal tubular necrosis	164.76	14.20	106	18472	14209	29541740
Eosinophilia	113.28	14.20	101	18477	22060	29533889
Rash maculo-papular	96.00	14.20	96	18482	24193	29531756
Drug resistance	92.33	14.20	89	18489	21451	29534498
Crystalluria	89.36	14.20	25	18553	390	29555559
Endocarditis	80.10	14.20	48	18530	5668	29550281
Ototoxicity	76.99	14.20	31	18547	1534	29554415
Nephropathy toxic	75.68	14.20	59	18519	10697	29545252
Tubulointerstitial nephritis	68.35	14.20	69	18509	17574	29538375
Anaphylactic reaction	66.07	14.20	84	18494	27489	29528460
Spinal muscular atrophy	65.05	14.20	18	18560	269	29555680
Multiple organ dysfunction syndrome	64.24	14.20	130	18448	62986	29492963
Fatigue	61.77	14.20	65	18513	316756	29239193
Peritonitis bacterial	59.79	14.20	40	18538	5716	29550233
Pyrexia	59.57	14.20	345	18233	287277	29268672
Pneumococcal sepsis	56.28	14.20	21	18557	845	29555104
Klebsiella infection	51.02	14.20	40	18538	7309	29548640
Renal impairment	50.42	14.20	138	18440	81195	29474754
Septic shock	50.11	14.20	117	18461	62443	29493506
Vestibular disorder	48.83	14.20	20	18558	1034	29554915
Linear IgA disease	48.71	14.20	22	18556	1447	29554502
Renal failure	48.36	14.20	174	18404	118425	29437524
Toxic epidermal necrolysis	46.18	14.20	57	18521	18096	29537853
Respiratory tract infection bacterial	44.02	14.20	16	18562	597	29555352
Fall	43.48	14.20	29	18549	177149	29378800
Toxic skin eruption	43.08	14.20	41	18537	9716	29546233
Purpura	43.08	14.20	40	18538	9192	29546757
Antimicrobial susceptibility test resistant	43.03	14.20	13	18565	269	29555680
Death	42.74	14.20	95	18483	341989	29213960
Increased bronchial secretion	41.06	14.20	20	18558	1561	29554388
Cardiac valve vegetation	40.36	14.20	14	18564	455	29555494
Asthenia	39.83	14.20	46	18532	215204	29340745
Neonatal disorder	39.82	14.20	16	18562	787	29555162
Deafness neurosensory	39.66	14.20	23	18555	2555	29553394
Product dose omission issue	38.52	14.20	7	18571	96376	29459573
Auditory neuropathy spectrum disorder	38.24	14.20	6	18572	0	29555949
Sputum increased	37.31	14.20	20	18558	1907	29554042
Antibiotic level above therapeutic	37.29	14.20	11	18567	209	29555740
Acute generalised exanthematous pustulosis	35.79	14.20	29	18549	5554	29550395
Agranulocytosis	35.22	14.20	53	18525	20287	29535662
Sepsis	33.97	14.20	178	18400	142504	29413445
Cerebral ischaemia	33.17	14.20	28	18550	5675	29550274
Cholestasis	30.90	14.20	54	18524	23408	29532541
Peritonitis	30.61	14.20	42	18536	14782	29541167
Dizziness	30.48	14.20	45	18533	189639	29366310
Pulmonary haemorrhage	30.09	14.20	33	18545	9237	29546712
Ischaemic cerebral infarction	30.02	14.20	14	18564	991	29554958
Nausea	29.41	14.20	89	18489	289166	29266783
Chest X-ray abnormal	29.29	14.20	22	18556	3772	29552177
Infective aneurysm	28.37	14.20	11	18567	492	29555457
Disease complication	28.25	14.20	18	18560	2368	29553581
Motor neurone disease	28.04	14.20	10	18568	353	29555596
Hypoprothrombinaemia	27.70	14.20	10	18568	366	29555583
Metabolic disorder	27.58	14.20	21	18557	3674	29552275
Resuscitation	27.53	14.20	14	18564	1198	29554751
Mucormycosis	27.31	14.20	24	18554	5134	29550815
Necrotising colitis	26.92	14.20	13	18565	995	29554954
Haemodynamic instability	26.65	14.20	29	18549	8044	29547905
Nutritional condition abnormal	26.62	14.20	10	18568	410	29555539
Insomnia	25.38	14.20	12	18566	88749	29467200
Lower respiratory tract infection bacterial	25.17	14.20	9	18569	320	29555629
Listeriosis	25.01	14.20	12	18566	906	29555043
Infusion site induration	24.97	14.20	8	18570	202	29555747
Bradycardia neonatal	24.74	14.20	12	18566	928	29555021
Fungaemia	24.70	14.20	16	18562	2165	29553784
Stoma closure	24.68	14.20	7	18571	115	29555834
Headache	24.48	14.20	45	18533	173962	29381987
Thrombocytopenia	24.12	14.20	156	18422	134667	29421282
Brain injury	24.02	14.20	23	18555	5489	29550460
Sepsis neonatal	23.64	14.20	8	18570	241	29555708
Petechiae	23.56	14.20	28	18550	8543	29547406
Nosocomial infection	23.39	14.20	12	18566	1046	29554903
Hepatocellular injury	23.07	14.20	45	18533	21198	29534751
Bronchial disorder	22.34	14.20	12	18566	1149	29554800
ADAMTS13 activity decreased	22.25	14.20	6	18572	81	29555868
Pseudomembranous colitis	22.17	14.20	16	18562	2581	29553368
Lung consolidation	21.90	14.20	21	18557	5022	29550927
Lymphocyte morphology abnormal	21.85	14.20	9	18569	472	29555477
Acinetobacter infection	20.90	14.20	11	18567	1011	29554938
Arthralgia	20.63	14.20	35	18543	139582	29416367
Staphylococcal infection	20.51	14.20	52	18526	29188	29526761
Bacillus infection	20.34	14.20	7	18571	222	29555727
Intestinal ischaemia	20.30	14.20	23	18555	6669	29549280
Neonatal hypoxia	20.28	14.20	8	18570	375	29555574
Haemodialysis	20.24	14.20	28	18550	9926	29546023
Jarisch-Herxheimer reaction	20.17	14.20	8	18570	380	29555569
Aortic valve disease	20.04	14.20	11	18567	1099	29554850
Oliguria	20.02	14.20	24	18554	7388	29548561
Red blood cell schistocytes present	19.96	14.20	7	18571	235	29555714
Lymphadenectomy	19.96	14.20	7	18571	235	29555714
Intraventricular haemorrhage neonatal	19.74	14.20	7	18571	243	29555706
Clostridium difficile colitis	19.50	14.20	32	18546	13180	29542769
Blood alkaline phosphatase increased	19.39	14.20	50	18528	28356	29527593
Herpes zoster reactivation	19.21	14.20	7	18571	263	29555686
Stenotrophomonas test positive	19.14	14.20	7	18571	266	29555683
Drug ineffective	19.13	14.20	327	18251	362843	29193106
Haemorrhage neonatal	19.12	14.20	3	18575	0	29555949
Endocarditis candida	19.08	14.20	5	18573	60	29555889
Motor dysfunction	19.05	14.20	21	18557	5909	29550040
Hypotension	19.02	14.20	196	18382	194158	29361791
Hypersensitivity vasculitis	18.96	14.20	16	18562	3241	29552708
Antineutrophil cytoplasmic antibody	18.87	14.20	4	18574	17	29555932
Mast cell degranulation present	18.86	14.20	5	18573	63	29555886
Application site scab	18.71	14.20	5	18573	65	29555884
Eosinophilic pneumonia acute	18.61	14.20	8	18570	467	29555482
Chondrocalcinosis	18.59	14.20	7	18571	289	29555660
Respiratory distress	18.41	14.20	53	18525	32053	29523896
Aortic valve incompetence	18.31	14.20	19	18559	4994	29550955
Rash morbilliform	18.24	14.20	14	18564	2479	29553470
Premature baby	18.03	14.20	36	18542	17244	29538705
Condition aggravated	18.03	14.20	155	18423	146140	29409809
Rash erythematous	17.98	14.20	41	18537	21521	29534428
Cardiac valve abscess	17.87	14.20	4	18574	23	29555926
Haemophagocytic lymphohistiocytosis	17.65	14.20	27	18551	10477	29545472
Staphylococcal bacteraemia	17.63	14.20	22	18556	7057	29548892
Scrotal pain	17.52	14.20	9	18569	787	29555162
Aspergillus infection	17.50	14.20	27	18551	10554	29545395
Localised oedema	17.34	14.20	15	18563	3141	29552808
Cardiac arrest neonatal	17.19	14.20	4	18574	28	29555921
Nasopharyngitis	17.15	14.20	8	18570	59657	29496292
Stupor	17.05	14.20	14	18564	2730	29553219
Depression	17.04	14.20	17	18561	85130	29470819
Neuropathy peripheral	16.89	14.20	12	18566	71015	29484934
CD4 lymphocytes increased	16.76	14.20	6	18572	214	29555735
Injury	16.75	14.20	37	18541	19009	29536940
Cough	16.74	14.20	34	18544	126693	29429256
Dry gangrene	16.70	14.20	7	18571	384	29555565
Hyperaldosteronism	16.61	14.20	5	18573	102	29555847
Fixed eruption	16.59	14.20	10	18568	1192	29554757
Pain	16.49	14.20	54	18524	171378	29384571
Weight decreased	16.34	14.20	45	18533	150860	29405089
Trichosporon infection	16.33	14.20	8	18570	632	29555317
Blood creatinine increased	16.14	14.20	100	18478	85002	29470947
Cross sensitivity reaction	16.14	14.20	10	18568	1252	29554697
Coronary artery disease	16.03	14.20	4	18574	44186	29511763
Dermatitis contact	16.00	14.20	14	18564	2978	29552971
Extravasation	15.89	14.20	11	18567	1661	29554288
Arthritis reactive	15.86	14.20	6	18572	251	29555698
Application site erythema	15.82	14.20	12	18566	2087	29553862
Weight increased	15.69	14.20	15	18563	76652	29479297
Hypertransaminasaemia	15.63	14.20	15	18563	3591	29552358
Disseminated intravascular coagulation	15.57	14.20	37	18541	19943	29536006
Reticulocytosis	15.50	14.20	6	18572	267	29555682
Muscle spasms	15.47	14.20	11	18567	65071	29490878
Cerebellar atrophy	15.21	14.20	7	18571	481	29555468
Metabolic acidosis	15.08	14.20	55	18523	37607	29518342
Leukocyturia	15.03	14.20	7	18571	494	29555455
Renal tubular disorder	15.01	14.20	16	18562	4336	29551613
Pulmonary valve disease	14.99	14.20	6	18572	292	29555657
HIV associated nephropathy	14.99	14.20	6	18572	292	29555657
Cardio-respiratory arrest neonatal	14.97	14.20	3	18575	9	29555940
Clostridium difficile infection	14.93	14.20	32	18546	16109	29539840
Abdominal pain upper	14.90	14.20	10	18568	60983	29494966
Myeloma cast nephropathy	14.90	14.20	4	18574	53	29555896
Scoliosis	14.85	14.20	12	18566	2288	29553661
Diarrhoea	14.71	14.20	136	18442	332562	29223387
Arthritis infective	14.67	14.20	13	18565	2811	29553138
Arteritis	14.65	14.20	6	18572	310	29555639
Application site vesicles	14.51	14.20	7	18571	535	29555414
Malignant neoplasm progression	14.49	14.20	15	18563	73844	29482105
Fungal skin infection	14.41	14.20	12	18566	2386	29553563
Neonatal candida infection	14.30	14.20	3	18575	12	29555937
Chronic obstructive pulmonary disease	14.30	14.20	4	18574	40951	29514998
Neonatal tachypnoea	14.25	14.20	5	18573	168	29555781

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	1004.90	12.68	1146	29596	448094	64019896
Drug reaction with eosinophilia and systemic symptoms	428.49	12.68	286	30456	53931	64414059
Renal tubular necrosis	286.13	12.68	160	30582	21950	64446040
Pathogen resistance	246.11	12.68	120	30622	12423	64455567
Eosinophilia	189.49	12.68	152	30590	37924	64430066
Ototoxicity	163.73	12.68	58	30684	2665	64465325
Multiple organ dysfunction syndrome	160.70	12.68	219	30523	101194	64366796
Toxic epidermal necrolysis	155.08	12.68	134	30608	37032	64430958
Peritonitis bacterial	135.11	12.68	72	30670	8971	64459019
Anaphylactic reaction	131.71	12.68	163	30579	68501	64399489
Nephropathy toxic	130.09	12.68	89	30653	17425	64450565
Rash maculo-papular	122.89	12.68	131	30611	46895	64421095
Antibiotic level above therapeutic	118.59	12.68	32	30710	581	64467409
Crystalluria	117.52	12.68	34	30708	804	64467186
Septic shock	117.29	12.68	193	30549	105244	64362746
Pyrexia	116.57	12.68	550	30192	558094	63909896
Renal failure	115.15	12.68	262	30480	181426	64286564
Tubulointerstitial nephritis	112.16	12.68	103	30639	30806	64437184
Endocarditis	110.87	12.68	64	30678	9314	64458676
Drug resistance	104.71	12.68	105	30637	34997	64432993
Toxic skin eruption	102.37	12.68	80	30662	19204	64448786
Vestibular disorder	101.53	12.68	39	30703	2254	64465736
Completed suicide	93.42	12.68	3	30739	224411	64243579
Linear IgA disease	87.61	12.68	37	30705	2737	64465253
Bartter's syndrome	84.43	12.68	14	30728	12	64467978
Fall	81.45	12.68	49	30693	416777	64051213
Fatigue	78.44	12.68	149	30593	748581	63719409
Renal impairment	78.15	12.68	188	30554	134829	64333161
Sepsis	76.93	12.68	263	30479	230078	64237912
Peritonitis	76.74	12.68	76	30666	24947	64443043
Product dose omission issue	67.85	12.68	7	30735	194740	64273250
Headache	66.94	12.68	93	30649	529374	63938616
Purpura	65.55	12.68	59	30683	17187	64450803
Spinal muscular atrophy	64.72	12.68	17	30725	277	64467713
Drug intolerance	62.38	12.68	8	30734	187984	64280006
Deafness neurosensory	58.55	12.68	37	30705	6337	64461653
Rheumatoid arthritis	56.98	12.68	6	30736	164288	64303702
Joint swelling	53.44	12.68	18	30724	215364	64252626
Nasopharyngitis	52.98	12.68	14	30728	196059	64271931
Stevens-Johnson syndrome	52.72	12.68	73	30669	34176	64433814
Clostridium difficile infection	51.11	12.68	74	30668	36089	64431901
Drug abuse	51.01	12.68	3	30739	132371	64335619
Haemodynamic instability	50.82	12.68	48	30694	14864	64453126
Cardiac valve vegetation	50.64	12.68	18	30724	835	64467155
Cholestasis	49.65	12.68	82	30660	44790	64423200
Agranulocytosis	49.39	12.68	75	30667	38154	64429836
Weight increased	49.27	12.68	20	30722	213328	64254662
Pain	48.84	12.68	121	30621	553390	63914600
Pneumococcal sepsis	46.61	12.68	19	30723	1285	64466705
Renal injury	45.72	12.68	46	30696	15383	64452607
Noninfectious peritonitis	43.52	12.68	12	30730	237	64467753
Oropharyngeal oedema	43.23	12.68	12	30730	243	64467747
Shock haemorrhagic	42.47	12.68	46	30696	16745	64451245
Antimicrobial susceptibility test resistant	42.00	12.68	12	30730	271	64467719
Klebsiella infection	41.95	12.68	41	30701	13240	64454750
Metabolic alkalosis	41.68	12.68	25	30717	3903	64464087
Respiratory tract infection bacterial	40.05	12.68	15	30727	808	64467182
Acute generalised exanthematous pustulosis	39.99	12.68	41	30701	14017	64453973
Abdominal discomfort	39.09	12.68	19	30723	182303	64285687
Nausea	38.96	12.68	218	30524	785582	63682408
Renal tubular disorder	38.81	12.68	28	30714	5959	64462031
Arthralgia	37.94	12.68	98	30644	442162	64025828
Asthenia	37.37	12.68	94	30648	427950	64040040
Oliguria	36.99	12.68	40	30702	14536	64453454
Arthritis bacterial	36.24	12.68	30	30712	7809	64460181
Petechiae	35.33	12.68	44	30698	18582	64449408
Blood creatinine increased	34.40	12.68	142	30600	135640	64332350
Sepsis syndrome	33.64	12.68	15	30727	1266	64466724
Haemodialysis	33.45	12.68	41	30701	17036	64450954
Rash erythematous	32.82	12.68	72	30670	48561	64419429
Abdominal pain upper	32.16	12.68	22	30720	175008	64292982
Infective aneurysm	32.09	12.68	13	30729	865	64467125
Arthropathy	31.98	12.68	9	30733	120958	64347032
Pain in extremity	31.86	12.68	60	30682	303025	64164965
Anaphylactic shock	31.65	12.68	54	30688	30274	64437716
Therapeutic product effect decreased	31.60	12.68	8	30734	115343	64352647
Peripheral swelling	31.40	12.68	32	30710	209121	64258869
Aortic valve incompetence	30.76	12.68	28	30714	8273	64459717
Therapeutic product effect incomplete	30.71	12.68	6	30736	103476	64364514
Hypotension	30.44	12.68	296	30446	380678	64087312
Candida infection	30.26	12.68	54	30688	31365	64436625
Tachycardia	30.04	12.68	146	30596	149433	64318557
Enterococcal infection	29.96	12.68	35	30707	13831	64454159
Increased bronchial secretion	29.92	12.68	18	30724	2824	64465166
Tendon necrosis	29.78	12.68	5	30737	5	64467985
Hepatic cytolysis	29.59	12.68	35	30707	14014	64453976
Mental status changes postoperative	29.01	12.68	8	30734	158	64467832
Motor neurone disease	28.88	12.68	10	30732	429	64467561
Insomnia	28.87	12.68	31	30711	197805	64270185
Sinusitis	28.65	12.68	17	30725	145911	64322079
Anuria	28.55	12.68	40	30702	18924	64449066
Injection site pain	28.16	12.68	9	30733	111399	64356591
Blood alkaline phosphatase increased	27.95	12.68	74	30668	56205	64411785
Retinal infarction	27.58	12.68	8	30734	191	64467799
Device related infection	27.42	12.68	51	30691	30575	64437415
Intentional product use issue	27.33	12.68	6	30736	95358	64372632
Confusion postoperative	27.30	12.68	8	30734	198	64467792
Endocarditis bacterial	26.79	12.68	13	30729	1330	64466660
Disseminated intravascular coagulation	26.66	12.68	52	30690	32296	64435694
Skin test positive	26.60	12.68	12	30730	1041	64466949
Abscess neck	26.53	12.68	12	30730	1047	64466943
Lung consolidation	26.48	12.68	25	30717	7733	64460257
Septic embolus	26.23	12.68	14	30728	1748	64466242
Hyperaldosteronism	26.20	12.68	9	30733	377	64467613
Sputum increased	25.87	12.68	18	30724	3617	64464373
Stoma closure	25.79	12.68	7	30735	130	64467860
Staphylococcal infection	25.54	12.68	67	30675	50611	64417379
Asthma	25.33	12.68	7	30735	95218	64372772
Corneal oedema	25.08	12.68	15	30727	2328	64465662
Myeloma cast nephropathy	24.89	12.68	7	30735	149	64467841
Thrombocytopenia	24.75	12.68	187	30555	223614	64244376
Procedural hypertension	24.58	12.68	8	30734	283	64467707
Excessive eye blinking	24.54	12.68	12	30730	1248	64466742
Rash morbilliform	24.45	12.68	20	30722	5121	64462869
Face oedema	24.41	12.68	43	30699	24718	64443272
Hypoprothrombinaemia	24.08	12.68	10	30732	709	64467281
Hepatocellular injury	24.03	12.68	61	30681	45174	64422816
Pyroglutamic acidosis	23.85	12.68	10	30732	726	64467264
Oscillopsia	23.75	12.68	7	30735	177	64467813
Bacillus infection	23.72	12.68	10	30732	736	64467254
Endophthalmitis	23.70	12.68	20	30722	5345	64462645
Drug level increased	23.50	12.68	51	30691	34145	64433845
Endocarditis candida	23.43	12.68	6	30736	88	64467902
Disease complication	23.33	12.68	18	30724	4237	64463753
Hyperchlorhydria	23.20	12.68	13	30729	1786	64466204
Puerperal pyrexia	22.99	12.68	5	30737	34	64467956
Cerebral ischaemia	22.96	12.68	26	30716	9936	64458054
Fungaemia	22.94	12.68	17	30725	3768	64464222
Intervertebral discitis	22.66	12.68	17	30725	3840	64464150
Dizziness	22.52	12.68	117	30625	430046	64037944
Neutropenic sepsis	22.41	12.68	40	30702	23232	64444758
Depression	22.28	12.68	33	30709	183258	64284732
Acute respiratory distress syndrome	22.26	12.68	54	30688	38881	64429109
Lymphocyte morphology abnormal	22.22	12.68	10	30732	862	64467128
Lemierre syndrome	22.03	12.68	6	30736	113	64467877
Aortic valve disease	21.89	12.68	12	30730	1581	64466409
Muscle spasms	21.82	12.68	21	30721	141002	64326988
Resuscitation	21.62	12.68	13	30729	2038	64465952
Ischaemic cerebral infarction	21.50	12.68	13	30729	2059	64465931
Lower respiratory tract infection bacterial	21.32	12.68	9	30733	665	64467325
Suicide attempt	21.32	12.68	4	30738	71003	64396987
Brain injury	21.28	12.68	25	30717	9940	64458050
Nutritional condition abnormal	21.24	12.68	10	30732	956	64467034
Pseudomembranous colitis	21.05	12.68	18	30724	4898	64463092
Glossodynia	20.86	12.68	3	30739	64693	64403297
Chest discomfort	20.78	12.68	15	30727	116091	64351899
Blood culture positive	20.68	12.68	22	30720	7846	64460144
Musculoskeletal stiffness	20.68	12.68	17	30725	123189	64344801
Peritoneal dialysis complication	20.63	12.68	13	30729	2215	64465775
Haemophagocytic lymphohistiocytosis	20.58	12.68	33	30709	17576	64450414
Staphylococcal bacteraemia	20.50	12.68	25	30717	10330	64457660
Weight decreased	20.35	12.68	69	30673	285670	64182320
Macroglossia	20.25	12.68	10	30732	1062	64466928
ADAMTS13 activity decreased	20.23	12.68	6	30736	155	64467835
Mast cell degranulation present	20.23	12.68	5	30737	63	64467927
Influenza	20.09	12.68	13	30729	106518	64361472
Blood pressure increased	20.08	12.68	32	30710	172520	64295470
Neutropenia	20.00	12.68	188	30554	239436	64228554
Chest X-ray abnormal	19.94	12.68	20	30722	6661	64461329
Escherichia infection	19.93	12.68	30	30712	15138	64452852
Hepatitis	19.73	12.68	57	30685	45525	64422465
Learning disorder	19.67	12.68	8	30734	538	64467452
Acinetobacter infection	19.60	12.68	13	30729	2416	64465574
Psoriasis	19.58	12.68	5	30737	71698	64396292
Listeriosis	19.52	12.68	12	30730	1958	64466032
Suicidal ideation	19.45	12.68	4	30738	66538	64401452
Haematochezia	19.38	12.68	4	30738	66369	64401621
Chronic obstructive pulmonary disease	19.31	12.68	5	30737	71043	64396947
Premature delivery	19.26	12.68	33	30709	18556	64449434
Stenotrophomonas test positive	19.15	12.68	7	30735	352	64467638
Trichosporon infection	18.90	12.68	9	30733	883	64467107
Cough	18.88	12.68	77	30665	302071	64165919
Wrong technique in product usage process	18.79	12.68	4	30738	64970	64403020
Bronchial disorder	18.73	12.68	12	30730	2103	64465887
Geotrichum infection	18.65	12.68	9	30733	909	64467081
Feeling abnormal	18.33	12.68	22	30720	133580	64334410
Rash macular	18.22	12.68	37	30705	23648	64444342
Folate deficiency	18.09	12.68	13	30729	2750	64465240
Clostridium difficile colitis	18.02	12.68	40	30702	27183	64440807
Hypersensitivity vasculitis	17.94	12.68	19	30723	6742	64461248
Migraine	17.84	12.68	4	30738	62673	64405317
Mycobacterium abscessus infection	17.80	12.68	9	30733	1005	64466985
Metabolic acidosis	17.79	12.68	74	30668	70884	64397106
Infusion related reaction	17.75	12.68	32	30710	164435	64303555
Type IV hypersensitivity reaction	17.73	12.68	14	30728	3408	64464582
Hypopyon	17.68	12.68	9	30733	1020	64466970
Hypoglossal nerve paresis	17.62	12.68	5	30737	110	64467880
Metabolic disorder	17.59	12.68	20	30722	7677	64460313
Antineutrophil cytoplasmic antibody	17.51	12.68	4	30738	35	64467955
Pulmonary valve disease	17.34	12.68	6	30736	257	64467733
Dyspnoea	17.33	12.68	240	30502	718434	63749556
Exfoliative rash	17.29	12.68	14	30728	3532	64464458
Motor dysfunction	17.13	12.68	24	30718	11349	64456641
Serratia infection	17.02	12.68	10	30732	1503	64466487
CD4 lymphocytes increased	16.95	12.68	6	30736	275	64467715
Reticulocytosis	16.90	12.68	7	30735	493	64467497
Dyspnoea exertional	16.86	12.68	7	30735	73723	64394267
Systemic infection	16.85	12.68	15	30727	4306	64463684
Contraindicated product administered	16.74	12.68	16	30726	107813	64360177
Shock	16.72	12.68	48	30694	38192	64429798
Fluid retention	16.58	12.68	4	30738	59602	64408388
HIV associated nephropathy	16.55	12.68	6	30736	295	64467695
Infusion site necrosis	16.52	12.68	4	30738	46	64467944
Contusion	16.46	12.68	18	30724	113947	64354043
Infusion site induration	16.42	12.68	8	30734	825	64467165
Loss of personal independence in daily activities	16.37	12.68	7	30735	72447	64395543
Tonsillitis bacterial	16.28	12.68	5	30737	146	64467844
Toxicity to various agents	16.26	12.68	104	30638	363409	64104581
Red blood cell schistocytes present	16.26	12.68	7	30735	543	64467447
Staphylococcal sepsis	16.22	12.68	25	30717	12874	64455116
Respiratory alkalosis	16.14	12.68	14	30728	3883	64464107
Arthritis	16.11	12.68	10	30732	83804	64384186
Toxic shock syndrome	15.96	12.68	8	30734	878	64467112
Eosinophilic pneumonia acute	15.95	12.68	8	30734	879	64467111
Constipation	15.90	12.68	56	30686	229281	64238709
Dermatitis exfoliative	15.83	12.68	22	30720	10330	64457660
VIIIth nerve injury	15.79	12.68	3	30739	9	64467981
Deafness	15.72	12.68	30	30712	18329	64449661
Aspergillus infection	15.58	12.68	28	30714	16351	64451639
Pseudo-Bartter syndrome	15.54	12.68	4	30738	60	64467930
Arthritis reactive	15.52	12.68	6	30736	353	64467637
Drug eruption	15.45	12.68	45	30697	36091	64431899
Circulatory collapse	15.39	12.68	43	30699	33689	64434301
Cardiac failure congestive	15.39	12.68	24	30718	130556	64337434
Myalgia	15.28	12.68	33	30709	158584	64309406
Haematuria	15.11	12.68	63	30679	60408	64407582
Therapeutic drug monitoring analysis incorrectly performed	15.10	12.68	5	30737	187	64467803
Blood phosphorus decreased	15.08	12.68	16	30726	5689	64462301
Pseudomonas infection	15.04	12.68	29	30713	17854	64450136
Urogenital disorder	15.01	12.68	4	30738	69	64467921
Drug interaction	14.96	12.68	249	30493	361834	64106156
Kussmaul respiration	14.93	12.68	6	30736	391	64467599
Gait disturbance	14.83	12.68	38	30704	172117	64295873
Death	14.75	12.68	153	30589	482552	63985438
Haemolysis	14.74	12.68	22	30720	11017	64456973
Alopecia	14.72	12.68	36	30706	165654	64302336
Antibiotic level below therapeutic	14.70	12.68	4	30738	75	64467915
Status epilepticus	14.53	12.68	32	30710	21631	64446359
Nosocomial infection	14.50	12.68	11	30731	2526	64465464
Spinal subdural haematoma	14.45	12.68	5	30737	214	64467776
Chondrocalcinosis	14.36	12.68	7	30735	723	64467267
Pancytopenia	14.31	12.68	117	30625	143192	64324798
Swelling	14.09	12.68	35	30707	160183	64307807
Inappropriate schedule of product administration	13.97	12.68	14	30728	92272	64375718
Bronchitis	13.78	12.68	19	30723	108724	64359266
Fixed eruption	13.77	12.68	10	30732	2149	64465841
Dialysis	13.70	12.68	27	30715	16893	64451097
COVID-19	13.63	12.68	7	30735	65133	64402857
Clostridium test positive	13.55	12.68	13	30729	4102	64463888
Wound	13.53	12.68	10	30732	76467	64391523
Necrosis	13.45	12.68	18	30724	8153	64459837
Dry mouth	13.39	12.68	6	30736	60412	64407578
Hypocalcaemia	13.30	12.68	47	30695	41706	64426284
Auditory neuropathy spectrum disorder	13.15	12.68	3	30739	26	64467964
Back pain	13.09	12.68	68	30674	250103	64217887
Nephropathy	13.09	12.68	18	30724	8368	64459622
Hypoperfusion	13.03	12.68	10	30732	2336	64465654
Wound dehiscence	12.98	12.68	15	30727	5859	64462131
Hypokalaemia	12.98	12.68	101	30641	121802	64346188
Memory impairment	12.97	12.68	13	30729	85669	64382321
Bacteraemia	12.97	12.68	35	30707	26876	64441114
Osteoarthritis	12.97	12.68	7	30735	63329	64404661
Retinal toxicity	12.92	12.68	8	30734	1322	64466668
Clostridial infection	12.90	12.68	14	30728	5105	64462885
Enterobacter infection	12.79	12.68	12	30730	3684	64464306
Arterial angioplasty	12.77	12.68	3	30739	30	64467960
Immune reconstitution inflammatory syndrome	12.74	12.68	22	30720	12448	64455542
Blood cholesterol increased	12.73	12.68	4	30738	50062	64417928
Pancreatitis haemorrhagic	12.69	12.68	6	30736	579	64467411

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Foetal exposure during pregnancy	55.70	26.62	8	565	11403	72702
Drug ineffective	30.73	26.62	34	539	883	83222
Blister	28.06	26.62	7	566	0	84105

Pharmacologic Action:

Source	Code	Description
ATC	D06AX07	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use
ATC	J01GB03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMINOGLYCOSIDE ANTIBACTERIALS Other aminoglycosides
ATC	S01AA11	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
ATC	S02AA14	SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives
ATC	S03AA06	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives
FDA CS	M0000946	Aminoglycosides
FDA EPC	N0000175477	Aminoglycoside Antibacterial
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D011500	Protein Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Septicemia due to Escherichia coli	indication	9323009
Bacterial septicemia	indication	10001005	DOID:0040085
Infection due to Pseudomonas aeruginosa	indication	11218009
Folliculitis	indication	13600006	DOID:4409
Infection of skin AND/OR subcutaneous tissue	indication	19824006
Pneumonia due to Pseudomonas	indication	41381004
Peritonitis	indication	48661000
Pneumonia due to Escherichia coli	indication	51530003
Bacterial pneumonia	indication	53084003	DOID:874
Blepharoconjunctivitis	indication	68659002	DOID:2456
Infection due to Escherichia coli	indication	71057007
Bacterial infection due to Serratia	indication	71120004
Paronychia	indication	71906005	DOID:13117
Rhinoscleroma	indication	72409005	DOID:11336
Septicemia due to Serratia	indication	82091000
Cholangitis	indication	82403002	DOID:9446
Dacryocystitis	indication	85777005	DOID:9938
Bacterial meningitis	indication	95883001	DOID:9470
Infection of bone	indication	111253001
Furunculosis	indication	112650006
Infectious disease of abdomen	indication	128070006
Bacterial conjunctivitis	indication	128350005	DOID:9700
Bacterial infection of skin	indication	128936008
Infection due to Enterobacteriaceae	indication	128945009
Bacterial infection due to Klebsiella pneumoniae	indication	186435004
Proteus pneumonia	indication	195888009
Sepsis of the newborn	indication	206376005
Neonatal pneumonia	indication	233619008
Neonatal meningitis	indication	276674008
Proteus septicemia	indication	300986008
Meibomianitis	indication	309779001
Infective blepharitis	indication	312219000
Bacterial keratitis	indication	314557000
Infectious disorder of joint	indication	363162000
Sepsis due to Pseudomonas	indication	448813005
Sepsis due to Gram negative bacteria	indication	449082003
Skin and Skin Structure Serratia Infection	indication
Synergy for Escherichia Coli Meningitis	indication
Synergy for Staphylococcal Infections	indication
Pseudomonas Aeruginosa Meningitis	indication
Synergy for Skin and Skin Structure Pseudomonas Aeruginosa Infection	indication
Skin and Skin Structure Pseudomonas Aeruginosa Infection	indication
Synergy for Staphylococcus Aureus Pneumonia	indication
Gram-Negative Aerobic Bacillary Pneumonia	indication
Enterobacter Pneumonia	indication
Synergy for Klebsiella Meningitis	indication
Burn Wound Infections	indication
Complicated UTI with Pseudomonas Aeruginosa	indication
Pseudomonas Aeruginosa Osteomyelitis	indication
Synergy for Proteus Meningitis	indication
Synergy for Group B Streptococcal Septicemia	indication
Citrobacter Pneumonia	indication
Synergy for Staphylococcal Endocarditis	indication
Synergy for Pseudomonas Aeruginosa Joint Infection	indication
Synergy for Pseudomonas Aeruginosa Osteomyelitis	indication
Synergy for Neonatal Meningitis	indication
Skin and Skin Structure Proteus Infection	indication
Synergy for Staphylococcal Joint Infection	indication
Citrobacter Septicemia	indication
Pseudomonas Aeruginosa Joint Infection	indication
Pseudomonas Aeruginosa Biliary Tract Infection	indication
Skin and Skin Structure Citrobacter Infection	indication
Synergy for Pseudomonas Aeruginosa Pneumonia	indication
Synergy for Bacterial Meningitis	indication
Synergy for Staphylococcus Skin and Skin Structure Infection	indication
Complicated Urinary Tract Infections	indication
Synergy for Pseudomonas Aeruginosa Meningitis	indication
Synergy for Staphylococcal Septicemia	indication
Complicated Bacterial Peritonitis	indication
Synergy for Pseudomonas Aeruginosa Septicemia	indication
Synergy for Citrobacter Meningitis	indication
Synergy for Serratia Meningitis	indication
Synergy for Enterobacter Meningitis	indication
Klebsiella Septicemia	indication
Necrotizing enterocolitis in fetus OR newborn	off-label use	2707005
Pyrexia of unknown origin	off-label use	7520000
Ecthyma gangrenosum	off-label use	17732003
Enteric campylobacteriosis	off-label use	18081009
Pseudotuberculosis	off-label use	36753006
Plague	off-label use	58750007	DOID:3482
Infection by Yersinia enterocolitica	off-label use	80960004
Infection by Campylobacter fetus	off-label use	111835002
Prevention of Perioperative Infection	off-label use
Pseudomonas Respiratory Tract Infection in Cystic Fibrosis	off-label use
Synergy for Prevention of Enterococcal Endocarditis	off-label use
Listeria Monocytogenes Septicemia	off-label use
Synergy for Enterococcal Endocarditis	off-label use
Synergy for Listeria Monocytogenes Septicemia	off-label use
Synergy for Enterococcal Infections	off-label use
Synergy for Streptococcal Endocarditis	off-label use
Ocular hypertension	contraindication	4210003	DOID:9282
Hypocalcemia	contraindication	5291005
Herpes simplex keratitis	contraindication	9389005
Herpes simplex dendritic keratitis	contraindication	29943008
Fungal infection of eye	contraindication	31194008
Parkinsonism	contraindication	32798002
Dehydration	contraindication	34095006
Severe myopia	contraindication	34187009
Tuberculosis of eye	contraindication	49107007
Tinnitus	contraindication	60862001
Diabetes mellitus	contraindication	73211009	DOID:9351
Open-angle glaucoma	contraindication	84494001	DOID:1067
Krukenberg spindle	contraindication	85430004
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Eye infection	contraindication	128351009
Bacterial infection of eye	contraindication	128984004
Pregnancy, function	contraindication	289908002
Viral eye infection	contraindication	312132001
Vaccinia keratitis	contraindication	397552005
Vertigo	contraindication	399153001
Denuded skin	contraindication	418242004
Gentamicin Toxicity	contraindication
Infant Botulism	contraindication
Disorder of the 8th Cranial Nerve	contraindication

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Urinary tract infections	Indication
Cats	Respiratory tract infections	Indication
Cats	Skin and soft tissue infections	Indication
Cats	Supportive therapy for secondary bacterial infections associated with panleucopenia	Indication
Cats	Conjunctivitis	Indication
Cattle	Infectious bovine keratoconjunctivitis associated with Moraxella bovis	Indication
Chickens	Prevention of early mortality caused by Escherichia coli	Indication
Chickens	Prevention of early mortality caused by Salmonella typhimurium	Indication
Chickens	Prevention of early mortality caused by Pseudomonas aeruginosa	Indication
Dogs	External eye infections	Indication
Dogs	Acute and chronic otitis externa caused by bacteria	Indication
Dogs	Urinary tract infections	Indication
Dogs	Respiratory tract infections	Indication
Dogs	Skin and soft tissue infections	Indication
Horses	Uterus infections	Indication
Horses	Improving conception in mares with uterine infections	Indication
Swine	Dysentery associated with Brachyspira hyodysenteriae	Indication
Swine	PorcinEscherichia colibacillosis caused by Escherichia coli	Indication
Turkeys	Prevention of early mortality caused by Arizona paracolon infections	Indication
Turkeys	Reduction or elimination of Arizona hinshawii	Indication
Turkeys	Reduction or elimination of Salmonella st paul	Indication
Turkeys	Reduction or elimination of Mycoplasma meleagris	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Gentocin Durafilm	Intervet Inc.	2
Gentocin Solution	Intervet Inc.	1
Gentocin Solution	Intervet Inc.	1
Gentocin Otic Solution	Intervet Inc.	2
Garacin	Intervet Inc.	1
Garasol Solution	Intervet Inc.	1
Gentocin Ophthalmic Ointment	Intervet Inc.	1
Gentocin Ophthalmic Solution	Intervet Inc.	1
Garasol Injection	Intervet Inc.	1
Garacin Piglet Injection	Intervet Inc.	1
Topagen Ointment	Intervet Inc.	2
Gentocin (Garacin) Pig Pump Oral Solution	Intervet Inc.	1
Gentocin Pink Eye Spray	Intervet Inc.	1
Gentocin Topical Spray	Intervet Inc.	2
Garacin Soluble Powder	Intervet Inc.	1
Gentamicin Sulfate Inj. Sol.	Cronus Pharma Specialities India Private Limited	1
Otomax	Intervet Inc.	3
Mometamax Otic Suspension	Intervet Inc.	3
Easotic	Virbac AH Inc.	3
Gentamicin Sulfate Solution 100 mg/ml	Cronus Pharma Specialities India Private Limited	1
Gentamicin Sulfate Solution, Legacy Sterile Solution	Huvepharma EOOD	1
Gentaglyde Solution	Zoetis Inc.	1
Gentamex 100	Bimeda Animal Health Limited	1
GentaMax 100	Elanco US Inc.	1
Genta-Ject, Gentamicin Sulfate Injection	Huvepharma EOOD	1
Gentamicin Sulfate Pig Pump Oral Solution	Huvepharma EOOD	1
VET BETA-GEN	Med-Pharmex Inc.	2
GEN-GARD	Huvepharma EOOD	1
Betagen Topical Spray	Med-Pharmex Inc.	2
GENTORAL	Med-Pharmex Inc.	1
Gentasol	Med-Pharmex Inc.	1
Tri-Otic Ointment	Med-Pharmex Inc.	3
Vetro-Gen Veterinary Ophthalmic Ointment	Dechra Veterinary Products LLC	1
Vetro-Max	Fougera Pharmaceuticals Inc.	3
GBC Ointment	Cronus Pharma Specialities India Private Limited	3
GB Topical Spray	Dechra Veterinary Products LLC	2
Gentamicin Piglet Injection	Sparhawk Laboratories Inc.	1
Gentamicin Sulfate Solution	Sparhawk Laboratories Inc.	1
Gentamicin Sulfate Topical Spray	First Priority Inc.	2
Gentamicin Topical Spray	Sparhawk Laboratories Inc.	2
GentaMed-P for Poultry Injection	Bimeda Animal Health Limited	1
GentaMed	Bimeda Animal Health Limited	1
Mometavet	Med-Pharmex Inc.	3
Gentamicin Sulfate Ophthalmic Solution	Akorn Animal Health Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Dihydrofolate reductase	Enzyme	P00374	DYR_HUMAN		IC50	4.74	CHEMBL
Dihydrofolate reductase	Enzyme		DYR_BOVIN		IC50	4.60	CHEMBL
Transient receptor potential cation channel subfamily A member 1	Ion channel		TRPA1_MOUSE	GATING INHIBITOR	IC50	5.20	IUPHAR

External reference:

ID	Source
4019765	VUID
N0000179542	NUI
D01063	KEGG_DRUG
4018210	VANDF
4019765	VANDF
C3854019	UMLSCUI
CHEBI:17833	CHEBI
CHEMBL3039597	ChEMBL_ID
CHEMBL463809	ChEMBL_ID
CHEMBL3039594	ChEMBL_ID
D005839	MESH_DESCRIPTOR_UI
DB00798	DRUGBANK_ID
2427	IUPHAR_LIGAND_ID
1617	INN_ID
T6Z9V48IKG	UNII
3467	PUBCHEM_CID
1596450	RXNORM
228599	MMSL
4779	MMSL
d00014	MMSL
002778	NDDF
004898	NDDF
2249001	SNOMEDCT_US
387321007	SNOMEDCT_US
57752001	SNOMEDCT_US
1403-66-3	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
PRED-G	HUMAN PRESCRIPTION DRUG LABEL	2	0023-0066	OINTMENT	3 mg	OPHTHALMIC	NDA	17 sections
PRED-G	HUMAN PRESCRIPTION DRUG LABEL	2	0023-0106	SUSPENSION/ DROPS	3 mg	OPHTHALMIC	NDA	18 sections
Gentamicin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9128	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	16 sections
Gentamicin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9129	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	16 sections
Gentamicin sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0078	OINTMENT	1 mg	TOPICAL	ANDA	10 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0503	INJECTION, SOLUTION	80 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0505	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0507	INJECTION, SOLUTION	60 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0509	INJECTION, SOLUTION	80 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0511	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9865	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	12 sections
Gentamicin	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9866	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	13 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1207	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	17 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1207	INJECTION, SOLUTION	40 mg	INTRAMUSCULAR	ANDA	17 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0682	OINTMENT	1 mg	TOPICAL	ANDA	9 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0682	OINTMENT	1 mg	TOPICAL	ANDA	9 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0683	CREAM	1 mg	TOPICAL	ANDA	9 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0683	CREAM	1 mg	TOPICAL	ANDA	9 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	13985-603	OINTMENT	3 mg	OPHTHALMIC	ANDA	18 sections
GENTAMICIN SULFATE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-107	CREAM	1 mg	TOPICAL	ANDA	10 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	17478-283	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	18 sections
Gentak	HUMAN PRESCRIPTION DRUG LABEL	1	17478-284	OINTMENT	3 mg	OPHTHALMIC	ANDA	18 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	17478-826	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	17 sections
Gentak	HUMAN PRESCRIPTION DRUG LABEL	1	17478-827	OINTMENT	3 mg	OPHTHALMIC	ANDA	17 sections
GENTAMICIN SULFATE	HUMAN PRESCRIPTION DRUG LABEL	1	21695-187	SOLUTION	3 mg	OPHTHALMIC	ANDA	15 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	24208-580	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	15 sections
GENTAMICIN SULFATE	HUMAN PRESCRIPTION DRUG LABEL	1	33261-604	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	17 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	45802-046	OINTMENT	1 mg	TOPICAL	ANDA	11 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	45802-056	CREAM	1 mg	TOPICAL	ANDA	11 sections
Gentamicin Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	45865-672	SOLUTION/ DROPS	3 mg	OPHTHALMIC	ANDA	15 sections