Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4739	1404-88-2

Description:

Molecule	Description
Synonyms: tyrothricin tirotrisin tyrothricine tyrotricin	A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

tyrothricin
tirotrisin
tyrothricine
tyrotricin

A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Seronegative arthritis	256.37	53.00	98	13414	18136	90596799
Joint dislocation	246	53.00	124	13388	44458	90570477
Prescribed underdose	210.51	53.00	134	13378	74885	90540050
Wound infection	190.11	53.00	144	13368	106258	90508677
Walking aid user	187.79	53.00	96	13416	35410	90579525
Joint stiffness	186.28	53.00	126	13386	77916	90537019
Retinitis	180.56	53.00	96	13416	38362	90576573
Lupus vulgaris	177.08	53.00	100	13412	44959	90569976
Lupus-like syndrome	164.34	53.00	98	13414	48748	90566187
Laryngitis	163.44	53.00	99	13413	50654	90564281
Visual impairment	154.57	53.00	140	13372	132225	90482710
Upper respiratory tract infection	152.35	53.00	137	13375	128181	90486754
Osteoporosis	140.86	53.00	116	13396	96415	90518520
Anti-cyclic citrullinated peptide antibody	139.29	53.00	72	13440	27149	90587786
Drug ineffective	127.74	53.00	26	13486	1384272	89230663
Hypercholesterolaemia	122.24	53.00	109	13403	100783	90514152
Spinal fusion surgery	120.59	53.00	51	13461	12232	90602703
Spondylitis	119.97	53.00	53	13459	14125	90600810
Type 2 diabetes mellitus	117.55	53.00	148	13364	203096	90411839
Joint range of motion decreased	116.06	53.00	121	13391	135522	90479413
Adjustment disorder with depressed mood	115.18	53.00	83	13429	56670	90558265
Hepatic cirrhosis	113.74	53.00	86	13426	63167	90551768
Exostosis	113.11	53.00	80	13432	53054	90561881
Hip arthroplasty	112.02	53.00	92	13420	76116	90538819
Dislocation of vertebra	111.64	53.00	81	13431	55887	90559048
Foot deformity	111.48	53.00	83	13429	59568	90555367
Liver function test increased	111.46	53.00	96	13416	84759	90530176
Bone erosion	110.95	53.00	79	13433	52942	90561993
Prescribed overdose	105.62	53.00	99	13413	97526	90517409
Red blood cell sedimentation rate increased	103.55	53.00	91	13421	82504	90532431
Disability	97.65	53.00	66	13446	40679	90574256
Deep vein thrombosis postoperative	96.84	53.00	82	13430	70727	90544208
Sciatica	96.83	53.00	96	13416	101286	90513649
Lower limb fracture	93.47	53.00	87	13425	84926	90530009
Wheezing	92.19	53.00	143	13369	237937	90376998
Swollen joint count increased	91.17	53.00	97	13415	111109	90503826
Pulmonary fibrosis	90.32	53.00	95	13417	107408	90507527
Ear infection	89.71	53.00	78	13434	69697	90545238
Road traffic accident	88.45	53.00	94	13418	107532	90507403
Autoimmune disorder	87.20	53.00	80	13432	76664	90538271
Osteoarthritis	82.02	53.00	122	13390	195608	90419327
Grip strength decreased	81.69	53.00	84	13428	92492	90522443
Irritable bowel syndrome	78.05	53.00	123	13389	207325	90407610
Oedema	74.29	53.00	118	13394	200177	90414758
Delirium	71.69	53.00	83	13429	104276	90510659
Knee arthroplasty	70.72	53.00	74	13438	83108	90531827
Wound	66.16	53.00	142	13370	302838	90312097
Amnesia	65.81	53.00	81	13431	108424	90506511
Drug-induced liver injury	65.69	53.00	74	13438	90244	90524691
Psoriasis	64.61	53.00	94	13418	147660	90467275
Rheumatic fever	63.48	53.00	95	13417	153026	90461909
Tachycardia	61.37	53.00	95	13417	157578	90457357
Liver injury	61.19	53.00	99	13413	170468	90444467
Injury	59.50	53.00	106	13406	197243	90417692
Fall	59.48	53.00	3	13509	481807	90133128
Gait inability	59.47	53.00	90	13422	146366	90468569
Rheumatoid factor positive	58.03	53.00	97	13415	171553	90443382
Urticaria	57.59	53.00	137	13375	312597	90302338
Breast cancer stage III	56.04	53.00	66	13446	84381	90530554
Muscle injury	53.39	53.00	95	13417	176559	90438376

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Seronegative arthritis	45.54	31.76	16	2924	13161	110573198
Spinal fusion surgery	38.99	31.76	13	2927	9143	110577216
Prescribed underdose	33.19	31.76	21	2919	65153	110521206
Adjustment disorder with depressed mood	32.47	31.76	18	2922	43865	110542494

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D06AX08	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use
ATC	R02AB02	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antibiotics
ATC	S01AA05	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D000900	Anti-Bacterial Agents

Related Drugs by ATC class:

D06AX Other antibiotics for topical use 12 drugs

amikacin bacitracin chloramphenicol fusidic acid gentamicin mupirocin neomycin ozenoxacin retapamulin rifamycin rifaximin virginiamycin

R02AB Antibiotics 4 drugs

bacitracin fusafungine gramicidin neomycin

S01AA Antibiotics 27 drugs

amikacin ampicillin azidamfenicol azithromycin bacitracin benzylpenicillin cefmenoxime cefuroxime chloramphenicol chlortetracycline dibekacin dihydrostreptomycin show all 27 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D06262	KEGG_DRUG
N0000007931	NUI
CHEMBL577736	ChEMBL_ID
DB13503	DRUGBANK_ID
877376V2XW	UNII
10968	RXNORM
002800	NDDF
36661005	SNOMEDCT_US
404827006	SNOMEDCT_US
C0041499	UMLSCUI
D014449	MESH_DESCRIPTOR_UI
1344	INN_ID
452550	PUBCHEM_CID

Pharmaceutical products:

None

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tyrothricin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: