tyrothricin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4739 1404-88-2

Description:

MoleculeDescription

Synonyms:

  • tyrothricin
  • tirotrisin
  • tyrothricine
  • tyrotricin
A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seronegative arthritis 256.37 53.00 98 13414 18136 90596799
Joint dislocation 246 53.00 124 13388 44458 90570477
Prescribed underdose 210.51 53.00 134 13378 74885 90540050
Wound infection 190.11 53.00 144 13368 106258 90508677
Walking aid user 187.79 53.00 96 13416 35410 90579525
Joint stiffness 186.28 53.00 126 13386 77916 90537019
Retinitis 180.56 53.00 96 13416 38362 90576573
Lupus vulgaris 177.08 53.00 100 13412 44959 90569976
Lupus-like syndrome 164.34 53.00 98 13414 48748 90566187
Laryngitis 163.44 53.00 99 13413 50654 90564281
Visual impairment 154.57 53.00 140 13372 132225 90482710
Upper respiratory tract infection 152.35 53.00 137 13375 128181 90486754
Osteoporosis 140.86 53.00 116 13396 96415 90518520
Anti-cyclic citrullinated peptide antibody 139.29 53.00 72 13440 27149 90587786
Drug ineffective 127.74 53.00 26 13486 1384272 89230663
Hypercholesterolaemia 122.24 53.00 109 13403 100783 90514152
Spinal fusion surgery 120.59 53.00 51 13461 12232 90602703
Spondylitis 119.97 53.00 53 13459 14125 90600810
Type 2 diabetes mellitus 117.55 53.00 148 13364 203096 90411839
Joint range of motion decreased 116.06 53.00 121 13391 135522 90479413
Adjustment disorder with depressed mood 115.18 53.00 83 13429 56670 90558265
Hepatic cirrhosis 113.74 53.00 86 13426 63167 90551768
Exostosis 113.11 53.00 80 13432 53054 90561881
Hip arthroplasty 112.02 53.00 92 13420 76116 90538819
Dislocation of vertebra 111.64 53.00 81 13431 55887 90559048
Foot deformity 111.48 53.00 83 13429 59568 90555367
Liver function test increased 111.46 53.00 96 13416 84759 90530176
Bone erosion 110.95 53.00 79 13433 52942 90561993
Prescribed overdose 105.62 53.00 99 13413 97526 90517409
Red blood cell sedimentation rate increased 103.55 53.00 91 13421 82504 90532431
Disability 97.65 53.00 66 13446 40679 90574256
Deep vein thrombosis postoperative 96.84 53.00 82 13430 70727 90544208
Sciatica 96.83 53.00 96 13416 101286 90513649
Lower limb fracture 93.47 53.00 87 13425 84926 90530009
Wheezing 92.19 53.00 143 13369 237937 90376998
Swollen joint count increased 91.17 53.00 97 13415 111109 90503826
Pulmonary fibrosis 90.32 53.00 95 13417 107408 90507527
Ear infection 89.71 53.00 78 13434 69697 90545238
Road traffic accident 88.45 53.00 94 13418 107532 90507403
Autoimmune disorder 87.20 53.00 80 13432 76664 90538271
Osteoarthritis 82.02 53.00 122 13390 195608 90419327
Grip strength decreased 81.69 53.00 84 13428 92492 90522443
Irritable bowel syndrome 78.05 53.00 123 13389 207325 90407610
Oedema 74.29 53.00 118 13394 200177 90414758
Delirium 71.69 53.00 83 13429 104276 90510659
Knee arthroplasty 70.72 53.00 74 13438 83108 90531827
Wound 66.16 53.00 142 13370 302838 90312097
Amnesia 65.81 53.00 81 13431 108424 90506511
Drug-induced liver injury 65.69 53.00 74 13438 90244 90524691
Psoriasis 64.61 53.00 94 13418 147660 90467275
Rheumatic fever 63.48 53.00 95 13417 153026 90461909
Tachycardia 61.37 53.00 95 13417 157578 90457357
Liver injury 61.19 53.00 99 13413 170468 90444467
Injury 59.50 53.00 106 13406 197243 90417692
Fall 59.48 53.00 3 13509 481807 90133128
Gait inability 59.47 53.00 90 13422 146366 90468569
Rheumatoid factor positive 58.03 53.00 97 13415 171553 90443382
Urticaria 57.59 53.00 137 13375 312597 90302338
Breast cancer stage III 56.04 53.00 66 13446 84381 90530554
Muscle injury 53.39 53.00 95 13417 176559 90438376

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seronegative arthritis 45.54 31.76 16 2924 13161 110573198
Spinal fusion surgery 38.99 31.76 13 2927 9143 110577216
Prescribed underdose 33.19 31.76 21 2919 65153 110521206
Adjustment disorder with depressed mood 32.47 31.76 18 2922 43865 110542494

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D06AX08 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
ATC R02AB02 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antibiotics
ATC S01AA05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D000900 Anti-Bacterial Agents

Related Drugs by ATC class:

D06AX Other antibiotics for topical use 12 drugs
amikacinbacitracinchloramphenicolfusidic acidgentamicinmupirocinneomycinozenoxacinretapamulinrifamycinrifaximinvirginiamycin
R02AB Antibiotics 4 drugs
bacitracinfusafunginegramicidinneomycin
S01AA Antibiotics 27 drugs
amikacinampicillinazidamfenicolazithromycinbacitracinbenzylpenicillincefmenoximecefuroximechloramphenicolchlortetracyclinedibekacindihydrostreptomycin show all 27 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D06262 KEGG_DRUG
N0000007931 NUI
CHEMBL577736 ChEMBL_ID
DB13503 DRUGBANK_ID
877376V2XW UNII
10968 RXNORM
002800 NDDF
36661005 SNOMEDCT_US
404827006 SNOMEDCT_US
C0041499 UMLSCUI
D014449 MESH_DESCRIPTOR_UI
1344 INN_ID
452550 PUBCHEM_CID

Pharmaceutical products:

None