nitrofurazone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| NO2 - derivatives | 1950 | 59-87-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 4, 1945 | FDA | SHIRE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | B05CA03 | BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Antiinfectives |
| ATC | D08AF01 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Nitrofuran derivatives |
| ATC | D09AA03 | DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives |
| ATC | P01CC02 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS Nitrofuran derivatives |
| ATC | S01AX04 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Other antiinfectives |
| ATC | S02AA02 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Klebsiella cystitis | indication | 60867007 | |
| Escherichia coli urinary tract infection | indication | 301011002 | |
| Staphylococcus Saprophyticus Urinary Tract Infection | indication | ||
| Enterococcus Urinary Tract Infection | indication | ||
| Staphylococcus Aureus Urinary Tract Infection | indication | ||
| Enterobacter Cystitis | indication | ||
| Prevention of Bacterial Urinary Tract Infection | off-label use | ||
| Anuria | contraindication | 2472002 | DOID:2983 |
| Acute hepatitis | contraindication | 37871000 | |
| Vitamin B deficiency | contraindication | 47903000 | |
| Fibrosis of lung | contraindication | 51615001 | DOID:3770 |
| Obstructive hyperbilirubinemia | contraindication | 59848001 | |
| Interstitial pneumonia | contraindication | 64667001 | |
| Optic neuritis | contraindication | 66760008 | DOID:1210 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Chronic hepatitis | contraindication | 76783007 | DOID:2237 |
| Oliguria | contraindication | 83128009 | |
| Cholestatic hepatitis | contraindication | 95556007 | |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Cobalamin deficiency | contraindication | 190634004 | |
| Impaired renal function disorder | contraindication | 197663003 | |
| Drug-induced hepatitis | contraindication | 235876009 | |
| Peripheral nerve disease | contraindication | 302226006 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Surface bacterial infections of wounds | Indication |
| Cats | Surface bacterial infections of burns | Indication |
| Cats | Surface bacterial infections of skin ulcers and abscesses | Indication |
| Dogs | Surface bacterial infections of wounds | Indication |
| Dogs | Surface bacterial infections of burns | Indication |
| Dogs | Surface bacterial infections of skin ulcers and abscesses | Indication |
| Horses | Surface bacterial infections of wounds | Indication |
| Horses | Surface bacterial infections of burns | Indication |
| Horses | Surface bacterial infections of skin ulcers and abscesses | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| NFZ Puffer | Neogen Corp. | 1 |
| Fura Ointment | Farnam Companies Inc. | 1 |
| Fura-Septin Soluble Dressing | Bimeda Animal Health Limited | 1 |
| Nitrofurazone Dressing | Cronus Pharma Specialities India Private Limited | 1 |
| Nitrofurazone Soluble Powder | Cronus Pharma Specialities India Private Limited | 1 |
| Nitrofurazone Ointment | Bimeda Animal Health Limited | 1 |
| Nitrofurazone Anesthetic Dress. | Med-Pharmex Inc. | 2 |
| Fura-Zone | Squire Laboratories Inc. | 1 |
| Nitrofurazone Ointment | Sparhawk Laboratories Inc. | 1 |
| NFZ Wound Dressing | Neogen Corp. | 1 |
| Nitrofurazone Soluble Dressing | Med-Pharmex Inc. | 1 |
| Nitrofurazone Soluble Dressing | First Priority Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.85 | acidic |
| pKa2 | 12.47 | acidic |
| pKa3 | 0.0 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucose-6-phosphate 1-dehydrogenase | Enzyme | WOMBAT-PK | |||||||
| Sterile alpha and TIR motif-containing protein 1 | Unclassified | IC50 | 4.05 | CHEMBL | |||||
| Snake venom metalloproteinase Bap1 | Enzyme | IC50 | 4.06 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018879 | VUID |
| N0000147174 | NUI |
| D00862 | KEGG_DRUG |
| 4018879 | VANDF |
| C0028157 | UMLSCUI |
| CHEBI:44368 | CHEBI |
| NFZ | PDB_CHEM_ID |
| CHEMBL869 | ChEMBL_ID |
| DB00336 | DRUGBANK_ID |
| D009583 | MESH_DESCRIPTOR_UI |
| 5447130 | PUBCHEM_CID |
| 4160 | INN_ID |
| 12366 | IUPHAR_LIGAND_ID |
| X8XI70B5Z6 | UNII |
| 227727 | RXNORM |
| 2323 | MMSL |
| 402 | MMSL |
| 5182 | MMSL |
| 002857 | NDDF |
| 332799007 | SNOMEDCT_US |
| 87097009 | SNOMEDCT_US |
Pharmaceutical products:
None