nitrofurazone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
NO2 - derivatives 1950 59-87-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitrofurazone
  • aldomycin
  • babrocid
  • furacilin
  • furacine
  • furacin
  • furacycline
  • furaldon
  • furaziline
  • nifuzon
  • nitrofural
  • nitrofuraldehyde semicarbazone
  • nitrofuran
  • nitrozone
A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.
  • Molecular weight: 198.14
  • Formula: C6H6N4O4
  • CLOGP: 0.20
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 126.44
  • ALOGS: -2.87
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 4, 1945 FDA SHIRE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05CA03 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Antiinfectives
ATC D08AF01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Nitrofuran derivatives
ATC D09AA03 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC P01CC02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS
Nitrofuran derivatives
ATC S01AX04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Other antiinfectives
ATC S02AA02 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
CHEBI has role CHEBI:36047 antibacterial drug
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Klebsiella cystitis indication 60867007
Escherichia coli urinary tract infection indication 301011002
Staphylococcus Saprophyticus Urinary Tract Infection indication
Enterococcus Urinary Tract Infection indication
Staphylococcus Aureus Urinary Tract Infection indication
Enterobacter Cystitis indication
Prevention of Bacterial Urinary Tract Infection off-label use
Anuria contraindication 2472002 DOID:2983
Acute hepatitis contraindication 37871000
Vitamin B deficiency contraindication 47903000
Fibrosis of lung contraindication 51615001 DOID:3770
Obstructive hyperbilirubinemia contraindication 59848001
Interstitial pneumonia contraindication 64667001
Optic neuritis contraindication 66760008 DOID:1210
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic hepatitis contraindication 76783007 DOID:2237
Oliguria contraindication 83128009
Cholestatic hepatitis contraindication 95556007
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Cobalamin deficiency contraindication 190634004
Impaired renal function disorder contraindication 197663003
Drug-induced hepatitis contraindication 235876009
Peripheral nerve disease contraindication 302226006
Pseudomembranous enterocolitis contraindication 397683000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.85 acidic
pKa2 12.47 acidic
pKa3 0.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucose-6-phosphate 1-dehydrogenase Enzyme WOMBAT-PK
Snake venom metalloproteinase Bap1 Unclassified IC50 4.06 CHEMBL

External reference:

IDSource
4018879 VUID
N0000147174 NUI
C0028157 UMLSCUI
D00862 KEGG_DRUG
332799007 SNOMEDCT_US
4018879 VANDF
2323 MMSL
7455 RXNORM
87097009 SNOMEDCT_US
5182 MMSL
002857 NDDF
5447130 PUBCHEM_CID
CHEBI:44368 CHEBI
CHEMBL869 ChEMBL_ID
DB00336 DRUGBANK_ID
NFZ PDB_CHEM_ID
X8XI70B5Z6 UNII
4160 INN_ID
D009583 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None