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hexetidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| histamine-H2-receptor antagonists, cimetidine derivatives | 3277 | 141-94-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT1,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAP3K7,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,TEK,TGFBR1,ZAP70 | 31 | |||
| kinase-selectivity-class | AXL,CAMK2D,CDK4,EIF2AK3,EPHB4,GAK,INSR,LRRK2,NUAK1,PDK4,PLK1,PTK2,TEK | 13 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Toxic epidermal necrolysis | 56.13 | 48.95 | 13 | 172 | 32515 | 90595747 |
| Bezoar | 50.32 | 48.95 | 8 | 177 | 2726 | 90625536 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A01AB12 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment |
| ATC | G01AX16 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Other antiinfectives and antiseptics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000891 | Anti-Infective Agents, Local |
| MeSH PA | D000935 | Antifungal Agents |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
Related Drugs by ATC class:
A01AB Antiinfectives and antiseptics for local oral treatment 22 drugs
G01AX Other antiinfectives and antiseptics 10 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.52 | Basic |
| pKa2 | 6.52 | Basic |
| pKa3 | 5.17 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167195 | NUI |
| D07068 | KEGG_DRUG |
| C0019468 | UMLSCUI |
| CHEBI:748576 | CHEBI |
| CHEMBL144673 | ChEMBL_ID |
| DB08958 | DRUGBANK_ID |
| D006590 | MESH_DESCRIPTOR_UI |
| 3607 | PUBCHEM_CID |
| 522 | INN_ID |
| 852A84Y8LS | UNII |
| 5301 | RXNORM |
| 18447 | MMSL |
| 003906 | NDDF |
| 2497003 | SNOMEDCT_US |
| 387132001 | SNOMEDCT_US |
Pharmaceutical products:
None