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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
sisomicin ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
aminoglycosides, antibiotics obtained from various Micromonospora
2447
32385-11-8
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
sisomicin
rickamicin
siseptin
sisomicin sulfate
Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).
Molecular weight: 447.53
Formula: C19H37N5O7
CLOGP: -2.69
LIPINSKI: 2
HAC: 12
HDO: 8
TPSA: 213.72
ALOGS: -1.46
ROTB: 6
Drug dosage:
Dose
Unit
Route
0.24
g
P
ADMET properties:
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Property
Value
Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)
6.70 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
t_half (Half-life)
2.40 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
1 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.19 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.15 %
Lombardo F, Berellini G, Obach RS
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Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1977
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
J01GB08
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
AMINOGLYCOSIDE ANTIBACTERIALS
Other aminoglycosides
MeSH PA
D000900
Anti-Bacterial Agents
MeSH PA
D000890
Anti-Infective Agents
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D011500
Protein Synthesis Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.19
Basic
pKa2
8.58
Basic
pKa3
8.02
Basic
pKa4
7.41
Basic
pKa5
5.55
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
30S ribosomal protein S12
Cytosolic other
RS12_ECOLI
WOMBAT-PK
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External reference:
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ID
Source
SIS
PDB_CHEM_ID
002782
NDDF
002783
NDDF
10858
IUPHAR_LIGAND_ID
3027
INN_ID
36119
PUBCHEM_CID
53179-09-2
SECONDARY_CAS_RN
702751001
SNOMEDCT_US
96031003
SNOMEDCT_US
9806
RXNORM
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Pharmaceutical products:
None
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sisomicin