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sisomicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| aminoglycosides, antibiotics obtained from various Micromonospora | 2447 | 32385-11-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.24 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.70 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 0.19 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.15 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.40 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,BRAF,CAMK2D,CDK4,CDK5,DYRK1B,EIF2AK3,GRK2,ITK,MAP2K6,MAPK10,MAPK7,NTRK1,NTRK2,PDK2,PDK4,PRKDC,TEK,TGFBR1,ZAP70 | 20 | |||
| kinase-selectivity-class | CHUK,EIF2AK3,IRAK4,MAP2K6,PDK1 | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1977 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01GB08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMINOGLYCOSIDE ANTIBACTERIALS Other aminoglycosides |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
Related Drugs by ATC class:
J01GB Other aminoglycosides 12 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.19 | Basic |
| pKa2 | 8.58 | Basic |
| pKa3 | 8.02 | Basic |
| pKa4 | 7.41 | Basic |
| pKa5 | 5.55 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 30S ribosomal protein S12 | Cytosolic other | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| N0000007607 | NUI |
| D02181 | KEGG_DRUG |
| C0037209 | UMLSCUI |
| CHEBI:9169 | CHEBI |
| SIS | PDB_CHEM_ID |
| CHEMBL221886 | ChEMBL_ID |
| D012853 | MESH_DESCRIPTOR_UI |
| DB12604 | DRUGBANK_ID |
| 10858 | IUPHAR_LIGAND_ID |
| 3027 | INN_ID |
| 53179-09-2 | SECONDARY_CAS_RN |
| X55XSL74YQ | UNII |
| 36119 | PUBCHEM_CID |
| 9806 | RXNORM |
| 002782 | NDDF |
| 002783 | NDDF |
| 702751001 | SNOMEDCT_US |
| 96031003 | SNOMEDCT_US |
| CHEMBL3989471 | ChEMBL_ID |
Pharmaceutical products:
None