boric acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3035 10043-35-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • boric acid
  • boracic acid
  • trihydroxyborane
  • orthoboric acid
  • boron oxide hydroxide
A weakly acidic hydrate of boric oxide with mild antiseptic, antifungal, and antiviral properties. The exact mechanism of action of boric acid is unknown; generally cytotoxic to all cells. It is used in the treatment of yeast infections and cold sores
  • Molecular weight: 61.83
  • Formula: BH3O3
  • CLOGP:
  • LIPINSKI: None
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 160.00 63.97 32 875 4730 53343429
Pulmonary toxicity 144.32 63.97 30 877 5361 53342798
Neoplasm malignant 106.51 63.97 32 875 25569 53322590
C-reactive protein abnormal 106.18 63.97 32 875 25838 53322321
Hepatotoxicity 103.82 63.97 32 875 27848 53320311
Joint injury 102.27 63.97 30 877 22070 53326089
Therapy non-responder 86.05 63.97 32 875 49088 53299071
Joint stiffness 80.82 63.97 27 880 30256 53317903
Musculoskeletal pain 72.85 63.97 32 875 75168 53272991

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC S02AA03 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
MeSH PA D007306 Insecticides
MeSH PA D010575 Pesticides
CHEBI has role CHEBI:74783 astringents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.99 acidic
pKa2 8.8 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
R57ZHV85D4 UNII
4018204 VUID
N0000146538 NUI
D01089 KEGG_DRUG
4018204 VANDF
C0006020 UMLSCUI
CHEBI:33118 CHEBI
BO3 PDB_CHEM_ID
CHEMBL42403 ChEMBL_ID
7628 PUBCHEM_CID
DB11326 DRUGBANK_ID
C032688 MESH_SUPPLEMENTAL_RECORD_UI
1700 RXNORM
4294 MMSL
4907 MMSL
003185 NDDF
21611007 SNOMEDCT_US
346349006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Gynetox HUMAN OTC DRUG LABEL 21 57520-0103 LIQUID 12 [hp_X] ORAL unapproved homeopathic 9 sections
See Clean-One Eye Drops HUMAN OTC DRUG LABEL 1 58354-105 LIQUID 21.64 mg OPHTHALMIC unapproved drug other 8 sections
Sha-lem HUMAN OTC DRUG LABEL 5 59862-100 OINTMENT 0.95 g TOPICAL unapproved drug other 10 sections
GYNOX-SOFT HUMAN OTC DRUG LABEL 1 66854-003 EMULSION 7 mg TOPICAL unapproved drug other 8 sections
ICEKING Skin Expert Anti-onychomycosis Gel HUMAN OTC DRUG LABEL 2 72501-072 GEL 0.20 g CUTANEOUS Export only 7 sections