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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
netilmicin ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
aminoglycosides, antibiotics obtained from various Micromonospora
1903
56391-56-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
netilmicin sulfate
netilmicin
netromycin
Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.
Molecular weight: 475.59
Formula: C21H41N5O7
CLOGP: -2.40
LIPINSKI: 2
HAC: 12
HDO: 8
TPSA: 199.73
ALOGS: -1.71
ROTB: 8
Status: OFM
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
0.35
g
O
0.35
g
P
ADMET properties:
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Property
Value
Reference
EoM (Fraction excreted unchanged in urine)
85 %
Benet LZ, Broccatelli F, Oprea TI
t_half (Half-life)
3.20 hours
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)
12.62 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
fu (Fraction unbound in plasma)
1 %
Lombardo F, Berellini G, Obach RS
CL (Clearance)
0.55 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.07 L/kg
Lombardo F, Berellini G, Obach RS
BA (Bioavailability)
0 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Showing 1 to 8 of 8 entries
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Approvals:
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Date
Agency
Company
Orphan
Feb. 28, 1983
FDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
J01GB07
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
AMINOGLYCOSIDE ANTIBACTERIALS
Other aminoglycosides
ATC
S01AA23
SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
FDA CS
M0000946
Aminoglycosides
FDA EPC
N0000175477
Aminoglycoside Antibacterial
MeSH PA
D000900
Anti-Bacterial Agents
MeSH PA
D000890
Anti-Infective Agents
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D011500
Protein Synthesis Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hypocalcemia
contraindication
5291005
Parkinsonism
contraindication
32798002
Dehydration
contraindication
34095006
Tinnitus
contraindication
60862001
Kidney disease
contraindication
90708001
DOID:557
Myasthenia gravis
contraindication
91637004
DOID:437
Pregnancy, function
contraindication
289908002
Vertigo
contraindication
399153001
Infant Botulism
contraindication
Disorder of the 8th Cranial Nerve
contraindication
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
12.7
acidic
pKa2
9.19
Basic
pKa3
8.58
Basic
pKa4
7.86
Basic
pKa5
7.21
Basic
pKa6
6.47
Basic
Showing 1 to 6 of 6 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
002785
NDDF
002786
NDDF
10751006
SNOMEDCT_US
12159
IUPHAR_LIGAND_ID
19405002
SNOMEDCT_US
203193
RXNORM
2265
MMSL
387110005
SNOMEDCT_US
4018801
VUID
4018801
VANDF
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Pharmaceutical products:
None
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netilmicin