Stem definition | Drug id | CAS RN |
---|---|---|
4246 | 1405-20-5 |
Molecule | Description |
---|---|
Synonyms:
|
A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.
|
Dose | Unit | Route |
---|---|---|
3 | MU | O |
0.15 | g | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
March 26, 1957 | FDA | MONARCH PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 349.00 | 16.44 | 227 | 3879 | 274978 | 56012983 |
Macular degeneration | 226.74 | 16.44 | 75 | 4031 | 18833 | 56269128 |
Respiratory failure | 38.94 | 16.44 | 41 | 4065 | 95021 | 56192940 |
Drug ineffective | 33.88 | 16.44 | 144 | 3962 | 918845 | 55369116 |
Cytomegalovirus test positive | 32.97 | 16.44 | 11 | 4095 | 2815 | 56285146 |
Septic arthritis staphylococcal | 30.96 | 16.44 | 7 | 4099 | 419 | 56287542 |
Sepsis | 26.35 | 16.44 | 41 | 4065 | 139799 | 56148162 |
Lymphatic disorder | 26.31 | 16.44 | 6 | 4100 | 373 | 56287588 |
Engraft failure | 21.35 | 16.44 | 5 | 4101 | 350 | 56287611 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 39.82 | 18.27 | 46 | 3719 | 72553 | 31621026 |
Respiratory paralysis | 33.77 | 18.27 | 6 | 3759 | 61 | 31693518 |
Mucosal disorder | 30.25 | 18.27 | 10 | 3755 | 1524 | 31692055 |
Disseminated intravascular coagulation | 28.88 | 18.27 | 22 | 3743 | 20515 | 31673064 |
Chronic graft versus host disease | 23.07 | 18.27 | 11 | 3754 | 4381 | 31689198 |
Pathogen resistance | 20.97 | 18.27 | 13 | 3752 | 8688 | 31684891 |
Hepatic function abnormal | 20.71 | 18.27 | 25 | 3740 | 41197 | 31652382 |
Drug resistance | 20.30 | 18.27 | 19 | 3746 | 23434 | 31670145 |
Trichosporon infection | 19.79 | 18.27 | 6 | 3759 | 691 | 31692888 |
Bacterial translocation | 19.36 | 18.27 | 5 | 3760 | 320 | 31693259 |
Acute graft versus host disease in skin | 19.16 | 18.27 | 10 | 3755 | 4822 | 31688757 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 184.65 | 14.93 | 170 | 6486 | 262289 | 70659499 |
Respiratory failure | 42.81 | 14.93 | 65 | 6591 | 168670 | 70753118 |
Drug resistance | 39.53 | 14.93 | 31 | 6625 | 38159 | 70883629 |
Cytomegalovirus test positive | 39.46 | 14.93 | 16 | 6640 | 5492 | 70916296 |
Respiratory paralysis | 35.18 | 14.93 | 6 | 6650 | 61 | 70921727 |
Sepsis | 33.46 | 14.93 | 72 | 6584 | 244473 | 70677315 |
Engraftment syndrome | 30.09 | 14.93 | 9 | 6647 | 1255 | 70920533 |
Disseminated intravascular coagulation | 29.95 | 14.93 | 25 | 6631 | 33573 | 70888215 |
Pathogen resistance | 28.69 | 14.93 | 17 | 6639 | 13262 | 70908526 |
Hepatic function abnormal | 26.03 | 14.93 | 32 | 6624 | 67964 | 70853824 |
Lymphatic disorder | 25.54 | 14.93 | 6 | 6650 | 329 | 70921459 |
Septic arthritis staphylococcal | 25.25 | 14.93 | 7 | 6649 | 745 | 70921043 |
Multiple organ dysfunction syndrome | 24.98 | 14.93 | 40 | 6616 | 108475 | 70813313 |
Febrile neutropenia | 23.30 | 14.93 | 56 | 6600 | 204262 | 70717526 |
Renal injury | 23.29 | 14.93 | 16 | 6640 | 16078 | 70905710 |
Chronic graft versus host disease | 21.01 | 14.93 | 11 | 6645 | 6759 | 70915029 |
Slow response to stimuli | 19.50 | 14.93 | 7 | 6649 | 1726 | 70920062 |
Trichosporon infection | 19.28 | 14.93 | 6 | 6650 | 955 | 70920833 |
Mucosal disorder | 18.57 | 14.93 | 8 | 6648 | 3190 | 70918598 |
Platelet count decreased | 18.36 | 14.93 | 47 | 6609 | 178175 | 70743613 |
Bacterial translocation | 18.05 | 14.93 | 5 | 6651 | 531 | 70921257 |
Drug interaction | 17.43 | 14.93 | 7 | 6649 | 381434 | 70540354 |
Tachypnoea | 17.06 | 14.93 | 17 | 6639 | 28621 | 70893167 |
Mental status changes | 16.96 | 14.93 | 25 | 6631 | 63076 | 70858712 |
Unevaluable event | 16.01 | 14.93 | 22 | 6634 | 52041 | 70869747 |
Pyrexia | 15.74 | 14.93 | 104 | 6552 | 606848 | 70314940 |
Skin hyperpigmentation | 15.57 | 14.93 | 9 | 6647 | 6706 | 70915082 |
Blood chloride increased | 15.23 | 14.93 | 8 | 6648 | 4945 | 70916843 |
Anaphylactic reaction | 15.05 | 14.93 | 26 | 6630 | 74948 | 70846840 |
Corneal abrasion | 14.94 | 14.93 | 5 | 6651 | 1001 | 70920787 |
None
Source | Code | Description |
---|---|---|
ATC | A07AA05 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Antibiotics |
ATC | J01XB02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Polymyxins |
ATC | S01AA18 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
ATC | S02AA11 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
ATC | S03AA03 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives |
FDA CS | M0017217 | Polymyxins |
FDA EPC | N0000175499 | Polymyxin-class Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Otitis externa | indication | 3135009 | |
Keratitis | indication | 5888003 | DOID:4677 |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Urinary tract infectious disease | indication | 68566005 | |
Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
Corneal abrasion | indication | 85848002 | |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Uveitis | indication | 128473001 | DOID:13141 |
Infective blepharitis | indication | 312219000 | |
Bacterial keratitis | indication | 314557000 | |
Superficial Ocular Infection | indication | ||
Minor Bacterial Skin Infections | indication | ||
Minor Skin Wound Pain | indication | ||
Mastoidectomy Cavity Infections | indication | ||
H. Influenzae Meningitis | indication | ||
Chronic purulent otitis media | off-label use | 38394007 | DOID:14247 |
Dacryocystitis | off-label use | 85777005 | DOID:9938 |
Corneal ulcer | off-label use | 91514001 | DOID:8463 |
Meibomianitis | off-label use | 309779001 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Herpes simplex keratitis | contraindication | 9389005 | |
Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
Herpes simplex dendritic keratitis | contraindication | 29943008 | |
Fungal infection of eye | contraindication | 31194008 | |
Bullous myringitis | contraindication | 33528003 | DOID:13791 |
Dehydration | contraindication | 34095006 | |
Severe myopia | contraindication | 34187009 | |
Tuberculosis of eye | contraindication | 49107007 | |
Neuromuscular block, function | contraindication | 55394004 | |
Perforation of tympanic membrane | contraindication | 60442001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Third degree burn injury | contraindication | 80247002 | |
Oliguria | contraindication | 83128009 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Krukenberg spindle | contraindication | 85430004 | |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Procedure on urinary system | contraindication | 118677009 | |
Open wound | contraindication | 125643001 | |
Eye infection | contraindication | 128351009 | |
Hearing disorder | contraindication | 128540005 | |
Bacterial infection of eye | contraindication | 128984004 | |
Tuberculosis of ear | contraindication | 186269001 | |
Telangiectasia disorder | contraindication | 247479008 | |
Rupture of bladder | contraindication | 251925007 | |
Injury of eye region | contraindication | 282752000 | |
Pregnancy, function | contraindication | 289908002 | |
Viral eye infection | contraindication | 312132001 | |
Viral ear infection | contraindication | 312137007 | |
Fungal ear infection | contraindication | 312148000 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Vaccinia keratitis | contraindication | 397552005 | |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 |
Species | Use | Relation |
---|---|---|
Cats | Inflammation associated with topical ophthalmological conditions of the eye | Indication |
Cats | Edema associated with topical ophthalmological conditions of the eye | Indication |
Cats | Secondary bacterial infections associated with topical ophthalmological conditions of the eye | Indication |
Cattle | Superficial ocular infections | Indication |
Cattle | Infections caused by streptococci | Indication |
Cattle | Infections caused by rickettsiae | Indication |
Cattle | Infections caused by Escherichia coli | Indication |
Cattle | Infections caused by A aerogenes | Indication |
Dogs | Inflammation associated with topical ophthalmological conditions of the eye | Indication |
Dogs | Edema associated with topical ophthalmological conditions of the eye | Indication |
Dogs | Secondary bacterial infections associated with topical ophthalmological conditions of the eye | Indication |
Horses | Inflammation associated with topical ophthalmological conditions of the eye | Indication |
Horses | Edema associated with topical ophthalmological conditions of the eye | Indication |
Horses | Secondary bacterial infections associated with topical ophthalmological conditions of the eye | Indication |
Sheep | Inflammation associated with topical ophthalmological conditions of the eye | Indication |
Sheep | Edema associated with topical ophthalmological conditions of the eye | Indication |
Sheep | Secondary bacterial infections associated with topical ophthalmological conditions of the eye | Indication |
Product | Applicant | Ingredients |
---|---|---|
Terramycin Ophthalmic Ointment with Polymyxin | Zoetis Inc. | 2 |
Anaprime Ophthalmic Solution | Zoetis Inc. | 3 |
Anaprime Opthakote Ophthalmic | Zoetis Inc. | 3 |
Optiprime Opthakote Ophthalmic Solution | Zoetis Inc. | 2 |
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment | Dechra, Ltd. | 4 |
Bac-Neo-Poly Ophthalmic Ointment, Vetropolycin Ophthalmic Ointment | Dechra, Ltd. | 3 |
Mycitracin Sterile Ophthalmic Ointment | Zoetis Inc. | 3 |
Forte Topical Ointment | Zoetis Inc. | 4 |
Cortisporin Veterinary Ophthalmic Ointment | Intervet Inc. | 4 |
Neosporin Ophthalmic Ointment | Intervet Inc. | 3 |
Surolan | Elanco US Inc. | 3 |
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment | Akorn Animal Health Inc. | 3 |
None
None
None
None
ID | Source |
---|---|
4018100 | VUID |
N0000146438 | NUI |
D08401 | KEGG_DRUG |
1404-26-8 | SECONDARY_CAS_RN |
4018100 | VANDF |
4018594 | VANDF |
C0032535 | UMLSCUI |
CHEBI:8310 | CHEBI |
CHEMBL3989738 | ChEMBL_ID |
CHEMBL3989714 | ChEMBL_ID |
D011112 | MESH_DESCRIPTOR_UI |
DB00781 | DRUGBANK_ID |
10338 | IUPHAR_LIGAND_ID |
490 | INN_ID |
J2VZ07J96K | UNII |
4868 | PUBCHEM_CID |
202404 | RXNORM |
1703 | MMSL |
5317 | MMSL |
5318 | MMSL |
d00344 | MMSL |
002803 | NDDF |
004902 | NDDF |
372824005 | SNOMEDCT_US |
61360007 | SNOMEDCT_US |
6960003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Polytrim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-7824 | SOLUTION/ DROPS | 100000 [USPU] | OPHTHALMIC | NDA | 19 sections |
Polytrim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-7824 | SOLUTION/ DROPS | 100000 [USPU] | OPHTHALMIC | NDA | 19 sections |
MAXITROL | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0065-0631 | OINTMENT | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
MAXITROL | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0771 | OINTMENT | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
MAXITROL | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0771 | OINTMENT | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
Good Sense First Aid Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0113-0084 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Good Sense Triple Antibioticand Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-0679 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
basic care first aid antibiotic | HUMAN OTC DRUG LABEL | 3 | 0113-0701 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
good sense triple antibiotic | HUMAN OTC DRUG LABEL | 4 | 0113-1140 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Basic Care First Aid Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-7679 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Polymyxin B | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9941 | INJECTION, POWDER, FOR SOLUTION | 500000 [iU] | INTRAMUSCULAR | ANDA | 14 sections |
Bacitracin Zinc and Polymyxin B Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0168-0273 | OINTMENT | 10000 1 | OPHTHALMIC | ANDA | 17 sections |
Kaiser PermanenteDouble antibiotic | HUMAN OTC DRUG LABEL | 2 | 0179-8707 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 14 sections |
AntibioticMaximum Strength | HUMAN OTC DRUG LABEL | 3 | 0363-0018 | OINTMENT | 10000 [iU] | TOPICAL | OTC monograph final | 13 sections |
Triple Antibiotic with Pain ReliefMaximum Strength | HUMAN OTC DRUG LABEL | 4 | 0363-0123 | OINTMENT | 10000 [USPU] | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0179 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 13 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0179 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 13 sections |
triple antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0539 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 15 sections |
triple antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0539 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 15 sections |
triple antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0539 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 15 sections |
First Aid Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-0841 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
First Aid Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-0841 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Walgreens Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-2016 | OINTMENT | 5000 [iU] | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
Walgreens Multi-Antibiotic with Pain Relief Cream | HUMAN OTC DRUG LABEL | 3 | 0363-2123 | CREAM | 10000 [USPU] | TOPICAL | OTC monograph not final | 9 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-2900 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Walgreens Maximum Strength Triple Antibiotic With Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-7872 | OINTMENT | 1000 [USPU] | TOPICAL | OTC monograph final | 11 sections |
Walgreens Wal-Sporin First Aid Antibiotic | HUMAN OTC DRUG LABEL | 2 | 0363-8821 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 12 sections |
Triple Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-8888 | OINTMENT | 10000 [USPU] | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
Bacitracin Zinc, Neomycin Sulfate, and Polymyxin B Sulfate | HUMAN OTC DRUG LABEL | 3 | 0404-0167 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 12 sections |
Bacitracin Zinc, Polymyxin B Sulfate, and Neomycin Sulfate | HUMAN OTC DRUG LABEL | 3 | 0404-0171 | OINTMENT | 50000 [iU] | TOPICAL | OTC monograph final | 12 sections |