Polymyxin B 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4246 1405-20-5

Description:

MoleculeDescription

Synonyms:

  • Polymyxin B sulfate
  • aerosporin
  • mastimyxin
  • Polymyxin B
A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.
  • Molecular weight: 2392.97
  • Formula: C111H194N32O26
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 490.66
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 MU O
0.15 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 26, 1957 FDA MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 349.00 16.44 227 3879 274978 56012983
Macular degeneration 226.74 16.44 75 4031 18833 56269128
Respiratory failure 38.94 16.44 41 4065 95021 56192940
Drug ineffective 33.88 16.44 144 3962 918845 55369116
Cytomegalovirus test positive 32.97 16.44 11 4095 2815 56285146
Septic arthritis staphylococcal 30.96 16.44 7 4099 419 56287542
Sepsis 26.35 16.44 41 4065 139799 56148162
Lymphatic disorder 26.31 16.44 6 4100 373 56287588
Engraft failure 21.35 16.44 5 4101 350 56287611

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 39.82 18.27 46 3719 72553 31621026
Respiratory paralysis 33.77 18.27 6 3759 61 31693518
Mucosal disorder 30.25 18.27 10 3755 1524 31692055
Disseminated intravascular coagulation 28.88 18.27 22 3743 20515 31673064
Chronic graft versus host disease 23.07 18.27 11 3754 4381 31689198
Pathogen resistance 20.97 18.27 13 3752 8688 31684891
Hepatic function abnormal 20.71 18.27 25 3740 41197 31652382
Drug resistance 20.30 18.27 19 3746 23434 31670145
Trichosporon infection 19.79 18.27 6 3759 691 31692888
Bacterial translocation 19.36 18.27 5 3760 320 31693259
Acute graft versus host disease in skin 19.16 18.27 10 3755 4822 31688757

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 184.65 14.93 170 6486 262289 70659499
Respiratory failure 42.81 14.93 65 6591 168670 70753118
Drug resistance 39.53 14.93 31 6625 38159 70883629
Cytomegalovirus test positive 39.46 14.93 16 6640 5492 70916296
Respiratory paralysis 35.18 14.93 6 6650 61 70921727
Sepsis 33.46 14.93 72 6584 244473 70677315
Engraftment syndrome 30.09 14.93 9 6647 1255 70920533
Disseminated intravascular coagulation 29.95 14.93 25 6631 33573 70888215
Pathogen resistance 28.69 14.93 17 6639 13262 70908526
Hepatic function abnormal 26.03 14.93 32 6624 67964 70853824
Lymphatic disorder 25.54 14.93 6 6650 329 70921459
Septic arthritis staphylococcal 25.25 14.93 7 6649 745 70921043
Multiple organ dysfunction syndrome 24.98 14.93 40 6616 108475 70813313
Febrile neutropenia 23.30 14.93 56 6600 204262 70717526
Renal injury 23.29 14.93 16 6640 16078 70905710
Chronic graft versus host disease 21.01 14.93 11 6645 6759 70915029
Slow response to stimuli 19.50 14.93 7 6649 1726 70920062
Trichosporon infection 19.28 14.93 6 6650 955 70920833
Mucosal disorder 18.57 14.93 8 6648 3190 70918598
Platelet count decreased 18.36 14.93 47 6609 178175 70743613
Bacterial translocation 18.05 14.93 5 6651 531 70921257
Drug interaction 17.43 14.93 7 6649 381434 70540354
Tachypnoea 17.06 14.93 17 6639 28621 70893167
Mental status changes 16.96 14.93 25 6631 63076 70858712
Unevaluable event 16.01 14.93 22 6634 52041 70869747
Pyrexia 15.74 14.93 104 6552 606848 70314940
Skin hyperpigmentation 15.57 14.93 9 6647 6706 70915082
Blood chloride increased 15.23 14.93 8 6648 4945 70916843
Anaphylactic reaction 15.05 14.93 26 6630 74948 70846840
Corneal abrasion 14.94 14.93 5 6651 1001 70920787

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AA05 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC J01XB02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Polymyxins
ATC S01AA18 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
ATC S02AA11 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA03 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
FDA CS M0017217 Polymyxins
FDA EPC N0000175499 Polymyxin-class Antibacterial
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Keratitis indication 5888003 DOID:4677
Bacterial septicemia indication 10001005 DOID:0040085
Urinary tract infectious disease indication 68566005
Blepharoconjunctivitis indication 68659002 DOID:2456
Corneal abrasion indication 85848002
Bacterial conjunctivitis indication 128350005 DOID:9700
Uveitis indication 128473001 DOID:13141
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Superficial Ocular Infection indication
Minor Bacterial Skin Infections indication
Minor Skin Wound Pain indication
Mastoidectomy Cavity Infections indication
H. Influenzae Meningitis indication
Chronic purulent otitis media off-label use 38394007 DOID:14247
Dacryocystitis off-label use 85777005 DOID:9938
Corneal ulcer off-label use 91514001 DOID:8463
Meibomianitis off-label use 309779001
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Herpes zoster auricularis contraindication 21954000 DOID:9210
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Bullous myringitis contraindication 33528003 DOID:13791
Dehydration contraindication 34095006
Severe myopia contraindication 34187009
Tuberculosis of eye contraindication 49107007
Neuromuscular block, function contraindication 55394004
Perforation of tympanic membrane contraindication 60442001
Diabetes mellitus contraindication 73211009 DOID:9351
Third degree burn injury contraindication 80247002
Oliguria contraindication 83128009
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Procedure on urinary system contraindication 118677009
Open wound contraindication 125643001
Eye infection contraindication 128351009
Hearing disorder contraindication 128540005
Bacterial infection of eye contraindication 128984004
Tuberculosis of ear contraindication 186269001
Telangiectasia disorder contraindication 247479008
Rupture of bladder contraindication 251925007
Injury of eye region contraindication 282752000
Pregnancy, function contraindication 289908002
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Vaccinia keratitis contraindication 397552005
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation associated with topical ophthalmological conditions of the eye Indication
Cats Edema associated with topical ophthalmological conditions of the eye Indication
Cats Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication
Cattle Superficial ocular infections Indication
Cattle Infections caused by streptococci Indication
Cattle Infections caused by rickettsiae Indication
Cattle Infections caused by Escherichia coli Indication
Cattle Infections caused by A aerogenes Indication
Dogs Inflammation associated with topical ophthalmological conditions of the eye Indication
Dogs Edema associated with topical ophthalmological conditions of the eye Indication
Dogs Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication
Horses Inflammation associated with topical ophthalmological conditions of the eye Indication
Horses Edema associated with topical ophthalmological conditions of the eye Indication
Horses Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication
Sheep Inflammation associated with topical ophthalmological conditions of the eye Indication
Sheep Edema associated with topical ophthalmological conditions of the eye Indication
Sheep Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication

🐶 Veterinary products

ProductApplicantIngredients
Terramycin Ophthalmic Ointment with Polymyxin Zoetis Inc. 2
Anaprime Ophthalmic Solution Zoetis Inc. 3
Anaprime Opthakote Ophthalmic Zoetis Inc. 3
Optiprime Opthakote Ophthalmic Solution Zoetis Inc. 2
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment Dechra, Ltd. 4
Bac-Neo-Poly Ophthalmic Ointment, Vetropolycin Ophthalmic Ointment Dechra, Ltd. 3
Mycitracin Sterile Ophthalmic Ointment Zoetis Inc. 3
Forte Topical Ointment Zoetis Inc. 4
Cortisporin Veterinary Ophthalmic Ointment Intervet Inc. 4
Neosporin Ophthalmic Ointment Intervet Inc. 3
Surolan Elanco US Inc. 3
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment Akorn Animal Health Inc. 3

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018100 VUID
N0000146438 NUI
D08401 KEGG_DRUG
1404-26-8 SECONDARY_CAS_RN
4018100 VANDF
4018594 VANDF
C0032535 UMLSCUI
CHEBI:8310 CHEBI
CHEMBL3989738 ChEMBL_ID
CHEMBL3989714 ChEMBL_ID
D011112 MESH_DESCRIPTOR_UI
DB00781 DRUGBANK_ID
10338 IUPHAR_LIGAND_ID
490 INN_ID
J2VZ07J96K UNII
4868 PUBCHEM_CID
202404 RXNORM
1703 MMSL
5317 MMSL
5318 MMSL
d00344 MMSL
002803 NDDF
004902 NDDF
372824005 SNOMEDCT_US
61360007 SNOMEDCT_US
6960003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Polytrim HUMAN PRESCRIPTION DRUG LABEL 2 0023-7824 SOLUTION/ DROPS 100000 [USPU] OPHTHALMIC NDA 19 sections
Polytrim HUMAN PRESCRIPTION DRUG LABEL 2 0023-7824 SOLUTION/ DROPS 100000 [USPU] OPHTHALMIC NDA 19 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0065-0631 OINTMENT 10000 [USPU] OPHTHALMIC NDA 18 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0078-0771 OINTMENT 10000 [USPU] OPHTHALMIC NDA 18 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0078-0771 OINTMENT 10000 [USPU] OPHTHALMIC NDA 18 sections
Good Sense First Aid Antibiotic HUMAN OTC DRUG LABEL 3 0113-0084 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 13 sections
Good Sense Triple Antibioticand Pain Relief HUMAN OTC DRUG LABEL 4 0113-0679 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
basic care first aid antibiotic HUMAN OTC DRUG LABEL 3 0113-0701 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 13 sections
good sense triple antibiotic HUMAN OTC DRUG LABEL 4 0113-1140 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
Basic Care First Aid Antibiotic Plus Pain Relief HUMAN OTC DRUG LABEL 4 0113-7679 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
Polymyxin B HUMAN PRESCRIPTION DRUG LABEL 1 0143-9941 INJECTION, POWDER, FOR SOLUTION 500000 [iU] INTRAMUSCULAR ANDA 14 sections
Bacitracin Zinc and Polymyxin B Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0168-0273 OINTMENT 10000 1 OPHTHALMIC ANDA 17 sections
Kaiser PermanenteDouble antibiotic HUMAN OTC DRUG LABEL 2 0179-8707 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 14 sections
AntibioticMaximum Strength HUMAN OTC DRUG LABEL 3 0363-0018 OINTMENT 10000 [iU] TOPICAL OTC monograph final 13 sections
Triple Antibiotic with Pain ReliefMaximum Strength HUMAN OTC DRUG LABEL 4 0363-0123 OINTMENT 10000 [USPU] TOPICAL OTC MONOGRAPH FINAL 13 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-0179 OINTMENT 5000 [iU] TOPICAL OTC monograph final 13 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-0179 OINTMENT 5000 [iU] TOPICAL OTC monograph final 13 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 15 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 15 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 15 sections
First Aid Antibiotic HUMAN OTC DRUG LABEL 4 0363-0841 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
First Aid Antibiotic HUMAN OTC DRUG LABEL 4 0363-0841 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
Walgreens Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-2016 OINTMENT 5000 [iU] TOPICAL OTC MONOGRAPH FINAL 14 sections
Walgreens Multi-Antibiotic with Pain Relief Cream HUMAN OTC DRUG LABEL 3 0363-2123 CREAM 10000 [USPU] TOPICAL OTC monograph not final 9 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 4 0363-2900 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
Walgreens Maximum Strength Triple Antibiotic With Pain Relief HUMAN OTC DRUG LABEL 4 0363-7872 OINTMENT 1000 [USPU] TOPICAL OTC monograph final 11 sections
Walgreens Wal-Sporin First Aid Antibiotic HUMAN OTC DRUG LABEL 2 0363-8821 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 12 sections
Triple Antibiotic Plus Pain Relief HUMAN OTC DRUG LABEL 4 0363-8888 OINTMENT 10000 [USPU] TOPICAL OTC MONOGRAPH FINAL 14 sections
Bacitracin Zinc, Neomycin Sulfate, and Polymyxin B Sulfate HUMAN OTC DRUG LABEL 3 0404-0167 OINTMENT 5000 [iU] TOPICAL OTC monograph final 12 sections
Bacitracin Zinc, Polymyxin B Sulfate, and Neomycin Sulfate HUMAN OTC DRUG LABEL 3 0404-0171 OINTMENT 50000 [iU] TOPICAL OTC monograph final 12 sections