Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4246	1405-20-5

Description:

Molecule	Description
Synonyms: Polymyxin B sulfate aerosporin mastimyxin Polymyxin B	A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic. Molecular weight: 2392.97 Formula: C111H194N32O26 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 490.66 ALOGS: ROTB: None

Molecule

Description

Synonyms:

Polymyxin B sulfate
aerosporin
mastimyxin
Polymyxin B

A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.

Molecular weight: 2392.97
Formula: C111H194N32O26
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 490.66
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
3	MU	O
0.15	g	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
March 26, 1957	FDA	MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Local anaesthetic systemic toxicity	859.88	9.15	253	81413	3247	90543534
Maternal exposure during delivery	312.45	9.15	121	81545	3725	90543056
Nasal oedema	262.00	9.15	125	81541	6459	90540322
Anaphylactic reaction	250.87	9.15	350	81316	87174	90459607
Pemphigus	238.37	9.15	14	81652	326850	90219931
Anaphylactic shock	238.18	9.15	210	81456	31407	90515374
Cardiac arrest	238.07	9.15	376	81290	104559	90442222
Hand deformity	224.61	9.15	10	81656	296352	90250429
Toxic anterior segment syndrome	223.46	9.15	82	81584	2168	90544613
Glossodynia	214.27	9.15	21	81645	321758	90225023
Systemic lupus erythematosus	209.10	9.15	37	81629	361859	90184922
Synovitis	208.25	9.15	26	81640	329726	90217055
Respiratory tract infection	197.95	9.15	255	81411	58823	90487958
Contraindicated product administered	193.27	9.15	29	81637	320110	90226671
Anti-cyclic citrullinated peptide antibody positive	182.40	9.15	7	81659	236426	90310355
Pericarditis	171.28	9.15	21	81645	270130	90276651
Kounis syndrome	168.00	9.15	69	81597	2484	90544297
Duodenal ulcer perforation	165.90	9.15	8	81658	221280	90325501
Hepatic enzyme increased	164.11	9.15	60	81606	360676	90186105
Arthropathy	155.03	9.15	68	81598	366174	90180607
Wound	154.61	9.15	41	81625	302939	90243842
Joint swelling	150.76	9.15	139	81527	503161	90043620
Methaemoglobinaemia	149.98	9.15	73	81593	3942	90542839
Infusion site pain	134.65	9.15	124	81542	19614	90527167
Folliculitis	134.25	9.15	14	81652	204339	90342442
Helicobacter infection	131.37	9.15	23	81643	226827	90319954
Hypotension	129.22	9.15	608	81058	324789	90221992
Generalised tonic-clonic seizure	126.97	9.15	157	81509	34746	90512035
Sinusitis	126.84	9.15	628	81038	342460	90204321
Drug intolerance	121.02	9.15	135	81531	447456	90099325
Rheumatoid factor positive	120.21	9.15	9	81657	171641	90375140
Infusion site swelling	117.75	9.15	92	81574	11628	90535153
General physical health deterioration	114.89	9.15	91	81575	355024	90191757
Anaesthetic complication	114.20	9.15	52	81614	2413	90544368
Muscle injury	111.28	9.15	14	81652	176640	90370141
Abdominal discomfort	110.38	9.15	162	81504	477166	90069615
Stress cardiomyopathy	109.24	9.15	93	81573	13262	90533519
Liver injury	108.71	9.15	13	81653	170554	90376227
Insurance issue	107.89	9.15	85	81581	10873	90535908
Rheumatic fever	107.30	9.15	8	81658	153113	90393668
Alopecia	105.01	9.15	178	81488	494893	90051888
Impaired healing	104.69	9.15	40	81626	234159	90312622
Psoriatic arthropathy	102.06	9.15	39	81627	228296	90318485
Pulseless electrical activity	100.48	9.15	75	81591	8857	90537924
Infusion site extravasation	99.30	9.15	79	81587	10249	90536532
Macular degeneration	97.24	9.15	144	81522	37826	90508955
Blister	96.33	9.15	55	81611	254943	90291838
Infusion site erythema	95.42	9.15	87	81579	13583	90533198
Infusion site pruritus	94.96	9.15	65	81601	6700	90540081
Bradycardia	91.88	9.15	221	81445	83626	90463155
Type 2 diabetes mellitus	85.51	9.15	38	81628	203206	90343575
Sleep disorder due to general medical condition, insomnia type	84.03	9.15	9	81657	128685	90418096
Seizure	82.11	9.15	313	81353	152316	90394465
Therapeutic product effect decreased	81.42	9.15	78	81588	277493	90269288
Urinary tract infection	80.61	9.15	511	81155	305121	90241660
Mobility decreased	78.88	9.15	66	81600	250668	90296113
COVID-19	75.53	9.15	327	81339	168516	90378265
Irritable bowel syndrome	75.17	9.15	47	81619	207401	90339380
Illness	74.18	9.15	201	81465	81768	90465013
Infusion site haemorrhage	73.61	9.15	51	81615	5360	90541421
Ill-defined disorder	72.54	9.15	38	81628	184853	90361928
Swollen joint count increased	72.04	9.15	8	81658	111198	90435583
Procedural hypotension	71.76	9.15	33	81633	1567	90545214
Infusion site bruising	71.00	9.15	46	81620	4326	90542455
C-reactive protein abnormal	69.36	9.15	15	81651	127414	90419367
Facet joint syndrome	69.33	9.15	5	81661	98384	90448397
Swelling	69.05	9.15	174	81492	418884	90127897
Musculoskeletal stiffness	67.14	9.15	102	81564	296430	90250351
Pulse absent	66.23	9.15	50	81616	6005	90540776
Lip dry	66.06	9.15	7	81659	100948	90445833
Toxicity to various agents	64.91	9.15	463	81203	287383	90259398
Lower respiratory tract infection	64.01	9.15	79	81587	250580	90296201
Corneal oedema	63.40	9.15	32	81634	1869	90544912
Hypersensitivity	63.02	9.15	205	81461	454472	90092309
Anaesthetic complication neurological	62.64	9.15	24	81642	717	90546064
Rheumatoid arthritis	61.74	9.15	148	81518	362466	90184315
Product dose omission issue	60.53	9.15	460	81206	291227	90255554
Apnoea	60.08	9.15	57	81609	9357	90537424
Incorrect drug administration rate	59.07	9.15	44	81622	5179	90541602
Sulphaemoglobinaemia	58.82	9.15	21	81645	512	90546269
Bursitis	57.96	9.15	23	81643	131631	90415150
Peripheral venous disease	57.07	9.15	5	81661	83916	90462865
Staphylococcal infection	56.67	9.15	131	81535	48308	90498473
Seasonal allergy	55.76	9.15	85	81581	22898	90523883
Systemic toxicity	55.07	9.15	17	81649	259	90546522
Inflammation	54.94	9.15	48	81618	178544	90368237
Blood cholesterol increased	54.76	9.15	64	81602	207948	90338833
Mental status changes	54.67	9.15	123	81543	44556	90502225
Ventricular tachycardia	53.86	9.15	87	81579	24621	90522160
Bronchitis	53.62	9.15	276	81390	152651	90394130
Product adhesion issue	53.03	9.15	41	81625	5101	90541680
Unresponsive to stimuli	52.41	9.15	110	81556	38011	90508770
Gait inability	51.92	9.15	34	81632	146422	90400359
Infusion site urticaria	51.78	9.15	27	81639	1688	90545093
Fear	51.39	9.15	69	81597	16553	90530228
Drug ineffective for unapproved indication	51.13	9.15	154	81512	66490	90480291
Sleep disorder	50.99	9.15	62	81604	197968	90348813
Completed suicide	50.98	9.15	34	81632	145024	90401757
Ventricular fibrillation	50.79	9.15	63	81603	13981	90532800
Neurotoxicity	50.12	9.15	78	81588	21389	90525392
Septic arthritis staphylococcal	49.89	9.15	19	81647	558	90546223
Extradural abscess	49.58	9.15	24	81642	1280	90545501
Status epilepticus	48.92	9.15	72	81594	18802	90527979
Obesity	48.85	9.15	17	81649	105490	90441291
Emotional distress	48.33	9.15	104	81562	36558	90510223
Dermatitis contact	47.59	9.15	60	81606	13535	90533246
Cough	47.08	9.15	524	81142	368438	90178343
Extradural haematoma	47.05	9.15	27	81639	2041	90544740
Upper respiratory tract infection	46.67	9.15	234	81432	128084	90418697
Stomatitis	43.72	9.15	116	81550	274582	90272199
Treatment failure	43.49	9.15	135	81531	303793	90242988
Grip strength decreased	42.71	9.15	15	81651	92561	90454220
Administration site pain	42.56	9.15	21	81645	1168	90545613
Lagophthalmos	42.47	9.15	16	81650	456	90546325
Anterior chamber cell	42.08	9.15	18	81648	718	90546063
Peripheral nerve injury	42.01	9.15	18	81648	721	90546060
Abdominal pain upper	41.36	9.15	157	81509	332517	90214264
Product use issue	40.82	9.15	156	81510	329763	90217018
Infusion site mass	40.47	9.15	25	81641	2164	90544617
Fibromyalgia	40.21	9.15	78	81588	206191	90340590
Arthralgia	39.68	9.15	480	81186	778042	89768739
Adjustment disorder with depressed mood	39.65	9.15	3	81663	56750	90490031
Deep vein thrombosis postoperative	39.21	9.15	8	81658	70801	90475980
Premature delivery	39.09	9.15	99	81567	38663	90508118
Endophthalmitis	39.08	9.15	33	81633	4652	90542129
Confusional state	39.05	9.15	197	81469	386008	90160773
Inappropriate schedule of product administration	39.04	9.15	250	81416	149683	90397098
Condition aggravated	39.01	9.15	346	81320	595199	89951582
Renal injury	38.74	9.15	47	81619	10196	90536585
Prescribed underdose	38.51	9.15	10	81656	75009	90471772
Hypopyon	38.35	9.15	18	81648	896	90545885
Type I hypersensitivity	38.28	9.15	31	81635	4124	90542657
Pulmonary fibrosis	38.04	9.15	25	81641	107478	90439303
Embolia cutis medicamentosa	37.67	9.15	16	81650	627	90546154
Spinal epidural haemorrhage	37.58	9.15	13	81653	288	90546493
Spinal epidural haematoma	37.44	9.15	20	81646	1314	90545467
Ear infection	37.42	9.15	143	81523	69632	90477149
Unevaluable event	36.79	9.15	121	81545	54727	90492054
Musculoskeletal pain	36.75	9.15	61	81605	171190	90375591
Discomfort	36.38	9.15	126	81540	274209	90272572
Bronchospasm	36.05	9.15	66	81600	20643	90526138
Liver disorder	35.62	9.15	34	81632	121235	90425546
Tachycardia	35.14	9.15	253	81413	157420	90389361
Bursitis infective	35.12	9.15	20	81646	1490	90545291
Pneumocephalus	35.07	9.15	12	81654	257	90546524
Osteoarthritis	34.79	9.15	78	81588	195652	90351129
Nail disorder	34.14	9.15	6	81660	59061	90487720
C-reactive protein increased	34.14	9.15	70	81596	181319	90365462
Hypercholesterolaemia	33.67	9.15	25	81641	100867	90445914
Infusion site discharge	33.24	9.15	23	81643	2412	90544369
Anhedonia	33.15	9.15	46	81620	11385	90535396
Infusion site rash	32.83	9.15	23	81643	2460	90544321
Prescribed overdose	32.82	9.15	24	81642	97601	90449180
Respiratory depression	32.81	9.15	54	81612	15521	90531260
Knee arthroplasty	32.75	9.15	17	81649	83165	90463616
Paraplegia	32.59	9.15	26	81640	3386	90543395
Kidney infection	32.44	9.15	72	81594	25844	90520937
Night sweats	32.41	9.15	41	81625	128725	90418056
Wound infection	32.23	9.15	29	81637	106373	90440408
Vascular malformation	32.14	9.15	15	81651	737	90546044
Lung disorder	31.60	9.15	54	81612	149829	90396952
Cauda equina syndrome	31.51	9.15	18	81648	1349	90545432
Joint range of motion decreased	31.31	9.15	46	81620	135597	90411184
Vitritis	31.28	9.15	19	81647	1595	90545186
Blepharospasm	31.26	9.15	6	81660	55439	90491342
Multiple allergies	31.21	9.15	52	81614	15094	90531687
Paranasal cyst	31.08	9.15	15	81651	795	90545986
Hip arthroplasty	30.87	9.15	15	81651	76193	90470588
Stridor	30.55	9.15	29	81637	4764	90542017
Anal skin tags	30.42	9.15	14	81652	666	90546115
Meningitis chemical	30.29	9.15	11	81655	282	90546499
Headache	30.27	9.15	1003	80663	861743	89685038
Infusion site nodule	30.14	9.15	19	81647	1704	90545077
Sinus tachycardia	29.99	9.15	74	81592	28439	90518342
Spinal cord compression	29.95	9.15	29	81637	4882	90541899
Myelosuppression	29.79	9.15	6	81660	53585	90493196
Parophthalmia	29.78	9.15	12	81654	411	90546370
Infusion related reaction	29.58	9.15	237	81429	416543	90130238
Epidural haemorrhage	29.55	9.15	11	81655	303	90546478
Fear of eating	29.53	9.15	12	81654	420	90546361
Drug hypersensitivity	29.23	9.15	583	81083	463026	90083755
Chills	28.95	9.15	211	81455	131770	90415011
Purtscher retinopathy	28.92	9.15	9	81657	141	90546640
Eyelid ptosis	28.79	9.15	38	81628	8968	90537813
Oedema	28.56	9.15	291	81375	200004	90346777
Corneal epithelium defect	28.05	9.15	12	81654	479	90546302
Peripheral swelling	27.91	9.15	238	81428	412868	90133913
Pneumonia	27.79	9.15	762	80904	637297	89909484
Ophthalmoplegia	27.42	9.15	18	81648	1731	90545050
Administration site swelling	27.41	9.15	17	81649	1482	90545299
Bone erosion	27.34	9.15	7	81659	53014	90493767
Incorrect route of product administration	27.34	9.15	104	81562	50522	90496259
Cardiogenic shock	27.33	9.15	65	81601	24403	90522378
Hypoxia	27.00	9.15	133	81533	72266	90474515
Platelet aggregation inhibition	26.88	9.15	9	81657	180	90546601
Dry mouth	26.85	9.15	81	81585	183978	90362803
Aqueous fibrin	26.34	9.15	8	81658	115	90546666
Bundle branch block left	26.34	9.15	34	81632	7851	90538930
Skin infection	26.26	9.15	53	81613	17811	90528970
Localised infection	26.16	9.15	78	81588	33484	90513297
Adverse event	25.96	9.15	41	81625	117377	90429404
Stress	25.85	9.15	143	81523	81252	90465529
Drug-induced liver injury	25.74	9.15	26	81640	90292	90456489
Hepatitis	25.64	9.15	16	81650	70723	90476058
Red blood cell sedimentation rate increased	25.63	9.15	22	81644	82573	90464208
Punctate keratitis	25.38	9.15	13	81653	783	90545998
Medical device site cellulitis	25.30	9.15	9	81657	217	90546564
Loss of personal independence in daily activities	25.21	9.15	53	81613	136052	90410729
Trigeminal palsy	24.93	9.15	7	81659	75	90546706
Hepatic cirrhosis	24.80	9.15	13	81653	63240	90483541
Haemorrhoids	24.67	9.15	66	81600	26636	90520145
Retinal vasculitis	24.50	9.15	16	81650	1525	90545256
Circulatory collapse	24.48	9.15	63	81603	24841	90521940
Gastrointestinal disorder	24.21	9.15	134	81532	256553	90290228
Body tinea	24.08	9.15	18	81648	2130	90544651
Therapy partial responder	24.02	9.15	58	81608	21985	90524796
Otitis media	23.95	9.15	28	81638	5842	90540939
Onychomadesis	23.86	9.15	6	81660	45992	90500789
Back pain	23.85	9.15	410	81256	316765	90230016
Hypoaesthesia oral	23.79	9.15	47	81619	15553	90531228
Bacterial infection	23.77	9.15	60	81606	23384	90523397
Epidural analgesia	23.75	9.15	8	81658	163	90546618
Respiratory failure	23.54	9.15	185	81481	118233	90428548
Procedure aborted	23.53	9.15	8	81658	168	90546613
Lupus vulgaris	23.14	9.15	6	81660	45053	90501728
Paralysis	23.11	9.15	39	81627	11439	90535342
Foetal heart rate abnormal	23.07	9.15	13	81653	949	90545832
Sepsis	22.72	9.15	255	81411	179559	90367222
Ventricular hypokinesia	22.67	9.15	26	81640	5315	90541466
Diplopia	22.63	9.15	67	81599	28647	90518134
Upper airway obstruction	22.22	9.15	13	81653	1019	90545762
Infusion site discomfort	22.12	9.15	16	81650	1800	90544981
Medical device site abscess	22.11	9.15	8	81658	203	90546578
Neuromuscular block prolonged	21.82	9.15	11	81655	641	90546140
Visual acuity reduced	21.77	9.15	58	81608	23352	90523429
Post procedural complication	21.72	9.15	51	81615	18991	90527790
Infusion site warmth	21.67	9.15	17	81649	2161	90544620
Psoriasis	21.56	9.15	65	81601	147689	90399092
Anxiety	21.36	9.15	395	81271	309377	90237404
Gastroenteritis viral	21.29	9.15	68	81598	30287	90516494
Chemical burn	21.17	9.15	10	81656	505	90546276
Nephrolithiasis	21.11	9.15	94	81572	48991	90497790
Weight increased	21.10	9.15	258	81408	417669	90129112
Mastoiditis	21.00	9.15	15	81651	1655	90545126
Product distribution issue	20.96	9.15	21	81645	3684	90543097
Nystagmus	20.83	9.15	29	81637	7198	90539583
Nerve root injury	20.83	9.15	6	81660	71	90546710
Cardio-respiratory arrest	20.77	9.15	112	81554	63028	90483753
Foetal exposure during delivery	20.76	9.15	9	81657	371	90546410
Viral infection	20.68	9.15	83	81583	41331	90505450
Vitamin D increased	20.59	9.15	12	81654	934	90545847
Asthenia	20.46	9.15	348	81318	533403	90013378
Atonic urinary bladder	20.41	9.15	7	81659	151	90546630
Ventricular extrasystoles	20.31	9.15	40	81626	13210	90533571
Airway peak pressure increased	19.94	9.15	9	81657	409	90546372
Spinal anaesthesia	19.90	9.15	6	81660	84	90546697
Autoimmune disorder	19.77	9.15	24	81642	76720	90470061
Hyperthermia malignant	19.48	9.15	13	81653	1285	90545496
Monoplegia	19.28	9.15	20	81646	3654	90543127
Meningitis aseptic	19.26	9.15	27	81639	6746	90540035
Mydriasis	19.12	9.15	42	81624	14970	90531811
Procedural complication	19.09	9.15	25	81641	5853	90540928
Infusion site discolouration	19.03	9.15	12	81654	1077	90545704
Iron binding capacity total decreased	19.01	9.15	9	81657	457	90546324
Nerve block	18.90	9.15	11	81655	854	90545927
Cellulitis	18.88	9.15	144	81522	91193	90455588
Poor venous access	18.79	9.15	49	81617	19478	90527303
Underdose	18.52	9.15	13	81653	54004	90492777
Procedural pain	18.40	9.15	69	81597	33291	90513490
Vocal cord dysfunction	18.34	9.15	11	81655	903	90545878
Retinitis	18.14	9.15	6	81660	38452	90508329
Normal newborn	17.93	9.15	54	81612	23308	90523473
Paraesthesia oral	17.90	9.15	66	81600	31593	90515188
Vasoplegia syndrome	17.88	9.15	17	81649	2797	90543984
Vascular stenosis	17.81	9.15	9	81657	527	90546254
Vaginal abscess	17.71	9.15	9	81657	533	90546248
Pulmonary oedema	17.71	9.15	106	81560	61974	90484807
Nail bed tenderness	17.59	9.15	8	81658	370	90546411
Haemodynamic instability	17.46	9.15	35	81631	11704	90535077
Erythema	17.46	9.15	297	81369	228949	90317832
Heliotrope rash	17.42	9.15	7	81659	238	90546543
Tinnitus	17.39	9.15	81	81585	43021	90503760
Arthritis bacterial	17.31	9.15	27	81639	7418	90539363
Abortion spontaneous	17.26	9.15	14	81652	54042	90492739
Transferrin decreased	17.20	9.15	8	81658	390	90546391
Blood pressure decreased	17.15	9.15	121	81545	74774	90472007
Delayed recovery from anaesthesia	17.13	9.15	11	81655	1019	90545762
Tremor	17.04	9.15	212	81454	152961	90393820
Epilepsy	16.97	9.15	30	81636	82176	90464605
Corneal abrasion	16.96	9.15	12	81654	1304	90545477
Retinal artery occlusion	16.93	9.15	15	81651	2256	90544525
Tenderness	16.89	9.15	58	81608	26810	90519971
Multiple organ dysfunction syndrome	16.59	9.15	112	81554	68224	90478557
Left ventricle outflow tract obstruction	16.57	9.15	8	81658	424	90546357
Infection susceptibility increased	16.48	9.15	19	81647	3907	90542874
Anaphylactoid shock	16.47	9.15	8	81658	430	90546351
Eye infarction	16.39	9.15	5	81661	73	90546708
Retinal detachment	16.22	9.15	25	81641	6797	90539984
Inhibitory drug interaction	16.21	9.15	17	81649	3146	90543635
Spinal synovial cyst	16.21	9.15	5	81661	76	90546705
Electrocardiogram ST segment elevation	16.13	9.15	19	81647	3997	90542784
Tachypnoea	16.11	9.15	49	81617	21260	90525521
Cystitis	15.99	9.15	109	81557	66609	90480172
Intercepted medication error	15.96	9.15	10	81656	887	90545894
Inadequate analgesia	15.94	9.15	17	81649	3207	90543574
Infusion site oedema	15.76	9.15	11	81655	1170	90545611
Chest pain	15.69	9.15	388	81278	319257	90227524
Poikiloderma	15.66	9.15	7	81659	311	90546470
Blood pressure abnormal	15.64	9.15	46	81620	19599	90527182
Apgar score low	15.57	9.15	11	81655	1192	90545589
Skin discolouration	15.53	9.15	80	81586	44235	90502546
Memory impairment	15.47	9.15	109	81557	197135	90349646
Quadriparesis	15.45	9.15	15	81651	2534	90544247
Acute respiratory failure	15.40	9.15	78	81588	42840	90503941
Administration site extravasation	15.35	9.15	11	81655	1219	90545562
Nasal mucosal disorder	15.33	9.15	13	81653	1844	90544937
Brain stem syndrome	15.27	9.15	9	81657	715	90546066
Conjunctival oedema	15.26	9.15	10	81656	959	90545822
Anal sphincter atony	15.15	9.15	7	81659	336	90546445
Apnoeic attack	15.15	9.15	7	81659	336	90546445
Allergy to immunoglobulin therapy	15.13	9.15	6	81660	197	90546584
Anorectal discomfort	15.00	9.15	16	81650	3018	90543763
Back injury	14.98	9.15	12	81654	46610	90500171
Coeliac disease	14.95	9.15	11	81655	44599	90502182
Intentional self-injury	14.88	9.15	4	81662	29330	90517451
Streptococcal infection	14.88	9.15	25	81641	7308	90539473
Limb injury	14.82	9.15	62	81604	31446	90515335
Sinusitis bacterial	14.82	9.15	13	81653	1930	90544851
Eyelid contusion	14.79	9.15	5	81661	103	90546678
Thrombocytopenia	14.64	9.15	119	81547	208606	90338175
C-reactive protein	14.61	9.15	5	81661	31362	90515419
Anaphylactoid reaction	14.51	9.15	19	81647	4449	90542332
Peripheral vascular disorder	14.50	9.15	23	81643	6408	90540373
Cancer pain	14.46	9.15	18	81648	4007	90542774
Influenza like illness	14.44	9.15	123	81543	80488	90466293
Orbital infection	14.40	9.15	5	81661	112	90546669
Asthma	14.39	9.15	302	81364	241858	90304923
Incontinence	14.27	9.15	35	81631	13400	90533381
Infusion site streaking	14.26	9.15	8	81658	579	90546202
Proctalgia	14.11	9.15	26	81640	8172	90538609
Sensory loss	14.08	9.15	42	81624	18033	90528748
Wrong product administered	14.07	9.15	25	81641	7640	90539141
Infusion site scar	14.02	9.15	8	81658	598	90546183
Akinesia	14.01	9.15	12	81654	1724	90545057
Body dysmorphic disorder	13.95	9.15	7	81659	404	90546377
Autonomic neuropathy	13.90	9.15	11	81655	1416	90545365
Procedural anxiety	13.88	9.15	9	81657	847	90545934
Product use in unapproved indication	13.88	9.15	399	81267	335837	90210944
Neonatal toxicity	13.84	9.15	4	81662	48	90546733
Axillary nerve injury	13.76	9.15	4	81662	49	90546732
Drug reaction with eosinophilia and systemic symptoms	13.75	9.15	11	81655	42747	90504034
Vision blurred	13.74	9.15	156	81510	110137	90436644
Implant site bruising	13.71	9.15	7	81659	419	90546362
Drug interaction	13.69	9.15	336	81330	276117	90270664
Anterior chamber fibrin	13.67	9.15	5	81661	131	90546650
Nail bed inflammation	13.63	9.15	12	81654	1789	90544992
Nausea	13.63	9.15	1169	80497	1109147	89437634
Pupillary reflex impaired	13.62	9.15	14	81652	2531	90544250
Diplegia	13.58	9.15	11	81655	1464	90545317
Electrocardiogram QRS complex prolonged	13.53	9.15	24	81642	7324	90539457
Influenza	13.51	9.15	188	81478	139076	90407705
Loss of consciousness	13.47	9.15	189	81477	140049	90406732
Lower limb fracture	13.43	9.15	36	81630	84977	90461804
Vascular resistance systemic decreased	13.42	9.15	5	81661	138	90546643
Administration site erythema	13.39	9.15	9	81657	900	90545881
Heparin-induced thrombocytopenia	13.39	9.15	20	81646	5292	90541489
Arthritis	13.35	9.15	92	81574	167223	90379558
Glucose tolerance impaired	13.33	9.15	25	81641	7960	90538821
Gastric mucosa erythema	13.29	9.15	7	81659	447	90546334
Hepatotoxicity	13.28	9.15	13	81653	45829	90500952
Obstruction	13.24	9.15	17	81649	3904	90542877
Sciatica	13.13	9.15	47	81619	101335	90445446
Taste disorder	13.13	9.15	22	81644	61524	90485257
Disseminated intravascular coagulation	13.11	9.15	46	81620	21492	90525289
Tooth infection	13.08	9.15	44	81622	20126	90526655
Spinal stroke	12.95	9.15	4	81662	61	90546720
Calcinosis	12.95	9.15	14	81652	2681	90544100
Rash	12.95	9.15	586	81080	795514	89751267
Cholestasis of pregnancy	12.93	9.15	11	81655	1566	90545215
Agitation	12.88	9.15	104	81562	66994	90479787
Immunodeficiency	12.83	9.15	12	81654	43222	90503559
Respiratory distress	12.75	9.15	69	81597	38877	90507904
Eclampsia	12.68	9.15	7	81659	491	90546290
Sinus disorder	12.64	9.15	63	81603	34384	90512397
Arthritis fungal	12.61	9.15	4	81662	67	90546714
Neuralgia	12.56	9.15	59	81607	31441	90515340
Pneumonia mycoplasmal	12.44	9.15	9	81657	1013	90545768
Metapneumovirus infection	12.38	9.15	10	81656	1325	90545456
Economic problem	12.32	9.15	15	81651	3266	90543515
Varicose vein	12.31	9.15	23	81643	7304	90539477
Hypoaesthesia	12.30	9.15	204	81462	314006	90232775
Allergy to metals	12.30	9.15	9	81657	1031	90545750
Intraocular pressure fluctuation	12.29	9.15	4	81662	73	90546708
Product preparation error	12.27	9.15	28	81638	10233	90536548
Infusion site irritation	12.26	9.15	10	81656	1343	90545438
Brain oedema	12.24	9.15	39	81627	17346	90529435
Trigemino-cardiac reflex	12.19	9.15	4	81662	75	90546706
Retinal haemorrhage	12.16	9.15	20	81646	5744	90541037
Papule	12.07	9.15	24	81642	7978	90538803
Genital ulceration	12.05	9.15	9	81657	1064	90545717
Fear-related avoidance of activities	12.02	9.15	5	81661	186	90546595
Phrenic nerve paralysis	11.99	9.15	6	81660	344	90546437
Liver function test abnormal	11.97	9.15	17	81649	50828	90495953
Orthostatic hypotension	11.96	9.15	12	81654	41815	90504966
Haemangioma congenital	11.96	9.15	7	81659	549	90546232
Liver function test increased	11.90	9.15	38	81628	84817	90461964
Cataract nuclear	11.89	9.15	9	81657	1085	90545696
Tryptase increased	11.83	9.15	7	81659	560	90546221
Depression	11.82	9.15	195	81471	300406	90246375
Spinal cord injury	11.78	9.15	9	81657	1100	90545681
Implant site swelling	11.78	9.15	7	81659	565	90546216
Neuromuscular blockade	11.74	9.15	6	81660	360	90546421
Macular oedema	11.69	9.15	18	81648	4891	90541890
Injection site abscess	11.64	9.15	10	81656	1444	90545337
Myocardial ischaemia	11.62	9.15	33	81633	13781	90533000
Accelerated idioventricular rhythm	11.59	9.15	4	81662	88	90546693
Injection site atrophy	11.59	9.15	8	81658	836	90545945
Gastrooesophageal reflux disease	11.59	9.15	95	81571	166242	90380539
Leukopenia	11.56	9.15	49	81617	100661	90446120
Onychomycosis	11.54	9.15	10	81656	37366	90509415
Tooth disorder	11.51	9.15	57	81609	31033	90515748
Labelled drug-drug interaction medication error	11.47	9.15	34	81632	14548	90532233
Quadriplegia	11.45	9.15	12	81654	2219	90544562
Haematocrit increased	11.44	9.15	14	81652	3064	90543717
Repetitive strain injury	11.40	9.15	5	81661	212	90546569
Mean arterial pressure decreased	11.38	9.15	5	81661	213	90546568
Road traffic accident	11.37	9.15	54	81612	107572	90439209
Cyanosis	11.37	9.15	41	81625	19414	90527367
Product contamination	11.26	9.15	9	81657	1175	90545606
Retinal cyst	11.22	9.15	4	81662	97	90546684
Encephalopathy	11.20	9.15	76	81590	46368	90500413
Renal failure	11.19	9.15	173	81493	130834	90415947
Application site alopecia	11.16	9.15	3	81663	27	90546754
Drug level increased	11.07	9.15	52	81614	27710	90519071
Productive cough	10.99	9.15	112	81554	76951	90469830
Haemorrhagic vasculitis	10.93	9.15	4	81662	105	90546676
Post procedural infection	10.87	9.15	28	81638	11046	90535735
Infusion related hypersensitivity reaction	10.83	9.15	7	81659	655	90546126
Carbon dioxide decreased	10.81	9.15	13	81653	2795	90543986
Central pain syndrome	10.76	9.15	7	81659	663	90546118
Hallucination, tactile	10.67	9.15	6	81660	436	90546345
Drug tolerance decreased	10.67	9.15	8	81658	32122	90514659
Product administration interrupted	10.67	9.15	30	81636	12462	90534319
Sympathectomy	10.61	9.15	3	81663	33	90546748
Coccygectomy	10.61	9.15	3	81663	33	90546748
Cerebral congestion	10.58	9.15	4	81662	115	90546666
Anorgasmia	10.48	9.15	7	81659	693	90546088
Vasospasm	10.45	9.15	8	81658	981	90545800
Suicide attempt	10.41	9.15	34	81632	75365	90471416
Pain	10.39	9.15	1037	80629	995304	89551477
Hordeolum	10.39	9.15	17	81649	4861	90541920
Cardiotoxicity	10.37	9.15	28	81638	11361	90535420
Myelitis	10.35	9.15	11	81655	2067	90544714
Meningoencephalitis bacterial	10.34	9.15	5	81661	266	90546515
Pharyngitis streptococcal	10.30	9.15	30	81636	12712	90534069
Moraxella infection	10.28	9.15	6	81660	468	90546313
Muscle tightness	10.25	9.15	31	81635	13408	90533373
White blood cell disorder	10.25	9.15	13	81653	2951	90543830
Disease progression	10.21	9.15	91	81575	156524	90390257
Foetal death	10.19	9.15	3	81663	20720	90526061
Incision site rash	10.16	9.15	3	81663	39	90546742
Pupil fixed	10.13	9.15	11	81655	2117	90544664
Conduction disorder	10.12	9.15	10	81656	1725	90545056
Incision site swelling	10.12	9.15	5	81661	279	90546502
Product contamination microbial	10.09	9.15	5	81661	281	90546500
Spinal osteoarthritis	10.06	9.15	39	81627	19109	90527672
Speech disorder	10.06	9.15	73	81593	45512	90501269
Eye infection	10.06	9.15	32	81634	14222	90532559
Lymphatic disorder	10.04	9.15	6	81660	489	90546292
Meningitis	9.99	9.15	23	81643	8458	90538323
Respiratory paralysis	9.95	9.15	3	81663	42	90546739
Lupus-like syndrome	9.93	9.15	18	81648	48828	90497953
Body temperature abnormal	9.89	9.15	12	81654	2603	90544178
Concussion	9.83	9.15	27	81639	11064	90535717
Spondylolisthesis	9.78	9.15	15	81651	4060	90542721
Streptococcal sepsis	9.76	9.15	14	81652	3570	90543211
Cardiac dysfunction	9.73	9.15	14	81652	3583	90543198
Device infusion issue	9.72	9.15	12	81654	2650	90544131
Poor quality sleep	9.66	9.15	46	81620	24647	90522134
Inability to afford medication	9.65	9.15	14	81652	3608	90543173
Laryngeal oedema	9.62	9.15	20	81646	6861	90539920
Candida infection	9.61	9.15	58	81608	33999	90512782
Lethargy	9.60	9.15	93	81573	63046	90483735
Neurogenic shock	9.60	9.15	6	81660	530	90546251
Anaesthetic complication cardiac	9.58	9.15	3	81663	48	90546733
Allergic cough	9.52	9.15	8	81658	1120	90545661
Immune thrombocytopenia	9.48	9.15	30	81636	13296	90533485
Supraventricular extrasystoles	9.46	9.15	17	81649	5240	90541541
Retrograde amnesia	9.42	9.15	6	81660	548	90546233
Oropharyngeal pain	9.41	9.15	151	81515	115036	90431745
Ischaemia	9.37	9.15	17	81649	5278	90541503
Femoral nerve injury	9.36	9.15	3	81663	52	90546729
Myelitis transverse	9.31	9.15	9	81657	1511	90545270
Parainfluenzae virus infection	9.23	9.15	12	81654	2791	90543990
Fanconi syndrome	9.18	9.15	10	81656	1933	90544848

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Local anaesthetic systemic toxicity	516.48	10.77	163	47399	2137	42571636
Anaphylactic shock	238.87	10.77	203	47359	23314	42550459
Anaphylactic reaction	218.95	10.77	254	47308	42489	42531284
Methaemoglobinaemia	194.59	10.77	105	47457	5669	42568104
Inspiratory capacity decreased	171.81	10.77	78	47484	2889	42570884
Cardiac arrest	141.43	10.77	350	47212	108970	42464803
Anaesthetic complication	122.95	10.77	50	47512	1407	42572366
Toxic anterior segment syndrome	103.97	10.77	44	47518	1372	42572401
Hypotension	103.68	10.77	563	46999	257068	42316705
Toxicity to various agents	97.80	10.77	509	47053	228627	42345146
Injury	95.28	10.77	121	47441	22195	42551578
Fear	92.04	10.77	85	47477	10880	42562893
Ventricular tachycardia	91.91	10.77	139	47423	30021	42543752
Drug ineffective	89.41	10.77	1083	46479	629114	41944659
Ventricular fibrillation	82.27	10.77	132	47430	29991	42543782
Renal injury	82.06	10.77	84	47478	12196	42561577
Bradycardia	81.73	10.77	245	47317	85239	42488534
Anhedonia	77.64	10.77	66	47496	7574	42566199
Generalised tonic-clonic seizure	76.75	10.77	119	47443	26260	42547513
Emotional distress	76.32	10.77	92	47470	16001	42557772
Drug ineffective for unapproved indication	66.27	10.77	154	47408	46009	42527764
Unresponsive to stimuli	60.38	10.77	118	47444	31285	42542488
Sinusitis	57.49	10.77	148	47414	47144	42526629
Electrocardiogram ST segment elevation	55.68	10.77	49	47513	5890	42567883
Tachycardia	50.44	10.77	235	47327	100852	42472921
Stress	47.31	10.77	132	47430	44080	42529693
Anal inflammation	47.19	10.77	30	47532	2199	42571574
Infusion site extravasation	46.99	10.77	43	47519	5438	42568335
Unevaluable event	44.48	10.77	110	47452	34178	42539595
Hyperthermia malignant	42.39	10.77	30	47532	2628	42571145
Infusion site pain	41.78	10.77	40	47522	5355	42568418
Adulterated product	40.78	10.77	19	47543	747	42573026
Insurance issue	40.68	10.77	35	47527	4081	42569692
Incorrect route of product administration	40.40	10.77	86	47476	24219	42549554
Pain	38.94	10.77	431	47131	244417	42329356
Overdose	38.18	10.77	224	47338	105040	42468733
SARS-CoV-2 test negative	37.86	10.77	24	47538	1751	42572022
Cardiogenic shock	37.73	10.77	106	47456	35534	42538239
Hypoxia	37.60	10.77	166	47396	69620	42504153
Respiratory paralysis	37.45	10.77	11	47551	111	42573662
Accident	37.27	10.77	41	47521	6462	42567311
Neurotoxicity	36.26	10.77	81	47481	23570	42550203
Trigemino-cardiac reflex	35.71	10.77	14	47548	357	42573416
Interstitial lung disease	35.22	10.77	22	47540	78440	42495333
Ear infection	34.80	10.77	56	47506	12748	42561025
Status epilepticus	34.24	10.77	62	47500	15516	42558257
Electrocardiogram QRS complex prolonged	33.87	10.77	37	47525	5786	42567987
Spinal cord infarction	33.86	10.77	16	47546	650	42573123
Infusion site erythema	32.20	10.77	29	47533	3593	42570180
Sinus tachycardia	31.96	10.77	71	47491	20582	42553191
Mydriasis	31.94	10.77	44	47518	8726	42565047
Haemodynamic instability	31.54	10.77	53	47509	12504	42561269
Cauda equina syndrome	30.74	10.77	17	47545	963	42572810
Tracheitis	29.81	10.77	17	47545	1022	42572751
Anaesthetic complication neurological	29.40	10.77	15	47547	721	42573052
Diarrhoea	29.10	10.77	352	47210	460497	42113276
Oculocardiac reflex	28.64	10.77	9	47553	116	42573657
Seizure	28.51	10.77	231	47331	120330	42453443
Apnoea	28.19	10.77	39	47523	7764	42566009
Proctalgia	27.98	10.77	37	47525	7056	42566717
Respiratory tract infection bacterial	26.92	10.77	20	47542	1889	42571884
Multiple organ dysfunction syndrome	26.90	10.77	193	47369	96842	42476931
Bronchospasm	26.71	10.77	50	47512	12835	42560938
Neuromuscular blockade	26.08	10.77	11	47551	340	42573433
Negative pressure pulmonary oedema	25.73	10.77	13	47549	612	42573161
Psoriasis	25.71	10.77	11	47551	48593	42525180
Blood phosphorus increased	25.21	10.77	48	47514	12477	42561296
Respiratory depression	24.96	10.77	61	47501	18807	42554966
Kounis syndrome	24.26	10.77	24	47538	3344	42570429
Decreased appetite	24.19	10.77	122	47440	193015	42380758
Respiratory arrest	23.93	10.77	78	47484	28346	42545427
Agranulocytosis	23.87	10.77	3	47559	30609	42543164
Respiratory tract infection	23.77	10.77	74	47488	26248	42547525
Weight decreased	23.48	10.77	136	47426	207812	42365961
Febrile neutropenia	23.42	10.77	313	47249	185390	42388383
Accidental overdose	23.18	10.77	77	47485	28253	42545520
Vasoplegia syndrome	23.09	10.77	21	47541	2634	42571139
Brain oedema	22.90	10.77	54	47508	16273	42557500
Hyperphosphataemia	22.76	10.77	47	47515	12957	42560816
Chemical burn	22.74	10.77	10	47552	343	42573430
Disease progression	22.74	10.77	83	47479	143573	42430200
Mental status changes	22.54	10.77	100	47462	42015	42531758
Retinal artery occlusion	22.23	10.77	19	47543	2196	42571577
Brain stem syndrome	21.94	10.77	12	47550	665	42573108
Product adhesion issue	21.84	10.77	17	47545	1722	42572051
Rheumatoid arthritis	21.82	10.77	10	47552	42430	42531343
Appendicolith	21.66	10.77	47	47515	13409	42560364
Corneal oedema	21.35	10.77	16	47546	1532	42572241
Neuralgia	21.25	10.77	70	47492	25577	42548196
Infusion site swelling	21.05	10.77	22	47540	3270	42570503
General physical health deterioration	21.02	10.77	92	47470	151154	42422619
Circulatory collapse	20.93	10.77	66	47496	23570	42550203
Prostate cancer	20.75	10.77	12	47550	44631	42529142
Diabetes insipidus	20.57	10.77	23	47539	3690	42570083
Type I hypersensitivity	20.56	10.77	18	47544	2148	42571625
Paraesthesia oral	20.47	10.77	27	47535	5136	42568637
Postoperative delirium	20.46	10.77	11	47551	589	42573184
Endophthalmitis	20.45	10.77	25	47537	4408	42569365
Respiratory tract infection viral	20.43	10.77	22	47540	3384	42570389
Intracranial hypotension	20.40	10.77	10	47552	441	42573332
Drug therapy	20.28	10.77	30	47532	6350	42567423
Myasthenia gravis	20.11	10.77	51	47511	16086	42557687
Myocardial infarction	20.05	10.77	71	47491	123938	42449835
Analgesic therapy	19.77	10.77	30	47532	6494	42567279
Lagophthalmos	19.72	10.77	7	47555	134	42573639
Embolia cutis medicamentosa	19.53	10.77	9	47553	345	42573428
Iron deficiency	19.38	10.77	40	47522	11021	42562752
Acute kidney injury	19.02	10.77	292	47270	367045	42206728
Aqueous fibrin	18.98	10.77	6	47556	79	42573694
Seizure like phenomena	18.94	10.77	13	47549	1084	42572689
Tubulointerstitial nephritis	18.60	10.77	6	47556	31542	42542231
Sleep disorder therapy	18.52	10.77	30	47532	6864	42566909
Enterobacter pneumonia	18.34	10.77	10	47552	551	42573222
Myoclonus	18.30	10.77	51	47511	17014	42556759
Suicide attempt	17.97	10.77	15	47547	46085	42527688
Reperfusion arrhythmia	17.85	10.77	6	47556	97	42573676
Macular ischaemia	17.69	10.77	7	47555	183	42573590
Myalgia	17.62	10.77	52	47510	96028	42477745
Anxiety	17.57	10.77	206	47356	118354	42455419
Spinal meningeal cyst	17.51	10.77	6	47556	103	42573670
Ventricular extrasystoles	17.40	10.77	43	47519	13347	42560426
Loss of consciousness	17.20	10.77	168	47394	92186	42481587
Thyrotoxic crisis	17.10	10.77	11	47551	823	42572950
Administration site pain	17.04	10.77	9	47553	465	42573308
Dermatitis contact	17.01	10.77	23	47539	4480	42569293
Tryptase increased	17.00	10.77	8	47554	322	42573451
Cardiotoxicity	16.83	10.77	30	47532	7415	42566358
Abdominal discomfort	16.68	10.77	37	47525	75218	42498555
Blindness	16.66	10.77	51	47511	17927	42555846
Completed suicide	16.42	10.77	54	47508	96411	42477362
Leukopenia	16.36	10.77	37	47525	74709	42499064
Pneumocystis jirovecii pneumonia	16.31	10.77	4	47558	25177	42548596
Hypoaesthesia oral	15.98	10.77	23	47539	4750	42569023
Laryngospasm	15.89	10.77	15	47547	1973	42571800
Hypoxic-ischaemic encephalopathy	15.87	10.77	24	47538	5178	42568595
Infusion site bruising	15.78	10.77	11	47551	941	42572832
Diabetic ketoacidosis	15.61	10.77	3	47559	22364	42551409
Catecholamine crisis	15.53	10.77	5	47557	70	42573703
Hypophosphataemia	15.45	10.77	55	47507	20890	42552883
Behaviour disorder	15.41	10.77	28	47534	7026	42566747
Therapy non-responder	15.28	10.77	107	47455	53252	42520521
Wrong product administered	15.26	10.77	26	47536	6200	42567573
Anal sphincter atony	14.98	10.77	6	47556	162	42573611
Vitreous disorder	14.91	10.77	6	47556	164	42573609
Post procedural complication	14.87	10.77	39	47523	12551	42561222
Weight increased	14.80	10.77	66	47496	107917	42465856
Hyperaesthesia	14.78	10.77	25	47537	5927	42567846
Hepatitis	14.72	10.77	6	47556	27294	42546479
Frequent bowel movements	14.67	10.77	3	47559	21404	42552369
Body temperature increased	14.63	10.77	53	47509	20305	42553468
Ventricular asystole	14.62	10.77	7	47555	293	42573480
Cardiac failure congestive	14.52	10.77	48	47514	85554	42488219
Haematochezia	14.42	10.77	27	47535	58409	42515364
Bacteroides infection	14.29	10.77	16	47546	2571	42571202
Swelling	13.97	10.77	107	47455	54778	42518995
Torsade de pointes	13.81	10.77	30	47532	8564	42565209
Electrocardiogram T wave amplitude increased	13.79	10.77	5	47557	102	42573671
Treatment noncompliance	13.79	10.77	13	47549	37659	42536114
Delayed recovery from anaesthesia	13.76	10.77	11	47551	1158	42572615
Phaeochromocytoma crisis	13.70	10.77	5	47557	104	42573669
Macroglossia	13.69	10.77	8	47554	504	42573269
Pulse absent	13.67	10.77	25	47537	6302	42567471
Myelosuppression	13.63	10.77	15	47547	40446	42533327
Vitreous floaters	13.60	10.77	20	47542	4210	42569563
Asthenia	13.58	10.77	226	47336	280567	42293206
Cholangitis infective	13.56	10.77	7	47555	345	42573428
Melaena	13.46	10.77	14	47548	38732	42535041
Appendicitis	13.43	10.77	52	47510	20561	42553212
Malaise	13.35	10.77	162	47400	211994	42361779
Malignant neoplasm progression	13.26	10.77	69	47493	108331	42465442
Oxygen saturation decreased	13.20	10.77	120	47442	64567	42509206
Myokymia	13.15	10.77	5	47557	117	42573656
Procedural hypotension	13.02	10.77	10	47552	993	42572780
Pancreatitis acute	12.98	10.77	11	47551	33553	42540220
Postictal state	12.87	10.77	10	47552	1010	42572763
Hepatotoxicity	12.83	10.77	6	47556	25161	42548612
Ophthalmoplegia	12.83	10.77	14	47548	2186	42571587
Asthma	12.72	10.77	32	47530	62282	42511491
Haemoglobin decreased	12.71	10.77	91	47471	132380	42441393
Drug hypersensitivity	12.71	10.77	168	47394	99221	42474552
Procedural pain	12.70	10.77	23	47539	5756	42568017
Therapeutic product effect incomplete	12.57	10.77	39	47523	70900	42502873
Shock	12.57	10.77	65	47497	29056	42544717
Ventricular arrhythmia	12.56	10.77	24	47538	6255	42567518
Dyspnoea exertional	12.52	10.77	23	47539	50125	42523648
Encephalomalacia	12.52	10.77	10	47552	1051	42572722
Oesophageal obstruction	12.49	10.77	8	47554	594	42573179
Blood uric acid increased	12.49	10.77	42	47520	15505	42558268
Respiratory acidosis	12.42	10.77	24	47538	6307	42567466
Blood pH decreased	12.33	10.77	14	47548	2284	42571489
Blood pressure systolic increased	12.33	10.77	8	47554	27960	42545813
Loss of personal independence in daily activities	12.30	10.77	23	47539	49793	42523980
Dyspepsia	12.18	10.77	17	47545	41335	42532438
Mean arterial pressure increased	12.17	10.77	4	47558	60	42573713
Fatigue	12.16	10.77	382	47180	435259	42138514
Brain hypoxia	12.08	10.77	8	47554	629	42573144
Drug-induced liver injury	12.02	10.77	15	47547	38258	42535515
Pulseless electrical activity	11.94	10.77	28	47534	8409	42565364
Pancreatic enzymes increased	11.88	10.77	9	47553	876	42572897
Haemorrhoids	11.85	10.77	44	47518	17053	42556720
Retinal vasculitis	11.79	10.77	8	47554	655	42573118
Upper respiratory tract infection	11.74	10.77	84	47478	42089	42531684
Arthritis	11.70	10.77	18	47544	42047	42531726
Total lung capacity decreased	11.65	10.77	17	47545	3553	42570220
Infusion site pruritus	11.64	10.77	10	47552	1163	42572610
Kidney congestion	11.62	10.77	7	47555	466	42573307
Lung opacity	11.29	10.77	22	47540	5815	42567958
Pulmonary fibrosis	11.27	10.77	8	47554	26673	42547100
Anaemia	11.24	10.77	233	47329	280045	42293728
Open globe injury	11.16	10.77	4	47558	79	42573694
Post herpetic neuralgia	11.12	10.77	10	47552	1236	42572537
Myotonic dystrophy	11.07	10.77	5	47557	183	42573590
Disability	11.04	10.77	22	47540	5911	42567862
Illness	11.01	10.77	56	47506	24874	42548899
Anaesthetic complication pulmonary	10.97	10.77	4	47558	83	42573690
Skin hyperpigmentation	10.97	10.77	18	47544	4163	42569610
Sinus bradycardia	10.95	10.77	39	47523	14814	42558959
Product contamination microbial	10.90	10.77	8	47554	742	42573031
Hypopyon	10.83	10.77	7	47555	528	42573245
Chills	10.80	10.77	156	47406	93910	42479863

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Local anaesthetic systemic toxicity	1345.44	9.56	402	105125	5135	110478637
Anaphylactic reaction	509.42	9.56	586	104941	113714	110370058
Anaphylactic shock	498.64	9.56	405	105122	51141	110432631
Cardiac arrest	407.55	9.56	698	104829	196055	110287717
Toxic anterior segment syndrome	321.95	9.56	122	105405	3332	110480440
Maternal exposure during delivery	286.31	9.56	113	105414	3452	110480320
Methaemoglobinaemia	285.11	9.56	150	105377	9018	110474754
Nasal oedema	253.62	9.56	126	105401	6713	110477059
Hypotension	240.42	9.56	1063	104464	522786	109960986
Anaesthetic complication	227.03	9.56	96	105431	3510	110480262
Synovitis	212.86	9.56	12	105515	274080	110209692
Generalised tonic-clonic seizure	190.94	9.56	248	105279	54432	110429340
Toxicity to various agents	179.46	9.56	919	104608	479636	110004136
Hand deformity	174.61	9.56	8	105519	218498	110265274
Bradycardia	172.00	9.56	426	105101	155091	110328681
Kounis syndrome	167.54	9.56	91	105436	5834	110477938
Systemic lupus erythematosus	165.73	9.56	23	105504	254315	110229457
Respiratory tract infection	158.61	9.56	262	105265	71355	110412417
Inspiratory capacity decreased	156.46	9.56	67	105460	2528	110481244
Joint swelling	155.77	9.56	117	105410	442728	110041044
Helicobacter infection	154.61	9.56	4	105523	181873	110301899
Pemphigus	153.36	9.56	14	105513	214556	110269216
Pericarditis	149.60	9.56	17	105510	219097	110264675
Anti-cyclic citrullinated peptide antibody positive	147.60	9.56	6	105521	181978	110301794
Fear	146.02	9.56	143	105384	23050	110460722
Hepatic enzyme increased	142.30	9.56	64	105463	320828	110162944
Duodenal ulcer perforation	140.38	9.56	7	105520	177693	110306079
Ventricular tachycardia	138.75	9.56	203	105324	49806	110433966
Glossodynia	137.94	9.56	23	105504	221981	110261791
Ventricular fibrillation	137.46	9.56	183	105344	41130	110442642
Contraindicated product administered	137.09	9.56	34	105493	248233	110235539
Renal injury	130.35	9.56	122	105405	18591	110465181
Arthropathy	126.45	9.56	58	105469	287464	110196308
Drug ineffective for unapproved indication	123.63	9.56	291	105236	102547	110381225
Seizure	121.70	9.56	475	105052	220710	110263062
Unresponsive to stimuli	121.10	9.56	218	105309	63572	110420200
Emotional distress	118.60	9.56	178	105349	44669	110439103
General physical health deterioration	118.23	9.56	139	105388	425156	110058616
Anhedonia	110.19	9.56	102	105425	15326	110468446
Folliculitis	107.24	9.56	16	105511	167637	110316135
Stress cardiomyopathy	106.18	9.56	101	105426	15705	110468067
Anaesthetic complication neurological	105.43	9.56	39	105488	994	110482778
Pulseless electrical activity	103.03	9.56	102	105425	16655	110467117
Mobility decreased	101.15	9.56	50	105477	237372	110246400
Abdominal discomfort	100.85	9.56	137	105390	393721	110090051
Unevaluable event	99.41	9.56	192	105335	59035	110424737
Wound	98.93	9.56	50	105477	234387	110249385
Type 2 diabetes mellitus	98.36	9.56	24	105503	177208	110306564
Muscle injury	95.91	9.56	11	105516	140796	110342976
Rheumatoid factor positive	95.65	9.56	8	105519	131632	110352140
Psoriatic arthropathy	94.07	9.56	35	105492	196726	110287046
Rheumatic fever	90.31	9.56	7	105520	122572	110361200
Status epilepticus	90.25	9.56	130	105397	31441	110452331
Tachycardia	84.09	9.56	433	105094	226212	110257560
Rheumatoid arthritis	83.14	9.56	98	105429	299515	110184257
Neurotoxicity	82.36	9.56	146	105381	42061	110441711
Procedural hypotension	80.78	9.56	42	105485	2463	110481309
Liver injury	80.34	9.56	22	105505	150391	110333381
Apnoea	80.14	9.56	81	105446	13558	110470214
Mental status changes	79.38	9.56	204	105323	75918	110407854
Therapeutic product effect decreased	79.04	9.56	70	105457	244246	110239526
Drug ineffective	78.59	9.56	1950	103577	1518590	108965182
Insurance issue	77.42	9.56	71	105456	10541	110473231
Facet joint syndrome	75.87	9.56	4	105523	96824	110386948
C-reactive protein abnormal	75.08	9.56	16	105511	129679	110354093
Corneal oedema	74.13	9.56	43	105484	3130	110480642
Alopecia	73.68	9.56	148	105379	364605	110119167
Drug intolerance	73.03	9.56	176	105351	406336	110077436
Cardiogenic shock	73.01	9.56	166	105361	57172	110426600
Impaired healing	71.66	9.56	50	105477	196667	110287105
Irritable bowel syndrome	70.82	9.56	34	105493	164181	110319591
Sinus tachycardia	68.35	9.56	139	105388	44354	110439418
Product adhesion issue	68.28	9.56	40	105487	2966	110480806
Incorrect route of product administration	68.16	9.56	173	105354	63888	110419884
Pulse absent	68.07	9.56	68	105459	11224	110472548
Bursitis	67.54	9.56	20	105507	129898	110353874
Arthralgia	67.13	9.56	452	105075	779180	109704592
Sleep disorder due to general medical condition, insomnia type	65.48	9.56	11	105516	105632	110378140
Lip dry	65.28	9.56	9	105518	100074	110383698
Bronchospasm	64.75	9.56	109	105418	30130	110453642
Stress	63.48	9.56	233	105294	105115	110378657
Hypercholesterolaemia	62.10	9.56	7	105520	90830	110392942
Inflammation	61.74	9.56	56	105471	193182	110290590
Obesity	61.63	9.56	16	105511	113335	110370437
Cauda equina syndrome	61.13	9.56	33	105494	2089	110481683
Hyperthermia malignant	61.11	9.56	41	105486	3859	110479913
Musculoskeletal stiffness	60.47	9.56	109	105418	279713	110204059
Hypoxia	60.06	9.56	264	105263	129251	110354521
Ill-defined disorder	59.64	9.56	38	105489	156815	110326957
Lagophthalmos	59.43	9.56	22	105505	562	110483210
Completed suicide	59.32	9.56	87	105440	242294	110241478
Peripheral venous disease	58.73	9.56	6	105521	84111	110399661
Endophthalmitis	58.22	9.56	54	105473	8133	110475639
Dermatitis contact	56.21	9.56	68	105459	13885	110469887
Infusion site pain	56.16	9.56	76	105451	17343	110466429
Swollen joint count increased	55.82	9.56	7	105520	83654	110400118
Sulphaemoglobinaemia	55.39	9.56	21	105506	574	110483198
Embolia cutis medicamentosa	55.22	9.56	24	105503	939	110482833
Multiple organ dysfunction syndrome	54.96	9.56	288	105239	151422	110332350
Infusion related reaction	54.48	9.56	184	105343	380978	110102794
Blister	54.30	9.56	83	105444	227293	110256479
Extradural abscess	54.09	9.56	30	105497	2004	110481768
Myelosuppression	53.87	9.56	12	105515	94328	110389444
Haemodynamic instability	53.73	9.56	86	105441	22802	110460970
Osteoarthritis	53.63	9.56	57	105470	182566	110301206
Gait inability	51.90	9.56	33	105494	136343	110347429
Respiratory depression	51.58	9.56	102	105425	31899	110451873
Electrocardiogram ST segment elevation	51.27	9.56	53	105474	9107	110474665
Infusion site bruising	51.18	9.56	36	105491	3658	110480114
Type I hypersensitivity	51.03	9.56	45	105482	6348	110477424
Fibromyalgia	50.57	9.56	53	105474	170856	110312916
Anterior chamber cell	49.77	9.56	24	105503	1197	110482575
Infusion site swelling	49.70	9.56	54	105473	9823	110473949
Abdominal pain upper	49.57	9.56	169	105358	348942	110134830
Hypopyon	48.90	9.56	25	105502	1415	110482357
Trigemino-cardiac reflex	48.87	9.56	18	105509	453	110483319
Premature delivery	47.41	9.56	96	105431	30536	110453236
Extradural haematoma	47.07	9.56	33	105494	3336	110480436
Lower respiratory tract infection	46.25	9.56	102	105425	243004	110240768
Infusion site erythema	46.10	9.56	57	105470	11902	110471870
Anal inflammation	45.87	9.56	29	105498	2467	110481305
Systemic toxicity	45.72	9.56	16	105511	346	110483426
Overdose	45.59	9.56	380	105147	233414	110250358
Electrocardiogram QRS complex prolonged	45.35	9.56	59	105468	12962	110470810
Illness	44.76	9.56	176	105351	81995	110401777
Infusion site extravasation	44.13	9.56	55	105472	11579	110472193
C-reactive protein increased	43.48	9.56	89	105438	217830	110265942
Spinal cord infarction	43.01	9.56	21	105506	1077	110482695
Hypoaesthesia oral	42.85	9.56	66	105461	16936	110466836
Pulmonary fibrosis	42.67	9.56	22	105505	102020	110381752
Retinal artery occlusion	42.36	9.56	34	105493	4215	110479557
Proctalgia	41.58	9.56	57	105470	13165	110470607
Circulatory collapse	41.53	9.56	112	105415	42881	110440891
Infusion site pruritus	41.48	9.56	36	105491	4972	110478800
Respiratory paralysis	41.45	9.56	12	105515	136	110483636
Aqueous fibrin	41.20	9.56	13	105514	201	110483571
Febrile neutropenia	40.76	9.56	472	105055	316295	110167477
Joint range of motion decreased	40.49	9.56	34	105493	121798	110361974
Paraplegia	40.47	9.56	39	105488	6161	110477611
Hepatitis	39.82	9.56	18	105509	90036	110393736
Brain oedema	39.55	9.56	90	105437	31008	110452764
Vitritis	39.44	9.56	27	105500	2626	110481146
Liver disorder	38.92	9.56	47	105480	142196	110341576
Ophthalmoplegia	38.82	9.56	30	105497	3520	110480252
Mydriasis	38.61	9.56	73	105454	22084	110461688
Nail disorder	38.28	9.56	5	105522	57930	110425842
Loss of consciousness	38.23	9.56	319	105208	195987	110287785
Retinal vasculitis	38.14	9.56	24	105503	2025	110481747
Paraesthesia oral	37.99	9.56	93	105434	33578	110450194
Neuromuscular blockade	37.70	9.56	17	105510	727	110483045
Psoriasis	37.53	9.56	47	105480	139946	110343826
Staphylococcal infection	37.44	9.56	149	105378	69795	110413977
Deep vein thrombosis postoperative	37.13	9.56	6	105521	59285	110424487
Grip strength decreased	37.08	9.56	15	105512	80159	110403613
SARS-CoV-2 test negative	37.05	9.56	24	105503	2129	110481643
Haemorrhoids	36.56	9.56	95	105432	35577	110448195
Fear of eating	36.41	9.56	15	105512	513	110483259
Peripheral nerve injury	36.31	9.56	19	105508	1129	110482643
Adulterated product	36.20	9.56	19	105508	1136	110482636
Lung disorder	35.52	9.56	74	105453	179973	110303799
Adverse event	35.38	9.56	31	105496	108778	110374994
Asthenia	35.18	9.56	455	105072	688544	109795228
Vasoplegia syndrome	35.10	9.56	34	105493	5405	110478367
Post procedural complication	34.85	9.56	78	105449	26580	110457192
Urinary tract infection	34.61	9.56	469	105058	325813	110157959
Respiratory tract infection bacterial	34.54	9.56	24	105503	2392	110481380
Paralysis	34.43	9.56	57	105470	15543	110468229
Respiratory failure	34.31	9.56	335	105192	214997	110268775
Meningitis chemical	34.23	9.56	13	105514	357	110483415
Interstitial lung disease	34.09	9.56	50	105477	139284	110344488
Accidental overdose	34.08	9.56	118	105409	51716	110432056
Drug-induced liver injury	33.57	9.56	39	105488	120028	110363744
Weight increased	33.24	9.56	249	105278	419395	110064377
Vascular malformation	33.18	9.56	16	105511	798	110482974
Seasonal allergy	33.17	9.56	64	105463	19658	110464114
Gastrointestinal disorder	33.07	9.56	119	105408	241833	110241939
Pulmonary oedema	33.01	9.56	186	105341	100473	110383299
Arthritis	32.96	9.56	69	105458	167517	110316255
Appendicolith	32.69	9.56	53	105474	14202	110469570
Condition aggravated	32.64	9.56	499	105028	734337	109749435
Cardiotoxicity	32.42	9.56	58	105469	16823	110466949
Prescribed underdose	32.15	9.56	11	105516	65163	110418609
Infusion site haemorrhage	32.06	9.56	30	105497	4568	110479204
Anxiety	31.82	9.56	484	105043	344594	110139178
Spinal epidural haemorrhage	31.72	9.56	12	105515	326	110483446
Delayed recovery from anaesthesia	31.65	9.56	22	105505	2193	110481579
Tracheitis	31.64	9.56	20	105507	1701	110482071
Spinal epidural haematoma	31.60	9.56	20	105507	1705	110482067
Paranasal cyst	31.59	9.56	16	105511	888	110482884
Corneal epithelium defect	31.46	9.56	16	105511	896	110482876
Musculoskeletal pain	31.45	9.56	81	105446	182942	110300830
COVID-19	31.44	9.56	365	105162	244695	110239077
Postoperative delirium	31.41	9.56	16	105511	899	110482873
Chemical burn	31.39	9.56	15	105512	733	110483039
Blepharospasm	31.27	9.56	7	105520	54844	110428928
Blood phosphorus increased	31.20	9.56	56	105471	16284	110467488
Tryptase increased	30.95	9.56	16	105511	927	110482845
Sepsis	30.91	9.56	461	105066	326885	110156887
Nystagmus	30.67	9.56	46	105481	11531	110472241
Ventricular extrasystoles	30.44	9.56	67	105460	22574	110461198
Lower limb fracture	30.40	9.56	17	105510	75331	110408441
Swelling	30.38	9.56	203	105324	350838	110132934
Coeliac disease	30.36	9.56	3	105524	43184	110440588
Visual acuity reduced	30.26	9.56	83	105444	32090	110451682
Respiratory arrest	30.25	9.56	123	105404	58176	110425596
Analgesic therapy	30.16	9.56	36	105491	7248	110476524
Drug therapy	30.14	9.56	36	105491	7255	110476517
Stridor	30.08	9.56	35	105492	6860	110476912
Anal sphincter atony	30.07	9.56	13	105514	502	110483270
Punctate keratitis	29.96	9.56	17	105510	1187	110482585
Wrong product administered	29.68	9.56	44	105483	10916	110472856
Oculocardiac reflex	29.62	9.56	9	105518	122	110483650
Sleep disorder therapy	29.43	9.56	36	105491	7435	110476337
Blood cholesterol increased	29.34	9.56	85	105442	184700	110299072
Myasthenia gravis	29.31	9.56	64	105463	21447	110462325
Underdose	29.21	9.56	12	105515	63542	110420230
Hypersensitivity	29.09	9.56	246	105281	403752	110080020
Neuralgia	29.00	9.56	107	105420	48371	110435401
Pain	28.90	9.56	1149	104378	953806	109529966
Peripheral swelling	28.65	9.56	247	105280	403787	110079985
Hyperphosphataemia	28.58	9.56	54	105473	16327	110467445
Diarrhoea	28.54	9.56	849	104678	1138656	109345116
Oedema	28.40	9.56	316	105211	209660	110274112
Night sweats	28.21	9.56	53	105474	133930	110349842
Purtscher retinopathy	28.20	9.56	10	105517	225	110483547
Onychomadesis	27.76	9.56	5	105522	45658	110438114
Loss of personal independence in daily activities	27.66	9.56	64	105463	149956	110333816
Incorrect drug administration rate	27.51	9.56	30	105497	5478	110478294
Wound infection	27.33	9.56	31	105496	96434	110387338
Red blood cell sedimentation rate increased	27.08	9.56	21	105506	78281	110405491
Accident	26.88	9.56	42	105485	10910	110472862
Blood pressure decreased	26.81	9.56	195	105332	114896	110368876
Neuromuscular block prolonged	26.77	9.56	16	105511	1231	110482541
Infusion site mass	26.68	9.56	18	105509	1710	110482062
Diabetes insipidus	26.44	9.56	32	105495	6538	110477234
Upper respiratory tract infection	26.41	9.56	215	105312	131113	110352659
Suicide attempt	26.39	9.56	36	105491	103358	110380414
Negative pressure pulmonary oedema	26.28	9.56	13	105514	686	110483086
Decreased appetite	26.23	9.56	309	105218	475537	110008235
Procedural pain	26.08	9.56	84	105443	35481	110448291
Epidural haemorrhage	26.01	9.56	11	105516	402	110483370
Upper airway obstruction	25.99	9.56	18	105509	1784	110481988
Lupus-like syndrome	25.83	9.56	4	105523	40788	110442984
Sinusitis	25.77	9.56	412	105115	296276	110187496
Platelet aggregation inhibition	25.44	9.56	9	105518	201	110483571
Product use issue	25.13	9.56	184	105343	311511	110172261
Prescribed overdose	24.97	9.56	28	105499	87553	110396219
Therapy partial responder	24.92	9.56	85	105442	36976	110446796
Multiple allergies	24.67	9.56	43	105484	12220	110471552
Medical device site cellulitis	24.61	9.56	9	105518	222	110483550
Procedural complication	24.59	9.56	35	105492	8370	110475402
Bacterial infection	24.58	9.56	98	105429	45938	110437834
Infusion site urticaria	24.55	9.56	15	105512	1201	110482571
Trigeminal palsy	24.54	9.56	7	105520	75	110483697
Respiratory distress	24.42	9.56	130	105397	68744	110415028
Bursitis infective	24.29	9.56	16	105511	1460	110482312
Pneumocephalus	24.04	9.56	11	105516	487	110483285
Foetal heart rate abnormal	23.74	9.56	12	105515	663	110483109
Drug reaction with eosinophilia and systemic symptoms	23.67	9.56	26	105501	82069	110401703
Body tinea	23.41	9.56	18	105509	2097	110481675
Hip arthroplasty	23.38	9.56	12	105515	55801	110427971
Parophthalmia	23.26	9.56	11	105516	525	110483247
Blindness	23.24	9.56	82	105445	36277	110447495
Brain stem syndrome	23.22	9.56	15	105512	1324	110482448
Epidural analgesia	23.21	9.56	8	105519	165	110483607
Septic arthritis staphylococcal	23.17	9.56	13	105514	888	110482884
Otitis media	23.17	9.56	32	105495	7444	110476328
Knee arthroplasty	23.00	9.56	17	105510	64931	110418841
Spinal cord compression	22.91	9.56	32	105495	7520	110476252
Procedure aborted	22.86	9.56	8	105519	173	110483599
Epilepsy	22.57	9.56	38	105489	100171	110383601
Inadequate analgesia	22.53	9.56	26	105501	5051	110478721
Cyanosis	22.50	9.56	71	105456	29670	110454102
Shock	22.42	9.56	106	105421	53482	110430290
Cardio-respiratory arrest	22.41	9.56	188	105339	115648	110368124
Hepatic cirrhosis	22.31	9.56	19	105508	67607	110416165
Hypophosphataemia	22.22	9.56	76	105451	33106	110450666
Eyelid ptosis	22.11	9.56	43	105484	13284	110470488
Medical device site abscess	21.70	9.56	8	105519	202	110483570
Spinal anaesthesia	21.63	9.56	7	105520	118	110483654
Product dose omission issue	21.60	9.56	429	105098	321353	110162419
Rash	21.43	9.56	608	104919	820356	109663416
Hyperaesthesia	21.43	9.56	45	105482	14682	110469090
Airway peak pressure increased	21.33	9.56	11	105516	634	110483138
Mean arterial pressure decreased	21.08	9.56	10	105517	481	110483291
Nerve root injury	20.89	9.56	6	105521	66	110483706
Confusional state	20.86	9.56	318	105209	468362	110015410
Retinitis	20.86	9.56	3	105524	32324	110451448
Product contamination microbial	20.83	9.56	13	105514	1081	110482691
Myoclonus	20.73	9.56	74	105453	32924	110450848
Hepatotoxicity	20.69	9.56	18	105509	63382	110420390
Carbon dioxide decreased	20.64	9.56	24	105503	4700	110479072
Macular ischaemia	20.62	9.56	8	105519	233	110483539
Pupillary reflex impaired	20.29	9.56	22	105505	3993	110479779
Sleep disorder	20.27	9.56	109	105418	198535	110285237
Nasopharyngitis	20.24	9.56	260	105267	394101	110089671
Stomatitis	20.14	9.56	163	105364	270079	110213693
Infusion site discharge	20.12	9.56	16	105511	1957	110481815
Mastoiditis	20.09	9.56	18	105509	2593	110481179
Torsade de pointes	19.97	9.56	57	105470	22543	110461229
Back pain	19.92	9.56	479	105048	370517	110113255
Pneumocystis jirovecii pneumonia	19.75	9.56	8	105519	42727	110441045
Disease progression	19.69	9.56	144	105383	243890	110239882
Drug level increased	19.68	9.56	94	105433	47625	110436147
Atonic urinary bladder	19.68	9.56	7	105520	159	110483613
Agranulocytosis	19.59	9.56	18	105509	61742	110422030
Tubulointerstitial nephritis	19.49	9.56	14	105513	54270	110429502
Foot deformity	19.47	9.56	11	105516	48469	110435303
Skin infection	19.15	9.56	56	105471	22453	110461319
Cholestasis	19.09	9.56	20	105507	64498	110419274
Miosis	19.00	9.56	55	105472	21928	110461844
Chills	19.00	9.56	271	105256	190309	110293463
Tachypnoea	18.78	9.56	81	105446	39314	110444458
Gastroenteritis viral	18.74	9.56	69	105458	31157	110452615
Iron deficiency	18.72	9.56	49	105478	18427	110465345
Intracranial hypotension	18.60	9.56	10	105517	628	110483144
Sinus bradycardia	18.42	9.56	66	105461	29417	110454355
Behaviour disorder	18.34	9.56	33	105494	9614	110474158
Bundle branch block left	18.31	9.56	39	105488	12849	110470923
Intentional product use issue	18.26	9.56	150	105377	247756	110236016
Vaginal abscess	18.03	9.56	9	105518	484	110483288
Appendicitis	18.02	9.56	64	105463	28400	110455372
Respiratory tract infection viral	17.97	9.56	25	105502	5853	110477919
Product preparation error	17.92	9.56	35	105492	10844	110472928
Leukopenia	17.89	9.56	77	105450	148714	110335058
Corneal abrasion	17.84	9.56	13	105514	1396	110482376
Insomnia	17.68	9.56	240	105287	360350	110123422
Tenderness	17.63	9.56	65	105462	29372	110454400
Tremor	17.61	9.56	281	105246	201951	110281821
Pancreatitis acute	17.48	9.56	19	105508	60255	110423517
Taste disorder	17.47	9.56	22	105505	65365	110418407
Vocal cord dysfunction	17.36	9.56	11	105516	939	110482833
Intentional self-injury	17.31	9.56	7	105520	37422	110446350
Restlessness	17.17	9.56	102	105425	56157	110427615
Seizure like phenomena	17.16	9.56	16	105511	2425	110481347
Erythema	17.09	9.56	381	105146	291066	110192706
Fatigue	17.07	9.56	968	104559	1214990	109268782
Nail bed tenderness	17.03	9.56	8	105519	376	110483396
Anaphylactoid shock	16.99	9.56	11	105516	975	110482797
Orthostatic hypotension	16.97	9.56	23	105504	66226	110417546
Spinal meningeal cyst	16.96	9.56	6	105521	134	110483638
Diplopia	16.90	9.56	82	105445	41812	110441960
Anterior chamber fibrin	16.89	9.56	7	105520	243	110483529
Renal failure	16.89	9.56	307	105220	226267	110257505
Anal skin tags	16.88	9.56	9	105518	556	110483216
Heparin-induced thrombocytopenia	16.73	9.56	35	105492	11389	110472383
Onychomycosis	16.57	9.56	8	105519	38523	110445249
Phrenic nerve paralysis	16.55	9.56	9	105518	578	110483194
Bacteroides infection	16.54	9.56	17	105510	2902	110480870
Hypoxic-ischaemic encephalopathy	16.48	9.56	30	105497	8817	110474955
Respiratory acidosis	16.47	9.56	39	105488	13787	110469985
Quadriplegia	16.44	9.56	20	105507	4107	110479665
Economic problem	16.43	9.56	20	105507	4111	110479661
Oxygen saturation decreased	16.36	9.56	225	105302	156757	110327015
Enterobacter pneumonia	16.30	9.56	9	105518	596	110483176
Drug hypersensitivity	16.25	9.56	557	104970	453533	110030239
Diabetic ketoacidosis	16.24	9.56	10	105517	42048	110441724
Thrombocytopenia	16.11	9.56	235	105292	348650	110135122
Injection site joint infection	16.05	9.56	5	105522	74	110483698
Back injury	16.03	9.56	13	105514	47386	110436386
Laryngospasm	16.02	9.56	21	105506	4647	110479125
Spinal cord injury	15.92	9.56	13	105514	1652	110482120
Vitamin D increased	15.90	9.56	10	105517	843	110482929
Therapeutic product effect incomplete	15.77	9.56	137	105390	223668	110260104
Anaesthetic complication pulmonary	15.56	9.56	6	105521	172	110483600
Autoimmune disorder	15.53	9.56	24	105503	65459	110418313
Streptococcal infection	15.53	9.56	33	105494	10857	110472915
Infection susceptibility increased	15.43	9.56	20	105507	4378	110479394
Spinal cord oedema	15.37	9.56	8	105519	470	110483302
Reperfusion arrhythmia	15.36	9.56	7	105520	307	110483465
Airway complication of anaesthesia	15.27	9.56	9	105518	675	110483097
Sensory loss	15.12	9.56	50	105477	21407	110462365
Exostosis	15.05	9.56	13	105514	45943	110437829
Hypercapnia	14.98	9.56	33	105494	11126	110472646
Ventricular arrhythmia	14.89	9.56	31	105496	10056	110473716
Encephalopathy	14.86	9.56	130	105397	80925	110402847
Implant site bruising	14.85	9.56	7	105520	332	110483440
Catecholamine crisis	14.84	9.56	5	105522	96	110483676
Pruritus	14.82	9.56	432	105095	581128	109902644
Infusion site discomfort	14.80	9.56	13	105514	1824	110481948
Aortic stenosis	14.66	9.56	36	105491	13023	110470749
Kidney congestion	14.61	9.56	8	105519	521	110483251
Anal ulcer	14.57	9.56	13	105514	1863	110481909
Ventricular tachyarrhythmia	14.55	9.56	8	105519	525	110483247
Application site alopecia	14.55	9.56	4	105523	37	110483735
Cholestasis of pregnancy	14.51	9.56	11	105516	1254	110482518
Familial periodic paralysis	14.46	9.56	7	105520	352	110483420
Eyelid contusion	14.42	9.56	5	105522	105	110483667
Left ventricle outflow tract obstruction	14.41	9.56	8	105519	535	110483237
Hypoaesthesia	14.38	9.56	212	105315	314011	110169761
Total lung capacity decreased	14.38	9.56	25	105502	7089	110476683
Agitation	14.31	9.56	168	105359	112883	110370889
Glucose tolerance impaired	14.25	9.56	30	105497	9807	110473965
Eclampsia	14.23	9.56	7	105520	365	110483407
Vascular stenosis	14.20	9.56	9	105518	769	110483003
Chorioretinopathy	14.16	9.56	14	105513	2281	110481491
Memory impairment	14.12	9.56	120	105407	196824	110286948
Retrograde amnesia	14.10	9.56	9	105518	778	110482994
Iron binding capacity total decreased	14.09	9.56	8	105519	559	110483213
Product distribution issue	14.07	9.56	19	105508	4327	110479445
Repetitive strain injury	14.02	9.56	6	105521	226	110483546
Disseminated intravascular coagulation	14.00	9.56	77	105450	41209	110442563
Infusion site rash	13.92	9.56	14	105513	2329	110481443
Vitreous disorder	13.90	9.56	7	105520	384	110483388
Vision blurred	13.88	9.56	186	105341	128836	110354936
Liver function test abnormal	13.88	9.56	28	105499	68922	110414850
Ear infection	13.87	9.56	105	105422	62627	110421145
Apnoeic attack	13.85	9.56	9	105518	803	110482969
Infusion site streaking	13.80	9.56	8	105519	582	110483190
Ventricular hypokinesia	13.76	9.56	32	105495	11182	110472590
Heliotrope rash	13.73	9.56	6	105521	238	110483534
Spinal cord ischaemia	13.73	9.56	6	105521	238	110483534
Blood pressure fluctuation	13.73	9.56	32	105495	74792	110408980
Monoplegia	13.72	9.56	20	105507	4889	110478883
Nail bed inflammation	13.69	9.56	13	105514	2017	110481755
Product administered at inappropriate site	13.68	9.56	21	105506	5372	110478400
Normal newborn	13.66	9.56	49	105478	21847	110461925
Administration site pain	13.66	9.56	9	105518	822	110482950
Bronchitis	13.59	9.56	218	105309	156814	110326958
Procedural haemorrhage	13.58	9.56	21	105506	5406	110478366
C-reactive protein	13.50	9.56	6	105521	30325	110453447
Axillary nerve injury	13.46	9.56	4	105523	50	110483722
Abortion spontaneous	13.45	9.56	8	105519	34274	110449498
Atrioventricular block complete	13.45	9.56	46	105481	20036	110463736
Depressed level of consciousness	13.41	9.56	165	105362	112113	110371659
Application site pain	13.37	9.56	21	105506	5478	110478294
Blood uric acid increased	13.28	9.56	48	105479	21481	110462291
Ventricular asystole	13.28	9.56	7	105520	422	110483350
Air embolism	13.19	9.56	8	105519	632	110483140
Body dysmorphic disorder	13.19	9.56	7	105520	428	110483344
Irregular breathing	13.18	9.56	8	105519	633	110483139
Discomfort	13.17	9.56	136	105391	214571	110269201
Harlequin syndrome	13.12	9.56	6	105521	265	110483507
Infection	13.12	9.56	255	105272	361945	110121827
Acute kidney injury	13.11	9.56	485	105042	634945	109848827
Lung opacity	12.95	9.56	32	105495	11620	110472152
Viral infection	12.93	9.56	91	105436	53048	110430724
Sciatica	12.91	9.56	45	105482	92354	110391418
Encephalomalacia	12.85	9.56	11	105516	1491	110482281
Glossoptosis	12.84	9.56	6	105521	279	110483493
Cystic fibrosis	12.82	9.56	19	105508	4712	110479060
Allergy to immunoglobulin therapy	12.78	9.56	5	105522	149	110483623
Pancytopenia	12.77	9.56	133	105394	209480	110274292
Myokymia	12.72	9.56	5	105522	151	110483621
Colitis ulcerative	12.71	9.56	35	105492	77328	110406444
Accelerated idioventricular rhythm	12.70	9.56	6	105521	286	110483486
Oxidative stress	12.67	9.56	4	105523	62	110483710
Laboratory test abnormal	12.66	9.56	14	105513	44065	110439707
Nasal mucosal disorder	12.58	9.56	12	105515	1871	110481901
Spinal stroke	12.55	9.56	4	105523	64	110483708
Serotonin syndrome	12.52	9.56	98	105429	59055	110424717
Conjunctival oedema	12.51	9.56	11	105516	1545	110482227
Kidney infection	12.49	9.56	53	105474	25546	110458226
Exophthalmos	12.45	9.56	13	105514	2260	110481512
Premature baby	12.45	9.56	19	105508	4836	110478936
Cough	12.44	9.56	549	104978	461092	110022680
Pseudomonas infection	12.32	9.56	56	105471	27797	110455975
Gastrooesophageal reflux disease	12.31	9.56	111	105416	179865	110303907
Femoral nerve injury	12.27	9.56	4	105523	69	110483703
Depression	12.24	9.56	221	105306	317114	110166658
Disease recurrence	11.97	9.56	25	105502	60759	110423013
Acute respiratory failure	11.93	9.56	117	105410	75143	110408629
Uveitis	11.92	9.56	3	105524	21707	110462065
Prostate cancer	11.90	9.56	11	105516	37630	110446142
Blood pressure systolic increased	11.88	9.56	40	105487	82951	110400821
Infective pulmonary exacerbation of cystic fibrosis	11.86	9.56	36	105491	14735	110469037
Lethargy	11.82	9.56	139	105388	93437	110390335
Lung neoplasm malignant	11.80	9.56	9	105518	33833	110449939
Orbital infection	11.79	9.56	5	105522	184	110483588
Allergy to arthropod sting	11.73	9.56	6	105521	340	110483432
Opisthotonus	11.69	9.56	8	105519	778	110482994
Transferrin decreased	11.68	9.56	7	105520	541	110483231
Postictal state	11.66	9.56	13	105514	2433	110481339
Brain herniation	11.66	9.56	26	105501	8837	110474935
Nerve block	11.66	9.56	8	105519	781	110482991
Calcinosis	11.65	9.56	14	105513	2838	110480934
Allodynia	11.56	9.56	12	105515	2071	110481701
Myotonic dystrophy	11.54	9.56	5	105522	194	110483578
Atelectasis	11.48	9.56	67	105460	36645	110447127
Quadriparesis	11.48	9.56	18	105509	4689	110479083
Activated partial thromboplastin time prolonged	11.45	9.56	47	105480	22321	110461451
Drug tolerance decreased	11.42	9.56	6	105521	27534	110456238
Palpitations	11.42	9.56	97	105430	159115	110324657
Malignant neoplasm progression	11.36	9.56	109	105418	174458	110309314
Obstruction	11.35	9.56	20	105507	5732	110478040
Arthritis bacterial	11.28	9.56	29	105498	10791	110472981
Arthritis fungal	11.26	9.56	5	105522	206	110483566
Intentional product misuse to child	11.24	9.56	5	105522	207	110483565
Vitreous floaters	11.13	9.56	26	105501	9108	110474664
Jaundice	11.13	9.56	25	105502	59211	110424561
End-tidal CO2 decreased	11.12	9.56	4	105523	94	110483678
Product prescribing error	11.07	9.56	20	105507	51311	110432461
Incontinence	11.05	9.56	38	105489	16597	110467175
Anticoagulant therapy	11.05	9.56	19	105508	5342	110478430
Intraocular pressure fluctuation	11.04	9.56	4	105523	96	110483676
Procedural anxiety	11.03	9.56	8	105519	853	110482919
Progressive multifocal leukoencephalopathy	11.01	9.56	5	105522	24951	110458821
Cytokine release syndrome	11.00	9.56	109	105418	70197	110413575
Hypoventilation	10.96	9.56	24	105503	8057	110475715
Hyperlipidaemia	10.94	9.56	65	105462	35783	110447989
Mucosal disorder	10.92	9.56	17	105510	4400	110479372
Dyspepsia	10.90	9.56	123	105404	190842	110292930
Victim of chemical submission	10.88	9.56	8	105519	871	110482901
Meningitis	10.82	9.56	30	105497	11672	110472100
Pneumonia	10.81	9.56	974	104553	875740	109608032
Retinal detachment	10.80	9.56	29	105498	11071	110472701
Dystonia	10.76	9.56	51	105476	25754	110458018
Injection site reaction	10.76	9.56	46	105481	89024	110394748
Antacid therapy	10.73	9.56	19	105508	5465	110478307
Neuroleptic malignant syndrome	10.72	9.56	10	105517	34049	110449723
Anaesthetic complication cardiac	10.70	9.56	4	105523	105	110483667
Hepatocellular injury	10.68	9.56	20	105507	50622	110433150
Diplegia	10.66	9.56	12	105515	2269	110481503
Dysarthria	10.64	9.56	125	105402	83996	110399776
Melaena	10.64	9.56	32	105495	68725	110415047
Thrombosis	10.62	9.56	154	105373	108508	110375264
Hypoglycaemia	10.61	9.56	66	105461	116038	110367734
Deafness bilateral	10.60	9.56	13	105514	2691	110481081
Intercepted medication error	10.60	9.56	9	105518	1207	110482565
Acute pulmonary oedema	10.58	9.56	38	105489	16958	110466814
Dermatitis diaper	10.56	9.56	6	105521	420	110483352
Dry mouth	10.56	9.56	131	105396	199817	110283955
Lymphatic disorder	10.49	9.56	6	105521	425	110483347
Engraftment syndrome	10.49	9.56	11	105516	1921	110481851
Injury	10.47	9.56	232	105295	177033	110306739
Sympathectomy	10.44	9.56	3	105524	33	110483739
Coccygectomy	10.44	9.56	3	105524	33	110483739
Oesophageal obstruction	10.43	9.56	9	105518	1234	110482538
Infusion site nodule	10.42	9.56	6	105521	431	110483341
Brugada syndrome	10.39	9.56	10	105517	1578	110482194
Amaurosis	10.38	9.56	10	105517	1579	110482193
Corneal opacity	10.38	9.56	9	105518	1242	110482530
Injection site joint swelling	10.36	9.56	3	105524	34	110483738
Vasospasm	10.34	9.56	10	105517	1586	110482186
Poor quality product administered	10.30	9.56	17	105510	4624	110479148
Mean arterial pressure increased	10.30	9.56	4	105523	117	110483655
Diabetes mellitus inadequate control	10.28	9.56	8	105519	29767	110454005
Full blood count abnormal	10.26	9.56	24	105503	56028	110427744
Slow response to stimuli	10.23	9.56	11	105516	1977	110481795
Hypercalcaemia	10.22	9.56	18	105509	46639	110437133
Blood pH decreased	10.22	9.56	17	105510	4652	110479120
Cancer pain	10.21	9.56	21	105506	6751	110477021
Induration	10.21	9.56	12	105515	2377	110481395
Cellulitis	10.19	9.56	173	105354	125843	110357929
Ingrowing nail	10.16	9.56	14	105513	3248	110480524
Vascular resistance systemic decreased	10.16	9.56	5	105522	261	110483511
Adverse reaction	10.15	9.56	8	105519	29586	110454186
Tinnitus	10.03	9.56	95	105432	60445	110423327
Thyrotoxic crisis	10.00	9.56	11	105516	2029	110481743
Sinusitis bacterial	9.99	9.56	12	105515	2432	110481340
Incision site rash	9.99	9.56	3	105524	39	110483733
Fear of death	9.98	9.56	10	105517	1657	110482115
Haemorrhagic vasculitis	9.93	9.56	4	105523	129	110483643
Foreign body sensation in eyes	9.93	9.56	14	105513	3320	110480452
Treatment noncompliance	9.90	9.56	36	105491	72954	110410818
Decubitus ulcer	9.88	9.56	39	105488	18197	110465575
Varicose vein	9.86	9.56	21	105506	6919	110476853
Syringomyelia	9.81	9.56	5	105522	281	110483491
Pupil fixed	9.81	9.56	15	105512	3823	110479949
Angioedema	9.78	9.56	140	105387	98360	110385412
Symblepharon	9.76	9.56	6	105521	486	110483286
Poikiloderma	9.76	9.56	6	105521	486	110483286
Oedema peripheral	9.71	9.56	239	105288	328421	110155351
Injection site atrophy	9.68	9.56	6	105521	493	110483279
Muscle strain	9.65	9.56	28	105499	11174	110472598
Tracheal deviation	9.62	9.56	5	105522	293	110483479
Blindness transient	9.62	9.56	19	105508	5937	110477835
Pneumonia mycoplasmal	9.61	9.56	10	105517	1731	110482041

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A07AA05	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Antibiotics
ATC	J01XB02	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Polymyxins
ATC	S01AA18	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
ATC	S02AA11	SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives
ATC	S03AA03	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives
FDA CS	M0017217	Polymyxins
FDA EPC	N0000175499	Polymyxin-class Antibacterial
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000900	Anti-Bacterial Agents
CHEBI has role	CHEBI:35441	antiinfective agent
CHEBI has role	CHEBI:50177	dermatologic drug
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:33281	antimicrobial agent
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:66981	ophthalmology drug

Related Drugs by ATC class:

A07AA Antibiotics 12 drugs

amphotericin B colistin fidaxomicin kanamycin natamycin neomycin nystatin paromomycin rifamycin rifaximin streptomycin vancomycin

J01XB Polymyxins 1 drug

colistin

S01AA Antibiotics 27 drugs

amikacin ampicillin azidamfenicol azithromycin bacitracin benzylpenicillin cefmenoxime cefuroxime chloramphenicol chlortetracycline dibekacin dihydrostreptomycin show all 27 →

S02AA Antiinfectives 17 drugs

acetic acid aluminium acetotartrate boric acid cefmenoxime chloramphenicol chlorhexidine ciprofloxacin clioquinol fosfomycin gentamicin hydrogen peroxide miconazole show all 17 →

S03AA Antiinfectives 7 drugs

chloramphenicol chlorhexidine ciprofloxacin gentamicin hexamidine neomycin tetracycline

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Keratitis	indication	5888003	DOID:4677
Bacterial septicemia	indication	10001005	DOID:0040085
Urinary tract infectious disease	indication	68566005
Blepharoconjunctivitis	indication	68659002	DOID:2456
Corneal abrasion	indication	85848002
Bacterial conjunctivitis	indication	128350005	DOID:9700
Uveitis	indication	128473001	DOID:13141
Infective blepharitis	indication	312219000
Bacterial keratitis	indication	314557000
Superficial Ocular Infection	indication
Minor Bacterial Skin Infections	indication
Minor Skin Wound Pain	indication
Mastoidectomy Cavity Infections	indication
H. Influenzae Meningitis	indication
Chronic purulent otitis media	off-label use	38394007	DOID:14247
Dacryocystitis	off-label use	85777005	DOID:9938
Corneal ulcer	off-label use	91514001	DOID:8463
Meibomianitis	off-label use	309779001
Ocular hypertension	contraindication	4210003	DOID:9282
Herpes simplex keratitis	contraindication	9389005
Herpes zoster auricularis	contraindication	21954000	DOID:9210
Herpes simplex dendritic keratitis	contraindication	29943008
Fungal infection of eye	contraindication	31194008
Bullous myringitis	contraindication	33528003	DOID:13791
Dehydration	contraindication	34095006
Severe myopia	contraindication	34187009
Tuberculosis of eye	contraindication	49107007
Neuromuscular block, function	contraindication	55394004
Perforation of tympanic membrane	contraindication	60442001
Diabetes mellitus	contraindication	73211009	DOID:9351
Third degree burn injury	contraindication	80247002
Oliguria	contraindication	83128009
Open-angle glaucoma	contraindication	84494001	DOID:1067
Krukenberg spindle	contraindication	85430004
Herpes simplex	contraindication	88594005	DOID:8566
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Procedure on urinary system	contraindication	118677009
Open wound	contraindication	125643001
Eye infection	contraindication	128351009
Hearing disorder	contraindication	128540005
Bacterial infection of eye	contraindication	128984004
Tuberculosis of ear	contraindication	186269001
Telangiectasia disorder	contraindication	247479008
Rupture of bladder	contraindication	251925007
Injury of eye region	contraindication	282752000
Pregnancy, function	contraindication	289908002
Viral eye infection	contraindication	312132001
Viral ear infection	contraindication	312137007
Fungal ear infection	contraindication	312148000
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Vaccinia keratitis	contraindication	397552005
Atrophoderma	contraindication	399979006
Peripheral vascular disease	contraindication	400047006

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Inflammation associated with topical ophthalmological conditions of the eye	Indication
Cats	Edema associated with topical ophthalmological conditions of the eye	Indication
Cats	Secondary bacterial infections associated with topical ophthalmological conditions of the eye	Indication
Cattle	Superficial ocular infections	Indication
Cattle	Infections caused by streptococci	Indication
Cattle	Infections caused by rickettsiae	Indication
Cattle	Infections caused by Escherichia coli	Indication
Cattle	Infections caused by A aerogenes	Indication
Dogs	Inflammation associated with topical ophthalmological conditions of the eye	Indication
Dogs	Edema associated with topical ophthalmological conditions of the eye	Indication
Dogs	Secondary bacterial infections associated with topical ophthalmological conditions of the eye	Indication
Horses	Inflammation associated with topical ophthalmological conditions of the eye	Indication
Horses	Edema associated with topical ophthalmological conditions of the eye	Indication
Horses	Secondary bacterial infections associated with topical ophthalmological conditions of the eye	Indication
Sheep	Inflammation associated with topical ophthalmological conditions of the eye	Indication
Sheep	Edema associated with topical ophthalmological conditions of the eye	Indication
Sheep	Secondary bacterial infections associated with topical ophthalmological conditions of the eye	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Terramycin Ophthalmic Ointment with Polymyxin	Zoetis Inc.	2
Anaprime Ophthalmic Solution	Zoetis Inc.	3
Anaprime Opthakote Ophthalmic	Zoetis Inc.	3
Optiprime Opthakote Ophthalmic Solution	Zoetis Inc.	2
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment	Dechra, Ltd.	4
Bac-Neo-Poly Ophthalmic Ointment, Vetropolycin Ophthalmic Ointment	Dechra, Ltd.	3
Mycitracin Sterile Ophthalmic Ointment	Zoetis Inc.	3
Forte Topical Ointment	Zoetis Inc.	4
Cortisporin Veterinary Ophthalmic Ointment	Intervet Inc.	4
Neosporin Ophthalmic Ointment	Intervet Inc.	3
Surolan	Elanco US Inc.	3
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment	Akorn Animal Health Inc.	3

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018100	VUID
N0000146438	NUI
D08401	KEGG_DRUG
1404-26-8	SECONDARY_CAS_RN
4018100	VANDF
4018594	VANDF
C0032535	UMLSCUI
CHEBI:759086	CHEBI
CHEMBL5314354	ChEMBL_ID
CHEMBL5314355	ChEMBL_ID
D011112	MESH_DESCRIPTOR_UI
DB00781	DRUGBANK_ID
10338	IUPHAR_LIGAND_ID
490	INN_ID
J2VZ07J96K	UNII
202404	RXNORM
1703	MMSL
5317	MMSL
5318	MMSL
d00344	MMSL
002803	NDDF
004902	NDDF
372824005	SNOMEDCT_US
61360007	SNOMEDCT_US
6960003	SNOMEDCT_US
5702105	PUBCHEM_CID
J2VZ07J96K	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
MAXITROL	HUMAN PRESCRIPTION DRUG LABEL	3	0078-0771	OINTMENT	10000 [USPU]	OPHTHALMIC	NDA	18 sections
Good Sense First Aid Antibiotic	HUMAN OTC DRUG LABEL	3	0113-0084	OINTMENT	5000 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
Good Sense Triple Antibioticand Pain Relief	HUMAN OTC DRUG LABEL	4	0113-0679	OINTMENT	10000 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
good sense triple antibiotic	HUMAN OTC DRUG LABEL	4	0113-1140	OINTMENT	10000 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
Polymyxin B	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9461	INJECTION, POWDER, FOR SOLUTION	500000 [USPU]	INTRAMUSCULAR	ANDA	12 sections
Polymyxin B	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9941	INJECTION, POWDER, FOR SOLUTION	500000 [iU]	INTRAMUSCULAR	ANDA	14 sections
Bacitracin Zinc and Polymyxin B Sulfate	HUMAN PRESCRIPTION DRUG LABEL	2	0168-0273	OINTMENT	10000 1	OPHTHALMIC	ANDA	17 sections
AntibioticMaximum Strength	HUMAN OTC DRUG LABEL	3	0363-0018	OINTMENT	10000 [iU]	TOPICAL	OTC Monograph Drug	13 sections
Triple Antibiotic with Pain ReliefMaximum Strength	HUMAN OTC DRUG LABEL	4	0363-0123	OINTMENT	10000 [USPU]	TOPICAL	OTC MONOGRAPH FINAL	13 sections
triple antibiotic	HUMAN OTC DRUG LABEL	3	0363-0539	OINTMENT	5000 [USPU]	TOPICAL	OTC Monograph Drug	14 sections
First Aid Antibiotic	HUMAN OTC DRUG LABEL	4	0363-0841	OINTMENT	10000 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
ANTIBIOTICMaximum Strength	Human OTC Drug Label	3	0363-1331	OINTMENT	10000 [iU]	TOPICAL	OTC Monograph Drug	13 sections
triple antibiotic	Human OTC Drug Label	3	0363-1332	OINTMENT	5000 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Triple Antibiotic	HUMAN OTC DRUG LABEL	3	0363-2016	OINTMENT	5000 [iU]	TOPICAL	OTC MONOGRAPH FINAL	14 sections
Walgreens Kids Multi-Antibiotic with Pain Relief Cream	HUMAN OTC DRUG LABEL	3	0363-2122	CREAM	10000 [USPU]	TOPICAL	OTC Monograph Drug	11 sections
Walgreens Multi-Antibiotic with Pain Relief Cream	HUMAN OTC DRUG LABEL	3	0363-2123	CREAM	10000 [USPU]	TOPICAL	OTC Monograph Drug	9 sections
triple antibiotic pain relief	HUMAN OTC DRUG LABEL	4	0363-6790	OINTMENT	10000 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Maximum Strength Triple Antibiotic With Pain Relief	HUMAN OTC DRUG LABEL	4	0363-7872	OINTMENT	1000 [USPU]	TOPICAL	OTC monograph final	11 sections
Walgreens Wal-Sporin First Aid Antibiotic	HUMAN OTC DRUG LABEL	2	0363-8821	OINTMENT	10000 [USPU]	TOPICAL	OTC monograph final	12 sections
Triple Antibiotic Plus Pain Relief	HUMAN OTC DRUG LABEL	4	0363-8888	OINTMENT	10000 [USPU]	TOPICAL	OTC Monograph Drug	14 sections
Bacitracin Zinc, Neomycin Sulfate, and Polymyxin B Sulfate	HUMAN OTC DRUG LABEL	3	0404-0167	OINTMENT	5000 [iU]	TOPICAL	OTC Monograph Drug	12 sections
Bacitracin Zinc, Polymyxin B Sulfate, and Neomycin Sulfate	HUMAN OTC DRUG LABEL	3	0404-0171	OINTMENT	50000 [iU]	TOPICAL	OTC Monograph Drug	12 sections
Triple Antibiotic	HUMAN OTC DRUG LABEL	3	0713-0268	OINTMENT	5000 [USPU]	TOPICAL	OTC Monograph Drug	9 sections
Triple Antibiotic Plus	HUMAN OTC DRUG LABEL	4	0713-0622	OINTMENT	10000 [USPU]	TOPICAL	OTC Monograph Drug	9 sections
Major Triple Antibiotic	HUMAN OTC DRUG LABEL	3	0904-8805	OINTMENT	5000 [USPU]	TOPICAL	OTC Monograph Drug	15 sections
triple antibiotic	HUMAN OTC DRUG LABEL	3	0924-5603	OINTMENT	5000 [iU]	TOPICAL	OTC monograph final	11 sections
triple antibiotic	HUMAN OTC DRUG LABEL	3	0924-5603	OINTMENT	5000 [iU]	TOPICAL	OTC monograph final	11 sections
triple antibiotic	HUMAN OTC DRUG LABEL	3	0924-5603	OINTMENT	5000 [iU]	TOPICAL	OTC monograph final	11 sections
Triple Antibiotic	HUMAN OTC DRUG LABEL	3	0924-5604	OINTMENT	5000 [iU]	TOPICAL	OTC Monograph Drug	12 sections
First Aid Only Triple Antibiotic	HUMAN OTC DRUG LABEL	3	0924-5605	OINTMENT	5322.80 [iU]	TOPICAL	OTC monograph final	12 sections

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Polymyxin B 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: