| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4246 | 1405-20-5 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.
|
| Dose | Unit | Route |
|---|---|---|
| 3 | MU | O |
| 0.15 | g | P |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 26, 1957 | FDA | MONARCH PHARMS |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 875.37 | 14.99 | 497 | 6497 | 264745 | 53077327 |
| Macular degeneration | 234.00 | 14.99 | 80 | 6914 | 12281 | 53329791 |
| Eye irritation | 113.22 | 14.99 | 53 | 6941 | 18396 | 53323676 |
| Ocular hyperaemia | 82.05 | 14.99 | 45 | 6949 | 21746 | 53320326 |
| Eye pain | 77.60 | 14.99 | 49 | 6945 | 30676 | 53311396 |
| Eye pruritus | 59.65 | 14.99 | 31 | 6963 | 13438 | 53328634 |
| Retinal pigment epitheliopathy | 53.79 | 14.99 | 11 | 6983 | 222 | 53341850 |
| Punctate keratitis | 48.09 | 14.99 | 12 | 6982 | 605 | 53341467 |
| Corneal disorder | 43.56 | 14.99 | 14 | 6980 | 1767 | 53340305 |
| Ulcerative keratitis | 39.08 | 14.99 | 14 | 6980 | 2455 | 53339617 |
| Vulval cancer stage III | 31.86 | 14.99 | 5 | 6989 | 19 | 53342053 |
| Endophthalmitis | 30.63 | 14.99 | 13 | 6981 | 3574 | 53338498 |
| Rash | 30.29 | 14.99 | 127 | 6867 | 446064 | 52896008 |
| Corneal abrasion | 29.69 | 14.99 | 9 | 6985 | 937 | 53341135 |
| Cytomegalovirus test positive | 29.67 | 14.99 | 12 | 6982 | 2923 | 53339149 |
| Vision blurred | 27.42 | 14.99 | 44 | 6950 | 85560 | 53256512 |
| Septic arthritis staphylococcal | 26.67 | 14.99 | 7 | 6987 | 432 | 53341640 |
| Foreign body sensation in eyes | 26.49 | 14.99 | 10 | 6984 | 2029 | 53340043 |
| Eye swelling | 25.88 | 14.99 | 22 | 6972 | 21672 | 53320400 |
| Drug ineffective | 24.19 | 14.99 | 186 | 6808 | 817059 | 52525013 |
| Infectious thyroiditis | 23.09 | 14.99 | 4 | 6990 | 31 | 53342041 |
| Lymphatic disorder | 22.72 | 14.99 | 6 | 6988 | 379 | 53341693 |
| Respiratory failure | 22.30 | 14.99 | 44 | 6950 | 100468 | 53241604 |
| Lacrimation increased | 21.03 | 14.99 | 18 | 6976 | 17885 | 53324187 |
| Corneal perforation | 21.00 | 14.99 | 6 | 6988 | 508 | 53341564 |
| Eye infection | 20.69 | 14.99 | 14 | 6980 | 9824 | 53332248 |
| Persistent corneal epithelial defect | 19.42 | 14.99 | 3 | 6991 | 10 | 53342062 |
| Visual acuity reduced | 19.37 | 14.99 | 19 | 6975 | 22466 | 53319606 |
| Ear discomfort | 19.31 | 14.99 | 12 | 6982 | 7289 | 53334783 |
| Ear infection | 18.88 | 14.99 | 20 | 6974 | 25880 | 53316192 |
| Corneal thinning | 18.10 | 14.99 | 4 | 6990 | 118 | 53341954 |
| Engraft failure | 17.97 | 14.99 | 5 | 6989 | 385 | 53341687 |
| Product dispensing error | 17.87 | 14.99 | 13 | 6981 | 10227 | 53331845 |
| Visual impairment | 17.49 | 14.99 | 33 | 6961 | 72879 | 53269193 |
| Infective keratitis | 15.27 | 14.99 | 3 | 6991 | 49 | 53342023 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 101.89 | 16.49 | 89 | 5227 | 73311 | 32434899 |
| Eye irritation | 45.71 | 16.49 | 22 | 5294 | 6496 | 32501714 |
| Respiratory paralysis | 37.45 | 16.49 | 7 | 5309 | 68 | 32508142 |
| Ulcerative keratitis | 30.84 | 16.49 | 11 | 5305 | 1525 | 32506685 |
| Eye pain | 29.34 | 16.49 | 21 | 5295 | 12927 | 32495283 |
| Mucosal disorder | 25.95 | 16.49 | 10 | 5306 | 1719 | 32506491 |
| Uveitis-glaucoma-hyphaema syndrome | 23.55 | 16.49 | 4 | 5312 | 21 | 32508189 |
| Disseminated intravascular coagulation | 22.30 | 16.49 | 23 | 5293 | 23153 | 32485057 |
| Dermatitis contact | 22.11 | 16.49 | 11 | 5305 | 3487 | 32504723 |
| Central vision loss | 21.98 | 16.49 | 4 | 5312 | 33 | 32508177 |
| Chronic graft versus host disease | 19.64 | 16.49 | 11 | 5305 | 4429 | 32503781 |
| Sepsis | 18.93 | 16.49 | 63 | 5253 | 158771 | 32349439 |
| Bacterial translocation | 18.39 | 16.49 | 5 | 5311 | 282 | 32507928 |
| Trichosporon infection | 17.13 | 16.49 | 6 | 5310 | 789 | 32507421 |
| Source | Code | Description |
|---|---|---|
| ATC | A07AA05 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Antibiotics |
| ATC | J01XB02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Polymyxins |
| ATC | S01AA18 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
| ATC | S02AA11 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
| ATC | S03AA03 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives |
| FDA CS | M0017217 | Polymyxins |
| FDA EPC | N0000175499 | Polymyxin-class Antibacterial |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Otitis externa | indication | 3135009 | |
| Keratitis | indication | 5888003 | DOID:4677 |
| Bacterial septicemia | indication | 10001005 | DOID:0040085 |
| Urinary tract infectious disease | indication | 68566005 | |
| Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
| Corneal abrasion | indication | 85848002 | |
| Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
| Uveitis | indication | 128473001 | DOID:13141 |
| Infective blepharitis | indication | 312219000 | |
| Bacterial keratitis | indication | 314557000 | |
| Superficial Ocular Infection | indication | ||
| Minor Bacterial Skin Infections | indication | ||
| Minor Skin Wound Pain | indication | ||
| Mastoidectomy Cavity Infections | indication | ||
| H. Influenzae Meningitis | indication | ||
| Chronic purulent otitis media | off-label use | 38394007 | DOID:14247 |
| Dacryocystitis | off-label use | 85777005 | DOID:9938 |
| Corneal ulcer | off-label use | 91514001 | DOID:8463 |
| Meibomianitis | off-label use | 309779001 | |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Herpes simplex keratitis | contraindication | 9389005 | |
| Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
| Herpes simplex dendritic keratitis | contraindication | 29943008 | |
| Fungal infection of eye | contraindication | 31194008 | |
| Bullous myringitis | contraindication | 33528003 | DOID:13791 |
| Dehydration | contraindication | 34095006 | |
| Severe myopia | contraindication | 34187009 | |
| Tuberculosis of eye | contraindication | 49107007 | |
| Neuromuscular block, function | contraindication | 55394004 | |
| Perforation of tympanic membrane | contraindication | 60442001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Third degree burn injury | contraindication | 80247002 | |
| Oliguria | contraindication | 83128009 | |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Krukenberg spindle | contraindication | 85430004 | |
| Herpes simplex | contraindication | 88594005 | DOID:8566 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Procedure on urinary system | contraindication | 118677009 | |
| Open wound | contraindication | 125643001 | |
| Eye infection | contraindication | 128351009 | |
| Hearing disorder | contraindication | 128540005 | |
| Bacterial infection of eye | contraindication | 128984004 | |
| Tuberculosis of ear | contraindication | 186269001 | |
| Telangiectasia disorder | contraindication | 247479008 | |
| Rupture of bladder | contraindication | 251925007 | |
| Injury of eye region | contraindication | 282752000 | |
| Pregnancy, function | contraindication | 289908002 | |
| Viral eye infection | contraindication | 312132001 | |
| Viral ear infection | contraindication | 312137007 | |
| Fungal ear infection | contraindication | 312148000 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Vaccinia keratitis | contraindication | 397552005 | |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 |
None
None
None
None
| ID | Source |
|---|---|
| 4018100 | VUID |
| N0000146438 | NUI |
| D08401 | KEGG_DRUG |
| 4018100 | VANDF |
| 4018594 | VANDF |
| C0032535 | UMLSCUI |
| CHEBI:8310 | CHEBI |
| CHEMBL3989738 | ChEMBL_ID |
| CHEMBL3989714 | ChEMBL_ID |
| D011112 | MESH_DESCRIPTOR_UI |
| DB00781 | DRUGBANK_ID |
| 10338 | IUPHAR_LIGAND_ID |
| 490 | INN_ID |
| 1404-26-8 | SECONDARY_CAS_RN |
| J2VZ07J96K | UNII |
| 4868 | PUBCHEM_CID |
| 202404 | RXNORM |
| 1703 | MMSL |
| 5317 | MMSL |
| 5318 | MMSL |
| d00344 | MMSL |
| 002803 | NDDF |
| 004902 | NDDF |
| 372824005 | SNOMEDCT_US |
| 61360007 | SNOMEDCT_US |
| 6960003 | SNOMEDCT_US |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Polytrim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-7824 | SOLUTION/ DROPS | 100000 [USPU] | OPHTHALMIC | NDA | 19 sections |
| MAXITROL | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0065-0631 | OINTMENT | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
| MAXITROL | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0771 | OINTMENT | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
| Good Sense First Aid Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0113-0084 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
| Good Sense Triple Antibioticand Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-0679 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
| basic care first aid antibiotic | HUMAN OTC DRUG LABEL | 3 | 0113-0701 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
| good sense triple antibiotic | HUMAN OTC DRUG LABEL | 4 | 0113-1140 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
| Basic Care First Aid Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-7679 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
| Bacitracin Zinc and Polymyxin B Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0168-0273 | OINTMENT | 10000 1 | OPHTHALMIC | ANDA | 17 sections |
| Kaiser PermanenteDouble antibiotic | HUMAN OTC DRUG LABEL | 2 | 0179-8707 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 14 sections |
| AntibioticMaximum Strength | HUMAN OTC DRUG LABEL | 3 | 0363-0018 | OINTMENT | 10000 [iU] | TOPICAL | OTC monograph final | 13 sections |
| Triple Antibiotic with Pain ReliefMaximum Strength | HUMAN OTC DRUG LABEL | 4 | 0363-0123 | OINTMENT | 10000 [USPU] | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
| Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0179 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 13 sections |
| triple antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0539 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 14 sections |
| First Aid Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-0841 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
| Walgreens Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-2016 | OINTMENT | 5000 [iU] | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| Walgreens Multi-Antibiotic with Pain Relief Cream | HUMAN OTC DRUG LABEL | 3 | 0363-2123 | CREAM | 10000 [USPU] | TOPICAL | OTC monograph not final | 9 sections |
| Triple Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-2900 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
| Walgreens Maximum Strength Triple Antibiotic With Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-7872 | OINTMENT | 1000 [USPU] | TOPICAL | OTC monograph final | 11 sections |
| Walgreens Wal-Sporin First Aid Antibiotic | HUMAN OTC DRUG LABEL | 2 | 0363-8821 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 12 sections |
| Triple Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-8888 | OINTMENT | 10000 [USPU] | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| Schein Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0404-0360 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 8 sections |
| Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0404-7194 | OINTMENT | 10000 [USPU] | OPHTHALMIC | ANDA | 19 sections |
| Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0404-7195 | OINTMENT | 10000 [USPU] | OPHTHALMIC | ANDA | 19 sections |
| Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0472-0179 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 14 sections |
| North Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0498-0740 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 13 sections |
| Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0498-0750 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 13 sections |
| Double Antibiotic | HUMAN OTC DRUG LABEL | 2 | 0536-1174 | OINTMENT | 10000 [USPU] | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| polycin | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0574-4021 | OINTMENT | 10000 [USPU] | OPHTHALMIC | ANDA | 19 sections |
| Neo Polycin HC | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0574-4144 | OINTMENT | 10000 [USPU] | OPHTHALMIC | ANDA | 20 sections |