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bekanamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, produced by Streptomyces strains | 1520 | 4696-76-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
kanendomycin is the sulfate of bekanamycin; RN given refers to parent cpd; structure
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.60 | g | P |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK4,CDK5,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK1,NTRK2,PDK2,PDK4,PRKDC,TEK | 21 | |||
| kinase-selectivity-class | CHUK,IRAK4,MAP2K6,PDK1 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01GB13 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMINOGLYCOSIDE ANTIBACTERIALS Other aminoglycosides |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
Related Drugs by ATC class:
J01GB Other aminoglycosides 12 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.0 | acidic |
| pKa2 | 13.56 | acidic |
| pKa3 | 13.99 | acidic |
| pKa4 | 8.03 | Basic |
| pKa5 | 7.6 | Basic |
| pKa6 | 7.07 | Basic |
| pKa7 | 6.11 | Basic |
| pKa8 | 5.41 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 3-oxoacyl-[acyl-carrier-protein] synthase 3 | Enzyme | IC50 | 5.20 | CHEMBL | |||||
| 3-oxoacyl-[acyl-carrier-protein] synthase 3 | Enzyme | IC50 | 5.25 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07497 | KEGG_DRUG |
| C0053076 | UMLSCUI |
| CHEBI:28098 | CHEBI |
| 9CS | PDB_CHEM_ID |
| CHEMBL176 | ChEMBL_ID |
| DB13673 | DRUGBANK_ID |
| C001495 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12182 | IUPHAR_LIGAND_ID |
| 2838 | INN_ID |
| 15JT14C3GI | UNII |
| 439318 | PUBCHEM_CID |
Pharmaceutical products:
None