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| Stem definition | Drug id | CAS RN |
|---|---|---|
| aminoacyl-tRNA synthetase inhibitors | 1857 | 12650-69-0 |
None
None
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,SYK,TEK,TGFBR1,ZAP70 | 26 | |||
| kinase-selectivity-class | AXL,EIF2AK3,GRK2,MAP2K6 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 31, 1987 | FDA | GLAXOSMITHKLINE |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Macular degeneration | 1211.93 | 15.01 | 419 | 20613 | 37551 | 90569864 |
| Chronic sinusitis | 422.15 | 15.01 | 171 | 20861 | 23631 | 90583784 |
| Vaginal flatulence | 362.43 | 15.01 | 129 | 20903 | 12509 | 90594906 |
| Paraesthesia oral | 359.48 | 15.01 | 166 | 20866 | 31493 | 90575922 |
| Female genital tract fistula | 343.25 | 15.01 | 136 | 20896 | 17732 | 90589683 |
| Proctitis | 338.72 | 15.01 | 129 | 20903 | 15130 | 90592285 |
| Radiculopathy | 335.18 | 15.01 | 135 | 20897 | 18370 | 90589045 |
| Vaginal discharge | 311.65 | 15.01 | 130 | 20902 | 19334 | 90588081 |
| Procedural pain | 299.86 | 15.01 | 149 | 20883 | 33211 | 90574204 |
| Oral candidiasis | 259.75 | 15.01 | 138 | 20894 | 35317 | 90572098 |
| Colitis | 215.98 | 15.01 | 157 | 20875 | 69785 | 90537630 |
| Colitis ulcerative | 210.85 | 15.01 | 146 | 20886 | 60120 | 90547295 |
| Therapeutic product effect incomplete | 204.32 | 15.01 | 238 | 20794 | 193658 | 90413757 |
| Frequent bowel movements | 187.67 | 15.01 | 133 | 20899 | 56802 | 90550613 |
| Rectal haemorrhage | 173.84 | 15.01 | 148 | 20884 | 82596 | 90524819 |
| Haematochezia | 172.27 | 15.01 | 138 | 20894 | 70775 | 90536640 |
| Erythema | 141.91 | 15.01 | 217 | 20815 | 229029 | 90378386 |
| Dermatitis atopic | 132.52 | 15.01 | 77 | 20955 | 23395 | 90584020 |
| Drug ineffective | 131.24 | 15.01 | 649 | 20383 | 1383649 | 89223766 |
| Weight decreased | 129.13 | 15.01 | 277 | 20755 | 379633 | 90227782 |
| Dyspepsia | 109.31 | 15.01 | 178 | 20854 | 197982 | 90409433 |
| Dry skin | 85.81 | 15.01 | 104 | 20928 | 87969 | 90519446 |
| Constipation | 81.20 | 15.01 | 192 | 20840 | 280203 | 90327212 |
| Skin exfoliation | 72.43 | 15.01 | 84 | 20948 | 67829 | 90539586 |
| Anaemia | 71.02 | 15.01 | 211 | 20821 | 352591 | 90254824 |
| Systemic lupus erythematosus | 55.02 | 15.01 | 9 | 21023 | 361887 | 90245528 |
| Skin weeping | 52.65 | 15.01 | 21 | 21011 | 2779 | 90604636 |
| Toxicity to various agents | 51.63 | 15.01 | 4 | 21028 | 287842 | 90319573 |
| General physical health deterioration | 47.41 | 15.01 | 12 | 21020 | 355103 | 90252312 |
| Pyrexia | 44.84 | 15.01 | 284 | 20748 | 660201 | 89947214 |
| Hepatic enzyme increased | 44.79 | 15.01 | 14 | 21018 | 360722 | 90246693 |
| Abdominal pain | 44.69 | 15.01 | 196 | 20836 | 395525 | 90211890 |
| Malaise | 42.92 | 15.01 | 257 | 20775 | 585729 | 90021686 |
| Eczema | 41.34 | 15.01 | 56 | 20976 | 52814 | 90554601 |
| Therapeutic product effect decreased | 39.80 | 15.01 | 8 | 21024 | 277563 | 90329852 |
| Skin fissures | 39.18 | 15.01 | 35 | 20997 | 20774 | 90586641 |
| Headache | 39.14 | 15.01 | 337 | 20695 | 862409 | 89745006 |
| Hyperchlorhydria | 38.04 | 15.01 | 15 | 21017 | 1926 | 90605489 |
| Staphylococcal infection | 37.40 | 15.01 | 51 | 20981 | 48388 | 90559027 |
| Nasal vestibulitis | 37.05 | 15.01 | 8 | 21024 | 116 | 90607299 |
| Nausea | 35.42 | 15.01 | 403 | 20629 | 1109913 | 89497502 |
| Lower respiratory tract infection | 34.36 | 15.01 | 8 | 21024 | 250651 | 90356764 |
| Contraindicated product administered | 33.81 | 15.01 | 16 | 21016 | 320123 | 90287292 |
| Maternal exposure during pregnancy | 33.65 | 15.01 | 21 | 21011 | 360042 | 90247373 |
| Arthropathy | 32.02 | 15.01 | 23 | 21009 | 366219 | 90241196 |
| Folliculitis | 31.22 | 15.01 | 5 | 21027 | 204348 | 90403067 |
| Folate deficiency | 30.99 | 15.01 | 15 | 21017 | 3150 | 90604265 |
| Swelling | 30.91 | 15.01 | 31 | 21001 | 419027 | 90188388 |
| Skin warm | 30.13 | 15.01 | 20 | 21012 | 7667 | 90599748 |
| Confusional state | 29.14 | 15.01 | 28 | 21004 | 386177 | 90221238 |
| Purpura senile | 28.44 | 15.01 | 9 | 21023 | 606 | 90606809 |
| Exposure during pregnancy | 28.27 | 15.01 | 10 | 21022 | 238400 | 90369015 |
| Drug intolerance | 27.76 | 15.01 | 38 | 20994 | 447553 | 90159862 |
| Humidity intolerance | 27.36 | 15.01 | 8 | 21024 | 412 | 90607003 |
| Skin haemorrhage | 27.18 | 15.01 | 29 | 21003 | 21351 | 90586064 |
| Hypersensitivity | 26.82 | 15.01 | 40 | 20992 | 454637 | 90152778 |
| Fibromyalgia | 25.59 | 15.01 | 8 | 21024 | 206261 | 90401154 |
| Pain | 25.41 | 15.01 | 347 | 20685 | 995994 | 89611421 |
| Tarsal tunnel syndrome | 24.86 | 15.01 | 8 | 21024 | 569 | 90606846 |
| Product dose omission issue | 24.62 | 15.01 | 133 | 20899 | 291554 | 90315861 |
| Mobility decreased | 22.90 | 15.01 | 15 | 21017 | 250719 | 90356696 |
| Appetite disorder | 22.63 | 15.01 | 18 | 21014 | 9115 | 90598300 |
| Skin lesion | 22.53 | 15.01 | 35 | 20997 | 37330 | 90570085 |
| Autoimmune pericarditis | 21.99 | 15.01 | 5 | 21027 | 93 | 90607322 |
| Type 2 diabetes mellitus | 21.69 | 15.01 | 10 | 21022 | 203234 | 90404181 |
| Pruritus | 21.63 | 15.01 | 206 | 20826 | 541319 | 90066096 |
| Ill-defined disorder | 21.50 | 15.01 | 8 | 21024 | 184883 | 90422532 |
| Impaired healing | 21.40 | 15.01 | 14 | 21018 | 234185 | 90373230 |
| Product use in unapproved indication | 21.15 | 15.01 | 142 | 20890 | 336094 | 90271321 |
| Irritable bowel syndrome | 20.94 | 15.01 | 11 | 21021 | 207437 | 90399978 |
| Treatment failure | 20.71 | 15.01 | 24 | 21008 | 303904 | 90303511 |
| Bursitis | 20.61 | 15.01 | 3 | 21029 | 131651 | 90475764 |
| Injection site pain | 20.29 | 15.01 | 87 | 20945 | 173612 | 90433803 |
| Sleep disorder due to general medical condition, insomnia type | 19.99 | 15.01 | 3 | 21029 | 128691 | 90478724 |
| Dermatitis | 19.63 | 15.01 | 25 | 21007 | 22195 | 90585220 |
| Cellulitis | 19.63 | 15.01 | 56 | 20976 | 91281 | 90516134 |
| Staphylococcal scalded skin syndrome | 19.61 | 15.01 | 5 | 21027 | 153 | 90607262 |
| Joint range of motion decreased | 19.24 | 15.01 | 4 | 21028 | 135639 | 90471776 |
| Off label use | 19.08 | 15.01 | 360 | 20672 | 1101892 | 89505523 |
| Resorption bone increased | 19.02 | 15.01 | 8 | 21024 | 1211 | 90606204 |
| Joint swelling | 18.99 | 15.01 | 57 | 20975 | 503243 | 90104172 |
| Infusion related reaction | 18.90 | 15.01 | 163 | 20869 | 416617 | 90190798 |
| Odynophagia | 18.60 | 15.01 | 16 | 21016 | 9027 | 90598388 |
| Wound | 18.49 | 15.01 | 26 | 21006 | 302954 | 90304461 |
| Rash pruritic | 18.25 | 15.01 | 51 | 20981 | 82163 | 90525252 |
| Therapeutic product effect delayed | 18.08 | 15.01 | 11 | 21021 | 3630 | 90603785 |
| Sleep disorder due to a general medical condition | 17.93 | 15.01 | 35 | 20997 | 44703 | 90562712 |
| Injury | 17.75 | 15.01 | 12 | 21020 | 197337 | 90410078 |
| Skin disorder | 17.58 | 15.01 | 31 | 21001 | 36675 | 90570740 |
| Weight increased | 17.50 | 15.01 | 45 | 20987 | 417882 | 90189533 |
| Spinal synovial cyst | 17.46 | 15.01 | 4 | 21028 | 77 | 90607338 |
| Musculoskeletal pain | 17.40 | 15.01 | 9 | 21023 | 171242 | 90436173 |
| Illness | 17.37 | 15.01 | 50 | 20982 | 81919 | 90525496 |
| Stomatitis | 17.34 | 15.01 | 23 | 21009 | 274675 | 90332740 |
| Injection site swelling | 17.29 | 15.01 | 41 | 20991 | 59798 | 90547617 |
| Skin infection | 17.22 | 15.01 | 21 | 21011 | 17843 | 90589572 |
| Intentional product use issue | 17.20 | 15.01 | 15 | 21017 | 216877 | 90390538 |
| Vestibular disorder | 17.18 | 15.01 | 8 | 21024 | 1541 | 90605874 |
| Dysphoria | 17.14 | 15.01 | 13 | 21019 | 6141 | 90601274 |
| Hypertension | 17.13 | 15.01 | 52 | 20980 | 457480 | 90149935 |
| Linear IgA disease | 17.06 | 15.01 | 9 | 21023 | 2265 | 90605150 |
| Blood cholesterol increased | 16.97 | 15.01 | 14 | 21018 | 207998 | 90399417 |
| Skin irritation | 16.50 | 15.01 | 18 | 21014 | 13585 | 90593830 |
| Bronchial oedema | 16.43 | 15.01 | 4 | 21028 | 101 | 90607314 |
| Seborrhoeic dermatitis | 16.38 | 15.01 | 8 | 21024 | 1712 | 90605703 |
| Discomfort | 16.29 | 15.01 | 24 | 21008 | 274311 | 90333104 |
| Alopecia | 15.98 | 15.01 | 60 | 20972 | 495011 | 90112404 |
| Musculoskeletal stiffness | 15.68 | 15.01 | 28 | 21004 | 296504 | 90310911 |
| Pain of skin | 15.66 | 15.01 | 19 | 21013 | 16063 | 90591352 |
| Cough | 15.53 | 15.01 | 142 | 20890 | 368820 | 90238595 |
| Pustule | 15.06 | 15.01 | 9 | 21023 | 2874 | 90604541 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Dermatitis atopic | 154.66 | 15.92 | 66 | 8275 | 12338 | 42600656 |
| Pruritus | 72.30 | 15.92 | 131 | 8210 | 188640 | 42424354 |
| Nasal vestibulitis | 57.65 | 15.92 | 9 | 8332 | 19 | 42612975 |
| Dry skin | 47.91 | 15.92 | 53 | 8288 | 48285 | 42564709 |
| Product use in unapproved indication | 44.58 | 15.92 | 106 | 8235 | 184350 | 42428644 |
| Skin exfoliation | 41.93 | 15.92 | 46 | 8295 | 41507 | 42571487 |
| Skin fissures | 38.87 | 15.92 | 24 | 8317 | 9652 | 42603342 |
| Staphylococcal infection | 38.55 | 15.92 | 42 | 8299 | 37601 | 42575393 |
| Food aversion | 35.97 | 15.92 | 10 | 8331 | 511 | 42612483 |
| Injection site pain | 34.23 | 15.92 | 49 | 8292 | 57749 | 42555245 |
| Rash | 33.96 | 15.92 | 125 | 8216 | 276829 | 42336165 |
| Seborrhoeic keratosis | 28.01 | 15.92 | 11 | 8330 | 1660 | 42611334 |
| Eczema | 26.47 | 15.92 | 33 | 8308 | 34053 | 42578941 |
| Toxic epidermal necrolysis | 25.92 | 15.92 | 29 | 8312 | 26721 | 42586273 |
| Burkholderia test positive | 25.23 | 15.92 | 9 | 8332 | 1041 | 42611953 |
| Pain of skin | 24.97 | 15.92 | 17 | 8324 | 8063 | 42604931 |
| Cheilitis | 23.29 | 15.92 | 11 | 8330 | 2597 | 42610397 |
| Sleep disorder due to a general medical condition | 22.42 | 15.92 | 22 | 8319 | 17431 | 42595563 |
| Hordeolum | 21.53 | 15.92 | 9 | 8332 | 1593 | 42611401 |
| Cellulitis | 21.30 | 15.92 | 41 | 8300 | 61544 | 42551450 |
| Dermatitis | 21.19 | 15.92 | 18 | 8323 | 11857 | 42601137 |
| Skin discolouration | 20.84 | 15.92 | 23 | 8318 | 20867 | 42592127 |
| Skin discomfort | 20.33 | 15.92 | 7 | 8334 | 729 | 42612265 |
| Product dose omission issue | 19.98 | 15.92 | 71 | 8270 | 154294 | 42458700 |
| Toxicity to various agents | 19.91 | 15.92 | 10 | 8331 | 229126 | 42383868 |
| Lentigo | 19.48 | 15.92 | 7 | 8334 | 827 | 42612167 |
| Scratch | 18.51 | 15.92 | 12 | 8329 | 5249 | 42607745 |
| Skin weeping | 18.34 | 15.92 | 8 | 8333 | 1571 | 42611423 |
| Cutaneous T-cell lymphoma | 16.54 | 15.92 | 8 | 8333 | 1990 | 42611004 |
| Urine phosphorus increased | 16.20 | 15.92 | 4 | 8337 | 128 | 42612866 |
| Melanocytic naevus | 16.18 | 15.92 | 9 | 8332 | 2983 | 42610011 |
| Hypophagia | 16.16 | 15.92 | 23 | 8318 | 26933 | 42586061 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Macular degeneration | 460.28 | 13.94 | 175 | 24254 | 21484 | 110543386 |
| Chronic sinusitis | 407.85 | 13.94 | 167 | 24262 | 24917 | 110539953 |
| Vaginal flatulence | 369.76 | 13.94 | 128 | 24301 | 12016 | 110552854 |
| Female genital tract fistula | 356.46 | 13.94 | 135 | 24294 | 16384 | 110548486 |
| Paraesthesia oral | 351.24 | 13.94 | 164 | 24265 | 33507 | 110531363 |
| Radiculopathy | 339.29 | 13.94 | 136 | 24293 | 19200 | 110545670 |
| Proctitis | 331.84 | 13.94 | 129 | 24300 | 16798 | 110548072 |
| Vaginal discharge | 324.79 | 13.94 | 129 | 24300 | 17779 | 110547091 |
| Procedural pain | 306.59 | 13.94 | 152 | 24277 | 35413 | 110529457 |
| Oral candidiasis | 235.99 | 13.94 | 138 | 24291 | 44622 | 110520248 |
| Dermatitis atopic | 193.32 | 13.94 | 100 | 24329 | 25441 | 110539429 |
| Colitis ulcerative | 184.62 | 13.94 | 146 | 24283 | 77217 | 110487653 |
| Colitis | 180.06 | 13.94 | 162 | 24267 | 102161 | 110462709 |
| Frequent bowel movements | 170.93 | 13.94 | 135 | 24294 | 71255 | 110493615 |
| Rectal haemorrhage | 145.75 | 13.94 | 155 | 24274 | 119678 | 110445192 |
| Therapeutic product effect incomplete | 142.26 | 13.94 | 209 | 24220 | 223596 | 110341274 |
| Erythema | 131.66 | 13.94 | 233 | 24196 | 291214 | 110273656 |
| Haematochezia | 129.25 | 13.94 | 143 | 24286 | 115381 | 110449489 |
| Weight decreased | 128.08 | 13.94 | 304 | 24125 | 467753 | 110097117 |
| Dyspepsia | 117.96 | 13.94 | 176 | 24253 | 190789 | 110374081 |
| Dry skin | 94.98 | 13.94 | 118 | 24311 | 107535 | 110457335 |
| Constipation | 71.68 | 13.94 | 207 | 24222 | 357579 | 110207291 |
| Toxicity to various agents | 63.97 | 13.94 | 14 | 24415 | 480541 | 110084329 |
| Anaemia | 56.63 | 13.94 | 255 | 24174 | 546831 | 110018039 |
| Skin exfoliation | 55.80 | 13.94 | 82 | 24347 | 87569 | 110477301 |
| Abdominal pain | 50.77 | 13.94 | 236 | 24193 | 512753 | 110052117 |
| Pruritus | 50.01 | 13.94 | 257 | 24172 | 581303 | 109983567 |
| Skin fissures | 49.56 | 13.94 | 42 | 24387 | 24416 | 110540454 |
| Eczema | 46.55 | 13.94 | 68 | 24361 | 72225 | 110492645 |
| Headache | 41.20 | 13.94 | 334 | 24095 | 882043 | 109682827 |
| Pain | 38.56 | 13.94 | 350 | 24079 | 954605 | 109610265 |
| Hepatic enzyme increased | 37.64 | 13.94 | 12 | 24417 | 320880 | 110243990 |
| General physical health deterioration | 37.30 | 13.94 | 24 | 24405 | 425271 | 110139599 |
| Staphylococcal infection | 36.89 | 13.94 | 60 | 24369 | 69884 | 110494986 |
| Systemic lupus erythematosus | 36.81 | 13.94 | 6 | 24423 | 254332 | 110310538 |
| Pyrexia | 36.65 | 13.94 | 330 | 24099 | 897935 | 109666935 |
| Malaise | 35.59 | 13.94 | 262 | 24167 | 671557 | 109893313 |
| Skin weeping | 35.26 | 13.94 | 17 | 24412 | 3718 | 110561152 |
| Hyperchlorhydria | 33.73 | 13.94 | 14 | 24415 | 2155 | 110562715 |
| Product dose omission issue | 33.23 | 13.94 | 150 | 24279 | 321632 | 110243238 |
| Nausea | 32.67 | 13.94 | 416 | 24013 | 1235274 | 109329596 |
| Lower respiratory tract infection | 32.48 | 13.94 | 7 | 24422 | 243099 | 110321771 |
| Injection site pain | 31.84 | 13.94 | 99 | 24330 | 177823 | 110387047 |
| Cellulitis | 31.30 | 13.94 | 79 | 24350 | 125937 | 110438933 |
| Drug interaction | 30.98 | 13.94 | 39 | 24390 | 500144 | 110064726 |
| Food aversion | 30.26 | 13.94 | 12 | 24417 | 1643 | 110563227 |
| Skin haemorrhage | 28.19 | 13.94 | 31 | 24398 | 24796 | 110540074 |
| Infusion related reaction | 27.69 | 13.94 | 161 | 24268 | 381001 | 110183869 |
| Confusional state | 27.53 | 13.94 | 38 | 24391 | 468642 | 110096228 |
| Fibromyalgia | 27.18 | 13.94 | 3 | 24426 | 170906 | 110393964 |
| Therapeutic product effect decreased | 27.15 | 13.94 | 10 | 24419 | 244306 | 110320564 |
| Folate deficiency | 26.90 | 13.94 | 15 | 24414 | 4423 | 110560447 |
| Humidity intolerance | 26.37 | 13.94 | 8 | 24421 | 492 | 110564378 |
| Tarsal tunnel syndrome | 25.64 | 13.94 | 8 | 24421 | 541 | 110564329 |
| Injection site swelling | 24.79 | 13.94 | 47 | 24382 | 61743 | 110503127 |
| Purpura senile | 24.74 | 13.94 | 8 | 24421 | 607 | 110564263 |
| Pain of skin | 24.48 | 13.94 | 26 | 24403 | 20003 | 110544867 |
| Body temperature abnormal | 23.02 | 13.94 | 12 | 24417 | 3097 | 110561773 |
| Autoimmune pericarditis | 21.70 | 13.94 | 5 | 24424 | 104 | 110564766 |
| Sleep disorder due to a general medical condition | 21.35 | 13.94 | 40 | 24389 | 52072 | 110512798 |
| Skin warm | 21.20 | 13.94 | 17 | 24412 | 9153 | 110555717 |
| Resorption bone increased | 20.86 | 13.94 | 9 | 24420 | 1525 | 110563345 |
| Neurodermatitis | 20.81 | 13.94 | 11 | 24418 | 2921 | 110561949 |
| Arthropathy | 20.44 | 13.94 | 20 | 24409 | 287502 | 110277368 |
| Contraindicated product administered | 20.43 | 13.94 | 15 | 24414 | 248252 | 110316618 |
| Skin infection | 20.36 | 13.94 | 25 | 24404 | 22484 | 110542386 |
| Scratch | 19.80 | 13.94 | 19 | 24410 | 12960 | 110551910 |
| Liver disorder | 19.19 | 13.94 | 4 | 24425 | 142239 | 110422631 |
| Intentional product use issue | 19.11 | 13.94 | 16 | 24413 | 247890 | 110316980 |
| Dermatitis | 19.11 | 13.94 | 27 | 24402 | 27810 | 110537060 |
| Treatment failure | 18.89 | 13.94 | 20 | 24409 | 277214 | 110287656 |
| Illness | 18.84 | 13.94 | 50 | 24379 | 82121 | 110482749 |
| Off label use | 18.74 | 13.94 | 448 | 23981 | 1499737 | 109065133 |
| Folliculitis | 18.39 | 13.94 | 7 | 24422 | 167646 | 110397224 |
| Ear pain | 18.35 | 13.94 | 38 | 24391 | 53188 | 110511682 |
| Drug intolerance | 18.33 | 13.94 | 39 | 24390 | 406473 | 110158397 |
| Appetite disorder | 18.22 | 13.94 | 16 | 24413 | 9753 | 110555117 |
| Product use in unapproved indication | 17.48 | 13.94 | 163 | 24266 | 447214 | 110117656 |
| Intentional overdose | 17.32 | 13.94 | 4 | 24425 | 132497 | 110432373 |
| Dysphoria | 17.21 | 13.94 | 13 | 24416 | 6415 | 110558455 |
| Bronchial oedema | 17.02 | 13.94 | 4 | 24425 | 91 | 110564779 |
| Skin discolouration | 16.89 | 13.94 | 35 | 24394 | 49011 | 110515859 |
| Dermatitis contact | 16.85 | 13.94 | 18 | 24411 | 13935 | 110550935 |
| Bursitis | 16.83 | 13.94 | 4 | 24425 | 129914 | 110434956 |
| Maternal exposure during pregnancy | 16.69 | 13.94 | 19 | 24410 | 254864 | 110310006 |
| Skin disorder | 16.42 | 13.94 | 32 | 24397 | 42881 | 110521989 |
| Hypersensitivity | 16.40 | 13.94 | 41 | 24388 | 403957 | 110160913 |
| Swelling | 16.39 | 13.94 | 33 | 24396 | 351008 | 110213862 |
| Mobility decreased | 16.32 | 13.94 | 17 | 24412 | 237405 | 110327465 |
| Hypertension | 16.22 | 13.94 | 58 | 24371 | 510026 | 110054844 |
| Surgery | 16.06 | 13.94 | 31 | 24398 | 41252 | 110523618 |
| Dry eye | 16.01 | 13.94 | 37 | 24392 | 55756 | 110509114 |
| Exposure via skin contact | 15.95 | 13.94 | 17 | 24412 | 13130 | 110551740 |
| Liver injury | 15.34 | 13.94 | 7 | 24422 | 150406 | 110414464 |
| Exposure during pregnancy | 15.28 | 13.94 | 9 | 24420 | 167415 | 110397455 |
| Sinus operation | 15.17 | 13.94 | 9 | 24420 | 2982 | 110561888 |
| Odynophagia | 14.97 | 13.94 | 17 | 24412 | 14084 | 110550786 |
| Irritable bowel syndrome | 14.75 | 13.94 | 9 | 24420 | 164206 | 110400664 |
| Overdose | 14.70 | 13.94 | 18 | 24411 | 233776 | 110331094 |
| Injection site erythema | 14.67 | 13.94 | 50 | 24379 | 94126 | 110470744 |
| Urine phosphorus increased | 14.64 | 13.94 | 4 | 24425 | 169 | 110564701 |
| Coma | 14.55 | 13.94 | 4 | 24425 | 117865 | 110447005 |
| Steroid withdrawal syndrome | 14.36 | 13.94 | 6 | 24423 | 939 | 110563931 |
| COVID-19 | 14.34 | 13.94 | 98 | 24331 | 244962 | 110319908 |
| Linear IgA disease | 14.31 | 13.94 | 10 | 24419 | 4379 | 110560491 |
| Delirium | 14.22 | 13.94 | 6 | 24423 | 135019 | 110429851 |
| Sleep disorder due to general medical condition, insomnia type | 14.19 | 13.94 | 3 | 24426 | 105640 | 110459230 |
| Cutaneous T-cell lymphoma | 14.14 | 13.94 | 9 | 24420 | 3375 | 110561495 |
| Therapeutic product effect delayed | 14.12 | 13.94 | 10 | 24419 | 4469 | 110560401 |
None
| Source | Code | Description |
|---|---|---|
| ATC | D06AX09 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use |
| ATC | R01AX06 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Other nasal preparations |
| FDA EPC | N0000175515 | RNA Synthetase Inhibitor Antibacterial |
| FDA MoA | N0000175516 | RNA Synthetase Inhibitors |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:48001 | protein synthesis inhibitor |
| CHEBI has role | CHEBI:76969 | bacterial metabolite |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:73336 | vulnerary |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Impetigo | indication | 48277006 | DOID:8504 |
| Staph Aureus Traumatic Skin Lesion Infection | indication | ||
| Methicillin-Resistant Staphylococcus Aureus Nasal Colonization | indication | ||
| Traumatic Skin Lesion Streptococcus Pyogenes Infection | indication | ||
| Folliculitis | off-label use | 13600006 | DOID:4409 |
| Atopic dermatitis | off-label use | 24079001 | DOID:3310 |
| Eczema | off-label use | 43116000 | |
| Epidermolysis bullosa | off-label use | 61003004 | DOID:2730 |
| Ecthyma | off-label use | 85791004 | |
| Furunculosis | off-label use | 112650006 | |
| Minor Bacterial Skin Infections | off-label use | ||
| Skin irritation | contraindication | 367466007 |
| Species | Use | Relation |
|---|---|---|
| Dogs | Bacterial infections of the skin caused by strains of Staphylococcus aureus | Indication |
| Dogs | Bacterial infections of the skin caused by Staphylococcus intermedius | Indication |
| Product | Applicant | Ingredients |
|---|---|---|
| Bactoderm Ointment | Zoetis Inc. | 1 |
| Muricin | Fougera Pharmaceuticals Inc. | 1 |
| Mupirocin Ointment USP, 2% | Taro Pharmaceuticals U.S.A. Inc. | 1 |
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.76 | acidic |
| pKa2 | 12.42 | acidic |
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Isoleucine--tRNA ligase, cytoplasmic | Enzyme | IC50 | 9.10 | CHEMBL | |||||
| Isoleucine--tRNA ligase | Enzyme | INHIBITOR | DRUGBANK | CHEMBL | |||||
| Isoleucine--tRNA ligase | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| Isoleucine--tRNA ligase | Enzyme | Ki | 8.60 | CHEMBL | |||||
| Isoleucine--tRNA ligase | Enzyme | Ki | 7.22 | CHEMBL | |||||
| Isoleucine--tRNA ligase, putative, EC 6.1.1.5 | Enzyme | IC50 | 7.24 | IUPHAR |
| ID | Source |
|---|---|
| 4019345 | VUID |
| N0000147519 | NUI |
| D01076 | KEGG_DRUG |
| 115074-43-6 | SECONDARY_CAS_RN |
| 4019345 | VANDF |
| 4021018 | VANDF |
| C0085259 | UMLSCUI |
| CHEBI:7025 | CHEBI |
| MRC | PDB_CHEM_ID |
| CHEMBL719 | ChEMBL_ID |
| CHEMBL3989715 | ChEMBL_ID |
| D016712 | MESH_DESCRIPTOR_UI |
| DB00410 | DRUGBANK_ID |
| 10916 | IUPHAR_LIGAND_ID |
| 5276 | INN_ID |
| D0GX863OA5 | UNII |
| 446596 | PUBCHEM_CID |
| 221128 | RXNORM |
| 198973 | MMSL |
| 47751 | MMSL |
| 5138 | MMSL |
| 5139 | MMSL |
| 720 | MMSL |
| 002802 | NDDF |
| 005869 | NDDF |
| 387397004 | SNOMEDCT_US |
| 441528009 | SNOMEDCT_US |
| 71453003 | SNOMEDCT_US |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-1010 | OINTMENT | 20 mg | TOPICAL | ANDA | 23 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1076 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |
| BACTROBAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-028 | CREAM | 20 mg | TOPICAL | NDA | 22 sections |
| MUPIROCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-158 | OINTMENT | 20 mg | TOPICAL | ANDA | 16 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-055 | CREAM | 20 mg | TOPICAL | ANDA | 28 sections |
| mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0112 | OINTMENT | 20 mg | TOPICAL | ANDA | 20 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-188 | OINTMENT | 20 mg | TOPICAL | ANDA | 19 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21922-029 | CREAM | 2 g | TOPICAL | ANDA | 23 sections |
| MUPIROCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21922-073 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |
| MUPIROCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21922-073 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-137 | OINTMENT | 20 mg | TOPICAL | ANDA | 19 sections |
| mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-229 | OINTMENT | 20 mg | TOPICAL | ANDA | 20 sections |
| mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-112 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45865-722 | OINTMENT | 20 mg | TOPICAL | ANDA | 20 sections |
| MUPIROCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 46708-624 | CREAM | 20 mg | TOPICAL | ANDA | 22 sections |
| mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1587 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |
| mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4349 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |
| mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4397 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-568 | OINTMENT | 20 mg | TOPICAL | ANDA | 25 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-0025 | OINTMENT | 20 mg | TOPICAL | ANDA | 23 sections |
| mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-0112 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-0180 | OINTMENT | 20 mg | TOPICAL | ANDA | 22 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-1010 | OINTMENT | 20 mg | TOPICAL | ANDA | 23 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1312 | OINTMENT | 20 mg | TOPICAL | ANDA | 25 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1370 | CREAM | 20 mg | TOPICAL | ANDA | 28 sections |
| mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-743 | OINTMENT | 20 mg | TOPICAL | ANDA | 20 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9850 | OINTMENT | 20 mg | TOPICAL | ANDA | 22 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9851 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |
| Mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9852 | OINTMENT | 20 mg | TOPICAL | ANDA | 23 sections |
| mupirocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9853 | OINTMENT | 20 mg | TOPICAL | ANDA | 24 sections |