azithromycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 276 83905-01-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CP-62993
  • CP 62993
  • azithromycin
  • arzomicin
  • aziromycin
  • Azithromycin A
  • azithromycin monohydrate
  • azithromycin anhydrous
  • azithromycin dihydrate
  • azithromycin hydrate
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis. Some evidence of in vitro activity against SARS-CoV-2 in infected Vero E6 and Caco-2 cells has been reported but clinical importance it is unclear. Only limited information available regarding the frequency and microbiology of bacterial pulmonary coinfections or superinfections in pacients with COVID-19.
  • Molecular weight: 749.00
  • Formula: C38H72N2O12
  • CLOGP: 2.64
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 5
  • TPSA: 180.08
  • ALOGS: -3.16
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.50 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.07 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 6 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 44.50 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 34 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 33 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.88 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 69 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.430 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 40.926 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.136 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.897 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 73.810 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 59.610 % High 1
herg hERG pIC50 3.970 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 0.893 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 5.957 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 80.900 % High 1
kinase-safety-class ACVR2B,AXL,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK7,NTRK2,PDK1,PDK4,PRKDC,TEK 16
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 2.046 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.729 High 1
mh-clint Mouse hepatocyte intrinsic clearance 1.824 High 1
mppb Mouse plasma protein binding (% unbound) 73.090 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.618 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 81.040 % High 1
rat-kpuu-brain Rat brain Kpuu 0.012 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.112 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 79.400 % High 1
rppb Rat plasma protein binding (% unbound) 74.390 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 868.960 uM High 1

Approvals:

DateAgencyCompanyOrphan
March 10, 2000 PMDA PFIZER
Nov. 1, 1991 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1129.71 9.54 2273 133157 461336 90031681
Infective pulmonary exacerbation of cystic fibrosis 829.43 9.54 372 135058 9907 90483110
Off label use 623.15 9.54 3261 132169 1098991 89394026
Abortion incomplete 555.32 9.54 200 135230 2940 90490077
Premature delivery 522.85 9.54 446 134984 38316 90454701
Macular degeneration 484.00 9.54 423 135007 37547 90455470
Nasal polyps 466.15 9.54 256 135174 10624 90482393
Pemphigus 466.10 9.54 4 135426 326860 90166157
Bronchiectasis 448.45 9.54 325 135105 22005 90471012
Hand deformity 411.76 9.54 6 135424 296356 90196661
Cough 410.82 9.54 1348 134082 367614 90125403
Synovitis 406.32 9.54 21 135409 329731 90163286
Contraindicated product administered 405.45 9.54 17 135413 320122 90172895
Normal labour 397.89 9.54 106 135324 511 90492506
Rhinitis allergic 368.63 9.54 258 135172 16527 90476490
Drug ineffective for unapproved indication 367.19 9.54 475 134955 66169 90426848
Glossodynia 365.61 9.54 31 135399 321748 90171269
Systemic lupus erythematosus 360.96 9.54 55 135375 361841 90131176
Electrocardiogram QT prolonged 354.06 9.54 487 134943 71969 90421048
Joint swelling 347.33 9.54 159 135271 503141 89989876
Asthma 336.88 9.54 957 134473 241203 90251814
Pericarditis 324.14 9.54 20 135410 270131 90222886
Delivery 320.05 9.54 115 135315 1678 90491339
Anti-cyclic citrullinated peptide antibody positive 315.45 9.54 8 135422 236425 90256592
Arthropathy 314.26 9.54 80 135350 366162 90126855
Cystic fibrosis 309.55 9.54 140 135290 3801 90489216
Helicobacter infection 309.20 9.54 6 135424 226844 90266173
Wound 274.10 9.54 59 135371 302921 90190096
Folliculitis 261.51 9.54 10 135420 204343 90288674
Alopecia 261.38 9.54 214 135216 494857 89998160
Chronic sinusitis 259.68 9.54 243 135187 23559 90469458
Abortion spontaneous 257.55 9.54 359 135071 53697 90439320
Asthma-chronic obstructive pulmonary disease overlap syndrome 257.13 9.54 132 135298 4767 90488250
Muscle injury 247.80 9.54 3 135427 176651 90316366
Total lung capacity increased 239.82 9.54 127 135303 4894 90488123
Rheumatoid factor positive 232.05 9.54 5 135425 171645 90321372
Sputum discoloured 231.78 9.54 213 135217 20178 90472839
Therapeutic product effect decreased 222.47 9.54 69 135361 277502 90215515
Productive cough 221.05 9.54 406 135024 76657 90416360
Chronic obstructive pulmonary disease 214.34 9.54 391 135039 73438 90419579
Pulmonary function test abnormal 214.17 9.54 97 135333 2642 90490375
Mobility decreased 210.72 9.54 57 135373 250677 90242340
Rheumatic fever 208.82 9.54 4 135426 153117 90339900
Impaired healing 204.97 9.54 49 135381 234150 90258867
Drug resistance 203.08 9.54 239 135191 30210 90462807
Swelling 199.76 9.54 199 135231 418859 90074158
Chest X-ray abnormal 194.35 9.54 111 135319 4971 90488046
Product use in unapproved indication 191.63 9.54 1000 134430 335236 90157781
Irritable bowel syndrome 190.42 9.54 39 135391 207409 90285608
Haemoptysis 181.13 9.54 236 135194 33084 90459933
Mycobacterium avium complex infection 179.89 9.54 98 135332 4000 90489017
Joint range of motion decreased 179.33 9.54 5 135425 135638 90357379
Arthralgia 177.45 9.54 585 134845 777937 89715080
Eosinophilia 177.22 9.54 216 135214 28317 90464700
Cholecystitis chronic 174.82 9.54 133 135297 9693 90483324
Full blood count abnormal 174.23 9.54 243 135187 36354 90456663
Type 2 diabetes mellitus 173.04 9.54 45 135385 203199 90289818
Upper-airway cough syndrome 171.82 9.54 158 135272 14977 90478040
Vaginal flatulence 171.55 9.54 146 135284 12492 90480525
Sarcoidosis 171.48 9.54 136 135294 10537 90482480
Sleep disorder due to general medical condition, insomnia type 169.19 9.54 5 135425 128689 90364328
Psoriatic arthropathy 167.06 9.54 66 135364 228269 90264748
Rheumatoid arthritis 165.09 9.54 179 135251 362435 90130582
Female genital tract fistula 162.28 9.54 165 135265 17703 90475314
Breath sounds abnormal 161.93 9.54 154 135276 15232 90477785
Wheezing 161.22 9.54 744 134686 237336 90255681
Obstructive airways disorder 160.93 9.54 196 135234 25673 90467344
Oral candidiasis 160.77 9.54 230 135200 35225 90457792
Abdominal discomfort 159.37 9.54 294 135136 477034 90015983
Completed suicide 159.22 9.54 16 135414 145042 90347975
Blister 157.20 9.54 93 135337 254905 90238112
Paraesthesia oral 154.89 9.54 213 135217 31446 90461571
Proctitis 153.55 9.54 149 135281 15110 90477907
Stomatitis 150.77 9.54 114 135316 274584 90218433
Fibromyalgia 148.64 9.54 61 135369 206208 90286809
Ear pruritus 145.71 9.54 103 135327 6700 90486317
Vaginal discharge 145.36 9.54 162 135268 19302 90473715
Rales 143.46 9.54 146 135284 15681 90477336
Hepatic enzyme increased 142.18 9.54 199 135231 360537 90132480
Radiculopathy 141.61 9.54 156 135274 18349 90474668
C-reactive protein abnormal 140.00 9.54 14 135416 127415 90365602
Dysphonia 138.25 9.54 297 135133 62787 90430230
Chest discomfort 138.12 9.54 488 134942 137877 90355140
Blood lactic acid increased 137.07 9.54 110 135320 8668 90484349
Confusional state 135.98 9.54 230 135200 385975 90107042
Hypoxia 134.29 9.54 319 135111 72080 90420937
Peripheral swelling 133.84 9.54 259 135171 412847 90080170
Haemorrhage 133.41 9.54 310 135120 69059 90423958
Cardiac murmur 130.02 9.54 148 135282 18046 90474971
Discomfort 127.52 9.54 133 135297 274202 90218815
Pathogen resistance 127.37 9.54 102 135328 8013 90485004
Procedural pain 122.27 9.54 196 135234 33164 90459853
Gait inability 121.67 9.54 34 135396 146422 90346595
Cholelithiasis 120.61 9.54 252 135178 52254 90440763
Emotional distress 119.07 9.54 204 135226 36458 90456559
Liver injury 118.80 9.54 53 135377 170514 90322503
Blood cholesterol increased 118.44 9.54 83 135347 207929 90285088
Ototoxicity 118.01 9.54 58 135372 1906 90491111
Product packaging quantity issue 116.67 9.54 54 135376 1548 90491469
Treatment failure 115.46 9.54 172 135258 303756 90189261
Infusion related reaction 113.10 9.54 288 135142 416492 90076525
Lung opacity 111.66 9.54 84 135346 6018 90486999
Dyspnoea 110.81 9.54 1889 133541 879066 89613951
Pulmonary function test decreased 110.31 9.54 74 135356 4420 90488597
Pneumonia 109.71 9.54 1444 133986 636615 89856402
Wound infection 108.67 9.54 15 135415 106387 90386630
Total lung capacity decreased 106.61 9.54 68 135362 3727 90489290
Deafness 106.42 9.54 149 135281 22365 90470652
Jaundice cholestatic 104.70 9.54 100 135330 9943 90483074
Bronchopulmonary aspergillosis allergic 104.60 9.54 67 135363 3699 90489318
Impaired quality of life 101.79 9.54 148 135282 22996 90470021
Prescribed overdose 101.52 9.54 13 135417 97612 90395405
Swollen tongue 101.42 9.54 217 135213 45739 90447278
Lip dry 101.31 9.54 15 135415 100940 90392077
Torsade de pointes 99.29 9.54 118 135312 15064 90477953
Product use issue 99.04 9.54 216 135214 329703 90163314
Ill-defined disorder 98.53 9.54 79 135351 184812 90308205
Grip strength decreased 97.06 9.54 12 135418 92564 90400453
Bursitis 96.35 9.54 38 135392 131616 90361401
Hypoaesthesia 95.74 9.54 204 135226 314006 90179011
Nasal congestion 94.49 9.54 307 135123 83107 90409910
No adverse event 93.67 9.54 268 135162 67714 90425303
Swelling face 93.59 9.54 301 135129 81051 90411966
Peripheral venous disease 92.75 9.54 9 135421 83912 90409105
Exposure during pregnancy 92.06 9.54 641 134789 237769 90255248
Drug interaction 91.22 9.54 716 134714 275737 90217280
Long QT syndrome 90.84 9.54 63 135367 3974 90489043
Musculoskeletal stiffness 89.94 9.54 193 135237 296339 90196678
Sleep disorder 89.77 9.54 98 135332 197932 90295085
Hypomania 89.75 9.54 87 135343 8810 90484207
Respiratory failure 89.07 9.54 382 135048 118036 90374981
Tinnitus 88.83 9.54 198 135232 42904 90450113
Platelet count increased 88.29 9.54 131 135299 20728 90472289
Bronchitis 84.99 9.54 452 134978 152475 90340542
Hypercholesterolaemia 84.58 9.54 23 135407 100869 90392148
General physical health deterioration 84.02 9.54 262 135168 354853 90138164
Osteoarthritis 83.17 9.54 102 135328 195628 90297389
Infective exacerbation of bronchiectasis 79.36 9.54 29 135401 445 90492572
Transaminases increased 76.81 9.54 171 135259 37021 90455996
Hypertension 76.79 9.54 387 135043 457145 90035872
Biliary dyskinesia 76.58 9.54 48 135382 2551 90490466
Upper respiratory tract infection 75.95 9.54 386 135044 127932 90365085
Lung neoplasm malignant 74.82 9.54 132 135298 24141 90468876
Angioedema 74.58 9.54 240 135190 64636 90428381
Mycobacterium abscessus infection 74.46 9.54 35 135395 1040 90491977
Lower limb fracture 73.91 9.54 18 135412 84995 90408022
Pneumatosis intestinalis 73.52 9.54 52 135378 3385 90489632
Intentional product use issue 72.78 9.54 133 135297 216759 90276258
Rhinorrhoea 72.76 9.54 293 135137 88023 90404994
Pulmonary embolism 72.23 9.54 386 135044 130434 90362583
Sleep disorder due to a general medical condition 71.23 9.54 186 135244 44552 90448465
Prescribed underdose 71.13 9.54 13 135417 75006 90418011
Lip oedema 70.03 9.54 57 135373 4582 90488435
Eye pruritus 69.81 9.54 142 135288 28885 90464132
Bronchial wall thickening 69.52 9.54 42 135388 2089 90490928
Fatigue 68.63 9.54 1264 134166 1152759 89340258
Hip arthroplasty 68.51 9.54 15 135415 76193 90416824
Vasculitis 68.13 9.54 122 135308 22571 90470446
Maternal exposure during pregnancy 67.28 9.54 828 134602 359235 90133782
Autoimmune disorder 67.21 9.54 16 135414 76728 90416289
Inflammation 66.87 9.54 102 135328 178490 90314527
Bone erosion 66.43 9.54 3 135427 53018 90439999
Knee arthroplasty 66 9.54 21 135409 83161 90409856
Drug ineffective 65.99 9.54 2608 132822 1381690 89111327
Stevens-Johnson syndrome 65.14 9.54 139 135291 29237 90463780
Epilepsy 64.79 9.54 21 135409 82185 90410832
Muscular weakness 64.75 9.54 132 135298 206534 90286483
Malignant neoplasm progression 64.38 9.54 40 135390 106830 90386187
Liver disorder 63.12 9.54 53 135377 121216 90371801
Mycobacterial infection 63.08 9.54 40 135390 2170 90490847
Product dose omission issue 63.05 9.54 690 134740 290997 90202020
Hepatotoxicity 62.44 9.54 180 135250 45662 90447355
Low birth weight baby 60.95 9.54 73 135357 9394 90483623
Cystic fibrosis respiratory infection suppression 60.48 9.54 22 135408 333 90492684
Weight increased 60.03 9.54 372 135058 417555 90075462
Lacrimation increased 59.95 9.54 128 135302 26934 90466083
Contusion 59.62 9.54 185 135245 251031 90241986
Intentional overdose 59.52 9.54 33 135397 93801 90399216
Dry mouth 58.99 9.54 116 135314 183943 90309074
Abdominal pain 58.31 9.54 872 134558 394849 90098168
Schizophrenia 56.54 9.54 89 135341 14825 90478192
Pneumomediastinum 56.08 9.54 36 135394 1995 90491022
Road traffic accident 56.06 9.54 47 135383 107579 90385438
C-reactive protein increased 55.85 9.54 117 135313 181272 90311745
Adverse event 55.56 9.54 56 135374 117362 90375655
Acute generalised exanthematous pustulosis 55.06 9.54 84 135346 13619 90479398
Prolonged expiration 55.01 9.54 30 135400 1227 90491790
Factor V inhibition 54.62 9.54 17 135413 154 90492863
Toxicity to various agents 54.44 9.54 233 135197 287613 90205404
Sciatica 54.39 9.54 43 135387 101339 90391678
Nail disorder 54.38 9.54 11 135419 59056 90433961
Oedema 53.79 9.54 139 135291 200156 90292861
Frequent bowel movements 53.53 9.54 197 135233 56738 90436279
Gastrointestinal disorder 53.46 9.54 200 135230 256487 90236530
Gallbladder disorder 52.60 9.54 101 135329 19702 90473315
Sneezing 52.57 9.54 129 135301 29740 90463277
Respiration abnormal 52.25 9.54 62 135368 7901 90485116
Colitis 52.09 9.54 225 135205 69717 90423300
Heart sounds 52 9.54 28 135402 1116 90491901
Haematochezia 51.95 9.54 227 135203 70686 90422331
Flank pain 51.01 9.54 98 135332 19124 90473893
Hallucinations, mixed 50.97 9.54 53 135377 5836 90487181
Onychomadesis 50.65 9.54 5 135425 45993 90447024
Chronic kidney disease 50.02 9.54 177 135253 50014 90443003
Pseudomonas infection 49.96 9.54 84 135346 14781 90478236
Forced expiratory volume decreased 49.78 9.54 52 135378 5756 90487261
Lupus-like syndrome 49.60 9.54 7 135423 48839 90444178
Ventilation perfusion mismatch 49.59 9.54 22 135408 570 90492447
Acute respiratory distress syndrome 49.54 9.54 123 135307 28563 90464454
Eosinophil count increased 49.50 9.54 78 135352 13003 90480014
Fall 48.91 9.54 472 134958 481338 90011679
Influenza 48.84 9.54 366 135064 138898 90354119
Bronchopulmonary aspergillosis 48.84 9.54 72 135358 11326 90481691
Drug abuse 47.99 9.54 32 135398 82315 90410702
Oropharyngeal pain 46.96 9.54 314 135116 114873 90378144
Disseminated mycobacterium avium complex infection 46.88 9.54 17 135413 255 90492762
Premature baby 45.95 9.54 110 135320 24967 90468050
Musculoskeletal pain 45.86 9.54 119 135311 171132 90321885
Hepatic cytolysis 45.64 9.54 125 135305 30791 90462226
Respiratory tract infection 45.50 9.54 192 135238 58886 90434131
Atypical mycobacterial infection 45.34 9.54 29 135401 1597 90491420
Toxic epidermal necrolysis 44.57 9.54 128 135302 32400 90460617
Gait disturbance 44.41 9.54 219 135211 260277 90232740
Death 44.35 9.54 452 134978 456099 90036918
Colitis ulcerative 44.21 9.54 193 135237 60073 90432944
Dysbiosis 44.13 9.54 29 135401 1673 90491344
Erythema 43.99 9.54 530 134900 228716 90264301
Pneumonia bacterial 43.95 9.54 73 135357 12717 90480300
Blood bilirubin increased 43.92 9.54 154 135276 43316 90449701
Blood potassium decreased 43.91 9.54 164 135266 47563 90445454
Therapeutic product effect incomplete 43.88 9.54 463 134967 193433 90299584
Alveolitis 43.26 9.54 36 135394 2985 90490032
Night sweats 43.14 9.54 79 135351 128687 90364330
Overdose 42.68 9.54 109 135321 157600 90335417
Deafness neurosensory 41.20 9.54 51 135379 6790 90486227
Pneumothorax 40.56 9.54 89 135341 19078 90473939
Pleuritic pain 40.45 9.54 63 135367 10398 90482619
Pelvic inflammatory disease 39.87 9.54 28 135402 1802 90491215
Drug reaction with eosinophilia and systemic symptoms 39.40 9.54 147 135283 42611 90450406
Foot deformity 39.27 9.54 20 135410 59631 90433386
Ventricular fibrillation 39.00 9.54 73 135357 13971 90479046
Agranulocytosis 38.88 9.54 128 135302 34874 90458143
Taste disorder 38.52 9.54 22 135408 61524 90431493
Pulmonary mass 38.24 9.54 112 135318 28660 90464357
Rash maculo-papular 37.11 9.54 140 135290 40793 90452224
Adverse drug reaction 36.99 9.54 74 135356 116627 90376390
Cardiac arrest 36.90 9.54 276 135154 104659 90388358
Blood calcium increased 36.42 9.54 65 135365 11993 90481024
Anosmia 36.27 9.54 58 135372 9790 90483227
Aspergillus infection 36.16 9.54 61 135369 10762 90482255
Bronchial secretion retention 35.81 9.54 35 135395 3580 90489437
COVID-19 35.80 9.54 398 135032 168445 90324572
Sputum increased 35.78 9.54 32 135398 2925 90490092
Underdose 35.72 9.54 18 135412 53999 90439018
Pain in extremity 35.58 9.54 467 134963 450062 90042955
Eosinophilic pneumonia 35.53 9.54 31 135399 2742 90490275
Staphylococcal infection 35.43 9.54 155 135275 48284 90444733
Rectal haemorrhage 35.20 9.54 228 135202 82516 90410501
Aspiration 34.50 9.54 74 135356 15619 90477398
Pneumothorax spontaneous 34.43 9.54 20 135410 925 90492092
Acute respiratory failure 34.23 9.54 141 135289 42777 90450240
Pneumococcal infection 34.21 9.54 22 135408 1223 90491794
Drug tolerance decreased 34.08 9.54 4 135426 32126 90460891
Walking aid user 33.99 9.54 6 135424 35500 90457517
Cystic fibrosis pancreatic 33.51 9.54 9 135421 45 90492972
Sedation 33.47 9.54 15 135415 48156 90444861
Gastrooesophageal reflux disease 33.41 9.54 388 135042 165949 90327068
Exostosis 33.24 9.54 19 135411 53115 90439902
Auscultation 33.05 9.54 6 135424 0 90493017
Psychotic disorder 32.73 9.54 112 135318 31118 90461899
Lung transplant rejection 32.63 9.54 20 135410 1021 90491996
Bacterial disease carrier 32.63 9.54 25 135405 1841 90491176
Thermal burn 32.32 9.54 45 135385 6717 90486300
Viral infection 32.20 9.54 135 135295 41279 90451738
Symmetrical drug-related intertriginous and flexural exanthema 31.18 9.54 19 135411 960 90492057
Photodermatosis 31.13 9.54 16 135414 579 90492438
Hypoacusis 31.07 9.54 102 135328 27748 90465269
Amnesia 30.92 9.54 73 135357 108432 90384585
Congenital absence of cranial vault 30.88 9.54 7 135423 14 90493003
Ear discomfort 30.83 9.54 55 135375 10145 90482872
Paranasal sinus discomfort 30.70 9.54 42 135388 6168 90486849
Pyrexia 30.67 9.54 1242 134188 659243 89833774
Middle lobe syndrome 30.66 9.54 8 135422 35 90492982
Blood test abnormal 30.22 9.54 84 135346 20868 90472149
Actinic keratosis 29.97 9.54 30 135400 3158 90489859
Bronchial anastomosis complication 29.37 9.54 9 135421 77 90492940
Atypical mycobacterium test positive 29.13 9.54 7 135423 20 90492997
Sinobronchitis 28.67 9.54 16 135414 685 90492332
Gallbladder injury 28.49 9.54 20 135410 1286 90491731
Eosinophilic pneumonia acute 28.37 9.54 16 135414 699 90492318
Bacterial infection 28.10 9.54 88 135342 23356 90469661
Migraine 28.06 9.54 168 135262 190224 90302793
Deep vein thrombosis 27.83 9.54 233 135197 91387 90401630
Lower respiratory tract infection 27.80 9.54 240 135190 250419 90242598
Arthritis 27.73 9.54 142 135288 167173 90325844
Kounis syndrome 27.72 9.54 26 135404 2527 90490490
Pulmonary cavitation 27.47 9.54 18 135412 1033 90491984
Increased bronchial secretion 27.45 9.54 24 135406 2129 90490888
Myasthenia gravis crisis 27.27 9.54 18 135412 1046 90491971
Distal intestinal obstruction syndrome 27.18 9.54 14 135416 509 90492508
Platelet count decreased 27.03 9.54 109 135321 136860 90356157
Organising pneumonia 26.97 9.54 44 135386 7553 90485464
Mixed liver injury 26.85 9.54 44 135386 7579 90485438
Delirium 26.81 9.54 74 135356 104285 90388732
Finger deformity 26.64 9.54 8 135422 32889 90460128
Device expulsion 26.48 9.54 14 135416 40872 90452145
Cholestasis 26.43 9.54 116 135314 36183 90456834
Anhedonia 26.40 9.54 55 135375 11376 90481641
Illness 26.27 9.54 211 135219 81758 90411259
Sinus polyp degeneration 26.26 9.54 8 135422 67 90492950
Ulcer haemorrhage 26.19 9.54 4 135426 26317 90466700
Muscle spasticity 26.15 9.54 10 135420 35312 90457705
Deafness bilateral 25.76 9.54 21 135409 1692 90491325
Ageusia 25.75 9.54 67 135363 16009 90477008
Tachypnoea 25.55 9.54 80 135350 21229 90471788
Onychomycosis 25.41 9.54 12 135418 37364 90455653
Factor V deficiency 25.27 9.54 8 135422 77 90492940
Emphysema 25.22 9.54 56 135374 12099 90480918
Gastroenteritis staphylococcal 25.18 9.54 8 135422 78 90492939
Coeliac disease 25.10 9.54 18 135412 44592 90448425
Joint dislocation 25.07 9.54 18 135412 44564 90448453
Amniotic cavity infection 25.06 9.54 19 135411 1377 90491640
Memory impairment 25.05 9.54 182 135248 197062 90295955
Back injury 24.72 9.54 20 135410 46602 90446415
Aphthous ulcer 24.63 9.54 69 135361 17218 90475799
Suicide attempt 24.59 9.54 47 135383 75352 90417665
Foetal exposure during pregnancy 24.52 9.54 128 135302 42847 90450170
Neutropenia 24.21 9.54 217 135213 224687 90268330
Staphylococcus test positive 23.96 9.54 31 135399 4314 90488703
Rhinocerebral mucormycosis 23.93 9.54 15 135415 797 90492220
Myelosuppression 23.74 9.54 27 135403 53564 90439453
Granulomatosis with polyangiitis 23.70 9.54 24 135406 2561 90490456
Dehiscence 23.68 9.54 9 135421 155 90492862
Ecchymosis 23.60 9.54 55 135375 12268 90480749
Appetite disorder 23.54 9.54 46 135384 9087 90483930
Hilar lymphadenopathy 23.44 9.54 18 135412 1330 90491687
Wound complication 23.22 9.54 32 135398 4731 90488286
Psoriasis 23.04 9.54 128 135302 147626 90345391
Somnolence 22.82 9.54 201 135229 208883 90284134
Therapeutic response decreased 22.77 9.54 64 135366 89665 90403352
Immune reconstitution inflammatory syndrome 22.71 9.54 39 135391 6980 90486037
Joint stiffness 22.64 9.54 52 135378 77990 90415027
Mechanical urticaria 22.58 9.54 13 135417 591 90492426
Injection site reaction 22.40 9.54 67 135363 92013 90401004
Acute kidney injury 22.34 9.54 632 134798 319755 90173262
Immunosuppressant drug level increased 22.16 9.54 31 135399 4649 90488368
Hepatic cirrhosis 21.91 9.54 38 135392 63215 90429802
Hypokalaemia 21.88 9.54 111 135319 131005 90362012
Weight decreased 21.86 9.54 732 134698 379178 90113839
Gallbladder cholesterolosis 21.84 9.54 14 135416 774 90492243
Dyspnoea exertional 21.51 9.54 183 135247 72105 90420912
Cystic fibrosis lung 21.47 9.54 8 135422 130 90492887
Mucosal inflammation 21.47 9.54 33 135397 57592 90435425
Neutrophil count decreased 21.29 9.54 47 135383 71485 90421532
Ventricular tachycardia 21.16 9.54 83 135347 24625 90468392
Febrile neutropenia 21.14 9.54 144 135286 158205 90334812
Pneumonia pseudomonal 21.12 9.54 25 135405 3178 90489839
Stillbirth 21.06 9.54 39 135391 7404 90485613
Solar lentigo 21.05 9.54 16 135414 1164 90491853
Upper airway necrosis 21.01 9.54 6 135424 39 90492978
Tracheobronchitis 20.88 9.54 18 135412 1567 90491450
Respiratory distress 20.86 9.54 114 135316 38832 90454185
Pneumonitis 20.84 9.54 125 135305 44045 90448972
Endometritis 20.81 9.54 16 135414 1184 90491833
Lung infiltration 20.80 9.54 60 135370 15222 90477795
Bronchomalacia 20.77 9.54 9 135421 220 90492797
Hepatitis cholestatic 20.72 9.54 42 135388 8519 90484498
Depressive symptom 20.67 9.54 32 135398 5253 90487764
COVID-19 pneumonia 20.66 9.54 67 135363 18110 90474907
Uterine perforation 20.64 9.54 39 135391 7515 90485502
Coma 20.58 9.54 49 135381 72583 90420434
Stenotrophomonas infection 20.53 9.54 22 135408 2507 90490510
Henoch-Schonlein purpura 20.47 9.54 18 135412 1609 90491408
Hyperbilirubinaemia 20.22 9.54 56 135374 13880 90479137
Rheumatoid nodule 20.22 9.54 3 135427 20163 90472854
Laryngitis 19.95 9.54 28 135402 50725 90442292
Cholinergic rebound syndrome 19.94 9.54 5 135425 18 90492999
Decreased appetite 19.92 9.54 420 135010 376120 90116897
Bronchial obstruction 19.89 9.54 18 135412 1671 90491346
Viral labyrinthitis 19.80 9.54 4 135426 3 90493014
Pulmonary infarction 19.78 9.54 23 135407 2869 90490148
Pancreatic failure 19.76 9.54 17 135413 1475 90491542
Peak expiratory flow rate abnormal 19.49 9.54 7 135423 102 90492915
Biliary colic 19.36 9.54 27 135403 4036 90488981
Mycobacterium test positive 19.32 9.54 9 135421 262 90492755
Middle insomnia 19.27 9.54 62 135368 16689 90476328
Blood creatinine increased 19.25 9.54 234 135196 101152 90391865
Eye irritation 19.24 9.54 101 135329 33877 90459140
Pneumonia necrotising 19.19 9.54 12 135418 635 90492382
Intentional product misuse 19.17 9.54 69 135361 89535 90403482
Rheumatoid factor 19.05 9.54 11 135419 503 90492514
Live birth 18.93 9.54 58 135372 79049 90413968
Choroiditis 18.91 9.54 9 135421 275 90492742
Medication error 18.91 9.54 64 135366 84588 90408429
Breast cancer 18.89 9.54 32 135398 53729 90439288
Cystic fibrosis related diabetes 18.84 9.54 6 135424 59 90492958
Red blood cell sedimentation rate increased 18.75 9.54 62 135368 82533 90410484
Seasonal allergy 18.72 9.54 76 135354 22907 90470110
Altered state of consciousness 18.71 9.54 12 135418 31520 90461497
Foetal heart rate deceleration abnormality 18.66 9.54 12 135418 667 90492350
Orthostatic hypotension 18.61 9.54 21 135409 41806 90451211
Autoimmune hepatitis 18.53 9.54 45 135385 10306 90482711
Pharyngeal erythema 18.39 9.54 18 135412 1844 90491173
Multiple allergies 18.28 9.54 57 135373 15089 90477928
Insomnia 17.92 9.54 371 135059 333103 90159914
Incorrect route of product administration 17.91 9.54 30 135400 50596 90442421
Hypoxic-ischaemic encephalopathy 17.89 9.54 28 135402 4640 90488377
Dysentery 17.84 9.54 14 135416 1068 90491949
Rhinovirus infection 17.82 9.54 32 135398 5931 90487086
Dizziness 17.82 9.54 710 134720 588574 89904443
Delusional disorder, persecutory type 17.61 9.54 9 135421 322 90492695
Eosinophilic pneumonia chronic 17.49 9.54 8 135422 223 90492794
Fluid retention 17.44 9.54 70 135360 88021 90404996
Hypersensitivity 17.38 9.54 532 134898 454145 90038872
Maternal exposure timing unspecified 17.26 9.54 6 135424 22477 90470540
Obesity 17.22 9.54 90 135340 105417 90387600
Laryngeal mass 16.84 9.54 5 135425 38 90492979
Pigment nephropathy 16.84 9.54 5 135425 38 90492979
Spinal cord compression 16.83 9.54 28 135402 4883 90488134
Fracture 16.77 9.54 6 135424 22070 90470947
Mucocutaneous candidiasis 16.76 9.54 4 135426 11 90493006
Adverse event following immunisation 16.52 9.54 3 135427 0 90493017
Portal hypertensive enteropathy 16.52 9.54 3 135427 0 90493017
Allergic sinusitis 16.49 9.54 18 135412 2095 90490922
Gingival oedema 16.48 9.54 6 135424 91 90492926
Anaemia 16.45 9.54 664 134766 352138 90140879
Hypercapnia 16.45 9.54 33 135397 6644 90486373
Sputum retention 16.43 9.54 11 135419 655 90492362
Vaginal stricture 16.26 9.54 4 135426 13 90493004
Obliterative bronchiolitis 16.16 9.54 20 135410 2661 90490356
Vaginal cellulitis 16.08 9.54 6 135424 98 90492919
Meningism 16.06 9.54 10 135420 525 90492492
Rhonchi 16.03 9.54 21 135409 2957 90490060
Cryptococcosis 16.01 9.54 15 135415 1456 90491561
Hemianopia heteronymous 16.00 9.54 5 135425 46 90492971
Gastrointestinal haemorrhage 15.87 9.54 75 135355 90173 90402844
Drug intolerance 15.84 9.54 529 134901 447062 90045955
Ocular toxicity 15.77 9.54 13 135417 1064 90491953
Pulmonary fibrosis 15.76 9.54 95 135335 107408 90385609
Mycoplasma infection 15.63 9.54 12 135418 886 90492131
Hyperkeratosis 15.61 9.54 33 135397 6895 90486122
Nasal discomfort 15.61 9.54 29 135401 5519 90487498
Depressed level of consciousness 15.60 9.54 56 135374 72728 90420289
White blood cell count decreased 15.55 9.54 167 135263 166942 90326075
Nasal dryness 15.48 9.54 29 135401 5554 90487463
Sinus disorder 15.31 9.54 96 135334 34351 90458666
Immunodeficiency common variable 15.24 9.54 9 135421 429 90492588
Nocardiosis 15.22 9.54 19 135411 2551 90490466
Infusion site streaking 15.21 9.54 10 135420 577 90492440
Respiratory tract congestion 15.20 9.54 81 135349 27329 90465688
Sinus congestion 15.18 9.54 81 135349 27343 90465674
Drug tolerance 15.17 9.54 4 135426 17912 90475105
Pharyngeal enanthema 15.11 9.54 5 135425 56 90492961
Neural tube defect 15.11 9.54 7 135423 201 90492816
Vulvovaginal burning sensation 15.07 9.54 19 135411 2576 90490441
Human ehrlichiosis 15.05 9.54 7 135423 203 90492814
Hypofibrinogenaemia 14.96 9.54 14 135416 1356 90491661
Diabetic ketoacidosis 14.88 9.54 9 135421 24398 90468619
Drug effective for unapproved indication 14.79 9.54 35 135395 7883 90485134
Myasthenia gravis 14.79 9.54 32 135398 6793 90486224
Nausea 14.77 9.54 1884 133546 1108432 89384585
Post polio syndrome 14.73 9.54 4 135426 21 90492996
Respiratory tract inflammation 14.72 9.54 10 135420 610 90492407
Hypotension 14.67 9.54 372 135058 325025 90167992
Local reaction 14.66 9.54 11 135419 785 90492232
Neck pain 14.54 9.54 105 135325 113858 90379159
Iris transillumination defect 14.47 9.54 6 135424 131 90492886
Kawasaki's disease 14.45 9.54 3 135427 3 90493014
Bone density decreased 14.45 9.54 4 135426 17341 90475676
Paranasal sinus inflammation 14.44 9.54 10 135420 629 90492388
Cholecystitis 14.40 9.54 57 135373 16983 90476034
Autoimmune thyroiditis 14.37 9.54 29 135401 5864 90487153
Leukaemoid reaction 14.36 9.54 7 135423 226 90492791
Hepatocellular injury 14.34 9.54 83 135347 28875 90464142
Atypical mycobacterial lower respiratory tract infection 14.33 9.54 7 135423 227 90492790
Crystal arthropathy 14.32 9.54 8 135422 343 90492674
HIV infection 14.30 9.54 9 135421 482 90492535
Scedosporium infection 14.30 9.54 11 135419 815 90492202
Uvulitis 14.28 9.54 4 135426 24 90492993
Pustular psoriasis 14.17 9.54 5 135425 18551 90474466
Rebound acid hypersecretion 14.13 9.54 8 135422 352 90492665
Blood viscosity abnormal 14.13 9.54 7 135423 234 90492783
Procedural anxiety 13.95 9.54 11 135419 845 90492172
Lung neoplasm 13.94 9.54 31 135399 6704 90486313
Rhinalgia 13.94 9.54 18 135412 2500 90490517
Tremor 13.87 9.54 313 135117 152860 90340157
Condition aggravated 13.86 9.54 1051 134379 594494 89898523
Traumatic haemothorax 13.86 9.54 7 135423 244 90492773
Cognitive disorder 13.84 9.54 55 135375 69352 90423665
Sopor 13.79 9.54 10 135420 24634 90468383
Erythema multiforme 13.79 9.54 45 135385 12201 90480816
Lymph node abscess 13.75 9.54 4 135426 28 90492989
Sinus pain 13.72 9.54 27 135403 5362 90487655
Epidermolysis 13.51 9.54 10 135420 699 90492318
Pain 13.49 9.54 1294 134136 995047 89497970
Pancreatitis acute 13.35 9.54 88 135342 32027 90460990
Good syndrome 13.24 9.54 3 135427 6 90493011
Sputum purulent 13.22 9.54 13 135417 1339 90491678
Optic neuritis 13.17 9.54 38 135392 9640 90483377
Brain hypoxia 13.09 9.54 9 135421 560 90492457
Veillonella infection 13.08 9.54 4 135426 34 90492983
Dysarthria 12.99 9.54 40 135390 54442 90438575
Humidity intolerance 12.99 9.54 8 135422 412 90492605
Catastrophic reaction 12.97 9.54 4 135426 35 90492982
Pneumonia aspiration 12.94 9.54 26 135404 40914 90452103
Therapy interrupted 12.93 9.54 123 135307 49985 90443032
Injection site erythema 12.93 9.54 90 135340 98412 90394605
Urethral stenosis 12.93 9.54 7 135423 282 90492735
Acute sinusitis 12.91 9.54 23 135407 4238 90488779
Pharyngitis streptococcal 12.75 9.54 45 135385 12697 90480320
Oesophagogastroduodenoscopy 12.74 9.54 6 135424 179 90492838
Nosocomial infection 12.73 9.54 15 135415 1898 90491119
Jarisch-Herxheimer reaction 12.72 9.54 8 135422 428 90492589
Vulvovaginal pruritus 12.67 9.54 22 135408 3971 90489046
Tympanic membrane hyperaemia 12.64 9.54 3 135427 8 90493009
Neoplasm progression 12.61 9.54 30 135400 44456 90448561
Lung transplant 12.59 9.54 21 135409 3671 90489346
Pharyngeal swelling 12.54 9.54 38 135392 9906 90483111
Deafness unilateral 12.53 9.54 20 135410 3371 90489646
Corneal perforation 12.48 9.54 9 135421 604 90492413
Terminal insomnia 12.48 9.54 12 135418 1203 90491814
Joint effusion 12.40 9.54 7 135423 19703 90473314
Infant irritability 12.38 9.54 3 135427 9 90493008
Blastomycosis 12.31 9.54 8 135422 453 90492564
Biopsy colon abnormal 12.28 9.54 5 135425 104 90492913
Jaundice 12.27 9.54 87 135343 32430 90460587
Metastases to bone 12.25 9.54 12 135418 25493 90467524
Metastases to liver 12.24 9.54 15 135415 28792 90464225
Osteonecrosis of jaw 12.21 9.54 25 135405 39078 90453939
Dermatosis 12.20 9.54 9 135421 626 90492391
Fungal infection 12.17 9.54 107 135323 42554 90450463
Oxygen saturation decreased 12.16 9.54 227 135203 107256 90385761
Mucosal dryness 12.14 9.54 19 135411 3148 90489869
Balance disorder 12.12 9.54 90 135340 96990 90396027
Lung diffusion test decreased 12.10 9.54 10 135420 821 90492196
Cardiac failure 12.06 9.54 105 135325 109391 90383626
Myopathy 12.06 9.54 46 135384 13472 90479545
Pulmonary tuberculosis 12.04 9.54 24 135406 4810 90488207
Clostridium difficile infection 11.99 9.54 94 135336 36151 90456866
Neisseria infection 11.94 9.54 5 135425 112 90492905
Blood immunoglobulin G decreased 11.90 9.54 20 135410 3518 90489499
Gallbladder hypofunction 11.83 9.54 8 135422 484 90492533
Hypogammaglobulinaemia 11.82 9.54 39 135391 10635 90482382
Stomatococcal infection 11.74 9.54 5 135425 117 90492900
Pulmonary alveolar haemorrhage 11.74 9.54 27 135403 5971 90487046
Hepato-lenticular degeneration 11.71 9.54 3 135427 12 90493005
Bronchogram abnormal 11.71 9.54 3 135427 12 90493005
Hospitalisation 11.67 9.54 262 135168 127838 90365179
Hypoventilation 11.67 9.54 25 135405 5271 90487746
Monoclonal gammopathy 11.65 9.54 10 135420 865 90492152
Anal skin tags 11.65 9.54 9 135421 671 90492346
Cerebral venous sinus thrombosis 11.64 9.54 16 135414 2360 90490657
Infusion site reaction 11.64 9.54 7 135423 19032 90473985
COVID-19 treatment 11.62 9.54 5 135425 120 90492897
Hypersensitivity pneumonitis 11.56 9.54 21 135409 3927 90489090
Vascular parkinsonism 11.55 9.54 5 135425 122 90492895
SJS-TEN overlap 11.49 9.54 11 135419 1097 90491920
Palmar-plantar erythrodysaesthesia syndrome 11.48 9.54 15 135415 28008 90465009
Subcutaneous emphysema 11.45 9.54 11 135419 1101 90491916
Infusion site swelling 11.39 9.54 41 135389 11679 90481338
Dengue fever 11.39 9.54 10 135420 892 90492125
Injection site bruising 11.37 9.54 40 135390 52267 90440750
Hepatitis acute 11.37 9.54 39 135391 10848 90482169
Respiratory tract infection fungal 11.35 9.54 8 135422 518 90492499
Respiratory syncytial virus infection 11.35 9.54 38 135392 10442 90482575
Abdominal wall haematoma 11.34 9.54 19 135411 3333 90489684
Nasopharyngitis 11.33 9.54 495 134935 406609 90086408
Angina bullosa haemorrhagica 11.33 9.54 5 135425 128 90492889
Intraocular pressure test 11.28 9.54 4 135426 56 90492961
Osteogenesis imperfecta 11.22 9.54 10 135420 910 90492107
Otitis media fungal 11.17 9.54 3 135427 15 90493002
Ocular rosacea 11.17 9.54 3 135427 15 90493002
International normalised ratio increased 11.17 9.54 114 135316 47202 90445815
Leukocytosis 11.17 9.54 82 135348 30908 90462109
HIV-associated neurocognitive disorder 11.15 9.54 5 135425 133 90492884
Vaginal abscess 11.13 9.54 8 135422 534 90492483
Ruptured ectopic pregnancy 11.12 9.54 8 135422 535 90492482
Hypertransaminasaemia 11.09 9.54 50 135380 15775 90477242
Adverse reaction 11.08 9.54 17 135413 29695 90463322
Ureteric perforation 11.01 9.54 3 135427 16 90493001
Multiple organ dysfunction syndrome 10.99 9.54 153 135277 68183 90424834
Septic rash 10.97 9.54 4 135426 61 90492956
Pharyngitis 10.93 9.54 63 135367 21884 90471133
Forced vital capacity decreased 10.92 9.54 11 135419 1167 90491850
Eyelid oedema 10.91 9.54 40 135390 11494 90481523
Osteoporosis 10.88 9.54 92 135338 96439 90396578
Atelectasis 10.83 9.54 68 135362 24341 90468676
Acute disseminated encephalomyelitis 10.81 9.54 6 135424 254 90492763
Abscess bacterial 10.79 9.54 6 135424 255 90492762
Urticaria 10.77 9.54 571 134859 312163 90180854
Alanine aminotransferase increased 10.77 9.54 242 135188 118096 90374921
Developmental delay 10.77 9.54 13 135417 1687 90491330
Tooth discolouration 10.76 9.54 11 135419 1187 90491830
Injection site haemorrhage 10.76 9.54 16 135414 28302 90464715
Basal cell carcinoma 10.72 9.54 21 135409 33368 90459649
Multiple sclerosis relapse 10.71 9.54 41 135389 52264 90440753
Hyponatraemia 10.67 9.54 138 135292 133400 90359617
Central nervous system fungal infection 10.65 9.54 5 135425 148 90492869
Increased upper airway secretion 10.63 9.54 20 135410 3841 90489176
Lymphangitis 10.60 9.54 10 135420 979 90492038
Purpura 10.59 9.54 47 135383 14731 90478286
Sensory loss 10.56 9.54 7 135423 18068 90474949
Paraesthesia 10.53 9.54 289 135141 250037 90242980
Motor dysfunction 10.51 9.54 8 135422 19222 90473795
Vulvovaginal candidiasis 10.49 9.54 20 135410 3880 90489137
Product colour issue 10.44 9.54 9 135421 783 90492234
Acne cystic 10.41 9.54 9 135421 786 90492231
Glossitis 10.40 9.54 19 135411 3568 90489449
Clostridium difficile colitis 10.40 9.54 72 135358 26634 90466383
Skin haemorrhage 10.34 9.54 10 135420 21370 90471647
Hepatitis fulminant 10.33 9.54 20 135410 3925 90489092
Pneumonia mycoplasmal 10.32 9.54 10 135420 1012 90492005
Cardiolipin antibody positive 10.27 9.54 5 135425 161 90492856
Haematotoxicity 10.24 9.54 3 135427 12532 90480485
Infusion site erythema 10.19 9.54 44 135386 13626 90479391
Burning sensation 10.18 9.54 142 135288 63310 90429707
Pelvic fracture 10.17 9.54 5 135425 15214 90477803
Anxiety 10.15 9.54 563 134867 309209 90183808
Creatinine renal clearance decreased 10.15 9.54 8 135422 18891 90474126
Arterial occlusive disease 10.13 9.54 3 135427 12443 90480574
Status epilepticus 10.13 9.54 8 135422 18866 90474151
Term birth 10.07 9.54 5 135425 168 90492849
Chronic spontaneous urticaria 10.06 9.54 13 135417 1807 90491210
Hallucination, visual 10.04 9.54 64 135366 23028 90469989
Muscle spasms 10.04 9.54 293 135137 251590 90241427
Lower respiratory tract congestion 10.02 9.54 18 135412 3338 90489679
Lip squamous cell carcinoma 10.02 9.54 5 135425 170 90492847
Haematocrit decreased 9.97 9.54 101 135329 41731 90451286
Metabolic acidosis 9.95 9.54 46 135384 55630 90437387
Injection site warmth 9.94 9.54 7 135423 17508 90475509
Pyloric stenosis 9.93 9.54 7 135423 453 90492564
Device malfunction 9.92 9.54 10 135420 20967 90472050
Spinal fusion surgery 9.92 9.54 3 135427 12280 90480737
Subcutaneous abscess 9.89 9.54 27 135403 6639 90486378
Cell-mediated cytotoxicity 9.86 9.54 3 135427 25 90492992
Cholesterosis 9.85 9.54 7 135423 459 90492558
Myelodysplastic syndrome 9.85 9.54 10 135420 20893 90472124
Aspartate aminotransferase increased 9.84 9.54 212 135218 102725 90390292
Thrombocytopenic purpura 9.83 9.54 13 135417 1848 90491169
Bronchiolitis 9.80 9.54 18 135412 3394 90489623
Eosinophilic oesophagitis 9.79 9.54 9 135421 852 90492165
Cyanosis 9.79 9.54 56 135374 19399 90473618
Hypercalcaemia 9.78 9.54 23 135407 34217 90458800
Placental necrosis 9.76 9.54 3 135427 26 90492991
ECG signs of myocardial ischaemia 9.75 9.54 4 135426 85 90492932
Alveolar proteinosis 9.66 9.54 9 135421 867 90492150
Pneumopericardium 9.58 9.54 4 135426 89 90492928
Blood alkaline phosphatase increased 9.58 9.54 112 135318 47967 90445050
Hypoproteinaemia 9.57 9.54 17 135413 3125 90489892
Dermatitis atopic 9.57 9.54 64 135366 23408 90469609

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1548.54 11.15 3869 87754 634466 41895246
Infective pulmonary exacerbation of cystic fibrosis 587.63 11.15 302 91321 7516 42522196
Asthma 558.67 11.15 679 90944 61635 42468077
Electrocardiogram QT prolonged 453.48 11.15 537 91086 47408 42482304
Wheezing 334.31 11.15 495 91128 54286 42475426
Drug ineffective for unapproved indication 319.64 11.15 443 91180 45720 42483992
Obstructive airways disorder 314.84 11.15 324 91299 24435 42505277
Productive cough 282.17 11.15 443 91180 51124 42478588
Full blood count abnormal 242.55 11.15 310 91313 29566 42500146
Haemoptysis 233.91 11.15 383 91240 45784 42483928
Bronchiectasis 206.26 11.15 223 91400 17796 42511916
Condition aggravated 203.72 11.15 1100 90523 259654 42270058
Breath sounds abnormal 200.26 11.15 183 91440 11910 42517802
Sleep disorder due to a general medical condition 185.92 11.15 208 91415 17245 42512467
Forced expiratory volume decreased 176.68 11.15 140 91483 7490 42522222
Drug abuse 175.39 11.15 13 91610 104758 42424954
Drug hypersensitivity 169.38 11.15 534 91089 98855 42430857
Immune reconstitution inflammatory syndrome 168.95 11.15 154 91469 9989 42519723
Long QT syndrome 167.54 11.15 97 91526 3070 42526642
Pulmonary vasculitis 164.79 11.15 124 91499 6142 42523570
Product use in unapproved indication 147.78 11.15 784 90839 183672 42346040
Drug interaction 146.81 11.15 1029 90594 265970 42263742
Cystic fibrosis 141.84 11.15 75 91548 1980 42527732
Congenital hiatus hernia 138.07 11.15 111 91512 6063 42523649
Cough 137.90 11.15 750 90873 177353 42352359
Neuritis 135.23 11.15 110 91513 6110 42523602
Total lung capacity abnormal 132.83 11.15 95 91528 4348 42525364
Respiratory symptom 126.31 11.15 137 91486 10969 42518743
Completed suicide 125.50 11.15 27 91596 96438 42433274
Fall 120.67 11.15 199 91424 234321 42295391
Pulmonary alveolar haemorrhage 117.48 11.15 152 91471 14664 42515048
Drug ineffective 116.57 11.15 1949 89674 628248 41901464
Malignant melanoma in situ 116.01 11.15 73 91550 2694 42527018
Dyspnoea 115.87 11.15 1455 90168 441166 42088546
Malignant neoplasm progression 114.22 11.15 45 91578 108355 42421357
Death 113.39 11.15 575 91048 470610 42059102
Loss of personal independence in daily activities 112.23 11.15 296 91327 49520 42480192
Febrile neutropenia 110.79 11.15 142 91481 185561 42344151
Drug resistance 109.20 11.15 233 91390 34015 42495697
Neurological symptom 107.99 11.15 120 91503 9871 42519841
Eosinophilic granulomatosis with polyangiitis 107.88 11.15 112 91511 8526 42521186
Hypertransaminasaemia 106.99 11.15 115 91508 9112 42520600
Therapeutic product effect incomplete 105.42 11.15 364 91259 70575 42459137
Hepatitis 105.25 11.15 201 91422 27099 42502613
Ototoxicity 96.63 11.15 61 91562 2264 42527448
Lung disorder 96.23 11.15 273 91350 47650 42482062
Chronic obstructive pulmonary disease 93.90 11.15 324 91299 62790 42466922
Pulmonary function test decreased 93.45 11.15 86 91537 5646 42524066
Mycobacterium avium complex infection 93.43 11.15 66 91557 2961 42526751
Conjunctivitis allergic 93.11 11.15 87 91536 5824 42523888
Somnolence 92.59 11.15 100 91523 141005 42388707
Toxicity to various agents 92.46 11.15 224 91399 228912 42300800
Mite allergy 88.73 11.15 79 91544 4967 42524745
Spirometry abnormal 87.39 11.15 79 91544 5067 42524645
Mycotic allergy 82.89 11.15 75 91548 4816 42524896
Solar lentigo 79.97 11.15 35 91588 599 42529113
Dysplastic naevus 77.23 11.15 35 91588 653 42529059
Eosinophil count abnormal 76.24 11.15 29 91594 339 42529373
Pathogen resistance 74.89 11.15 107 91516 11343 42518369
Photodermatosis 73.90 11.15 35 91588 725 42528987
Drug effective for unapproved indication 72.25 11.15 80 91543 6553 42523159
Dust allergy 71.79 11.15 72 91551 5260 42524452
No adverse event 71.34 11.15 215 91408 38806 42490906
Vasculitis 70.36 11.15 135 91488 18259 42511453
Sputum increased 68.89 11.15 56 91567 3107 42526605
Antineutrophil cytoplasmic antibody positive 66.36 11.15 63 91560 4302 42525410
Stevens-Johnson syndrome 61.80 11.15 143 91480 22035 42507677
Respiratory failure 61.71 11.15 479 91144 127653 42402059
Myocardial infarction 61.14 11.15 108 91515 123901 42405811
Fatigue 60.10 11.15 623 91000 435018 42094694
Product packaging quantity issue 60.02 11.15 37 91586 1316 42528396
Mucormycosis 59.33 11.15 75 91548 7068 42522644
Toxic epidermal necrolysis 59.26 11.15 158 91465 26592 42503120
Neutropenia 58.89 11.15 225 91398 199206 42330506
Micturition urgency 57.91 11.15 97 91526 11801 42517911
Confusional state 57.67 11.15 177 91446 167420 42362292
Pulmonary fibrosis 57.50 11.15 156 91467 26525 42503187
Deafness neurosensory 56.83 11.15 54 91569 3692 42526020
Sputum discoloured 56.68 11.15 88 91535 10044 42519668
Hypoxia 55.98 11.15 297 91326 69489 42460223
Acute respiratory distress syndrome 55.13 11.15 166 91457 29942 42499770
Prostate cancer 55.06 11.15 14 91609 44629 42485083
Hypercholesterolaemia 55.03 11.15 99 91524 12750 42516962
Constipation 54.70 11.15 173 91450 162118 42367594
Vanishing bile duct syndrome 53.63 11.15 39 91584 1832 42527880
Respiratory disorder 53.60 11.15 135 91488 21950 42507762
Torsade de pointes 52.84 11.15 78 91545 8516 42521196
Coma 51.99 11.15 25 91598 53529 42476183
Parathyroid gland enlargement 51.02 11.15 18 91605 167 42529545
Upper respiratory fungal infection 50.19 11.15 18 91605 176 42529536
Normochromic normocytic anaemia 48.52 11.15 77 91546 8954 42520758
General physical health deterioration 48.36 11.15 165 91458 151081 42378631
Lung diffusion disorder 48.26 11.15 17 91606 157 42529555
Anaemia 48.09 11.15 379 91244 279899 42249813
Dizziness 48.07 11.15 326 91297 248928 42280784
Mycobacterial infection 47.37 11.15 42 91581 2626 42527086
Benign prostatic hyperplasia 47.29 11.15 125 91498 20927 42508785
Intentional overdose 47.01 11.15 26 91597 51430 42478282
Mycobacterium chelonae infection 46.70 11.15 30 91593 1148 42528564
Bronchiolitis obliterans syndrome 45.27 11.15 19 91604 292 42529420
Bronchial hyperreactivity 43.81 11.15 35 91588 1894 42527818
Mucocutaneous disorder 43.77 11.15 16 91607 166 42529546
Decreased appetite 43.27 11.15 241 91382 192896 42336816
Overdose 43.09 11.15 102 91521 105162 42424550
Pneumonia 42.95 11.15 1199 90424 420950 42108762
Dehydration 42.43 11.15 159 91464 141608 42388104
Dyspnoea exertional 41.98 11.15 216 91407 49932 42479780
Acute respiratory failure 41.77 11.15 180 91443 38678 42491034
Capillaritis 41.41 11.15 36 91587 2192 42527520
Asthma-chronic obstructive pulmonary disease overlap syndrome 41.32 11.15 31 91592 1528 42528184
Lung transplant 41.25 11.15 37 91586 2349 42527363
Stenotrophomonas infection 40.91 11.15 45 91578 3659 42526053
Nodule 40.77 11.15 86 91537 12448 42517264
Cystic fibrosis respiratory infection suppression 40.69 11.15 17 91606 258 42529454
Pseudomonas infection 40.39 11.15 99 91524 15824 42513888
Bronchopulmonary aspergillosis 40.27 11.15 112 91511 19317 42510395
Bronchitis 39.99 11.15 204 91419 46997 42482715
Lung transplant rejection 39.87 11.15 26 91597 1021 42528691
Seizure 39.57 11.15 130 91493 120431 42409281
Cardiac failure 39.53 11.15 109 91514 106747 42422965
Platelet count decreased 39.18 11.15 159 91464 138422 42391290
Gastrooesophageal reflux disease 39.14 11.15 196 91427 44827 42484885
Sinusitis 39.10 11.15 203 91420 47089 42482623
Aspergillus infection 38.63 11.15 97 91526 15740 42513972
Atypical mycobacterium test positive 38.40 11.15 12 91611 73 42529639
Hepatitis acute 38.24 11.15 69 91554 8906 42520806
Forced expiratory volume 37.60 11.15 13 91610 113 42529599
Pain 37.08 11.15 342 91281 244506 42285206
Tachyarrhythmia 37.05 11.15 44 91579 3888 42525824
Pulmonary cavitation 36.96 11.15 27 91596 1277 42528435
Rheumatoid arthritis 36.57 11.15 23 91600 42417 42487295
Vitamin K deficiency 36.33 11.15 18 91605 413 42529299
Joint injury 35.91 11.15 90 91533 14586 42515126
Disseminated strongyloidiasis 35.71 11.15 19 91604 508 42529204
Myelosuppression 34.76 11.15 22 91601 40439 42489273
Mycobacterium abscessus infection 34.26 11.15 21 91602 739 42528973
Pulmonary function test abnormal 33.76 11.15 35 91588 2659 42527053
Atypical mycobacterial infection 33.64 11.15 26 91597 1340 42528372
Hypercapnia 33.45 11.15 49 91574 5312 42524400
Asthenia 33.33 11.15 415 91208 280378 42249334
Urinary tract infection 33.31 11.15 106 91517 99178 42430534
Deafness 32.59 11.15 81 91542 13059 42516653
Cystic fibrosis related diabetes 31.88 11.15 13 91610 185 42529527
Wrong technique in product usage process 31.68 11.15 27 91596 42608 42487104
Oedema peripheral 31.44 11.15 168 91455 135908 42393804
Eosinophilia 31.31 11.15 147 91476 32752 42496960
COVID-19 treatment 31.19 11.15 14 91609 255 42529457
Lung hyperinflation 31.12 11.15 23 91600 1108 42528604
Liver injury 30.84 11.15 101 91522 19047 42510665
Neutrophil count decreased 30.54 11.15 56 91567 63359 42466353
Arteriosclerosis coronary artery 30.52 11.15 99 91524 18578 42511134
HIV associated nephropathy 30.48 11.15 15 91608 339 42529373
Hyponatraemia 30.21 11.15 114 91509 101348 42428364
Ascites 30.10 11.15 47 91576 56631 42473081
Obliterative bronchiolitis 30.00 11.15 25 91598 1436 42528276
Myoclonic dystonia 29.98 11.15 10 91613 77 42529635
Sedation 29.92 11.15 14 91609 30461 42499251
Suicide attempt 29.84 11.15 33 91590 46067 42483645
HIV infection 29.65 11.15 25 91598 1460 42528252
Arthralgia 29.22 11.15 291 91332 204947 42324765
Bronchial disorder 28.87 11.15 24 91599 1374 42528338
Rash erythematous 28.81 11.15 141 91482 31950 42497762
Jarisch-Herxheimer reaction 28.30 11.15 19 91604 784 42528928
Cerebral infarction 28.10 11.15 16 91607 31153 42498559
Drug-induced liver injury 28.06 11.15 159 91464 38114 42491598
Hepatocellular injury 28.04 11.15 113 91510 23565 42506147
Cryptococcal meningoencephalitis 27.82 11.15 12 91611 198 42529514
Transaminases increased 27.76 11.15 142 91481 32743 42496969
Cerebrovascular accident 27.75 11.15 111 91512 97049 42432663
Scleroderma 27.67 11.15 26 91597 1752 42527960
Biphasic mesothelioma 27.36 11.15 9 91614 66 42529646
Alanine aminotransferase increased 27.07 11.15 300 91323 88106 42441606
Interstitial lung disease 26.85 11.15 83 91540 78379 42451333
Factor V inhibition 26.77 11.15 12 91611 218 42529494
Back pain 26.51 11.15 187 91436 141589 42388123
Drug reaction with eosinophilia and systemic symptoms 26.50 11.15 168 91455 41907 42487805
Therapeutic product effect decreased 26.48 11.15 27 91596 39123 42490589
Urethritis mycoplasmal 26.35 11.15 7 91616 21 42529691
Hyperkalaemia 26.22 11.15 87 91536 80371 42449341
Hypothyroidism 26.02 11.15 137 91486 31947 42497765
Upper-airway cough syndrome 25.94 11.15 39 91584 4327 42525385
Chest discomfort 25.86 11.15 229 91394 63387 42466325
Rubber sensitivity 25.66 11.15 14 91609 394 42529318
Fungal disease carrier 25.60 11.15 14 91609 396 42529316
Dysarthria 25.21 11.15 29 91594 39778 42489934
Rash morbilliform 24.54 11.15 37 91586 4116 42525596
Mycoplasma infection 24.52 11.15 16 91607 629 42529083
Hypotension 24.46 11.15 398 91225 257233 42272479
Urinary retention 24.38 11.15 33 91590 42181 42487531
Methaemoglobinaemia 24.10 11.15 44 91579 5730 42523982
Actinic keratosis 23.60 11.15 41 91582 5135 42524577
Blood pressure increased 23.45 11.15 126 91497 101802 42427910
Transient ischaemic attack 23.32 11.15 138 91485 33601 42496111
Secretion discharge 23.24 11.15 51 91572 7584 42522128
Impaired quality of life 23.03 11.15 75 91548 14102 42515610
Genital erosion 22.89 11.15 12 91611 311 42529401
NPM1 gene mutation 22.80 11.15 9 91614 117 42529595
Hepatitis cholestatic 22.74 11.15 59 91564 9765 42519947
Blood pressure fluctuation 22.61 11.15 15 91608 26893 42502819
Cryptococcosis 22.47 11.15 31 91592 3180 42526532
Graft versus host disease in lung 22.37 11.15 16 91607 732 42528980
Gastrointestinal haemorrhage 22.37 11.15 121 91502 97605 42432107
Haemoglobin decreased 22.26 11.15 180 91443 132291 42397421
Arteriosclerosis 22.23 11.15 87 91536 17902 42511810
Joint warmth 22.06 11.15 15 91608 632 42529080
Memory impairment 21.90 11.15 47 91576 50175 42479537
Nasal mucosal disorder 21.76 11.15 9 91614 133 42529579
Infusion related reaction 21.76 11.15 63 91560 60743 42468969
Product quality issue 21.70 11.15 86 91537 17796 42511916
Rash maculovesicular 21.69 11.15 7 91616 48 42529664
COVID-19 pneumonia 21.62 11.15 98 91525 21515 42508197
Hypertriglyceridaemia 21.61 11.15 59 91564 10067 42519645
Respiratory distress 21.59 11.15 159 91464 41661 42488051
Pseudomembranous colitis 21.55 11.15 30 91593 3103 42526609
Odynophagia 21.50 11.15 46 91577 6724 42522988
Oropharyngeal candidiasis 21.40 11.15 17 91606 912 42528800
Respiratory depression 21.27 11.15 7 91616 18861 42510851
Gonorrhoea 21.09 11.15 7 91616 53 42529659
Deafness bilateral 20.93 11.15 20 91603 1377 42528335
Palmar-plantar erythrodysaesthesia syndrome 20.92 11.15 9 91614 20573 42509139
Neoplasm progression 20.78 11.15 19 91604 28981 42500731
Injection site pain 20.60 11.15 60 91563 57738 42471974
Carbon dioxide increased 20.57 11.15 19 91604 1253 42528459
CD4 lymphocytes increased 20.56 11.15 9 91614 154 42529558
Hepatic necrosis 20.52 11.15 33 91590 3880 42525832
Haemolytic anaemia 20.46 11.15 65 91558 12062 42517650
White blood cell count decreased 20.44 11.15 146 91477 110250 42419462
Oral blood blister 20.35 11.15 6 91617 29 42529683
Distal intestinal obstruction syndrome 20.32 11.15 13 91610 494 42529218
Acquired immunodeficiency syndrome 20.29 11.15 13 91610 495 42529217
Contusion 20.28 11.15 37 91586 41948 42487764
Lip erythema 20.27 11.15 8 91615 104 42529608
Inguinal hernia repair 20.21 11.15 11 91612 308 42529404
Jaw cyst 20.02 11.15 6 91617 31 42529681
Urosepsis 19.94 11.15 4 91619 15016 42514696
Acute hepatic failure 19.83 11.15 81 91542 16992 42512720
Bladder cancer 19.79 11.15 6 91617 17041 42512671
Syncope 19.62 11.15 129 91494 99277 42430435
Cytokine storm 19.61 11.15 16 91607 892 42528820
Prostatic specific antigen increased 19.58 11.15 6 91617 16919 42512793
Cystic fibrosis lung 19.47 11.15 7 91616 69 42529643
Cognitive disorder 19.45 11.15 27 91596 34145 42495567
Tumour lysis syndrome 19.21 11.15 12 91611 22219 42507493
Depressed level of consciousness 19.21 11.15 47 91576 47923 42481789
Herpes simplex viraemia 19.17 11.15 8 91615 121 42529591
Musculoskeletal stiffness 19.14 11.15 62 91561 57703 42472009
Oral mucosa erosion 19.09 11.15 17 91606 1069 42528643
Bronchopleural fistula 18.97 11.15 14 91609 673 42529039
Sputum retention 18.93 11.15 14 91609 675 42529037
Rhinocerebral mucormycosis 18.91 11.15 14 91609 676 42529036
Balance disorder 18.83 11.15 47 91576 47598 42482114
Rhonchi 18.76 11.15 23 91600 2100 42527612
Iris adhesions 18.74 11.15 10 91613 269 42529443
Alcohol intolerance 18.64 11.15 11 91612 361 42529351
Mononeuropathy 18.61 11.15 10 91613 273 42529439
Malabsorption from administration site 18.54 11.15 7 91616 80 42529632
Enterovirus infection 18.41 11.15 18 91605 1275 42528437
Mediastinal shift 18.35 11.15 4 91619 3 42529709
Bacterial pericarditis 18.31 11.15 7 91616 83 42529629
Lip oedema 18.29 11.15 28 91595 3156 42526556
Disease progression 18.28 11.15 209 91414 143447 42386265
Rhinitis allergic 18.27 11.15 31 91592 3811 42525901
Liver function test 18.24 11.15 7 91616 84 42529628
Blood immunoglobulin E increased 18.24 11.15 30 91593 3595 42526117
Acute myocardial infarction 18.20 11.15 64 91559 58101 42471611
Blood glucose increased 18.13 11.15 89 91534 73610 42456102
Atypical mycobacterial lower respiratory tract infection 18.12 11.15 6 91617 45 42529667
Influenza 18.12 11.15 209 91414 61966 42467746
Enterobacter infection 18.09 11.15 27 91596 2977 42526735
Rectal haemorrhage 18.04 11.15 51 91572 49555 42480157
Oesophageal injury 18.03 11.15 9 91614 210 42529502
Hypoglycaemia 17.97 11.15 67 91556 59787 42469925
Mouth injury 17.95 11.15 11 91612 387 42529325
Vestibular disorder 17.92 11.15 17 91606 1160 42528552
Acoustic neuroma 17.91 11.15 8 91615 144 42529568
Pneumonia aspiration 17.83 11.15 52 91571 50026 42479686
Andersen-Tawil syndrome 17.81 11.15 4 91619 4 42529708
FEV1/FVC ratio abnormal 17.79 11.15 6 91617 48 42529664
Nervous system neoplasm 17.61 11.15 8 91615 150 42529562
Disturbance in attention 17.60 11.15 23 91600 29843 42499869
Bifidobacterium infection 17.53 11.15 7 91616 94 42529618
Pharyngeal erythema 17.47 11.15 14 91609 761 42528951
Clavicle fracture 17.44 11.15 25 91598 2658 42527054
Pneumonia mycoplasmal 17.39 11.15 14 91609 766 42528946
Pneumothorax 17.38 11.15 98 91525 23445 42506267
Deafness unilateral 17.20 11.15 22 91601 2097 42527615
Infantile vomiting 17.20 11.15 7 91616 99 42529613
Antinuclear antibody negative 17.16 11.15 5 91618 23 42529689
Superinfection 17.02 11.15 26 91597 2925 42526787
Urinary incontinence 17.00 11.15 13 91610 21655 42508057
Restrictive allograft syndrome 16.99 11.15 5 91618 24 42529688
Tendon disorder 16.99 11.15 28 91595 3361 42526351
Photosensitivity reaction 16.98 11.15 63 91560 12639 42517073
Conjunctival hyperaemia 16.95 11.15 27 91596 3149 42526563
Serum sickness-like reaction 16.90 11.15 9 91614 241 42529471
Metastases to liver 16.82 11.15 7 91616 16319 42513393
Hyperthyroidism 16.74 11.15 5 91618 14336 42515376
Chimerism 16.64 11.15 9 91614 249 42529463
Respiratory syncytial virus infection 16.60 11.15 43 91580 7109 42522603
Multiple sclerosis relapse 16.60 11.15 5 91618 14259 42515453
Myopia 16.59 11.15 17 91606 1274 42528438
Myasthenia gravis crisis 16.39 11.15 14 91609 832 42528880
Pneumonia pseudomonal 16.34 11.15 34 91589 4875 42524837
Intentional product misuse 16.26 11.15 73 91550 61827 42467885
Infective chondritis 16.20 11.15 4 91619 8 42529704
Premature baby 16.19 11.15 95 91528 23058 42506654
C-reactive protein increased 16.08 11.15 76 91547 63484 42466228
Headache 16.00 11.15 392 91231 238977 42290735
Disorientation 15.91 11.15 34 91589 36355 42493357
Injection site haemorrhage 15.84 11.15 3 91620 11733 42517979
Eye swelling 15.84 11.15 59 91564 11861 42517851
Cardiogenic shock 15.83 11.15 33 91590 35607 42494105
Metastases to bone 15.83 11.15 6 91617 14803 42514909
Blood pressure decreased 15.80 11.15 68 91555 58264 42471448
Linear IgA disease 15.78 11.15 21 91602 2082 42527630
Rash maculo-papular 15.75 11.15 136 91487 37367 42492345
Delusion 15.70 11.15 6 91617 14728 42514984
Disseminated cryptococcosis 15.65 11.15 20 91603 1905 42527807
Viral infection 15.56 11.15 92 91531 22391 42507321
Osteonecrosis of jaw 15.50 11.15 11 91612 19038 42510674
Haemoglobin E disease 15.43 11.15 3 91620 0 42529712
Pneumonia serratia 15.43 11.15 3 91620 0 42529712
Strongyloidiasis 15.41 11.15 27 91596 3404 42526308
Leukocytosis 15.36 11.15 113 91510 29595 42500117
Head injury 15.33 11.15 13 91610 20569 42509143
Lung infiltration 15.18 11.15 65 91558 13924 42515788
Plasma cell myeloma 15.12 11.15 52 91571 47526 42482186
Small intestinal obstruction 15.04 11.15 9 91614 17052 42512660
Kidney infection 15.00 11.15 40 91583 6730 42522982
Mucosal inflammation 15.00 11.15 55 91568 49319 42480393
Cardiac failure congestive 14.98 11.15 115 91508 85487 42444225
Primary adrenal insufficiency 14.94 11.15 9 91614 307 42529405
Tinnitus 14.92 11.15 110 91513 28828 42500884
Immunosuppressant drug level decreased 14.91 11.15 19 91604 1805 42527907
Aggression 14.91 11.15 47 91576 44116 42485596
Polyneuropathy 14.89 11.15 11 91612 18650 42511062
Coinfection 14.87 11.15 6 91617 83 42529629
Ejection fraction abnormal 14.77 11.15 16 91607 1279 42528433
Cholestasis 14.75 11.15 121 91502 32758 42496954
Respiratory tract infection 14.70 11.15 102 91521 26220 42503492
Pneumomediastinum 14.63 11.15 25 91598 3091 42526621
Dyskinesia 14.51 11.15 20 91603 25370 42504342
Diabetic ketoacidosis 14.48 11.15 16 91607 22351 42507361
Heart rate decreased 14.46 11.15 36 91587 36496 42493216
Thrombocytopenia 14.29 11.15 306 91317 189973 42339739
Penile abscess 14.23 11.15 7 91616 158 42529554
Sinus congestion 14.23 11.15 40 91583 6940 42522772
Glycosylated haemoglobin increased 14.21 11.15 5 91618 12919 42516793
Haemophilus infection 14.21 11.15 17 91606 1514 42528198
Appendicitis 14.19 11.15 14 91609 20599 42509113
Decreased activity 14.18 11.15 33 91590 5102 42524610
Laziness 14.13 11.15 10 91613 450 42529262
Herpes zoster 14.11 11.15 40 91583 38837 42490875
Symmetrical drug-related intertriginous and flexural exanthema 14.10 11.15 13 91610 855 42528857
Mastocytosis 14.02 11.15 5 91618 48 42529664
Extrapyramidal disorder 13.99 11.15 9 91614 16403 42513309
Blood uric acid increased 13.99 11.15 8 91615 15539 42514173
Dystonia 13.98 11.15 5 91618 12785 42516927
Seborrhoea 13.94 11.15 8 91615 249 42529463
Lymph node palpable 13.93 11.15 5 91618 49 42529663
Basal cell carcinoma 13.92 11.15 17 91606 22716 42506996
Glucose-6-phosphate dehydrogenase deficiency 13.88 11.15 8 91615 251 42529461
Rhinovirus infection 13.82 11.15 38 91585 6510 42523202
Tooth discolouration 13.80 11.15 10 91613 467 42529245
Hypofibrinogenaemia 13.78 11.15 19 91604 1948 42527764
Diarrhoea 13.76 11.15 831 90792 460018 42069694
Chronic graft versus host disease 13.76 11.15 36 91587 5989 42523723
Lethargy 13.74 11.15 53 91570 46837 42482875
Mastication disorder 13.73 11.15 18 91605 1758 42527954
Blood culture negative 13.58 11.15 5 91618 53 42529659
Acute generalised exanthematous pustulosis 13.54 11.15 45 91578 8550 42521162
Hilar lymphadenopathy 13.52 11.15 15 91608 1231 42528481
Flushing 13.51 11.15 38 91585 36990 42492722
Blood phosphorus increased 13.51 11.15 5 91618 12520 42517192
Sinusitis fungal 13.41 11.15 12 91611 759 42528953
Heart rate irregular 13.41 11.15 9 91614 16041 42513671
Infective exacerbation of bronchiectasis 13.40 11.15 10 91613 489 42529223
Depression 13.39 11.15 164 91459 111199 42418513
Nausea 13.39 11.15 707 90916 396092 42133620
Papillary muscle rupture 13.36 11.15 3 91620 3 42529709
Pernio-like erythema 13.36 11.15 3 91620 3 42529709
Reaction to colouring 13.36 11.15 3 91620 3 42529709
Substance-induced psychotic disorder 13.33 11.15 23 91600 2866 42526846
Metastases to lung 13.30 11.15 4 91619 11420 42518292
Abdominal distension 13.21 11.15 95 91528 71640 42458072
Bronchopulmonary aspergillosis allergic 13.19 11.15 30 91593 4568 42525144
Device malfunction 13.16 11.15 5 91618 12322 42517390
Tremor 13.12 11.15 139 91484 96790 42432922
Device leakage 13.12 11.15 3 91620 10282 42519430
Respiratory gas exchange disorder 13.01 11.15 10 91613 511 42529201
Orthostatic hypotension 13 11.15 29 91594 30541 42499171
Hepatomegaly 12.97 11.15 55 91568 11730 42517982
Bronchoalveolar lavage 12.95 11.15 5 91618 61 42529651
Immunodeficiency common variable 12.89 11.15 8 91615 288 42529424
Cerebral haemorrhage 12.78 11.15 42 91581 38924 42490788
Abdominal wall haematoma 12.75 11.15 20 91603 2302 42527410
Myoglobinaemia 12.70 11.15 7 91616 201 42529511
Gait disturbance 12.68 11.15 142 91481 97858 42431854
Drug eruption 12.64 11.15 89 91534 22986 42506726
Muscle spasms 12.64 11.15 121 91502 85923 42443789
Exercise tolerance decreased 12.60 11.15 35 91588 6031 42523681
Hyperhidrosis 12.58 11.15 129 91494 90383 42439329
Pleural fistula 12.58 11.15 4 91619 26 42529686
Angina pectoris 12.57 11.15 33 91590 32863 42496849
Haematochezia 12.47 11.15 74 91549 58362 42471350
Contraindicated product administered 12.45 11.15 22 91601 25250 42504462
Lip ulceration 12.44 11.15 13 91610 997 42528715
Sleep disorder 12.41 11.15 158 91465 47937 42481775
Measles 12.34 11.15 8 91615 311 42529401
Blood pressure systolic increased 12.33 11.15 26 91597 27942 42501770
Chills 12.29 11.15 136 91487 93930 42435782
Palatal oedema 12.29 11.15 13 91610 1011 42528701
Stomatitis 12.25 11.15 61 91562 50268 42479444
Borderline personality disorder 12.24 11.15 9 91614 430 42529282
Lower gastrointestinal haemorrhage 12.20 11.15 4 91619 10804 42518908
Propofol infusion syndrome 12.18 11.15 14 91609 1195 42528517
Ureteric dilatation 12.16 11.15 7 91616 219 42529493
Antibiotic associated colitis 12.15 11.15 3 91620 6 42529706
Cutaneous extramedullary haemopoiesis 12.15 11.15 3 91620 6 42529706
Achromotrichia congenital 12.15 11.15 3 91620 6 42529706
Rash 12.11 11.15 719 90904 276235 42253477
Muscular weakness 12.02 11.15 118 91505 83380 42446332
Upper respiratory tract infection 11.95 11.15 141 91482 42032 42487680
Accidental overdose 11.95 11.15 27 91596 28303 42501409
Full blood count decreased 11.95 11.15 16 91607 20544 42509168
Haematuria 11.92 11.15 74 91549 57725 42471987
Melaena 11.87 11.15 43 91580 38703 42491009
Colitis ulcerative 11.82 11.15 24 91599 26151 42503561
Hospitalisation 11.82 11.15 225 91398 74105 42455607
ADAMTS13 activity decreased 11.79 11.15 6 91617 146 42529566
Coagulation factor V level increased 11.75 11.15 4 91619 33 42529679
Product prescribing error 11.75 11.15 24 91599 26088 42503624
Tongue discolouration 11.74 11.15 14 91609 1242 42528470
Stress 11.69 11.15 52 91571 44160 42485552
Wrong dose 11.68 11.15 13 91610 1071 42528641
Pemphigoid 11.68 11.15 5 91618 11462 42518250
Cystitis 11.67 11.15 53 91570 11645 42518067
Rhodococcus infection 11.66 11.15 8 91615 342 42529370
Clostridium difficile colitis 11.66 11.15 82 91541 21170 42508542
Pancreatic failure 11.65 11.15 13 91610 1074 42528638
Optic neuropathy 11.59 11.15 20 91603 2492 42527220
Rheumatic fever 11.55 11.15 4 91619 35 42529677
Pyloric stenosis 11.53 11.15 12 91611 916 42528796
Treatment failure 11.53 11.15 194 91429 62430 42467282
Pneumonia staphylococcal 11.48 11.15 24 91599 3452 42526260
Nervous system disorder 11.47 11.15 12 91611 17183 42512529
Bladder discomfort 11.43 11.15 6 91617 156 42529556
Cerebral toxoplasmosis 11.42 11.15 18 91605 2080 42527632
Cytokine release syndrome 11.40 11.15 53 91570 44474 42485238
Forced vital capacity decreased 11.40 11.15 12 91611 928 42528784
Metastases to central nervous system 11.40 11.15 4 91619 10351 42519361
Viral rash 11.36 11.15 6 91617 158 42529554
Intestinal obstruction 11.36 11.15 26 91597 27132 42502580
Tuberculosis gastrointestinal 11.35 11.15 7 91616 249 42529463
Diabetes mellitus 11.34 11.15 79 91544 60008 42469704
Chorioretinitis 11.33 11.15 10 91613 621 42529091
Incorrect product administration duration 11.31 11.15 33 91590 5847 42523865
Poisoning 11.30 11.15 9 91614 14690 42515022
Hypo HDL cholesterolaemia 11.29 11.15 3 91620 9 42529703
Neurilemmoma benign 11.29 11.15 3 91620 9 42529703
Ischaemic stroke 11.27 11.15 19 91604 22214 42507498
Gastrointestinal injury 11.25 11.15 13 91610 1116 42528596
Nightmare 11.24 11.15 23 91600 24989 42504723
Bronchomalacia 11.22 11.15 6 91617 162 42529550
Anxiety 11.21 11.15 334 91289 118226 42411486

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 2284.93 9.70 6720 185922 1493465 108903192
Infective pulmonary exacerbation of cystic fibrosis 1148.43 9.70 546 192096 14225 110382432
Electrocardiogram QT prolonged 800.49 9.70 968 191674 107992 110288665
Asthma 745.65 9.70 1462 191180 248829 110147828
Drug ineffective for unapproved indication 661.64 9.70 855 191787 101983 110294674
Bronchiectasis 589.12 9.70 497 192145 35996 110360661
Abortion incomplete 529.65 9.70 200 192442 2872 110393785
Obstructive airways disorder 492.88 9.70 499 192143 45650 110351007
Full blood count abnormal 473.16 9.70 535 192107 55517 110341140
Drug hypersensitivity 457.25 9.70 1780 190862 452310 109944347
Nasal polyps 403.50 9.70 264 192378 12936 110383721
Haemoptysis 403.23 9.70 557 192085 70797 110325860
Synovitis 401 9.70 18 192624 274074 110122583
Cough 399.40 9.70 1727 190915 459914 109936743
Wheezing 398.37 9.70 1160 191482 254070 110142587
Productive cough 393.75 9.70 711 191931 113594 110283063
Breath sounds abnormal 377.49 9.70 330 192312 25074 110371583
Rhinitis allergic 365.63 9.70 280 192362 17642 110379015
Cystic fibrosis 358.91 9.70 172 192470 4559 110392098
Pemphigus 347.55 9.70 5 192637 214565 110182092
Hand deformity 338.29 9.70 9 192633 218497 110178160
Contraindicated product administered 331.01 9.70 27 192615 248240 110148417
Chronic obstructive pulmonary disease 312.94 9.70 628 192014 108530 110288127
Systemic lupus erythematosus 295.54 9.70 45 192597 254293 110142364
Completed suicide 290.70 9.70 39 192603 242342 110154315
Asthma-chronic obstructive pulmonary disease overlap syndrome 281.41 9.70 161 192481 6183 110390474
Joint swelling 279.99 9.70 217 192425 442628 109954029
Anti-cyclic citrullinated peptide antibody positive 279.82 9.70 8 192634 181976 110214681
Helicobacter infection 279.64 9.70 8 192634 181869 110214788
Glossodynia 277.82 9.70 31 192611 221973 110174684
Drug interaction 253.75 9.70 1614 191028 498569 109898088
Sputum discoloured 251.72 9.70 276 192366 27669 110368988
Arthropathy 245.04 9.70 97 192545 287425 110109232
Long QT syndrome 243.91 9.70 153 192489 6965 110389692
Wound 237.50 9.70 58 192584 234379 110162278
Sleep disorder due to a general medical condition 236.66 9.70 367 192275 51745 110344912
Alopecia 236.58 9.70 174 192468 364579 110032078
Pericarditis 236.54 9.70 47 192595 219067 110177590
Therapeutic product effect decreased 235.05 9.70 67 192575 244249 110152408
Total lung capacity increased 222.12 9.70 128 192514 4984 110391673
Pulmonary function test abnormal 222.07 9.70 127 192515 4873 110391784
Chronic sinusitis 221.19 9.70 245 192397 24839 110371818
Forced expiratory volume decreased 219.94 9.70 183 192459 12993 110383664
Product use in unapproved indication 219.68 9.70 1432 191210 445945 109950712
Dyspnoea 210.16 9.70 2890 189752 1103982 109292675
Rheumatoid factor positive 205.31 9.70 5 192637 131635 110265022
Hypoxia 204.10 9.70 591 192051 128924 110267733
Mobility decreased 202.44 9.70 80 192562 237342 110159315
Arthralgia 202.03 9.70 690 191952 778942 109617715
Rheumatoid arthritis 198.07 9.70 140 192502 299473 110097184
Eosinophilia 192.60 9.70 355 192287 57581 110339076
Pulmonary vasculitis 190.30 9.70 127 192515 6433 110390224
Irritable bowel syndrome 188.58 9.70 30 192612 164185 110232472
Drug resistance 188.12 9.70 346 192296 56028 110340629
Drug abuse 187.45 9.70 40 192602 177371 110219286
Swelling 186.19 9.70 202 192440 350839 110045818
Respiratory failure 183.79 9.70 803 191839 214529 110182128
Immune reconstitution inflammatory syndrome 183.42 9.70 181 192461 16045 110380612
Rheumatic fever 182.71 9.70 7 192635 122572 110274085
Drug ineffective 181.64 9.70 3680 188962 1516860 108879797
Confusional state 179.18 9.70 340 192302 468340 109928317
Folliculitis 178.77 9.70 37 192605 167616 110229041
Joint range of motion decreased 174.89 9.70 9 192633 121823 110274834
Pathogen resistance 174.04 9.70 183 192459 17489 110379168
Stomatitis 173.77 9.70 130 192512 270112 110126545
Pulmonary function test decreased 171.07 9.70 133 192509 8567 110388090
Mycobacterium avium complex infection 166.22 9.70 112 192530 5765 110390892
Upper-airway cough syndrome 164.78 9.70 169 192473 15688 110380969
Impaired healing 161.69 9.70 70 192572 196647 110200010
Condition aggravated 161.50 9.70 1972 190670 732864 109663793
Congenital hiatus hernia 159.83 9.70 112 192530 6147 110390510
Therapeutic product effect incomplete 156.09 9.70 787 191855 223018 110173639
Vaginal flatulence 155.30 9.70 145 192497 11999 110384658
Sleep disorder due to general medical condition, insomnia type 154.22 9.70 7 192635 105636 110291021
Type 2 diabetes mellitus 153.92 9.70 58 192584 177174 110219483
Vasculitis 152.31 9.70 245 192397 35628 110361029
Premature delivery 152.22 9.70 225 192417 30407 110366250
Fall 151.53 9.70 541 192101 602941 109793716
C-reactive protein abnormal 150.48 9.70 23 192619 129672 110266985
Neuritis 149.60 9.70 115 192527 7284 110389373
Female genital tract fistula 146.77 9.70 162 192480 16357 110380300
Chest X-ray abnormal 146.09 9.70 120 192522 8367 110388290
Total lung capacity abnormal 145.80 9.70 94 192548 4489 110392168
Psoriatic arthropathy 142.22 9.70 83 192559 196678 110199979
Fibromyalgia 141.76 9.70 60 192582 170849 110225808
Pulmonary alveolar haemorrhage 141.30 9.70 175 192467 19975 110376682
Ototoxicity 139.55 9.70 88 192554 4043 110392614
Chest discomfort 138.30 9.70 635 192007 173213 110223444
Torsade de pointes 137.61 9.70 183 192459 22417 110374240
Proctitis 136.76 9.70 158 192484 16769 110379888
Oral candidiasis 136.04 9.70 264 192378 44496 110352161
Fatigue 135.66 9.70 1410 191232 1214548 109182109
Peripheral swelling 133.56 9.70 318 192324 403716 109992941
Respiratory symptom 133.54 9.70 147 192495 14798 110381859
Macular degeneration 132.83 9.70 176 192466 21483 110375174
Sarcoidosis 132.41 9.70 135 192507 12444 110384213
Eosinophilic granulomatosis with polyangiitis 131.69 9.70 125 192517 10561 110386096
Malignant neoplasm progression 131.41 9.70 70 192572 174497 110222160
Paraesthesia oral 129.56 9.70 220 192422 33451 110363206
Cholecystitis chronic 128.41 9.70 117 192525 9383 110387274
Vaginal discharge 126.33 9.70 156 192486 17752 110378905
Ear pruritus 125.69 9.70 103 192539 7157 110389500
Acute respiratory distress syndrome 123.48 9.70 281 192361 52917 110343740
Transaminases increased 122.60 9.70 312 192330 63078 110333579
Bursitis 122.40 9.70 37 192605 129881 110266776
Toxicity to various agents 121.76 9.70 429 192213 480126 109916531
Pneumonia 118.47 9.70 2164 190478 874550 109522107
Abdominal discomfort 117.10 9.70 327 192315 393531 110003126
Malignant melanoma in situ 116.03 9.70 74 192568 3468 110393189
Blister 115.95 9.70 135 192507 227241 110169416
Stevens-Johnson syndrome 115.89 9.70 254 192388 46647 110350010
Lip dry 115.53 9.70 18 192624 100065 110296592
Photodermatosis 115.40 9.70 50 192592 1041 110395616
Radiculopathy 115.32 9.70 155 192487 19181 110377476
Wound infection 109.89 9.70 18 192624 96447 110300210
Gait inability 109.73 9.70 50 192592 136326 110260331
Spirometry abnormal 108.01 9.70 84 192558 5413 110391244
Infusion related reaction 107.08 9.70 325 192317 380837 110015820
Conjunctivitis allergic 106.92 9.70 92 192550 6839 110389818
Dysphonia 104.08 9.70 330 192312 75599 110321058
Dry mouth 103.81 9.70 117 192525 199831 110196826
Bronchopulmonary aspergillosis allergic 102.76 9.70 98 192544 8328 110388329
Solar lentigo 102.39 9.70 51 192591 1473 110395184
Bronchopulmonary aspergillosis 101.78 9.70 185 192457 29678 110366979
Somnolence 101.56 9.70 230 192412 297219 110099438
Hypoaesthesia 100.12 9.70 252 192390 313971 110082686
Rales 99.65 9.70 165 192477 24574 110372083
Musculoskeletal stiffness 96.65 9.70 215 192427 279607 110117050
Neurological symptom 95.97 9.70 127 192515 15481 110381176
Hypertransaminasaemia 95.33 9.70 160 192482 24095 110372562
Ill-defined disorder 95.07 9.70 80 192562 156773 110239884
Blood cholesterol increased 94.97 9.70 109 192533 184676 110211981
General physical health deterioration 94.62 9.70 400 192242 424895 109971762
Lung opacity 94.53 9.70 109 192533 11543 110385114
Mite allergy 93.55 9.70 79 192563 5724 110390933
Intentional overdose 92.78 9.70 58 192584 132443 110264214
Dust allergy 91.24 9.70 79 192563 5922 110390735
Febrile neutropenia 89.02 9.70 270 192372 316497 110080160
Peripheral venous disease 88.76 9.70 19 192623 84098 110312559
Toxic epidermal necrolysis 88.48 9.70 258 192384 56469 110340188
Sputum increased 88.03 9.70 76 192566 5675 110390982
Mycotic allergy 87.75 9.70 77 192565 5877 110390780
Musculoskeletal pain 87.69 9.70 114 192528 182909 110213748
Swelling face 87.02 9.70 355 192287 91966 110304691
Procedural pain 86.04 9.70 191 192451 35374 110361283
Contusion 85.85 9.70 173 192469 233188 110163469
Mycobacterial infection 85.71 9.70 67 192575 4350 110392307
Drug effective for unapproved indication 85.15 9.70 114 192528 14053 110382604
Lip oedema 84.46 9.70 84 192558 7516 110389141
Haemorrhage 83.55 9.70 388 192254 106304 110290353
Nasal congestion 83.38 9.70 366 192276 97916 110298741
Inflammation 83.04 9.70 130 192512 193108 110203549
Prescribed overdose 82.39 9.70 25 192617 87556 110309101
Deafness neurosensory 81.45 9.70 92 192550 9527 110387130
Acute respiratory failure 81.19 9.70 302 192340 74958 110321699
Grip strength decreased 80.83 9.70 20 192622 80154 110316503
Deafness 80.51 9.70 157 192485 26552 110370105
Discomfort 79.99 9.70 158 192484 214549 110182108
Lower limb fracture 79.54 9.70 17 192625 75331 110321326
Benign prostatic hyperplasia 79.41 9.70 126 192516 18108 110378549
Upper respiratory tract infection 79.31 9.70 444 192198 130884 110265773
Jaundice cholestatic 77.96 9.70 111 192531 14497 110382160
Death 77.81 9.70 810 191832 698059 109698598
Dysplastic naevus 77.26 9.70 35 192607 813 110395844
Blood lactic acid increased 76.87 9.70 115 192527 15706 110380951
Loss of personal independence in daily activities 76.37 9.70 485 192157 149535 110247122
Nail disorder 75.26 9.70 7 192635 57928 110338729
Overdose 74.84 9.70 187 192455 233607 110163050
Emotional distress 74.84 9.70 209 192433 44638 110352019
Drug reaction with eosinophilia and systemic symptoms 74.48 9.70 312 192330 81783 110314874
Cystic fibrosis respiratory infection suppression 74.16 9.70 29 192613 460 110396197
Aspergillus infection 74.10 9.70 148 192494 25468 110371189
Hypomania 73.73 9.70 90 192552 10120 110386537
Antineutrophil cytoplasmic antibody positive 73.52 9.70 65 192577 5011 110391646
Neutropenia 72.84 9.70 370 192272 374250 110022407
Factor V inhibition 72.38 9.70 27 192615 374 110396283
Cardiac murmur 72.09 9.70 143 192499 24485 110372172
Hepatic enzyme increased 71.83 9.70 301 192341 320591 110076066
Muscular weakness 71.80 9.70 209 192433 248259 110148398
C-reactive protein increased 71.56 9.70 172 192470 217747 110178910
Platelet count increased 71.26 9.70 148 192494 26186 110370471
Dizziness 71.03 9.70 826 191816 697367 109699290
Total lung capacity decreased 70.64 9.70 74 192568 7040 110389617
Eosinophil count abnormal 69.39 9.70 35 192607 1039 110395618
Bronchitis 68.73 9.70 489 192153 156543 110240114
Cholelithiasis 67.99 9.70 254 192388 63168 110333489
Impaired quality of life 67.93 9.70 157 192485 29860 110366797
Bone erosion 67.91 9.70 3 192639 46368 110350289
Adverse event 67.79 9.70 54 192588 108755 110287902
Blepharospasm 67.73 9.70 8 192634 54843 110341814
Mucormycosis 67.70 9.70 88 192554 10540 110386117
Road traffic accident 67.28 9.70 53 192589 107345 110289312
Infective exacerbation of bronchiectasis 66.91 9.70 32 192610 844 110395813
Pseudomonas infection 66.72 9.70 149 192493 27704 110368953
Autoimmune disorder 66.67 9.70 16 192626 65467 110331190
Hepatotoxicity 66.38 9.70 252 192390 63148 110333509
Pneumatosis intestinalis 66.21 9.70 78 192564 8451 110388206
Acute generalised exanthematous pustulosis 66.09 9.70 128 192514 21536 110375121
Pneumomediastinum 66.07 9.70 61 192581 4975 110391682
Osteoarthritis 65.79 9.70 137 192505 182486 110214171
Sciatica 65.30 9.70 40 192602 92359 110304298
Decreased appetite 64.83 9.70 524 192118 475322 109921335
Dyspnoea exertional 63.62 9.70 353 192289 103707 110292950
Vanishing bile duct syndrome 63.53 9.70 49 192593 3119 110393538
Dislocation of vertebra 63.47 9.70 3 192639 43718 110352939
Weight increased 63.37 9.70 449 192193 419195 109977462
Atypical mycobacterial infection 63.33 9.70 46 192596 2672 110393985
Swollen tongue 63.26 9.70 240 192402 60122 110336535
Stenotrophomonas infection 61.89 9.70 63 192579 5795 110390862
Sedation 61.84 9.70 22 192620 69661 110326996
Coma 61.13 9.70 69 192573 117800 110278857
Angioedema 60.79 9.70 335 192307 98165 110298492
Onychomadesis 60.72 9.70 5 192637 45658 110350999
Lung transplant rejection 59.94 9.70 39 192603 1892 110394765
Intentional product use issue 58.97 9.70 227 192415 247679 110148978
Biliary dyskinesia 58.76 9.70 42 192600 2379 110394278
Bronchial wall thickening 58.69 9.70 47 192595 3160 110393497
Myelosuppression 58.54 9.70 47 192595 94293 110302364
Knee arthroplasty 58.50 9.70 20 192622 64928 110331729
Pneumothorax 57.46 9.70 163 192479 35122 110361535
Epilepsy 57.24 9.70 54 192588 100155 110296502
Hypertension 56.38 9.70 592 192050 509492 109887165
Actinic keratosis 55.88 9.70 65 192577 6948 110389709
Rhinorrhoea 55.43 9.70 337 192305 102329 110294328
Tinnitus 54.84 9.70 230 192412 60310 110336347
Mycobacterium abscessus infection 54.29 9.70 35 192607 1671 110394986
Pulmonary embolism 54.23 9.70 592 192050 213882 110182775
Lung neoplasm malignant 53.82 9.70 155 192487 33687 110362970
Respiration abnormal 53.03 9.70 75 192567 9734 110386923
Micturition urgency 52.77 9.70 109 192533 19211 110377446
Rash maculo-papular 52.38 9.70 262 192380 73960 110322697
Prescribed underdose 52.26 9.70 24 192618 65150 110331507
Gastrooesophageal reflux disease 52.25 9.70 511 192131 179465 110217192
Parathyroid gland enlargement 51.68 9.70 18 192624 202 110396455
Influenza 51.50 9.70 485 192157 168616 110228041
Hepatitis 51.43 9.70 300 192342 89754 110306903
Oedema 51.40 9.70 190 192452 209786 110186871
Hypercapnia 51.22 9.70 79 192563 11080 110385577
Suicide attempt 50.97 9.70 63 192579 103331 110293326
Lupus-like syndrome 50.24 9.70 6 192636 40786 110355871
Underdose 50.04 9.70 24 192618 63530 110333127
Cholestasis 49.30 9.70 233 192409 64285 110332372
Eye pruritus 49.14 9.70 147 192495 32628 110364029
Hepatitis acute 49.07 9.70 104 192538 18662 110377995
Alanine aminotransferase increased 48.66 9.70 512 192130 183261 110213396
Memory impairment 48.35 9.70 178 192464 196766 110199891
COVID-19 treatment 48.26 9.70 21 192621 442 110396215
Heart sounds 48.01 9.70 28 192614 1115 110395542
Hepatitis cholestatic 47.85 9.70 99 192543 17467 110379190
Lacrimation increased 47.53 9.70 140 192502 30810 110365847
Cystic fibrosis related diabetes 47.33 9.70 17 192625 210 110396447
Lung diffusion disorder 46.59 9.70 18 192624 276 110396381
No adverse event 46.14 9.70 252 192390 73587 110323070
COVID-19 pneumonia 46.01 9.70 156 192486 36987 110359670
Hip arthroplasty 45.61 9.70 20 192622 55793 110340864
Myasthenia gravis crisis 45.25 9.70 32 192610 1782 110394875
Capillaritis 45.18 9.70 36 192606 2403 110394254
Atypical mycobacterium test positive 45.03 9.70 13 192629 74 110396583
Symmetrical drug-related intertriginous and flexural exanthema 43.96 9.70 32 192610 1865 110394792
Pulmonary mass 43.89 9.70 154 192488 37147 110359510
Oropharyngeal gonococcal infection 43.64 9.70 10 192632 17 110396640
Foot deformity 43.54 9.70 15 192627 48465 110348192
Adverse drug reaction 43.47 9.70 73 192569 105486 110291171
Rhinocerebral mucormycosis 43.12 9.70 29 192613 1488 110395169
Prolonged expiration 42.52 9.70 29 192613 1523 110395134
Migraine 42.22 9.70 155 192487 171497 110225160
Normochromic normocytic anaemia 42.12 9.70 79 192563 12978 110383679
Pulmonary cavitation 41.97 9.70 33 192609 2161 110394496
Sneezing 41.10 9.70 136 192506 31848 110364809
Obliterative bronchiolitis 41.09 9.70 41 192601 3682 110392975
Hepatocellular injury 40.99 9.70 186 192456 50456 110346201
Product packaging quantity issue 40.90 9.70 30 192612 1769 110394888
Neutrophil count decreased 40.85 9.70 94 192548 120847 110275810
Product use issue 40.70 9.70 347 192295 311348 110085309
Platelet count decreased 40.67 9.70 235 192407 230208 110166449
Treatment failure 40.67 9.70 299 192343 276935 110119722
Pneumonia bacterial 40.53 9.70 119 192523 26142 110370515
Cryptococcosis 40.42 9.70 45 192597 4586 110392071
Mucocutaneous disorder 40.33 9.70 15 192627 206 110396451
Dehydration 40.27 9.70 303 192339 279208 110117449
Asthenia 40.23 9.70 904 191738 688095 109708562
Ventilation perfusion mismatch 40.17 9.70 22 192620 775 110395882
Injection site reaction 40.11 9.70 58 192584 89012 110307645
Upper respiratory fungal infection 40.10 9.70 18 192624 409 110396248
Rash erythematous 40.06 9.70 262 192380 81570 110315087
Deafness bilateral 39.91 9.70 35 192607 2669 110393988
Gait disturbance 39.88 9.70 302 192340 277906 110118751
Disseminated mycobacterium avium complex infection 39.80 9.70 19 192623 499 110396158
Hyponatraemia 39.47 9.70 220 192422 217433 110179224
Bronchial hyperreactivity 39.07 9.70 39 192603 3505 110393152
Lung transplant 38.83 9.70 47 192595 5239 110391418
Jarisch-Herxheimer reaction 38.81 9.70 25 192617 1192 110395465
Prostate cancer 38.70 9.70 9 192633 37632 110359025
Hypofibrinogenaemia 38.11 9.70 33 192609 2474 110394183
Eosinophil count increased 37.99 9.70 101 192541 20957 110375700
Forced expiratory volume 37.95 9.70 12 192630 97 110396560
Distal intestinal obstruction syndrome 37.57 9.70 23 192619 1002 110395655
Cardiac arrest 37.12 9.70 514 192128 196239 110200418
Hypertriglyceridaemia 37.11 9.70 85 192557 16069 110380588
Arteriosclerosis coronary artery 37.04 9.70 112 192530 25006 110371651
Emphysema 36.91 9.70 96 192546 19660 110376997
Disseminated strongyloidiasis 36.88 9.70 19 192623 590 110396067
Respiratory tract infection 36.72 9.70 232 192410 71385 110325272
Drug tolerance decreased 36.66 9.70 3 192639 27537 110369120
Leukocytosis 36.57 9.70 188 192454 53640 110343017
Cognitive disorder 36.52 9.70 60 192582 87451 110309206
Lung infiltration 36.49 9.70 110 192532 24518 110372139
Taste disorder 36.45 9.70 36 192606 65351 110331306
Hilar lymphadenopathy 36.41 9.70 31 192611 2271 110394386
Hallucinations, mixed 36.39 9.70 59 192583 8634 110388023
Amnesia 36.35 9.70 81 192561 105327 110291330
Pneumothorax spontaneous 36.21 9.70 28 192614 1789 110394868
Coeliac disease 36.05 9.70 15 192627 43172 110353485
Metastases to bone 35.40 9.70 6 192636 31366 110365291
Oropharyngeal pain 35.39 9.70 376 192266 134900 110261757
Respiratory distress 35.24 9.70 223 192419 68651 110328006
Exostosis 35.20 9.70 18 192624 45938 110350719
Pharyngeal erythema 35.15 9.70 30 192612 2205 110394452
Bronchomalacia 35.13 9.70 15 192627 301 110396356
Bronchiolitis obliterans syndrome 34.65 9.70 19 192623 671 110395986
Lung disorder 34.63 9.70 472 192170 179575 110217082
Multiple organ dysfunction syndrome 34.39 9.70 410 192232 151300 110245357
Tachypnoea 34.39 9.70 148 192494 39247 110357410
Urinary tract infection 34.28 9.70 383 192259 325899 110070758
Arteriosclerosis 34.26 9.70 108 192534 24659 110371998
Pleuritic pain 33.90 9.70 82 192560 16058 110380599
Hyperbilirubinaemia 33.84 9.70 124 192518 30547 110366110
Hepatic cytolysis 33.80 9.70 187 192455 54866 110341791
Infantile vomiting 33.78 9.70 10 192632 63 110396594
Night sweats 33.60 9.70 120 192522 133863 110262794
Depressed level of consciousness 33.48 9.70 93 192549 112185 110284472
Sopor 33.36 9.70 11 192631 36535 110360122
Hypokalaemia 33.30 9.70 184 192458 182264 110214393
HIV associated nephropathy 33.17 9.70 15 192627 347 110396310
Liver injury 33.07 9.70 142 192500 150271 110246386
Flank pain 33.04 9.70 102 192540 23028 110373629
Dysarthria 32.98 9.70 60 192582 84061 110312596
Graft versus host disease in lung 32.94 9.70 23 192619 1255 110395402
Bacterial disease carrier 32.75 9.70 29 192613 2240 110394417
Cardiac failure 32.75 9.70 192 192450 187434 110209223
Seizure 32.70 9.70 238 192404 220947 110175710
Intentional product misuse 32.69 9.70 120 192522 132784 110263873
Incorrect route of product administration 32.67 9.70 38 192604 64023 110332634
Walking aid user 32.65 9.70 3 192639 25072 110371585
Muscle spasticity 32.45 9.70 11 192631 35904 110360753
Cystic fibrosis pancreatic 32.14 9.70 9 192633 45 110396612
Auscultation 32.13 9.70 6 192636 0 110396657
Sinobronchitis 32.00 9.70 16 192626 466 110396191
Myoclonic dystonia 31.82 9.70 10 192632 79 110396578
Tachyarrhythmia 31.81 9.70 54 192588 8207 110388450
Gastrointestinal disorder 31.74 9.70 269 192373 241683 110154974
Methaemoglobinaemia 31.50 9.70 57 192585 9111 110387546
Rhonchi 31.29 9.70 39 192603 4479 110392178
Gallbladder disorder 31.22 9.70 94 192548 20935 110375722
Schizophrenia 30.95 9.70 96 192546 21730 110374927
Hypotension 30.63 9.70 687 191955 523162 109873495
Live birth 30.55 9.70 46 192596 69438 110327219
Fluid retention 30.49 9.70 75 192567 94232 110302425
Neck pain 30.40 9.70 111 192531 123019 110273638
Viral infection 30.32 9.70 177 192465 52962 110343695
HIV infection 30.24 9.70 22 192620 1281 110395376
Back injury 30.18 9.70 23 192619 47376 110349281
Biphasic mesothelioma 29.84 9.70 9 192633 61 110396596
Osteonecrosis of jaw 29.69 9.70 24 192618 47993 110348664
Middle lobe syndrome 29.63 9.70 8 192634 34 110396623
Photosensitivity reaction 29.55 9.70 105 192537 25484 110371173
Bronchial secretion retention 29.54 9.70 40 192602 4984 110391673
Medication error 29.43 9.70 90 192552 105276 110291381
Sputum retention 29.41 9.70 22 192620 1337 110395320
Mixed liver injury 29.36 9.70 65 192577 12014 110384643
White blood cell count decreased 29.21 9.70 257 192385 229133 110167524
Mucosal inflammation 29.14 9.70 79 192563 96062 110300595
Joint stiffness 29.10 9.70 45 192597 67198 110329459
Cryptococcal meningoencephalitis 29.04 9.70 14 192628 376 110396281
Pain in extremity 29.00 9.70 637 192005 486481 109910176
Orthostatic hypotension 28.99 9.70 44 192598 66205 110330452
Mycoplasma infection 28.86 9.70 22 192620 1376 110395281
Cystic fibrosis lung 28.63 9.70 11 192631 166 110396491
Pneumonia pseudomonal 28.62 9.70 49 192593 7497 110389160
Drug-induced liver injury 28.32 9.70 327 192315 119740 110276917
Depression 28.23 9.70 386 192256 316949 110079708
Breast cancer 28.20 9.70 16 192626 38526 110358131
Blood potassium decreased 28.17 9.70 176 192466 53938 110342719
Deafness unilateral 28.14 9.70 37 192605 4482 110392175
Liver disorder 27.89 9.70 140 192502 142103 110254554
Odynophagia 27.88 9.70 70 192572 14031 110382626
Urethritis mycoplasmal 27.81 9.70 7 192635 21 110396636
Pneumococcal infection 27.76 9.70 24 192618 1795 110394862
Gastrointestinal haemorrhage 27.51 9.70 172 192470 165346 110231311
Muscle spasms 27.46 9.70 331 192311 277826 110118831
Immunodeficiency common variable 27.42 9.70 16 192626 638 110396019
NPM1 gene mutation 27.38 9.70 10 192632 130 110396527
Oral blood blister 27.32 9.70 9 192633 84 110396573
Palmar-plantar erythrodysaesthesia syndrome 27.30 9.70 19 192623 41006 110355651
Alveolitis 27.11 9.70 36 192606 4403 110392254
Rhinovirus infection 27.05 9.70 62 192580 11727 110384930
Factor V deficiency 27.04 9.70 9 192633 87 110396570
Sleep disorder 26.89 9.70 219 192423 198425 110198232
Secretion discharge 26.84 9.70 87 192555 20157 110376500
Agranulocytosis 26.81 9.70 192 192450 61568 110335089
Drug intolerance 26.42 9.70 524 192118 405988 109990669
Delirium 26.41 9.70 133 192509 134892 110261765
Organising pneumonia 26.39 9.70 69 192573 14174 110382483
Ventricular tachycardia 26.25 9.70 163 192479 49846 110346811
Blood bilirubin increased 26.25 9.70 224 192418 75748 110320909
Eosinophilic pneumonia 26.20 9.70 46 192596 7181 110389476
Staphylococcal infection 26.18 9.70 210 192432 69734 110326923
Pain 26.06 9.70 1379 191263 953576 109443081
Atypical mycobacterial lower respiratory tract infection 26.02 9.70 12 192630 291 110396366
Fungal disease carrier 25.96 9.70 14 192628 478 110396179
Oesophageal injury 25.64 9.70 12 192630 301 110396356
Red blood cell sedimentation rate increased 25.53 9.70 62 192580 78240 110318417
Eosinophilic pneumonia acute 25.48 9.70 22 192620 1643 110395014
Respiratory disorder 25.47 9.70 212 192430 71170 110325487
Metastases to liver 25.45 9.70 15 192627 35371 110361286
Bronchial anastomosis complication 25.07 9.70 9 192633 111 110396546
Balance disorder 25.03 9.70 111 192531 116449 110280208
Erythema 25.03 9.70 675 191967 290772 110105885
Myocardial infarction 24.99 9.70 214 192428 191869 110204788
Rheumatoid nodule 24.96 9.70 3 192639 20293 110376364
Sinus polyp degeneration 24.94 9.70 8 192634 68 110396589
Hepatomegaly 24.84 9.70 88 192554 21326 110375331
Pneumonia mycoplasmal 24.63 9.70 22 192620 1719 110394938
Pyrexia 24.60 9.70 1849 190793 896416 109500241
Arthritis 24.44 9.70 181 192461 167405 110229252
Pelvic inflammatory disease 24.43 9.70 21 192621 1559 110395098
Aspartate aminotransferase increased 24.41 9.70 403 192239 159533 110237124
Abdominal wall haematoma 24.26 9.70 39 192603 5666 110390991
Pancreatitis acute 24.24 9.70 184 192458 60090 110336567
Ulcer haemorrhage 24.01 9.70 5 192637 22566 110374091
Erythema multiforme 23.87 9.70 86 192556 21011 110375646
Chronic kidney disease 23.81 9.70 220 192422 76071 110320586
Device expulsion 23.81 9.70 12 192630 30879 110365778
Injection site haemorrhage 23.75 9.70 14 192628 33014 110363643
Lung hyperinflation 23.60 9.70 24 192618 2205 110394452
Disseminated cryptococcosis 23.50 9.70 26 192616 2631 110394026
Injection site erythema 23.18 9.70 85 192557 94091 110302566
Dystonia 23.15 9.70 8 192634 25797 110370860
Miosis 23.12 9.70 5 192637 21978 110374679
Cerebral infarction 23.10 9.70 34 192608 51804 110344853
Primary adrenal insufficiency 22.87 9.70 14 192628 610 110396047
Rash maculovesicular 22.77 9.70 7 192635 51 110396606
Respiratory syncytial virus infection 22.70 9.70 66 192576 14418 110382239
Bladder cancer 22.64 9.70 4 192638 20288 110376369
Lung neoplasm 22.57 9.70 46 192596 8030 110388627
Blood calcium increased 22.55 9.70 76 192566 17964 110378693
Blood test abnormal 22.46 9.70 104 192538 28450 110368207
FEV1/FVC ratio abnormal 22.42 9.70 7 192635 54 110396603
Exposure during pregnancy 22.37 9.70 413 192229 167011 110229646
Frequent bowel movements 22.35 9.70 206 192436 71184 110325473
Pneumonia necrotising 22.32 9.70 21 192621 1754 110394903
Pseudomembranous colitis 22.29 9.70 40 192602 6351 110390306
Pneumonia aspiration 22.25 9.70 70 192572 81163 110315494
Paranasal sinus discomfort 22.23 9.70 40 192602 6365 110390292
Appetite disorder 22.00 9.70 51 192591 9718 110386939
Psoriasis 21.98 9.70 148 192494 139845 110256812
Neoplasm progression 21.98 9.70 50 192592 64545 110332112
Injection site pain 21.92 9.70 201 192441 177721 110218936
Basal cell carcinoma 21.87 9.70 28 192614 45242 110351415
Genital erosion 21.85 9.70 15 192627 796 110395861
Endometritis 21.60 9.70 16 192626 958 110395699
Drug use disorder 21.43 9.70 3 192639 18071 110378586
Diabetic ketoacidosis 21.39 9.70 25 192617 42033 110354624
Multiple sclerosis relapse 21.38 9.70 34 192608 50206 110346451
Red blood cell sedimentation rate abnormal 21.30 9.70 8 192634 24501 110372156
Mechanical urticaria 21.16 9.70 13 192629 570 110396087
Extrapyramidal disorder 21.10 9.70 12 192630 28855 110367802
Pharyngeal enanthema 21.09 9.70 7 192635 67 110396590
Increased bronchial secretion 21.07 9.70 30 192612 3918 110392739
Hepatic cirrhosis 20.92 9.70 55 192587 67571 110329086
Immunosuppressant drug level increased 20.91 9.70 56 192586 11668 110384989
Bronchial disorder 20.91 9.70 25 192617 2751 110393906
Obesity 20.85 9.70 114 192528 113237 110283420
Mononeuropathy 20.77 9.70 11 192631 362 110396295
Pancreatic failure 20.76 9.70 23 192619 2331 110394326
Rash morbilliform 20.71 9.70 44 192598 7907 110388750
Urosepsis 20.69 9.70 14 192628 30661 110365996
Blood pressure increased 20.63 9.70 321 192321 258052 110138605
Inguinal hernia repair 20.50 9.70 11 192631 372 110396285
Febrile bone marrow aplasia 20.48 9.70 3 192639 17462 110379195
Forced vital capacity decreased 20.47 9.70 21 192621 1949 110394708
Iris transillumination defect 20.32 9.70 9 192633 198 110396459
Blood immunoglobulin E increased 20.18 9.70 42 192600 7440 110389217
Anhedonia 20.18 9.70 66 192576 15362 110381295
Vitamin K deficiency 20.14 9.70 15 192627 906 110395751
Hyperkalaemia 20.12 9.70 146 192496 135650 110261007
Poisoning 20.01 9.70 13 192629 29092 110367565
Drug level increased 19.94 9.70 147 192495 47572 110349085
Coinfection 19.79 9.70 8 192634 139 110396518
Maternal exposure timing unspecified 19.76 9.70 6 192636 21007 110375650
Upper airway necrosis 19.72 9.70 6 192636 42 110396615
Hypogammaglobulinaemia 19.55 9.70 78 192564 19998 110376659
Herpes simplex viraemia 19.52 9.70 13 192629 656 110396001
Macule 19.50 9.70 28 192614 3685 110392972
Drug eruption 19.49 9.70 160 192482 53499 110343158
Cytokine storm 19.46 9.70 18 192624 1472 110395185
Chimerism 19.40 9.70 10 192632 311 110396346
Bacterial infection 19.34 9.70 142 192500 45894 110350763
Granulomatosis with polyangiitis 19.34 9.70 27 192615 3463 110393194
Altered state of consciousness 19.29 9.70 45 192597 57581 110339076
Palatal oedema 19.28 9.70 19 192623 1681 110394976
Toxic optic neuropathy 19.22 9.70 17 192625 1311 110395346
Viral labyrinthitis 19.19 9.70 4 192638 3 110396654
Uterine perforation 19.16 9.70 39 192603 6801 110389856
Haemophilus infection 19.12 9.70 24 192618 2776 110393881
Subcutaneous emphysema 19.02 9.70 23 192619 2561 110394096
Mycobacterium chelonae infection 18.97 9.70 25 192617 3035 110393622
COVID-19 18.93 9.70 560 192082 244500 110152157
Tooth discolouration 18.84 9.70 17 192625 1346 110395311
Colitis 18.76 9.70 266 192376 102057 110294600
Bronchiolitis 18.68 9.70 34 192608 5459 110391198
Sensory loss 18.65 9.70 7 192635 21450 110375207
Andersen-Tawil syndrome 18.65 9.70 4 192638 4 110396653
Middle insomnia 18.65 9.70 78 192564 20424 110376233
Jaundice 18.58 9.70 171 192471 59065 110337592
Respiratory depression 18.56 9.70 17 192625 31984 110364673
Fracture 18.56 9.70 10 192632 24778 110371879
Insomnia 18.55 9.70 482 192160 360108 110036549
Conjunctival hyperaemia 18.46 9.70 35 192607 5796 110390861
Ischaemic stroke 18.45 9.70 27 192615 41236 110355421
Onychomycosis 18.44 9.70 24 192618 38507 110358150
Bifidobacterium infection 18.44 9.70 7 192635 102 110396555
Strongyloidiasis 18.42 9.70 32 192610 4954 110391703
Sinus congestion 18.39 9.70 103 192539 30356 110366301
Empyema 18.34 9.70 34 192608 5536 110391121
Thermal burn 18.32 9.70 42 192600 7946 110388711
Back pain 18.28 9.70 499 192143 370497 110026160
Aspiration 18.27 9.70 103 192539 30430 110366227
Bone density decreased 18.25 9.70 3 192639 16039 110380618
Abortion spontaneous 18.16 9.70 112 192530 34170 110362487
Device malfunction 18.15 9.70 11 192631 25547 110371110
Aphthous ulcer 18.14 9.70 79 192563 21057 110375600
Adverse reaction 18.04 9.70 15 192627 29579 110367078
Restrictive allograft syndrome 18.03 9.70 5 192637 24 110396633
Bacterial pericarditis 18.02 9.70 7 192635 109 110396548
Peak expiratory flow rate abnormal 18.02 9.70 7 192635 109 110396548
Acute hepatic failure 17.99 9.70 117 192525 36351 110360306
Abdominal pain 17.93 9.70 1078 191564 511911 109884746
Lower gastrointestinal haemorrhage 17.89 9.70 5 192637 18481 110378176
Meningism 17.88 9.70 13 192629 756 110395901
Weight decreased 17.78 9.70 991 191651 467066 109929591
SJS-TEN overlap 17.73 9.70 19 192623 1855 110394802
Hepatosplenomegaly 17.69 9.70 38 192604 6881 110389776
Noninfective conjunctivitis 17.67 9.70 6 192636 62 110396595
Small intestinal obstruction 17.65 9.70 18 192624 32195 110364462
Nodule 17.53 9.70 107 192535 32524 110364133
Localised infection 17.51 9.70 30 192612 43018 110353639
Colitis ulcerative 17.49 9.70 209 192433 77154 110319503
Gallbladder cholesterolosis 17.44 9.70 12 192630 639 110396018
Skin disorder 17.37 9.70 30 192612 42883 110353774
Skin ulcer 17.32 9.70 55 192587 63590 110333067
Second primary malignancy 17.28 9.70 5 192637 18063 110378594
Nasopharyngitis 17.28 9.70 539 192103 393822 110002835
Carbon dioxide increased 17.27 9.70 23 192619 2821 110393836
Ascites 17.26 9.70 93 192549 92715 110303942
Therapeutic response decreased 17.23 9.70 98 192544 96401 110300256
Blood uric acid increased 17.15 9.70 8 192634 21521 110375136
Pulmonary infarction 17.14 9.70 28 192614 4123 110392534
Hypoglycaemia 17.12 9.70 125 192517 115979 110280678
Kawasaki's disease 17.04 9.70 4 192638 8 110396649
Paraesthesia 16.90 9.70 360 192282 276161 110120496
Squamous cell carcinoma of skin 16.88 9.70 67 192575 17136 110379521
Illness 16.86 9.70 218 192424 81953 110314704
Blood pressure fluctuation 16.83 9.70 70 192572 74754 110321903
Rhabdomyolysis 16.78 9.70 299 192343 120102 110276555
Aphasia 16.75 9.70 50 192592 58947 110337710
Urethral discharge 16.72 9.70 4 192638 9 110396648
Acute kidney injury 16.69 9.70 1304 191338 634126 109762531
Clostridium difficile colitis 16.69 9.70 132 192510 43646 110353011
Joint dislocation 16.67 9.70 21 192621 34169 110362488
Acoustic neuroma 16.65 9.70 9 192633 309 110396348
Gastroenteritis staphylococcal 16.62 9.70 9 192633 310 110396347
Tracheobronchitis 16.54 9.70 22 192620 2694 110393963
Haematotoxicity 16.53 9.70 8 192634 21074 110375583
Oropharyngeal candidiasis 16.51 9.70 19 192623 2007 110394650
Rheumatoid factor 16.48 9.70 11 192631 557 110396100
Penile abscess 16.46 9.70 7 192635 139 110396518
Ear discomfort 16.43 9.70 50 192592 11199 110385458
Injection site swelling 16.40 9.70 54 192588 61736 110334921
Eye swelling 16.28 9.70 106 192536 32942 110363715
Mouth injury 16.28 9.70 15 192627 1220 110395437
Immunosuppressant drug level decreased 16.20 9.70 22 192620 2749 110393908
Muscle rigidity 16.16 9.70 11 192631 24020 110372637
Haematemesis 16.14 9.70 51 192591 59057 110337600
Thoracic cavity drainage test abnormal 16.06 9.70 3 192639 0 110396657
Allergic stomatitis 16.06 9.70 3 192639 0 110396657
Portal hypertensive enteropathy 16.06 9.70 3 192639 0 110396657
Amniotic cavity infection 15.98 9.70 13 192629 894 110395763
Metastases to central nervous system 15.95 9.70 10 192632 22807 110373850
Coronary artery disease 15.91 9.70 193 192449 71497 110325160
Bronchial obstruction 15.85 9.70 23 192619 3056 110393601
Herpes zoster 15.82 9.70 117 192525 108262 110288395
Gallbladder injury 15.74 9.70 15 192627 1273 110395384
Vaginal stricture 15.65 9.70 4 192638 13 110396644
Lower respiratory tract infection 15.59 9.70 314 192328 242792 110153865
Bronchospasm 15.52 9.70 98 192544 30141 110366516
Panniculitis 15.49 9.70 4 192638 15578 110381079
Superinfection bacterial 15.48 9.70 20 192622 2381 110394276
Malabsorption from administration site 15.44 9.70 7 192635 163 110396494
Haemolysis 15.42 9.70 61 192581 15578 110381079
Serum sickness-like reaction 15.39 9.70 12 192630 776 110395881
Blood immunoglobulin G decreased 15.38 9.70 31 192611 5369 110391288
Disorientation 15.35 9.70 67 192575 70604 110326053
Blood glucose increased 15.33 9.70 152 192490 132344 110264313
Crystal arthropathy 15.31 9.70 8 192634 256 110396401
Alveolar proteinosis 15.29 9.70 16 192626 1520 110395137
Mycobacterium test positive 15.28 9.70 11 192631 630 110396027
Humidity intolerance 15.28 9.70 10 192632 490 110396167
Liver function test 15.20 9.70 7 192635 169 110396488
Vaginal cellulitis 15.18 9.70 6 192636 98 110396559
Oral mucosa erosion 15.17 9.70 20 192622 2428 110394229
Rhodococcus infection 15.17 9.70 10 192632 496 110396161
Parkinsonism 15.13 9.70 10 192632 22177 110374480
Eye irritation 15.11 9.70 105 192537 33347 110363310
Pneumonia staphylococcal 15.06 9.70 33 192609 6058 110390599
Psychotic disorder 14.95 9.70 145 192497 50792 110345865
Dysentery 14.95 9.70 15 192627 1356 110395301
Inappropriate schedule of product administration 14.93 9.70 257 192385 203380 110193277
Joint injury 14.93 9.70 120 192522 39874 110356783
Peritonitis 14.91 9.70 21 192621 32586 110364071
Neurotoxicity 14.91 9.70 32 192610 42175 110354482
Suicidal ideation 14.90 9.70 99 192543 93838 110302819
Lip erythema 14.85 9.70 10 192632 514 110396143
Gingival oedema 14.80 9.70 6 192636 105 110396552
Lung consolidation 14.78 9.70 46 192596 10430 110386227
Diverticulitis 14.74 9.70 46 192596 53476 110343181
Enterovirus infection 14.71 9.70 21 192621 2749 110393908
Urinary retention 14.58 9.70 67 192575 69616 110327041
Disturbance in attention 14.58 9.70 57 192585 61938 110334719
Face oedema 14.50 9.70 104 192538 33365 110363292
Cytokine release syndrome 14.47 9.70 68 192574 70238 110326419
Device leakage 14.35 9.70 5 192637 16043 110380614
Exercise tolerance decreased 14.35 9.70 50 192592 12017 110384640
Rash pustular 14.27 9.70 52 192590 12777 110383880
Hyperventilation 14.24 9.70 41 192601 8906 110387751
Skin lesion 14.20 9.70 145 192497 51486 110345171
Haemolytic anaemia 14.16 9.70 73 192569 20847 110375810
HIV viraemia 14.16 9.70 6 192636 118 110396539
Bronchopleural fistula 14.07 9.70 12 192630 881 110395776
Blood alkaline phosphatase increased 14.06 9.70 187 192455 70748 110325909
Respiratory gas exchange disorder 14.01 9.70 12 192630 886 110395771
Pernio-like erythema 13.99 9.70 3 192639 3 110396654
Renal injury 13.87 9.70 67 192575 18646 110378011
Cerebrovascular accident 13.87 9.70 227 192415 181057 110215600
Alcohol intolerance 13.81 9.70 9 192633 438 110396219
Nosocomial infection 13.78 9.70 22 192620 3177 110393480
Infusion site streaking 13.78 9.70 10 192632 580 110396077
Infection 13.77 9.70 504 192138 361696 110034961
Purpura 13.76 9.70 81 192561 24307 110372350
Blood parathyroid hormone decreased 13.72 9.70 3 192639 13086 110383571
Cholinergic rebound syndrome 13.69 9.70 5 192637 65 110396592
Hospitalisation 13.68 9.70 335 192307 142158 110254499
Pleural fistula 13.68 9.70 4 192638 24 110396633
Transient ischaemic attack 13.66 9.70 171 192471 63811 110332846
Hyperaemia 13.66 9.70 24 192618 3749 110392908
Laziness 13.63 9.70 12 192630 920 110395737
Genital ulceration 13.60 9.70 17 192625 1958 110394699
Laryngitis 13.50 9.70 34 192608 42377 110354280
Hepatic necrosis 13.48 9.70 43 192599 9879 110386778
Skin haemorrhage 13.46 9.70 14 192628 24813 110371844
Hepatitis fulminant 13.41 9.70 39 192603 8521 110388136
Spinal cord compression 13.40 9.70 36 192606 7516 110389141
Loss of consciousness 13.36 9.70 251 192391 196055 110200602
Anxiety 13.36 9.70 732 191910 344346 110052311
Hypoacusis 13.36 9.70 106 192536 35085 110361572
Allergic sinusitis 13.35 9.70 16 192626 1765 110394892
Temperature regulation disorder 13.32 9.70 3 192639 12823 110383834
Arterial occlusive disease 13.30 9.70 5 192637 15303 110381354
Head injury 13.29 9.70 35 192607 42982 110353675
Pneumonitis 13.25 9.70 197 192445 76334 110320323
Thrombocytopenic purpura 13.23 9.70 21 192621 3018 110393639
Pigment nephropathy 13.23 9.70 5 192637 72 110396585
Local reaction 13.22 9.70 11 192631 781 110395876
Urinary incontinence 13.21 9.70 42 192600 48545 110348112
Infective chondritis 13.15 9.70 4 192638 28 110396629
Catastrophic reaction 13.15 9.70 4 192638 28 110396629
Vulvovaginal pruritus 13.12 9.70 22 192620 3309 110393348
Spinal pain 13.10 9.70 8 192634 18507 110378150
Pneumonia serratia 13.10 9.70 5 192637 74 110396583
Gonorrhoea 13.01 9.70 7 192635 238 110396419
Feeling hot 12.99 9.70 99 192543 91007 110305650
Vulvovaginal burning sensation 12.97 9.70 17 192625 2052 110394605
Motor dysfunction 12.97 9.70 14 192628 24392 110372265
Product administered to patient of inappropriate age 12.96 9.70 37 192605 7999 110388658
Dementia 12.95 9.70 22 192620 31651 110365006
Staphylococcus test positive 12.94 9.70 35 192607 7335 110389322
Interstitial lung disease 12.92 9.70 168 192474 139166 110257491
Glucose-6-phosphate dehydrogenase deficiency 12.87 9.70 9 192633 492 110396165
Respiratory tract congestion 12.86 9.70 95 192547 30762 110365895
Product prescribing error 12.85 9.70 46 192596 51285 110345372
Bone pain 12.82 9.70 64 192578 65069 110331588
Good syndrome 12.78 9.70 3 192639 6 110396651
Stillbirth 12.77 9.70 25 192617 4239 110392418
CD4 lymphocytes increased 12.68 9.70 8 192634 368 110396289
Akathisia 12.67 9.70 7 192635 17106 110379551
Blood viscosity abnormal 12.64 9.70 7 192635 252 110396405
Laryngeal mass 12.63 9.70 5 192637 82 110396575
Oesophagogastroduodenoscopy 12.57 9.70 7 192635 255 110396402
Multiple-drug resistance 12.55 9.70 51 192591 13184 110383473
Lymphadenopathy 12.53 9.70 168 192474 63667 110332990
Meibomianitis 12.52 9.70 5 192637 84 110396573
Eosinophilic pustular folliculitis 12.52 9.70 6 192636 159 110396498
Gastrointestinal injury 12.50 9.70 16 192626 1887 110394770
Nightmare 12.49 9.70 31 192611 38832 110357825
Atypical mycobacterial lymphadenitis 12.47 9.70 4 192638 34 110396623
Respiratory tract inflammation 12.47 9.70 12 192630 1031 110395626
Haematochezia 12.44 9.70 276 192366 115248 110281409
Virologic failure 12.44 9.70 27 192615 4925 110391732
Procedural anxiety 12.42 9.70 11 192631 850 110395807
Accidental exposure to product 12.39 9.70 45 192597 49963 110346694
Mycoplasma test positive 12.37 9.70 7 192635 263 110396394
Disease recurrence 12.36 9.70 161 192481 60623 110336034
Appendicitis 12.36 9.70 19 192623 28445 110368212
Occupational exposure to air contaminants 12.28 9.70 6 192636 166 110396491
Drug dose omission by device 12.18 9.70 5 192637 14511 110382146
Biopsy colon abnormal 12.16 9.70 5 192637 91 110396566
Post transplant lymphoproliferative disorder 12.13 9.70 6 192636 15607 110381050
Ankylosing spondylitis 12.13 9.70 6 192636 15606 110381051
Hemianopia heteronymous 12.11 9.70 5 192637 92 110396565
Ischaemic cardiomyopathy 12.07 9.70 36 192606 7975 110388682
Drug tolerance 11.97 9.70 7 192635 16578 110380079
Skin fissures 11.95 9.70 15 192627 24443 110372214
Erysipelas 11.94 9.70 4 192638 13154 110383503
Hypo HDL cholesterolaemia 11.92 9.70 3 192639 9 110396648
International normalised ratio increased 11.92 9.70 215 192427 86557 110310100
Intentional self-injury 11.92 9.70 30 192612 37399 110359258
Anal skin tags 11.90 9.70 9 192633 556 110396101
Cutaneous mucormycosis 11.90 9.70 10 192632 720 110395937
Eosinophilic pneumonia chronic 11.87 9.70 9 192633 558 110396099
Substance-induced psychotic disorder 11.87 9.70 28 192614 5396 110391261
Hypophosphataemia 11.85 9.70 25 192617 33157 110363500
Intestinal obstruction 11.85 9.70 50 192592 53177 110343480
Myopia 11.74 9.70 17 192625 2254 110394403
Bradyphrenia 11.68 9.70 3 192639 11725 110384932
Lymphadenopathy mediastinal 11.66 9.70 28 192614 5456 110391201
Injection site warmth 11.66 9.70 8 192634 17397 110379260
Enterobacter infection 11.65 9.70 29 192613 5782 110390875
Henoch-Schonlein purpura 11.64 9.70 22 192620 3635 110393022
Uvulitis 11.64 9.70 4 192638 43 110396614
Nocardiosis 11.62 9.70 34 192608 7452 110389205
Dyshidrotic eczema 11.61 9.70 10 192632 744 110395913
Eyelid oedema 11.57 9.70 55 192587 15207 110381450
Q fever 11.54 9.70 7 192635 300 110396357
Cyanosis 11.52 9.70 90 192552 29651 110367006
Acute sinusitis 11.51 9.70 27 192615 5184 110391473
Injection site bruising 11.51 9.70 48 192594 51215 110345442
Pharyngitis 11.46 9.70 79 192563 25019 110371638
Lymph node palpable 11.45 9.70 6 192636 193 110396464
Metastases to lung 11.42 9.70 14 192628 23049 110373608
Optic neuritis 11.41 9.70 44 192598 11103 110385554
Ecchymosis 11.39 9.70 60 192582 17278 110379379
Photophobia 11.39 9.70 17 192625 25754 110370903
Dizziness exertional 11.38 9.70 10 192632 765 110395892
Anticoagulation drug level above therapeutic 11.35 9.70 25 192617 4605 110392052
Poor feeding infant 11.34 9.70 6 192636 197 110396460
Diffuse panbronchiolitis 11.32 9.70 4 192638 47 110396610
Veillonella infection 11.32 9.70 4 192638 47 110396610
Leukaemoid reaction 11.30 9.70 8 192634 446 110396211
Bulimia nervosa 11.27 9.70 7 192635 313 110396344
Papillary muscle rupture 11.26 9.70 3 192639 12 110396645
Neurilemmoma benign 11.26 9.70 3 192639 12 110396645
Bronchogram abnormal 11.26 9.70 3 192639 12 110396645
Cardiac failure congestive 11.25 9.70 190 192452 150810 110245847
Ischaemic limb pain 11.24 9.70 4 192638 48 110396609
Graft infection 11.23 9.70 10 192632 778 110395879
Haemorrhoids thrombosed 11.23 9.70 7 192635 315 110396342
Osteogenesis imperfecta 11.22 9.70 10 192632 779 110395878
Acute psychosis 11.19 9.70 26 192616 4961 110391696
Haemorrhagic stroke 11.17 9.70 5 192637 13784 110382873
Pancreatic carcinoma 11.13 9.70 6 192636 14866 110381791
Laryngeal pain 11.13 9.70 29 192613 5946 110390711
Depressed mood 11.11 9.70 158 192484 60651 110336006
Cerebral haemorrhage 11.06 9.70 67 192575 64901 110331756
Asthmatic crisis 11.03 9.70 16 192626 2126 110394531
Prostatic specific antigen increased 11.01 9.70 4 192638 12507 110384150
Anosmia 11.00 9.70 47 192595 12425 110384232
Delusional disorder, persecutory type 10.99 9.70 9 192633 625 110396032
Lethargy 10.97 9.70 107 192535 93469 110303188
Autoimmune hepatitis 10.97 9.70 53 192589 14751 110381906
Enthesopathy 10.97 9.70 4 192638 12474 110384183
Blood pressure decreased 10.95 9.70 138 192504 114953 110281704
Hyperaesthesia 10.94 9.70 6 192636 14721 110381936
Clavicle fracture 10.93 9.70 27 192615 5357 110391300
Vascular parkinsonism 10.93 9.70 5 192637 119 110396538
Urticaria 10.92 9.70 669 191973 318188 110078469
Angina bullosa haemorrhagica 10.91 9.70 6 192636 213 110396444
Chromaturia 10.90 9.70 88 192554 29272 110367385
Tardive dyskinesia 10.88 9.70 5 192637 13574 110383083
Breast cancer metastatic 10.87 9.70 3 192639 11178 110385479
Dysstasia 10.85 9.70 26 192616 32960 110363697
Ruptured ectopic pregnancy 10.83 9.70 8 192634 477 110396180
Acid fast bacilli infection 10.79 9.70 6 192636 218 110396439
Nail pitting 10.79 9.70 8 192634 480 110396177
Pneumonia legionella 10.78 9.70 21 192621 3548 110393109
Mucopolysaccharidosis II 10.71 9.70 3 192639 15 110396642
Vaginal abscess 10.71 9.70 8 192634 485 110396172
Disease progression 10.57 9.70 334 192308 243700 110152957
Cystic fibrosis hepatic disease 10.56 9.70 4 192638 58 110396599
Vitamin D increased 10.55 9.70 10 192632 843 110395814
Measles 10.54 9.70 9 192633 662 110395995
Wound complication 10.51 9.70 29 192613 6148 110390509
Bronchoalveolar lavage 10.43 9.70 4 192638 60 110396597
Forced expiratory volume increased 10.42 9.70 5 192637 133 110396524
Sinus pain 10.40 9.70 28 192614 5851 110390806
Visual impairment 10.39 9.70 168 192474 134260 110262397
Syncope 10.34 9.70 271 192371 202265 110194392
Status epilepticus 10.29 9.70 25 192617 31546 110365111
Hypercalcaemia 10.28 9.70 44 192598 46613 110350044
Kidney transplant rejection 10.27 9.70 4 192638 11983 110384674
Mixed deafness 10.26 9.70 3 192639 18 110396639
Conjunctivochalasis 10.26 9.70 3 192639 18 110396639
Gallbladder hypofunction 10.25 9.70 8 192634 518 110396139
Hyperphosphatasaemia 10.25 9.70 5 192637 138 110396519
Pneumonia cytomegaloviral 10.24 9.70 31 192611 6923 110389734
Movement disorder 10.23 9.70 31 192611 36373 110360284
Coronavirus test positive 10.22 9.70 12 192630 1295 110395362
Venoocclusive liver disease 10.18 9.70 7 192635 15200 110381457
Transfusion 10.13 9.70 18 192624 25454 110371203
Pulmonary fibrosis 10.12 9.70 241 192401 101801 110294856
Ureteric perforation 10.12 9.70 3 192639 19 110396638
Pneumopericardium 10.11 9.70 6 192636 247 110396410
Human ehrlichiosis 10.05 9.70 9 192633 706 110395951
Borderline personality disorder 10.04 9.70 11 192631 1101 110395556
Stomatococcal infection 10.04 9.70 7 192635 381 110396276
Joint effusion 10.03 9.70 13 192629 20892 110375765
Musculoskeletal disorder 9.97 9.70 15 192627 22649 110374008
Infection reactivation 9.96 9.70 22 192620 4059 110392598
Hypoxic-ischaemic encephalopathy 9.96 9.70 36 192606 8811 110387846
Antinuclear antibody negative 9.93 9.70 5 192637 148 110396509
Joint warmth 9.92 9.70 15 192627 2067 110394590
Coagulopathy 9.90 9.70 112 192530 40799 110355858
Diverticulum intestinal 9.90 9.70 4 192638 11715 110384942
Hypomagnesaemia 9.89 9.70 63 192579 60307 110336350
Vestibular disorder 9.86 9.70 17 192625 2615 110394042
Mediastinal shift 9.82 9.70 4 192638 71 110396586
Wrong dose 9.78 9.70 17 192625 2632 110394025
Blood pressure diastolic increased 9.76 9.70 11 192631 18796 110377861
Legionella test positive 9.74 9.70 3 192639 22 110396635
Needle issue 9.74 9.70 10 192632 17830 110378827
Choroiditis 9.71 9.70 13 192629 1602 110395055

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01FA10 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Macrolides
ATC J01RA07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J01RA16 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC S01AA26 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
FDA CS M0028311 Macrolides
FDA Chemical/Ingredient N0000007529 Macrolides
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35442 antiparasitic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35718 antifungal agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:78298 environmental contaminant
FDA EPC N0000175935 Macrolide Antimicrobial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents

Related Drugs by ATC class:

J01FA Macrolides 13 drugs
clarithromycindirithromycinerythromycinflurithromycinjosamycinmiocamycinmydecamycinoleandomycinrokitamycinroxithromycinspiramycintelithromycin show all 13 →
J01RA Combinations of antibacterials 18 drugs
amikacincefepimecefiximecefuroximeciprofloxacinfluconazolelevofloxacinmetronidazolenitazoxanidenorfloxacinnystatinofloxacin show all 18 →
S01AA Antibiotics 27 drugs
amikacinampicillinazidamfenicolbacitracinbenzylpenicillincefmenoximecefuroximechloramphenicolchlortetracyclinedibekacindihydrostreptomycinerythromycin show all 27 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Haemophilus Influenzae Acute Otitis Media indication 19021002
Acute gonococcal cervicitis indication 20943002 DOID:10615
Acute gonococcal urethritis indication 29864006
Bacterial blepharitis indication 41446000 DOID:9423
Streptococcal tonsillitis indication 41582007
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Bacterial pneumonia indication 53084003 DOID:874
Haemophilus influenzae pneumonia indication 70036007
Acute bacterial sinusitis indication 75498004
Dacryocystitis indication 85777005 DOID:9938
Bacterial conjunctivitis indication 128350005 DOID:9700
Urethritis due to Chlamydia trachomatis indication 179101003
Pulmonary Mycobacterium avium complex infection indication 186342000
Chlamydial pelvic inflammatory disease indication 188463006
Acute bacterial bronchitis indication 233598009
Pneumococcal pneumonia indication 233607000
Chlamydial pneumonia indication 233609002
Chancroid indication 266143009 DOID:13778
Pelvic inflammatory disease due to Mycoplasma hominis indication 270550006
Streptococcus pyogenes infection indication 302809008
Infective otitis media indication 312218008
Bacterial hordeolum indication 397513003 DOID:9909
Infection due to Staphylococcus aureus indication 406602003
Acute exacerbation of chronic bronchitis indication 425748003
Pneumonia due to Staphylococcus aureus indication 441658007
Moraxella Catarrhalis Acute Otitis Media indication 703469002
Skin and Skin Structure Streptococcus Agalactiae Infection indication
Pelvic Inflammatory Disease with Neisseria Gonorrhea indication
Chlamydia Cervicitis indication
Moraxella Catarrhalis Pneumonia indication
Pneumococcal Acute Otitis Media indication
Legionella Pneumophila Pneumonia indication
Pyrexia of unknown origin off-label use 7520000
Traveler's diarrhea off-label use 11840006
Enteric campylobacteriosis off-label use 18081009
Pertussis off-label use 27836007
Gonorrhea of rectum off-label use 42746002
Gonorrhea of pharynx off-label use 74372003
Coronavirus infection off-label use 186747009
Boutonneuse fever off-label use 186774005 DOID:14095
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Inflammatory Disease of Female Pelvic Organs off-label use
Sexual Transmitted Disease Exposure from Sexual Assault off-label use
Prevention of Bacterial Endocarditis off-label use
Jaundice contraindication 18165001
Torsades de pointes contraindication 31722008
Chronic heart failure contraindication 48447003
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Hearing disorder contraindication 128540005
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Pseudomembranous enterocolitis contraindication 397683000
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.45 acidic
pKa2 8.87 Basic
pKa3 8.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 3.39 WOMBAT-PK
Multidrug resistance protein 1 Transporter IC50 3.70 WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter IC50 4.16 WOMBAT-PK
Motilin receptor GPCR AGONIST EC50 5.50 IUPHAR
Taste receptor type 2 member 4 GPCR AGONIST EC50 4.13 IUPHAR

External reference:

IDSource
4020019 VUID
N0000148074 NUI
D02134 KEGG_DRUG
121470-24-4 SECONDARY_CAS_RN
117772-70-0 SECONDARY_CAS_RN
1298839 RXNORM
C0052796 UMLSCUI
CHEBI:231550 CHEBI
ZIT PDB_CHEM_ID
CHEMBL529 ChEMBL_ID
CHEMBL1200502 ChEMBL_ID
D017963 MESH_DESCRIPTOR_UI
DB00207 DRUGBANK_ID
6510 IUPHAR_LIGAND_ID
447043 PUBCHEM_CID
4238 MMSL
72442 MMSL
d00091 MMSL
6197 INN_ID
4020019 VANDF
4020964 VANDF
JTE4MNN1MD UNII
003635 NDDF
387531004 SNOMEDCT_US
391805000 SNOMEDCT_US
734459003 SNOMEDCT_US
785687007 SNOMEDCT_US
96034006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zithromax HUMAN PRESCRIPTION DRUG LABEL 1 0069-0400 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS NDA 31 sections
ZITHROMAX HUMAN PRESCRIPTION DRUG LABEL 1 0069-3051 POWDER, FOR SUSPENSION 1 g ORAL NDA 30 sections
Zithromax HUMAN PRESCRIPTION DRUG LABEL 1 0069-3060 TABLET, FILM COATED 250 mg ORAL NDA 30 sections
Zithromax HUMAN PRESCRIPTION DRUG LABEL 1 0069-3070 TABLET, FILM COATED 500 mg ORAL NDA 30 sections
ZITHROMAX HUMAN PRESCRIPTION DRUG LABEL 1 0069-3080 TABLET, FILM COATED 600 mg ORAL NDA 30 sections
Zithromax HUMAN PRESCRIPTION DRUG LABEL 1 0069-3110 POWDER, FOR SUSPENSION 100 mg ORAL NDA 30 sections
Zithromax HUMAN PRESCRIPTION DRUG LABEL 1 0069-3120 POWDER, FOR SUSPENSION 200 mg ORAL NDA 30 sections
Zithromax HUMAN PRESCRIPTION DRUG LABEL 1 0069-3130 POWDER, FOR SUSPENSION 200 mg ORAL NDA 30 sections
Zithromax HUMAN PRESCRIPTION DRUG LABEL 1 0069-3140 POWDER, FOR SUSPENSION 200 mg ORAL NDA 30 sections
Zithromax HUMAN PRESCRIPTION DRUG LABEL 1 0069-3150 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS NDA 30 sections
Zithromax HUMAN PRESCRIPTION DRUG LABEL 1 0069-4061 TABLET, FILM COATED 250 mg ORAL NDA 30 sections
Azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2026 POWDER, FOR SUSPENSION 200 mg ORAL ANDA 28 sections
Azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2027 POWDER, FOR SUSPENSION 100 mg ORAL ANDA 28 sections
azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 0527-2370 TABLET, FILM COATED 250 mg ORAL ANDA 29 sections
azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 0527-2395 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 0781-8089 TABLET, FILM COATED 250 mg ORAL ANDA 28 sections
Azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 0781-8090 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 0781-8091 TABLET, FILM COATED 600 mg ORAL ANDA 27 sections
azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 0904-7350 TABLET, FILM COATED 250 mg ORAL ANDA 27 sections
azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 0904-7351 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 11788-128 POWDER, FOR SUSPENSION 100 mg ORAL ANDA 19 sections
Azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 11788-129 POWDER, FOR SUSPENSION 200 mg ORAL ANDA 19 sections
AZITHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-383 TABLET, FILM COATED 500 mg ORAL ANDA 13 sections
AzaSITE HUMAN PRESCRIPTION DRUG LABEL 1 17478-307 SOLUTION/ DROPS 10 mg OPHTHALMIC NDA 27 sections
AZITHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 21695-012 TABLET, FILM COATED 250 mg ORAL ANDA 13 sections
AZITHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 21695-013 TABLET, FILM COATED 500 mg ORAL ANDA 13 sections
Azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 21695-548 POWDER, FOR SUSPENSION 100 mg ORAL ANDA 27 sections
Azithromycin HUMAN PRESCRIPTION DRUG LABEL 1 21695-549 POWDER, FOR SUSPENSION 200 mg ORAL ANDA 27 sections
AZITHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 24658-706 POWDER, FOR SUSPENSION 200 mg ORAL ANDA 29 sections
AZITHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 24658-707 POWDER, FOR SUSPENSION 200 mg ORAL ANDA 29 sections