Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, produced by Streptomyces strains | 276 | 83905-01-5 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
0.50 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 39 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 6 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 44.50 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 34 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 33 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.88 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 69 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 1, 1991 | FDA | ||
March 10, 2000 | PMDA | PFIZER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 1471.34 | 9.98 | 2022 | 90515 | 273183 | 55926347 |
Infective pulmonary exacerbation of cystic fibrosis | 779.69 | 9.98 | 342 | 92195 | 7815 | 56191715 |
Off label use | 538.15 | 9.98 | 2064 | 90473 | 554116 | 55645414 |
Abortion incomplete | 537.58 | 9.98 | 200 | 92337 | 2927 | 56196603 |
Rheumatoid arthritis | 304.99 | 9.98 | 124 | 92413 | 382480 | 55817050 |
Macular degeneration | 271.70 | 9.98 | 235 | 92302 | 18673 | 56180857 |
Asthma | 271.23 | 9.98 | 583 | 91954 | 112187 | 56087343 |
Cystic fibrosis | 270.67 | 9.98 | 126 | 92411 | 3318 | 56196212 |
Contraindicated product administered | 246.45 | 9.98 | 15 | 92522 | 186271 | 56013259 |
Abortion spontaneous | 235.93 | 9.98 | 324 | 92213 | 43429 | 56156101 |
Joint swelling | 235.56 | 9.98 | 91 | 92446 | 289709 | 55909821 |
Electrocardiogram QT prolonged | 207.00 | 9.98 | 343 | 92194 | 54245 | 56145285 |
Synovitis | 201.80 | 9.98 | 17 | 92520 | 161288 | 56038242 |
Hand deformity | 201.29 | 9.98 | 4 | 92533 | 134488 | 56065042 |
Wheezing | 180.41 | 9.98 | 388 | 92149 | 74638 | 56124892 |
Systemic lupus erythematosus | 180.38 | 9.98 | 38 | 92499 | 180040 | 56019490 |
Arthropathy | 174.43 | 9.98 | 56 | 92481 | 200219 | 55999311 |
Completed suicide | 173.33 | 9.98 | 12 | 92525 | 133821 | 56065709 |
Premature delivery | 173.13 | 9.98 | 218 | 92319 | 26842 | 56172688 |
Glossodynia | 165.98 | 9.98 | 26 | 92511 | 152432 | 56047098 |
Cholecystitis chronic | 164.56 | 9.98 | 133 | 92404 | 9615 | 56189915 |
Cough | 162.82 | 9.98 | 850 | 91687 | 259111 | 55940419 |
Therapeutic product effect decreased | 157.40 | 9.98 | 42 | 92495 | 169410 | 56030120 |
Exposure during pregnancy | 156.88 | 9.98 | 537 | 92000 | 135805 | 56063725 |
Haemorrhage | 151.16 | 9.98 | 305 | 92232 | 56092 | 56143438 |
Arthralgia | 147.46 | 9.98 | 385 | 92152 | 501284 | 55698246 |
Bronchiectasis | 142.21 | 9.98 | 131 | 92406 | 11303 | 56188227 |
Alopecia | 140.94 | 9.98 | 165 | 92372 | 293293 | 55906237 |
No adverse event | 138.45 | 9.98 | 229 | 92308 | 36145 | 56163385 |
Pneumonia | 132.87 | 9.98 | 1131 | 91406 | 405967 | 55793563 |
Product use in unapproved indication | 127.13 | 9.98 | 513 | 92024 | 140309 | 56059221 |
Product packaging quantity issue | 126.10 | 9.98 | 54 | 92483 | 1160 | 56198370 |
Wound | 124.06 | 9.98 | 37 | 92500 | 138767 | 56060763 |
Productive cough | 120.73 | 9.98 | 278 | 92259 | 55954 | 56143576 |
COVID-19 | 120.24 | 9.98 | 332 | 92205 | 74726 | 56124804 |
Infusion related reaction | 119.16 | 9.98 | 101 | 92436 | 208830 | 55990700 |
Pericarditis | 115.35 | 9.98 | 20 | 92517 | 108903 | 56090627 |
Injury | 113.51 | 9.98 | 282 | 92255 | 59569 | 56139961 |
Emotional distress | 112.76 | 9.98 | 187 | 92350 | 29576 | 56169954 |
Sputum discoloured | 110.86 | 9.98 | 127 | 92410 | 14165 | 56185365 |
Swelling | 106.51 | 9.98 | 143 | 92394 | 239628 | 55959902 |
Sleep disorder due to a general medical condition | 101.29 | 9.98 | 98 | 92439 | 8992 | 56190538 |
Hepatic enzyme increased | 98.74 | 9.98 | 82 | 92455 | 171302 | 56028228 |
Upper respiratory tract infection | 98.43 | 9.98 | 299 | 92238 | 70989 | 56128541 |
Helicobacter infection | 96.52 | 9.98 | 6 | 92531 | 73262 | 56126268 |
Treatment failure | 95.15 | 9.98 | 84 | 92453 | 170308 | 56029222 |
Drug intolerance | 88.96 | 9.98 | 189 | 92348 | 264629 | 55934901 |
Bronchitis | 88.77 | 9.98 | 393 | 92144 | 111918 | 56087612 |
Haemoptysis | 86.38 | 9.98 | 156 | 92381 | 26404 | 56173126 |
Drug ineffective for unapproved indication | 84.95 | 9.98 | 152 | 92385 | 25541 | 56173989 |
Pulmonary function test decreased | 82.74 | 9.98 | 59 | 92478 | 3532 | 56195998 |
Mycobacterium avium complex infection | 82.38 | 9.98 | 54 | 92483 | 2815 | 56196715 |
Nasal polyps | 80.70 | 9.98 | 56 | 92481 | 3209 | 56196321 |
Long QT syndrome | 78.96 | 9.98 | 54 | 92483 | 3022 | 56196508 |
Normal labour | 76.91 | 9.98 | 22 | 92515 | 129 | 56199401 |
Discomfort | 76.61 | 9.98 | 72 | 92465 | 141689 | 56057841 |
Pulmonary embolism | 75.87 | 9.98 | 363 | 92174 | 106761 | 56092769 |
Biliary dyskinesia | 75.45 | 9.98 | 49 | 92488 | 2514 | 56197016 |
Abdominal discomfort | 73.68 | 9.98 | 223 | 92314 | 277051 | 55922479 |
Muscle injury | 73.26 | 9.98 | 3 | 92534 | 52497 | 56147033 |
Anosmia | 71.86 | 9.98 | 59 | 92478 | 4360 | 56195170 |
Rhinitis allergic | 70.32 | 9.98 | 78 | 92459 | 8396 | 56191134 |
Fatigue | 68.40 | 9.98 | 901 | 91636 | 787651 | 55411879 |
Folliculitis | 68.14 | 9.98 | 6 | 92531 | 54973 | 56144557 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 68.13 | 9.98 | 30 | 92507 | 691 | 56198839 |
Hypoxia | 67.87 | 9.98 | 219 | 92318 | 53678 | 56145852 |
Impaired healing | 67.60 | 9.98 | 29 | 92508 | 86812 | 56112718 |
Mobility decreased | 66.68 | 9.98 | 40 | 92497 | 98951 | 56100579 |
Infective exacerbation of bronchiectasis | 66.59 | 9.98 | 24 | 92513 | 319 | 56199211 |
Peripheral swelling | 66.57 | 9.98 | 183 | 92354 | 234543 | 55964987 |
Drug interaction | 66.21 | 9.98 | 579 | 91958 | 209176 | 55990354 |
Delivery | 65.16 | 9.98 | 31 | 92506 | 858 | 56198672 |
Deafness | 64.31 | 9.98 | 105 | 92432 | 16389 | 56183141 |
Intentional overdose | 62.98 | 9.98 | 17 | 92520 | 68100 | 56131430 |
Respiratory failure | 62.92 | 9.98 | 316 | 92221 | 94746 | 56104784 |
Cystic fibrosis respiratory infection suppression | 59.40 | 9.98 | 21 | 92516 | 263 | 56199267 |
Chronic obstructive pulmonary disease | 58.96 | 9.98 | 218 | 92319 | 57197 | 56142333 |
Eosinophilic pneumonia | 58.70 | 9.98 | 38 | 92499 | 1939 | 56197591 |
Pathogen resistance | 58.21 | 9.98 | 60 | 92477 | 5940 | 56193590 |
Torsade de pointes | 56.57 | 9.98 | 85 | 92452 | 12355 | 56187175 |
Product dose omission issue | 55.93 | 9.98 | 548 | 91989 | 204205 | 55995325 |
Sleep disorder due to general medical condition, insomnia type | 55.75 | 9.98 | 4 | 92533 | 43334 | 56156196 |
Fall | 55.06 | 9.98 | 353 | 92184 | 357157 | 55842373 |
Rales | 55.00 | 9.98 | 78 | 92459 | 10762 | 56188768 |
Product quality issue | 54.42 | 9.98 | 144 | 92393 | 31592 | 56167938 |
Total lung capacity increased | 54.14 | 9.98 | 28 | 92509 | 931 | 56198599 |
Obstructive airways disorder | 53.03 | 9.98 | 99 | 92438 | 17183 | 56182347 |
Factor V inhibition | 52.54 | 9.98 | 17 | 92520 | 159 | 56199371 |
Toxicity to various agents | 52.47 | 9.98 | 191 | 92346 | 224373 | 55975157 |
Dyspnoea | 52.22 | 9.98 | 1308 | 91229 | 591269 | 55608261 |
Chronic kidney disease | 52.15 | 9.98 | 170 | 92367 | 41886 | 56157644 |
Cholelithiasis | 52.10 | 9.98 | 163 | 92374 | 39301 | 56160229 |
Drug abuse | 51.95 | 9.98 | 23 | 92514 | 67587 | 56131943 |
Stevens-Johnson syndrome | 51.91 | 9.98 | 115 | 92422 | 22548 | 56176982 |
Musculoskeletal stiffness | 51.78 | 9.98 | 112 | 92425 | 155895 | 56043635 |
Gallbladder disorder | 51.58 | 9.98 | 98 | 92439 | 17236 | 56182294 |
Acute generalised exanthematous pustulosis | 51.54 | 9.98 | 72 | 92465 | 9797 | 56189733 |
Death | 49.11 | 9.98 | 344 | 92193 | 341082 | 55858448 |
Forced expiratory volume decreased | 47.76 | 9.98 | 48 | 92489 | 4612 | 56194918 |
Full blood count abnormal | 47.35 | 9.98 | 122 | 92415 | 26340 | 56173190 |
Respiratory tract infection | 46.71 | 9.98 | 148 | 92389 | 35923 | 56163607 |
Eosinophilia | 46.12 | 9.98 | 102 | 92435 | 19975 | 56179555 |
Blister | 45.25 | 9.98 | 68 | 92469 | 108819 | 56090711 |
Malignant neoplasm progression | 43.86 | 9.98 | 34 | 92503 | 73553 | 56125977 |
Chest discomfort | 43.50 | 9.98 | 295 | 92242 | 98562 | 56100968 |
Product use issue | 41.00 | 9.98 | 162 | 92375 | 185879 | 56013651 |
Drug-induced liver injury | 40.67 | 9.98 | 137 | 92400 | 34325 | 56165205 |
Tinnitus | 40.50 | 9.98 | 125 | 92412 | 29917 | 56169613 |
Irritable bowel syndrome | 40.33 | 9.98 | 32 | 92505 | 68426 | 56131104 |
Drug reaction with eosinophilia and systemic symptoms | 39.84 | 9.98 | 125 | 92412 | 30179 | 56169351 |
Symmetrical drug-related intertriginous and flexural exanthema | 39.66 | 9.98 | 17 | 92520 | 366 | 56199164 |
Lung opacity | 39.63 | 9.98 | 32 | 92505 | 2309 | 56197221 |
Maternal exposure during pregnancy | 39.58 | 9.98 | 481 | 92056 | 189072 | 56010458 |
Low birth weight baby | 39.35 | 9.98 | 50 | 92487 | 6208 | 56193322 |
Prolonged expiration | 39.28 | 9.98 | 22 | 92515 | 860 | 56198670 |
Heart sounds | 38.72 | 9.98 | 21 | 92516 | 770 | 56198760 |
Eosinophil count increased | 38.45 | 9.98 | 62 | 92475 | 9575 | 56189955 |
Stomatitis | 38.23 | 9.98 | 89 | 92448 | 120721 | 56078809 |
Alveolitis | 37.94 | 9.98 | 33 | 92504 | 2640 | 56196890 |
Auscultation | 37.89 | 9.98 | 7 | 92530 | 0 | 56199530 |
Pseudomonas infection | 37.76 | 9.98 | 63 | 92474 | 10008 | 56189522 |
Breath sounds abnormal | 37.38 | 9.98 | 59 | 92478 | 8948 | 56190582 |
Confusional state | 37.08 | 9.98 | 196 | 92341 | 207959 | 55991571 |
Dysbiosis | 36.79 | 9.98 | 20 | 92517 | 737 | 56198793 |
Kounis syndrome | 36.22 | 9.98 | 24 | 92513 | 1274 | 56198256 |
Lip oedema | 35.96 | 9.98 | 36 | 92501 | 3442 | 56196088 |
Suicide attempt | 35.39 | 9.98 | 26 | 92511 | 57810 | 56141720 |
Respiration abnormal | 35.36 | 9.98 | 45 | 92492 | 5596 | 56193934 |
Bronchopulmonary aspergillosis allergic | 33.87 | 9.98 | 24 | 92513 | 1422 | 56198108 |
Chronic sinusitis | 33.56 | 9.98 | 54 | 92483 | 8324 | 56191206 |
Rheumatic fever | 33.51 | 9.98 | 4 | 92533 | 28823 | 56170707 |
Drug resistance | 33.00 | 9.98 | 91 | 92446 | 20451 | 56179079 |
Sinusitis | 32.80 | 9.98 | 481 | 92056 | 197100 | 56002430 |
Deep vein thrombosis | 32.25 | 9.98 | 227 | 92310 | 76750 | 56122780 |
Acute respiratory distress syndrome | 32.17 | 9.98 | 94 | 92443 | 21832 | 56177698 |
Psoriatic arthropathy | 31.94 | 9.98 | 45 | 92492 | 73963 | 56125567 |
Sputum increased | 31.72 | 9.98 | 27 | 92510 | 2097 | 56197433 |
Ventricular fibrillation | 31.45 | 9.98 | 61 | 92476 | 10891 | 56188639 |
Knee arthroplasty | 31.06 | 9.98 | 17 | 92520 | 44242 | 56155288 |
Total lung capacity decreased | 30.98 | 9.98 | 23 | 92514 | 1466 | 56198064 |
Cystic fibrosis pancreatic | 30.61 | 9.98 | 9 | 92528 | 59 | 56199471 |
Myasthenia gravis crisis | 30.42 | 9.98 | 15 | 92522 | 450 | 56199080 |
Congenital absence of cranial vault | 30.22 | 9.98 | 7 | 92530 | 14 | 56199516 |
Bronchopulmonary aspergillosis | 30.06 | 9.98 | 51 | 92486 | 8213 | 56191317 |
Pelvic inflammatory disease | 30.01 | 9.98 | 23 | 92514 | 1538 | 56197992 |
Toxic epidermal necrolysis | 29.98 | 9.98 | 92 | 92445 | 21950 | 56177580 |
Oropharyngeal pain | 29.96 | 9.98 | 238 | 92299 | 83550 | 56115980 |
Middle lobe syndrome | 29.90 | 9.98 | 8 | 92529 | 35 | 56199495 |
Hip arthroplasty | 29.89 | 9.98 | 13 | 92524 | 38610 | 56160920 |
Flank pain | 29.82 | 9.98 | 70 | 92467 | 14255 | 56185275 |
Distal intestinal obstruction syndrome | 29.74 | 9.98 | 14 | 92523 | 378 | 56199152 |
COVID-19 pneumonia | 29.67 | 9.98 | 60 | 92477 | 11042 | 56188488 |
Overdose | 29.59 | 9.98 | 83 | 92454 | 105747 | 56093783 |
Foetal exposure during pregnancy | 29.50 | 9.98 | 122 | 92415 | 33701 | 56165829 |
Device expulsion | 29.29 | 9.98 | 7 | 92530 | 30442 | 56169088 |
Mixed liver injury | 28.83 | 9.98 | 34 | 92503 | 3910 | 56195620 |
Pneumothorax spontaneous | 28.63 | 9.98 | 17 | 92520 | 743 | 56198787 |
Pneumothorax | 28.11 | 9.98 | 70 | 92467 | 14797 | 56184733 |
Somnolence | 27.92 | 9.98 | 156 | 92381 | 163257 | 56036273 |
Bronchial wall thickening | 27.82 | 9.98 | 19 | 92518 | 1061 | 56198469 |
C-reactive protein abnormal | 27.53 | 9.98 | 13 | 92524 | 36796 | 56162734 |
Anxiety | 27.39 | 9.98 | 458 | 92079 | 192714 | 56006816 |
Hallucinations, mixed | 27.27 | 9.98 | 35 | 92502 | 4389 | 56195141 |
Gallbladder injury | 26.87 | 9.98 | 20 | 92517 | 1280 | 56198250 |
Ototoxicity | 26.50 | 9.98 | 19 | 92518 | 1147 | 56198383 |
Pregnancy | 26.37 | 9.98 | 116 | 92421 | 32917 | 56166613 |
Joint range of motion decreased | 26.10 | 9.98 | 5 | 92532 | 25360 | 56174170 |
Hypersensitivity | 25.87 | 9.98 | 283 | 92254 | 256125 | 55943405 |
Mycobacterial infection | 25.86 | 9.98 | 22 | 92515 | 1708 | 56197822 |
Pain | 25.80 | 9.98 | 863 | 91674 | 662321 | 55537209 |
Amniotic cavity infection | 25.76 | 9.98 | 19 | 92518 | 1199 | 56198331 |
Urticaria | 25.51 | 9.98 | 356 | 92181 | 144320 | 56055210 |
Gastroenteritis staphylococcal | 25.20 | 9.98 | 8 | 92529 | 70 | 56199460 |
Rheumatoid factor | 25.20 | 9.98 | 8 | 92529 | 70 | 56199460 |
Cystic fibrosis lung | 25.15 | 9.98 | 9 | 92528 | 117 | 56199413 |
Mycobacterium abscessus infection | 25.15 | 9.98 | 15 | 92522 | 661 | 56198869 |
Mechanical urticaria | 24.98 | 9.98 | 13 | 92524 | 438 | 56199092 |
Pulmonary function test abnormal | 24.94 | 9.98 | 20 | 92517 | 1429 | 56198101 |
Agranulocytosis | 24.92 | 9.98 | 88 | 92449 | 22571 | 56176959 |
Factor V deficiency | 24.80 | 9.98 | 8 | 92529 | 74 | 56199456 |
Abdominal pain | 24.69 | 9.98 | 578 | 91959 | 258227 | 55941303 |
Anhedonia | 24.64 | 9.98 | 52 | 92485 | 9862 | 56189668 |
Febrile neutropenia | 24.47 | 9.98 | 90 | 92447 | 105455 | 56094075 |
Sarcoidosis | 24.29 | 9.98 | 37 | 92500 | 5443 | 56194087 |
Blood cholesterol increased | 24.15 | 9.98 | 52 | 92485 | 72527 | 56127003 |
Premature baby | 24.13 | 9.98 | 78 | 92459 | 19127 | 56180403 |
Gallbladder cholesterolosis | 23.96 | 9.98 | 15 | 92522 | 722 | 56198808 |
Ageusia | 23.94 | 9.98 | 59 | 92478 | 12392 | 56187138 |
Transaminases increased | 23.71 | 9.98 | 102 | 92435 | 28668 | 56170862 |
Obliterative bronchiolitis | 23.41 | 9.98 | 22 | 92515 | 1946 | 56197584 |
Stenotrophomonas infection | 23.31 | 9.98 | 21 | 92516 | 1760 | 56197770 |
Rhinorrhoea | 23.19 | 9.98 | 167 | 92370 | 56870 | 56142660 |
Coma | 23.12 | 9.98 | 39 | 92498 | 59616 | 56139914 |
Lung transplant rejection | 23.04 | 9.98 | 15 | 92522 | 773 | 56198757 |
Epidermolysis | 23.01 | 9.98 | 10 | 92527 | 223 | 56199307 |
Staphylococcus test positive | 22.93 | 9.98 | 29 | 92508 | 3584 | 56195946 |
Type 2 diabetes mellitus | 22.81 | 9.98 | 26 | 92511 | 46836 | 56152694 |
Neutrophil count decreased | 22.81 | 9.98 | 29 | 92508 | 49793 | 56149737 |
Breast cancer | 22.80 | 9.98 | 28 | 92509 | 48805 | 56150725 |
Injection site pain | 22.71 | 9.98 | 107 | 92430 | 117011 | 56082519 |
Platelet count decreased | 22.56 | 9.98 | 94 | 92443 | 106289 | 56093241 |
Sedation | 22.20 | 9.98 | 15 | 92522 | 34839 | 56164691 |
Uterine perforation | 22.16 | 9.98 | 39 | 92498 | 6466 | 56193064 |
Endometritis | 22.15 | 9.98 | 16 | 92521 | 977 | 56198553 |
Respiratory tract congestion | 22.07 | 9.98 | 66 | 92471 | 15525 | 56184005 |
Granulomatosis with polyangiitis | 22.07 | 9.98 | 22 | 92515 | 2093 | 56197437 |
Influenza | 21.75 | 9.98 | 246 | 92291 | 95015 | 56104515 |
Delusional disorder, persecutory type | 21.75 | 9.98 | 9 | 92528 | 177 | 56199353 |
Orthostatic hypotension | 21.54 | 9.98 | 14 | 92523 | 33185 | 56166345 |
Gastrointestinal disorder | 21.25 | 9.98 | 104 | 92433 | 112598 | 56086932 |
Disseminated mycobacterium avium complex infection | 21.20 | 9.98 | 8 | 92529 | 122 | 56199408 |
Pneumonia pseudomonal | 21.14 | 9.98 | 22 | 92515 | 2202 | 56197328 |
Hospitalisation | 21.06 | 9.98 | 202 | 92335 | 74798 | 56124732 |
Oral candidiasis | 20.74 | 9.98 | 73 | 92464 | 18690 | 56180840 |
Injection site erythema | 20.73 | 9.98 | 62 | 92475 | 77386 | 56122144 |
Pulmonary infarction | 20.63 | 9.98 | 23 | 92514 | 2489 | 56197041 |
Atypical mycobacterial infection | 20.55 | 9.98 | 15 | 92522 | 931 | 56198599 |
Appetite disorder | 20.51 | 9.98 | 38 | 92499 | 6555 | 56192975 |
Neutropenia | 20.48 | 9.98 | 164 | 92373 | 158003 | 56041527 |
Hypertension | 20.32 | 9.98 | 281 | 92256 | 243997 | 55955533 |
Viral infection | 20.28 | 9.98 | 105 | 92432 | 31841 | 56167689 |
Bronchomalacia | 20.21 | 9.98 | 9 | 92528 | 213 | 56199317 |
Pneumomediastinum | 20.00 | 9.98 | 17 | 92520 | 1318 | 56198212 |
Cystic fibrosis related diabetes | 19.95 | 9.98 | 6 | 92531 | 43 | 56199487 |
Osteoarthritis | 19.59 | 9.98 | 67 | 92470 | 80229 | 56119301 |
Gait disturbance | 19.50 | 9.98 | 173 | 92364 | 163148 | 56036382 |
Blood pressure fluctuation | 18.99 | 9.98 | 23 | 92514 | 40337 | 56159193 |
Actinic keratosis | 18.83 | 9.98 | 21 | 92516 | 2274 | 56197256 |
Pyrexia | 18.64 | 9.98 | 854 | 91683 | 417919 | 55781611 |
Pancreatic failure | 18.60 | 9.98 | 14 | 92523 | 911 | 56198619 |
White blood cell count decreased | 18.53 | 9.98 | 126 | 92411 | 125864 | 56073666 |
Hypokalaemia | 18.47 | 9.98 | 86 | 92451 | 94351 | 56105179 |
Drug effective for unapproved indication | 18.42 | 9.98 | 22 | 92515 | 2564 | 56196966 |
Impaired quality of life | 18.29 | 9.98 | 42 | 92495 | 8432 | 56191098 |
Hepatocellular injury | 18.14 | 9.98 | 89 | 92448 | 26425 | 56173105 |
Gastrointestinal haemorrhage | 18.11 | 9.98 | 64 | 92473 | 75887 | 56123643 |
Biliary colic | 18.03 | 9.98 | 25 | 92512 | 3377 | 56196153 |
Fibromyalgia | 17.98 | 9.98 | 45 | 92492 | 59558 | 56139972 |
Cardiac arrest | 17.97 | 9.98 | 219 | 92318 | 86095 | 56113435 |
Joint stiffness | 17.96 | 9.98 | 19 | 92518 | 35406 | 56164124 |
Pain in extremity | 17.91 | 9.98 | 363 | 92174 | 297068 | 55902462 |
Procedural pain | 17.73 | 9.98 | 63 | 92474 | 16208 | 56183322 |
Contusion | 17.64 | 9.98 | 131 | 92406 | 128299 | 56071231 |
Vaginal stricture | 17.62 | 9.98 | 4 | 92533 | 7 | 56199523 |
Post polio syndrome | 17.62 | 9.98 | 4 | 92533 | 7 | 56199523 |
Mucosal inflammation | 17.52 | 9.98 | 27 | 92510 | 42783 | 56156747 |
Chest pain | 17.51 | 9.98 | 422 | 92115 | 189375 | 56010155 |
Upper-airway cough syndrome | 17.38 | 9.98 | 44 | 92493 | 9394 | 56190136 |
Therapeutic response decreased | 17.38 | 9.98 | 38 | 92499 | 52720 | 56146810 |
Chlamydial infection | 17.38 | 9.98 | 9 | 92528 | 300 | 56199230 |
Increased bronchial secretion | 17.29 | 9.98 | 17 | 92520 | 1590 | 56197940 |
Aspergillus infection | 17.23 | 9.98 | 38 | 92499 | 7427 | 56192103 |
Meningism | 17.07 | 9.98 | 10 | 92527 | 426 | 56199104 |
Staphylococcal infection | 16.98 | 9.98 | 113 | 92424 | 37505 | 56162025 |
Bronchial secretion retention | 16.90 | 9.98 | 18 | 92519 | 1850 | 56197680 |
Hypotension | 16.84 | 9.98 | 300 | 92237 | 250208 | 55949322 |
Adverse drug reaction | 16.82 | 9.98 | 53 | 92484 | 65079 | 56134451 |
Immune reconstitution inflammatory syndrome | 16.78 | 9.98 | 32 | 92505 | 5642 | 56193888 |
Weight increased | 16.77 | 9.98 | 271 | 92266 | 229432 | 55970098 |
Laryngeal mass | 16.72 | 9.98 | 5 | 92532 | 35 | 56199495 |
Palmar-plantar erythrodysaesthesia syndrome | 16.44 | 9.98 | 7 | 92530 | 21058 | 56178472 |
Acute respiratory failure | 16.42 | 9.98 | 97 | 92440 | 30897 | 56168633 |
Immunodeficiency common variable | 16.40 | 9.98 | 7 | 92530 | 149 | 56199381 |
Mucocutaneous candidiasis | 16.38 | 9.98 | 4 | 92533 | 11 | 56199519 |
Pigment nephropathy | 16.37 | 9.98 | 5 | 92532 | 38 | 56199492 |
Bronchogram abnormal | 16.24 | 9.98 | 3 | 92534 | 0 | 56199530 |
Portal hypertensive enteropathy | 16.24 | 9.98 | 3 | 92534 | 0 | 56199530 |
General physical health deterioration | 16.20 | 9.98 | 190 | 92347 | 169820 | 56029710 |
Tachypnoea | 16.18 | 9.98 | 59 | 92478 | 15371 | 56184159 |
Cholestasis | 16.09 | 9.98 | 87 | 92450 | 26826 | 56172704 |
Iris transillumination defect | 16.05 | 9.98 | 6 | 92531 | 89 | 56199441 |
Injection site bruising | 16.05 | 9.98 | 24 | 92513 | 38497 | 56161033 |
Myasthenia gravis | 16.00 | 9.98 | 27 | 92510 | 4329 | 56195201 |
Chest X-ray abnormal | 15.99 | 9.98 | 26 | 92511 | 4044 | 56195486 |
Gastrooesophageal reflux disease | 15.95 | 9.98 | 208 | 92329 | 83049 | 56116481 |
Crystal arthropathy | 15.89 | 9.98 | 8 | 92529 | 251 | 56199279 |
Cardiac murmur | 15.89 | 9.98 | 48 | 92489 | 11353 | 56188177 |
Emphysema | 15.83 | 9.98 | 44 | 92493 | 9932 | 56189598 |
Adverse event | 15.79 | 9.98 | 43 | 92494 | 55333 | 56144197 |
Cognitive disorder | 15.69 | 9.98 | 36 | 92501 | 49097 | 56150433 |
Hemianopia heteronymous | 15.62 | 9.98 | 5 | 92532 | 45 | 56199485 |
Injection site swelling | 15.53 | 9.98 | 30 | 92507 | 43548 | 56155982 |
Ill-defined disorder | 15.52 | 9.98 | 59 | 92478 | 68484 | 56131046 |
Peak expiratory flow rate abnormal | 15.46 | 9.98 | 6 | 92531 | 99 | 56199431 |
Multiple allergies | 15.40 | 9.98 | 45 | 92492 | 10451 | 56189079 |
Leukaemoid reaction | 15.33 | 9.98 | 7 | 92530 | 176 | 56199354 |
Hypoxic-ischaemic encephalopathy | 15.22 | 9.98 | 25 | 92512 | 3920 | 56195610 |
Eosinophilic pneumonia chronic | 15.12 | 9.98 | 7 | 92530 | 182 | 56199348 |
Thermal burn | 15.08 | 9.98 | 30 | 92507 | 5455 | 56194075 |
Erythema multiforme | 15.02 | 9.98 | 42 | 92495 | 9512 | 56190018 |
Lung disorder | 14.93 | 9.98 | 142 | 92395 | 52455 | 56147075 |
Pharyngeal enanthema | 14.81 | 9.98 | 5 | 92532 | 54 | 56199476 |
Neural tube defect | 14.74 | 9.98 | 7 | 92530 | 193 | 56199337 |
Gait inability | 14.72 | 9.98 | 29 | 92508 | 41789 | 56157741 |
Lemierre syndrome | 14.69 | 9.98 | 6 | 92531 | 114 | 56199416 |
COVID-19 treatment | 14.64 | 9.98 | 6 | 92531 | 115 | 56199415 |
Arthritis | 14.61 | 9.98 | 100 | 92437 | 99752 | 56099778 |
Hypersensitivity pneumonitis | 14.58 | 9.98 | 19 | 92518 | 2418 | 56197112 |
Humidity intolerance | 14.51 | 9.98 | 8 | 92529 | 303 | 56199227 |
Nasal congestion | 14.45 | 9.98 | 149 | 92388 | 56221 | 56143309 |
Respiratory tract inflammation | 14.44 | 9.98 | 10 | 92527 | 571 | 56198959 |
Depressive symptom | 14.43 | 9.98 | 23 | 92514 | 3518 | 56196012 |
Rebound acid hypersecretion | 14.40 | 9.98 | 8 | 92529 | 308 | 56199222 |
Oesophagogastroduodenoscopy | 14.36 | 9.98 | 6 | 92531 | 121 | 56199409 |
Pneumonia bacterial | 14.34 | 9.98 | 37 | 92500 | 7991 | 56191539 |
Hypercapnia | 14.17 | 9.98 | 28 | 92509 | 5068 | 56194462 |
Acute kidney injury | 14.16 | 9.98 | 506 | 92031 | 240257 | 55959273 |
Hyponatraemia | 14.11 | 9.98 | 104 | 92433 | 102035 | 56097495 |
Paraesthesia oral | 14.11 | 9.98 | 54 | 92483 | 14395 | 56185135 |
Disease progression | 14.10 | 9.98 | 108 | 92429 | 105065 | 56094465 |
Hypofibrinogenaemia | 14.08 | 9.98 | 13 | 92524 | 1124 | 56198406 |
Hepatitis cholestatic | 14.07 | 9.98 | 32 | 92505 | 6382 | 56193148 |
Catastrophic reaction | 14.05 | 9.98 | 4 | 92533 | 23 | 56199507 |
Ear discomfort | 14.04 | 9.98 | 34 | 92503 | 7061 | 56192469 |
Ventricular tachycardia | 13.98 | 9.98 | 60 | 92477 | 16841 | 56182689 |
Mycoplasma infection | 13.92 | 9.98 | 9 | 92528 | 458 | 56199072 |
Lymph node abscess | 13.91 | 9.98 | 4 | 92533 | 24 | 56199506 |
Infusion site streaking | 13.80 | 9.98 | 9 | 92528 | 465 | 56199065 |
Foetal death | 13.75 | 9.98 | 38 | 92499 | 8549 | 56190981 |
Urinary tract infection | 13.74 | 9.98 | 296 | 92241 | 240217 | 55959313 |
Meningoencephalitis bacterial | 13.70 | 9.98 | 5 | 92532 | 69 | 56199461 |
Prescribed overdose | 13.67 | 9.98 | 10 | 92527 | 22286 | 56177244 |
Autoimmune hepatitis | 13.63 | 9.98 | 36 | 92501 | 7885 | 56191645 |
Respiratory distress | 13.62 | 9.98 | 94 | 92443 | 31573 | 56167957 |
Sleep disorder | 13.60 | 9.98 | 61 | 92476 | 67602 | 56131928 |
Seasonal allergy | 13.59 | 9.98 | 60 | 92477 | 17048 | 56182482 |
Muscle spasticity | 13.52 | 9.98 | 8 | 92529 | 19952 | 56179578 |
Disease risk factor | 13.51 | 9.98 | 5 | 92532 | 72 | 56199458 |
Brain hypoxia | 13.49 | 9.98 | 9 | 92528 | 483 | 56199047 |
Monoclonal gammopathy | 13.49 | 9.98 | 10 | 92527 | 636 | 56198894 |
Hypoacusis | 13.44 | 9.98 | 71 | 92466 | 21697 | 56177833 |
Forced vital capacity decreased | 13.44 | 9.98 | 12 | 92525 | 994 | 56198536 |
Local reaction | 13.42 | 9.98 | 10 | 92527 | 641 | 56198889 |
Urethral stenosis | 13.42 | 9.98 | 7 | 92530 | 237 | 56199293 |
Cholecystitis | 13.32 | 9.98 | 53 | 92484 | 14382 | 56185148 |
Sputum retention | 13.30 | 9.98 | 9 | 92528 | 495 | 56199035 |
Injection site reaction | 13.28 | 9.98 | 44 | 92493 | 53203 | 56146327 |
Babesiosis | 13.26 | 9.98 | 7 | 92530 | 243 | 56199287 |
Pneumonitis | 13.16 | 9.98 | 93 | 92444 | 31471 | 56168059 |
Sinus congestion | 13.15 | 9.98 | 56 | 92481 | 15668 | 56183862 |
Liver injury | 13.09 | 9.98 | 31 | 92506 | 41817 | 56157713 |
Sinus disorder | 13.06 | 9.98 | 68 | 92469 | 20666 | 56178864 |
Prescribed underdose | 12.96 | 9.98 | 9 | 92528 | 20608 | 56178922 |
Kawasaki's disease | 12.95 | 9.98 | 3 | 92534 | 6 | 56199524 |
Asthmatic crisis | 12.93 | 9.98 | 15 | 92522 | 1695 | 56197835 |
Gallbladder hypofunction | 12.92 | 9.98 | 9 | 92528 | 519 | 56199011 |
Corneal perforation | 12.89 | 9.98 | 9 | 92528 | 521 | 56199009 |
Procedural anxiety | 12.72 | 9.98 | 10 | 92527 | 694 | 56198836 |
Veillonella infection | 12.70 | 9.98 | 4 | 92533 | 34 | 56199496 |
Tympanic membrane hyperaemia | 12.64 | 9.98 | 3 | 92534 | 7 | 56199523 |
Balance disorder | 12.54 | 9.98 | 74 | 92463 | 76446 | 56123084 |
Pneumonia necrotising | 12.52 | 9.98 | 8 | 92529 | 399 | 56199131 |
Psoriasis | 12.51 | 9.98 | 95 | 92442 | 92597 | 56106933 |
Cerebral venous sinus thrombosis | 12.46 | 9.98 | 15 | 92522 | 1763 | 56197767 |
Dermatosis | 12.42 | 9.98 | 7 | 92530 | 277 | 56199253 |
Eye irritation | 12.40 | 9.98 | 63 | 92474 | 18965 | 56180565 |
Nosocomial infection | 12.37 | 9.98 | 14 | 92523 | 1540 | 56197990 |
Bacterial disease carrier | 12.35 | 9.98 | 11 | 92526 | 908 | 56198622 |
Injection site warmth | 12.35 | 9.98 | 4 | 92533 | 14239 | 56185291 |
Breast cancer metastatic | 12.30 | 9.98 | 5 | 92532 | 15464 | 56184066 |
Nocardiosis | 12.26 | 9.98 | 15 | 92522 | 1793 | 56197737 |
Diabetic ketoacidosis | 12.18 | 9.98 | 8 | 92529 | 18863 | 56180667 |
Neisseria infection | 12.14 | 9.98 | 5 | 92532 | 97 | 56199433 |
Deafness neurosensory | 12.09 | 9.98 | 25 | 92512 | 4673 | 56194857 |
Altered state of consciousness | 12.07 | 9.98 | 12 | 92525 | 23009 | 56176521 |
Sopor | 12.04 | 9.98 | 10 | 92527 | 20912 | 56178618 |
Developmental delay | 12.03 | 9.98 | 13 | 92524 | 1359 | 56198171 |
Ruptured ectopic pregnancy | 12.02 | 9.98 | 8 | 92529 | 428 | 56199102 |
Central nervous system fungal infection | 11.96 | 9.98 | 5 | 92532 | 101 | 56199429 |
Stomatococcal infection | 11.91 | 9.98 | 5 | 92532 | 102 | 56199428 |
Product colour issue | 11.91 | 9.98 | 9 | 92528 | 589 | 56198941 |
Muscular weakness | 11.87 | 9.98 | 112 | 92425 | 104340 | 56095190 |
Osteonecrosis of jaw | 11.86 | 9.98 | 23 | 92514 | 33335 | 56166195 |
Pneumonia aspiration | 11.83 | 9.98 | 22 | 92515 | 32389 | 56167141 |
Dysarthria | 11.82 | 9.98 | 30 | 92507 | 39520 | 56160010 |
HIV infection | 11.72 | 9.98 | 8 | 92529 | 446 | 56199084 |
Respiratory syncytial virus infection | 11.71 | 9.98 | 27 | 92510 | 5434 | 56194096 |
Pneumopericardium | 11.70 | 9.98 | 4 | 92533 | 45 | 56199485 |
Vascular parkinsonism | 11.69 | 9.98 | 5 | 92532 | 107 | 56199423 |
Interleukin level increased | 11.62 | 9.98 | 7 | 92530 | 314 | 56199216 |
Biopsy colon abnormal | 11.61 | 9.98 | 5 | 92532 | 109 | 56199421 |
Cranial nerve paralysis | 11.61 | 9.98 | 5 | 92532 | 109 | 56199421 |
Metastases to liver | 11.61 | 9.98 | 11 | 92526 | 21575 | 56177955 |
Sputum purulent | 11.59 | 9.98 | 11 | 92526 | 985 | 56198545 |
Increased upper airway secretion | 11.50 | 9.98 | 20 | 92517 | 3284 | 56196246 |
Paranasal sinus inflammation | 11.47 | 9.98 | 8 | 92529 | 462 | 56199068 |
Acute sinusitis | 11.46 | 9.98 | 21 | 92516 | 3592 | 56195938 |
Dysentery | 11.46 | 9.98 | 10 | 92527 | 803 | 56198727 |
Rhinovirus infection | 11.45 | 9.98 | 22 | 92515 | 3900 | 56195630 |
Constipation | 11.40 | 9.98 | 249 | 92288 | 201694 | 55997836 |
Acute disseminated encephalomyelitis | 11.37 | 9.98 | 6 | 92531 | 208 | 56199322 |
Anal inflammation | 11.37 | 9.98 | 6 | 92531 | 208 | 56199322 |
Eosinophilic pneumonia acute | 11.37 | 9.98 | 7 | 92530 | 327 | 56199203 |
Anal skin tags | 11.35 | 9.98 | 8 | 92529 | 470 | 56199060 |
Abscess bacterial | 11.35 | 9.98 | 6 | 92531 | 209 | 56199321 |
Dysphonia | 11.29 | 9.98 | 112 | 92425 | 41835 | 56157695 |
Depressed level of consciousness | 11.27 | 9.98 | 51 | 92486 | 56382 | 56143148 |
BK virus infection | 11.26 | 9.98 | 19 | 92518 | 3045 | 56196485 |
Mucosal dryness | 11.26 | 9.98 | 17 | 92520 | 2481 | 56197049 |
Epilepsy | 11.22 | 9.98 | 15 | 92522 | 25216 | 56174314 |
Purpura | 11.18 | 9.98 | 40 | 92497 | 10322 | 56189208 |
Cardiac failure | 11.14 | 9.98 | 84 | 92453 | 82009 | 56117521 |
Lung diffusion test decreased | 11.07 | 9.98 | 9 | 92528 | 656 | 56198874 |
Dehydration | 11.05 | 9.98 | 189 | 92348 | 158636 | 56040894 |
Genital ulceration | 11.03 | 9.98 | 8 | 92529 | 492 | 56199038 |
Normal newborn | 10.93 | 9.98 | 32 | 92505 | 7438 | 56192092 |
Hypertransaminasaemia | 10.91 | 9.98 | 24 | 92513 | 4683 | 56194847 |
Encephalitis protozoal | 10.89 | 9.98 | 3 | 92534 | 15 | 56199515 |
Otitis media fungal | 10.89 | 9.98 | 3 | 92534 | 15 | 56199515 |
Hypoventilation | 10.87 | 9.98 | 23 | 92514 | 4369 | 56195161 |
Drug ineffective | 10.81 | 9.98 | 1335 | 91202 | 917654 | 55281876 |
Ureteric perforation | 10.73 | 9.98 | 3 | 92534 | 16 | 56199514 |
Catarrh | 10.66 | 9.98 | 7 | 92530 | 366 | 56199164 |
HIV-associated neurocognitive disorder | 10.66 | 9.98 | 5 | 92532 | 134 | 56199396 |
Hyperbilirubinaemia | 10.62 | 9.98 | 39 | 92498 | 10196 | 56189334 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 10.59 | 9.98 | 7 | 92530 | 370 | 56199160 |
Angina bullosa haemorrhagica | 10.49 | 9.98 | 5 | 92532 | 139 | 56199391 |
Immunosuppressant drug level increased | 10.44 | 9.98 | 19 | 92518 | 3234 | 56196296 |
SJS-TEN overlap | 10.37 | 9.98 | 6 | 92531 | 250 | 56199280 |
Bacterial infection | 10.34 | 9.98 | 56 | 92481 | 17274 | 56182256 |
Vulvovaginal candidiasis | 10.30 | 9.98 | 18 | 92519 | 2968 | 56196562 |
Amaurosis | 10.30 | 9.98 | 8 | 92529 | 546 | 56198984 |
Rash maculo-papular | 10.26 | 9.98 | 82 | 92455 | 28825 | 56170705 |
Photodermatosis | 10.25 | 9.98 | 7 | 92530 | 391 | 56199139 |
Basal cell carcinoma | 10.23 | 9.98 | 16 | 92521 | 25205 | 56174325 |
Blood pressure diastolic decreased | 10.21 | 9.98 | 10 | 92527 | 19313 | 56180217 |
Intestinal anastomosis | 10.10 | 9.98 | 7 | 92530 | 400 | 56199130 |
ECG signs of myocardial ischaemia | 10.09 | 9.98 | 4 | 92533 | 70 | 56199460 |
Vaginal abscess | 10.09 | 9.98 | 7 | 92530 | 401 | 56199129 |
Injection site haemorrhage | 10.08 | 9.98 | 13 | 92524 | 22188 | 56177342 |
Joint effusion | 10.05 | 9.98 | 6 | 92531 | 14892 | 56184638 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 2005.94 | 10.56 | 2973 | 62646 | 344301 | 31287424 |
Infective pulmonary exacerbation of cystic fibrosis | 615.15 | 10.56 | 290 | 65329 | 6194 | 31625531 |
Electrocardiogram QT prolonged | 404.20 | 10.56 | 444 | 65175 | 37543 | 31594182 |
Drug hypersensitivity | 202.24 | 10.56 | 457 | 65162 | 72142 | 31559583 |
Asthma | 196.70 | 10.56 | 332 | 65287 | 42279 | 31589446 |
Product use in unapproved indication | 195.24 | 10.56 | 547 | 65072 | 98624 | 31533101 |
Drug ineffective for unapproved indication | 192.63 | 10.56 | 210 | 65409 | 17580 | 31614145 |
Long QT syndrome | 162.86 | 10.56 | 85 | 65534 | 2271 | 31629454 |
Drug interaction | 140.88 | 10.56 | 823 | 64796 | 207720 | 31424005 |
Bronchiectasis | 135.84 | 10.56 | 118 | 65501 | 7462 | 31624263 |
Drug abuse | 134.61 | 10.56 | 13 | 65606 | 87745 | 31543980 |
No adverse event | 130.20 | 10.56 | 181 | 65438 | 19444 | 31612281 |
Immune reconstitution inflammatory syndrome | 128.12 | 10.56 | 118 | 65501 | 8060 | 31623665 |
Hepatitis | 125.23 | 10.56 | 189 | 65430 | 21877 | 31609848 |
Cystic fibrosis | 121.98 | 10.56 | 66 | 65553 | 1900 | 31629825 |
Wheezing | 116.65 | 10.56 | 241 | 65378 | 35745 | 31595980 |
Completed suicide | 112.02 | 10.56 | 26 | 65593 | 91488 | 31540237 |
Hypertransaminasaemia | 111.18 | 10.56 | 83 | 65536 | 4221 | 31627504 |
Obstructive airways disorder | 110.92 | 10.56 | 134 | 65485 | 12530 | 31619195 |
Drug effective for unapproved indication | 110.54 | 10.56 | 61 | 65558 | 1827 | 31629898 |
COVID-19 | 108.32 | 10.56 | 303 | 65316 | 54518 | 31577207 |
Condition aggravated | 104.02 | 10.56 | 637 | 64982 | 163372 | 31468353 |
Productive cough | 103.32 | 10.56 | 220 | 65399 | 33320 | 31598405 |
Fall | 99.98 | 10.56 | 144 | 65475 | 185945 | 31445780 |
Cough | 96.70 | 10.56 | 541 | 65078 | 134273 | 31497452 |
Haemoptysis | 94.41 | 10.56 | 207 | 65412 | 31982 | 31599743 |
Vanishing bile duct syndrome | 88.61 | 10.56 | 37 | 65582 | 584 | 31631141 |
Death | 87.49 | 10.56 | 417 | 65202 | 360152 | 31271573 |
Breath sounds abnormal | 84.35 | 10.56 | 81 | 65538 | 5831 | 31625894 |
Pulmonary function test decreased | 80.06 | 10.56 | 69 | 65550 | 4316 | 31627409 |
Product packaging quantity issue | 78.77 | 10.56 | 37 | 65582 | 782 | 31630943 |
Stevens-Johnson syndrome | 78.29 | 10.56 | 134 | 65485 | 17238 | 31614487 |
Malignant neoplasm progression | 77.85 | 10.56 | 33 | 65586 | 78965 | 31552760 |
Dysplastic naevus | 76.46 | 10.56 | 31 | 65588 | 452 | 31631273 |
Solar lentigo | 75.85 | 10.56 | 31 | 65588 | 462 | 31631263 |
Photodermatosis | 74.78 | 10.56 | 31 | 65588 | 480 | 31631245 |
Pneumonia | 72.69 | 10.56 | 1033 | 64586 | 334279 | 31297446 |
Eosinophil count abnormal | 69.52 | 10.56 | 25 | 65594 | 257 | 31631468 |
Forced expiratory volume decreased | 69.38 | 10.56 | 54 | 65565 | 2923 | 31628802 |
Mycobacterial infection | 68.77 | 10.56 | 48 | 65571 | 2195 | 31629530 |
Congenital hiatus hernia | 67.46 | 10.56 | 30 | 65589 | 556 | 31631169 |
Toxicity to various agents | 65.04 | 10.56 | 178 | 65441 | 181309 | 31450416 |
Mycobacterium avium complex infection | 63.14 | 10.56 | 47 | 65572 | 2379 | 31629346 |
Ototoxicity | 59.53 | 10.56 | 40 | 65579 | 1718 | 31630007 |
Torsade de pointes | 59.19 | 10.56 | 72 | 65547 | 6778 | 31624947 |
Sinusitis | 56.61 | 10.56 | 186 | 65433 | 36510 | 31595215 |
Febrile neutropenia | 55.39 | 10.56 | 105 | 65514 | 121744 | 31509981 |
Mycobacterium abscessus infection | 53.99 | 10.56 | 26 | 65593 | 582 | 31631143 |
Sleep disorder due to a general medical condition | 51.07 | 10.56 | 51 | 65568 | 3851 | 31627874 |
COVID-19 pneumonia | 51.06 | 10.56 | 93 | 65526 | 12562 | 31619163 |
Acute respiratory distress syndrome | 50.77 | 10.56 | 138 | 65481 | 24402 | 31607323 |
Full blood count abnormal | 50.06 | 10.56 | 107 | 65512 | 16240 | 31615485 |
Mucocutaneous disorder | 50.00 | 10.56 | 16 | 65603 | 111 | 31631614 |
Toxic epidermal necrolysis | 49.97 | 10.56 | 119 | 65500 | 19405 | 31612320 |
Rheumatoid arthritis | 48.66 | 10.56 | 19 | 65600 | 47790 | 31583935 |
Sputum increased | 48.03 | 10.56 | 38 | 65581 | 2107 | 31629618 |
Somnolence | 47.59 | 10.56 | 83 | 65536 | 99362 | 31532363 |
Pathogen resistance | 47.19 | 10.56 | 73 | 65546 | 8628 | 31623097 |
Mycobacterium chelonae infection | 46.25 | 10.56 | 25 | 65594 | 718 | 31631007 |
Hepatitis acute | 46.17 | 10.56 | 63 | 65556 | 6646 | 31625079 |
Myocardial infarction | 45.47 | 10.56 | 105 | 65514 | 113349 | 31518376 |
General physical health deterioration | 45.44 | 10.56 | 105 | 65514 | 113330 | 31518395 |
Respiratory disorder | 44.62 | 10.56 | 108 | 65511 | 17792 | 31613933 |
Prostate cancer | 43.44 | 10.56 | 12 | 65607 | 37589 | 31594136 |
Transaminases increased | 42.70 | 10.56 | 129 | 65490 | 24212 | 31607513 |
Bronchitis | 42.66 | 10.56 | 176 | 65443 | 38541 | 31593184 |
Babesiosis | 42.58 | 10.56 | 14 | 65605 | 107 | 31631618 |
Pseudomonas infection | 42.51 | 10.56 | 81 | 65538 | 11320 | 31620405 |
Dizziness | 42.11 | 10.56 | 241 | 65378 | 198906 | 31432819 |
Dehydration | 41.01 | 10.56 | 119 | 65500 | 118992 | 31512733 |
Parathyroid gland enlargement | 40.68 | 10.56 | 14 | 65605 | 125 | 31631600 |
Alanine aminotransferase increased | 40.47 | 10.56 | 279 | 65340 | 74377 | 31557348 |
Cystic fibrosis respiratory infection suppression | 40.18 | 10.56 | 16 | 65603 | 222 | 31631503 |
Upper respiratory fungal infection | 39.54 | 10.56 | 14 | 65605 | 137 | 31631588 |
Constipation | 39.05 | 10.56 | 129 | 65490 | 123862 | 31507863 |
Fatigue | 38.87 | 10.56 | 476 | 65143 | 334730 | 31296995 |
Acute respiratory failure | 38.70 | 10.56 | 137 | 65482 | 27918 | 31603807 |
Respiratory failure | 38.42 | 10.56 | 349 | 65270 | 101100 | 31530625 |
Sputum discoloured | 38.37 | 10.56 | 58 | 65561 | 6718 | 31625007 |
Intentional overdose | 38.10 | 10.56 | 19 | 65600 | 41370 | 31590355 |
Bronchiolitis obliterans syndrome | 37.29 | 10.56 | 14 | 65605 | 164 | 31631561 |
Decreased appetite | 37.09 | 10.56 | 177 | 65442 | 153040 | 31478685 |
Drug resistance | 36.27 | 10.56 | 119 | 65500 | 23334 | 31608391 |
Coma | 36.24 | 10.56 | 20 | 65599 | 41130 | 31590595 |
Forced expiratory volume | 35.08 | 10.56 | 12 | 65607 | 105 | 31631620 |
Bronchopulmonary aspergillosis | 33.70 | 10.56 | 82 | 65537 | 13552 | 31618173 |
Cystic fibrosis related diabetes | 33.62 | 10.56 | 13 | 65606 | 166 | 31631559 |
Cryptococcal meningoencephalitis | 32.97 | 10.56 | 12 | 65607 | 128 | 31631597 |
Obliterative bronchiolitis | 32.89 | 10.56 | 24 | 65595 | 1178 | 31630547 |
Lung transplant rejection | 32.45 | 10.56 | 20 | 65599 | 739 | 31630986 |
Hypertriglyceridaemia | 32.34 | 10.56 | 58 | 65561 | 7740 | 31623985 |
HIV associated nephropathy | 32.24 | 10.56 | 15 | 65604 | 310 | 31631415 |
Pain | 31.88 | 10.56 | 241 | 65378 | 186518 | 31445207 |
COVID-19 treatment | 31.85 | 10.56 | 14 | 65605 | 252 | 31631473 |
Confusional state | 31.69 | 10.56 | 155 | 65464 | 133179 | 31498546 |
Aspergillus infection | 31.39 | 10.56 | 72 | 65547 | 11456 | 31620269 |
Chronic obstructive pulmonary disease | 30.80 | 10.56 | 179 | 65440 | 44987 | 31586738 |
Scleroderma | 29.53 | 10.56 | 24 | 65595 | 1383 | 31630342 |
Lung transplant | 29.32 | 10.56 | 27 | 65592 | 1843 | 31629882 |
Lung diffusion disorder | 28.79 | 10.56 | 10 | 65609 | 92 | 31631633 |
Dyspnoea | 28.67 | 10.56 | 921 | 64698 | 342558 | 31289167 |
Bronchopulmonary aspergillosis allergic | 28.11 | 10.56 | 17 | 65602 | 607 | 31631118 |
Distal intestinal obstruction syndrome | 28.10 | 10.56 | 13 | 65606 | 265 | 31631460 |
Tachyarrhythmia | 27.91 | 10.56 | 34 | 65585 | 3205 | 31628520 |
Product quality issue | 27.89 | 10.56 | 85 | 65534 | 16026 | 31615699 |
Lung hyperinflation | 27.89 | 10.56 | 19 | 65600 | 835 | 31630890 |
Cytokine storm | 27.86 | 10.56 | 17 | 65602 | 617 | 31631108 |
Lip erythema | 27.21 | 10.56 | 8 | 65611 | 40 | 31631685 |
Blood immunoglobulin E increased | 27.08 | 10.56 | 28 | 65591 | 2203 | 31629522 |
Herpes simplex viraemia | 27.01 | 10.56 | 9 | 65610 | 72 | 31631653 |
Hepatocellular injury | 27.00 | 10.56 | 102 | 65517 | 21442 | 31610283 |
Mucormycosis | 26.46 | 10.56 | 44 | 65575 | 5526 | 31626199 |
Overdose | 26.01 | 10.56 | 89 | 65530 | 84575 | 31547150 |
Cryptococcosis | 25.99 | 10.56 | 28 | 65591 | 2310 | 31629415 |
Viral infection | 25.82 | 10.56 | 81 | 65538 | 15512 | 31616213 |
Atypical mycobacterial lower respiratory tract infection | 25.71 | 10.56 | 8 | 65611 | 50 | 31631675 |
Upper-airway cough syndrome | 25.62 | 10.56 | 32 | 65587 | 3095 | 31628630 |
Graft versus host disease in lung | 25.57 | 10.56 | 15 | 65604 | 506 | 31631219 |
Seizure | 25.46 | 10.56 | 113 | 65506 | 99655 | 31532070 |
Neutropenia | 25.44 | 10.56 | 178 | 65441 | 140186 | 31491539 |
Actinic keratosis | 25.43 | 10.56 | 37 | 65582 | 4142 | 31627583 |
Asthenia | 25.29 | 10.56 | 321 | 65298 | 224434 | 31407291 |
Stenotrophomonas infection | 25.17 | 10.56 | 25 | 65594 | 1875 | 31629850 |
Suicide attempt | 25.12 | 10.56 | 24 | 65595 | 37224 | 31594501 |
Rash maculovesicular | 25.07 | 10.56 | 7 | 65612 | 28 | 31631697 |
Cardiac failure | 24.65 | 10.56 | 93 | 65526 | 85860 | 31545865 |
Pharyngeal erythema | 24.54 | 10.56 | 15 | 65604 | 546 | 31631179 |
Gastrointestinal haemorrhage | 24.54 | 10.56 | 88 | 65531 | 82461 | 31549264 |
Hepatitis cholestatic | 24.49 | 10.56 | 49 | 65570 | 7097 | 31624628 |
Pain in extremity | 23.78 | 10.56 | 142 | 65477 | 116061 | 31515664 |
Nasal mucosal disorder | 23.78 | 10.56 | 9 | 65610 | 108 | 31631617 |
Plasma cell myeloma | 23.70 | 10.56 | 51 | 65568 | 56480 | 31575245 |
Conjunctival hyperaemia | 23.70 | 10.56 | 26 | 65593 | 2190 | 31629535 |
Urinary tract infection | 23.48 | 10.56 | 81 | 65538 | 76788 | 31554937 |
Methaemoglobinaemia | 23.42 | 10.56 | 30 | 65589 | 2976 | 31628749 |
Anaemia | 23.26 | 10.56 | 307 | 65312 | 213215 | 31418510 |
Haemolytic anaemia | 23.24 | 10.56 | 58 | 65561 | 9738 | 31621987 |
Chlamydial infection | 23.22 | 10.56 | 10 | 65609 | 171 | 31631554 |
NPM1 gene mutation | 23.13 | 10.56 | 9 | 65610 | 117 | 31631608 |
Blood pressure increased | 22.94 | 10.56 | 86 | 65533 | 79547 | 31552178 |
Liver function test increased | 22.88 | 10.56 | 68 | 65551 | 12646 | 31619079 |
Urethritis mycoplasmal | 22.81 | 10.56 | 6 | 65613 | 18 | 31631707 |
Jaw cyst | 22.81 | 10.56 | 6 | 65613 | 18 | 31631707 |
Cerebrovascular accident | 22.79 | 10.56 | 86 | 65533 | 79398 | 31552327 |
Eosinophilia | 22.75 | 10.56 | 102 | 65517 | 23151 | 31608574 |
HIV infection | 22.74 | 10.56 | 22 | 65597 | 1598 | 31630127 |
Deafness neurosensory | 22.58 | 10.56 | 28 | 65591 | 2688 | 31629037 |
Total lung capacity abnormal | 22.21 | 10.56 | 9 | 65610 | 131 | 31631594 |
Bronchial disorder | 22.17 | 10.56 | 20 | 65599 | 1329 | 31630396 |
Complications of transplanted lung | 22.12 | 10.56 | 10 | 65609 | 193 | 31631532 |
Drug ineffective | 22.10 | 10.56 | 1015 | 64604 | 394558 | 31237167 |
Disseminated cryptococcosis | 22.03 | 10.56 | 20 | 65599 | 1340 | 31630385 |
Wrong technique in product usage process | 21.89 | 10.56 | 22 | 65597 | 33321 | 31598404 |
Malignant melanoma in situ | 21.85 | 10.56 | 20 | 65599 | 1354 | 31630371 |
Pneumonia legionella | 21.82 | 10.56 | 22 | 65597 | 1680 | 31630045 |
Upper respiratory tract infection | 21.63 | 10.56 | 119 | 65500 | 29303 | 31602422 |
Blood pressure fluctuation | 21.59 | 10.56 | 10 | 65609 | 22726 | 31608999 |
Gonorrhoea | 21.46 | 10.56 | 7 | 65612 | 52 | 31631673 |
Injection site pain | 21.45 | 10.56 | 24 | 65595 | 34610 | 31597115 |
Liver injury | 21.35 | 10.56 | 69 | 65550 | 13423 | 31618302 |
Hypoxia | 21.05 | 10.56 | 177 | 65442 | 50136 | 31581589 |
Bronchial hyperreactivity | 20.99 | 10.56 | 20 | 65599 | 1425 | 31630300 |
Cerebral infarction | 20.95 | 10.56 | 14 | 65605 | 25963 | 31605762 |
Deafness | 20.79 | 10.56 | 58 | 65561 | 10407 | 31621318 |
Enterovirus infection | 20.76 | 10.56 | 15 | 65604 | 725 | 31631000 |
Ascites | 20.74 | 10.56 | 33 | 65586 | 40980 | 31590745 |
Carbon dioxide increased | 20.59 | 10.56 | 17 | 65602 | 1002 | 31630723 |
Premature baby | 20.58 | 10.56 | 83 | 65536 | 17983 | 31613742 |
Bladder cancer | 20.53 | 10.56 | 3 | 65616 | 14722 | 31617003 |
Oedema peripheral | 20.53 | 10.56 | 138 | 65481 | 109701 | 31522024 |
Pneumonia mycoplasmal | 20.45 | 10.56 | 14 | 65605 | 620 | 31631105 |
Infective chondritis | 20.44 | 10.56 | 5 | 65614 | 10 | 31631715 |
Hepatic necrosis | 20.24 | 10.56 | 31 | 65588 | 3632 | 31628093 |
Iris adhesions | 20.21 | 10.56 | 10 | 65609 | 238 | 31631487 |
Bacterial pericarditis | 20.10 | 10.56 | 7 | 65612 | 65 | 31631660 |
Contraindicated product administered | 19.88 | 10.56 | 8 | 65611 | 19764 | 31611961 |
Drug reaction with eosinophilia and systemic symptoms | 19.83 | 10.56 | 118 | 65501 | 29900 | 31601825 |
Fungal disease carrier | 19.69 | 10.56 | 10 | 65609 | 252 | 31631473 |
Linear IgA disease | 19.68 | 10.56 | 20 | 65599 | 1542 | 31630183 |
Therapeutic product effect decreased | 19.49 | 10.56 | 22 | 65597 | 31600 | 31600125 |
Disease progression | 18.79 | 10.56 | 110 | 65509 | 90354 | 31541371 |
Pneumothorax | 18.72 | 10.56 | 77 | 65542 | 16833 | 31614892 |
Pulmonary function test abnormal | 18.63 | 10.56 | 23 | 65596 | 2198 | 31629527 |
Mediastinal shift | 18.50 | 10.56 | 4 | 65615 | 3 | 31631722 |
Cardiac failure congestive | 18.43 | 10.56 | 93 | 65526 | 79294 | 31552431 |
Acquired immunodeficiency syndrome | 18.38 | 10.56 | 12 | 65607 | 491 | 31631234 |
Cognitive disorder | 18.08 | 10.56 | 15 | 65604 | 24908 | 31606817 |
Influenza | 18.05 | 10.56 | 155 | 65464 | 44170 | 31587555 |
Lung infiltration | 18.02 | 10.56 | 61 | 65558 | 12152 | 31619573 |
Alcohol intolerance | 18.01 | 10.56 | 11 | 65608 | 400 | 31631325 |
Andersen-Tawil syndrome | 17.97 | 10.56 | 4 | 65615 | 4 | 31631721 |
Nervous system neoplasm | 17.95 | 10.56 | 8 | 65611 | 149 | 31631576 |
Rubber sensitivity | 17.95 | 10.56 | 8 | 65611 | 149 | 31631576 |
Vestibular disorder | 17.92 | 10.56 | 16 | 65603 | 1049 | 31630676 |
Antinuclear antibody negative | 17.91 | 10.56 | 5 | 65614 | 20 | 31631705 |
Arthralgia | 17.86 | 10.56 | 214 | 65405 | 151210 | 31480515 |
Respiratory syncytial virus infection | 17.85 | 10.56 | 30 | 65589 | 3801 | 31627924 |
Lip oedema | 17.80 | 10.56 | 23 | 65596 | 2301 | 31629424 |
Liver function test | 17.69 | 10.56 | 6 | 65613 | 51 | 31631674 |
Acoustic neuroma | 17.57 | 10.56 | 8 | 65611 | 157 | 31631568 |
Myasthenia gravis crisis | 17.56 | 10.56 | 12 | 65607 | 530 | 31631195 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 17.55 | 10.56 | 15 | 65604 | 927 | 31630798 |
Pneumomediastinum | 17.55 | 10.56 | 22 | 65597 | 2135 | 31629590 |
Chimerism | 17.46 | 10.56 | 9 | 65610 | 234 | 31631491 |
Platelet count decreased | 17.20 | 10.56 | 146 | 65473 | 110289 | 31521436 |
Cystic fibrosis lung | 17.20 | 10.56 | 6 | 65613 | 56 | 31631669 |
Restrictive allograft syndrome | 17.17 | 10.56 | 5 | 65614 | 24 | 31631701 |
Tinnitus | 17.15 | 10.56 | 73 | 65546 | 16202 | 31615523 |
Hypercapnia | 17.06 | 10.56 | 30 | 65589 | 3941 | 31627784 |
Osteonecrosis of jaw | 17.01 | 10.56 | 7 | 65612 | 17064 | 31614661 |
Genital ulceration | 16.99 | 10.56 | 8 | 65611 | 170 | 31631555 |
Jarisch-Herxheimer reaction | 16.82 | 10.56 | 11 | 65608 | 451 | 31631274 |
Interstitial lung disease | 16.60 | 10.56 | 68 | 65551 | 61335 | 31570390 |
Oral mucosa erosion | 16.41 | 10.56 | 14 | 65605 | 863 | 31630862 |
Rhodococcus infection | 16.34 | 10.56 | 8 | 65611 | 186 | 31631539 |
Contusion | 16.30 | 10.56 | 27 | 65592 | 33001 | 31598724 |
Rash maculo-papular | 16.29 | 10.56 | 100 | 65519 | 25619 | 31606106 |
Hypotension | 16.29 | 10.56 | 312 | 65307 | 204306 | 31427419 |
Urinary retention | 16.25 | 10.56 | 28 | 65591 | 33697 | 31598028 |
Pancreatic failure | 16.23 | 10.56 | 13 | 65606 | 734 | 31630991 |
SJS-TEN overlap | 16.20 | 10.56 | 9 | 65610 | 273 | 31631452 |
Hepatomegaly | 16.17 | 10.56 | 50 | 65569 | 9500 | 31622225 |
Decreased activity | 16.04 | 10.56 | 29 | 65590 | 3894 | 31627831 |
Palmar-plantar erythrodysaesthesia syndrome | 16.00 | 10.56 | 6 | 65613 | 15477 | 31616248 |
Back pain | 16 | 10.56 | 147 | 65472 | 109266 | 31522459 |
Cerebral toxoplasmosis | 16.00 | 10.56 | 18 | 65601 | 1559 | 31630166 |
Pulmonary alveolar haemorrhage | 15.99 | 10.56 | 40 | 65579 | 6726 | 31624999 |
Secretion discharge | 15.90 | 10.56 | 33 | 65586 | 4904 | 31626821 |
Lung disorder | 15.89 | 10.56 | 118 | 65501 | 32194 | 31599531 |
Glucose-6-phosphate dehydrogenase deficiency | 15.88 | 10.56 | 7 | 65612 | 127 | 31631598 |
Aspartate aminotransferase increased | 15.85 | 10.56 | 199 | 65420 | 62520 | 31569205 |
Tooth discolouration | 15.81 | 10.56 | 10 | 65609 | 387 | 31631338 |
Hypofibrinogenaemia | 15.76 | 10.56 | 18 | 65601 | 1585 | 31630140 |
Lymph node palpable | 15.71 | 10.56 | 5 | 65614 | 34 | 31631691 |
Acute generalised exanthematous pustulosis | 15.65 | 10.56 | 37 | 65582 | 6003 | 31625722 |
Drug-induced liver injury | 15.60 | 10.56 | 95 | 65524 | 24268 | 31607457 |
Mastocytosis | 15.59 | 10.56 | 5 | 65614 | 35 | 31631690 |
Haemoglobin E disease | 15.55 | 10.56 | 3 | 65616 | 0 | 31631725 |
Senile pruritus | 15.55 | 10.56 | 3 | 65616 | 0 | 31631725 |
Chorioretinitis | 15.43 | 10.56 | 10 | 65609 | 404 | 31631321 |
CD4 lymphocytes increased | 15.28 | 10.56 | 8 | 65611 | 215 | 31631510 |
End stage renal disease | 15.19 | 10.56 | 44 | 65575 | 8065 | 31623660 |
Gait disturbance | 15.16 | 10.56 | 96 | 65523 | 77399 | 31554326 |
Pseudomembranous colitis | 15.16 | 10.56 | 23 | 65596 | 2672 | 31629053 |
Respiratory symptom | 15.15 | 10.56 | 16 | 65603 | 1290 | 31630435 |
Oropharyngeal candidiasis | 15.06 | 10.56 | 12 | 65607 | 672 | 31631053 |
Dysarthria | 15.05 | 10.56 | 27 | 65592 | 31990 | 31599735 |
Immunodeficiency common variable | 14.99 | 10.56 | 7 | 65612 | 146 | 31631579 |
ADAMTS13 activity decreased | 14.96 | 10.56 | 6 | 65613 | 85 | 31631640 |
Deafness unilateral | 14.88 | 10.56 | 19 | 65600 | 1879 | 31629846 |
Bronchomalacia | 14.83 | 10.56 | 6 | 65613 | 87 | 31631638 |
Metastases to liver | 14.81 | 10.56 | 4 | 65615 | 12723 | 31619002 |
Hospitalisation | 14.78 | 10.56 | 163 | 65456 | 49644 | 31582081 |
Clostridium difficile colitis | 14.77 | 10.56 | 63 | 65556 | 13993 | 31617732 |
Hyponatraemia | 14.66 | 10.56 | 91 | 65528 | 73708 | 31558017 |
Forced vital capacity decreased | 14.61 | 10.56 | 12 | 65607 | 702 | 31631023 |
Borderline personality disorder | 14.47 | 10.56 | 9 | 65610 | 338 | 31631387 |
Hypocapnia | 14.32 | 10.56 | 7 | 65612 | 162 | 31631563 |
Pneumonia pseudomonal | 14.31 | 10.56 | 26 | 65593 | 3503 | 31628222 |
Palatal oedema | 14.26 | 10.56 | 12 | 65607 | 726 | 31630999 |
Enterobacter infection | 14.15 | 10.56 | 20 | 65599 | 2180 | 31629545 |
Haemoglobin decreased | 14.15 | 10.56 | 157 | 65462 | 112518 | 31519207 |
Bronchopleural fistula | 14.14 | 10.56 | 10 | 65609 | 467 | 31631258 |
Myopia | 14.00 | 10.56 | 14 | 65605 | 1059 | 31630666 |
Syncope | 13.99 | 10.56 | 111 | 65508 | 85071 | 31546654 |
Severe acute respiratory syndrome | 13.94 | 10.56 | 5 | 65614 | 51 | 31631674 |
Atypical mycobacterial infection | 13.91 | 10.56 | 12 | 65607 | 751 | 31630974 |
Pneumonia escherichia | 13.74 | 10.56 | 9 | 65610 | 370 | 31631355 |
Wrong dose | 13.68 | 10.56 | 10 | 65609 | 492 | 31631233 |
Neurological examination abnormal | 13.66 | 10.56 | 8 | 65611 | 269 | 31631456 |
Cytomegalovirus chorioretinitis | 13.58 | 10.56 | 25 | 65594 | 3403 | 31628322 |
Gastrooesophageal reflux disease | 13.56 | 10.56 | 118 | 65501 | 33753 | 31597972 |
Micturition urgency | 13.55 | 10.56 | 34 | 65585 | 5726 | 31625999 |
Tongue discolouration | 13.52 | 10.56 | 14 | 65605 | 1103 | 31630622 |
Disorientation | 13.50 | 10.56 | 27 | 65592 | 30717 | 31601008 |
Viral pharyngitis | 13.50 | 10.56 | 6 | 65613 | 111 | 31631614 |
Chest discomfort | 13.50 | 10.56 | 159 | 65460 | 49210 | 31582515 |
Papillary muscle rupture | 13.47 | 10.56 | 3 | 65616 | 3 | 31631722 |
Neutrophil count decreased | 13.42 | 10.56 | 50 | 65569 | 46344 | 31585381 |
Hypoglycaemia | 13.41 | 10.56 | 57 | 65562 | 50889 | 31580836 |
Haemorrhoids thrombosed | 13.34 | 10.56 | 7 | 65612 | 189 | 31631536 |
Rotavirus infection | 13.32 | 10.56 | 9 | 65610 | 390 | 31631335 |
Rhinalgia | 13.32 | 10.56 | 9 | 65610 | 390 | 31631335 |
Anosmia | 13.32 | 10.56 | 19 | 65600 | 2089 | 31629636 |
Low birth weight baby | 13.23 | 10.56 | 38 | 65581 | 6932 | 31624793 |
Anticoagulation drug level above therapeutic | 13.17 | 10.56 | 18 | 65601 | 1901 | 31629824 |
Cholestasis | 13.15 | 10.56 | 93 | 65526 | 24982 | 31606743 |
Red blood cell sedimentation rate decreased | 13.14 | 10.56 | 5 | 65614 | 61 | 31631664 |
Urinary incontinence | 13.09 | 10.56 | 10 | 65609 | 17310 | 31614415 |
Urosepsis | 13.06 | 10.56 | 4 | 65615 | 11716 | 31620009 |
Rheumatic fever | 13.00 | 10.56 | 4 | 65615 | 24 | 31631701 |
Rash | 12.97 | 10.56 | 525 | 65094 | 200961 | 31430764 |
Hyperkalaemia | 12.96 | 10.56 | 79 | 65540 | 64272 | 31567453 |
Rhinocerebral mucormycosis | 12.90 | 10.56 | 9 | 65610 | 411 | 31631314 |
Pleural fistula | 12.86 | 10.56 | 4 | 65615 | 25 | 31631700 |
Therapeutic product ineffective for unapproved indication | 12.86 | 10.56 | 4 | 65615 | 25 | 31631700 |
Respiratory depression | 12.85 | 10.56 | 7 | 65612 | 14503 | 31617222 |
Prostatic specific antigen increased | 12.78 | 10.56 | 6 | 65613 | 13532 | 31618193 |
Therapeutic response decreased | 12.78 | 10.56 | 22 | 65597 | 26487 | 31605238 |
Flushing | 12.77 | 10.56 | 27 | 65592 | 30101 | 31601624 |
Small intestinal obstruction | 12.67 | 10.56 | 6 | 65613 | 13466 | 31618259 |
Accidental exposure to product | 12.67 | 10.56 | 4 | 65615 | 11491 | 31620234 |
Optic neuropathy | 12.58 | 10.56 | 17 | 65602 | 1776 | 31629949 |
Seborrhoea | 12.52 | 10.56 | 7 | 65612 | 215 | 31631510 |
Folliculitis | 12.52 | 10.56 | 27 | 65592 | 4121 | 31627604 |
Infusion related reaction | 12.50 | 10.56 | 54 | 65565 | 48001 | 31583724 |
Sputum retention | 12.49 | 10.56 | 9 | 65610 | 433 | 31631292 |
Respiratory distress | 12.46 | 10.56 | 115 | 65504 | 33438 | 31598287 |
Eosinophilic pustular folliculitis | 12.39 | 10.56 | 5 | 65614 | 72 | 31631653 |
Lip ulceration | 12.32 | 10.56 | 11 | 65608 | 721 | 31631004 |
Chronic sinusitis | 12.32 | 10.56 | 17 | 65602 | 1812 | 31629913 |
Musculoskeletal stiffness | 12.31 | 10.56 | 44 | 65575 | 41281 | 31590444 |
Achromotrichia congenital | 12.26 | 10.56 | 3 | 65616 | 6 | 31631719 |
Atrial conduction time prolongation | 12.26 | 10.56 | 3 | 65616 | 6 | 31631719 |
Antibiotic associated colitis | 12.26 | 10.56 | 3 | 65616 | 6 | 31631719 |
Cutaneous extramedullary haemopoiesis | 12.26 | 10.56 | 3 | 65616 | 6 | 31631719 |
Adverse event | 12.18 | 10.56 | 10 | 65609 | 16695 | 31615030 |
Occupational exposure to air contaminants | 12.12 | 10.56 | 6 | 65613 | 143 | 31631582 |
Acute myocardial infarction | 12.10 | 10.56 | 59 | 65560 | 50764 | 31580961 |
Prothrombin level decreased | 12.09 | 10.56 | 13 | 65606 | 1070 | 31630655 |
Loss of personal independence in daily activities | 12.08 | 10.56 | 100 | 65519 | 28188 | 31603537 |
Hyperaemia | 12.07 | 10.56 | 13 | 65606 | 1072 | 31630653 |
Tuberculosis gastrointestinal | 12.04 | 10.56 | 7 | 65612 | 232 | 31631493 |
Superinfection bacterial | 11.94 | 10.56 | 11 | 65608 | 751 | 31630974 |
Coronavirus test positive | 11.91 | 10.56 | 9 | 65610 | 466 | 31631259 |
Multiple sclerosis relapse | 11.91 | 10.56 | 5 | 65614 | 12042 | 31619683 |
Eosinophilic pleural effusion | 11.91 | 10.56 | 7 | 65612 | 237 | 31631488 |
Pneumonia acinetobacter | 11.85 | 10.56 | 5 | 65614 | 81 | 31631644 |
Abdominal wall haematoma | 11.85 | 10.56 | 16 | 65603 | 1671 | 31630054 |
Delusion | 11.83 | 10.56 | 5 | 65614 | 11992 | 31619733 |
Acute sinusitis | 11.81 | 10.56 | 14 | 65605 | 1283 | 31630442 |
Kidney infection | 11.80 | 10.56 | 29 | 65590 | 4821 | 31626904 |
Bacterial infection | 11.78 | 10.56 | 58 | 65561 | 13681 | 31618044 |
Blood glucose increased | 11.78 | 10.56 | 76 | 65543 | 61007 | 31570718 |
Memory impairment | 11.76 | 10.56 | 40 | 65579 | 38090 | 31593635 |
Balance disorder | 11.71 | 10.56 | 39 | 65580 | 37383 | 31594342 |
Respiration abnormal | 11.71 | 10.56 | 21 | 65598 | 2801 | 31628924 |
Depressed level of consciousness | 11.56 | 10.56 | 41 | 65578 | 38560 | 31593165 |
Nail pitting | 11.52 | 10.56 | 7 | 65612 | 252 | 31631473 |
Toxic optic neuropathy | 11.51 | 10.56 | 11 | 65608 | 787 | 31630938 |
Tremor | 11.46 | 10.56 | 102 | 65517 | 76318 | 31555407 |
Heart rate decreased | 11.43 | 10.56 | 26 | 65593 | 28240 | 31603485 |
Brain abscess | 11.43 | 10.56 | 21 | 65598 | 2854 | 31628871 |
Rhonchi | 11.43 | 10.56 | 16 | 65603 | 1729 | 31629996 |
Diaphragmatic hernia | 11.42 | 10.56 | 7 | 65612 | 256 | 31631469 |
Neurilemmoma benign | 11.41 | 10.56 | 3 | 65616 | 9 | 31631716 |
Hypo HDL cholesterolaemia | 11.41 | 10.56 | 3 | 65616 | 9 | 31631716 |
Cardiogenic shock | 11.35 | 10.56 | 18 | 65601 | 22390 | 31609335 |
Viral rash | 11.23 | 10.56 | 5 | 65614 | 93 | 31631632 |
Pneumonia staphylococcal | 11.20 | 10.56 | 21 | 65598 | 2899 | 31628826 |
Therapeutic product effect incomplete | 11.19 | 10.56 | 139 | 65480 | 43557 | 31588168 |
Vertical infection transmission | 11.17 | 10.56 | 3 | 65616 | 10 | 31631715 |
Tubulointerstitial nephritis | 11.14 | 10.56 | 71 | 65548 | 18425 | 31613300 |
Eye swelling | 11.13 | 10.56 | 43 | 65576 | 9133 | 31622592 |
Cerebral haemorrhage | 11.11 | 10.56 | 33 | 65586 | 32779 | 31598946 |
Inguinal hernia repair | 11.11 | 10.56 | 7 | 65612 | 269 | 31631456 |
Interstitial granulomatous dermatitis | 11.05 | 10.56 | 6 | 65613 | 174 | 31631551 |
Pneumonia aspiration | 11.03 | 10.56 | 42 | 65577 | 38684 | 31593041 |
Lethargy | 10.95 | 10.56 | 42 | 65577 | 38599 | 31593126 |
Dry gangrene | 10.85 | 10.56 | 8 | 65611 | 399 | 31631326 |
Syphilis | 10.83 | 10.56 | 8 | 65611 | 400 | 31631325 |
Sedation | 10.83 | 10.56 | 14 | 65605 | 18951 | 31612774 |
Acute hepatic failure | 10.82 | 10.56 | 54 | 65565 | 12805 | 31618920 |
Muscle spasms | 10.77 | 10.56 | 90 | 65529 | 68228 | 31563497 |
Incorrect product administration duration | 10.76 | 10.56 | 26 | 65593 | 4276 | 31627449 |
Purpura senile | 10.74 | 10.56 | 3 | 65616 | 12 | 31631713 |
Impaired quality of life | 10.74 | 10.56 | 23 | 65596 | 3493 | 31628232 |
Presyncope | 10.74 | 10.56 | 12 | 65607 | 17316 | 31614409 |
Bronchospasm | 10.71 | 10.56 | 45 | 65574 | 9927 | 31621798 |
Hilar lymphadenopathy | 10.68 | 10.56 | 11 | 65608 | 862 | 31630863 |
Drug level increased | 10.66 | 10.56 | 75 | 65544 | 20111 | 31611614 |
Hepatotoxicity | 10.66 | 10.56 | 72 | 65547 | 19054 | 31612671 |
Angina pectoris | 10.64 | 10.56 | 29 | 65590 | 29612 | 31602113 |
Tendon disorder | 10.63 | 10.56 | 19 | 65600 | 2529 | 31629196 |
Device malfunction | 10.62 | 10.56 | 3 | 65616 | 9263 | 31622462 |
Hypogammaglobulinaemia | 10.58 | 10.56 | 34 | 65585 | 6593 | 31625132 |
Bronchoalveolar lavage | 10.57 | 10.56 | 4 | 65615 | 48 | 31631677 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 2618.93 | 9.78 | 4781 | 125652 | 738279 | 70059732 |
Infective pulmonary exacerbation of cystic fibrosis | 1152.19 | 9.78 | 524 | 129909 | 11634 | 70786377 |
Drug hypersensitivity | 667.10 | 9.78 | 1482 | 128951 | 260977 | 70537034 |
Electrocardiogram QT prolonged | 597.51 | 9.78 | 752 | 129681 | 82765 | 70715246 |
Abortion incomplete | 519.79 | 9.78 | 200 | 130233 | 2862 | 70795149 |
Asthma | 426.82 | 9.78 | 783 | 129650 | 120010 | 70678001 |
Cystic fibrosis | 314.86 | 9.78 | 155 | 130278 | 4126 | 70793885 |
Completed suicide | 298.97 | 9.78 | 34 | 130399 | 227101 | 70570910 |
Product use in unapproved indication | 298.50 | 9.78 | 949 | 129484 | 206529 | 70591482 |
Rheumatoid arthritis | 292.10 | 9.78 | 87 | 130346 | 291718 | 70506293 |
Drug ineffective for unapproved indication | 273.78 | 9.78 | 346 | 130087 | 38192 | 70759819 |
Wheezing | 267.47 | 9.78 | 557 | 129876 | 93613 | 70704398 |
Bronchiectasis | 259.08 | 9.78 | 224 | 130209 | 15873 | 70782138 |
Long QT syndrome | 229.00 | 9.78 | 135 | 130298 | 5192 | 70792819 |
Drug interaction | 223.25 | 9.78 | 1329 | 129104 | 380112 | 70417899 |
COVID-19 | 220.92 | 9.78 | 554 | 129879 | 105203 | 70692808 |
Synovitis | 184.19 | 9.78 | 14 | 130419 | 129214 | 70668797 |
Joint swelling | 178.02 | 9.78 | 124 | 130309 | 253087 | 70544924 |
Cough | 175.90 | 9.78 | 1111 | 129322 | 324266 | 70473745 |
Contraindicated product administered | 172.49 | 9.78 | 22 | 130411 | 134590 | 70663421 |
Haemoptysis | 170.87 | 9.78 | 325 | 130108 | 51127 | 70746884 |
Drug abuse | 170.67 | 9.78 | 32 | 130401 | 147224 | 70650787 |
Pneumonia | 157.89 | 9.78 | 1732 | 128701 | 594500 | 70203511 |
Productive cough | 155.89 | 9.78 | 403 | 130030 | 77934 | 70720077 |
Arthralgia | 151.26 | 9.78 | 451 | 129982 | 502939 | 70295072 |
Sleep disorder due to a general medical condition | 151.07 | 9.78 | 137 | 130296 | 10339 | 70787672 |
Therapeutic product effect decreased | 144.14 | 9.78 | 42 | 130391 | 142976 | 70655035 |
Fall | 142.11 | 9.78 | 386 | 130047 | 443710 | 70354301 |
Pulmonary function test decreased | 141.71 | 9.78 | 110 | 130323 | 6691 | 70791320 |
Obstructive airways disorder | 139.20 | 9.78 | 204 | 130229 | 25909 | 70772102 |
Hand deformity | 130.26 | 9.78 | 7 | 130426 | 86475 | 70711536 |
Immune reconstitution inflammatory syndrome | 124.48 | 9.78 | 136 | 130297 | 12854 | 70785157 |
Cholecystitis chronic | 122.40 | 9.78 | 116 | 130317 | 9260 | 70788751 |
Sputum discoloured | 120.97 | 9.78 | 161 | 130272 | 18690 | 70779321 |
Breath sounds abnormal | 120.70 | 9.78 | 135 | 130298 | 13096 | 70784915 |
Mycobacterium avium complex infection | 119.96 | 9.78 | 83 | 130350 | 4223 | 70793788 |
Drug effective for unapproved indication | 119.03 | 9.78 | 85 | 130348 | 4550 | 70793461 |
Premature delivery | 114.38 | 9.78 | 167 | 130266 | 21137 | 70776874 |
Respiratory failure | 112.96 | 9.78 | 610 | 129823 | 168125 | 70629886 |
Toxicity to various agents | 111.39 | 9.78 | 347 | 130086 | 381825 | 70416186 |
Stevens-Johnson syndrome | 110.89 | 9.78 | 220 | 130213 | 35687 | 70762324 |
Hypertransaminasaemia | 109.86 | 9.78 | 107 | 130326 | 8836 | 70789175 |
Hepatitis | 109.77 | 9.78 | 267 | 130166 | 49713 | 70748298 |
Arthropathy | 106.03 | 9.78 | 73 | 130360 | 149984 | 70648027 |
Fatigue | 104.73 | 9.78 | 991 | 129442 | 823328 | 69974683 |
Full blood count abnormal | 102.74 | 9.78 | 206 | 130227 | 33672 | 70764339 |
Alopecia | 101.01 | 9.78 | 130 | 130303 | 198360 | 70599651 |
Torsade de pointes | 100.15 | 9.78 | 144 | 130289 | 17972 | 70780039 |
Acute respiratory distress syndrome | 99.95 | 9.78 | 229 | 130204 | 41025 | 70756986 |
Systemic lupus erythematosus | 98.93 | 9.78 | 32 | 130401 | 101870 | 70696141 |
Intentional overdose | 97.18 | 9.78 | 30 | 130403 | 98405 | 70699606 |
Pathogen resistance | 97.11 | 9.78 | 121 | 130312 | 13158 | 70784853 |
Chronic obstructive pulmonary disease | 97.06 | 9.78 | 339 | 130094 | 77302 | 70720709 |
Infusion related reaction | 96.83 | 9.78 | 133 | 130300 | 197401 | 70600610 |
Malignant neoplasm progression | 96.07 | 9.78 | 52 | 130381 | 121687 | 70676324 |
Forced expiratory volume decreased | 94.55 | 9.78 | 90 | 130343 | 7224 | 70790787 |
Haemorrhage | 92.15 | 9.78 | 351 | 130082 | 83464 | 70714547 |
Injury | 91.40 | 9.78 | 296 | 130137 | 64949 | 70733062 |
Upper respiratory tract infection | 90.48 | 9.78 | 336 | 130097 | 78938 | 70719073 |
Glossodynia | 87.86 | 9.78 | 25 | 130408 | 86462 | 70711549 |
No adverse event | 85.21 | 9.78 | 185 | 130248 | 31968 | 70766043 |
Mycobacterial infection | 85.08 | 9.78 | 62 | 130371 | 3426 | 70794585 |
Vanishing bile duct syndrome | 84.71 | 9.78 | 44 | 130389 | 1315 | 70796696 |
Hypoxia | 84.44 | 9.78 | 368 | 130065 | 92976 | 70705035 |
Photodermatosis | 81.05 | 9.78 | 38 | 130395 | 905 | 70797106 |
Swelling | 79.92 | 9.78 | 140 | 130293 | 188399 | 70609612 |
Solar lentigo | 79.87 | 9.78 | 39 | 130394 | 1019 | 70796992 |
Wound | 79.63 | 9.78 | 41 | 130392 | 98691 | 70699320 |
COVID-19 pneumonia | 79.46 | 9.78 | 144 | 130289 | 21825 | 70776186 |
Emotional distress | 77.77 | 9.78 | 195 | 130238 | 36993 | 70761018 |
Transaminases increased | 76.72 | 9.78 | 225 | 130208 | 46793 | 70751218 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 76.19 | 9.78 | 43 | 130390 | 1521 | 70796490 |
Somnolence | 76.12 | 9.78 | 178 | 130255 | 215428 | 70582583 |
Cystic fibrosis respiratory infection suppression | 75.93 | 9.78 | 29 | 130404 | 406 | 70797605 |
Dysplastic naevus | 75.47 | 9.78 | 31 | 130402 | 531 | 70797480 |
Drug intolerance | 74.44 | 9.78 | 193 | 130240 | 225494 | 70572517 |
Drug resistance | 74.43 | 9.78 | 195 | 130238 | 37995 | 70760016 |
Helicobacter infection | 73.99 | 9.78 | 8 | 130425 | 55648 | 70742363 |
Dyspnoea | 73.73 | 9.78 | 1894 | 128539 | 768166 | 70029845 |
Death | 73.53 | 9.78 | 593 | 129840 | 509468 | 70288543 |
Ototoxicity | 71.11 | 9.78 | 52 | 130381 | 2889 | 70795122 |
Eosinophilia | 70.69 | 9.78 | 198 | 130235 | 40121 | 70757890 |
Sputum increased | 70.29 | 9.78 | 59 | 130374 | 4013 | 70793998 |
Condition aggravated | 70.19 | 9.78 | 1140 | 129293 | 426495 | 70371516 |
Bronchopulmonary aspergillosis | 70.12 | 9.78 | 133 | 130300 | 20869 | 70777142 |
Mycobacterium abscessus infection | 69.73 | 9.78 | 38 | 130395 | 1254 | 70796757 |
Toxic epidermal necrolysis | 69.10 | 9.78 | 194 | 130239 | 39363 | 70758648 |
Eosinophil count abnormal | 68.65 | 9.78 | 30 | 130403 | 603 | 70797408 |
Congenital hiatus hernia | 68.54 | 9.78 | 29 | 130404 | 537 | 70797474 |
Mobility decreased | 66.47 | 9.78 | 55 | 130378 | 102944 | 70695067 |
Acute generalised exanthematous pustulosis | 66.27 | 9.78 | 109 | 130324 | 15288 | 70782723 |
Exposure during pregnancy | 66.20 | 9.78 | 328 | 130105 | 87389 | 70710622 |
Bronchitis | 66.07 | 9.78 | 405 | 130028 | 116838 | 70681173 |
Rhinitis allergic | 65.26 | 9.78 | 83 | 130350 | 9212 | 70788799 |
Drug reaction with eosinophilia and systemic symptoms | 62.97 | 9.78 | 242 | 130191 | 57771 | 70740240 |
Peripheral swelling | 62.51 | 9.78 | 224 | 130209 | 236339 | 70561672 |
Febrile neutropenia | 61.22 | 9.78 | 183 | 130250 | 204135 | 70593876 |
Confusional state | 61.02 | 9.78 | 292 | 130141 | 284106 | 70513905 |
Pseudomonas infection | 59.39 | 9.78 | 117 | 130316 | 18877 | 70779134 |
Suicide attempt | 58.42 | 9.78 | 37 | 130396 | 79473 | 70718538 |
Infective exacerbation of bronchiectasis | 57.40 | 9.78 | 28 | 130405 | 730 | 70797281 |
Musculoskeletal stiffness | 57.08 | 9.78 | 116 | 130317 | 147644 | 70650367 |
Biliary dyskinesia | 57.06 | 9.78 | 42 | 130391 | 2357 | 70795654 |
Drug-induced liver injury | 56.80 | 9.78 | 229 | 130204 | 55884 | 70742127 |
Factor V inhibition | 55.74 | 9.78 | 22 | 130411 | 338 | 70797673 |
Alanine aminotransferase increased | 54.91 | 9.78 | 461 | 129972 | 147019 | 70650992 |
Overdose | 53.81 | 9.78 | 148 | 130285 | 169597 | 70628414 |
Coma | 53.37 | 9.78 | 54 | 130379 | 91790 | 70706221 |
Deafness | 53.37 | 9.78 | 113 | 130320 | 19190 | 70778821 |
Lip oedema | 52.70 | 9.78 | 58 | 130375 | 5525 | 70792486 |
Bronchopulmonary aspergillosis allergic | 52.62 | 9.78 | 37 | 130396 | 1932 | 70796079 |
Pericarditis | 52.50 | 9.78 | 47 | 130386 | 84658 | 70713353 |
Stomatitis | 52.13 | 9.78 | 98 | 130335 | 128413 | 70669598 |
Product packaging quantity issue | 51.88 | 9.78 | 30 | 130403 | 1112 | 70796899 |
COVID-19 treatment | 50.81 | 9.78 | 22 | 130411 | 432 | 70797579 |
Obliterative bronchiolitis | 50.57 | 9.78 | 42 | 130391 | 2815 | 70795196 |
Acute respiratory failure | 50.38 | 9.78 | 214 | 130219 | 53451 | 70744560 |
Nasal polyps | 49.88 | 9.78 | 51 | 130382 | 4465 | 70793546 |
Aspergillus infection | 49.86 | 9.78 | 105 | 130328 | 17763 | 70780248 |
Pneumothorax | 49.37 | 9.78 | 131 | 130302 | 25715 | 70772296 |
Hepatitis acute | 48.58 | 9.78 | 90 | 130343 | 13872 | 70784139 |
Neutropenia | 48.43 | 9.78 | 276 | 130157 | 256880 | 70541131 |
Sleep disorder due to general medical condition, insomnia type | 47.84 | 9.78 | 5 | 130428 | 35727 | 70762284 |
Constipation | 47.50 | 9.78 | 271 | 130162 | 252167 | 70545844 |
Myasthenia gravis crisis | 47.36 | 9.78 | 27 | 130406 | 974 | 70797037 |
Cystic fibrosis related diabetes | 46.95 | 9.78 | 17 | 130416 | 203 | 70797808 |
Dehydration | 46.86 | 9.78 | 235 | 130198 | 225907 | 70572104 |
Stenotrophomonas infection | 46.73 | 9.78 | 43 | 130390 | 3306 | 70794705 |
Mucocutaneous disorder | 46.34 | 9.78 | 15 | 130418 | 124 | 70797887 |
Total lung capacity increased | 46.08 | 9.78 | 26 | 130407 | 919 | 70797092 |
Chest discomfort | 45.87 | 9.78 | 388 | 130045 | 123993 | 70674018 |
Distal intestinal obstruction syndrome | 45.29 | 9.78 | 23 | 130410 | 655 | 70797356 |
Discomfort | 44.92 | 9.78 | 78 | 130355 | 105358 | 70692653 |
Pulmonary embolism | 44.82 | 9.78 | 461 | 129972 | 155406 | 70642605 |
Lung transplant rejection | 44.19 | 9.78 | 29 | 130404 | 1351 | 70796660 |
Hypertriglyceridaemia | 43.45 | 9.78 | 78 | 130355 | 11733 | 70786278 |
Actinic keratosis | 42.58 | 9.78 | 52 | 130381 | 5538 | 70792473 |
Babesiosis | 42.21 | 9.78 | 18 | 130415 | 340 | 70797671 |
Respiration abnormal | 41.56 | 9.78 | 57 | 130376 | 6807 | 70791204 |
Blood pressure fluctuation | 41.27 | 9.78 | 29 | 130404 | 58983 | 70739028 |
Cognitive disorder | 41.27 | 9.78 | 31 | 130402 | 60925 | 70737086 |
Lung opacity | 41.13 | 9.78 | 42 | 130391 | 3671 | 70794340 |
Hepatocellular injury | 41.12 | 9.78 | 181 | 130252 | 45910 | 70752101 |
Dizziness | 40.90 | 9.78 | 604 | 129829 | 463537 | 70334474 |
Hepatitis cholestatic | 40.86 | 9.78 | 79 | 130354 | 12571 | 70785440 |
Urinary tract infection | 40.63 | 9.78 | 279 | 130154 | 248490 | 70549521 |
Hypofibrinogenaemia | 40.07 | 9.78 | 31 | 130402 | 1876 | 70796135 |
Eosinophilic pneumonia | 39.61 | 9.78 | 47 | 130386 | 4858 | 70793153 |
Impaired healing | 39.60 | 9.78 | 47 | 130386 | 74327 | 70723684 |
Bronchomalacia | 39.47 | 9.78 | 15 | 130418 | 207 | 70797804 |
Bronchiolitis obliterans syndrome | 39.28 | 9.78 | 16 | 130417 | 268 | 70797743 |
Injection site pain | 39.20 | 9.78 | 100 | 130333 | 117519 | 70680492 |
Pneumomediastinum | 38.94 | 9.78 | 39 | 130394 | 3331 | 70794680 |
Anosmia | 38.14 | 9.78 | 46 | 130387 | 4837 | 70793174 |
Contusion | 38.10 | 9.78 | 115 | 130318 | 127921 | 70670090 |
Auscultation | 37.10 | 9.78 | 7 | 130426 | 0 | 70798011 |
Irritable bowel syndrome | 36.89 | 9.78 | 24 | 130409 | 50826 | 70747185 |
Pulmonary function test abnormal | 36.60 | 9.78 | 38 | 130395 | 3387 | 70794624 |
Eosinophil count increased | 36.31 | 9.78 | 84 | 130349 | 15138 | 70782873 |
Gastrointestinal haemorrhage | 35.68 | 9.78 | 131 | 130302 | 137277 | 70660734 |
Hepatic enzyme increased | 34.92 | 9.78 | 159 | 130274 | 156831 | 70641180 |
Heart sounds | 34.74 | 9.78 | 20 | 130413 | 735 | 70797276 |
General physical health deterioration | 34.56 | 9.78 | 273 | 130160 | 235758 | 70562253 |
Pregnancy | 34.30 | 9.78 | 109 | 130324 | 23672 | 70774339 |
Forced expiratory volume | 34.19 | 9.78 | 11 | 130422 | 89 | 70797922 |
Gallbladder disorder | 34.06 | 9.78 | 90 | 130343 | 17622 | 70780389 |
Cholestasis | 33.99 | 9.78 | 176 | 130257 | 47696 | 70750315 |
Sedation | 33.98 | 9.78 | 22 | 130411 | 46709 | 70751302 |
HIV associated nephropathy | 33.81 | 9.78 | 15 | 130418 | 313 | 70797698 |
Prostate cancer | 33.56 | 9.78 | 8 | 130425 | 31155 | 70766856 |
Symmetrical drug-related intertriginous and flexural exanthema | 33.23 | 9.78 | 19 | 130414 | 689 | 70797322 |
Graft versus host disease in lung | 33.21 | 9.78 | 20 | 130413 | 800 | 70797211 |
Parathyroid gland enlargement | 33.17 | 9.78 | 12 | 130421 | 143 | 70797868 |
Atypical mycobacterial infection | 33.17 | 9.78 | 25 | 130408 | 1455 | 70796556 |
Tinnitus | 32.98 | 9.78 | 143 | 130290 | 36033 | 70761978 |
Decreased appetite | 32.93 | 9.78 | 380 | 130053 | 304400 | 70493611 |
Rales | 32.88 | 9.78 | 87 | 130346 | 17048 | 70780963 |
Immunodeficiency common variable | 32.76 | 9.78 | 14 | 130419 | 266 | 70797745 |
Herpes simplex viraemia | 32.71 | 9.78 | 14 | 130419 | 267 | 70797744 |
Chronic sinusitis | 32.62 | 9.78 | 57 | 130376 | 8394 | 70789617 |
Cryptococcosis | 32.31 | 9.78 | 35 | 130398 | 3275 | 70794736 |
Respiratory tract infection | 32.30 | 9.78 | 159 | 130274 | 42239 | 70755772 |
Respiratory disorder | 32.18 | 9.78 | 150 | 130283 | 38973 | 70759038 |
Mucormycosis | 32.18 | 9.78 | 55 | 130378 | 7959 | 70790052 |
Abdominal discomfort | 32.02 | 9.78 | 247 | 130186 | 214411 | 70583600 |
Injection site erythema | 31.93 | 9.78 | 53 | 130380 | 72871 | 70725140 |
Myocardial infarction | 31.87 | 9.78 | 185 | 130248 | 171460 | 70626551 |
Injection site swelling | 31.81 | 9.78 | 20 | 130413 | 43137 | 70754874 |
Hyponatraemia | 31.65 | 9.78 | 169 | 130264 | 159918 | 70638093 |
Hypotension | 31.65 | 9.78 | 538 | 129895 | 403843 | 70394168 |
Osteonecrosis of jaw | 31.63 | 9.78 | 18 | 130415 | 40984 | 70757027 |
Atypical mycobacterial lower respiratory tract infection | 31.63 | 9.78 | 10 | 130423 | 76 | 70797935 |
Viral infection | 31.43 | 9.78 | 147 | 130286 | 38244 | 70759767 |
Pain | 31.29 | 9.78 | 899 | 129534 | 627917 | 70170094 |
Pneumonia legionella | 30.92 | 9.78 | 31 | 130402 | 2651 | 70795360 |
Influenza | 30.66 | 9.78 | 332 | 130101 | 113368 | 70684643 |
Pneumothorax spontaneous | 30.64 | 9.78 | 23 | 130410 | 1330 | 70796681 |
Pain in extremity | 30.61 | 9.78 | 422 | 130011 | 327660 | 70470351 |
Cryptococcal meningoencephalitis | 30.51 | 9.78 | 13 | 130420 | 245 | 70797766 |
Palmar-plantar erythrodysaesthesia syndrome | 30.24 | 9.78 | 9 | 130424 | 30238 | 70767773 |
Deafness neurosensory | 29.97 | 9.78 | 48 | 130385 | 6584 | 70791427 |
Prolonged expiration | 29.70 | 9.78 | 20 | 130413 | 973 | 70797038 |
Cystic fibrosis pancreatic | 29.61 | 9.78 | 9 | 130424 | 59 | 70797952 |
Oral candidiasis | 29.50 | 9.78 | 107 | 130326 | 24845 | 70773166 |
Pneumonia pseudomonal | 29.43 | 9.78 | 42 | 130391 | 5204 | 70792807 |
Orthostatic hypotension | 29.40 | 9.78 | 31 | 130402 | 51712 | 70746299 |
Hypercapnia | 29.37 | 9.78 | 54 | 130379 | 8275 | 70789736 |
Middle lobe syndrome | 29.20 | 9.78 | 8 | 130425 | 34 | 70797977 |
Blood pressure increased | 29.02 | 9.78 | 215 | 130218 | 188302 | 70609709 |
Mycobacterium chelonae infection | 28.50 | 9.78 | 28 | 130405 | 2336 | 70795675 |
Cytokine storm | 28.44 | 9.78 | 19 | 130414 | 912 | 70797099 |
Sopor | 28.31 | 9.78 | 11 | 130422 | 31256 | 70766755 |
Pharyngeal erythema | 28.07 | 9.78 | 25 | 130408 | 1842 | 70796169 |
Hospitalisation | 28.05 | 9.78 | 253 | 130180 | 82315 | 70715696 |
Disease progression | 27.96 | 9.78 | 171 | 130262 | 156501 | 70641510 |
Mixed liver injury | 27.92 | 9.78 | 45 | 130388 | 6204 | 70791807 |
Neutrophil count decreased | 27.10 | 9.78 | 72 | 130361 | 83484 | 70714527 |
Breast cancer | 26.94 | 9.78 | 14 | 130419 | 33535 | 70764476 |
NPM1 gene mutation | 26.85 | 9.78 | 10 | 130423 | 130 | 70797881 |
Hypokalaemia | 26.77 | 9.78 | 137 | 130296 | 131051 | 70666960 |
Factor V deficiency | 26.56 | 9.78 | 9 | 130424 | 87 | 70797924 |
Liver function test increased | 26.55 | 9.78 | 128 | 130305 | 33719 | 70764292 |
Knee arthroplasty | 26.54 | 9.78 | 15 | 130418 | 34286 | 70763725 |
Pneumonia bacterial | 26.53 | 9.78 | 79 | 130354 | 16562 | 70781449 |
Therapeutic product effect incomplete | 26.53 | 9.78 | 337 | 130096 | 119545 | 70678466 |
Cardiac failure | 26.49 | 9.78 | 155 | 130278 | 143386 | 70654625 |
Seizure | 26.43 | 9.78 | 205 | 130228 | 177757 | 70620254 |
Disseminated mycobacterium avium complex infection | 26.38 | 9.78 | 11 | 130422 | 196 | 70797815 |
SJS-TEN overlap | 26.34 | 9.78 | 15 | 130418 | 540 | 70797471 |
Lung diffusion disorder | 26.31 | 9.78 | 10 | 130423 | 138 | 70797873 |
Gait disturbance | 26.21 | 9.78 | 216 | 130217 | 184890 | 70613121 |
Platelet count decreased | 26.14 | 9.78 | 206 | 130227 | 178016 | 70619995 |
Cardiac arrest | 26.09 | 9.78 | 426 | 130007 | 159408 | 70638603 |
Cystic fibrosis lung | 26.05 | 9.78 | 10 | 130423 | 142 | 70797869 |
Aspartate aminotransferase increased | 26.03 | 9.78 | 352 | 130081 | 126626 | 70671385 |
Agranulocytosis | 25.79 | 9.78 | 144 | 130289 | 40154 | 70757857 |
Dysarthria | 25.72 | 9.78 | 47 | 130386 | 62266 | 70735745 |
C-reactive protein abnormal | 25.63 | 9.78 | 20 | 130413 | 38559 | 70759452 |
Genital ulceration | 25.63 | 9.78 | 16 | 130417 | 683 | 70797328 |
Metastases to bone | 25.61 | 9.78 | 5 | 130428 | 22371 | 70775640 |
Rash maculo-papular | 25.61 | 9.78 | 170 | 130263 | 50375 | 70747636 |
Adverse event | 25.54 | 9.78 | 32 | 130401 | 49429 | 70748582 |
Metastases to liver | 25.33 | 9.78 | 8 | 130425 | 25870 | 70772141 |
Rash maculovesicular | 25.32 | 9.78 | 7 | 130426 | 31 | 70797980 |
Blood immunoglobulin E increased | 25.19 | 9.78 | 37 | 130396 | 4707 | 70793304 |
Alveolitis | 25.14 | 9.78 | 33 | 130400 | 3778 | 70794233 |
Mechanical urticaria | 25.13 | 9.78 | 13 | 130420 | 385 | 70797626 |
Forced vital capacity decreased | 25.10 | 9.78 | 22 | 130411 | 1587 | 70796424 |
Joint stiffness | 24.98 | 9.78 | 17 | 130416 | 35159 | 70762852 |
Lung infiltration | 24.95 | 9.78 | 92 | 130341 | 21532 | 70776479 |
Methaemoglobinaemia | 24.94 | 9.78 | 37 | 130396 | 4749 | 70793262 |
Upper respiratory fungal infection | 24.70 | 9.78 | 12 | 130421 | 310 | 70797701 |
Blister | 24.70 | 9.78 | 98 | 130335 | 100428 | 70697583 |
Tachyarrhythmia | 24.58 | 9.78 | 43 | 130390 | 6339 | 70791672 |
Oropharyngeal pain | 24.49 | 9.78 | 278 | 130155 | 96032 | 70701979 |
Cholelithiasis | 24.46 | 9.78 | 160 | 130273 | 47180 | 70750831 |
Asthenia | 24.09 | 9.78 | 649 | 129784 | 457017 | 70340994 |
Headache | 23.99 | 9.78 | 850 | 129583 | 579555 | 70218456 |
Endometritis | 23.93 | 9.78 | 16 | 130417 | 769 | 70797242 |
Joint range of motion decreased | 23.83 | 9.78 | 9 | 130424 | 26017 | 70771994 |
Respiratory syncytial virus infection | 23.74 | 9.78 | 47 | 130386 | 7608 | 70790403 |
Accidental exposure to product | 23.59 | 9.78 | 11 | 130422 | 28040 | 70769971 |
Depressed level of consciousness | 23.59 | 9.78 | 82 | 130351 | 87349 | 70710662 |
Complications of transplanted lung | 23.55 | 9.78 | 13 | 130420 | 440 | 70797571 |
Urethritis mycoplasmal | 23.52 | 9.78 | 6 | 130427 | 18 | 70797993 |
White blood cell count decreased | 23.43 | 9.78 | 200 | 130233 | 169941 | 70628070 |
Device expulsion | 23.40 | 9.78 | 6 | 130427 | 22240 | 70775771 |
Pneumonia mycoplasmal | 23.32 | 9.78 | 20 | 130413 | 1401 | 70796610 |
Conjunctival hyperaemia | 23.31 | 9.78 | 33 | 130400 | 4060 | 70793951 |
Total lung capacity decreased | 23.14 | 9.78 | 23 | 130410 | 1946 | 70796065 |
Mucosal inflammation | 23.13 | 9.78 | 57 | 130376 | 67793 | 70730218 |
Bronchial wall thickening | 22.97 | 9.78 | 24 | 130409 | 2155 | 70795856 |
Tachypnoea | 22.97 | 9.78 | 109 | 130324 | 28529 | 70769482 |
Iris transillumination defect | 22.94 | 9.78 | 9 | 130424 | 136 | 70797875 |
Sputum retention | 22.83 | 9.78 | 17 | 130416 | 971 | 70797040 |
Chlamydial infection | 22.72 | 9.78 | 13 | 130420 | 472 | 70797539 |
Ventricular tachycardia | 22.54 | 9.78 | 129 | 130304 | 36294 | 70761717 |
Treatment failure | 22.37 | 9.78 | 164 | 130269 | 143978 | 70654033 |
Lung transplant | 22.12 | 9.78 | 33 | 130400 | 4257 | 70793754 |
Pancreatic failure | 22.11 | 9.78 | 20 | 130413 | 1504 | 70796507 |
Rhinocerebral mucormycosis | 22.07 | 9.78 | 15 | 130418 | 741 | 70797270 |
Injection site reaction | 22.04 | 9.78 | 36 | 130397 | 49816 | 70748195 |
Pharyngeal enanthema | 21.83 | 9.78 | 7 | 130426 | 56 | 70797955 |
Uterine perforation | 21.79 | 9.78 | 39 | 130394 | 5852 | 70792159 |
Bladder cancer | 21.64 | 9.78 | 3 | 130430 | 17239 | 70780772 |
Folliculitis | 21.51 | 9.78 | 28 | 130405 | 42542 | 70755469 |
Upper-airway cough syndrome | 21.37 | 9.78 | 52 | 130381 | 9679 | 70788332 |
Injection site bruising | 21.37 | 9.78 | 23 | 130410 | 38009 | 70760002 |
Chronic kidney disease | 21.21 | 9.78 | 188 | 130245 | 60869 | 70737142 |
Hyperbilirubinaemia | 21.18 | 9.78 | 90 | 130343 | 22478 | 70775533 |
Lung disorder | 21.15 | 9.78 | 208 | 130225 | 69276 | 70728735 |
Hypertension | 20.88 | 9.78 | 401 | 130032 | 295632 | 70502379 |
Emphysema | 20.78 | 9.78 | 68 | 130365 | 14992 | 70783019 |
Pelvic inflammatory disease | 20.78 | 9.78 | 18 | 130415 | 1278 | 70796733 |
Urticaria | 20.77 | 9.78 | 418 | 130015 | 162631 | 70635380 |
Flank pain | 20.64 | 9.78 | 75 | 130358 | 17427 | 70780584 |
Bacterial infection | 20.64 | 9.78 | 100 | 130333 | 26392 | 70771619 |
Bacterial pericarditis | 20.45 | 9.78 | 7 | 130426 | 70 | 70797941 |
Rheumatoid factor | 20.26 | 9.78 | 8 | 130425 | 123 | 70797888 |
Small intestinal obstruction | 20.23 | 9.78 | 10 | 130423 | 24645 | 70773366 |
Cerebral infarction | 20.02 | 9.78 | 30 | 130403 | 42979 | 70755032 |
Therapeutic response decreased | 20.01 | 9.78 | 49 | 130384 | 58404 | 70739607 |
Injection site haemorrhage | 19.99 | 9.78 | 11 | 130422 | 25516 | 70772495 |
Chimerism | 19.78 | 9.78 | 10 | 130423 | 282 | 70797729 |
Hallucinations, mixed | 19.66 | 9.78 | 39 | 130394 | 6323 | 70791688 |
Balance disorder | 19.61 | 9.78 | 92 | 130341 | 90036 | 70707975 |
Granulomatosis with polyangiitis | 19.49 | 9.78 | 24 | 130409 | 2578 | 70795433 |
Anhedonia | 19.46 | 9.78 | 64 | 130369 | 14149 | 70783862 |
Dystonia | 19.45 | 9.78 | 6 | 130427 | 19700 | 70778311 |
Psoriatic arthropathy | 19.39 | 9.78 | 58 | 130375 | 64713 | 70733298 |
Meningism | 19.29 | 9.78 | 13 | 130420 | 633 | 70797378 |
Fungal disease carrier | 19.22 | 9.78 | 10 | 130423 | 300 | 70797711 |
Jarisch-Herxheimer reaction | 19.17 | 9.78 | 14 | 130419 | 776 | 70797235 |
Ascites | 19.15 | 9.78 | 62 | 130371 | 67485 | 70730526 |
Gastrooesophageal reflux disease | 19.10 | 9.78 | 253 | 130180 | 90586 | 70707425 |
Amniotic cavity infection | 18.81 | 9.78 | 14 | 130419 | 799 | 70797212 |
Erythema multiforme | 18.71 | 9.78 | 70 | 130363 | 16494 | 70781517 |
Drug level increased | 18.68 | 9.78 | 123 | 130310 | 36346 | 70761665 |
Pneumonia necrotising | 18.55 | 9.78 | 15 | 130418 | 968 | 70797043 |
Antinuclear antibody negative | 18.49 | 9.78 | 5 | 130428 | 20 | 70797991 |
Pneumonia aspiration | 18.48 | 9.78 | 56 | 130377 | 62233 | 70735778 |
Tubulointerstitial nephritis | 18.45 | 9.78 | 114 | 130319 | 32962 | 70765049 |
Andersen-Tawil syndrome | 18.44 | 9.78 | 4 | 130429 | 4 | 70798007 |
Gallbladder cholesterolosis | 18.38 | 9.78 | 12 | 130421 | 554 | 70797457 |
Pancreatitis acute | 18.23 | 9.78 | 144 | 130289 | 45080 | 70752931 |
Lung hyperinflation | 18.22 | 9.78 | 19 | 130414 | 1702 | 70796309 |
Multiple sclerosis relapse | 18.15 | 9.78 | 32 | 130401 | 42985 | 70755026 |
Weight increased | 18.10 | 9.78 | 325 | 130108 | 242006 | 70556005 |
Fracture | 18.09 | 9.78 | 7 | 130426 | 19937 | 70778074 |
Pseudomembranous colitis | 17.85 | 9.78 | 33 | 130400 | 5078 | 70792933 |
Nasal mucosal disorder | 17.84 | 9.78 | 10 | 130423 | 349 | 70797662 |
Respiratory distress | 17.82 | 9.78 | 166 | 130267 | 54484 | 70743527 |
Restrictive allograft syndrome | 17.76 | 9.78 | 5 | 130428 | 24 | 70797987 |
Disseminated cryptococcosis | 17.63 | 9.78 | 19 | 130414 | 1768 | 70796243 |
Dyspnoea exertional | 17.57 | 9.78 | 221 | 130212 | 78209 | 70719802 |
Urethral discharge | 17.55 | 9.78 | 4 | 130429 | 6 | 70798005 |
Foot deformity | 17.53 | 9.78 | 8 | 130425 | 20647 | 70777364 |
Heart rate decreased | 17.52 | 9.78 | 57 | 130376 | 61958 | 70736053 |
Leukocytosis | 17.50 | 9.78 | 129 | 130304 | 39539 | 70758472 |
HIV infection | 17.49 | 9.78 | 17 | 130416 | 1400 | 70796611 |
Pyrexia | 17.40 | 9.78 | 1318 | 129115 | 605634 | 70192377 |
Hepatomegaly | 17.39 | 9.78 | 71 | 130362 | 17421 | 70780590 |
Rhodococcus infection | 17.39 | 9.78 | 9 | 130424 | 267 | 70797744 |
Hypoglycaemia | 17.35 | 9.78 | 102 | 130331 | 94262 | 70703749 |
Malignant melanoma in situ | 17.31 | 9.78 | 20 | 130413 | 2009 | 70796002 |
Crystal arthropathy | 17.20 | 9.78 | 8 | 130425 | 187 | 70797824 |
Carbon dioxide increased | 17.19 | 9.78 | 20 | 130413 | 2025 | 70795986 |
Pulmonary infarction | 17.17 | 9.78 | 26 | 130407 | 3397 | 70794614 |
Vaginal stricture | 17.17 | 9.78 | 4 | 130429 | 7 | 70798004 |
Joint dislocation | 17.16 | 9.78 | 3 | 130430 | 14528 | 70783483 |
Red blood cell sedimentation rate abnormal | 17.14 | 9.78 | 7 | 130426 | 19296 | 70778715 |
Muscular weakness | 17.13 | 9.78 | 167 | 130266 | 138169 | 70659842 |
Respiratory tract congestion | 17.03 | 9.78 | 71 | 130362 | 17582 | 70780429 |
Musculoskeletal pain | 16.95 | 9.78 | 97 | 130336 | 90230 | 70707781 |
Gastroenteritis staphylococcal | 16.91 | 9.78 | 9 | 130424 | 283 | 70797728 |
Enterovirus infection | 16.89 | 9.78 | 18 | 130415 | 1653 | 70796358 |
Infective chondritis | 16.83 | 9.78 | 5 | 130428 | 30 | 70797981 |
Anaemia | 16.82 | 9.78 | 590 | 129843 | 402833 | 70395178 |
Fluid retention | 16.73 | 9.78 | 60 | 130373 | 63325 | 70734686 |
Lip erythema | 16.56 | 9.78 | 8 | 130425 | 204 | 70797807 |
Osteoarthritis | 16.54 | 9.78 | 75 | 130358 | 74072 | 70723939 |
Fibromyalgia | 16.49 | 9.78 | 40 | 130393 | 47834 | 70750177 |
Gallbladder injury | 16.48 | 9.78 | 15 | 130418 | 1137 | 70796874 |
Pneumonia staphylococcal | 16.45 | 9.78 | 30 | 130403 | 4568 | 70793443 |
Urosepsis | 16.44 | 9.78 | 12 | 130421 | 23937 | 70774074 |
Staphylococcal infection | 16.32 | 9.78 | 160 | 130273 | 53244 | 70744767 |
Interstitial lung disease | 16.29 | 9.78 | 119 | 130314 | 104566 | 70693445 |
Kawasaki's disease | 16.21 | 9.78 | 4 | 130429 | 10 | 70798001 |
Cardiac failure congestive | 16.16 | 9.78 | 165 | 130268 | 135292 | 70662719 |
Muscle spasticity | 16.13 | 9.78 | 8 | 130425 | 19681 | 70778330 |
HIV viraemia | 16.11 | 9.78 | 6 | 130427 | 78 | 70797933 |
C-reactive protein increased | 16.08 | 9.78 | 128 | 130305 | 110389 | 70687622 |
Mycoplasma infection | 16.06 | 9.78 | 12 | 130421 | 689 | 70797322 |
Appetite disorder | 16.03 | 9.78 | 38 | 130395 | 6957 | 70791054 |
Poisoning | 15.97 | 9.78 | 11 | 130422 | 22611 | 70775400 |
Thoracic cavity drainage test abnormal | 15.90 | 9.78 | 3 | 130430 | 0 | 70798011 |
Bronchogram abnormal | 15.90 | 9.78 | 3 | 130430 | 0 | 70798011 |
Portal hypertensive enteropathy | 15.90 | 9.78 | 3 | 130430 | 0 | 70798011 |
Noninfective conjunctivitis | 15.81 | 9.78 | 5 | 130428 | 38 | 70797973 |
Haemolysis | 15.80 | 9.78 | 52 | 130381 | 11499 | 70786512 |
Gait inability | 15.79 | 9.78 | 40 | 130393 | 47135 | 70750876 |
Prescribed overdose | 15.76 | 9.78 | 16 | 130417 | 27165 | 70770846 |
Hip arthroplasty | 15.71 | 9.78 | 17 | 130416 | 28023 | 70769988 |
Diabetic ketoacidosis | 15.64 | 9.78 | 21 | 130412 | 31491 | 70766520 |
Blood immunoglobulin G decreased | 15.64 | 9.78 | 23 | 130410 | 2929 | 70795082 |
Staphylococcus test positive | 15.48 | 9.78 | 34 | 130399 | 5920 | 70792091 |
Lower gastrointestinal haemorrhage | 15.42 | 9.78 | 4 | 130429 | 14716 | 70783295 |
Bacterial disease carrier | 15.23 | 9.78 | 14 | 130419 | 1075 | 70796936 |
Basal cell carcinoma | 15.21 | 9.78 | 24 | 130409 | 33674 | 70764337 |
Pigment nephropathy | 15.17 | 9.78 | 5 | 130428 | 44 | 70797967 |
Subcutaneous emphysema | 15.06 | 9.78 | 17 | 130416 | 1665 | 70796346 |
Hepatotoxicity | 15.05 | 9.78 | 135 | 130298 | 43851 | 70754160 |
Peak expiratory flow rate abnormal | 14.87 | 9.78 | 6 | 130427 | 98 | 70797913 |
Impaired quality of life | 14.86 | 9.78 | 43 | 130390 | 8873 | 70789138 |
Macule | 14.84 | 9.78 | 21 | 130412 | 2582 | 70795429 |
Purpura | 14.84 | 9.78 | 69 | 130364 | 17906 | 70780105 |
Increased bronchial secretion | 14.82 | 9.78 | 23 | 130410 | 3070 | 70794941 |
Hyperaemia | 14.80 | 9.78 | 22 | 130411 | 2829 | 70795182 |
Extrapyramidal disorder | 14.77 | 9.78 | 10 | 130423 | 20740 | 70777271 |
Rheumatic fever | 14.74 | 9.78 | 7 | 130426 | 17653 | 70780358 |
Abdominal wall haematoma | 14.72 | 9.78 | 28 | 130405 | 4402 | 70793609 |
Bronchial hyperreactivity | 14.70 | 9.78 | 21 | 130412 | 2605 | 70795406 |
Nosocomial infection | 14.65 | 9.78 | 21 | 130412 | 2612 | 70795399 |
Blood glucose increased | 14.65 | 9.78 | 120 | 130313 | 102862 | 70695149 |
Rash pustular | 14.64 | 9.78 | 47 | 130386 | 10261 | 70787750 |
Gonorrhoea | 14.62 | 9.78 | 7 | 130426 | 175 | 70797836 |
Pancreatic carcinoma | 14.53 | 9.78 | 3 | 130430 | 12901 | 70785110 |
Kounis syndrome | 14.48 | 9.78 | 24 | 130409 | 3387 | 70794624 |
Oral mucosa erosion | 14.40 | 9.78 | 17 | 130416 | 1748 | 70796263 |
Clostridium difficile colitis | 14.37 | 9.78 | 97 | 130336 | 28899 | 70769112 |
Hyperkalaemia | 14.35 | 9.78 | 126 | 130307 | 106465 | 70691546 |
Psoriasis | 14.32 | 9.78 | 114 | 130319 | 98319 | 70699692 |
Acoustic neuroma | 14.30 | 9.78 | 8 | 130425 | 278 | 70797733 |
Total lung capacity abnormal | 14.30 | 9.78 | 7 | 130426 | 184 | 70797827 |
Respiratory tract inflammation | 14.21 | 9.78 | 12 | 130421 | 823 | 70797188 |
Cerebral haemorrhage | 14.21 | 9.78 | 51 | 130382 | 53813 | 70744198 |
Hypogammaglobulinaemia | 14.08 | 9.78 | 50 | 130383 | 11488 | 70786523 |
Blood pressure diastolic decreased | 14.03 | 9.78 | 16 | 130417 | 25764 | 70772247 |
Injection site warmth | 14.03 | 9.78 | 4 | 130429 | 13821 | 70784190 |
Oesophagogastroduodenoscopy | 14.02 | 9.78 | 7 | 130426 | 192 | 70797819 |
Hilar lymphadenopathy | 14.01 | 9.78 | 16 | 130417 | 1587 | 70796424 |
Alcohol intolerance | 13.97 | 9.78 | 9 | 130424 | 406 | 70797605 |
Respiratory depression | 13.97 | 9.78 | 15 | 130418 | 24816 | 70773195 |
Pneumonia pneumococcal | 13.95 | 9.78 | 24 | 130409 | 3490 | 70794521 |
Local reaction | 13.92 | 9.78 | 10 | 130423 | 540 | 70797471 |
Severe acute respiratory syndrome | 13.90 | 9.78 | 6 | 130427 | 117 | 70797894 |
Bronchial secretion retention | 13.89 | 9.78 | 22 | 130411 | 2988 | 70795023 |
Disorientation | 13.89 | 9.78 | 57 | 130376 | 57866 | 70740145 |
Device malfunction | 13.85 | 9.78 | 9 | 130424 | 19075 | 70778936 |
Senile pruritus | 13.83 | 9.78 | 3 | 130430 | 3 | 70798008 |
Myasthenia gravis | 13.81 | 9.78 | 37 | 130396 | 7302 | 70790709 |
Hepatic necrosis | 13.74 | 9.78 | 41 | 130392 | 8605 | 70789406 |
Mycoplasma test positive | 13.67 | 9.78 | 7 | 130426 | 203 | 70797808 |
Intentional product misuse | 13.61 | 9.78 | 88 | 130345 | 79507 | 70718504 |
Catastrophic reaction | 13.61 | 9.78 | 4 | 130429 | 23 | 70797988 |
Rhinorrhoea | 13.60 | 9.78 | 184 | 130249 | 66187 | 70731824 |
Status epilepticus | 13.59 | 9.78 | 15 | 130418 | 24511 | 70773500 |
Pulmonary alveolar haemorrhage | 13.58 | 9.78 | 46 | 130387 | 10323 | 70787688 |
Delusional disorder, persecutory type | 13.57 | 9.78 | 9 | 130424 | 427 | 70797584 |
Arthritis | 13.56 | 9.78 | 115 | 130318 | 97865 | 70700146 |
Type 2 diabetes mellitus | 13.53 | 9.78 | 39 | 130394 | 44041 | 70753970 |
Asthmatic crisis | 13.51 | 9.78 | 17 | 130416 | 1867 | 70796144 |
Pleural fistula | 13.46 | 9.78 | 4 | 130429 | 24 | 70797987 |
Dyshidrotic eczema | 13.45 | 9.78 | 10 | 130423 | 570 | 70797441 |
Bronchial disorder | 13.43 | 9.78 | 19 | 130414 | 2335 | 70795676 |
End stage renal disease | 13.38 | 9.78 | 48 | 130385 | 11085 | 70786926 |
Herpes zoster | 13.21 | 9.78 | 97 | 130336 | 85138 | 70712873 |
Interleukin level increased | 13.20 | 9.78 | 9 | 130424 | 447 | 70797564 |
Neoplasm progression | 13.18 | 9.78 | 41 | 130392 | 45187 | 70752824 |
Leukaemoid reaction | 13.17 | 9.78 | 8 | 130425 | 325 | 70797686 |
Sinus congestion | 13.12 | 9.78 | 65 | 130368 | 17308 | 70780703 |
Acute sinusitis | 13.11 | 9.78 | 26 | 130407 | 4215 | 70793796 |
Adverse drug reaction | 13.10 | 9.78 | 52 | 130381 | 53292 | 70744719 |
Back pain | 13.09 | 9.78 | 389 | 130044 | 270763 | 70527248 |
Skin ulcer | 13.09 | 9.78 | 45 | 130388 | 48100 | 70749911 |
Sarcoidosis | 13.07 | 9.78 | 34 | 130399 | 6593 | 70791418 |
Febrile bone marrow aplasia | 13.07 | 9.78 | 3 | 130430 | 11988 | 70786023 |
Nocardiosis | 13.01 | 9.78 | 29 | 130404 | 5100 | 70792911 |
Poor feeding infant | 12.99 | 9.78 | 6 | 130427 | 138 | 70797873 |
Dysbiosis | 12.94 | 9.78 | 12 | 130421 | 932 | 70797079 |
Haemorrhoids thrombosed | 12.93 | 9.78 | 7 | 130426 | 228 | 70797783 |
Laryngeal mass | 12.90 | 9.78 | 5 | 130428 | 73 | 70797938 |
Q fever | 12.90 | 9.78 | 7 | 130426 | 229 | 70797782 |
Second primary malignancy | 12.83 | 9.78 | 4 | 130429 | 13047 | 70784964 |
Infusion site streaking | 12.83 | 9.78 | 9 | 130424 | 468 | 70797543 |
Occupational exposure to air contaminants | 12.79 | 9.78 | 6 | 130427 | 143 | 70797868 |
Multiple-drug resistance | 12.77 | 9.78 | 36 | 130397 | 7319 | 70790692 |
Diverticulitis | 12.76 | 9.78 | 37 | 130396 | 41697 | 70756314 |
Renal injury | 12.72 | 9.78 | 61 | 130372 | 16033 | 70781978 |
Miosis | 12.70 | 9.78 | 5 | 130428 | 14096 | 70783915 |
Sinusitis | 12.69 | 9.78 | 404 | 130029 | 168791 | 70629220 |
Humidity intolerance | 12.68 | 9.78 | 8 | 130425 | 348 | 70797663 |
Pneumonia acinetobacter | 12.64 | 9.78 | 6 | 130427 | 147 | 70797864 |
Nasal congestion | 12.62 | 9.78 | 180 | 130253 | 65492 | 70732519 |
Altered state of consciousness | 12.59 | 9.78 | 35 | 130398 | 39987 | 70758024 |
Pulmonary vasculitis | 12.56 | 9.78 | 9 | 130424 | 484 | 70797527 |
Deafness unilateral | 12.56 | 9.78 | 24 | 130409 | 3785 | 70794226 |
Maternal exposure during pregnancy | 12.53 | 9.78 | 289 | 130144 | 115056 | 70682955 |
Lemierre syndrome | 12.49 | 9.78 | 6 | 130427 | 151 | 70797860 |
Chest X-ray abnormal | 12.44 | 9.78 | 35 | 130398 | 7109 | 70790902 |
Haematemesis | 12.35 | 9.78 | 47 | 130386 | 48750 | 70749261 |
Liver function test | 12.31 | 9.78 | 6 | 130427 | 156 | 70797855 |
Eye swelling | 12.31 | 9.78 | 80 | 130353 | 23534 | 70774477 |
Depressed mood | 12.29 | 9.78 | 129 | 130304 | 43691 | 70754320 |
Pain in jaw | 12.21 | 9.78 | 39 | 130394 | 42630 | 70755381 |
Cerebral toxoplasmosis | 12.18 | 9.78 | 17 | 130416 | 2063 | 70795948 |
Head injury | 12.18 | 9.78 | 28 | 130405 | 34113 | 70763898 |
Pneumopericardium | 12.18 | 9.78 | 6 | 130427 | 160 | 70797851 |
Bulimia nervosa | 12.17 | 9.78 | 7 | 130426 | 257 | 70797754 |
Sensory loss | 12.16 | 9.78 | 3 | 130430 | 11416 | 70786595 |
Hepatosplenomegaly | 12.13 | 9.78 | 30 | 130403 | 5640 | 70792371 |
Multiple organ dysfunction syndrome | 12.13 | 9.78 | 273 | 130160 | 108242 | 70689769 |
Normal newborn | 12.10 | 9.78 | 32 | 130401 | 6268 | 70791743 |
Borderline personality disorder | 12.07 | 9.78 | 11 | 130422 | 835 | 70797176 |
Neurological examination abnormal | 12.04 | 9.78 | 9 | 130424 | 517 | 70797494 |
ADAMTS13 activity decreased | 12.04 | 9.78 | 6 | 130427 | 164 | 70797847 |
Inappropriate schedule of product administration | 12.02 | 9.78 | 133 | 130300 | 107422 | 70690589 |
Inguinal hernia repair | 12.00 | 9.78 | 7 | 130426 | 264 | 70797747 |
Localised infection | 11.99 | 9.78 | 27 | 130406 | 33131 | 70764880 |
Muscle rigidity | 11.97 | 9.78 | 10 | 130423 | 18640 | 70779371 |
Lethargy | 11.97 | 9.78 | 85 | 130348 | 75165 | 70722846 |
Palatal oedema | 11.93 | 9.78 | 13 | 130420 | 1225 | 70796786 |
Ruptured ectopic pregnancy | 11.88 | 9.78 | 8 | 130425 | 389 | 70797622 |
Syphilis | 11.88 | 9.78 | 9 | 130424 | 528 | 70797483 |
Infection reactivation | 11.87 | 9.78 | 18 | 130415 | 2355 | 70795656 |
Paraesthesia oral | 11.87 | 9.78 | 58 | 130375 | 15359 | 70782652 |
Ventricular fibrillation | 11.86 | 9.78 | 88 | 130345 | 27023 | 70770988 |
Procedural anxiety | 11.86 | 9.78 | 10 | 130423 | 684 | 70797327 |
Hemianopia heteronymous | 11.80 | 9.78 | 5 | 130428 | 93 | 70797918 |
Hypo HDL cholesterolaemia | 11.76 | 9.78 | 3 | 130430 | 9 | 70798002 |
Diffuse panbronchiolitis | 11.76 | 9.78 | 3 | 130430 | 9 | 70798002 |
Dizziness exertional | 11.74 | 9.78 | 9 | 130424 | 537 | 70797474 |
Rhinovirus infection | 11.73 | 9.78 | 33 | 130400 | 6700 | 70791311 |
Cheilitis | 11.73 | 9.78 | 27 | 130406 | 4850 | 70793161 |
Secretion discharge | 11.69 | 9.78 | 51 | 130382 | 12882 | 70785129 |
Cystic fibrosis hepatic disease | 11.68 | 9.78 | 4 | 130429 | 40 | 70797971 |
Coinfection | 11.68 | 9.78 | 4 | 130429 | 40 | 70797971 |
Deep vein thrombosis | 11.68 | 9.78 | 277 | 130156 | 110765 | 70687246 |
Biopsy colon abnormal | 11.65 | 9.78 | 5 | 130428 | 96 | 70797915 |
Coronavirus test positive | 11.62 | 9.78 | 12 | 130421 | 1063 | 70796948 |
Injection site mass | 11.58 | 9.78 | 10 | 130423 | 18333 | 70779678 |
Skin disorder | 11.57 | 9.78 | 24 | 130409 | 30333 | 70767678 |
Loss of consciousness | 11.56 | 9.78 | 209 | 130224 | 155507 | 70642504 |
Stomatococcal infection | 11.53 | 9.78 | 7 | 130426 | 284 | 70797727 |
Atypical mycobacterium test positive | 11.52 | 9.78 | 3 | 130430 | 10 | 70798001 |
CD4 lymphocytes increased | 11.51 | 9.78 | 7 | 130426 | 285 | 70797726 |
Veillonella infection | 11.51 | 9.78 | 4 | 130429 | 42 | 70797969 |
Plasma cell myeloma | 11.49 | 9.78 | 83 | 130350 | 73118 | 70724893 |
Multiple sclerosis | 11.42 | 9.78 | 18 | 130415 | 25267 | 70772744 |
Haemolytic anaemia | 11.41 | 9.78 | 61 | 130372 | 16733 | 70781278 |
Underdose | 11.39 | 9.78 | 23 | 130410 | 29360 | 70768651 |
Suicidal ideation | 11.37 | 9.78 | 78 | 130355 | 69518 | 70728493 |
Myelosuppression | 11.35 | 9.78 | 24 | 130409 | 30121 | 70767890 |
Anal skin tags | 11.34 | 9.78 | 8 | 130425 | 420 | 70797591 |
Toxic optic neuropathy | 11.33 | 9.78 | 12 | 130421 | 1094 | 70796917 |
Macular degeneration | 11.31 | 9.78 | 35 | 130398 | 7493 | 70790518 |
Foetal death | 11.29 | 9.78 | 31 | 130402 | 6208 | 70791803 |
Vascular parkinsonism | 11.28 | 9.78 | 5 | 130428 | 104 | 70797907 |
Red blood cell sedimentation rate increased | 11.28 | 9.78 | 35 | 130398 | 38607 | 70759404 |
Hypersensitivity | 11.27 | 9.78 | 329 | 130104 | 229483 | 70568528 |
Ill-defined disorder | 11.25 | 9.78 | 57 | 130376 | 54684 | 70743327 |
Urinary incontinence | 11.24 | 9.78 | 34 | 130399 | 37808 | 70760203 |
Virologic failure | 11.18 | 9.78 | 23 | 130410 | 3827 | 70794184 |
Immunosuppressant drug level increased | 11.18 | 9.78 | 36 | 130397 | 7871 | 70790140 |
Bronchospasm | 11.15 | 9.78 | 76 | 130357 | 22716 | 70775295 |
Eosinophilic pleural effusion | 11.11 | 9.78 | 7 | 130426 | 304 | 70797707 |
Neurilemmoma benign | 11.10 | 9.78 | 3 | 130430 | 12 | 70797999 |
Papillary muscle rupture | 11.10 | 9.78 | 3 | 130430 | 12 | 70797999 |
Blood alkaline phosphatase increased | 11.08 | 9.78 | 160 | 130273 | 58361 | 70739650 |
Hip fracture | 11.06 | 9.78 | 22 | 130411 | 28241 | 70769770 |
Disturbance in attention | 11.06 | 9.78 | 41 | 130392 | 42853 | 70755158 |
Eosinophilic pustular folliculitis | 10.99 | 9.78 | 5 | 130428 | 111 | 70797900 |
Acute kidney injury | 10.93 | 9.78 | 1014 | 129419 | 473610 | 70324401 |
Laryngeal pain | 10.90 | 9.78 | 29 | 130404 | 5699 | 70792312 |
Product prescribing error | 10.87 | 9.78 | 36 | 130397 | 38916 | 70759095 |
Presyncope | 10.86 | 9.78 | 34 | 130399 | 37404 | 70760607 |
Rash erythematous | 10.85 | 9.78 | 144 | 130289 | 51574 | 70746437 |
Anxiety | 10.78 | 9.78 | 502 | 129931 | 219828 | 70578183 |
Chest pain | 10.74 | 9.78 | 565 | 129868 | 250695 | 70547316 |
Ectopic pregnancy | 10.73 | 9.78 | 14 | 130419 | 1594 | 70796417 |
Enanthema | 10.71 | 9.78 | 10 | 130423 | 783 | 70797228 |
Gallbladder hypofunction | 10.71 | 9.78 | 8 | 130425 | 459 | 70797552 |
Angina bullosa haemorrhagica | 10.64 | 9.78 | 6 | 130427 | 212 | 70797799 |
Glucose tolerance impaired | 10.56 | 9.78 | 32 | 130401 | 6774 | 70791237 |
Conjunctivochalasis | 10.55 | 9.78 | 3 | 130430 | 15 | 70797996 |
Pneumonia serratia | 10.55 | 9.78 | 3 | 130430 | 15 | 70797996 |
Toothache | 10.52 | 9.78 | 11 | 130422 | 18419 | 70779592 |
Bronchopleural fistula | 10.51 | 9.78 | 9 | 130424 | 629 | 70797382 |
Interleukin-2 receptor increased | 10.51 | 9.78 | 6 | 130427 | 217 | 70797794 |
Haemoglobin decreased | 10.49 | 9.78 | 292 | 130141 | 204867 | 70593144 |
Nail pitting | 10.48 | 9.78 | 7 | 130426 | 336 | 70797675 |
Bone density decreased | 10.45 | 9.78 | 4 | 130429 | 11470 | 70786541 |
Ischaemic stroke | 10.42 | 9.78 | 26 | 130407 | 30794 | 70767217 |
Ureteric perforation | 10.39 | 9.78 | 3 | 130430 | 16 | 70797995 |
Graft infection | 10.37 | 9.78 | 9 | 130424 | 641 | 70797370 |
Linear IgA disease | 10.36 | 9.78 | 19 | 130414 | 2905 | 70795106 |
Hypoaesthesia | 10.30 | 9.78 | 210 | 130223 | 153529 | 70644482 |
Hepatocellular carcinoma | 10.27 | 9.78 | 3 | 130430 | 10205 | 70787806 |
Glucose-6-phosphate dehydrogenase deficiency | 10.26 | 9.78 | 7 | 130426 | 348 | 70797663 |
Wrong technique in product usage process | 10.25 | 9.78 | 79 | 130354 | 68619 | 70729392 |
Loss of personal independence in daily activities | 10.25 | 9.78 | 216 | 130217 | 84694 | 70713317 |
Nodule | 10.22 | 9.78 | 13 | 130420 | 19956 | 70778055 |
Mediastinal shift | 10.22 | 9.78 | 4 | 130429 | 60 | 70797951 |
Drug screen false positive | 10.22 | 9.78 | 11 | 130422 | 1022 | 70796989 |
Anticoagulation drug level above therapeutic | 10.19 | 9.78 | 20 | 130413 | 3218 | 70794793 |
Interstitial granulomatous dermatitis | 10.17 | 9.78 | 6 | 130427 | 231 | 70797780 |
Bronchiolitis | 10.16 | 9.78 | 22 | 130411 | 3792 | 70794219 |
Rotavirus infection | 10.15 | 9.78 | 9 | 130424 | 659 | 70797352 |
Epidermolysis | 10.14 | 9.78 | 8 | 130425 | 498 | 70797513 |
Autoimmune hepatitis | 10.11 | 9.78 | 43 | 130390 | 10743 | 70787268 |
Vaginal abscess | 10.08 | 9.78 | 7 | 130426 | 358 | 70797653 |
Benign prostatic hyperplasia | 10.07 | 9.78 | 42 | 130391 | 10401 | 70787610 |
Akathisia | 10.06 | 9.78 | 5 | 130428 | 12288 | 70785723 |
Dry mouth | 10.06 | 9.78 | 82 | 130351 | 70375 | 70727636 |
Superinfection bacterial | 10.02 | 9.78 | 12 | 130421 | 1252 | 70796759 |
Cytokine release syndrome | 10.02 | 9.78 | 21 | 130412 | 26446 | 70771565 |
Opportunistic infection | 9.98 | 9.78 | 18 | 130415 | 2718 | 70795293 |
Abortion spontaneous | 9.96 | 9.78 | 83 | 130350 | 26396 | 70771615 |
Legionella test positive | 9.96 | 9.78 | 3 | 130430 | 19 | 70797992 |
Tooth discolouration | 9.93 | 9.78 | 11 | 130422 | 1056 | 70796955 |
Transfusion | 9.92 | 9.78 | 12 | 130421 | 18824 | 70779187 |
Squamous cell carcinoma of skin | 9.91 | 9.78 | 48 | 130385 | 12664 | 70785347 |
Kidney transplant rejection | 9.89 | 9.78 | 3 | 130430 | 9958 | 70788053 |
Prescribed underdose | 9.87 | 9.78 | 15 | 130418 | 21370 | 70776641 |
Sinus operation | 9.84 | 9.78 | 15 | 130418 | 1972 | 70796039 |
Atrial conduction time prolongation | 9.83 | 9.78 | 3 | 130430 | 20 | 70797991 |
None
Source | Code | Description |
---|---|---|
ATC | J01FA10 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS Macrolides |
ATC | J01RA07 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
ATC | S01AA26 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
FDA CS | M0028311 | Macrolides |
FDA Chemical/Ingredient | N0000007529 | Macrolides |
FDA EPC | N0000175935 | Macrolide Antimicrobial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Acute gonococcal urethritis | indication | 29864006 | |
Bacterial blepharitis | indication | 41446000 | DOID:9423 |
Streptococcal tonsillitis | indication | 41582007 | |
Pneumonia due to Mycoplasma pneumoniae | indication | 46970008 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Acute bacterial sinusitis | indication | 75498004 | |
Dacryocystitis | indication | 85777005 | DOID:9938 |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Urethritis due to Chlamydia trachomatis | indication | 179101003 | |
Pulmonary Mycobacterium avium complex infection | indication | 186342000 | |
Chlamydial pelvic inflammatory disease | indication | 188463006 | |
Acute bacterial bronchitis | indication | 233598009 | |
Pneumococcal pneumonia | indication | 233607000 | |
Chlamydial pneumonia | indication | 233609002 | |
Chancroid | indication | 266143009 | DOID:13778 |
Pelvic inflammatory disease due to Mycoplasma hominis | indication | 270550006 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Infective otitis media | indication | 312218008 | |
Bacterial hordeolum | indication | 397513003 | DOID:9909 |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Acute exacerbation of chronic bronchitis | indication | 425748003 | |
Pneumonia due to Staphylococcus aureus | indication | 441658007 | |
Haemophilus Influenzae Acute Otitis Media | indication | ||
Pneumococcal Acute Otitis Media | indication | ||
Skin and Skin Structure Streptococcus Agalactiae Infection | indication | ||
Pelvic Inflammatory Disease with Neisseria Gonorrhea | indication | ||
Legionella Pneumophila Pneumonia | indication | ||
Moraxella Catarrhalis Pneumonia | indication | ||
Chlamydia Cervicitis | indication | ||
Moraxella Catarrhalis Acute Otitis Media | indication | ||
Pyrexia of unknown origin | off-label use | 7520000 | |
Traveler's diarrhea | off-label use | 11840006 | |
Enteric campylobacteriosis | off-label use | 18081009 | |
Pertussis | off-label use | 27836007 | |
Gonorrhea of rectum | off-label use | 42746002 | |
Gonorrhea of pharynx | off-label use | 74372003 | |
Coronavirus infection | off-label use | 186747009 | |
Boutonneuse fever | off-label use | 186774005 | DOID:14095 |
Toxoplasmosis associated with acquired immunodeficiency syndrome | off-label use | 421666009 | |
Prevention of Bacterial Endocarditis | off-label use | ||
Sexual Transmitted Disease Exposure from Sexual Assault | off-label use | ||
Inflammatory Disease of Female Pelvic Organs | off-label use | ||
Jaundice | contraindication | 18165001 | |
Torsades de pointes | contraindication | 31722008 | |
Chronic heart failure | contraindication | 48447003 | |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Prolonged QT interval | contraindication | 111975006 | |
Hearing disorder | contraindication | 128540005 | |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Congenital long QT syndrome | contraindication | 442917000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.45 | acidic |
pKa2 | 8.87 | Basic |
pKa3 | 8.24 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 2GM BASE/BOT | ZMAX | PF PRISM CV | N050797 | June 10, 2005 | DISCN | FOR SUSPENSION, EXTENDED RELEASE | ORAL | 6984403 | Feb. 14, 2024 | METHOD OF TREATING BACTERIAL INFECTIONS |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 3.39 | WOMBAT-PK | |||||
Multidrug resistance protein 1 | Transporter | IC50 | 3.70 | WOMBAT-PK | |||||
Canalicular multispecific organic anion transporter 1 | Transporter | IC50 | 4.16 | WOMBAT-PK | |||||
Motilin receptor | GPCR | AGONIST | EC50 | 5.50 | IUPHAR |
ID | Source |
---|---|
4020019 | VUID |
N0000148074 | NUI |
D02134 | KEGG_DRUG |
121470-24-4 | SECONDARY_CAS_RN |
117772-70-0 | SECONDARY_CAS_RN |
1298839 | RXNORM |
4020019 | VANDF |
4020964 | VANDF |
C0052796 | UMLSCUI |
ZIT | PDB_CHEM_ID |
CHEMBL529 | ChEMBL_ID |
CHEMBL1200502 | ChEMBL_ID |
D017963 | MESH_DESCRIPTOR_UI |
DB00207 | DRUGBANK_ID |
6510 | IUPHAR_LIGAND_ID |
447043 | PUBCHEM_CID |
4238 | MMSL |
72442 | MMSL |
d00091 | MMSL |
003635 | NDDF |
387531004 | SNOMEDCT_US |
391805000 | SNOMEDCT_US |
734459003 | SNOMEDCT_US |
785687007 | SNOMEDCT_US |
96034006 | SNOMEDCT_US |
6197 | INN_ID |
JTE4MNN1MD | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0400 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | NDA | 29 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0400 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | NDA | 29 sections |
ZITHROMAX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3051 | POWDER, FOR SUSPENSION | 1 g | ORAL | NDA | 31 sections |
ZITHROMAX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3051 | POWDER, FOR SUSPENSION | 1 g | ORAL | NDA | 31 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3060 | TABLET, FILM COATED | 250 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3060 | TABLET, FILM COATED | 250 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3060 | TABLET, FILM COATED | 250 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3070 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3070 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3070 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 30 sections |
ZITHROMAX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3080 | TABLET, FILM COATED | 600 mg | ORAL | NDA | 31 sections |
ZITHROMAX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3080 | TABLET, FILM COATED | 600 mg | ORAL | NDA | 31 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3110 | POWDER, FOR SUSPENSION | 100 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3110 | POWDER, FOR SUSPENSION | 100 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3110 | POWDER, FOR SUSPENSION | 100 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3120 | POWDER, FOR SUSPENSION | 200 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3120 | POWDER, FOR SUSPENSION | 200 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3120 | POWDER, FOR SUSPENSION | 200 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3130 | POWDER, FOR SUSPENSION | 200 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3130 | POWDER, FOR SUSPENSION | 200 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3130 | POWDER, FOR SUSPENSION | 200 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3140 | POWDER, FOR SUSPENSION | 200 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3140 | POWDER, FOR SUSPENSION | 200 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3140 | POWDER, FOR SUSPENSION | 200 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3150 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | NDA | 29 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-3150 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | NDA | 29 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4061 | TABLET, FILM COATED | 250 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4061 | TABLET, FILM COATED | 250 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4061 | TABLET, FILM COATED | 250 mg | ORAL | NDA | 30 sections |
Zithromax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-9500 | TABLET, FILM COATED | 250 mg | ORAL | UNAPPROVED DRUG FOR USE IN DRUG SHORTAGE | 32 sections |