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natamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, produced by Streptomyces strains | 1885 | 7681-93-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 20 | mg | O |
| 0.30 | g | O |
| 25 | mg | V |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1 | 19 | |||
| kinase-selectivity-class | GRK2,MAP2K6 | 2 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 30, 1978 | FDA | ALCON |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Persistent genital arousal disorder | 204.07 | 110.28 | 25 | 327 | 675 | 90627420 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Persistent genital arousal disorder | 154.03 | 79.25 | 23 | 1698 | 653 | 110586925 |
| Appendicolith | 117.69 | 79.25 | 30 | 1691 | 14225 | 110573353 |
| Appendicitis | 97.16 | 79.25 | 30 | 1691 | 28434 | 110559144 |
| Blood phosphorus increased | 94.76 | 79.25 | 26 | 1695 | 16314 | 110571264 |
| Myasthenia gravis | 92.08 | 79.25 | 27 | 1694 | 21484 | 110566094 |
| Ventricular fibrillation | 82.34 | 79.25 | 29 | 1692 | 41284 | 110546294 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A01AB10 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment |
| ATC | A07AA03 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Antibiotics |
| ATC | D01AA02 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Antibiotics |
| ATC | G01AA02 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Antibiotics |
| ATC | S01AA10 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
| FDA CS | M0017172 | Polyenes |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000891 | Anti-Infective Agents, Local |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000935 | Antifungal Agents |
| FDA EPC | N0000175936 | Polyene Antimicrobial |
| CHEBI has role | CHEBI:65256 | antimicrobial food preservative |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:68495 | apoptosis inducer |
| CHEBI has role | CHEBI:76969 | bacterial metabolite |
| CHEBI has role | CHEBI:86328 | antifungal agrochemical |
Related Drugs by ATC class:
A01AB Antiinfectives and antiseptics for local oral treatment 22 drugs
A07AA Antibiotics 12 drugs
D01AA Antibiotics 6 drugs
G01AA Antibiotics 10 drugs
S01AA Antibiotics 27 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Fungal conjunctivitis | indication | 231862003 | |
| Fungal keratitis | indication | 314558005 | |
| Fungal Blepharitis | indication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.46 | acidic |
| pKa2 | 9.99 | acidic |
| pKa3 | 10.71 | acidic |
| pKa4 | 12.54 | acidic |
| pKa5 | 13.88 | acidic |
| pKa6 | 8.62 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018597 | VUID |
| N0000146913 | NUI |
| D00884 | KEGG_DRUG |
| 4018597 | VANDF |
| C0027444 | UMLSCUI |
| CHEBI:7488 | CHEBI |
| CHEMBL1200656 | ChEMBL_ID |
| D010866 | MESH_DESCRIPTOR_UI |
| DB00826 | DRUGBANK_ID |
| 868 | INN_ID |
| 8O0C852CPO | UNII |
| 5284447 | PUBCHEM_CID |
| 202745 | RXNORM |
| 5158 | MMSL |
| d01213 | MMSL |
| 002891 | NDDF |
| 34462007 | SNOMEDCT_US |
| 372712006 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| NATACYN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71776-005 | SUSPENSION/ DROPS | 50 mg | OPHTHALMIC | NDA | 15 sections |
| NATACYN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71776-005 | SUSPENSION/ DROPS | 50 mg | OPHTHALMIC | NDA | 15 sections |
| NATACYN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 82667-012 | SUSPENSION/ DROPS | 50 mg | OPHTHALMIC | NDA | 16 sections |
| NATACYN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 82667-012 | SUSPENSION/ DROPS | 50 mg | OPHTHALMIC | NDA | 16 sections |