natamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 1885 7681-93-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pimaricin
  • tennecetin
  • natamycin
  • myuprozine
  • pimafucin
Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically.
  • Molecular weight: 665.73
  • Formula: C33H47NO13
  • CLOGP: -4.75
  • LIPINSKI: 3
  • HAC: 14
  • HDO: 7
  • TPSA: 230.99
  • ALOGS: -3.38
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
0.30 g O
25 mg V

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 30, 1978 FDA ALCON

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AB10 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Antiinfectives and antiseptics for local oral treatment
ATC A07AA03 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC D01AA02 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Antibiotics
ATC G01AA02 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Antibiotics
ATC S01AA10 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
FDA CS M0017172 Polyenes
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D000935 Antifungal Agents
CHEBI has role CHEBI:65256 antimicrobial food preservatives
CHEBI has role CHEBI:66981 ophthalmology drugs
CHEBI has role CHEBI:68495 Type I cell-death inducers
CHEBI has role CHEBI:86328 anti-fungal agrichemical
FDA EPC N0000175936 Polyene Antimicrobial

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Fungal conjunctivitis indication 231862003
Fungal keratitis indication 314558005
Fungal Blepharitis indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.46 acidic
pKa2 9.99 acidic
pKa3 10.71 acidic
pKa4 12.54 acidic
pKa5 13.88 acidic
pKa6 8.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018597 VUID
N0000146913 NUI
D00884 KEGG_DRUG
4018597 VANDF
C0027444 UMLSCUI
CHEBI:7488 CHEBI
CHEMBL1200656 ChEMBL_ID
D010866 MESH_DESCRIPTOR_UI
DB00826 DRUGBANK_ID
868 INN_ID
8O0C852CPO UNII
5284447 PUBCHEM_CID
202745 RXNORM
5158 MMSL
d01213 MMSL
002891 NDDF
34462007 SNOMEDCT_US
372712006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NATACYN HUMAN PRESCRIPTION DRUG LABEL 1 0065-0645 SUSPENSION/ DROPS 50 mg OPHTHALMIC NDA 15 sections
NATACYN HUMAN PRESCRIPTION DRUG LABEL 1 71776-005 SUSPENSION/ DROPS 50 mg OPHTHALMIC NDA 15 sections