Stem definition | Drug id | CAS RN |
---|---|---|
antibacterials, nalidixic acid derivatives | 659 | 85721-33-1 |
Dose | Unit | Route |
---|---|---|
1 | g | O |
0.80 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.15 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 65 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 34.49 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 8.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.70 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 3.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 22, 1987 | FDA | BAYER HLTHCARE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 1290.66 | 9.34 | 2130 | 110480 | 248880 | 50243634 |
Tendon pain | 621.18 | 9.34 | 238 | 112372 | 2740 | 50489774 |
Tendonitis | 529.43 | 9.34 | 375 | 112235 | 16330 | 50476184 |
Abortion spontaneous | 423.19 | 9.34 | 493 | 112117 | 41279 | 50451235 |
Drug reaction with eosinophilia and systemic symptoms | 333.17 | 9.34 | 362 | 112248 | 28062 | 50464452 |
Tendon rupture | 275.27 | 9.34 | 181 | 112429 | 6963 | 50485551 |
Tendon disorder | 245.31 | 9.34 | 151 | 112459 | 5171 | 50487343 |
Drug interaction | 243.31 | 9.34 | 983 | 111627 | 198638 | 50293876 |
Pemphigus | 242.81 | 9.34 | 5 | 112605 | 120161 | 50372353 |
Toxic epidermal necrolysis | 224.70 | 9.34 | 255 | 112355 | 20737 | 50471777 |
Tubulointerstitial nephritis | 212.78 | 9.34 | 213 | 112397 | 14998 | 50477516 |
Pathogen resistance | 204.39 | 9.34 | 138 | 112472 | 5551 | 50486963 |
Hand deformity | 203.10 | 9.34 | 4 | 112606 | 100195 | 50392319 |
Glossodynia | 188.92 | 9.34 | 19 | 112591 | 115550 | 50376964 |
Drug ineffective | 188.79 | 9.34 | 1064 | 111546 | 818269 | 49674245 |
Rheumatoid arthritis | 186.10 | 9.34 | 110 | 112500 | 202440 | 50290074 |
Synovitis | 168.66 | 9.34 | 35 | 112575 | 123830 | 50368684 |
Acute kidney injury | 154 | 9.34 | 950 | 111660 | 227108 | 50265406 |
Systemic lupus erythematosus | 146.04 | 9.34 | 65 | 112545 | 140557 | 50351957 |
Therapeutic product effect decreased | 141.11 | 9.34 | 63 | 112547 | 135987 | 50356527 |
Clostridium difficile colitis | 140.32 | 9.34 | 185 | 112425 | 17557 | 50474957 |
Anti-cyclic citrullinated peptide antibody positive | 138.50 | 9.34 | 4 | 112606 | 70583 | 50421931 |
Contraindicated product administered | 138.03 | 9.34 | 80 | 112530 | 148878 | 50343636 |
Clostridium difficile infection | 132.66 | 9.34 | 218 | 112392 | 25221 | 50467293 |
Arthropathy | 127.26 | 9.34 | 99 | 112511 | 157807 | 50334707 |
Pericarditis | 125.85 | 9.34 | 14 | 112596 | 78675 | 50413839 |
Stevens-Johnson syndrome | 123.82 | 9.34 | 194 | 112416 | 21558 | 50470956 |
Alopecia | 110.40 | 9.34 | 238 | 112372 | 244809 | 50247705 |
Tinnitus | 109.30 | 9.34 | 212 | 112398 | 27920 | 50464594 |
Drug intolerance | 107.94 | 9.34 | 202 | 112408 | 218902 | 50273612 |
Infusion related reaction | 104.85 | 9.34 | 134 | 112476 | 169423 | 50323091 |
Wound | 103.54 | 9.34 | 53 | 112557 | 105741 | 50386773 |
Dysbiosis | 100.32 | 9.34 | 42 | 112568 | 618 | 50491896 |
Completed suicide | 97.29 | 9.34 | 90 | 112520 | 131799 | 50360715 |
Myalgia | 95.46 | 9.34 | 536 | 112074 | 123783 | 50368731 |
Rheumatoid factor positive | 93.71 | 9.34 | 4 | 112606 | 49855 | 50442659 |
Joint swelling | 92.63 | 9.34 | 261 | 112349 | 245025 | 50247489 |
Duodenal ulcer perforation | 87.98 | 9.34 | 3 | 112607 | 45608 | 50446906 |
Death | 86.57 | 9.34 | 401 | 112209 | 324978 | 50167536 |
Cholecystitis chronic | 82.99 | 9.34 | 105 | 112505 | 9564 | 50482950 |
Paraesthesia | 82.95 | 9.34 | 504 | 112106 | 119739 | 50372775 |
Fall | 79.80 | 9.34 | 429 | 112181 | 334503 | 50158011 |
Helicobacter infection | 79.07 | 9.34 | 9 | 112601 | 49693 | 50442821 |
Early retirement | 78.20 | 9.34 | 16 | 112594 | 4 | 50492510 |
Tendon discomfort | 78.17 | 9.34 | 24 | 112586 | 131 | 50492383 |
Hepatic enzyme increased | 74.59 | 9.34 | 119 | 112491 | 137261 | 50355253 |
Panic attack | 74.20 | 9.34 | 145 | 112465 | 19197 | 50473317 |
Anxiety | 72.44 | 9.34 | 657 | 111953 | 176949 | 50315565 |
Rash maculo-papular | 71.62 | 9.34 | 173 | 112437 | 26468 | 50466046 |
Drug resistance | 71.21 | 9.34 | 141 | 112469 | 18848 | 50473666 |
Injection site pain | 70.42 | 9.34 | 86 | 112524 | 110938 | 50381576 |
Disturbance in attention | 69.82 | 9.34 | 189 | 112421 | 30997 | 50461517 |
Tendon injury | 68.54 | 9.34 | 44 | 112566 | 1623 | 50490891 |
Multiple organ dysfunction syndrome | 68.54 | 9.34 | 257 | 112353 | 50080 | 50442434 |
Treatment failure | 68.51 | 9.34 | 126 | 112484 | 137511 | 50355003 |
Dermatitis exfoliative | 68.24 | 9.34 | 70 | 112540 | 5072 | 50487442 |
Abdominal pain | 66.68 | 9.34 | 811 | 111799 | 235417 | 50257097 |
Therapeutic product effect incomplete | 65.65 | 9.34 | 64 | 112546 | 91451 | 50401063 |
Geotrichum infection | 65.10 | 9.34 | 28 | 112582 | 442 | 50492072 |
Discomfort | 64.56 | 9.34 | 88 | 112522 | 108292 | 50384222 |
Joint noise | 63.05 | 9.34 | 57 | 112553 | 3530 | 50488984 |
Musculoskeletal injury | 61.69 | 9.34 | 19 | 112591 | 105 | 50492409 |
Muscle injury | 60.88 | 9.34 | 6 | 112604 | 37105 | 50455409 |
Nasopharyngitis | 60.44 | 9.34 | 223 | 112387 | 192704 | 50299810 |
Neuropathy peripheral | 60.14 | 9.34 | 395 | 112215 | 96362 | 50396152 |
Skin candida | 59.52 | 9.34 | 37 | 112573 | 1289 | 50491225 |
Fistula | 59.35 | 9.34 | 82 | 112528 | 8136 | 50484378 |
Intentional overdose | 58.66 | 9.34 | 33 | 112577 | 62471 | 50430043 |
Febrile neutropenia | 57.87 | 9.34 | 394 | 112216 | 97273 | 50395241 |
Folliculitis | 55.65 | 9.34 | 10 | 112600 | 39215 | 50453299 |
Weight increased | 55.29 | 9.34 | 246 | 112364 | 201645 | 50290869 |
Renal tubular necrosis | 52.82 | 9.34 | 87 | 112523 | 10081 | 50482433 |
Pseudomembranous colitis | 52.41 | 9.34 | 46 | 112564 | 2739 | 50489775 |
Burning sensation | 51.41 | 9.34 | 219 | 112391 | 45227 | 50447287 |
Pyrexia | 51.00 | 9.34 | 1155 | 111455 | 379048 | 50113466 |
Product use issue | 50.68 | 9.34 | 167 | 112443 | 149308 | 50343206 |
Injection site erythema | 49.70 | 9.34 | 56 | 112554 | 74880 | 50417634 |
Connective tissue disorder | 49.41 | 9.34 | 31 | 112579 | 1098 | 50491416 |
Peripheral swelling | 49.39 | 9.34 | 263 | 112347 | 205673 | 50286841 |
Swelling | 48.47 | 9.34 | 256 | 112354 | 200616 | 50291898 |
Psoriatic arthropathy | 48.38 | 9.34 | 22 | 112588 | 47010 | 50445504 |
Trimethylaminuria | 47.56 | 9.34 | 16 | 112594 | 122 | 50492392 |
Torsade de pointes | 46.95 | 9.34 | 90 | 112520 | 11745 | 50480769 |
Urinary tract infection | 45.67 | 9.34 | 726 | 111884 | 223294 | 50269220 |
Anal abscess | 45.65 | 9.34 | 49 | 112561 | 3742 | 50488772 |
Thrombocytopenia | 45.43 | 9.34 | 459 | 112151 | 127214 | 50365300 |
Food intolerance | 45.26 | 9.34 | 40 | 112570 | 2404 | 50490110 |
Abdominal discomfort | 45.01 | 9.34 | 316 | 112294 | 231325 | 50261189 |
Impaired work ability | 44.91 | 9.34 | 96 | 112514 | 13544 | 50478970 |
Loss of employment | 44.30 | 9.34 | 33 | 112577 | 1553 | 50490961 |
Pseudomonas infection | 44.10 | 9.34 | 77 | 112533 | 9353 | 50483161 |
Device expulsion | 43.94 | 9.34 | 6 | 112604 | 28816 | 50463698 |
Injury | 43.69 | 9.34 | 220 | 112390 | 48705 | 50443809 |
Diarrhoea | 43.51 | 9.34 | 1659 | 110951 | 586817 | 49905697 |
Emotional distress | 42.95 | 9.34 | 151 | 112459 | 28512 | 50464002 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 42.83 | 9.34 | 21 | 112589 | 454 | 50492060 |
Hip arthroplasty | 42.64 | 9.34 | 8 | 112602 | 30421 | 50462093 |
Total lung capacity increased | 42.35 | 9.34 | 24 | 112586 | 703 | 50491811 |
Maternal exposure during pregnancy | 42.34 | 9.34 | 197 | 112413 | 159581 | 50332933 |
Colitis | 42.29 | 9.34 | 184 | 112426 | 38345 | 50454169 |
Infective pulmonary exacerbation of cystic fibrosis | 41.52 | 9.34 | 68 | 112542 | 7841 | 50484673 |
Muscle atrophy | 41.12 | 9.34 | 59 | 112551 | 6062 | 50486452 |
Injection site reaction | 40.73 | 9.34 | 31 | 112579 | 50001 | 50442513 |
Drug abuse | 40.48 | 9.34 | 44 | 112566 | 59802 | 50432712 |
Hallucination | 40.40 | 9.34 | 208 | 112402 | 46449 | 50446065 |
Product dose omission issue | 40.17 | 9.34 | 242 | 112368 | 183596 | 50308918 |
Therapeutic response decreased | 40.09 | 9.34 | 28 | 112582 | 47203 | 50445311 |
Nervous system disorder | 40.06 | 9.34 | 102 | 112508 | 16121 | 50476393 |
Diverticulitis | 39.95 | 9.34 | 163 | 112447 | 33019 | 50459495 |
Segmental diverticular colitis | 39.69 | 9.34 | 14 | 112596 | 125 | 50492389 |
Anal fistula | 39.45 | 9.34 | 39 | 112571 | 2703 | 50489811 |
Acute generalised exanthematous pustulosis | 39.25 | 9.34 | 71 | 112539 | 8867 | 50483647 |
Pedal pulse abnormal | 38.92 | 9.34 | 14 | 112596 | 133 | 50492381 |
Osteoporosis | 38.90 | 9.34 | 26 | 112584 | 44853 | 50447661 |
Female genital tract fistula | 38.31 | 9.34 | 44 | 112566 | 3622 | 50488892 |
Injection site swelling | 37.86 | 9.34 | 23 | 112587 | 41750 | 50450764 |
Chronic kidney disease | 37.76 | 9.34 | 182 | 112428 | 39589 | 50452925 |
Aspergillus infection | 37.66 | 9.34 | 60 | 112550 | 6761 | 50485753 |
Nephritis allergic | 37.59 | 9.34 | 14 | 112596 | 148 | 50492366 |
Off label use | 37.57 | 9.34 | 788 | 111822 | 473638 | 50018876 |
Neutropenia | 37.44 | 9.34 | 498 | 112112 | 147467 | 50345047 |
Pulmonary eosinophilia | 37.29 | 9.34 | 15 | 112595 | 198 | 50492316 |
Pouchitis | 35.82 | 9.34 | 18 | 112592 | 411 | 50492103 |
Sinusitis | 34.94 | 9.34 | 229 | 112381 | 170329 | 50322185 |
Ectropion | 34.37 | 9.34 | 13 | 112597 | 144 | 50492370 |
Factor V deficiency | 34.27 | 9.34 | 11 | 112599 | 71 | 50492443 |
Muscle twitching | 34.01 | 9.34 | 93 | 112517 | 15338 | 50477176 |
Pyelonephritis | 33.70 | 9.34 | 91 | 112519 | 14898 | 50477616 |
Mitochondrial cytopathy | 32.55 | 9.34 | 14 | 112596 | 221 | 50492293 |
Suicide attempt | 31.81 | 9.34 | 41 | 112569 | 51691 | 50440823 |
Muscular weakness | 31.61 | 9.34 | 337 | 112273 | 94676 | 50397838 |
Klebsiella infection | 31.40 | 9.34 | 57 | 112553 | 7137 | 50485377 |
Toxicity to various agents | 31.25 | 9.34 | 312 | 112298 | 212187 | 50280327 |
Wrong technique in product usage process | 31.14 | 9.34 | 47 | 112563 | 55463 | 50437051 |
Procedural anxiety | 31.11 | 9.34 | 19 | 112591 | 641 | 50491873 |
Vulvovaginal burning sensation | 31.05 | 9.34 | 27 | 112583 | 1588 | 50490926 |
Ill-defined disorder | 30.92 | 9.34 | 46 | 112564 | 54608 | 50437906 |
Muscle contractions involuntary | 30.79 | 9.34 | 29 | 112581 | 1893 | 50490621 |
Malignant neoplasm progression | 30.74 | 9.34 | 66 | 112544 | 68058 | 50424456 |
Calcium ionised decreased | 30.73 | 9.34 | 14 | 112596 | 255 | 50492259 |
Mucosal inflammation | 30.71 | 9.34 | 173 | 112437 | 39969 | 50452545 |
Gastroenteritis pseudomonas | 30.66 | 9.34 | 6 | 112604 | 0 | 50492514 |
Abnormal palmar/plantar creases | 30.65 | 9.34 | 9 | 112601 | 41 | 50492473 |
Intentional product use issue | 30.35 | 9.34 | 80 | 112530 | 76838 | 50415676 |
Psoriasis | 30.19 | 9.34 | 68 | 112542 | 68932 | 50423582 |
Injection site bruising | 29.65 | 9.34 | 23 | 112587 | 36745 | 50455769 |
Factor V inhibition | 29.46 | 9.34 | 12 | 112598 | 164 | 50492350 |
Fat tissue decreased | 29.18 | 9.34 | 7 | 112603 | 11 | 50492503 |
Anorectal ulcer | 29.18 | 9.34 | 9 | 112601 | 50 | 50492464 |
Cystitis | 28.94 | 9.34 | 184 | 112426 | 44380 | 50448134 |
Mineral deficiency | 28.81 | 9.34 | 7 | 112603 | 12 | 50492502 |
Impaired healing | 28.76 | 9.34 | 71 | 112539 | 69715 | 50422799 |
Non-consummation | 28.74 | 9.34 | 9 | 112601 | 53 | 50492461 |
Pregnancy | 28.65 | 9.34 | 15 | 112595 | 29562 | 50462952 |
Oliguria | 28.41 | 9.34 | 59 | 112551 | 8157 | 50484357 |
Coma | 28.34 | 9.34 | 52 | 112558 | 56827 | 50435687 |
Linear IgA disease | 28.31 | 9.34 | 23 | 112587 | 1231 | 50491283 |
Oesophageal spasm | 28.22 | 9.34 | 30 | 112580 | 2266 | 50490248 |
Weight bearing difficulty | 28.13 | 9.34 | 30 | 112580 | 2274 | 50490240 |
Flank pain | 27.88 | 9.34 | 78 | 112532 | 13037 | 50479477 |
Megacolon | 27.82 | 9.34 | 26 | 112584 | 1680 | 50490834 |
Fungaemia | 27.81 | 9.34 | 28 | 112582 | 1984 | 50490530 |
Moraxella test positive | 27.79 | 9.34 | 7 | 112603 | 15 | 50492499 |
Nerve injury | 27.76 | 9.34 | 59 | 112551 | 8291 | 50484223 |
Abscess | 27.55 | 9.34 | 82 | 112528 | 14190 | 50478324 |
Potentiating drug interaction | 27.44 | 9.34 | 38 | 112572 | 3778 | 50488736 |
Biliary dyskinesia | 27.32 | 9.34 | 31 | 112579 | 2519 | 50489995 |
Bacterial colitis | 27.30 | 9.34 | 9 | 112601 | 64 | 50492450 |
Injection site pruritus | 27.01 | 9.34 | 30 | 112580 | 40381 | 50452133 |
Pancytopenia | 27.00 | 9.34 | 296 | 112314 | 83734 | 50408780 |
Knee arthroplasty | 26.96 | 9.34 | 24 | 112586 | 35822 | 50456692 |
Fatigue | 26.79 | 9.34 | 1295 | 111315 | 706306 | 49786208 |
Acute hepatic failure | 26.49 | 9.34 | 86 | 112524 | 15591 | 50476923 |
Bladder pain | 26.45 | 9.34 | 25 | 112585 | 1639 | 50490875 |
Sepsis | 26.37 | 9.34 | 429 | 112181 | 132496 | 50360018 |
Acinetobacter infection | 25.72 | 9.34 | 23 | 112587 | 1404 | 50491110 |
Photosensitivity reaction | 25.71 | 9.34 | 75 | 112535 | 12836 | 50479678 |
Candida infection | 25.55 | 9.34 | 112 | 112498 | 23411 | 50469103 |
Stomatitis | 25.07 | 9.34 | 128 | 112482 | 101216 | 50391298 |
Frequent bowel movements | 25.03 | 9.34 | 78 | 112532 | 13840 | 50478674 |
Accidental exposure to product | 24.96 | 9.34 | 10 | 112600 | 23047 | 50469467 |
Drug-induced liver injury | 24.84 | 9.34 | 126 | 112484 | 27969 | 50464545 |
Hyperacusis | 24.74 | 9.34 | 25 | 112585 | 1779 | 50490735 |
Cardio-respiratory arrest | 24.49 | 9.34 | 52 | 112558 | 53840 | 50438674 |
Cystic fibrosis | 24.41 | 9.34 | 31 | 112579 | 2833 | 50489681 |
Idiopathic intracranial hypertension | 24.22 | 9.34 | 28 | 112582 | 2321 | 50490193 |
Dermatitis bullous | 24.21 | 9.34 | 51 | 112559 | 7122 | 50485392 |
Rectal tube insertion | 24.10 | 9.34 | 6 | 112604 | 12 | 50492502 |
Pain | 23.99 | 9.34 | 1049 | 111561 | 577854 | 49914660 |
Clostridium test positive | 23.59 | 9.34 | 26 | 112584 | 2046 | 50490468 |
Condition aggravated | 23.57 | 9.34 | 493 | 112117 | 296565 | 50195949 |
Septic shock | 23.51 | 9.34 | 212 | 112398 | 56963 | 50435551 |
Multiple sclerosis relapse | 23.50 | 9.34 | 37 | 112573 | 42927 | 50449587 |
Breast cancer | 23.40 | 9.34 | 37 | 112573 | 42853 | 50449661 |
Hypercreatininaemia | 23.34 | 9.34 | 13 | 112597 | 368 | 50492146 |
Phlebitis | 23.31 | 9.34 | 44 | 112566 | 5676 | 50486838 |
Gastroenteritis staphylococcal | 22.92 | 9.34 | 8 | 112602 | 69 | 50492445 |
Chemical burns of eye | 22.72 | 9.34 | 8 | 112602 | 71 | 50492443 |
Diabetes mellitus | 22.54 | 9.34 | 47 | 112563 | 48986 | 50443528 |
Osteochondrosis | 22.48 | 9.34 | 19 | 112591 | 1075 | 50491439 |
Hypoaesthesia | 22.44 | 9.34 | 403 | 112207 | 126854 | 50365660 |
Hepatitis cholestatic | 22.42 | 9.34 | 45 | 112565 | 6072 | 50486442 |
Fixed eruption | 22.42 | 9.34 | 17 | 112593 | 822 | 50491692 |
Basal cell carcinoma | 22.39 | 9.34 | 12 | 112598 | 23344 | 50469170 |
Renal injury | 22.16 | 9.34 | 55 | 112555 | 8556 | 50483958 |
Tendon necrosis | 22.10 | 9.34 | 5 | 112605 | 5 | 50492509 |
Feeding intolerance | 22.09 | 9.34 | 14 | 112596 | 505 | 50492009 |
Diaphragmatic rupture | 22.02 | 9.34 | 11 | 112599 | 248 | 50492266 |
Rotator cuff syndrome | 21.97 | 9.34 | 66 | 112544 | 11478 | 50481036 |
Femur fracture | 21.71 | 9.34 | 31 | 112579 | 37433 | 50455081 |
Bone marrow granuloma | 21.68 | 9.34 | 6 | 112604 | 21 | 50492493 |
Injection site hyperaesthesia | 21.57 | 9.34 | 7 | 112603 | 47 | 50492467 |
Rectal abscess | 21.21 | 9.34 | 18 | 112592 | 1024 | 50491490 |
Hallucinations, mixed | 21.17 | 9.34 | 35 | 112575 | 4068 | 50488446 |
Hypersensitivity | 21.14 | 9.34 | 344 | 112266 | 214817 | 50277697 |
Product contamination microbial | 21.10 | 9.34 | 10 | 112600 | 200 | 50492314 |
Depersonalisation/derealisation disorder | 20.98 | 9.34 | 19 | 112591 | 1179 | 50491335 |
Meningitis candida | 20.97 | 9.34 | 7 | 112603 | 52 | 50492462 |
Restlessness | 20.94 | 9.34 | 111 | 112499 | 25062 | 50467452 |
Polyneuropathy | 20.91 | 9.34 | 67 | 112543 | 12064 | 50480450 |
Injection site warmth | 20.87 | 9.34 | 3 | 112607 | 13863 | 50478651 |
Cholestatic liver injury | 20.69 | 9.34 | 24 | 112586 | 1997 | 50490517 |
Confabulation | 20.63 | 9.34 | 11 | 112599 | 285 | 50492229 |
Bacteriuria | 20.51 | 9.34 | 15 | 112595 | 686 | 50491828 |
Leukocytosis | 20.48 | 9.34 | 102 | 112508 | 22477 | 50470037 |
Tendon laxity | 20.44 | 9.34 | 4 | 112606 | 0 | 50492514 |
Neurotransmitter level altered | 20.44 | 9.34 | 4 | 112606 | 0 | 50492514 |
Renal vein compression | 20.44 | 9.34 | 4 | 112606 | 0 | 50492514 |
Limb immobilisation | 20.32 | 9.34 | 6 | 112604 | 28 | 50492486 |
Palpitations | 20.25 | 9.34 | 309 | 112301 | 94197 | 50398317 |
Myopathy | 20.06 | 9.34 | 55 | 112555 | 9084 | 50483430 |
Gastrointestinal scarring | 19.99 | 9.34 | 10 | 112600 | 226 | 50492288 |
Neutropenic sepsis | 19.89 | 9.34 | 73 | 112537 | 14074 | 50478440 |
Infrequent bowel movements | 19.84 | 9.34 | 18 | 112592 | 1120 | 50491394 |
Muscle tightness | 19.78 | 9.34 | 59 | 112551 | 10221 | 50482293 |
Live birth | 19.68 | 9.34 | 6 | 112604 | 16402 | 50476112 |
Product deposit | 19.65 | 9.34 | 9 | 112601 | 166 | 50492348 |
Tonsillar haemorrhage | 19.56 | 9.34 | 10 | 112600 | 237 | 50492277 |
Abdominal pain lower | 19.53 | 9.34 | 98 | 112512 | 21658 | 50470856 |
Head injury | 19.40 | 9.34 | 15 | 112595 | 24005 | 50468509 |
Type 2 diabetes mellitus | 19.38 | 9.34 | 29 | 112581 | 34346 | 50458168 |
Vitreous floaters | 19.37 | 9.34 | 39 | 112571 | 5275 | 50487239 |
Medical device site pain | 19.36 | 9.34 | 9 | 112601 | 172 | 50492342 |
Asthma | 19.28 | 9.34 | 118 | 112492 | 89219 | 50403295 |
Exercise tolerance decreased | 19.25 | 9.34 | 37 | 112573 | 4837 | 50487677 |
Nasal polyps | 19.22 | 9.34 | 26 | 112584 | 2528 | 50489986 |
Blood cholesterol increased | 19.17 | 9.34 | 61 | 112549 | 55154 | 50437360 |
Neutrophilic dermatosis | 19.15 | 9.34 | 8 | 112602 | 117 | 50492397 |
Skin oedema | 19.07 | 9.34 | 15 | 112595 | 766 | 50491748 |
Product administration error | 19.06 | 9.34 | 10 | 112600 | 19689 | 50472825 |
Long QT syndrome | 19.06 | 9.34 | 28 | 112582 | 2939 | 50489575 |
Vulvovaginal swelling | 19.05 | 9.34 | 12 | 112598 | 428 | 50492086 |
Cytokine release syndrome | 18.99 | 9.34 | 52 | 112558 | 8582 | 50483932 |
Cholelithiasis | 18.91 | 9.34 | 147 | 112463 | 37826 | 50454688 |
Visual snow syndrome | 18.91 | 9.34 | 5 | 112605 | 14 | 50492500 |
Herpes zoster | 18.89 | 9.34 | 87 | 112523 | 70699 | 50421815 |
COVID-19 | 18.81 | 9.34 | 48 | 112562 | 46614 | 50445900 |
Oesophageal pain | 18.81 | 9.34 | 27 | 112583 | 2775 | 50489739 |
Enterococcal infection | 18.75 | 9.34 | 45 | 112565 | 6853 | 50485661 |
Activated partial thromboplastin time prolonged | 18.75 | 9.34 | 43 | 112567 | 6359 | 50486155 |
Diabetic macroangiopathy | 18.73 | 9.34 | 8 | 112602 | 124 | 50492390 |
Arrhythmia | 18.62 | 9.34 | 132 | 112478 | 33000 | 50459514 |
Acute febrile neutrophilic dermatosis | 18.54 | 9.34 | 26 | 112584 | 2616 | 50489898 |
Escherichia infection | 18.47 | 9.34 | 60 | 112550 | 10881 | 50481633 |
Roseola | 18.21 | 9.34 | 4 | 112606 | 3 | 50492511 |
Eosinophilia | 18.17 | 9.34 | 86 | 112524 | 18566 | 50473948 |
Pulmonary pain | 18.08 | 9.34 | 24 | 112586 | 2291 | 50490223 |
Haematoma | 18.00 | 9.34 | 123 | 112487 | 30387 | 50462127 |
Hypotony of eye | 17.96 | 9.34 | 8 | 112602 | 138 | 50492376 |
Hepatitis infectious mononucleosis | 17.93 | 9.34 | 7 | 112603 | 85 | 50492429 |
Sphingomonas paucimobilis infection | 17.81 | 9.34 | 6 | 112604 | 46 | 50492468 |
Gallbladder rupture | 17.80 | 9.34 | 11 | 112599 | 379 | 50492135 |
Anhedonia | 17.70 | 9.34 | 54 | 112556 | 9470 | 50483044 |
Extremity necrosis | 17.69 | 9.34 | 19 | 112591 | 1452 | 50491062 |
Sensory processing disorder | 17.68 | 9.34 | 4 | 112606 | 4 | 50492510 |
Enterovesical fistula | 17.61 | 9.34 | 12 | 112598 | 490 | 50492024 |
May-Thurner syndrome | 17.55 | 9.34 | 5 | 112605 | 20 | 50492494 |
Toxic skin eruption | 17.48 | 9.34 | 60 | 112550 | 11191 | 50481323 |
Blood creatinine increased | 17.48 | 9.34 | 252 | 112358 | 75908 | 50416606 |
Intentional product misuse | 17.39 | 9.34 | 50 | 112560 | 46684 | 50445830 |
Grip strength decreased | 17.39 | 9.34 | 3 | 112607 | 12118 | 50480396 |
Myoclonus | 17.35 | 9.34 | 71 | 112539 | 14399 | 50478115 |
Visual impairment | 17.33 | 9.34 | 230 | 112380 | 68045 | 50424469 |
Faecal volume decreased | 17.25 | 9.34 | 8 | 112602 | 152 | 50492362 |
Vanishing bile duct syndrome | 17.23 | 9.34 | 13 | 112597 | 624 | 50491890 |
Product substitution issue | 17.12 | 9.34 | 5 | 112605 | 14052 | 50478462 |
Gastrointestinal infection | 16.97 | 9.34 | 44 | 112566 | 7030 | 50485484 |
Bladder trabeculation | 16.97 | 9.34 | 6 | 112604 | 54 | 50492460 |
Cholecystitis acute | 16.85 | 9.34 | 44 | 112566 | 7062 | 50485452 |
Seroconversion test positive | 16.82 | 9.34 | 5 | 112605 | 24 | 50492490 |
Anal fissure | 16.71 | 9.34 | 27 | 112583 | 3078 | 50489436 |
Skin injury | 16.63 | 9.34 | 19 | 112591 | 1555 | 50490959 |
Excessive eye blinking | 16.56 | 9.34 | 15 | 112595 | 931 | 50491583 |
Vaginal flatulence | 16.54 | 9.34 | 9 | 112601 | 243 | 50492271 |
Recall phenomenon | 16.50 | 9.34 | 12 | 112598 | 544 | 50491970 |
Product quality issue | 16.47 | 9.34 | 27 | 112583 | 30831 | 50461683 |
Small fibre neuropathy | 16.40 | 9.34 | 8 | 112602 | 171 | 50492343 |
Musculoskeletal stiffness | 16.32 | 9.34 | 195 | 112415 | 128286 | 50364228 |
Erythema | 16.30 | 9.34 | 434 | 112176 | 145980 | 50346534 |
Intrauterine infection | 16.30 | 9.34 | 7 | 112603 | 110 | 50492404 |
Eczema asteatotic | 16.12 | 9.34 | 9 | 112601 | 256 | 50492258 |
Headache | 16.09 | 9.34 | 943 | 111667 | 505592 | 49986922 |
Pulmonary arterial hypertension | 16.02 | 9.34 | 13 | 112597 | 20306 | 50472208 |
Hypertension | 16.01 | 9.34 | 353 | 112257 | 210850 | 50281664 |
Neuralgia | 15.92 | 9.34 | 93 | 112517 | 21770 | 50470744 |
Haemorrhagic vasculitis | 15.82 | 9.34 | 6 | 112604 | 67 | 50492447 |
Escherichia urinary tract infection | 15.77 | 9.34 | 55 | 112555 | 10340 | 50482174 |
Henoch-Schonlein purpura | 15.75 | 9.34 | 15 | 112595 | 993 | 50491521 |
Staphylococcal scalded skin syndrome | 15.70 | 9.34 | 7 | 112603 | 121 | 50492393 |
Burnout syndrome | 15.67 | 9.34 | 8 | 112602 | 189 | 50492325 |
Foot deformity | 15.51 | 9.34 | 12 | 112598 | 19198 | 50473316 |
Nerve degeneration | 15.51 | 9.34 | 6 | 112604 | 71 | 50492443 |
Toxic neuropathy | 15.50 | 9.34 | 10 | 112600 | 372 | 50492142 |
Hyperchlorhydria | 15.40 | 9.34 | 18 | 112592 | 1510 | 50491004 |
Nephropathy toxic | 15.37 | 9.34 | 46 | 112564 | 7983 | 50484531 |
Vomiting | 15.37 | 9.34 | 1207 | 111403 | 459551 | 50032963 |
Injection site streaking | 15.36 | 9.34 | 5 | 112605 | 34 | 50492480 |
Injection site joint erythema | 15.33 | 9.34 | 3 | 112607 | 0 | 50492514 |
Chills | 15.25 | 9.34 | 301 | 112309 | 96386 | 50396128 |
Rhabdomyolysis | 15.18 | 9.34 | 143 | 112467 | 38884 | 50453630 |
Tongue geographic | 15.14 | 9.34 | 6 | 112604 | 76 | 50492438 |
Infective aneurysm | 15.10 | 9.34 | 10 | 112600 | 389 | 50492125 |
Purple glove syndrome | 15.08 | 9.34 | 8 | 112602 | 205 | 50492309 |
Norovirus test positive | 14.96 | 9.34 | 7 | 112603 | 136 | 50492378 |
Sensory disturbance | 14.95 | 9.34 | 59 | 112551 | 11770 | 50480744 |
Bulimia nervosa | 14.92 | 9.34 | 10 | 112600 | 397 | 50492117 |
Deficiency of bile secretion | 14.92 | 9.34 | 4 | 112606 | 12 | 50492502 |
Abdominal pain upper | 14.91 | 9.34 | 462 | 112148 | 158847 | 50333667 |
Haemolytic anaemia | 14.83 | 9.34 | 50 | 112560 | 9242 | 50483272 |
Red blood cell sedimentation rate abnormal | 14.80 | 9.34 | 9 | 112601 | 16334 | 50476180 |
Mouth ulceration | 14.80 | 9.34 | 110 | 112500 | 27914 | 50464600 |
Neutropenic infection | 14.79 | 9.34 | 15 | 112595 | 1072 | 50491442 |
Skin test positive | 14.76 | 9.34 | 12 | 112598 | 643 | 50491871 |
Ballismus | 14.73 | 9.34 | 6 | 112604 | 82 | 50492432 |
Thermal burn | 14.72 | 9.34 | 33 | 112577 | 4808 | 50487706 |
Fistula discharge | 14.71 | 9.34 | 14 | 112596 | 926 | 50491588 |
Paraesthesia oral | 14.68 | 9.34 | 60 | 112550 | 12161 | 50480353 |
Incorrect route of product administration | 14.64 | 9.34 | 12 | 112598 | 18654 | 50473860 |
Burning mouth syndrome | 14.57 | 9.34 | 10 | 112600 | 413 | 50492101 |
Lividity | 14.57 | 9.34 | 8 | 112602 | 220 | 50492294 |
Intentional self-injury | 14.54 | 9.34 | 18 | 112592 | 23094 | 50469420 |
Vulvovaginal pain | 14.44 | 9.34 | 21 | 112589 | 2184 | 50490330 |
Crystal nephropathy | 14.42 | 9.34 | 13 | 112597 | 802 | 50491712 |
Cerebrovascular accident | 14.32 | 9.34 | 138 | 112472 | 94542 | 50397972 |
Walking disability | 14.30 | 9.34 | 16 | 112594 | 1280 | 50491234 |
Histamine intolerance | 14.24 | 9.34 | 5 | 112605 | 44 | 50492470 |
Flushing | 14.20 | 9.34 | 89 | 112521 | 66926 | 50425588 |
Infusion site streaking | 14.14 | 9.34 | 10 | 112600 | 434 | 50492080 |
Poisoning | 14.11 | 9.34 | 5 | 112605 | 12424 | 50480090 |
Respiratory tract oedema | 14.05 | 9.34 | 10 | 112600 | 438 | 50492076 |
Acid base balance abnormal | 13.97 | 9.34 | 8 | 112602 | 239 | 50492275 |
Tuberculosis gastrointestinal | 13.95 | 9.34 | 9 | 112601 | 335 | 50492179 |
Haematuria | 13.79 | 9.34 | 101 | 112509 | 25512 | 50467002 |
Depressed level of consciousness | 13.78 | 9.34 | 64 | 112546 | 51889 | 50440625 |
Osteonecrosis | 13.68 | 9.34 | 18 | 112592 | 22499 | 50470015 |
Bacteraemia | 13.66 | 9.34 | 66 | 112544 | 14367 | 50478147 |
Foetal exposure during pregnancy | 13.64 | 9.34 | 25 | 112585 | 27334 | 50465180 |
Muscle rupture | 13.59 | 9.34 | 20 | 112590 | 2102 | 50490412 |
Cholestasis | 13.58 | 9.34 | 100 | 112510 | 25301 | 50467213 |
Chronic fatigue syndrome | 13.57 | 9.34 | 14 | 112596 | 1021 | 50491493 |
Spinal fracture | 13.52 | 9.34 | 9 | 112601 | 15564 | 50476950 |
Acute myocardial infarction | 13.51 | 9.34 | 28 | 112582 | 29245 | 50463269 |
Hyperpathia | 13.49 | 9.34 | 4 | 112606 | 19 | 50492495 |
Dysuria | 13.45 | 9.34 | 109 | 112501 | 28395 | 50464119 |
Malignant melanoma | 13.45 | 9.34 | 3 | 112607 | 10105 | 50482409 |
Therapy non-responder | 13.44 | 9.34 | 63 | 112547 | 50959 | 50441555 |
Clostridium colitis | 13.44 | 9.34 | 18 | 112592 | 1734 | 50490780 |
Encephalopathy | 13.35 | 9.34 | 124 | 112486 | 33587 | 50458927 |
Fear of death | 13.32 | 9.34 | 13 | 112597 | 887 | 50491627 |
Genital paraesthesia | 13.32 | 9.34 | 4 | 112606 | 20 | 50492494 |
Anal paraesthesia | 13.32 | 9.34 | 4 | 112606 | 20 | 50492494 |
Portal fibrosis | 13.31 | 9.34 | 8 | 112602 | 262 | 50492252 |
Deafness bilateral | 13.30 | 9.34 | 15 | 112595 | 1211 | 50491303 |
Abdominal tenderness | 13.27 | 9.34 | 41 | 112569 | 7239 | 50485275 |
Somatic dysfunction | 13.26 | 9.34 | 3 | 112607 | 3 | 50492511 |
Cross sensitivity reaction | 13.26 | 9.34 | 19 | 112591 | 1950 | 50490564 |
Iatrogenic injury | 13.08 | 9.34 | 12 | 112598 | 757 | 50491757 |
Skin burning sensation | 13.03 | 9.34 | 51 | 112559 | 10134 | 50482380 |
Fasciitis | 13.02 | 9.34 | 10 | 112600 | 493 | 50492021 |
Eye swelling | 12.97 | 9.34 | 83 | 112527 | 20061 | 50472453 |
Diarrhoea infectious | 12.94 | 9.34 | 13 | 112597 | 919 | 50491595 |
Metastases to kidney | 12.93 | 9.34 | 7 | 112603 | 187 | 50492327 |
Macular degeneration | 12.93 | 9.34 | 8 | 112602 | 14380 | 50478134 |
Toxic encephalopathy | 12.92 | 9.34 | 34 | 112576 | 5481 | 50487033 |
Factor XIII Inhibition | 12.85 | 9.34 | 4 | 112606 | 23 | 50492491 |
Device malfunction | 12.78 | 9.34 | 9 | 112601 | 15112 | 50477402 |
Adverse event | 12.77 | 9.34 | 52 | 112558 | 43711 | 50448803 |
Lymphoedema | 12.76 | 9.34 | 47 | 112563 | 9075 | 50483439 |
Mobility decreased | 12.75 | 9.34 | 115 | 112495 | 79833 | 50412681 |
Dermatitis exfoliative generalised | 12.68 | 9.34 | 24 | 112586 | 3102 | 50489412 |
Peripheral nerve injury | 12.67 | 9.34 | 9 | 112601 | 393 | 50492121 |
Ligament disorder | 12.63 | 9.34 | 9 | 112601 | 395 | 50492119 |
Staphylococcal infection | 12.62 | 9.34 | 128 | 112482 | 35488 | 50457026 |
Rhinitis allergic | 12.62 | 9.34 | 40 | 112570 | 7160 | 50485354 |
Enterocolonic fistula | 12.57 | 9.34 | 4 | 112606 | 25 | 50492489 |
Type IV hypersensitivity reaction | 12.57 | 9.34 | 21 | 112589 | 2461 | 50490053 |
Hot flush | 12.56 | 9.34 | 53 | 112557 | 44116 | 50448398 |
Contusion | 12.50 | 9.34 | 175 | 112435 | 112008 | 50380506 |
Vulvovaginal pruritus | 12.48 | 9.34 | 21 | 112589 | 2475 | 50490039 |
Electrolyte imbalance | 12.48 | 9.34 | 73 | 112537 | 17096 | 50475418 |
Arthritis | 12.45 | 9.34 | 128 | 112482 | 86593 | 50405921 |
Bradycardia | 12.43 | 9.34 | 88 | 112522 | 64338 | 50428176 |
Face oedema | 12.42 | 9.34 | 75 | 112535 | 17764 | 50474750 |
Inappropriate antidiuretic hormone secretion | 12.37 | 9.34 | 60 | 112550 | 13083 | 50479431 |
Road traffic accident | 12.36 | 9.34 | 22 | 112588 | 24330 | 50468184 |
Immune effector cell-associated neurotoxicity syndrome | 12.35 | 9.34 | 14 | 112596 | 1136 | 50491378 |
Exfoliative rash | 12.28 | 9.34 | 21 | 112589 | 2509 | 50490005 |
Fungal infection | 12.26 | 9.34 | 111 | 112499 | 29854 | 50462660 |
Pulmonary hypertension | 12.25 | 9.34 | 36 | 112574 | 33381 | 50459133 |
Quadriparesis | 12.21 | 9.34 | 17 | 112593 | 1699 | 50490815 |
Bronchitis | 12.14 | 9.34 | 161 | 112449 | 103998 | 50388516 |
Blood glucose increased | 12.08 | 9.34 | 101 | 112509 | 71223 | 50421291 |
Enterocutaneous fistula | 12.02 | 9.34 | 14 | 112596 | 1170 | 50491344 |
Dysaesthesia | 11.97 | 9.34 | 26 | 112584 | 3709 | 50488805 |
Calculus bladder | 11.93 | 9.34 | 10 | 112600 | 559 | 50491955 |
Increased bronchial secretion | 11.90 | 9.34 | 16 | 112594 | 1546 | 50490968 |
Transmission of an infectious agent via product | 11.90 | 9.34 | 6 | 112604 | 138 | 50492376 |
Thyroxine increased | 11.89 | 9.34 | 10 | 112600 | 562 | 50491952 |
Feeling jittery | 11.82 | 9.34 | 5 | 112605 | 11155 | 50481359 |
Neoplasm progression | 11.75 | 9.34 | 30 | 112580 | 29127 | 50463387 |
Persistent corneal epithelial defect | 11.73 | 9.34 | 3 | 112607 | 7 | 50492507 |
Mitochondrial enzyme deficiency | 11.72 | 9.34 | 4 | 112606 | 32 | 50492482 |
Leukocyturia | 11.72 | 9.34 | 13 | 112597 | 1030 | 50491484 |
Ligament rupture | 11.66 | 9.34 | 21 | 112589 | 2613 | 50489901 |
Urethral pain | 11.54 | 9.34 | 8 | 112602 | 336 | 50492178 |
Acute psychosis | 11.54 | 9.34 | 19 | 112591 | 2201 | 50490313 |
Thrombotic thrombocytopenic purpura | 11.54 | 9.34 | 25 | 112585 | 3560 | 50488954 |
Foreign body aspiration | 11.52 | 9.34 | 6 | 112604 | 148 | 50492366 |
Lower respiratory tract infection | 11.52 | 9.34 | 146 | 112464 | 95055 | 50397459 |
Tremor | 11.50 | 9.34 | 336 | 112274 | 114567 | 50377947 |
Peritoneal adhesions | 11.49 | 9.34 | 7 | 112603 | 235 | 50492279 |
Incorrect dose administered | 11.49 | 9.34 | 62 | 112548 | 48352 | 50444162 |
Vulvovaginal candidiasis | 11.33 | 9.34 | 21 | 112589 | 2671 | 50489843 |
Single functional kidney | 11.30 | 9.34 | 6 | 112604 | 154 | 50492360 |
Myositis | 11.24 | 9.34 | 41 | 112569 | 7879 | 50484635 |
Hypertensive heart disease | 11.22 | 9.34 | 19 | 112591 | 2251 | 50490263 |
Bronchiectasis | 11.20 | 9.34 | 49 | 112561 | 10234 | 50482280 |
Symmetrical drug-related intertriginous and flexural exanthema | 11.17 | 9.34 | 8 | 112602 | 354 | 50492160 |
Proteus test positive | 11.16 | 9.34 | 6 | 112604 | 158 | 50492356 |
Conjunctival hyperaemia | 11.06 | 9.34 | 18 | 112592 | 2064 | 50490450 |
Toxic shock syndrome | 11.06 | 9.34 | 9 | 112601 | 483 | 50492031 |
Human ehrlichiosis | 11.03 | 9.34 | 6 | 112604 | 162 | 50492352 |
Gallbladder injury | 11.02 | 9.34 | 14 | 112596 | 1280 | 50491234 |
Gastrointestinal disorder | 11.01 | 9.34 | 146 | 112464 | 94310 | 50398204 |
Sense of oppression | 11.00 | 9.34 | 12 | 112598 | 933 | 50491581 |
Mineral metabolism disorder | 10.95 | 9.34 | 3 | 112607 | 10 | 50492504 |
Levator syndrome | 10.95 | 9.34 | 3 | 112607 | 10 | 50492504 |
Influenza | 10.95 | 9.34 | 137 | 112473 | 89401 | 50403113 |
Somnolence | 10.90 | 9.34 | 262 | 112348 | 154723 | 50337791 |
Skin warm | 10.90 | 9.34 | 29 | 112581 | 4706 | 50487808 |
Toxic leukoencephalopathy | 10.87 | 9.34 | 10 | 112600 | 633 | 50491881 |
Ureteric injury | 10.85 | 9.34 | 4 | 112606 | 41 | 50492473 |
Epicondylitis | 10.82 | 9.34 | 17 | 112593 | 1892 | 50490622 |
C-reactive protein decreased | 10.78 | 9.34 | 11 | 112599 | 792 | 50491722 |
Cardiovascular disorder | 10.77 | 9.34 | 49 | 112561 | 10405 | 50482109 |
Tubulointerstitial nephritis and uveitis syndrome | 10.77 | 9.34 | 6 | 112604 | 170 | 50492344 |
Scar excision | 10.77 | 9.34 | 4 | 112606 | 42 | 50492472 |
Plasmapheresis | 10.74 | 9.34 | 7 | 112603 | 265 | 50492249 |
Cardiac failure congestive | 10.74 | 9.34 | 128 | 112482 | 84254 | 50408260 |
Injection site thrombosis | 10.74 | 9.34 | 5 | 112605 | 96 | 50492418 |
Choriocarcinoma | 10.68 | 9.34 | 4 | 112606 | 43 | 50492471 |
Blood disorder | 10.63 | 9.34 | 32 | 112578 | 5573 | 50486941 |
Tachypnoea | 10.61 | 9.34 | 62 | 112548 | 14515 | 50477999 |
Osteonecrosis of jaw | 10.56 | 9.34 | 37 | 112573 | 32489 | 50460025 |
Hepatic encephalopathy | 10.56 | 9.34 | 46 | 112564 | 9590 | 50482924 |
Irritable bowel syndrome | 10.55 | 9.34 | 69 | 112541 | 51372 | 50441142 |
Aural polyp | 10.55 | 9.34 | 5 | 112605 | 100 | 50492414 |
Erythema multiforme | 10.53 | 9.34 | 44 | 112566 | 9006 | 50483508 |
Panic reaction | 10.49 | 9.34 | 24 | 112586 | 3545 | 50488969 |
Electrocardiogram QT prolonged | 10.48 | 9.34 | 168 | 112442 | 51718 | 50440796 |
Hyperinsulinaemia | 10.46 | 9.34 | 5 | 112605 | 102 | 50492412 |
Paraneoplastic syndrome | 10.43 | 9.34 | 9 | 112601 | 524 | 50491990 |
Right ventricular failure | 10.40 | 9.34 | 12 | 112598 | 15881 | 50476633 |
Papule | 10.40 | 9.34 | 27 | 112583 | 4318 | 50488196 |
Collagen disorder | 10.37 | 9.34 | 6 | 112604 | 183 | 50492331 |
Leuconostoc infection | 10.34 | 9.34 | 3 | 112607 | 13 | 50492501 |
Clostridium bacteraemia | 10.31 | 9.34 | 6 | 112604 | 185 | 50492329 |
Refractory anaemia with an excess of blasts | 10.30 | 9.34 | 8 | 112602 | 401 | 50492113 |
Proteus infection | 10.29 | 9.34 | 11 | 112599 | 836 | 50491678 |
Complex regional pain syndrome | 10.28 | 9.34 | 17 | 112593 | 1976 | 50490538 |
Full blood count abnormal | 10.27 | 9.34 | 23 | 112587 | 23365 | 50469149 |
Pneumonia aspiration | 10.25 | 9.34 | 35 | 112575 | 30969 | 50461545 |
Hypoglossal nerve paresis | 10.24 | 9.34 | 5 | 112605 | 107 | 50492407 |
Cardiac arrest | 10.23 | 9.34 | 128 | 112482 | 83523 | 50408991 |
Increased tendency to bruise | 10.22 | 9.34 | 4 | 112606 | 9352 | 50483162 |
Pulmonary function test decreased | 10.19 | 9.34 | 23 | 112587 | 3365 | 50489149 |
Gallbladder disorder | 10.18 | 9.34 | 68 | 112542 | 16674 | 50475840 |
Bone density decreased | 10.17 | 9.34 | 6 | 112604 | 11069 | 50481445 |
Biopsy colon abnormal | 10.16 | 9.34 | 5 | 112605 | 109 | 50492405 |
Post viral fatigue syndrome | 10.08 | 9.34 | 7 | 112603 | 295 | 50492219 |
Lower respiratory tract infection bacterial | 10.03 | 9.34 | 7 | 112603 | 297 | 50492217 |
Haematochezia | 9.97 | 9.34 | 134 | 112476 | 39748 | 50452766 |
Abnormal faeces | 9.97 | 9.34 | 26 | 112584 | 4170 | 50488344 |
Drug withdrawal syndrome | 9.96 | 9.34 | 26 | 112584 | 25055 | 50467459 |
Blood pressure increased | 9.94 | 9.34 | 223 | 112387 | 132909 | 50359605 |
Bovine tuberculosis | 9.93 | 9.34 | 4 | 112606 | 53 | 50492461 |
Thrombocytosis | 9.92 | 9.34 | 29 | 112581 | 4967 | 50487547 |
Renal failure | 9.91 | 9.34 | 309 | 112301 | 106324 | 50386190 |
Drug dependence | 9.90 | 9.34 | 18 | 112592 | 19741 | 50472773 |
Corneal deposits | 9.86 | 9.34 | 6 | 112604 | 201 | 50492313 |
Large intestinal obstruction | 9.84 | 9.34 | 16 | 112594 | 1833 | 50490681 |
Respiratory arrest | 9.83 | 9.34 | 34 | 112576 | 29975 | 50462539 |
Liver function test increased | 9.82 | 9.34 | 27 | 112583 | 25579 | 50466935 |
Loss of personal independence in daily activities | 9.80 | 9.34 | 104 | 112506 | 69946 | 50422568 |
Injection site rash | 9.76 | 9.34 | 13 | 112597 | 16164 | 50476350 |
Purpura fulminans | 9.73 | 9.34 | 4 | 112606 | 56 | 50492458 |
Fracture | 9.68 | 9.34 | 14 | 112596 | 16819 | 50475695 |
Vein discolouration | 9.68 | 9.34 | 6 | 112604 | 208 | 50492306 |
Granulomatous liver disease | 9.65 | 9.34 | 10 | 112600 | 733 | 50491781 |
Neurotoxicity | 9.65 | 9.34 | 61 | 112549 | 14679 | 50477835 |
Intestinal dilatation | 9.64 | 9.34 | 14 | 112596 | 1454 | 50491060 |
Device related infection | 9.63 | 9.34 | 79 | 112531 | 20656 | 50471858 |
Anorectal disorder | 9.61 | 9.34 | 14 | 112596 | 1458 | 50491056 |
Anal skin tags | 9.59 | 9.34 | 7 | 112603 | 319 | 50492195 |
Prescribed overdose | 9.58 | 9.34 | 11 | 112599 | 14589 | 50477925 |
Pyuria | 9.56 | 9.34 | 15 | 112595 | 1668 | 50490846 |
Endocarditis bacterial | 9.56 | 9.34 | 9 | 112601 | 587 | 50491927 |
Osteoarthritis | 9.54 | 9.34 | 102 | 112508 | 68504 | 50424010 |
Pre-eclampsia | 9.54 | 9.34 | 3 | 112607 | 8041 | 50484473 |
Rectal tenesmus | 9.53 | 9.34 | 8 | 112602 | 448 | 50492066 |
Rash erythematous | 9.51 | 9.34 | 119 | 112491 | 34733 | 50457781 |
Vulvovaginal inflammation | 9.48 | 9.34 | 9 | 112601 | 593 | 50491921 |
Diarrhoea haemorrhagic | 9.47 | 9.34 | 38 | 112572 | 7637 | 50484877 |
Vascular fragility | 9.47 | 9.34 | 5 | 112605 | 127 | 50492387 |
Retinal detachment | 9.46 | 9.34 | 29 | 112581 | 5100 | 50487414 |
Drug level decreased | 9.43 | 9.34 | 34 | 112576 | 6499 | 50486015 |
Sciatica | 9.41 | 9.34 | 21 | 112589 | 21361 | 50471153 |
Injection site urticaria | 9.40 | 9.34 | 8 | 112602 | 12209 | 50480305 |
Therapeutic response unexpected | 9.39 | 9.34 | 13 | 112597 | 15902 | 50476612 |
Oxygen saturation decreased | 9.36 | 9.34 | 111 | 112499 | 73137 | 50419377 |
Proctitis | 9.35 | 9.34 | 16 | 112594 | 1912 | 50490602 |
Hormone level abnormal | 9.34 | 9.34 | 17 | 112593 | 2132 | 50490382 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Tendon pain | 706.51 | 10.29 | 267 | 84516 | 2233 | 29487511 |
Tendonitis | 572.25 | 10.29 | 329 | 84454 | 7632 | 29482112 |
Tendon rupture | 420.24 | 10.29 | 248 | 84535 | 6047 | 29483697 |
Tendon disorder | 252.19 | 10.29 | 129 | 84654 | 2349 | 29487395 |
Pathogen resistance | 213.73 | 10.29 | 181 | 84602 | 7935 | 29481809 |
Death | 206.39 | 10.29 | 420 | 84363 | 341664 | 29148080 |
Tendon discomfort | 176.45 | 10.29 | 53 | 84730 | 194 | 29489550 |
Toxic epidermal necrolysis | 165.51 | 10.29 | 231 | 84552 | 17922 | 29471822 |
Drug abuse | 153.40 | 10.29 | 23 | 84760 | 79860 | 29409884 |
Drug hypersensitivity | 151.68 | 10.29 | 486 | 84297 | 67920 | 29421824 |
Completed suicide | 146.21 | 10.29 | 39 | 84744 | 90207 | 29399537 |
Drug reaction with eosinophilia and systemic symptoms | 122.57 | 10.29 | 257 | 84526 | 27735 | 29462009 |
Drug interaction | 121.80 | 10.29 | 974 | 83809 | 196411 | 29293333 |
Myocardial infarction | 114.67 | 10.29 | 89 | 84694 | 110207 | 29379537 |
Joint noise | 113.90 | 10.29 | 47 | 84736 | 506 | 29489238 |
Clostridium difficile colitis | 111.40 | 10.29 | 162 | 84621 | 13050 | 29476694 |
Drug resistance | 100.46 | 10.29 | 203 | 84580 | 21337 | 29468407 |
Tinnitus | 96.41 | 10.29 | 166 | 84617 | 15448 | 29474296 |
Choroiditis | 96.39 | 10.29 | 50 | 84733 | 938 | 29488806 |
Myalgia | 92.65 | 10.29 | 439 | 84344 | 73580 | 29416164 |
Tubulointerstitial nephritis | 86.75 | 10.29 | 170 | 84613 | 17473 | 29472271 |
Paraesthesia | 82.26 | 10.29 | 339 | 84444 | 53506 | 29436238 |
Product dose omission issue | 82.24 | 10.29 | 93 | 84690 | 96290 | 29393454 |
Eye pain | 79.23 | 10.29 | 129 | 84654 | 11466 | 29478278 |
Fall | 72.18 | 10.29 | 263 | 84520 | 176915 | 29312829 |
Neuralgia | 71.63 | 10.29 | 119 | 84664 | 10755 | 29478989 |
Septic shock | 71.08 | 10.29 | 361 | 84422 | 62199 | 29427545 |
Hyperacusis | 70.44 | 10.29 | 37 | 84746 | 713 | 29489031 |
Intentional overdose | 69.69 | 10.29 | 13 | 84770 | 38515 | 29451229 |
Night sweats | 67.57 | 10.29 | 139 | 84644 | 14793 | 29474951 |
Toxicity to various agents | 66.70 | 10.29 | 264 | 84519 | 173397 | 29316347 |
Overdose | 64.88 | 10.29 | 80 | 84703 | 79739 | 29410005 |
Solar lentigo | 64.68 | 10.29 | 29 | 84754 | 388 | 29489356 |
Muscle twitching | 64.17 | 10.29 | 96 | 84687 | 7930 | 29481814 |
Cerebrovascular accident | 63.66 | 10.29 | 76 | 84707 | 76835 | 29412909 |
Panic attack | 61.51 | 10.29 | 96 | 84687 | 8230 | 29481514 |
Torsade de pointes | 61.04 | 10.29 | 85 | 84698 | 6576 | 29483168 |
Stevens-Johnson syndrome | 58.20 | 10.29 | 139 | 84644 | 16358 | 29473386 |
Arthralgia | 58.19 | 10.29 | 634 | 84149 | 138983 | 29350761 |
Dysplastic naevus | 57.64 | 10.29 | 27 | 84756 | 402 | 29489342 |
Pruritus genital | 57.53 | 10.29 | 29 | 84754 | 511 | 29489233 |
Dysbiosis | 56.43 | 10.29 | 26 | 84757 | 372 | 29489372 |
Trichoglossia | 55.94 | 10.29 | 18 | 84765 | 87 | 29489657 |
Photodermatosis | 55.90 | 10.29 | 27 | 84756 | 432 | 29489312 |
Hyperfibrinolysis | 54.68 | 10.29 | 13 | 84770 | 12 | 29489732 |
Foetal exposure during pregnancy | 54.12 | 10.29 | 15 | 84768 | 33852 | 29455892 |
Muscle rupture | 53.52 | 10.29 | 45 | 84738 | 1952 | 29487792 |
Intraocular pressure increased | 51.38 | 10.29 | 66 | 84717 | 4723 | 29485021 |
Pseudomembranous colitis | 50.79 | 10.29 | 49 | 84734 | 2548 | 29487196 |
Candida infection | 50.21 | 10.29 | 125 | 84658 | 15100 | 29474644 |
Cardiac failure congestive | 49.38 | 10.29 | 90 | 84693 | 76491 | 29413253 |
Fistula | 47.72 | 10.29 | 66 | 84717 | 5073 | 29484671 |
Clostridium difficile infection | 46.53 | 10.29 | 126 | 84657 | 16015 | 29473729 |
Wrong technique in product usage process | 46.48 | 10.29 | 16 | 84767 | 31412 | 29458332 |
Pyrexia | 45.92 | 10.29 | 1113 | 83670 | 286509 | 29203235 |
Ependymoma | 45.35 | 10.29 | 11 | 84772 | 12 | 29489732 |
Abdominal abscess | 44.68 | 10.29 | 55 | 84728 | 3769 | 29485975 |
Ligament pain | 44.01 | 10.29 | 11 | 84772 | 15 | 29489729 |
Spinal muscular atrophy | 41.48 | 10.29 | 19 | 84764 | 268 | 29489476 |
Rash morbilliform | 41.32 | 10.29 | 43 | 84740 | 2450 | 29487294 |
Condition aggravated | 40.44 | 10.29 | 616 | 84167 | 145679 | 29344065 |
Impaired work ability | 40.23 | 10.29 | 64 | 84719 | 5576 | 29484168 |
Factor V inhibition | 40.08 | 10.29 | 16 | 84767 | 157 | 29489587 |
Pseudomonas infection | 39.97 | 10.29 | 93 | 84690 | 10759 | 29478985 |
Acute myocardial infarction | 38.87 | 10.29 | 49 | 84734 | 48389 | 29441355 |
Rash maculo-papular | 38.71 | 10.29 | 155 | 84628 | 24134 | 29465610 |
Colitis | 38.08 | 10.29 | 184 | 84599 | 31064 | 29458680 |
Eosinophilia | 37.40 | 10.29 | 144 | 84639 | 22017 | 29467727 |
Hyphaema | 37.29 | 10.29 | 21 | 84762 | 467 | 29489277 |
Linear IgA disease | 37.11 | 10.29 | 32 | 84751 | 1437 | 29488307 |
Anal fissure | 37.11 | 10.29 | 43 | 84740 | 2765 | 29486979 |
Tendon injury | 36.93 | 10.29 | 25 | 84758 | 778 | 29488966 |
Burning sensation | 36.87 | 10.29 | 115 | 84668 | 15823 | 29473921 |
Acute generalised exanthematous pustulosis | 36.63 | 10.29 | 61 | 84722 | 5522 | 29484222 |
Suicide attempt | 36.07 | 10.29 | 27 | 84756 | 34083 | 29455661 |
Rheumatoid arthritis | 35.91 | 10.29 | 24 | 84759 | 32128 | 29457616 |
Cutaneous vasculitis | 35.00 | 10.29 | 45 | 84738 | 3223 | 29486521 |
Diastasis recti abdominis | 34.57 | 10.29 | 9 | 84774 | 16 | 29489728 |
Hypertension | 34.30 | 10.29 | 195 | 84588 | 116419 | 29373325 |
Blood glucose increased | 33.99 | 10.29 | 74 | 84709 | 58910 | 29430834 |
Musculoskeletal injury | 33.84 | 10.29 | 13 | 84770 | 114 | 29489630 |
Photosensitivity reaction | 33.73 | 10.29 | 79 | 84704 | 9179 | 29480565 |
Cross sensitivity reaction | 32.92 | 10.29 | 28 | 84755 | 1234 | 29488510 |
Aortic valve prolapse | 32.86 | 10.29 | 8 | 84775 | 9 | 29489735 |
COVID-19 | 32.63 | 10.29 | 33 | 84750 | 35981 | 29453763 |
Pelvic abscess | 32.25 | 10.29 | 24 | 84759 | 870 | 29488874 |
Yellow fever | 31.51 | 10.29 | 7 | 84776 | 3 | 29489741 |
Sputum increased | 31.51 | 10.29 | 33 | 84750 | 1894 | 29487850 |
Urosepsis | 31.08 | 10.29 | 84 | 84699 | 10662 | 29479082 |
Abdominal pain | 30.75 | 10.29 | 552 | 84231 | 134805 | 29354939 |
Clostridium test positive | 30.66 | 10.29 | 34 | 84749 | 2083 | 29487661 |
Injection site pain | 30.24 | 10.29 | 29 | 84754 | 32417 | 29457327 |
Cardiac failure | 30.08 | 10.29 | 121 | 84662 | 79166 | 29410578 |
Muscle atrophy | 29.95 | 10.29 | 61 | 84722 | 6445 | 29483299 |
Henoch-Schonlein purpura | 29.91 | 10.29 | 27 | 84756 | 1289 | 29488455 |
Visual acuity reduced | 29.62 | 10.29 | 102 | 84681 | 14774 | 29474970 |
Escherichia infection | 29.47 | 10.29 | 62 | 84721 | 6702 | 29483042 |
Acute kidney injury | 29.31 | 10.29 | 980 | 83803 | 264287 | 29225457 |
Undersensing | 29.17 | 10.29 | 7 | 84776 | 7 | 29489737 |
Anuria | 29.03 | 10.29 | 76 | 84707 | 9465 | 29480279 |
Intentional product misuse | 28.93 | 10.29 | 34 | 84749 | 34627 | 29455117 |
Infective aneurysm | 28.88 | 10.29 | 18 | 84765 | 485 | 29489259 |
Dyspnoea | 28.88 | 10.29 | 715 | 84068 | 326017 | 29163727 |
Therapeutic product effect incomplete | 28.28 | 10.29 | 43 | 84740 | 39262 | 29450482 |
Infective pulmonary exacerbation of cystic fibrosis | 28.15 | 10.29 | 58 | 84725 | 6178 | 29483566 |
Sphingomonas paucimobilis infection | 28.06 | 10.29 | 9 | 84774 | 43 | 29489701 |
Fixed eruption | 27.99 | 10.29 | 25 | 84758 | 1177 | 29488567 |
Connective tissue disorder | 27.97 | 10.29 | 13 | 84770 | 190 | 29489554 |
Chest pain | 27.91 | 10.29 | 197 | 84586 | 111776 | 29377968 |
Penis injury | 27.86 | 10.29 | 14 | 84769 | 245 | 29489499 |
Pain in extremity | 27.83 | 10.29 | 458 | 84325 | 109975 | 29379769 |
Prostatitis | 27.77 | 10.29 | 49 | 84734 | 4648 | 29485096 |
Coronary artery disease | 27.53 | 10.29 | 53 | 84730 | 44137 | 29445607 |
Renal tubular necrosis | 27.50 | 10.29 | 97 | 84686 | 14218 | 29475526 |
Vitreous floaters | 27.37 | 10.29 | 39 | 84744 | 3082 | 29486662 |
Anxiety | 27.35 | 10.29 | 369 | 84414 | 84996 | 29404748 |
Palpitations | 27.02 | 10.29 | 173 | 84610 | 32431 | 29457313 |
Bradycardia | 26.93 | 10.29 | 97 | 84686 | 65532 | 29424212 |
Plantar fasciitis | 26.63 | 10.29 | 25 | 84758 | 1256 | 29488488 |
Rectal abscess | 26.61 | 10.29 | 22 | 84761 | 932 | 29488812 |
Anal fistula | 26.41 | 10.29 | 45 | 84738 | 4150 | 29485594 |
Pneumococcal sepsis | 26.32 | 10.29 | 21 | 84762 | 845 | 29488899 |
Anal abscess | 26.29 | 10.29 | 51 | 84732 | 5200 | 29484544 |
Motor neurone disease | 26.07 | 10.29 | 15 | 84768 | 348 | 29489396 |
Penile haemorrhage | 25.88 | 10.29 | 18 | 84765 | 586 | 29489158 |
Crohn's disease | 25.51 | 10.29 | 37 | 84746 | 2972 | 29486772 |
Aspergillus infection | 25.08 | 10.29 | 77 | 84706 | 10504 | 29479240 |
Yellow fever vaccine-associated viscerotropic disease | 24.29 | 10.29 | 5 | 84778 | 0 | 29489744 |
Sensory processing disorder | 24.29 | 10.29 | 5 | 84778 | 0 | 29489744 |
Malignant neoplasm progression | 24.22 | 10.29 | 119 | 84664 | 73740 | 29416004 |
Pulmonary embolism | 24.13 | 10.29 | 125 | 84658 | 76409 | 29413335 |
Neuropathy peripheral | 23.99 | 10.29 | 310 | 84473 | 70717 | 29419027 |
Walking aid user | 23.63 | 10.29 | 25 | 84758 | 1452 | 29488292 |
Premature baby | 23.55 | 10.29 | 10 | 84773 | 17270 | 29472474 |
Psoriasis | 23.43 | 10.29 | 35 | 84748 | 32192 | 29457552 |
Cystic fibrosis | 23.42 | 10.29 | 25 | 84758 | 1467 | 29488277 |
Respiratory tract infection bacterial | 23.34 | 10.29 | 17 | 84766 | 596 | 29489148 |
Pouchitis | 23.34 | 10.29 | 17 | 84766 | 596 | 29489148 |
Acinetobacter infection | 23.29 | 10.29 | 21 | 84762 | 1001 | 29488743 |
Enterococcal infection | 23.28 | 10.29 | 64 | 84719 | 8204 | 29481540 |
Phlebitis infective | 23.27 | 10.29 | 10 | 84773 | 120 | 29489624 |
Geotrichum infection | 23.25 | 10.29 | 15 | 84768 | 430 | 29489314 |
Hypnagogic hallucination | 23.16 | 10.29 | 8 | 84775 | 50 | 29489694 |
Hepatitis cholestatic | 23.15 | 10.29 | 57 | 84726 | 6836 | 29482908 |
Uveitis | 23.05 | 10.29 | 52 | 84731 | 5895 | 29483849 |
Visual impairment | 23.01 | 10.29 | 155 | 84628 | 29553 | 29460191 |
Nosocomial infection | 22.67 | 10.29 | 21 | 84762 | 1037 | 29488707 |
Angina pectoris | 22.52 | 10.29 | 28 | 84755 | 27822 | 29461922 |
Chest injury | 22.47 | 10.29 | 24 | 84759 | 1409 | 29488335 |
Diabetic ketoacidosis | 22.39 | 10.29 | 9 | 84774 | 16064 | 29473680 |
Hospitalisation | 22.34 | 10.29 | 63 | 84720 | 45925 | 29443819 |
Corneal deposits | 22.28 | 10.29 | 11 | 84772 | 185 | 29489559 |
Ischaemic stroke | 22.17 | 10.29 | 9 | 84774 | 15968 | 29473776 |
Necrotising retinitis | 22.02 | 10.29 | 18 | 84765 | 750 | 29488994 |
Defaecation urgency | 21.81 | 10.29 | 26 | 84757 | 1723 | 29488021 |
Lumbosacral plexus injury | 21.67 | 10.29 | 6 | 84777 | 15 | 29489729 |
Weight increased | 21.57 | 10.29 | 130 | 84653 | 76537 | 29413207 |
Multiple organ dysfunction syndrome | 21.53 | 10.29 | 276 | 84507 | 62840 | 29426904 |
Coma | 21.50 | 10.29 | 51 | 84732 | 39399 | 29450345 |
Febrile neutropenia | 21.47 | 10.29 | 446 | 84337 | 111794 | 29377950 |
Sopor | 21.31 | 10.29 | 3 | 84780 | 10931 | 29478813 |
Orchitis | 21.22 | 10.29 | 23 | 84760 | 1373 | 29488371 |
Chronic gastrointestinal bleeding | 21.06 | 10.29 | 12 | 84771 | 273 | 29489471 |
Painful respiration | 20.82 | 10.29 | 21 | 84762 | 1153 | 29488591 |
Chronic obstructive pulmonary disease | 20.72 | 10.29 | 55 | 84728 | 40900 | 29448844 |
Abscess intestinal | 20.72 | 10.29 | 23 | 84760 | 1411 | 29488333 |
Chronic fatigue syndrome | 20.68 | 10.29 | 12 | 84771 | 283 | 29489461 |
Hypoaesthesia | 20.49 | 10.29 | 239 | 84544 | 53228 | 29436516 |
Megacolon | 20.25 | 10.29 | 24 | 84759 | 1581 | 29488163 |
Weight bearing difficulty | 20.05 | 10.29 | 18 | 84765 | 853 | 29488891 |
Cardio-respiratory arrest | 19.96 | 10.29 | 76 | 84707 | 50525 | 29439219 |
Ischaemic cerebral infarction | 19.72 | 10.29 | 19 | 84764 | 986 | 29488758 |
Enterocutaneous fistula | 19.61 | 10.29 | 17 | 84766 | 769 | 29488975 |
Neuroleptic malignant syndrome | 19.49 | 10.29 | 11 | 84772 | 16137 | 29473607 |
Abscess | 19.49 | 10.29 | 67 | 84716 | 9695 | 29480049 |
Aeromonas infection | 19.48 | 10.29 | 11 | 84772 | 246 | 29489498 |
Prolapse | 19.43 | 10.29 | 4 | 84779 | 0 | 29489744 |
Yellow fever vaccine-associated neurotropic disease | 19.43 | 10.29 | 4 | 84779 | 0 | 29489744 |
Posterior tibial tendon dysfunction | 19.43 | 10.29 | 4 | 84779 | 0 | 29489744 |
Metastases to liver | 19.41 | 10.29 | 5 | 84778 | 11851 | 29477893 |
Organic brain syndrome | 19.32 | 10.29 | 11 | 84772 | 250 | 29489494 |
Incorrect dose administered | 19.31 | 10.29 | 41 | 84742 | 32943 | 29456801 |
Anxiety disorder | 19.09 | 10.29 | 23 | 84760 | 1541 | 29488203 |
Nasopharyngitis | 19.06 | 10.29 | 97 | 84686 | 59568 | 29430176 |
Septic embolus | 19.02 | 10.29 | 19 | 84764 | 1031 | 29488713 |
Dermatitis bullous | 18.96 | 10.29 | 48 | 84735 | 5858 | 29483886 |
Product quality issue | 18.94 | 10.29 | 11 | 84772 | 15884 | 29473860 |
Auditory disorder | 18.89 | 10.29 | 11 | 84772 | 261 | 29489483 |
Clostridial infection | 18.85 | 10.29 | 34 | 84749 | 3281 | 29486463 |
Increased viscosity of bronchial secretion | 18.79 | 10.29 | 10 | 84773 | 198 | 29489546 |
Leukocytosis | 18.65 | 10.29 | 114 | 84669 | 21028 | 29468716 |
Gluten sensitivity | 18.65 | 10.29 | 6 | 84777 | 29 | 29489715 |
Aortic aneurysm rupture | 18.61 | 10.29 | 18 | 84765 | 939 | 29488805 |
Gastrointestinal inflammation | 18.59 | 10.29 | 32 | 84751 | 2976 | 29486768 |
Infusion related reaction | 18.58 | 10.29 | 64 | 84719 | 43822 | 29445922 |
Urinary tract infection | 18.55 | 10.29 | 301 | 84482 | 72053 | 29417691 |
Oxidative stress | 18.47 | 10.29 | 7 | 84776 | 59 | 29489685 |
Trichosporon infection | 18.35 | 10.29 | 15 | 84768 | 625 | 29489119 |
Food intolerance | 18.35 | 10.29 | 19 | 84764 | 1076 | 29488668 |
Muscle fatigue | 18.35 | 10.29 | 20 | 84763 | 1202 | 29488542 |
Mucosal disorder | 17.98 | 10.29 | 22 | 84761 | 1498 | 29488246 |
Deep vein thrombosis | 17.95 | 10.29 | 94 | 84689 | 57305 | 29432439 |
Musculoskeletal discomfort | 17.77 | 10.29 | 49 | 84734 | 6292 | 29483452 |
Systemic candida | 17.74 | 10.29 | 30 | 84753 | 2750 | 29486994 |
Nail bed inflammation | 17.73 | 10.29 | 9 | 84774 | 161 | 29489583 |
Impaired quality of life | 17.70 | 10.29 | 29 | 84754 | 2590 | 29487154 |
Metabolic disorder | 17.43 | 10.29 | 35 | 84748 | 3660 | 29486084 |
Magnesium deficiency | 17.42 | 10.29 | 7 | 84776 | 70 | 29489674 |
Stoma closure | 17.39 | 10.29 | 8 | 84775 | 114 | 29489630 |
Stenotrophomonas infection | 17.38 | 10.29 | 23 | 84760 | 1694 | 29488050 |
Intentional self-injury | 17.32 | 10.29 | 7 | 84776 | 12454 | 29477290 |
Seizure | 17.27 | 10.29 | 177 | 84606 | 92946 | 29396798 |
Epistaxis | 17.12 | 10.29 | 83 | 84700 | 51621 | 29438123 |
Nephritis allergic | 17.08 | 10.29 | 12 | 84771 | 397 | 29489347 |
Leukocyturia | 17.08 | 10.29 | 13 | 84770 | 488 | 29489256 |
Lower respiratory tract infection bacterial | 16.96 | 10.29 | 11 | 84772 | 318 | 29489426 |
Muscle tightness | 16.89 | 10.29 | 38 | 84745 | 4300 | 29485444 |
Therapeutic response decreased | 16.86 | 10.29 | 28 | 84755 | 24683 | 29465061 |
Corneal opacity | 16.80 | 10.29 | 13 | 84770 | 500 | 29489244 |
Haematospermia | 16.72 | 10.29 | 11 | 84772 | 326 | 29489418 |
Asthma | 16.72 | 10.29 | 46 | 84737 | 33803 | 29455941 |
Urinary tract obstruction | 16.48 | 10.29 | 32 | 84751 | 3265 | 29486479 |
Obesity | 16.46 | 10.29 | 4 | 84779 | 9859 | 29479885 |
Mental fatigue | 16.44 | 10.29 | 7 | 84776 | 82 | 29489662 |
Sleep disorder | 16.42 | 10.29 | 123 | 84660 | 24263 | 29465481 |
Rash erythematous | 16.40 | 10.29 | 112 | 84671 | 21450 | 29468294 |
Diabetes mellitus | 16.25 | 10.29 | 59 | 84724 | 39772 | 29449972 |
Retinitis viral | 16.22 | 10.29 | 7 | 84776 | 85 | 29489659 |
Intestinal fistula | 16.17 | 10.29 | 16 | 84767 | 858 | 29488886 |
Catatonia | 16.14 | 10.29 | 38 | 84745 | 4430 | 29485314 |
Cough | 16.05 | 10.29 | 261 | 84522 | 126466 | 29363278 |
Cardiac disorder | 16.00 | 10.29 | 54 | 84729 | 37209 | 29452535 |
Cerebral infarction | 15.89 | 10.29 | 29 | 84754 | 24646 | 29465098 |
Increased bronchial secretion | 15.73 | 10.29 | 21 | 84762 | 1560 | 29488184 |
Pruritus | 15.59 | 10.29 | 442 | 84341 | 116407 | 29373337 |
Dysuria | 15.57 | 10.29 | 114 | 84669 | 22326 | 29467418 |
Product administration error | 15.55 | 10.29 | 11 | 84772 | 14299 | 29475445 |
Inflammation | 15.51 | 10.29 | 115 | 84668 | 22613 | 29467131 |
Crystal nephropathy | 15.50 | 10.29 | 11 | 84772 | 370 | 29489374 |
Angina bullosa haemorrhagica | 15.39 | 10.29 | 6 | 84777 | 55 | 29489689 |
Flushing | 15.39 | 10.29 | 38 | 84745 | 28954 | 29460790 |
Somnolence | 15.27 | 10.29 | 184 | 84599 | 93771 | 29395973 |
Generalised oedema | 15.26 | 10.29 | 68 | 84715 | 11097 | 29478647 |
Ligament injury | 15.24 | 10.29 | 10 | 84773 | 295 | 29489449 |
Vanishing bile duct syndrome | 15.24 | 10.29 | 13 | 84770 | 575 | 29489169 |
Fluorosis | 15.20 | 10.29 | 6 | 84777 | 57 | 29489687 |
Abscess bacterial | 15.19 | 10.29 | 8 | 84775 | 155 | 29489589 |
Treatment noncompliance | 15.14 | 10.29 | 29 | 84754 | 24198 | 29465546 |
Parosmia | 15.11 | 10.29 | 20 | 84763 | 1474 | 29488270 |
Blood pressure increased | 15.07 | 10.29 | 137 | 84646 | 73666 | 29416078 |
Accidental exposure to product | 15.01 | 10.29 | 6 | 84777 | 10747 | 29478997 |
Cystitis | 14.91 | 10.29 | 55 | 84728 | 8237 | 29481507 |
Injection site haemorrhage | 14.80 | 10.29 | 3 | 84780 | 8383 | 29481361 |
Ligament disorder | 14.78 | 10.29 | 7 | 84776 | 107 | 29489637 |
Lip erosion | 14.68 | 10.29 | 12 | 84771 | 500 | 29489244 |
Eye infection fungal | 14.67 | 10.29 | 10 | 84773 | 315 | 29489429 |
Gingival recession | 14.66 | 10.29 | 11 | 84772 | 404 | 29489340 |
Oesophageal mucosa erythema | 14.64 | 10.29 | 5 | 84778 | 30 | 29489714 |
Subacute cutaneous lupus erythematosus | 14.57 | 10.29 | 15 | 84768 | 844 | 29488900 |
Nutritional condition abnormal | 14.54 | 10.29 | 11 | 84772 | 409 | 29489335 |
Aortic aneurysm | 14.49 | 10.29 | 45 | 84738 | 6175 | 29483569 |
Platelet count decreased | 14.46 | 10.29 | 212 | 84571 | 104460 | 29385284 |
Hyperkalaemia | 14.32 | 10.29 | 110 | 84673 | 61282 | 29428462 |
Toxic encephalopathy | 14.30 | 10.29 | 37 | 84746 | 4575 | 29485169 |
Intestinal stenosis | 14.27 | 10.29 | 22 | 84761 | 1866 | 29487878 |
Pruritus allergic | 14.24 | 10.29 | 8 | 84775 | 177 | 29489567 |
Myocardial ischaemia | 14.16 | 10.29 | 15 | 84768 | 16013 | 29473731 |
Cardiac arrest | 14.15 | 10.29 | 167 | 84616 | 85424 | 29404320 |
Interstitial lung disease | 14.14 | 10.29 | 102 | 84681 | 57616 | 29432128 |
Sitting disability | 14.11 | 10.29 | 7 | 84776 | 119 | 29489625 |
Subdural haematoma | 13.98 | 10.29 | 19 | 84764 | 18174 | 29471570 |
Joint stiffness | 13.94 | 10.29 | 59 | 84724 | 9414 | 29480330 |
Therapeutic product ineffective for unapproved indication | 13.92 | 10.29 | 4 | 84779 | 12 | 29489732 |
Renal abscess | 13.85 | 10.29 | 8 | 84775 | 187 | 29489557 |
Haemorrhoids thrombosed | 13.85 | 10.29 | 8 | 84775 | 187 | 29489557 |
Blood triglycerides increased | 13.77 | 10.29 | 10 | 84773 | 12824 | 29476920 |
Gallbladder polyp | 13.74 | 10.29 | 10 | 84773 | 350 | 29489394 |
Mucosal hyperaemia | 13.68 | 10.29 | 4 | 84779 | 13 | 29489731 |
Scrotal pain | 13.68 | 10.29 | 14 | 84769 | 782 | 29488962 |
Roseolovirus test positive | 13.67 | 10.29 | 6 | 84777 | 76 | 29489668 |
Mucosal atrophy | 13.67 | 10.29 | 6 | 84777 | 76 | 29489668 |
Peroneal nerve palsy | 13.67 | 10.29 | 26 | 84757 | 2613 | 29487131 |
Thrombotic thrombocytopenic purpura | 13.52 | 10.29 | 29 | 84754 | 3177 | 29486567 |
Actinic keratosis | 13.46 | 10.29 | 32 | 84751 | 3754 | 29485990 |
Cervicobrachial syndrome | 13.41 | 10.29 | 9 | 84774 | 276 | 29489468 |
Otorrhoea | 13.40 | 10.29 | 11 | 84772 | 461 | 29489283 |
Drug ineffective for unapproved indication | 13.40 | 10.29 | 78 | 84705 | 14136 | 29475608 |
Hyperthyroidism | 13.40 | 10.29 | 4 | 84779 | 8604 | 29481140 |
Large intestinal stenosis | 13.22 | 10.29 | 18 | 84765 | 1363 | 29488381 |
Drug dependence | 13.21 | 10.29 | 25 | 84758 | 20956 | 29468788 |
Pseudopolyp | 13.19 | 10.29 | 8 | 84775 | 205 | 29489539 |
Anal stenosis | 13.18 | 10.29 | 7 | 84776 | 138 | 29489606 |
Bronchopulmonary aspergillosis | 13.14 | 10.29 | 70 | 84713 | 12274 | 29477470 |
Aspartate aminotransferase | 13.14 | 10.29 | 6 | 84777 | 84 | 29489660 |
Glomerular filtration rate decreased | 13.14 | 10.29 | 8 | 84775 | 11258 | 29478486 |
Cogwheel rigidity | 13.13 | 10.29 | 17 | 84766 | 1226 | 29488518 |
Proctalgia | 13.11 | 10.29 | 34 | 84749 | 4211 | 29485533 |
Underdose | 13.06 | 10.29 | 9 | 84774 | 11860 | 29477884 |
Faciobrachial dystonic seizure | 13.04 | 10.29 | 4 | 84779 | 16 | 29489728 |
Disease complication | 12.97 | 10.29 | 24 | 84759 | 2362 | 29487382 |
Epididymitis | 12.95 | 10.29 | 23 | 84760 | 2192 | 29487552 |
Food allergy | 12.90 | 10.29 | 15 | 84768 | 968 | 29488776 |
Pseudomonal sepsis | 12.85 | 10.29 | 27 | 84756 | 2915 | 29486829 |
Post infection glomerulonephritis | 12.85 | 10.29 | 4 | 84779 | 17 | 29489727 |
Sacroiliitis | 12.83 | 10.29 | 16 | 84767 | 1111 | 29488633 |
Joint instability | 12.83 | 10.29 | 10 | 84773 | 389 | 29489355 |
Throat tightness | 12.73 | 10.29 | 47 | 84736 | 7044 | 29482700 |
Graft versus host disease | 12.68 | 10.29 | 58 | 84725 | 9570 | 29480174 |
Klebsiella infection | 12.60 | 10.29 | 48 | 84735 | 7301 | 29482443 |
Drug intolerance | 12.59 | 10.29 | 84 | 84699 | 48295 | 29441449 |
Irritability | 12.58 | 10.29 | 28 | 84755 | 22124 | 29467620 |
Necrotising fasciitis | 12.57 | 10.29 | 29 | 84754 | 3336 | 29486408 |
Withdrawal syndrome | 12.55 | 10.29 | 8 | 84775 | 10984 | 29478760 |
Ligament rupture | 12.52 | 10.29 | 14 | 84769 | 866 | 29488878 |
Spinal meningeal cyst | 12.50 | 10.29 | 3 | 84780 | 3 | 29489741 |
Vertebral artery hypoplasia | 12.50 | 10.29 | 3 | 84780 | 3 | 29489741 |
Glare | 12.48 | 10.29 | 6 | 84777 | 95 | 29489649 |
Blood creatine phosphokinase increased | 12.46 | 10.29 | 67 | 84716 | 40577 | 29449167 |
Perirectal abscess | 12.40 | 10.29 | 18 | 84765 | 1447 | 29488297 |
Pseudoporphyria | 12.39 | 10.29 | 9 | 84774 | 314 | 29489430 |
Synovitis | 12.33 | 10.29 | 8 | 84775 | 10882 | 29478862 |
Necrosis | 12.29 | 10.29 | 37 | 84746 | 4993 | 29484751 |
Toxic skin eruption | 12.27 | 10.29 | 58 | 84725 | 9699 | 29480045 |
Lymphadenectomy | 12.26 | 10.29 | 8 | 84775 | 234 | 29489510 |
Idiosyncratic drug reaction | 12.25 | 10.29 | 10 | 84773 | 416 | 29489328 |
Staphylococcal infection | 12.24 | 10.29 | 133 | 84650 | 29107 | 29460637 |
Lung consolidation | 12.23 | 10.29 | 37 | 84746 | 5006 | 29484738 |
COVID-19 pneumonia | 12.21 | 10.29 | 6 | 84777 | 9516 | 29480228 |
Rash | 12.21 | 10.29 | 663 | 84120 | 189156 | 29300588 |
Corynebacterium infection | 12.13 | 10.29 | 10 | 84773 | 422 | 29489322 |
Skin wrinkling | 12.12 | 10.29 | 9 | 84774 | 325 | 29489419 |
Fear of death | 12.10 | 10.29 | 11 | 84772 | 530 | 29489214 |
Lymphocyte count decreased | 12.10 | 10.29 | 23 | 84760 | 19248 | 29470496 |
Tenderness | 12.04 | 10.29 | 40 | 84743 | 5687 | 29484057 |
Bacterial disease carrier | 12.03 | 10.29 | 10 | 84773 | 427 | 29489317 |
Kounis syndrome | 12.02 | 10.29 | 20 | 84763 | 1809 | 29487935 |
Carditis | 11.99 | 10.29 | 6 | 84777 | 104 | 29489640 |
Gastrooesophageal reflux disease | 11.97 | 10.29 | 48 | 84735 | 31448 | 29458296 |
Hyperglycaemia | 11.96 | 10.29 | 54 | 84729 | 34233 | 29455511 |
Osteonecrosis of jaw | 11.93 | 10.29 | 18 | 84765 | 16492 | 29473252 |
Expanded disability status scale score increased | 11.87 | 10.29 | 8 | 84775 | 247 | 29489497 |
Pulmonary hypertension | 11.86 | 10.29 | 22 | 84761 | 18586 | 29471158 |
Breast inflammation | 11.86 | 10.29 | 4 | 84779 | 23 | 29489721 |
Dyspnoea exertional | 11.83 | 10.29 | 59 | 84724 | 36431 | 29453313 |
Poisoning | 11.79 | 10.29 | 7 | 84776 | 9986 | 29479758 |
Influenza | 11.78 | 10.29 | 71 | 84712 | 41810 | 29447934 |
Psoas abscess | 11.76 | 10.29 | 11 | 84772 | 550 | 29489194 |
Jaundice | 11.68 | 10.29 | 132 | 84651 | 29164 | 29460580 |
Fluid retention | 11.64 | 10.29 | 32 | 84751 | 23528 | 29466216 |
Retinopathy hypertensive | 11.59 | 10.29 | 8 | 84775 | 257 | 29489487 |
Prothrombin time shortened | 11.57 | 10.29 | 17 | 84766 | 1381 | 29488363 |
Hypotension | 11.54 | 10.29 | 448 | 84335 | 193906 | 29295838 |
Herpes zoster meningoencephalitis | 11.43 | 10.29 | 8 | 84775 | 263 | 29489481 |
Hepatic amoebiasis | 11.42 | 10.29 | 5 | 84778 | 63 | 29489681 |
Bladder spasm | 11.42 | 10.29 | 13 | 84770 | 820 | 29488924 |
Stenotrophomonas test positive | 11.38 | 10.29 | 8 | 84775 | 265 | 29489479 |
Cataract subcapsular | 11.37 | 10.29 | 9 | 84774 | 358 | 29489386 |
Pudendal canal syndrome | 11.29 | 10.29 | 3 | 84780 | 6 | 29489738 |
Skin injury | 11.29 | 10.29 | 15 | 84768 | 1109 | 29488635 |
Drain placement | 11.28 | 10.29 | 5 | 84778 | 65 | 29489679 |
Bladder pain | 11.25 | 10.29 | 10 | 84773 | 468 | 29489276 |
Loss of proprioception | 11.22 | 10.29 | 9 | 84774 | 365 | 29489379 |
Hyperinsulinaemia | 11.21 | 10.29 | 5 | 84778 | 66 | 29489678 |
Cardiogenic shock | 11.11 | 10.29 | 24 | 84759 | 19166 | 29470578 |
Eye excision | 11.07 | 10.29 | 4 | 84779 | 29 | 29489715 |
Stomatococcal infection | 11.05 | 10.29 | 6 | 84777 | 124 | 29489620 |
Yawning | 11.03 | 10.29 | 10 | 84773 | 480 | 29489264 |
Lung neoplasm malignant | 11.02 | 10.29 | 15 | 84768 | 14342 | 29475402 |
Polyneuropathy | 11.02 | 10.29 | 66 | 84717 | 12086 | 29477658 |
Hypersensitivity vasculitis | 11.01 | 10.29 | 27 | 84756 | 3230 | 29486514 |
Ejection fraction decreased | 11.00 | 10.29 | 18 | 84765 | 15960 | 29473784 |
Arteriosclerosis | 10.99 | 10.29 | 8 | 84775 | 10248 | 29479496 |
Microbiology test abnormal | 10.98 | 10.29 | 3 | 84780 | 7 | 29489737 |
Blood catecholamines decreased | 10.98 | 10.29 | 3 | 84780 | 7 | 29489737 |
Glutathione decreased | 10.98 | 10.29 | 3 | 84780 | 7 | 29489737 |
Angina unstable | 10.98 | 10.29 | 9 | 84774 | 10856 | 29478888 |
Neuropsychiatric symptoms | 10.96 | 10.29 | 10 | 84773 | 484 | 29489260 |
Injection site bruising | 10.96 | 10.29 | 4 | 84779 | 7576 | 29482168 |
Pancreatic enzyme abnormality | 10.96 | 10.29 | 4 | 84779 | 30 | 29489714 |
Lactic acidosis | 10.94 | 10.29 | 47 | 84736 | 30200 | 29459544 |
Sensory disturbance | 10.92 | 10.29 | 38 | 84745 | 5531 | 29484213 |
Hyperoxaluria | 10.92 | 10.29 | 6 | 84777 | 127 | 29489617 |
Spontaneous haematoma | 10.91 | 10.29 | 10 | 84773 | 487 | 29489257 |
Panic reaction | 10.90 | 10.29 | 16 | 84767 | 1299 | 29488445 |
Hepatic infarction | 10.90 | 10.29 | 7 | 84776 | 199 | 29489545 |
Resting tremor | 10.87 | 10.29 | 11 | 84772 | 606 | 29489138 |
Hypothyroidism | 10.87 | 10.29 | 18 | 84765 | 15888 | 29473856 |
Gynaecomastia | 10.81 | 10.29 | 5 | 84778 | 8212 | 29481532 |
Alcohol intolerance | 10.79 | 10.29 | 9 | 84774 | 386 | 29489358 |
Meningitis | 10.74 | 10.29 | 32 | 84751 | 4293 | 29485451 |
Walking disability | 10.72 | 10.29 | 12 | 84771 | 743 | 29489001 |
Fungaemia | 10.70 | 10.29 | 21 | 84762 | 2160 | 29487584 |
Product use issue | 10.68 | 10.29 | 207 | 84576 | 51237 | 29438507 |
Electrocardiogram QT prolonged | 10.67 | 10.29 | 154 | 84629 | 35983 | 29453761 |
Hypofibrinogenaemia | 10.66 | 10.29 | 17 | 84766 | 1484 | 29488260 |
Pulmonary arterial hypertension | 10.66 | 10.29 | 4 | 84779 | 7445 | 29482299 |
Left ventricular hypertrophy | 10.65 | 10.29 | 3 | 84780 | 6700 | 29483044 |
Oligoarthritis | 10.64 | 10.29 | 5 | 84778 | 75 | 29489669 |
Purpura non-thrombocytopenic | 10.64 | 10.29 | 5 | 84778 | 75 | 29489669 |
Drug level increased | 10.60 | 10.29 | 91 | 84692 | 18696 | 29471048 |
Glycosylated haemoglobin increased | 10.57 | 10.29 | 7 | 84776 | 9419 | 29480325 |
Groin pain | 10.53 | 10.29 | 34 | 84749 | 4764 | 29484980 |
Vitreous detachment | 10.51 | 10.29 | 12 | 84771 | 759 | 29488985 |
Hepato-lenticular degeneration | 10.44 | 10.29 | 3 | 84780 | 9 | 29489735 |
Cholestasis | 10.42 | 10.29 | 108 | 84675 | 23354 | 29466390 |
Resuscitation | 10.41 | 10.29 | 15 | 84768 | 1197 | 29488547 |
Inguinal mass | 10.41 | 10.29 | 5 | 84778 | 79 | 29489665 |
Haemoglobin decreased | 10.39 | 10.29 | 234 | 84549 | 108141 | 29381603 |
Atrioventricular block complete | 10.35 | 10.29 | 5 | 84778 | 8006 | 29481738 |
Nervous system disorder | 10.34 | 10.29 | 67 | 84716 | 12607 | 29477137 |
Aortic intramural haematoma | 10.32 | 10.29 | 4 | 84779 | 36 | 29489708 |
Flavobacterium infection | 10.30 | 10.29 | 5 | 84778 | 81 | 29489663 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Tendon pain | 1103.91 | 9.61 | 432 | 168895 | 4416 | 64324989 |
Tendonitis | 849.62 | 9.61 | 576 | 168751 | 19706 | 64309699 |
Drug hypersensitivity | 728.00 | 9.61 | 1794 | 167533 | 236021 | 64093384 |
Tendon rupture | 514.41 | 9.61 | 332 | 168995 | 10435 | 64318970 |
Drug reaction with eosinophilia and systemic symptoms | 419.24 | 9.61 | 609 | 168718 | 53608 | 64275797 |
Tendon disorder | 396.30 | 9.61 | 232 | 169095 | 6100 | 64323305 |
Pathogen resistance | 395.97 | 9.61 | 300 | 169027 | 12243 | 64317162 |
Toxic epidermal necrolysis | 351.26 | 9.61 | 460 | 168867 | 36706 | 64292699 |
Drug interaction | 308.45 | 9.61 | 1810 | 167517 | 360273 | 63969132 |
Completed suicide | 267.90 | 9.61 | 127 | 169200 | 224287 | 64105118 |
Tubulointerstitial nephritis | 266.73 | 9.61 | 366 | 168961 | 30543 | 64298862 |
Clostridium difficile colitis | 237.38 | 9.61 | 324 | 169003 | 26899 | 64302506 |
Death | 210.33 | 9.61 | 613 | 168714 | 482092 | 63847313 |
Tendon discomfort | 206.97 | 9.61 | 67 | 169260 | 368 | 64329037 |
Tinnitus | 203.18 | 9.61 | 340 | 168987 | 33793 | 64295612 |
Clostridium difficile infection | 195.28 | 9.61 | 345 | 168982 | 35818 | 64293587 |
Rheumatoid arthritis | 185.48 | 9.61 | 100 | 169227 | 164194 | 64165211 |
Drug abuse | 184.14 | 9.61 | 59 | 169268 | 132315 | 64197090 |
Drug resistance | 179.47 | 9.61 | 327 | 169000 | 34775 | 64294630 |
Myalgia | 179.26 | 9.61 | 858 | 168469 | 157759 | 64171646 |
Paraesthesia | 160.26 | 9.61 | 739 | 168588 | 133783 | 64195622 |
Stevens-Johnson syndrome | 157.60 | 9.61 | 305 | 169022 | 33944 | 64295461 |
Hand deformity | 149.85 | 9.61 | 3 | 169324 | 62768 | 64266637 |
Synovitis | 149.19 | 9.61 | 38 | 169289 | 99052 | 64230353 |
Fall | 142.45 | 9.61 | 587 | 168740 | 416239 | 63913166 |
Pemphigus | 133.75 | 9.61 | 6 | 169321 | 60695 | 64268710 |
Acute kidney injury | 132.32 | 9.61 | 1778 | 167549 | 447462 | 63881943 |
Joint noise | 131.57 | 9.61 | 90 | 169237 | 3121 | 64326284 |
Intentional overdose | 128.83 | 9.61 | 38 | 169289 | 89906 | 64239499 |
Dysbiosis | 127.12 | 9.61 | 57 | 169270 | 838 | 64328567 |
Anti-cyclic citrullinated peptide antibody positive | 115.85 | 9.61 | 3 | 169324 | 49559 | 64279846 |
Panic attack | 115.83 | 9.61 | 202 | 169125 | 20751 | 64308654 |
Rash maculo-papular | 104.56 | 9.61 | 316 | 169011 | 46710 | 64282695 |
Anxiety | 102.95 | 9.61 | 895 | 168432 | 201754 | 64127651 |
Torsade de pointes | 102.04 | 9.61 | 172 | 169155 | 17191 | 64312214 |
Injection site pain | 100.12 | 9.61 | 87 | 169240 | 111321 | 64218084 |
Toxicity to various agents | 100.06 | 9.61 | 553 | 168774 | 362960 | 63966445 |
Pseudomembranous colitis | 99.66 | 9.61 | 91 | 169236 | 4825 | 64324580 |
Maternal exposure during pregnancy | 98.82 | 9.61 | 65 | 169262 | 95819 | 64233586 |
Infusion related reaction | 98.02 | 9.61 | 176 | 169151 | 164291 | 64165114 |
Hyperacusis | 95.42 | 9.61 | 61 | 169266 | 1884 | 64327521 |
Septic shock | 89.97 | 9.61 | 528 | 168799 | 104909 | 64224496 |
Glossodynia | 89.64 | 9.61 | 29 | 169298 | 64667 | 64264738 |
Fistula | 89.38 | 9.61 | 119 | 169208 | 9642 | 64319763 |
Tendon injury | 88.96 | 9.61 | 56 | 169271 | 1683 | 64327722 |
Choroiditis | 87.53 | 9.61 | 47 | 169280 | 1040 | 64328365 |
Drug intolerance | 86.61 | 9.61 | 232 | 169095 | 187760 | 64141645 |
Impaired work ability | 84.49 | 9.61 | 147 | 169180 | 15072 | 64314333 |
Product dose omission issue | 83.33 | 9.61 | 249 | 169078 | 194498 | 64134907 |
Geotrichum infection | 83.32 | 9.61 | 43 | 169284 | 875 | 64328530 |
Multiple organ dysfunction syndrome | 82.14 | 9.61 | 501 | 168826 | 100912 | 64228493 |
Muscle atrophy | 80.35 | 9.61 | 113 | 169214 | 9645 | 64319760 |
Contraindicated product administered | 80.17 | 9.61 | 99 | 169228 | 107730 | 64221675 |
Therapeutic product effect incomplete | 80.15 | 9.61 | 92 | 169235 | 103390 | 64226015 |
Muscle twitching | 79.94 | 9.61 | 163 | 169164 | 18835 | 64310570 |
Pyrexia | 79.88 | 9.61 | 1974 | 167353 | 556670 | 63772735 |
Rheumatoid factor positive | 78.49 | 9.61 | 3 | 169324 | 34935 | 64294470 |
Nasopharyngitis | 77.36 | 9.61 | 260 | 169067 | 195813 | 64133592 |
Arthropathy | 77.07 | 9.61 | 124 | 169203 | 120843 | 64208562 |
Pericarditis | 76.65 | 9.61 | 34 | 169293 | 62482 | 64266923 |
Early retirement | 74.79 | 9.61 | 16 | 169311 | 5 | 64329400 |
Duodenal ulcer perforation | 74.43 | 9.61 | 4 | 169323 | 34621 | 64294784 |
Candida infection | 73.51 | 9.61 | 215 | 169112 | 31204 | 64298201 |
Suicide attempt | 73.35 | 9.61 | 48 | 169279 | 70959 | 64258446 |
Burning sensation | 73.09 | 9.61 | 291 | 169036 | 49373 | 64280032 |
Neuropathy peripheral | 70.95 | 9.61 | 540 | 168787 | 116985 | 64212420 |
Connective tissue disorder | 70.60 | 9.61 | 41 | 169286 | 1061 | 64328344 |
Weight increased | 70.52 | 9.61 | 304 | 169023 | 213044 | 64116361 |
Pseudomonas infection | 68.91 | 9.61 | 148 | 169179 | 17735 | 64311670 |
Factor V inhibition | 68.06 | 9.61 | 28 | 169299 | 329 | 64329076 |
Abdominal pain | 67.29 | 9.61 | 1173 | 168154 | 311202 | 64018203 |
Photosensitivity reaction | 67.29 | 9.61 | 148 | 169179 | 18025 | 64311380 |
Helicobacter infection | 65.38 | 9.61 | 11 | 169316 | 38351 | 64291054 |
Wound | 64.81 | 9.61 | 63 | 169264 | 76414 | 64252991 |
Neuralgia | 63.99 | 9.61 | 182 | 169145 | 26002 | 64303403 |
Myocardial infarction | 63.96 | 9.61 | 222 | 169105 | 165599 | 64163806 |
Linear IgA disease | 63.49 | 9.61 | 55 | 169272 | 2719 | 64326686 |
Systemic lupus erythematosus | 63.41 | 9.61 | 66 | 169261 | 77546 | 64251859 |
Eosinophilia | 63.35 | 9.61 | 232 | 169095 | 37844 | 64291561 |
Food intolerance | 62.61 | 9.61 | 55 | 169272 | 2771 | 64326634 |
Cardiac failure congestive | 62.53 | 9.61 | 158 | 169169 | 130422 | 64198983 |
Eye pain | 62.46 | 9.61 | 204 | 169123 | 31421 | 64297984 |
Therapeutic product effect decreased | 62.14 | 9.61 | 131 | 169196 | 115220 | 64214185 |
Acute generalised exanthematous pustulosis | 62.00 | 9.61 | 123 | 169204 | 13935 | 64315470 |
Wrong technique in product usage process | 60.50 | 9.61 | 49 | 169278 | 64925 | 64264480 |
Coma | 59.47 | 9.61 | 86 | 169241 | 87529 | 64241876 |
Injection site erythema | 59.21 | 9.61 | 59 | 169268 | 70741 | 64258664 |
Clostridium test positive | 58.90 | 9.61 | 63 | 169264 | 4052 | 64325353 |
Dermatitis exfoliative | 56.18 | 9.61 | 99 | 169228 | 10253 | 64319152 |
Anal abscess | 56.05 | 9.61 | 83 | 169244 | 7425 | 64321980 |
Dysplastic naevus | 55.50 | 9.61 | 27 | 169300 | 482 | 64328923 |
Cerebrovascular accident | 55.23 | 9.61 | 181 | 169146 | 137402 | 64192003 |
Colitis | 54.75 | 9.61 | 301 | 169026 | 58373 | 64271032 |
Pruritus genital | 54.72 | 9.61 | 34 | 169293 | 998 | 64328407 |
Disturbance in attention | 54.40 | 9.61 | 233 | 169094 | 40841 | 64288564 |
Renal tubular necrosis | 54.34 | 9.61 | 154 | 169173 | 21956 | 64307449 |
Hepatic enzyme increased | 54.23 | 9.61 | 168 | 169159 | 129775 | 64199630 |
Aspergillus infection | 53.56 | 9.61 | 127 | 169200 | 16252 | 64313153 |
Overdose | 53.55 | 9.61 | 226 | 169101 | 159340 | 64170065 |
Hyperfibrinolysis | 52.23 | 9.61 | 13 | 169314 | 20 | 64329385 |
Osteoporosis | 51.40 | 9.61 | 23 | 169304 | 42057 | 64287348 |
Anal fistula | 51.13 | 9.61 | 66 | 169261 | 5187 | 64324218 |
Injection site swelling | 49.89 | 9.61 | 23 | 169304 | 41330 | 64288075 |
Cardio-respiratory arrest | 49.50 | 9.61 | 116 | 169211 | 98277 | 64231128 |
Psoriatic arthropathy | 49.30 | 9.61 | 26 | 169301 | 43255 | 64286150 |
Weight bearing difficulty | 48.96 | 9.61 | 47 | 169280 | 2656 | 64326749 |
Injection site reaction | 48.93 | 9.61 | 31 | 169296 | 46633 | 64282772 |
Solar lentigo | 48.79 | 9.61 | 30 | 169297 | 864 | 64328541 |
Hepatitis cholestatic | 48.45 | 9.61 | 102 | 169225 | 12053 | 64317352 |
Vitreous floaters | 48.37 | 9.61 | 71 | 169256 | 6302 | 64323103 |
Febrile neutropenia | 48.32 | 9.61 | 726 | 168601 | 186931 | 64142474 |
Infective pulmonary exacerbation of cystic fibrosis | 48.20 | 9.61 | 100 | 169227 | 11696 | 64317709 |
Anal fissure | 48.02 | 9.61 | 62 | 169265 | 4874 | 64324531 |
Fixed eruption | 47.79 | 9.61 | 42 | 169285 | 2117 | 64327288 |
Cholecystitis chronic | 46.80 | 9.61 | 86 | 169241 | 9201 | 64320204 |
Joint swelling | 46.74 | 9.61 | 352 | 168975 | 215030 | 64114375 |
Photodermatosis | 46.35 | 9.61 | 29 | 169298 | 862 | 64328543 |
Trimethylaminuria | 46.23 | 9.61 | 17 | 169310 | 144 | 64329261 |
Muscle rupture | 45.82 | 9.61 | 49 | 169278 | 3151 | 64326254 |
Therapeutic response decreased | 45.38 | 9.61 | 42 | 169285 | 52146 | 64277259 |
Musculoskeletal injury | 45.13 | 9.61 | 17 | 169310 | 155 | 64329250 |
Acute myocardial infarction | 44.83 | 9.61 | 71 | 169256 | 69647 | 64259758 |
Sphingomonas paucimobilis infection | 44.81 | 9.61 | 15 | 169312 | 93 | 64329312 |
Cystic fibrosis | 44.68 | 9.61 | 50 | 169277 | 3384 | 64326021 |
Malignant neoplasm progression | 44.26 | 9.61 | 150 | 169177 | 112721 | 64216684 |
Rectal abscess | 44.25 | 9.61 | 35 | 169292 | 1522 | 64327883 |
Infective aneurysm | 44.23 | 9.61 | 28 | 169299 | 850 | 64328555 |
Nephritis allergic | 43.89 | 9.61 | 25 | 169302 | 623 | 64328782 |
Peripheral swelling | 43.88 | 9.61 | 345 | 168982 | 208808 | 64120597 |
Megacolon | 43.79 | 9.61 | 47 | 169280 | 3035 | 64326370 |
Skin candida | 43.57 | 9.61 | 36 | 169291 | 1667 | 64327738 |
Intentional product misuse | 43.37 | 9.61 | 77 | 169250 | 72218 | 64257187 |
Alopecia | 43.36 | 9.61 | 256 | 169071 | 165434 | 64163971 |
Psoriasis | 43.35 | 9.61 | 76 | 169251 | 71627 | 64257778 |
Hypertension | 42.14 | 9.61 | 456 | 168871 | 258805 | 64070600 |
Escherichia infection | 41.61 | 9.61 | 110 | 169217 | 15058 | 64314347 |
COVID-19 | 41.26 | 9.61 | 67 | 169260 | 65073 | 64264332 |
Bradycardia | 41.18 | 9.61 | 165 | 169162 | 118054 | 64211351 |
Henoch-Schonlein purpura | 41.18 | 9.61 | 39 | 169288 | 2167 | 64327238 |
Exposure during pregnancy | 41.17 | 9.61 | 89 | 169238 | 77586 | 64251819 |
Enterococcal infection | 40.55 | 9.61 | 103 | 169224 | 13763 | 64315642 |
Asthma | 40.52 | 9.61 | 122 | 169205 | 95103 | 64234302 |
Cross sensitivity reaction | 40.38 | 9.61 | 47 | 169280 | 3320 | 64326085 |
Rash morbilliform | 40.07 | 9.61 | 58 | 169269 | 5083 | 64324322 |
Injection site bruising | 39.76 | 9.61 | 23 | 169304 | 36350 | 64293055 |
Sinusitis | 39.51 | 9.61 | 223 | 169104 | 145705 | 64183700 |
Spinal muscular atrophy | 39.46 | 9.61 | 18 | 169309 | 276 | 64329129 |
Sensory processing disorder | 39.35 | 9.61 | 9 | 169318 | 7 | 64329398 |
Dermatitis bullous | 38.91 | 9.61 | 93 | 169234 | 11961 | 64317444 |
Leukocytosis | 38.89 | 9.61 | 199 | 169128 | 37541 | 64291864 |
Accidental exposure to product | 37.99 | 9.61 | 11 | 169316 | 26353 | 64303052 |
Penis injury | 37.52 | 9.61 | 14 | 169313 | 124 | 64329281 |
Segmental diverticular colitis | 37.43 | 9.61 | 14 | 169313 | 125 | 64329280 |
Product administration error | 37.23 | 9.61 | 13 | 169314 | 27630 | 64301775 |
Palpitations | 36.34 | 9.61 | 427 | 168900 | 104061 | 64225344 |
Trichoglossia | 36.23 | 9.61 | 18 | 169309 | 337 | 64329068 |
Acinetobacter infection | 36.21 | 9.61 | 38 | 169289 | 2391 | 64327014 |
Device expulsion | 36.15 | 9.61 | 6 | 169321 | 21130 | 64308275 |
Hypoaesthesia | 36.11 | 9.61 | 539 | 168788 | 138569 | 64190836 |
Pouchitis | 35.92 | 9.61 | 24 | 169303 | 800 | 64328605 |
Osteonecrosis of jaw | 35.88 | 9.61 | 31 | 169296 | 39794 | 64289611 |
Pedal pulse abnormal | 35.60 | 9.61 | 14 | 169313 | 145 | 64329260 |
Ligament pain | 35.60 | 9.61 | 15 | 169312 | 188 | 64329217 |
Muscle contractions involuntary | 35.43 | 9.61 | 43 | 169284 | 3174 | 64326231 |
Drug ineffective | 35.01 | 9.61 | 1827 | 167500 | 838420 | 63490985 |
Plantar fasciitis | 34.89 | 9.61 | 40 | 169287 | 2780 | 64326625 |
Discomfort | 34.85 | 9.61 | 103 | 169224 | 80775 | 64248630 |
Abnormal palmar/plantar creases | 34.62 | 9.61 | 7 | 169320 | 0 | 64329405 |
Nervous system disorder | 34.57 | 9.61 | 136 | 169191 | 22942 | 64306463 |
Visual impairment | 34.39 | 9.61 | 321 | 169006 | 73756 | 64255649 |
Folliculitis | 34.36 | 9.61 | 18 | 169309 | 30059 | 64299346 |
Thrombocytopenia | 34.30 | 9.61 | 799 | 168528 | 223002 | 64106403 |
Total lung capacity increased | 34.23 | 9.61 | 22 | 169305 | 686 | 64328719 |
Diastasis recti abdominis | 34.03 | 9.61 | 9 | 169318 | 20 | 64329385 |
Hyphaema | 33.27 | 9.61 | 21 | 169306 | 634 | 64328771 |
Injury | 33.05 | 9.61 | 256 | 169071 | 55736 | 64273669 |
Product substitution issue | 33.05 | 9.61 | 4 | 169323 | 17857 | 64311548 |
Loss of employment | 32.37 | 9.61 | 32 | 169295 | 1875 | 64327530 |
Pulmonary arterial hypertension | 32.37 | 9.61 | 13 | 169314 | 25354 | 64304051 |
Aortic valve prolapse | 32.26 | 9.61 | 8 | 169319 | 12 | 64329393 |
Drug-induced liver injury | 32.22 | 9.61 | 225 | 169102 | 47418 | 64281987 |
Yellow fever | 32.13 | 9.61 | 7 | 169320 | 3 | 64329402 |
Muscle tightness | 31.91 | 9.61 | 82 | 169245 | 11033 | 64318372 |
Emotional distress | 31.71 | 9.61 | 182 | 169145 | 35856 | 64293549 |
Intraocular pressure increased | 31.17 | 9.61 | 68 | 169259 | 8234 | 64321171 |
Hallucination | 31.12 | 9.61 | 310 | 169017 | 72478 | 64256927 |
Stomatitis | 31.03 | 9.61 | 165 | 169162 | 109440 | 64219965 |
Diarrhoea | 30.95 | 9.61 | 2248 | 167079 | 720456 | 63608949 |
Factor V deficiency | 30.79 | 9.61 | 11 | 169316 | 85 | 64329320 |
Abscess | 30.75 | 9.61 | 116 | 169211 | 19188 | 64310217 |
Vanishing bile duct syndrome | 30.61 | 9.61 | 26 | 169301 | 1251 | 64328154 |
Bladder pain | 30.44 | 9.61 | 30 | 169297 | 1751 | 64327654 |
Nerve injury | 30.06 | 9.61 | 64 | 169263 | 7621 | 64321784 |
Chronic fatigue syndrome | 30.03 | 9.61 | 25 | 169302 | 1170 | 64328235 |
Neutropenia | 29.81 | 9.61 | 832 | 168495 | 238792 | 64090613 |
Undersensing | 29.78 | 9.61 | 7 | 169320 | 7 | 64329398 |
Polyneuropathy | 29.61 | 9.61 | 117 | 169210 | 19777 | 64309628 |
Red blood cell sedimentation rate abnormal | 29.33 | 9.61 | 4 | 169323 | 16302 | 64313103 |
Klebsiella infection | 29.28 | 9.61 | 89 | 169238 | 13192 | 64316213 |
Treatment failure | 29.24 | 9.61 | 183 | 169144 | 116633 | 64212772 |
Sepsis | 29.00 | 9.61 | 801 | 168526 | 229540 | 64099865 |
Off label use | 28.81 | 9.61 | 1363 | 167964 | 631443 | 63697962 |
Haematospermia | 28.77 | 9.61 | 14 | 169313 | 250 | 64329155 |
Depressed level of consciousness | 28.77 | 9.61 | 113 | 169214 | 81323 | 64248082 |
Dysuria | 28.66 | 9.61 | 199 | 169128 | 41858 | 64287547 |
Procedural anxiety | 28.53 | 9.61 | 19 | 169308 | 630 | 64328775 |
Muscle injury | 28.50 | 9.61 | 17 | 169310 | 26420 | 64302985 |
Fungaemia | 28.48 | 9.61 | 42 | 169285 | 3743 | 64325662 |
Toxic skin eruption | 28.37 | 9.61 | 113 | 169214 | 19171 | 64310234 |
Poisoning | 28.26 | 9.61 | 11 | 169316 | 21868 | 64307537 |
Vulvovaginal burning sensation | 28.25 | 9.61 | 24 | 169303 | 1155 | 64328250 |
Muscular weakness | 28.00 | 9.61 | 480 | 168847 | 126858 | 64202547 |
Cardiac failure | 27.91 | 9.61 | 218 | 169109 | 132155 | 64197250 |
Pregnancy | 27.78 | 9.61 | 10 | 169317 | 20855 | 64308550 |
Anorectal ulcer | 27.72 | 9.61 | 9 | 169318 | 50 | 64329355 |
Non-consummation | 27.72 | 9.61 | 9 | 169318 | 50 | 64329355 |
Diabetes mellitus | 27.68 | 9.61 | 86 | 169241 | 66388 | 64263017 |
Penile haemorrhage | 27.64 | 9.61 | 17 | 169310 | 490 | 64328915 |
Abdominal abscess | 27.61 | 9.61 | 55 | 169272 | 6249 | 64323156 |
Dyspnoea | 27.41 | 9.61 | 1576 | 167751 | 717098 | 63612307 |
Multiple sclerosis relapse | 27.30 | 9.61 | 41 | 169286 | 41094 | 64288311 |
Hypotony of eye | 27.29 | 9.61 | 13 | 169314 | 221 | 64329184 |
Motor neurone disease | 27.24 | 9.61 | 16 | 169311 | 423 | 64328982 |
Flushing | 27.24 | 9.61 | 110 | 169217 | 78538 | 64250867 |
Corneal opacity | 27.14 | 9.61 | 21 | 169306 | 884 | 64328521 |
Prostatitis | 27.11 | 9.61 | 40 | 169287 | 3566 | 64325839 |
Blood glucose increased | 27.01 | 9.61 | 149 | 169178 | 97924 | 64231481 |
Depersonalisation/derealisation disorder | 26.88 | 9.61 | 27 | 169300 | 1613 | 64327792 |
Impaired healing | 26.79 | 9.61 | 76 | 169251 | 60397 | 64269008 |
Moraxella test positive | 26.64 | 9.61 | 7 | 169320 | 15 | 64329390 |
Lymphocyte count decreased | 26.59 | 9.61 | 41 | 169286 | 40658 | 64288747 |
Diverticulitis | 26.48 | 9.61 | 183 | 169144 | 38435 | 64290970 |
Lung consolidation | 26.29 | 9.61 | 61 | 169266 | 7697 | 64321708 |
Oliguria | 26.11 | 9.61 | 91 | 169236 | 14485 | 64314920 |
Urinary tract infection | 26.03 | 9.61 | 794 | 168533 | 230802 | 64098603 |
Sensory disturbance | 25.90 | 9.61 | 85 | 169242 | 13123 | 64316282 |
Hypotension | 25.88 | 9.61 | 782 | 168545 | 380192 | 63949213 |
Mineral deficiency | 25.84 | 9.61 | 8 | 169319 | 37 | 64329368 |
Pulmonary hypertension | 25.82 | 9.61 | 46 | 169281 | 43093 | 64286312 |
Injection site pruritus | 25.79 | 9.61 | 37 | 169290 | 37789 | 64291616 |
Staphylococcal infection | 25.77 | 9.61 | 224 | 169103 | 50454 | 64278951 |
Intentional self-injury | 25.69 | 9.61 | 23 | 169304 | 29021 | 64300384 |
Pudendal canal syndrome | 25.53 | 9.61 | 6 | 169321 | 6 | 64329399 |
Night sweats | 25.42 | 9.61 | 172 | 169155 | 35874 | 64293531 |
Rash | 25.32 | 9.61 | 1458 | 167869 | 457091 | 63872314 |
Trichosporon infection | 25.24 | 9.61 | 20 | 169307 | 872 | 64328533 |
Abscess intestinal | 25.11 | 9.61 | 31 | 169296 | 2329 | 64327076 |
Cholestatic liver injury | 25.10 | 9.61 | 39 | 169288 | 3640 | 64325765 |
Incorrect route of product administration | 25.09 | 9.61 | 15 | 169312 | 23283 | 64306122 |
Increased bronchial secretion | 25.03 | 9.61 | 34 | 169293 | 2808 | 64326597 |
Diabetic ketoacidosis | 24.80 | 9.61 | 25 | 169302 | 29820 | 64299585 |
Toxic encephalopathy | 24.74 | 9.61 | 69 | 169258 | 9746 | 64319659 |
Yellow fever vaccine-associated viscerotropic disease | 24.73 | 9.61 | 5 | 169322 | 0 | 64329405 |
Ectropion | 24.61 | 9.61 | 14 | 169313 | 348 | 64329057 |
Urosepsis | 24.53 | 9.61 | 119 | 169208 | 21975 | 64307430 |
Sopor | 24.47 | 9.61 | 25 | 169302 | 29636 | 64299769 |
Acute hepatic failure | 24.38 | 9.61 | 134 | 169193 | 25978 | 64303427 |
Right ventricular failure | 24.30 | 9.61 | 13 | 169314 | 21458 | 64307947 |
Calcium ionised decreased | 24.25 | 9.61 | 16 | 169311 | 522 | 64328883 |
Osteonecrosis | 24.21 | 9.61 | 23 | 169304 | 28206 | 64301199 |
Sputum increased | 24.05 | 9.61 | 38 | 169289 | 3597 | 64325808 |
Ependymoma | 23.98 | 9.61 | 8 | 169319 | 49 | 64329356 |
Catatonia | 23.75 | 9.61 | 58 | 169269 | 7562 | 64321843 |
Transmission of an infectious agent via product | 23.64 | 9.61 | 11 | 169316 | 177 | 64329228 |
Mitochondrial cytopathy | 23.54 | 9.61 | 14 | 169313 | 379 | 64329026 |
Septic embolus | 23.52 | 9.61 | 26 | 169301 | 1736 | 64327669 |
Contusion | 23.41 | 9.61 | 189 | 169138 | 113776 | 64215629 |
Drug dependence | 23.29 | 9.61 | 32 | 169295 | 33280 | 64296125 |
Lower respiratory tract infection bacterial | 23.23 | 9.61 | 17 | 169310 | 657 | 64328748 |
Depression | 23.23 | 9.61 | 638 | 168689 | 182653 | 64146752 |
Rash erythematous | 23.20 | 9.61 | 212 | 169115 | 48421 | 64280984 |
Cutaneous vasculitis | 23.16 | 9.61 | 52 | 169275 | 6421 | 64322984 |
Flank pain | 23.12 | 9.61 | 94 | 169233 | 16095 | 64313310 |
Pulmonary eosinophilia | 23.11 | 9.61 | 16 | 169311 | 566 | 64328839 |
Orchitis | 23.10 | 9.61 | 21 | 169306 | 1107 | 64328298 |
Bacterial colitis | 23.07 | 9.61 | 9 | 169318 | 91 | 64329314 |
Cardiac arrest | 23.04 | 9.61 | 276 | 169051 | 153788 | 64175617 |
Phlebitis | 23.03 | 9.61 | 58 | 169269 | 7708 | 64321697 |
Somnolence | 22.96 | 9.61 | 386 | 168941 | 203259 | 64126146 |
Aortic aneurysm | 22.92 | 9.61 | 57 | 169270 | 7517 | 64321888 |
Clostridial infection | 22.83 | 9.61 | 45 | 169282 | 5074 | 64324331 |
Chest injury | 22.80 | 9.61 | 30 | 169297 | 2403 | 64327002 |
Headache | 22.78 | 9.61 | 1147 | 168180 | 528320 | 63801085 |
Potentiating drug interaction | 22.62 | 9.61 | 58 | 169269 | 7794 | 64321611 |
Coronary artery disease | 22.55 | 9.61 | 82 | 169245 | 60351 | 64269054 |
Thrombotic thrombocytopenic purpura | 22.45 | 9.61 | 49 | 169278 | 5935 | 64323470 |
Respiratory tract infection bacterial | 22.32 | 9.61 | 18 | 169309 | 805 | 64328600 |
Escherichia urinary tract infection | 22.30 | 9.61 | 76 | 169251 | 11961 | 64317444 |
Lumbosacral plexus injury | 22.19 | 9.61 | 6 | 169321 | 15 | 64329390 |
Hyperkalaemia | 22.04 | 9.61 | 165 | 169162 | 100964 | 64228441 |
Oesophageal spasm | 21.92 | 9.61 | 30 | 169297 | 2495 | 64326910 |
Nosocomial infection | 21.81 | 9.61 | 30 | 169297 | 2507 | 64326898 |
Fracture | 21.76 | 9.61 | 11 | 169316 | 18744 | 64310661 |
Femur fracture | 21.72 | 9.61 | 35 | 169292 | 34100 | 64295305 |
Incorrect dose administered | 21.67 | 9.61 | 84 | 169243 | 60681 | 64268724 |
Skin burning sensation | 21.56 | 9.61 | 69 | 169258 | 10514 | 64318891 |
Confabulation | 21.54 | 9.61 | 14 | 169313 | 445 | 64328960 |
Type 2 diabetes mellitus | 21.53 | 9.61 | 35 | 169292 | 33985 | 64295420 |
Diaphragmatic rupture | 21.49 | 9.61 | 11 | 169316 | 220 | 64329185 |
Corneal deposits | 21.47 | 9.61 | 13 | 169314 | 364 | 64329041 |
Herpes zoster | 21.42 | 9.61 | 121 | 169206 | 79066 | 64250339 |
Tendon necrosis | 21.27 | 9.61 | 5 | 169322 | 5 | 64329400 |
Inappropriate antidiuretic hormone secretion | 21.22 | 9.61 | 115 | 169212 | 22174 | 64307231 |
Ischaemic stroke | 21.21 | 9.61 | 27 | 169300 | 29008 | 64300397 |
Feeding intolerance | 21.02 | 9.61 | 15 | 169312 | 557 | 64328848 |
Abdominal pain lower | 20.93 | 9.61 | 130 | 169197 | 26339 | 64303066 |
Neoplasm progression | 20.83 | 9.61 | 48 | 169279 | 40916 | 64288489 |
Auditory disorder | 20.82 | 9.61 | 13 | 169314 | 385 | 64329020 |
Walking disability | 20.81 | 9.61 | 25 | 169302 | 1826 | 64327579 |
Staphylococcal scalded skin syndrome | 20.76 | 9.61 | 13 | 169314 | 387 | 64329018 |
Tooth disorder | 20.72 | 9.61 | 17 | 169310 | 22385 | 64307020 |
Gastroenteritis pseudomonas | 20.70 | 9.61 | 6 | 169321 | 21 | 64329384 |
Pyelonephritis | 20.63 | 9.61 | 95 | 169232 | 17171 | 64312234 |
Blood pressure increased | 20.46 | 9.61 | 324 | 169003 | 172228 | 64157177 |
Cystitis | 20.34 | 9.61 | 186 | 169141 | 42489 | 64286916 |
Haemorrhagic vasculitis | 20.33 | 9.61 | 8 | 169319 | 83 | 64329322 |
Hyperinsulinaemia | 20.28 | 9.61 | 10 | 169317 | 184 | 64329221 |
Ligament disorder | 20.27 | 9.61 | 12 | 169315 | 322 | 64329083 |
C-reactive protein abnormal | 20.21 | 9.61 | 28 | 169299 | 29019 | 64300386 |
Fear of death | 20.21 | 9.61 | 21 | 169306 | 1306 | 64328099 |
Bone marrow granuloma | 20.08 | 9.61 | 6 | 169321 | 24 | 64329381 |
Aortic aneurysm rupture | 20.06 | 9.61 | 20 | 169307 | 1184 | 64328221 |
Aeromonas infection | 20.04 | 9.61 | 12 | 169315 | 329 | 64329076 |
Visual acuity reduced | 20.04 | 9.61 | 131 | 169196 | 27010 | 64302395 |
Meningitis candida | 20.03 | 9.61 | 9 | 169318 | 133 | 64329272 |
Metastases to liver | 19.96 | 9.61 | 20 | 169307 | 23921 | 64305484 |
Influenza | 19.94 | 9.61 | 181 | 169146 | 106350 | 64223055 |
Yellow fever vaccine-associated neurotropic disease | 19.78 | 9.61 | 4 | 169323 | 0 | 64329405 |
Posterior tibial tendon dysfunction | 19.78 | 9.61 | 4 | 169323 | 0 | 64329405 |
Renal vein compression | 19.78 | 9.61 | 4 | 169323 | 0 | 64329405 |
Tendon laxity | 19.78 | 9.61 | 4 | 169323 | 0 | 64329405 |
Respiratory arrest | 19.70 | 9.61 | 72 | 169255 | 52913 | 64276492 |
Limb immobilisation | 19.60 | 9.61 | 7 | 169320 | 54 | 64329351 |
Live birth | 19.57 | 9.61 | 3 | 169324 | 11201 | 64318204 |
Electrocardiogram QT prolonged | 19.51 | 9.61 | 305 | 169022 | 79143 | 64250262 |
Device malfunction | 19.49 | 9.61 | 11 | 169316 | 17622 | 64311783 |
Product quality issue | 19.48 | 9.61 | 30 | 169297 | 29769 | 64299636 |
Breast cancer | 19.39 | 9.61 | 29 | 169298 | 29119 | 64300286 |
Leukocyturia | 19.34 | 9.61 | 22 | 169305 | 1516 | 64327889 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 19.32 | 9.61 | 19 | 169308 | 1106 | 64328299 |
Systemic inflammatory response syndrome | 19.29 | 9.61 | 65 | 169262 | 10170 | 64319235 |
Swelling | 19.28 | 9.61 | 300 | 169027 | 159918 | 64169487 |
Rectal tube insertion | 19.26 | 9.61 | 5 | 169322 | 10 | 64329395 |
Crystal nephropathy | 19.23 | 9.61 | 20 | 169307 | 1245 | 64328160 |
Cholestasis | 19.12 | 9.61 | 191 | 169136 | 44681 | 64284724 |
Inflammatory marker increased | 18.97 | 9.61 | 57 | 169270 | 8394 | 64321011 |
Bladder hypertrophy | 18.93 | 9.61 | 14 | 169313 | 550 | 64328855 |
Chemical burns of eye | 18.93 | 9.61 | 8 | 169319 | 101 | 64329304 |
Dyslexia | 18.92 | 9.61 | 10 | 169317 | 214 | 64329191 |
Drug level increased | 18.89 | 9.61 | 154 | 169173 | 34042 | 64295363 |
Hepatic cytolysis | 18.83 | 9.61 | 80 | 169247 | 13969 | 64315436 |
Haematuria | 18.80 | 9.61 | 242 | 169085 | 60229 | 64269176 |
Hip arthroplasty | 18.78 | 9.61 | 17 | 169310 | 21334 | 64308071 |
Injection site mass | 18.76 | 9.61 | 11 | 169316 | 17259 | 64312146 |
Restlessness | 18.76 | 9.61 | 173 | 169154 | 39612 | 64289793 |
Pneumococcal sepsis | 18.73 | 9.61 | 20 | 169307 | 1284 | 64328121 |
Skin oedema | 18.69 | 9.61 | 21 | 169306 | 1427 | 64327978 |
Panic reaction | 18.69 | 9.61 | 36 | 169291 | 3991 | 64325414 |
Subdural haematoma | 18.58 | 9.61 | 28 | 169299 | 28026 | 64301379 |
Paraesthesia oral | 18.56 | 9.61 | 76 | 169251 | 13055 | 64316350 |
Renal injury | 18.52 | 9.61 | 85 | 169242 | 15344 | 64314061 |
Abdominal discomfort | 18.51 | 9.61 | 352 | 168975 | 181970 | 64147435 |
Necrotising retinitis | 18.35 | 9.61 | 18 | 169309 | 1045 | 64328360 |
Acute febrile neutrophilic dermatosis | 18.27 | 9.61 | 32 | 169295 | 3297 | 64326108 |
Bacteriuria | 18.25 | 9.61 | 17 | 169310 | 925 | 64328480 |
Gastrointestinal scarring | 18.20 | 9.61 | 10 | 169317 | 232 | 64329173 |
Anuria | 18.16 | 9.61 | 98 | 169229 | 18866 | 64310539 |
Cough | 18.16 | 9.61 | 630 | 168697 | 301518 | 64027887 |
Prescribed overdose | 18.10 | 9.61 | 16 | 169311 | 20315 | 64309090 |
Graft versus host disease | 18.01 | 9.61 | 78 | 169249 | 13735 | 64315670 |
Vulvovaginal swelling | 17.98 | 9.61 | 11 | 169316 | 314 | 64329091 |
Small fibre neuropathy | 17.93 | 9.61 | 10 | 169317 | 239 | 64329166 |
Transient ischaemic attack | 17.80 | 9.61 | 58 | 169269 | 44124 | 64285281 |
Sudden death | 17.67 | 9.61 | 16 | 169311 | 20080 | 64309325 |
Myosclerosis | 17.67 | 9.61 | 9 | 169318 | 178 | 64329227 |
Angina pectoris | 17.60 | 9.61 | 60 | 169267 | 45021 | 64284384 |
May-Thurner syndrome | 17.59 | 9.61 | 5 | 169322 | 16 | 64329389 |
Hyperpathia | 17.55 | 9.61 | 4 | 169323 | 3 | 64329402 |
Parosmia | 17.42 | 9.61 | 38 | 169289 | 4602 | 64324803 |
Adverse reaction | 17.40 | 9.61 | 52 | 169275 | 7635 | 64321770 |
Biliary dyskinesia | 17.39 | 9.61 | 26 | 169301 | 2346 | 64327059 |
Deafness bilateral | 17.37 | 9.61 | 23 | 169304 | 1853 | 64327552 |
Myopathy | 17.37 | 9.61 | 92 | 169235 | 17588 | 64311817 |
Vulvovaginal pain | 17.33 | 9.61 | 22 | 169305 | 1700 | 64327705 |
Foot deformity | 17.25 | 9.61 | 11 | 169316 | 16493 | 64312912 |
Adverse event | 17.22 | 9.61 | 50 | 169277 | 39439 | 64289966 |
Stoma closure | 17.18 | 9.61 | 8 | 169319 | 129 | 64329276 |
Cerebral infarction | 17.16 | 9.61 | 53 | 169274 | 40991 | 64288414 |
Gastrointestinal inflammation | 17.06 | 9.61 | 45 | 169282 | 6150 | 64323255 |
Epididymitis | 17.01 | 9.61 | 22 | 169305 | 1732 | 64327673 |
Idiopathic intracranial hypertension | 17.01 | 9.61 | 27 | 169300 | 2566 | 64326839 |
Fat tissue decreased | 16.88 | 9.61 | 7 | 169320 | 84 | 64329321 |
Loss of personal independence in daily activities | 16.86 | 9.61 | 116 | 169211 | 72338 | 64257067 |
Gastroenteritis staphylococcal | 16.84 | 9.61 | 10 | 169317 | 270 | 64329135 |
Anhedonia | 16.81 | 9.61 | 76 | 169251 | 13630 | 64315775 |
Acute psychosis | 16.75 | 9.61 | 33 | 169294 | 3719 | 64325686 |
Jaundice | 16.74 | 9.61 | 198 | 169129 | 48314 | 64281091 |
Visual snow syndrome | 16.73 | 9.61 | 5 | 169322 | 20 | 64329385 |
Anal paraesthesia | 16.73 | 9.61 | 5 | 169322 | 20 | 64329385 |
Diabetic macroangiopathy | 16.64 | 9.61 | 8 | 169319 | 139 | 64329266 |
Dysaesthesia | 16.62 | 9.61 | 39 | 169288 | 4956 | 64324449 |
Idiosyncratic drug reaction | 16.54 | 9.61 | 18 | 169309 | 1181 | 64328224 |
Intestinal stenosis | 16.49 | 9.61 | 30 | 169297 | 3184 | 64326221 |
Oxygen saturation decreased | 16.40 | 9.61 | 191 | 169136 | 106985 | 64222420 |
Rectal tenesmus | 16.38 | 9.61 | 17 | 169310 | 1056 | 64328349 |
Head injury | 16.29 | 9.61 | 39 | 169288 | 32803 | 64296602 |
Injection site hyperaesthesia | 16.20 | 9.61 | 6 | 169321 | 52 | 64329353 |
Oesophageal pain | 16.17 | 9.61 | 30 | 169297 | 3233 | 64326172 |
Intestinal fistula | 16.17 | 9.61 | 18 | 169309 | 1211 | 64328194 |
Ligament rupture | 16.08 | 9.61 | 26 | 169301 | 2510 | 64326895 |
Myoclonus | 16.04 | 9.61 | 117 | 169210 | 25001 | 64304404 |
Pneumonia pseudomonal | 16.01 | 9.61 | 38 | 169289 | 4865 | 64324540 |
Mucosal hyperaemia | 16.00 | 9.61 | 6 | 169321 | 54 | 64329351 |
Arthralgia | 15.95 | 9.61 | 1358 | 167969 | 440902 | 63888503 |
Documented hypersensitivity to administered product | 15.84 | 9.61 | 15 | 169312 | 833 | 64328572 |
Pneumonia aspiration | 15.80 | 9.61 | 91 | 169236 | 59180 | 64270225 |
Pulmonary pain | 15.72 | 9.61 | 26 | 169301 | 2558 | 64326847 |
Retinitis viral | 15.67 | 9.61 | 7 | 169320 | 102 | 64329303 |
Bladder trabeculation | 15.62 | 9.61 | 6 | 169321 | 58 | 64329347 |
Chronic gastrointestinal bleeding | 15.57 | 9.61 | 11 | 169316 | 402 | 64329003 |
Hypersensitivity vasculitis | 15.56 | 9.61 | 46 | 169281 | 6715 | 64322690 |
Sedation complication | 15.52 | 9.61 | 4 | 169323 | 10350 | 64319055 |
Schizophrenia | 15.48 | 9.61 | 5 | 169322 | 11163 | 64318242 |
Product contamination microbial | 15.33 | 9.61 | 15 | 169312 | 868 | 64328537 |
Stomatococcal infection | 15.19 | 9.61 | 9 | 169318 | 242 | 64329163 |
Tongue geographic | 15.18 | 9.61 | 6 | 169321 | 63 | 64329342 |
Female genital tract fistula | 15.18 | 9.61 | 26 | 169301 | 2632 | 64326773 |
Prothrombin time shortened | 15.14 | 9.61 | 27 | 169300 | 2822 | 64326583 |
Knee arthroplasty | 15.09 | 9.61 | 30 | 169297 | 26969 | 64302436 |
Prolapse | 15.09 | 9.61 | 4 | 169323 | 9 | 64329396 |
Neurotransmitter level altered | 15.09 | 9.61 | 4 | 169323 | 9 | 64329396 |
Underdose | 15.05 | 9.61 | 28 | 169299 | 25801 | 64303604 |
Ill-defined disorder | 15.01 | 9.61 | 62 | 169265 | 43990 | 64285415 |
Basal cell carcinoma | 14.99 | 9.61 | 37 | 169290 | 30801 | 64298604 |
Systemic candida | 14.98 | 9.61 | 39 | 169288 | 5290 | 64324115 |
Blood cholesterol increased | 14.94 | 9.61 | 74 | 169253 | 49992 | 64279413 |
Activated partial thromboplastin time prolonged | 14.89 | 9.61 | 70 | 169257 | 12761 | 64316644 |
Hospitalisation | 14.86 | 9.61 | 126 | 169201 | 75081 | 64254324 |
Skin test positive | 14.86 | 9.61 | 16 | 169311 | 1037 | 64328368 |
Intrauterine infection | 14.86 | 9.61 | 6 | 169321 | 67 | 64329338 |
Injection site joint erythema | 14.84 | 9.61 | 3 | 169324 | 0 | 64329405 |
Generalised tonic-clonic seizure | 14.80 | 9.61 | 165 | 169162 | 39692 | 64289713 |
Gluten sensitivity | 14.77 | 9.61 | 10 | 169317 | 341 | 64329064 |
Red blood cell count decreased | 14.73 | 9.61 | 71 | 169256 | 48315 | 64281090 |
Eye infection fungal | 14.70 | 9.61 | 11 | 169316 | 440 | 64328965 |
Spinal fracture | 14.68 | 9.61 | 11 | 169316 | 15163 | 64314242 |
COVID-19 pneumonia | 14.68 | 9.61 | 13 | 169314 | 16491 | 64312914 |
Necrosis | 14.62 | 9.61 | 51 | 169276 | 8120 | 64321285 |
Cataract | 14.60 | 9.61 | 77 | 169250 | 51185 | 64278220 |
Deficiency of bile secretion | 14.55 | 9.61 | 5 | 169322 | 34 | 64329371 |
Atrioventricular block complete | 14.54 | 9.61 | 10 | 169317 | 14408 | 64314997 |
Infrequent bowel movements | 14.53 | 9.61 | 18 | 169309 | 1357 | 64328048 |
Enterovesical fistula | 14.45 | 9.61 | 15 | 169312 | 932 | 64328473 |
Erythema | 14.28 | 9.61 | 614 | 168713 | 186456 | 64142949 |
Proctalgia | 14.24 | 9.61 | 48 | 169279 | 7511 | 64321894 |
Hepatitis infectious mononucleosis | 14.24 | 9.61 | 7 | 169320 | 128 | 64329277 |
Bacteraemia | 14.23 | 9.61 | 120 | 169207 | 26791 | 64302614 |
Histamine intolerance | 14.18 | 9.61 | 5 | 169322 | 37 | 64329368 |
Rash papular | 14.13 | 9.61 | 85 | 169242 | 17028 | 64312377 |
Arrhythmia | 14.06 | 9.61 | 206 | 169121 | 52738 | 64276667 |
Increased viscosity of bronchial secretion | 13.99 | 9.61 | 11 | 169316 | 474 | 64328931 |
Clostridium bacteraemia | 13.99 | 9.61 | 9 | 169318 | 281 | 64329124 |
Staphylococcal sepsis | 13.98 | 9.61 | 69 | 169258 | 12830 | 64316575 |
Pain in extremity | 13.97 | 9.61 | 949 | 168378 | 302136 | 64027269 |
Lip erosion | 13.93 | 9.61 | 17 | 169310 | 1262 | 64328143 |
Rhabdomyolysis | 13.88 | 9.61 | 327 | 169000 | 91399 | 64238006 |
Troponin increased | 13.85 | 9.61 | 12 | 169315 | 15387 | 64314018 |
Groin pain | 13.85 | 9.61 | 63 | 169264 | 11330 | 64318075 |
Endocarditis | 13.83 | 9.61 | 55 | 169272 | 9323 | 64320082 |
Drain placement | 13.81 | 9.61 | 7 | 169320 | 137 | 64329268 |
Multiple-drug resistance | 13.80 | 9.61 | 43 | 169284 | 6459 | 64322946 |
Uveitis | 13.79 | 9.61 | 68 | 169259 | 12640 | 64316765 |
Skin laceration | 13.76 | 9.61 | 27 | 169300 | 24390 | 64305015 |
Post transplant lymphoproliferative disorder | 13.72 | 9.61 | 4 | 169323 | 9540 | 64319865 |
Exercise tolerance decreased | 13.69 | 9.61 | 48 | 169279 | 7662 | 64321743 |
Device issue | 13.69 | 9.61 | 24 | 169303 | 22624 | 64306781 |
Pseudomonal sepsis | 13.67 | 9.61 | 37 | 169290 | 5135 | 64324270 |
Disease progression | 13.63 | 9.61 | 276 | 169051 | 141404 | 64188001 |
Fluid retention | 13.59 | 9.61 | 96 | 169231 | 59510 | 64269895 |
Mobility decreased | 13.51 | 9.61 | 152 | 169175 | 85688 | 64243717 |
Clostridium colitis | 13.51 | 9.61 | 24 | 169303 | 2501 | 64326904 |
Therapy partial responder | 13.49 | 9.61 | 5 | 169322 | 10243 | 64319162 |
Haemorrhage urinary tract | 13.43 | 9.61 | 22 | 169305 | 2147 | 64327258 |
Mucosal inflammation | 13.42 | 9.61 | 235 | 169092 | 62349 | 64267056 |
Face oedema | 13.40 | 9.61 | 111 | 169216 | 24650 | 64304755 |
Peripheral nerve injury | 13.34 | 9.61 | 12 | 169315 | 624 | 64328781 |
Bovine tuberculosis | 13.32 | 9.61 | 7 | 169320 | 148 | 64329257 |
Mouth ulceration | 13.30 | 9.61 | 137 | 169190 | 32307 | 64297098 |
Sitting disability | 13.28 | 9.61 | 7 | 169320 | 149 | 64329256 |
Exfoliative rash | 13.26 | 9.61 | 29 | 169298 | 3517 | 64325888 |
Acid base balance abnormal | 13.26 | 9.61 | 9 | 169318 | 308 | 64329097 |
Gastrointestinal haemorrhage | 13.26 | 9.61 | 256 | 169071 | 132056 | 64197349 |
Seroconversion test positive | 13.24 | 9.61 | 5 | 169322 | 46 | 64329359 |
Psoas abscess | 13.23 | 9.61 | 14 | 169313 | 889 | 64328516 |
Withdrawal syndrome | 13.22 | 9.61 | 26 | 169301 | 23466 | 64305939 |
Faecal volume decreased | 13.20 | 9.61 | 7 | 169320 | 151 | 64329254 |
Faciobrachial dystonic seizure | 13.19 | 9.61 | 4 | 169323 | 17 | 64329388 |
Chronic obstructive pulmonary disease | 13.17 | 9.61 | 121 | 169206 | 70927 | 64258478 |
Abortion spontaneous | 13.16 | 9.61 | 29 | 169298 | 25114 | 64304291 |
Treatment noncompliance | 13.13 | 9.61 | 64 | 169263 | 43418 | 64285987 |
Pyuria | 13.10 | 9.61 | 21 | 169306 | 2012 | 64327393 |
Complex regional pain syndrome | 13.02 | 9.61 | 19 | 169308 | 1677 | 64327728 |
Post infection glomerulonephritis | 13.01 | 9.61 | 4 | 169323 | 18 | 64329387 |
Impaired quality of life | 13.01 | 9.61 | 42 | 169285 | 6429 | 64322976 |
Anxiety disorder | 12.98 | 9.61 | 30 | 169297 | 3775 | 64325630 |
Administration site swelling | 12.96 | 9.61 | 9 | 169318 | 320 | 64329085 |
Myocardial ischaemia | 12.86 | 9.61 | 26 | 169301 | 23225 | 64306180 |
Large intestinal stenosis | 12.83 | 9.61 | 23 | 169304 | 2414 | 64326991 |
Performance status decreased | 12.83 | 9.61 | 37 | 169290 | 5327 | 64324078 |
Angina unstable | 12.80 | 9.61 | 13 | 169314 | 15454 | 64313951 |
Organ failure | 12.79 | 9.61 | 29 | 169298 | 3604 | 64325801 |
Vertebral artery hypoplasia | 12.76 | 9.61 | 3 | 169324 | 3 | 64329402 |
Aeromonas test positive | 12.76 | 9.61 | 3 | 169324 | 3 | 64329402 |
Tachypnoea | 12.76 | 9.61 | 116 | 169211 | 26455 | 64302950 |
Peritoneal adhesions | 12.74 | 9.61 | 9 | 169318 | 329 | 64329076 |
Glare | 12.70 | 9.61 | 6 | 169321 | 100 | 64329305 |
Frequent bowel movements | 12.70 | 9.61 | 87 | 169240 | 18218 | 64311187 |
Sleep disorder due to a general medical condition | 12.69 | 9.61 | 3 | 169324 | 8231 | 64321174 |
Fusarium infection | 12.67 | 9.61 | 18 | 169309 | 1551 | 64327854 |
Throat tightness | 12.63 | 9.61 | 104 | 169223 | 23056 | 64306349 |
Hypophosphataemia | 12.61 | 9.61 | 12 | 169315 | 14708 | 64314697 |
Chest pain | 12.61 | 9.61 | 499 | 168828 | 235481 | 64093924 |
Infusion site streaking | 12.60 | 9.61 | 10 | 169317 | 437 | 64328968 |
Hypercreatininaemia | 12.60 | 9.61 | 13 | 169314 | 802 | 64328603 |
Tonsillar haemorrhage | 12.52 | 9.61 | 8 | 169319 | 247 | 64329158 |
C-reactive protein decreased | 12.48 | 9.61 | 21 | 169306 | 2095 | 64327310 |
Cholecystitis acute | 12.48 | 9.61 | 61 | 169266 | 11299 | 64318106 |
Nervousness | 12.47 | 9.61 | 38 | 169289 | 29518 | 64299887 |
Stenotrophomonas infection | 12.45 | 9.61 | 26 | 169301 | 3054 | 64326351 |
Product complaint | 12.45 | 9.61 | 8 | 169319 | 11946 | 64317459 |
Painful respiration | 12.45 | 9.61 | 26 | 169301 | 3055 | 64326350 |
Neurological symptom | 12.42 | 9.61 | 43 | 169284 | 6821 | 64322584 |
Single functional kidney | 12.39 | 9.61 | 6 | 169321 | 106 | 64329299 |
Organic brain syndrome | 12.39 | 9.61 | 10 | 169317 | 448 | 64328957 |
Corynebacterium infection | 12.37 | 9.61 | 14 | 169313 | 959 | 64328446 |
Pruritus | 12.33 | 9.61 | 966 | 168361 | 311434 | 64017971 |
Agranulocytosis | 12.31 | 9.61 | 154 | 169173 | 38075 | 64291330 |
Stenotrophomonas test positive | 12.25 | 9.61 | 9 | 169318 | 350 | 64329055 |
Cardiac disorder | 12.19 | 9.61 | 91 | 169236 | 55725 | 64273680 |
Colour blindness acquired | 12.14 | 9.61 | 6 | 169321 | 111 | 64329294 |
Penile blister | 12.13 | 9.61 | 5 | 169322 | 59 | 64329346 |
Purple glove syndrome | 12.10 | 9.61 | 8 | 169319 | 262 | 64329143 |
Fistula discharge | 12.06 | 9.61 | 14 | 169313 | 986 | 64328419 |
Anal skin tags | 12.05 | 9.61 | 9 | 169318 | 359 | 64329046 |
Metastases to bone | 12.04 | 9.61 | 22 | 169305 | 20413 | 64308992 |
Vasculitis | 11.96 | 9.61 | 85 | 169242 | 18010 | 64311395 |
Bronchitis | 11.96 | 9.61 | 207 | 169120 | 108536 | 64220869 |
Road traffic accident | 11.95 | 9.61 | 41 | 169286 | 30704 | 64298701 |
Basophil count abnormal | 11.92 | 9.61 | 4 | 169323 | 25 | 64329380 |
Factor XIII Inhibition | 11.92 | 9.61 | 4 | 169323 | 25 | 64329380 |
Hallucinations, mixed | 11.91 | 9.61 | 39 | 169288 | 6013 | 64323392 |
Tongue coated | 11.86 | 9.61 | 15 | 169312 | 1155 | 64328250 |
Pancytopenia | 11.76 | 9.61 | 474 | 168853 | 142835 | 64186570 |
Burning mouth syndrome | 11.72 | 9.61 | 10 | 169317 | 484 | 64328921 |
Joint instability | 11.71 | 9.61 | 16 | 169311 | 1329 | 64328076 |
White blood cell count decreased | 11.70 | 9.61 | 320 | 169007 | 157517 | 64171888 |
Subacute cutaneous lupus erythematosus | 11.61 | 9.61 | 25 | 169302 | 3000 | 64326405 |
Kounis syndrome | 11.61 | 9.61 | 25 | 169302 | 3000 | 64326405 |
Glycosylated haemoglobin increased | 11.59 | 9.61 | 15 | 169312 | 16004 | 64313401 |
Accidental overdose | 11.57 | 9.61 | 47 | 169280 | 33510 | 64295895 |
Haemolytic anaemia | 11.56 | 9.61 | 77 | 169250 | 15976 | 64313429 |
Food allergy | 11.54 | 9.61 | 46 | 169281 | 7805 | 64321600 |
Mitochondrial enzyme deficiency | 11.54 | 9.61 | 4 | 169323 | 28 | 64329377 |
Chromaturia | 11.52 | 9.61 | 100 | 169227 | 22511 | 64306894 |
Urethral pain | 11.45 | 9.61 | 9 | 169318 | 388 | 64329017 |
Product deposit | 11.41 | 9.61 | 9 | 169318 | 390 | 64329015 |
Sedation | 11.41 | 9.61 | 63 | 169264 | 41399 | 64288006 |
Calculus bladder | 11.36 | 9.61 | 15 | 169312 | 1205 | 64328200 |
Enterocutaneous fistula | 11.32 | 9.61 | 17 | 169310 | 1540 | 64327865 |
Anorectal discomfort | 11.26 | 9.61 | 24 | 169303 | 2861 | 64326544 |
Product storage error | 11.25 | 9.61 | 11 | 169316 | 13307 | 64316098 |
Microbiology test abnormal | 11.24 | 9.61 | 3 | 169324 | 7 | 64329398 |
Orchitis noninfective | 11.24 | 9.61 | 3 | 169324 | 7 | 64329398 |
Feeling jittery | 11.24 | 9.61 | 7 | 169320 | 10628 | 64318777 |
Tremor | 11.19 | 9.61 | 486 | 168841 | 147744 | 64181661 |
Hepatic encephalopathy | 11.17 | 9.61 | 94 | 169233 | 20972 | 64308433 |
Miosis | 11.15 | 9.61 | 11 | 169316 | 13255 | 64316150 |
Burnout syndrome | 11.14 | 9.61 | 8 | 169319 | 300 | 64329105 |
Irritability | 11.14 | 9.61 | 54 | 169273 | 36692 | 64292713 |
Cardiac discomfort | 11.10 | 9.61 | 14 | 169313 | 1075 | 64328330 |
Testicular pain | 11.10 | 9.61 | 18 | 169309 | 1742 | 64327663 |
Pelvic fracture | 11.10 | 9.61 | 7 | 169320 | 10556 | 64318849 |
Interstitial lung disease | 11.08 | 9.61 | 185 | 169142 | 97547 | 64231858 |
Vulvovaginal candidiasis | 11.08 | 9.61 | 20 | 169307 | 2110 | 64327295 |
Candida osteomyelitis | 11.08 | 9.61 | 4 | 169323 | 32 | 64329373 |
Hypersensitivity | 11.02 | 9.61 | 413 | 168914 | 196039 | 64133366 |
Pain of skin | 11.02 | 9.61 | 52 | 169275 | 9495 | 64319910 |
Papilloma | 10.98 | 9.61 | 8 | 169319 | 307 | 64329098 |
Roseola | 10.96 | 9.61 | 3 | 169324 | 8 | 64329397 |
Loss of consciousness | 10.94 | 9.61 | 301 | 169026 | 148064 | 64181341 |
Long QT syndrome | 10.92 | 9.61 | 34 | 169293 | 5105 | 64324300 |
Ankylosing spondylitis | 10.87 | 9.61 | 4 | 169323 | 8230 | 64321175 |
Nephropathy toxic | 10.85 | 9.61 | 81 | 169246 | 17433 | 64311972 |
Coeliac disease | 10.85 | 9.61 | 3 | 169324 | 7409 | 64321996 |
Gastrointestinal pain | 10.83 | 9.61 | 44 | 169283 | 7530 | 64321875 |
Hyperchlorhydria | 10.81 | 9.61 | 18 | 169309 | 1781 | 64327624 |
Sense of oppression | 10.81 | 9.61 | 16 | 169311 | 1431 | 64327974 |
Neuropsychiatric symptoms | 10.78 | 9.61 | 13 | 169314 | 953 | 64328452 |
Gastrointestinal infection | 10.77 | 9.61 | 46 | 169281 | 8050 | 64321355 |
Lower respiratory tract infection | 10.76 | 9.61 | 179 | 169148 | 94435 | 64234970 |
Altered state of consciousness | 10.75 | 9.61 | 57 | 169270 | 37845 | 64291560 |
Glomerular filtration rate decreased | 10.72 | 9.61 | 22 | 169305 | 19550 | 64309855 |
Drug ineffective for unapproved indication | 10.71 | 9.61 | 127 | 169200 | 31006 | 64298399 |
Scar excision | 10.67 | 9.61 | 4 | 169323 | 36 | 64329369 |
Herpes zoster meningoencephalitis | 10.65 | 9.61 | 11 | 169316 | 679 | 64328726 |
Neuroleptic malignant syndrome | 10.64 | 9.61 | 32 | 169295 | 24964 | 64304441 |
Overgrowth bacterial | 10.63 | 9.61 | 6 | 169321 | 147 | 64329258 |
Hypoxia | 10.61 | 9.61 | 165 | 169162 | 87984 | 64241421 |
Culture stool positive | 10.60 | 9.61 | 10 | 169317 | 553 | 64328852 |
Inflammation | 10.56 | 9.61 | 235 | 169092 | 65065 | 64264340 |
Cytokine release syndrome | 10.55 | 9.61 | 92 | 169235 | 20737 | 64308668 |
Blood creatine increased | 10.48 | 9.61 | 46 | 169281 | 8146 | 64321259 |
Metatarsal excision | 10.46 | 9.61 | 3 | 169324 | 10 | 64329395 |
Fluorosis | 10.45 | 9.61 | 5 | 169322 | 86 | 64329319 |
Lupus-like syndrome | 10.43 | 9.61 | 5 | 169322 | 8786 | 64320619 |
Progressive multifocal leukoencephalopathy | 10.41 | 9.61 | 20 | 169307 | 18212 | 64311193 |
Left ventricular hypertrophy | 10.41 | 9.61 | 6 | 169321 | 9500 | 64319905 |
Injection site haemorrhage | 10.40 | 9.61 | 31 | 169296 | 24247 | 64305158 |
Perineal pain | 10.39 | 9.61 | 13 | 169314 | 990 | 64328415 |
Renal pain | 10.36 | 9.61 | 41 | 169286 | 6933 | 64322472 |
Lactic acidosis | 10.36 | 9.61 | 107 | 169220 | 61303 | 64268102 |
Inappropriate schedule of product administration | 10.36 | 9.61 | 175 | 169152 | 92111 | 64237294 |
Petechiae | 10.35 | 9.61 | 84 | 169243 | 18542 | 64310863 |
Rebound acid hypersecretion | 10.34 | 9.61 | 5 | 169322 | 88 | 64329317 |
Therapeutic response unexpected | 10.29 | 9.61 | 18 | 169309 | 16983 | 64312422 |
Anal inflammation | 10.23 | 9.61 | 9 | 169318 | 454 | 64328951 |
Intestinal dilatation | 10.21 | 9.61 | 20 | 169307 | 2244 | 64327161 |
Prostatic disorder | 10.21 | 9.61 | 17 | 169310 | 1682 | 64327723 |
Tongue disorder | 10.17 | 9.61 | 10 | 169317 | 12070 | 64317335 |
Cholelithiasis | 10.16 | 9.61 | 172 | 169155 | 45334 | 64284071 |
Skin exfoliation | 10.15 | 9.61 | 170 | 169157 | 44715 | 64284690 |
Flavobacterium infection | 10.14 | 9.61 | 5 | 169322 | 92 | 64329313 |
Infusion site reaction | 10.11 | 9.61 | 19 | 169308 | 2067 | 64327338 |
Incorrect product dosage form administered | 10.10 | 9.61 | 6 | 169321 | 162 | 64329243 |
Hepatic amoebiasis | 10.09 | 9.61 | 5 | 169322 | 93 | 64329312 |
Prescribed underdose | 10.08 | 9.61 | 20 | 169307 | 17995 | 64311410 |
Bundle branch block left | 10.07 | 9.61 | 7 | 169320 | 10027 | 64319378 |
Full blood count abnormal | 10.06 | 9.61 | 42 | 169285 | 29715 | 64299690 |
Procalcitonin increased | 10.04 | 9.61 | 21 | 169306 | 2470 | 64326935 |
Skin injury | 10.03 | 9.61 | 19 | 169308 | 2080 | 64327325 |
Ventricular tachyarrhythmia | 10.03 | 9.61 | 7 | 169320 | 251 | 64329154 |
Toxic shock syndrome | 10.02 | 9.61 | 12 | 169315 | 874 | 64328531 |
Abnormal faeces | 10.00 | 9.61 | 36 | 169291 | 5823 | 64323582 |
Pneumonia fungal | 9.99 | 9.61 | 48 | 169279 | 8829 | 64320576 |
Medical device site pain | 9.98 | 9.61 | 7 | 169320 | 253 | 64329152 |
Biopsy colon abnormal | 9.95 | 9.61 | 5 | 169322 | 96 | 64329309 |
Needle issue | 9.94 | 9.61 | 6 | 169321 | 9266 | 64320139 |
Infective exacerbation of bronchiectasis | 9.92 | 9.61 | 11 | 169316 | 737 | 64328668 |
Penile pain | 9.92 | 9.61 | 12 | 169315 | 883 | 64328522 |
Peripheral arterial occlusive disease | 9.91 | 9.61 | 3 | 169324 | 6984 | 64322421 |
Aural polyp | 9.90 | 9.61 | 5 | 169322 | 97 | 64329308 |
Taste disorder | 9.90 | 9.61 | 50 | 169277 | 9383 | 64320022 |
Splenic abscess | 9.89 | 9.61 | 9 | 169318 | 475 | 64328930 |
Diarrhoea infectious | 9.89 | 9.61 | 15 | 169312 | 1371 | 64328034 |
Fatigue | 9.87 | 9.61 | 1773 | 167554 | 746957 | 63582448 |
Tooth fracture | 9.86 | 9.61 | 7 | 169320 | 9920 | 64319485 |
Immunodeficiency | 9.82 | 9.61 | 17 | 169310 | 16107 | 64313298 |
Osteopenia | 9.82 | 9.61 | 16 | 169311 | 15524 | 64313881 |
Renal abscess | 9.79 | 9.61 | 12 | 169315 | 895 | 64328510 |
Fungal infection | 9.79 | 9.61 | 135 | 169192 | 34116 | 64295289 |
Leukopenia | 9.78 | 9.61 | 341 | 168986 | 100901 | 64228504 |
Coagulation time prolonged | 9.73 | 9.61 | 19 | 169308 | 2127 | 64327278 |
Candida test positive | 9.73 | 9.61 | 13 | 169314 | 1057 | 64328348 |
Injection site urticaria | 9.72 | 9.61 | 9 | 169318 | 11172 | 64318233 |
Vision blurred | 9.69 | 9.61 | 308 | 169019 | 90008 | 64239397 |
Liver function test increased | 9.69 | 9.61 | 45 | 169282 | 30925 | 64298480 |
White blood cells urine | 9.69 | 9.61 | 8 | 169319 | 370 | 64329035 |
Pseudomonas test positive | 9.69 | 9.61 | 16 | 169311 | 1572 | 64327833 |
Vascular purpura | 9.67 | 9.61 | 21 | 169306 | 2535 | 64326870 |
Vipoma | 9.67 | 9.61 | 3 | 169324 | 14 | 64329391 |
Internal haemorrhage | 9.67 | 9.61 | 4 | 169323 | 7663 | 64321742 |
Ligament injury | 9.66 | 9.61 | 13 | 169314 | 1064 | 64328341 |
Injection site streaking | 9.65 | 9.61 | 4 | 169323 | 48 | 64329357 |
Blood urine | 9.65 | 9.61 | 11 | 169316 | 760 | 64328645 |
Encephalopathy | 9.62 | 9.61 | 212 | 169115 | 58607 | 64270798 |
None
Source | Code | Description |
---|---|---|
ATC | J01MA02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Fluoroquinolones |
ATC | J01RA10 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
ATC | J01RA11 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
ATC | J01RA12 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
ATC | S01AE03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Fluoroquinolones |
ATC | S02AA15 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
ATC | S03AA07 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives |
FDA CS | M0023650 | Quinolones |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D065609 | Cytochrome P-450 CYP1A2 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D059005 | Topoisomerase II Inhibitors |
FDA EPC | N0000175937 | Quinolone Antimicrobial |
CHEBI has role | CHEBI:35441 | antiinfective agents |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:50750 | inhibitors of type II topoisomerase |
CHEBI has role | CHEBI:53559 | topoisomerase IV inhibitors |
CHEBI has role | CHEBI:33281 | antibiotics |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:59517 | DNA synthesis inhibitors |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Otitis externa | indication | 3135009 | |
Typhoid fever | indication | 4834000 | DOID:13258 |
Septicemia due to Escherichia coli | indication | 9323009 | |
Prostatitis | indication | 9713002 | DOID:14654 |
Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
Enteric campylobacteriosis | indication | 18081009 | |
Infectious diarrheal disease | indication | 19213003 | DOID:13250 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Acute gonococcal urethritis | indication | 29864006 | |
Acute bacterial peritonitis | indication | 31860008 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Shigellosis | indication | 36188001 | |
Cystitis | indication | 38822007 | DOID:1679 |
Pneumonia due to Pseudomonas | indication | 41381004 | |
Lower respiratory tract infection | indication | 50417007 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Acute maxillary sinusitis | indication | 68272006 | DOID:2050 |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Abdominal abscess | indication | 75100008 | |
Acute bacterial sinusitis | indication | 75498004 | |
Infective otitis externa | indication | 86981007 | DOID:9463 |
Infection of bone | indication | 111253001 | |
Infectious disease of abdomen | indication | 128070006 | |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Acute Moraxella catarrhalis bronchitis | indication | 195722003 | |
Proteus pneumonia | indication | 195888009 | |
Malignant otitis externa due to Pseudomonas aeruginosa | indication | 232230009 | |
Acute bacterial bronchitis | indication | 233598009 | |
Infective cystitis | indication | 236620008 | |
Chancroid | indication | 266143009 | DOID:13778 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Infectious disorder of joint | indication | 363162000 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Anthrax | indication | 409498004 | DOID:7427 |
Acute osteomyelitis | indication | 409780002 | |
Nosocomial pneumonia | indication | 425464007 | |
Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
Pseudomonas Aeruginosa Joint Infection | indication | ||
Complicated UTI with Pseudomonas Aeruginosa | indication | ||
Staphylococcus Epidermidis Urinary Tract Infection | indication | ||
Complicated Proteus UTI | indication | ||
Skin and Skin Structure Providencia Infection | indication | ||
Complicated Bacterial Peritonitis | indication | ||
Staphylococcus Saprophyticus Urinary Tract Infection | indication | ||
Haemophilus Parainfluenzae Pneumonia | indication | ||
Enterobacter Pneumonia | indication | ||
Skin and Skin Structure Citrobacter Infection | indication | ||
Moraxella Catarrhalis Chronic Bronchitis | indication | ||
Diarrhea due to E. Coli | indication | ||
Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
Klebsiella Nosocomial Pneumonia | indication | ||
Citrobacter Urinary Tract Infection | indication | ||
Enterococcus Urinary Tract Infection | indication | ||
Serratia Joint Infection | indication | ||
Skin and Skin Structure Proteus Infection | indication | ||
EnterobacterJoint Infection | indication | ||
Enterobacter Osteomyelitis | indication | ||
Nosocomial Pneumonia due to Haemophilus Influenzae | indication | ||
Complicated Bacteroides Peritonitis | indication | ||
Complicated E. Coli Peritonitis | indication | ||
Morganella Morganii Urinary Tract Infection | indication | ||
Bacterial Corneal Ulcer Infection | indication | ||
Enterococcus Complicated UTI | indication | ||
Providencia Urinary Tract Infection | indication | ||
E. Coli Cystitis | indication | ||
Staphylococcus Aureus Otitis Externa | indication | ||
Staphylococcus Cystitis | indication | ||
Chronic Bacterial Prostatitis | indication | ||
Pseudomonas Aeruginosa Urinary Tract Infection | indication | ||
Gram-Negative Aerobic Bacillary Pneumonia | indication | ||
Serratia Osteomyelitis | indication | ||
Staphylococcus Epidermidis Skin and Skin Structure Infection | indication | ||
Complicated Klebsiella Peritonitis | indication | ||
Skin and Skin Structure Serratia Infection | indication | ||
Proteus Prostatitis | indication | ||
E. Coli Pyelonephritis | indication | ||
Skin and Skin Structure Morganella Morganii Infection | indication | ||
Serratia Urinary Tract Infection | indication | ||
Pseudomonas Aeruginosa Osteomyelitis | indication | ||
Inhalational anthrax | off-label use | 11389007 | |
Traveler's diarrhea | off-label use | 11840006 | |
Salmonella septicemia | off-label use | 49786009 | |
Cutaneous anthrax | off-label use | 84980006 | DOID:7426 |
Gastrointestinal anthrax | off-label use | 111798006 | DOID:13386 |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Ventilator-acquired pneumonia | off-label use | 429271009 | |
Prevention of Meningococcal Meningitis | off-label use | ||
Diabetic Foot Infection | off-label use | ||
Achilles tendinitis | contraindication | 11654001 | |
Lowered convulsive threshold | contraindication | 19260006 | |
Torsades de pointes | contraindication | 31722008 | |
Transplantation of heart | contraindication | 32413006 | |
Tendinitis | contraindication | 34840004 | DOID:971 |
Hypokalemia | contraindication | 43339004 | |
Transplant of kidney | contraindication | 70536003 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Transplant of lung | contraindication | 88039007 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Prolonged QT interval | contraindication | 111975006 | |
Superimposed infection | contraindication | 193198003 | |
Peripheral nerve disease | contraindication | 302226006 | |
Viral ear infection | contraindication | 312137007 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Traumatic rupture of tendon | contraindication | 415749005 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Shoulder Tendonitis | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.12 | acidic |
pKa2 | 8.54 | Basic |
pKa3 | 1.37 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.3%;0.1% | CIPRODEX | NOVARTIS | N021537 | July 18, 2003 | RX | SUSPENSION/DROPS | OTIC | 9149486 | Sept. 13, 2022 | TREATMENT OF ACUTE OTITIS MEDIA |
0.3%;0.1% | CIPRODEX | NOVARTIS | N021537 | July 18, 2003 | RX | SUSPENSION/DROPS | OTIC | 9345714 | Sept. 13, 2022 | TREATMENT OF ACUTE OTITIS MEDIA |
0.3%;0.1% | CIPRODEX | NOVARTIS | N021537 | July 18, 2003 | RX | SUSPENSION/DROPS | OTIC | 9402805 | Sept. 13, 2022 | TREATMENT OF ACUTE OTITIS EXTERNA |
0.3%;0.1% | CIPRODEX | NOVARTIS | N021537 | July 18, 2003 | RX | SUSPENSION/DROPS | OTIC | 9402805 | Sept. 13, 2022 | TREATMENT OF ACUTE OTITIS MEDIA |
0.3%;0.1% | CIPRODEX | NOVARTIS | N021537 | July 18, 2003 | RX | SUSPENSION/DROPS | OTIC | 8846650 | June 4, 2025 | TREATMENT OF ACUTE OTITIS MEDIA |
6% (60MG/ML) | OTIPRIO | ALK ABELLO | N207986 | Dec. 10, 2015 | RX | INJECTABLE, SUSPENSION | OTIC | 9205048 | April 21, 2029 | TREATMENT OF PEDIATRIC PATIENTS WITH OTITIS MEDIA WITH EFFUSION UNDERGOING TYMPANOSTOMY TUBE PLACEMENT |
6% (60MG/ML) | OTIPRIO | ALK ABELLO | N207986 | Dec. 10, 2015 | RX | INJECTABLE, SUSPENSION | OTIC | 9603796 | April 21, 2029 | THE TREATMENT OF ACUTE OTITIS EXTERNA IN PATIENTS 6 MONTHS OF AGE AND OLDER DUE TO PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS |
EQ 0.3% BASE;0.025% | OTOVEL | LABORATORIOS SALVAT | N208251 | April 29, 2016 | RX | SOLUTION/DROPS | OTIC | 8932610 | March 24, 2030 | TREATMENT OF ACUTE OTITIS MEDIA |
6% (60MG/ML) | OTIPRIO | ALK ABELLO | N207986 | Dec. 10, 2015 | RX | INJECTABLE, SUSPENSION | OTIC | 8318817 | April 27, 2030 | TREATMENT OF OTIC INFECTION OR INFLAMMATION |
6% (60MG/ML) | OTIPRIO | ALK ABELLO | N207986 | Dec. 10, 2015 | RX | INJECTABLE, SUSPENSION | OTIC | 11040004 | Nov. 12, 2037 | THE TREATMENT OF ACUTE OTITIS EXTERNA IN PATIENTS 6 MONTHS OF AGE AND OLDER DUE TO PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase II | Enzyme | EC50 | 7.52 | CHEMBL | |||||
DNA gyrase subunit A | Enzyme | INHIBITOR | IC50 | 5.75 | WOMBAT-PK | CHEMBL | |||
DNA topoisomerase 4 subunit A | Enzyme | IC50 | 5.66 | WOMBAT-PK | |||||
DNA topoisomerase 4 subunit A | Enzyme | INHIBITOR | IC50 | 6 | WOMBAT-PK | ||||
DNA gyrase subunit A | Enzyme | IC50 | 6.20 | WOMBAT-PK | |||||
Histamine H3 receptor | GPCR | Ki | 9.18 | CHEMBL | |||||
GABA-A receptor; anion channel | Ion channel | IC50 | 6.39 | CHEMBL | |||||
DNA topoisomerase 4 subunit A | Enzyme | IC50 | 5.60 | WOMBAT-PK | |||||
Multidrug resistance protein mdtK | Unclassified | Kd | 4.04 | CHEMBL |
ID | Source |
---|---|
4019307 | VUID |
N0000147503 | NUI |
D00186 | KEGG_DRUG |
86393-32-0 | SECONDARY_CAS_RN |
235851 | RXNORM |
4019306 | VANDF |
4019307 | VANDF |
C0008809 | UMLSCUI |
CHEBI:100241 | CHEBI |
CPF | PDB_CHEM_ID |
CHEMBL8 | ChEMBL_ID |
DB00537 | DRUGBANK_ID |
CHEMBL1202 | ChEMBL_ID |
D002939 | MESH_DESCRIPTOR_UI |
2764 | PUBCHEM_CID |
10902 | IUPHAR_LIGAND_ID |
5446 | INN_ID |
97867-33-9 | SECONDARY_CAS_RN |
5E8K9I0O4U | UNII |
31644 | MMSL |
4451 | MMSL |
4452 | MMSL |
46904 | MMSL |
76342 | MMSL |
d00011 | MMSL |
002882 | NDDF |
003577 | NDDF |
004125 | NDDF |
20450009 | SNOMEDCT_US |
372840008 | SNOMEDCT_US |
428384006 | SNOMEDCT_US |
7577004 | SNOMEDCT_US |
CHEMBL1077975 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ciloxan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0656 | SOLUTION/ DROPS | 3 mg | OPHTHALMIC | NDA | 21 sections |
Ciloxan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0656 | SOLUTION/ DROPS | 3 mg | OPHTHALMIC | NDA | 21 sections |
CIPROHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-8531 | SUSPENSION | 2 mg | AURICULAR (OTIC) | NDA | 16 sections |
CIPRODEX | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0799 | SUSPENSION/ DROPS | 3 mg | AURICULAR (OTIC) | NDA | 28 sections |
CIPRODEX | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0799 | SUSPENSION/ DROPS | 3 mg | AURICULAR (OTIC) | NDA | 28 sections |
CILOXAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0841 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 20 sections |
CILOXAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0841 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 20 sections |
CIPROHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0855 | SUSPENSION/ DROPS | 2 mg | AURICULAR (OTIC) | NDA | 16 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9927 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 30 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9928 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 30 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9929 | TABLET, FILM COATED | 750 mg | ORAL | ANDA | 30 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0172-5311 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0172-5312 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0172-5313 | TABLET, FILM COATED | 750 mg | ORAL | ANDA | 29 sections |
OTIPRIO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0268-8200 | SUSPENSION | 60 mg | INTRATYMPANIC | NDA | 26 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-7187 | SOLUTION/ DROPS | 3 mg | OPHTHALMIC | ANDA | 24 sections |
CIPROFLOXACIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4777 | INJECTION, SOLUTION | 2 mg | INTRAVENOUS | ANDA | 34 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8147 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8367 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 31 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8367 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 31 sections |
Ciprofloxacin and Dexamethasone | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0781-6186 | SUSPENSION/ DROPS | 3 mg | AURICULAR (OTIC) | NDA authorized generic | 27 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6378 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6378 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7083 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 30 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-036 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-079 | TABLET | 500 mg | ORAL | ANDA | 27 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-147 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 27 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-432 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-603 | TABLET | 250 mg | ORAL | ANDA | 27 sections |
CIPROFLOXACIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-604 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 28 sections |