ciprofloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 659 85721-33-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ciprofloxacin
  • ciprofloxacin hydrochloride
  • ciprofloxacillin
  • ciprofloxacine
  • ciprofloxacin hydrochloride monohydrate
  • ciprofloxacin HCl
  • ciprofloxacin lactate
A broad-spectrum antimicrobial carboxyfluoroquinoline.
  • Molecular weight: 331.35
  • Formula: C17H18FN3O3
  • CLOGP: -0.47
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 72.88
  • ALOGS: -2.39
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O
0.80 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.15 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 65 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.49 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.80 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.655 Moderate 0.67
caco2-efflux Caco-2 efflux ratio (BA/AB) 3.412 Moderate 0.67
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 2.547 10^-6 cm/s Moderate 0.67
dh-clint Dog hepatocyte intrinsic clearance 1.442 uL/min/10^6 cells Moderate 0.67
dppb Dog plasma protein binding (% unbound) 80.900 % Moderate 0.67
fcs-ppb Fetal calf serum protein binding (% unbound) 83.840 % Moderate 0.67
herg hERG pIC50 4.441 pIC50 Moderate 0.67
hh-clint Human hepatocyte intrinsic clearance 1.285 uL/min/10^6 cells Moderate 0.67
hlm-clint Human liver microsomal intrinsic clearance 3.236 uL/min/mg protein Moderate 0.67
hppb Human plasma protein binding (% unbound) 75.640 % Moderate 0.67
kinase-safety-class ACVR2B,EIF2AK3,GRK2,PDK1,PDK2,PDK4,PRKDC 7
kinase-selectivity-class AXL,CDK9,DYRK1B,EIF2AK3,GRK2,MAPK7,PDK4,PIK3CB,PIK3CD,PRKDC,STK33,SYK,TEK,TGFBR1,TTK 15
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.167 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 7.211 Moderate 0.67
mh-clint Mouse hepatocyte intrinsic clearance 2.951 Moderate 0.67
mppb Mouse plasma protein binding (% unbound) 79.170 Moderate 0.67
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 12.190 Moderate 0.67
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 83.620 % Moderate 0.67
rat-kpuu-brain Rat brain Kpuu 0.091 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.374 uL/min/10^6 cells Moderate 0.67
rh-fuinc Rat hepatocyte fraction unbound in incubation 87.770 % Moderate 0.67
rppb Rat plasma protein binding (% unbound) 66.560 % Moderate 0.67
solubility-dd Solubility at pH 7.4 in DMSO 676.083 uM Moderate 0.67

Approvals:

DateAgencyCompanyOrphan
Oct. 22, 1987 FDA BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1903.67 9.75 3107 154770 460502 90010068
Tendon pain 719.45 9.75 264 157613 3484 90467086
Tendonitis 604.08 9.75 407 157470 20965 90449605
Pemphigus 537.10 9.75 6 157871 326858 90143712
Hand deformity 475.75 9.75 8 157869 296354 90174216
Drug reaction with eosinophilia and systemic symptoms 457.92 9.75 463 157414 42295 90428275
Glossodynia 440.70 9.75 31 157846 321748 90148822
Abortion spontaneous 431.13 9.75 501 157376 53555 90417015
Drug interaction 401.08 9.75 1224 156653 275229 90195341
Synovitis 398.39 9.75 52 157825 329700 90140870
Pericarditis 391.28 9.75 19 157858 270132 90200438
Tendon disorder 377.18 9.75 199 157678 6501 90464069
Anti-cyclic citrullinated peptide antibody positive 376.87 9.75 7 157870 236426 90234144
Systemic lupus erythematosus 374.06 9.75 86 157791 361810 90108760
Acute kidney injury 369.34 9.75 1312 156565 319075 90151495
Duodenal ulcer perforation 363.68 9.75 4 157873 221284 90249286
Helicobacter infection 345.25 9.75 11 157866 226839 90243731
Toxic epidermal necrolysis 335.13 9.75 345 157532 32183 90438387
Tendon rupture 332.75 9.75 205 157672 9038 90461532
Nasal oedema 332.67 9.75 182 157695 6402 90464168
Tubulointerstitial nephritis 315.40 9.75 298 157579 25045 90445525
Pathogen resistance 299.84 9.75 183 157694 7932 90462638
Arthropathy 278.94 9.75 145 157732 366097 90104473
Rheumatoid factor positive 273.84 9.75 5 157872 171645 90298925
Wound 272.21 9.75 94 157783 302886 90167684
Psoriatic arthropathy 270.94 9.75 38 157839 228297 90242273
Muscle injury 270.82 9.75 8 157869 176646 90293924
Rheumatoid arthritis 269.65 9.75 148 157729 362466 90108104
Folliculitis 257.13 9.75 28 157849 204325 90266245
Stevens-Johnson syndrome 247.22 9.75 280 157597 29096 90441474
Clostridium difficile colitis 244.46 9.75 266 157611 26440 90444130
Alopecia 242.43 9.75 304 157573 494767 89975803
Type 2 diabetes mellitus 240.72 9.75 34 157843 203210 90267360
Clostridium difficile infection 232.41 9.75 301 157576 35944 90434626
Total lung capacity increased 224.26 9.75 128 157749 4893 90465677
Respiratory tract infection 215.63 9.75 377 157500 58701 90411869
Asthma-chronic obstructive pulmonary disease overlap syndrome 211.09 9.75 122 157755 4777 90465793
Joint swelling 209.02 9.75 347 157530 502953 89967617
Discomfort 203.82 9.75 112 157765 274223 90196347
Contraindicated product administered 197.16 9.75 161 157716 319978 90150592
Oedema 188.18 9.75 769 157108 199526 90271044
Infusion related reaction 186.66 9.75 273 157604 416507 90054063
Vomiting 177.39 9.75 2124 155753 786169 89684401
Ill-defined disorder 175.49 9.75 52 157825 184839 90285731
Therapeutic product effect decreased 171.63 9.75 139 157738 277432 90193138
Nasal polyps 169.04 9.75 145 157732 10735 90459835
Irritable bowel syndrome 165.59 9.75 77 157800 207371 90263199
Treatment failure 161.12 9.75 175 157702 303753 90166817
Colitis 160.81 9.75 368 157509 69574 90400996
Blood cholesterol increased 160.26 9.75 81 157796 207931 90262639
Impaired healing 159.41 9.75 106 157771 234093 90236477
Maternal exposure during pregnancy 156.19 9.75 241 157636 359822 90110748
Facet joint syndrome 152.45 9.75 4 157873 98385 90372185
Wheezing 148.78 9.75 812 157065 237268 90233302
Lip dry 146.39 9.75 7 157870 100948 90369622
Peripheral swelling 142.44 9.75 318 157559 412788 90057782
Swelling 140.91 9.75 327 157550 418731 90051839
Female genital tract fistula 139.72 9.75 164 157713 17704 90452866
Stomatitis 137.09 9.75 166 157711 274532 90196038
Sarcoidosis 135.65 9.75 127 157750 10546 90460024
Drug resistance 134.85 9.75 212 157665 30237 90440333
Joint range of motion decreased 134.58 9.75 35 157842 135608 90334962
Rash maculo-papular 133.77 9.75 249 157628 40684 90429886
Mobility decreased 133.27 9.75 144 157733 250590 90219980
Swollen tongue 131.17 9.75 264 157613 45692 90424878
Nasopharyngitis 130.28 9.75 326 157551 406778 90063792
Anal fistula 128.96 9.75 85 157792 4216 90466354
Asthma 126.66 9.75 788 157089 241372 90229198
Fistula 125.91 9.75 129 157748 11960 90458610
Myalgia 125.79 9.75 621 157256 174504 90296066
Swelling face 125.04 9.75 368 157509 80984 90389586
Abdominal pain 123.45 9.75 1140 156737 394581 90075989
Hepatic enzyme increased 123.26 9.75 279 157598 360457 90110113
Loss of employment 122.39 9.75 72 157805 2915 90467655
Prescribed overdose 121.18 9.75 14 157863 97611 90372959
Tinnitus 119.92 9.75 245 157632 42857 90427713
Liver injury 117.67 9.75 76 157801 170491 90300079
Hypercholesterolaemia 116.82 9.75 18 157859 100874 90369696
Abdominal discomfort 115.83 9.75 434 157443 476894 89993676
Grip strength decreased 115.60 9.75 13 157864 92563 90378007
Proctitis 114.27 9.75 137 157740 15122 90455448
Bursitis 112.81 9.75 44 157833 131610 90338960
Burning sensation 112.19 9.75 302 157575 63150 90407420
Pneumonia 110.71 9.75 1641 156236 636418 89834152
Crystal nephropathy 109.62 9.75 49 157828 1102 90469468
Vaginal flatulence 108.94 9.75 122 157755 12516 90458054
Sciatica 108.86 9.75 22 157855 101360 90369210
Product use issue 108.81 9.75 260 157617 329659 90140911
Dysbiosis 108.60 9.75 55 157822 1647 90468923
Rhinitis allergic 108.53 9.75 140 157737 16645 90453925
Peripheral venous disease 106.79 9.75 11 157866 83910 90386660
Road traffic accident 104.44 9.75 29 157848 107597 90362973
Multiple organ dysfunction syndrome 103.00 9.75 307 157570 68029 90402541
Bronchiectasis 102.40 9.75 158 157719 22172 90448398
Live birth 101.63 9.75 10 157867 79097 90391473
Fibromyalgia 100.41 9.75 127 157750 206142 90264428
Weight increased 99.41 9.75 383 157494 417544 90053026
Cholecystitis chronic 98.99 9.75 103 157774 9723 90460847
Renal tubular necrosis 98.21 9.75 124 157753 14431 90456139
C-reactive protein abnormal 97.55 9.75 50 157827 127379 90343191
Cardiac murmur 96.74 9.75 138 157739 18056 90452514
Dysphonia 96.59 9.75 285 157592 62799 90407771
Eosinophilia 95.02 9.75 175 157702 28358 90442212
Dermatitis exfoliative 94.71 9.75 78 157799 5458 90465112
Hip arthroplasty 94.41 9.75 11 157866 76197 90394373
Tendon injury 94.13 9.75 55 157822 2198 90468372
Urinary tract infection 93.99 9.75 878 156999 304754 90165816
Chronic sinusitis 93.54 9.75 157 157720 23645 90446925
Radiculopathy 93.50 9.75 137 157740 18368 90452202
Wound infection 92.08 9.75 35 157842 106367 90364203
Sinusitis 91.17 9.75 300 157577 342788 90127782
Paraesthesia oral 90.50 9.75 182 157695 31477 90439093
Intentional product use issue 88.50 9.75 151 157726 216741 90253829
Erythema 88.05 9.75 692 157185 228554 90242016
Haematochezia 87.17 9.75 297 157580 70616 90399954
Angioedema 87.14 9.75 280 157597 64596 90405974
Cholelithiasis 85.97 9.75 243 157634 52263 90418307
Vaginal discharge 85.46 9.75 135 157742 19329 90451241
Adjustment disorder with depressed mood 85.41 9.75 3 157874 56750 90413820
Jaundice cholestatic 84.95 9.75 96 157781 9947 90460623
Pseudomembranous colitis 84.58 9.75 63 157814 3805 90466765
Lower limb fracture 84.20 9.75 22 157855 84991 90385579
Tendon discomfort 83.63 9.75 28 157849 276 90470294
Acute generalised exanthematous pustulosis 83.49 9.75 111 157766 13592 90456978
Torsade de pointes 81.97 9.75 116 157761 15066 90455504
Sepsis 81.71 9.75 565 157312 179249 90291321
Early retirement 80.59 9.75 16 157861 6 90470564
Fall 80.18 9.75 501 157376 481309 89989261
Clostridium test positive 79.90 9.75 70 157807 5331 90465239
Drug ineffective for unapproved indication 78.32 9.75 275 157602 66369 90404201
Geotrichum infection 77.72 9.75 32 157845 584 90469986
Panic attack 77.08 9.75 153 157724 26212 90444358
Hypomania 76.88 9.75 86 157791 8811 90461759
Diverticulitis 76.81 9.75 212 157665 44975 90425595
Skin candida 76.72 9.75 44 157833 1697 90468873
Cough 76.48 9.75 980 156897 367982 90102588
Osteoarthritis 75.59 9.75 141 157736 195589 90274981
Amyloid arthropathy 75.49 9.75 43 157834 1637 90468933
Blister 74.09 9.75 214 157663 254784 90215786
Autoimmune disorder 73.86 9.75 21 157856 76723 90393847
Pulmonary pain 73.10 9.75 65 157812 5049 90465521
Chronic kidney disease 72.35 9.75 222 157655 49969 90420601
Adverse event 72.26 9.75 59 157818 117359 90353211
Dry mouth 71.60 9.75 132 157745 183927 90286643
Lower respiratory tract infection 70.91 9.75 213 157664 250446 90220124
Musculoskeletal stiffness 70.30 9.75 272 157605 296260 90174310
Prescribed underdose 69.52 9.75 22 157855 74997 90395573
Febrile neutropenia 69.26 9.75 493 157384 157856 90312714
Henoch-Schonlein purpura 68.72 9.75 40 157837 1587 90468983
Pulmonary fibrosis 68.70 9.75 52 157825 107451 90363119
Oral candidiasis 68.02 9.75 174 157703 35281 90435289
Pseudomonas infection 67.91 9.75 105 157772 14760 90455810
Drug ineffective 67.65 9.75 1867 156010 1382431 89088139
Abdominal pain lower 67.38 9.75 157 157720 30020 90440550
Psoriasis 66.79 9.75 96 157781 147658 90322912
Diarrhoea 66.41 9.75 2121 155756 937069 89533501
Injection site reaction 66.30 9.75 39 157838 92041 90378529
Trimethylaminuria 66.27 9.75 21 157856 171 90470399
Blepharospasm 66.25 9.75 9 157868 55436 90415134
Nephritis allergic 66.14 9.75 24 157853 306 90470264
Staphylococcal infection 65.90 9.75 210 157667 48229 90422341
Death 65.41 9.75 496 157381 456055 90014515
Connective tissue disorder 65.21 9.75 40 157837 1749 90468821
Completed suicide 64.84 9.75 95 157782 144963 90325607
Intentional overdose 64.43 9.75 42 157835 93792 90376778
Anxiety 63.41 9.75 821 157056 308951 90161619
Abscess 63.07 9.75 116 157761 18775 90451795
Pancytopenia 61.96 9.75 390 157487 119873 90350697
Onychomadesis 61.28 9.75 5 157872 45993 90424577
Frequent bowel movements 61.02 9.75 228 157649 56707 90413863
Musculoskeletal injury 60.92 9.75 19 157858 146 90470424
Product quality issue 60.89 9.75 31 157846 79294 90391276
Injection site pain 60.35 9.75 133 157744 173566 90297004
Neutropenia 60.27 9.75 628 157249 224276 90246294
Neuropathy peripheral 59.64 9.75 426 157451 136544 90334026
Anal abscess 59.60 9.75 61 157816 5647 90464923
Disturbance in attention 59.38 9.75 199 157678 46910 90423660
Mucosal inflammation 57.84 9.75 226 157651 57399 90413171
Symmetrical drug-related intertriginous and flexural exanthema 57.73 9.75 30 157847 949 90469621
Hallucination 56.99 9.75 247 157630 65712 90404858
Blood bilirubin increased 56.91 9.75 186 157691 43284 90427286
Night sweats 56.89 9.75 85 157792 128681 90341889
Pyelonephritis 56.74 9.75 119 157758 21197 90449373
Therapeutic response decreased 56.57 9.75 44 157833 89685 90380885
Sleep disorder due to a general medical condition 56.57 9.75 6 157871 44732 90425838
Joint noise 56.09 9.75 57 157820 5233 90465337
Segmental diverticular colitis 55.82 9.75 18 157859 156 90470414
Drug intolerance 55.16 9.75 506 157371 447085 90023485
Lung neoplasm malignant 54.98 9.75 127 157750 24146 90446424
Aspergillus infection 54.49 9.75 80 157797 10743 90459827
Foot deformity 54.38 9.75 18 157859 59633 90410937
Sleep disorder 54.06 9.75 171 157706 197859 90272711
Emotional distress 53.62 9.75 163 157714 36499 90434071
Anal fissure 53.44 9.75 56 157821 5329 90465241
Nervous system disorder 53.40 9.75 117 157760 21476 90449094
Infective pulmonary exacerbation of cystic fibrosis 53.23 9.75 77 157800 10202 90460368
Hallucinations, mixed 52.74 9.75 58 157819 5831 90464739
Oesophageal spasm 52.63 9.75 45 157832 3316 90467254
Exostosis 52.14 9.75 14 157863 53120 90417450
Vulvovaginal burning sensation 51.73 9.75 40 157837 2555 90468015
Persistent genital arousal disorder 51.73 9.75 25 157852 675 90469895
Pedal pulse abnormal 51.36 9.75 18 157859 206 90470364
General physical health deterioration 51.21 9.75 385 157492 354730 90115840
Hepatic cirrhosis 51.18 9.75 23 157854 63230 90407340
Pregnancy 51.09 9.75 22 157855 62025 90408545
Contusion 50.62 9.75 245 157632 250971 90219599
Liver function test increased 50.53 9.75 44 157833 84811 90385759
Device expulsion 50.39 9.75 6 157871 40880 90429690
Lung disorder 49.45 9.75 118 157759 149765 90320805
Therapy non-responder 48.87 9.75 103 157774 136601 90333969
Megacolon 48.27 9.75 36 157841 2178 90468392
Thermal burn 47.85 9.75 59 157818 6703 90463867
Dyspnoea 47.54 9.75 1930 155947 879025 89591545
Flank pain 47.36 9.75 104 157773 19118 90451452
Onychomycosis 47.29 9.75 5 157872 37371 90433199
Hypertension 47.01 9.75 540 157337 456992 90013578
Bacterial colitis 46.89 9.75 16 157861 168 90470402
Thrombocytopenia 46.88 9.75 563 157314 208162 90262408
Fungaemia 46.73 9.75 42 157835 3308 90467262
Malaise 45.44 9.75 1339 156538 584647 89885923
Osteoporosis 45.34 9.75 61 157816 96470 90374100
Food intolerance 44.98 9.75 44 157833 3858 90466712
Pyrexia 44.83 9.75 1485 156392 659000 89811570
Candida infection 44.83 9.75 146 157731 33911 90436659
Hepatic steatosis 44.75 9.75 154 157723 36791 90433779
Cystitis 44.63 9.75 232 157645 66486 90404084
Fatigue 43.32 9.75 1610 156267 1152413 89318157
Psychotic disorder 43.03 9.75 136 157741 31094 90439476
Retinitis viral 43.00 9.75 17 157860 278 90470292
Lymphoedema 42.86 9.75 82 157795 13671 90456899
Knee arthroplasty 42.81 9.75 49 157828 83133 90387437
Calcium ionised decreased 42.67 9.75 18 157859 350 90470220
Arthritis 42.56 9.75 149 157728 167166 90303404
Schizophrenia 41.74 9.75 85 157792 14829 90455741
Oliguria 41.64 9.75 70 157807 10554 90460016
Injection site erythema 41.62 9.75 67 157810 98435 90372135
Protothecosis 41.53 9.75 19 157858 452 90470118
Impaired work ability 41.46 9.75 99 157778 19227 90451343
Wound complication 41.09 9.75 46 157831 4717 90465853
Gait inability 41.00 9.75 125 157752 146331 90324239
Infrequent bowel movements 40.79 9.75 28 157849 1486 90469084
Toxic skin eruption 40.76 9.75 87 157790 15687 90454883
Lupus-like syndrome 40.73 9.75 17 157860 48829 90421741
Gastrointestinal disorder 40.54 9.75 271 157606 256416 90214154
Blood creatinine increased 40.51 9.75 309 157568 101077 90369493
Large intestine infection 40.44 9.75 35 157842 2622 90467948
Leukocytosis 40.02 9.75 132 157745 30858 90439712
Amnesia 39.42 9.75 81 157796 108424 90362146
Muscle atrophy 39.30 9.75 60 157817 8341 90462229
Oesophageal pain 39.03 9.75 43 157834 4331 90466239
Taste disorder 39.02 9.75 30 157847 61516 90409054
Incorrect route of product administration 38.53 9.75 20 157857 50606 90419964
Nail disorder 38.47 9.75 28 157849 59039 90411531
Ectropion 38.24 9.75 15 157862 240 90470330
Septic shock 36.76 9.75 262 157615 83898 90386672
Fistula discharge 36.56 9.75 23 157854 1052 90469518
Factor V deficiency 36.54 9.75 11 157866 74 90470496
Coeliac disease 36.44 9.75 16 157861 44594 90425976
Excessive eye blinking 36.08 9.75 25 157852 1347 90469223
Procedural anxiety 36.04 9.75 21 157856 835 90469735
Abnormal palmar/plantar creases 35.88 9.75 10 157867 49 90470521
Nausea 35.53 9.75 2314 155563 1108002 89362568
Klebsiella infection 35.35 9.75 64 157813 10233 90460337
Exposure during pregnancy 35.05 9.75 257 157620 238153 90232417
Mitochondrial cytopathy 35.02 9.75 14 157863 236 90470334
Pouchitis 34.99 9.75 19 157858 658 90469912
Neutropenic sepsis 34.80 9.75 89 157788 18041 90452529
Myoclonus 34.64 9.75 92 157785 19076 90451494
Malignant neoplasm progression 34.56 9.75 85 157792 106785 90363785
Hepatitis cholestatic 34.34 9.75 57 157820 8504 90462066
Gut fermentation syndrome 34.08 9.75 8 157869 16 90470554
Suicide attempt 34.05 9.75 49 157828 75350 90395220
Fungal infection 34.02 9.75 156 157721 42505 90428065
Walking aid user 33.64 9.75 10 157867 35496 90435074
Dysuria 33.61 9.75 147 157730 39254 90431316
Pulmonary eosinophilia 33.45 9.75 15 157862 340 90470230
Accidental exposure to product 33.35 9.75 16 157861 42350 90428220
Idiopathic intracranial hypertension 33.34 9.75 36 157841 3545 90467025
Renal failure 33.28 9.75 362 157515 130645 90339925
Arrhythmia 33.16 9.75 154 157723 42178 90428392
C-reactive protein increased 33.09 9.75 183 157694 181206 90289364
Chronic obstructive pulmonary disease 32.92 9.75 231 157646 73598 90396972
Rhabdomyolysis 32.75 9.75 176 157701 51080 90419490
Foreign body aspiration 32.69 9.75 13 157864 216 90470354
Factor V inhibition 32.65 9.75 12 157865 159 90470411
Weight bearing difficulty 32.54 9.75 32 157845 2824 90467746
Ear canal erythema 32.48 9.75 9 157868 43 90470527
Red blood cell sedimentation rate increased 32.31 9.75 59 157818 82536 90388034
Gastroenteritis staphylococcal 32.16 9.75 10 157867 76 90470494
Gastroenteritis pseudomonas 32.13 9.75 6 157871 0 90470570
Confusional state 31.52 9.75 478 157399 385727 90084843
Lividity 31.42 9.75 15 157862 394 90470176
Chills 31.39 9.75 360 157517 131621 90338949
Anorectal ulcer 31.36 9.75 9 157868 50 90470520
Exercise tolerance decreased 31.27 9.75 51 157826 7500 90463070
Collagen disorder 31.14 9.75 13 157864 246 90470324
Renal tubular injury 31.08 9.75 22 157855 1227 90469343
Non-consummation 30.91 9.75 9 157868 53 90470517
Nephropathy toxic 30.53 9.75 68 157809 12620 90457950
Mouth ulceration 30.27 9.75 144 157733 39830 90430740
Colitis ulcerative 30.13 9.75 194 157683 60072 90410498
Acute hepatic failure 29.95 9.75 97 157780 22464 90448106
Underdose 29.82 9.75 30 157847 53987 90416583
Dysaesthesia 29.63 9.75 41 157836 5214 90465356
Chest pain 29.42 9.75 747 157130 318898 90151672
Biliary dyskinesia 29.39 9.75 29 157848 2570 90468000
Hyperacusis 29.28 9.75 30 157847 2781 90467789
Phlebitis 29.18 9.75 49 157828 7381 90463189
Cholestasis 29.14 9.75 133 157744 36166 90434404
Electrocardiogram QT prolonged 29.04 9.75 221 157656 72235 90398335
Infection 28.91 9.75 450 157427 361644 90108926
Anaemia 28.89 9.75 812 157065 351990 90118580
Cystic fibrosis 28.88 9.75 35 157842 3906 90466664
Photosensitivity reaction 28.74 9.75 82 157795 17725 90452845
Muscle twitching 28.54 9.75 100 157777 24102 90446468
Vulvovaginal pruritus 28.51 9.75 35 157842 3958 90466612
Haemolytic anaemia 28.49 9.75 63 157814 11634 90458936
Muscle contractions involuntary 28.26 9.75 30 157847 2898 90467672
Palpitations 28.19 9.75 363 157514 136365 90334205
Finger deformity 28.16 9.75 11 157866 32886 90437684
Nutritional supplementation 28.09 9.75 8 157869 43 90470527
Haematuria 28.04 9.75 128 157749 34809 90435761
Dermatitis bullous 27.93 9.75 58 157819 10258 90460312
Depersonalisation/derealisation disorder 27.93 9.75 23 157854 1609 90468961
Memory impairment 27.85 9.75 215 157662 197029 90273541
Bacterial infection 27.76 9.75 97 157780 23347 90447223
Bladder hypertrophy 27.61 9.75 15 157862 520 90470050
Liver disorder 27.58 9.75 113 157764 121156 90349414
Hepatitis infectious mononucleosis 27.52 9.75 10 157867 128 90470442
Potentiating drug interaction 27.28 9.75 41 157836 5621 90464949
Haematoma 26.96 9.75 137 157740 38911 90431659
Moraxella test positive 26.89 9.75 7 157870 25 90470545
Sinobronchitis 26.39 9.75 16 157861 685 90469885
Bladder pain 26.34 9.75 28 157849 2709 90467861
Injection site pruritus 26.33 9.75 33 157844 53801 90416769
Immunodeficiency 26.25 9.75 22 157855 43212 90427358
Raoultella ornithinolytica infection 26.16 9.75 9 157868 97 90470473
Anaphylactic reaction 26.12 9.75 250 157627 87274 90383296
Loss of personal independence in daily activities 26.10 9.75 135 157742 135970 90334600
Encephalopathy 26.05 9.75 154 157723 46290 90424280
Inflammation 26.01 9.75 193 157684 178399 90292171
Injection site swelling 25.94 9.75 40 157837 59799 90410771
Renal injury 25.90 9.75 56 157821 10187 90460383
Renal impairment 25.72 9.75 289 157588 105132 90365438
Therapeutic product effect incomplete 25.70 9.75 215 157662 193681 90276889
Disability 25.65 9.75 20 157857 40725 90429845
Injection site bruising 25.65 9.75 32 157845 52275 90418295
Myopathy 25.57 9.75 66 157811 13452 90457118
Rectal tube insertion 25.56 9.75 6 157871 12 90470558
Feeding intolerance 25.55 9.75 18 157859 996 90469574
Face oedema 25.50 9.75 94 157783 23224 90447346
Escherichia infection 25.46 9.75 73 157804 15822 90454748
Rectal abscess 25.38 9.75 21 157856 1479 90469091
Cross sensitivity reaction 25.35 9.75 28 157849 2829 90467741
Gallbladder rupture 25.19 9.75 14 157863 508 90470062
Adverse drug reaction 25.15 9.75 111 157766 116590 90353980
Diaphragmatic rupture 25.04 9.75 11 157866 237 90470333
Heart rate decreased 24.79 9.75 169 157708 53336 90417234
Electrolyte imbalance 24.54 9.75 94 157783 23651 90446919
Bacteraemia 24.47 9.75 90 157787 22210 90448360
Rotator cuff syndrome 24.43 9.75 72 157805 15847 90454723
COVID-19 24.33 9.75 183 157694 168660 90301910
Musculoskeletal pain 24.02 9.75 187 157690 171064 90299506
Epicondylitis 24.02 9.75 26 157851 2568 90468002
Chemical burns of eye 23.97 9.75 8 157869 78 90470492
Nerve injury 23.94 9.75 57 157820 11049 90459521
Laryngitis 23.90 9.75 32 157845 50721 90419849
Acinetobacter infection 23.82 9.75 23 157854 1985 90468585
Enterococcal infection 23.43 9.75 53 157824 9938 90460632
Tendon necrosis 23.32 9.75 5 157872 5 90470565
Large intestine erosion 23.23 9.75 9 157868 139 90470431
Linear IgA disease 23.20 9.75 24 157853 2250 90468320
Bone marrow granuloma 23.14 9.75 6 157871 21 90470549
Intestinal dilatation 22.88 9.75 24 157853 2286 90468284
Basal cell carcinoma 22.84 9.75 15 157862 33374 90437196
Genital paraesthesia 22.71 9.75 6 157871 23 90470547
Botulism 22.70 9.75 11 157866 299 90470271
Device related infection 22.60 9.75 97 157780 25689 90444881
Vaccination complication 22.60 9.75 17 157860 1042 90469528
Herpes simplex colitis 22.48 9.75 8 157869 96 90470474
Product dose omission issue 22.44 9.75 365 157512 291322 90179248
Activated partial thromboplastin time prolonged 22.38 9.75 45 157832 7780 90462790
Confabulation 22.36 9.75 11 157866 309 90470261
Back injury 22.36 9.75 29 157848 46593 90423977
Mineral deficiency 22.31 9.75 7 157870 55 90470515
Breast cancer 22.30 9.75 37 157840 53724 90416846
Infective aneurysm 21.83 9.75 12 157865 426 90470144
Anhedonia 21.82 9.75 56 157821 11375 90459195
Single functional kidney 21.70 9.75 11 157866 330 90470240
Osteochondrosis 21.65 9.75 21 157856 1822 90468748
Injection site hyperaesthesia 21.57 9.75 7 157870 62 90470508
Vaccination site reaction 21.51 9.75 10 157867 247 90470323
Tendon laxity 21.42 9.75 4 157873 0 90470570
Normal newborn 21.38 9.75 7 157870 23355 90447215
Cytokine release syndrome 21.35 9.75 101 157776 27872 90442698
Tonsillar haemorrhage 21.22 9.75 10 157867 255 90470315
Rhinalgia 21.18 9.75 24 157853 2494 90468076
Drug level below therapeutic 21.07 9.75 37 157840 5777 90464793
Respiratory tract oedema 21.00 9.75 14 157863 708 90469862
Product dose omission in error 20.89 9.75 5 157872 20498 90450072
Fixed eruption 20.87 9.75 20 157857 1710 90468860
Meningitis candida 20.82 9.75 7 157870 70 90470500
Escherichia urinary tract infection 20.74 9.75 62 157815 13753 90456817
Tinea versicolour 20.63 9.75 8 157869 124 90470446
Diabetic macroangiopathy 20.57 9.75 8 157869 125 90470445
Acute febrile neutrophilic dermatosis 20.50 9.75 28 157849 3517 90467053
Product contamination microbial 20.49 9.75 10 157867 276 90470294
Eyelid oedema 20.48 9.75 55 157822 11479 90459091
Dehydration 20.48 9.75 463 157414 193984 90276586
Polyneuropathy 20.34 9.75 77 157800 19264 90451306
Myelosuppression 20.32 9.75 39 157838 53552 90417018
Hepatic cytolysis 20.32 9.75 107 157770 30809 90439761
Hepatotoxicity 20.18 9.75 143 157734 45699 90424871
Rash scarlatiniform 20.03 9.75 9 157868 205 90470365
Anorectal disorder 19.94 9.75 21 157856 2010 90468560
Subcutaneous abscess 19.86 9.75 39 157838 6627 90463943
Tremor 19.83 9.75 376 157501 152797 90317773
Proctalgia 19.80 9.75 44 157833 8154 90462416
Leukopenia 19.76 9.75 265 157612 100445 90370125
Allergy to animal 19.72 9.75 19 157858 1635 90468935
Purple glove syndrome 19.71 9.75 9 157868 213 90470357
Procedural pain 19.61 9.75 112 157765 33248 90437322
Neuralgia 19.34 9.75 107 157770 31393 90439177
Medical device site pain 19.22 9.75 9 157868 226 90470344
Toxic encephalopathy 19.14 9.75 45 157832 8654 90461916
Long QT syndrome 19.12 9.75 29 157848 4008 90466562
Restlessness 19.11 9.75 117 157760 35603 90434967
Fat tissue decreased 19.10 9.75 7 157870 92 90470478
Jaundice 19.00 9.75 109 157768 32408 90438162
Drug tolerance 19.00 9.75 4 157873 17912 90452658
Coma 18.92 9.75 64 157813 72568 90398002
Vitreous floaters 18.77 9.75 41 157836 7508 90463062
Documented hypersensitivity to administered product 18.75 9.75 13 157864 701 90469869
Roseola 18.65 9.75 4 157873 4 90470566
Enterocutaneous fistula 18.61 9.75 18 157859 1556 90469014
Aural polyp 18.58 9.75 8 157869 164 90470406
Infusion site streaking 18.57 9.75 12 157865 575 90469995
Medication error 18.56 9.75 80 157797 84572 90385998
Systemic candida 18.54 9.75 32 157845 4927 90465643
Plasmapheresis 18.50 9.75 10 157867 343 90470227
Enterocolonic fistula 18.41 9.75 6 157871 54 90470516
Bladder trabeculation 18.41 9.75 6 157871 54 90470516
Condition aggravated 18.37 9.75 849 157028 594696 89875874
Hypercreatininaemia 18.13 9.75 13 157864 740 90469830
Paranasal sinus discomfort 18.10 9.75 36 157841 6174 90464396
Muscle tightness 18.03 9.75 58 157819 13381 90457189
Seroconversion test positive 18.03 9.75 5 157872 24 90470546
Postural orthostatic tachycardia syndrome 18.00 9.75 21 157856 2251 90468319
Feeling of body temperature change 18.00 9.75 34 157843 5615 90464955
Femur fracture 17.95 9.75 33 157844 46049 90424521
Injury 17.93 9.75 239 157638 197110 90273460
Agranulocytosis 17.70 9.75 113 157764 34889 90435681
Colonic abscess 17.68 9.75 16 157861 1272 90469298
Vascular access site pain 17.65 9.75 11 157866 495 90470075
Urine odour abnormal 17.63 9.75 39 157838 7205 90463365
Sensory disturbance 17.59 9.75 63 157814 15350 90455220
Haemorrhage urinary tract 17.58 9.75 15 157862 1102 90469468
Haematocrit decreased 17.56 9.75 129 157748 41703 90428867
Bulimia nervosa 17.49 9.75 11 157866 503 90470067
Gallbladder injury 17.49 9.75 16 157861 1290 90469280
Enterobiasis 17.46 9.75 7 157870 119 90470451
Foetal exposure during pregnancy 17.44 9.75 30 157847 42945 90427625
Product label confusion 17.43 9.75 9 157868 22841 90447729
Disturbance in sexual arousal 17.37 9.75 9 157868 283 90470287
Abscess intestinal 17.29 9.75 19 157858 1909 90468661
Nerve degeneration 17.25 9.75 6 157871 67 90470503
Generalised tonic-clonic seizure 17.23 9.75 112 157765 34791 90435779
Thrombotic thrombocytopenic purpura 17.20 9.75 28 157849 4110 90466460
Product substitution issue 17.19 9.75 5 157872 18003 90452567
Hyperchlorhydria 17.18 9.75 19 157858 1922 90468648
Skin oedema 17.16 9.75 15 157862 1139 90469431
Extremity necrosis 17.05 9.75 19 157858 1938 90468632
Macular degeneration 17.04 9.75 119 157758 37851 90432719
Rash pustular 17.02 9.75 41 157836 8008 90462562
Ototoxicity 17.00 9.75 19 157858 1945 90468625
Labelled drug-drug interaction medication error 16.98 9.75 60 157817 14522 90456048
Muscle rupture 16.96 9.75 24 157853 3117 90467453
Antimicrobial susceptibility test intermediate 16.96 9.75 5 157872 31 90470539
Type IV hypersensitivity reaction 16.92 9.75 27 157850 3899 90466671
Back disorder 16.89 9.75 12 157865 25619 90444951
Drug level decreased 16.88 9.75 46 157831 9684 90460886
Enterovesical fistula 16.86 9.75 12 157865 675 90469895
Cholecystitis acute 16.86 9.75 45 157832 9359 90461211
Toxic neuropathy 16.84 9.75 11 157866 537 90470033
Intrauterine infection 16.74 9.75 7 157870 133 90470437
Renal vein compression 16.72 9.75 4 157873 9 90470561
Neurotransmitter level altered 16.72 9.75 4 157873 9 90470561
Pleural neoplasm 16.64 9.75 10 157867 421 90470149
Constipation 16.60 9.75 621 157256 279774 90190796
Bacteriuria 16.59 9.75 15 157862 1191 90469379
Limb immobilisation 16.57 9.75 6 157871 76 90470494
Factor XIII Inhibition 16.56 9.75 5 157872 34 90470536
Injection site streaking 16.56 9.75 5 157872 34 90470536
Plantar fasciitis 16.54 9.75 28 157849 4246 90466324
Fear 16.52 9.75 65 157812 16557 90454013
Injection site warmth 16.47 9.75 5 157872 17510 90453060
Sphingomonas paucimobilis infection 16.43 9.75 6 157871 78 90470492
Hypotony of eye 16.42 9.75 8 157869 220 90470350
Ballismus 16.41 9.75 7 157870 140 90470430
Red blood cell sedimentation rate abnormal 16.39 9.75 11 157866 24193 90446377
Leukocyturia 16.33 9.75 17 157860 1605 90468965
Hepatic encephalopathy 16.32 9.75 57 157820 13715 90456855
Colitis ischaemic 16.31 9.75 53 157824 12293 90458277
Delayed graft function 16.30 9.75 16 157861 1409 90469161
Faeces discoloured 16.29 9.75 77 157800 21243 90449327
Gastrointestinal scarring 16.27 9.75 10 157867 439 90470131
Hepatocellular injury 16.22 9.75 96 157781 28862 90441708
Perineal pain 16.22 9.75 11 157866 572 90469998
Cholestatic liver injury 16.21 9.75 26 157851 3771 90466799
Ligament disorder 16.14 9.75 10 157867 445 90470125
Skin warm 16.08 9.75 39 157838 7648 90462922
Thinking abnormal 16.08 9.75 51 157826 11681 90458889
Skin test positive 16.07 9.75 13 157864 887 90469683
Injection site joint erythema 16.06 9.75 3 157874 0 90470570
Peripheral artery dissection 16.06 9.75 3 157874 0 90470570
Haemolytic uraemic syndrome 15.95 9.75 22 157855 2789 90467781
Odynophagia 15.93 9.75 43 157834 9000 90461570
Staphylococcal scalded skin syndrome 15.93 9.75 7 157870 151 90470419
Serratia infection 15.93 9.75 14 157863 1071 90469499
Mesenteritis 15.91 9.75 9 157868 338 90470232
Eczema asteatotic 15.86 9.75 9 157868 340 90470230
Acute psychosis 15.86 9.75 23 157854 3055 90467515
Dermatitis exfoliative generalised 15.80 9.75 32 157845 5561 90465009
Panic reaction 15.79 9.75 29 157848 4688 90465882
Vaginal infection 15.75 9.75 41 157836 8399 90462171
Paraesthesia 15.69 9.75 558 157319 249768 90220802
Gastrointestinal wall thickening 15.69 9.75 19 157858 2118 90468452
Vulvovaginal candidiasis 15.69 9.75 26 157851 3874 90466696
Burnout syndrome 15.66 9.75 8 157869 244 90470326
Walking disability 15.65 9.75 16 157861 1479 90469091
Eye swelling 15.56 9.75 96 157781 29290 90441280
Carcinoembryonic antigen 15.53 9.75 6 157871 92 90470478
Gallbladder disorder 15.48 9.75 72 157805 19731 90450839
Dermatitis atopic 15.45 9.75 11 157866 23461 90447109
Product deposit 15.44 9.75 9 157868 358 90470212
Cytomegalovirus infection 15.43 9.75 89 157788 26513 90444057
Head injury 15.37 9.75 19 157858 31169 90439401
Skin injury 15.33 9.75 19 157858 2169 90468401
Vulvovaginal swelling 15.28 9.75 12 157865 784 90469786
Ear infection 15.26 9.75 66 157811 69709 90400861
Ulcer haemorrhage 15.25 9.75 14 157863 26307 90444263
Productive cough 15.21 9.75 203 157674 76860 90393710
Idiosyncratic drug reaction 15.20 9.75 13 157864 958 90469612
Skin plaque 15.20 9.75 45 157832 9930 90460640
Carbohydrate antigen 15-3 15.18 9.75 6 157871 98 90470472
Corneal deposits 15.15 9.75 9 157868 371 90470199
Immune reconstitution inflammatory syndrome 15.10 9.75 36 157841 6983 90463587
Aortic rupture 15.07 9.75 6 157871 100 90470470
Papule 15.07 9.75 39 157838 7963 90462607
Nephrolithiasis 15.04 9.75 141 157736 48944 90421626
Mycobacterium chelonae infection 15.04 9.75 11 157866 646 90469924
Diabetes mellitus 15.03 9.75 60 157817 64815 90405755
Calculus bladder 14.98 9.75 11 157866 650 90469920
Faecal volume decreased 14.98 9.75 8 157869 268 90470302
Poisoning 14.95 9.75 4 157873 15213 90455357
Peritonitis 14.93 9.75 71 157806 19634 90450936
Haemorrhagic vasculitis 14.91 9.75 6 157871 103 90470467
Hypersensitivity 14.86 9.75 644 157233 454033 90016537
Post infection glomerulonephritis 14.82 9.75 4 157873 17 90470553
Erythema multiforme 14.79 9.75 51 157826 12195 90458375
Renal papillary necrosis 14.76 9.75 8 157869 276 90470294
Chronic lymphocytic leukaemia recurrent 14.74 9.75 9 157868 390 90470180
Vulval abscess 14.74 9.75 13 157864 999 90469571
Clostridium colitis 14.72 9.75 18 157859 2027 90468543
Migraine 14.71 9.75 238 157639 190154 90280416
Neutrophilic dermatosis 14.71 9.75 8 157869 278 90470292
Histamine intolerance 14.70 9.75 5 157872 52 90470518
Visual snow syndrome 14.70 9.75 5 157872 52 90470518
Systemic inflammatory response syndrome 14.65 9.75 34 157843 6482 90464088
Leuconostoc infection 14.63 9.75 4 157873 18 90470552
Recall phenomenon 14.60 9.75 12 157865 837 90469733
Foetal death 14.60 9.75 9 157868 20714 90449856
Tuberculosis gastrointestinal 14.60 9.75 9 157868 397 90470173
Neurotoxicity 14.60 9.75 75 157802 21392 90449178
Lymphadenitis 14.57 9.75 26 157851 4111 90466459
Toxic leukoencephalopathy 14.55 9.75 12 157865 841 90469729
Hyperpathia 14.45 9.75 4 157873 19 90470551
May-Thurner syndrome 14.44 9.75 5 157872 55 90470515
Hypoglossal nerve paresis 14.40 9.75 6 157871 113 90470457
Iatrogenic injury 14.37 9.75 12 157865 856 90469714
Bone erosion 14.30 9.75 46 157831 52975 90417595
Diarrhoea haemorrhagic 14.29 9.75 46 157831 10617 90459953
Anal paraesthesia 14.29 9.75 4 157873 20 90470550
Persistent corneal epithelial defect 14.29 9.75 4 157873 20 90470550
Tachypnoea 14.18 9.75 74 157803 21235 90449335
Gastric disorder 14.04 9.75 103 157774 33281 90437289
Muscle spasticity 14.02 9.75 25 157852 35297 90435273
Folate deficiency 13.96 9.75 22 157855 3143 90467427
Muscle spasms 13.96 9.75 333 157544 251550 90219020
Kidney infection 13.93 9.75 85 157792 25831 90444739
Enzyme level abnormal 13.89 9.75 8 157869 311 90470259
Complex regional pain syndrome 13.89 9.75 20 157857 2639 90467931
Refractory anaemia with an excess of blasts 13.88 9.75 9 157868 434 90470136
Ileostomy 13.75 9.75 17 157860 1937 90468633
Blood disorder 13.68 9.75 37 157840 7753 90462817
Multiple sclerosis relapse 13.68 9.75 46 157831 52259 90418311
Vascular purpura 13.67 9.75 16 157861 1722 90468848
Lip oedema 13.65 9.75 27 157850 4612 90465958
Therapy partial responder 13.65 9.75 11 157866 22032 90448538
Drug level increased 13.65 9.75 89 157788 27673 90442897
Spinal fracture 13.62 9.75 11 157866 22005 90448565
Device malfunction 13.59 9.75 10 157867 20967 90449603
Burning mouth syndrome 13.58 9.75 10 157867 593 90469977
Throat tightness 13.58 9.75 93 157784 29391 90441179
Hydronephrosis 13.56 9.75 50 157827 12352 90458218
Sensory processing disorder 13.54 9.75 4 157873 25 90470545
Fungal sepsis 13.49 9.75 15 157862 1526 90469044
Leukaemoid reaction 13.34 9.75 7 157870 226 90470344
Dysphagia 13.31 9.75 272 157605 112006 90358564
Abscess fungal 13.23 9.75 5 157872 72 90470498
Transmission of an infectious agent via product 13.22 9.75 6 157871 140 90470430
Abdominal tenderness 13.21 9.75 41 157836 9283 90461287
Blood creatine increased 13.16 9.75 34 157843 6933 90463637
Neutropenic infection 13.15 9.75 16 157861 1793 90468777
Norovirus test positive 13.06 9.75 7 157870 236 90470334
Quadriparesis 13.06 9.75 19 157858 2530 90468040
Fasciitis 13.04 9.75 10 157867 631 90469939
Pulmonary function test decreased 13.04 9.75 26 157851 4468 90466102
Portal fibrosis 13.04 9.75 8 157869 350 90470220
Acid base balance abnormal 13.00 9.75 8 157869 352 90470218
Gastrointestinal inflammation 12.98 9.75 33 157844 6663 90463907
Endocarditis bacterial 12.98 9.75 10 157867 635 90469935
Herpes zoster 12.96 9.75 104 157773 94540 90376030
Malignant melanoma 12.94 9.75 3 157874 12573 90457997
Hearing disability 12.91 9.75 4 157873 30 90470540
Peritoneal adhesions 12.90 9.75 7 157870 242 90470328
Aphthous ulcer 12.89 9.75 62 157815 17225 90453345
Photophobia 12.89 9.75 72 157805 21197 90449373
Hemiplegia 12.88 9.75 6 157871 16154 90454416
Rectal haemorrhage 12.81 9.75 209 157668 82535 90388035
Metastases to kidney 12.80 9.75 7 157870 246 90470324
Lower respiratory tract infection bacterial 12.78 9.75 9 157868 498 90470072
Personality disorder 12.75 9.75 3 157874 12441 90458129
Mitochondrial toxicity 12.74 9.75 10 157867 653 90469917
Tongue geographic 12.73 9.75 6 157871 153 90470417
Breast cancer female 12.70 9.75 5 157872 14881 90455689
Injection site rash 12.70 9.75 14 157863 24159 90446411
Mitochondrial enzyme deficiency 12.69 9.75 4 157873 32 90470538
Allodynia 12.66 9.75 12 157865 1012 90469558
Pyuria 12.66 9.75 17 157860 2102 90468468
International normalised ratio increased 12.59 9.75 132 157745 47184 90423386
Conjunctival hyperaemia 12.58 9.75 21 157856 3148 90467422
Hypertensive heart disease 12.55 9.75 19 157858 2621 90467949
Post viral fatigue syndrome 12.54 9.75 7 157870 256 90470314
Rash morbilliform 12.53 9.75 24 157853 4005 90466565
Breath odour 12.49 9.75 14 157863 1437 90469133
Exfoliative rash 12.47 9.75 21 157856 3171 90467399
Cardio-respiratory arrest 12.46 9.75 62 157815 63078 90407492
Injection site urticaria 12.45 9.75 8 157869 18003 90452567
Increased bronchial secretion 12.44 9.75 17 157860 2136 90468434
Diarrhoea infectious 12.41 9.75 13 157864 1236 90469334
Self-injurious ideation 12.41 9.75 21 157856 3182 90467388
Mucous stools 12.40 9.75 28 157849 5243 90465327
Bladder catheterisation 12.35 9.75 8 157869 385 90470185
Intentional self-injury 12.34 9.75 20 157857 29314 90441256
Illusion 12.29 9.75 13 157864 1251 90469319
Oesophagitis 12.24 9.75 61 157816 17188 90453382
Vaginal abscess 12.24 9.75 9 157868 533 90470037
Derealisation 12.23 9.75 14 157863 1471 90469099
Urethral pain 12.22 9.75 8 157869 392 90470178
Deafness bilateral 12.21 9.75 15 157862 1698 90468872
Staphylococcal sepsis 12.14 9.75 40 157837 9343 90461227
Petechiae 12.13 9.75 57 157820 15684 90454886
Pulmonary hypertension 12.10 9.75 36 157841 42487 90428083
Respiratory gas exchange disorder 12.06 9.75 8 157869 401 90470169
Drug eruption 12.02 9.75 104 157773 35303 90435267
Cardiovascular disorder 12.02 9.75 51 157826 13441 90457129
Sense of oppression 11.93 9.75 12 157865 1088 90469482
Histamine abnormal 11.92 9.75 3 157874 9 90470561
Somatic dysfunction 11.92 9.75 3 157874 9 90470561
Large intestinal stenosis 11.92 9.75 18 157859 2479 90468091
Paranasal sinus hyposecretion 11.87 9.75 6 157871 179 90470391
Pseudomonas test positive 11.83 9.75 11 157866 905 90469665
Deficiency of bile secretion 11.81 9.75 4 157873 41 90470529
Insomnia 11.81 9.75 468 157409 333006 90137564
Joint dislocation 11.80 9.75 39 157838 44543 90426027
Inappropriate antidiuretic hormone secretion 11.80 9.75 66 157811 19439 90451131
Upper respiratory tract infection 11.80 9.75 155 157722 128163 90342407
Injection site eczema 11.77 9.75 5 157872 99 90470471
Gastrointestinal infection 11.76 9.75 44 157833 10946 90459624
Vision blurred 11.72 9.75 263 157614 110030 90360540
Graft versus host disease 11.71 9.75 36 157841 8108 90462462
Angiopathy 11.68 9.75 28 157849 5452 90465118
Gastrointestinal sounds abnormal 11.67 9.75 25 157852 4518 90466052
Paranoia 11.66 9.75 49 157828 12859 90457711
Periorbital oedema 11.65 9.75 32 157845 6767 90463803
Choriocarcinoma 11.64 9.75 4 157873 43 90470527
Skin burning sensation 11.63 9.75 66 157811 19545 90451025
Retinal detachment 11.58 9.75 32 157845 6790 90463780
Genital pain 11.57 9.75 10 157867 748 90469822
Oesophageal candidiasis 11.56 9.75 32 157845 6797 90463773
Urine viscosity increased 11.56 9.75 4 157873 44 90470526
Biopsy colon abnormal 11.54 9.75 5 157872 104 90470466
Prurigo 11.54 9.75 11 157866 934 90469636
Chronic fatigue syndrome 11.53 9.75 14 157863 1565 90469005
Drug abuse 11.50 9.75 90 157787 82257 90388313
Intermittent claudication 11.46 9.75 15 157862 1808 90468762
Product storage error 11.45 9.75 11 157866 20230 90450340
Herpes simplex hepatitis 11.45 9.75 9 157868 589 90469981
Vanishing bile duct syndrome 11.41 9.75 13 157864 1359 90469211
Autoimmune thyroiditis 11.38 9.75 29 157848 5864 90464706
Ventricular arrhythmia 11.36 9.75 24 157853 4297 90466273
Hormone level abnormal 11.35 9.75 19 157858 2854 90467716
Hypomagnesaemia 11.29 9.75 103 157774 35485 90435085
Proctitis herpes 11.26 9.75 3 157874 12 90470558
Ligament rupture 11.26 9.75 22 157855 3726 90466844
Therapy interrupted 11.20 9.75 47 157830 50061 90420509
Allergic sinusitis 11.19 9.75 16 157861 2097 90468473
Eye pain 11.19 9.75 122 157755 44046 90426524
Fear of death 11.17 9.75 12 157865 1175 90469395
Human ehrlichiosis 11.15 9.75 6 157871 204 90470366
Episcleritis 11.14 9.75 12 157865 1178 90469392
Intentional product misuse 11.13 9.75 101 157776 89503 90381067
Keratitis bacterial 11.09 9.75 4 157873 50 90470520
Injection site thrombosis 11.08 9.75 5 157872 115 90470455
Levator syndrome 11.06 9.75 3 157874 13 90470557
Neoplasm progression 11.05 9.75 40 157837 44446 90426124
Gastrointestinal mucosa hyperaemia 11.02 9.75 6 157871 209 90470361
Dialysis 11.02 9.75 44 157833 11285 90459285
Thyroxine increased 10.97 9.75 10 157867 802 90469768
Hospitalisation 10.96 9.75 157 157720 127943 90342627
Female reproductive tract disorder 10.96 9.75 9 157868 627 90469943
Haemodynamic instability 10.94 9.75 45 157832 11694 90458876
Lymphadenopathy 10.94 9.75 125 157752 45650 90424920
Maternal exposure before pregnancy 10.91 9.75 3 157874 11210 90459360
Lip swelling 10.89 9.75 109 157768 38501 90432069
Hypersensitivity vasculitis 10.82 9.75 23 157854 4136 90466434
Papillitis 10.82 9.75 4 157873 54 90470516
Illness 10.80 9.75 91 157786 81878 90388692
Inflammatory marker increased 10.80 9.75 38 157839 9176 90461394
Breast discomfort 10.77 9.75 9 157868 643 90469927
Abdominal wall disorder 10.74 9.75 6 157871 220 90470350
Cerebrovascular accident 10.72 9.75 151 157726 123382 90347188
Glossitis 10.71 9.75 21 157856 3566 90467004
Sinus disorder 10.67 9.75 28 157849 34419 90436151
Acute myeloid leukaemia 10.66 9.75 67 157810 20573 90449997
Paraneoplastic syndrome 10.62 9.75 9 157868 655 90469915
Meningitis bacterial 10.60 9.75 14 157863 1703 90468867
Abscess drainage 10.60 9.75 9 157868 657 90469913
Coma hepatic 10.60 9.75 9 157868 657 90469913
Dysphoria 10.58 9.75 29 157848 6125 90464445
Agitation 10.58 9.75 170 157707 66928 90403642
Meniscus injury 10.56 9.75 35 157842 8202 90462368
Intestinal obstruction 10.56 9.75 105 157772 37026 90433544
Iatrogenic infection 10.55 9.75 3 157874 16 90470554
Streptococcal bacteraemia 10.55 9.75 16 157861 2211 90468359
Viral haemorrhagic cystitis 10.52 9.75 13 157864 1480 90469090
Cerebral amyloid angiopathy 10.50 9.75 6 157871 230 90470340
Anal skin tags 10.44 9.75 9 157868 671 90469899
Bacterial test positive 10.43 9.75 27 157850 5512 90465058
Myosclerosis 10.38 9.75 6 157871 235 90470335
Chromaturia 10.36 9.75 63 157814 19124 90451446
Physical disability 10.33 9.75 22 157855 3959 90466611
SAPHO syndrome 10.31 9.75 5 157872 136 90470434
Rash macular 10.31 9.75 89 157788 30191 90440379
Body temperature fluctuation 10.29 9.75 16 157861 2259 90468311
Proteus infection 10.29 9.75 13 157864 1513 90469057
Renal disorder 10.26 9.75 106 157771 37753 90432817
Red blood cell schistocytes present 10.26 9.75 7 157870 368 90470202
Panic disorder 10.24 9.75 19 157858 3096 90467474
Excessive granulation tissue 10.21 9.75 10 157867 878 90469692
Bovine tuberculosis 10.20 9.75 4 157873 64 90470506
Diverticulum 10.18 9.75 45 157832 12068 90458502
Hypoperfusion 10.18 9.75 14 157863 1770 90468800
Trichosporon infection 10.16 9.75 7 157870 374 90470196
Cranial nerve disorder 10.13 9.75 9 157868 698 90469872
Acute respiratory distress syndrome 10.13 9.75 85 157792 28601 90441969
Osteomyelitis 10.09 9.75 83 157794 27763 90442807
Clostridium bacteraemia 10.09 9.75 6 157871 248 90470322
Hyperinsulinaemia 10.08 9.75 5 157872 143 90470427
C-reactive protein decreased 10.08 9.75 11 157866 1096 90469474
Inhibitory drug interaction 10.03 9.75 19 157858 3144 90467426
Posterior reversible encephalopathy syndrome 10.02 9.75 70 157807 22269 90448301
Corneal opacity 10.00 9.75 10 157867 901 90469669
Gestational diabetes 9.99 9.75 3 157874 10579 90459991
Vulvovaginal pain 9.96 9.75 20 157857 3454 90467116
Proteus test positive 9.96 9.75 7 157870 386 90470184
Depressed level of consciousness 9.96 9.75 80 157797 72704 90397866
Abdominal abscess 9.88 9.75 26 157851 5361 90465209
Renal tubular disorder 9.84 9.75 19 157858 3188 90467382
Intestinal resection 9.80 9.75 18 157859 2909 90467661
Peripheral nerve injury 9.79 9.75 9 157868 730 90469840
Chorea 9.77 9.75 15 157862 2095 90468475
Ureteric injury 9.77 9.75 4 157873 72 90470498
Induration 9.76 9.75 13 157864 1594 90468976

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tendon pain 735.83 10.35 288 109344 3012 42508691
Tendonitis 684.19 10.35 384 109248 9510 42502193
Tendon rupture 516.58 10.35 298 109334 7785 42503918
Tendon disorder 337.89 10.35 168 109464 3221 42508482
Pathogen resistance 276.48 10.35 232 109400 11218 42500485
Death 239.96 10.35 537 109095 470648 42041055
Toxic epidermal necrolysis 236.34 10.35 317 109315 26433 42485270
Tendon discomfort 213.02 10.35 66 109566 314 42511389
Drug reaction with eosinophilia and systemic symptoms 208.35 10.35 382 109250 41693 42470010
Drug interaction 192.92 10.35 1260 108372 265739 42245964
Drug resistance 168.35 10.35 310 109322 33938 42477765
Drug hypersensitivity 157.07 10.35 587 109045 98802 42412901
Clostridium difficile colitis 156.72 10.35 231 109401 21021 42490682
Drug abuse 137.19 10.35 49 109583 104722 42406981
Completed suicide 129.95 10.35 43 109589 96422 42415281
Myalgia 129.60 10.35 540 109092 95540 42416163
Night sweats 119.28 10.35 197 109435 19772 42491931
Tubulointerstitial nephritis 115.97 10.35 253 109379 31295 42480408
Myocardial infarction 112.83 10.35 92 109540 123917 42387786
Choroiditis 107.79 10.35 58 109574 1317 42510386
Muscle rupture 97.94 10.35 67 109565 2373 42509330
Product dose omission issue 94.65 10.35 157 109475 154208 42357495
Paraesthesia 92.17 10.35 404 109228 73055 42438648
Rash maculo-papular 89.46 10.35 255 109377 37248 42474455
Joint noise 86.20 10.35 45 109587 959 42510744
Dysbiosis 80.71 10.35 40 109592 761 42510942
Pseudomonas infection 79.32 10.35 145 109487 15778 42495925
Cutaneous vasculitis 79.25 10.35 93 109539 6767 42504936
Septic shock 78.13 10.35 452 109180 91220 42420483
Solar lentigo 77.04 10.35 36 109596 598 42511105
Fistula 76.42 10.35 98 109534 7814 42503889
Intentional overdose 74.62 10.35 20 109612 51436 42460267
Torsade de pointes 74.58 10.35 101 109531 8493 42503210
Dysplastic naevus 74.23 10.35 36 109596 652 42511051
Eye pain 73.62 10.35 146 109486 16884 42494819
Stevens-Johnson syndrome 70.56 10.35 168 109464 22010 42489693
Cerebrovascular accident 70.18 10.35 88 109544 97072 42414631
Clostridium difficile infection 69.25 10.35 169 109463 22490 42489213
Photodermatosis 67.94 10.35 35 109597 725 42510978
Arthralgia 65.47 10.35 811 108821 204427 42307276
Toxicity to various agents 65.43 10.35 335 109297 228801 42282902
Anal fissure 63.83 10.35 73 109559 5166 42506537
Injection site pain 63.11 10.35 35 109597 57763 42453940
Pseudomembranous colitis 62.58 10.35 57 109575 3076 42508627
Hyperacusis 62.01 10.35 36 109596 951 42510752
Panic attack 62.01 10.35 106 109526 10939 42500764
Acute kidney injury 60.89 10.35 1302 108330 366035 42145668
Fall 60.30 10.35 355 109277 234165 42277538
Overdose 60.01 10.35 112 109520 105152 42406551
Trichoglossia 59.83 10.35 26 109606 361 42511342
Tinnitus 58.83 10.35 186 109446 28752 42482951
Muscle twitching 58.32 10.35 107 109525 11673 42500030
Rash morbilliform 57.72 10.35 62 109570 4091 42507612
Wrong technique in product usage process 55.67 10.35 20 109612 42615 42469088
Intraocular pressure increased 54.91 10.35 75 109557 6358 42505345
Henoch-Schonlein purpura 54.88 10.35 45 109587 2105 42509598
Spinal muscular atrophy 54.85 10.35 25 109607 391 42511312
Hyperfibrinolysis 54.16 10.35 13 109619 16 42511687
Abdominal abscess 53.84 10.35 66 109566 5027 42506676
Tracheobronchomegaly 53.73 10.35 13 109619 17 42511686
Pyrexia 53.08 10.35 1357 108275 392685 42119018
Foetal exposure during pregnancy 52.59 10.35 28 109604 47283 42464420
Colitis 50.88 10.35 246 109386 46326 42465377
Photosensitivity reaction 50.28 10.35 105 109527 12597 42499106
Eosinophilia 49.98 10.35 192 109440 32707 42478996
Sputum increased 48.93 10.35 50 109582 3113 42508590
COVID-19 48.78 10.35 145 109487 115803 42395900
Candida infection 48.69 10.35 144 109488 21466 42490237
Asthma 47.59 10.35 54 109578 62260 42449443
Malignant neoplasm progression 46.01 10.35 135 109497 108265 42403438
Ependymoma 45.20 10.35 11 109621 15 42511688
Febrile neutropenia 45.03 10.35 699 108933 185004 42326699
Corynebacterium bacteraemia 44.95 10.35 16 109616 125 42511578
Toxic encephalopathy 44.79 10.35 71 109561 6882 42504821
Ligament pain 43.76 10.35 13 109619 52 42511651
Cardiac failure congestive 43.74 10.35 97 109535 85505 42426198
Foetal cardiac arrest 43.28 10.35 11 109621 20 42511683
Skin injury 43.15 10.35 43 109589 2598 42509105
Burning sensation 42.65 10.35 135 109497 20878 42490825
Tendon injury 42.54 10.35 29 109603 1021 42510682
Motor neurone disease 42.20 10.35 23 109609 536 42511167
Renal tubular necrosis 42.02 10.35 123 109509 18231 42493472
Inflammation 40.80 10.35 184 109448 33663 42478040
Intentional product misuse 40.71 10.35 60 109572 61840 42449863
Disease progression 39.84 10.35 212 109420 143444 42368259
Clostridium test positive 39.37 10.35 59 109573 5446 42506257
Pulmonary embolism 39.33 10.35 166 109466 119446 42392257
Condition aggravated 39.23 10.35 912 108720 259842 42251861
Acute generalised exanthematous pustulosis 38.74 10.35 75 109557 8520 42503183
Cardiac failure 37.85 10.35 144 109488 106712 42404991
Muscle atrophy 37.73 10.35 73 109559 8288 42503415
Factor V inhibition 37.35 10.35 16 109616 214 42511489
Anal fistula 36.70 10.35 61 109571 6152 42505551
Cross sensitivity reaction 36.48 10.35 32 109600 1643 42510060
Hepatitis cholestatic 36.33 10.35 79 109553 9745 42501958
Psoriasis 36.16 10.35 43 109589 48561 42463142
Abscess 36.05 10.35 99 109533 14149 42497554
Anal abscess 35.99 10.35 69 109563 7781 42503922
Linear IgA disease 35.77 10.35 35 109597 2068 42509635
Pelvic abscess 35.69 10.35 26 109606 1019 42510684
Prostatitis 35.12 10.35 60 109572 6188 42505515
Leukocytosis 34.69 10.35 160 109472 29548 42482155
Chronic obstructive pulmonary disease 34.35 10.35 69 109563 63045 42448658
Anuria 34.16 10.35 85 109547 11447 42500256
Blood glucose increased 34.09 10.35 88 109544 73611 42438092
Suicide attempt 34.07 10.35 41 109591 46059 42465644
Visual acuity reduced 34.03 10.35 111 109521 17439 42494264
Dyspnoea 33.75 10.35 874 108758 441747 42069956
Aortic valve prolapse 33.72 10.35 8 109624 9 42511694
Musculoskeletal injury 33.54 10.35 13 109619 132 42511571
Radiation inflammation 33.38 10.35 25 109607 1023 42510680
Fixed eruption 32.99 10.35 36 109596 2418 42509285
Stoma closure 32.88 10.35 16 109616 292 42511411
Yellow fever 32.27 10.35 7 109625 3 42511700
Diabetic ketoacidosis 31.85 10.35 9 109623 22358 42489345
Aspergillus infection 31.46 10.35 101 109531 15736 42495967
Accidental exposure to product 31.37 10.35 7 109625 20386 42491317
Off label use 31.31 10.35 1334 108298 637001 41874702
Pyelonephritis fungal 31.12 10.35 11 109621 84 42511619
Psoas abscess 31.05 10.35 22 109610 825 42510878
Somnolence 30.93 10.35 224 109408 140881 42370822
Coronary artery disease 30.74 10.35 57 109575 53663 42458040
Hospitalisation 30.50 10.35 94 109538 74236 42437467
Enterococcal infection 29.81 10.35 83 109549 11956 42499747
Metabolic disorder 29.62 10.35 48 109584 4740 42506963
Disease complication 29.60 10.35 38 109594 3032 42508671
Hypertension 29.59 10.35 281 109351 166923 42344780
Hyphaema 29.44 10.35 20 109612 700 42511003
Agranulocytosis 29.42 10.35 156 109476 30456 42481247
Necrotising retinitis 29.36 10.35 23 109609 1007 42510696
Walking aid user 29.26 10.35 35 109597 2598 42509105
Ischaemic cerebral infarction 29.17 10.35 28 109604 1615 42510088
Diastasis recti abdominis 29.17 10.35 10 109622 69 42511634
Urosepsis 29.12 10.35 95 109537 14925 42496778
Pancreatic enzyme abnormality 29.07 10.35 11 109621 104 42511599
Sphingomonas paucimobilis infection 29.02 10.35 9 109623 43 42511660
Crohn's disease 28.88 10.35 37 109595 2947 42508756
Pouchitis 28.81 10.35 22 109610 927 42510776
Escherichia infection 28.65 10.35 79 109553 11317 42500386
Thrombosis 28.57 10.35 86 109546 68425 42443278
Nosocomial infection 28.43 10.35 26 109606 1410 42510293
Chronic fatigue syndrome 28.26 10.35 15 109617 331 42511372
Pneumococcal sepsis 28.14 10.35 26 109606 1429 42510274
Vanishing bile duct syndrome 27.90 10.35 29 109603 1842 42509861
Undersensing 27.80 10.35 7 109625 12 42511691
Prostatic pain 27.74 10.35 15 109617 344 42511359
Nephritis allergic 27.67 10.35 19 109613 677 42511026
Urinary tract infection 27.27 10.35 382 109250 98902 42412801
Bone cyst 27.19 10.35 27 109605 1624 42510079
Anxiety 27.08 10.35 442 109190 118118 42393585
Deep vein thrombosis 27.05 10.35 104 109528 76853 42434850
Therapeutic product effect incomplete 26.83 10.35 93 109539 70846 42440857
Infective pulmonary exacerbation of cystic fibrosis 26.81 10.35 61 109571 7757 42503946
Cholestasis 26.61 10.35 160 109472 32719 42478984
Trichosporon infection 26.58 10.35 21 109611 931 42510772
Pulmonary pain 26.35 10.35 26 109606 1552 42510151
Lower respiratory tract infection bacterial 26.29 10.35 17 109615 547 42511156
Penis injury 26.29 10.35 13 109619 246 42511457
Coma 26.28 10.35 62 109570 53492 42458211
Abdominal pain 26.13 10.35 658 108974 189813 42321890
Geotrichum infection 25.94 10.35 17 109615 560 42511143
Pain in extremity 25.86 10.35 537 109095 150067 42361636
Myelosuppression 25.85 10.35 40 109592 40421 42471282
Chronic gastrointestinal bleeding 25.74 10.35 14 109618 325 42511378
Cystitis 25.45 10.35 77 109555 11621 42500082
Hypophosphataemia 25.41 10.35 11 109621 20934 42490769
COVID-19 pneumonia 25.20 10.35 12 109620 21601 42490102
Uveitis 25.10 10.35 66 109566 9192 42502511
Joint ankylosis 25.02 10.35 26 109606 1651 42510052
Aeromonas infection 24.95 10.35 14 109618 346 42511357
Yellow fever vaccine-associated viscerotropic disease 24.83 10.35 5 109627 0 42511703
Connective tissue disorder 24.82 10.35 13 109619 279 42511424
Megacolon 24.78 10.35 30 109602 2255 42509448
Incorrect route of product administration 24.72 10.35 16 109616 24289 42487414
Infective aneurysm 24.62 10.35 21 109611 1038 42510665
Phlebitis infective 24.32 10.35 10 109622 120 42511583
Hypoaesthesia 24.29 10.35 286 109346 71177 42440526
Increased bronchial secretion 24.15 10.35 30 109602 2316 42509387
Hypnagogic hallucination 24.14 10.35 8 109624 49 42511654
Electrocardiogram QT prolonged 24.08 10.35 208 109424 47737 42463966
Sopor 23.68 10.35 3 109629 13199 42498504
Device related infection 23.51 10.35 109 109523 20170 42491533
Hyperphosphataemia 23.22 10.35 3 109629 13001 42498702
Lymphadenectomy 23.08 10.35 15 109617 487 42511216
Perirectal abscess 23.05 10.35 26 109606 1812 42509891
Organic brain syndrome 22.82 10.35 13 109619 331 42511372
Infusion related reaction 22.80 10.35 80 109552 60726 42450977
Rectal abscess 22.78 10.35 25 109607 1690 42510013
Premature baby 22.54 10.35 16 109616 23137 42488566
Angina pectoris 22.50 10.35 31 109601 32865 42478838
Pelvi-ureteric obstruction 22.32 10.35 6 109626 15 42511688
Lumbosacral plexus injury 22.32 10.35 6 109626 15 42511688
Anti-cyclic citrullinated peptide antibody positive 22.22 10.35 26 109606 1886 42509817
Acute myocardial infarction 22.16 10.35 76 109556 58089 42453614
Bradycardia 22.13 10.35 129 109503 85355 42426348
Fistula discharge 21.82 10.35 20 109612 1088 42510615
Food intolerance 21.75 10.35 24 109608 1632 42510071
Abscess intestinal 21.72 10.35 25 109607 1781 42509922
Cerebral infarction 21.70 10.35 29 109603 31140 42480563
Lung consolidation 21.69 10.35 51 109581 6626 42505077
Anxiety disorder 21.66 10.35 26 109606 1937 42509766
Auditory disorder 21.66 10.35 15 109617 542 42511161
Weight bearing difficulty 21.65 10.35 21 109611 1227 42510476
Dyspnoea exertional 21.59 10.35 62 109570 50086 42461617
Aortic aneurysm rupture 21.59 10.35 20 109612 1103 42510600
Perineal pain 21.55 10.35 19 109613 982 42510721
Chest injury 21.54 10.35 25 109607 1797 42509906
Enterocutaneous fistula 21.47 10.35 21 109611 1240 42510463
Bronchial disorder 21.44 10.35 22 109610 1376 42510327
Sleep disorder due to a general medical condition 21.44 10.35 9 109623 17444 42494259
Pruritus genital 21.37 10.35 30 109602 2609 42509094
Corneal deposits 21.30 10.35 11 109621 229 42511474
Skin wrinkling 21.18 10.35 14 109618 468 42511235
Rash erythematous 20.98 10.35 148 109484 31943 42479760
Gluten sensitivity 20.97 10.35 7 109625 44 42511659
Aortic aneurysm 20.88 10.35 55 109577 7668 42504035
Neuralgia 20.88 10.35 125 109507 25522 42486181
Metastases to liver 20.74 10.35 8 109624 16318 42495385
Actinic keratosis 20.73 10.35 43 109589 5133 42506570
Throat tightness 20.71 10.35 63 109569 9536 42502167
Dermatitis bullous 20.64 10.35 58 109574 8398 42503305
Inappropriate schedule of product administration 20.64 10.35 153 109479 95749 42415954
Increased viscosity of bronchial secretion 20.63 10.35 11 109621 245 42511458
Blood cholesterol increased 20.60 10.35 23 109609 26718 42484985
Platelet count decreased 20.41 10.35 243 109389 138338 42373365
Vitreous floaters 20.41 10.35 38 109594 4192 42507511
Hepatic encephalopathy 20.27 10.35 90 109542 16352 42495351
Hypothyroidism 20.22 10.35 32 109600 32052 42479651
Cardiogenic shock 20.22 10.35 38 109594 35602 42476101
Hypogonadism 20.20 10.35 28 109604 2406 42509297
Troponin increased 20.15 10.35 12 109620 19050 42492653
Neuropathy peripheral 20.11 10.35 371 109261 101482 42410221
Intentional self-injury 20.07 10.35 7 109625 15195 42496508
Cholestatic liver injury 20.04 10.35 35 109597 3674 42508029
Painful respiration 20.02 10.35 21 109611 1348 42510355
Hyperthyroidism 20.00 10.35 6 109626 14335 42497368
Yellow fever vaccine-associated neurotropic disease 19.86 10.35 4 109628 0 42511703
Posterior tibial tendon dysfunction 19.86 10.35 4 109628 0 42511703
Acinetobacter infection 19.79 10.35 22 109610 1509 42510194
Chest pain 19.67 10.35 247 109385 139283 42372420
Incorrect dose administered 19.66 10.35 70 109562 52904 42458799
Disseminated intravascular coagulation 19.64 10.35 120 109512 24674 42487029
Ischaemic stroke 19.57 10.35 17 109615 22216 42489487
Arteriosclerosis 19.48 10.35 11 109621 17978 42493725
Obesity 19.41 10.35 9 109623 16450 42495253
Nail bed bleeding 19.39 10.35 13 109619 445 42511258
Influenza 19.38 10.35 88 109544 62087 42449616
Prostate cancer 19.36 10.35 55 109577 44588 42467115
Intestinal intraepithelial lymphocytes increased 19.33 10.35 10 109622 209 42511494
Cardiac disorder 19.28 10.35 63 109569 48869 42462834
Product substitution issue 19.23 10.35 3 109629 11287 42500416
Pruritus allergic 19.19 10.35 12 109620 364 42511339
Cystic fibrosis 19.13 10.35 25 109607 2030 42509673
Accidental overdose 19.07 10.35 27 109605 28303 42483400
Genital pain 19.05 10.35 17 109615 893 42510810
Penile haemorrhage 19.02 10.35 18 109614 1020 42510683
Retinitis viral 19.02 10.35 9 109623 154 42511549
Peroneal nerve palsy 18.86 10.35 33 109599 3469 42508234
International normalised ratio increased 18.75 10.35 198 109434 47970 42463733
Drug-induced liver injury 18.68 10.35 165 109467 38108 42473595
Fat tissue decreased 18.68 10.35 8 109624 107 42511596
Pseudopolyp 18.57 10.35 11 109621 302 42511401
Necrotising fasciitis 18.48 10.35 38 109594 4508 42507195
Jaundice 18.40 10.35 152 109480 34437 42477266
Hyperbilirubinaemia 18.38 10.35 103 109529 20532 42491171
Gastrointestinal inflammation 18.22 10.35 38 109594 4554 42507149
Nervous system disorder 18.18 10.35 90 109542 17105 42494598
Ligament injury 18.15 10.35 11 109621 315 42511388
Nail bed inflammation 18.07 10.35 9 109623 173 42511530
Mucosal disorder 18.03 10.35 25 109607 2149 42509554
Therapy partial responder 18.00 10.35 15 109617 20006 42491697
Gynaecomastia 18.00 10.35 5 109627 12562 42499141
Eyelid oedema 17.96 10.35 43 109589 5652 42506051
Septic embolus 17.83 10.35 20 109612 1385 42510318
Haematospermia 17.73 10.35 11 109621 329 42511374
Full blood count abnormal 17.72 10.35 31 109601 29845 42481858
Loss of personal independence in daily activities 17.71 10.35 67 109565 49749 42461954
Clostridial infection 17.70 10.35 34 109598 3840 42507863
Prolapse 17.63 10.35 4 109628 3 42511700
Withdrawal syndrome 17.54 10.35 8 109624 14767 42496936
Corynebacterium infection 17.51 10.35 16 109616 867 42510836
Necrotising scleritis 17.48 10.35 7 109625 78 42511625
Tongue coated 17.44 10.35 12 109620 429 42511274
Lip erosion 17.42 10.35 14 109618 636 42511067
Orchitis 17.36 10.35 25 109607 2226 42509477
Dermatitis exfoliative generalised 17.33 10.35 43 109589 5781 42505922
Neuropsychiatric symptoms 17.32 10.35 15 109617 757 42510946
Faciobrachial dystonic seizure 17.17 10.35 7 109625 82 42511621
Multiple organ dysfunction syndrome 16.97 10.35 347 109285 96688 42415015
Interstitial lung disease 16.97 10.35 125 109507 78337 42433366
Device leakage 16.93 10.35 3 109629 10282 42501421
Jaundice cholestatic 16.93 10.35 40 109592 5213 42506490
Underdose 16.91 10.35 11 109621 16655 42495048
Thrombotic thrombocytopenic purpura 16.91 10.35 33 109599 3771 42507932
Generalised tonic-clonic seizure 16.86 10.35 121 109511 26258 42485445
Fluid retention 16.83 10.35 35 109597 31584 42480119
Visual impairment 16.67 10.35 177 109455 42936 42468767
Cryptitis 16.67 10.35 10 109622 281 42511422
Muscle injury 16.60 10.35 21 109611 1651 42510052
Product quality issue 16.58 10.35 13 109619 17869 42493834
Procedural pain 16.49 10.35 42 109590 5737 42505966
Blood pressure increased 16.47 10.35 175 109457 101753 42409950
Diabetes mellitus 16.46 10.35 89 109543 59998 42451705
Oxidative stress 16.45 10.35 7 109625 92 42511611
Impaired work ability 16.30 10.35 68 109564 12023 42499680
Blood phosphorus increased 16.14 10.35 6 109626 12519 42499184
White blood cell count decreased 16.09 10.35 194 109438 110202 42401501
Angina bullosa haemorrhagica 16.02 10.35 6 109626 55 42511648
Ejection fraction decreased 15.94 10.35 20 109612 22067 42489636
Respiratory tract infection bacterial 15.91 10.35 22 109610 1887 42509816
Gallbladder polyp 15.90 10.35 12 109620 497 42511206
Fear of death 15.84 10.35 13 109619 609 42511094
Cramp-fasciculation syndrome 15.83 10.35 4 109628 7 42511696
Fluorosis 15.83 10.35 6 109626 57 42511646
Macroglossia 15.83 10.35 12 109620 500 42511203
Measles 15.83 10.35 10 109622 309 42511394
Gastrointestinal pain 15.75 10.35 35 109597 4380 42507323
Herpes zoster meningoencephalitis 15.73 10.35 12 109620 505 42511198
Drug dependence 15.66 10.35 32 109600 29062 42482641
Microvillous inclusion disease 15.63 10.35 9 109623 234 42511469
Subdural haematoma 15.63 10.35 22 109610 23116 42488587
Hyperkalaemia 15.62 10.35 132 109500 80326 42431377
Joint stiffness 15.61 10.35 68 109564 12254 42499449
Arteriosclerosis coronary artery 15.59 10.35 15 109617 18662 42493041
Urinary tract obstruction 15.58 10.35 33 109599 3998 42507705
Idiosyncratic drug reaction 15.55 10.35 12 109620 514 42511189
Muscle tightness 15.48 10.35 40 109592 5513 42506190
Hypersensitivity vasculitis 15.47 10.35 29 109603 3215 42508488
Lymphocyte count decreased 15.47 10.35 30 109602 27779 42483924
Pneumonia pseudomonal 15.41 10.35 37 109595 4872 42506831
Vitamin K deficiency 15.35 10.35 11 109621 420 42511283
Nutritional condition abnormal 15.34 10.35 12 109620 524 42511179
Nasopharyngitis 15.34 10.35 140 109492 83856 42427847
Toxic skin eruption 15.33 10.35 73 109559 13657 42498046
Intestinal fistula 15.30 10.35 17 109615 1165 42510538
Stenotrophomonas test positive 15.30 10.35 10 109622 328 42511375
Pharyngeal erythema 15.28 10.35 14 109618 761 42510942
Small fibre neuropathy 15.23 10.35 9 109623 246 42511457
Laryngeal obstruction 15.17 10.35 4 109628 9 42511694
Peripheral artery aneurysm rupture 15.17 10.35 4 109628 9 42511694
Resuscitation 15.16 10.35 21 109611 1804 42509899
Skin burning sensation 15.10 10.35 48 109584 7439 42504264
Corneal opacity 15.08 10.35 13 109619 652 42511051
Therapeutic response decreased 15.04 10.35 47 109585 36965 42474738
Product administration error 15.00 10.35 15 109617 18328 42493375
Scoliosis 14.98 10.35 28 109604 3098 42508605
Musculoskeletal discomfort 14.96 10.35 56 109576 9420 42502283
Cardio-respiratory arrest 14.90 10.35 89 109543 58547 42453156
Neuroglycopenia 14.90 10.35 3 109629 0 42511703
Eczema vesicular 14.90 10.35 3 109629 0 42511703
Glare 14.83 10.35 7 109625 119 42511584
Leukocyturia 14.78 10.35 14 109618 794 42510909
Left ventricular hypertrophy 14.74 10.35 3 109629 9316 42502387
Klebsiella infection 14.71 10.35 63 109569 11269 42500434
Epistaxis 14.67 10.35 106 109526 66720 42444983
Bacterial disease carrier 14.66 10.35 13 109619 677 42511026
Sensory processing disorder 14.65 10.35 5 109627 34 42511669
Generalised oedema 14.63 10.35 78 109554 15258 42496445
Tendon calcification 14.59 10.35 6 109626 72 42511631
Intestinal stenosis 14.55 10.35 26 109606 2778 42508925
Salivary hypersecretion 14.51 10.35 5 109627 10938 42500765
Myosclerosis 14.51 10.35 9 109623 269 42511434
Systemic candida 14.50 10.35 38 109594 5281 42506422
Injection site haemorrhage 14.50 10.35 6 109626 11730 42499973
Scrotal pain 14.49 10.35 15 109617 948 42510755
Catatonia 14.46 10.35 42 109590 6197 42505506
Inappropriate antidiuretic hormone secretion 14.36 10.35 82 109550 16459 42495244
Headache 14.35 10.35 488 109144 238881 42272822
Oesophageal mucosa erythema 14.28 10.35 5 109627 37 42511666
Gingival recession 14.15 10.35 11 109621 476 42511227
Muscle fatigue 14.15 10.35 20 109612 1751 42509952
Device malfunction 14.14 10.35 7 109625 12320 42499383
Plantar fasciitis 14.09 10.35 27 109605 3043 42508660
Mucosal atrophy 14.09 10.35 6 109626 79 42511624
Injection site bruising 14.06 10.35 6 109626 11519 42500184
Papillitis 14.02 10.35 6 109626 80 42511623
Myocardial ischaemia 13.99 10.35 15 109617 17747 42493956
Stenotrophomonas infection 13.94 10.35 30 109602 3674 42508029
Pelvic haemorrhage 13.88 10.35 4 109628 14 42511689
Prescribed overdose 13.86 10.35 8 109624 12919 42498784
Glycosylated haemoglobin increased 13.85 10.35 8 109624 12916 42498787
Escherichia urinary tract infection 13.82 10.35 33 109599 4330 42507373
Blood test abnormal 13.82 10.35 8 109624 12898 42498805
Increased appetite 13.81 10.35 3 109629 8903 42502800
Glomerular filtration rate decreased 13.80 10.35 13 109619 16338 42495365
Hepatic cytolysis 13.76 10.35 117 109515 26727 42484976
Abscess bacterial 13.69 10.35 8 109624 214 42511489
Flushing 13.69 10.35 49 109583 36979 42474724
Glomerulonephritis acute 13.67 10.35 7 109625 143 42511560
Pneumonia 13.66 10.35 919 108713 421230 42090473
Pustule 13.64 10.35 16 109616 1163 42510540
Scleromalacia 13.63 10.35 5 109627 43 42511660
Myoglobin urine present 13.63 10.35 7 109625 144 42511559
Osteoporosis 13.61 10.35 11 109621 14895 42496808
Transient ischaemic attack 13.60 10.35 43 109589 33696 42478007
Hand deformity 13.59 10.35 30 109602 3738 42507965
No adverse event 13.54 10.35 53 109579 38968 42472735
Bronchopulmonary aspergillosis 13.52 10.35 91 109541 19338 42492365
Dermatitis exfoliative 13.52 10.35 44 109588 6903 42504800
Autonomic neuropathy 13.50 10.35 15 109617 1028 42510675
Otorrhoea 13.50 10.35 13 109619 753 42510950
Osteolysis 13.48 10.35 29 109603 3551 42508152
Myasthenia gravis 13.42 10.35 13 109619 16124 42495579
Needle issue 13.41 10.35 3 109629 8724 42502979
Magnesium deficiency 13.33 10.35 7 109625 151 42511552
Gastrooesophageal reflux disease 13.28 10.35 65 109567 44958 42466745
Roseolovirus test positive 13.27 10.35 6 109626 92 42511611
Ligament disorder 13.25 10.35 7 109625 153 42511550
Constipation 13.24 10.35 317 109315 161974 42349729
Sitting disability 13.24 10.35 8 109624 228 42511475
Acute febrile neutrophilic dermatosis 13.20 10.35 20 109612 1864 42509839
Ear pain 13.16 10.35 41 109591 6285 42505418
Probiotic therapy 13.13 10.35 7 109625 156 42511547
Cervicobrachial syndrome 13.12 10.35 9 109623 320 42511383
Muscular weakness 13.12 10.35 294 109338 83204 42428499
Chest X-ray abnormal 13.11 10.35 33 109599 4475 42507228
Groin pain 13.11 10.35 40 109592 6064 42505639
Weight increased 13.11 10.35 197 109435 107786 42403917
Injection site mass 13.07 10.35 3 109629 8572 42503131
Atelectasis 13.07 10.35 90 109542 19271 42492432
Hepatotoxicity 13.06 10.35 110 109522 25057 42486646
Urinary retention 13.06 10.35 166 109466 42048 42469655
Hyperlipidaemia 13.05 10.35 22 109610 21494 42490209
Axonal neuropathy 13.05 10.35 16 109616 1219 42510484
Hypotension 13.04 10.35 536 109096 257095 42254608
Syringe issue 13.03 10.35 3 109629 8553 42503150
Exposure during pregnancy 13.01 10.35 3 109629 8545 42503158
Blood creatine phosphokinase increased 13.01 10.35 72 109560 48266 42463437
Right ventricle outflow tract obstruction 12.97 10.35 5 109627 50 42511653
Arterial angioplasty 12.97 10.35 5 109627 50 42511653
Palpitations 12.97 10.35 193 109439 50604 42461099
Pulmonary arterial hypertension 12.92 10.35 5 109627 10182 42501521
Enterococcal bacteraemia 12.92 10.35 24 109608 2643 42509060
Thrombocytosis 12.90 10.35 34 109598 4741 42506962
Gingival pain 12.89 10.35 3 109629 8491 42503212
Defaecation urgency 12.86 10.35 29 109603 3665 42508038
Bilirubin conjugated 12.83 10.35 3 109629 3 42511700
Vertebral artery hypoplasia 12.83 10.35 3 109629 3 42511700
Systemic inflammatory response syndrome 12.79 10.35 45 109587 7345 42504358
Abdominal wall abscess 12.77 10.35 12 109620 674 42511029
Incision site discharge 12.75 10.35 4 109628 20 42511683
Faecal calprotectin increased 12.74 10.35 26 109606 3068 42508635
Mycobacterial peritonitis 12.73 10.35 7 109625 166 42511537
Face oedema 12.69 10.35 69 109563 13597 42498106
Injection site reaction 12.69 10.35 13 109619 15708 42495995
Cough 12.64 10.35 355 109277 177748 42333955
Drug intolerance 12.62 10.35 139 109493 80285 42431418
Cataract subcapsular 12.58 10.35 11 109621 562 42511141
Product dose omission in error 12.58 10.35 3 109629 8351 42503352
Large intestinal stenosis 12.58 10.35 20 109612 1943 42509760
Urge incontinence 12.55 10.35 11 109621 564 42511139
Hypofibrinogenaemia 12.55 10.35 20 109612 1947 42509756
Asphyxia 12.52 10.35 3 109629 8323 42503380
Staphylococcal infection 12.50 10.35 150 109482 37493 42474210
Meningitis 12.41 10.35 38 109594 5771 42505932
Procalcitonin decreased 12.38 10.35 8 109624 257 42511446
Nephritis 12.37 10.35 29 109603 3760 42507943
Microbiology test abnormal 12.37 10.35 3 109629 4 42511699
Kounis syndrome 12.36 10.35 27 109605 3341 42508362
Enterobacter sepsis 12.35 10.35 14 109618 981 42510722
Hypercholesterolaemia 12.35 10.35 9 109623 12840 42498863
Thrombocytopenia 12.32 10.35 603 109029 189676 42322027
Glomerulonephritis 12.31 10.35 23 109609 2543 42509160
Gastrointestinal haemorrhage 12.31 10.35 177 109455 97549 42414154
Device issue 12.30 10.35 10 109622 13499 42498204
Gallbladder fistula 12.28 10.35 4 109628 23 42511680
Apoptosis 12.26 10.35 11 109621 582 42511121
Oral candidiasis 12.23 10.35 71 109561 14334 42497369
Atrioventricular block complete 12.23 10.35 7 109625 11357 42500346
Dyslexia 12.22 10.35 9 109623 359 42511344
Cardiac murmur 12.21 10.35 9 109623 12766 42498937
Hepatic function abnormal 12.21 10.35 80 109552 51487 42460216
Dysuria 12.18 10.35 128 109504 30968 42480735
Anticoagulation drug level above therapeutic 12.16 10.35 23 109609 2567 42509136
Haemoglobin decreased 12.16 10.35 254 109378 132217 42379486
Haemorrhoids thrombosed 12.09 10.35 8 109624 268 42511435
Muscle contractions involuntary 12.05 10.35 20 109612 2014 42509689
Papilloma 12.04 10.35 9 109623 367 42511336
Eye infection fungal 12.03 10.35 10 109622 477 42511226
Eye excision 12.00 10.35 4 109628 25 42511678
Colonic fistula 11.99 10.35 10 109622 479 42511224
Wheezing 11.97 10.35 87 109545 54694 42457009
Necrosis 11.95 10.35 41 109591 6610 42505093
Pseudoporphyria 11.90 10.35 10 109622 484 42511219
Blood triglycerides increased 11.89 10.35 14 109618 15882 42495821
Mucosal hyperaemia 11.87 10.35 4 109628 26 42511677
Sensitisation 11.83 10.35 8 109624 278 42511425
Bladder pain 11.81 10.35 11 109621 611 42511092
Hepatic amoebiasis 11.80 10.35 5 109627 65 42511638
Spontaneous haematoma 11.76 10.35 12 109620 746 42510957
Cardiac arrest 11.75 10.35 204 109428 109116 42402587
Purpura 11.73 10.35 61 109571 11818 42499885
Cerebral ischaemia 11.72 10.35 42 109590 6917 42504786
Anaphylactic shock 11.72 10.35 27 109605 23490 42488213
Cardiac failure chronic 11.71 10.35 5 109627 9596 42502107
Facial wasting 11.70 10.35 6 109626 123 42511580
Neoplasm progression 11.66 10.35 37 109595 28963 42482740
Atrial septal defect 11.63 10.35 3 109629 7916 42503787
Gastrointestinal infection 11.62 10.35 41 109591 6702 42505001
Colour blindness 11.61 10.35 9 109623 388 42511315
Bone infarction 11.55 10.35 8 109624 289 42511414
Renal abscess 11.55 10.35 9 109623 391 42511312
Therapy interrupted 11.53 10.35 25 109607 22225 42489478
Breast inflammation 11.50 10.35 4 109628 29 42511674
Oliguria 11.50 10.35 51 109581 9262 42502441
Erysipelas 11.47 10.35 39 109593 6257 42505446
Intestinal ulcer 11.45 10.35 14 109618 1063 42510640
Anorectal infection 11.45 10.35 9 109623 396 42511307
Crystal nephropathy 11.41 10.35 11 109621 638 42511065
Pulmonary toxicity 11.40 10.35 4 109628 8651 42503052
Arteritis infective 11.34 10.35 5 109627 72 42511631
Dyslipidaemia 11.34 10.35 5 109627 9413 42502290
Prothrombin time shortened 11.32 10.35 17 109615 1572 42510131
Rotator cuff syndrome 11.31 10.35 40 109592 6546 42505157
Hepato-lenticular degeneration 11.30 10.35 3 109629 7 42511696
Blood catecholamines decreased 11.30 10.35 3 109629 7 42511696
Glutathione decreased 11.30 10.35 3 109629 7 42511696
Product use in unapproved indication 11.29 10.35 375 109257 184081 42327622
Septic pulmonary embolism 11.24 10.35 6 109626 134 42511569
Mycobacterium fortuitum infection 11.22 10.35 9 109623 408 42511295
Pleocytosis 11.18 10.35 11 109621 654 42511049
Perineal abscess 11.16 10.35 9 109623 411 42511292
Purpura non-thrombocytopenic 11.16 10.35 5 109627 75 42511628
Dysaesthesia 11.14 10.35 22 109610 2535 42509168
Motor dysfunction 11.13 10.35 46 109586 8100 42503603
Type 2 diabetes mellitus 11.10 10.35 19 109613 18452 42493251
Adverse event 11.10 10.35 28 109604 23612 42488091
Joint instability 11.10 10.35 10 109622 532 42511171
Muscle discomfort 11.09 10.35 7 109625 216 42511487
Osteonecrosis of jaw 11.08 10.35 20 109612 19029 42492674
Hepatic failure 11.02 10.35 148 109484 37952 42473751
Retinopathy hypertensive 11.02 10.35 8 109624 312 42511391
Herpes zoster reactivation 10.99 10.35 9 109623 420 42511283
Immunosuppression 10.97 10.35 4 109628 8449 42503254
Aspartate aminotransferase 10.96 10.35 6 109626 141 42511562
Overgrowth bacterial 10.85 10.35 6 109626 144 42511559
Human polyomavirus infection 10.83 10.35 15 109617 1288 42510415
Faecal calprotectin abnormal 10.82 10.35 8 109624 321 42511382
Capnocytophaga infection 10.81 10.35 6 109626 145 42511558
Drug level increased 10.81 10.35 109 109523 26091 42485612
Epididymitis 10.77 10.35 24 109608 3010 42508693
Rash pruritic 10.76 10.35 133 109499 33470 42478233
Gastroenteritis yersinia 10.76 10.35 3 109629 9 42511694
Subacute cutaneous lupus erythematosus 10.71 10.35 16 109616 1472 42510231
Aggression 10.71 10.35 68 109564 44095 42467608
Urinary tract infection pseudomonal 10.67 10.35 15 109617 1306 42510397
Injection site swelling 10.63 10.35 17 109615 16956 42494747
Hepatosplenic candidiasis 10.59 10.35 7 109625 234 42511469
Loss of proprioception 10.58 10.35 9 109623 443 42511260
Biopsy 10.56 10.35 8 109624 333 42511370
Foot amputation 10.54 10.35 12 109620 845 42510858
Abdominal pain lower 10.53 10.35 60 109572 12032 42499671
Multiple-drug resistance 10.52 10.35 42 109590 7280 42504423
Renal cancer 10.49 10.35 4 109628 8220 42503483
Oxygen saturation decreased 10.47 10.35 111 109521 64576 42447127
Necrotising soft tissue infection 10.45 10.35 6 109626 155 42511548
Product storage error 10.45 10.35 8 109624 11132 42500571
Neuroleptic malignant syndrome 10.42 10.35 25 109607 21447 42490256
Candida osteomyelitis 10.37 10.35 4 109628 40 42511663
Irritable bowel syndrome 10.36 10.35 31 109601 4650 42507053

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tendon pain 1214.94 9.82 471 236085 5855 110346888
Drug hypersensitivity 1165.32 9.82 2821 233735 451269 109901474
Tendonitis 1022.21 9.82 658 235898 25425 110327318
Tendon rupture 654.67 9.82 396 236160 13682 110339061
Drug reaction with eosinophilia and systemic symptoms 631.00 9.82 827 235729 81268 110271475
Tendon disorder 607.55 9.82 315 236241 8022 110344721
Pathogen resistance 562.92 9.82 392 236164 17280 110335463
Drug interaction 555.14 9.82 2328 234228 497855 109854888
Toxic epidermal necrolysis 522.98 9.82 626 235930 56101 110296642
Pemphigus 419.01 9.82 8 236548 214562 110138181
Tubulointerstitial nephritis 408.00 9.82 541 236015 53743 110299000
Clostridium difficile colitis 390.27 9.82 475 236081 43303 110309440
Duodenal ulcer perforation 349.51 9.82 6 236550 177694 110175049
Hand deformity 344.69 9.82 34 236522 218472 110134271
Acute kidney injury 344.62 9.82 2432 234124 632998 109719745
Synovitis 341.57 9.82 83 236473 274009 110078734
Glossodynia 324.23 9.82 45 236511 221959 110130784
Clostridium difficile infection 323.72 9.82 474 236082 51655 110301088
Helicobacter infection 322.28 9.82 16 236540 181861 110170882
Pericarditis 313.98 9.82 47 236509 219067 110133676
Nasal oedema 301.64 9.82 186 236370 6653 110346090
Drug resistance 284.79 9.82 466 236090 55908 110296835
Systemic lupus erythematosus 280.21 9.82 97 236459 254241 110098502
Stevens-Johnson syndrome 276.21 9.82 416 236140 46485 110306258
Anti-cyclic citrullinated peptide antibody positive 275.11 9.82 33 236523 181951 110170792
Maternal exposure during pregnancy 259.53 9.82 110 236446 254773 110097970
Rheumatoid factor positive 256.59 9.82 5 236551 131635 110221108
Tendon discomfort 255.90 9.82 81 236475 520 110352223
Rheumatic fever 245.93 9.82 3 236553 122576 110230167
Myalgia 245.18 9.82 1034 235522 221347 110131396
Type 2 diabetes mellitus 238.44 9.82 45 236511 177187 110175556
Rheumatoid arthritis 236.60 9.82 177 236379 299436 110053307
Psoriatic arthropathy 225.57 9.82 70 236486 196691 110156052
Rash maculo-papular 222.35 9.82 491 236065 73731 110279012
Folliculitis 220.42 9.82 45 236511 167608 110185135
Wound 220.40 9.82 113 236443 234324 110118419
Muscle injury 209.23 9.82 27 236529 140780 110211963
Completed suicide 206.20 9.82 132 236424 242249 110110494
Total lung capacity increased 197.85 9.82 128 236428 4984 110347759
Death 195.77 9.82 800 235756 698069 109654674
Fistula 187.62 9.82 196 236360 15103 110337640
Infusion related reaction 185.53 9.82 332 236224 380830 109971913
Lip dry 183.23 9.82 7 236549 100076 110252667
Facet joint syndrome 176.49 9.82 7 236549 96821 110255922
Tinnitus 169.61 9.82 390 236166 60150 110292593
Colitis 167.66 9.82 541 236015 101782 110250961
Impaired healing 167.48 9.82 107 236449 196610 110156133
Arthropathy 167.14 9.82 222 236334 287300 110065443
Dysbiosis 162.39 9.82 83 236473 2049 110350694
Blood cholesterol increased 162.18 9.82 97 236459 184688 110168055
Asthma-chronic obstructive pulmonary disease overlap syndrome 159.53 9.82 122 236434 6222 110346521
Discomfort 159.20 9.82 135 236421 214572 110138171
Alopecia 159.05 9.82 339 236217 364414 109988329
Oedema 157.38 9.82 874 235682 209102 110143641
Eosinophilia 155.49 9.82 367 236189 57569 110295174
Torsade de pointes 149.79 9.82 212 236344 22388 110330355
Nasopharyngitis 146.26 9.82 399 236157 393962 109958781
Stomatitis 145.80 9.82 220 236336 270022 110082721
Pseudomembranous colitis 145.74 9.82 116 236440 6275 110346468
Anal fistula 144.29 9.82 130 236426 8343 110344400
Ill-defined disorder 142.40 9.82 79 236477 156774 110195969
Intentional overdose 140.01 9.82 54 236502 132447 110220296
Contraindicated product administered 139.93 9.82 196 236360 248071 110104672
Fall 138.65 9.82 742 235814 602740 109750003
Joint range of motion decreased 136.67 9.82 45 236511 121787 110230956
Bursitis 135.54 9.82 54 236502 129864 110222879
Respiratory tract infection 135.31 9.82 398 236158 71219 110281524
Burning sensation 134.96 9.82 389 236167 68823 110283920
Peripheral venous disease 130.24 9.82 14 236542 84103 110268640
Pseudomonas infection 128.33 9.82 221 236335 27632 110325111
Irritable bowel syndrome 127.02 9.82 99 236457 164116 110188627
Prescribed overdose 124.92 9.82 19 236537 87562 110265181
Joint swelling 124.40 9.82 506 236050 442339 109910404
Septic shock 124.27 9.82 665 235891 156863 110195880
Hypercholesterolaemia 122.29 9.82 23 236533 90814 110261929
Nasal polyps 122.15 9.82 146 236410 13054 110339689
Panic attack 120.93 9.82 220 236336 28720 110324023
Live birth 120.28 9.82 7 236549 69477 110283266
Clostridium test positive 120.26 9.82 132 236424 10761 110341982
Anal fissure 120.11 9.82 126 236430 9755 110342988
Mobility decreased 119.83 9.82 202 236354 237220 110115523
Exposure during pregnancy 119.60 9.82 109 236447 167315 110185428
Henoch-Schonlein purpura 118.51 9.82 82 236474 3575 110349168
Peripheral swelling 115.77 9.82 458 236098 403576 109949167
Swelling 115.12 9.82 376 236180 350665 110002078
Sciatica 113.05 9.82 29 236527 92370 110260373
Sinusitis 111.60 9.82 298 236258 296390 110056353
Tendon injury 111.56 9.82 68 236488 2381 110350362
Drug abuse 110.35 9.82 130 236426 177281 110175462
Swelling face 110.11 9.82 440 236116 91881 110260862
C-reactive protein abnormal 108.39 9.82 72 236484 129623 110223120
Acute generalised exanthematous pustulosis 106.58 9.82 177 236379 21487 110331256
Weight increased 105.98 9.82 499 236057 419145 109933598
Renal tubular necrosis 105.62 9.82 214 236342 30261 110322482
Joint noise 103.92 9.82 87 236469 5056 110347687
Injection site pain 103.73 9.82 137 236419 177785 110174958
Multiple organ dysfunction syndrome 103.50 9.82 616 235940 151094 110201649
Road traffic accident 102.04 9.82 51 236505 107347 110245396
Sarcoidosis 101.70 9.82 130 236426 12449 110340294
Choroiditis 100.68 9.82 55 236501 1560 110351183
Loss of employment 99.12 9.82 71 236485 3273 110349470
Geotrichum infection 97.62 9.82 49 236507 1163 110351580
Hepatic enzyme increased 96.25 9.82 357 236199 320535 110032208
Abdominal pain 95.66 9.82 1585 234971 511404 109841339
Pulmonary pain 94.47 9.82 90 236466 6203 110346540
Febrile neutropenia 94.04 9.82 1064 235492 315703 110037040
Crystal nephropathy 93.55 9.82 55 236501 1801 110350942
Hyperacusis 92.87 9.82 65 236491 2887 110349856
Adverse event 92.84 9.82 59 236497 108750 110243993
Treatment failure 92.22 9.82 295 236261 276939 110075804
Fibromyalgia 91.31 9.82 140 236416 170769 110181974
Muscle atrophy 90.32 9.82 126 236430 13128 110339615
Photosensitivity reaction 90.24 9.82 181 236375 25408 110327335
Injection site reaction 89.71 9.82 39 236517 89031 110263712
Candida infection 88.96 9.82 265 236291 47744 110304999
Lower limb fracture 87.78 9.82 26 236530 75322 110277421
Swollen tongue 87.22 9.82 306 236250 60056 110292687
Vomiting 87.11 9.82 2556 234000 908119 109444624
Osteoarthritis 86.16 9.82 162 236394 182461 110170282
Grip strength decreased 85.82 9.82 32 236524 80142 110272601
Rhinitis allergic 84.93 9.82 144 236412 17778 110334965
Anxiety 84.60 9.82 1118 235438 343960 110008783
Wheezing 84.39 9.82 876 235680 254354 110098389
Anal abscess 84.37 9.82 114 236442 11524 110341219
Female genital tract fistula 84.01 9.82 137 236419 16382 110336361
Jaundice cholestatic 83.76 9.82 128 236428 14480 110338263
Paraesthesia oral 83.60 9.82 207 236349 33464 110319279
Pyrexia 83.14 9.82 2511 234045 895754 109456989
Therapeutic product effect decreased 82.64 9.82 258 236298 244058 110108685
Abscess 82.56 9.82 182 236374 27287 110325456
Nephritis allergic 82.17 9.82 42 236514 1037 110351706
Connective tissue disorder 81.74 9.82 50 236506 1762 110350981
Psoriasis 81.39 9.82 108 236448 139885 110212858
Wound infection 80.00 9.82 54 236502 96411 110256332
Sleep disorder due to a general medical condition 79.84 9.82 9 236547 52103 110300640
Dermatitis exfoliative 79.01 9.82 109 236447 11238 110341505
Product quality issue 77.61 9.82 34 236522 77265 110275478
Autoimmune disorder 77.38 9.82 22 236534 65461 110287282
Muscle rupture 77.07 9.82 69 236487 4391 110348352
Leukocytosis 77.02 9.82 272 236284 53556 110299187
Early retirement 75.92 9.82 16 236540 8 110352735
Hepatitis cholestatic 75.25 9.82 135 236421 17431 110335312
Onychomadesis 74.95 9.82 6 236550 45657 110307086
Adjustment disorder with depressed mood 74.22 9.82 5 236551 43878 110308865
Cutaneous vasculitis 73.64 9.82 112 236444 12617 110340126
Dysplastic naevus 73.39 9.82 36 236520 812 110351931
Lung disorder 72.98 9.82 174 236382 179873 110172870
Aspergillus infection 72.82 9.82 166 236390 25450 110327293
Dry mouth 72.78 9.82 204 236352 199744 110152999
Staphylococcal infection 71.44 9.82 318 236238 69626 110283117
Hypomania 70.97 9.82 98 236458 10112 110342631
Hypertension 70.85 9.82 723 235833 509361 109843382
Suicide attempt 70.68 9.82 70 236486 103324 110249419
Factor V inhibition 70.46 9.82 28 236528 373 110352370
Abdominal discomfort 70.35 9.82 523 236033 393335 109959408
Prescribed underdose 69.78 9.82 26 236530 65148 110287595
Incorrect route of product administration 69.52 9.82 25 236531 64036 110288707
Muscle twitching 69.07 9.82 179 236377 29756 110322987
Rash morbilliform 68.78 9.82 85 236471 7866 110344877
Proctitis 68.60 9.82 127 236429 16800 110335943
Chronic sinusitis 68.49 9.82 160 236396 24924 110327819
Photodermatosis 67.58 9.82 37 236519 1054 110351689
Pulmonary fibrosis 67.58 9.82 71 236485 101971 110250772
Lower respiratory tract infection 67.42 9.82 279 236277 242827 110109916
Megacolon 67.36 9.82 63 236493 4242 110348501
Amyloid arthropathy 67.33 9.82 43 236513 1637 110351106
Neuropathy peripheral 66.86 9.82 631 235925 178646 110174097
Food intolerance 66.55 9.82 64 236492 4463 110348280
Vaginal flatulence 66.26 9.82 104 236452 12040 110340703
Erythema 65.99 9.82 931 235625 290516 110062227
Dysphonia 65.72 9.82 329 236227 75600 110277143
Abdominal pain lower 65.51 9.82 202 236354 37081 110315662
Liver injury 64.49 9.82 141 236415 150272 110202471
Trimethylaminuria 63.55 9.82 22 236534 193 110352550
Product dose omission issue 62.99 9.82 416 236140 321366 110031377
Pregnancy 62.52 9.82 16 236540 51051 110301692
Eye pain 62.33 9.82 242 236314 49857 110302886
Nail disorder 62.21 9.82 23 236533 57912 110294831
Blepharospasm 61.96 9.82 20 236536 54831 110297912
Hip arthroplasty 61.91 9.82 21 236535 55792 110296951
Osteoporosis 60.74 9.82 58 236498 87094 110265649
Onychomycosis 60.71 9.82 6 236550 38525 110314218
Drug ineffective for unapproved indication 60.43 9.82 402 236154 102436 110250307
Contusion 60.33 9.82 275 236281 233086 110119657
Toxic encephalopathy 60.22 9.82 113 236443 15101 110337642
Retinitis viral 60.17 9.82 26 236530 433 110352310
Infective pulmonary exacerbation of cystic fibrosis 60.08 9.82 111 236445 14660 110338083
Malignant neoplasm progression 59.97 9.82 183 236373 174384 110178359
Sepsis 58.94 9.82 1006 235550 326340 110026403
Linear IgA disease 58.84 9.82 59 236497 4330 110348413
Solar lentigo 58.59 9.82 38 236518 1486 110351257
Urinary tract infection 58.12 9.82 1001 235555 325281 110027462
Drug intolerance 57.74 9.82 573 235983 405939 109946804
Therapeutic response decreased 57.58 9.82 73 236483 96426 110256317
Injection site erythema 57.49 9.82 70 236486 94106 110258637
Asthma 57.24 9.82 801 235755 249490 110103253
Electrocardiogram QT prolonged 56.99 9.82 414 236142 108546 110244197
Cholecystitis chronic 56.97 9.82 85 236471 9415 110343328
Impaired work ability 56.92 9.82 154 236402 26265 110326478
Accidental exposure to product 56.91 9.82 18 236538 49990 110302753
Weight bearing difficulty 56.31 9.82 53 236503 3598 110349145
Fistula discharge 55.92 9.82 38 236518 1608 110351135
Symmetrical drug-related intertriginous and flexural exanthema 55.59 9.82 40 236516 1857 110350886
Oral candidiasis 55.51 9.82 216 236340 44544 110308199
Spinal muscular atrophy 55.36 9.82 24 236532 403 110352340
Fixed eruption 55.11 9.82 56 236500 4176 110348567
Skin candida 54.68 9.82 43 236513 2285 110350458
Enterococcal infection 54.62 9.82 129 236427 20237 110332506
Cholelithiasis 54.31 9.82 274 236282 63148 110289595
General physical health deterioration 54.13 9.82 615 235941 424680 109928063
Toxic skin eruption 53.97 9.82 155 236401 27360 110325383
COVID-19 53.58 9.82 306 236250 244754 110107989
Toxicity to various agents 53.22 9.82 716 235840 479839 109872904
Liver function test increased 52.81 9.82 67 236489 88481 110264262
Bronchiectasis 52.72 9.82 185 236371 36308 110316435
Coma 52.61 9.82 108 236448 117761 110234982
Foot deformity 52.47 9.82 19 236537 48461 110304282
Hyperfibrinolysis 52.39 9.82 13 236543 27 110352716
Segmental diverticular colitis 52.19 9.82 18 236538 156 110352587
Nervous system disorder 52.19 9.82 168 236388 31553 110321190
Cerebrovascular accident 52.18 9.82 205 236351 181079 110171664
Tracheobronchomegaly 52.10 9.82 12 236544 15 110352728
Paraesthesia 51.67 9.82 855 235701 275666 110077077
Radiculopathy 51.34 9.82 122 236434 19214 110333529
Cholestasis 51.28 9.82 273 236283 64245 110288498
Myelosuppression 50.64 9.82 77 236479 94263 110258480
Escherichia infection 50.48 9.82 138 236418 23678 110329065
Coeliac disease 50.12 9.82 15 236541 43172 110309571
Diverticulitis 49.96 9.82 237 236319 53285 110299458
Blister 49.67 9.82 284 236272 227092 110125651
Thrombocytopenia 49.63 9.82 1034 235522 347851 110004892
Cardiac murmur 49.53 9.82 140 236416 24488 110328255
Hallucination 49.43 9.82 379 236177 101053 110251690
Myoclonus 49.16 9.82 169 236387 32829 110319914
Loss of personal independence in daily activities 48.91 9.82 161 236395 149859 110202884
Diarrhoea 48.36 9.82 2936 233620 1136569 109216174
Vaginal discharge 47.56 9.82 113 236443 17795 110334948
Neutropenia 47.48 9.82 1092 235464 373528 109979215
Cross sensitivity reaction 47.33 9.82 59 236497 5508 110347235
Infective aneurysm 47.28 9.82 33 236523 1459 110351284
Rectal abscess 47.16 9.82 42 236514 2654 110350089
Therapeutic product effect incomplete 47.04 9.82 283 236273 223522 110129221
Dermatitis bullous 46.98 9.82 111 236445 17418 110335325
Pouchitis 46.86 9.82 32 236524 1365 110351378
Cystic fibrosis 46.55 9.82 54 236502 4677 110348066
Vulvovaginal burning sensation 46.00 9.82 37 236519 2032 110350711
Pedal pulse abnormal 45.97 9.82 18 236538 230 110352513
Dysuria 45.93 9.82 252 236304 59979 110292764
Underdose 45.82 9.82 41 236515 63513 110289230
Device expulsion 45.69 9.82 6 236550 30885 110321858
Disturbance in attention 45.03 9.82 256 236300 61739 110291004
Musculoskeletal injury 44.83 9.82 17 236539 198 110352545
Pancytopenia 44.80 9.82 663 235893 208950 110143793
Angioedema 44.67 9.82 362 236194 98138 110254605
Sputum increased 44.25 9.82 58 236498 5693 110347050
Trichoglossia 44.15 9.82 26 236530 854 110351889
Lupus-like syndrome 44.13 9.82 16 236540 40776 110311967
Pneumonia 43.97 9.82 2294 234262 874420 109478323
Sphingomonas paucimobilis infection 43.80 9.82 15 236541 127 110352616
Exostosis 43.38 9.82 22 236534 45934 110306809
Motor neurone disease 43.33 9.82 24 236532 700 110352043
Oesophageal spasm 43.23 9.82 46 236510 3620 110349123
Agranulocytosis 42.24 9.82 251 236305 61509 110291234
Emotional distress 42.16 9.82 199 236357 44648 110308095
Persistent genital arousal disorder 42.08 9.82 23 236533 653 110352090
Ligament pain 42.08 9.82 17 236539 237 110352506
Intentional product use issue 41.97 9.82 334 236222 247572 110105171
Corynebacterium bacteraemia 41.92 9.82 16 236540 190 110352553
Skin injury 41.80 9.82 47 236509 3935 110348808
Musculoskeletal stiffness 41.58 9.82 390 236166 279432 110073311
Hepatic encephalopathy 41.47 9.82 144 236412 28112 110324631
Vitreous floaters 41.45 9.82 72 236484 9062 110343681
Vanishing bile duct syndrome 41.40 9.82 42 236514 3126 110349617
Abnormal palmar/plantar creases 41.20 9.82 8 236548 0 110352743
Prostatitis 41.01 9.82 51 236505 4750 110347993
Injection site swelling 40.90 9.82 43 236513 61747 110290996
Pyelonephritis 40.88 9.82 133 236423 25117 110327626
Lung consolidation 40.46 9.82 77 236479 10399 110342344
Fungaemia 40.19 9.82 57 236499 6029 110346714
Product use issue 39.92 9.82 450 236106 311245 110041498
Stoma closure 39.84 9.82 19 236537 402 110352341
Oliguria 39.44 9.82 108 236448 18549 110334194
Abdominal abscess 39.35 9.82 69 236487 8750 110343993
Finger deformity 39.31 9.82 11 236545 33081 110319662
Muscle contractions involuntary 39.24 9.82 48 236508 4396 110348347
Bacterial colitis 38.97 9.82 16 236540 233 110352510
Fat tissue decreased 38.86 9.82 15 236541 184 110352559
Blood bilirubin increased 38.77 9.82 287 236269 75685 110277058
Lung neoplasm malignant 38.51 9.82 159 236397 33683 110319060
Aortic aneurysm 38.50 9.82 73 236483 9831 110342912
Intraocular pressure increased 38.43 9.82 77 236479 10799 110341944
Bladder hypertrophy 38.31 9.82 26 236530 1098 110351645
Injection site bruising 38.26 9.82 32 236524 51231 110301512
Mucosal inflammation 37.64 9.82 342 236214 95799 110256944
Protothecosis 37.60 9.82 20 236536 537 110352206
Radiation inflammation 37.53 9.82 25 236531 1023 110351720
Overdose 37.29 9.82 320 236236 233474 110119269
Cholestatic liver injury 37.27 9.82 61 236495 7315 110345428
Generalised tonic-clonic seizure 37.25 9.82 222 236334 54458 110298285
Trichosporon infection 37.16 9.82 27 236529 1273 110351470
Increased bronchial secretion 37.08 9.82 44 236512 3904 110348839
Chronic fatigue syndrome 37.07 9.82 28 236528 1401 110351342
Penis injury 37.07 9.82 13 236543 119 110352624
Plantar fasciitis 37.03 9.82 50 236506 5051 110347692
Device related infection 36.89 9.82 175 236381 39344 110313399
Macular degeneration 36.81 9.82 116 236440 21543 110331200
Lower respiratory tract infection bacterial 36.75 9.82 25 236531 1060 110351683
Klebsiella infection 36.64 9.82 110 236446 19899 110332844
Abscess intestinal 36.41 9.82 40 236516 3264 110349479
Cystitis 36.32 9.82 254 236302 65782 110286961
Eyelid oedema 35.97 9.82 92 236464 15170 110337573
Drug level increased 35.95 9.82 199 236357 47520 110305223
Intentional product misuse 35.92 9.82 154 236402 132750 110219993
Neuralgia 35.75 9.82 201 236355 48277 110304466
Wrong technique in product usage process 35.71 9.82 84 236472 87264 110265479
Visual acuity reduced 35.71 9.82 150 236406 32023 110320720
International normalised ratio increased 35.68 9.82 312 236244 86460 110266283
Large intestine infection 35.65 9.82 46 236510 4446 110348297
Rhabdomyolysis 35.48 9.82 404 236152 119997 110232746
Hepatic cytolysis 35.28 9.82 220 236336 54833 110297910
Acute hepatic failure 35.15 9.82 163 236393 36305 110316438
Perineal pain 35.14 9.82 28 236528 1517 110351226
Hepatotoxicity 34.95 9.82 244 236312 63156 110289587
Memory impairment 34.42 9.82 263 236293 196681 110156062
Haematuria 34.42 9.82 299 236257 82706 110270037
Depersonalisation/derealisation disorder 34.29 9.82 32 236524 2149 110350594
Calcium ionised decreased 34.26 9.82 20 236536 646 110352097
Aortic valve prolapse 33.89 9.82 8 236548 12 110352731
Dysaesthesia 33.76 9.82 56 236500 6791 110345952
Yellow fever 33.56 9.82 7 236549 3 110352740
Gut fermentation syndrome 33.45 9.82 9 236547 29 110352714
Sleep disorder 33.44 9.82 268 236288 198376 110154367
Dermatitis exfoliative generalised 33.31 9.82 73 236483 10899 110341844
Lymphoedema 33.14 9.82 88 236468 14841 110337902
Liver disorder 33.06 9.82 174 236382 142069 110210674
Factor V deficiency 33.00 9.82 11 236545 85 110352658
Prostatic pain 32.97 9.82 15 236541 284 110352459
Product substitution issue 32.89 9.82 5 236551 23056 110329687
Gastrointestinal disorder 32.69 9.82 345 236211 241607 110111136
Jaundice 32.67 9.82 228 236328 59008 110293735
Escherichia urinary tract infection 32.63 9.82 92 236464 16070 110336673
Oesophageal pain 32.38 9.82 47 236509 5078 110347665
Acute febrile neutrophilic dermatosis 32.26 9.82 46 236510 4890 110347853
Acinetobacter infection 32.21 9.82 39 236517 3534 110349209
Thrombotic thrombocytopenic purpura 32.20 9.82 56 236500 7055 110345688
Procedural anxiety 31.95 9.82 21 236535 840 110351903
Schizophrenia 31.83 9.82 111 236445 21715 110331028
Face oedema 31.82 9.82 149 236407 33320 110319423
Hospitalisation 31.63 9.82 177 236379 142316 110210427
Phlebitis 31.63 9.82 67 236489 9774 110342969
Diastasis recti abdominis 31.62 9.82 10 236546 64 110352679
Gait inability 31.60 9.82 167 236389 136209 110216534
Flank pain 31.48 9.82 115 236441 23015 110329728
Palpitations 31.48 9.82 497 236059 158715 110194028
Corneal opacity 31.33 9.82 24 236532 1227 110351516
Hallucinations, mixed 31.26 9.82 62 236494 8631 110344112
Adverse drug reaction 31.25 9.82 118 236438 105441 110247302
Undersensing 31.21 9.82 7 236549 7 110352736
Haematospermia 31.16 9.82 14 236542 257 110352486
Amnesia 31.09 9.82 118 236438 105290 110247453
Gastrointestinal inflammation 31.05 9.82 65 236491 9404 110343339
Sensory processing disorder 30.65 9.82 9 236547 43 110352700
Arthritis 30.62 9.82 221 236335 167365 110185378
Nosocomial infection 30.62 9.82 36 236520 3163 110349580
Hepatic steatosis 30.58 9.82 194 236362 48637 110304106
Muscle tightness 29.77 9.82 84 236472 14678 110338065
Throat tightness 29.60 9.82 146 236410 33343 110319400
Non-consummation 29.53 9.82 9 236547 50 110352693
Psoas abscess 29.51 9.82 25 236531 1477 110351266
Product dose omission in error 29.49 9.82 7 236549 23505 110329238
Anorectal ulcer 29.38 9.82 9 236547 51 110352692
Bladder pain 29.26 9.82 33 236523 2772 110349971
Systemic inflammatory response syndrome 29.08 9.82 77 236479 12966 110339777
Sedation complication 29.02 9.82 4 236552 19851 110332892
Idiosyncratic drug reaction 29.02 9.82 25 236531 1511 110351232
Infection 28.99 9.82 573 235983 361627 109991116
Genital pain 28.95 9.82 24 236532 1376 110351367
Aortic aneurysm rupture 28.95 9.82 24 236532 1376 110351367
Sinobronchitis 28.90 9.82 16 236540 466 110352277
Myocardial infarction 28.83 9.82 267 236289 191816 110160927
Inappropriate antidiuretic hormone secretion 28.81 9.82 146 236410 33705 110319038
Systemic candida 28.75 9.82 65 236491 9909 110342834
Immune reconstitution inflammatory syndrome 28.59 9.82 88 236468 16138 110336605
Haematochezia 28.55 9.82 375 236181 115149 110237594
Ear canal erythema 28.54 9.82 9 236547 57 110352686
Cardio-respiratory arrest 28.45 9.82 139 236417 115697 110237046
Skin burning sensation 28.44 9.82 107 236449 21718 110331025
Long QT syndrome 28.34 9.82 53 236503 7065 110345678
Myosclerosis 28.20 9.82 13 236543 254 110352489
Hypersensitivity vasculitis 28.05 9.82 52 236504 6885 110345858
Laryngitis 27.53 9.82 30 236526 42381 110310362
Therapy non-responder 27.52 9.82 210 236346 157097 110195646
Sensory disturbance 27.49 9.82 91 236465 17338 110335405
Ectropion 27.49 9.82 16 236540 514 110352229
Urosepsis 27.31 9.82 134 236422 30541 110322202
Obesity 27.28 9.82 137 236419 113214 110239529
Procedural pain 27.25 9.82 149 236407 35416 110317327
Polyneuropathy 27.19 9.82 138 236418 31874 110320869
Intentional self-injury 27.16 9.82 24 236532 37405 110315338
Necrosis 27.14 9.82 69 236487 11337 110341406
Documented hypersensitivity to administered product 26.75 9.82 21 236535 1113 110351630
Hyperbilirubinaemia 26.60 9.82 133 236423 30538 110322205
Malaise 26.54 9.82 1721 234835 670098 109682645
Normal newborn 26.54 9.82 7 236549 21889 110330854
Fungal infection 26.53 9.82 193 236363 50613 110302130
Thermal burn 26.39 9.82 55 236501 7933 110344810
Renal injury 26.28 9.82 94 236462 18619 110334124
Mitochondrial cytopathy 26.15 9.82 14 236542 381 110352362
Device malfunction 26.04 9.82 11 236545 25547 110327196
Nutritional supplementation 26.02 9.82 8 236548 46 110352697
Leukopenia 25.93 9.82 455 236101 148336 110204407
Corneal deposits 25.75 9.82 16 236540 580 110352163
Yellow fever vaccine-associated viscerotropic disease 25.75 9.82 5 236551 0 110352743
Nerve injury 25.69 9.82 65 236491 10648 110342095
Fatigue 25.68 9.82 2246 234310 1213712 109139031
COVID-19 pneumonia 25.55 9.82 25 236531 37118 110315625
Moraxella test positive 25.46 9.82 7 236549 25 110352718
Labelled drug-drug interaction medication error 25.37 9.82 127 236429 29175 110323568
Gluten sensitivity 25.33 9.82 15 236541 498 110352245
Pancreatic enzyme abnormality 25.20 9.82 11 236545 188 110352555
Back injury 25.14 9.82 39 236517 47360 110305383
Hyphaema 25.04 9.82 20 236536 1087 110351656
Transient ischaemic attack 25.00 9.82 63 236493 63919 110288824
Arrhythmia 24.99 9.82 243 236313 69332 110283411
Off label use 24.91 9.82 2820 233736 1497365 108855378
Transmission of an infectious agent via product 24.88 9.82 11 236545 194 110352549
Aeromonas infection 24.69 9.82 15 236541 522 110352221
Pudendal canal syndrome 24.67 9.82 6 236550 11 110352732
Mouth ulceration 24.65 9.82 182 236374 47956 110304787
Idiopathic intracranial hypertension 24.62 9.82 36 236520 3916 110348827
Papilloma 24.59 9.82 15 236541 526 110352217
Mineral deficiency 24.53 9.82 9 236547 95 110352648
Musculoskeletal pain 24.30 9.82 262 236294 182761 110169982
Therapy partial responder 24.30 9.82 26 236530 37035 110315708
Necrotising retinitis 24.29 9.82 23 236533 1573 110351170
Troponin increased 24.23 9.82 17 236539 29749 110322994
Panic reaction 24.22 9.82 42 236514 5280 110347463
Diaphragmatic rupture 24.00 9.82 11 236545 212 110352531
Papillitis 23.97 9.82 10 236546 152 110352591
Clostridial infection 23.94 9.82 46 236510 6256 110346487
Leukocyturia 23.89 9.82 27 236529 2273 110350470
Axonal neuropathy 23.72 9.82 27 236529 2291 110350452
Injection site pruritus 23.70 9.82 46 236510 51212 110301531
Disease progression 23.69 9.82 373 236183 243661 110109082
Depressed level of consciousness 23.57 9.82 142 236414 112136 110240607
Pulmonary arterial hypertension 23.49 9.82 21 236535 32547 110320196
Lymphocyte count decreased 23.44 9.82 55 236501 57188 110295555
Lumbosacral plexus injury 23.41 9.82 6 236550 15 110352728
Corynebacterium infection 23.41 9.82 25 236531 1975 110350768
Single functional kidney 23.41 9.82 12 236544 298 110352445
Infrequent bowel movements 23.39 9.82 26 236530 2149 110350594
Potentiating drug interaction 23.23 9.82 66 236490 11577 110341166
Haemorrhage urinary tract 23.20 9.82 30 236526 2906 110349837
Femur fracture 23.19 9.82 37 236519 44432 110308311
Collagen disorder 23.16 9.82 12 236544 305 110352438
Breast cancer 23.15 9.82 29 236527 38513 110314230
Gastroenteritis staphylococcal 23.09 9.82 12 236544 307 110352436
Anorectal disorder 23.07 9.82 29 236527 2730 110350013
Pneumococcal sepsis 23.03 9.82 26 236530 2186 110350557
Excessive eye blinking 23.00 9.82 24 236532 1846 110350897
Anhedonia 22.97 9.82 79 236477 15349 110337394
Lividity 22.91 9.82 15 236541 596 110352147
Diabetic ketoacidosis 22.89 9.82 34 236522 42024 110310719
Gastrointestinal infection 22.88 9.82 74 236482 13931 110338812
Red blood cell sedimentation rate increased 22.87 9.82 88 236468 78214 110274529
Pyelonephritis fungal 22.84 9.82 12 236544 314 110352429
Haemolytic anaemia 22.80 9.82 97 236459 20823 110331920
Pulmonary hypertension 22.65 9.82 53 236503 55167 110297576
Proctalgia 22.64 9.82 71 236485 13151 110339592
Chest injury 22.62 9.82 32 236524 3377 110349366
Confabulation 22.55 9.82 14 236542 507 110352236
Rash erythematous 22.51 9.82 271 236285 81561 110271182
Dehydration 22.50 9.82 769 235787 278742 110074001
Catatonia 22.49 9.82 64 236492 11236 110341507
Intestinal stenosis 22.49 9.82 38 236518 4677 110348066
Sopor 22.48 9.82 27 236529 36519 110316224
Psychotic disorder 22.44 9.82 186 236370 50751 110301992
Tendon necrosis 22.29 9.82 5 236551 5 110352738
Staphylococcal sepsis 22.27 9.82 85 236471 17369 110335374
Injection site warmth 22.19 9.82 5 236551 17400 110335343
Pulmonary eosinophilia 22.14 9.82 16 236540 748 110351995
Hypophosphataemia 22.07 9.82 23 236533 33159 110319584
Neoplasm progression 21.97 9.82 68 236488 64527 110288216
Septic embolus 21.97 9.82 26 236530 2300 110350443
Penile haemorrhage 21.82 9.82 17 236539 891 110351852
Feeding intolerance 21.82 9.82 19 236537 1165 110351578
Drug level decreased 21.78 9.82 88 236468 18460 110334283
Exercise tolerance decreased 21.78 9.82 66 236490 12001 110340742
Osteonecrosis 21.75 9.82 24 236532 33717 110319026
Hypogonadism 21.73 9.82 24 236532 1970 110350773
Bradycardia 21.72 9.82 220 236336 155297 110197446
Vulvovaginal pruritus 21.71 9.82 31 236525 3300 110349443
Influenza 21.69 9.82 244 236312 168857 110183886
Nephropathy toxic 21.65 9.82 116 236440 27362 110325381
Angina pectoris 21.60 9.82 65 236491 62230 110290513
Fear of death 21.60 9.82 22 236534 1645 110351098
Muscle spasticity 21.60 9.82 27 236529 35888 110316855
Chronic kidney disease 21.58 9.82 254 236302 76037 110276706
Pneumonia pseudomonal 21.56 9.82 49 236507 7497 110345246
Tremor 21.55 9.82 576 235980 201656 110151087
Immunodeficiency 21.52 9.82 31 236525 38807 110313936
Restlessness 21.45 9.82 199 236357 56060 110296683
Anuria 21.43 9.82 106 236450 24235 110328508
Taste disorder 21.42 9.82 70 236486 65317 110287426
Orchitis 21.31 9.82 23 236533 1839 110350904
Frequent bowel movements 21.23 9.82 240 236316 71150 110281593
Product label confusion 21.19 9.82 11 236545 22666 110330077
Respiratory tract infection bacterial 21.18 9.82 26 236530 2390 110350353
Hypotony of eye 21.15 9.82 13 236543 462 110352281
Intestinal dilatation 21.15 9.82 32 236524 3588 110349155
Drug dose omission by device 21.04 9.82 3 236553 14513 110338230
Bacteraemia 20.98 9.82 159 236397 42231 110310512
Multiple-drug resistance 20.79 9.82 69 236487 13166 110339577
Hepatitis infectious mononucleosis 20.78 9.82 10 236546 216 110352527
Bone marrow granuloma 20.73 9.82 6 236550 27 110352716
Anxiety disorder 20.66 9.82 38 236518 5002 110347741
Chronic gastrointestinal bleeding 20.64 9.82 13 236543 483 110352260
Tendon laxity 20.60 9.82 4 236552 0 110352743
Yellow fever vaccine-associated neurotropic disease 20.60 9.82 4 236552 0 110352743
Joint ankylosis 20.49 9.82 26 236530 2471 110350272
Type IV hypersensitivity reaction 20.47 9.82 42 236514 5991 110346752
Neutropenic sepsis 20.41 9.82 124 236432 30622 110322121
Rectal tube insertion 20.28 9.82 5 236551 10 110352733
Walking disability 20.24 9.82 26 236530 2502 110350241
Vascular purpura 20.17 9.82 32 236524 3739 110349004
Intestinal intraepithelial lymphocytes increased 20.09 9.82 10 236546 233 110352510
Blood glucose increased 19.95 9.82 184 236372 132312 110220431
Vaccination site reaction 19.93 9.82 10 236546 237 110352506
Procalcitonin decreased 19.90 9.82 8 236548 110 110352633
Ligament disorder 19.87 9.82 12 236544 413 110352330
Chemical burns of eye 19.77 9.82 8 236548 112 110352631
Foreign body aspiration 19.74 9.82 13 236543 522 110352221
Acute myocardial infarction 19.73 9.82 102 236454 83675 110269068
Acute psychosis 19.69 9.82 37 236519 4950 110347793
Thrombocytosis 19.68 9.82 58 236498 10386 110342357
Gastrointestinal pain 19.68 9.82 63 236493 11797 110340946
Right ventricular failure 19.62 9.82 16 236540 25938 110326805
Migraine 19.60 9.82 254 236302 171398 110181345
Cough 19.57 9.82 1190 235366 460451 109892292
Lip erosion 19.54 9.82 22 236534 1844 110350899
Biliary dyskinesia 19.54 9.82 25 236531 2396 110350347
Staphylococcal scalded skin syndrome 19.52 9.82 13 236543 532 110352211
Raoultella ornithinolytica infection 19.51 9.82 9 236547 176 110352567
Enterobiasis 19.50 9.82 7 236549 69 110352674
Genital paraesthesia 19.50 9.82 7 236549 69 110352674
Limb immobilisation 19.50 9.82 7 236549 69 110352674
Peritonitis 19.47 9.82 128 236428 32479 110320264
Herpes simplex colitis 19.46 9.82 8 236548 117 110352626
Myopathy 19.41 9.82 105 236451 24855 110327888
Somnolence 19.38 9.82 486 236070 296963 110055780
Lip swelling 19.20 9.82 179 236377 50488 110302255
Ischaemic stroke 19.10 9.82 37 236519 41226 110311517
Odynophagia 19.10 9.82 70 236486 14031 110338712
Full blood count abnormal 19.07 9.82 59 236497 55993 110296750
Tooth disorder 19.01 9.82 21 236535 29488 110323255
Haemorrhagic vasculitis 18.98 9.82 8 236548 125 110352618
Ependymoma 18.98 9.82 8 236548 125 110352618
Osteonecrosis of jaw 18.97 9.82 47 236509 47970 110304773
Knee arthroplasty 18.96 9.82 73 236483 64875 110287868
Blood creatine increased 18.93 9.82 61 236495 11460 110341283
Metastases to liver 18.88 9.82 29 236527 35357 110317386
Auditory disorder 18.83 9.82 19 236537 1405 110351338
Graft versus host disease 18.82 9.82 85 236471 18721 110334022
Injection site mass 18.82 9.82 15 236541 24598 110328145
Enterocutaneous fistula 18.77 9.82 24 236532 2299 110350444
Large intestinal stenosis 18.75 9.82 31 236525 3749 110348994
Ischaemic cerebral infarction 18.60 9.82 27 236529 2918 110349825
Neuropsychiatric symptoms 18.54 9.82 18 236538 1270 110351473
Genital ulceration 18.53 9.82 22 236534 1953 110350790
Hyperinsulinaemia 18.52 9.82 10 236546 277 110352466
Multiple sclerosis relapse 18.46 9.82 51 236505 50189 110302554
Injection site hyperaesthesia 18.42 9.82 7 236549 82 110352661
Nail bed bleeding 18.38 9.82 15 236541 841 110351902
Bilirubin conjugated 18.37 9.82 4 236552 3 110352740
Posterior tibial tendon dysfunction 18.37 9.82 4 236552 3 110352740
Hyperpathia 18.37 9.82 4 236552 3 110352740
Renal vein compression 18.37 9.82 4 236552 3 110352740
Bronchial disorder 18.33 9.82 26 236530 2750 110349993
Spinal fracture 18.32 9.82 13 236543 22620 110330123
Ulcer haemorrhage 18.23 9.82 13 236543 22558 110330185
Diabetes mellitus 18.18 9.82 131 236425 99250 110253493
Scleromalacia 18.05 9.82 7 236549 87 110352656
Ototoxicity 18.02 9.82 32 236524 4099 110348644
Rash macular 17.98 9.82 143 236413 38543 110314200
Proteus test positive 17.97 9.82 14 236542 734 110352009
Diabetic macroangiopathy 17.95 9.82 8 236548 144 110352599
Histamine intolerance 17.93 9.82 6 236550 47 110352696
Device leakage 17.86 9.82 6 236550 16042 110336701
Foetal death 17.86 9.82 6 236550 16039 110336704
Fracture 17.86 9.82 16 236540 24772 110327971
Faciobrachial dystonic seizure 17.84 9.82 7 236549 90 110352653
Urine odour abnormal 17.79 9.82 45 236511 7370 110345373
Anal paraesthesia 17.74 9.82 5 236551 20 110352723
Post infection glomerulonephritis 17.65 9.82 8 236548 150 110352593
Renal failure 17.64 9.82 621 235935 225953 110126790
Drug level below therapeutic 17.57 9.82 60 236496 11613 110341130
Dyslexia 17.50 9.82 11 236545 407 110352336
Withdrawal syndrome 17.44 9.82 25 236531 31355 110321388
Stenotrophomonas test positive 17.43 9.82 11 236545 410 110352333
Petechiae 17.40 9.82 97 236459 23220 110329523
Deafness bilateral 17.38 9.82 25 236531 2679 110350064
Poisoning 17.38 9.82 22 236534 29083 110323660
Glomerulonephritis 17.33 9.82 34 236522 4696 110348047
Cerebral infarction 17.33 9.82 55 236501 51783 110300960
Herpes zoster meningoencephalitis 17.30 9.82 16 236540 1062 110351681
Actinic keratosis 17.29 9.82 43 236513 6970 110345773
Inflammatory marker increased 17.27 9.82 69 236487 14400 110338343
Haemolytic uraemic syndrome 17.26 9.82 35 236521 4950 110347793
Gastroenteritis pseudomonas 17.20 9.82 6 236550 54 110352689
Meningitis candida 17.11 9.82 9 236547 236 110352507
Aural polyp 17.09 9.82 8 236548 162 110352581
Derealisation 16.97 9.82 22 236534 2136 110350607
Endocarditis 16.97 9.82 65 236491 13306 110339437
Anaphylactic reaction 16.96 9.82 341 236215 113959 110238784
Neurotoxicity 16.96 9.82 151 236405 42056 110310687
Tachypnoea 16.90 9.82 143 236413 39252 110313491
Bacterial endophthalmitis 16.88 9.82 10 236546 332 110352411
Bacteriuria 16.88 9.82 18 236538 1420 110351323
Disability 16.87 9.82 24 236532 30199 110322544
Renal impairment 16.85 9.82 525 236031 187920 110164823
Skin oedema 16.70 9.82 21 236535 1978 110350765
Stenotrophomonas infection 16.69 9.82 38 236518 5820 110346923
Anticoagulation drug level above therapeutic 16.62 9.82 33 236523 4597 110348146
Cramp-fasciculation syndrome 16.57 9.82 4 236552 7 110352736
Therapy interrupted 16.56 9.82 53 236503 49769 110302974
Aphthous ulcer 16.49 9.82 89 236467 21047 110331696
Blood calcium increased 16.49 9.82 9 236547 18031 110334712
Coronary artery disease 16.48 9.82 88 236468 71602 110281141
Wound complication 16.43 9.82 39 236517 6138 110346605
Faecal calprotectin increased 16.35 9.82 41 236515 6678 110346065
Organic brain syndrome 16.34 9.82 12 236544 575 110352168
Small fibre neuropathy 16.32 9.82 15 236541 988 110351755
Cardiac failure congestive 16.31 9.82 226 236330 150774 110201969
Infusion site streaking 16.29 9.82 12 236544 578 110352165
Hypoglossal nerve paresis 16.29 9.82 7 236549 115 110352628
No adverse event 16.23 9.82 92 236464 73747 110278996
Chromaturia 16.18 9.82 113 236443 29247 110323496
Renal tubular injury 16.11 9.82 26 236530 3082 110349661
Herpes zoster 16.11 9.82 151 236405 108228 110244515
Miosis 16.06 9.82 14 236542 21969 110330774
Gastrointestinal scarring 16.05 9.82 11 236545 472 110352271
Microvillous inclusion disease 16.02 9.82 9 236547 270 110352473
Epididymitis 16.02 9.82 23 236533 2461 110350282
C-reactive protein decreased 15.99 9.82 25 236531 2884 110349859
Tongue coated 15.97 9.82 20 236536 1876 110350867
Antimicrobial susceptibility test intermediate 15.94 9.82 5 236551 31 110352712
Deficiency of bile secretion 15.89 9.82 6 236550 69 110352674
Autonomic neuropathy 15.87 9.82 22 236534 2278 110350465
Intestinal fistula 15.76 9.82 19 236537 1714 110351029
Colonic fistula 15.74 9.82 13 236543 741 110352002
Disease complication 15.72 9.82 37 236519 5790 110346953
Renal abscess 15.71 9.82 18 236538 1538 110351205
Necrotising scleritis 15.66 9.82 9 236547 282 110352461
Intrauterine infection 15.66 9.82 6 236550 72 110352671
Groin pain 15.64 9.82 70 236486 15358 110337385
Encephalopathy 15.63 9.82 252 236304 80803 110271940
Blood test abnormal 15.62 9.82 23 236533 28531 110324212
Cryptitis 15.60 9.82 10 236546 383 110352360
Prothrombin time shortened 15.59 9.82 28 236528 3618 110349125
Drug tolerance 15.56 9.82 8 236548 16577 110336166
Head injury 15.56 9.82 44 236512 42973 110309770
Mucosal hyperaemia 15.51 9.82 6 236550 74 110352669
Chills 15.50 9.82 525 236031 190055 110162688
Purple glove syndrome 15.49 9.82 9 236547 288 110352455
Pseudomonas test positive 15.48 9.82 22 236534 2332 110350411
Hypotension 15.46 9.82 940 235616 522909 109829834
Eczema vesicular 15.45 9.82 3 236553 0 110352743
Injection site joint erythema 15.45 9.82 3 236553 0 110352743
Uveitis 15.34 9.82 89 236467 21621 110331122
Kounis syndrome 15.32 9.82 37 236519 5888 110346855
Feeling of body temperature change 15.31 9.82 38 236518 6150 110346593
Disturbance in sexual arousal 15.31 9.82 10 236546 396 110352347
Factor XIII Inhibition 15.30 9.82 5 236551 36 110352707
Hypoacusis 15.23 9.82 128 236428 35063 110317680
Product contamination microbial 15.21 9.82 15 236541 1079 110351664
Injection site urticaria 15.15 9.82 9 236547 17206 110335537
Pleural neoplasm 15.13 9.82 10 236546 404 110352339
Complex regional pain syndrome 15.11 9.82 22 236534 2383 110350360
Flushing 15.11 9.82 147 236409 104589 110248154
Substance abuse 15.07 9.82 4 236552 12459 110340284
Plantar fascial fibromatosis 15.07 9.82 5 236551 38 110352705
Fluid retention 15.06 9.82 129 236427 94178 110258565
Skin test positive 15.03 9.82 17 236539 1432 110351311
Periorbital oedema 15.01 9.82 52 236504 10140 110342603
Arterial occlusive disease 14.95 9.82 7 236549 15301 110337442
Fasciitis 14.92 9.82 14 236542 947 110351796
Autonomic nervous system imbalance 14.84 9.82 36 236520 5744 110346999
Peripheral artery aneurysm rupture 14.84 9.82 4 236552 13 110352730
Hydronephrosis 14.78 9.82 85 236471 20580 110332163
Blood pressure increased 14.78 9.82 430 236126 257943 110094800
Suspected suicide 14.76 9.82 7 236549 15192 110337551
Upper respiratory tract infection 14.75 9.82 195 236361 131133 110221610
Rectal tenesmus 14.67 9.82 21 236535 2241 110350502
Accidental overdose 14.66 9.82 59 236497 51775 110300968
Dizziness 14.62 9.82 1290 235266 696903 109655840
Scrotal oedema 14.59 9.82 18 236538 1663 110351080
Bone cyst 14.56 9.82 27 236529 3576 110349167
Exfoliative rash 14.54 9.82 31 236525 4543 110348200
Postural orthostatic tachycardia syndrome 14.51 9.82 19 236537 1863 110350880
Anal skin tags 14.50 9.82 11 236545 554 110352189
Exposure via skin contact 14.49 9.82 5 236551 13142 110339601
Metastases to lymph nodes 14.48 9.82 7 236549 15025 110337718
Basal cell carcinoma 14.46 9.82 49 236507 45221 110307522
Bladder trabeculation 14.45 9.82 6 236550 90 110352653
Splenic abscess 14.44 9.82 14 236542 986 110351757
Atrioventricular block complete 14.42 9.82 13 236543 20069 110332674
Diarrhoea haemorrhagic 14.41 9.82 69 236487 15570 110337173
Enzyme level abnormal 14.39 9.82 8 236548 235 110352508
Mycobacterial peritonitis 14.39 9.82 8 236548 235 110352508
Carcinoembryonic antigen 14.34 9.82 6 236550 92 110352651
Anorectal discomfort 14.33 9.82 29 236527 4097 110348646
Allergy to animal 14.24 9.82 19 236537 1897 110350846
Bronchopulmonary aspergillosis 14.22 9.82 111 236445 29752 110322991
Leuconostoc infection 14.14 9.82 5 236551 47 110352696
Acute respiratory distress syndrome 14.12 9.82 175 236381 53023 110299720
Purpura 14.12 9.82 95 236461 24293 110328450
Peritoneal adhesions 14.11 9.82 9 236547 342 110352401
Apoptosis 14.09 9.82 12 236544 714 110352029
White blood cell count decreased 14.09 9.82 378 236178 229012 110123731
Hyperkalaemia 14.05 9.82 205 236351 135591 110217152
Bovine tuberculosis 14.03 9.82 7 236549 164 110352579
Glare 14.03 9.82 7 236549 164 110352579
Vascular access site pain 14.00 9.82 11 236545 584 110352159
Vaginal infection 14.00 9.82 39 236517 6765 110345978
Carbohydrate antigen 15-3 13.88 9.82 6 236550 100 110352643
Ear infection 13.88 9.82 78 236478 62654 110290089
Arterial angioplasty 13.87 9.82 5 236551 50 110352693
Hypothyroidism 13.86 9.82 95 236461 72804 110279939
Hyperchlorhydria 13.86 9.82 20 236536 2149 110350594
Hemiplegia 13.83 9.82 17 236539 22765 110329978
Peroneal nerve palsy 13.80 9.82 41 236515 7373 110345370
Seroconversion test positive 13.78 9.82 5 236551 51 110352692
Skin lesion 13.77 9.82 170 236386 51461 110301282
Ileostomy 13.77 9.82 21 236535 2371 110350372
Allergic sinusitis 13.76 9.82 18 236538 1763 110350980
Vulvovaginal candidiasis 13.76 9.82 25 236531 3260 110349483
Glossitis 13.73 9.82 30 236526 4471 110348272
Probiotic therapy 13.72 9.82 7 236549 172 110352571
Rash scarlatiniform 13.72 9.82 9 236547 359 110352384
Complications of transplanted kidney 13.71 9.82 41 236515 7401 110345342
Vulvovaginal swelling 13.71 9.82 11 236545 602 110352141
Joint injury 13.67 9.82 42 236514 39952 110312791
Altered state of consciousness 13.66 9.82 70 236486 57556 110295187
Hepatocellular injury 13.62 9.82 167 236389 50475 110302268
Enterocolonic fistula 13.61 9.82 7 236549 175 110352568
Urine viscosity increased 13.61 9.82 5 236551 53 110352690
Mesenteritis 13.61 9.82 9 236547 364 110352379
Overgrowth bacterial 13.58 9.82 8 236548 263 110352480
Euglycaemic diabetic ketoacidosis 13.56 9.82 4 236552 11619 110341124
Eye infection fungal 13.52 9.82 11 236545 614 110352129
Product use in unapproved indication 13.51 9.82 801 235755 446576 109906167
Increased viscosity of bronchial secretion 13.51 9.82 11 236545 615 110352128
Procalcitonin increased 13.48 9.82 28 236528 4028 110348715
Neurotransmitter level altered 13.47 9.82 4 236552 20 110352723
Penile erythema 13.44 9.82 7 236549 180 110352563
Pyuria 13.42 9.82 22 236534 2641 110350102
Product storage error 13.42 9.82 16 236540 21712 110331031
Palmar-plantar erythrodysaesthesia syndrome 13.38 9.82 44 236512 40981 110311762
Aeromonas test positive 13.38 9.82 3 236553 3 110352740
Visual snow syndrome 13.36 9.82 5 236551 56 110352687
Performance status decreased 13.36 9.82 40 236516 7226 110345517
Enterovesical fistula 13.33 9.82 16 236540 1437 110351306
Stomatococcal infection 13.28 9.82 9 236547 379 110352364
Metabolic disorder 13.26 9.82 51 236505 10459 110342284
Coagulation time prolonged 13.25 9.82 23 236533 2894 110349849
Gastrointestinal wall thickening 13.22 9.82 26 236530 3597 110349146
Resuscitation 13.15 9.82 23 236533 2910 110349833
Pruritus genital 13.04 9.82 37 236519 6485 110346258
Foot amputation 13.03 9.82 14 236542 1114 110351629
Left ventricular hypertrophy 13.02 9.82 6 236550 13238 110339505
Sudden death 13.00 9.82 20 236536 24375 110328368
Pseudopolyp 13.00 9.82 11 236545 649 110352094
Cognitive disorder 12.97 9.82 122 236434 87389 110265354
Photophobia 12.94 9.82 97 236459 25674 110327069
Glycosylated haemoglobin increased 12.94 9.82 19 236537 23600 110329143
Microbiology test abnormal 12.92 9.82 3 236553 4 110352739
Tonsillar haemorrhage 12.88 9.82 8 236548 290 110352453
Peripheral sensory neuropathy 12.86 9.82 70 236486 16610 110336133
Rash pustular 12.85 9.82 58 236498 12771 110339972
Tongue geographic 12.84 9.82 6 236550 121 110352622
Panic disorder 12.83 9.82 25 236531 3436 110349307
Disseminated intravascular coagulation 12.82 9.82 140 236416 41146 110311597
Progressive multifocal leukoencephalopathy 12.79 9.82 21 236535 24935 110327808
Botulism 12.79 9.82 10 236546 527 110352216
Fusarium infection 12.78 9.82 22 236534 2749 110349994
Right ventricle outflow tract obstruction 12.76 9.82 5 236551 64 110352679
Breast discomfort 12.74 9.82 10 236546 530 110352213
Device issue 12.73 9.82 35 236521 34500 110318243
Ligament injury 12.73 9.82 14 236542 1144 110351599
Osteolysis 12.71 9.82 33 236523 5490 110347253
Erythema multiforme 12.71 9.82 83 236473 21014 110331729
Diabetes mellitus inadequate control 12.68 9.82 28 236528 29747 110322996
Injection site rash 12.68 9.82 19 236537 23400 110329343
Renal cancer 12.66 9.82 6 236550 13028 110339715
Kidney infection 12.66 9.82 96 236460 25503 110327240
Ketoacidosis 12.66 9.82 3 236553 10084 110342659
Inappropriate schedule of product administration 12.65 9.82 335 236221 203302 110149441
Abnormal faeces 12.64 9.82 46 236510 9190 110343553
Penile blister 12.62 9.82 5 236551 66 110352677
Hepatic failure 12.62 9.82 212 236344 68527 110284216
Lymphadenectomy 12.62 9.82 16 236540 1520 110351223
Painful respiration 12.61 9.82 26 236530 3721 110349022
Gallbladder fistula 12.59 9.82 4 236552 26 110352717
Enterobacter sepsis 12.55 9.82 15 236541 1341 110351402
Injury 12.54 9.82 286 236270 176979 110175764
Porphyria acute 12.51 9.82 13 236543 18767 110333976
Hyperphosphataemia 12.50 9.82 10 236546 16371 110336372
Haematoma 12.50 9.82 185 236371 58291 110294452
Cardiac failure chronic 12.46 9.82 7 236549 13804 110338939
Gastric cancer 12.46 9.82 4 236552 11004 110341739
Hepatic cirrhosis 12.43 9.82 89 236467 67537 110285206
Ligament rupture 12.42 9.82 27 236529 4008 110348735
Pelvic pain 12.35 9.82 67 236489 15875 110336868
Clostridium colitis 12.35 9.82 24 236532 3291 110349452
Mitochondrial enzyme deficiency 12.34 9.82 4 236552 28 110352715
Personality disorder 12.33 9.82 6 236550 12831 110339912
Glomerulonephritis acute 12.33 9.82 8 236548 313 110352430
Penile oedema 12.31 9.82 8 236548 314 110352429
May-Thurner syndrome 12.29 9.82 5 236551 71 110352672
Drain placement 12.22 9.82 7 236549 218 110352525
Vision blurred 12.21 9.82 362 236194 128660 110224083
Sinus disorder 12.19 9.82 33 236523 32695 110320048
Respiratory tract inflammation 12.14 9.82 13 236543 1030 110351713
Visual impairment 12.14 9.82 375 236181 134053 110218690
Pneumonia fungal 12.11 9.82 63 236493 14691 110338052
Urinary tract infection pseudomonal 12.08 9.82 19 236537 2203 110350540
Liver function test abnormal 12.06 9.82 211 236345 68739 110284004
Agitation 12.04 9.82 322 236234 112729 110240014
Osteopenia 12.04 9.82 18 236538 22191 110330552
Blood creatinine increased 12.02 9.82 492 236064 182397 110170346
Leukaemoid reaction 12.01 9.82 9 236547 445 110352298
Hyperlipidaemia 12.01 9.82 38 236518 35810 110316933
Colour blindness 11.96 9.82 10 236546 580 110352163
Pelvi-ureteric obstruction 11.93 9.82 8 236548 331 110352412
Coagulopathy 11.92 9.82 137 236419 40774 110311969
Cardiac disorder 11.89 9.82 105 236451 76175 110276568
Blood disorder 11.89 9.82 47 236509 9763 110342980
Metastases to central nervous system 11.88 9.82 19 236537 22798 110329945
Cerebellar syndrome 11.88 9.82 35 236521 6267 110346476
Colour blindness acquired 11.85 9.82 6 236550 145 110352598
Gallbladder rupture 11.85 9.82 14 236542 1236 110351507
Vulval abscess 11.78 9.82 12 236544 897 110351846
Keratitis bacterial 11.78 9.82 7 236549 234 110352509
Intestinal perforation 11.77 9.82 81 236475 20863 110331880
Sense of oppression 11.73 9.82 16 236540 1632 110351111
Concussion 11.70 9.82 5 236551 11533 110341210
Basophil count abnormal 11.67 9.82 4 236552 34 110352709
Colonic abscess 11.63 9.82 17 236539 1848 110350895
Pelvic fracture 11.63 9.82 8 236548 14146 110338597
Faecal calprotectin abnormal 11.62 9.82 8 236548 346 110352397
Bacterial infection 11.61 9.82 150 236406 45886 110306857
Gynaecomastia 11.56 9.82 3 236553 9487 110343256
Acid base balance abnormal 11.55 9.82 9 236547 472 110352271
Paranasal sinus discomfort 11.53 9.82 35 236521 6370 110346373
Red blood cell count decreased 11.53 9.82 88 236468 65835 110286908
Gallbladder polyp 11.52 9.82 14 236542 1273 110351470
Gallbladder injury 11.51 9.82 14 236542 1274 110351469
Oxygen saturation decreased 11.47 9.82 252 236304 156730 110196013
Candida osteomyelitis 11.47 9.82 4 236552 36 110352707
Device difficult to use 11.45 9.82 14 236542 18791 110333952
Hypercalcaemia 11.45 9.82 56 236500 46601 110306142
Hypopnoea 11.43 9.82 5 236551 11375 110341368
Lip oedema 11.39 9.82 39 236517 7561 110345182
Epicondylitis 11.38 9.82 20 236536 2540 110350203
Corneal infiltrates 11.38 9.82 8 236548 358 110352385
Respiratory tract oedema 11.35 9.82 13 236543 1110 110351633
Ankylosing spondylitis 11.34 9.82 10 236546 15602 110337141
Rhinorrhoea 11.32 9.82 153 236403 102513 110250230
Peripheral artery dissection 11.31 9.82 3 236553 9 110352734
Histamine abnormal 11.31 9.82 3 236553 9 110352734
Gastroenteritis yersinia 11.31 9.82 3 236553 9 110352734
Cardiac failure 11.31 9.82 310 236246 187316 110165427
Back disorder 11.30 9.82 17 236539 20905 110331838
Subdural haematoma 11.28 9.82 40 236516 36414 110316329
Clostridium bacteraemia 11.27 9.82 9 236547 489 110352254
Biopsy colon abnormal 11.17 9.82 5 236551 91 110352652
Skin warm 11.16 9.82 44 236512 9126 110343617
Mucosal ulceration 11.12 9.82 19 236537 2360 110350383
Occupational exposure to air contaminants 11.12 9.82 6 236550 166 110352577
Joint instability 11.09 9.82 16 236540 1719 110351024
Renal pain 11.07 9.82 46 236510 9771 110342972
Metatarsal excision 11.07 9.82 3 236553 10 110352733
Induration 11.06 9.82 19 236537 2370 110350373
Hepatic function abnormal 10.99 9.82 130 236426 89165 110263578
Bundle branch block left 10.97 9.82 7 236549 12881 110339862
Spinal fusion surgery 10.96 9.82 3 236553 9153 110343590
Left ventricular dysfunction 10.93 9.82 21 236535 23472 110329271
Vulvovaginal pain 10.89 9.82 21 236535 2863 110349880
Calculus bladder 10.89 9.82 16 236540 1748 110350995
Colorectal cancer 10.88 9.82 3 236553 9111 110343632
Aortic dissection 10.87 9.82 29 236527 4904 110347839
Cataract 10.86 9.82 113 236443 79372 110273371
Cerebral ischaemia 10.86 9.82 53 236503 12051 110340692
Actinomycotic skin infection 10.85 9.82 3 236553 11 110352732
Measles 10.85 9.82 10 236546 661 110352082
Intestinal ulcer 10.84 9.82 19 236537 2408 110350335
Aerococcus urinae infection 10.84 9.82 4 236552 43 110352700
Testicular pain 10.83 9.82 19 236537 2410 110350333
Meningitis bacterial 10.82 9.82 22 236534 3117 110349626
Burnout syndrome 10.81 9.82 8 236548 388 110352355
Circulatory collapse 10.80 9.82 140 236416 42853 110309890
Mucosal disorder 10.80 9.82 27 236529 4390 110348353
Gastrointestinal stoma output increased 10.79 9.82 12 236544 992 110351751
Culture stool positive 10.76 9.82 10 236546 668 110352075
Burning mouth syndrome 10.72 9.82 10 236546 671 110352072
Oesophageal candidiasis 10.71 9.82 51 236505 11483 110341260
Dyslipidaemia 10.69 9.82 11 236545 15954 110336789
Injection site streaking 10.67 9.82 4 236552 45 110352698
Nephrolithiasis 10.66 9.82 200 236356 66012 110286731
Perirectal abscess 10.65 9.82 18 236538 2216 110350527
Vertebral artery hypoplasia 10.65 9.82 3 236553 12 110352731
Roseola 10.65 9.82 3 236553 12 110352731
Drug dependence 10.63 9.82 63 236493 49957 110302786
Enterococcal bacteraemia 10.63 9.82 27 236529 4434 110348309
Urethral stenosis 10.62 9.82 13 236543 1191 110351552
Injection site eczema 10.61 9.82 5 236551 103 110352640
Creatinine renal clearance decreased 10.59 9.82 19 236537 21796 110330947
Medication error 10.57 9.82 160 236396 105206 110247537
Lower respiratory tract inflammation 10.56 9.82 6 236550 184 110352559
Paranasal sinus hyposecretion 10.56 9.82 6 236550 184 110352559
Urge incontinence 10.47 9.82 14 236542 1401 110351342
Asphyxia 10.45 9.82 9 236547 14206 110338537
Capnocytophaga infection 10.44 9.82 6 236550 188 110352555
Prolapse 10.44 9.82 4 236552 48 110352695
Convulsive threshold lowered 10.39 9.82 12 236544 1034 110351709
Delayed graft function 10.39 9.82 26 236530 4231 110348512
Cardiac discomfort 10.37 9.82 14 236542 1414 110351329
Abortion spontaneous 10.35 9.82 38 236518 34244 110318499
Respiratory symptom 10.35 9.82 10 236546 14935 110337808
Hepatic amoebiasis 10.35 9.82 5 236551 109 110352634
Infective exacerbation of bronchiectasis 10.34 9.82 11 236545 865 110351878
Nikolsky's sign 10.33 9.82 6 236550 192 110352551
Paranasal sinus inflammation 10.31 9.82 7 236549 296 110352447
Organ failure 10.30 9.82 28 236528 4789 110347954
Tendon calcification 10.27 9.82 6 236550 194 110352549
Clostridial sepsis 10.25 9.82 12 236544 1049 110351694
Gastrointestinal mucosa hyperaemia 10.24 9.82 9 236547 559 110352184
Blood uric acid increased 10.23 9.82 19 236537 21510 110331233
Bicuspid aortic valve 10.22 9.82 4 236552 51 110352692
Incorrect dose administered 10.19 9.82 158 236398 103483 110249260
Renal tubular disorder 10.16 9.82 37 236519 7392 110345351
Akathisia 10.15 9.82 13 236543 17100 110335643
Panniculitis 10.14 9.82 11 236545 15571 110337172
Macroglossia 10.12 9.82 14 236542 1447 110351296
Blood catecholamines decreased 10.11 9.82 3 236553 15 110352728
Tooth fracture 10.10 9.82 8 236548 13159 110339584
Dermatitis atopic 10.09 9.82 25 236531 25516 110327227
Product complaint 10.09 9.82 9 236547 13963 110338780
Ballismus 10.06 9.82 7 236549 308 110352435
Bradypnoea 10.04 9.82 3 236553 8646 110344097
Pruritus allergic 9.97 9.82 15 236541 1673 110351070
Orchitis noninfective 9.95 9.82 3 236553 16 110352727
Prostatic cyst 9.95 9.82 3 236553 16 110352727
Confusional state 9.94 9.82 865 235691 467815 109884928
Carotid artery occlusion 9.93 9.82 4 236552 9561 110343182
Renal papillary necrosis 9.92 9.82 8 236548 441 110352302
Rash 9.89 9.82 1945 234611 819019 109533724
Urethral pain 9.89 9.82 9 236547 585 110352158
Syringe issue 9.86 9.82 4 236552 9521 110343222

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MA02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
ATC J01RA10 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J01RA11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J01RA12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC S01AE03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Fluoroquinolones
ATC S02AA15 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA07 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
FDA CS M0372253 Fluoroquinolones
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D065609 Cytochrome P-450 CYP1A2 Inhibitors
FDA MoA N0000182138 Cytochrome P450 1A2 Inhibitors
FDA EPC N0000193223 Fluoroquinolone Antibacterial
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50750 EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
CHEBI has role CHEBI:53559 topoisomerase IV inhibitor
CHEBI has role CHEBI:55323 antidiarrhoeal drug
CHEBI has role CHEBI:59517 DNA synthesis inhibitor
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

J01MA Fluoroquinolones 22 drugs
delafloxacinenoxacinfleroxacingarenoxacingatifloxacingemifloxacingrepafloxacinlascufloxacinlevofloxacinlomefloxacinmoxifloxacinnorfloxacin show all 22 →
J01RA Combinations of antibacterials 18 drugs
amikacinazithromycincefepimecefiximecefuroximefluconazolelevofloxacinmetronidazolenitazoxanidenorfloxacinnystatinofloxacin show all 18 →
S01AE Fluoroquinolones 8 drugs
besifloxacingatifloxacinlevofloxacinlomefloxacinmoxifloxacinnorfloxacinofloxacintosufloxacin
S02AA Antiinfectives 17 drugs
acetic acidaluminium acetotartrateboric acidcefmenoximechloramphenicolchlorhexidineclioquinolfosfomycingentamicinhydrogen peroxidemiconazoleneomycin show all 17 →
S03AA Antiinfectives 7 drugs
chloramphenicolchlorhexidinegentamicinhexamidineneomycinPolymyxin Btetracycline

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Typhoid fever indication 4834000 DOID:13258
Septicemia due to Escherichia coli indication 9323009
Prostatitis indication 9713002 DOID:14654
Infection due to Pseudomonas aeruginosa indication 11218009
Enteric campylobacteriosis indication 18081009
Infectious diarrheal disease indication 19213003 DOID:13250
Infection of skin AND/OR subcutaneous tissue indication 19824006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Acute gonococcal urethritis indication 29864006
Acute bacterial peritonitis indication 31860008
Pneumonia due to Streptococcus indication 34020007
Shigellosis indication 36188001
Cystitis indication 38822007 DOID:1679
Pneumonia due to Pseudomonas indication 41381004
Lower respiratory tract infection indication 50417007
Pneumonia due to Escherichia coli indication 51530003
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Acute maxillary sinusitis indication 68272006 DOID:2050
Haemophilus influenzae pneumonia indication 70036007
Infection due to Escherichia coli indication 71057007
Rhinoscleroma indication 72409005 DOID:11336
Abdominal abscess indication 75100008
Acute bacterial sinusitis indication 75498004
Infective otitis externa indication 86981007 DOID:9463
Infection of bone indication 111253001
Infectious disease of abdomen indication 128070006
Bacterial conjunctivitis indication 128350005 DOID:9700
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Acute Moraxella catarrhalis bronchitis indication 195722003
Proteus pneumonia indication 195888009
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Acute bacterial bronchitis indication 233598009
Infective cystitis indication 236620008
Chancroid indication 266143009 DOID:13778
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Infectious disorder of joint indication 363162000
Infection due to Staphylococcus aureus indication 406602003
Anthrax indication 409498004 DOID:7427
Acute osteomyelitis indication 409780002
Nosocomial pneumonia indication 425464007
Urinary tract infection caused by Klebsiella indication 369001000119100
Skin and Skin Structure Pseudomonas Aeruginosa Infection indication
Complicated UTI with Pseudomonas Aeruginosa indication
Staphylococcus Epidermidis Urinary Tract Infection indication
Pseudomonas Aeruginosa Joint Infection indication
Complicated Proteus UTI indication
Skin and Skin Structure Providencia Infection indication
Complicated Bacterial Peritonitis indication
Staphylococcus Saprophyticus Urinary Tract Infection indication
Haemophilus Parainfluenzae Pneumonia indication
Enterobacter Pneumonia indication
Skin and Skin Structure Citrobacter Infection indication
Moraxella Catarrhalis Chronic Bronchitis indication
Diarrhea due to E. Coli indication
Klebsiella Nosocomial Pneumonia indication
Citrobacter Urinary Tract Infection indication
Enterococcus Urinary Tract Infection indication
Serratia Joint Infection indication
Skin and Skin Structure Proteus Infection indication
EnterobacterJoint Infection indication
Enterobacter Osteomyelitis indication
Nosocomial Pneumonia due to Haemophilus Influenzae indication
Complicated Bacteroides Peritonitis indication
Complicated E. Coli Peritonitis indication
Morganella Morganii Urinary Tract Infection indication
Bacterial Corneal Ulcer Infection indication
E. Coli Cystitis indication
Staphylococcus Aureus Otitis Externa indication
Staphylococcus Cystitis indication
Chronic Bacterial Prostatitis indication
Pseudomonas Aeruginosa Urinary Tract Infection indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Serratia Osteomyelitis indication
Staphylococcus Epidermidis Skin and Skin Structure Infection indication
Enterococcus Complicated UTI indication
Providencia Urinary Tract Infection indication
Complicated Klebsiella Peritonitis indication
Skin and Skin Structure Serratia Infection indication
Proteus Prostatitis indication
E. Coli Pyelonephritis indication
Skin and Skin Structure Morganella Morganii Infection indication
Serratia Urinary Tract Infection indication
Pseudomonas Aeruginosa Osteomyelitis indication
Inhalational anthrax off-label use 11389007
Traveler's diarrhea off-label use 11840006
Salmonella septicemia off-label use 49786009
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Diverticulitis of gastrointestinal tract off-label use 271366000
Ventilator-acquired pneumonia off-label use 429271009
Diabetic Foot Infection off-label use
Prevention of Meningococcal Meningitis off-label use
Achilles tendinitis contraindication 11654001
Lowered convulsive threshold contraindication 19260006
Torsades de pointes contraindication 31722008
Transplantation of heart contraindication 32413006
Tendinitis contraindication 34840004 DOID:971
Hypokalemia contraindication 43339004
Transplant of kidney contraindication 70536003
Epilepsy contraindication 84757009 DOID:1826
Transplant of lung contraindication 88039007
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Superimposed infection contraindication 193198003
Peripheral nerve disease contraindication 302226006
Viral ear infection contraindication 312137007
Pseudomembranous enterocolitis contraindication 397683000
Traumatic rupture of tendon contraindication 415749005
Congenital long QT syndrome contraindication 442917000
Shoulder Tendonitis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.12 acidic
pKa2 8.54 Basic
pKa3 1.37 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
6% (60MG/ML) OTIPRIO ALK ABELLO N207986 Dec. 10, 2015 DISCN INJECTABLE, SUSPENSION OTIC 9205048 April 21, 2029 TREATMENT OF PEDIATRIC PATIENTS WITH OTITIS MEDIA WITH EFFUSION UNDERGOING TYMPANOSTOMY TUBE PLACEMENT
6% (60MG/ML) OTIPRIO ALK ABELLO N207986 Dec. 10, 2015 DISCN INJECTABLE, SUSPENSION OTIC 9603796 April 21, 2029 THE TREATMENT OF ACUTE OTITIS EXTERNA IN PATIENTS 6 MONTHS OF AGE AND OLDER DUE TO PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS
EQ 0.3% BASE;0.025% OTOVEL LAB SALVAT N208251 April 29, 2016 RX SOLUTION/DROPS OTIC 8932610 March 24, 2030 TREATMENT OF ACUTE OTITIS MEDIA
6% (60MG/ML) OTIPRIO ALK ABELLO N207986 Dec. 10, 2015 DISCN INJECTABLE, SUSPENSION OTIC 8318817 April 27, 2030 TREATMENT OF OTIC INFECTION OR INFLAMMATION
6% (60MG/ML) OTIPRIO ALK ABELLO N207986 Dec. 10, 2015 DISCN INJECTABLE, SUSPENSION OTIC 11040004 Nov. 12, 2037 THE TREATMENT OF ACUTE OTITIS EXTERNA IN PATIENTS 6 MONTHS OF AGE AND OLDER DUE TO PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 0.2% BASE;1% CIPROFLOXACIN HYDROCHLORIDE AND HYDROCORTISONE COSETTE PHARMS NC A218273 Nov. 10, 2025 RX SUSPENSION/DROPS OTIC June 2, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA topoisomerase II Enzyme EC50 7.52 CHEMBL
DNA gyrase subunit A Enzyme INHIBITOR IC50 5.75 WOMBAT-PK CHEMBL
DNA topoisomerase 4 subunit A Enzyme IC50 5.66 WOMBAT-PK
DNA topoisomerase 4 subunit A Enzyme INHIBITOR IC50 6 WOMBAT-PK
DNA gyrase subunit A Enzyme IC50 6.20 WOMBAT-PK
Histamine H3 receptor GPCR Ki 9.18 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 6.39 CHEMBL
Multidrug resistance protein mdtK Transporter Kd 4.04 CHEMBL
DNA gyrase subunit B Enzyme IC50 5.93 CHEMBL
DNA topoisomerase 4 subunit A Enzyme IC50 5.60 WOMBAT-PK
DNA topoisomerase 4 subunit B Enzyme IC50 4.62 CHEMBL

External reference:

IDSource
4019307 VUID
N0000147503 NUI
D00186 KEGG_DRUG
86393-32-0 SECONDARY_CAS_RN
235851 RXNORM
C0008809 UMLSCUI
CHEBI:100241 CHEBI
CPF PDB_CHEM_ID
CHEMBL8 ChEMBL_ID
CHEMBL1202 ChEMBL_ID
DB00537 DRUGBANK_ID
D002939 MESH_DESCRIPTOR_UI
2764 PUBCHEM_CID
10902 IUPHAR_LIGAND_ID
5446 INN_ID
5E8K9I0O4U UNII
31644 MMSL
4451 MMSL
4452 MMSL
46904 MMSL
76342 MMSL
d00011 MMSL
002882 NDDF
003577 NDDF
004125 NDDF
20450009 SNOMEDCT_US
372840008 SNOMEDCT_US
428384006 SNOMEDCT_US
7577004 SNOMEDCT_US
CHEMBL1077975 ChEMBL_ID
97867-33-9 SECONDARY_CAS_RN
4019306 VANDF
4019307 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CILOXAN HUMAN PRESCRIPTION DRUG LABEL 1 0078-0841 OINTMENT 3 mg OPHTHALMIC NDA 20 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9927 TABLET, FILM COATED 250 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9928 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9929 TABLET, FILM COATED 750 mg ORAL ANDA 30 sections
Ciprofloxacin in Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-2300 INJECTION, SOLUTION 200 mg INTRAVENOUS ANDA 33 sections
Ciprofloxacin in Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-3300 INJECTION, SOLUTION 400 mg INTRAVENOUS ANDA 33 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8546 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8630 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
ciprofloxacin hydrochloride and hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 2 0713-0851 SUSPENSION/ DROPS 2 mg AURICULAR (OTIC) ANDA 16 sections
Ciprofloxacin and Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 2 0781-6186 SUSPENSION/ DROPS 3 mg AURICULAR (OTIC) NDA authorized generic 26 sections
ciprofloxacin hydrochloride and hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 2 0781-6218 SUSPENSION/ DROPS 2 mg AURICULAR (OTIC) NDA authorized generic 16 sections
Ciprofloxacin and Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 2 0832-1430 SUSPENSION 3 mg AURICULAR (OTIC) ANDA 29 sections
ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-7243 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-036 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-079 TABLET 500 mg ORAL ANDA 27 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-147 TABLET, FILM COATED 250 mg ORAL ANDA 27 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-432 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-603 TABLET 250 mg ORAL ANDA 27 sections
CIPROFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 10544-604 TABLET, FILM COATED 250 mg ORAL ANDA 28 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-605 TABLET, FILM COATED 500 mg ORAL ANDA 17 sections
Ciprofloxacin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-606 TABLET 500 mg ORAL ANDA 25 sections
CIPROFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 10544-607 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-608 TABLET 500 mg ORAL ANDA 27 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-673 TABLET, FILM COATED 250 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-884 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-943 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 11819-323 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 11819-351 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 11819-360 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 11819-363 TABLET, FILM COATED 500 mg ORAL ANDA 18 sections