Stem definition | Drug id | CAS RN |
---|---|---|
antibacterials, nalidixic acid derivatives | 659 | 85721-33-1 |
Dose | Unit | Route |
---|---|---|
1 | g | O |
0.80 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.15 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 65 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 34.49 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 8.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.70 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 3.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 22, 1987 | FDA | BAYER HLTHCARE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 1193.66 | 9.49 | 2045 | 103798 | 241780 | 46338439 |
Tendon pain | 616.24 | 9.49 | 235 | 105608 | 2615 | 46577604 |
Tendonitis | 535.28 | 9.49 | 358 | 105485 | 13919 | 46566300 |
Abortion spontaneous | 385.58 | 9.49 | 485 | 105358 | 43161 | 46537058 |
Drug reaction with eosinophilia and systemic symptoms | 279.64 | 9.49 | 340 | 105503 | 29208 | 46551011 |
Rheumatoid arthritis | 276.05 | 9.49 | 100 | 105743 | 240115 | 46340104 |
Tendon rupture | 251.68 | 9.49 | 178 | 105665 | 7581 | 46572638 |
Toxic epidermal necrolysis | 213.47 | 9.49 | 258 | 105585 | 22020 | 46558199 |
Tendon disorder | 193.80 | 9.49 | 128 | 105715 | 4867 | 46575352 |
Tubulointerstitial nephritis | 183.75 | 9.49 | 196 | 105647 | 14592 | 46565627 |
Drug interaction | 179.66 | 9.49 | 922 | 104921 | 202172 | 46378047 |
Pathogen resistance | 169.24 | 9.49 | 127 | 105716 | 5933 | 46574286 |
Drug ineffective | 141.93 | 9.49 | 929 | 104914 | 676909 | 45903310 |
Clostridium difficile colitis | 134.16 | 9.49 | 187 | 105656 | 18366 | 46561853 |
Death | 132.15 | 9.49 | 360 | 105483 | 335188 | 46245031 |
Acute kidney injury | 128.08 | 9.49 | 944 | 104899 | 234911 | 46345308 |
Completed suicide | 121.35 | 9.49 | 92 | 105751 | 145828 | 46434391 |
Dysbiosis | 104.05 | 9.49 | 41 | 105802 | 501 | 46579718 |
Cholecystitis chronic | 102.86 | 9.49 | 123 | 105720 | 10376 | 46569843 |
Urinary tract infection | 97.82 | 9.49 | 842 | 105001 | 219424 | 46360795 |
Clostridium difficile infection | 88.90 | 9.49 | 184 | 105659 | 24919 | 46555300 |
Fall | 88.78 | 9.49 | 414 | 105429 | 328683 | 46251536 |
Stevens-Johnson syndrome | 87.53 | 9.49 | 175 | 105668 | 23122 | 46557097 |
Pemphigus | 85.71 | 9.49 | 4 | 105839 | 45270 | 46534949 |
Tinnitus | 78.95 | 9.49 | 186 | 105657 | 27487 | 46552732 |
Tendon discomfort | 78.59 | 9.49 | 23 | 105820 | 101 | 46580118 |
Early retirement | 77.90 | 9.49 | 16 | 105827 | 4 | 46580215 |
Injection site pain | 77.59 | 9.49 | 77 | 105766 | 107075 | 46473144 |
Therapeutic product effect decreased | 71.33 | 9.49 | 50 | 105793 | 82551 | 46497668 |
Myalgia | 68.56 | 9.49 | 496 | 105347 | 122592 | 46457627 |
Hand deformity | 65.62 | 9.49 | 3 | 105840 | 34571 | 46545648 |
Paraesthesia | 64.70 | 9.49 | 472 | 105371 | 116965 | 46463254 |
Drug resistance | 64.69 | 9.49 | 130 | 105713 | 17238 | 46562981 |
Geotrichum infection | 64.48 | 9.49 | 28 | 105815 | 444 | 46579775 |
Injury | 64.42 | 9.49 | 233 | 105610 | 43794 | 46536425 |
Joint noise | 63.87 | 9.49 | 55 | 105788 | 3132 | 46577087 |
Panic attack | 63.21 | 9.49 | 141 | 105702 | 20101 | 46560118 |
Musculoskeletal injury | 60.74 | 9.49 | 19 | 105824 | 109 | 46580110 |
Intentional overdose | 60.59 | 9.49 | 36 | 105807 | 64908 | 46515311 |
Rash maculo-papular | 60.49 | 9.49 | 169 | 105674 | 27705 | 46552514 |
Disturbance in attention | 60.46 | 9.49 | 183 | 105660 | 31377 | 46548842 |
Multiple organ dysfunction syndrome | 59.71 | 9.49 | 254 | 105589 | 51456 | 46528763 |
Therapeutic product effect incomplete | 59.09 | 9.49 | 54 | 105789 | 78099 | 46502120 |
Pseudomembranous colitis | 55.79 | 9.49 | 51 | 105792 | 3144 | 46577075 |
Connective tissue disorder | 54.51 | 9.49 | 32 | 105811 | 984 | 46579235 |
Injection site erythema | 54.42 | 9.49 | 53 | 105790 | 74374 | 46505845 |
Off label use | 54.30 | 9.49 | 575 | 105268 | 379266 | 46200953 |
Tendon injury | 53.58 | 9.49 | 37 | 105806 | 1515 | 46578704 |
Febrile neutropenia | 53.07 | 9.49 | 382 | 105461 | 94245 | 46485974 |
Pouchitis | 52.97 | 9.49 | 24 | 105819 | 423 | 46579796 |
Contraindicated product administered | 52.81 | 9.49 | 62 | 105781 | 79885 | 46500334 |
Synovitis | 52.68 | 9.49 | 37 | 105806 | 61038 | 46519181 |
Neuropathy peripheral | 52.17 | 9.49 | 369 | 105474 | 90524 | 46489695 |
Multiple chemical sensitivity | 51.90 | 9.49 | 11 | 105832 | 5 | 46580214 |
Pseudomonas infection | 51.56 | 9.49 | 85 | 105758 | 9673 | 46570546 |
Torsade de pointes | 50.16 | 9.49 | 95 | 105748 | 12059 | 46568160 |
Glossodynia | 49.96 | 9.49 | 19 | 105824 | 44354 | 46535865 |
Dermatitis exfoliative | 49.60 | 9.49 | 63 | 105780 | 5653 | 46574566 |
Drug intolerance | 49.01 | 9.49 | 170 | 105673 | 146879 | 46433340 |
Nasopharyngitis | 48.70 | 9.49 | 182 | 105661 | 153816 | 46426403 |
Product dose omission issue | 48.34 | 9.49 | 207 | 105636 | 168313 | 46411906 |
Emotional distress | 47.05 | 9.49 | 165 | 105678 | 30542 | 46549677 |
Fistula | 46.74 | 9.49 | 73 | 105770 | 7937 | 46572282 |
Food intolerance | 46.24 | 9.49 | 40 | 105803 | 2292 | 46577927 |
Psoriasis | 45.72 | 9.49 | 67 | 105776 | 78537 | 46501682 |
Renal tubular necrosis | 45.52 | 9.49 | 85 | 105758 | 10674 | 46569545 |
Drug abuse | 45.38 | 9.49 | 46 | 105797 | 63362 | 46516857 |
Pyrexia | 45.33 | 9.49 | 1072 | 104771 | 347730 | 46232489 |
Burning sensation | 45.12 | 9.49 | 210 | 105633 | 44201 | 46536018 |
Pyelonephritis | 44.65 | 9.49 | 104 | 105739 | 15253 | 46564966 |
Toxicity to various agents | 43.07 | 9.49 | 292 | 105551 | 211474 | 46368745 |
Injection site swelling | 42.60 | 9.49 | 19 | 105824 | 40308 | 46539911 |
Device expulsion | 42.40 | 9.49 | 6 | 105837 | 27536 | 46552683 |
Wrong technique in product usage process | 41.86 | 9.49 | 37 | 105806 | 54385 | 46525834 |
Diverticulitis | 41.84 | 9.49 | 167 | 105676 | 32872 | 46547347 |
Intentional product misuse | 41.38 | 9.49 | 28 | 105815 | 47100 | 46533119 |
Anxiety | 40.93 | 9.49 | 609 | 105234 | 181348 | 46398871 |
Weight increased | 40.73 | 9.49 | 213 | 105630 | 164260 | 46415959 |
Abdominal pain | 40.68 | 9.49 | 740 | 105103 | 229291 | 46350928 |
Impaired work ability | 40.55 | 9.49 | 89 | 105754 | 12547 | 46567672 |
Trimethylaminuria | 40.40 | 9.49 | 15 | 105828 | 154 | 46580065 |
Infusion related reaction | 40.14 | 9.49 | 108 | 105735 | 101100 | 46479119 |
Asthma | 39.15 | 9.49 | 94 | 105749 | 91448 | 46488771 |
Cystitis | 38.77 | 9.49 | 194 | 105649 | 42047 | 46538172 |
Injection site reaction | 38.68 | 9.49 | 31 | 105812 | 47818 | 46532401 |
Anal abscess | 38.58 | 9.49 | 44 | 105799 | 3528 | 46576691 |
Anal fistula | 38.21 | 9.49 | 38 | 105805 | 2603 | 46577616 |
Acute generalised exanthematous pustulosis | 38.18 | 9.49 | 73 | 105770 | 9332 | 46570887 |
Cardio-respiratory arrest | 37.87 | 9.49 | 48 | 105795 | 59821 | 46520398 |
Breast cancer | 37.41 | 9.49 | 29 | 105814 | 45489 | 46534730 |
Suicide attempt | 37.08 | 9.49 | 42 | 105801 | 54994 | 46525225 |
Muscle atrophy | 36.97 | 9.49 | 56 | 105787 | 5928 | 46574291 |
Biliary dyskinesia | 36.66 | 9.49 | 38 | 105805 | 2735 | 46577484 |
Alopecia | 35.53 | 9.49 | 219 | 105624 | 162195 | 46418024 |
Arthropathy | 35.41 | 9.49 | 88 | 105755 | 84612 | 46495607 |
Segmental diverticular colitis | 35.31 | 9.49 | 13 | 105830 | 130 | 46580089 |
Aspergillus infection | 35.04 | 9.49 | 59 | 105784 | 6831 | 46573388 |
Therapeutic response decreased | 34.81 | 9.49 | 28 | 105815 | 43117 | 46537102 |
Pulmonary eosinophilia | 34.65 | 9.49 | 15 | 105828 | 236 | 46579983 |
Pedal pulse abnormal | 34.37 | 9.49 | 13 | 105830 | 141 | 46580078 |
Psoriatic arthropathy | 34.16 | 9.49 | 20 | 105823 | 36359 | 46543860 |
Weight bearing difficulty | 33.66 | 9.49 | 33 | 105810 | 2222 | 46577997 |
Factor V inhibition | 33.35 | 9.49 | 13 | 105830 | 154 | 46580065 |
Nephritis allergic | 33.35 | 9.49 | 13 | 105830 | 154 | 46580065 |
Ectropion | 32.69 | 9.49 | 13 | 105830 | 163 | 46580056 |
Anti-cyclic citrullinated peptide antibody positive | 32.40 | 9.49 | 3 | 105840 | 19142 | 46561077 |
Muscular weakness | 32.12 | 9.49 | 334 | 105509 | 91510 | 46488709 |
Factor V deficiency | 31.72 | 9.49 | 11 | 105832 | 91 | 46580128 |
Injection site bruising | 31.51 | 9.49 | 21 | 105822 | 35615 | 46544604 |
Osteoporosis | 30.76 | 9.49 | 28 | 105815 | 40580 | 46539639 |
Gastroenteritis pseudomonas | 30.55 | 9.49 | 6 | 105837 | 0 | 46580219 |
Fat tissue decreased | 30.32 | 9.49 | 7 | 105836 | 8 | 46580211 |
Infective pulmonary exacerbation of cystic fibrosis | 30.13 | 9.49 | 72 | 105771 | 10735 | 46569484 |
Loss of employment | 30.01 | 9.49 | 24 | 105819 | 1232 | 46578987 |
Colitis | 29.79 | 9.49 | 165 | 105678 | 37182 | 46543037 |
Chronic kidney disease | 29.61 | 9.49 | 176 | 105667 | 40695 | 46539524 |
Systemic lupus erythematosus | 29.42 | 9.49 | 65 | 105778 | 65115 | 46515104 |
Muscle twitching | 28.97 | 9.49 | 86 | 105757 | 14586 | 46565633 |
Drug-induced liver injury | 28.80 | 9.49 | 124 | 105719 | 25244 | 46554975 |
Knee arthroplasty | 28.59 | 9.49 | 9 | 105834 | 23656 | 46556563 |
Joint swelling | 28.52 | 9.49 | 240 | 105603 | 165833 | 46414386 |
Injection site pruritus | 28.24 | 9.49 | 29 | 105814 | 39714 | 46540505 |
Thrombocytopenia | 28.18 | 9.49 | 423 | 105420 | 126158 | 46454061 |
Calcium ionised decreased | 28.15 | 9.49 | 13 | 105830 | 240 | 46579979 |
Sphingomonas paucimobilis infection | 28.12 | 9.49 | 6 | 105837 | 3 | 46580216 |
Bacterial colitis | 28.02 | 9.49 | 9 | 105834 | 57 | 46580162 |
Headache | 27.91 | 9.49 | 849 | 104994 | 477503 | 46102716 |
Nerve injury | 27.89 | 9.49 | 57 | 105786 | 7648 | 46572571 |
Moraxella test positive | 27.66 | 9.49 | 7 | 105836 | 15 | 46580204 |
Mineral deficiency | 27.35 | 9.49 | 7 | 105836 | 16 | 46580203 |
Coma | 27.32 | 9.49 | 57 | 105786 | 58292 | 46521927 |
Muscle contractions involuntary | 27.30 | 9.49 | 28 | 105815 | 1990 | 46578229 |
Anorectal ulcer | 27.13 | 9.49 | 9 | 105834 | 64 | 46580155 |
Non-consummation | 27.13 | 9.49 | 9 | 105834 | 64 | 46580155 |
Bladder pain | 27.04 | 9.49 | 24 | 105819 | 1423 | 46578796 |
Procedural anxiety | 26.74 | 9.49 | 16 | 105827 | 510 | 46579709 |
Malignant neoplasm progression | 26.71 | 9.49 | 68 | 105775 | 64858 | 46515361 |
Wound | 26.36 | 9.49 | 35 | 105808 | 42767 | 46537452 |
Osteochondrosis | 26.35 | 9.49 | 20 | 105823 | 950 | 46579269 |
Linear IgA disease | 26.29 | 9.49 | 23 | 105820 | 1338 | 46578881 |
Klebsiella infection | 26.17 | 9.49 | 51 | 105792 | 6611 | 46573608 |
Fungaemia | 25.81 | 9.49 | 27 | 105816 | 1964 | 46578255 |
Mitochondrial cytopathy | 25.79 | 9.49 | 13 | 105830 | 293 | 46579926 |
Megacolon | 25.71 | 9.49 | 25 | 105818 | 1666 | 46578553 |
Pericarditis | 25.70 | 9.49 | 11 | 105832 | 23916 | 46556303 |
Flank pain | 25.62 | 9.49 | 72 | 105771 | 11841 | 46568378 |
Hyperacusis | 25.47 | 9.49 | 26 | 105817 | 1838 | 46578381 |
Inappropriate schedule of product administration | 25.30 | 9.49 | 70 | 105773 | 64943 | 46515276 |
Intentional product use issue | 25.19 | 9.49 | 51 | 105792 | 52729 | 46527490 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 25.18 | 9.49 | 15 | 105828 | 474 | 46579745 |
Acute hepatic failure | 25.10 | 9.49 | 82 | 105761 | 14639 | 46565580 |
Neutropenia | 24.68 | 9.49 | 459 | 105384 | 142745 | 46437474 |
Enterococcal infection | 24.48 | 9.49 | 51 | 105792 | 6936 | 46573283 |
Chemical burns of eye | 24.35 | 9.49 | 8 | 105835 | 55 | 46580164 |
Cardiac failure congestive | 24.31 | 9.49 | 116 | 105727 | 91634 | 46488585 |
Hypertension | 24.18 | 9.49 | 307 | 105536 | 196049 | 46384170 |
Blood pressure increased | 24.09 | 9.49 | 178 | 105665 | 126488 | 46453731 |
Pregnancy | 23.98 | 9.49 | 16 | 105827 | 27121 | 46553098 |
Idiopathic intracranial hypertension | 23.93 | 9.49 | 29 | 105814 | 2480 | 46577739 |
Treatment failure | 23.90 | 9.49 | 119 | 105724 | 92968 | 46487251 |
Accidental exposure to product | 23.77 | 9.49 | 9 | 105834 | 21072 | 46559147 |
Hip arthroplasty | 23.53 | 9.49 | 6 | 105837 | 18106 | 46562113 |
Gastrointestinal scarring | 23.43 | 9.49 | 11 | 105832 | 211 | 46580008 |
Total lung capacity increased | 23.36 | 9.49 | 17 | 105826 | 757 | 46579462 |
Pulmonary arterial hypertension | 23.30 | 9.49 | 15 | 105828 | 25913 | 46554306 |
Diaphragmatic rupture | 23.25 | 9.49 | 11 | 105832 | 215 | 46580004 |
Product quality issue | 23.15 | 9.49 | 28 | 105815 | 35620 | 46544599 |
Femur fracture | 23.05 | 9.49 | 30 | 105813 | 36967 | 46543252 |
Oliguria | 22.97 | 9.49 | 57 | 105786 | 8702 | 46571517 |
Hypercreatininaemia | 22.40 | 9.49 | 13 | 105830 | 391 | 46579828 |
Peripheral swelling | 22.21 | 9.49 | 240 | 105603 | 157831 | 46422388 |
Tendon necrosis | 22.00 | 9.49 | 5 | 105838 | 5 | 46580214 |
Meningitis candida | 21.98 | 9.49 | 7 | 105836 | 43 | 46580176 |
Fixed eruption | 21.68 | 9.49 | 17 | 105826 | 848 | 46579371 |
Acinetobacter infection | 21.58 | 9.49 | 21 | 105822 | 1401 | 46578818 |
Bone marrow granuloma | 21.57 | 9.49 | 6 | 105837 | 21 | 46580198 |
Gastroenteritis staphylococcal | 21.56 | 9.49 | 8 | 105835 | 82 | 46580137 |
Diarrhoea | 21.55 | 9.49 | 1508 | 104335 | 558094 | 46022125 |
Activated partial thromboplastin time prolonged | 21.52 | 9.49 | 48 | 105795 | 6841 | 46573378 |
Product substitution issue | 21.51 | 9.49 | 4 | 105839 | 15027 | 46565192 |
Clostridium test positive | 21.49 | 9.49 | 24 | 105819 | 1880 | 46578339 |
Septic shock | 21.41 | 9.49 | 213 | 105630 | 57680 | 46522539 |
Dermatitis bullous | 21.39 | 9.49 | 51 | 105792 | 7592 | 46572627 |
Confabulation | 21.39 | 9.49 | 11 | 105832 | 259 | 46579960 |
Cholestatic liver injury | 21.32 | 9.49 | 25 | 105818 | 2065 | 46578154 |
Product use issue | 21.00 | 9.49 | 127 | 105716 | 94517 | 46485702 |
Diabetes mellitus | 20.93 | 9.49 | 52 | 105791 | 50013 | 46530206 |
Neutrophilic dermatosis | 20.81 | 9.49 | 8 | 105835 | 91 | 46580128 |
Multiple sclerosis relapse | 20.71 | 9.49 | 40 | 105803 | 42085 | 46538134 |
Potentiating drug interaction | 20.49 | 9.49 | 34 | 105809 | 3889 | 46576330 |
Neurotransmitter level altered | 20.37 | 9.49 | 4 | 105839 | 0 | 46580219 |
Renal vein compression | 20.37 | 9.49 | 4 | 105839 | 0 | 46580219 |
Tendon laxity | 20.37 | 9.49 | 4 | 105839 | 0 | 46580219 |
Hepatitis cholestatic | 20.27 | 9.49 | 46 | 105797 | 6631 | 46573588 |
Gallbladder disorder | 20.22 | 9.49 | 86 | 105757 | 17412 | 46562807 |
Rectal tube insertion | 19.99 | 9.49 | 5 | 105838 | 10 | 46580209 |
Polyneuropathy | 19.98 | 9.49 | 65 | 105778 | 11579 | 46568640 |
Bacteriuria | 19.96 | 9.49 | 15 | 105828 | 702 | 46579517 |
Product deposit | 19.79 | 9.49 | 9 | 105834 | 160 | 46580059 |
Enterovesical fistula | 19.71 | 9.49 | 13 | 105830 | 493 | 46579726 |
Feeding intolerance | 19.61 | 9.49 | 13 | 105830 | 497 | 46579722 |
Basal cell carcinoma | 19.61 | 9.49 | 11 | 105832 | 20476 | 46559743 |
Female genital tract fistula | 19.57 | 9.49 | 30 | 105813 | 3209 | 46577010 |
Hypoaesthesia | 19.45 | 9.49 | 378 | 105465 | 118491 | 46461728 |
Acute febrile neutrophilic dermatosis | 19.31 | 9.49 | 27 | 105816 | 2658 | 46577561 |
Rotator cuff syndrome | 19.28 | 9.49 | 64 | 105779 | 11519 | 46568700 |
Osteonecrosis | 19.20 | 9.49 | 18 | 105825 | 25726 | 46554493 |
Foetal exposure during pregnancy | 19.08 | 9.49 | 25 | 105818 | 30722 | 46549497 |
Dysuria | 18.98 | 9.49 | 118 | 105725 | 27715 | 46552504 |
Photosensitivity reaction | 18.96 | 9.49 | 68 | 105775 | 12724 | 46567495 |
Cholecystitis acute | 18.67 | 9.49 | 48 | 105795 | 7490 | 46572729 |
Head injury | 18.64 | 9.49 | 17 | 105826 | 24619 | 46555600 |
Vanishing bile duct syndrome | 18.54 | 9.49 | 14 | 105829 | 660 | 46579559 |
Hepatic enzyme increased | 18.54 | 9.49 | 109 | 105734 | 81678 | 46498541 |
Respiratory arrest | 18.53 | 9.49 | 30 | 105813 | 33786 | 46546433 |
Nervous system disorder | 18.43 | 9.49 | 79 | 105764 | 16050 | 46564169 |
Tonsillar haemorrhage | 18.31 | 9.49 | 9 | 105834 | 192 | 46580027 |
Cholelithiasis | 18.23 | 9.49 | 150 | 105693 | 38531 | 46541688 |
Product administration error | 18.22 | 9.49 | 11 | 105832 | 19670 | 46560549 |
Roseola | 18.13 | 9.49 | 4 | 105839 | 3 | 46580216 |
Skin oedema | 18.13 | 9.49 | 15 | 105828 | 808 | 46579411 |
Bradycardia | 18.04 | 9.49 | 83 | 105760 | 66215 | 46514004 |
Infrequent bowel movements | 18.02 | 9.49 | 17 | 105826 | 1091 | 46579128 |
Nephropathy toxic | 17.98 | 9.49 | 47 | 105796 | 7407 | 46572812 |
Vulvovaginal swelling | 17.96 | 9.49 | 12 | 105831 | 465 | 46579754 |
Long QT syndrome | 17.87 | 9.49 | 28 | 105815 | 3052 | 46577167 |
Herpes zoster | 17.86 | 9.49 | 86 | 105757 | 67786 | 46512433 |
Gastrointestinal infection | 17.73 | 9.49 | 45 | 105798 | 6965 | 46573254 |
Hypotony of eye | 17.71 | 9.49 | 8 | 105835 | 140 | 46580079 |
Crohn's disease | 17.69 | 9.49 | 44 | 105799 | 6727 | 46573492 |
Sensory processing disorder | 17.60 | 9.49 | 4 | 105839 | 4 | 46580215 |
Faecal volume decreased | 17.55 | 9.49 | 8 | 105835 | 143 | 46580076 |
Rectal abscess | 17.53 | 9.49 | 16 | 105827 | 984 | 46579235 |
Poisoning | 17.49 | 9.49 | 5 | 105838 | 13989 | 46566230 |
Myopathy | 17.48 | 9.49 | 52 | 105791 | 8829 | 46571390 |
Bronchitis | 17.36 | 9.49 | 155 | 105688 | 105824 | 46474395 |
Sepsis | 17.27 | 9.49 | 417 | 105426 | 135597 | 46444622 |
Staphylococcal scalded skin syndrome | 17.21 | 9.49 | 8 | 105835 | 150 | 46580069 |
Skin injury | 17.11 | 9.49 | 19 | 105824 | 1479 | 46578740 |
Leukocytosis | 17.10 | 9.49 | 101 | 105742 | 23297 | 46556922 |
Hepatitis infectious mononucleosis | 17.04 | 9.49 | 7 | 105836 | 96 | 46580123 |
Pancytopenia | 16.93 | 9.49 | 279 | 105564 | 84779 | 46495440 |
Cerebrovascular accident | 16.89 | 9.49 | 147 | 105696 | 100892 | 46479327 |
Intentional self-injury | 16.76 | 9.49 | 18 | 105825 | 24148 | 46556071 |
Exercise tolerance decreased | 16.73 | 9.49 | 34 | 105809 | 4543 | 46575676 |
Seroconversion test positive | 16.72 | 9.49 | 5 | 105838 | 24 | 46580195 |
Phlebitis | 16.64 | 9.49 | 40 | 105803 | 5986 | 46574233 |
Abscess | 16.63 | 9.49 | 69 | 105774 | 13820 | 46566399 |
Disease progression | 16.55 | 9.49 | 130 | 105713 | 91170 | 46489049 |
Abdominal pain lower | 16.50 | 9.49 | 93 | 105750 | 21088 | 46559131 |
Infective aneurysm | 16.45 | 9.49 | 11 | 105832 | 427 | 46579792 |
Blister | 16.40 | 9.49 | 164 | 105679 | 44467 | 46535752 |
Cardiac failure | 16.34 | 9.49 | 110 | 105733 | 79838 | 46500381 |
Skin candida | 16.28 | 9.49 | 14 | 105829 | 796 | 46579423 |
Rash | 16.26 | 9.49 | 975 | 104868 | 355537 | 46224682 |
Anhedonia | 16.23 | 9.49 | 56 | 105787 | 10279 | 46569940 |
Vulvovaginal burning sensation | 16.23 | 9.49 | 19 | 105824 | 1567 | 46578652 |
Hallucination | 16.22 | 9.49 | 179 | 105664 | 49772 | 46530447 |
Pulmonary hypertension | 16.15 | 9.49 | 36 | 105807 | 35957 | 46544262 |
Foreign body aspiration | 16.13 | 9.49 | 8 | 105835 | 174 | 46580045 |
Road traffic accident | 16.04 | 9.49 | 18 | 105825 | 23673 | 46556546 |
Acute myocardial infarction | 15.96 | 9.49 | 30 | 105813 | 31894 | 46548325 |
Injection site hyperaesthesia | 15.94 | 9.49 | 5 | 105838 | 29 | 46580190 |
Recall phenomenon | 15.89 | 9.49 | 12 | 105831 | 566 | 46579653 |
Oesophageal spasm | 15.82 | 9.49 | 21 | 105822 | 1968 | 46578251 |
Blood glucose increased | 15.78 | 9.49 | 97 | 105746 | 71916 | 46508303 |
Burnout syndrome | 15.53 | 9.49 | 8 | 105835 | 189 | 46580030 |
Toxic encephalopathy | 15.51 | 9.49 | 35 | 105808 | 5027 | 46575192 |
Arthritis | 15.49 | 9.49 | 107 | 105736 | 77209 | 46503010 |
Cystic fibrosis | 15.43 | 9.49 | 29 | 105814 | 3659 | 46576560 |
Collagen disorder | 15.42 | 9.49 | 8 | 105835 | 192 | 46580027 |
May-Thurner syndrome | 15.39 | 9.49 | 5 | 105838 | 33 | 46580186 |
Hot flush | 15.38 | 9.49 | 49 | 105794 | 43468 | 46536751 |
Cardiac arrest | 15.34 | 9.49 | 131 | 105712 | 90268 | 46489951 |
Haemorrhagic vasculitis | 15.32 | 9.49 | 6 | 105837 | 72 | 46580147 |
Influenza | 15.31 | 9.49 | 129 | 105714 | 89141 | 46491078 |
Frequent bowel movements | 15.31 | 9.49 | 63 | 105780 | 12569 | 46567650 |
Clitoral engorgement | 15.28 | 9.49 | 3 | 105840 | 0 | 46580219 |
Somatic dysfunction | 15.28 | 9.49 | 3 | 105840 | 0 | 46580219 |
Injection site joint erythema | 15.28 | 9.49 | 3 | 105840 | 0 | 46580219 |
Dyspnoea | 15.27 | 9.49 | 986 | 104857 | 514562 | 46065657 |
Nerve degeneration | 15.25 | 9.49 | 6 | 105837 | 73 | 46580146 |
Renal injury | 15.25 | 9.49 | 52 | 105791 | 9489 | 46570730 |
Toxic neuropathy | 15.24 | 9.49 | 10 | 105833 | 376 | 46579843 |
Clostridium colitis | 15.17 | 9.49 | 20 | 105823 | 1862 | 46578357 |
Purple glove syndrome | 15.16 | 9.49 | 8 | 105835 | 199 | 46580020 |
Cholecystitis | 15.12 | 9.49 | 69 | 105774 | 14397 | 46565822 |
Diabetic macroangiopathy | 14.88 | 9.49 | 7 | 105836 | 135 | 46580084 |
Tongue geographic | 14.82 | 9.49 | 6 | 105837 | 79 | 46580140 |
Haematuria | 14.79 | 9.49 | 108 | 105735 | 26750 | 46553469 |
Limb immobilisation | 14.79 | 9.49 | 5 | 105838 | 38 | 46580181 |
Arrhythmia | 14.78 | 9.49 | 132 | 105711 | 34709 | 46545510 |
Chronic fatigue syndrome | 14.74 | 9.49 | 15 | 105828 | 1056 | 46579163 |
Oxygen saturation decreased | 14.72 | 9.49 | 94 | 105749 | 69070 | 46511149 |
Mucosal inflammation | 14.70 | 9.49 | 144 | 105699 | 38832 | 46541387 |
Myoclonus | 14.67 | 9.49 | 68 | 105775 | 14284 | 46565935 |
Dysaesthesia | 14.62 | 9.49 | 26 | 105817 | 3145 | 46577074 |
Injection site streaking | 14.56 | 9.49 | 5 | 105838 | 40 | 46580179 |
Post viral fatigue syndrome | 14.56 | 9.49 | 7 | 105836 | 142 | 46580077 |
Norovirus test positive | 14.51 | 9.49 | 7 | 105836 | 143 | 46580076 |
Ballismus | 14.49 | 9.49 | 6 | 105837 | 84 | 46580135 |
Electrocardiogram QT prolonged | 14.47 | 9.49 | 179 | 105664 | 51146 | 46529073 |
Abnormal palmar/plantar creases | 14.46 | 9.49 | 5 | 105838 | 41 | 46580178 |
Biopsy colon abnormal | 14.46 | 9.49 | 5 | 105838 | 41 | 46580178 |
Vulvovaginal pain | 14.42 | 9.49 | 21 | 105822 | 2146 | 46578073 |
Small fibre neuropathy | 14.38 | 9.49 | 7 | 105836 | 146 | 46580073 |
Fasciitis | 14.36 | 9.49 | 11 | 105832 | 530 | 46579689 |
Bacteraemia | 14.36 | 9.49 | 67 | 105776 | 14112 | 46566107 |
Somnolence | 14.34 | 9.49 | 259 | 105584 | 156262 | 46423957 |
Haemolytic anaemia | 14.31 | 9.49 | 52 | 105791 | 9790 | 46570429 |
Neoplasm progression | 14.31 | 9.49 | 24 | 105819 | 26659 | 46553560 |
Crystal nephropathy | 14.08 | 9.49 | 13 | 105830 | 812 | 46579407 |
Malignant melanoma | 14.07 | 9.49 | 3 | 105840 | 10231 | 46569988 |
Neutropenic infection | 13.99 | 9.49 | 15 | 105828 | 1123 | 46579096 |
Deficiency of bile secretion | 13.97 | 9.49 | 4 | 105839 | 16 | 46580203 |
C-reactive protein decreased | 13.94 | 9.49 | 12 | 105831 | 683 | 46579536 |
Blood creatinine increased | 13.89 | 9.49 | 247 | 105596 | 76156 | 46504063 |
Infected fistula | 13.88 | 9.49 | 6 | 105837 | 94 | 46580125 |
Escherichia urinary tract infection | 13.73 | 9.49 | 53 | 105790 | 10270 | 46569949 |
Depersonalisation/derealisation disorder | 13.64 | 9.49 | 14 | 105829 | 996 | 46579223 |
Red blood cell sedimentation rate abnormal | 13.54 | 9.49 | 7 | 105836 | 13642 | 46566577 |
Hypertensive crisis | 13.48 | 9.49 | 7 | 105836 | 13608 | 46566611 |
Overdose | 13.46 | 9.49 | 157 | 105686 | 101822 | 46478397 |
Hyperpathia | 13.41 | 9.49 | 4 | 105839 | 19 | 46580200 |
Vitreous floaters | 13.41 | 9.49 | 33 | 105810 | 5012 | 46575207 |
Plantar fasciitis | 13.40 | 9.49 | 23 | 105820 | 2705 | 46577514 |
Tuberculosis gastrointestinal | 13.37 | 9.49 | 9 | 105834 | 353 | 46579866 |
Iatrogenic injury | 13.27 | 9.49 | 13 | 105830 | 874 | 46579345 |
Walking disability | 13.26 | 9.49 | 16 | 105827 | 1362 | 46578857 |
Sensory disturbance | 13.19 | 9.49 | 59 | 105784 | 12208 | 46568011 |
Skin test positive | 13.18 | 9.49 | 12 | 105831 | 736 | 46579483 |
Candida infection | 13.16 | 9.49 | 91 | 105752 | 22149 | 46558070 |
Flushing | 13.15 | 9.49 | 89 | 105754 | 64525 | 46515694 |
Haematoma | 13.14 | 9.49 | 120 | 105723 | 31752 | 46548467 |
Restlessness | 13.13 | 9.49 | 101 | 105742 | 25423 | 46554796 |
Underdose | 13.09 | 9.49 | 15 | 105828 | 19543 | 46560676 |
Peripheral nerve injury | 13.04 | 9.49 | 9 | 105834 | 368 | 46579851 |
Condition aggravated | 13.02 | 9.49 | 440 | 105403 | 244612 | 46335607 |
Incorrect dose administered | 13.01 | 9.49 | 56 | 105787 | 45494 | 46534725 |
Abdominal pain upper | 12.99 | 9.49 | 426 | 105417 | 144879 | 46435340 |
Muscle tightness | 12.97 | 9.49 | 52 | 105791 | 10253 | 46569966 |
Neuralgia | 12.95 | 9.49 | 88 | 105755 | 21295 | 46558924 |
Deafness bilateral | 12.86 | 9.49 | 15 | 105828 | 1232 | 46578987 |
Conjunctival hyperaemia | 12.84 | 9.49 | 19 | 105824 | 1970 | 46578249 |
Factor XIII Inhibition | 12.78 | 9.49 | 4 | 105839 | 23 | 46580196 |
Leukocyturia | 12.55 | 9.49 | 13 | 105830 | 935 | 46579284 |
Eczema asteatotic | 12.52 | 9.49 | 8 | 105835 | 287 | 46579932 |
Plasma cell myeloma | 12.51 | 9.49 | 55 | 105788 | 44423 | 46535796 |
Burning mouth syndrome | 12.40 | 9.49 | 9 | 105834 | 399 | 46579820 |
Metastases to kidney | 12.39 | 9.49 | 7 | 105836 | 200 | 46580019 |
Pneumonia aspiration | 12.31 | 9.49 | 34 | 105809 | 31571 | 46548648 |
Fatigue | 12.30 | 9.49 | 1201 | 104642 | 607496 | 45972723 |
Spinal fracture | 12.26 | 9.49 | 10 | 105833 | 15295 | 46564924 |
Eosinophilia | 12.19 | 9.49 | 80 | 105763 | 19137 | 46561082 |
Bulimia nervosa | 12.15 | 9.49 | 10 | 105833 | 535 | 46579684 |
Fluid retention | 12.12 | 9.49 | 67 | 105776 | 50979 | 46529240 |
Perineal abscess | 12.08 | 9.49 | 7 | 105836 | 210 | 46580009 |
Tenosynovitis | 12.05 | 9.49 | 41 | 105802 | 7474 | 46572745 |
Muscle strength abnormal | 11.99 | 9.49 | 3 | 105840 | 6 | 46580213 |
Staphylococcal sepsis | 11.99 | 9.49 | 41 | 105802 | 7491 | 46572728 |
Kidney infection | 11.96 | 9.49 | 72 | 105771 | 16717 | 46563502 |
Type IV hypersensitivity reaction | 11.93 | 9.49 | 21 | 105822 | 2519 | 46577700 |
Gallbladder rupture | 11.92 | 9.49 | 9 | 105834 | 424 | 46579795 |
Fear of death | 11.91 | 9.49 | 13 | 105830 | 993 | 46579226 |
Sinusitis | 11.80 | 9.49 | 215 | 105628 | 129553 | 46450666 |
Drug withdrawal syndrome | 11.79 | 9.49 | 28 | 105815 | 27356 | 46552863 |
Epicondylitis | 11.76 | 9.49 | 17 | 105826 | 1725 | 46578494 |
Mast cell activation syndrome | 11.76 | 9.49 | 7 | 105836 | 221 | 46579998 |
Medical device site pain | 11.73 | 9.49 | 7 | 105836 | 222 | 46579997 |
Gallbladder injury | 11.69 | 9.49 | 15 | 105828 | 1359 | 46578860 |
Device malfunction | 11.66 | 9.49 | 8 | 105835 | 13366 | 46566853 |
Mitochondrial enzyme deficiency | 11.65 | 9.49 | 4 | 105839 | 32 | 46580187 |
Quadriparesis | 11.60 | 9.49 | 17 | 105826 | 1747 | 46578472 |
Mycobacterium chelonae infection | 11.60 | 9.49 | 9 | 105834 | 442 | 46579777 |
Hypotension | 11.57 | 9.49 | 421 | 105422 | 232168 | 46348051 |
Nervousness | 11.57 | 9.49 | 30 | 105813 | 28445 | 46551774 |
Sense of oppression | 11.56 | 9.49 | 13 | 105830 | 1026 | 46579193 |
Depressed level of consciousness | 11.53 | 9.49 | 62 | 105781 | 47507 | 46532712 |
Henoch-Schonlein purpura | 11.53 | 9.49 | 13 | 105830 | 1029 | 46579190 |
Toxic shock syndrome | 11.48 | 9.49 | 9 | 105834 | 449 | 46579770 |
Paraesthesia oral | 11.46 | 9.49 | 55 | 105788 | 11718 | 46568501 |
Vulvovaginal candidiasis | 11.46 | 9.49 | 21 | 105822 | 2600 | 46577619 |
Mineral metabolism disorder | 11.40 | 9.49 | 3 | 105840 | 8 | 46580211 |
Ligament rupture | 11.39 | 9.49 | 21 | 105822 | 2612 | 46577607 |
Urethral pain | 11.34 | 9.49 | 6 | 105837 | 150 | 46580069 |
Nasal polyps | 11.34 | 9.49 | 19 | 105824 | 2191 | 46578028 |
Intrauterine infection | 11.20 | 9.49 | 5 | 105838 | 85 | 46580134 |
Diarrhoea haemorrhagic | 11.20 | 9.49 | 40 | 105803 | 7469 | 46572750 |
Transient ischaemic attack | 11.18 | 9.49 | 41 | 105802 | 34862 | 46545357 |
Blood disorder | 11.12 | 9.49 | 33 | 105810 | 5594 | 46574625 |
Extremity necrosis | 11.12 | 9.49 | 16 | 105827 | 1617 | 46578602 |
Hallucinations, mixed | 11.11 | 9.49 | 26 | 105817 | 3823 | 46576396 |
Myocardial infarction | 11.07 | 9.49 | 155 | 105688 | 97373 | 46482846 |
Extraocular muscle paresis | 10.99 | 9.49 | 6 | 105837 | 160 | 46580059 |
Thyroxine free decreased | 10.92 | 9.49 | 9 | 105834 | 482 | 46579737 |
Muscle rupture | 10.92 | 9.49 | 18 | 105825 | 2047 | 46578172 |
Vein discolouration | 10.92 | 9.49 | 6 | 105837 | 162 | 46580057 |
Complex regional pain syndrome | 10.92 | 9.49 | 18 | 105825 | 2048 | 46578171 |
Cytokine release syndrome | 10.91 | 9.49 | 35 | 105808 | 6188 | 46574031 |
Grip strength decreased | 10.90 | 9.49 | 3 | 105840 | 8603 | 46571616 |
Urticaria | 10.89 | 9.49 | 347 | 105496 | 117545 | 46462674 |
Visual impairment | 10.87 | 9.49 | 212 | 105631 | 66477 | 46513742 |
Ureteric injury | 10.87 | 9.49 | 4 | 105839 | 40 | 46580179 |
Myositis | 10.86 | 9.49 | 41 | 105802 | 7863 | 46572356 |
Acid base balance abnormal | 10.67 | 9.49 | 7 | 105836 | 263 | 46579956 |
Abdominal tenderness | 10.65 | 9.49 | 38 | 105805 | 7090 | 46573129 |
Injection site urticaria | 10.65 | 9.49 | 7 | 105836 | 11960 | 46568259 |
Fracture | 10.63 | 9.49 | 13 | 105830 | 16458 | 46563761 |
Staphylococcal infection | 10.63 | 9.49 | 126 | 105717 | 35645 | 46544574 |
Gastroenteritis clostridial | 10.61 | 9.49 | 9 | 105834 | 502 | 46579717 |
Peritoneal adhesions | 10.60 | 9.49 | 7 | 105836 | 266 | 46579953 |
Dermatitis exfoliative generalised | 10.56 | 9.49 | 22 | 105821 | 2991 | 46577228 |
Plasmapheresis | 10.53 | 9.49 | 7 | 105836 | 269 | 46579950 |
Injection site thrombosis | 10.51 | 9.49 | 5 | 105838 | 99 | 46580120 |
Hormone level abnormal | 10.46 | 9.49 | 18 | 105825 | 2120 | 46578099 |
Skin burning sensation | 10.44 | 9.49 | 50 | 105793 | 10642 | 46569577 |
Cystitis interstitial | 10.41 | 9.49 | 14 | 105829 | 1328 | 46578891 |
Abscess intestinal | 10.38 | 9.49 | 14 | 105829 | 1332 | 46578887 |
Exfoliative rash | 10.36 | 9.49 | 20 | 105823 | 2575 | 46577644 |
Paraneoplastic syndrome | 10.27 | 9.49 | 9 | 105834 | 525 | 46579694 |
Helicobacter infection | 10.26 | 9.49 | 7 | 105836 | 11729 | 46568490 |
Hyperkalaemia | 10.25 | 9.49 | 70 | 105773 | 50639 | 46529580 |
Scar excision | 10.22 | 9.49 | 4 | 105839 | 48 | 46580171 |
Rash erythematous | 10.21 | 9.49 | 121 | 105722 | 34229 | 46545990 |
Thyroxine increased | 10.18 | 9.49 | 9 | 105834 | 531 | 46579688 |
Single functional kidney | 10.16 | 9.49 | 5 | 105838 | 107 | 46580112 |
Infusion site reaction | 10.15 | 9.49 | 16 | 105827 | 1753 | 46578466 |
Device related infection | 10.13 | 9.49 | 82 | 105761 | 20959 | 46559260 |
Chronic graft versus host disease in eye | 10.10 | 9.49 | 3 | 105840 | 14 | 46580205 |
Right ventricular failure | 10.07 | 9.49 | 13 | 105830 | 16080 | 46564139 |
Oophoritis | 10.07 | 9.49 | 4 | 105839 | 50 | 46580169 |
Immune effector cell-associated neurotoxicity syndrome | 10.07 | 9.49 | 10 | 105833 | 684 | 46579535 |
Clostridium bacteraemia | 10.03 | 9.49 | 6 | 105837 | 191 | 46580028 |
Osteonecrosis of jaw | 10.00 | 9.49 | 42 | 105801 | 34360 | 46545859 |
Enterocutaneous fistula | 9.97 | 9.49 | 13 | 105830 | 1197 | 46579022 |
Face oedema | 9.97 | 9.49 | 76 | 105767 | 19077 | 46561142 |
Intestinal dilatation | 9.91 | 9.49 | 15 | 105828 | 1587 | 46578632 |
Glaucoma | 9.82 | 9.49 | 13 | 105830 | 15908 | 46564311 |
Thrombotic thrombocytopenic purpura | 9.79 | 9.49 | 25 | 105818 | 3885 | 46576334 |
External ear inflammation | 9.77 | 9.49 | 3 | 105840 | 16 | 46580203 |
Ligament disorder | 9.73 | 9.49 | 8 | 105835 | 427 | 46579792 |
Rectal tenesmus | 9.73 | 9.49 | 8 | 105835 | 427 | 46579792 |
Vulvovaginal inflammation | 9.73 | 9.49 | 9 | 105834 | 563 | 46579656 |
Refractory anaemia with an excess of blasts | 9.73 | 9.49 | 8 | 105835 | 427 | 46579792 |
Pre-eclampsia | 9.73 | 9.49 | 3 | 105840 | 7991 | 46572228 |
Injection site rash | 9.67 | 9.49 | 13 | 105830 | 15800 | 46564419 |
Faeces soft | 9.64 | 9.49 | 23 | 105820 | 3425 | 46576794 |
Nephrolithiasis | 9.63 | 9.49 | 116 | 105727 | 32935 | 46547284 |
Loss of consciousness | 9.63 | 9.49 | 180 | 105663 | 108058 | 46472161 |
Mucosal hyperaemia | 9.62 | 9.49 | 3 | 105840 | 17 | 46580202 |
Connective tissue inflammation | 9.60 | 9.49 | 4 | 105839 | 57 | 46580162 |
Product complaint | 9.58 | 9.49 | 8 | 105835 | 12093 | 46568126 |
Human ehrlichiosis | 9.58 | 9.49 | 6 | 105837 | 208 | 46580011 |
Cholesterosis | 9.57 | 9.49 | 8 | 105835 | 437 | 46579782 |
Thrombocytosis | 9.57 | 9.49 | 29 | 105814 | 4973 | 46575246 |
Purpura fulminans | 9.53 | 9.49 | 4 | 105839 | 58 | 46580161 |
Abscess fungal | 9.53 | 9.49 | 4 | 105839 | 58 | 46580161 |
Concomitant disease aggravated | 9.52 | 9.49 | 3 | 105840 | 7879 | 46572340 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Tendon pain | 637.09 | 9.91 | 244 | 80233 | 2283 | 29869718 |
Tendonitis | 592.03 | 9.91 | 330 | 80147 | 7706 | 29864295 |
Tendon rupture | 429.39 | 9.91 | 256 | 80221 | 6808 | 29865193 |
Tendon disorder | 257.36 | 9.91 | 125 | 80352 | 2171 | 29869830 |
Death | 202.20 | 9.91 | 411 | 80066 | 356872 | 29515129 |
Pathogen resistance | 187.76 | 9.91 | 166 | 80311 | 8244 | 29863757 |
Tendon discomfort | 161.31 | 9.91 | 49 | 80428 | 204 | 29871797 |
Drug abuse | 152.76 | 9.91 | 20 | 80457 | 82052 | 29789949 |
Completed suicide | 144.24 | 9.91 | 44 | 80433 | 99448 | 29772553 |
Toxic epidermal necrolysis | 143.03 | 9.91 | 207 | 80270 | 17733 | 29854268 |
Drug hypersensitivity | 127.01 | 9.91 | 439 | 80038 | 68080 | 29803921 |
Drug interaction | 126.61 | 9.91 | 943 | 79534 | 198625 | 29673376 |
Clostridium difficile colitis | 113.16 | 9.91 | 155 | 80322 | 12613 | 29859388 |
Myocardial infarction | 111.44 | 9.91 | 104 | 80373 | 125521 | 29746480 |
Drug resistance | 102.91 | 9.91 | 190 | 80287 | 19943 | 29852058 |
Joint noise | 101.80 | 9.91 | 43 | 80434 | 529 | 29871472 |
Tinnitus | 84.96 | 9.91 | 154 | 80323 | 15934 | 29856067 |
Drug reaction with eosinophilia and systemic symptoms | 78.60 | 9.91 | 210 | 80267 | 28278 | 29843723 |
Septic shock | 78.59 | 9.91 | 359 | 80118 | 63248 | 29808753 |
Intentional overdose | 72.77 | 9.91 | 12 | 80465 | 41469 | 29830532 |
Tubulointerstitial nephritis | 69.97 | 9.91 | 151 | 80326 | 17740 | 29854261 |
Neuralgia | 69.57 | 9.91 | 111 | 80366 | 10355 | 29861646 |
Product dose omission issue | 68.86 | 9.91 | 87 | 80390 | 91544 | 29780457 |
Overdose | 68.82 | 9.91 | 75 | 80402 | 84262 | 29787739 |
Fall | 68.80 | 9.91 | 254 | 80223 | 181618 | 29690383 |
Cerebrovascular accident | 68.37 | 9.91 | 74 | 80403 | 83403 | 29788598 |
Paraesthesia | 68.12 | 9.91 | 308 | 80169 | 54019 | 29817982 |
Myalgia | 67.73 | 9.91 | 394 | 80083 | 76273 | 29795728 |
Toxicity to various agents | 62.80 | 9.91 | 254 | 80223 | 176929 | 29695072 |
Urinary tract infection | 62.77 | 9.91 | 375 | 80102 | 73284 | 29798717 |
Hyperacusis | 61.98 | 9.91 | 31 | 80446 | 575 | 29871426 |
Panic attack | 61.77 | 9.91 | 95 | 80382 | 8586 | 29863415 |
Choroiditis | 60.67 | 9.91 | 34 | 80443 | 801 | 29871200 |
Torsade de pointes | 60.28 | 9.91 | 85 | 80392 | 7105 | 29864896 |
Pseudomonas infection | 58.76 | 9.91 | 103 | 80374 | 10379 | 29861622 |
Stevens-Johnson syndrome | 58.44 | 9.91 | 139 | 80338 | 17417 | 29854584 |
Prostatitis | 58.40 | 9.91 | 69 | 80408 | 4838 | 29867163 |
Arthralgia | 57.78 | 9.91 | 588 | 79889 | 135203 | 29736798 |
Foetal exposure during pregnancy | 57.72 | 9.91 | 14 | 80463 | 36857 | 29835144 |
Pruritus genital | 57.06 | 9.91 | 27 | 80450 | 441 | 29871560 |
Pseudomembranous colitis | 55 | 9.91 | 52 | 80425 | 2816 | 29869185 |
Muscle twitching | 54.90 | 9.91 | 87 | 80390 | 8068 | 29863933 |
Dysbiosis | 54.51 | 9.91 | 25 | 80452 | 379 | 29871622 |
Rheumatoid arthritis | 53.19 | 9.91 | 22 | 80455 | 41175 | 29830826 |
Eye pain | 48.99 | 9.91 | 102 | 80375 | 11687 | 29860314 |
Clostridium difficile infection | 48.31 | 9.91 | 121 | 80356 | 15662 | 29856339 |
Solar lentigo | 45.75 | 9.91 | 21 | 80456 | 319 | 29871682 |
Muscle rupture | 45.61 | 9.91 | 41 | 80436 | 2080 | 29869921 |
Cardiac failure congestive | 45.00 | 9.91 | 100 | 80377 | 84307 | 29787694 |
Dysplastic naevus | 44.60 | 9.91 | 21 | 80456 | 339 | 29871662 |
Burning sensation | 43.98 | 9.91 | 120 | 80357 | 16354 | 29855647 |
Acute generalised exanthematous pustulosis | 43.76 | 9.91 | 67 | 80410 | 6031 | 29865970 |
Fistula | 43.60 | 9.91 | 61 | 80416 | 5061 | 29866940 |
Abdominal abscess | 42.29 | 9.91 | 53 | 80424 | 3951 | 29868050 |
Pyrexia | 42.26 | 9.91 | 1062 | 79415 | 293427 | 29578574 |
Endophthalmitis | 41.53 | 9.91 | 49 | 80428 | 3431 | 29868570 |
Urosepsis | 41.30 | 9.91 | 90 | 80387 | 10642 | 29861359 |
Wrong technique in product usage process | 41.26 | 9.91 | 16 | 80461 | 31139 | 29840862 |
Photodermatosis | 40.83 | 9.91 | 21 | 80456 | 414 | 29871587 |
Psoriasis | 40.28 | 9.91 | 33 | 80444 | 42473 | 29829528 |
Factor V inhibition | 39.80 | 9.91 | 16 | 80461 | 172 | 29871829 |
Acute myocardial infarction | 38.98 | 9.91 | 51 | 80426 | 52888 | 29819113 |
Intentional product misuse | 38.01 | 9.91 | 23 | 80454 | 34644 | 29837357 |
Night sweats | 37.96 | 9.91 | 105 | 80372 | 14423 | 29857578 |
Impaired work ability | 37.71 | 9.91 | 60 | 80417 | 5583 | 29866418 |
Orchitis | 37.19 | 9.91 | 32 | 80445 | 1531 | 29870470 |
Tendon injury | 37.11 | 9.91 | 25 | 80452 | 825 | 29871176 |
Linear IgA disease | 36.51 | 9.91 | 32 | 80445 | 1570 | 29870431 |
Crohn's disease | 35.82 | 9.91 | 51 | 80426 | 4301 | 29867700 |
Multiple organ dysfunction syndrome | 35.64 | 9.91 | 292 | 80185 | 63195 | 29808806 |
Diastasis recti abdominis | 35.15 | 9.91 | 9 | 80468 | 16 | 29871985 |
Musculoskeletal injury | 33.89 | 9.91 | 13 | 80464 | 122 | 29871879 |
Aortic valve prolapse | 33.37 | 9.91 | 8 | 80469 | 9 | 29871992 |
Clostridium test positive | 33.32 | 9.91 | 34 | 80443 | 2022 | 29869979 |
Aeromonas infection | 33.29 | 9.91 | 16 | 80461 | 271 | 29871730 |
Plantar fasciitis | 32.94 | 9.91 | 24 | 80453 | 900 | 29871101 |
Suicide attempt | 32.93 | 9.91 | 30 | 80447 | 36667 | 29835334 |
Blood glucose increased | 32.70 | 9.91 | 73 | 80404 | 61457 | 29810544 |
Ependymoma | 32.64 | 9.91 | 11 | 80466 | 68 | 29871933 |
Yellow fever | 31.97 | 9.91 | 7 | 80470 | 3 | 29871998 |
Febrile neutropenia | 31.97 | 9.91 | 432 | 80045 | 106261 | 29765740 |
Candida infection | 31.58 | 9.91 | 102 | 80375 | 15260 | 29856741 |
Escherichia infection | 30.91 | 9.91 | 59 | 80418 | 6346 | 29865655 |
Anuria | 30.44 | 9.91 | 78 | 80399 | 10238 | 29861763 |
Pouchitis | 30.32 | 9.91 | 20 | 80457 | 637 | 29871364 |
Renal tubular necrosis | 30.22 | 9.91 | 100 | 80377 | 15151 | 29856850 |
Acute kidney injury | 30.13 | 9.91 | 955 | 79522 | 272887 | 29599114 |
Fixed eruption | 29.73 | 9.91 | 25 | 80452 | 1159 | 29870842 |
Undersensing | 29.62 | 9.91 | 7 | 80470 | 7 | 29871994 |
Chest pain | 29.46 | 9.91 | 190 | 80287 | 117437 | 29754564 |
Hypertension | 29.40 | 9.91 | 198 | 80279 | 121156 | 29750845 |
Injection site pain | 29.38 | 9.91 | 23 | 80454 | 30287 | 29841714 |
Aspergillus infection | 28.87 | 9.91 | 76 | 80401 | 10138 | 29861863 |
Infective pulmonary exacerbation of cystic fibrosis | 28.66 | 9.91 | 68 | 80409 | 8504 | 29863497 |
Sphingomonas paucimobilis infection | 28.63 | 9.91 | 9 | 80468 | 43 | 29871958 |
Connective tissue disorder | 28.23 | 9.91 | 13 | 80464 | 199 | 29871802 |
Vitreous floaters | 28.16 | 9.91 | 39 | 80438 | 3205 | 29868796 |
Dyspnoea | 28.04 | 9.91 | 682 | 79795 | 332613 | 29539388 |
Neuropathy peripheral | 27.94 | 9.91 | 301 | 80176 | 70174 | 29801827 |
Hypnagogic hallucination | 27.87 | 9.91 | 8 | 80469 | 26 | 29871975 |
Asthma | 27.51 | 9.91 | 34 | 80443 | 36140 | 29835861 |
Ligament pain | 27.14 | 9.91 | 7 | 80470 | 13 | 29871988 |
Premature baby | 26.79 | 9.91 | 6 | 80471 | 16685 | 29855316 |
Rectal abscess | 26.57 | 9.91 | 21 | 80456 | 891 | 29871110 |
Penis injury | 26.34 | 9.91 | 13 | 80464 | 234 | 29871767 |
Weight increased | 26.10 | 9.91 | 108 | 80369 | 74805 | 29797196 |
Cutaneous vasculitis | 26.03 | 9.91 | 36 | 80441 | 2955 | 29869046 |
Pelvic abscess | 25.77 | 9.91 | 21 | 80456 | 931 | 29871070 |
Abscess intestinal | 25.74 | 9.91 | 25 | 80452 | 1400 | 29870601 |
Coronary artery disease | 25.59 | 9.91 | 60 | 80417 | 49652 | 29822349 |
Palpitations | 25.49 | 9.91 | 166 | 80311 | 33407 | 29838594 |
Walking aid user | 25.42 | 9.91 | 25 | 80452 | 1422 | 29870579 |
Enterococcal infection | 25.11 | 9.91 | 63 | 80414 | 8161 | 29863840 |
Anal abscess | 24.84 | 9.91 | 47 | 80430 | 5022 | 29866979 |
Chest injury | 24.77 | 9.91 | 24 | 80453 | 1340 | 29870661 |
Yellow fever vaccine-associated viscerotropic disease | 24.61 | 9.91 | 5 | 80472 | 0 | 29872001 |
Sensory processing disorder | 24.61 | 9.91 | 5 | 80472 | 0 | 29872001 |
Abscess | 24.53 | 9.91 | 71 | 80406 | 10007 | 29861994 |
Anal fissure | 24.22 | 9.91 | 31 | 80446 | 2360 | 29869641 |
Anxiety | 24.14 | 9.91 | 357 | 80120 | 89514 | 29782487 |
Pulmonary embolism | 24.01 | 9.91 | 118 | 80359 | 78017 | 29793984 |
Cardiac failure | 23.93 | 9.91 | 129 | 80348 | 83289 | 29788712 |
Chronic fatigue syndrome | 23.71 | 9.91 | 13 | 80464 | 293 | 29871708 |
Trichosporon infection | 23.36 | 9.91 | 17 | 80460 | 636 | 29871365 |
Photosensitivity reaction | 23.31 | 9.91 | 68 | 80409 | 9626 | 29862375 |
Musculoskeletal discomfort | 23.30 | 9.91 | 52 | 80425 | 6248 | 29865753 |
Intraocular pressure increased | 23.29 | 9.91 | 46 | 80431 | 5074 | 29866927 |
Bradycardia | 23.11 | 9.91 | 94 | 80383 | 65432 | 29806569 |
Geotrichum infection | 23.10 | 9.91 | 15 | 80462 | 465 | 29871536 |
Corneal deposits | 22.96 | 9.91 | 11 | 80466 | 185 | 29871816 |
Impaired quality of life | 22.60 | 9.91 | 24 | 80453 | 1495 | 29870506 |
Therapeutic product effect incomplete | 22.52 | 9.91 | 35 | 80442 | 33799 | 29838202 |
Urinary tract obstruction | 22.50 | 9.91 | 36 | 80441 | 3365 | 29868636 |
Cystitis | 22.35 | 9.91 | 61 | 80416 | 8313 | 29863688 |
Cardio-respiratory arrest | 22.29 | 9.91 | 79 | 80398 | 57227 | 29814774 |
Oxidative stress | 22.17 | 9.91 | 7 | 80470 | 34 | 29871967 |
Condition aggravated | 22.04 | 9.91 | 505 | 79972 | 137361 | 29734640 |
Myosclerosis | 22.04 | 9.91 | 9 | 80468 | 101 | 29871900 |
Penile haemorrhage | 22.03 | 9.91 | 16 | 80461 | 597 | 29871404 |
Phlebitis infective | 22.02 | 9.91 | 10 | 80467 | 148 | 29871853 |
Pain in extremity | 21.95 | 9.91 | 417 | 80060 | 109804 | 29762197 |
Blood pressure increased | 21.88 | 9.91 | 109 | 80368 | 71819 | 29800182 |
Nosocomial infection | 21.59 | 9.91 | 21 | 80456 | 1178 | 29870823 |
Diabetic ketoacidosis | 21.51 | 9.91 | 8 | 80469 | 15978 | 29856023 |
Ear pain | 21.49 | 9.91 | 41 | 80436 | 4409 | 29867592 |
Abdominal pain | 21.41 | 9.91 | 496 | 79981 | 135158 | 29736843 |
Intestinal stenosis | 21.38 | 9.91 | 26 | 80451 | 1879 | 29870122 |
Product quality issue | 21.22 | 9.91 | 12 | 80465 | 18762 | 29853239 |
Dermatitis bullous | 21.04 | 9.91 | 49 | 80428 | 6055 | 29865946 |
Gastrointestinal inflammation | 20.84 | 9.91 | 32 | 80445 | 2887 | 29869114 |
Clostridial infection | 20.81 | 9.91 | 36 | 80441 | 3589 | 29868412 |
Acinetobacter infection | 20.69 | 9.91 | 19 | 80458 | 991 | 29871010 |
Infective aneurysm | 20.57 | 9.91 | 13 | 80464 | 384 | 29871617 |
Subacute cutaneous lupus erythematosus | 20.57 | 9.91 | 16 | 80461 | 663 | 29871338 |
Ischaemic stroke | 20.51 | 9.91 | 9 | 80468 | 16266 | 29855735 |
Chronic obstructive pulmonary disease | 20.43 | 9.91 | 60 | 80417 | 46066 | 29825935 |
Otorrhoea | 20.39 | 9.91 | 14 | 80463 | 477 | 29871524 |
Diabetes mellitus | 20.39 | 9.91 | 52 | 80425 | 41813 | 29830188 |
Lumbosacral plexus injury | 20.35 | 9.91 | 6 | 80471 | 22 | 29871979 |
Painful respiration | 20.27 | 9.91 | 21 | 80456 | 1271 | 29870730 |
Hyphaema | 20.25 | 9.91 | 13 | 80464 | 395 | 29871606 |
Chronic gastrointestinal bleeding | 20.06 | 9.91 | 11 | 80466 | 248 | 29871753 |
Prolapse | 19.69 | 9.91 | 4 | 80473 | 0 | 29872001 |
Yellow fever vaccine-associated neurotropic disease | 19.69 | 9.91 | 4 | 80473 | 0 | 29872001 |
Posterior tibial tendon dysfunction | 19.69 | 9.91 | 4 | 80473 | 0 | 29872001 |
Sopor | 19.68 | 9.91 | 3 | 80474 | 10988 | 29861013 |
Anal fistula | 19.59 | 9.91 | 37 | 80440 | 3949 | 29868052 |
Enterocutaneous fistula | 19.51 | 9.91 | 16 | 80461 | 716 | 29871285 |
Megacolon | 19.22 | 9.91 | 23 | 80454 | 1634 | 29870367 |
Angina pectoris | 19.20 | 9.91 | 31 | 80446 | 29487 | 29842514 |
Cardiac disorder | 19.08 | 9.91 | 50 | 80427 | 39843 | 29832158 |
Food intolerance | 19.04 | 9.91 | 19 | 80458 | 1100 | 29870901 |
Neuroleptic malignant syndrome | 19.02 | 9.91 | 10 | 80467 | 16285 | 29855716 |
Weight bearing difficulty | 18.99 | 9.91 | 17 | 80460 | 858 | 29871143 |
Rash erythematous | 18.90 | 9.91 | 114 | 80363 | 22338 | 29849663 |
Septic embolus | 18.81 | 9.91 | 19 | 80458 | 1116 | 29870885 |
Hospitalisation | 18.67 | 9.91 | 59 | 80418 | 44260 | 29827741 |
Gluten sensitivity | 18.54 | 9.91 | 6 | 80471 | 32 | 29871969 |
Colitis | 18.51 | 9.91 | 144 | 80333 | 30676 | 29841325 |
Interstitial lung disease | 18.43 | 9.91 | 91 | 80386 | 60106 | 29811895 |
Myocardial haemorrhage | 18.39 | 9.91 | 6 | 80471 | 33 | 29871968 |
Thrombotic thrombocytopenic purpura | 18.35 | 9.91 | 33 | 80444 | 3392 | 29868609 |
Catatonia | 18.32 | 9.91 | 38 | 80439 | 4342 | 29867659 |
Intestinal fistula | 18.29 | 9.91 | 16 | 80461 | 783 | 29871218 |
Dyslexia | 18.29 | 9.91 | 9 | 80468 | 161 | 29871840 |
Defaecation urgency | 18.15 | 9.91 | 21 | 80456 | 1440 | 29870561 |
Anxiety disorder | 18.11 | 9.91 | 21 | 80456 | 1443 | 29870558 |
Henoch-Schonlein purpura | 17.96 | 9.91 | 21 | 80456 | 1456 | 29870545 |
Bacteraemia | 17.85 | 9.91 | 86 | 80391 | 15474 | 29856527 |
Intentional self-injury | 17.83 | 9.91 | 7 | 80470 | 13525 | 29858476 |
Cystic fibrosis | 17.77 | 9.91 | 26 | 80451 | 2248 | 29869753 |
Eosinophilia | 17.70 | 9.91 | 111 | 80366 | 22049 | 29849952 |
Visual impairment | 17.61 | 9.91 | 141 | 80336 | 30297 | 29841704 |
Mental fatigue | 17.43 | 9.91 | 7 | 80470 | 75 | 29871926 |
Muscle atrophy | 17.43 | 9.91 | 48 | 80429 | 6576 | 29865425 |
Sacroiliitis | 17.27 | 9.91 | 16 | 80461 | 844 | 29871157 |
Rash morbilliform | 17.27 | 9.91 | 27 | 80450 | 2475 | 29869526 |
Muscle tightness | 17.25 | 9.91 | 38 | 80439 | 4525 | 29867476 |
Bronchopulmonary aspergillosis | 17.18 | 9.91 | 72 | 80405 | 12212 | 29859789 |
Spinal muscular atrophy | 17.16 | 9.91 | 9 | 80468 | 185 | 29871816 |
Rash maculo-papular | 17.10 | 9.91 | 122 | 80355 | 25296 | 29846705 |
Pseudoporphyria | 17.03 | 9.91 | 10 | 80467 | 258 | 29871743 |
Respiratory arrest | 16.98 | 9.91 | 33 | 80444 | 29225 | 29842776 |
Dysuria | 16.83 | 9.91 | 111 | 80366 | 22430 | 29849571 |
Failure to suspend medication | 16.80 | 9.91 | 7 | 80470 | 83 | 29871918 |
Drug intolerance | 16.58 | 9.91 | 64 | 80413 | 45227 | 29826774 |
Magnesium deficiency | 16.58 | 9.91 | 7 | 80470 | 86 | 29871915 |
Malignant neoplasm progression | 16.48 | 9.91 | 120 | 80357 | 72167 | 29799834 |
Nasopharyngitis | 16.32 | 9.91 | 92 | 80385 | 58757 | 29813244 |
Muscle fatigue | 16.29 | 9.91 | 18 | 80459 | 1173 | 29870828 |
Ligament rupture | 16.28 | 9.91 | 16 | 80461 | 909 | 29871092 |
Graft versus host disease | 16.20 | 9.91 | 62 | 80415 | 10088 | 29861913 |
Sleep disorder | 16.18 | 9.91 | 117 | 80360 | 24362 | 29847639 |
Irritability | 16.16 | 9.91 | 23 | 80454 | 23027 | 29848974 |
Corneal opacity | 16.16 | 9.91 | 13 | 80464 | 566 | 29871435 |
Metastases to liver | 16.08 | 9.91 | 6 | 80471 | 11959 | 29860042 |
Haematospermia | 16.04 | 9.91 | 11 | 80466 | 374 | 29871627 |
Blood creatine phosphokinase increased | 16.03 | 9.91 | 62 | 80415 | 43786 | 29828215 |
Pyelonephritis | 15.98 | 9.91 | 41 | 80436 | 5385 | 29866616 |
Cerebral infarction | 15.96 | 9.91 | 29 | 80448 | 26344 | 29845657 |
Hepatitis cholestatic | 15.93 | 9.91 | 52 | 80425 | 7820 | 29864181 |
Cardiac arrest | 15.89 | 9.91 | 166 | 80311 | 92684 | 29779317 |
Joint stiffness | 15.62 | 9.91 | 58 | 80419 | 9303 | 29862698 |
COVID-19 | 15.58 | 9.91 | 15 | 80462 | 17863 | 29854138 |
Fluorosis | 15.58 | 9.91 | 6 | 80471 | 57 | 29871944 |
Coma | 15.57 | 9.91 | 56 | 80421 | 40393 | 29831608 |
Deep vein thrombosis | 15.50 | 9.91 | 97 | 80380 | 60404 | 29811597 |
Multiple-drug resistance | 15.33 | 9.91 | 28 | 80449 | 2913 | 29869088 |
Angina bullosa haemorrhagica | 15.31 | 9.91 | 6 | 80471 | 60 | 29871941 |
Systemic candida | 15.28 | 9.91 | 27 | 80450 | 2737 | 29869264 |
Cogwheel rigidity | 15.25 | 9.91 | 17 | 80460 | 1119 | 29870882 |
Increased viscosity of bronchial secretion | 15.23 | 9.91 | 9 | 80468 | 235 | 29871766 |
Skin injury | 15.20 | 9.91 | 16 | 80461 | 987 | 29871014 |
Hypoaesthesia | 15.17 | 9.91 | 217 | 80260 | 54013 | 29817988 |
Eye infection fungal | 15.12 | 9.91 | 10 | 80467 | 320 | 29871681 |
Rash | 14.92 | 9.91 | 644 | 79833 | 191245 | 29680756 |
Gingival recession | 14.90 | 9.91 | 11 | 80466 | 421 | 29871580 |
Stenotrophomonas infection | 14.82 | 9.91 | 20 | 80457 | 1604 | 29870397 |
Toxic encephalopathy | 14.80 | 9.91 | 36 | 80441 | 4573 | 29867428 |
Urine viscosity increased | 14.77 | 9.91 | 3 | 80474 | 0 | 29872001 |
Nail bed inflammation | 14.77 | 9.91 | 8 | 80469 | 176 | 29871825 |
Uveitis | 14.72 | 9.91 | 40 | 80437 | 5437 | 29866564 |
Epistaxis | 14.60 | 9.91 | 83 | 80394 | 52898 | 29819103 |
Venoocclusive liver disease | 14.59 | 9.91 | 45 | 80432 | 6568 | 29865433 |
Ligament injury | 14.58 | 9.91 | 10 | 80467 | 340 | 29871661 |
Loss of proprioception | 14.54 | 9.91 | 9 | 80468 | 256 | 29871745 |
Mastoiditis | 14.54 | 9.91 | 13 | 80464 | 655 | 29871346 |
Necrotising fasciitis | 14.51 | 9.91 | 30 | 80447 | 3419 | 29868582 |
Aortic aneurysm | 14.49 | 9.91 | 44 | 80433 | 6369 | 29865632 |
Pruritus | 14.49 | 9.91 | 418 | 80059 | 117786 | 29754215 |
Tenderness | 14.45 | 9.91 | 41 | 80436 | 5714 | 29866287 |
Kounis syndrome | 14.35 | 9.91 | 20 | 80457 | 1653 | 29870348 |
Treatment noncompliance | 14.21 | 9.91 | 29 | 80448 | 25224 | 29846777 |
Drug dependence | 14.20 | 9.91 | 22 | 80455 | 21273 | 29850728 |
Sepsis | 14.11 | 9.91 | 503 | 79974 | 145892 | 29726109 |
Plasma cell myeloma | 14.07 | 9.91 | 85 | 80392 | 53377 | 29818624 |
Inguinal mass | 13.95 | 9.91 | 5 | 80472 | 38 | 29871963 |
Drug ineffective for unapproved indication | 13.85 | 9.91 | 62 | 80415 | 10818 | 29861183 |
Somnolence | 13.85 | 9.91 | 180 | 80297 | 96583 | 29775418 |
Seizure | 13.79 | 9.91 | 184 | 80293 | 98291 | 29773710 |
Crystal nephropathy | 13.70 | 9.91 | 10 | 80467 | 376 | 29871625 |
Pulmonary arterial hypertension | 13.66 | 9.91 | 4 | 80473 | 9297 | 29862704 |
Mycobacterium ulcerans infection | 13.52 | 9.91 | 5 | 80472 | 42 | 29871959 |
Pulmonary valve disease | 13.51 | 9.91 | 6 | 80471 | 84 | 29871917 |
Joint instability | 13.49 | 9.91 | 10 | 80467 | 385 | 29871616 |
Drug level increased | 13.47 | 9.91 | 90 | 80387 | 18264 | 29853737 |
Hyperkalaemia | 13.45 | 9.91 | 113 | 80364 | 65897 | 29806104 |
Stomatococcal infection | 13.43 | 9.91 | 7 | 80470 | 142 | 29871859 |
Underdose | 13.38 | 9.91 | 8 | 80469 | 12133 | 29859868 |
Staphylococcal infection | 13.35 | 9.91 | 132 | 80345 | 30092 | 29841909 |
Bladder spasm | 13.29 | 9.91 | 14 | 80463 | 864 | 29871137 |
Epididymitis | 13.27 | 9.91 | 23 | 80454 | 2296 | 29869705 |
Poisoning | 13.26 | 9.91 | 7 | 80470 | 11375 | 29860626 |
Subdural haematoma | 13.23 | 9.91 | 19 | 80458 | 18953 | 29853048 |
Endocarditis candida | 13.20 | 9.91 | 6 | 80471 | 89 | 29871912 |
Leukocyturia | 13.13 | 9.91 | 11 | 80466 | 507 | 29871494 |
Blood triglycerides increased | 13.13 | 9.91 | 11 | 80466 | 14006 | 29857995 |
Withdrawal syndrome | 12.99 | 9.91 | 7 | 80470 | 11243 | 29860758 |
Escherichia urinary tract infection | 12.93 | 9.91 | 26 | 80451 | 2906 | 29869095 |
Meningitis | 12.85 | 9.91 | 34 | 80443 | 4548 | 29867453 |
Lung neoplasm malignant | 12.84 | 9.91 | 13 | 80464 | 15119 | 29856882 |
Coronary artery occlusion | 12.80 | 9.91 | 7 | 80470 | 11150 | 29860851 |
Sputum increased | 12.76 | 9.91 | 20 | 80457 | 1837 | 29870164 |
Roseolovirus test positive | 12.74 | 9.91 | 6 | 80471 | 97 | 29871904 |
Vertebral artery hypoplasia | 12.70 | 9.91 | 3 | 80474 | 3 | 29871998 |
Perineurial cyst | 12.70 | 9.91 | 3 | 80474 | 3 | 29871998 |
Mucosal hyperaemia | 12.70 | 9.91 | 3 | 80474 | 3 | 29871998 |
Post infection glomerulonephritis | 12.70 | 9.91 | 3 | 80474 | 3 | 29871998 |
Pudendal canal syndrome | 12.70 | 9.91 | 3 | 80474 | 3 | 29871998 |
Musculoskeletal pain | 12.65 | 9.91 | 133 | 80344 | 30807 | 29841194 |
Osteonecrosis of jaw | 12.64 | 9.91 | 19 | 80458 | 18599 | 29853402 |
Klebsiella infection | 12.62 | 9.91 | 44 | 80433 | 6843 | 29865158 |
Polyneuropathy | 12.60 | 9.91 | 64 | 80413 | 11759 | 29860242 |
Fungaemia | 12.60 | 9.91 | 22 | 80455 | 2209 | 29869792 |
Vanishing bile duct syndrome | 12.60 | 9.91 | 12 | 80465 | 656 | 29871345 |
Febrile bone marrow aplasia | 12.55 | 9.91 | 49 | 80428 | 8048 | 29863953 |
Pseudomonal sepsis | 12.51 | 9.91 | 26 | 80451 | 2974 | 29869027 |
Cervicobrachial syndrome | 12.46 | 9.91 | 9 | 80468 | 333 | 29871668 |
Generalised oedema | 12.44 | 9.91 | 64 | 80413 | 11821 | 29860180 |
Hepatic infarction | 12.34 | 9.91 | 7 | 80470 | 169 | 29871832 |
Sensory disturbance | 12.32 | 9.91 | 39 | 80438 | 5772 | 29866229 |
Oligoarthritis | 12.25 | 9.91 | 5 | 80472 | 56 | 29871945 |
Cough | 12.24 | 9.91 | 251 | 80226 | 125391 | 29746610 |
Scrotal pain | 12.23 | 9.91 | 13 | 80464 | 811 | 29871190 |
Fluid retention | 12.21 | 9.91 | 31 | 80446 | 24967 | 29847034 |
Accidental exposure to product | 12.12 | 9.91 | 6 | 80471 | 10109 | 29861892 |
Breast inflammation | 12.11 | 9.91 | 4 | 80473 | 23 | 29871978 |
Incorrect dose administered | 12.10 | 9.91 | 44 | 80433 | 31642 | 29840359 |
Rotator cuff syndrome | 12.10 | 9.91 | 37 | 80440 | 5376 | 29866625 |
Therapeutic response decreased | 12.04 | 9.91 | 30 | 80447 | 24319 | 29847682 |
Resting tremor | 12.02 | 9.91 | 11 | 80466 | 571 | 29871430 |
Head discomfort | 12.00 | 9.91 | 25 | 80452 | 2865 | 29869136 |
Jaundice cholestatic | 11.99 | 9.91 | 33 | 80444 | 4518 | 29867483 |
Ligament disorder | 11.96 | 9.91 | 6 | 80471 | 112 | 29871889 |
Electrocardiogram QT prolonged | 11.93 | 9.91 | 148 | 80329 | 35687 | 29836314 |
Labelled drug-drug interaction medication error | 11.91 | 9.91 | 58 | 80419 | 10480 | 29861521 |
Flushing | 11.91 | 9.91 | 40 | 80437 | 29452 | 29842549 |
Tenosynovitis | 11.88 | 9.91 | 28 | 80449 | 3487 | 29868514 |
Glomerular filtration rate decreased | 11.82 | 9.91 | 8 | 80469 | 11354 | 29860647 |
Visual acuity reduced | 11.81 | 9.91 | 78 | 80399 | 15768 | 29856233 |
Retinopathy hypertensive | 11.72 | 9.91 | 8 | 80469 | 270 | 29871731 |
Inflammation | 11.65 | 9.91 | 100 | 80377 | 21926 | 29850075 |
Nephritis allergic | 11.63 | 9.91 | 9 | 80468 | 370 | 29871631 |
Lip erosion | 11.60 | 9.91 | 11 | 80466 | 598 | 29871403 |
Screaming | 11.55 | 9.91 | 16 | 80461 | 1315 | 29870686 |
Anal stenosis | 11.54 | 9.91 | 6 | 80471 | 121 | 29871880 |
Throat tightness | 11.53 | 9.91 | 44 | 80433 | 7148 | 29864853 |
Expanded disability status scale score increased | 11.51 | 9.91 | 7 | 80470 | 193 | 29871808 |
Product administration error | 11.48 | 9.91 | 13 | 80464 | 14364 | 29857637 |
Arteriosclerosis coronary artery | 11.45 | 9.91 | 8 | 80469 | 11168 | 29860833 |
Myocardial ischaemia | 11.44 | 9.91 | 18 | 80459 | 17299 | 29854702 |
Neuropsychiatric symptoms | 11.44 | 9.91 | 10 | 80467 | 489 | 29871512 |
Tooth injury | 11.43 | 9.91 | 12 | 80465 | 738 | 29871263 |
Idiosyncratic drug reaction | 11.42 | 9.91 | 10 | 80467 | 490 | 29871511 |
Urinary retention | 11.41 | 9.91 | 137 | 80340 | 32780 | 29839221 |
Aspartate aminotransferase | 11.33 | 9.91 | 6 | 80471 | 126 | 29871875 |
Walking disability | 11.31 | 9.91 | 12 | 80465 | 747 | 29871254 |
Renal abscess | 11.22 | 9.91 | 7 | 80470 | 202 | 29871799 |
Eye excision | 11.21 | 9.91 | 4 | 80473 | 30 | 29871971 |
Food allergy | 11.19 | 9.91 | 13 | 80464 | 895 | 29871106 |
Jaundice | 11.17 | 9.91 | 135 | 80342 | 32351 | 29839650 |
Microbiology test abnormal | 11.17 | 9.91 | 3 | 80474 | 7 | 29871994 |
Glutathione decreased | 11.17 | 9.91 | 3 | 80474 | 7 | 29871994 |
Blood catecholamines decreased | 11.17 | 9.91 | 3 | 80474 | 7 | 29871994 |
Hepatic amoebiasis | 11.13 | 9.91 | 5 | 80472 | 72 | 29871929 |
Angina unstable | 11.12 | 9.91 | 10 | 80467 | 12300 | 29859701 |
Aortic aneurysm rupture | 11.10 | 9.91 | 14 | 80463 | 1050 | 29870951 |
Abdominal pain lower | 11.10 | 9.91 | 50 | 80427 | 8748 | 29863253 |
Peripheral sensory neuropathy | 11.07 | 9.91 | 38 | 80439 | 5863 | 29866138 |
Injection site bruising | 11.07 | 9.91 | 3 | 80474 | 7335 | 29864666 |
Hepatocellular carcinoma | 11.07 | 9.91 | 6 | 80471 | 9604 | 29862397 |
Prothrombin time shortened | 11.04 | 9.91 | 17 | 80460 | 1538 | 29870463 |
Hyperoxaluria | 11.03 | 9.91 | 6 | 80471 | 133 | 29871868 |
Neutropenia | 11.02 | 9.91 | 436 | 80041 | 128104 | 29743897 |
Aortic intramural haematoma | 10.99 | 9.91 | 4 | 80473 | 32 | 29871969 |
Oesophageal mucosa erythema | 10.99 | 9.91 | 4 | 80473 | 32 | 29871969 |
Hyperthyroidism | 10.99 | 9.91 | 4 | 80473 | 8094 | 29863907 |
Hair colour changes | 10.95 | 9.91 | 17 | 80460 | 1548 | 29870453 |
Corynebacterium infection | 10.93 | 9.91 | 9 | 80468 | 405 | 29871596 |
Hyperglycaemia | 10.89 | 9.91 | 53 | 80424 | 35147 | 29836854 |
Fear of death | 10.88 | 9.91 | 11 | 80466 | 647 | 29871354 |
Lactic acidosis | 10.86 | 9.91 | 45 | 80432 | 31168 | 29840833 |
Pneumonia pseudomonal | 10.79 | 9.91 | 27 | 80450 | 3491 | 29868510 |
Tongue coated | 10.78 | 9.91 | 7 | 80470 | 217 | 29871784 |
Arteriosclerosis | 10.78 | 9.91 | 8 | 80469 | 10825 | 29861176 |
Nervous system disorder | 10.77 | 9.91 | 66 | 80411 | 13003 | 29858998 |
Guillain-Barre syndrome | 10.67 | 9.91 | 34 | 80443 | 5049 | 29866952 |
Colour blindness | 10.67 | 9.91 | 7 | 80470 | 221 | 29871780 |
Cholestatic liver injury | 10.66 | 9.91 | 17 | 80460 | 1584 | 29870417 |
Stenotrophomonas test positive | 10.62 | 9.91 | 8 | 80469 | 316 | 29871685 |
Keratitis fungal | 10.60 | 9.91 | 5 | 80472 | 81 | 29871920 |
Inappropriate schedule of product administration | 10.54 | 9.91 | 63 | 80414 | 39665 | 29832336 |
Vasculitis | 10.53 | 9.91 | 46 | 80431 | 7944 | 29864057 |
Yawning | 10.49 | 9.91 | 10 | 80467 | 547 | 29871454 |
Alcohol intolerance | 10.45 | 9.91 | 9 | 80468 | 431 | 29871570 |
Osteonecrosis | 10.44 | 9.91 | 17 | 80460 | 16118 | 29855883 |
Enterocolitis haemorrhagic | 10.42 | 9.91 | 13 | 80464 | 964 | 29871037 |
Infusion related reaction | 10.41 | 9.91 | 65 | 80412 | 40499 | 29831502 |
Prescribed overdose | 10.37 | 9.91 | 5 | 80472 | 8556 | 29863445 |
Obesity | 10.36 | 9.91 | 5 | 80472 | 8550 | 29863451 |
Pneumoperitoneum | 10.36 | 9.91 | 17 | 80460 | 1623 | 29870378 |
Haemolytic uraemic syndrome | 10.36 | 9.91 | 19 | 80458 | 1983 | 29870018 |
Chondritis | 10.35 | 9.91 | 6 | 80471 | 151 | 29871850 |
Hypofibrinogenaemia | 10.32 | 9.91 | 17 | 80460 | 1628 | 29870373 |
Protein total abnormal | 10.29 | 9.91 | 8 | 80469 | 331 | 29871670 |
Agranulocytosis | 10.26 | 9.91 | 97 | 80380 | 21845 | 29850156 |
Atrioventricular block complete | 10.20 | 9.91 | 5 | 80472 | 8472 | 29863529 |
Blood urine | 10.19 | 9.91 | 9 | 80468 | 446 | 29871555 |
Hyperinsulinaemia | 10.18 | 9.91 | 5 | 80472 | 89 | 29871912 |
Nutritional condition abnormal | 10.11 | 9.91 | 9 | 80468 | 451 | 29871550 |
Enterocolitis bacterial | 10.10 | 9.91 | 7 | 80470 | 242 | 29871759 |
Peritoneal neoplasm | 10.03 | 9.91 | 4 | 80473 | 42 | 29871959 |
Anal inflammation | 10.03 | 9.91 | 8 | 80469 | 344 | 29871657 |
Necrotising retinitis | 9.99 | 9.91 | 11 | 80466 | 714 | 29871287 |
Penile blister | 9.98 | 9.91 | 5 | 80472 | 93 | 29871908 |
Blood cholesterol increased | 9.97 | 9.91 | 19 | 80458 | 16951 | 29855050 |
Skin depigmentation | 9.97 | 9.91 | 8 | 80469 | 347 | 29871654 |
Flavobacterium infection | 9.94 | 9.91 | 5 | 80472 | 94 | 29871907 |
Gynaecomastia | 9.93 | 9.91 | 5 | 80472 | 8346 | 29863655 |
Oliguria | 9.93 | 9.91 | 43 | 80434 | 7396 | 29864605 |
Source | Code | Description |
---|---|---|
ATC | J01MA02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Fluoroquinolones |
ATC | S01AE03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Fluoroquinolones |
ATC | S02AA15 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
ATC | S03AA07 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives |
ATC | J01RA10 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
ATC | J01RA11 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
ATC | J01RA12 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
FDA CS | M0023650 | Quinolones |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D065609 | Cytochrome P-450 CYP1A2 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D059005 | Topoisomerase II Inhibitors |
FDA EPC | N0000175937 | Quinolone Antimicrobial |
CHEBI has role | CHEBI:35441 | anti-infective drugs |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:50750 | inhibitors of type ii topoisomerase |
CHEBI has role | CHEBI:53559 | topoisomerase iv inhibitors |
CHEBI has role | CHEBI:33281 | antibiotics |
CHEBI has role | CHEBI:35703 | xenobiotic |
CHEBI has role | CHEBI:59517 | dna synthesis inhibitors |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Otitis externa | indication | 3135009 | |
Typhoid fever | indication | 4834000 | DOID:13258 |
Septicemia due to Escherichia coli | indication | 9323009 | |
Prostatitis | indication | 9713002 | DOID:14654 |
Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
Enteric campylobacteriosis | indication | 18081009 | |
Infectious diarrheal disease | indication | 19213003 | DOID:13250 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Acute gonococcal urethritis | indication | 29864006 | |
Acute bacterial peritonitis | indication | 31860008 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Shigellosis | indication | 36188001 | |
Cystitis | indication | 38822007 | DOID:1679 |
Pneumonia due to Pseudomonas | indication | 41381004 | |
Lower respiratory tract infection | indication | 50417007 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Acute maxillary sinusitis | indication | 68272006 | DOID:2050 |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Abdominal abscess | indication | 75100008 | |
Acute bacterial sinusitis | indication | 75498004 | |
Infective otitis externa | indication | 86981007 | DOID:9463 |
Infection of bone | indication | 111253001 | |
Infectious disease of abdomen | indication | 128070006 | |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Acute Moraxella catarrhalis bronchitis | indication | 195722003 | |
Proteus pneumonia | indication | 195888009 | |
Malignant otitis externa due to Pseudomonas aeruginosa | indication | 232230009 | |
Acute bacterial bronchitis | indication | 233598009 | |
Infective cystitis | indication | 236620008 | |
Chancroid | indication | 266143009 | DOID:13778 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Infectious disorder of joint | indication | 363162000 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Anthrax | indication | 409498004 | DOID:7427 |
Acute osteomyelitis | indication | 409780002 | |
Nosocomial pneumonia | indication | 425464007 | |
Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
Complicated UTI with Pseudomonas Aeruginosa | indication | ||
Staphylococcus Epidermidis Urinary Tract Infection | indication | ||
Pseudomonas Aeruginosa Joint Infection | indication | ||
Complicated Proteus UTI | indication | ||
Skin and Skin Structure Providencia Infection | indication | ||
Complicated Bacterial Peritonitis | indication | ||
Staphylococcus Saprophyticus Urinary Tract Infection | indication | ||
Haemophilus Parainfluenzae Pneumonia | indication | ||
Enterobacter Pneumonia | indication | ||
Skin and Skin Structure Citrobacter Infection | indication | ||
Moraxella Catarrhalis Chronic Bronchitis | indication | ||
Diarrhea due to E. Coli | indication | ||
Klebsiella Nosocomial Pneumonia | indication | ||
Citrobacter Urinary Tract Infection | indication | ||
Enterococcus Urinary Tract Infection | indication | ||
Serratia Joint Infection | indication | ||
Skin and Skin Structure Proteus Infection | indication | ||
EnterobacterJoint Infection | indication | ||
Enterobacter Osteomyelitis | indication | ||
Nosocomial Pneumonia due to Haemophilus Influenzae | indication | ||
Complicated Bacteroides Peritonitis | indication | ||
Complicated E. Coli Peritonitis | indication | ||
Morganella Morganii Urinary Tract Infection | indication | ||
Bacterial Corneal Ulcer Infection | indication | ||
E. Coli Cystitis | indication | ||
Staphylococcus Aureus Otitis Externa | indication | ||
Staphylococcus Cystitis | indication | ||
Chronic Bacterial Prostatitis | indication | ||
Pseudomonas Aeruginosa Urinary Tract Infection | indication | ||
Gram-Negative Aerobic Bacillary Pneumonia | indication | ||
Serratia Osteomyelitis | indication | ||
Staphylococcus Epidermidis Skin and Skin Structure Infection | indication | ||
Enterococcus Complicated UTI | indication | ||
Providencia Urinary Tract Infection | indication | ||
Complicated Klebsiella Peritonitis | indication | ||
Skin and Skin Structure Serratia Infection | indication | ||
Proteus Prostatitis | indication | ||
E. Coli Pyelonephritis | indication | ||
Skin and Skin Structure Morganella Morganii Infection | indication | ||
Serratia Urinary Tract Infection | indication | ||
Pseudomonas Aeruginosa Osteomyelitis | indication | ||
Inhalational anthrax | off-label use | 11389007 | |
Traveler's diarrhea | off-label use | 11840006 | |
Salmonella septicemia | off-label use | 49786009 | |
Cutaneous anthrax | off-label use | 84980006 | DOID:7426 |
Gastrointestinal anthrax | off-label use | 111798006 | DOID:13386 |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Ventilator-acquired pneumonia | off-label use | 429271009 | |
Diabetic Foot Infection | off-label use | ||
Prevention of Meningococcal Meningitis | off-label use | ||
Achilles tendinitis | contraindication | 11654001 | |
Lowered convulsive threshold | contraindication | 19260006 | |
Torsades de pointes | contraindication | 31722008 | |
Transplantation of heart | contraindication | 32413006 | |
Tendinitis | contraindication | 34840004 | DOID:971 |
Hypokalemia | contraindication | 43339004 | |
Transplant of kidney | contraindication | 70536003 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Transplant of lung | contraindication | 88039007 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Prolonged QT interval | contraindication | 111975006 | |
Superimposed infection | contraindication | 193198003 | |
Peripheral nerve disease | contraindication | 302226006 | |
Viral ear infection | contraindication | 312137007 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Traumatic rupture of tendon | contraindication | 415749005 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Shoulder Tendonitis | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.12 | acidic |
pKa2 | 8.54 | Basic |
pKa3 | 1.37 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
6% (60MG/ML) | OTIPRIO | OTONOMY INC | N207986 | Dec. 10, 2015 | RX | INJECTABLE, SUSPENSION | OTIC | March 2, 2021 | TREATMENT OF ACUTE OTITIS EXTERNULL IN PATIENTS 6 MONTHS OF AGE AND OLDER DUE TO PSEUDOMONULLS AERUGINOSA AND STAPHYLOCOCCUS AUREUS |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase II | Enzyme | EC50 | 7.52 | CHEMBL | |||||
DNA gyrase subunit A | Enzyme | INHIBITOR | IC50 | 5.75 | WOMBAT-PK | CHEMBL | |||
DNA topoisomerase 4 subunit A | Enzyme | INHIBITOR | IC50 | 6 | WOMBAT-PK | ||||
DNA topoisomerase 4 subunit A | Enzyme | IC50 | 5.66 | WOMBAT-PK | |||||
DNA topoisomerase 4 subunit A | Enzyme | IC50 | 5.60 | WOMBAT-PK | |||||
DNA gyrase subunit A | Enzyme | IC50 | 6.20 | WOMBAT-PK | |||||
GABA-A receptor; anion channel | Ion channel | IC50 | 6.39 | CHEMBL | |||||
Multidrug resistance protein mdtK | Unclassified | Kd | 4.04 | CHEMBL | |||||
Histamine H3 receptor | GPCR | Ki | 9.18 | CHEMBL |
ID | Source |
---|---|
4019307 | VUID |
N0000147503 | NUI |
D00186 | KEGG_DRUG |
86393-32-0 | SECONDARY_CAS_RN |
4019306 | VANDF |
4019307 | VANDF |
C0008809 | UMLSCUI |
CHEBI:100241 | CHEBI |
CPF | PDB_CHEM_ID |
CHEMBL8 | ChEMBL_ID |
CHEMBL1202 | ChEMBL_ID |
CHEMBL1077975 | ChEMBL_ID |
DB00537 | DRUGBANK_ID |
D002939 | MESH_DESCRIPTOR_UI |
2764 | PUBCHEM_CID |
10902 | IUPHAR_LIGAND_ID |
5446 | INN_ID |
5E8K9I0O4U | UNII |
235851 | RXNORM |
31644 | MMSL |
4451 | MMSL |
4452 | MMSL |
46904 | MMSL |
76342 | MMSL |
d00011 | MMSL |
002882 | NDDF |
003577 | NDDF |
004125 | NDDF |
20450009 | SNOMEDCT_US |
372840008 | SNOMEDCT_US |
428384006 | SNOMEDCT_US |
7577004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CILOXAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0654 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 19 sections |
Ciloxan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0656 | SOLUTION/ DROPS | 3 mg | OPHTHALMIC | NDA | 21 sections |
CIPROHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-8531 | SUSPENSION | 2 mg | AURICULAR (OTIC) | NDA | 16 sections |
CIPRODEX | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-8533 | SUSPENSION/ DROPS | 3 mg | AURICULAR (OTIC) | NDA | 27 sections |
CIPRODEX | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0799 | SUSPENSION/ DROPS | 3 mg | AURICULAR (OTIC) | NDA | 28 sections |
CILOXAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0841 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 20 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9927 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 30 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9928 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 30 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9929 | TABLET, FILM COATED | 750 mg | ORAL | ANDA | 30 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0172-5311 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0172-5312 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0172-5313 | TABLET, FILM COATED | 750 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7098 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-7187 | SOLUTION/ DROPS | 3 mg | OPHTHALMIC | ANDA | 24 sections |
CIPROFLOXACIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4777 | INJECTION, SOLUTION | 2 mg | INTRAVENOUS | ANDA | 34 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8147 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8367 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 30 sections |
Ciprofloxacin and Dexamethasone | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0781-6186 | SUSPENSION/ DROPS | 3 mg | AURICULAR (OTIC) | NDA authorized generic | 27 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6378 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7083 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 30 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-036 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-079 | TABLET | 500 mg | ORAL | ANDA | 27 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-147 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 27 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-432 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-603 | TABLET | 250 mg | ORAL | ANDA | 27 sections |
CIPROFLOXACIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-604 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 28 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-605 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 17 sections |
Ciprofloxacin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-606 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
CIPROFLOXACIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-607 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Ciprofloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-608 | TABLET | 500 mg | ORAL | ANDA | 27 sections |