ciprofloxacin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 659 85721-33-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ciprofloxacin
  • ciprofloxacin hydrochloride
  • ciprofloxacillin
  • ciprofloxacine
  • ciprofloxacin hydrochloride monohydrate
  • ciprofloxacin HCl
  • ciprofloxacin lactate
A broad-spectrum antimicrobial carboxyfluoroquinoline.
  • Molecular weight: 331.35
  • Formula: C17H18FN3O3
  • CLOGP: -0.73
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 72.88
  • ALOGS: -2.39
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O
0.80 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.15 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 65 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.49 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.80 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 22, 1987 FDA BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1193.66 9.49 2045 103798 241780 46338439
Tendon pain 616.24 9.49 235 105608 2615 46577604
Tendonitis 535.28 9.49 358 105485 13919 46566300
Abortion spontaneous 385.58 9.49 485 105358 43161 46537058
Drug reaction with eosinophilia and systemic symptoms 279.64 9.49 340 105503 29208 46551011
Rheumatoid arthritis 276.05 9.49 100 105743 240115 46340104
Tendon rupture 251.68 9.49 178 105665 7581 46572638
Toxic epidermal necrolysis 213.47 9.49 258 105585 22020 46558199
Tendon disorder 193.80 9.49 128 105715 4867 46575352
Tubulointerstitial nephritis 183.75 9.49 196 105647 14592 46565627
Drug interaction 179.66 9.49 922 104921 202172 46378047
Pathogen resistance 169.24 9.49 127 105716 5933 46574286
Drug ineffective 141.93 9.49 929 104914 676909 45903310
Clostridium difficile colitis 134.16 9.49 187 105656 18366 46561853
Death 132.15 9.49 360 105483 335188 46245031
Acute kidney injury 128.08 9.49 944 104899 234911 46345308
Completed suicide 121.35 9.49 92 105751 145828 46434391
Dysbiosis 104.05 9.49 41 105802 501 46579718
Cholecystitis chronic 102.86 9.49 123 105720 10376 46569843
Urinary tract infection 97.82 9.49 842 105001 219424 46360795
Clostridium difficile infection 88.90 9.49 184 105659 24919 46555300
Fall 88.78 9.49 414 105429 328683 46251536
Stevens-Johnson syndrome 87.53 9.49 175 105668 23122 46557097
Pemphigus 85.71 9.49 4 105839 45270 46534949
Tinnitus 78.95 9.49 186 105657 27487 46552732
Tendon discomfort 78.59 9.49 23 105820 101 46580118
Early retirement 77.90 9.49 16 105827 4 46580215
Injection site pain 77.59 9.49 77 105766 107075 46473144
Therapeutic product effect decreased 71.33 9.49 50 105793 82551 46497668
Myalgia 68.56 9.49 496 105347 122592 46457627
Hand deformity 65.62 9.49 3 105840 34571 46545648
Paraesthesia 64.70 9.49 472 105371 116965 46463254
Drug resistance 64.69 9.49 130 105713 17238 46562981
Geotrichum infection 64.48 9.49 28 105815 444 46579775
Injury 64.42 9.49 233 105610 43794 46536425
Joint noise 63.87 9.49 55 105788 3132 46577087
Panic attack 63.21 9.49 141 105702 20101 46560118
Musculoskeletal injury 60.74 9.49 19 105824 109 46580110
Intentional overdose 60.59 9.49 36 105807 64908 46515311
Rash maculo-papular 60.49 9.49 169 105674 27705 46552514
Disturbance in attention 60.46 9.49 183 105660 31377 46548842
Multiple organ dysfunction syndrome 59.71 9.49 254 105589 51456 46528763
Therapeutic product effect incomplete 59.09 9.49 54 105789 78099 46502120
Pseudomembranous colitis 55.79 9.49 51 105792 3144 46577075
Connective tissue disorder 54.51 9.49 32 105811 984 46579235
Injection site erythema 54.42 9.49 53 105790 74374 46505845
Off label use 54.30 9.49 575 105268 379266 46200953
Tendon injury 53.58 9.49 37 105806 1515 46578704
Febrile neutropenia 53.07 9.49 382 105461 94245 46485974
Pouchitis 52.97 9.49 24 105819 423 46579796
Contraindicated product administered 52.81 9.49 62 105781 79885 46500334
Synovitis 52.68 9.49 37 105806 61038 46519181
Neuropathy peripheral 52.17 9.49 369 105474 90524 46489695
Multiple chemical sensitivity 51.90 9.49 11 105832 5 46580214
Pseudomonas infection 51.56 9.49 85 105758 9673 46570546
Torsade de pointes 50.16 9.49 95 105748 12059 46568160
Glossodynia 49.96 9.49 19 105824 44354 46535865
Dermatitis exfoliative 49.60 9.49 63 105780 5653 46574566
Drug intolerance 49.01 9.49 170 105673 146879 46433340
Nasopharyngitis 48.70 9.49 182 105661 153816 46426403
Product dose omission issue 48.34 9.49 207 105636 168313 46411906
Emotional distress 47.05 9.49 165 105678 30542 46549677
Fistula 46.74 9.49 73 105770 7937 46572282
Food intolerance 46.24 9.49 40 105803 2292 46577927
Psoriasis 45.72 9.49 67 105776 78537 46501682
Renal tubular necrosis 45.52 9.49 85 105758 10674 46569545
Drug abuse 45.38 9.49 46 105797 63362 46516857
Pyrexia 45.33 9.49 1072 104771 347730 46232489
Burning sensation 45.12 9.49 210 105633 44201 46536018
Pyelonephritis 44.65 9.49 104 105739 15253 46564966
Toxicity to various agents 43.07 9.49 292 105551 211474 46368745
Injection site swelling 42.60 9.49 19 105824 40308 46539911
Device expulsion 42.40 9.49 6 105837 27536 46552683
Wrong technique in product usage process 41.86 9.49 37 105806 54385 46525834
Diverticulitis 41.84 9.49 167 105676 32872 46547347
Intentional product misuse 41.38 9.49 28 105815 47100 46533119
Anxiety 40.93 9.49 609 105234 181348 46398871
Weight increased 40.73 9.49 213 105630 164260 46415959
Abdominal pain 40.68 9.49 740 105103 229291 46350928
Impaired work ability 40.55 9.49 89 105754 12547 46567672
Trimethylaminuria 40.40 9.49 15 105828 154 46580065
Infusion related reaction 40.14 9.49 108 105735 101100 46479119
Asthma 39.15 9.49 94 105749 91448 46488771
Cystitis 38.77 9.49 194 105649 42047 46538172
Injection site reaction 38.68 9.49 31 105812 47818 46532401
Anal abscess 38.58 9.49 44 105799 3528 46576691
Anal fistula 38.21 9.49 38 105805 2603 46577616
Acute generalised exanthematous pustulosis 38.18 9.49 73 105770 9332 46570887
Cardio-respiratory arrest 37.87 9.49 48 105795 59821 46520398
Breast cancer 37.41 9.49 29 105814 45489 46534730
Suicide attempt 37.08 9.49 42 105801 54994 46525225
Muscle atrophy 36.97 9.49 56 105787 5928 46574291
Biliary dyskinesia 36.66 9.49 38 105805 2735 46577484
Alopecia 35.53 9.49 219 105624 162195 46418024
Arthropathy 35.41 9.49 88 105755 84612 46495607
Segmental diverticular colitis 35.31 9.49 13 105830 130 46580089
Aspergillus infection 35.04 9.49 59 105784 6831 46573388
Therapeutic response decreased 34.81 9.49 28 105815 43117 46537102
Pulmonary eosinophilia 34.65 9.49 15 105828 236 46579983
Pedal pulse abnormal 34.37 9.49 13 105830 141 46580078
Psoriatic arthropathy 34.16 9.49 20 105823 36359 46543860
Weight bearing difficulty 33.66 9.49 33 105810 2222 46577997
Factor V inhibition 33.35 9.49 13 105830 154 46580065
Nephritis allergic 33.35 9.49 13 105830 154 46580065
Ectropion 32.69 9.49 13 105830 163 46580056
Anti-cyclic citrullinated peptide antibody positive 32.40 9.49 3 105840 19142 46561077
Muscular weakness 32.12 9.49 334 105509 91510 46488709
Factor V deficiency 31.72 9.49 11 105832 91 46580128
Injection site bruising 31.51 9.49 21 105822 35615 46544604
Osteoporosis 30.76 9.49 28 105815 40580 46539639
Gastroenteritis pseudomonas 30.55 9.49 6 105837 0 46580219
Fat tissue decreased 30.32 9.49 7 105836 8 46580211
Infective pulmonary exacerbation of cystic fibrosis 30.13 9.49 72 105771 10735 46569484
Loss of employment 30.01 9.49 24 105819 1232 46578987
Colitis 29.79 9.49 165 105678 37182 46543037
Chronic kidney disease 29.61 9.49 176 105667 40695 46539524
Systemic lupus erythematosus 29.42 9.49 65 105778 65115 46515104
Muscle twitching 28.97 9.49 86 105757 14586 46565633
Drug-induced liver injury 28.80 9.49 124 105719 25244 46554975
Knee arthroplasty 28.59 9.49 9 105834 23656 46556563
Joint swelling 28.52 9.49 240 105603 165833 46414386
Injection site pruritus 28.24 9.49 29 105814 39714 46540505
Thrombocytopenia 28.18 9.49 423 105420 126158 46454061
Calcium ionised decreased 28.15 9.49 13 105830 240 46579979
Sphingomonas paucimobilis infection 28.12 9.49 6 105837 3 46580216
Bacterial colitis 28.02 9.49 9 105834 57 46580162
Headache 27.91 9.49 849 104994 477503 46102716
Nerve injury 27.89 9.49 57 105786 7648 46572571
Moraxella test positive 27.66 9.49 7 105836 15 46580204
Mineral deficiency 27.35 9.49 7 105836 16 46580203
Coma 27.32 9.49 57 105786 58292 46521927
Muscle contractions involuntary 27.30 9.49 28 105815 1990 46578229
Anorectal ulcer 27.13 9.49 9 105834 64 46580155
Non-consummation 27.13 9.49 9 105834 64 46580155
Bladder pain 27.04 9.49 24 105819 1423 46578796
Procedural anxiety 26.74 9.49 16 105827 510 46579709
Malignant neoplasm progression 26.71 9.49 68 105775 64858 46515361
Wound 26.36 9.49 35 105808 42767 46537452
Osteochondrosis 26.35 9.49 20 105823 950 46579269
Linear IgA disease 26.29 9.49 23 105820 1338 46578881
Klebsiella infection 26.17 9.49 51 105792 6611 46573608
Fungaemia 25.81 9.49 27 105816 1964 46578255
Mitochondrial cytopathy 25.79 9.49 13 105830 293 46579926
Megacolon 25.71 9.49 25 105818 1666 46578553
Pericarditis 25.70 9.49 11 105832 23916 46556303
Flank pain 25.62 9.49 72 105771 11841 46568378
Hyperacusis 25.47 9.49 26 105817 1838 46578381
Inappropriate schedule of product administration 25.30 9.49 70 105773 64943 46515276
Intentional product use issue 25.19 9.49 51 105792 52729 46527490
Asthma-chronic obstructive pulmonary disease overlap syndrome 25.18 9.49 15 105828 474 46579745
Acute hepatic failure 25.10 9.49 82 105761 14639 46565580
Neutropenia 24.68 9.49 459 105384 142745 46437474
Enterococcal infection 24.48 9.49 51 105792 6936 46573283
Chemical burns of eye 24.35 9.49 8 105835 55 46580164
Cardiac failure congestive 24.31 9.49 116 105727 91634 46488585
Hypertension 24.18 9.49 307 105536 196049 46384170
Blood pressure increased 24.09 9.49 178 105665 126488 46453731
Pregnancy 23.98 9.49 16 105827 27121 46553098
Idiopathic intracranial hypertension 23.93 9.49 29 105814 2480 46577739
Treatment failure 23.90 9.49 119 105724 92968 46487251
Accidental exposure to product 23.77 9.49 9 105834 21072 46559147
Hip arthroplasty 23.53 9.49 6 105837 18106 46562113
Gastrointestinal scarring 23.43 9.49 11 105832 211 46580008
Total lung capacity increased 23.36 9.49 17 105826 757 46579462
Pulmonary arterial hypertension 23.30 9.49 15 105828 25913 46554306
Diaphragmatic rupture 23.25 9.49 11 105832 215 46580004
Product quality issue 23.15 9.49 28 105815 35620 46544599
Femur fracture 23.05 9.49 30 105813 36967 46543252
Oliguria 22.97 9.49 57 105786 8702 46571517
Hypercreatininaemia 22.40 9.49 13 105830 391 46579828
Peripheral swelling 22.21 9.49 240 105603 157831 46422388
Tendon necrosis 22.00 9.49 5 105838 5 46580214
Meningitis candida 21.98 9.49 7 105836 43 46580176
Fixed eruption 21.68 9.49 17 105826 848 46579371
Acinetobacter infection 21.58 9.49 21 105822 1401 46578818
Bone marrow granuloma 21.57 9.49 6 105837 21 46580198
Gastroenteritis staphylococcal 21.56 9.49 8 105835 82 46580137
Diarrhoea 21.55 9.49 1508 104335 558094 46022125
Activated partial thromboplastin time prolonged 21.52 9.49 48 105795 6841 46573378
Product substitution issue 21.51 9.49 4 105839 15027 46565192
Clostridium test positive 21.49 9.49 24 105819 1880 46578339
Septic shock 21.41 9.49 213 105630 57680 46522539
Dermatitis bullous 21.39 9.49 51 105792 7592 46572627
Confabulation 21.39 9.49 11 105832 259 46579960
Cholestatic liver injury 21.32 9.49 25 105818 2065 46578154
Product use issue 21.00 9.49 127 105716 94517 46485702
Diabetes mellitus 20.93 9.49 52 105791 50013 46530206
Neutrophilic dermatosis 20.81 9.49 8 105835 91 46580128
Multiple sclerosis relapse 20.71 9.49 40 105803 42085 46538134
Potentiating drug interaction 20.49 9.49 34 105809 3889 46576330
Neurotransmitter level altered 20.37 9.49 4 105839 0 46580219
Renal vein compression 20.37 9.49 4 105839 0 46580219
Tendon laxity 20.37 9.49 4 105839 0 46580219
Hepatitis cholestatic 20.27 9.49 46 105797 6631 46573588
Gallbladder disorder 20.22 9.49 86 105757 17412 46562807
Rectal tube insertion 19.99 9.49 5 105838 10 46580209
Polyneuropathy 19.98 9.49 65 105778 11579 46568640
Bacteriuria 19.96 9.49 15 105828 702 46579517
Product deposit 19.79 9.49 9 105834 160 46580059
Enterovesical fistula 19.71 9.49 13 105830 493 46579726
Feeding intolerance 19.61 9.49 13 105830 497 46579722
Basal cell carcinoma 19.61 9.49 11 105832 20476 46559743
Female genital tract fistula 19.57 9.49 30 105813 3209 46577010
Hypoaesthesia 19.45 9.49 378 105465 118491 46461728
Acute febrile neutrophilic dermatosis 19.31 9.49 27 105816 2658 46577561
Rotator cuff syndrome 19.28 9.49 64 105779 11519 46568700
Osteonecrosis 19.20 9.49 18 105825 25726 46554493
Foetal exposure during pregnancy 19.08 9.49 25 105818 30722 46549497
Dysuria 18.98 9.49 118 105725 27715 46552504
Photosensitivity reaction 18.96 9.49 68 105775 12724 46567495
Cholecystitis acute 18.67 9.49 48 105795 7490 46572729
Head injury 18.64 9.49 17 105826 24619 46555600
Vanishing bile duct syndrome 18.54 9.49 14 105829 660 46579559
Hepatic enzyme increased 18.54 9.49 109 105734 81678 46498541
Respiratory arrest 18.53 9.49 30 105813 33786 46546433
Nervous system disorder 18.43 9.49 79 105764 16050 46564169
Tonsillar haemorrhage 18.31 9.49 9 105834 192 46580027
Cholelithiasis 18.23 9.49 150 105693 38531 46541688
Product administration error 18.22 9.49 11 105832 19670 46560549
Roseola 18.13 9.49 4 105839 3 46580216
Skin oedema 18.13 9.49 15 105828 808 46579411
Bradycardia 18.04 9.49 83 105760 66215 46514004
Infrequent bowel movements 18.02 9.49 17 105826 1091 46579128
Nephropathy toxic 17.98 9.49 47 105796 7407 46572812
Vulvovaginal swelling 17.96 9.49 12 105831 465 46579754
Long QT syndrome 17.87 9.49 28 105815 3052 46577167
Herpes zoster 17.86 9.49 86 105757 67786 46512433
Gastrointestinal infection 17.73 9.49 45 105798 6965 46573254
Hypotony of eye 17.71 9.49 8 105835 140 46580079
Crohn's disease 17.69 9.49 44 105799 6727 46573492
Sensory processing disorder 17.60 9.49 4 105839 4 46580215
Faecal volume decreased 17.55 9.49 8 105835 143 46580076
Rectal abscess 17.53 9.49 16 105827 984 46579235
Poisoning 17.49 9.49 5 105838 13989 46566230
Myopathy 17.48 9.49 52 105791 8829 46571390
Bronchitis 17.36 9.49 155 105688 105824 46474395
Sepsis 17.27 9.49 417 105426 135597 46444622
Staphylococcal scalded skin syndrome 17.21 9.49 8 105835 150 46580069
Skin injury 17.11 9.49 19 105824 1479 46578740
Leukocytosis 17.10 9.49 101 105742 23297 46556922
Hepatitis infectious mononucleosis 17.04 9.49 7 105836 96 46580123
Pancytopenia 16.93 9.49 279 105564 84779 46495440
Cerebrovascular accident 16.89 9.49 147 105696 100892 46479327
Intentional self-injury 16.76 9.49 18 105825 24148 46556071
Exercise tolerance decreased 16.73 9.49 34 105809 4543 46575676
Seroconversion test positive 16.72 9.49 5 105838 24 46580195
Phlebitis 16.64 9.49 40 105803 5986 46574233
Abscess 16.63 9.49 69 105774 13820 46566399
Disease progression 16.55 9.49 130 105713 91170 46489049
Abdominal pain lower 16.50 9.49 93 105750 21088 46559131
Infective aneurysm 16.45 9.49 11 105832 427 46579792
Blister 16.40 9.49 164 105679 44467 46535752
Cardiac failure 16.34 9.49 110 105733 79838 46500381
Skin candida 16.28 9.49 14 105829 796 46579423
Rash 16.26 9.49 975 104868 355537 46224682
Anhedonia 16.23 9.49 56 105787 10279 46569940
Vulvovaginal burning sensation 16.23 9.49 19 105824 1567 46578652
Hallucination 16.22 9.49 179 105664 49772 46530447
Pulmonary hypertension 16.15 9.49 36 105807 35957 46544262
Foreign body aspiration 16.13 9.49 8 105835 174 46580045
Road traffic accident 16.04 9.49 18 105825 23673 46556546
Acute myocardial infarction 15.96 9.49 30 105813 31894 46548325
Injection site hyperaesthesia 15.94 9.49 5 105838 29 46580190
Recall phenomenon 15.89 9.49 12 105831 566 46579653
Oesophageal spasm 15.82 9.49 21 105822 1968 46578251
Blood glucose increased 15.78 9.49 97 105746 71916 46508303
Burnout syndrome 15.53 9.49 8 105835 189 46580030
Toxic encephalopathy 15.51 9.49 35 105808 5027 46575192
Arthritis 15.49 9.49 107 105736 77209 46503010
Cystic fibrosis 15.43 9.49 29 105814 3659 46576560
Collagen disorder 15.42 9.49 8 105835 192 46580027
May-Thurner syndrome 15.39 9.49 5 105838 33 46580186
Hot flush 15.38 9.49 49 105794 43468 46536751
Cardiac arrest 15.34 9.49 131 105712 90268 46489951
Haemorrhagic vasculitis 15.32 9.49 6 105837 72 46580147
Influenza 15.31 9.49 129 105714 89141 46491078
Frequent bowel movements 15.31 9.49 63 105780 12569 46567650
Clitoral engorgement 15.28 9.49 3 105840 0 46580219
Somatic dysfunction 15.28 9.49 3 105840 0 46580219
Injection site joint erythema 15.28 9.49 3 105840 0 46580219
Dyspnoea 15.27 9.49 986 104857 514562 46065657
Nerve degeneration 15.25 9.49 6 105837 73 46580146
Renal injury 15.25 9.49 52 105791 9489 46570730
Toxic neuropathy 15.24 9.49 10 105833 376 46579843
Clostridium colitis 15.17 9.49 20 105823 1862 46578357
Purple glove syndrome 15.16 9.49 8 105835 199 46580020
Cholecystitis 15.12 9.49 69 105774 14397 46565822
Diabetic macroangiopathy 14.88 9.49 7 105836 135 46580084
Tongue geographic 14.82 9.49 6 105837 79 46580140
Haematuria 14.79 9.49 108 105735 26750 46553469
Limb immobilisation 14.79 9.49 5 105838 38 46580181
Arrhythmia 14.78 9.49 132 105711 34709 46545510
Chronic fatigue syndrome 14.74 9.49 15 105828 1056 46579163
Oxygen saturation decreased 14.72 9.49 94 105749 69070 46511149
Mucosal inflammation 14.70 9.49 144 105699 38832 46541387
Myoclonus 14.67 9.49 68 105775 14284 46565935
Dysaesthesia 14.62 9.49 26 105817 3145 46577074
Injection site streaking 14.56 9.49 5 105838 40 46580179
Post viral fatigue syndrome 14.56 9.49 7 105836 142 46580077
Norovirus test positive 14.51 9.49 7 105836 143 46580076
Ballismus 14.49 9.49 6 105837 84 46580135
Electrocardiogram QT prolonged 14.47 9.49 179 105664 51146 46529073
Abnormal palmar/plantar creases 14.46 9.49 5 105838 41 46580178
Biopsy colon abnormal 14.46 9.49 5 105838 41 46580178
Vulvovaginal pain 14.42 9.49 21 105822 2146 46578073
Small fibre neuropathy 14.38 9.49 7 105836 146 46580073
Fasciitis 14.36 9.49 11 105832 530 46579689
Bacteraemia 14.36 9.49 67 105776 14112 46566107
Somnolence 14.34 9.49 259 105584 156262 46423957
Haemolytic anaemia 14.31 9.49 52 105791 9790 46570429
Neoplasm progression 14.31 9.49 24 105819 26659 46553560
Crystal nephropathy 14.08 9.49 13 105830 812 46579407
Malignant melanoma 14.07 9.49 3 105840 10231 46569988
Neutropenic infection 13.99 9.49 15 105828 1123 46579096
Deficiency of bile secretion 13.97 9.49 4 105839 16 46580203
C-reactive protein decreased 13.94 9.49 12 105831 683 46579536
Blood creatinine increased 13.89 9.49 247 105596 76156 46504063
Infected fistula 13.88 9.49 6 105837 94 46580125
Escherichia urinary tract infection 13.73 9.49 53 105790 10270 46569949
Depersonalisation/derealisation disorder 13.64 9.49 14 105829 996 46579223
Red blood cell sedimentation rate abnormal 13.54 9.49 7 105836 13642 46566577
Hypertensive crisis 13.48 9.49 7 105836 13608 46566611
Overdose 13.46 9.49 157 105686 101822 46478397
Hyperpathia 13.41 9.49 4 105839 19 46580200
Vitreous floaters 13.41 9.49 33 105810 5012 46575207
Plantar fasciitis 13.40 9.49 23 105820 2705 46577514
Tuberculosis gastrointestinal 13.37 9.49 9 105834 353 46579866
Iatrogenic injury 13.27 9.49 13 105830 874 46579345
Walking disability 13.26 9.49 16 105827 1362 46578857
Sensory disturbance 13.19 9.49 59 105784 12208 46568011
Skin test positive 13.18 9.49 12 105831 736 46579483
Candida infection 13.16 9.49 91 105752 22149 46558070
Flushing 13.15 9.49 89 105754 64525 46515694
Haematoma 13.14 9.49 120 105723 31752 46548467
Restlessness 13.13 9.49 101 105742 25423 46554796
Underdose 13.09 9.49 15 105828 19543 46560676
Peripheral nerve injury 13.04 9.49 9 105834 368 46579851
Condition aggravated 13.02 9.49 440 105403 244612 46335607
Incorrect dose administered 13.01 9.49 56 105787 45494 46534725
Abdominal pain upper 12.99 9.49 426 105417 144879 46435340
Muscle tightness 12.97 9.49 52 105791 10253 46569966
Neuralgia 12.95 9.49 88 105755 21295 46558924
Deafness bilateral 12.86 9.49 15 105828 1232 46578987
Conjunctival hyperaemia 12.84 9.49 19 105824 1970 46578249
Factor XIII Inhibition 12.78 9.49 4 105839 23 46580196
Leukocyturia 12.55 9.49 13 105830 935 46579284
Eczema asteatotic 12.52 9.49 8 105835 287 46579932
Plasma cell myeloma 12.51 9.49 55 105788 44423 46535796
Burning mouth syndrome 12.40 9.49 9 105834 399 46579820
Metastases to kidney 12.39 9.49 7 105836 200 46580019
Pneumonia aspiration 12.31 9.49 34 105809 31571 46548648
Fatigue 12.30 9.49 1201 104642 607496 45972723
Spinal fracture 12.26 9.49 10 105833 15295 46564924
Eosinophilia 12.19 9.49 80 105763 19137 46561082
Bulimia nervosa 12.15 9.49 10 105833 535 46579684
Fluid retention 12.12 9.49 67 105776 50979 46529240
Perineal abscess 12.08 9.49 7 105836 210 46580009
Tenosynovitis 12.05 9.49 41 105802 7474 46572745
Muscle strength abnormal 11.99 9.49 3 105840 6 46580213
Staphylococcal sepsis 11.99 9.49 41 105802 7491 46572728
Kidney infection 11.96 9.49 72 105771 16717 46563502
Type IV hypersensitivity reaction 11.93 9.49 21 105822 2519 46577700
Gallbladder rupture 11.92 9.49 9 105834 424 46579795
Fear of death 11.91 9.49 13 105830 993 46579226
Sinusitis 11.80 9.49 215 105628 129553 46450666
Drug withdrawal syndrome 11.79 9.49 28 105815 27356 46552863
Epicondylitis 11.76 9.49 17 105826 1725 46578494
Mast cell activation syndrome 11.76 9.49 7 105836 221 46579998
Medical device site pain 11.73 9.49 7 105836 222 46579997
Gallbladder injury 11.69 9.49 15 105828 1359 46578860
Device malfunction 11.66 9.49 8 105835 13366 46566853
Mitochondrial enzyme deficiency 11.65 9.49 4 105839 32 46580187
Quadriparesis 11.60 9.49 17 105826 1747 46578472
Mycobacterium chelonae infection 11.60 9.49 9 105834 442 46579777
Hypotension 11.57 9.49 421 105422 232168 46348051
Nervousness 11.57 9.49 30 105813 28445 46551774
Sense of oppression 11.56 9.49 13 105830 1026 46579193
Depressed level of consciousness 11.53 9.49 62 105781 47507 46532712
Henoch-Schonlein purpura 11.53 9.49 13 105830 1029 46579190
Toxic shock syndrome 11.48 9.49 9 105834 449 46579770
Paraesthesia oral 11.46 9.49 55 105788 11718 46568501
Vulvovaginal candidiasis 11.46 9.49 21 105822 2600 46577619
Mineral metabolism disorder 11.40 9.49 3 105840 8 46580211
Ligament rupture 11.39 9.49 21 105822 2612 46577607
Urethral pain 11.34 9.49 6 105837 150 46580069
Nasal polyps 11.34 9.49 19 105824 2191 46578028
Intrauterine infection 11.20 9.49 5 105838 85 46580134
Diarrhoea haemorrhagic 11.20 9.49 40 105803 7469 46572750
Transient ischaemic attack 11.18 9.49 41 105802 34862 46545357
Blood disorder 11.12 9.49 33 105810 5594 46574625
Extremity necrosis 11.12 9.49 16 105827 1617 46578602
Hallucinations, mixed 11.11 9.49 26 105817 3823 46576396
Myocardial infarction 11.07 9.49 155 105688 97373 46482846
Extraocular muscle paresis 10.99 9.49 6 105837 160 46580059
Thyroxine free decreased 10.92 9.49 9 105834 482 46579737
Muscle rupture 10.92 9.49 18 105825 2047 46578172
Vein discolouration 10.92 9.49 6 105837 162 46580057
Complex regional pain syndrome 10.92 9.49 18 105825 2048 46578171
Cytokine release syndrome 10.91 9.49 35 105808 6188 46574031
Grip strength decreased 10.90 9.49 3 105840 8603 46571616
Urticaria 10.89 9.49 347 105496 117545 46462674
Visual impairment 10.87 9.49 212 105631 66477 46513742
Ureteric injury 10.87 9.49 4 105839 40 46580179
Myositis 10.86 9.49 41 105802 7863 46572356
Acid base balance abnormal 10.67 9.49 7 105836 263 46579956
Abdominal tenderness 10.65 9.49 38 105805 7090 46573129
Injection site urticaria 10.65 9.49 7 105836 11960 46568259
Fracture 10.63 9.49 13 105830 16458 46563761
Staphylococcal infection 10.63 9.49 126 105717 35645 46544574
Gastroenteritis clostridial 10.61 9.49 9 105834 502 46579717
Peritoneal adhesions 10.60 9.49 7 105836 266 46579953
Dermatitis exfoliative generalised 10.56 9.49 22 105821 2991 46577228
Plasmapheresis 10.53 9.49 7 105836 269 46579950
Injection site thrombosis 10.51 9.49 5 105838 99 46580120
Hormone level abnormal 10.46 9.49 18 105825 2120 46578099
Skin burning sensation 10.44 9.49 50 105793 10642 46569577
Cystitis interstitial 10.41 9.49 14 105829 1328 46578891
Abscess intestinal 10.38 9.49 14 105829 1332 46578887
Exfoliative rash 10.36 9.49 20 105823 2575 46577644
Paraneoplastic syndrome 10.27 9.49 9 105834 525 46579694
Helicobacter infection 10.26 9.49 7 105836 11729 46568490
Hyperkalaemia 10.25 9.49 70 105773 50639 46529580
Scar excision 10.22 9.49 4 105839 48 46580171
Rash erythematous 10.21 9.49 121 105722 34229 46545990
Thyroxine increased 10.18 9.49 9 105834 531 46579688
Single functional kidney 10.16 9.49 5 105838 107 46580112
Infusion site reaction 10.15 9.49 16 105827 1753 46578466
Device related infection 10.13 9.49 82 105761 20959 46559260
Chronic graft versus host disease in eye 10.10 9.49 3 105840 14 46580205
Right ventricular failure 10.07 9.49 13 105830 16080 46564139
Oophoritis 10.07 9.49 4 105839 50 46580169
Immune effector cell-associated neurotoxicity syndrome 10.07 9.49 10 105833 684 46579535
Clostridium bacteraemia 10.03 9.49 6 105837 191 46580028
Osteonecrosis of jaw 10.00 9.49 42 105801 34360 46545859
Enterocutaneous fistula 9.97 9.49 13 105830 1197 46579022
Face oedema 9.97 9.49 76 105767 19077 46561142
Intestinal dilatation 9.91 9.49 15 105828 1587 46578632
Glaucoma 9.82 9.49 13 105830 15908 46564311
Thrombotic thrombocytopenic purpura 9.79 9.49 25 105818 3885 46576334
External ear inflammation 9.77 9.49 3 105840 16 46580203
Ligament disorder 9.73 9.49 8 105835 427 46579792
Rectal tenesmus 9.73 9.49 8 105835 427 46579792
Vulvovaginal inflammation 9.73 9.49 9 105834 563 46579656
Refractory anaemia with an excess of blasts 9.73 9.49 8 105835 427 46579792
Pre-eclampsia 9.73 9.49 3 105840 7991 46572228
Injection site rash 9.67 9.49 13 105830 15800 46564419
Faeces soft 9.64 9.49 23 105820 3425 46576794
Nephrolithiasis 9.63 9.49 116 105727 32935 46547284
Loss of consciousness 9.63 9.49 180 105663 108058 46472161
Mucosal hyperaemia 9.62 9.49 3 105840 17 46580202
Connective tissue inflammation 9.60 9.49 4 105839 57 46580162
Product complaint 9.58 9.49 8 105835 12093 46568126
Human ehrlichiosis 9.58 9.49 6 105837 208 46580011
Cholesterosis 9.57 9.49 8 105835 437 46579782
Thrombocytosis 9.57 9.49 29 105814 4973 46575246
Purpura fulminans 9.53 9.49 4 105839 58 46580161
Abscess fungal 9.53 9.49 4 105839 58 46580161
Concomitant disease aggravated 9.52 9.49 3 105840 7879 46572340

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tendon pain 637.09 9.91 244 80233 2283 29869718
Tendonitis 592.03 9.91 330 80147 7706 29864295
Tendon rupture 429.39 9.91 256 80221 6808 29865193
Tendon disorder 257.36 9.91 125 80352 2171 29869830
Death 202.20 9.91 411 80066 356872 29515129
Pathogen resistance 187.76 9.91 166 80311 8244 29863757
Tendon discomfort 161.31 9.91 49 80428 204 29871797
Drug abuse 152.76 9.91 20 80457 82052 29789949
Completed suicide 144.24 9.91 44 80433 99448 29772553
Toxic epidermal necrolysis 143.03 9.91 207 80270 17733 29854268
Drug hypersensitivity 127.01 9.91 439 80038 68080 29803921
Drug interaction 126.61 9.91 943 79534 198625 29673376
Clostridium difficile colitis 113.16 9.91 155 80322 12613 29859388
Myocardial infarction 111.44 9.91 104 80373 125521 29746480
Drug resistance 102.91 9.91 190 80287 19943 29852058
Joint noise 101.80 9.91 43 80434 529 29871472
Tinnitus 84.96 9.91 154 80323 15934 29856067
Drug reaction with eosinophilia and systemic symptoms 78.60 9.91 210 80267 28278 29843723
Septic shock 78.59 9.91 359 80118 63248 29808753
Intentional overdose 72.77 9.91 12 80465 41469 29830532
Tubulointerstitial nephritis 69.97 9.91 151 80326 17740 29854261
Neuralgia 69.57 9.91 111 80366 10355 29861646
Product dose omission issue 68.86 9.91 87 80390 91544 29780457
Overdose 68.82 9.91 75 80402 84262 29787739
Fall 68.80 9.91 254 80223 181618 29690383
Cerebrovascular accident 68.37 9.91 74 80403 83403 29788598
Paraesthesia 68.12 9.91 308 80169 54019 29817982
Myalgia 67.73 9.91 394 80083 76273 29795728
Toxicity to various agents 62.80 9.91 254 80223 176929 29695072
Urinary tract infection 62.77 9.91 375 80102 73284 29798717
Hyperacusis 61.98 9.91 31 80446 575 29871426
Panic attack 61.77 9.91 95 80382 8586 29863415
Choroiditis 60.67 9.91 34 80443 801 29871200
Torsade de pointes 60.28 9.91 85 80392 7105 29864896
Pseudomonas infection 58.76 9.91 103 80374 10379 29861622
Stevens-Johnson syndrome 58.44 9.91 139 80338 17417 29854584
Prostatitis 58.40 9.91 69 80408 4838 29867163
Arthralgia 57.78 9.91 588 79889 135203 29736798
Foetal exposure during pregnancy 57.72 9.91 14 80463 36857 29835144
Pruritus genital 57.06 9.91 27 80450 441 29871560
Pseudomembranous colitis 55 9.91 52 80425 2816 29869185
Muscle twitching 54.90 9.91 87 80390 8068 29863933
Dysbiosis 54.51 9.91 25 80452 379 29871622
Rheumatoid arthritis 53.19 9.91 22 80455 41175 29830826
Eye pain 48.99 9.91 102 80375 11687 29860314
Clostridium difficile infection 48.31 9.91 121 80356 15662 29856339
Solar lentigo 45.75 9.91 21 80456 319 29871682
Muscle rupture 45.61 9.91 41 80436 2080 29869921
Cardiac failure congestive 45.00 9.91 100 80377 84307 29787694
Dysplastic naevus 44.60 9.91 21 80456 339 29871662
Burning sensation 43.98 9.91 120 80357 16354 29855647
Acute generalised exanthematous pustulosis 43.76 9.91 67 80410 6031 29865970
Fistula 43.60 9.91 61 80416 5061 29866940
Abdominal abscess 42.29 9.91 53 80424 3951 29868050
Pyrexia 42.26 9.91 1062 79415 293427 29578574
Endophthalmitis 41.53 9.91 49 80428 3431 29868570
Urosepsis 41.30 9.91 90 80387 10642 29861359
Wrong technique in product usage process 41.26 9.91 16 80461 31139 29840862
Photodermatosis 40.83 9.91 21 80456 414 29871587
Psoriasis 40.28 9.91 33 80444 42473 29829528
Factor V inhibition 39.80 9.91 16 80461 172 29871829
Acute myocardial infarction 38.98 9.91 51 80426 52888 29819113
Intentional product misuse 38.01 9.91 23 80454 34644 29837357
Night sweats 37.96 9.91 105 80372 14423 29857578
Impaired work ability 37.71 9.91 60 80417 5583 29866418
Orchitis 37.19 9.91 32 80445 1531 29870470
Tendon injury 37.11 9.91 25 80452 825 29871176
Linear IgA disease 36.51 9.91 32 80445 1570 29870431
Crohn's disease 35.82 9.91 51 80426 4301 29867700
Multiple organ dysfunction syndrome 35.64 9.91 292 80185 63195 29808806
Diastasis recti abdominis 35.15 9.91 9 80468 16 29871985
Musculoskeletal injury 33.89 9.91 13 80464 122 29871879
Aortic valve prolapse 33.37 9.91 8 80469 9 29871992
Clostridium test positive 33.32 9.91 34 80443 2022 29869979
Aeromonas infection 33.29 9.91 16 80461 271 29871730
Plantar fasciitis 32.94 9.91 24 80453 900 29871101
Suicide attempt 32.93 9.91 30 80447 36667 29835334
Blood glucose increased 32.70 9.91 73 80404 61457 29810544
Ependymoma 32.64 9.91 11 80466 68 29871933
Yellow fever 31.97 9.91 7 80470 3 29871998
Febrile neutropenia 31.97 9.91 432 80045 106261 29765740
Candida infection 31.58 9.91 102 80375 15260 29856741
Escherichia infection 30.91 9.91 59 80418 6346 29865655
Anuria 30.44 9.91 78 80399 10238 29861763
Pouchitis 30.32 9.91 20 80457 637 29871364
Renal tubular necrosis 30.22 9.91 100 80377 15151 29856850
Acute kidney injury 30.13 9.91 955 79522 272887 29599114
Fixed eruption 29.73 9.91 25 80452 1159 29870842
Undersensing 29.62 9.91 7 80470 7 29871994
Chest pain 29.46 9.91 190 80287 117437 29754564
Hypertension 29.40 9.91 198 80279 121156 29750845
Injection site pain 29.38 9.91 23 80454 30287 29841714
Aspergillus infection 28.87 9.91 76 80401 10138 29861863
Infective pulmonary exacerbation of cystic fibrosis 28.66 9.91 68 80409 8504 29863497
Sphingomonas paucimobilis infection 28.63 9.91 9 80468 43 29871958
Connective tissue disorder 28.23 9.91 13 80464 199 29871802
Vitreous floaters 28.16 9.91 39 80438 3205 29868796
Dyspnoea 28.04 9.91 682 79795 332613 29539388
Neuropathy peripheral 27.94 9.91 301 80176 70174 29801827
Hypnagogic hallucination 27.87 9.91 8 80469 26 29871975
Asthma 27.51 9.91 34 80443 36140 29835861
Ligament pain 27.14 9.91 7 80470 13 29871988
Premature baby 26.79 9.91 6 80471 16685 29855316
Rectal abscess 26.57 9.91 21 80456 891 29871110
Penis injury 26.34 9.91 13 80464 234 29871767
Weight increased 26.10 9.91 108 80369 74805 29797196
Cutaneous vasculitis 26.03 9.91 36 80441 2955 29869046
Pelvic abscess 25.77 9.91 21 80456 931 29871070
Abscess intestinal 25.74 9.91 25 80452 1400 29870601
Coronary artery disease 25.59 9.91 60 80417 49652 29822349
Palpitations 25.49 9.91 166 80311 33407 29838594
Walking aid user 25.42 9.91 25 80452 1422 29870579
Enterococcal infection 25.11 9.91 63 80414 8161 29863840
Anal abscess 24.84 9.91 47 80430 5022 29866979
Chest injury 24.77 9.91 24 80453 1340 29870661
Yellow fever vaccine-associated viscerotropic disease 24.61 9.91 5 80472 0 29872001
Sensory processing disorder 24.61 9.91 5 80472 0 29872001
Abscess 24.53 9.91 71 80406 10007 29861994
Anal fissure 24.22 9.91 31 80446 2360 29869641
Anxiety 24.14 9.91 357 80120 89514 29782487
Pulmonary embolism 24.01 9.91 118 80359 78017 29793984
Cardiac failure 23.93 9.91 129 80348 83289 29788712
Chronic fatigue syndrome 23.71 9.91 13 80464 293 29871708
Trichosporon infection 23.36 9.91 17 80460 636 29871365
Photosensitivity reaction 23.31 9.91 68 80409 9626 29862375
Musculoskeletal discomfort 23.30 9.91 52 80425 6248 29865753
Intraocular pressure increased 23.29 9.91 46 80431 5074 29866927
Bradycardia 23.11 9.91 94 80383 65432 29806569
Geotrichum infection 23.10 9.91 15 80462 465 29871536
Corneal deposits 22.96 9.91 11 80466 185 29871816
Impaired quality of life 22.60 9.91 24 80453 1495 29870506
Therapeutic product effect incomplete 22.52 9.91 35 80442 33799 29838202
Urinary tract obstruction 22.50 9.91 36 80441 3365 29868636
Cystitis 22.35 9.91 61 80416 8313 29863688
Cardio-respiratory arrest 22.29 9.91 79 80398 57227 29814774
Oxidative stress 22.17 9.91 7 80470 34 29871967
Condition aggravated 22.04 9.91 505 79972 137361 29734640
Myosclerosis 22.04 9.91 9 80468 101 29871900
Penile haemorrhage 22.03 9.91 16 80461 597 29871404
Phlebitis infective 22.02 9.91 10 80467 148 29871853
Pain in extremity 21.95 9.91 417 80060 109804 29762197
Blood pressure increased 21.88 9.91 109 80368 71819 29800182
Nosocomial infection 21.59 9.91 21 80456 1178 29870823
Diabetic ketoacidosis 21.51 9.91 8 80469 15978 29856023
Ear pain 21.49 9.91 41 80436 4409 29867592
Abdominal pain 21.41 9.91 496 79981 135158 29736843
Intestinal stenosis 21.38 9.91 26 80451 1879 29870122
Product quality issue 21.22 9.91 12 80465 18762 29853239
Dermatitis bullous 21.04 9.91 49 80428 6055 29865946
Gastrointestinal inflammation 20.84 9.91 32 80445 2887 29869114
Clostridial infection 20.81 9.91 36 80441 3589 29868412
Acinetobacter infection 20.69 9.91 19 80458 991 29871010
Infective aneurysm 20.57 9.91 13 80464 384 29871617
Subacute cutaneous lupus erythematosus 20.57 9.91 16 80461 663 29871338
Ischaemic stroke 20.51 9.91 9 80468 16266 29855735
Chronic obstructive pulmonary disease 20.43 9.91 60 80417 46066 29825935
Otorrhoea 20.39 9.91 14 80463 477 29871524
Diabetes mellitus 20.39 9.91 52 80425 41813 29830188
Lumbosacral plexus injury 20.35 9.91 6 80471 22 29871979
Painful respiration 20.27 9.91 21 80456 1271 29870730
Hyphaema 20.25 9.91 13 80464 395 29871606
Chronic gastrointestinal bleeding 20.06 9.91 11 80466 248 29871753
Prolapse 19.69 9.91 4 80473 0 29872001
Yellow fever vaccine-associated neurotropic disease 19.69 9.91 4 80473 0 29872001
Posterior tibial tendon dysfunction 19.69 9.91 4 80473 0 29872001
Sopor 19.68 9.91 3 80474 10988 29861013
Anal fistula 19.59 9.91 37 80440 3949 29868052
Enterocutaneous fistula 19.51 9.91 16 80461 716 29871285
Megacolon 19.22 9.91 23 80454 1634 29870367
Angina pectoris 19.20 9.91 31 80446 29487 29842514
Cardiac disorder 19.08 9.91 50 80427 39843 29832158
Food intolerance 19.04 9.91 19 80458 1100 29870901
Neuroleptic malignant syndrome 19.02 9.91 10 80467 16285 29855716
Weight bearing difficulty 18.99 9.91 17 80460 858 29871143
Rash erythematous 18.90 9.91 114 80363 22338 29849663
Septic embolus 18.81 9.91 19 80458 1116 29870885
Hospitalisation 18.67 9.91 59 80418 44260 29827741
Gluten sensitivity 18.54 9.91 6 80471 32 29871969
Colitis 18.51 9.91 144 80333 30676 29841325
Interstitial lung disease 18.43 9.91 91 80386 60106 29811895
Myocardial haemorrhage 18.39 9.91 6 80471 33 29871968
Thrombotic thrombocytopenic purpura 18.35 9.91 33 80444 3392 29868609
Catatonia 18.32 9.91 38 80439 4342 29867659
Intestinal fistula 18.29 9.91 16 80461 783 29871218
Dyslexia 18.29 9.91 9 80468 161 29871840
Defaecation urgency 18.15 9.91 21 80456 1440 29870561
Anxiety disorder 18.11 9.91 21 80456 1443 29870558
Henoch-Schonlein purpura 17.96 9.91 21 80456 1456 29870545
Bacteraemia 17.85 9.91 86 80391 15474 29856527
Intentional self-injury 17.83 9.91 7 80470 13525 29858476
Cystic fibrosis 17.77 9.91 26 80451 2248 29869753
Eosinophilia 17.70 9.91 111 80366 22049 29849952
Visual impairment 17.61 9.91 141 80336 30297 29841704
Mental fatigue 17.43 9.91 7 80470 75 29871926
Muscle atrophy 17.43 9.91 48 80429 6576 29865425
Sacroiliitis 17.27 9.91 16 80461 844 29871157
Rash morbilliform 17.27 9.91 27 80450 2475 29869526
Muscle tightness 17.25 9.91 38 80439 4525 29867476
Bronchopulmonary aspergillosis 17.18 9.91 72 80405 12212 29859789
Spinal muscular atrophy 17.16 9.91 9 80468 185 29871816
Rash maculo-papular 17.10 9.91 122 80355 25296 29846705
Pseudoporphyria 17.03 9.91 10 80467 258 29871743
Respiratory arrest 16.98 9.91 33 80444 29225 29842776
Dysuria 16.83 9.91 111 80366 22430 29849571
Failure to suspend medication 16.80 9.91 7 80470 83 29871918
Drug intolerance 16.58 9.91 64 80413 45227 29826774
Magnesium deficiency 16.58 9.91 7 80470 86 29871915
Malignant neoplasm progression 16.48 9.91 120 80357 72167 29799834
Nasopharyngitis 16.32 9.91 92 80385 58757 29813244
Muscle fatigue 16.29 9.91 18 80459 1173 29870828
Ligament rupture 16.28 9.91 16 80461 909 29871092
Graft versus host disease 16.20 9.91 62 80415 10088 29861913
Sleep disorder 16.18 9.91 117 80360 24362 29847639
Irritability 16.16 9.91 23 80454 23027 29848974
Corneal opacity 16.16 9.91 13 80464 566 29871435
Metastases to liver 16.08 9.91 6 80471 11959 29860042
Haematospermia 16.04 9.91 11 80466 374 29871627
Blood creatine phosphokinase increased 16.03 9.91 62 80415 43786 29828215
Pyelonephritis 15.98 9.91 41 80436 5385 29866616
Cerebral infarction 15.96 9.91 29 80448 26344 29845657
Hepatitis cholestatic 15.93 9.91 52 80425 7820 29864181
Cardiac arrest 15.89 9.91 166 80311 92684 29779317
Joint stiffness 15.62 9.91 58 80419 9303 29862698
COVID-19 15.58 9.91 15 80462 17863 29854138
Fluorosis 15.58 9.91 6 80471 57 29871944
Coma 15.57 9.91 56 80421 40393 29831608
Deep vein thrombosis 15.50 9.91 97 80380 60404 29811597
Multiple-drug resistance 15.33 9.91 28 80449 2913 29869088
Angina bullosa haemorrhagica 15.31 9.91 6 80471 60 29871941
Systemic candida 15.28 9.91 27 80450 2737 29869264
Cogwheel rigidity 15.25 9.91 17 80460 1119 29870882
Increased viscosity of bronchial secretion 15.23 9.91 9 80468 235 29871766
Skin injury 15.20 9.91 16 80461 987 29871014
Hypoaesthesia 15.17 9.91 217 80260 54013 29817988
Eye infection fungal 15.12 9.91 10 80467 320 29871681
Rash 14.92 9.91 644 79833 191245 29680756
Gingival recession 14.90 9.91 11 80466 421 29871580
Stenotrophomonas infection 14.82 9.91 20 80457 1604 29870397
Toxic encephalopathy 14.80 9.91 36 80441 4573 29867428
Urine viscosity increased 14.77 9.91 3 80474 0 29872001
Nail bed inflammation 14.77 9.91 8 80469 176 29871825
Uveitis 14.72 9.91 40 80437 5437 29866564
Epistaxis 14.60 9.91 83 80394 52898 29819103
Venoocclusive liver disease 14.59 9.91 45 80432 6568 29865433
Ligament injury 14.58 9.91 10 80467 340 29871661
Loss of proprioception 14.54 9.91 9 80468 256 29871745
Mastoiditis 14.54 9.91 13 80464 655 29871346
Necrotising fasciitis 14.51 9.91 30 80447 3419 29868582
Aortic aneurysm 14.49 9.91 44 80433 6369 29865632
Pruritus 14.49 9.91 418 80059 117786 29754215
Tenderness 14.45 9.91 41 80436 5714 29866287
Kounis syndrome 14.35 9.91 20 80457 1653 29870348
Treatment noncompliance 14.21 9.91 29 80448 25224 29846777
Drug dependence 14.20 9.91 22 80455 21273 29850728
Sepsis 14.11 9.91 503 79974 145892 29726109
Plasma cell myeloma 14.07 9.91 85 80392 53377 29818624
Inguinal mass 13.95 9.91 5 80472 38 29871963
Drug ineffective for unapproved indication 13.85 9.91 62 80415 10818 29861183
Somnolence 13.85 9.91 180 80297 96583 29775418
Seizure 13.79 9.91 184 80293 98291 29773710
Crystal nephropathy 13.70 9.91 10 80467 376 29871625
Pulmonary arterial hypertension 13.66 9.91 4 80473 9297 29862704
Mycobacterium ulcerans infection 13.52 9.91 5 80472 42 29871959
Pulmonary valve disease 13.51 9.91 6 80471 84 29871917
Joint instability 13.49 9.91 10 80467 385 29871616
Drug level increased 13.47 9.91 90 80387 18264 29853737
Hyperkalaemia 13.45 9.91 113 80364 65897 29806104
Stomatococcal infection 13.43 9.91 7 80470 142 29871859
Underdose 13.38 9.91 8 80469 12133 29859868
Staphylococcal infection 13.35 9.91 132 80345 30092 29841909
Bladder spasm 13.29 9.91 14 80463 864 29871137
Epididymitis 13.27 9.91 23 80454 2296 29869705
Poisoning 13.26 9.91 7 80470 11375 29860626
Subdural haematoma 13.23 9.91 19 80458 18953 29853048
Endocarditis candida 13.20 9.91 6 80471 89 29871912
Leukocyturia 13.13 9.91 11 80466 507 29871494
Blood triglycerides increased 13.13 9.91 11 80466 14006 29857995
Withdrawal syndrome 12.99 9.91 7 80470 11243 29860758
Escherichia urinary tract infection 12.93 9.91 26 80451 2906 29869095
Meningitis 12.85 9.91 34 80443 4548 29867453
Lung neoplasm malignant 12.84 9.91 13 80464 15119 29856882
Coronary artery occlusion 12.80 9.91 7 80470 11150 29860851
Sputum increased 12.76 9.91 20 80457 1837 29870164
Roseolovirus test positive 12.74 9.91 6 80471 97 29871904
Vertebral artery hypoplasia 12.70 9.91 3 80474 3 29871998
Perineurial cyst 12.70 9.91 3 80474 3 29871998
Mucosal hyperaemia 12.70 9.91 3 80474 3 29871998
Post infection glomerulonephritis 12.70 9.91 3 80474 3 29871998
Pudendal canal syndrome 12.70 9.91 3 80474 3 29871998
Musculoskeletal pain 12.65 9.91 133 80344 30807 29841194
Osteonecrosis of jaw 12.64 9.91 19 80458 18599 29853402
Klebsiella infection 12.62 9.91 44 80433 6843 29865158
Polyneuropathy 12.60 9.91 64 80413 11759 29860242
Fungaemia 12.60 9.91 22 80455 2209 29869792
Vanishing bile duct syndrome 12.60 9.91 12 80465 656 29871345
Febrile bone marrow aplasia 12.55 9.91 49 80428 8048 29863953
Pseudomonal sepsis 12.51 9.91 26 80451 2974 29869027
Cervicobrachial syndrome 12.46 9.91 9 80468 333 29871668
Generalised oedema 12.44 9.91 64 80413 11821 29860180
Hepatic infarction 12.34 9.91 7 80470 169 29871832
Sensory disturbance 12.32 9.91 39 80438 5772 29866229
Oligoarthritis 12.25 9.91 5 80472 56 29871945
Cough 12.24 9.91 251 80226 125391 29746610
Scrotal pain 12.23 9.91 13 80464 811 29871190
Fluid retention 12.21 9.91 31 80446 24967 29847034
Accidental exposure to product 12.12 9.91 6 80471 10109 29861892
Breast inflammation 12.11 9.91 4 80473 23 29871978
Incorrect dose administered 12.10 9.91 44 80433 31642 29840359
Rotator cuff syndrome 12.10 9.91 37 80440 5376 29866625
Therapeutic response decreased 12.04 9.91 30 80447 24319 29847682
Resting tremor 12.02 9.91 11 80466 571 29871430
Head discomfort 12.00 9.91 25 80452 2865 29869136
Jaundice cholestatic 11.99 9.91 33 80444 4518 29867483
Ligament disorder 11.96 9.91 6 80471 112 29871889
Electrocardiogram QT prolonged 11.93 9.91 148 80329 35687 29836314
Labelled drug-drug interaction medication error 11.91 9.91 58 80419 10480 29861521
Flushing 11.91 9.91 40 80437 29452 29842549
Tenosynovitis 11.88 9.91 28 80449 3487 29868514
Glomerular filtration rate decreased 11.82 9.91 8 80469 11354 29860647
Visual acuity reduced 11.81 9.91 78 80399 15768 29856233
Retinopathy hypertensive 11.72 9.91 8 80469 270 29871731
Inflammation 11.65 9.91 100 80377 21926 29850075
Nephritis allergic 11.63 9.91 9 80468 370 29871631
Lip erosion 11.60 9.91 11 80466 598 29871403
Screaming 11.55 9.91 16 80461 1315 29870686
Anal stenosis 11.54 9.91 6 80471 121 29871880
Throat tightness 11.53 9.91 44 80433 7148 29864853
Expanded disability status scale score increased 11.51 9.91 7 80470 193 29871808
Product administration error 11.48 9.91 13 80464 14364 29857637
Arteriosclerosis coronary artery 11.45 9.91 8 80469 11168 29860833
Myocardial ischaemia 11.44 9.91 18 80459 17299 29854702
Neuropsychiatric symptoms 11.44 9.91 10 80467 489 29871512
Tooth injury 11.43 9.91 12 80465 738 29871263
Idiosyncratic drug reaction 11.42 9.91 10 80467 490 29871511
Urinary retention 11.41 9.91 137 80340 32780 29839221
Aspartate aminotransferase 11.33 9.91 6 80471 126 29871875
Walking disability 11.31 9.91 12 80465 747 29871254
Renal abscess 11.22 9.91 7 80470 202 29871799
Eye excision 11.21 9.91 4 80473 30 29871971
Food allergy 11.19 9.91 13 80464 895 29871106
Jaundice 11.17 9.91 135 80342 32351 29839650
Microbiology test abnormal 11.17 9.91 3 80474 7 29871994
Glutathione decreased 11.17 9.91 3 80474 7 29871994
Blood catecholamines decreased 11.17 9.91 3 80474 7 29871994
Hepatic amoebiasis 11.13 9.91 5 80472 72 29871929
Angina unstable 11.12 9.91 10 80467 12300 29859701
Aortic aneurysm rupture 11.10 9.91 14 80463 1050 29870951
Abdominal pain lower 11.10 9.91 50 80427 8748 29863253
Peripheral sensory neuropathy 11.07 9.91 38 80439 5863 29866138
Injection site bruising 11.07 9.91 3 80474 7335 29864666
Hepatocellular carcinoma 11.07 9.91 6 80471 9604 29862397
Prothrombin time shortened 11.04 9.91 17 80460 1538 29870463
Hyperoxaluria 11.03 9.91 6 80471 133 29871868
Neutropenia 11.02 9.91 436 80041 128104 29743897
Aortic intramural haematoma 10.99 9.91 4 80473 32 29871969
Oesophageal mucosa erythema 10.99 9.91 4 80473 32 29871969
Hyperthyroidism 10.99 9.91 4 80473 8094 29863907
Hair colour changes 10.95 9.91 17 80460 1548 29870453
Corynebacterium infection 10.93 9.91 9 80468 405 29871596
Hyperglycaemia 10.89 9.91 53 80424 35147 29836854
Fear of death 10.88 9.91 11 80466 647 29871354
Lactic acidosis 10.86 9.91 45 80432 31168 29840833
Pneumonia pseudomonal 10.79 9.91 27 80450 3491 29868510
Tongue coated 10.78 9.91 7 80470 217 29871784
Arteriosclerosis 10.78 9.91 8 80469 10825 29861176
Nervous system disorder 10.77 9.91 66 80411 13003 29858998
Guillain-Barre syndrome 10.67 9.91 34 80443 5049 29866952
Colour blindness 10.67 9.91 7 80470 221 29871780
Cholestatic liver injury 10.66 9.91 17 80460 1584 29870417
Stenotrophomonas test positive 10.62 9.91 8 80469 316 29871685
Keratitis fungal 10.60 9.91 5 80472 81 29871920
Inappropriate schedule of product administration 10.54 9.91 63 80414 39665 29832336
Vasculitis 10.53 9.91 46 80431 7944 29864057
Yawning 10.49 9.91 10 80467 547 29871454
Alcohol intolerance 10.45 9.91 9 80468 431 29871570
Osteonecrosis 10.44 9.91 17 80460 16118 29855883
Enterocolitis haemorrhagic 10.42 9.91 13 80464 964 29871037
Infusion related reaction 10.41 9.91 65 80412 40499 29831502
Prescribed overdose 10.37 9.91 5 80472 8556 29863445
Obesity 10.36 9.91 5 80472 8550 29863451
Pneumoperitoneum 10.36 9.91 17 80460 1623 29870378
Haemolytic uraemic syndrome 10.36 9.91 19 80458 1983 29870018
Chondritis 10.35 9.91 6 80471 151 29871850
Hypofibrinogenaemia 10.32 9.91 17 80460 1628 29870373
Protein total abnormal 10.29 9.91 8 80469 331 29871670
Agranulocytosis 10.26 9.91 97 80380 21845 29850156
Atrioventricular block complete 10.20 9.91 5 80472 8472 29863529
Blood urine 10.19 9.91 9 80468 446 29871555
Hyperinsulinaemia 10.18 9.91 5 80472 89 29871912
Nutritional condition abnormal 10.11 9.91 9 80468 451 29871550
Enterocolitis bacterial 10.10 9.91 7 80470 242 29871759
Peritoneal neoplasm 10.03 9.91 4 80473 42 29871959
Anal inflammation 10.03 9.91 8 80469 344 29871657
Necrotising retinitis 9.99 9.91 11 80466 714 29871287
Penile blister 9.98 9.91 5 80472 93 29871908
Blood cholesterol increased 9.97 9.91 19 80458 16951 29855050
Skin depigmentation 9.97 9.91 8 80469 347 29871654
Flavobacterium infection 9.94 9.91 5 80472 94 29871907
Gynaecomastia 9.93 9.91 5 80472 8346 29863655
Oliguria 9.93 9.91 43 80434 7396 29864605

Pharmacologic Action:

SourceCodeDescription
ATC J01MA02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
ATC S01AE03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Fluoroquinolones
ATC S02AA15 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA07 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
ATC J01RA10 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J01RA11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J01RA12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
FDA CS M0023650 Quinolones
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D065609 Cytochrome P-450 CYP1A2 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D059005 Topoisomerase II Inhibitors
FDA EPC N0000175937 Quinolone Antimicrobial
CHEBI has role CHEBI:35441 anti-infective drugs
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:50750 inhibitors of type ii topoisomerase
CHEBI has role CHEBI:53559 topoisomerase iv inhibitors
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:59517 dna synthesis inhibitors
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Typhoid fever indication 4834000 DOID:13258
Septicemia due to Escherichia coli indication 9323009
Prostatitis indication 9713002 DOID:14654
Infection due to Pseudomonas aeruginosa indication 11218009
Enteric campylobacteriosis indication 18081009
Infectious diarrheal disease indication 19213003 DOID:13250
Infection of skin AND/OR subcutaneous tissue indication 19824006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Acute gonococcal urethritis indication 29864006
Acute bacterial peritonitis indication 31860008
Pneumonia due to Streptococcus indication 34020007
Shigellosis indication 36188001
Cystitis indication 38822007 DOID:1679
Pneumonia due to Pseudomonas indication 41381004
Lower respiratory tract infection indication 50417007
Pneumonia due to Escherichia coli indication 51530003
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Acute maxillary sinusitis indication 68272006 DOID:2050
Haemophilus influenzae pneumonia indication 70036007
Infection due to Escherichia coli indication 71057007
Rhinoscleroma indication 72409005 DOID:11336
Abdominal abscess indication 75100008
Acute bacterial sinusitis indication 75498004
Infective otitis externa indication 86981007 DOID:9463
Infection of bone indication 111253001
Infectious disease of abdomen indication 128070006
Bacterial conjunctivitis indication 128350005 DOID:9700
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Acute Moraxella catarrhalis bronchitis indication 195722003
Proteus pneumonia indication 195888009
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Acute bacterial bronchitis indication 233598009
Infective cystitis indication 236620008
Chancroid indication 266143009 DOID:13778
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Infectious disorder of joint indication 363162000
Infection due to Staphylococcus aureus indication 406602003
Anthrax indication 409498004 DOID:7427
Acute osteomyelitis indication 409780002
Nosocomial pneumonia indication 425464007
Urinary tract infection caused by Klebsiella indication 369001000119100
Skin and Skin Structure Pseudomonas Aeruginosa Infection indication
Complicated UTI with Pseudomonas Aeruginosa indication
Staphylococcus Epidermidis Urinary Tract Infection indication
Pseudomonas Aeruginosa Joint Infection indication
Complicated Proteus UTI indication
Skin and Skin Structure Providencia Infection indication
Complicated Bacterial Peritonitis indication
Staphylococcus Saprophyticus Urinary Tract Infection indication
Haemophilus Parainfluenzae Pneumonia indication
Enterobacter Pneumonia indication
Skin and Skin Structure Citrobacter Infection indication
Moraxella Catarrhalis Chronic Bronchitis indication
Diarrhea due to E. Coli indication
Klebsiella Nosocomial Pneumonia indication
Citrobacter Urinary Tract Infection indication
Enterococcus Urinary Tract Infection indication
Serratia Joint Infection indication
Skin and Skin Structure Proteus Infection indication
EnterobacterJoint Infection indication
Enterobacter Osteomyelitis indication
Nosocomial Pneumonia due to Haemophilus Influenzae indication
Complicated Bacteroides Peritonitis indication
Complicated E. Coli Peritonitis indication
Morganella Morganii Urinary Tract Infection indication
Bacterial Corneal Ulcer Infection indication
E. Coli Cystitis indication
Staphylococcus Aureus Otitis Externa indication
Staphylococcus Cystitis indication
Chronic Bacterial Prostatitis indication
Pseudomonas Aeruginosa Urinary Tract Infection indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Serratia Osteomyelitis indication
Staphylococcus Epidermidis Skin and Skin Structure Infection indication
Enterococcus Complicated UTI indication
Providencia Urinary Tract Infection indication
Complicated Klebsiella Peritonitis indication
Skin and Skin Structure Serratia Infection indication
Proteus Prostatitis indication
E. Coli Pyelonephritis indication
Skin and Skin Structure Morganella Morganii Infection indication
Serratia Urinary Tract Infection indication
Pseudomonas Aeruginosa Osteomyelitis indication
Inhalational anthrax off-label use 11389007
Traveler's diarrhea off-label use 11840006
Salmonella septicemia off-label use 49786009
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Diverticulitis of gastrointestinal tract off-label use 271366000
Ventilator-acquired pneumonia off-label use 429271009
Diabetic Foot Infection off-label use
Prevention of Meningococcal Meningitis off-label use
Achilles tendinitis contraindication 11654001
Lowered convulsive threshold contraindication 19260006
Torsades de pointes contraindication 31722008
Transplantation of heart contraindication 32413006
Tendinitis contraindication 34840004 DOID:971
Hypokalemia contraindication 43339004
Transplant of kidney contraindication 70536003
Epilepsy contraindication 84757009 DOID:1826
Transplant of lung contraindication 88039007
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Superimposed infection contraindication 193198003
Peripheral nerve disease contraindication 302226006
Viral ear infection contraindication 312137007
Pseudomembranous enterocolitis contraindication 397683000
Traumatic rupture of tendon contraindication 415749005
Congenital long QT syndrome contraindication 442917000
Shoulder Tendonitis contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.12 acidic
pKa2 8.54 Basic
pKa3 1.37 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
6% (60MG/ML) OTIPRIO OTONOMY INC N207986 Dec. 10, 2015 RX INJECTABLE, SUSPENSION OTIC March 2, 2021 TREATMENT OF ACUTE OTITIS EXTERNULL IN PATIENTS 6 MONTHS OF AGE AND OLDER DUE TO PSEUDOMONULLS AERUGINOSA AND STAPHYLOCOCCUS AUREUS

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA topoisomerase II Enzyme EC50 7.52 CHEMBL
DNA gyrase subunit A Enzyme INHIBITOR IC50 5.75 WOMBAT-PK CHEMBL
DNA topoisomerase 4 subunit A Enzyme INHIBITOR IC50 6 WOMBAT-PK
DNA topoisomerase 4 subunit A Enzyme IC50 5.66 WOMBAT-PK
DNA topoisomerase 4 subunit A Enzyme IC50 5.60 WOMBAT-PK
DNA gyrase subunit A Enzyme IC50 6.20 WOMBAT-PK
GABA-A receptor; anion channel Ion channel IC50 6.39 CHEMBL
Multidrug resistance protein mdtK Unclassified Kd 4.04 CHEMBL
Histamine H3 receptor GPCR Ki 9.18 CHEMBL

External reference:

IDSource
4019307 VUID
N0000147503 NUI
D00186 KEGG_DRUG
86393-32-0 SECONDARY_CAS_RN
4019306 VANDF
4019307 VANDF
C0008809 UMLSCUI
CHEBI:100241 CHEBI
CPF PDB_CHEM_ID
CHEMBL8 ChEMBL_ID
CHEMBL1202 ChEMBL_ID
CHEMBL1077975 ChEMBL_ID
DB00537 DRUGBANK_ID
D002939 MESH_DESCRIPTOR_UI
2764 PUBCHEM_CID
10902 IUPHAR_LIGAND_ID
5446 INN_ID
5E8K9I0O4U UNII
235851 RXNORM
31644 MMSL
4451 MMSL
4452 MMSL
46904 MMSL
76342 MMSL
d00011 MMSL
002882 NDDF
003577 NDDF
004125 NDDF
20450009 SNOMEDCT_US
372840008 SNOMEDCT_US
428384006 SNOMEDCT_US
7577004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CILOXAN HUMAN PRESCRIPTION DRUG LABEL 1 0065-0654 OINTMENT 3 mg OPHTHALMIC NDA 19 sections
Ciloxan HUMAN PRESCRIPTION DRUG LABEL 1 0065-0656 SOLUTION/ DROPS 3 mg OPHTHALMIC NDA 21 sections
CIPROHC HUMAN PRESCRIPTION DRUG LABEL 2 0065-8531 SUSPENSION 2 mg AURICULAR (OTIC) NDA 16 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0065-8533 SUSPENSION/ DROPS 3 mg AURICULAR (OTIC) NDA 27 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0078-0799 SUSPENSION/ DROPS 3 mg AURICULAR (OTIC) NDA 28 sections
CILOXAN HUMAN PRESCRIPTION DRUG LABEL 1 0078-0841 OINTMENT 3 mg OPHTHALMIC NDA 20 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9927 TABLET, FILM COATED 250 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9928 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9929 TABLET, FILM COATED 750 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0172-5311 TABLET, FILM COATED 250 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0172-5312 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0172-5313 TABLET, FILM COATED 750 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0378-7098 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0404-7187 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 24 sections
CIPROFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 0409-4777 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 34 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8147 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8367 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Ciprofloxacin and Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 2 0781-6186 SUSPENSION/ DROPS 3 mg AURICULAR (OTIC) NDA authorized generic 27 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6378 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-7083 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-036 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-079 TABLET 500 mg ORAL ANDA 27 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-147 TABLET, FILM COATED 250 mg ORAL ANDA 27 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-432 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-603 TABLET 250 mg ORAL ANDA 27 sections
CIPROFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 10544-604 TABLET, FILM COATED 250 mg ORAL ANDA 28 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-605 TABLET, FILM COATED 500 mg ORAL ANDA 17 sections
Ciprofloxacin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-606 TABLET 500 mg ORAL ANDA 25 sections
CIPROFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 10544-607 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-608 TABLET 500 mg ORAL ANDA 27 sections