DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
rifamycin 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antibiotics, rifamycin derivatives
4817
6998-60-3
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
aemcolo
rifacin
rifamycin
rifamycin sodium
CB-01-11
Rifamycin SV
Molecular weight: 697.78
Formula: C37H47NO12
CLOGP: 3.86
LIPINSKI: 3
HAC: 13
HDO: 6
TPSA: 201.31
ALOGS: -4.68
ROTB: 3
Status: ONP
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
0.60
g
P
ADMET properties:
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Property
Value
Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Bocci G, Oprea TI, Benet LZ
S (Water solubility)
1.30 mg/mL
Bocci G, Oprea TI, Benet LZ
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Approvals:
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Date
Agency
Company
Orphan
Nov. 16, 2018
FDA
COSMO TECHNOLOGIES
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
A07AA13
ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC
D06AX15
DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
ATC
J04AB03
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Antibiotics
ATC
S01AA16
SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
ATC
S02AA12
SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
CHEBI has role
CHEBI:33231
antitubercular agents
CHEBI has role
CHEBI:33281
antibiotics
FDA CS
M0019113
Rifamycins
FDA EPC
N0000175500
Rifamycin Antibacterial
MeSH PA
D018501
Antirheumatic Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Traveler's diarrhea
indication
11840006
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
2.94
acidic
pKa2
7.75
acidic
pKa3
8.72
acidic
pKa4
11.2
acidic
pKa5
12.55
acidic
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Orange Book patent data (new drug applications)
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Formulation strength
Trade name
Applicant
Application number
Approval date
Type
Dose form
Route
Patent number
Patent expiration date
Patent use
EQ 194MG BASE
AEMCOLO
REDHILL
N210910
Nov. 16, 2018
RX
TABLET, DELAYED RELEASE
ORAL
8741948
May 3, 2025
TREATMENT OF TRAVELERS DIARRHEA CAUSED BY NON-INVASIVE STRAINS OF ESCHERICHIA COLI IN ADULTS
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Orange Book exclusivity data (new drug applications)
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Formulation strength
Trade name
Applicant
Application number
Approval date
Type
Dose form
Route
Exclusivity date
Description
EQ 194MG BASE
AEMCOLO
REDHILL
N210910
Nov. 16, 2018
RX
TABLET, DELAYED RELEASE
ORAL
Nov. 16, 2023
NEW CHEMICAL ENTITY
EQ 194MG BASE
AEMCOLO
REDHILL
N210910
Nov. 16, 2018
RX
TABLET, DELAYED RELEASE
ORAL
Nov. 16, 2028
GENERATING ANTIBIOTIC INCENTIVES NOW
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Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Bile salt export pump
Transporter
O95342
ABCBB_HUMAN
IC50
5.20
CHEMBL
Solute carrier organic anion transporter family member 1B1
Transporter
Q9Y6L6
SO1B1_HUMAN
INHIBITOR
Ki
5.70
IUPHAR
Solute carrier organic anion transporter family member 1A2
Transporter
P46721
SO1A2_HUMAN
INHIBITOR
Ki
4.96
IUPHAR
DNA-directed RNA polymerase subunit beta
Enzyme
RPOB_ECOLI
INHIBITOR
UNKNOWN
DRUG LABEL
Bile salt export pump
Transporter
ABCBB_RAT
IC50
5.51
CHEMBL
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External reference:
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ID
Source
RFV
PDB_CHEM_ID
006067
NDDF
006068
NDDF
14897-39-3
SECONDARY_CAS_RN
2106357
RXNORM
2293
INN_ID
299330
MMSL
33895
MMSL
4038081
VANDF
406756000
SNOMEDCT_US
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
Aemcolo
HUMAN PRESCRIPTION DRUG LABEL
1
57841-1200
TABLET, DELAYED RELEASE
194 mg
ORAL
NDA
30 sections
Aemcolo
HUMAN PRESCRIPTION DRUG LABEL
1
57841-1200
TABLET, DELAYED RELEASE
194 mg
ORAL
NDA
30 sections
Aemcolo
HUMAN PRESCRIPTION DRUG LABEL
1
57841-1201
TABLET, DELAYED RELEASE
194 mg
ORAL
NDA
30 sections
Aemcolo
HUMAN PRESCRIPTION DRUG LABEL
1
57841-1201
TABLET, DELAYED RELEASE
194 mg
ORAL
NDA
30 sections
Aemcolo
HUMAN PRESCRIPTION DRUG LABEL
1
71068-001
TABLET, DELAYED RELEASE
194 mg
ORAL
NDA
30 sections
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Structure 🔎
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L1000
FAQ
rifamycin