rifamycin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, rifamycin derivatives 4817 6998-60-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aemcolo
  • rifacin
  • rifamycin
  • rifamycin sodium
  • CB-01-11
  • Rifamycin SV
  • Molecular weight: 697.78
  • Formula: C37H47NO12
  • CLOGP: 3.86
  • LIPINSKI: 3
  • HAC: 13
  • HDO: 6
  • TPSA: 201.31
  • ALOGS: -4.68
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.60 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 16, 2018 FDA COSMO TECHNOLOGIES

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AA13 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC D06AX15 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
ATC J04AB03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Antibiotics
ATC S01AA16 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
ATC S02AA12 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
CHEBI has role CHEBI:33231 antitubercular agent
MeSH PA D018501 Antirheumatic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Traveler's diarrhea indication 11840006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.94 acidic
pKa2 7.75 acidic
pKa3 8.72 acidic
pKa4 11.2 acidic
pKa5 12.55 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 194MG BASE AEMCOLO REDHILL N210910 Nov. 16, 2018 RX TABLET, DELAYED RELEASE ORAL 8741948 May 3, 2025 TREATMENT OF TRAVELERS' DIARRHEA CAUSED BY NON-INVASIVE STRAINS OF ESCHERICHIA COLI IN ADULTS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bile salt export pump Transporter IC50 5.20 CHEMBL
Solute carrier organic anion transporter family member 1A2 Unclassified INHIBITOR Ki 4.96 IUPHAR
Solute carrier organic anion transporter family member 1B1 Transporter INHIBITOR Ki 5.70 IUPHAR
DNA-directed RNA polymerase subunit beta Enzyme INHIBITOR UNKNOWN DRUG LABEL
Bile salt export pump Unclassified IC50 5.51 CHEMBL

External reference:

IDSource
D02549 KEGG_DRUG
C0073371 UMLSCUI
32086GS35Z UNII
14897-39-3 SECONDARY_CAS_RN
406756000 SNOMEDCT_US
d08756 MMSL
9385 RXNORM
6324616 PUBCHEM_CID
CHEBI:29673 CHEBI
CHEMBL437765 ChEMBL_ID
2293 INN_ID
RFV PDB_CHEM_ID
DB11753 DRUGBANK_ID
CHEMBL2105680 ChEMBL_ID
4570 IUPHAR_LIGAND_ID
C023808 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Aemcolo HUMAN PRESCRIPTION DRUG LABEL 1 71068-001 TABLET, DELAYED RELEASE 194 mg ORAL NDA 18 sections