rifamycin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, rifamycin derivatives 4817 6998-60-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aemcolo
  • rifacin
  • rifamycin
  • rifamycin sodium
  • CB-01-11
  • Rifamycin SV
  • Molecular weight: 697.78
  • Formula: C37H47NO12
  • CLOGP: 3.86
  • LIPINSKI: 3
  • HAC: 13
  • HDO: 6
  • TPSA: 201.31
  • ALOGS: -4.68
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.60 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 16, 2018 FDA COSMO TECHNOLOGIES

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AA13 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC D06AX15 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
ATC J04AB03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Antibiotics
ATC S01AA16 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
ATC S02AA12 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
FDA CS M0019113 Rifamycins
FDA EPC N0000175500 Rifamycin Antibacterial
MeSH PA D018501 Antirheumatic Agents
CHEBI has role CHEBI:33231 antitubercular
CHEBI has role CHEBI:33281 antibiotics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Traveler's diarrhea indication 11840006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.94 acidic
pKa2 7.75 acidic
pKa3 8.72 acidic
pKa4 11.2 acidic
pKa5 12.55 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bile salt export pump Transporter IC50 5.20 CHEMBL
Solute carrier organic anion transporter family member 1A2 Unclassified INHIBITOR Ki 4.96 IUPHAR
Solute carrier organic anion transporter family member 1B1 Transporter INHIBITOR Ki 5.70 IUPHAR
DNA-directed RNA polymerase subunit beta Enzyme INHIBITOR UNKNOWN DRUG LABEL
Bile salt export pump Unclassified IC50 5.51 CHEMBL

External reference:

IDSource
D02549 KEGG_DRUG
14897-39-3 SECONDARY_CAS_RN
4038081 VANDF
C4741581 UMLSCUI
CHEBI:26580 CHEBI
RFV PDB_CHEM_ID
CHEMBL2105680 ChEMBL_ID
6324616 PUBCHEM_CID
CHEMBL437765 ChEMBL_ID
DB11753 DRUGBANK_ID
C023808 MESH_SUPPLEMENTAL_RECORD_UI
4570 IUPHAR_LIGAND_ID
2293 INN_ID
DU69T8ZZPA UNII
2106357 RXNORM
299330 MMSL
33895 MMSL
d08756 MMSL
006067 NDDF
006068 NDDF
406756000 SNOMEDCT_US
713764001 SNOMEDCT_US
768973004 SNOMEDCT_US
768974005 SNOMEDCT_US
783681005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Aemcolo HUMAN PRESCRIPTION DRUG LABEL 1 71068-001 TABLET, DELAYED RELEASE 194 mg ORAL NDA 30 sections