doxycycline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, protein-synthesis inhibitors, tetracycline derivatives 961 564-25-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxycycline
  • doxycycline hyclate
  • doxycycline calcium
  • doxycycline hydrochloride
  • doxycycline hydrate
  • doxycycline HCl
  • acticlate
A synthetic tetracycline derivative with similar antimicrobial activity.
  • Molecular weight: 444.44
  • Formula: C22H24N2O8
  • CLOGP: -0.98
  • LIPINSKI: 1
  • HAC: 10
  • HDO: 6
  • TPSA: 181.62
  • ALOGS: -2.85
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O
0.10 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 41 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.43 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.69 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.46 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 14 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.289 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.679 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 2.046 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 2.198 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 38.300 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 24.360 % High 1
herg hERG pIC50 4.703 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.089 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.162 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 28.380 % High 1
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MAPKAPK5,MTOR,NTRK2,PDK1,PDK2,PIK3CA,PIK3CB,PIM1,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 63
kinase-selectivity-class ACVR2B,AURKC,AXL,BRAF,CDK16,CDK4,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,JAK2,MAP2K6,MAP3K14,MAP3K2,MAPK12,MAPK7,MAPK8,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 24
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.483 Moderate 0.67
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 5.458 High 1
mh-clint Mouse hepatocyte intrinsic clearance 9.795 High 1
mppb Mouse plasma protein binding (% unbound) 27 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 4.819 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 34.520 % High 1
rat-kpuu-brain Rat brain Kpuu 0.008 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 2.427 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 84.270 % High 1
rppb Rat plasma protein binding (% unbound) 17.950 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 897.429 uM High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 5, 1967 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Abortion incomplete 1793.79 10.12 522 180251 2618 90445056
Drug hypersensitivity 761.82 10.12 2339 178434 461270 89986404
Haemorrhage 590.37 10.12 710 180063 68659 90379015
Deep vein thrombosis postoperative 439.02 10.12 620 180153 70189 90377485
Autoimmune disorder 406.54 10.12 624 180149 76120 90371554
Road traffic accident 355.81 10.12 711 180062 106915 90340759
Sciatica 347.51 10.12 680 180093 100702 90346972
Lower limb fracture 298.38 10.12 576 180197 84437 90363237
Swollen joint count increased 293.01 10.12 670 180103 110536 90337138
Jarisch-Herxheimer reaction 269.11 10.12 77 180696 359 90447315
Fall 256.53 10.12 352 180421 481458 89966216
Pregnancy 251.09 10.12 447 180326 61600 90386074
Injury 235.30 10.12 896 179877 196453 90251221
Bone erosion 232.81 10.12 396 180377 52625 90395049
Rheumatoid factor positive 229.62 10.12 809 179964 170841 90276833
Toxicity to various agents 227.38 10.12 147 180626 287699 90159975
Lupus vulgaris 226.86 10.12 358 180415 44701 90402973
C-reactive protein 223.64 10.12 294 180479 31073 90416601
Rheumatic fever 218.15 10.12 737 180036 152384 90295290
C-reactive protein abnormal 205.59 10.12 640 180133 126789 90320885
Fibromyalgia 195.77 10.12 873 179900 205396 90242278
Retinitis 190.08 10.12 303 180470 38155 90409519
Hepatic cirrhosis 189.07 10.12 401 180372 62852 90384822
Exostosis 185.15 10.12 359 180414 52775 90394899
Death 182.31 10.12 400 180373 456151 89991523
Sleep disorder due to general medical condition, insomnia type 181.14 10.12 617 180156 128077 90319597
Adjustment disorder with depressed mood 169.86 10.12 360 180413 56393 90391281
Liver disorder 169.44 10.12 580 180193 120689 90326985
Lupus-like syndrome 167.73 10.12 328 180445 48518 90399156
Type 2 diabetes mellitus 164.21 10.12 821 179952 202423 90245251
Anti-cyclic citrullinated peptide antibody 160.77 10.12 233 180540 26988 90420686
Wheezing 157.25 10.12 910 179863 237170 90210504
Laryngitis 156.62 10.12 326 180447 50427 90397247
Lip dry 152.72 10.12 496 180277 100459 90347215
Prescribed underdose 152.07 10.12 409 180364 74610 90373064
Joint dislocation 146.60 10.12 294 180479 44288 90403386
Joint range of motion decreased 146.33 10.12 597 180176 135046 90312628
Folliculitis 145.45 10.12 797 179976 203556 90244118
Cholangitis sclerosing 144.46 10.12 76 180697 2145 90445529
Febrile neutropenia 143.59 10.12 68 180705 158281 90289393
Completed suicide 143.18 10.12 55 180718 145003 90302671
Facet joint syndrome 142.21 10.12 476 180297 97913 90349761
Helicobacter infection 140.73 10.12 853 179920 225997 90221677
Hypotension 136.57 10.12 277 180496 325120 90122554
Foot deformity 134.01 10.12 338 180435 59313 90388361
Hypoaesthesia 132.31 10.12 1075 179698 313135 90134539
Duodenal ulcer perforation 128.43 10.12 818 179955 220470 90227204
Dislocation of vertebra 127.69 10.12 319 180454 55649 90392025
Asthma 127.15 10.12 873 179900 241287 90206387
Prescribed overdose 121.85 10.12 450 180323 97175 90350499
Ear infection 121.44 10.12 360 180413 69415 90378259
Oesophageal ulcer 120.48 10.12 92 180681 5027 90442647
Liver injury 119.85 10.12 663 180110 169904 90277770
Impaired healing 119.23 10.12 838 179935 233361 90214313
Urticaria 117.42 10.12 1043 179730 311691 90135983
Pulmonary fibrosis 115.81 10.12 473 180300 107030 90340644
Mobility decreased 114.40 10.12 874 179899 249860 90197814
X-ray abnormal 111.17 10.12 266 180507 45158 90402516
Constipation 109.06 10.12 249 180524 280146 90167528
Neutropenia 108.14 10.12 176 180597 224728 90222946
Blood pressure increased 107.89 10.12 141 180632 197076 90250598
Endometritis 107.41 10.12 51 180722 1149 90446525
Gait inability 106.73 10.12 575 180198 145881 90301793
Red blood cell sedimentation rate increased 106.68 10.12 385 180388 82210 90365464
Infection 106.28 10.12 1147 179626 360947 90086727
Blood cholesterol increased 103.94 10.12 741 180032 207271 90240403
Psoriatic arthropathy 102.51 10.12 793 179980 227542 90220132
Gastrointestinal mucosal necrosis 101.71 10.12 22 180751 18 90447656
Grip strength 98.77 10.12 105 180668 8860 90438814
Coma 98.21 10.12 14 180759 72618 90375056
Blister 97.51 10.12 854 179919 254144 90193530
Malignant neoplasm progression 95.19 10.12 47 180726 106823 90340851
Visual impairment 94.63 10.12 517 180256 131848 90315826
Irritable bowel syndrome 94.53 10.12 723 180050 206725 90240949
Wound infection 90.99 10.12 437 180336 105965 90341709
Depressed level of consciousness 89.65 10.12 18 180755 72766 90374908
Hidradenitis 89.09 10.12 72 180701 4275 90443399
Grip strength decreased 88.61 10.12 393 180380 92183 90355491
Platelet count decreased 85.61 10.12 88 180685 136881 90310793
Walking aid user 84.82 10.12 206 180567 35300 90412374
Anxiety 83.89 10.12 966 179807 308806 90138868
Cerebrovascular accident 82.28 10.12 75 180698 123458 90324216
Oedema 81.38 10.12 680 180093 199615 90248059
Sinusitis 81.22 10.12 1043 179730 342045 90105629
Osteoarthritis 80.86 10.12 667 180106 195063 90252611
Joint stiffness 80.60 10.12 339 180434 77703 90369971
Dry mouth 78.06 10.12 631 180142 183428 90264246
Inflammation 76.14 10.12 613 180160 177979 90269695
Porphyria acute 75.92 10.12 132 180641 17843 90429831
Somnolence 74.71 10.12 194 180579 208890 90238784
Overlap syndrome 73.49 10.12 88 180685 8460 90439214
Muscle injury 72.43 10.12 601 180172 176053 90271621
Amnesia 72.36 10.12 416 180357 108089 90339585
Cardiac failure 72.30 10.12 67 180706 109429 90338245
Hip arthroplasty 71.79 10.12 322 180451 75886 90371788
Hypercholesterolaemia 71.38 10.12 393 180380 100499 90347175
Urinary tract infection 71.30 10.12 340 180433 305292 90142382
Heavy menstrual bleeding 70.63 10.12 138 180635 20392 90427282
Hyperkalaemia 70.40 10.12 21 180752 64943 90382731
Pelvic inflammatory disease 69.19 10.12 44 180729 1786 90445888
Myelosuppression 68.68 10.12 12 180761 53579 90394095
Drug ineffective 68.62 10.12 2173 178600 1382125 89065549
Knee arthroplasty 68.50 10.12 338 180435 82844 90364830
Dehydration 68.27 10.12 182 180591 194265 90253409
Photosensitivity reaction 67.82 10.12 125 180648 17682 90429992
Haemoglobin decreased 65.25 10.12 141 180632 161815 90285859
Anti-neutrophil cytoplasmic antibody positive vasculitis 65.13 10.12 58 180715 3935 90443739
Breast cancer stage III 64.53 10.12 336 180437 84111 90363563
Osteoporosis 64.31 10.12 370 180403 96161 90351513
Musculoskeletal stiffness 64.15 10.12 887 179886 295645 90152029
Lung disorder 63.63 10.12 514 180259 149369 90298305
Macular degeneration 63.07 10.12 3 180770 37967 90409707
Seizure 63.06 10.12 131 180642 152498 90295176
Contusion 62.95 10.12 772 180001 250444 90197230
Delirium 60.61 10.12 386 180387 103973 90343701
White blood cell count decreased 60.50 10.12 154 180619 166955 90280719
Injection site reaction 60.02 10.12 57 180716 92023 90355651
Drug tolerance decreased 59.96 10.12 170 180603 31960 90415714
Overdose 59.71 10.12 142 180631 157567 90290107
Bradycardia 59.37 10.12 48 180725 83799 90363875
Swollen joint count 58.44 10.12 79 180694 8574 90439100
Amyloid arthropathy 57.63 10.12 38 180735 1642 90446032
Photoonycholysis 57.41 10.12 11 180762 0 90447674
Disease progression 56.95 10.12 144 180629 156471 90291203
Rheumatoid arthritis 56.95 10.12 1028 179745 361586 90086088
Idiopathic intracranial hypertension 56.40 10.12 51 180722 3530 90444144
Gastrointestinal injury 55.89 10.12 29 180744 795 90446879
Myocardial infarction 55.67 10.12 78 180695 105894 90341780
Hand deformity 55.63 10.12 865 179908 295497 90152177
Injection site pain 54.81 10.12 171 180602 173528 90274146
Drug interaction 54.75 10.12 325 180448 276128 90171546
Electrocardiogram QT prolonged 54.47 10.12 39 180734 72417 90375257
Sleep disorder 54.21 10.12 619 180154 197411 90250263
Blood creatinine increased 53.88 10.12 74 180699 101312 90346362
Back pain 52.70 10.12 393 180380 316782 90130892
Oxygen saturation decreased 52.68 10.12 83 180690 107400 90340274
Seronegative arthritis 52.63 10.12 114 180659 18120 90429554
Vomiting 51.60 10.12 1990 178783 786303 89661371
Blood pressure systolic increased 51.43 10.12 26 180747 58319 90389355
Pruritus 51.43 10.12 1429 179344 540096 89907578
Sedation 51.42 10.12 16 180757 48155 90399519
Drug ineffective for unapproved indication 49.43 10.12 263 180510 66381 90381293
Neutrophil count decreased 49.35 10.12 42 180731 71490 90376184
Acute kidney injury 49.03 10.12 406 180367 319981 90127693
Colitis ulcerative 48.99 10.12 244 180529 60022 90387652
Hypersensitivity 48.39 10.12 1218 179555 453459 89994215
Sleep disorder due to a general medical condition 48.28 10.12 197 180576 44541 90403133
Foetal exposure during pregnancy 48.22 10.12 13 180760 42962 90404712
Rhabdomyolysis 48.02 10.12 21 180752 51235 90396439
Pancreatitis acute 47.83 10.12 157 180616 31958 90415716
Chest pain 47.67 10.12 899 179874 318746 90128928
Ill-defined disorder 47.52 10.12 571 180202 184320 90263354
Bursitis 47.23 10.12 435 180338 131219 90316455
Cardiac arrest 46.86 10.12 86 180687 104849 90342825
Anaemia 46.21 10.12 465 180308 352337 90095337
Wound 46.17 10.12 855 179918 302125 90145549
Night sweats 45.96 10.12 425 180348 128341 90319333
Intestinal sepsis 45.55 10.12 19 180754 311 90447363
Product use in unapproved indication 45.54 10.12 932 179841 335304 90112370
Stomatitis 45.32 10.12 785 179988 273913 90173761
Hyperhidrosis 45.29 10.12 131 180642 136174 90311500
Cognitive disorder 45.19 10.12 43 180730 69364 90378310
Atrial fibrillation 44.69 10.12 128 180645 133483 90314191
Pleural effusion 44.68 10.12 98 180675 111893 90335781
Glossodynia 44.59 10.12 895 179878 320884 90126790
Breast cancer 44.41 10.12 26 180747 53735 90393939
Obesity 44.32 10.12 361 180412 105146 90342528
Renal impairment 43.94 10.12 90 180683 105331 90342343
Heart rate increased 43.26 10.12 101 180672 112801 90334873
Intracranial pressure increased 42.71 10.12 60 180713 6751 90440923
Cough 42.44 10.12 501 180272 368461 90079213
Hepatic enzyme increased 41.87 10.12 978 179795 359758 90087916
Hyponatraemia 41.74 10.12 132 180641 133406 90314268
Cerebral haemorrhage 41.56 10.12 9 180764 34513 90413161
Therapy non-responder 41.39 10.12 436 180337 136268 90311406
Cardio-respiratory arrest 41.25 10.12 39 180734 63101 90384573
Injection site erythema 41.14 10.12 84 180689 98418 90349256
Drug abuse 40.91 10.12 63 180710 82284 90365390
Metabolic acidosis 40.52 10.12 31 180742 55645 90392029
Glomerulonephritis minimal lesion 40.14 10.12 18 180755 354 90447320
Herpes zoster 40.13 10.12 80 180693 94564 90353110
Maternal exposure timing unspecified 40.06 10.12 117 180656 22366 90425308
Rash 39.65 10.12 1954 178819 794146 89653528
Live birth 39.57 10.12 282 180491 78825 90368849
Hepatotoxicity 39.56 10.12 21 180752 45821 90401853
Multiple sclerosis relapse 39.52 10.12 28 180745 52277 90395397
Uterine perforation 39.37 10.12 61 180712 7493 90440181
Hypokalaemia 39.32 10.12 132 180641 130984 90316690
Heart rate decreased 38.67 10.12 30 180743 53475 90394199
Septic shock 38.45 10.12 68 180705 84092 90363582
Colitis 38.23 10.12 50 180723 69892 90377782
Influenza 37.92 10.12 146 180627 139118 90308556
Arthritis 37.58 10.12 504 180269 166811 90280863
Blood glucose increased 37.46 10.12 84 180689 95162 90352512
Peripheral venous disease 37.35 10.12 291 180482 83630 90364044
Oesophagitis 36.92 10.12 96 180677 17153 90430521
Hemiparesis 36.90 10.12 9 180764 31810 90415864
General physical health deterioration 36.78 10.12 948 179825 354167 90093507
Gastrointestinal haemorrhage 35.98 10.12 79 180694 90169 90357505
Premature baby 35.92 10.12 4 180769 25073 90422601
Treatment failure 35.87 10.12 826 179947 303102 90144572
Decreased appetite 35.51 10.12 993 179780 375547 90072127
Gastrointestinal disorder 35.23 10.12 713 180060 255974 90191700
Blood pressure fluctuation 34.68 10.12 32 180741 52381 90395293
Disability 34.56 10.12 167 180606 40578 90407096
Synovitis 34.35 10.12 881 179892 328871 90118803
Intentional overdose 34.32 10.12 86 180687 93748 90353926
Cytokine release syndrome 34.27 10.12 7 180766 27966 90419708
Cardiac failure congestive 34.15 10.12 93 180680 98601 90349073
Lip swelling 34.02 10.12 160 180613 38450 90409224
Condition aggravated 33.52 10.12 1480 179293 594065 89853609
Blood creatine phosphokinase increased 33.39 10.12 13 180760 34010 90413664
Injection site bruising 33.36 10.12 33 180740 52274 90395400
Blood pressure decreased 32.89 10.12 62 180711 74833 90372841
Thrombocytopenia 32.60 10.12 263 180510 208462 90239212
Renal failure 32.14 10.12 143 180630 130864 90316810
Pancreatitis 32.12 10.12 244 180529 69582 90378092
Blood bilirubin increased 31.89 10.12 24 180749 43446 90404228
Premature delivery 31.66 10.12 19 180754 38743 90408931
Wrong technique in product usage process 31.65 10.12 59 180714 71512 90376162
Fluid retention 31.24 10.12 82 180691 88009 90359665
Neoplasm progression 30.83 10.12 26 180747 44460 90403214
Pneumonia aspiration 30.82 10.12 22 180751 40918 90406756
Device expulsion 30.74 10.12 22 180751 40864 90406810
Hypocalcaemia 30.31 10.12 24 180749 42344 90405330
Diabetic ketoacidosis 30.13 10.12 6 180767 24401 90423273
Spinal fusion surgery 30.12 10.12 72 180701 12211 90435463
Metastases to bone 30.00 10.12 7 180766 25498 90422176
Aspartate aminotransferase increased 29.94 10.12 105 180668 102832 90344842
Injection site pruritus 29.92 10.12 38 180735 53796 90393878
Coronary artery disease 29.61 10.12 15 180758 33608 90414066
Cystitis 29.50 10.12 55 180718 66663 90381011
Discomfort 29.16 10.12 735 180038 273600 90174074
Retained products of conception 29.09 10.12 11 180762 137 90447537
Feeling abnormal 28.82 10.12 205 180568 167030 90280644
Adverse drug reaction 28.49 10.12 357 180416 116344 90331330
Hypereosinophilic syndrome 28.30 10.12 14 180759 346 90447328
Q fever 28.13 10.12 11 180762 151 90447523
Respiratory failure 27.42 10.12 132 180641 118286 90329388
Cataract 27.20 10.12 65 180708 72027 90375647
Orthostatic hypotension 27.13 10.12 26 180747 41801 90405873
Influenza like illness 27.12 10.12 77 180696 80534 90367140
Onychomycosis 26.95 10.12 21 180752 37355 90410319
Cardiac disorder 26.85 10.12 45 180728 56827 90390847
Tremor 26.76 10.12 187 180586 152986 90294688
Urticaria contact 26.63 10.12 7 180766 22 90447652
Anaphylactic shock 26.53 10.12 15 180758 31602 90416072
Product quality issue 26.52 10.12 76 180697 79249 90368425
Hyperglycaemia 26.28 10.12 38 180735 50932 90396742
Balance disorder 26.28 10.12 102 180671 96978 90350696
Ascites 26.22 10.12 34 180739 47706 90399968
Pancytopenia 26.17 10.12 137 180636 120126 90327548
Fatigue 26.11 10.12 1966 178807 1152057 89295617
Adverse event 26.07 10.12 353 180420 117065 90330609
Acute myocardial infarction 25.93 10.12 19 180754 34871 90412803
Diabetes insipidus 25.88 10.12 32 180741 3180 90444494
Dysarthria 25.82 10.12 43 180730 54439 90393235
Incorrect route of product administration 25.62 10.12 181 180592 50445 90397229
Abdominal distension 25.06 10.12 155 180618 130446 90317228
Drug level increased 25.03 10.12 12 180761 27750 90419924
Lower respiratory tract infection 25.01 10.12 666 180107 249993 90197681
Anti-cyclic citrullinated peptide antibody positive 24.99 10.12 633 180140 235800 90211874
Sepsis 24.78 10.12 234 180539 179580 90268094
Dermatitis acneiform 24.70 10.12 45 180728 6309 90441365
Generalised tonic-clonic seizure 24.68 10.12 20 180753 34883 90412791
Apparent death 24.68 10.12 20 180753 1192 90446482
Angina pectoris 24.64 10.12 25 180748 39135 90408539
Pelvic pain 24.61 10.12 77 180696 15280 90432394
Pericarditis 24.49 10.12 709 180064 269442 90178232
Lyme disease 24.46 10.12 36 180737 4226 90443448
Sinobronchitis 24.40 10.12 16 180757 685 90446989
Injection site haemorrhage 24.39 10.12 13 180760 28305 90419369
Finger deformity 24.34 10.12 18 180755 32879 90414795
Rash pruritic 24.31 10.12 261 180512 81953 90365721
Interstitial lung disease 24.24 10.12 75 180698 76330 90371344
Blood test abnormal 24.15 10.12 6 180767 20946 90426728
Femur fracture 24.11 10.12 34 180739 46048 90401626
Loss of consciousness 24.11 10.12 172 180601 140066 90307608
Leukopenia 24.06 10.12 111 180662 100599 90347075
Radiculopathy 24.03 10.12 4 180769 18501 90429173
Muscle spasms 23.93 10.12 665 180108 251218 90196456
Palpitations 23.85 10.12 167 180606 136561 90311113
Inappropriate schedule of product administration 23.83 10.12 188 180585 149745 90297929
Acne pustular 23.79 10.12 11 180762 233 90447441
Conjunctival cyst 23.78 10.12 8 180765 69 90447605
Foetal death 23.76 10.12 6 180767 20717 90426957
Altered state of consciousness 23.66 10.12 17 180756 31515 90416159
Drug-induced liver injury 23.66 10.12 280 180493 90038 90357636
Disorientation 23.63 10.12 32 180741 44082 90403592
Dementia 23.61 10.12 9 180764 23852 90423822
Pain 23.53 10.12 1691 179082 994650 89453024
Chronic sinusitis 23.51 10.12 9 180764 23793 90423881
Hypothyroidism 23.31 10.12 44 180729 53083 90394591
Cytomegalovirus infection 23.23 10.12 12 180761 26590 90421084
Neurotoxicity 23.15 10.12 7 180766 21460 90426214
Gamma-glutamyltransferase increased 23.01 10.12 25 180748 37927 90409747
Accidental overdose 22.89 10.12 14 180759 28259 90419415
Urinary retention 22.73 10.12 25 180748 37719 90409955
Gastrooesophageal reflux disease 22.69 10.12 217 180556 166120 90281554
Spondylitis 22.64 10.12 71 180702 14107 90433567
Ischaemic stroke 22.54 10.12 8 180765 22158 90425516
Mucosal inflammation 22.51 10.12 51 180722 57574 90390100
Arrhythmia 22.38 10.12 31 180742 42301 90405373
Metastases to liver 22.32 10.12 15 180758 28792 90418882
Adverse reaction 22.32 10.12 16 180757 29696 90417978
Papilloedema 22.30 10.12 36 180737 4579 90443095
Asthenia 22.27 10.12 855 179918 532896 89914778
Musculoskeletal pain 22.27 10.12 472 180301 170779 90276895
Bone marrow failure 22.12 10.12 19 180754 32202 90415472
Trichomegaly 22.05 10.12 8 180765 88 90447586
Body temperature decreased 21.93 10.12 10 180763 23806 90423868
Suicide attempt 21.86 10.12 77 180696 75322 90372352
Cerebral infarction 21.77 10.12 13 180760 26583 90421091
Acute myeloid leukaemia 21.77 10.12 7 180766 20633 90427041
Product prescribing error 21.66 10.12 17 180756 30128 90417546
Product dose omission issue 21.56 10.12 431 180342 291256 90156418
Hepatic function abnormal 21.50 10.12 37 180736 46251 90401423
Alanine aminotransferase increased 21.40 10.12 143 180630 118195 90329479
Motor dysfunction 21.23 10.12 6 180767 19224 90428450
Heart rate irregular 21.11 10.12 11 180762 24257 90423417
Stress 21.09 10.12 87 180686 81308 90366366
Ectopic pregnancy 20.99 10.12 29 180744 3212 90444462
Rosacea 20.96 10.12 40 180733 5807 90441867
Dysstasia 20.86 10.12 12 180761 25040 90422634
Fracture 20.75 10.12 9 180764 22067 90425607
Periarticular thenar erythema with onycholysis 20.54 10.12 7 180766 63 90447611
Cholestatic liver injury 20.26 10.12 31 180742 3766 90443908
Haematochezia 20.17 10.12 73 180700 70840 90376834
Abnormal behaviour 20.07 10.12 10 180763 22618 90425056
Palmar-plantar erythrodysaesthesia syndrome 19.89 10.12 16 180757 28007 90419667
Device capturing issue 19.86 10.12 6 180767 35 90447639
Red blood cell count decreased 19.80 10.12 39 180734 46312 90401362
Blood lactate dehydrogenase increased 19.43 10.12 14 180759 25918 90421756
Urosepsis 19.42 10.12 9 180764 21223 90426451
Alcohol use disorder 19.30 10.12 6 180767 39 90447635
Aggression 19.21 10.12 15 180758 26653 90421021
Device malfunction 19.02 10.12 9 180764 20968 90426706
Rhinorrhoea 18.99 10.12 101 180672 88215 90359459
Oropharyngeal pain 18.97 10.12 143 180630 115044 90332630
Myelodysplastic syndrome 18.90 10.12 9 180764 20894 90426780
Hypertension 18.90 10.12 1104 179669 456428 89991246
Rocky mountain spotted fever 18.80 10.12 6 180767 43 90447631
Transient ischaemic attack 18.73 10.12 36 180737 43140 90404534
Papule 18.65 10.12 46 180727 7956 90439718
Cardiogenic shock 18.61 10.12 13 180760 24455 90423219
Diabetes mellitus inadequate control 18.57 10.12 7 180766 18677 90428997
Arthralgia 18.40 10.12 1321 179452 777201 89670473
Proctitis 18.32 10.12 4 180769 15255 90432419
Weight fluctuation 18.26 10.12 83 180690 19666 90428008
Eosinophilic pneumonia chronic 18.21 10.12 9 180764 222 90447452
Extrapyramidal disorder 18.16 10.12 5 180768 16298 90431376
IIIrd nerve injury 18.11 10.12 4 180769 4 90447670
Coordination abnormal 18.11 10.12 10 180763 21346 90426328
Hepatitis chronic active 18.11 10.12 7 180766 93 90447581
Restlessness 18.06 10.12 27 180746 35693 90411981
Haematocrit decreased 18.04 10.12 35 180738 41797 90405877
Pulmonary hypertension 17.97 10.12 36 180737 42487 90405187
Lactic acidosis 17.87 10.12 47 180726 50416 90397258
Accidental exposure to product 17.79 10.12 36 180737 42330 90405344
Hip fracture 17.71 10.12 24 180749 33053 90414621
Hepatic steatosis 17.65 10.12 29 180744 36916 90410758
Lymphopenia 17.61 10.12 12 180761 22869 90424805
Nasal congestion 17.60 10.12 96 180677 83318 90364356
Oesophageal irritation 17.56 10.12 10 180763 331 90447343
Anuria 17.56 10.12 4 180769 14814 90432860
Pericardial effusion 17.52 10.12 29 180744 36804 90410870
Bone pain 17.50 10.12 64 180709 61919 90385755
Myalgia 17.44 10.12 245 180528 174880 90272794
Blood urea increased 17.39 10.12 21 180752 30392 90417282
Hiatus hernia 17.36 10.12 15 180758 25346 90422328
Lipoedema 17.34 10.12 10 180763 339 90447335
Musculoskeletal disorder 17.32 10.12 11 180762 21758 90425916
Colorectal cancer metastatic 17.27 10.12 14 180759 835 90446839
Multiple sclerosis 17.26 10.12 18 180755 27822 90419852
COVID-19 17.25 10.12 235 180538 168608 90279066
Rhinitis allergic 17.17 10.12 6 180767 16779 90430895
Incorrect dose administered 17.12 10.12 90 180683 78840 90368834
Immunodeficiency 17.10 10.12 38 180735 43196 90404478
Dyspnoea exertional 17.07 10.12 80 180693 72208 90375466
Intentional self-injury 17.05 10.12 20 180753 29314 90418360
Blood pressure diastolic decreased 17.02 10.12 17 180756 26809 90420865
Coeliac disease 17.01 10.12 40 180733 44570 90403104
Pulmonary oedema 16.95 10.12 65 180708 62015 90385659
B-lymphocyte abnormalities 16.88 10.12 9 180764 261 90447413
Injection site swelling 16.76 10.12 62 180711 59777 90387897
Skin neoplasm excision 16.72 10.12 19 180754 1727 90445947
Cyanosis 16.66 10.12 9 180764 19446 90428228
Dyspepsia 16.58 10.12 515 180258 197645 90250029
Medical observation 16.50 10.12 8 180765 189 90447485
Abdominal discomfort 16.46 10.12 1134 179639 476194 89971480
Lymphocyte count decreased 16.30 10.12 28 180745 35022 90412652
Cardiac murmur 16.20 10.12 8 180765 18186 90429488
Nematodiasis 16.15 10.12 5 180768 32 90447642
Respiratory disorder 16.12 10.12 199 180574 64617 90383057
Neuropathy peripheral 16.10 10.12 185 180588 136785 90310889
Blood calcium decreased 16.06 10.12 22 180751 30160 90417514
Sensory loss 16.01 10.12 8 180765 18067 90429607
Flushing 15.96 10.12 107 180666 88384 90359290
Skin odour abnormal 15.95 10.12 19 180754 1816 90445858
Lung neoplasm malignant 15.84 10.12 15 180758 24258 90423416
Neoplasm malignant 15.81 10.12 27 180746 33853 90413821
Withdrawal syndrome 15.81 10.12 13 180760 22511 90425163
Mitral valve incompetence 15.81 10.12 13 180760 22511 90425163
Sinus bradycardia 15.79 10.12 7 180766 16945 90430729
Hot flush 15.78 10.12 63 180710 59425 90388249
Haematotoxicity 15.64 10.12 3 180770 12532 90435142
Rales 15.61 10.12 6 180767 15821 90431853
Hypertensive crisis 15.56 10.12 8 180765 17776 90429898
Peptic ulcer 15.54 10.12 34 180739 5441 90442233
Thrombotic microangiopathy 15.47 10.12 6 180767 15737 90431937
Eating disorder 15.41 10.12 20 180753 28053 90419621
Hypokinesia 15.40 10.12 6 180767 15691 90431983
Bronchomalacia 15.36 10.12 8 180765 221 90447453
Acne conglobata 15.36 10.12 4 180769 12 90447662
Progressive multifocal leukoencephalopathy 15.33 10.12 6 180767 15649 90432025
Memory impairment 15.30 10.12 508 180265 196736 90250938
Gastric ulcer perforation 15.11 10.12 16 180757 1344 90446330
Epilepsy 15.03 10.12 99 180674 82107 90365567
SLE arthritis 14.96 10.12 12 180761 705 90446969
Sinus tachycardia 14.96 10.12 21 180752 28492 90419182
Hepatic failure 14.85 10.12 36 180737 39692 90407982
Internal injury 14.80 10.12 9 180764 337 90447337
C-reactive protein increased 14.80 10.12 470 180303 180919 90266755
Pulmonary pain 14.79 10.12 32 180741 5082 90442592
Blood glucose decreased 14.69 10.12 15 180758 23414 90424260
Pustule 14.63 10.12 23 180750 2860 90444814
Throat irritation 14.61 10.12 49 180724 48646 90399028
Glaucoma 14.54 10.12 12 180761 20743 90426931
Blood potassium increased 14.53 10.12 12 180761 20737 90426937
Pneumocystis jirovecii pneumonia 14.53 10.12 13 180760 21603 90426071
Disinhibition 14.49 10.12 14 180759 1054 90446620
Ureaplasma infection 14.47 10.12 13 180760 892 90446782
Transaminases increased 14.46 10.12 33 180740 37159 90410515
Hypoglycaemia 14.40 10.12 81 180692 69767 90377907
Erosive oesophagitis 14.36 10.12 18 180755 1813 90445861
Joint effusion 14.31 10.12 11 180762 19699 90427975
Metastases to lung 14.28 10.12 7 180766 15984 90431690
Sleep apnoea syndrome 14.18 10.12 26 180747 31721 90415953
Pyelonephritis 14.12 10.12 13 180760 21303 90426371
Disseminated mycobacterium avium complex infection 14.07 10.12 8 180765 264 90447410
Blood pressure systolic abnormal 13.97 10.12 11 180762 19467 90428207
Caesarean section 13.96 10.12 10 180763 18567 90429107
Unresponsive to stimuli 13.89 10.12 35 180738 38086 90409588
Tendon pain 13.88 10.12 26 180747 3722 90443952
Cardiomyopathy 13.77 10.12 12 180761 20194 90427480
Nephrogenic diabetes insipidus 13.70 10.12 13 180760 957 90446717
Tuberculosis 13.70 10.12 4 180769 12545 90435129
Mouth swelling 13.68 10.12 33 180740 5629 90442045
Agranulocytosis 13.65 10.12 31 180742 34971 90412703
Feeling cold 13.65 10.12 21 180752 27444 90420230
Flatulence 13.56 10.12 40 180733 41327 90406347
Secondary amyloidosis 13.55 10.12 7 180766 190 90447484
Arterial occlusive disease 13.52 10.12 4 180769 12442 90435232
Joint injury 13.51 10.12 28 180745 32636 90415038
Insomnia 13.44 10.12 803 179970 332671 90115003
Nervousness 13.42 10.12 30 180743 34026 90413648
Urine glucose/creatinine ratio increased 13.39 10.12 7 180766 195 90447479
Upper respiratory tract infection 13.38 10.12 343 180430 127975 90319699
Stress cardiomyopathy 13.28 10.12 5 180768 13350 90434324
Disseminated intravascular coagulation 13.27 10.12 14 180759 21524 90426150
Herpes simplex oesophagitis 13.26 10.12 7 180766 199 90447475
Tumour lysis syndrome 13.24 10.12 3 180770 11149 90436525
Affect lability 13.21 10.12 10 180763 18053 90429621
Multiple organ dysfunction syndrome 13.16 10.12 81 180692 68255 90379419
Product substitution issue 13.14 10.12 10 180763 17998 90429676
Granuloma skin 13.12 10.12 49 180724 10631 90437043
Status epilepticus 13.12 10.12 11 180762 18863 90428811
Dysphonia 13.09 10.12 73 180700 63011 90384663
Jaw fracture 13.09 10.12 21 180752 2657 90445017
Poisoning 13.09 10.12 7 180766 15210 90432464
Malaria 13.04 10.12 7 180766 206 90447468
Diabetes mellitus 12.96 10.12 76 180697 64799 90382875
Dyskinesia 12.96 10.12 34 180739 36500 90411174
Neuroleptic malignant syndrome 12.90 10.12 7 180766 15089 90432585
Colon cancer 12.88 10.12 3 180770 10941 90436733
Nail hypertrophy 12.74 10.12 4 180769 27 90447647
Vaginal discharge 12.74 10.12 12 180761 19452 90428222
Uveitis 12.70 10.12 8 180765 15895 90431779
Keratitis 12.67 10.12 26 180747 3980 90443694
Procedural pain 12.65 10.12 30 180743 33330 90414344
Schizophrenia 12.62 10.12 7 180766 14907 90432767
VIth nerve paralysis 12.62 10.12 12 180761 886 90446788
Back injury 12.61 10.12 49 180724 46573 90401101
Tricuspid valve incompetence 12.58 10.12 9 180764 16722 90430952
Fistula discharge 12.57 10.12 13 180760 1062 90446612
Atrial flutter 12.56 10.12 3 180770 10755 90436919
Impaired work ability 12.55 10.12 12 180761 19314 90428360
Pulmonary mass 12.47 10.12 24 180749 28748 90418926
Post treatment Lyme disease syndrome 12.37 10.12 3 180770 6 90447668
Medical device site hyperaesthesia 12.37 10.12 3 180770 6 90447668
Allergic sinusitis 12.35 10.12 18 180755 2095 90445579
Dysphagia 12.30 10.12 154 180619 112124 90335550
Noninfective oophoritis 12.26 10.12 5 180768 77 90447597
Nervous system disorder 12.25 10.12 15 180758 21578 90426096
Gastroenteritis 12.14 10.12 25 180748 29204 90418470
Renal disorder 12.12 10.12 37 180736 37822 90409852
Hypertransaminasaemia 12.11 10.12 63 180710 15762 90431912
Therapy interrupted 12.10 10.12 55 180718 50053 90397621
Urine output decreased 12.07 10.12 5 180768 12598 90435076
Naevoid melanoma 12.06 10.12 3 180770 7 90447667
Osteonecrosis of jaw 11.97 10.12 39 180734 39064 90408610
Ataxia 11.95 10.12 11 180762 18031 90429643
Product complaint 11.92 10.12 6 180767 13494 90434180
Head injury 11.86 10.12 28 180745 31160 90416514
Lymphadenopathy 11.81 10.12 49 180724 45726 90401948
Onychalgia 11.81 10.12 13 180760 1141 90446533
Disturbance in attention 11.81 10.12 51 180722 47058 90400616
Optic perineuritis 11.78 10.12 3 180770 8 90447666
Cardiotoxicity 11.77 10.12 4 180769 11385 90436289
Spinal fracture 11.76 10.12 16 180757 22000 90425674
Hemiplegia 11.75 10.12 9 180764 16151 90431523
Foot fracture 11.70 10.12 22 180751 26584 90421090
Inappropriate antidiuretic hormone secretion 11.66 10.12 13 180760 19492 90428182
Drug dose omission by device 11.66 10.12 3 180770 10228 90437446
Shock 11.63 10.12 25 180748 28753 90418921
Nodular vasculitis 11.61 10.12 5 180768 89 90447585
Hypophagia 11.60 10.12 35 180738 35902 90411772
Drug withdrawal syndrome 11.56 10.12 25 180748 28698 90418976
Small intestine ulcer 11.35 10.12 8 180765 386 90447288
Pulmonary embolism 11.32 10.12 188 180585 130632 90317042
Cholelithiasis 11.31 10.12 60 180713 52446 90395228
Ventricular fibrillation 11.31 10.12 7 180766 14037 90433637
Platelet count increased 11.31 10.12 15 180758 20844 90426830
Food allergy 11.26 10.12 21 180752 25457 90422217
Device leakage 11.25 10.12 3 180770 9988 90437686
Pulmonary arterial hypertension 11.21 10.12 22 180751 26165 90421509
Pseudoporphyria 11.21 10.12 7 180766 275 90447399
Pre-eclampsia 11.21 10.12 4 180769 11044 90436630
False negative investigation result 11.04 10.12 6 180767 181 90447493
Blood parathyroid hormone decreased 11.04 10.12 51 180722 12165 90435509
Speech disorder 11.03 10.12 50 180723 45535 90402139
Electrolyte imbalance 11.01 10.12 19 180754 23726 90423948
Terminal state 11.01 10.12 20 180753 2798 90444876
Swollen tongue 10.96 10.12 140 180633 45816 90401858
Eructation 10.94 10.12 4 180769 10878 90436796
Nail disorder 10.87 10.12 71 180702 58996 90388678
Benign familial pemphigus 10.85 10.12 3 180770 12 90447662
Obstructive airways disorder 10.85 10.12 22 180751 25847 90421827
Pain in jaw 10.81 10.12 54 180719 47931 90399743
Lactobacillus infection 10.81 10.12 5 180768 106 90447568
Neck pain 10.79 10.12 161 180612 113802 90333872
Transplant rejection 10.78 10.12 6 180767 12752 90434922
Dermatitis atopic 10.78 10.12 82 180691 23390 90424284
Abdominal pain upper 10.70 10.12 786 179987 331888 90115786
Cutaneous tuberculosis 10.66 10.12 6 180767 194 90447480
Foreign body reaction 10.64 10.12 5 180768 110 90447564
Systemic lupus erythematosus 10.64 10.12 849 179924 361047 90086627
Lymphoma 10.63 10.12 7 180766 13584 90434090
Laboratory test abnormal 10.63 10.12 129 180644 41725 90405949
Sarcoidosis 10.60 10.12 4 180769 10669 90437005
Fixed eruption 10.49 10.12 15 180758 1715 90445959
Ulcerative keratitis 10.44 10.12 22 180751 3431 90444243
Osteonecrosis 10.43 10.12 23 180750 26218 90421456
Asymptomatic bacteriuria 10.36 10.12 7 180766 315 90447359
Haemorrhage intracranial 10.34 10.12 9 180764 15153 90432521
Premature labour 10.32 10.12 7 180766 13369 90434305
Breast cancer metastatic 10.29 10.12 9 180764 15123 90432551
Ear pain 10.27 10.12 167 180606 57535 90390139
Enthesopathy 10.26 10.12 3 180770 9401 90438273
Agitation 10.26 10.12 85 180688 67013 90380661
Faecaloma 10.21 10.12 4 180769 10427 90437247
Hypotonia 10.21 10.12 5 180768 11421 90436253
Corneal perforation 10.19 10.12 9 180764 604 90447070
Spinal osteoarthritis 10.15 10.12 14 180759 19134 90428540
Mydriasis 10.13 10.12 9 180764 15003 90432671

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Jarisch-Herxheimer reaction 865.78 11.02 199 50259 604 42570273
Photosensitivity reaction 203.35 11.02 147 50311 12555 42558322
Drug ineffective for unapproved indication 151.19 11.02 227 50231 45936 42524941
Drug ineffective 147.44 11.02 1257 49201 628940 41941937
Fixed eruption 139.96 11.02 65 50393 2389 42568488
Rash 137.14 11.02 669 49789 276285 42294592
Gastrointestinal mucosal necrosis 130.67 11.02 33 50425 164 42570713
Breath sounds abnormal 126.67 11.02 109 50349 11984 42558893
Gastrointestinal injury 118.13 11.02 46 50412 1083 42569794
Congenital hiatus hernia 111.67 11.02 77 50381 6097 42564780
Hidradenitis 105.18 11.02 48 50410 1693 42569184
Drug hypersensitivity 102.57 11.02 304 50154 99085 42471792
Malignant melanoma in situ 95.06 11.02 52 50406 2715 42568162
Acne fulminans 90.84 11.02 27 50431 267 42570610
Treatment failure 87.18 11.02 214 50244 62410 42508467
Lip swelling 82.21 11.02 107 50351 18946 42551931
Oesophagitis 80.88 11.02 95 50363 15152 42555725
Drug abuse 77.47 11.02 15 50443 104756 42466121
Asthma 72.40 11.02 199 50259 62115 42508762
Soft tissue mass 67.82 11.02 30 50428 982 42569895
Febrile neutropenia 67.69 11.02 72 50386 185631 42385246
Neutrophilic dermatosis 66.88 11.02 22 50436 311 42570566
Bronchiectasis 66.79 11.02 94 50364 17925 42552952
Cholangitis sclerosing 66.05 11.02 36 50422 1866 42569011
Oesophageal ulcer 65.91 11.02 46 50412 3713 42567164
Multimorbidity 63.51 11.02 28 50430 909 42569968
Drug resistance 63.26 11.02 131 50327 34117 42536760
Micturition urgency 59.59 11.02 72 50386 11826 42559051
Drug reaction with eosinophilia and systemic symptoms 58.77 11.02 144 50314 41931 42528946
Wheezing 57.82 11.02 169 50289 54612 42516265
Oesophageal perforation 56.18 11.02 28 50430 1205 42569672
Hypercholesterolaemia 53.63 11.02 71 50387 12778 42558099
Productive cough 53.39 11.02 158 50300 51409 42519468
Benign prostatic hyperplasia 46.72 11.02 87 50371 20965 42549912
Crystal nephropathy 45.96 11.02 20 50438 629 42570248
Dermatitis acneiform 45.73 11.02 51 50407 7688 42563189
Skin exfoliation 45.59 11.02 130 50328 41423 42529454
Joint injury 43.56 11.02 69 50389 14607 42556270
Drug-induced liver injury 43.22 11.02 121 50337 38152 42532725
Pulmonary function test abnormal 42.70 11.02 31 50427 2663 42568214
Chronic obstructive pulmonary disease 42.12 11.02 167 50291 62947 42507930
Death 41.45 11.02 358 50100 470827 42100050
Obstructive airways disorder 41.44 11.02 91 50367 24668 42546209
Hyperoxaluria 41.39 11.02 13 50445 157 42570720
Stevens-Johnson syndrome 41.15 11.02 85 50373 22093 42548784
Gastric mucosal lesion 41.09 11.02 19 50439 691 42570186
Gastrooesophageal reflux disease 41.07 11.02 132 50326 44891 42525986
Dyspnoea 40.94 11.02 743 49715 441878 42128999
Acquired haemophilia 40.35 11.02 25 50433 1650 42569227
Superinfection 40.18 11.02 31 50427 2920 42567957
Autoimmune hepatitis 40.07 11.02 41 50417 5604 42565273
Myocardial infarction 39.90 11.02 53 50405 123956 42446921
Intracranial pressure increased 38.85 11.02 37 50421 4637 42566240
Skin plaque 38.77 11.02 41 50417 5822 42565055
Malaise 37.53 11.02 400 50058 211756 42359121
Corneal perforation 37.00 11.02 14 50444 304 42570573
Asthma-chronic obstructive pulmonary disease overlap syndrome 36.87 11.02 23 50435 1536 42569341
Full blood count abnormal 36.27 11.02 97 50361 29779 42541098
Lung consolidation 36.07 11.02 42 50416 6635 42564242
Inflammatory marker increased 35.67 11.02 42 50416 6714 42564163
Bacterial pericarditis 35.53 11.02 10 50448 80 42570797
Condition aggravated 35.27 11.02 467 49991 260287 42310590
Factitious disorder 35.11 11.02 9 50449 48 42570829
Acute generalised exanthematous pustulosis 35.11 11.02 47 50411 8548 42562329
Methaemoglobinaemia 34.03 11.02 38 50420 5736 42565141
General physical health deterioration 33.90 11.02 81 50377 151165 42419712
Pruritus 33.41 11.02 356 50102 188415 42382462
Hypotension 32.95 11.02 175 50283 257456 42313421
Bronchial hyperreactivity 32.41 11.02 23 50435 1906 42568971
Swelling face 31.98 11.02 88 50370 27466 42543411
Transplant failure 31.70 11.02 31 50427 4013 42566864
Melanocytic naevus 31.39 11.02 27 50431 2965 42567912
Urethritis mycoplasmal 30.50 11.02 7 50451 21 42570856
Platelet count decreased 29.66 11.02 76 50382 138505 42432372
Painful respiration 29.39 11.02 19 50439 1350 42569527
Eosinophilic myocarditis 29.34 11.02 19 50439 1354 42569523
Chest injury 28.95 11.02 21 50437 1801 42569076
Blood creatinine increased 28.75 11.02 54 50404 109949 42460928
Histoplasmosis disseminated 28.54 11.02 22 50436 2069 42568808
Coma 28.28 11.02 14 50444 53540 42517337
Autoimmune blistering disease 28.21 11.02 6 50452 11 42570866
Swollen tongue 27.88 11.02 71 50387 21160 42549717
Oral candidiasis 27.65 11.02 56 50402 14349 42556528
Dermatitis 27.51 11.02 50 50408 11825 42559052
Transient ischaemic attack 27.28 11.02 95 50363 33644 42537233
Papule 27.14 11.02 34 50424 5792 42565085
Nephrogenic diabetes insipidus 26.99 11.02 19 50439 1555 42569322
Pustule 26.89 11.02 17 50441 1162 42569715
Q fever 26.45 11.02 9 50449 142 42570735
Off label use 25.84 11.02 960 49498 637375 41933502
Dermatitis bullous 25.43 11.02 40 50418 8416 42562461
Rash pustular 25.41 11.02 34 50424 6181 42564696
Overdose 24.68 11.02 55 50403 105209 42465668
Eosinophilic pneumonia acute 24.38 11.02 14 50444 803 42570074
Ulcerative keratitis 24.29 11.02 20 50438 2068 42568809
Lyme disease 24.23 11.02 16 50442 1179 42569698
C-reactive protein increased 23.85 11.02 24 50434 63536 42507341
Acne 23.80 11.02 51 50407 13593 42557284
Blister 23.63 11.02 79 50379 27411 42543466
Vitamin K deficiency 23.29 11.02 11 50447 420 42570457
Primary coenzyme Q10 deficiency 22.96 11.02 4 50454 0 42570877
Iodine deficiency 22.96 11.02 4 50454 0 42570877
Vitamin B2 deficiency 22.96 11.02 4 50454 0 42570877
Fatty acid deficiency 22.96 11.02 4 50454 0 42570877
Ocular surface squamous neoplasia 22.81 11.02 6 50452 36 42570841
Lower respiratory tract infection 22.79 11.02 103 50355 41103 42529774
White blood cell count decreased 22.51 11.02 62 50396 110334 42460543
Cytokine release syndrome 21.53 11.02 13 50445 44514 42526363
Mycobacterial peritonitis 21.53 11.02 8 50450 165 42570712
Sleep disorder due to a general medical condition 21.52 11.02 57 50401 17396 42553481
Achromobacter infection 21.22 11.02 8 50450 172 42570705
Jaundice 21.06 11.02 89 50369 34500 42536377
Psoriasis 20.83 11.02 113 50345 48491 42522386
Selenium deficiency 20.73 11.02 4 50454 3 42570874
Skin lesion 20.67 11.02 75 50383 27099 42543778
Serotonin syndrome 20.64 11.02 3 50455 25842 42545035
Phrenic nerve paralysis 20.64 11.02 8 50450 186 42570691
Angina bullosa haemorrhagica 20.59 11.02 6 50452 55 42570822
Malignant neoplasm progression 20.55 11.02 63 50395 108337 42462540
Neutrophil count decreased 20.49 11.02 27 50431 63388 42507489
Radiation fibrosis - lung 20.48 11.02 5 50453 21 42570856
Haemoglobin decreased 20.44 11.02 84 50374 132387 42438490
Cough 20.43 11.02 310 50148 177793 42393084
Diaphragmatic paralysis 20.22 11.02 11 50447 568 42570309
Pancreatitis acute 20.16 11.02 86 50372 33478 42537399
Loss of personal independence in daily activities 20.14 11.02 114 50344 49702 42521175
Antinuclear antibody negative 20.11 11.02 5 50453 23 42570854
Tachyarrhythmia 20.02 11.02 24 50434 3908 42566969
Rosacea 20.01 11.02 15 50443 1353 42569524
Ischaemic cardiomyopathy 19.82 11.02 31 50427 6491 42564386
Infective pulmonary exacerbation of cystic fibrosis 19.50 11.02 34 50424 7784 42563093
Blood pressure increased 19.49 11.02 59 50399 101869 42469008
Skin depigmentation 19.49 11.02 10 50448 458 42570419
Dysbiosis 19.41 11.02 12 50446 789 42570088
Rash pruritic 19.34 11.02 85 50373 33518 42537359
Corynebacterium bacteraemia 19.32 11.02 7 50451 134 42570743
Therapeutic product effect incomplete 19.32 11.02 147 50311 70792 42500085
Masked fever 19.30 11.02 5 50453 28 42570849
Dyspnoea exertional 19.13 11.02 113 50345 50035 42520842
Weight increased 18.91 11.02 65 50393 107918 42462959
Hyperkalaemia 18.89 11.02 42 50416 80416 42490461
Skin hyperpigmentation 18.84 11.02 24 50434 4157 42566720
Toxicity to various agents 18.79 11.02 177 50281 228959 42341918
Myalgia 18.78 11.02 185 50273 95895 42474982
Distal intestinal obstruction syndrome 18.73 11.02 10 50448 497 42570380
Aortic aneurysm 18.51 11.02 33 50425 7690 42563187
Fall 18.45 11.02 183 50275 234337 42336540
Rash erythematous 18.33 11.02 81 50377 32010 42538867
Papilloedema 18.30 11.02 21 50437 3265 42567612
Skin reaction 17.97 11.02 31 50427 7036 42563841
Glutathione synthetase deficiency 17.96 11.02 4 50454 10 42570867
Immune reconstitution inflammatory syndrome 17.79 11.02 38 50420 10105 42560772
Blood glucose increased 17.69 11.02 38 50420 73661 42497216
Mycobacterium fortuitum infection 17.62 11.02 9 50449 408 42570469
Hair colour changes 17.49 11.02 17 50441 2185 42568692
SAPHO syndrome 17.38 11.02 9 50449 420 42570457
Gastroduodenal haemorrhage 17.36 11.02 7 50451 181 42570696
Laryngeal injury 17.22 11.02 3 50455 0 42570877
Gastritis erosive 17.16 11.02 29 50429 6474 42564403
Bronchitis 17.13 11.02 105 50353 47096 42523781
Dermatitis atopic 16.83 11.02 42 50416 12362 42558515
Periostosis 16.75 11.02 4 50454 15 42570862
Product use in unapproved indication 16.72 11.02 309 50149 184147 42386730
Tooth injury 16.72 11.02 13 50445 1238 42569639
Dysphagia 16.72 11.02 145 50313 72574 42498303
Walking aid user 16.68 11.02 18 50440 2615 42568262
Oesophageal stenosis 16.63 11.02 16 50442 2030 42568847
Genital rash 16.53 11.02 11 50447 821 42570056
Therapy non-responder 16.50 11.02 114 50344 53245 42517632
Alopecia scarring 16.35 11.02 4 50454 17 42570860
Keratitis fungal 16.27 11.02 7 50451 214 42570663
Necrotising panniculitis 16.10 11.02 5 50453 58 42570819
Immunosuppressant drug level increased 15.98 11.02 31 50427 7700 42563177
Babesiosis 15.94 11.02 7 50451 225 42570652
Corynebacterium infection 15.94 11.02 11 50447 872 42570005
Depressed level of consciousness 15.93 11.02 20 50438 47950 42522927
Penile erythema 15.88 11.02 7 50451 227 42570650
Flashback 15.79 11.02 6 50452 132 42570745
Staphylococcal infection 15.78 11.02 87 50371 37556 42533321
Rebound effect 15.75 11.02 30 50428 7349 42563528
Intentional overdose 15.53 11.02 23 50435 51433 42519444
Myelosuppression 15.50 11.02 15 50443 40446 42530431
Cerebral haemorrhage 15.45 11.02 14 50444 38952 42531925
Scar 15.29 11.02 28 50430 6660 42564217
Cardiomegaly 15.14 11.02 49 50409 16717 42554160
Odynophagia 15.04 11.02 28 50430 6742 42564135
Hepatitis A 15.02 11.02 9 50449 559 42570318
Altered state of consciousness 14.92 11.02 8 50450 29251 42541626
Ototoxicity 14.92 11.02 16 50442 2309 42568568
Rales 14.84 11.02 38 50420 11362 42559515
Rheumatoid arthritis 14.83 11.02 17 50441 42423 42528454
Cholestatic liver injury 14.72 11.02 20 50438 3689 42567188
Mouth ulceration 14.68 11.02 45 50413 14918 42555959
Tendon disorder 14.56 11.02 19 50439 3370 42567507
Breast inflammation 14.55 11.02 4 50454 29 42570848
Hypoacusis 14.55 11.02 52 50406 18650 42552227
Anaemia 14.48 11.02 239 50219 280039 42290838
Haemophagocytic lymphohistiocytosis 14.46 11.02 51 50407 18171 42552706
Prostate cancer 14.43 11.02 19 50439 44624 42526253
Oesophageal carcinoma 14.40 11.02 34 50424 9662 42561215
Rhinorrhoea 14.36 11.02 75 50383 31719 42539158
Periorbital swelling 14.27 11.02 13 50445 1540 42569337
Blood pressure fluctuation 14.26 11.02 7 50451 26901 42543976
Idiopathic intracranial hypertension 14.19 11.02 10 50448 820 42570057
Tubulointerstitial nephritis 13.96 11.02 74 50384 31474 42539403
Genital blister 13.93 11.02 3 50455 6 42570871
Retinopathy hypertensive 13.80 11.02 7 50451 313 42570564
Symmetrical drug-related intertriginous and flexural exanthema 13.78 11.02 10 50448 858 42570019
Pathogen resistance 13.71 11.02 37 50421 11413 42559464
Pemphigoid 13.68 11.02 37 50421 11430 42559447
Gastric ulcer 13.55 11.02 50 50408 18212 42552665
Acne conglobata 13.51 11.02 4 50454 39 42570838
Hypophosphataemia 13.50 11.02 4 50454 20941 42549936
Heart rate decreased 13.47 11.02 14 50444 36518 42534359
Infective exacerbation of bronchiectasis 13.44 11.02 8 50450 491 42570386
PaO2/FiO2 ratio decreased 13.42 11.02 4 50454 40 42570837
Blood pressure decreased 13.24 11.02 31 50427 58301 42512576
Agitation 13.19 11.02 36 50422 64278 42506599
Loose body in joint 13.16 11.02 4 50454 43 42570834
Mineral deficiency 13.16 11.02 4 50454 43 42570834
Mycobacterium chelonae infection 13.11 11.02 11 50447 1167 42569710
Papillary renal cell carcinoma 13.09 11.02 7 50451 349 42570528
Ischaemic stroke 13.02 11.02 5 50453 22228 42548649
Optic neuritis 13.02 11.02 20 50438 4122 42566755
Tumour lysis syndrome 13.02 11.02 5 50453 22226 42548651
Cyst 13.01 11.02 23 50435 5323 42565554
Post infection glomerulonephritis 12.87 11.02 5 50453 117 42570760
Clostridium difficile infection 12.80 11.02 57 50401 22602 42548275
Mastocytosis 12.68 11.02 4 50454 49 42570828
Abdominal distension 12.68 11.02 43 50415 71692 42499185
Oropharyngeal pain 12.66 11.02 90 50368 42420 42528457
Splenic infarction 12.64 11.02 15 50443 2416 42568461
Transfusion-related circulatory overload 12.53 11.02 9 50449 760 42570117
Haematochezia 12.52 11.02 32 50426 58404 42512473
Dry skin 12.51 11.02 99 50359 48239 42522638
Intentional product misuse 12.43 11.02 35 50423 61865 42509012
Oesophageal mass 12.41 11.02 3 50455 12 42570865
Cerebrovascular accident 12.39 11.02 66 50392 97094 42473783
Acute myocardial infarction 12.35 11.02 32 50426 58133 42512744
Rhabdomyolysis 12.32 11.02 49 50409 77970 42492907
Peripheral swelling 12.29 11.02 162 50296 90108 42480769
Protein total abnormal 12.25 11.02 7 50451 398 42570479
Cinchonism 12.21 11.02 3 50455 13 42570864
Erythema migrans 12.20 11.02 4 50454 56 42570821
Aggression 12.14 11.02 21 50437 44142 42526735
Sebaceous hyperplasia 12.13 11.02 5 50453 137 42570740
Lactic acidosis 12.01 11.02 22 50436 45239 42525638
Respiratory tract infection bacterial 12.01 11.02 13 50445 1896 42568981
Portal hypertensive gastropathy 11.98 11.02 9 50449 814 42570063
Prescription form tampering 11.94 11.02 8 50450 604 42570273
Mouth swelling 11.92 11.02 14 50444 2232 42568645
Arthritis allergic 11.86 11.02 3 50455 15 42570862
Psychogenic visual disorder 11.86 11.02 3 50455 15 42570862
Tinea manuum 11.86 11.02 3 50455 15 42570862
Drug effective for unapproved indication 11.81 11.02 25 50433 6608 42564269
Infusion related reaction 11.76 11.02 35 50423 60771 42510106
Herpes dermatitis 11.74 11.02 5 50453 149 42570728
Limb mass 11.71 11.02 9 50449 843 42570034
Amoebic dysentery 11.70 11.02 4 50454 64 42570813
Pyoderma gangrenosum 11.69 11.02 13 50445 1954 42568923
Ureaplasma infection 11.66 11.02 8 50450 628 42570249
Pain of skin 11.64 11.02 28 50430 8052 42562825
Loss of proprioception 11.53 11.02 7 50451 445 42570432
Bradycardia 11.50 11.02 57 50401 85427 42485450
Cutaneous sarcoidosis 11.44 11.02 5 50453 159 42570718
Illness 11.39 11.02 59 50399 24871 42546006
Corneal thinning 11.35 11.02 5 50453 162 42570715
Anterograde amnesia 11.32 11.02 6 50452 294 42570583
Penile rash 11.27 11.02 3 50455 19 42570858
Photoonycholysis 11.27 11.02 3 50455 19 42570858
Amino acid level decreased 11.15 11.02 5 50453 169 42570708
Calciphylaxis 11.13 11.02 10 50448 1163 42569714
Somnolence 11.12 11.02 110 50348 140995 42429882

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Abortion incomplete 1846.42 10.18 520 199513 2552 110386714
Jarisch-Herxheimer reaction 916.56 10.18 246 199787 971 110388295
Drug hypersensitivity 814.64 10.18 2221 197812 451869 109937397
Haemorrhage 440.27 10.18 734 199299 105958 110283308
Deep vein thrombosis postoperative 434.14 10.18 536 199497 58755 110330511
Autoimmune disorder 401.18 10.18 542 199491 64941 110324325
Swollen joint count increased 383.86 10.18 604 199429 83057 110306209
Sciatica 356.50 10.18 617 199416 91782 110297484
Pregnancy 339.50 10.18 440 199593 50627 110338639
Rheumatoid factor positive 327.67 10.18 731 199302 130909 110258357
Road traffic accident 322.60 10.18 644 199389 106754 110282512
Lower limb fracture 299.65 10.18 510 199523 74838 110314428
Rheumatic fever 286.53 10.18 664 199369 121915 110267351
Sleep disorder due to general medical condition, insomnia type 270.05 10.18 593 199440 105050 110284216
Febrile neutropenia 252.12 10.18 129 199904 316638 110072628
Injury 250.83 10.18 798 199235 176467 110212799
C-reactive protein 249.53 10.18 291 199742 30040 110359226
Fall 249.23 10.18 444 199589 603038 109786228
Toxicity to various agents 241.43 10.18 309 199724 480246 109909020
Fibromyalgia 240.55 10.18 768 199265 170141 110219125
Lupus vulgaris 222.17 10.18 290 199743 33593 110355673
Death 216.61 10.18 602 199431 698267 109690999
Photosensitivity reaction 216.36 10.18 249 199784 25340 110363926
C-reactive protein abnormal 215.58 10.18 618 199415 129077 110260189
Gastrointestinal mucosal necrosis 212.20 10.18 55 199978 183 110389083
Cholangitis sclerosing 208.02 10.18 110 199923 3472 110385794
Folliculitis 205.40 10.18 719 199314 166934 110222332
Duodenal ulcer perforation 198.11 10.18 739 199294 176961 110212305
Helicobacter infection 197.48 10.18 750 199283 181127 110208139
Type 2 diabetes mellitus 191.73 10.18 730 199303 176502 110212764
Hypotension 190.63 10.18 415 199618 523434 109865832
Bone erosion 188.49 10.18 317 199716 46054 110343212
Asthma 186.35 10.18 921 199112 249370 110139896
Lip dry 184.20 10.18 495 199538 99588 110289678
Wheezing 180.74 10.18 926 199107 254304 110134962
Facet joint syndrome 180.32 10.18 481 199552 96347 110292919
Rash 178.61 10.18 2267 197766 818697 109570569
Completed suicide 177.98 10.18 109 199924 242272 110146994
Liver disorder 163.93 10.18 598 199435 141645 110247621
X-ray abnormal 160.84 10.18 265 199768 37852 110351414
Gastrointestinal injury 159.56 10.18 75 199958 1828 110387438
Blister 158.91 10.18 822 199211 226554 110162712
Drug abuse 155.50 10.18 63 199970 177348 110211918
Liver injury 150.85 10.18 605 199428 149808 110239458
Retinitis 150.44 10.18 235 199798 32092 110357174
Glossodynia 149.92 10.18 795 199238 221209 110168057
Adjustment disorder with depressed mood 148.68 10.18 277 199756 43606 110345660
Exostosis 145.71 10.18 282 199751 45674 110343592
Lupus-like syndrome 145.15 10.18 263 199770 40529 110348737
Psoriatic arthropathy 144.25 10.18 721 199312 196040 110193226
Mobility decreased 140.21 10.18 820 199213 236602 110152664
Drug ineffective for unapproved indication 138.18 10.18 455 199578 102383 110286883
Platelet count decreased 136.73 10.18 129 199904 230314 110158952
Impaired healing 136.63 10.18 710 199323 196007 110193259
Coma 134.71 10.18 25 200008 117844 110271422
Hand deformity 133.15 10.18 761 199272 217745 110171521
Blood pressure increased 129.75 10.18 166 199867 258207 110131059
Joint range of motion decreased 129.40 10.18 499 199534 121333 110267933
Urticaria 128.10 10.18 1001 199032 317856 110071410
Laryngitis 128.10 10.18 255 199778 42156 110347110
Hypoaesthesia 127.65 10.18 989 199044 313234 110076032
Irritable bowel syndrome 124.81 10.18 608 199425 163607 110225659
Oesophageal ulcer 124.00 10.18 108 199925 7856 110381410
Neutropenia 121.65 10.18 315 199718 374305 110014961
Prescribed overdose 119.91 10.18 390 199643 87191 110302075
Endometritis 119.05 10.18 50 199983 924 110388342
Malignant neoplasm progression 115.45 10.18 88 199945 174479 110214787
Fixed eruption 115.40 10.18 80 199953 4152 110385114
Blood cholesterol increased 114.16 10.18 646 199387 184139 110205127
Depressed level of consciousness 113.89 10.18 31 200002 112247 110277019
Treatment failure 112.25 10.18 872 199161 276362 110112904
Ill-defined disorder 111.59 10.18 570 199463 156283 110232983
Anti-cyclic citrullinated peptide antibody 111.36 10.18 158 199875 19806 110369460
Pulmonary fibrosis 110.04 10.18 420 199613 101622 110287644
Grip strength 109.37 10.18 107 199926 9034 110380232
Infection 109 10.18 1067 198966 361133 110028133
Muscle injury 108.19 10.18 523 199510 140284 110248982
Sinusitis 107.57 10.18 910 199123 295778 110093488
Prescribed underdose 106.74 10.18 309 199724 64865 110324401
Wound 105.44 10.18 756 199277 233681 110155585
Myocardial infarction 105.42 10.18 115 199918 191968 110197298
Somnolence 105.31 10.18 239 199794 297210 110092056
Dislocation of vertebra 104.47 10.18 239 199794 43482 110345784
Foot deformity 103.89 10.18 254 199779 48226 110341040
Hepatic cirrhosis 101.62 10.18 311 199722 67315 110321951
Hyperkalaemia 99.74 10.18 61 199972 135735 110253531
Lip swelling 99.72 10.18 257 199776 50410 110338856
Gait inability 98.69 10.18 498 199535 135878 110253388
Haemoglobin decreased 98.02 10.18 188 199845 248539 110140727
Blood creatinine increased 96.55 10.18 113 199920 182776 110206490
Rheumatoid arthritis 95.75 10.18 894 199139 298719 110090547
Heavy menstrual bleeding 94.97 10.18 132 199901 16233 110373033
Pruritus 93.09 10.18 1523 198510 580037 109809229
Inflammation 91.47 10.18 631 199402 192607 110196659
Systemic lupus erythematosus 90.54 10.18 777 199256 253561 110135705
Drug tolerance decreased 89.76 10.18 171 199862 27369 110361897
Constipation 89.20 10.18 339 199694 357447 110031819
White blood cell count decreased 88.99 10.18 175 199858 229215 110160051
Musculoskeletal stiffness 87.43 10.18 831 199202 278991 110110275
Cerebrovascular accident 87.39 10.18 120 199913 181164 110208102
Overdose 86.75 10.18 183 199850 233611 110155655
Overlap syndrome 86.61 10.18 94 199939 8965 110380301
Dry mouth 86.57 10.18 639 199394 199309 110189957
Oesophagitis 85.93 10.18 172 199861 28543 110360723
Myelosuppression 85.13 10.18 32 200001 94308 110294958
Gastrointestinal disorder 84.46 10.18 736 199297 241216 110148050
Breath sounds abnormal 84.36 10.18 159 199874 25245 110364021
Joint dislocation 84.03 10.18 189 199844 34001 110355265
Porphyria acute 83.89 10.18 134 199899 18646 110370620
Congenital hiatus hernia 83.88 10.18 78 199955 6181 110383085
Neutrophil count decreased 83.83 10.18 58 199975 120883 110268383
Ear infection 83.76 10.18 277 199756 62455 110326811
Synovitis 82.68 10.18 808 199225 273284 110115982
Abdominal discomfort 81.68 10.18 1079 198954 392779 109996487
Seizure 80.50 10.18 175 199858 221010 110168256
Lower respiratory tract infection 80.48 10.18 731 199302 242375 110146891
Contusion 78.42 10.18 704 199329 232657 110156609
Hidradenitis 78.15 10.18 69 199964 5111 110384155
Hypersensitivity 78.13 10.18 1093 198940 402905 109986361
Discomfort 78.02 10.18 659 199374 214048 110175218
Hepatic enzyme increased 77.67 10.18 905 199128 319987 110069279
Osteoarthritis 77.56 10.18 581 199452 182042 110207224
Red blood cell sedimentation rate increased 76.11 10.18 312 199721 77990 110311276
Dehydration 75.52 10.18 256 199777 279255 110110011
Cardiac failure 75.51 10.18 140 199893 187486 110201780
Therapy non-responder 75.22 10.18 515 199518 156792 110232474
Bradycardia 74.90 10.18 103 199930 155414 110233852
Anaemia 72.28 10.18 637 199396 546449 109842817
Cardiac arrest 70.50 10.18 157 199876 196596 110192670
Acute kidney injury 70.48 10.18 772 199261 634658 109754608
Bursitis 70.45 10.18 439 199594 129479 110259787
Cytokine release syndrome 70.20 10.18 20 200013 70286 110318980
Hypercholesterolaemia 69.47 10.18 337 199696 90500 110298766
Sleep disorder 69.17 10.18 604 199429 198040 110191226
Pelvic inflammatory disease 68.41 10.18 40 199993 1540 110387726
Rhabdomyolysis 67.26 10.18 71 199962 120330 110268936
Urinary tract infection 66.77 10.18 333 199700 325949 110063317
Knee arthroplasty 66.48 10.18 263 199770 64685 110324581
Idiopathic intracranial hypertension 66.43 10.18 56 199977 3896 110385370
Intracranial pressure increased 65.71 10.18 88 199945 10447 110378819
Night sweats 65.46 10.18 441 199592 133542 110255724
Anti-cyclic citrullinated peptide antibody positive 64.75 10.18 556 199477 181428 110207838
Acne fulminans 64.64 10.18 23 200010 265 110389001
Swollen joint count 64.40 10.18 79 199954 8595 110380671
Blood pressure systolic increased 64.19 10.18 35 199998 82956 110306310
Oedema 63.79 10.18 620 199413 209356 110179910
Sleep disorder due to a general medical condition 63.33 10.18 223 199810 51889 110337377
Obesity 63.33 10.18 386 199647 112965 110276301
Hip arthroplasty 62.87 10.18 233 199800 55580 110333686
Photoonycholysis 62.47 10.18 14 200019 19 110389247
Stomatitis 62.22 10.18 755 199278 269487 110119779
Live birth 62.19 10.18 270 199763 69214 110320052
Visual impairment 61.27 10.18 435 199598 133993 110255273
Malignant melanoma in situ 61.21 10.18 51 199982 3491 110385775
Amyloid arthropathy 61.04 10.18 38 199995 1642 110387624
Anxiety 60.91 10.18 919 199114 344159 110045107
Cerebral haemorrhage 60.37 10.18 21 200012 64947 110324319
Metabolic acidosis 60.12 10.18 55 199978 99689 110289577
Cardio-respiratory arrest 59.60 10.18 73 199960 115763 110273503
Oxygen saturation decreased 58.11 10.18 123 199910 156859 110232407
Pancreatitis acute 57.66 10.18 239 199794 60035 110329231
Walking aid user 57.63 10.18 135 199898 24940 110364326
Sedation 57.47 10.18 27 200006 69656 110319610
Amnesia 57.03 10.18 356 199677 105052 110284214
Grip strength decreased 55.36 10.18 289 199744 79885 110309381
Blood glucose increased 54.97 10.18 97 199936 132399 110256867
Adverse drug reaction 54.93 10.18 353 199680 105206 110284060
Pericarditis 54.79 10.18 622 199411 218492 110170774
Gastrointestinal haemorrhage 54.57 10.18 138 199895 165380 110223886
Heart rate decreased 54.34 10.18 42 199991 82714 110306552
Breast cancer stage III 53.12 10.18 283 199750 78834 110310432
Hyponatraemia 53.07 10.18 208 199825 217445 110171821
Pneumonia aspiration 52.36 10.18 42 199991 81191 110308075
Wound infection 52.31 10.18 326 199707 96139 110293127
Disease progression 52.27 10.18 245 199788 243789 110145477
Blood pressure fluctuation 51.69 10.18 36 199997 74788 110314478
Maternal exposure timing unspecified 51.46 10.18 116 199917 20897 110368369
Anti-neutrophil cytoplasmic antibody positive vasculitis 51.42 10.18 56 199977 5361 110383905
Vomiting 51.04 10.18 2072 197961 908603 109480663
Blood pressure decreased 50.76 10.18 81 199952 115010 110274256
Peripheral venous disease 50.55 10.18 292 199741 83825 110305441
Lung disorder 50.51 10.18 523 199510 179524 110209742
Joint stiffness 49.65 10.18 247 199786 66996 110322270
Posterior reversible encephalopathy syndrome 49.21 10.18 3 200030 33858 110355408
Acute myocardial infarction 48.38 10.18 48 199985 83729 110305537
Pemphigus 48.30 10.18 597 199436 213973 110175293
Uterine perforation 47.11 10.18 60 199973 6780 110382486
Soft tissue mass 46.61 10.18 31 200002 1502 110387764
Intentional overdose 46.42 10.18 107 199926 132394 110256872
Drug interaction 45.83 10.18 633 199400 499550 109889716
Q fever 45.17 10.18 18 200015 289 110388977
Swelling 44.96 10.18 888 199145 350153 110039113
Gastric mucosal lesion 44.95 10.18 28 200005 1211 110388055
Colitis ulcerative 44.83 10.18 266 199767 77097 110312169
Anaphylactic shock 44.03 10.18 19 200014 51527 110337739
Mucosal inflammation 43.99 10.18 66 199967 96075 110293191
Hyperhidrosis 43.76 10.18 182 199851 187116 110202150
Sepsis 43.68 10.18 380 199653 326966 110062300
Altered state of consciousness 43.56 10.18 25 200008 57601 110331665
Maternal exposure during pregnancy 43.49 10.18 675 199358 254208 110135058
Hypokalaemia 43.43 10.18 176 199857 182272 110206994
Cognitive disorder 43.10 10.18 57 199976 87454 110301812
Injection site reaction 42.87 10.18 59 199974 89011 110300255
Adverse event 42.74 10.18 340 199693 108469 110280797
Malaise 42.43 10.18 1549 198484 670270 109718996
Drug intolerance 42.34 10.18 998 199035 405514 109983752
Neutrophilic dermatosis 42.28 10.18 23 200010 769 110388497
Rash pruritic 42.18 10.18 313 199720 97756 110291510
Injection site pain 42.12 10.18 172 199861 177750 110211516
Osteoporosis 42.05 10.18 286 199747 86866 110302400
Pancreatitis 41.64 10.18 301 199732 93232 110296034
Atrial fibrillation 41.64 10.18 244 199789 229398 110159868
Condition aggravated 41.37 10.18 1673 198360 733163 109656103
Hemiparesis 41.12 10.18 14 200019 43889 110345377
Neoplasm progression 40.89 10.18 34 199999 64561 110324705
Colitis 40.58 10.18 77 199956 102246 110287020
Arthropathy 40.48 10.18 738 199295 286784 110102482
Joint swelling 40.42 10.18 1068 198965 441777 109947489
Lactic acidosis 40.29 10.18 66 199967 92745 110296521
Hepatic function abnormal 40.18 10.18 62 199971 89233 110300033
Thrombocytopenia 40.17 10.18 420 199613 348465 110040801
Diabetic ketoacidosis 40.12 10.18 13 200020 42045 110347221
Haematochezia 39.90 10.18 94 199939 115430 110273836
Chest pain 39.80 10.18 926 199107 375449 110013817
Oesophageal perforation 39.79 10.18 29 200004 1630 110387636
Dermatitis acneiform 39.14 10.18 77 199956 12618 110376648
Aggression 38.94 10.18 30 200003 59180 110330086
Ischaemic stroke 38.93 10.18 13 200020 41250 110348016
Herpes zoster 38.39 10.18 87 199946 108292 110280974
Dysarthria 38.24 10.18 58 199975 84063 110305203
Drug reaction with eosinophilia and systemic symptoms 38.18 10.18 267 199766 81828 110307438
Abdominal distension 37.96 10.18 175 199858 174928 110214338
Cytomegalovirus infection 37.87 10.18 26 200007 54418 110334848
Acute myeloid leukaemia 37.75 10.18 11 200022 38099 110351167
Inappropriate schedule of product administration 37.65 10.18 215 199818 203422 110185844
Renal impairment 37.57 10.18 194 199839 188251 110201015
Multimorbidity 37.43 10.18 27 200006 1493 110387773
Neuroleptic malignant syndrome 37.28 10.18 8 200025 34051 110355215
Wrong technique in product usage process 37.09 10.18 63 199970 87285 110301981
Alopecia 36.91 10.18 892 199141 363861 110025405
Septic shock 36.84 10.18 153 199880 157375 110231891
Angina pectoris 36.77 10.18 35 199998 62260 110327006
Multiple sclerosis relapse 36.28 10.18 23 200010 50217 110339049
Respiratory depression 36.10 10.18 7 200026 31994 110357272
Papilloedema 36.06 10.18 55 199978 7354 110381912
Heart rate increased 35.99 10.18 136 199897 143698 110245568
Back pain 35.96 10.18 464 199569 370532 110018734
Nephrogenic diabetes insipidus 35.75 10.18 32 200001 2413 110386853
Hypothyroidism 35.37 10.18 48 199985 72851 110316415
Cardiogenic shock 35.29 10.18 31 200002 57307 110331959
Lyme disease 34.81 10.18 41 199992 4275 110384991
Hyperglycaemia 34.66 10.18 63 199970 85027 110304239
Pelvic pain 34.66 10.18 84 199949 15858 110373408
Tumour lysis syndrome 34.20 10.18 7 200026 30794 110358472
Hypophosphataemia 33.95 10.18 9 200024 33173 110356093
Pulmonary oedema 33.89 10.18 83 199950 100576 110288690
Musculoskeletal pain 33.65 10.18 491 199542 182532 110206734
Swelling face 33.31 10.18 283 199750 92038 110297228
Corneal perforation 33.16 10.18 21 200012 935 110388331
Blood bilirubin increased 33.00 10.18 54 199979 75918 110313348
Renal failure 32.95 10.18 257 199776 226317 110162949
Autoimmune hepatitis 32.18 10.18 78 199955 14726 110374540
Micturition urgency 32.01 10.18 92 199941 19228 110370038
Product use in unapproved indication 31.57 10.18 1045 198988 446332 109942934
Ulcerative keratitis 31.56 10.18 41 199992 4725 110384541
Interstitial lung disease 31.55 10.18 137 199896 139197 110250069
Poisoning 31.53 10.18 7 200026 29098 110360168
Sinobronchitis 31.43 10.18 16 200017 466 110388800
Suicide attempt 31.22 10.18 90 199943 103304 110285962
Extrapyramidal disorder 31.15 10.18 7 200026 28860 110360406
Gamma-glutamyltransferase increased 31.15 10.18 39 199994 61270 110327996
Swollen tongue 30.87 10.18 201 199832 60161 110329105
Cerebral infarction 30.74 10.18 29 200004 51809 110337457
Palmar-plantar erythrodysaesthesia syndrome 30.72 10.18 18 200015 41007 110348259
Retained products of conception 30.66 10.18 11 200022 130 110389136
Muscle spasms 30.52 10.18 688 199345 277469 110111797
Benign prostatic hyperplasia 30.38 10.18 87 199946 18147 110371119
Breast cancer 30.17 10.18 16 200017 38526 110350740
Aspartate aminotransferase increased 30.03 10.18 168 199865 159768 110229498
Urinary retention 29.83 10.18 50 199983 69633 110319633
Ventricular fibrillation 29.72 10.18 19 200014 41294 110347972
Generalised tonic-clonic seizure 29.69 10.18 33 200000 54647 110334619
Cholestatic liver injury 29.40 10.18 50 199983 7326 110381940
Loss of consciousness 29.33 10.18 221 199812 196085 110193181
Blood urea increased 28.94 10.18 34 199999 54923 110334343
Diabetes mellitus 28.92 10.18 88 199945 99293 110289973
Prostate cancer 28.92 10.18 16 200017 37625 110351641
Bacterial pericarditis 28.85 10.18 10 200023 106 110389160
Stress 28.76 10.18 96 199937 105252 110284014
Creatinine renal clearance decreased 28.73 10.18 3 200030 21812 110367454
Haematocrit decreased 28.71 10.18 47 199986 66070 110323196
Anuria 28.16 10.18 5 200028 24336 110364930
Cardiac failure congestive 28.14 10.18 159 199874 150841 110238425
Product prescribing error 27.85 10.18 31 200002 51300 110337966
Metastases to bone 27.70 10.18 11 200022 31361 110357905
Urethritis mycoplasmal 27.55 10.18 7 200026 21 110389245
Intestinal sepsis 27.43 10.18 19 200014 985 110388281
Urticaria contact 27.31 10.18 7 200026 22 110389244
Blood lactate dehydrogenase increased 27.25 10.18 24 200009 44310 110344956
Pleural effusion 27.06 10.18 199 199834 177510 110211756
Injection site erythema 26.98 10.18 84 199949 94092 110295174
Agitation 26.93 10.18 109 199924 112942 110276324
Blood test abnormal 26.93 10.18 9 200024 28545 110360721
Injection site haemorrhage 26.92 10.18 13 200020 33015 110356251
Renal disorder 26.72 10.18 30 200003 49449 110339817
Red blood cell count decreased 26.68 10.18 49 199984 65874 110323392
Premature delivery 26.63 10.18 11 200022 30621 110358645
Electrocardiogram QT prolonged 26.63 10.18 104 199929 108856 110280410
Drug resistance 26.60 10.18 184 199849 56190 110333076
Bladder cancer 26.19 10.18 3 200030 20289 110368977
Hyperoxaluria 26.14 10.18 13 200020 360 110388906
Macular degeneration 26.05 10.18 4 200029 21655 110367611
Abdominal pain upper 26.05 10.18 821 199212 348290 110040976
Ectopic pregnancy 25.84 10.18 26 200007 2271 110386995
Intentional product misuse 25.83 10.18 138 199895 132766 110256500
Stevens-Johnson syndrome 25.73 10.18 159 199874 46742 110342524
Disorientation 25.62 10.18 56 199977 70615 110318651
Hypocalcaemia 25.21 10.18 50 199983 65316 110323950
Alanine aminotransferase increased 25.09 10.18 212 199821 183561 110205705
Blood creatine phosphokinase increased 24.80 10.18 60 199973 73017 110316249
Lymphocyte count decreased 24.57 10.18 41 199992 57202 110332064
Conjunctival cyst 24.55 10.18 8 200025 69 110389197
Blood potassium increased 24.32 10.18 15 200018 33234 110356032
Accidental overdose 24.28 10.18 35 199998 51799 110337467
Cystitis 24.21 10.18 52 199981 65984 110323282
Serotonin syndrome 23.91 10.18 44 199989 59109 110330157
Respiratory arrest 23.89 10.18 43 199990 58256 110331010
Cyanosis 23.80 10.18 12 200021 29729 110359537
Glomerulonephritis minimal lesion 23.77 10.18 18 200015 1073 110388193
Sleep apnoea syndrome 23.55 10.18 23 200010 40424 110348842
COVID-19 23.54 10.18 307 199726 244753 110144513
Decreased appetite 23.50 10.18 1069 198964 474777 109914489
Chronic sinusitis 23.49 10.18 8 200025 25076 110364190
Tremor 23.44 10.18 243 199790 201989 110187277
Mouth swelling 23.15 10.18 45 199988 7309 110381957
Heart rate irregular 23.00 10.18 17 200016 34257 110355009
Abnormal behaviour 22.96 10.18 22 200011 39017 110350249
Cytomegalovirus infection reactivation 22.96 10.18 3 200030 18330 110370936
Trichomegaly 22.85 10.18 9 200024 140 110389126
Influenza 22.67 10.18 196 199837 168905 110220361
Insomnia 22.61 10.18 831 199202 359759 110029507
Blood pressure diastolic decreased 22.57 10.18 19 200014 35866 110353400
Respiratory disorder 22.26 10.18 212 199821 71170 110318096
Dementia 22.19 10.18 15 200018 31658 110357608
Balance disorder 22.11 10.18 122 199911 116438 110272828
Weight decreased 22.11 10.18 661 199372 467396 109921870
Status epilepticus 22.06 10.18 15 200018 31556 110357710
Asthenia 22.04 10.18 1020 199013 687979 109701287
Cataract 21.99 10.18 72 199961 79413 110309853
Feeling abnormal 21.83 10.18 215 199818 180496 110208770
Injection site pruritus 21.73 10.18 37 199996 51221 110338045
Progressive multifocal leukoencephalopathy 21.63 10.18 9 200024 24947 110364319
Pancytopenia 21.48 10.18 259 199774 209354 110179912
Hepatic failure 21.36 10.18 59 199974 68680 110320586
B-lymphocyte abnormalities 21.35 10.18 9 200024 168 110389098
Iodine deficiency 21.27 10.18 4 200029 0 110389266
Vitamin B2 deficiency 21.27 10.18 4 200029 0 110389266
Fatty acid deficiency 21.27 10.18 4 200029 0 110389266
Primary coenzyme Q10 deficiency 21.27 10.18 4 200029 0 110389266
Contraindicated product administered 21.27 10.18 594 199439 247673 110141593
Acquired haemophilia 21.23 10.18 25 200008 2606 110386660
Unresponsive to stimuli 21.16 10.18 53 199980 63737 110325529
Dermatitis atopic 21.16 10.18 97 199936 25444 110363822
Eating disorder 21.11 10.18 15 200018 30843 110358423
Haematotoxicity 21.04 10.18 6 200027 21076 110368190
Acute generalised exanthematous pustulosis 20.79 10.18 86 199947 21578 110367688
Metastases to liver 20.75 10.18 20 200013 35366 110353900
Periarticular thenar erythema with onycholysis 20.74 10.18 7 200026 68 110389198
Bacterial infection 20.67 10.18 32 200001 46004 110343262
Hypereosinophilic syndrome 20.64 10.18 15 200018 839 110388427
Delirium 20.56 10.18 351 199682 134674 110254592
Breast cancer stage II 20.52 10.18 101 199932 27274 110361992
Orthostatic hypotension 20.49 10.18 57 199976 66192 110323074
Drug-induced liver injury 20.47 10.18 318 199715 119749 110269517
Body temperature decreased 20.38 10.18 22 200011 36913 110352353
Hypokinesia 20.37 10.18 7 200026 21819 110367447
Device capturing issue 20.29 10.18 6 200027 36 110389230
Finger deformity 20.23 10.18 18 200015 33074 110356192
Rosacea 20.22 10.18 35 199998 5201 110384065
Ureaplasma infection 20.20 10.18 19 200014 1527 110387739
Pericardial effusion 20.20 10.18 46 199987 57171 110332095
Skin hyperpigmentation 20.18 10.18 47 199986 8649 110380617
Ear pain 20.18 10.18 165 199868 53061 110336205
Thrombotic microangiopathy 20.16 10.18 14 200019 29135 110360131
Factitious disorder 20.08 10.18 9 200024 196 110389070
Restlessness 20.05 10.18 45 199988 56214 110333052
Female genital tract fistula 19.99 10.18 3 200030 16516 110372750
Injection site bruising 19.96 10.18 39 199994 51224 110338042
Granuloma skin 19.94 10.18 55 199978 11228 110378038
Blood uric acid increased 19.93 10.18 7 200026 21522 110367744
Femur fracture 19.88 10.18 31 200002 44438 110344828
Fracture 19.84 10.18 10 200023 24778 110364488
Intentional product use issue 19.82 10.18 588 199445 247318 110141948
Tuberculosis 19.82 10.18 4 200029 17770 110371496
Weight fluctuation 19.77 10.18 86 199947 22059 110367207
Blood phosphorus increased 19.69 10.18 3 200030 16337 110372929
Ileus 19.66 10.18 16 200017 30713 110358553
Dermatitis bullous 19.59 10.18 73 199960 17456 110371810
Oesophageal irritation 19.53 10.18 10 200023 295 110388971
Transplant rejection 19.53 10.18 10 200023 24557 110364709
Motor dysfunction 19.30 10.18 10 200023 24396 110364870
Sudden death 19.28 10.18 10 200023 24385 110364881
Leukopenia 19.27 10.18 174 199859 148617 110240649
Appendicitis 19.26 10.18 14 200019 28450 110360816
Diabetes insipidus 19.23 10.18 39 199994 6531 110382735
Device leakage 19.22 10.18 3 200030 16045 110373221
Poisoning deliberate 19.09 10.18 12 200021 26319 110362947
Onychomycosis 19.07 10.18 25 200008 38506 110350760
Skin neoplasm excision 19.06 10.18 21 200012 2037 110387229
Crystal nephropathy 19.05 10.18 20 200013 1836 110387430
Malaria 18.99 10.18 11 200022 416 110388850
Coordination abnormal 18.99 10.18 11 200022 25217 110364049
Diffuse large B-cell lymphoma 18.98 10.18 3 200030 15895 110373371
Medical observation 18.97 10.18 9 200024 224 110389042
Metastases to lung 18.92 10.18 9 200024 23054 110366212
Myelodysplastic syndrome 18.88 10.18 24 200009 37460 110351806
Incorrect route of product administration 18.87 10.18 188 199845 63873 110325393
Intentional self-injury 18.82 10.18 24 200009 37405 110351861
Haematuria 18.55 10.18 82 199951 82923 110306343
Methaemoglobinaemia 18.55 10.18 47 199986 9121 110380145
IIIrd nerve injury 18.50 10.18 4 200029 4 110389262
Burn oesophageal 18.32 10.18 11 200022 445 110388821
Pneumonia 18.29 10.18 1352 198681 875362 109513904
Bronchial hyperreactivity 18.24 10.18 27 200006 3517 110385749
Ascites 18.23 10.18 96 199937 92712 110296554
Cinchonism 18.19 10.18 5 200028 22 110389244
Cardiac murmur 18.17 10.18 11 200022 24617 110364649
Eye injury 18.09 10.18 42 199991 7713 110381553
VIth nerve paralysis 18.06 10.18 19 200014 1748 110387518
Laboratory test abnormal 18.00 10.18 139 199894 43940 110345326
Psychotic disorder 17.94 10.18 41 199992 50896 110338370
Allergic sinusitis 17.94 10.18 19 200014 1762 110387504
Drug dependence 17.83 10.18 40 199993 49980 110339286
Cytomegalovirus viraemia 17.83 10.18 5 200028 17759 110371507
Superinfection 17.82 10.18 35 199998 5728 110383538
Respiratory failure 17.78 10.18 278 199755 215054 110174212
Dyskinesia 17.65 10.18 42 199991 51404 110337862
Graft versus host disease 17.61 10.18 6 200027 18800 110370466
Nasal congestion 17.50 10.18 105 199928 98177 110291089
Hepatic steatosis 17.45 10.18 39 199994 48792 110340474
Ulcer haemorrhage 17.44 10.18 84 199949 22487 110366779
Rash pustular 17.43 10.18 57 199976 12772 110376494
Aphasia 17.34 10.18 52 199981 58945 110330321
Pancreatic carcinoma 17.32 10.18 3 200030 14869 110374397
Incorrect dose administered 17.28 10.18 113 199920 103528 110285738
Eosinophilic pneumonia acute 17.19 10.18 18 200015 1647 110387619
Subarachnoid haemorrhage 17.17 10.18 17 200016 29685 110359581
Acne conglobata 17.05 10.18 5 200028 29 110389237
Hemiplegia 17.05 10.18 10 200023 22772 110366494
Gastritis erosive 16.93 10.18 54 199979 11946 110377320
Cough 16.91 10.18 673 199360 460968 109928298
Achromobacter infection 16.88 10.18 9 200024 289 110388977
Onychalgia 16.86 10.18 15 200018 1122 110388144
Odynophagia 16.84 10.18 60 199973 14041 110375225
Flatulence 16.78 10.18 44 199989 52105 110337161
Stress cardiomyopathy 16.72 10.18 4 200029 15802 110373464
Radiculopathy 16.72 10.18 7 200026 19329 110369937
Inappropriate antidiuretic hormone secretion 16.71 10.18 22 200011 33829 110355437
Lung neoplasm malignant 16.70 10.18 22 200011 33820 110355446
Nematodiasis 16.64 10.18 5 200028 32 110389234
Neutrophil count increased 16.62 10.18 23 200010 34629 110354637
Impaired work ability 16.60 10.18 14 200019 26405 110362861
Ataxia 16.54 10.18 18 200015 30090 110359176
Cardiotoxicity 16.49 10.18 5 200028 16876 110372390
Masked fever 16.38 10.18 5 200028 34 110389232
Sinus tachycardia 16.34 10.18 35 199998 44458 110344808
Pyelonephritis 16.34 10.18 13 200020 25237 110364029
Product quality issue 16.30 10.18 78 199955 77221 110312045
Granuloma annulare 16.22 10.18 13 200020 842 110388424
Fluid retention 16.14 10.18 102 199931 94205 110295061
Diabetes mellitus inadequate control 16.13 10.18 18 200015 29757 110359509
Keratitis fungal 16.13 10.18 10 200023 429 110388837
Mitral valve incompetence 16.11 10.18 22 200011 33307 110355959
Colorectal cancer metastatic 16.09 10.18 17 200016 1572 110387694
Product dose omission issue 16.05 10.18 451 199582 321331 110067935
Dyspepsia 15.82 10.18 455 199578 190510 110198756
Tricuspid valve incompetence 15.82 10.18 12 200021 23861 110365405
Device occlusion 15.76 10.18 4 200029 15181 110374085
Schizophrenia 15.75 10.18 10 200023 21816 110367450
Hyperphosphataemia 15.74 10.18 5 200028 16376 110372890
Injection site swelling 15.73 10.18 58 199975 61732 110327534
Blood potassium decreased 15.69 10.18 48 199985 54066 110335200
Mycobacterial peritonitis 15.65 10.18 8 200025 235 110389031
Drug withdrawal syndrome 15.65 10.18 28 200005 38026 110351240
Intestinal obstruction 15.58 10.18 47 199986 53180 110336086
Neoplasm malignant 15.58 10.18 27 200006 37116 110352150
Device malfunction 15.51 10.18 14 200019 25544 110363722
Eosinophilic myocarditis 15.50 10.18 19 200014 2066 110387200
Hypertension 15.43 10.18 1096 198937 508988 109880278
Vitamin K deficiency 15.38 10.18 13 200020 908 110388358
Vertigo 15.36 10.18 93 199940 86777 110302489
Device expulsion 15.33 10.18 20 200013 30871 110358395
Melaena 15.32 10.18 68 199965 68689 110320577
Erosive oesophagitis 15.25 10.18 23 200010 3046 110386220
Pulmonary arterial hypertension 15.24 10.18 22 200011 32546 110356720
Hepatotoxicity 15.18 10.18 61 199972 63339 110325927
Ejection fraction decreased 15.15 10.18 32 200001 40848 110348418
Flushing 15.13 10.18 119 199914 104617 110284649
Death neonatal 15.12 10.18 17 200016 1686 110387580
Disability 15.06 10.18 100 199933 30123 110359143
Periostosis 15.06 10.18 4 200029 15 110389251
Histoplasmosis disseminated 14.98 10.18 26 200007 3873 110385393
Internal injury 14.95 10.18 9 200024 366 110388900
Withdrawal syndrome 14.88 10.18 21 200012 31359 110357907
Adverse reaction 14.85 10.18 19 200014 29575 110359691
Proctitis 14.84 10.18 6 200027 16921 110372345
Muscle rigidity 14.78 10.18 13 200020 24018 110365248
Melanocytic naevus 14.73 10.18 32 200001 5622 110383644
Medical device discomfort 14.67 10.18 18 200015 1958 110387308
Enterocolitis 14.64 10.18 8 200025 18941 110370325
Arthritis 14.64 10.18 402 199631 167184 110222082
Osteonecrosis 14.63 10.18 24 200009 33717 110355549
Blood pressure systolic abnormal 14.62 10.18 14 200019 24836 110364430
Intestinal perforation 14.57 10.18 10 200023 20934 110368332
Brain oedema 14.56 10.18 21 200012 31077 110358189
Penile erythema 14.55 10.18 7 200026 180 110389086
Tachycardia 14.49 10.18 306 199727 226339 110162927
Influenza like illness 14.43 10.18 97 199936 88315 110300951
Mania 14.37 10.18 10 200023 20786 110368480
Hydronephrosis 14.20 10.18 10 200023 20655 110368611
Platelet count increased 14.18 10.18 16 200017 26318 110362948
Peripheral swelling 14.16 10.18 879 199154 403155 109986111
Dialysis 14.14 10.18 9 200024 19610 110369656
Exposure to toxic agent 14.11 10.18 3 200030 12855 110376411
Urosepsis 14.08 10.18 21 200012 30654 110358612
Personality disorder 14.08 10.18 3 200030 12834 110376432
Neuralgia 14.05 10.18 43 199990 48435 110340831
Accidental exposure to product 14.04 10.18 45 199988 49963 110339303
Palpitations 14.01 10.18 203 199830 159009 110230257
Sensory loss 13.94 10.18 11 200022 21446 110367820
Corynebacterium bacteraemia 13.91 10.18 7 200026 199 110389067
Atrial flutter 13.89 10.18 14 200019 24248 110365018
Therapy interrupted 13.87 10.18 45 199988 49777 110339489
Gastroenteritis 13.86 10.18 31 200002 38769 110350497
Pulmonary function test abnormal 13.84 10.18 29 200004 4971 110384295
Feeding disorder 13.82 10.18 11 200022 21351 110367915
Dermatitis 13.81 10.18 92 199941 27745 110361521
Blood glucose decreased 13.72 10.18 20 200013 29468 110359798
Loss of personal independence in daily activities 13.71 10.18 362 199671 149658 110239608
Hyperthermia 13.71 10.18 11 200022 21261 110368005
Infective pulmonary exacerbation of cystic fibrosis 13.68 10.18 58 199975 14713 110374553
Arrhythmia 13.65 10.18 72 199961 69503 110319763
Mydriasis 13.61 10.18 12 200021 22145 110367121
Plasma cell myeloma 13.57 10.18 63 199970 62873 110326393
Foetal death 13.57 10.18 6 200027 16039 110373227
Inflammatory marker increased 13.54 10.18 57 199976 14412 110374854
Dyslipidaemia 13.45 10.18 6 200027 15959 110373307
Atrioventricular block complete 13.43 10.18 10 200023 20072 110369194
Tendon pain 13.40 10.18 33 200000 6293 110382973
Head injury 13.31 10.18 37 199996 42980 110346286
Product prescribing issue 13.29 10.18 52 199981 12720 110376546
Neoplasm skin 13.14 10.18 22 200011 3182 110386084
Poor venous access 13.10 10.18 15 200018 24507 110364759
Blood pressure systolic decreased 13.09 10.18 4 200029 13437 110375829
Dysphonia 13.06 10.18 82 199951 75847 110313419
Periorbital swelling 13.05 10.18 30 200003 5475 110383791
Epistaxis 13.01 10.18 162 199871 130210 110259056
Hyperuricaemia 12.99 10.18 5 200028 14526 110374740
Device related infection 12.98 10.18 33 200000 39486 110349780
Drug dose omission by device 12.97 10.18 5 200028 14511 110374755
Epstein-Barr virus infection 12.96 10.18 9 200024 18729 110370537
Myoclonus 12.93 10.18 25 200008 32973 110356293
Dysstasia 12.92 10.18 25 200008 32961 110356305
Lung consolidation 12.87 10.18 45 199988 10431 110378835
SLE arthritis 12.76 10.18 10 200023 627 110388639
Noninfective oophoritis 12.74 10.18 5 200028 77 110389189
Neuropathy peripheral 12.68 10.18 238 199795 179039 110210227
Skin exfoliation 12.67 10.18 226 199807 87425 110301841
Post treatment Lyme disease syndrome 12.67 10.18 3 200030 6 110389260
Medical device site hyperaesthesia 12.67 10.18 3 200030 6 110389260
Lipoedema 12.66 10.18 7 200026 242 110389024
Agranulocytosis 12.63 10.18 63 199970 61697 110327569
Febrile bone marrow aplasia 12.61 10.18 8 200025 17457 110371809
Blood parathyroid hormone decreased 12.59 10.18 52 199981 13037 110376229
Transplant failure 12.58 10.18 30 200003 5605 110383661
Hiatus hernia 12.58 10.18 19 200014 27587 110361679
Salivary hypersecretion 12.55 10.18 8 200025 17413 110371853
Blood pressure diastolic abnormal 12.52 10.18 17 200016 25798 110363468
Arterial occlusive disease 12.52 10.18 6 200027 15302 110373964
Blood calcium decreased 12.51 10.18 29 200004 35816 110353450
Renal cancer 12.48 10.18 4 200029 13030 110376236
Pulmonary pain 12.46 10.18 32 200001 6261 110383005
Product substitution issue 12.43 10.18 14 200019 23047 110366219
Thrombosis 12.41 10.18 131 199902 108531 110280735
Presyncope 12.37 10.18 46 199987 48841 110340425
Cardiac disorder 12.30 10.18 84 199949 76196 110313070
Distal intestinal obstruction syndrome 12.27 10.18 12 200021 1013 110388253
Bundle branch block left 12.26 10.18 4 200029 12884 110376382
Bronchopulmonary aspergillosis 12.26 10.18 22 200011 29841 110359425
Intestinal ischaemia 12.25 10.18 7 200026 16172 110373094
Escherichia urinary tract infection 12.23 10.18 7 200026 16155 110373111
Oesophageal pain 12.22 10.18 28 200005 5097 110384169
Radiation fibrosis - lung 12.18 10.18 5 200028 87 110389179
Chest injury 12.15 10.18 22 200011 3387 110385879
Second primary malignancy 12.08 10.18 9 200024 18059 110371207
Respiratory acidosis 11.96 10.18 5 200028 13821 110375445
Musculoskeletal disorder 11.96 10.18 14 200019 22650 110366616
Panic disorder 11.91 10.18 22 200011 3439 110385827
Throat irritation 11.91 10.18 53 199980 53499 110335767
Diverticulitis 11.89 10.18 53 199980 53469 110335797
Painful respiration 11.88 10.18 23 200010 3724 110385542
Atrioventricular block 11.82 10.18 8 200025 16869 110372397
Rhinitis 11.81 10.18 14 200019 22531 110366735
Acidosis 11.80 10.18 14 200019 22517 110366749
Disseminated intravascular coagulation 11.70 10.18 37 199996 41249 110348017
Mental status changes 11.70 10.18 85 199948 76037 110313229
Cardiac tamponade 11.69 10.18 3 200030 11304 110377962
Myasthenia gravis 11.66 10.18 13 200020 21498 110367768
Hypotonia 11.66 10.18 7 200026 15738 110373528
Gout 11.65 10.18 31 200002 36535 110352731
Skin odour abnormal 11.64 10.18 18 200015 2436 110386830
Eosinophilic pneumonia chronic 11.57 10.18 9 200024 558 110388708
Obsessive rumination 11.57 10.18 3 200030 10 110389256
Naevoid melanoma 11.57 10.18 3 200030 10 110389256
Respiratory tract congestion 11.56 10.18 24 200009 30833 110358433
Affect lability 11.56 10.18 10 200023 18627 110370639
Infusion related reaction 11.52 10.18 819 199214 380343 110008923
Hepatitis chronic active 11.51 10.18 7 200026 290 110388976
Drug eruption 11.51 10.18 148 199885 53511 110335755
PaO2/FiO2 ratio decreased 11.49 10.18 4 200029 43 110389223
Oral mucosal blistering 11.46 10.18 36 199997 7898 110381368
Ventricular tachycardia 11.42 10.18 49 199984 49960 110339306
Rash morbilliform 11.42 10.18 36 199997 7915 110381351
Multiple sclerosis 11.41 10.18 18 200015 25680 110363586
Bone pain 11.38 10.18 70 199963 65063 110324203
Blood triglycerides increased 11.36 10.18 16 200017 23910 110365356
Coeliac disease 11.35 10.18 40 199993 43147 110346119
Panniculitis 11.33 10.18 57 199976 15525 110373741
Psychomotor hyperactivity 11.27 10.18 12 200021 20265 110369001
Colour blindness 11.26 10.18 9 200024 581 110388685
Colon cancer 11.24 10.18 8 200025 16435 110372831
Gastric cancer 11.23 10.18 3 200030 11005 110378261
Gastroduodenal haemorrhage 11.23 10.18 7 200026 303 110388963
SAPHO syndrome 11.19 10.18 9 200024 586 110388680
Bronchiectasis 11.19 10.18 108 199925 36385 110352881
Neurotoxicity 11.15 10.18 39 199994 42168 110347098
Tendon discomfort 11.11 10.18 9 200024 592 110388674
Pulmonary embolism 11.10 10.18 299 199734 214175 110175091
Hypoxia 11.10 10.18 166 199867 129349 110259917
Metastases to central nervous system 11.09 10.18 15 200018 22802 110366464
Granulomatous liver disease 11.08 10.18 14 200019 1570 110387696
Keratitis 11.07 10.18 27 200006 5117 110384149
Decubitus ulcer 11.05 10.18 10 200023 18226 110371040
Post inflammatory pigmentation change 11.03 10.18 10 200023 767 110388499
Suspected suicide 10.92 10.18 7 200026 15192 110374074
Pulmonary hypertension 10.91 10.18 57 199976 55163 110334103
Ventricular extrasystoles 10.89 10.18 15 200018 22626 110366640
Seronegative arthritis 10.88 10.18 50 199983 13127 110376139
Pulmonary mass 10.87 10.18 33 200000 37268 110351998
Chronic kidney disease 10.87 10.18 87 199946 76204 110313062
Dysgeusia 10.82 10.18 78 199955 69907 110319359
Acute graft versus host disease in skin 10.82 10.18 3 200030 10737 110378529
Corneal neovascularisation 10.81 10.18 6 200027 209 110389057
Blood calcium increased 10.81 10.18 10 200023 18030 110371236
Nervous system disorder 10.80 10.18 26 200007 31695 110357571
Nodular vasculitis 10.78 10.18 5 200028 118 110389148
Cachexia 10.78 10.18 5 200028 13000 110376266
Arteriosclerosis coronary artery 10.77 10.18 18 200015 25100 110364166
Generalised bullous fixed drug eruption 10.74 10.18 10 200023 794 110388472
Medical device pain 10.72 10.18 13 200020 1397 110387869
Angina bullosa haemorrhagica 10.70 10.18 6 200027 213 110389053
Metastases to lymph nodes 10.69 10.18 7 200026 15025 110374241
Lymphopenia 10.69 10.18 37 199996 40133 110349133
Apparent death 10.69 10.18 19 200014 2883 110386383
Rhinitis allergic 10.66 10.18 10 200023 17912 110371354
Toxic skin eruption 10.65 10.18 21 200012 27494 110361772
Vaginal discharge 10.64 10.18 10 200023 17898 110371368
Eosinophilic pneumonia 10.63 10.18 33 200000 7194 110382072
Nephrolithiasis 10.63 10.18 73 199960 66139 110323127
Electrolyte imbalance 10.62 10.18 33 200000 36995 110352271
Laryngeal injury 10.60 10.18 3 200030 15 110389251
Blood pressure diastolic increased 10.60 10.18 11 200022 18796 110370470
Symmetrical drug-related intertriginous and flexural exanthema 10.56 10.18 15 200018 1882 110387384
Rocky mountain spotted fever 10.54 10.18 4 200029 56 110389210
Temperature regulation disorder 10.53 10.18 5 200028 12821 110376445
Faecaloma 10.53 10.18 7 200026 14901 110374365
Secondary amyloidosis 10.51 10.18 7 200026 340 110388926
Amino acid level decreased 10.47 10.18 4 200029 57 110389209
Arthritis allergic 10.44 10.18 3 200030 16 110389250
Dermatomyositis 10.43 10.18 24 200009 4382 110384884
Aspiration 10.42 10.18 25 200008 30508 110358758
Osteonecrosis of jaw 10.39 10.18 48 199985 47969 110341297
Ischaemic cardiomyopathy 10.36 10.18 35 199998 7976 110381290
Mycobacterium fortuitum infection 10.34 10.18 8 200025 492 110388774
Hernia 10.34 10.18 12 200021 19488 110369778
Speech disorder 10.33 10.18 67 199966 61502 110327764
Infertility female 10.32 10.18 8 200025 494 110388772
Benign familial pemphigus 10.29 10.18 3 200030 17 110389249
Bacterial vulvovaginitis 10.28 10.18 9 200024 659 110388607
Lower gastrointestinal haemorrhage 10.21 10.18 11 200022 18475 110370791
Rash macular 10.19 10.18 111 199922 38575 110350691
Epilepsy 10.19 10.18 124 199909 100085 110289181

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AB22 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Antiinfectives and antiseptics for local oral treatment
ATC J01AA02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
TETRACYCLINES
Tetracyclines
FDA Chemical/Ingredient N0000007948 Tetracyclines
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
FDA EPC N0000175882 Tetracycline-class Drug
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:50846 immunomodulator
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:176497 geroprotector
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35441 antiinfective agent

Related Drugs by ATC class:

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J01AA Tetracyclines 13 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Trachoma indication 2576002 DOID:11265
Listeriosis indication 4241002 DOID:11573
Inhalational anthrax indication 11389007
Actinomycotic infection indication 11817007 DOID:8478
Gonorrhea indication 15628003 DOID:7551
Tularemia indication 19265001
Infection of skin AND/OR subcutaneous tissue indication 19824006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Murine typhus indication 25668000 DOID:11256
Granuloma inguinale indication 28867007 DOID:9113
Acute gonococcal urethritis indication 29864006
Acute gonococcal epididymo-orchitis indication 30168008 DOID:10802
Bronchitis indication 32398004 DOID:6132
Sinusitis indication 36971009
Disease caused by rickettsiae indication 37246009
Louse-borne typhus indication 39111003 DOID:11256
Gonorrhea of rectum indication 42746002
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Brill-Zinsser disease indication 47761007 DOID:11254
Bacterial pneumonia indication 53084003 DOID:874
Cholera indication 63650001 DOID:1498
Acute gonococcal endometritis indication 65295003 DOID:7527
Yaws indication 70647001 DOID:10371
Gonorrhea of pharynx indication 74372003
Rickettsialpox indication 75096007 DOID:11103
Ornithosis indication 75116005 DOID:11262
Acute bacterial sinusitis indication 75498004
Brucellosis indication 75702008 DOID:11077
Syphilis indication 76272004
Nongonococcal urethritis indication 84619001
Cutaneous anthrax indication 84980006 DOID:7426
Acne vulgaris indication 88616000
Q fever endocarditis indication 95890006
Chlamydial infection indication 105629000
Gastrointestinal anthrax indication 111798006 DOID:13386
Rocky Mountain spotted fever indication 186772009
Boutonneuse fever indication 186774005 DOID:14095
Q fever indication 186788009 DOID:11100
Lymphogranuloma venereum indication 186946009 DOID:13819
Inclusion conjunctivitis indication 266109000
Bartonellosis indication 266123003 DOID:11102
Chancroid indication 266143009 DOID:13778
Scrub typhus indication 271425001 DOID:13371
Bacterial urinary infection indication 312124009
Pharyngitis indication 405737000 DOID:2275
Anthrax indication 409498004 DOID:7427
Relapsing fever indication 420079008 DOID:13034
Chlamydia trachomatis infection of genital structure indication 428015005
Periodontitis Adjunct Therapy indication
Chloroquine-Resistant Plasmodium Falciparum Malaria Prevention indication
Typhus Infections indication
Disseminated Gonococcal Infection indication
Severe Recalcitrant Nodular Rosacea indication
Rectal Chlamydia Trachomatis Infection indication
Traveler's diarrhea off-label use 11840006
Gingivostomatitis off-label use 20607006
Lyme disease off-label use 23502006 DOID:11729
Vivax malaria off-label use 27052006 DOID:12978
Lyme arthritis off-label use 33937009
Enterocolitis off-label use 43752006
Plague off-label use 58750007 DOID:3482
Malaria off-label use 61462000 DOID:12365
Ehrlichiosis off-label use 77361002
Leptospirosis off-label use 77377001 DOID:2297
Lyme carditis off-label use 77863005
Atypical mycobacterial infection off-label use 111812000
Ocular rosacea off-label use 200933006
Chlamydial epididymitis off-label use 236767000
Rosacea off-label use 398909004 DOID:8881
Sexual Transmitted Disease Exposure from Sexual Assault off-label use
Postexposure Plague Prophylaxis off-label use
Lyme Disease Prevention off-label use
Pleural Malignant Effusions off-label use
Chloroquine Resistant Plasmodium Falciparum Malaria off-label use
Esophageal dysmotility contraindication 266434009 DOID:9192
Pregnancy, function contraindication 289908002
Pseudomembranous enterocolitis contraindication 397683000




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Periodontal disease Indication

🐶 Veterinary products

ProductApplicantIngredients
Doxirobe Gel Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.23 acidic
pKa2 7.13 acidic
pKa3 9.78 acidic
pKa4 11.26 acidic
pKa5 12.46 acidic
pKa6 13.08 acidic
pKa7 9.07 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
40MG ORACEA GALDERMA LABS LP N050805 May 26, 2006 RX CAPSULE ORAL 7749532 Dec. 19, 2027 TREATMENT OF ONLY INFLAMMATORY LESIONS (PAPULES AND PUSTULES) OF ROSACEA
EQ 120MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** DORYX MPC MAYNE PHARMA N050795 May 20, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9295652 Oct. 23, 2034 TO TREAT OR PREVENT INFECTIONS CAUSED BY SUSCEPTIBLE BACTERIA USING DELAYED-RELEASE TABLETS CONSISTING OF DOXYCYCLINE HYCLATE COATED PELLETS IN A TABLET
EQ 60MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** DORYX MPC MAYNE PHARMA N050795 May 20, 2016 RX TABLET, DELAYED RELEASE ORAL 9295652 Oct. 23, 2034 TO TREAT OR PREVENT INFECTIONS CAUSED BY SUSCEPTIBLE BACTERIA USING DELAYED-RELEASE TABLETS CONSISTING OF DOXYCYCLINE HYCLATE COATED PELLETS IN A TABLET
EQ 120MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** DORYX MPC MAYNE PHARMA N050795 May 20, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9446057 Dec. 23, 2034 TO TREAT OR PREVENT INFECTIONS CAUSED BY SUSCEPTIBLE BACTERIA USING DELAYED-RELEASE TABLETS CONSISTING OF DOXYCYCLINE HYCLATE COATED PELLETS IN A TABLET
EQ 60MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** DORYX MPC MAYNE PHARMA N050795 May 20, 2016 RX TABLET, DELAYED RELEASE ORAL 9446057 Dec. 23, 2034 TO TREAT OR PREVENT INFECTIONS CAUSED BY SUSCEPTIBLE BACTERIA USING DELAYED-RELEASE TABLETS CONSISTING OF DOXYCYCLINE HYCLATE COATED PELLETS IN A TABLET

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
72 kDa type IV collagenase Enzyme IC50 4.62 CHEMBL
Stromelysin-1 Enzyme IC50 4.60 CHEMBL
Neutrophil collagenase Enzyme INHIBITOR IC50 4.60 IUPHAR
Collagenase 3 Enzyme INHIBITOR IC50 4.40 CHEMBL
Matrilysin Enzyme INHIBITOR Kd 4.14 IUPHAR
50S ribosomal protein L10 Ribosomal protein WOMBAT-PK
Tetracycline resistance protein, class B Transporter IC50 5.04 WOMBAT-PK
Zinc finger protein mex-5 Cytosolic other EC50 4.42 WOMBAT-PK

External reference:

IDSource
4017742 VUID
N0000146109 NUI
D00307 KEGG_DRUG
17086-28-1 SECONDARY_CAS_RN
24390-14-5 SECONDARY_CAS_RN
94088-85-4 SECONDARY_CAS_RN
4017738 VANDF
4017740 VANDF
4017742 VANDF
C0013090 UMLSCUI
CHEBI:50845 CHEBI
DXT PDB_CHEM_ID
CHEMBL1200699 ChEMBL_ID
CHEMBL3989740 ChEMBL_ID
CHEMBL2364574 ChEMBL_ID
CHEMBL1256723 ChEMBL_ID
D004318 MESH_DESCRIPTOR_UI
DB00254 DRUGBANK_ID
6464 IUPHAR_LIGAND_ID
10592-13-9 SECONDARY_CAS_RN
N12000U13O UNII
54671203 PUBCHEM_CID
1543946 RXNORM
21502 MMSL
227071 MMSL
230639 MMSL
30716 MMSL
3375 MMSL
4641 MMSL
4642 MMSL
d00037 MMSL
002748 NDDF
002749 NDDF
002750 NDDF
006525 NDDF
10504007 SNOMEDCT_US
372478003 SNOMEDCT_US
63559007 SNOMEDCT_US
71417000 SNOMEDCT_US
734475000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0115-1327 CAPSULE 150 mg ORAL ANDA 28 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0143-2112 TABLET, COATED 100 mg ORAL ANDA 25 sections
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9381 INJECTION, POWDER, FOR SOLUTION 100 mg INTRAVENOUS ANDA 15 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9802 CAPSULE 50 mg ORAL ANDA 26 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9802 CAPSULE 50 mg ORAL ANDA 26 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9803 CAPSULE 100 mg ORAL ANDA 26 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9803 CAPSULE 100 mg ORAL ANDA 26 sections
ORACEA HUMAN PRESCRIPTION DRUG LABEL 1 0299-3822 CAPSULE 40 mg ORAL NDA 25 sections
doxycycline hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0167 TABLET, FILM COATED 100 mg ORAL ANDA 28 sections
DOXYCYCLINE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9855 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 11 sections
DOXYCYCLINE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9855 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 11 sections
Doxycyclate Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0440-1481 CAPSULE 100 mg ORAL ANDA 25 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0440-7481 CAPSULE 100 mg ORAL ANDA 22 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0440-7482 TABLET 100 mg ORAL ANDA 24 sections
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0440-7483 TABLET, COATED 100 mg ORAL ANDA 25 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0463-2013 CAPSULE 100 mg ORAL ANDA 22 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0463-6000 TABLET 100 mg ORAL ANDA 16 sections
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0527-1335 TABLET, FILM COATED 50 mg ORAL ANDA 25 sections
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0527-1338 TABLET, FILM COATED 100 mg ORAL ANDA 25 sections
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0527-1535 TABLET, FILM COATED 75 mg ORAL ANDA 25 sections
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0527-1537 TABLET, FILM COATED 150 mg ORAL ANDA 25 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0591-4550 TABLET, DELAYED RELEASE 50 mg ORAL ANDA 28 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0591-4575 TABLET, DELAYED RELEASE 200 mg ORAL ANDA 28 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0591-5553 TABLET 100 mg ORAL ANDA 24 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8529 TABLET 100 mg ORAL ANDA 21 sections
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0713-0570 CAPSULE 50 mg ORAL ANDA 16 sections
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0713-0571 CAPSULE 75 mg ORAL ANDA 16 sections
Doxycycline HUMAN PRESCRIPTION DRUG LABEL 1 0713-0572 CAPSULE 100 mg ORAL ANDA 16 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0904-0428 CAPSULE 100 mg ORAL ANDA 25 sections
Doxycycline Hyclate HUMAN PRESCRIPTION DRUG LABEL 1 0904-0430 TABLET, COATED 100 mg ORAL ANDA 25 sections